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PMC:1359071 / 27692-33163 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
16462940-15467983-86014495 550-552 15467983 denotes 22
16462940-15457344-86014495 550-552 15457344 denotes 22
16462940-14993241-86014495 550-552 14993241 denotes 22
16462940-15722954-86014495 550-552 15722954 denotes 22
16462940-8770600-86014496 1367-1369 8770600 denotes 26
16462940-10353911-86014496 1367-1369 10353911 denotes 26
16462940-12855751-86014496 1367-1369 12855751 denotes 26
16462940-8770600-86014497 1378-1380 8770600 denotes 26
16462940-15044658-86014498 1381-1383 15044658 denotes 29
16462940-9725853-86014499 1394-1396 9725853 denotes 19
16462940-15044658-86014500 1397-1399 15044658 denotes 29
16462940-12646919-86014501 1553-1554 12646919 denotes 5
16462940-12646919-86014502 3013-3014 12646919 denotes 5
16462940-15711544-86014503 3015-3017 15711544 denotes 15
16462940-15837804-86014504 3814-3816 15837804 denotes 30
T88409 550-552 15467983 denotes 22
T81197 550-552 15457344 denotes 22
T66925 550-552 14993241 denotes 22
T32941 550-552 15722954 denotes 22
T36625 1367-1369 8770600 denotes 26
T12720 1367-1369 10353911 denotes 26
T28858 1367-1369 12855751 denotes 26
T75575 1378-1380 8770600 denotes 26
T39830 1381-1383 15044658 denotes 29
T91815 1394-1396 9725853 denotes 19
T84579 1397-1399 15044658 denotes 29
T38280 1553-1554 12646919 denotes 5
T99391 3013-3014 12646919 denotes 5
T24477 3015-3017 15711544 denotes 15
T78375 3814-3816 15837804 denotes 30

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T13600 28-41 _FRAGMENT denotes Regulation of
T13601 66-81 GO:0010468 denotes Gene Expression
T13602 66-70 SO:0000704 denotes Gene
T13603 160-167 GO:0065007 denotes control
T13604 255-259 SO:0000771 denotes QTLs
T13605 482-485 SO:0000771 denotes QTL
T13606 683-686 SO:0000771 denotes QTL
T13607 719-725 SO:0001026 denotes genome
T13608 828-832 SO:0000771 denotes QTLs
T13609 937-941 SO:0000771 denotes QTLs
T13610 1007-1014 UBERON:0000991 denotes gonadal
T13611 1239-1243 SO:0000771 denotes QTLs
T13612 1269-1276 UBERON:0000991 denotes gonadal
T13613 1286-1299 UBERON:0007808 denotes abdominal fat
T13614 1468-1471 SO:0000771 denotes QTL
T13615 1640-1649 SO:0001024 denotes haplotype
T13616 1748-1755 SO:0000704 denotes genetic
T13617 1756-1766 GO:0065007 denotes regulation
T13618 1842-1846 PR:000004155 denotes ApoE
T13619 1971-1976 NCBITaxon:9606 denotes human
T13620 2110-2117 UBERON:0000991 denotes gonadal
T13621 2144-2151 SO:0000704 denotes genetic
T13622 2152-2162 GO:0065007 denotes regulation
T13623 2208-2213 SO:0000704 denotes genes
T13624 2283-2289 SO:0001026 denotes genome
T13625 2295-2305 GO:0010467 denotes expression
T13626 2394-2400 UBERON:0000062 denotes organs
T13627 2450-2455 SO:0000704 denotes genes
T13628 2514-2524 SO:0000673 denotes transcript
T13629 2571-2578 SO:0000704 denotes genetic
T13630 2579-2589 GO:0065007 denotes regulation
T13631 2614-2618 SO:0000704 denotes gene
T13632 2614-2629 GO:0010467 denotes gene expression
T13633 2737-2742 SO:0000704 denotes genes
T13634 2777-2783 SO:0001026 denotes genome
T13635 2860-2865 SO:0000704 denotes genes
T13636 3304-3333 GO:0010468 denotes regulation of gene expression
T13637 3318-3322 SO:0000704 denotes gene
T13638 3373-3377 SO:0000704 denotes gene
T13639 3405-3412 SO:0000704 denotes genetic
T13640 3413-3423 GO:0065007 denotes regulation
T13641 3432-3443 SO:0000673 denotes transcripts
T13642 3587-3594 SO:0000704 denotes genetic
T13643 3595-3624 GO:0010468 denotes regulation of gene expression
T13644 3609-3613 SO:0000704 denotes gene
T13645 3658-3669 CHEBI:50112 denotes sex hormone
T13646 3875-3880 NCBITaxon:10088 denotes mouse
T13647 3881-3887 SO:0001026 denotes genome
T13648 3948-3955 UBERON:0000991 denotes gonadal
T13649 4047-4054 UBERON:0000991 denotes gonadal
T13650 4415-4420 SO:0000704 denotes genes
T13651 4483-4488 SO:0000704 denotes genes
T13652 4516-4526 SO:0000673 denotes transcript
T13653 4527-4537 GO:0010467 denotes expression
T13654 4650-4655 SO:0000704 denotes genes
T13655 4751-4756 SO:0000704 denotes genes
T13656 4840-4844 SO:0000704 denotes gene
T13657 4861-4874 GO:0006412 denotes translational
T13658 4939-4948 GO:0065007 denotes regulated
T13659 5101-5106 UBERON:0000062 denotes organ
T13660 5116-5120 SO:0000704 denotes gene
T13661 5116-5131 GO:0010467 denotes gene expression
T13662 5199-5203 SO:0000704 denotes gene
T13663 5211-5217 UBERON:0000479 denotes tissue
T13664 5237-5243 UBERON:0000479 denotes tissue
T13665 5254-5261 GO:0065007 denotes control
T13666 5324-5338 UBERON:0001013 denotes adipose tissue
T13667 5354-5364 GO:0065007 denotes controlled
T13668 5377-5384 UBERON:0000479 denotes tissues
T13669 5425-5430 SO:0000704 denotes genes
R3815 T13601 T13600 _lexicallyChainedTo Gene Expression,Regulation of

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T13670 28-41 _FRAGMENT denotes Regulation of
T13671 66-81 GO:0010468 denotes Gene Expression
T13672 66-70 SO_EXT:0000704 denotes Gene
T13673 116-123 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T13674 128-133 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T13675 160-167 GO:0065007 denotes control
T13676 255-259 SO_EXT:0000771 denotes QTLs
T13677 482-485 SO_EXT:0000771 denotes QTL
T13678 683-686 SO_EXT:0000771 denotes QTL
T13679 719-725 SO_EXT:0001026 denotes genome
T13680 734-744 GO_SO_EXT:chromosome denotes Chromosome
T13681 828-832 SO_EXT:0000771 denotes QTLs
T13682 885-892 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T13683 897-902 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T13684 937-941 SO_EXT:0000771 denotes QTLs
T13685 1007-1014 UBERON:0000991 denotes gonadal
T13686 1015-1018 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13687 1033-1044 GO_SO_EXT:chromosome denotes Chromosomes
T13688 1135-1142 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T13689 1239-1243 SO_EXT:0000771 denotes QTLs
T13690 1269-1276 UBERON:0000991 denotes gonadal
T13691 1277-1280 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13692 1286-1299 UBERON:0007808 denotes abdominal fat
T13693 1296-1299 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13694 1352-1363 GO_SO_EXT:chromosome denotes Chromosomes
T13695 1436-1446 GO_SO_EXT:chromosome denotes Chromosome
T13696 1468-1471 SO_EXT:0000771 denotes QTL
T13697 1492-1502 GO_SO_EXT:chromosome denotes Chromosome
T13698 1515-1518 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13699 1640-1649 SO_EXT:0001024 denotes haplotype
T13700 1748-1755 SO_EXT:0000704 denotes genetic
T13701 1756-1766 GO:0065007 denotes regulation
T13702 1829-1841 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T13703 1842-1846 PR_EXT:000004155 denotes ApoE
T13704 1846-1847 SO_EXT:sequence_nullness_or_absence denotes −
T13705 1848-1849 SO_EXT:sequence_nullness_or_absence denotes −
T13706 1874-1877 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13707 1971-1976 NCBITaxon:9606 denotes human
T13708 2016-2022 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T13709 2110-2117 UBERON:0000991 denotes gonadal
T13710 2118-2125 CHEBI_GO_EXT:hormone denotes hormone
T13711 2126-2136 GO_EXT:secretion_entity_or_process denotes secretions
T13712 2144-2151 SO_EXT:0000704 denotes genetic
T13713 2152-2162 GO:0065007 denotes regulation
T13714 2208-2213 SO_EXT:0000704 denotes genes
T13715 2283-2289 SO_EXT:0001026 denotes genome
T13716 2295-2305 GO:0010467 denotes expression
T13717 2368-2381 GO_EXT:transcription denotes transcription
T13718 2394-2400 UBERON:0000062 denotes organs
T13719 2450-2455 SO_EXT:0000704 denotes genes
T13720 2514-2524 SO_EXT:0000673 denotes transcript
T13721 2571-2578 SO_EXT:0000704 denotes genetic
T13722 2579-2589 GO:0065007 denotes regulation
T13723 2614-2618 SO_EXT:0000704 denotes gene
T13724 2614-2629 GO:0010467 denotes gene expression
T13725 2672-2682 SO_EXT:sequence_variation_entity_or_quality denotes variations
T13726 2699-2712 GO_EXT:transcription denotes transcription
T13727 2737-2742 SO_EXT:0000704 denotes genes
T13728 2777-2783 SO_EXT:0001026 denotes genome
T13729 2860-2865 SO_EXT:0000704 denotes genes
T13730 3080-3090 SO_EXT:sequence_variation_entity_or_quality denotes variations
T13731 3101-3114 GO_EXT:transcription denotes transcription
T13732 3304-3333 GO:0010468 denotes regulation of gene expression
T13733 3318-3322 SO_EXT:0000704 denotes gene
T13734 3348-3361 SO_EXT:polymorphism denotes polymorphisms
T13735 3373-3377 SO_EXT:0000704 denotes gene
T13736 3405-3412 SO_EXT:0000704 denotes genetic
T13737 3413-3423 GO:0065007 denotes regulation
T13738 3432-3443 SO_EXT:0000673 denotes transcripts
T13739 3525-3533 CHEBI_GO_EXT:hormone denotes hormones
T13740 3587-3594 SO_EXT:0000704 denotes genetic
T13741 3595-3624 GO:0010468 denotes regulation of gene expression
T13742 3609-3613 SO_EXT:0000704 denotes gene
T13743 3658-3669 CHEBI_EXT:50112 denotes sex hormone
T13744 3662-3669 CHEBI_GO_EXT:hormone denotes hormone
T13745 3846-3857 SO_EXT:polymorphism denotes polymorphic
T13746 3875-3880 NCBITaxon:10088 denotes mouse
T13747 3881-3887 SO_EXT:0001026 denotes genome
T13748 3948-3955 UBERON:0000991 denotes gonadal
T13749 3956-3959 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13750 4047-4054 UBERON:0000991 denotes gonadal
T13751 4055-4058 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13752 4415-4420 SO_EXT:0000704 denotes genes
T13753 4483-4488 SO_EXT:0000704 denotes genes
T13754 4516-4526 SO_EXT:0000673 denotes transcript
T13755 4527-4537 GO:0010467 denotes expression
T13756 4579-4591 SO_EXT:polymorphism denotes polymorphism
T13757 4650-4655 SO_EXT:0000704 denotes genes
T13758 4751-4756 SO_EXT:0000704 denotes genes
T13759 4791-4804 SO_EXT:polymorphism denotes polymorphisms
T13760 4840-4844 SO_EXT:0000704 denotes gene
T13761 4857-4888 GO_SO_EXT:post_translational_modification_entity_or_process denotes posttranslational modifications
T13762 4939-4948 GO:0065007 denotes regulated
T13763 4983-4996 GO_EXT:transcription denotes transcription
T13764 5000-5004 CHEBI_SO_EXT:mRNA denotes mRNA
T13765 5101-5106 UBERON:0000062 denotes organ
T13766 5116-5120 SO_EXT:0000704 denotes gene
T13767 5116-5131 GO:0010467 denotes gene expression
T13768 5199-5203 SO_EXT:0000704 denotes gene
T13769 5211-5217 UBERON:0000479 denotes tissue
T13770 5237-5243 UBERON:0000479 denotes tissue
T13771 5254-5261 GO:0065007 denotes control
T13772 5324-5338 UBERON:0001013 denotes adipose tissue
T13773 5354-5364 GO:0065007 denotes controlled
T13774 5377-5384 UBERON:0000479 denotes tissues
T13775 5425-5430 SO_EXT:0000704 denotes genes
R3816 T13671 T13670 _lexicallyChainedTo Gene Expression,Regulation of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T13776 0-11 JJ denotes Significant
T13777 16-20 NN denotes Bias
T13778 12-15 NN denotes Sex
T13779 21-23 IN denotes in
T13780 24-27 DT denotes the
T13781 28-38 NN denotes Regulation
T13782 39-41 IN denotes of
T13783 42-46 CC denotes Both
T13784 55-61 NNS denotes Traits
T13785 47-54 JJ denotes Complex
T13786 62-65 CC denotes and
T13787 66-70 NN denotes Gene
T13788 71-81 NN denotes Expression
T13789 81-313 sentence denotes Given the known dichotomy between females and males in the susceptibility and control of obesity, this study was designed to sufficiently power the detection of significant QTLs for this and other traits with sex-dependent effects.
T13790 82-87 VBN denotes Given
T13791 195-203 VBN denotes designed
T13792 88-91 DT denotes the
T13793 98-107 NN denotes dichotomy
T13794 92-97 JJ denotes known
T13795 108-115 IN denotes between
T13796 116-123 NNS denotes females
T13797 124-127 CC denotes and
T13798 128-133 NNS denotes males
T13799 134-136 IN denotes in
T13800 137-140 DT denotes the
T13801 141-155 NN denotes susceptibility
T13802 156-159 CC denotes and
T13803 160-167 NN denotes control
T13804 168-170 IN denotes of
T13805 171-178 NN denotes obesity
T13806 178-180 , denotes ,
T13807 180-184 DT denotes this
T13808 185-190 NN denotes study
T13809 191-194 VBD denotes was
T13810 204-206 TO denotes to
T13811 220-225 VB denotes power
T13812 207-219 RB denotes sufficiently
T13813 226-229 DT denotes the
T13814 230-239 NN denotes detection
T13815 240-242 IN denotes of
T13816 243-254 JJ denotes significant
T13817 255-259 NNS denotes QTLs
T13818 260-263 IN denotes for
T13819 264-268 DT denotes this
T13820 269-272 CC denotes and
T13821 273-278 JJ denotes other
T13822 279-285 NNS denotes traits
T13823 286-290 IN denotes with
T13824 291-294 NN denotes sex
T13825 295-304 JJ denotes dependent
T13826 294-295 HYPH denotes -
T13827 305-312 NNS denotes effects
T13828 312-313 . denotes .
T13829 313-420 sentence denotes Note, however, that these effects can extend to traits without overall mean differences between the sexes.
T13830 314-318 VB denotes Note
T13831 318-320 , denotes ,
T13832 320-327 RB denotes however
T13833 327-329 , denotes ,
T13834 329-333 IN denotes that
T13835 352-358 VB denotes extend
T13836 334-339 DT denotes these
T13837 340-347 NNS denotes effects
T13838 348-351 MD denotes can
T13839 359-361 IN denotes to
T13840 362-368 NNS denotes traits
T13841 369-376 IN denotes without
T13842 377-384 JJ denotes overall
T13843 390-401 NNS denotes differences
T13844 385-389 NN denotes mean
T13845 402-409 IN denotes between
T13846 410-413 DT denotes the
T13847 414-419 NNS denotes sexes
T13848 419-420 . denotes .
T13849 420-557 sentence denotes Previous studies have described the advantages of performing QTL analysis both with and without sex as an interactive covariate [22–25].
T13850 421-429 JJ denotes Previous
T13851 430-437 NNS denotes studies
T13852 443-452 VBN denotes described
T13853 438-442 VBP denotes have
T13854 453-456 DT denotes the
T13855 457-467 NNS denotes advantages
T13856 468-470 IN denotes of
T13857 471-481 VBG denotes performing
T13858 482-485 NN denotes QTL
T13859 486-494 NN denotes analysis
T13860 495-499 CC denotes both
T13861 500-504 IN denotes with
T13862 505-508 CC denotes and
T13863 509-516 IN denotes without
T13864 517-520 NN denotes sex
T13865 521-523 IN denotes as
T13866 524-526 DT denotes an
T13867 539-548 NN denotes covariate
T13868 527-538 JJ denotes interactive
T13869 549-550 -LRB- denotes [
T13870 550-552 CD denotes 22
T13871 552-553 SYM denotes –
T13872 553-555 CD denotes 25
T13873 555-556 -RRB- denotes ]
T13874 556-557 . denotes .
T13875 557-759 sentence denotes Analyzing the sexes separately is suboptimal since it reduces sample size in both groups, thus reducing power to detect main QTL effects, as demonstrated by our genome scan of Chromosome 5 (Figure 1B).
T13876 558-567 VBG denotes Analyzing
T13877 589-591 VBZ denotes is
T13878 568-571 DT denotes the
T13879 572-577 NNS denotes sexes
T13880 578-588 RB denotes separately
T13881 592-602 JJ denotes suboptimal
T13882 603-608 IN denotes since
T13883 612-619 VBZ denotes reduces
T13884 609-611 PRP denotes it
T13885 620-626 NN denotes sample
T13886 627-631 NN denotes size
T13887 632-634 IN denotes in
T13888 635-639 DT denotes both
T13889 640-646 NNS denotes groups
T13890 646-648 , denotes ,
T13891 648-652 RB denotes thus
T13892 653-661 VBG denotes reducing
T13893 662-667 NN denotes power
T13894 668-670 TO denotes to
T13895 671-677 VB denotes detect
T13896 678-682 JJ denotes main
T13897 687-694 NNS denotes effects
T13898 683-686 NN denotes QTL
T13899 694-696 , denotes ,
T13900 696-698 IN denotes as
T13901 699-711 VBN denotes demonstrated
T13902 712-714 IN denotes by
T13903 715-718 PRP$ denotes our
T13904 726-730 NN denotes scan
T13905 719-725 NN denotes genome
T13906 731-733 IN denotes of
T13907 734-744 NN denotes Chromosome
T13908 745-746 CD denotes 5
T13909 747-748 -LRB- denotes (
T13910 755-757 NN denotes 1B
T13911 748-754 NN denotes Figure
T13912 757-758 -RRB- denotes )
T13913 758-759 . denotes .
T13914 759-962 sentence denotes Furthermore, separate analyses would not allow for the detection of QTLs that have opposing, or sex-antagonistic, effects in females and males and would hinder the detection of QTLs specific to one sex.
T13915 760-771 RB denotes Furthermore
T13916 801-806 VB denotes allow
T13917 771-773 , denotes ,
T13918 773-781 JJ denotes separate
T13919 782-790 NNS denotes analyses
T13920 791-796 MD denotes would
T13921 797-800 RB denotes not
T13922 807-810 IN denotes for
T13923 811-814 DT denotes the
T13924 815-824 NN denotes detection
T13925 825-827 IN denotes of
T13926 828-832 NNS denotes QTLs
T13927 833-837 WDT denotes that
T13928 838-842 VBP denotes have
T13929 843-851 VBG denotes opposing
T13930 874-881 NNS denotes effects
T13931 851-853 , denotes ,
T13932 853-855 CC denotes or
T13933 856-859 NN denotes sex
T13934 860-872 JJ denotes antagonistic
T13935 859-860 HYPH denotes -
T13936 872-874 , denotes ,
T13937 882-884 IN denotes in
T13938 885-892 NNS denotes females
T13939 893-896 CC denotes and
T13940 897-902 NNS denotes males
T13941 903-906 CC denotes and
T13942 907-912 MD denotes would
T13943 913-919 VB denotes hinder
T13944 920-923 DT denotes the
T13945 924-933 NN denotes detection
T13946 934-936 IN denotes of
T13947 937-941 NNS denotes QTLs
T13948 942-950 JJ denotes specific
T13949 951-953 IN denotes to
T13950 954-957 CD denotes one
T13951 958-961 NN denotes sex
T13952 961-962 . denotes .
T13953 962-1065 sentence denotes Accordingly, we detected five cQTLs for the gonadal fat mass trait on Chromosomes 1, 3, 5, 11, and 19.
T13954 963-974 RB denotes Accordingly
T13955 979-987 VBD denotes detected
T13956 974-976 , denotes ,
T13957 976-978 PRP denotes we
T13958 988-992 CD denotes five
T13959 993-998 NNS denotes cQTLs
T13960 999-1002 IN denotes for
T13961 1003-1006 DT denotes the
T13962 1024-1029 NN denotes trait
T13963 1007-1014 JJ denotes gonadal
T13964 1019-1023 NN denotes mass
T13965 1015-1018 NN denotes fat
T13966 1030-1032 IN denotes on
T13967 1033-1044 NNS denotes Chromosomes
T13968 1045-1046 CD denotes 1
T13969 1046-1048 , denotes ,
T13970 1048-1049 CD denotes 3
T13971 1049-1051 , denotes ,
T13972 1051-1052 CD denotes 5
T13973 1052-1054 , denotes ,
T13974 1054-1056 CD denotes 11
T13975 1056-1058 , denotes ,
T13976 1058-1061 CC denotes and
T13977 1062-1064 CD denotes 19
T13978 1064-1065 . denotes .
T13979 1065-1238 sentence denotes The detection of all five cQTLs was “driven” by the larger effect in females, with significant improvement by the incorporation of sex*additive and sex*dominant parameters.
T13980 1066-1069 DT denotes The
T13981 1070-1079 NN denotes detection
T13982 1103-1109 VBN denotes driven
T13983 1080-1082 IN denotes of
T13984 1083-1086 DT denotes all
T13985 1092-1097 NNS denotes cQTLs
T13986 1087-1091 CD denotes five
T13987 1098-1101 VBD denotes was
T13988 1102-1103 `` denotes “
T13989 1109-1110 '' denotes ”
T13990 1111-1113 IN denotes by
T13991 1114-1117 DT denotes the
T13992 1125-1131 NN denotes effect
T13993 1118-1124 JJR denotes larger
T13994 1132-1134 IN denotes in
T13995 1135-1142 NNS denotes females
T13996 1142-1144 , denotes ,
T13997 1144-1148 IN denotes with
T13998 1149-1160 JJ denotes significant
T13999 1161-1172 NN denotes improvement
T14000 1173-1175 IN denotes by
T14001 1176-1179 DT denotes the
T14002 1180-1193 NN denotes incorporation
T14003 1194-1196 IN denotes of
T14004 1197-1200 NN denotes sex
T14005 1201-1209 JJ denotes additive
T14006 1200-1201 HYPH denotes *
T14007 1227-1237 NNS denotes parameters
T14008 1210-1213 CC denotes and
T14009 1214-1217 NN denotes sex
T14010 1218-1226 JJ denotes dominant
T14011 1217-1218 HYPH denotes *
T14012 1237-1238 . denotes .
T14013 1238-1487 sentence denotes QTLs associated with obesity, gonadal fat, and abdominal fat have been reported before overlapping with cQTLs on Chromosomes 1 [26–28], 5 [26,29], and 11 [19,29] reported here, whereas the cQTL on Chromosome 3 represents a novel QTL for this trait.
T14014 1239-1243 NNS denotes QTLs
T14015 1326-1337 VBG denotes overlapping
T14016 1244-1254 VBN denotes associated
T14017 1255-1259 IN denotes with
T14018 1260-1267 NN denotes obesity
T14019 1267-1269 , denotes ,
T14020 1269-1276 JJ denotes gonadal
T14021 1277-1280 NN denotes fat
T14022 1280-1282 , denotes ,
T14023 1282-1285 CC denotes and
T14024 1286-1295 JJ denotes abdominal
T14025 1296-1299 NN denotes fat
T14026 1300-1304 VBP denotes have
T14027 1305-1309 VBN denotes been
T14028 1310-1318 VBN denotes reported
T14029 1319-1325 RB denotes before
T14030 1338-1342 IN denotes with
T14031 1343-1348 NNS denotes cQTLs
T14032 1349-1351 IN denotes on
T14033 1352-1363 NNS denotes Chromosomes
T14034 1364-1365 CD denotes 1
T14035 1366-1367 -LRB- denotes [
T14036 1367-1369 CD denotes 26
T14037 1369-1370 SYM denotes –
T14038 1370-1372 CD denotes 28
T14039 1372-1373 -RRB- denotes ]
T14040 1373-1375 , denotes ,
T14041 1375-1376 CD denotes 5
T14042 1377-1378 -LRB- denotes [
T14043 1381-1383 CD denotes 29
T14044 1378-1380 CD denotes 26
T14045 1380-1381 , denotes ,
T14046 1383-1384 -RRB- denotes ]
T14047 1384-1386 , denotes ,
T14048 1386-1389 CC denotes and
T14049 1390-1392 CD denotes 11
T14050 1393-1394 -LRB- denotes [
T14051 1397-1399 CD denotes 29
T14052 1394-1396 CD denotes 19
T14053 1396-1397 , denotes ,
T14054 1399-1400 -RRB- denotes ]
T14055 1401-1409 VBN denotes reported
T14056 1410-1414 RB denotes here
T14057 1414-1416 , denotes ,
T14058 1416-1423 IN denotes whereas
T14059 1449-1459 VBZ denotes represents
T14060 1424-1427 DT denotes the
T14061 1428-1432 NN denotes cQTL
T14062 1433-1435 IN denotes on
T14063 1436-1446 NN denotes Chromosome
T14064 1447-1448 CD denotes 3
T14065 1460-1461 DT denotes a
T14066 1468-1471 NN denotes QTL
T14067 1462-1467 JJ denotes novel
T14068 1472-1475 IN denotes for
T14069 1476-1480 DT denotes this
T14070 1481-1486 NN denotes trait
T14071 1486-1487 . denotes .
T14072 1487-1703 sentence denotes The Chromosome 19 cQTL for fat mass was recently reported by us [5] in the BXD intercross F2 progeny from the strains B6 and DBA (which shares the same haplotype at this region as the C3H strain used in this study).
T14073 1488-1491 DT denotes The
T14074 1506-1510 NN denotes cQTL
T14075 1492-1502 NN denotes Chromosome
T14076 1503-1505 CD denotes 19
T14077 1537-1545 VBN denotes reported
T14078 1511-1514 IN denotes for
T14079 1515-1518 NN denotes fat
T14080 1519-1523 NN denotes mass
T14081 1524-1527 VBD denotes was
T14082 1528-1536 RB denotes recently
T14083 1546-1548 IN denotes by
T14084 1549-1551 PRP denotes us
T14085 1552-1553 -LRB- denotes [
T14086 1553-1554 CD denotes 5
T14087 1554-1555 -RRB- denotes ]
T14088 1556-1558 IN denotes in
T14089 1559-1562 DT denotes the
T14090 1581-1588 NN denotes progeny
T14091 1563-1566 NN denotes BXD
T14092 1567-1577 NN denotes intercross
T14093 1578-1580 NN denotes F2
T14094 1589-1593 IN denotes from
T14095 1594-1597 DT denotes the
T14096 1598-1605 NNS denotes strains
T14097 1606-1608 NN denotes B6
T14098 1609-1612 CC denotes and
T14099 1613-1616 NN denotes DBA
T14100 1617-1618 -LRB- denotes (
T14101 1618-1623 WDT denotes which
T14102 1624-1630 VBZ denotes shares
T14103 1631-1634 DT denotes the
T14104 1640-1649 NN denotes haplotype
T14105 1635-1639 JJ denotes same
T14106 1650-1652 IN denotes at
T14107 1653-1657 DT denotes this
T14108 1658-1664 NN denotes region
T14109 1665-1667 IN denotes as
T14110 1668-1671 DT denotes the
T14111 1676-1682 NN denotes strain
T14112 1672-1675 NN denotes C3H
T14113 1683-1687 VBN denotes used
T14114 1688-1690 IN denotes in
T14115 1691-1695 DT denotes this
T14116 1696-1701 NN denotes study
T14117 1701-1702 -RRB- denotes )
T14118 1702-1703 . denotes .
T14119 1703-1891 sentence denotes Interestingly, significant heritability and genetic regulation was seen in this F2 population despite the hyperlipidemic, proinflammatory ApoE−/− background and the high-fat Western diet.
T14120 1704-1717 RB denotes Interestingly
T14121 1771-1775 VBN denotes seen
T14122 1717-1719 , denotes ,
T14123 1719-1730 JJ denotes significant
T14124 1731-1743 NN denotes heritability
T14125 1744-1747 CC denotes and
T14126 1748-1755 JJ denotes genetic
T14127 1756-1766 NN denotes regulation
T14128 1767-1770 VBD denotes was
T14129 1776-1778 IN denotes in
T14130 1779-1783 DT denotes this
T14131 1787-1797 NN denotes population
T14132 1784-1786 NN denotes F2
T14133 1798-1805 IN denotes despite
T14134 1806-1809 DT denotes the
T14135 1850-1860 NN denotes background
T14136 1810-1824 JJ denotes hyperlipidemic
T14137 1824-1826 , denotes ,
T14138 1826-1841 JJ denotes proinflammatory
T14139 1842-1846 NN denotes ApoE
T14140 1846-1847 SYM denotes −
T14141 1847-1848 HYPH denotes /
T14142 1848-1849 SYM denotes −
T14143 1861-1864 CC denotes and
T14144 1865-1868 DT denotes the
T14145 1886-1890 NN denotes diet
T14146 1869-1873 JJ denotes high
T14147 1874-1877 NN denotes fat
T14148 1873-1874 HYPH denotes -
T14149 1878-1885 NNP denotes Western
T14150 1890-1891 . denotes .
T14151 1891-1997 sentence denotes This background possesses several advantages, such as allowing the modeling of human-like disease states.
T14152 1892-1896 DT denotes This
T14153 1897-1907 NN denotes background
T14154 1908-1917 VBZ denotes possesses
T14155 1918-1925 JJ denotes several
T14156 1926-1936 NNS denotes advantages
T14157 1936-1938 , denotes ,
T14158 1938-1942 JJ denotes such
T14159 1943-1945 IN denotes as
T14160 1946-1954 VBG denotes allowing
T14161 1955-1958 DT denotes the
T14162 1959-1967 NN denotes modeling
T14163 1968-1970 IN denotes of
T14164 1971-1976 JJ denotes human
T14165 1977-1981 JJ denotes like
T14166 1976-1977 HYPH denotes -
T14167 1990-1996 NNS denotes states
T14168 1982-1989 NN denotes disease
T14169 1996-1997 . denotes .
T14170 1997-2185 sentence denotes The predominantly female-driven effects of the five cQTLs likely reflect the significant effect of differential gonadal hormone secretions on the genetic regulation of this complex trait.
T14171 1998-2001 DT denotes The
T14172 2030-2037 NNS denotes effects
T14173 2002-2015 RB denotes predominantly
T14174 2023-2029 VBN denotes driven
T14175 2016-2022 JJ denotes female
T14176 2022-2023 HYPH denotes -
T14177 2063-2070 VBP denotes reflect
T14178 2038-2040 IN denotes of
T14179 2041-2044 DT denotes the
T14180 2050-2055 NNS denotes cQTLs
T14181 2045-2049 CD denotes five
T14182 2056-2062 RB denotes likely
T14183 2071-2074 DT denotes the
T14184 2087-2093 NN denotes effect
T14185 2075-2086 JJ denotes significant
T14186 2094-2096 IN denotes of
T14187 2097-2109 JJ denotes differential
T14188 2126-2136 NNS denotes secretions
T14189 2110-2117 JJ denotes gonadal
T14190 2118-2125 NN denotes hormone
T14191 2137-2139 IN denotes on
T14192 2140-2143 DT denotes the
T14193 2152-2162 NN denotes regulation
T14194 2144-2151 JJ denotes genetic
T14195 2163-2165 IN denotes of
T14196 2166-2170 DT denotes this
T14197 2179-2184 NN denotes trait
T14198 2171-2178 JJ denotes complex
T14199 2184-2185 . denotes .
T14200 2185-2251 sentence denotes The identification of genes underlying cQTLs remains a challenge.
T14201 2186-2189 DT denotes The
T14202 2190-2204 NN denotes identification
T14203 2231-2238 VBZ denotes remains
T14204 2205-2207 IN denotes of
T14205 2208-2213 NNS denotes genes
T14206 2214-2224 VBG denotes underlying
T14207 2225-2230 NNS denotes cQTLs
T14208 2239-2240 DT denotes a
T14209 2241-2250 NN denotes challenge
T14210 2250-2251 . denotes .
T14211 2251-2488 sentence denotes The widespread availability of genome-wide expression analysis has begun to address this by providing a snapshot of transcription in relevant organs and thus providing initial information for which genes can differentiate a given trait.
T14212 2252-2255 DT denotes The
T14213 2267-2279 NN denotes availability
T14214 2256-2266 JJ denotes widespread
T14215 2319-2324 VBN denotes begun
T14216 2280-2282 IN denotes of
T14217 2283-2289 NN denotes genome
T14218 2290-2294 JJ denotes wide
T14219 2289-2290 HYPH denotes -
T14220 2306-2314 NN denotes analysis
T14221 2295-2305 NN denotes expression
T14222 2315-2318 VBZ denotes has
T14223 2325-2327 TO denotes to
T14224 2328-2335 VB denotes address
T14225 2336-2340 DT denotes this
T14226 2341-2343 IN denotes by
T14227 2344-2353 VBG denotes providing
T14228 2354-2355 DT denotes a
T14229 2356-2364 NN denotes snapshot
T14230 2365-2367 IN denotes of
T14231 2368-2381 NN denotes transcription
T14232 2382-2384 IN denotes in
T14233 2385-2393 JJ denotes relevant
T14234 2394-2400 NNS denotes organs
T14235 2401-2404 CC denotes and
T14236 2405-2409 RB denotes thus
T14237 2410-2419 VBG denotes providing
T14238 2420-2427 JJ denotes initial
T14239 2428-2439 NN denotes information
T14240 2440-2443 IN denotes for
T14241 2444-2449 WDT denotes which
T14242 2450-2455 NNS denotes genes
T14243 2460-2473 VB denotes differentiate
T14244 2456-2459 MD denotes can
T14245 2474-2475 DT denotes a
T14246 2482-2487 NN denotes trait
T14247 2476-2481 JJ denotes given
T14248 2487-2488 . denotes .
T14249 2488-2638 sentence denotes Furthermore, by treating transcript levels as quantitative traits, we can map the genetic regulation underlying differential gene expression (eQTLs).
T14250 2489-2500 RB denotes Furthermore
T14251 2563-2566 VB denotes map
T14252 2500-2502 , denotes ,
T14253 2502-2504 IN denotes by
T14254 2505-2513 VBG denotes treating
T14255 2514-2524 NN denotes transcript
T14256 2525-2531 NNS denotes levels
T14257 2532-2534 IN denotes as
T14258 2535-2547 JJ denotes quantitative
T14259 2548-2554 NNS denotes traits
T14260 2554-2556 , denotes ,
T14261 2556-2558 PRP denotes we
T14262 2559-2562 MD denotes can
T14263 2567-2570 DT denotes the
T14264 2579-2589 NN denotes regulation
T14265 2571-2578 JJ denotes genetic
T14266 2590-2600 VBG denotes underlying
T14267 2601-2613 JJ denotes differential
T14268 2619-2629 NN denotes expression
T14269 2614-2618 NN denotes gene
T14270 2630-2631 -LRB- denotes (
T14271 2631-2636 NNS denotes eQTLs
T14272 2636-2637 -RRB- denotes )
T14273 2637-2638 . denotes .
T14274 2638-2757 sentence denotes Those eQTLs that have cis-acting variations affecting their transcription are potential candidate genes for the trait.
T14275 2639-2644 DT denotes Those
T14276 2645-2650 NNS denotes eQTLs
T14277 2713-2716 VBP denotes are
T14278 2651-2655 WDT denotes that
T14279 2656-2660 VBP denotes have
T14280 2661-2664 NN denotes cis
T14281 2665-2671 VBG denotes acting
T14282 2664-2665 HYPH denotes -
T14283 2672-2682 NNS denotes variations
T14284 2683-2692 VBG denotes affecting
T14285 2693-2698 PRP$ denotes their
T14286 2699-2712 NN denotes transcription
T14287 2717-2726 JJ denotes potential
T14288 2737-2742 NNS denotes genes
T14289 2727-2736 NN denotes candidate
T14290 2743-2746 IN denotes for
T14291 2747-2750 DT denotes the
T14292 2751-2756 NN denotes trait
T14293 2756-2757 . denotes .
T14294 2757-2898 sentence denotes At a single trait, genome-wide significance level of 0.05, we detected 6,676 eQTLs representing 4,998 genes, of which 2,118 were cis-acting.
T14295 2758-2760 IN denotes At
T14296 2820-2828 VBD denotes detected
T14297 2761-2762 DT denotes a
T14298 2802-2807 NN denotes level
T14299 2763-2769 JJ denotes single
T14300 2770-2775 NN denotes trait
T14301 2775-2777 , denotes ,
T14302 2777-2783 NN denotes genome
T14303 2784-2788 JJ denotes wide
T14304 2783-2784 HYPH denotes -
T14305 2789-2801 NN denotes significance
T14306 2808-2810 IN denotes of
T14307 2811-2815 CD denotes 0.05
T14308 2815-2817 , denotes ,
T14309 2817-2819 PRP denotes we
T14310 2829-2834 CD denotes 6,676
T14311 2835-2840 NNS denotes eQTLs
T14312 2841-2853 VBG denotes representing
T14313 2854-2859 CD denotes 4,998
T14314 2860-2865 NNS denotes genes
T14315 2865-2867 , denotes ,
T14316 2867-2869 IN denotes of
T14317 2882-2886 VBD denotes were
T14318 2870-2875 WDT denotes which
T14319 2876-2881 CD denotes 2,118
T14320 2887-2890 NN denotes cis
T14321 2891-2897 VBG denotes acting
T14322 2890-2891 HYPH denotes -
T14323 2897-2898 . denotes .
T14324 2898-3115 sentence denotes At increased thresholds, the proportion of cis-eQTLs increased, which is in good agreement with previous studies [5,15] and likely reflects the increased power to detect cis-acting variations affecting transcription.
T14325 2899-2901 IN denotes At
T14326 2952-2961 VBD denotes increased
T14327 2902-2911 VBN denotes increased
T14328 2912-2922 NNS denotes thresholds
T14329 2922-2924 , denotes ,
T14330 2924-2927 DT denotes the
T14331 2928-2938 NN denotes proportion
T14332 2939-2941 IN denotes of
T14333 2942-2945 NN denotes cis
T14334 2946-2951 NNS denotes eQTLs
T14335 2945-2946 HYPH denotes -
T14336 2961-2963 , denotes ,
T14337 2963-2968 WDT denotes which
T14338 2969-2971 VBZ denotes is
T14339 2972-2974 IN denotes in
T14340 2975-2979 JJ denotes good
T14341 2980-2989 NN denotes agreement
T14342 2990-2994 IN denotes with
T14343 2995-3003 JJ denotes previous
T14344 3004-3011 NNS denotes studies
T14345 3012-3013 -LRB- denotes [
T14346 3015-3017 CD denotes 15
T14347 3013-3014 CD denotes 5
T14348 3014-3015 , denotes ,
T14349 3017-3018 -RRB- denotes ]
T14350 3019-3022 CC denotes and
T14351 3023-3029 RB denotes likely
T14352 3030-3038 VBZ denotes reflects
T14353 3039-3042 DT denotes the
T14354 3053-3058 NN denotes power
T14355 3043-3052 VBN denotes increased
T14356 3059-3061 TO denotes to
T14357 3062-3068 VB denotes detect
T14358 3069-3072 NN denotes cis
T14359 3073-3079 VBG denotes acting
T14360 3072-3073 HYPH denotes -
T14361 3080-3090 NNS denotes variations
T14362 3091-3100 VBG denotes affecting
T14363 3101-3114 NN denotes transcription
T14364 3114-3115 . denotes .
T14365 3115-3193 sentence denotes Of all 6,676 significant eQTLs, 1,166 possessed significant sex interactions.
T14366 3116-3118 IN denotes Of
T14367 3154-3163 VBD denotes possessed
T14368 3119-3122 DT denotes all
T14369 3141-3146 NNS denotes eQTLs
T14370 3123-3128 CD denotes 6,676
T14371 3129-3140 JJ denotes significant
T14372 3146-3148 , denotes ,
T14373 3148-3153 CD denotes 1,166
T14374 3164-3175 JJ denotes significant
T14375 3180-3192 NNS denotes interactions
T14376 3176-3179 NN denotes sex
T14377 3192-3193 . denotes .
T14378 3193-3385 sentence denotes Of these, 304 were cis and 852 were trans, suggesting that only a minority of the sex-specific effects on the regulation of gene expression occur through polymorphisms within the gene itself.
T14379 3194-3196 IN denotes Of
T14380 3208-3212 VBD denotes were
T14381 3197-3202 DT denotes these
T14382 3202-3204 , denotes ,
T14383 3204-3207 CD denotes 304
T14384 3213-3216 NN denotes cis
T14385 3217-3220 CC denotes and
T14386 3221-3224 CD denotes 852
T14387 3225-3229 VBD denotes were
T14388 3230-3235 NN denotes trans
T14389 3235-3237 , denotes ,
T14390 3237-3247 VBG denotes suggesting
T14391 3248-3252 IN denotes that
T14392 3334-3339 VBP denotes occur
T14393 3253-3257 RB denotes only
T14394 3260-3268 NN denotes minority
T14395 3258-3259 DT denotes a
T14396 3269-3271 IN denotes of
T14397 3272-3275 DT denotes the
T14398 3289-3296 NNS denotes effects
T14399 3276-3279 NN denotes sex
T14400 3280-3288 JJ denotes specific
T14401 3279-3280 HYPH denotes -
T14402 3297-3299 IN denotes on
T14403 3300-3303 DT denotes the
T14404 3304-3314 NN denotes regulation
T14405 3315-3317 IN denotes of
T14406 3318-3322 NN denotes gene
T14407 3323-3333 NN denotes expression
T14408 3340-3347 IN denotes through
T14409 3348-3361 NNS denotes polymorphisms
T14410 3362-3368 IN denotes within
T14411 3369-3372 DT denotes the
T14412 3373-3377 NN denotes gene
T14413 3378-3384 PRP denotes itself
T14414 3384-3385 . denotes .
T14415 3385-3535 sentence denotes Rather, underlying genetic regulation of most transcripts is the result of interactions between trans loci and sex-specific factors (e.g., hormones).
T14416 3386-3392 RB denotes Rather
T14417 3444-3446 VBZ denotes is
T14418 3392-3394 , denotes ,
T14419 3394-3404 VBG denotes underlying
T14420 3413-3423 NN denotes regulation
T14421 3405-3412 JJ denotes genetic
T14422 3424-3426 IN denotes of
T14423 3427-3431 JJS denotes most
T14424 3432-3443 NNS denotes transcripts
T14425 3447-3450 DT denotes the
T14426 3451-3457 NN denotes result
T14427 3458-3460 IN denotes of
T14428 3461-3473 NNS denotes interactions
T14429 3474-3481 IN denotes between
T14430 3482-3487 NN denotes trans
T14431 3488-3492 NNS denotes loci
T14432 3493-3496 CC denotes and
T14433 3497-3500 NN denotes sex
T14434 3501-3509 JJ denotes specific
T14435 3500-3501 HYPH denotes -
T14436 3510-3517 NNS denotes factors
T14437 3518-3519 -LRB- denotes (
T14438 3519-3523 FW denotes e.g.
T14439 3525-3533 NNS denotes hormones
T14440 3523-3525 , denotes ,
T14441 3533-3534 -RRB- denotes )
T14442 3534-3535 . denotes .
T14443 3535-3679 sentence denotes As with cQTLs, sex bias in the predominantly trans genetic regulation of gene expression is likely secondary to different sex hormone profiles.
T14444 3536-3538 IN denotes As
T14445 3625-3627 VBZ denotes is
T14446 3539-3543 IN denotes with
T14447 3544-3549 NNS denotes cQTLs
T14448 3549-3551 , denotes ,
T14449 3551-3554 NN denotes sex
T14450 3555-3559 NN denotes bias
T14451 3560-3562 IN denotes in
T14452 3563-3566 DT denotes the
T14453 3595-3605 NN denotes regulation
T14454 3567-3580 RB denotes predominantly
T14455 3581-3586 JJ denotes trans
T14456 3587-3594 JJ denotes genetic
T14457 3606-3608 IN denotes of
T14458 3609-3613 NN denotes gene
T14459 3614-3624 NN denotes expression
T14460 3628-3634 RB denotes likely
T14461 3635-3644 JJ denotes secondary
T14462 3645-3647 IN denotes to
T14463 3648-3657 JJ denotes different
T14464 3670-3678 NNS denotes profiles
T14465 3658-3661 NN denotes sex
T14466 3662-3669 NN denotes hormone
T14467 3678-3679 . denotes .
T14468 3679-3888 sentence denotes Recently, using a similar dataset, our group demonstrated that significant cis-eQTLs (p < 5 × 10−5) largely represent true positives [30] and are enriched for highly polymorphic regions over the mouse genome.
T14469 3680-3688 RB denotes Recently
T14470 3725-3737 VBD denotes demonstrated
T14471 3688-3690 , denotes ,
T14472 3690-3695 VBG denotes using
T14473 3696-3697 DT denotes a
T14474 3706-3713 NN denotes dataset
T14475 3698-3705 JJ denotes similar
T14476 3713-3715 , denotes ,
T14477 3715-3718 PRP$ denotes our
T14478 3719-3724 NN denotes group
T14479 3738-3742 IN denotes that
T14480 3788-3797 VBP denotes represent
T14481 3743-3754 JJ denotes significant
T14482 3759-3764 NNS denotes eQTLs
T14483 3755-3758 NN denotes cis
T14484 3758-3759 HYPH denotes -
T14485 3765-3766 -LRB- denotes (
T14486 3770-3771 CD denotes 5
T14487 3766-3767 NN denotes p
T14488 3768-3769 SYM denotes <
T14489 3772-3773 SYM denotes ×
T14490 3774-3776 CD denotes 10
T14491 3777-3778 CD denotes 5
T14492 3776-3777 SYM denotes −
T14493 3778-3779 -RRB- denotes )
T14494 3780-3787 RB denotes largely
T14495 3798-3802 JJ denotes true
T14496 3803-3812 NNS denotes positives
T14497 3813-3814 -LRB- denotes [
T14498 3814-3816 CD denotes 30
T14499 3816-3817 -RRB- denotes ]
T14500 3818-3821 CC denotes and
T14501 3822-3825 VBP denotes are
T14502 3826-3834 JJ denotes enriched
T14503 3835-3838 IN denotes for
T14504 3839-3845 RB denotes highly
T14505 3846-3857 JJ denotes polymorphic
T14506 3858-3865 NNS denotes regions
T14507 3866-3870 IN denotes over
T14508 3871-3874 DT denotes the
T14509 3881-3887 NN denotes genome
T14510 3875-3880 NN denotes mouse
T14511 3887-3888 . denotes .
T14512 3888-4017 sentence denotes The cis-eQTLs presented in Table 5 overlap with one of the gonadal fat mass cQTLs and should be considered potential candidates.
T14513 3889-3892 DT denotes The
T14514 3897-3902 NNS denotes eQTLs
T14515 3893-3896 NN denotes cis
T14516 3896-3897 HYPH denotes -
T14517 3924-3931 VBP denotes overlap
T14518 3903-3912 VBN denotes presented
T14519 3913-3915 IN denotes in
T14520 3916-3921 NN denotes Table
T14521 3922-3923 CD denotes 5
T14522 3932-3936 IN denotes with
T14523 3937-3940 CD denotes one
T14524 3941-3943 IN denotes of
T14525 3944-3947 DT denotes the
T14526 3965-3970 NNS denotes cQTLs
T14527 3948-3955 JJ denotes gonadal
T14528 3960-3964 NN denotes mass
T14529 3956-3959 NN denotes fat
T14530 3971-3974 CC denotes and
T14531 3975-3981 MD denotes should
T14532 3985-3995 VBN denotes considered
T14533 3982-3984 VB denotes be
T14534 3996-4005 JJ denotes potential
T14535 4006-4016 NNS denotes candidates
T14536 4016-4017 . denotes .
T14537 4017-4195 sentence denotes Given the sex effects in the gonadal fat mass cQTLs, we reasoned that the cis-eQTLs with significant sex*additive and sex*dominant effects should receive priority consideration.
T14538 4018-4023 IN denotes Given
T14539 4074-4082 VBD denotes reasoned
T14540 4024-4027 DT denotes the
T14541 4032-4039 NNS denotes effects
T14542 4028-4031 NN denotes sex
T14543 4040-4042 IN denotes in
T14544 4043-4046 DT denotes the
T14545 4064-4069 NNS denotes cQTLs
T14546 4047-4054 JJ denotes gonadal
T14547 4059-4063 NN denotes mass
T14548 4055-4058 NN denotes fat
T14549 4069-4071 , denotes ,
T14550 4071-4073 PRP denotes we
T14551 4083-4087 IN denotes that
T14552 4164-4171 VB denotes receive
T14553 4088-4091 DT denotes the
T14554 4096-4101 NNS denotes eQTLs
T14555 4092-4095 NN denotes cis
T14556 4095-4096 HYPH denotes -
T14557 4102-4106 IN denotes with
T14558 4107-4118 JJ denotes significant
T14559 4149-4156 NNS denotes effects
T14560 4119-4122 NN denotes sex
T14561 4123-4131 JJ denotes additive
T14562 4122-4123 HYPH denotes *
T14563 4132-4135 CC denotes and
T14564 4136-4139 NN denotes sex
T14565 4140-4148 JJ denotes dominant
T14566 4139-4140 HYPH denotes *
T14567 4157-4163 MD denotes should
T14568 4172-4180 NN denotes priority
T14569 4181-4194 NN denotes consideration
T14570 4194-4195 . denotes .
T14571 4195-4306 sentence denotes The use of eQTLs to dissect cQTLs is a method still in its infancy, with uncertain efficacy and applicability.
T14572 4196-4199 DT denotes The
T14573 4200-4203 NN denotes use
T14574 4230-4232 VBZ denotes is
T14575 4204-4206 IN denotes of
T14576 4207-4212 NNS denotes eQTLs
T14577 4213-4215 TO denotes to
T14578 4216-4223 VB denotes dissect
T14579 4224-4229 NNS denotes cQTLs
T14580 4233-4234 DT denotes a
T14581 4235-4241 NN denotes method
T14582 4242-4247 RB denotes still
T14583 4248-4250 IN denotes in
T14584 4251-4254 PRP$ denotes its
T14585 4255-4262 NN denotes infancy
T14586 4262-4264 , denotes ,
T14587 4264-4268 IN denotes with
T14588 4269-4278 JJ denotes uncertain
T14589 4279-4287 NN denotes efficacy
T14590 4288-4291 CC denotes and
T14591 4292-4305 NN denotes applicability
T14592 4305-4306 . denotes .
T14593 4306-4421 sentence denotes Nevertheless, application of this analysis to this dataset provides some tantalizingly attractive candidate genes.
T14594 4307-4319 RB denotes Nevertheless
T14595 4366-4374 VBZ denotes provides
T14596 4319-4321 , denotes ,
T14597 4321-4332 NN denotes application
T14598 4333-4335 IN denotes of
T14599 4336-4340 DT denotes this
T14600 4341-4349 NN denotes analysis
T14601 4350-4352 IN denotes to
T14602 4353-4357 DT denotes this
T14603 4358-4365 NN denotes dataset
T14604 4375-4379 DT denotes some
T14605 4415-4420 NNS denotes genes
T14606 4380-4393 RB denotes tantalizingly
T14607 4394-4404 JJ denotes attractive
T14608 4405-4414 NN denotes candidate
T14609 4420-4421 . denotes .
T14610 4421-4698 sentence denotes One shortcoming of this approach, however, is that candidate genes are limited to those whose transcript expression levels vary in association with a nearby polymorphism that differs between the parental strains—in other words, genes with significant and detectable cis-eQTLs.
T14611 4422-4425 CD denotes One
T14612 4426-4437 NN denotes shortcoming
T14613 4465-4467 VBZ denotes is
T14614 4438-4440 IN denotes of
T14615 4441-4445 DT denotes this
T14616 4446-4454 NN denotes approach
T14617 4454-4456 , denotes ,
T14618 4456-4463 RB denotes however
T14619 4463-4465 , denotes ,
T14620 4468-4472 IN denotes that
T14621 4493-4500 VBN denotes limited
T14622 4473-4482 NN denotes candidate
T14623 4483-4488 NNS denotes genes
T14624 4489-4492 VBP denotes are
T14625 4501-4503 IN denotes to
T14626 4504-4509 DT denotes those
T14627 4510-4515 WP$ denotes whose
T14628 4538-4544 NNS denotes levels
T14629 4516-4526 NN denotes transcript
T14630 4527-4537 NN denotes expression
T14631 4545-4549 VBP denotes vary
T14632 4550-4552 IN denotes in
T14633 4553-4564 NN denotes association
T14634 4565-4569 IN denotes with
T14635 4570-4571 DT denotes a
T14636 4579-4591 NN denotes polymorphism
T14637 4572-4578 JJ denotes nearby
T14638 4592-4596 WDT denotes that
T14639 4597-4604 VBZ denotes differs
T14640 4605-4612 IN denotes between
T14641 4613-4616 DT denotes the
T14642 4626-4633 NNS denotes strains
T14643 4617-4625 JJ denotes parental
T14644 4633-4634 : denotes —
T14645 4634-4636 IN denotes in
T14646 4650-4655 NNS denotes genes
T14647 4637-4642 JJ denotes other
T14648 4643-4648 NNS denotes words
T14649 4648-4650 , denotes ,
T14650 4656-4660 IN denotes with
T14651 4661-4672 JJ denotes significant
T14652 4692-4697 NNS denotes eQTLs
T14653 4673-4676 CC denotes and
T14654 4677-4687 JJ denotes detectable
T14655 4688-4691 NN denotes cis
T14656 4691-4692 HYPH denotes -
T14657 4697-4698 . denotes .
T14658 4698-4889 sentence denotes However, it is not strictly necessary for candidate genes to have evidence of such linkage: polymorphisms underlying a trait cQTL can affect gene function or posttranslational modifications.
T14659 4699-4706 RB denotes However
T14660 4711-4713 VBZ denotes is
T14661 4706-4708 , denotes ,
T14662 4708-4710 PRP denotes it
T14663 4833-4839 VB denotes affect
T14664 4714-4717 RB denotes not
T14665 4718-4726 RB denotes strictly
T14666 4727-4736 JJ denotes necessary
T14667 4737-4740 IN denotes for
T14668 4760-4764 VB denotes have
T14669 4741-4750 NN denotes candidate
T14670 4751-4756 NNS denotes genes
T14671 4757-4759 TO denotes to
T14672 4765-4773 NN denotes evidence
T14673 4774-4776 IN denotes of
T14674 4777-4781 JJ denotes such
T14675 4782-4789 NN denotes linkage
T14676 4789-4791 : denotes :
T14677 4791-4804 NNS denotes polymorphisms
T14678 4805-4815 VBG denotes underlying
T14679 4816-4817 DT denotes a
T14680 4824-4828 NN denotes cQTL
T14681 4818-4823 NN denotes trait
T14682 4829-4832 MD denotes can
T14683 4840-4844 NN denotes gene
T14684 4845-4853 NN denotes function
T14685 4854-4856 CC denotes or
T14686 4857-4874 JJ denotes posttranslational
T14687 4875-4888 NNS denotes modifications
T14688 4888-4889 . denotes .
T14689 4889-5073 sentence denotes Nevertheless, several phenotypes are known to be regulated, at least partly, at the level of transcription or mRNA stability, which is exactly what our methods are designed to detect.
T14690 4890-4902 RB denotes Nevertheless
T14691 4927-4932 VBN denotes known
T14692 4902-4904 , denotes ,
T14693 4904-4911 JJ denotes several
T14694 4912-4922 NNS denotes phenotypes
T14695 4923-4926 VBP denotes are
T14696 4933-4935 TO denotes to
T14697 4939-4948 VBN denotes regulated
T14698 4936-4938 VB denotes be
T14699 4948-4950 , denotes ,
T14700 4950-4952 RB denotes at
T14701 4953-4958 RBS denotes least
T14702 4959-4965 RB denotes partly
T14703 4967-4969 IN denotes at
T14704 4965-4967 , denotes ,
T14705 4970-4973 DT denotes the
T14706 4974-4979 NN denotes level
T14707 4980-4982 IN denotes of
T14708 4983-4996 NN denotes transcription
T14709 4997-4999 CC denotes or
T14710 5000-5004 NN denotes mRNA
T14711 5005-5014 NN denotes stability
T14712 5014-5016 , denotes ,
T14713 5016-5021 WDT denotes which
T14714 5022-5024 VBZ denotes is
T14715 5025-5032 RB denotes exactly
T14716 5033-5037 WP denotes what
T14717 5054-5062 VBN denotes designed
T14718 5038-5041 PRP$ denotes our
T14719 5042-5049 NNS denotes methods
T14720 5050-5053 VBP denotes are
T14721 5063-5065 TO denotes to
T14722 5066-5072 VB denotes detect
T14723 5072-5073 . denotes .
T14724 5073-5273 sentence denotes A separate problem is that organ-specific gene expression differences may preclude one from detecting the relevant causative gene if the tissue arrayed is not the tissue where the control is exerted.
T14725 5074-5075 DT denotes A
T14726 5085-5092 NN denotes problem
T14727 5076-5084 JJ denotes separate
T14728 5093-5095 VBZ denotes is
T14729 5096-5100 IN denotes that
T14730 5148-5156 VB denotes preclude
T14731 5101-5106 NN denotes organ
T14732 5107-5115 JJ denotes specific
T14733 5106-5107 HYPH denotes -
T14734 5132-5143 NNS denotes differences
T14735 5116-5120 NN denotes gene
T14736 5121-5131 NN denotes expression
T14737 5144-5147 MD denotes may
T14738 5157-5160 PRP denotes one
T14739 5161-5165 IN denotes from
T14740 5166-5175 VBG denotes detecting
T14741 5176-5179 DT denotes the
T14742 5199-5203 NN denotes gene
T14743 5180-5188 JJ denotes relevant
T14744 5189-5198 JJ denotes causative
T14745 5204-5206 IN denotes if
T14746 5226-5228 VBZ denotes is
T14747 5207-5210 DT denotes the
T14748 5211-5217 NN denotes tissue
T14749 5218-5225 VBN denotes arrayed
T14750 5229-5232 RB denotes not
T14751 5233-5236 DT denotes the
T14752 5237-5243 NN denotes tissue
T14753 5244-5249 WRB denotes where
T14754 5265-5272 VBN denotes exerted
T14755 5250-5253 DT denotes the
T14756 5254-5261 NN denotes control
T14757 5262-5264 VBZ denotes is
T14758 5272-5273 . denotes .
T14759 5273-5385 sentence denotes This is particularly relevant for a trait such as adipose tissue mass, which is controlled by multiple tissues.
T14760 5274-5278 DT denotes This
T14761 5279-5281 VBZ denotes is
T14762 5282-5294 RB denotes particularly
T14763 5295-5303 JJ denotes relevant
T14764 5304-5307 IN denotes for
T14765 5308-5309 DT denotes a
T14766 5310-5315 NN denotes trait
T14767 5316-5320 JJ denotes such
T14768 5321-5323 IN denotes as
T14769 5324-5331 NN denotes adipose
T14770 5339-5343 NN denotes mass
T14771 5332-5338 NN denotes tissue
T14772 5343-5345 , denotes ,
T14773 5345-5350 WDT denotes which
T14774 5354-5364 VBN denotes controlled
T14775 5351-5353 VBZ denotes is
T14776 5365-5367 IN denotes by
T14777 5368-5376 JJ denotes multiple
T14778 5377-5384 NNS denotes tissues
T14779 5384-5385 . denotes .
T14780 5385-5471 sentence denotes We propose that analysis of correlated genes can provide guidance as discussed below.
T14781 5386-5388 PRP denotes We
T14782 5389-5396 VBP denotes propose
T14783 5397-5401 IN denotes that
T14784 5435-5442 VB denotes provide
T14785 5402-5410 NN denotes analysis
T14786 5411-5413 IN denotes of
T14787 5414-5424 VBN denotes correlated
T14788 5425-5430 NNS denotes genes
T14789 5431-5434 MD denotes can
T14790 5443-5451 NN denotes guidance
T14791 5452-5454 IN denotes as
T14792 5455-5464 VBN denotes discussed
T14793 5465-5470 RB denotes below
T14794 5470-5471 . denotes .
R3817 T13776 T13777 amod Significant,Bias
R3818 T13778 T13777 compound Sex,Bias
R3819 T13779 T13777 prep in,Bias
R3820 T13780 T13781 det the,Regulation
R3821 T13781 T13779 pobj Regulation,in
R3822 T13782 T13781 prep of,Regulation
R3823 T13783 T13784 preconj Both,Traits
R3824 T13784 T13782 pobj Traits,of
R3825 T13785 T13784 amod Complex,Traits
R3826 T13786 T13784 cc and,Traits
R3827 T13787 T13788 compound Gene,Expression
R3828 T13788 T13784 conj Expression,Traits
R3829 T13790 T13791 prep Given,designed
R3830 T13792 T13793 det the,dichotomy
R3831 T13793 T13790 pobj dichotomy,Given
R3832 T13794 T13793 amod known,dichotomy
R3833 T13795 T13793 prep between,dichotomy
R3834 T13796 T13795 pobj females,between
R3835 T13797 T13796 cc and,females
R3836 T13798 T13796 conj males,females
R3837 T13799 T13793 prep in,dichotomy
R3838 T13800 T13801 det the,susceptibility
R3839 T13801 T13799 pobj susceptibility,in
R3840 T13802 T13801 cc and,susceptibility
R3841 T13803 T13801 conj control,susceptibility
R3842 T13804 T13801 prep of,susceptibility
R3843 T13805 T13804 pobj obesity,of
R3844 T13806 T13791 punct ", ",designed
R3845 T13807 T13808 det this,study
R3846 T13808 T13791 nsubjpass study,designed
R3847 T13809 T13791 auxpass was,designed
R3848 T13810 T13811 aux to,power
R3849 T13811 T13791 xcomp power,designed
R3850 T13812 T13811 advmod sufficiently,power
R3851 T13813 T13814 det the,detection
R3852 T13814 T13811 dobj detection,power
R3853 T13815 T13814 prep of,detection
R3854 T13816 T13817 amod significant,QTLs
R3855 T13817 T13815 pobj QTLs,of
R3856 T13818 T13817 prep for,QTLs
R3857 T13819 T13818 pobj this,for
R3858 T13820 T13819 cc and,this
R3859 T13821 T13822 amod other,traits
R3860 T13822 T13819 conj traits,this
R3861 T13823 T13822 prep with,traits
R3862 T13824 T13825 npadvmod sex,dependent
R3863 T13825 T13827 amod dependent,effects
R3864 T13826 T13825 punct -,dependent
R3865 T13827 T13823 pobj effects,with
R3866 T13828 T13791 punct .,designed
R3867 T13831 T13830 punct ", ",Note
R3868 T13832 T13830 advmod however,Note
R3869 T13833 T13830 punct ", ",Note
R3870 T13834 T13835 mark that,extend
R3871 T13835 T13830 ccomp extend,Note
R3872 T13836 T13837 det these,effects
R3873 T13837 T13835 nsubj effects,extend
R3874 T13838 T13835 aux can,extend
R3875 T13839 T13835 prep to,extend
R3876 T13840 T13839 pobj traits,to
R3877 T13841 T13840 prep without,traits
R3878 T13842 T13843 amod overall,differences
R3879 T13843 T13841 pobj differences,without
R3880 T13844 T13843 compound mean,differences
R3881 T13845 T13843 prep between,differences
R3882 T13846 T13847 det the,sexes
R3883 T13847 T13845 pobj sexes,between
R3884 T13848 T13830 punct .,Note
R3885 T13850 T13851 amod Previous,studies
R3886 T13851 T13852 nsubj studies,described
R3887 T13853 T13852 aux have,described
R3888 T13854 T13855 det the,advantages
R3889 T13855 T13852 dobj advantages,described
R3890 T13856 T13855 prep of,advantages
R3891 T13857 T13856 pcomp performing,of
R3892 T13858 T13859 compound QTL,analysis
R3893 T13859 T13857 dobj analysis,performing
R3894 T13860 T13861 preconj both,with
R3895 T13861 T13859 prep with,analysis
R3896 T13862 T13861 cc and,with
R3897 T13863 T13861 conj without,with
R3898 T13864 T13863 pobj sex,without
R3899 T13865 T13864 prep as,sex
R3900 T13866 T13867 det an,covariate
R3901 T13867 T13865 pobj covariate,as
R3902 T13868 T13867 amod interactive,covariate
R3903 T13869 T13870 punct [,22
R3904 T13870 T13852 parataxis 22,described
R3905 T13871 T13872 punct –,25
R3906 T13872 T13870 prep 25,22
R3907 T13873 T13870 punct ],22
R3908 T13874 T13852 punct .,described
R3909 T13876 T13877 csubj Analyzing,is
R3910 T13878 T13879 det the,sexes
R3911 T13879 T13876 dobj sexes,Analyzing
R3912 T13880 T13876 advmod separately,Analyzing
R3913 T13881 T13877 acomp suboptimal,is
R3914 T13882 T13883 mark since,reduces
R3915 T13883 T13877 advcl reduces,is
R3916 T13884 T13883 nsubj it,reduces
R3917 T13885 T13886 compound sample,size
R3918 T13886 T13883 dobj size,reduces
R3919 T13887 T13883 prep in,reduces
R3920 T13888 T13889 det both,groups
R3921 T13889 T13887 pobj groups,in
R3922 T13890 T13883 punct ", ",reduces
R3923 T13891 T13892 advmod thus,reducing
R3924 T13892 T13883 advcl reducing,reduces
R3925 T13893 T13892 dobj power,reducing
R3926 T13894 T13895 aux to,detect
R3927 T13895 T13893 acl detect,power
R3928 T13896 T13897 amod main,effects
R3929 T13897 T13895 dobj effects,detect
R3930 T13898 T13897 compound QTL,effects
R3931 T13899 T13892 punct ", ",reducing
R3932 T13900 T13901 mark as,demonstrated
R3933 T13901 T13892 advcl demonstrated,reducing
R3934 T13902 T13901 agent by,demonstrated
R3935 T13903 T13904 poss our,scan
R3936 T13904 T13902 pobj scan,by
R3937 T13905 T13904 compound genome,scan
R3938 T13906 T13904 prep of,scan
R3939 T13907 T13906 pobj Chromosome,of
R3940 T13908 T13907 nummod 5,Chromosome
R3941 T13909 T13910 punct (,1B
R3942 T13910 T13877 parataxis 1B,is
R3943 T13911 T13910 compound Figure,1B
R3944 T13912 T13910 punct ),1B
R3945 T13913 T13877 punct .,is
R3946 T13915 T13916 advmod Furthermore,allow
R3947 T13917 T13916 punct ", ",allow
R3948 T13918 T13919 amod separate,analyses
R3949 T13919 T13916 nsubj analyses,allow
R3950 T13920 T13916 aux would,allow
R3951 T13921 T13916 neg not,allow
R3952 T13922 T13916 prep for,allow
R3953 T13923 T13924 det the,detection
R3954 T13924 T13922 pobj detection,for
R3955 T13925 T13924 prep of,detection
R3956 T13926 T13925 pobj QTLs,of
R3957 T13927 T13928 dep that,have
R3958 T13928 T13926 relcl have,QTLs
R3959 T13929 T13930 amod opposing,effects
R3960 T13930 T13928 dobj effects,have
R3961 T13931 T13929 punct ", ",opposing
R3962 T13932 T13929 cc or,opposing
R3963 T13933 T13934 npadvmod sex,antagonistic
R3964 T13934 T13929 conj antagonistic,opposing
R3965 T13935 T13934 punct -,antagonistic
R3966 T13936 T13930 punct ", ",effects
R3967 T13937 T13928 prep in,have
R3968 T13938 T13937 pobj females,in
R3969 T13939 T13938 cc and,females
R3970 T13940 T13938 conj males,females
R3971 T13941 T13916 cc and,allow
R3972 T13942 T13943 aux would,hinder
R3973 T13943 T13916 conj hinder,allow
R3974 T13944 T13945 det the,detection
R3975 T13945 T13943 dobj detection,hinder
R3976 T13946 T13945 prep of,detection
R3977 T13947 T13946 pobj QTLs,of
R3978 T13948 T13947 amod specific,QTLs
R3979 T13949 T13948 prep to,specific
R3980 T13950 T13951 nummod one,sex
R3981 T13951 T13949 pobj sex,to
R3982 T13952 T13916 punct .,allow
R3983 T13954 T13955 advmod Accordingly,detected
R3984 T13956 T13955 punct ", ",detected
R3985 T13957 T13955 nsubj we,detected
R3986 T13958 T13959 nummod five,cQTLs
R3987 T13959 T13955 dobj cQTLs,detected
R3988 T13960 T13959 prep for,cQTLs
R3989 T13961 T13962 det the,trait
R3990 T13962 T13960 pobj trait,for
R3991 T13963 T13964 amod gonadal,mass
R3992 T13964 T13962 compound mass,trait
R3993 T13965 T13964 compound fat,mass
R3994 T13966 T13955 prep on,detected
R3995 T13967 T13968 nmod Chromosomes,1
R3996 T13968 T13966 pobj 1,on
R3997 T13969 T13968 punct ", ",1
R3998 T13970 T13968 conj 3,1
R3999 T13971 T13970 punct ", ",3
R4000 T13972 T13970 conj 5,3
R4001 T13973 T13972 punct ", ",5
R4002 T13974 T13972 conj 11,5
R4003 T13975 T13974 punct ", ",11
R4004 T13976 T13974 cc and,11
R4005 T13977 T13974 conj 19,11
R4006 T13978 T13955 punct .,detected
R4007 T13980 T13981 det The,detection
R4008 T13981 T13982 nsubjpass detection,driven
R4009 T13983 T13981 prep of,detection
R4010 T13984 T13985 det all,cQTLs
R4011 T13985 T13983 pobj cQTLs,of
R4012 T13986 T13985 nummod five,cQTLs
R4013 T13987 T13982 auxpass was,driven
R4014 T13988 T13982 punct “,driven
R4015 T13989 T13982 punct ”,driven
R4016 T13990 T13982 agent by,driven
R4017 T13991 T13992 det the,effect
R4018 T13992 T13990 pobj effect,by
R4019 T13993 T13992 amod larger,effect
R4020 T13994 T13982 prep in,driven
R4021 T13995 T13994 pobj females,in
R4022 T13996 T13982 punct ", ",driven
R4023 T13997 T13982 prep with,driven
R4024 T13998 T13999 amod significant,improvement
R4025 T13999 T13997 pobj improvement,with
R4026 T14000 T13999 prep by,improvement
R4027 T14001 T14002 det the,incorporation
R4028 T14002 T14000 pobj incorporation,by
R4029 T14003 T14002 prep of,incorporation
R4030 T14004 T14005 npadvmod sex,additive
R4031 T14005 T14007 amod additive,parameters
R4032 T14006 T14005 punct *,additive
R4033 T14007 T14003 pobj parameters,of
R4034 T14008 T14005 cc and,additive
R4035 T14009 T14010 npadvmod sex,dominant
R4036 T14010 T14005 conj dominant,additive
R4037 T14011 T14010 punct *,dominant
R4038 T14012 T13982 punct .,driven
R4039 T14014 T14015 nsubjpass QTLs,overlapping
R4040 T14016 T14014 acl associated,QTLs
R4041 T14017 T14016 prep with,associated
R4042 T14018 T14017 pobj obesity,with
R4043 T14019 T14018 punct ", ",obesity
R4044 T14020 T14021 amod gonadal,fat
R4045 T14021 T14018 conj fat,obesity
R4046 T14022 T14021 punct ", ",fat
R4047 T14023 T14021 cc and,fat
R4048 T14024 T14025 amod abdominal,fat
R4049 T14025 T14021 conj fat,fat
R4050 T14026 T14015 aux have,overlapping
R4051 T14027 T14015 auxpass been,overlapping
R4052 T14028 T14015 aux reported,overlapping
R4053 T14029 T14015 advmod before,overlapping
R4054 T14030 T14015 prep with,overlapping
R4055 T14031 T14030 pobj cQTLs,with
R4056 T14032 T14031 prep on,cQTLs
R4057 T14033 T14034 nmod Chromosomes,1
R4058 T14034 T14032 pobj 1,on
R4059 T14035 T14036 punct [,26
R4060 T14036 T14034 parataxis 26,1
R4061 T14037 T14038 punct –,28
R4062 T14038 T14036 prep 28,26
R4063 T14039 T14036 punct ],26
R4064 T14040 T14034 punct ", ",1
R4065 T14041 T14034 conj 5,1
R4066 T14042 T14043 punct [,29
R4067 T14043 T14041 parataxis 29,5
R4068 T14044 T14043 nummod 26,29
R4069 T14045 T14043 punct ",",29
R4070 T14046 T14043 punct ],29
R4071 T14047 T14041 punct ", ",5
R4072 T14048 T14041 cc and,5
R4073 T14049 T14041 conj 11,5
R4074 T14050 T14051 punct [,29
R4075 T14051 T14049 parataxis 29,11
R4076 T14052 T14051 nummod 19,29
R4077 T14053 T14051 punct ",",29
R4078 T14054 T14051 punct ],29
R4079 T14055 T14034 acl reported,1
R4080 T14056 T14055 advmod here,reported
R4081 T14057 T14015 punct ", ",overlapping
R4082 T14058 T14059 mark whereas,represents
R4083 T14059 T14015 advcl represents,overlapping
R4084 T14060 T14061 det the,cQTL
R4085 T14061 T14059 nsubj cQTL,represents
R4086 T14062 T14061 prep on,cQTL
R4087 T14063 T14062 pobj Chromosome,on
R4088 T14064 T14063 nummod 3,Chromosome
R4089 T14065 T14066 det a,QTL
R4090 T14066 T14059 dobj QTL,represents
R4091 T14067 T14066 amod novel,QTL
R4092 T14068 T14066 prep for,QTL
R4093 T14069 T14070 det this,trait
R4094 T14070 T14068 pobj trait,for
R4095 T14071 T14015 punct .,overlapping
R4096 T14073 T14074 det The,cQTL
R4097 T14074 T14077 nsubjpass cQTL,reported
R4098 T14075 T14074 nmod Chromosome,cQTL
R4099 T14076 T14075 nummod 19,Chromosome
R4100 T14078 T14074 prep for,cQTL
R4101 T14079 T14080 compound fat,mass
R4102 T14080 T14078 pobj mass,for
R4103 T14081 T14077 auxpass was,reported
R4104 T14082 T14077 advmod recently,reported
R4105 T14083 T14077 agent by,reported
R4106 T14084 T14083 pobj us,by
R4107 T14085 T14086 punct [,5
R4108 T14086 T14077 parataxis 5,reported
R4109 T14087 T14086 punct ],5
R4110 T14088 T14077 prep in,reported
R4111 T14089 T14090 det the,progeny
R4112 T14090 T14088 pobj progeny,in
R4113 T14091 T14092 compound BXD,intercross
R4114 T14092 T14090 compound intercross,progeny
R4115 T14093 T14090 compound F2,progeny
R4116 T14094 T14090 prep from,progeny
R4117 T14095 T14096 det the,strains
R4118 T14096 T14094 pobj strains,from
R4119 T14097 T14096 appos B6,strains
R4120 T14098 T14097 cc and,B6
R4121 T14099 T14097 conj DBA,B6
R4122 T14100 T14099 punct (,DBA
R4123 T14101 T14102 dep which,shares
R4124 T14102 T14099 relcl shares,DBA
R4125 T14103 T14104 det the,haplotype
R4126 T14104 T14102 dobj haplotype,shares
R4127 T14105 T14104 amod same,haplotype
R4128 T14106 T14102 prep at,shares
R4129 T14107 T14108 det this,region
R4130 T14108 T14106 pobj region,at
R4131 T14109 T14102 prep as,shares
R4132 T14110 T14111 det the,strain
R4133 T14111 T14109 pobj strain,as
R4134 T14112 T14111 compound C3H,strain
R4135 T14113 T14111 acl used,strain
R4136 T14114 T14113 prep in,used
R4137 T14115 T14116 det this,study
R4138 T14116 T14114 pobj study,in
R4139 T14117 T14077 punct ),reported
R4140 T14118 T14077 punct .,reported
R4141 T14120 T14121 advmod Interestingly,seen
R4142 T14122 T14121 punct ", ",seen
R4143 T14123 T14124 amod significant,heritability
R4144 T14124 T14121 nsubjpass heritability,seen
R4145 T14125 T14124 cc and,heritability
R4146 T14126 T14127 amod genetic,regulation
R4147 T14127 T14124 conj regulation,heritability
R4148 T14128 T14121 auxpass was,seen
R4149 T14129 T14121 prep in,seen
R4150 T14130 T14131 det this,population
R4151 T14131 T14129 pobj population,in
R4152 T14132 T14131 compound F2,population
R4153 T14133 T14121 prep despite,seen
R4154 T14134 T14135 det the,background
R4155 T14135 T14133 pobj background,despite
R4156 T14136 T14135 amod hyperlipidemic,background
R4157 T14137 T14135 punct ", ",background
R4158 T14138 T14135 amod proinflammatory,background
R4159 T14139 T14135 nmod ApoE,background
R4160 T14140 T14139 punct −,ApoE
R4161 T14141 T14139 punct /,ApoE
R4162 T14142 T14139 punct −,ApoE
R4163 T14143 T14135 cc and,background
R4164 T14144 T14145 det the,diet
R4165 T14145 T14135 conj diet,background
R4166 T14146 T14147 amod high,fat
R4167 T14147 T14145 compound fat,diet
R4168 T14148 T14147 punct -,fat
R4169 T14149 T14145 compound Western,diet
R4170 T14150 T14121 punct .,seen
R4171 T14152 T14153 det This,background
R4172 T14153 T14154 nsubj background,possesses
R4173 T14155 T14156 amod several,advantages
R4174 T14156 T14154 dobj advantages,possesses
R4175 T14157 T14156 punct ", ",advantages
R4176 T14158 T14159 amod such,as
R4177 T14159 T14156 prep as,advantages
R4178 T14160 T14159 pcomp allowing,as
R4179 T14161 T14162 det the,modeling
R4180 T14162 T14160 dobj modeling,allowing
R4181 T14163 T14162 prep of,modeling
R4182 T14164 T14165 amod human,like
R4183 T14165 T14167 amod like,states
R4184 T14166 T14165 punct -,like
R4185 T14167 T14163 pobj states,of
R4186 T14168 T14167 compound disease,states
R4187 T14169 T14154 punct .,possesses
R4188 T14171 T14172 det The,effects
R4189 T14172 T14177 nsubj effects,reflect
R4190 T14173 T14174 advmod predominantly,driven
R4191 T14174 T14172 amod driven,effects
R4192 T14175 T14174 amod female,driven
R4193 T14176 T14174 punct -,driven
R4194 T14178 T14172 prep of,effects
R4195 T14179 T14180 det the,cQTLs
R4196 T14180 T14178 pobj cQTLs,of
R4197 T14181 T14180 nummod five,cQTLs
R4198 T14182 T14177 advmod likely,reflect
R4199 T14183 T14184 det the,effect
R4200 T14184 T14177 dobj effect,reflect
R4201 T14185 T14184 amod significant,effect
R4202 T14186 T14184 prep of,effect
R4203 T14187 T14188 amod differential,secretions
R4204 T14188 T14186 pobj secretions,of
R4205 T14189 T14188 amod gonadal,secretions
R4206 T14190 T14188 compound hormone,secretions
R4207 T14191 T14184 prep on,effect
R4208 T14192 T14193 det the,regulation
R4209 T14193 T14191 pobj regulation,on
R4210 T14194 T14193 amod genetic,regulation
R4211 T14195 T14193 prep of,regulation
R4212 T14196 T14197 det this,trait
R4213 T14197 T14195 pobj trait,of
R4214 T14198 T14197 amod complex,trait
R4215 T14199 T14177 punct .,reflect
R4216 T14201 T14202 det The,identification
R4217 T14202 T14203 nsubj identification,remains
R4218 T14204 T14202 prep of,identification
R4219 T14205 T14204 pobj genes,of
R4220 T14206 T14205 acl underlying,genes
R4221 T14207 T14206 dobj cQTLs,underlying
R4222 T14208 T14209 det a,challenge
R4223 T14209 T14203 attr challenge,remains
R4224 T14210 T14203 punct .,remains
R4225 T14212 T14213 det The,availability
R4226 T14213 T14215 nsubj availability,begun
R4227 T14214 T14213 amod widespread,availability
R4228 T14216 T14213 prep of,availability
R4229 T14217 T14218 npadvmod genome,wide
R4230 T14218 T14220 amod wide,analysis
R4231 T14219 T14218 punct -,wide
R4232 T14220 T14216 pobj analysis,of
R4233 T14221 T14220 compound expression,analysis
R4234 T14222 T14215 aux has,begun
R4235 T14223 T14224 aux to,address
R4236 T14224 T14215 xcomp address,begun
R4237 T14225 T14224 dobj this,address
R4238 T14226 T14224 prep by,address
R4239 T14227 T14226 pcomp providing,by
R4240 T14228 T14229 det a,snapshot
R4241 T14229 T14227 dobj snapshot,providing
R4242 T14230 T14229 prep of,snapshot
R4243 T14231 T14230 pobj transcription,of
R4244 T14232 T14231 prep in,transcription
R4245 T14233 T14234 amod relevant,organs
R4246 T14234 T14232 pobj organs,in
R4247 T14235 T14227 cc and,providing
R4248 T14236 T14237 advmod thus,providing
R4249 T14237 T14227 conj providing,providing
R4250 T14238 T14239 amod initial,information
R4251 T14239 T14237 dobj information,providing
R4252 T14240 T14239 prep for,information
R4253 T14241 T14242 det which,genes
R4254 T14242 T14243 dep genes,differentiate
R4255 T14243 T14240 pcomp differentiate,for
R4256 T14244 T14243 aux can,differentiate
R4257 T14245 T14246 det a,trait
R4258 T14246 T14243 dobj trait,differentiate
R4259 T14247 T14246 amod given,trait
R4260 T14248 T14215 punct .,begun
R4261 T14250 T14251 advmod Furthermore,map
R4262 T14252 T14251 punct ", ",map
R4263 T14253 T14251 prep by,map
R4264 T14254 T14253 pcomp treating,by
R4265 T14255 T14256 compound transcript,levels
R4266 T14256 T14254 dobj levels,treating
R4267 T14257 T14254 prep as,treating
R4268 T14258 T14259 amod quantitative,traits
R4269 T14259 T14257 pobj traits,as
R4270 T14260 T14251 punct ", ",map
R4271 T14261 T14251 nsubj we,map
R4272 T14262 T14251 aux can,map
R4273 T14263 T14264 det the,regulation
R4274 T14264 T14251 dobj regulation,map
R4275 T14265 T14264 amod genetic,regulation
R4276 T14266 T14264 acl underlying,regulation
R4277 T14267 T14268 amod differential,expression
R4278 T14268 T14266 dobj expression,underlying
R4279 T14269 T14268 compound gene,expression
R4280 T14270 T14271 punct (,eQTLs
R4281 T14271 T14251 parataxis eQTLs,map
R4282 T14272 T14271 punct ),eQTLs
R4283 T14273 T14251 punct .,map
R4284 T14275 T14276 det Those,eQTLs
R4285 T14276 T14277 nsubj eQTLs,are
R4286 T14278 T14279 dep that,have
R4287 T14279 T14276 relcl have,eQTLs
R4288 T14280 T14281 npadvmod cis,acting
R4289 T14281 T14283 amod acting,variations
R4290 T14282 T14281 punct -,acting
R4291 T14283 T14279 dobj variations,have
R4292 T14284 T14283 acl affecting,variations
R4293 T14285 T14286 poss their,transcription
R4294 T14286 T14284 dobj transcription,affecting
R4295 T14287 T14288 amod potential,genes
R4296 T14288 T14277 attr genes,are
R4297 T14289 T14288 compound candidate,genes
R4298 T14290 T14288 prep for,genes
R4299 T14291 T14292 det the,trait
R4300 T14292 T14290 pobj trait,for
R4301 T14293 T14277 punct .,are
R4302 T14295 T14296 prep At,detected
R4303 T14297 T14298 det a,level
R4304 T14298 T14295 pobj level,At
R4305 T14299 T14300 amod single,trait
R4306 T14300 T14298 nmod trait,level
R4307 T14301 T14298 punct ", ",level
R4308 T14302 T14303 npadvmod genome,wide
R4309 T14303 T14298 amod wide,level
R4310 T14304 T14303 punct -,wide
R4311 T14305 T14298 compound significance,level
R4312 T14306 T14298 prep of,level
R4313 T14307 T14306 pobj 0.05,of
R4314 T14308 T14296 punct ", ",detected
R4315 T14309 T14296 nsubj we,detected
R4316 T14310 T14311 nummod "6,676",eQTLs
R4317 T14311 T14296 dobj eQTLs,detected
R4318 T14312 T14311 acl representing,eQTLs
R4319 T14313 T14314 nummod "4,998",genes
R4320 T14314 T14312 dobj genes,representing
R4321 T14315 T14314 punct ", ",genes
R4322 T14316 T14317 prep of,were
R4323 T14317 T14314 relcl were,genes
R4324 T14318 T14316 pobj which,of
R4325 T14319 T14317 nsubj "2,118",were
R4326 T14320 T14321 npadvmod cis,acting
R4327 T14321 T14317 acomp acting,were
R4328 T14322 T14321 punct -,acting
R4329 T14323 T14296 punct .,detected
R4330 T14325 T14326 prep At,increased
R4331 T14327 T14328 amod increased,thresholds
R4332 T14328 T14325 pobj thresholds,At
R4333 T14329 T14326 punct ", ",increased
R4334 T14330 T14331 det the,proportion
R4335 T14331 T14326 nsubj proportion,increased
R4336 T14332 T14331 prep of,proportion
R4337 T14333 T14334 compound cis,eQTLs
R4338 T14334 T14332 pobj eQTLs,of
R4339 T14335 T14334 punct -,eQTLs
R4340 T14336 T14326 punct ", ",increased
R4341 T14337 T14338 dep which,is
R4342 T14338 T14326 ccomp is,increased
R4343 T14339 T14338 prep in,is
R4344 T14340 T14341 amod good,agreement
R4345 T14341 T14339 pobj agreement,in
R4346 T14342 T14341 prep with,agreement
R4347 T14343 T14344 amod previous,studies
R4348 T14344 T14342 pobj studies,with
R4349 T14345 T14346 punct [,15
R4350 T14346 T14338 parataxis 15,is
R4351 T14347 T14346 nummod 5,15
R4352 T14348 T14346 punct ",",15
R4353 T14349 T14346 punct ],15
R4354 T14350 T14338 cc and,is
R4355 T14351 T14352 advmod likely,reflects
R4356 T14352 T14338 conj reflects,is
R4357 T14353 T14354 det the,power
R4358 T14354 T14352 dobj power,reflects
R4359 T14355 T14354 amod increased,power
R4360 T14356 T14357 aux to,detect
R4361 T14357 T14354 acl detect,power
R4362 T14358 T14359 npadvmod cis,acting
R4363 T14359 T14361 amod acting,variations
R4364 T14360 T14359 punct -,acting
R4365 T14361 T14357 dobj variations,detect
R4366 T14362 T14361 acl affecting,variations
R4367 T14363 T14362 dobj transcription,affecting
R4368 T14364 T14326 punct .,increased
R4369 T14366 T14367 prep Of,possessed
R4370 T14368 T14369 det all,eQTLs
R4371 T14369 T14366 pobj eQTLs,Of
R4372 T14370 T14369 nummod "6,676",eQTLs
R4373 T14371 T14369 amod significant,eQTLs
R4374 T14372 T14367 punct ", ",possessed
R4375 T14373 T14367 nsubj "1,166",possessed
R4376 T14374 T14375 amod significant,interactions
R4377 T14375 T14367 dobj interactions,possessed
R4378 T14376 T14375 compound sex,interactions
R4379 T14377 T14367 punct .,possessed
R4380 T14379 T14380 prep Of,were
R4381 T14381 T14379 pobj these,Of
R4382 T14382 T14380 punct ", ",were
R4383 T14383 T14380 nsubj 304,were
R4384 T14384 T14380 attr cis,were
R4385 T14385 T14380 cc and,were
R4386 T14386 T14387 nsubj 852,were
R4387 T14387 T14380 conj were,were
R4388 T14388 T14387 attr trans,were
R4389 T14389 T14387 punct ", ",were
R4390 T14390 T14387 conj suggesting,were
R4391 T14391 T14392 mark that,occur
R4392 T14392 T14390 ccomp occur,suggesting
R4393 T14393 T14394 advmod only,minority
R4394 T14394 T14392 nsubj minority,occur
R4395 T14395 T14394 det a,minority
R4396 T14396 T14394 prep of,minority
R4397 T14397 T14398 det the,effects
R4398 T14398 T14396 pobj effects,of
R4399 T14399 T14400 npadvmod sex,specific
R4400 T14400 T14398 amod specific,effects
R4401 T14401 T14400 punct -,specific
R4402 T14402 T14398 prep on,effects
R4403 T14403 T14404 det the,regulation
R4404 T14404 T14402 pobj regulation,on
R4405 T14405 T14404 prep of,regulation
R4406 T14406 T14407 compound gene,expression
R4407 T14407 T14405 pobj expression,of
R4408 T14408 T14392 prep through,occur
R4409 T14409 T14408 pobj polymorphisms,through
R4410 T14410 T14409 prep within,polymorphisms
R4411 T14411 T14412 det the,gene
R4412 T14412 T14410 pobj gene,within
R4413 T14413 T14412 appos itself,gene
R4414 T14414 T14380 punct .,were
R4415 T14416 T14417 advmod Rather,is
R4416 T14418 T14417 punct ", ",is
R4417 T14419 T14420 amod underlying,regulation
R4418 T14420 T14417 nsubj regulation,is
R4419 T14421 T14420 amod genetic,regulation
R4420 T14422 T14420 prep of,regulation
R4421 T14423 T14424 amod most,transcripts
R4422 T14424 T14422 pobj transcripts,of
R4423 T14425 T14426 det the,result
R4424 T14426 T14417 attr result,is
R4425 T14427 T14426 prep of,result
R4426 T14428 T14427 pobj interactions,of
R4427 T14429 T14428 prep between,interactions
R4428 T14430 T14431 compound trans,loci
R4429 T14431 T14429 pobj loci,between
R4430 T14432 T14431 cc and,loci
R4431 T14433 T14434 npadvmod sex,specific
R4432 T14434 T14436 amod specific,factors
R4433 T14435 T14434 punct -,specific
R4434 T14436 T14431 conj factors,loci
R4435 T14437 T14436 punct (,factors
R4436 T14438 T14439 advmod e.g.,hormones
R4437 T14439 T14436 appos hormones,factors
R4438 T14440 T14439 punct ", ",hormones
R4439 T14441 T14417 punct ),is
R4440 T14442 T14417 punct .,is
R4441 T14444 T14445 prep As,is
R4442 T14446 T14444 prep with,As
R4443 T14447 T14446 pobj cQTLs,with
R4444 T14448 T14445 punct ", ",is
R4445 T14449 T14450 compound sex,bias
R4446 T14450 T14445 nsubj bias,is
R4447 T14451 T14450 prep in,bias
R4448 T14452 T14453 det the,regulation
R4449 T14453 T14451 pobj regulation,in
R4450 T14454 T14455 advmod predominantly,trans
R4451 T14455 T14453 amod trans,regulation
R4452 T14456 T14453 amod genetic,regulation
R4453 T14457 T14453 prep of,regulation
R4454 T14458 T14459 compound gene,expression
R4455 T14459 T14457 pobj expression,of
R4456 T14460 T14445 advmod likely,is
R4457 T14461 T14445 acomp secondary,is
R4458 T14462 T14461 prep to,secondary
R4459 T14463 T14464 amod different,profiles
R4460 T14464 T14462 pobj profiles,to
R4461 T14465 T14466 compound sex,hormone
R4462 T14466 T14464 compound hormone,profiles
R4463 T14467 T14445 punct .,is
R4464 T14469 T14470 advmod Recently,demonstrated
R4465 T14471 T14470 punct ", ",demonstrated
R4466 T14472 T14470 advcl using,demonstrated
R4467 T14473 T14474 det a,dataset
R4468 T14474 T14472 dobj dataset,using
R4469 T14475 T14474 amod similar,dataset
R4470 T14476 T14470 punct ", ",demonstrated
R4471 T14477 T14478 poss our,group
R4472 T14478 T14470 nsubj group,demonstrated
R4473 T14479 T14480 mark that,represent
R4474 T14480 T14470 ccomp represent,demonstrated
R4475 T14481 T14482 amod significant,eQTLs
R4476 T14482 T14480 nsubj eQTLs,represent
R4477 T14483 T14482 compound cis,eQTLs
R4478 T14484 T14482 punct -,eQTLs
R4479 T14485 T14486 punct (,5
R4480 T14486 T14482 parataxis 5,eQTLs
R4481 T14487 T14486 nsubj p,5
R4482 T14488 T14486 punct <,5
R4483 T14489 T14486 punct ×,5
R4484 T14490 T14491 nummod 10,5
R4485 T14491 T14486 appos 5,5
R4486 T14492 T14491 punct −,5
R4487 T14493 T14486 punct ),5
R4488 T14494 T14480 advmod largely,represent
R4489 T14495 T14496 amod true,positives
R4490 T14496 T14480 dobj positives,represent
R4491 T14497 T14498 punct [,30
R4492 T14498 T14480 parataxis 30,represent
R4493 T14499 T14498 punct ],30
R4494 T14500 T14480 cc and,represent
R4495 T14501 T14480 conj are,represent
R4496 T14502 T14501 acomp enriched,are
R4497 T14503 T14501 prep for,are
R4498 T14504 T14505 advmod highly,polymorphic
R4499 T14505 T14506 amod polymorphic,regions
R4500 T14506 T14503 pobj regions,for
R4501 T14507 T14506 prep over,regions
R4502 T14508 T14509 det the,genome
R4503 T14509 T14507 pobj genome,over
R4504 T14510 T14509 compound mouse,genome
R4505 T14511 T14470 punct .,demonstrated
R4506 T14513 T14514 det The,eQTLs
R4507 T14514 T14517 nsubj eQTLs,overlap
R4508 T14515 T14514 compound cis,eQTLs
R4509 T14516 T14514 punct -,eQTLs
R4510 T14518 T14514 acl presented,eQTLs
R4511 T14519 T14518 prep in,presented
R4512 T14520 T14519 pobj Table,in
R4513 T14521 T14520 nummod 5,Table
R4514 T14522 T14517 prep with,overlap
R4515 T14523 T14522 pobj one,with
R4516 T14524 T14523 prep of,one
R4517 T14525 T14526 det the,cQTLs
R4518 T14526 T14524 pobj cQTLs,of
R4519 T14527 T14528 amod gonadal,mass
R4520 T14528 T14526 compound mass,cQTLs
R4521 T14529 T14528 compound fat,mass
R4522 T14530 T14517 cc and,overlap
R4523 T14531 T14532 aux should,considered
R4524 T14532 T14517 conj considered,overlap
R4525 T14533 T14532 auxpass be,considered
R4526 T14534 T14535 amod potential,candidates
R4527 T14535 T14532 oprd candidates,considered
R4528 T14536 T14517 punct .,overlap
R4529 T14538 T14539 prep Given,reasoned
R4530 T14540 T14541 det the,effects
R4531 T14541 T14538 pobj effects,Given
R4532 T14542 T14541 compound sex,effects
R4533 T14543 T14541 prep in,effects
R4534 T14544 T14545 det the,cQTLs
R4535 T14545 T14543 pobj cQTLs,in
R4536 T14546 T14547 amod gonadal,mass
R4537 T14547 T14545 compound mass,cQTLs
R4538 T14548 T14547 compound fat,mass
R4539 T14549 T14539 punct ", ",reasoned
R4540 T14550 T14539 nsubj we,reasoned
R4541 T14551 T14552 mark that,receive
R4542 T14552 T14539 ccomp receive,reasoned
R4543 T14553 T14554 det the,eQTLs
R4544 T14554 T14552 nsubj eQTLs,receive
R4545 T14555 T14554 compound cis,eQTLs
R4546 T14556 T14554 punct -,eQTLs
R4547 T14557 T14554 prep with,eQTLs
R4548 T14558 T14559 amod significant,effects
R4549 T14559 T14557 pobj effects,with
R4550 T14560 T14561 npadvmod sex,additive
R4551 T14561 T14559 amod additive,effects
R4552 T14562 T14561 punct *,additive
R4553 T14563 T14561 cc and,additive
R4554 T14564 T14565 npadvmod sex,dominant
R4555 T14565 T14561 conj dominant,additive
R4556 T14566 T14565 punct *,dominant
R4557 T14567 T14552 aux should,receive
R4558 T14568 T14569 compound priority,consideration
R4559 T14569 T14552 dobj consideration,receive
R4560 T14570 T14539 punct .,reasoned
R4561 T14572 T14573 det The,use
R4562 T14573 T14574 nsubj use,is
R4563 T14575 T14573 prep of,use
R4564 T14576 T14575 pobj eQTLs,of
R4565 T14577 T14578 aux to,dissect
R4566 T14578 T14573 acl dissect,use
R4567 T14579 T14578 dobj cQTLs,dissect
R4568 T14580 T14581 det a,method
R4569 T14581 T14574 attr method,is
R4570 T14582 T14583 advmod still,in
R4571 T14583 T14581 prep in,method
R4572 T14584 T14585 poss its,infancy
R4573 T14585 T14583 pobj infancy,in
R4574 T14586 T14581 punct ", ",method
R4575 T14587 T14581 prep with,method
R4576 T14588 T14589 amod uncertain,efficacy
R4577 T14589 T14587 pobj efficacy,with
R4578 T14590 T14589 cc and,efficacy
R4579 T14591 T14589 conj applicability,efficacy
R4580 T14592 T14574 punct .,is
R4581 T14594 T14595 advmod Nevertheless,provides
R4582 T14596 T14595 punct ", ",provides
R4583 T14597 T14595 nsubj application,provides
R4584 T14598 T14597 prep of,application
R4585 T14599 T14600 det this,analysis
R4586 T14600 T14598 pobj analysis,of
R4587 T14601 T14597 prep to,application
R4588 T14602 T14603 det this,dataset
R4589 T14603 T14601 pobj dataset,to
R4590 T14604 T14605 det some,genes
R4591 T14605 T14595 dobj genes,provides
R4592 T14606 T14607 advmod tantalizingly,attractive
R4593 T14607 T14605 amod attractive,genes
R4594 T14608 T14605 compound candidate,genes
R4595 T14609 T14595 punct .,provides
R4596 T14611 T14612 nummod One,shortcoming
R4597 T14612 T14613 nsubj shortcoming,is
R4598 T14614 T14612 prep of,shortcoming
R4599 T14615 T14616 det this,approach
R4600 T14616 T14614 pobj approach,of
R4601 T14617 T14613 punct ", ",is
R4602 T14618 T14613 advmod however,is
R4603 T14619 T14613 punct ", ",is
R4604 T14620 T14621 mark that,limited
R4605 T14621 T14613 ccomp limited,is
R4606 T14622 T14623 compound candidate,genes
R4607 T14623 T14621 nsubjpass genes,limited
R4608 T14624 T14621 auxpass are,limited
R4609 T14625 T14621 prep to,limited
R4610 T14626 T14625 pobj those,to
R4611 T14627 T14628 poss whose,levels
R4612 T14628 T14631 dep levels,vary
R4613 T14629 T14630 compound transcript,expression
R4614 T14630 T14628 compound expression,levels
R4615 T14631 T14626 relcl vary,those
R4616 T14632 T14631 prep in,vary
R4617 T14633 T14632 pobj association,in
R4618 T14634 T14633 prep with,association
R4619 T14635 T14636 det a,polymorphism
R4620 T14636 T14634 pobj polymorphism,with
R4621 T14637 T14636 amod nearby,polymorphism
R4622 T14638 T14639 dep that,differs
R4623 T14745 T14746 mark if,is
R4624 T14746 T14740 advcl is,detecting
R4625 T14747 T14748 det the,tissue
R4626 T14748 T14746 nsubj tissue,is
R4627 T14749 T14748 acl arrayed,tissue
R4628 T14750 T14746 neg not,is
R4629 T14751 T14752 det the,tissue
R4630 T14752 T14746 attr tissue,is
R4631 T14753 T14754 advmod where,exerted
R4632 T14639 T14636 relcl differs,polymorphism
R4633 T14754 T14752 relcl exerted,tissue
R4634 T14755 T14756 det the,control
R4635 T14756 T14754 nsubjpass control,exerted
R4636 T14640 T14639 prep between,differs
R4637 T14757 T14754 auxpass is,exerted
R4638 T14641 T14642 det the,strains
R4639 T14642 T14640 pobj strains,between
R4640 T14643 T14642 amod parental,strains
R4641 T14758 T14728 punct .,is
R4642 T14644 T14626 punct —,those
R4643 T14645 T14646 prep in,genes
R4644 T14760 T14761 nsubj This,is
R4645 T14646 T14626 appos genes,those
R4646 T14647 T14648 amod other,words
R4647 T14648 T14645 pobj words,in
R4648 T14649 T14646 punct ", ",genes
R4649 T14650 T14646 prep with,genes
R4650 T14762 T14763 advmod particularly,relevant
R4651 T14651 T14652 amod significant,eQTLs
R4652 T14652 T14650 pobj eQTLs,with
R4653 T14653 T14651 cc and,significant
R4654 T14654 T14651 conj detectable,significant
R4655 T14763 T14761 acomp relevant,is
R4656 T14655 T14652 compound cis,eQTLs
R4657 T14656 T14652 punct -,eQTLs
R4658 T14657 T14613 punct .,is
R4659 T14764 T14763 prep for,relevant
R4660 T14659 T14660 advmod However,is
R4661 T14765 T14766 det a,trait
R4662 T14660 T14663 ccomp is,affect
R4663 T14661 T14660 punct ", ",is
R4664 T14766 T14764 pobj trait,for
R4665 T14662 T14660 nsubj it,is
R4666 T14664 T14660 neg not,is
R4667 T14767 T14768 amod such,as
R4668 T14665 T14666 advmod strictly,necessary
R4669 T14666 T14660 acomp necessary,is
R4670 T14667 T14668 mark for,have
R4671 T14768 T14766 prep as,trait
R4672 T14668 T14660 advcl have,is
R4673 T14669 T14670 compound candidate,genes
R4674 T14670 T14668 nsubj genes,have
R4675 T14769 T14770 compound adipose,mass
R4676 T14671 T14668 aux to,have
R4677 T14672 T14668 dobj evidence,have
R4678 T14673 T14672 prep of,evidence
R4679 T14770 T14768 pobj mass,as
R4680 T14674 T14675 amod such,linkage
R4681 T14675 T14673 pobj linkage,of
R4682 T14676 T14663 punct : ,affect
R4683 T14771 T14770 compound tissue,mass
R4684 T14677 T14663 nsubj polymorphisms,affect
R4685 T14678 T14677 acl underlying,polymorphisms
R4686 T14679 T14680 det a,cQTL
R4687 T14772 T14770 punct ", ",mass
R4688 T14680 T14678 dobj cQTL,underlying
R4689 T14681 T14680 compound trait,cQTL
R4690 T14773 T14774 dep which,controlled
R4691 T14774 T14770 relcl controlled,mass
R4692 T14682 T14663 aux can,affect
R4693 T14775 T14774 auxpass is,controlled
R4694 T14683 T14684 compound gene,function
R4695 T14684 T14663 dobj function,affect
R4696 T14776 T14774 agent by,controlled
R4697 T14685 T14684 cc or,function
R4698 T14686 T14687 amod posttranslational,modifications
R4699 T14687 T14684 conj modifications,function
R4700 T14688 T14663 punct .,affect
R4701 T14777 T14778 amod multiple,tissues
R4702 T14690 T14691 advmod Nevertheless,known
R4703 T14692 T14691 punct ", ",known
R4704 T14778 T14776 pobj tissues,by
R4705 T14693 T14694 amod several,phenotypes
R4706 T14694 T14691 nsubjpass phenotypes,known
R4707 T14695 T14691 auxpass are,known
R4708 T14779 T14761 punct .,is
R4709 T14696 T14697 aux to,regulated
R4710 T14697 T14691 xcomp regulated,known
R4711 T14781 T14782 nsubj We,propose
R4712 T14698 T14697 auxpass be,regulated
R4713 T14699 T14697 punct ", ",regulated
R4714 T14700 T14701 advmod at,least
R4715 T14701 T14702 advmod least,partly
R4716 T14783 T14784 mark that,provide
R4717 T14702 T14703 advmod partly,at
R4718 T14703 T14697 prep at,regulated
R4719 T14704 T14703 punct ", ",at
R4720 T14705 T14706 det the,level
R4721 T14784 T14782 ccomp provide,propose
R4722 T14706 T14703 pobj level,at
R4723 T14707 T14706 prep of,level
R4724 T14708 T14707 pobj transcription,of
R4725 T14785 T14784 nsubj analysis,provide
R4726 T14709 T14708 cc or,transcription
R4727 T14710 T14711 compound mRNA,stability
R4728 T14711 T14708 conj stability,transcription
R4729 T14786 T14785 prep of,analysis
R4730 T14712 T14697 punct ", ",regulated
R4731 T14713 T14714 dep which,is
R4732 T14787 T14788 amod correlated,genes
R4733 T14714 T14697 ccomp is,regulated
R4734 T14715 T14716 advmod exactly,what
R4735 T14716 T14717 dep what,designed
R4736 T14788 T14786 pobj genes,of
R4737 T14717 T14714 ccomp designed,is
R4738 T14718 T14719 poss our,methods
R4739 T14719 T14717 nsubjpass methods,designed
R4740 T14789 T14784 aux can,provide
R4741 T14720 T14717 auxpass are,designed
R4742 T14721 T14722 aux to,detect
R4743 T14722 T14717 xcomp detect,designed
R4744 T14790 T14784 dobj guidance,provide
R4745 T14723 T14691 punct .,known
R4746 T14791 T14792 mark as,discussed
R4747 T14725 T14726 det A,problem
R4748 T14792 T14784 advcl discussed,provide
R4749 T14726 T14728 nsubj problem,is
R4750 T14727 T14726 amod separate,problem
R4751 T14729 T14730 mark that,preclude
R4752 T14793 T14792 advmod below,discussed
R4753 T14730 T14728 ccomp preclude,is
R4754 T14731 T14732 npadvmod organ,specific
R4755 T14732 T14734 amod specific,differences
R4756 T14794 T14782 punct .,propose
R4757 T14733 T14732 punct -,specific
R4758 T14734 T14730 nsubj differences,preclude
R4759 T14735 T14736 compound gene,expression
R4760 T14736 T14734 compound expression,differences
R4761 T14737 T14730 aux may,preclude
R4762 T14738 T14730 dobj one,preclude
R4763 T14739 T14730 prep from,preclude
R4764 T14740 T14739 pcomp detecting,from
R4765 T14741 T14742 det the,gene
R4766 T14742 T14740 dobj gene,detecting
R4767 T14743 T14742 amod relevant,gene
R4768 T14744 T14742 amod causative,gene