> top > docs > PMC:1359071 > spans > 1-1286 > annotations

PMC:1359071 / 1-1286 JSONTXT

Annnotations TAB JSON ListView MergeView

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T473 11-18 SO:0001026 denotes Genomic
T474 172-182 GO:0010467 denotes expression
T475 254-259 SO:0000704 denotes genes
T476 320-330 GO:0065007 denotes regulation
T477 391-400 SO:0000704 denotes genetical
T478 401-408 SO:0001026 denotes genomic
T479 584-589 NCBITaxon:10088 denotes mouse
T480 625-639 CHEBI:39015 denotes apolipoprotein
T481 625-641 PR:000004155 denotes apolipoprotein E
T482 648-652 PR:000004155 denotes ApoE
T483 678-682 PR:000004155 denotes ApoE
T484 720-729 GO:0008152 denotes metabolic
T485 778-785 NCBITaxon:33208 denotes animals
T486 901-906 UBERON:0002107 denotes liver
T487 907-911 SO:0000704 denotes gene
T488 907-922 GO:0010467 denotes gene expression
T489 923-946 SO:0000771 denotes quantitative trait loci
T490 1048-1055 UBERON:0000991 denotes gonadal
T491 1100-1110 GO:0065007 denotes regulation
T492 1205-1234 GO:0010468 denotes regulation of gene expression
T493 1219-1223 SO:0000704 denotes gene

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T498 11-18 SO_EXT:0001026 denotes Genomic
T499 33-36 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes Fat
T500 172-182 GO:0010467 denotes expression
T501 254-259 SO_EXT:0000704 denotes genes
T502 320-330 GO:0065007 denotes regulation
T503 339-352 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T504 391-400 SO_EXT:0000704 denotes genetical
T505 401-408 SO_EXT:0001026 denotes genomic
T506 584-589 NCBITaxon:10088 denotes mouse
T507 625-639 CHEBI:39015 denotes apolipoprotein
T508 625-641 PR_EXT:000004155 denotes apolipoprotein E
T509 642-646 SO_EXT:sequence_nullness denotes null
T510 648-652 PR_EXT:000004155 denotes ApoE
T511 652-653 SO_EXT:sequence_nullness_or_absence denotes −
T512 654-655 SO_EXT:sequence_nullness_or_absence denotes −
T513 678-682 PR_EXT:000004155 denotes ApoE
T514 682-683 SO_EXT:sequence_nullness_or_absence denotes −
T515 684-685 SO_EXT:sequence_nullness_or_absence denotes −
T516 720-729 GO:0008152 denotes metabolic
T517 778-785 NCBITaxon:33208 denotes animals
T518 901-906 UBERON:0002107 denotes liver
T519 907-911 SO_EXT:0000704 denotes gene
T520 907-922 GO:0010467 denotes gene expression
T521 923-946 SO_EXT:0000771 denotes quantitative trait loci
T522 1036-1044 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes genetics
T523 1048-1055 UBERON:0000991 denotes gonadal
T524 1056-1059 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T525 1100-1110 GO:0065007 denotes regulation
T526 1205-1234 GO:0010468 denotes regulation of gene expression
T527 1219-1223 SO_EXT:0000704 denotes gene

craft-sa-dev

Id Subject Object Predicate Lexical cue
T535 19-27 NN denotes Analysis
T537 7-10 CC denotes and
T538 11-18 JJ denotes Genomic
T539 73-80 VBZ denotes Reveals
T540 28-30 IN denotes of
T541 31-32 DT denotes a
T542 42-47 NN denotes Trait
T543 33-36 NN denotes Fat
T544 37-41 NN denotes Mass
T545 48-52 IN denotes with
T546 53-60 JJ denotes Complex
T547 61-72 NN denotes Inheritance
T548 81-87 JJ denotes Marked
T549 92-103 NN denotes Specificity
T550 88-91 NN denotes Sex
T551 103-104 sentence denotes
T552 153-290 sentence denotes The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes.
T553 153-156 DT denotes The
T554 157-168 NN denotes integration
T555 237-241 VBN denotes used
T556 169-171 IN denotes of
T557 172-182 NN denotes expression
T558 183-192 NN denotes profiling
T559 193-197 IN denotes with
T560 198-205 NN denotes linkage
T561 206-214 NN denotes analysis
T562 215-218 VBZ denotes has
T563 219-231 RB denotes increasingly
T564 232-236 VBN denotes been
T565 242-244 TO denotes to
T566 245-253 VB denotes identify
T567 254-259 NNS denotes genes
T568 260-270 VBG denotes underlying
T569 271-278 JJ denotes complex
T570 279-289 NNS denotes phenotypes
T571 289-290 . denotes .
T572 290-500 sentence denotes The effects of gender on the regulation of many physiological traits are well documented; however, “genetical genomic” analyses have not yet addressed the degree to which their conclusions are affected by sex.
T573 291-294 DT denotes The
T574 295-302 NNS denotes effects
T575 360-363 VBP denotes are
T576 303-305 IN denotes of
T577 306-312 NN denotes gender
T578 313-315 IN denotes on
T579 316-319 DT denotes the
T580 320-330 NN denotes regulation
T581 331-333 IN denotes of
T582 334-338 JJ denotes many
T583 353-359 NNS denotes traits
T584 339-352 JJ denotes physiological
T585 432-441 VBN denotes addressed
T586 364-368 RB denotes well
T587 369-379 JJ denotes documented
T588 379-380 : denotes ;
T589 381-388 RB denotes however
T590 388-390 , denotes ,
T591 390-391 `` denotes “
T592 410-418 NNS denotes analyses
T593 391-400 JJ denotes genetical
T594 401-408 JJ denotes genomic
T595 408-409 '' denotes ”
T596 419-423 VBP denotes have
T597 424-427 RB denotes not
T598 428-431 RB denotes yet
T599 442-445 DT denotes the
T600 446-452 NN denotes degree
T601 453-455 IN denotes to
T602 484-492 VBN denotes affected
T603 456-461 WDT denotes which
T604 462-467 PRP$ denotes their
T605 468-479 NNS denotes conclusions
T606 480-483 VBP denotes are
T607 493-495 IN denotes by
T608 496-499 NN denotes sex
T609 499-500 . denotes .
T610 500-668 sentence denotes We constructed and densely genotyped a large F2 intercross derived from the inbred mouse strains C57BL/6J and C3H/HeJ on an apolipoprotein E null (ApoE−/−) background.
T611 501-503 PRP denotes We
T612 504-515 VBD denotes constructed
T613 516-519 CC denotes and
T614 520-527 RB denotes densely
T615 528-537 VBD denotes genotyped
T616 538-539 DT denotes a
T617 549-559 NN denotes intercross
T618 540-545 JJ denotes large
T619 546-548 NN denotes F2
T620 560-567 VBN denotes derived
T621 568-572 IN denotes from
T622 573-576 DT denotes the
T623 590-597 NNS denotes strains
T624 577-583 JJ denotes inbred
T625 584-589 NN denotes mouse
T626 598-603 NN denotes C57BL
T627 604-606 NN denotes 6J
T628 603-604 HYPH denotes /
T629 607-610 CC denotes and
T630 611-614 NN denotes C3H
T631 615-618 NN denotes HeJ
T632 614-615 HYPH denotes /
T633 619-621 IN denotes on
T634 622-624 DT denotes an
T635 657-667 NN denotes background
T636 625-639 NN denotes apolipoprotein
T637 640-641 NN denotes E
T638 642-646 JJ denotes null
T639 647-648 -LRB- denotes (
T640 648-652 NN denotes ApoE
T641 652-653 SYM denotes −
T642 653-654 HYPH denotes /
T643 654-655 SYM denotes −
T644 655-656 -RRB- denotes )
T645 667-668 . denotes .
T646 668-751 sentence denotes This BXH.ApoE−/− population recapitulates several “metabolic syndrome” phenotypes.
T647 669-673 DT denotes This
T648 686-696 NN denotes population
T649 674-682 NN denotes BXH.ApoE
T650 682-683 SYM denotes −
T651 683-684 HYPH denotes /
T652 684-685 SYM denotes −
T653 697-710 VBZ denotes recapitulates
T654 711-718 JJ denotes several
T655 740-750 NNS denotes phenotypes
T656 719-720 `` denotes “
T657 720-729 JJ denotes metabolic
T658 730-738 NN denotes syndrome
T659 738-739 '' denotes ”
T660 750-751 . denotes .
T661 751-871 sentence denotes The cross consists of 334 animals of both sexes, allowing us to specifically test for the dependence of linkage on sex.
T662 752-755 DT denotes The
T663 756-761 NN denotes cross
T664 762-770 VBZ denotes consists
T665 771-773 IN denotes of
T666 774-777 CD denotes 334
T667 778-785 NNS denotes animals
T668 786-788 IN denotes of
T669 789-793 DT denotes both
T670 794-799 NNS denotes sexes
T671 799-801 , denotes ,
T672 801-809 VBG denotes allowing
T673 810-812 PRP denotes us
T674 829-833 VB denotes test
T675 813-815 TO denotes to
T676 816-828 RB denotes specifically
T677 834-837 IN denotes for
T678 838-841 DT denotes the
T679 842-852 NN denotes dependence
T680 853-855 IN denotes of
T681 856-863 NN denotes linkage
T682 864-866 IN denotes on
T683 867-870 NN denotes sex
T684 870-871 . denotes .
T685 871-997 sentence denotes We detected several thousand liver gene expression quantitative trait loci, a significant proportion of which are sex-biased.
T686 872-874 PRP denotes We
T687 875-883 VBD denotes detected
T688 884-891 JJ denotes several
T689 892-900 CD denotes thousand
T690 942-946 NNS denotes loci
T691 901-906 NN denotes liver
T692 907-911 NN denotes gene
T693 912-922 NN denotes expression
T694 923-935 JJ denotes quantitative
T695 936-941 NN denotes trait
T696 946-948 , denotes ,
T697 948-949 DT denotes a
T698 962-972 NN denotes proportion
T699 950-961 JJ denotes significant
T700 982-985 VBP denotes are
T701 973-975 IN denotes of
T702 976-981 WDT denotes which
T703 986-989 NN denotes sex
T704 990-996 VBN denotes biased
T705 989-990 HYPH denotes -
T706 996-997 . denotes .
T707 997-1111 sentence denotes We used these analyses to dissect the genetics of gonadal fat mass, a complex trait with sex-specific regulation.
T708 998-1000 PRP denotes We
T709 1001-1005 VBD denotes used
T710 1006-1011 DT denotes these
T711 1012-1020 NNS denotes analyses
T712 1021-1023 TO denotes to
T713 1024-1031 VB denotes dissect
T714 1032-1035 DT denotes the
T715 1036-1044 NN denotes genetics
T716 1045-1047 IN denotes of
T717 1048-1055 JJ denotes gonadal
T718 1060-1064 NN denotes mass
T719 1056-1059 NN denotes fat
T720 1064-1066 , denotes ,
T721 1066-1067 DT denotes a
T722 1076-1081 NN denotes trait
T723 1068-1075 JJ denotes complex
T724 1082-1086 IN denotes with
T725 1087-1090 NN denotes sex
T726 1091-1099 JJ denotes specific
T727 1090-1091 HYPH denotes -
T728 1100-1110 NN denotes regulation
T729 1110-1111 . denotes .
T730 1111-1235 sentence denotes We present evidence for a remarkably high degree of sex-dependence on both the cis and trans regulation of gene expression.
T731 1112-1114 PRP denotes We
T732 1115-1122 VBP denotes present
T733 1123-1131 NN denotes evidence
T734 1132-1135 IN denotes for
T735 1136-1137 DT denotes a
T736 1154-1160 NN denotes degree
T737 1138-1148 RB denotes remarkably
T738 1149-1153 JJ denotes high
T739 1161-1163 IN denotes of
T740 1164-1167 NN denotes sex
T741 1168-1178 NN denotes dependence
T742 1167-1168 HYPH denotes -
T743 1179-1181 IN denotes on
T744 1182-1186 CC denotes both
T745 1191-1194 NN denotes cis
T746 1187-1190 DT denotes the
T747 1195-1198 CC denotes and
T748 1199-1204 NN denotes trans
T749 1205-1215 NN denotes regulation
T750 1216-1218 IN denotes of
T751 1219-1223 NN denotes gene
T752 1224-1234 NN denotes expression
T753 1234-1235 . denotes .
T755 1236-1238 PRP denotes We
T756 1239-1250 VBP denotes demonstrate
T757 1251-1254 WRB denotes how
T758 1277-1284 VBN denotes applied
T759 1255-1260 DT denotes these
T760 1261-1269 NNS denotes analyses
T761 1270-1273 MD denotes can
T762 1274-1276 VB denotes be
R23 T562 T555 aux has,used
R1 T535 T539 nsubj Analysis,Reveals
R4 T540 T535 prep of,Analysis
R5 T541 T542 det a,Trait
R6 T542 T540 pobj Trait,of
R9 T545 T542 prep with,Trait
R10 T546 T547 amod Complex,Inheritance
R11 T547 T545 pobj Inheritance,with
R12 T548 T549 amod Marked,Specificity
R13 T549 T539 dobj Specificity,Reveals
R15 T553 T554 det The,integration
R16 T554 T555 nsubjpass integration,used
R17 T556 T554 prep of,integration
R18 T557 T558 compound expression,profiling
R19 T558 T556 pobj profiling,of
R20 T559 T554 prep with,integration
R21 T560 T561 compound linkage,analysis
R22 T561 T559 pobj analysis,with
R24 T563 T555 advmod increasingly,used
R25 T564 T555 auxpass been,used
R26 T565 T566 aux to,identify
R27 T566 T555 advcl identify,used
R28 T567 T566 dobj genes,identify
R29 T568 T567 acl underlying,genes
R30 T569 T570 amod complex,phenotypes
R31 T570 T568 dobj phenotypes,underlying
R32 T571 T555 punct .,used
R33 T573 T574 det The,effects
R34 T574 T575 nsubj effects,are
R35 T575 T585 ccomp are,addressed
R43 T583 T581 pobj traits,of
R44 T584 T583 amod physiological,traits
R45 T586 T587 advmod well,documented
R46 T587 T575 acomp documented,are
R47 T588 T585 punct ;,addressed
R48 T589 T585 advmod however,addressed
R49 T590 T585 punct ", ",addressed
R50 T591 T592 punct “,analyses
R51 T592 T585 nsubj analyses,addressed
R55 T596 T585 aux have,addressed
R56 T597 T585 neg not,addressed
R57 T598 T585 advmod yet,addressed
R58 T599 T600 det the,degree
R59 T600 T585 dobj degree,addressed
R60 T601 T602 prep to,affected
R61 T602 T600 relcl affected,degree
R66 T607 T602 agent by,affected
R67 T608 T607 pobj sex,by
R68 T609 T585 punct .,addressed
R69 T611 T612 nsubj We,constructed
R70 T613 T612 cc and,constructed
R71 T614 T615 advmod densely,genotyped
R72 T615 T612 conj genotyped,constructed
R73 T616 T617 det a,intercross
R74 T617 T615 dobj intercross,genotyped
R77 T620 T617 acl derived,intercross
R78 T621 T620 prep from,derived
R79 T622 T623 det the,strains
R80 T623 T621 pobj strains,from
R83 T626 T627 compound C57BL,6J
R84 T627 T623 appos 6J,strains
R86 T629 T627 cc and,6J
R87 T630 T631 compound C3H,HeJ
R88 T631 T627 conj HeJ,6J
R90 T633 T623 prep on,strains
R91 T634 T635 det an,background
R92 T635 T633 pobj background,on
R102 T645 T612 punct .,constructed
R103 T647 T648 det This,population
R104 T648 T653 nsubj population,recapitulates
R109 T654 T655 amod several,phenotypes
R110 T655 T653 dobj phenotypes,recapitulates
R115 T660 T653 punct .,recapitulates
R116 T662 T663 det The,cross
R117 T663 T664 nsubj cross,consists
R118 T665 T664 prep of,consists
R119 T666 T667 nummod 334,animals
R120 T667 T665 pobj animals,of
R121 T668 T667 prep of,animals
R122 T669 T670 det both,sexes
R123 T670 T668 pobj sexes,of
R124 T671 T664 punct ", ",consists
R125 T672 T664 advcl allowing,consists
R126 T673 T674 nsubj us,test
R127 T674 T672 ccomp test,allowing
R130 T677 T674 prep for,test
R131 T678 T679 det the,dependence
R132 T679 T677 pobj dependence,for
R133 T680 T679 prep of,dependence
R134 T681 T680 pobj linkage,of
R135 T682 T679 prep on,dependence
R136 T683 T682 pobj sex,on
R137 T684 T664 punct .,consists
R138 T686 T687 nsubj We,detected
R139 T688 T689 amod several,thousand
R140 T689 T690 nummod thousand,loci
R141 T690 T687 dobj loci,detected
R147 T696 T690 punct ", ",loci
R148 T697 T698 det a,proportion
R149 T698 T700 dep proportion,are
R151 T700 T690 relcl are,loci
R154 T703 T704 npadvmod sex,biased
R155 T704 T700 acomp biased,are
R157 T706 T687 punct .,detected
R158 T708 T709 nsubj We,used
R159 T710 T711 det these,analyses
R160 T711 T709 dobj analyses,used
R161 T712 T713 aux to,dissect
R162 T713 T709 advcl dissect,used
R163 T714 T715 det the,genetics
R164 T715 T713 dobj genetics,dissect
R165 T716 T715 prep of,genetics
R166 T717 T718 amod gonadal,mass
R167 T718 T716 pobj mass,of
R169 T720 T718 punct ", ",mass
R170 T721 T722 det a,trait
R171 T722 T718 appos trait,mass
R173 T724 T722 prep with,trait
R174 T725 T726 npadvmod sex,specific
R175 T726 T728 amod specific,regulation
R177 T728 T724 pobj regulation,with
R178 T729 T709 punct .,used
R179 T731 T732 nsubj We,present
R180 T733 T732 dobj evidence,present
R181 T734 T733 prep for,evidence
R182 T735 T736 det a,degree
R183 T736 T734 pobj degree,for
R186 T739 T736 prep of,degree
R187 T740 T741 compound sex,dependence
R188 T741 T739 pobj dependence,of
R190 T743 T741 prep on,dependence
R191 T744 T745 preconj both,cis
R192 T745 T743 pobj cis,on
R194 T747 T745 cc and,cis
R195 T748 T749 compound trans,regulation
R196 T749 T745 conj regulation,cis
R197 T750 T749 prep of,regulation
R198 T751 T752 compound gene,expression
R199 T752 T750 pobj expression,of
R200 T753 T732 punct .,present
R201 T755 T756 nsubj We,demonstrate
R202 T757 T758 advmod how,applied
R203 T758 T756 ccomp applied,demonstrate
R52 T593 T592 amod genetical,analyses
R53 T594 T592 amod genomic,analyses
R7 T543 T544 compound Fat,Mass
R8 T544 T542 compound Mass,Trait
R14 T550 T549 compound Sex,Specificity
R36 T576 T574 prep of,effects
R37 T577 T576 pobj gender,of
R38 T578 T574 prep on,effects
R39 T579 T580 det the,regulation
R40 T580 T578 pobj regulation,on
R41 T581 T580 prep of,regulation
R42 T582 T583 amod many,traits
R54 T595 T592 punct ”,analyses
R62 T603 T601 pobj which,to
R63 T604 T605 poss their,conclusions
R64 T605 T602 nsubjpass conclusions,affected
R65 T606 T602 auxpass are,affected
R75 T618 T617 amod large,intercross
R76 T619 T617 compound F2,intercross
R81 T624 T623 amod inbred,strains
R82 T625 T623 compound mouse,strains
R85 T628 T627 punct /,6J
R89 T632 T631 punct /,HeJ
R93 T636 T637 compound apolipoprotein,E
R94 T637 T638 npadvmod E,null
R95 T638 T635 amod null,background
R96 T639 T640 punct (,ApoE
R97 T640 T638 parataxis ApoE,null
R98 T641 T640 punct −,ApoE
R99 T642 T640 punct /,ApoE
R100 T643 T640 punct −,ApoE
R101 T644 T640 punct ),ApoE
R105 T649 T648 nmod BXH.ApoE,population
R106 T650 T649 punct −,BXH.ApoE
R107 T651 T649 punct /,BXH.ApoE
R108 T652 T649 punct −,BXH.ApoE
R111 T656 T655 punct “,phenotypes
R112 T657 T658 amod metabolic,syndrome
R113 T658 T655 nmod syndrome,phenotypes
R114 T659 T655 punct ”,phenotypes
R128 T675 T674 aux to,test
R129 T676 T674 advmod specifically,test
R142 T691 T690 nmod liver,loci
R143 T692 T693 nmod gene,expression
R144 T693 T690 nmod expression,loci
R145 T694 T695 amod quantitative,trait
R146 T695 T690 compound trait,loci
R150 T699 T698 amod significant,proportion
R152 T701 T698 prep of,proportion
R153 T702 T701 pobj which,of
R156 T705 T704 punct -,biased
R168 T719 T718 compound fat,mass
R172 T723 T722 amod complex,trait
R176 T727 T726 punct -,specific
R184 T737 T738 advmod remarkably,high
R185 T738 T736 amod high,degree
R189 T742 T741 punct -,dependence
R193 T746 T745 det the,cis
R204 T759 T760 det these,analyses
R205 T760 T758 nsubjpass analyses,applied
R206 T761 T758 aux can,applied
R207 T762 T758 auxpass be,applied