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2_test

Id Subject Object Predicate Lexical cue
16462940-11861025-86014481 2954-2955 11861025 denotes 1
16462940-14596945-86014482 2956-2957 14596945 denotes 2
16462940-11328966-86014483 4187-4188 11328966 denotes 3
16462940-12925895-86014483 4187-4188 12925895 denotes 3
16462940-12646919-86014483 4187-4188 12646919 denotes 3
16462940-15514660-86014484 4466-4467 15514660 denotes 6
16462940-14634638-86014485 4926-4927 14634638 denotes 7
16462940-12646919-86014486 4935-4936 12646919 denotes 5
16462940-15514893-86014487 4937-4938 15514893 denotes 8
16462940-11923494-86014488 4953-4954 11923494 denotes 9
16462940-15299141-86014488 4953-4954 15299141 denotes 9
16462940-15687266-86014488 4953-4954 15687266 denotes 9
16462940-15711547-86014488 4953-4954 15711547 denotes 9
16462940-15711545-86014488 4953-4954 15711545 denotes 9
16462940-15711544-86014488 4953-4954 15711544 denotes 9
16462940-15269782-86014488 4953-4954 15269782 denotes 9
16462940-12415114-86014488 4953-4954 12415114 denotes 9
16462940-8977046-86014489 6845-6847 8977046 denotes 18
16462940-9725853-86014490 6848-6850 9725853 denotes 19
16462940-7581446-86014491 8448-8450 7581446 denotes 20
16462940-12761058-86014492 13795-13797 12761058 denotes 21
16462940-12646919-86014493 18686-18687 12646919 denotes 5
16462940-15711544-86014494 18688-18690 15711544 denotes 15
16462940-15467983-86014495 28242-28244 15467983 denotes 22
16462940-15457344-86014495 28242-28244 15457344 denotes 22
16462940-14993241-86014495 28242-28244 14993241 denotes 22
16462940-15722954-86014495 28242-28244 15722954 denotes 22
16462940-8770600-86014496 29059-29061 8770600 denotes 26
16462940-10353911-86014496 29059-29061 10353911 denotes 26
16462940-12855751-86014496 29059-29061 12855751 denotes 26
16462940-8770600-86014497 29070-29072 8770600 denotes 26
16462940-15044658-86014498 29073-29075 15044658 denotes 29
16462940-9725853-86014499 29086-29088 9725853 denotes 19
16462940-15044658-86014500 29089-29091 15044658 denotes 29
16462940-12646919-86014501 29245-29246 12646919 denotes 5
16462940-12646919-86014502 30705-30706 12646919 denotes 5
16462940-15711544-86014503 30707-30709 15711544 denotes 15
16462940-15837804-86014504 31506-31508 15837804 denotes 30
16462940-12646919-86014505 34024-34025 12646919 denotes 5
16462940-11923494-86014506 34026-34027 11923494 denotes 9
16462940-15711544-86014507 34028-34030 15711544 denotes 15
16462940-15269782-86014508 34031-34033 15269782 denotes 16
16462940-15613385-86014509 34034-34036 15613385 denotes 31
16462940-12646919-86014510 34263-34264 12646919 denotes 5
16462940-11923494-86014511 34265-34266 11923494 denotes 9
16462940-11418218-86014512 35876-35878 11418218 denotes 32
16462940-15299141-86014513 36304-36306 15299141 denotes 11
16462940-15237224-86014514 36307-36309 15237224 denotes 33
16462940-12761058-86014515 38859-38861 12761058 denotes 21
16462940-11074587-86014516 38862-38864 11074587 denotes 34
16462940-12761058-86014517 40001-40003 12761058 denotes 21
16462940-15837804-86014518 40004-40006 15837804 denotes 30
16462940-10657304-86014519 40267-40269 10657304 denotes 35
16462940-10929718-86014520 40270-40272 10929718 denotes 36
16462940-15687290-86014521 40772-40774 15687290 denotes 37
16462940-7581446-86014522 43134-43136 7581446 denotes 20
16462940-15911579-86014523 47145-47147 15911579 denotes 38
T54173 2954-2955 11861025 denotes 1
T38470 2956-2957 14596945 denotes 2
T34552 4187-4188 11328966 denotes 3
T49441 4187-4188 12925895 denotes 3
T29806 4187-4188 12646919 denotes 3
T42793 4466-4467 15514660 denotes 6
T65566 4926-4927 14634638 denotes 7
T6696 4935-4936 12646919 denotes 5
T30843 4937-4938 15514893 denotes 8
T59192 4953-4954 11923494 denotes 9
T9450 4953-4954 15299141 denotes 9
T64174 4953-4954 15687266 denotes 9
T72429 4953-4954 15711547 denotes 9
T25873 4953-4954 15711545 denotes 9
T67278 4953-4954 15711544 denotes 9
T90746 4953-4954 15269782 denotes 9
T76675 4953-4954 12415114 denotes 9
T49860 6845-6847 8977046 denotes 18
T4167 6848-6850 9725853 denotes 19
T71418 8448-8450 7581446 denotes 20
T89292 13795-13797 12761058 denotes 21
T35968 18686-18687 12646919 denotes 5
T94994 18688-18690 15711544 denotes 15
T88409 28242-28244 15467983 denotes 22
T81197 28242-28244 15457344 denotes 22
T66925 28242-28244 14993241 denotes 22
T32941 28242-28244 15722954 denotes 22
T36625 29059-29061 8770600 denotes 26
T12720 29059-29061 10353911 denotes 26
T28858 29059-29061 12855751 denotes 26
T75575 29070-29072 8770600 denotes 26
T39830 29073-29075 15044658 denotes 29
T91815 29086-29088 9725853 denotes 19
T84579 29089-29091 15044658 denotes 29
T38280 29245-29246 12646919 denotes 5
T99391 30705-30706 12646919 denotes 5
T24477 30707-30709 15711544 denotes 15
T78375 31506-31508 15837804 denotes 30
T25092 34024-34025 12646919 denotes 5
T84101 34026-34027 11923494 denotes 9
T31541 34028-34030 15711544 denotes 15
T83474 34031-34033 15269782 denotes 16
T34266 34034-34036 15613385 denotes 31
T47912 34263-34264 12646919 denotes 5
T50432 34265-34266 11923494 denotes 9
T72512 35876-35878 11418218 denotes 32
T37989 36304-36306 15299141 denotes 11
T86378 36307-36309 15237224 denotes 33
T51202 38859-38861 12761058 denotes 21
T38688 38862-38864 11074587 denotes 34
T20492 40001-40003 12761058 denotes 21
T5696 40004-40006 15837804 denotes 30
T91259 40267-40269 10657304 denotes 35
T82162 40270-40272 10929718 denotes 36
T72428 40772-40774 15687290 denotes 37
T32461 43134-43136 7581446 denotes 20
T67165 47145-47147 15911579 denotes 38

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T472 0-7 SO:0000704 denotes Genetic
T473 12-19 SO:0001026 denotes Genomic
T474 173-183 GO:0010467 denotes expression
T475 255-260 SO:0000704 denotes genes
T476 321-331 GO:0065007 denotes regulation
T477 392-401 SO:0000704 denotes genetical
T478 402-409 SO:0001026 denotes genomic
T479 585-590 NCBITaxon:10088 denotes mouse
T480 626-640 CHEBI:39015 denotes apolipoprotein
T481 626-642 PR:000004155 denotes apolipoprotein E
T482 649-653 PR:000004155 denotes ApoE
T483 679-683 PR:000004155 denotes ApoE
T484 721-730 GO:0008152 denotes metabolic
T485 779-786 NCBITaxon:33208 denotes animals
T486 902-907 UBERON:0002107 denotes liver
T487 908-912 SO:0000704 denotes gene
T488 908-923 GO:0010467 denotes gene expression
T489 924-947 SO:0000771 denotes quantitative trait loci
T490 1049-1056 UBERON:0000991 denotes gonadal
T491 1101-1111 GO:0065007 denotes regulation
T492 1206-1235 GO:0010468 denotes regulation of gene expression
T493 1220-1224 SO:0000704 denotes gene
T494 1326-1333 UBERON:0000991 denotes gonadal
T495 1478-1485 SO:0000704 denotes genetic
T496 1486-1496 GO:0065007 denotes regulation
T1865 2877-2884 SO:0000704 denotes genetic
T1866 3016-3024 UBERON:0000002 denotes cervical
T1867 3028-3036 UBERON:0002367 denotes prostate
T1868 3249-3256 PR:000045358 denotes insulin
T1869 3391-3398 SO:0000704 denotes genetic
T1870 3457-3464 SO:0000704 denotes genetic
T1871 3483-3488 SO:0000704 denotes genic
T1872 3528-3535 SO:0000704 denotes genetic
T1873 3676-3680 SO:0000704 denotes gene
T1874 3676-3691 GO:0010467 denotes gene expression
T1875 3806-3811 SO:0000704 denotes genes
T1876 3848-3858 GO:0010467 denotes expression
T1877 4105-4110 NCBITaxon:10088 denotes mouse
T1878 4154-4163 GO:0008152 denotes metabolic
T1879 4261-4266 SO:0000704 denotes genes
T1880 4302-4309 SO:0000704 denotes genetic
T1881 4339-4346 SO:0000704 denotes genetic
T1882 4377-4389 SO:0000704 denotes genetic loci
T1883 4538-4543 NCBITaxon:9606 denotes human
T1884 4561-4568 SO:0000704 denotes genetic
T1885 4600-4605 NCBITaxon:10088 denotes mouse
T1886 4697-4703 SO:0001026 denotes genome
T1887 4724-4748 SO:0000771 denotes quantitative trait locus
T1888 4750-4753 SO:0000771 denotes QTL
T1889 4834-4841 SO:0000704 denotes genetic
T1890 4916-4920 SO:0000771 denotes QTLs
T1891 5027-5033 SO:0001026 denotes genome
T1892 5039-5043 SO:0000704 denotes gene
T1893 5039-5054 GO:0010467 denotes gene expression
T1894 5113-5117 SO:0000704 denotes gene
T1895 5113-5128 GO:0010467 denotes gene expression
T1896 5218-5225 SO:0000704 denotes genetic
T1897 5226-5236 GO:0065007 denotes regulation
T1898 5338-5342 SO:0000704 denotes gene
T1899 5443-5450 SO:0000704 denotes genetic
T1900 5494-5507 _FRAGMENT denotes regulation of
T1901 5514-5529 GO:0010468 denotes gene expression
T1902 5508-5513 UBERON:0002107 denotes liver
T1903 5514-5518 SO:0000704 denotes gene
T1904 5620-5634 CHEBI:39015 denotes apolipoprotein
T1905 5620-5636 PR:000004155 denotes apolipoprotein E
T1906 5643-5647 PR:000004155 denotes ApoE
T1907 5672-5676 PR:000004155 denotes ApoE
T1908 5776-5785 GO:0008152 denotes metabolic
T1909 5822-5829 NCBITaxon:33208 denotes animals
T1910 5900-5904 SO:0000771 denotes QTLs
T1911 5942-5946 SO:0000704 denotes gene
T1912 5942-5957 GO:0010467 denotes gene expression
T1913 5958-5962 SO:0000771 denotes QTLs
T1914 6061-6068 SO:0000704 denotes genetic
T1915 6069-6079 GO:0065007 denotes regulation
T1916 6087-6094 UBERON:0000991 denotes gonadal
T1917 6126-6131 SO:0000704 denotes genes
T4500 6169-6173 SO:0000771 denotes QTLs
T4501 6190-6197 UBERON:0000991 denotes Gonadal
T4502 6233-6237 PR:000004155 denotes ApoE
T4503 6249-6253 PR:000004155 denotes ApoE
T4504 6280-6284 PR:000004155 denotes ApoE
T4505 6344-6351 UBERON:0000991 denotes Gonadal
T4506 6443-6447 PR:000004155 denotes ApoE
T4507 6477-6481 PR:000004155 denotes ApoE
T4508 6485-6489 NCBITaxon:10088 denotes mice
T4509 6491-6498 UBERON:0000991 denotes Gonadal
T4510 6516-6523 UBERON:0003916 denotes fat pad
T4511 6561-6568 NCBITaxon:33208 denotes animals
T4512 6732-6739 UBERON:0000991 denotes gonadal
T4513 6897-6904 UBERON:0000991 denotes gonadal
T4514 6983-6987 NCBITaxon:10088 denotes mice
T4515 7044-7075 SO:0000694 denotes single nucleotide polymorphisms
T4516 7077-7081 SO:0000694 denotes SNPs
T4517 7099-7108 GO:0030849 denotes autosomes
T4518 7110-7113 SO:0000771 denotes QTL
T4519 7161-7165 SO:0000771 denotes QTLs
T4520 7216-7223 UBERON:0000991 denotes gonadal
T4521 7755-7758 SO:0000771 denotes QTL
T4522 7810-7814 SO:0000704 denotes gene
T4523 7810-7825 GO:0010467 denotes gene expression
T4524 7962-7965 SO:0000771 denotes QTL
T4525 8155-8159 SO:0000771 denotes QTLs
T4526 8172-8175 SO:0000771 denotes QTL
T4527 8372-8375 SO:0000771 denotes QTL
T4528 8384-8388 SO:0000704 denotes gene
T4529 8384-8399 GO:0010467 denotes gene expression
T4530 8453-8456 SO:0000771 denotes QTL
T4531 8626-8632 SO:0001026 denotes genome
T4532 8649-8652 SO:0000771 denotes QTL
T4533 8944-8947 SO:0000771 denotes QTL
T4534 9302-9309 UBERON:0000991 denotes gonadal
T4535 9840-9847 UBERON:0000991 denotes gonadal
T4536 9883-9889 SO:0001026 denotes genome
T4537 11361-11368 NCBITaxon:33208 denotes animals
T4538 11643-11650 NCBITaxon:33208 denotes animals
T4539 11691-11694 SO:0000771 denotes QTL
T4540 11999-12006 UBERON:0000991 denotes gonadal
T4541 12895-12902 UBERON:0000991 denotes gonadal
T4542 13082-13086 NCBITaxon:10088 denotes mice
T4543 13231-13241 GO:0065007 denotes regulation
T4544 13266-13273 UBERON:0000991 denotes gonadal
T7253 13304-13309 UBERON:0002107 denotes Liver
T7254 13316-13322 UBERON:0002107 denotes Livers
T7255 13335-13342 NCBITaxon:33208 denotes animals
T7256 13524-13529 NCBITaxon:10088 denotes mouse
T7257 13530-13541 SO:0000673 denotes transcripts
T7258 13554-13564 SO:0000673 denotes transcript
T7259 13748-13752 NCBITaxon:10088 denotes mice
T7260 13926-13937 SO:0000673 denotes transcripts
T7261 13958-13967 GO:0010467 denotes expressed
T7262 13996-14003 NCBITaxon:33208 denotes animals
T7263 14069-14074 SO:0000704 denotes genes
T7264 14121-14131 GO:0010467 denotes expression
T7265 14262-14273 SO:0000673 denotes transcripts
T7266 14293-14297 NCBITaxon:10088 denotes mice
T7267 14404-14409 UBERON:0002107 denotes liver
T7268 14410-14414 SO:0000704 denotes gene
T7269 14410-14425 GO:0010467 denotes gene expression
T7270 14460-14471 GO:0065007 denotes controlling
T7271 14495-14506 SO:0000673 denotes transcripts
T7272 14508-14518 GO:0010467 denotes expression
T7273 14877-14887 GO:0010467 denotes expression
T7274 14909-14920 SO:0000673 denotes transcripts
T7275 15164-15168 SO:0000771 denotes QTLs
T7276 15275-15279 SO:0000771 denotes QTLs
T7277 15389-15395 SO:0001026 denotes genome
T7278 15484-15487 SO:0000771 denotes QTL
T7279 15541-15544 SO:0000771 denotes QTL
T7280 15605-15608 SO:0000771 denotes QTL
T7281 15820-15824 PR:000004155 denotes ApoE
T7282 16030-16041 SO:0000673 denotes transcripts
T7283 16162-16166 SO:0000704 denotes gene
T7284 16194-16203 GO:0065007 denotes regulated
T7285 16239-16243 SO:0000704 denotes gene
T7286 17783-17789 SO:0001026 denotes genome
T7287 19019-19023 SO:0000704 denotes gene
T7288 19026-19036 GO:0010467 denotes expression
T7289 19144-19149 UBERON:0002107 denotes liver
T7290 19225-19232 SO:0000704 denotes genetic
T7291 19233-19262 GO:0010468 denotes regulation of gene expression
T7292 19247-19251 SO:0000704 denotes gene
T8423 19289-19294 SO:0000704 denotes Genes
T8424 19303-19310 UBERON:0000991 denotes Gonadal
T8425 19361-19366 UBERON:0002107 denotes liver
T8426 19367-19371 SO:0000704 denotes gene
T8427 19367-19382 GO:0010467 denotes gene expression
T8428 19391-19398 SO:0000704 denotes genetic
T8429 19399-19409 GO:0065007 denotes regulation
T8430 19413-19420 UBERON:0000991 denotes gonadal
T8431 19551-19556 SO:0000704 denotes genes
T8432 19744-19749 SO:0000704 denotes genes
T8433 19771-19776 SO:0000704 denotes genes
T10306 20120-20125 SO:0000704 denotes Genes
T10307 20163-20170 UBERON:0000991 denotes Gonadal
T10308 20330-20337 UBERON:0000991 denotes gonadal
T10309 20357-20367 SO:0000673 denotes transcript
T10310 20412-20416 SO:0000704 denotes gene
T10311 20431-20435 SO:0000704 denotes gene
T10312 20456-20460 SO:0000704 denotes gene
T10313 20524-20528 SO:0000704 denotes gene
T10314 20887-20892 SO:0000704 denotes genes
T10315 20928-20935 UBERON:0000991 denotes gonadal
T10316 20955-20960 SO:0000704 denotes genes
T10317 20994-20998 SO:0000704 denotes gene
T10318 21069-21076 SO:0000704 denotes genetic
T10319 21077-21087 GO:0065007 denotes regulation
T10320 21126-21131 SO:0000704 denotes genes
T10321 21148-21155 UBERON:0000991 denotes gonadal
T10322 22242-22247 SO:0000704 denotes genes
T10323 22264-22271 UBERON:0000991 denotes gonadal
T10324 22383-22388 SO:0000704 denotes genes
T10325 22486-22491 SO:0000704 denotes genes
T10326 22562-22567 SO:0000704 denotes Genes
T10327 22611-22618 UBERON:0000991 denotes gonadal
T10328 22717-22722 SO:0000704 denotes genes
T10329 22763-22770 SO:0000704 denotes genetic
T10330 22789-22793 SO:0000704 denotes gene
T10331 22855-22860 SO:0000704 denotes genes
T10332 22936-22941 SO:0000704 denotes genes
T10333 23010-23015 UBERON:0000062 denotes organ
T10334 23016-23026 GO:0065007 denotes regulation
T10335 23075-23082 SO:0000704 denotes genetic
T10336 23083-23093 GO:0065007 denotes regulation
T10337 23126-23131 UBERON:0002107 denotes liver
T10338 23163-23168 UBERON:0002107 denotes liver
T10339 23206-23211 UBERON:0002107 denotes liver
T10340 23271-23277 UBERON:0000479 denotes tissue
T10341 23279-23284 SO:0000704 denotes Genes
T10342 23324-23331 UBERON:0000991 denotes gonadal
T10343 23501-23507 SO:0001026 denotes genome
T10344 23593-23597 SO:0000704 denotes gene
T10345 23676-23685 GO:0065007 denotes regulated
T10346 23703-23707 SO:0000704 denotes gene
T10347 23799-23804 SO:0000704 denotes genes
T10348 23852-23861 GO:0065007 denotes regulated
T10349 23874-23881 UBERON:0000479 denotes tissues
T10350 23886-23892 UBERON:0000062 denotes organs
T10351 23962-23967 UBERON:0002107 denotes liver
T10352 23968-23972 SO:0000704 denotes gene
T10353 23968-23983 GO:0010467 denotes gene expression
T10354 24088-24093 UBERON:0002107 denotes liver
T10355 24094-24098 SO:0000704 denotes gene
T10356 24094-24109 GO:0010467 denotes gene expression
T10357 24178-24183 SO:0000704 denotes genes
T10358 24212-24222 GO:0065007 denotes controlled
T10359 24232-24239 UBERON:0000479 denotes tissues
T10360 24360-24366 SO:0001026 denotes genome
T10361 24520-24526 SO:0001026 denotes genome
T10362 24584-24589 UBERON:0002107 denotes liver
T10363 24738-24744 SO:0001026 denotes genome
T10364 24813-24824 SO:0000673 denotes transcripts
T10365 24845-24852 UBERON:0000991 denotes gonadal
T10366 25016-25023 SO:0000704 denotes genetic
T10367 25024-25034 GO:0065007 denotes regulation
T10368 25099-25104 UBERON:0002107 denotes liver
T10369 25105-25109 SO:0000704 denotes gene
T10370 25105-25120 GO:0010467 denotes gene expression
T10371 25221-25225 SO:0000704 denotes gene
T10372 25221-25236 GO:0010467 denotes gene expression
T10373 25344-25349 SO:0000704 denotes genes
T10374 25366-25373 UBERON:0000991 denotes gonadal
T10375 25387-25396 GO:0065007 denotes regulated
T10376 25460-25464 SO:0000704 denotes gene
T10377 25460-25475 GO:0010467 denotes gene expression
T10378 25483-25493 GO:0065007 denotes controlled
T10379 25622-25633 SO:0000673 denotes transcripts
T10380 25717-25724 SO:0000704 denotes genetic
T10381 25725-25754 GO:0010468 denotes regulation of gene expression
T10382 25739-25743 SO:0000704 denotes gene
T10383 25972-25979 UBERON:0000991 denotes gonadal
T10384 26075-26082 SO:0000704 denotes genetic
T10385 26083-26093 GO:0065007 denotes regulation
T10386 26097-26102 UBERON:0002107 denotes liver
T10387 26103-26108 SO:0000704 denotes genes
T10388 26193-26198 UBERON:0000062 denotes organ
T11675 27179-27184 NCBITaxon:10088 denotes mouse
T11676 27218-27225 SO:0000704 denotes genetic
T11677 27226-27236 GO:0065007 denotes regulation
T11678 27285-27294 GO:0008152 denotes metabolic
T11679 27404-27410 SO:0001026 denotes genome
T11680 27416-27420 SO:0000704 denotes gene
T11681 27416-27431 GO:0010467 denotes gene expression
T11682 27536-27543 NCBITaxon:33208 denotes animals
T11683 27671-27678 SO:0000704 denotes genetic
T11684 27679-27689 GO:0065007 denotes regulation
T13600 27720-27733 _FRAGMENT denotes Regulation of
T13601 27758-27773 GO:0010468 denotes Gene Expression
T13602 27758-27762 SO:0000704 denotes Gene
T13603 27852-27859 GO:0065007 denotes control
T13604 27947-27951 SO:0000771 denotes QTLs
T13605 28174-28177 SO:0000771 denotes QTL
T13606 28375-28378 SO:0000771 denotes QTL
T13607 28411-28417 SO:0001026 denotes genome
T13608 28520-28524 SO:0000771 denotes QTLs
T13609 28629-28633 SO:0000771 denotes QTLs
T13610 28699-28706 UBERON:0000991 denotes gonadal
T13611 28931-28935 SO:0000771 denotes QTLs
T13612 28961-28968 UBERON:0000991 denotes gonadal
T13613 28978-28991 UBERON:0007808 denotes abdominal fat
T13614 29160-29163 SO:0000771 denotes QTL
T13615 29332-29341 SO:0001024 denotes haplotype
T13616 29440-29447 SO:0000704 denotes genetic
T13617 29448-29458 GO:0065007 denotes regulation
T13618 29534-29538 PR:000004155 denotes ApoE
T13619 29663-29668 NCBITaxon:9606 denotes human
T13620 29802-29809 UBERON:0000991 denotes gonadal
T13621 29836-29843 SO:0000704 denotes genetic
T13622 29844-29854 GO:0065007 denotes regulation
T13623 29900-29905 SO:0000704 denotes genes
T13624 29975-29981 SO:0001026 denotes genome
T13625 29987-29997 GO:0010467 denotes expression
T13626 30086-30092 UBERON:0000062 denotes organs
T13627 30142-30147 SO:0000704 denotes genes
T13628 30206-30216 SO:0000673 denotes transcript
T13629 30263-30270 SO:0000704 denotes genetic
T13630 30271-30281 GO:0065007 denotes regulation
T13631 30306-30310 SO:0000704 denotes gene
T13632 30306-30321 GO:0010467 denotes gene expression
T13633 30429-30434 SO:0000704 denotes genes
T13634 30469-30475 SO:0001026 denotes genome
T13635 30552-30557 SO:0000704 denotes genes
T13636 30996-31025 GO:0010468 denotes regulation of gene expression
T13637 31010-31014 SO:0000704 denotes gene
T13638 31065-31069 SO:0000704 denotes gene
T13639 31097-31104 SO:0000704 denotes genetic
T13640 31105-31115 GO:0065007 denotes regulation
T13641 31124-31135 SO:0000673 denotes transcripts
T13642 31279-31286 SO:0000704 denotes genetic
T13643 31287-31316 GO:0010468 denotes regulation of gene expression
T13644 31301-31305 SO:0000704 denotes gene
T13645 31350-31361 CHEBI:50112 denotes sex hormone
T13646 31567-31572 NCBITaxon:10088 denotes mouse
T13647 31573-31579 SO:0001026 denotes genome
T13648 31640-31647 UBERON:0000991 denotes gonadal
T13649 31739-31746 UBERON:0000991 denotes gonadal
T13650 32107-32112 SO:0000704 denotes genes
T13651 32175-32180 SO:0000704 denotes genes
T13652 32208-32218 SO:0000673 denotes transcript
T13653 32219-32229 GO:0010467 denotes expression
T13654 32342-32347 SO:0000704 denotes genes
T13655 32443-32448 SO:0000704 denotes genes
T13656 32532-32536 SO:0000704 denotes gene
T13657 32553-32566 GO:0006412 denotes translational
T13658 32631-32640 GO:0065007 denotes regulated
T13659 32793-32798 UBERON:0000062 denotes organ
T13660 32808-32812 SO:0000704 denotes gene
T13661 32808-32823 GO:0010467 denotes gene expression
T13662 32891-32895 SO:0000704 denotes gene
T13663 32903-32909 UBERON:0000479 denotes tissue
T13664 32929-32935 UBERON:0000479 denotes tissue
T13665 32946-32953 GO:0065007 denotes control
T13666 33016-33030 UBERON:0001013 denotes adipose tissue
T13667 33046-33056 GO:0065007 denotes controlled
T13668 33069-33076 UBERON:0000479 denotes tissues
T13669 33117-33122 SO:0000704 denotes genes
T15652 33165-33170 SO:0000704 denotes Genes
T15653 33187-33194 UBERON:0000991 denotes Gonadal
T15654 33215-33221 UBERON:0000479 denotes Tissue
T15655 33231-33241 GO:0065007 denotes Regulation
T15656 33280-33285 SO:0000704 denotes genes
T15657 33352-33357 SO:0000704 denotes genes
T15658 33454-33465 SO:0000673 denotes transcripts
T15659 33470-33477 UBERON:0000991 denotes gonadal
T15660 33496-33500 SO:0000771 denotes QTLs
T15661 33565-33570 SO:0000704 denotes genes
T15662 33618-33625 UBERON:0000991 denotes gonadal
T15663 33728-33733 SO:0000704 denotes genes
T15664 33855-33860 SO:0000704 denotes genes
T15665 33916-33920 SO:0000704 denotes gene
T15666 33916-33931 GO:0010467 denotes gene expression
T15667 34389-34394 SO:0000704 denotes genes
T15668 34411-34418 UBERON:0000991 denotes gonadal
T15669 34693-34704 SO:0000673 denotes transcripts
T15670 34751-34758 UBERON:0000991 denotes gonadal
T15671 34856-34861 SO:0000704 denotes genes
T15672 34921-34931 GO:0065007 denotes regulatory
T15673 34932-34937 SO:0000704 denotes genes
T15674 35006-35011 SO:0000704 denotes genes
T15675 35048-35052 SO:0000704 denotes gene
T15676 35121-35128 UBERON:0000991 denotes gonadal
T15677 35153-35162 GO:0008152 denotes metabolic
T15678 35273-35278 SO:0000704 denotes genes
T15679 35343-35353 GO:0065007 denotes controlled
T15680 35361-35367 UBERON:0000479 denotes tissue
T15681 35505-35513 SO:0000167 denotes promoter
T15682 35526-35531 SO:0000704 denotes genes
T15683 35594-35598 SO:0000704 denotes gene
T15684 35594-35609 GO:0010467 denotes gene expression
T15685 35729-35739 GO:0065007 denotes regulation
T16846 35798-35804 SO:0001026 denotes genome
T16847 35810-35820 GO:0010467 denotes expression
T16848 35893-35900 SO:0001026 denotes genomic
T16849 36145-36152 SO:0000704 denotes genetic
T16850 36153-36163 GO:0065007 denotes regulation
T16851 36411-36415 SO:0000704 denotes gene
T16852 36411-36426 GO:0010467 denotes gene expression
T16853 36681-36688 SO:0000704 denotes genetic
T16854 36693-36700 SO:0001026 denotes genomic
T16855 36797-36802 NCBITaxon:9606 denotes human
T16856 36803-36812 GO:0008152 denotes metabolic
T16857 36833-36837 NCBITaxon:10088 denotes mice
T16858 36990-36997 SO:0000704 denotes genetic
T16859 36998-37008 GO:0065007 denotes regulation
T16860 37063-37070 UBERON:0000991 denotes gonadal
T16861 37170-37175 UBERON:0002107 denotes liver
T16862 37278-37282 SO:0000704 denotes gene
T16863 37278-37293 GO:0010467 denotes gene expression
T16864 37423-37428 SO:0000704 denotes genes
T16865 37482-37487 UBERON:0002107 denotes liver
T16866 37488-37493 SO:0000704 denotes genes
T16867 37549-37555 UBERON:0000479 denotes tissue
T16868 37577-37584 SO:0000704 denotes genetic
T16869 37585-37595 GO:0065007 denotes regulation
T16870 37731-37738 SO:0000704 denotes genetic
T16871 37739-37749 GO:0065007 denotes regulation
T17551 37805-37812 NCBITaxon:33208 denotes Animals
T17552 37817-37823 UBERON:0000479 denotes tissue
T17553 37845-37849 PR:000004155 denotes ApoE
T17554 37857-37861 PR:000004155 denotes ApoE
T17555 37949-37953 PR:000004155 denotes ApoE
T17556 37962-37966 PR:000004155 denotes ApoE
T17557 38005-38009 PR:000004155 denotes ApoE
T17558 38044-38048 NCBITaxon:10088 denotes mice
T17559 38105-38109 PR:000004155 denotes ApoE
T17560 38121-38125 PR:000004155 denotes ApoE
T17561 38137-38141 NCBITaxon:10088 denotes mice
T17562 38185-38189 NCBITaxon:10088 denotes mice
T17563 38206-38210 NCBITaxon:10088 denotes mice
T17564 38253-38257 NCBITaxon:10088 denotes mice
T17565 38263-38266 GO:0007631 denotes fed
T17566 38274-38278 CHEBI:33290 denotes Chow
T17567 38385-38396 CHEBI:16113 denotes cholesterol
T17568 38408-38412 NCBITaxon:10088 denotes Mice
T17569 38449-38454 GO:0016265 denotes death
T17570 38456-38462 UBERON:0002107 denotes livers
T17571 38517-38519 CHEBI:17997 denotes N2
T17572 38525-38541 UBERON:0003428 denotes gonadal fat pads
T18312 38606-38619 GO:0097617 denotes hybridization
T18313 38625-38635 GO:0010467 denotes expression
T18314 38672-38686 GO:0097617 denotes hybridizations
T18315 38950-38955 NCBITaxon:10088 denotes mouse
T18316 39038-39043 NCBITaxon:10088 denotes Mouse
T18317 39044-39050 UBERON:0002107 denotes livers
T18318 39105-39112 CHEBI:33893 denotes reagent
T18319 39235-39254 GO:0001171 denotes reverse transcribed
T18320 39279-39282 CHEBI:37987 denotes Cy3
T18321 39286-39289 CHEBI:37989 denotes Cy5
T18322 39290-39302 CHEBI:51217 denotes fluorochrome
T18323 39313-39316 CHEBI:37987 denotes Cy3
T18324 39320-39323 CHEBI:37989 denotes Cy5
T18325 39346-39356 GO:0097617 denotes hybridized
T18326 39425-39438 GO:0097617 denotes hybridization
T18327 39748-39752 SO:0000704 denotes Gene
T18328 39748-39763 GO:0010467 denotes Gene expression
T18329 39829-39833 NCBITaxon:10088 denotes mice
T18330 40056-40060 SO:0000704 denotes gene
T18331 40093-40102 GO:0010467 denotes expressed
T21035 40311-40318 SO:0001026 denotes Genomic
T21036 40341-40347 UBERON:0002113 denotes kidney
T21037 40351-40357 CHEBI:15882 denotes phenol
T21038 40358-40368 CHEBI:35255 denotes chloroform
T21039 40440-40444 SO:0000694 denotes SNPs
T21040 40537-40546 GO:0030849 denotes autosomes
T23044 47319-47326 UBERON:0000991 denotes gonadal
T23045 47346-47356 SO:0000673 denotes transcript
T23046 47654-47658 SO:0000704 denotes gene
T23047 48031-48036 SO:0000704 denotes Genes
T23048 48057-48064 UBERON:0000991 denotes gonadal
T23049 48167-48172 SO:0000704 denotes genes
T23050 48314-48319 UBERON:0002107 denotes liver
T23051 48362-48368 SO:0001026 denotes genome
T23052 48656-48662 SO:0001026 denotes genome
T23053 48786-48793 UBERON:0000991 denotes gonadal
T21070 45428-45432 SO:0000704 denotes gene
T21071 45428-45443 GO:0010467 denotes gene expression
T21072 45474-45477 SO:0000771 denotes QTL
T21073 45902-45906 SO:0000704 denotes gene
T21074 45902-45917 GO:0010467 denotes gene expression
T21075 45973-45977 SO:0000771 denotes QTLs
T21076 46012-46017 SO:0000704 denotes genes
T21077 46081-46085 SO:0000771 denotes QTLs
T21078 46203-46207 SO:0000771 denotes QTLs
T21079 46854-46864 GO:0010467 denotes expression
T21080 47076-47079 SO:0000771 denotes QTL
T21041 40584-40588 SO:0000694 denotes SNPs
T21042 40825-40829 SO:0000704 denotes gene
T21043 40825-40840 GO:0010467 denotes gene expression
T21044 40976-40980 SO:0000771 denotes QTLs
T21045 41248-41253 UBERON:0002107 denotes liver
T21046 41254-41265 SO:0000673 denotes transcripts
T21047 41276-41282 SO:0001026 denotes genome
T21048 41756-41759 SO:0000771 denotes QTL
T21049 42045-42048 SO:0000771 denotes QTL
T21050 42111-42114 SO:0000771 denotes QTL
T21051 42560-42564 SO:0000771 denotes QTLs
T21052 42635-42642 NCBITaxon:33208 denotes animals
T21053 42738-42742 SO:0000771 denotes QTLs
T21054 42885-42889 SO:0000771 denotes QTLs
T21055 43145-43148 SO:0000771 denotes QTL
T21056 43300-43306 SO:0001026 denotes genome
T21057 43714-43717 SO:0000771 denotes QTL
T21058 44584-44589 SO:0000704 denotes genes
T21059 44628-44633 SO:0000704 denotes genes
T21060 44646-44655 GO:0010467 denotes expressed
T21061 44663-44668 UBERON:0002107 denotes liver
T21062 44687-44691 SO:0000704 denotes gene
T21063 44851-44855 SO:0000704 denotes gene
T21064 44851-44866 GO:0010467 denotes gene expression
T21065 44940-44945 SO:0000704 denotes genes
T21066 45054-45057 SO:0000771 denotes QTL
T21067 45164-45167 SO:0000771 denotes QTL
T21068 45199-45203 SO:0000704 denotes gene
T21069 45405-45408 SO:0000771 denotes QTL
R248 T1901 T1900 _lexicallyChainedTo gene expression,regulation of
R3815 T13601 T13600 _lexicallyChainedTo Gene Expression,Regulation of

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T497 0-7 SO_EXT:0000704 denotes Genetic
T498 12-19 SO_EXT:0001026 denotes Genomic
T499 34-37 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes Fat
T500 173-183 GO:0010467 denotes expression
T501 255-260 SO_EXT:0000704 denotes genes
T502 321-331 GO:0065007 denotes regulation
T503 340-353 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T504 392-401 SO_EXT:0000704 denotes genetical
T505 402-409 SO_EXT:0001026 denotes genomic
T506 585-590 NCBITaxon:10088 denotes mouse
T507 626-640 CHEBI:39015 denotes apolipoprotein
T508 626-642 PR_EXT:000004155 denotes apolipoprotein E
T509 643-647 SO_EXT:sequence_nullness denotes null
T510 649-653 PR_EXT:000004155 denotes ApoE
T511 653-654 SO_EXT:sequence_nullness_or_absence denotes −
T512 655-656 SO_EXT:sequence_nullness_or_absence denotes −
T513 679-683 PR_EXT:000004155 denotes ApoE
T514 683-684 SO_EXT:sequence_nullness_or_absence denotes −
T515 685-686 SO_EXT:sequence_nullness_or_absence denotes −
T516 721-730 GO:0008152 denotes metabolic
T517 779-786 NCBITaxon:33208 denotes animals
T518 902-907 UBERON:0002107 denotes liver
T519 908-912 SO_EXT:0000704 denotes gene
T520 908-923 GO:0010467 denotes gene expression
T521 924-947 SO_EXT:0000771 denotes quantitative trait loci
T522 1037-1045 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes genetics
T523 1049-1056 UBERON:0000991 denotes gonadal
T524 1057-1060 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T525 1101-1111 GO:0065007 denotes regulation
T526 1206-1235 GO:0010468 denotes regulation of gene expression
T527 1220-1224 SO_EXT:0000704 denotes gene
T528 1306-1314 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes genetics
T529 1326-1333 UBERON:0000991 denotes gonadal
T530 1334-1337 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T531 1382-1388 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T532 1478-1485 SO_EXT:0000704 denotes genetic
T533 1486-1496 GO:0065007 denotes regulation
T1918 2836-2843 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes Females
T1919 2848-2853 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T1920 2877-2884 SO_EXT:0000704 denotes genetic
T1921 3016-3024 UBERON:0000002 denotes cervical
T1922 3028-3036 UBERON:0002367 denotes prostate
T1923 3132-3137 NCBITaxon_UBERON_EXT:woman denotes women
T1924 3249-3256 PR_EXT:000045358 denotes insulin
T1925 3348-3358 GO_PATO_EXT:biological_behavior denotes behavioral
T1926 3391-3398 SO_EXT:0000704 denotes genetic
T1927 3457-3464 SO_EXT:0000704 denotes genetic
T1928 3483-3488 SO_EXT:0000704 denotes genic
T1929 3528-3535 SO_EXT:0000704 denotes genetic
T1930 3536-3545 SO_EXT:sequence_variation_entity_or_quality denotes variation
T1931 3676-3680 SO_EXT:0000704 denotes gene
T1932 3676-3691 GO:0010467 denotes gene expression
T1933 3758-3765 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes Females
T1934 3770-3775 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T1935 3806-3811 SO_EXT:0000704 denotes genes
T1936 3848-3858 GO:0010467 denotes expression
T1937 3992-4005 SO_EXT:polymorphism denotes polymorphisms
T1938 4006-4015 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T1939 4105-4110 NCBITaxon:10088 denotes mouse
T1940 4142-4150 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes genetics
T1941 4154-4163 GO:0008152 denotes metabolic
T1942 4168-4176 UBERON_EXT:vascular_system_or_vasculature_or_vessel denotes vascular
T1943 4243-4250 SO_EXT:sequence_altered_entity denotes mutants
T1944 4261-4266 SO_EXT:0000704 denotes genes
T1945 4302-4309 SO_EXT:0000704 denotes genetic
T1946 4310-4319 SO_EXT:sequence_variation_entity_or_quality denotes variation
T1947 4339-4346 SO_EXT:0000704 denotes genetic
T1948 4377-4389 SO_EXT:0000704 denotes genetic loci
T1949 4420-4430 SO_EXT:sequence_variation_entity_or_quality denotes variations
T1950 4538-4543 NCBITaxon:9606 denotes human
T1951 4561-4568 SO_EXT:0000704 denotes genetic
T1952 4600-4605 NCBITaxon:10088 denotes mouse
T1953 4697-4703 SO_EXT:0001026 denotes genome
T1954 4724-4748 SO_EXT:0000771 denotes quantitative trait locus
T1955 4750-4753 SO_EXT:0000771 denotes QTL
T1956 4799-4818 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosomal regions
T1957 4834-4841 SO_EXT:0000704 denotes genetic
T1958 4842-4851 SO_EXT:sequence_variation_entity_or_quality denotes variation
T1959 4916-4920 SO_EXT:0000771 denotes QTLs
T1960 5027-5033 SO_EXT:0001026 denotes genome
T1961 5039-5043 SO_EXT:0000704 denotes gene
T1962 5039-5054 GO:0010467 denotes gene expression
T1963 5101-5109 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes genetics
T1964 5113-5117 SO_EXT:0000704 denotes gene
T1965 5113-5128 GO:0010467 denotes gene expression
T1966 5218-5225 SO_EXT:0000704 denotes genetic
T1967 5226-5236 GO:0065007 denotes regulation
T1968 5338-5342 SO_EXT:0000704 denotes gene
T1969 5443-5450 SO_EXT:0000704 denotes genetic
T1970 5494-5507 _FRAGMENT denotes regulation of
T1971 5514-5529 GO:0010468 denotes gene expression
T1972 5508-5513 UBERON:0002107 denotes liver
T1973 5514-5518 SO_EXT:0000704 denotes gene
T1974 5620-5634 CHEBI:39015 denotes apolipoprotein
T1975 5620-5636 PR_EXT:000004155 denotes apolipoprotein E
T1976 5637-5641 SO_EXT:sequence_nullness denotes null
T1977 5643-5647 PR_EXT:000004155 denotes ApoE
T1978 5647-5648 SO_EXT:sequence_nullness_or_absence denotes −
T1979 5649-5650 SO_EXT:sequence_nullness_or_absence denotes −
T1980 5672-5676 PR_EXT:000004155 denotes ApoE
T1981 5676-5677 SO_EXT:sequence_nullness_or_absence denotes −
T1982 5678-5679 SO_EXT:sequence_nullness_or_absence denotes −
T1983 5776-5785 GO:0008152 denotes metabolic
T1984 5822-5829 NCBITaxon:33208 denotes animals
T1985 5900-5904 SO_EXT:0000771 denotes QTLs
T1986 5942-5946 SO_EXT:0000704 denotes gene
T1987 5942-5957 GO:0010467 denotes gene expression
T1988 5958-5962 SO_EXT:0000771 denotes QTLs
T1989 6061-6068 SO_EXT:0000704 denotes genetic
T1990 6069-6079 GO:0065007 denotes regulation
T1991 6087-6094 UBERON:0000991 denotes gonadal
T1992 6095-6098 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T1993 6126-6131 SO_EXT:0000704 denotes genes
T4545 6169-6173 SO_EXT:0000771 denotes QTLs
T4546 6190-6197 UBERON:0000991 denotes Gonadal
T4547 6198-6201 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes Fat
T4548 6233-6237 PR_EXT:000004155 denotes ApoE
T4549 6237-6238 SO_EXT:sequence_nullness_or_absence denotes −
T4550 6239-6240 SO_EXT:sequence_nullness_or_absence denotes −
T4551 6249-6253 PR_EXT:000004155 denotes ApoE
T4552 6253-6254 SO_EXT:sequence_nullness_or_absence denotes −
T4553 6255-6256 SO_EXT:sequence_nullness_or_absence denotes −
T4554 6280-6284 PR_EXT:000004155 denotes ApoE
T4555 6284-6285 SO_EXT:sequence_nullness_or_absence denotes −
T4556 6286-6287 SO_EXT:sequence_nullness_or_absence denotes −
T4557 6344-6351 UBERON:0000991 denotes Gonadal
T4558 6352-6355 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T4559 6443-6447 PR_EXT:000004155 denotes ApoE
T4560 6447-6448 SO_EXT:sequence_nullness_or_absence denotes −
T4561 6449-6450 SO_EXT:sequence_nullness_or_absence denotes −
T4562 6477-6481 PR_EXT:000004155 denotes ApoE
T4563 6481-6482 SO_EXT:sequence_nullness_or_absence denotes −
T4564 6483-6484 SO_EXT:sequence_nullness_or_absence denotes −
T4565 6485-6489 NCBITaxon:10088 denotes mice
T4566 6491-6498 UBERON:0000991 denotes Gonadal
T4567 6499-6502 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T4568 6516-6519 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T4569 6516-6523 UBERON:0003916 denotes fat pad
T4570 6561-6568 NCBITaxon:33208 denotes animals
T4571 6732-6739 UBERON:0000991 denotes gonadal
T4572 6740-6743 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T4573 6767-6774 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T4574 6787-6792 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T4575 6897-6904 UBERON:0000991 denotes gonadal
T4576 6905-6908 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T4577 6983-6987 NCBITaxon:10088 denotes mice
T4578 7044-7075 SO_EXT:0000694 denotes single nucleotide polymorphisms
T4579 7051-7061 CHEBI_SO_EXT:nucleotide denotes nucleotide
T4580 7077-7081 SO_EXT:0000694 denotes SNPs
T4581 7099-7108 GO:0030849 denotes autosomes
T4582 7110-7113 SO_EXT:0000771 denotes QTL
T4583 7161-7165 SO_EXT:0000771 denotes QTLs
T4584 7216-7223 UBERON:0000991 denotes gonadal
T4585 7224-7227 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T4586 7263-7269 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T4587 7324-7331 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4588 7755-7758 SO_EXT:0000771 denotes QTL
T4589 7810-7814 SO_EXT:0000704 denotes gene
T4590 7810-7825 GO:0010467 denotes gene expression
T4591 7962-7965 SO_EXT:0000771 denotes QTL
T4592 8155-8159 SO_EXT:0000771 denotes QTLs
T4593 8172-8175 SO_EXT:0000771 denotes QTL
T4594 8224-8232 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T4595 8372-8375 SO_EXT:0000771 denotes QTL
T4596 8384-8388 SO_EXT:0000704 denotes gene
T4597 8384-8399 GO:0010467 denotes gene expression
T4598 8453-8456 SO_EXT:0000771 denotes QTL
T4599 8626-8632 SO_EXT:0001026 denotes genome
T4600 8649-8652 SO_EXT:0000771 denotes QTL
T4601 8944-8947 SO_EXT:0000771 denotes QTL
T4602 9222-9232 GO_SO_EXT:chromosome denotes Chromosome
T4603 9258-9269 GO_SO_EXT:chromosome denotes Chromosomes
T4604 9302-9309 UBERON:0000991 denotes gonadal
T4605 9310-9313 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T4606 9598-9608 GO_SO_EXT:chromosome denotes Chromosome
T4607 9840-9847 UBERON:0000991 denotes gonadal
T4608 9848-9851 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T4609 9883-9889 SO_EXT:0001026 denotes genome
T4610 11300-11310 GO_SO_EXT:chromosome denotes Chromosome
T4611 11361-11368 NCBITaxon:33208 denotes animals
T4612 11450-11460 GO_SO_EXT:chromosome denotes Chromosome
T4613 11469-11476 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T4614 11557-11562 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T4615 11643-11650 NCBITaxon:33208 denotes animals
T4616 11691-11694 SO_EXT:0000771 denotes QTL
T4617 11961-11969 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T4618 11999-12006 UBERON:0000991 denotes gonadal
T4619 12007-12010 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T4620 12090-12101 GO_SO_EXT:chromosome denotes Chromosomes
T4621 12141-12144 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T4622 12196-12206 GO_SO_EXT:chromosome denotes Chromosome
T4623 12244-12249 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T4624 12254-12261 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T4625 12308-12315 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T4626 12332-12339 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T4627 12362-12367 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T4628 12435-12445 GO_SO_EXT:chromosome denotes Chromosome
T4629 12481-12488 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T4630 12508-12513 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T4631 12895-12902 UBERON:0000991 denotes gonadal
T4632 12903-12906 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T4633 12950-12957 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T4634 13000-13008 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T4635 13072-13078 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T4636 13082-13086 NCBITaxon:10088 denotes mice
T4637 13098-13103 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T4638 13231-13241 GO:0065007 denotes regulation
T4639 13266-13273 UBERON:0000991 denotes gonadal
T4640 13274-13277 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T7293 13304-13309 UBERON:0002107 denotes Liver
T7294 13316-13322 UBERON:0002107 denotes Livers
T7295 13335-13342 NCBITaxon:33208 denotes animals
T7296 13348-13354 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T7297 13360-13364 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T7298 13386-13401 CHEBI_SO_EXT:oligonucleotide denotes oligonucleotide
T7299 13506-13512 CHEBI_SO_EXT:molecular_probe denotes probes
T7300 13524-13529 NCBITaxon:10088 denotes mouse
T7301 13530-13541 SO_EXT:0000673 denotes transcripts
T7302 13554-13564 SO_EXT:0000673 denotes transcript
T7303 13748-13752 NCBITaxon:10088 denotes mice
T7304 13926-13937 SO_EXT:0000673 denotes transcripts
T7305 13958-13967 GO:0010467 denotes expressed
T7306 13996-14003 NCBITaxon:33208 denotes animals
T7307 14069-14074 SO_EXT:0000704 denotes genes
T7308 14121-14131 GO:0010467 denotes expression
T7309 14262-14273 SO_EXT:0000673 denotes transcripts
T7310 14293-14297 NCBITaxon:10088 denotes mice
T7311 14338-14342 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T7312 14347-14353 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T7313 14404-14409 UBERON:0002107 denotes liver
T7314 14410-14414 SO_EXT:0000704 denotes gene
T7315 14410-14425 GO:0010467 denotes gene expression
T7316 14460-14471 GO:0065007 denotes controlling
T7317 14495-14506 SO_EXT:0000673 denotes transcripts
T7318 14508-14518 GO:0010467 denotes expression
T7319 14877-14887 GO:0010467 denotes expression
T7320 14909-14920 SO_EXT:0000673 denotes transcripts
T7321 15164-15168 SO_EXT:0000771 denotes QTLs
T7322 15275-15279 SO_EXT:0000771 denotes QTLs
T7323 15389-15395 SO_EXT:0001026 denotes genome
T7324 15484-15487 SO_EXT:0000771 denotes QTL
T7325 15541-15544 SO_EXT:0000771 denotes QTL
T7326 15605-15608 SO_EXT:0000771 denotes QTL
T7327 15820-15824 PR_EXT:000004155 denotes ApoE
T7328 15824-15825 SO_EXT:sequence_nullness_or_absence denotes −
T7329 15826-15827 SO_EXT:sequence_nullness_or_absence denotes −
T7330 16030-16041 SO_EXT:0000673 denotes transcripts
T7331 16123-16124 CHEBI_SO_EXT:base denotes b
T7332 16162-16166 SO_EXT:0000704 denotes gene
T7333 16194-16203 GO:0065007 denotes regulated
T7334 16218-16227 SO_EXT:sequence_variation_entity_or_quality denotes variation
T7335 16239-16243 SO_EXT:0000704 denotes gene
T7336 17783-17789 SO_EXT:0001026 denotes genome
T7337 17865-17876 GO_SO_EXT:chromosome denotes Chromosomes
T7338 17947-17955 GO_PATO_EXT:biological_localization_process_or_quality denotes localize
T7339 17968-17978 _FRAGMENT denotes regions on
T7340 17984-17994 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosome
T7341 18121-18136 GO_EXT:transcription denotes transcriptional
T7342 18261-18271 GO_SO_EXT:chromosome denotes Chromosome
T7343 18455-18463 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T7344 18779-18789 SO_EXT:sequence_variation_entity_or_quality denotes variations
T7345 18800-18813 GO_EXT:transcription denotes transcription
T7346 19019-19023 SO_EXT:0000704 denotes gene
T7347 19026-19036 GO:0010467 denotes expression
T7348 19144-19149 UBERON:0002107 denotes liver
T7349 19225-19232 SO_EXT:0000704 denotes genetic
T7350 19233-19262 GO:0010468 denotes regulation of gene expression
T7351 19247-19251 SO_EXT:0000704 denotes gene
T8434 19289-19294 SO_EXT:0000704 denotes Genes
T8435 19303-19310 UBERON:0000991 denotes Gonadal
T8436 19311-19314 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes Fat
T8437 19361-19366 UBERON:0002107 denotes liver
T8438 19367-19371 SO_EXT:0000704 denotes gene
T8439 19367-19382 GO:0010467 denotes gene expression
T8440 19391-19398 SO_EXT:0000704 denotes genetic
T8441 19399-19409 GO:0065007 denotes regulation
T8442 19413-19420 UBERON:0000991 denotes gonadal
T8443 19421-19424 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T8444 19551-19556 SO_EXT:0000704 denotes genes
T8445 19716-19719 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T8446 19744-19749 SO_EXT:0000704 denotes genes
T8447 19771-19776 SO_EXT:0000704 denotes genes
T10389 20120-20125 SO_EXT:0000704 denotes Genes
T10390 20163-20170 UBERON:0000991 denotes Gonadal
T10391 20171-20174 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes Fat
T10392 20203-20219 CHEBI_SO_EXT:oligonucleotide denotes oligonucleotides
T10393 20330-20337 UBERON:0000991 denotes gonadal
T10394 20338-20341 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10395 20357-20367 SO_EXT:0000673 denotes transcript
T10396 20412-20416 SO_EXT:0000704 denotes gene
T10397 20431-20435 SO_EXT:0000704 denotes gene
T10398 20456-20460 SO_EXT:0000704 denotes gene
T10399 20524-20528 SO_EXT:0000704 denotes gene
T10400 20887-20892 SO_EXT:0000704 denotes genes
T10401 20928-20935 UBERON:0000991 denotes gonadal
T10402 20936-20939 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10403 20955-20960 SO_EXT:0000704 denotes genes
T10404 20994-20998 SO_EXT:0000704 denotes gene
T10405 21069-21076 SO_EXT:0000704 denotes genetic
T10406 21077-21087 GO:0065007 denotes regulation
T10407 21126-21131 SO_EXT:0000704 denotes genes
T10408 21148-21155 UBERON:0000991 denotes gonadal
T10409 21156-21159 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10410 22242-22247 SO_EXT:0000704 denotes genes
T10411 22264-22271 UBERON:0000991 denotes gonadal
T10412 22272-22275 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10413 22340-22352 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T10414 22383-22388 SO_EXT:0000704 denotes genes
T10415 22411-22414 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10416 22486-22491 SO_EXT:0000704 denotes genes
T10417 22562-22567 SO_EXT:0000704 denotes Genes
T10418 22611-22618 UBERON:0000991 denotes gonadal
T10419 22619-22622 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10420 22678-22681 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10421 22717-22722 SO_EXT:0000704 denotes genes
T10422 22763-22770 SO_EXT:0000704 denotes genetic
T10423 22771-22780 SO_EXT:sequence_variation_entity_or_quality denotes variation
T10424 22789-22793 SO_EXT:0000704 denotes gene
T10425 22855-22860 SO_EXT:0000704 denotes genes
T10426 22936-22941 SO_EXT:0000704 denotes genes
T10427 23010-23015 UBERON:0000062 denotes organ
T10428 23016-23026 GO:0065007 denotes regulation
T10429 23075-23082 SO_EXT:0000704 denotes genetic
T10430 23083-23093 GO:0065007 denotes regulation
T10431 23126-23131 UBERON:0002107 denotes liver
T10432 23163-23168 UBERON:0002107 denotes liver
T10433 23206-23211 UBERON:0002107 denotes liver
T10434 23212-23227 GO_EXT:transcription denotes transcriptional
T10435 23271-23277 UBERON:0000479 denotes tissue
T10436 23279-23284 SO_EXT:0000704 denotes Genes
T10437 23324-23331 UBERON:0000991 denotes gonadal
T10438 23332-23335 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10439 23382-23385 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10440 23501-23507 SO_EXT:0001026 denotes genome
T10441 23593-23597 SO_EXT:0000704 denotes gene
T10442 23623-23626 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10443 23651-23664 GO_EXT:transcription denotes transcription
T10445 23703-23707 SO_EXT:0000704 denotes gene
T10446 23739-23742 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10447 23761-23771 GO_PATO_EXT:biological_localization_process_or_quality denotes localizing
T10448 23799-23804 SO_EXT:0000704 denotes genes
T10449 23835-23838 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10450 23852-23861 GO:0065007 denotes regulated
T10451 23874-23881 UBERON:0000479 denotes tissues
T10452 23886-23892 UBERON:0000062 denotes organs
T10453 23923-23926 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10454 23962-23967 UBERON:0002107 denotes liver
T10455 23968-23972 SO_EXT:0000704 denotes gene
T10456 23968-23983 GO:0010467 denotes gene expression
T10457 24088-24093 UBERON:0002107 denotes liver
T10458 24094-24098 SO_EXT:0000704 denotes gene
T10459 24094-24109 GO:0010467 denotes gene expression
T10460 24148-24157 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T10461 24178-24183 SO_EXT:0000704 denotes genes
T10462 24212-24222 GO:0065007 denotes controlled
T10463 24232-24239 UBERON:0000479 denotes tissues
T10464 24360-24366 SO_EXT:0001026 denotes genome
T10465 24520-24526 SO_EXT:0001026 denotes genome
T10466 24584-24589 UBERON:0002107 denotes liver
T10467 24738-24744 SO_EXT:0001026 denotes genome
T10468 24750-24769 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes locus on Chromosome
T10469 24813-24824 SO_EXT:0000673 denotes transcripts
T10470 24845-24852 UBERON:0000991 denotes gonadal
T10471 24853-24856 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10472 24941-24944 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10473 24969-24979 GO_SO_EXT:chromosome denotes Chromosome
T10474 25016-25023 SO_EXT:0000704 denotes genetic
T10475 25024-25034 GO:0065007 denotes regulation
T10476 25038-25041 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10477 25055-25065 _FRAGMENT denotes Chromosome
T10478 25069-25074 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes locus
T10479 25099-25104 UBERON:0002107 denotes liver
T10480 25105-25109 SO_EXT:0000704 denotes gene
T10481 25105-25120 GO:0010467 denotes gene expression
T10482 25145-25148 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10483 25198-25208 _FRAGMENT denotes Chromosome
T10484 25212-25217 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes locus
T10485 25221-25225 SO_EXT:0000704 denotes gene
T10486 25221-25236 GO:0010467 denotes gene expression
T10487 25290-25298 GO_PATO_EXT:biological_localization_process_or_quality denotes localize
T10488 25302-25312 GO_SO_EXT:chromosome denotes Chromosome
T10489 25344-25349 SO_EXT:0000704 denotes genes
T10490 25366-25373 UBERON:0000991 denotes gonadal
T10491 25374-25377 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10492 25387-25396 GO:0065007 denotes regulated
T10493 25411-25423 SO_EXT:polymorphism denotes polymorphism
T10494 25460-25464 SO_EXT:0000704 denotes gene
T10495 25460-25475 GO:0010467 denotes gene expression
T10496 25483-25493 GO:0065007 denotes controlled
T10497 25580-25585 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T10498 25590-25597 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T10499 25622-25633 SO_EXT:0000673 denotes transcripts
T10500 25661-25671 GO_SO_EXT:chromosome denotes Chromosome
T10501 25688-25695 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T10502 25717-25724 SO_EXT:0000704 denotes genetic
T10503 25725-25754 GO:0010468 denotes regulation of gene expression
T10504 25739-25743 SO_EXT:0000704 denotes gene
T10505 25760-25765 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T10506 25784-25790 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T10507 25870-25880 _FRAGMENT denotes Chromosome
T10508 25884-25889 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes locus
T10509 25972-25979 UBERON:0000991 denotes gonadal
T10510 25980-25983 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10511 26075-26082 SO_EXT:0000704 denotes genetic
T10512 26083-26093 GO:0065007 denotes regulation
T10513 26097-26102 UBERON:0002107 denotes liver
T10514 26103-26108 SO_EXT:0000704 denotes genes
T10515 26125-26128 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T10516 26193-26198 UBERON:0000062 denotes organ
T11685 27179-27184 NCBITaxon:10088 denotes mouse
T11686 27218-27225 SO_EXT:0000704 denotes genetic
T11687 27226-27236 GO:0065007 denotes regulation
T11688 27285-27294 GO:0008152 denotes metabolic
T11689 27390-27398 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes genetics
T11690 27404-27410 SO_EXT:0001026 denotes genome
T11691 27416-27420 SO_EXT:0000704 denotes gene
T11692 27416-27431 GO:0010467 denotes gene expression
T11693 27536-27543 NCBITaxon:33208 denotes animals
T11694 27671-27678 SO_EXT:0000704 denotes genetic
T11695 27679-27689 GO:0065007 denotes regulation
T13670 27720-27733 _FRAGMENT denotes Regulation of
T13671 27758-27773 GO:0010468 denotes Gene Expression
T13672 27758-27762 SO_EXT:0000704 denotes Gene
T13673 27808-27815 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T13674 27820-27825 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T13675 27852-27859 GO:0065007 denotes control
T13676 27947-27951 SO_EXT:0000771 denotes QTLs
T13677 28174-28177 SO_EXT:0000771 denotes QTL
T13678 28375-28378 SO_EXT:0000771 denotes QTL
T13679 28411-28417 SO_EXT:0001026 denotes genome
T13680 28426-28436 GO_SO_EXT:chromosome denotes Chromosome
T13681 28520-28524 SO_EXT:0000771 denotes QTLs
T13682 28577-28584 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T13683 28589-28594 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T13684 28629-28633 SO_EXT:0000771 denotes QTLs
T13685 28699-28706 UBERON:0000991 denotes gonadal
T13686 28707-28710 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13687 28725-28736 GO_SO_EXT:chromosome denotes Chromosomes
T13688 28827-28834 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T13689 28931-28935 SO_EXT:0000771 denotes QTLs
T13690 28961-28968 UBERON:0000991 denotes gonadal
T13691 28969-28972 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13692 28978-28991 UBERON:0007808 denotes abdominal fat
T13693 28988-28991 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13694 29044-29055 GO_SO_EXT:chromosome denotes Chromosomes
T13695 29128-29138 GO_SO_EXT:chromosome denotes Chromosome
T13696 29160-29163 SO_EXT:0000771 denotes QTL
T13697 29184-29194 GO_SO_EXT:chromosome denotes Chromosome
T13698 29207-29210 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13699 29332-29341 SO_EXT:0001024 denotes haplotype
T13700 29440-29447 SO_EXT:0000704 denotes genetic
T13701 29448-29458 GO:0065007 denotes regulation
T13702 29521-29533 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T13703 29534-29538 PR_EXT:000004155 denotes ApoE
T13704 29538-29539 SO_EXT:sequence_nullness_or_absence denotes −
T13705 29540-29541 SO_EXT:sequence_nullness_or_absence denotes −
T13706 29566-29569 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13707 29663-29668 NCBITaxon:9606 denotes human
T13708 29708-29714 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T13709 29802-29809 UBERON:0000991 denotes gonadal
T13710 29810-29817 CHEBI_GO_EXT:hormone denotes hormone
T13711 29818-29828 GO_EXT:secretion_entity_or_process denotes secretions
T13712 29836-29843 SO_EXT:0000704 denotes genetic
T13713 29844-29854 GO:0065007 denotes regulation
T13714 29900-29905 SO_EXT:0000704 denotes genes
T13715 29975-29981 SO_EXT:0001026 denotes genome
T13716 29987-29997 GO:0010467 denotes expression
T13717 30060-30073 GO_EXT:transcription denotes transcription
T13718 30086-30092 UBERON:0000062 denotes organs
T13719 30142-30147 SO_EXT:0000704 denotes genes
T13720 30206-30216 SO_EXT:0000673 denotes transcript
T13721 30263-30270 SO_EXT:0000704 denotes genetic
T13722 30271-30281 GO:0065007 denotes regulation
T13723 30306-30310 SO_EXT:0000704 denotes gene
T13724 30306-30321 GO:0010467 denotes gene expression
T13725 30364-30374 SO_EXT:sequence_variation_entity_or_quality denotes variations
T13726 30391-30404 GO_EXT:transcription denotes transcription
T13727 30429-30434 SO_EXT:0000704 denotes genes
T13728 30469-30475 SO_EXT:0001026 denotes genome
T13729 30552-30557 SO_EXT:0000704 denotes genes
T13730 30772-30782 SO_EXT:sequence_variation_entity_or_quality denotes variations
T13731 30793-30806 GO_EXT:transcription denotes transcription
T13732 30996-31025 GO:0010468 denotes regulation of gene expression
T13733 31010-31014 SO_EXT:0000704 denotes gene
T13734 31040-31053 SO_EXT:polymorphism denotes polymorphisms
T13735 31065-31069 SO_EXT:0000704 denotes gene
T13736 31097-31104 SO_EXT:0000704 denotes genetic
T13737 31105-31115 GO:0065007 denotes regulation
T13738 31124-31135 SO_EXT:0000673 denotes transcripts
T13739 31217-31225 CHEBI_GO_EXT:hormone denotes hormones
T13740 31279-31286 SO_EXT:0000704 denotes genetic
T13741 31287-31316 GO:0010468 denotes regulation of gene expression
T13742 31301-31305 SO_EXT:0000704 denotes gene
T13743 31350-31361 CHEBI_EXT:50112 denotes sex hormone
T13744 31354-31361 CHEBI_GO_EXT:hormone denotes hormone
T13745 31538-31549 SO_EXT:polymorphism denotes polymorphic
T13746 31567-31572 NCBITaxon:10088 denotes mouse
T13747 31573-31579 SO_EXT:0001026 denotes genome
T13748 31640-31647 UBERON:0000991 denotes gonadal
T13749 31648-31651 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13750 31739-31746 UBERON:0000991 denotes gonadal
T13751 31747-31750 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T13752 32107-32112 SO_EXT:0000704 denotes genes
T13753 32175-32180 SO_EXT:0000704 denotes genes
T13754 32208-32218 SO_EXT:0000673 denotes transcript
T13755 32219-32229 GO:0010467 denotes expression
T13756 32271-32283 SO_EXT:polymorphism denotes polymorphism
T13757 32342-32347 SO_EXT:0000704 denotes genes
T13758 32443-32448 SO_EXT:0000704 denotes genes
T13759 32483-32496 SO_EXT:polymorphism denotes polymorphisms
T13760 32532-32536 SO_EXT:0000704 denotes gene
T13761 32549-32580 GO_SO_EXT:post_translational_modification_entity_or_process denotes posttranslational modifications
T13762 32631-32640 GO:0065007 denotes regulated
T13763 32675-32688 GO_EXT:transcription denotes transcription
T13764 32692-32696 CHEBI_SO_EXT:mRNA denotes mRNA
T13765 32793-32798 UBERON:0000062 denotes organ
T13766 32808-32812 SO_EXT:0000704 denotes gene
T13767 32808-32823 GO:0010467 denotes gene expression
T13768 32891-32895 SO_EXT:0000704 denotes gene
T13769 32903-32909 UBERON:0000479 denotes tissue
T13770 32929-32935 UBERON:0000479 denotes tissue
T13771 32946-32953 GO:0065007 denotes control
T13772 33016-33030 UBERON:0001013 denotes adipose tissue
T13773 33046-33056 GO:0065007 denotes controlled
T13774 33069-33076 UBERON:0000479 denotes tissues
T13775 33117-33122 SO_EXT:0000704 denotes genes
T15686 33165-33170 SO_EXT:0000704 denotes Genes
T15687 33187-33194 UBERON:0000991 denotes Gonadal
T15688 33195-33198 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes Fat
T15689 33215-33221 UBERON:0000479 denotes Tissue
T15690 33231-33241 GO:0065007 denotes Regulation
T15691 33280-33285 SO_EXT:0000704 denotes genes
T15692 33306-33309 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T15693 33352-33357 SO_EXT:0000704 denotes genes
T15694 33454-33465 SO_EXT:0000673 denotes transcripts
T15695 33470-33477 UBERON:0000991 denotes gonadal
T15696 33478-33481 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T15697 33496-33500 SO_EXT:0000771 denotes QTLs
T15698 33565-33570 SO_EXT:0000704 denotes genes
T15699 33618-33625 UBERON:0000991 denotes gonadal
T15700 33626-33629 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T15701 33728-33733 SO_EXT:0000704 denotes genes
T15702 33855-33860 SO_EXT:0000704 denotes genes
T15703 33904-33912 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes genetics
T15704 33916-33920 SO_EXT:0000704 denotes gene
T15705 33916-33931 GO:0010467 denotes gene expression
T15706 34157-34170 SO_EXT:polymorphism denotes polymorphisms
T15707 34307-34319 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T15708 34389-34394 SO_EXT:0000704 denotes genes
T15709 34411-34418 UBERON:0000991 denotes gonadal
T15710 34419-34422 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T15711 34561-34571 GO_SO_EXT:chromosome denotes Chromosome
T15712 34648-34651 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T15713 34693-34704 SO_EXT:0000673 denotes transcripts
T15714 34751-34758 UBERON:0000991 denotes gonadal
T15715 34759-34762 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T15716 34773-34785 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T15717 34856-34861 SO_EXT:0000704 denotes genes
T15718 34921-34931 GO:0065007 denotes regulatory
T15719 34932-34937 SO_EXT:0000704 denotes genes
T15720 35006-35011 SO_EXT:0000704 denotes genes
T15721 35048-35052 SO_EXT:0000704 denotes gene
T15722 35095-35103 GO_EXT:reaction_or_response denotes reacting
T15723 35121-35128 UBERON:0000991 denotes gonadal
T15724 35129-35132 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T15725 35153-35162 GO:0008152 denotes metabolic
T15726 35273-35278 SO_EXT:0000704 denotes genes
T15727 35343-35353 GO:0065007 denotes controlled
T15728 35361-35367 UBERON:0000479 denotes tissue
T15729 35394-35404 _FRAGMENT denotes Chromosome
T15730 35408-35413 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes locus
T15731 35481-35488 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T15732 35505-35513 SO_EXT:0000167 denotes promoter
T15733 35526-35531 SO_EXT:0000704 denotes genes
T15734 35594-35598 SO_EXT:0000704 denotes gene
T15735 35594-35609 GO:0010467 denotes gene expression
T15736 35729-35739 GO:0065007 denotes regulation
T16872 35784-35792 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes genetics
T16873 35798-35804 SO_EXT:0001026 denotes genome
T16874 35810-35820 GO:0010467 denotes expression
T16875 35893-35900 SO_EXT:0001026 denotes genomic
T16876 36145-36152 SO_EXT:0000704 denotes genetic
T16877 36153-36163 GO:0065007 denotes regulation
T16878 36411-36415 SO_EXT:0000704 denotes gene
T16879 36411-36426 GO:0010467 denotes gene expression
T16880 36430-36437 CHEBI_PR_EXT:protein denotes protein
T16881 36484-36492 CHEBI_GO_EXT:hormone denotes hormonal
T16882 36543-36550 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T16883 36555-36560 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T16884 36681-36688 SO_EXT:0000704 denotes genetic
T16885 36693-36700 SO_EXT:0001026 denotes genomic
T16886 36797-36802 NCBITaxon:9606 denotes human
T16887 36803-36812 GO:0008152 denotes metabolic
T16888 36833-36837 NCBITaxon:10088 denotes mice
T16889 36990-36997 SO_EXT:0000704 denotes genetic
T16890 36998-37008 GO:0065007 denotes regulation
T16891 37063-37070 UBERON:0000991 denotes gonadal
T16892 37071-37074 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T16893 37115-37122 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T16894 37170-37175 UBERON:0002107 denotes liver
T16895 37278-37282 SO_EXT:0000704 denotes gene
T16896 37278-37293 GO:0010467 denotes gene expression
T16897 37423-37428 SO_EXT:0000704 denotes genes
T16898 37454-37466 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T16899 37482-37487 UBERON:0002107 denotes liver
T16900 37488-37493 SO_EXT:0000704 denotes genes
T16901 37549-37555 UBERON:0000479 denotes tissue
T16902 37577-37584 SO_EXT:0000704 denotes genetic
T16903 37585-37595 GO:0065007 denotes regulation
T16904 37731-37738 SO_EXT:0000704 denotes genetic
T16905 37739-37749 GO:0065007 denotes regulation
T17573 37805-37812 NCBITaxon:33208 denotes Animals
T17574 37817-37823 UBERON:0000479 denotes tissue
T17575 37845-37849 PR_EXT:000004155 denotes ApoE
T17576 37849-37850 SO_EXT:sequence_nullness_or_absence denotes −
T17577 37851-37852 SO_EXT:sequence_nullness_or_absence denotes −
T17578 37857-37861 PR_EXT:000004155 denotes ApoE
T17579 37861-37862 SO_EXT:sequence_nullness_or_absence denotes −
T17580 37863-37864 SO_EXT:sequence_nullness_or_absence denotes −
T17581 37949-37953 PR_EXT:000004155 denotes ApoE
T17582 37953-37954 SO_EXT:sequence_nullness_or_absence denotes −
T17583 37955-37956 SO_EXT:sequence_nullness_or_absence denotes −
T17584 37962-37966 PR_EXT:000004155 denotes ApoE
T17585 37966-37967 SO_EXT:sequence_nullness_or_absence denotes −
T17586 37968-37969 SO_EXT:sequence_nullness_or_absence denotes −
T17587 38005-38009 PR_EXT:000004155 denotes ApoE
T17588 38009-38010 SO_EXT:sequence_nullness_or_absence denotes −
T17589 38011-38012 SO_EXT:sequence_nullness_or_absence denotes −
T17590 38044-38048 NCBITaxon:10088 denotes mice
T17591 38105-38109 PR_EXT:000004155 denotes ApoE
T17592 38109-38110 SO_EXT:sequence_nullness_or_absence denotes −
T17593 38111-38112 SO_EXT:sequence_nullness_or_absence denotes −
T17594 38121-38125 PR_EXT:000004155 denotes ApoE
T17595 38125-38126 SO_EXT:sequence_nullness_or_absence denotes −
T17596 38127-38128 SO_EXT:sequence_nullness_or_absence denotes −
T17597 38137-38141 NCBITaxon:10088 denotes mice
T17598 38160-38164 GO_EXT:breeding denotes bred
T17599 38185-38189 NCBITaxon:10088 denotes mice
T17600 38206-38210 NCBITaxon:10088 denotes mice
T17601 38216-38222 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T17602 38228-38232 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T17603 38253-38257 NCBITaxon:10088 denotes mice
T17604 38263-38266 GO:0007631 denotes fed
T17605 38274-38278 CHEBI_EXT:33290 denotes Chow
T17606 38293-38296 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T17607 38371-38374 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T17608 38385-38396 CHEBI:16113 denotes cholesterol
T17609 38408-38412 NCBITaxon:10088 denotes Mice
T17610 38418-38428 GO_EXT:killing denotes sacrificed
T17611 38449-38454 GO:0016265 denotes death
T17612 38456-38462 UBERON:0002107 denotes livers
T17613 38517-38519 CHEBI:17997 denotes N2
T17614 38525-38541 UBERON:0003428 denotes gonadal fat pads
T17615 38533-38536 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T18332 38571-38574 CHEBI_SO_EXT:RNA denotes RNA
T18333 38606-38619 GO:0097617 denotes hybridization
T18334 38625-38635 GO:0010467 denotes expression
T18335 38646-38649 CHEBI_SO_EXT:RNA denotes RNA
T18336 38672-38686 GO:0097617 denotes hybridizations
T18337 38889-38895 CHEBI_SO_EXT:molecular_probe denotes probes
T18338 38918-38934 CHEBI_SO_EXT:oligonucleotide denotes oligonucleotides
T18339 38950-38955 NCBITaxon:10088 denotes mouse
T18340 38998-39007 SO_EXT:biological_sequence denotes sequences
T18341 39030-39036 SO_EXT:sequence_cloned_entity denotes clones
T18342 39038-39043 NCBITaxon:10088 denotes Mouse
T18343 39044-39050 UBERON:0002107 denotes livers
T18344 39078-39081 CHEBI_SO_EXT:RNA denotes RNA
T18345 39105-39112 CHEBI_EXT:33893 denotes reagent
T18346 39227-39230 CHEBI_SO_EXT:RNA denotes RNA
T18347 39235-39254 GO:0001171 denotes reverse transcribed
T18348 39259-39266 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeled
T18349 39279-39282 CHEBI:37987 denotes Cy3
T18350 39286-39289 CHEBI:37989 denotes Cy5
T18351 39290-39302 CHEBI_EXT:51217 denotes fluorochrome
T18352 39313-39316 CHEBI:37987 denotes Cy3
T18353 39320-39323 CHEBI:37989 denotes Cy5
T18354 39338-39341 CHEBI_SO_EXT:RNA denotes RNA
T18355 39346-39356 GO:0097617 denotes hybridized
T18356 39425-39438 GO:0097617 denotes hybridization
T18357 39748-39752 SO_EXT:0000704 denotes Gene
T18358 39748-39763 GO:0010467 denotes Gene expression
T18359 39829-39833 NCBITaxon:10088 denotes mice
T18360 40056-40060 SO_EXT:0000704 denotes gene
T18361 40093-40102 GO:0010467 denotes expressed
T21081 40311-40322 SO_EXT:genomic_DNA denotes Genomic DNA
T21082 40319-40322 CHEBI_SO_EXT:DNA denotes DNA
T21083 40341-40347 UBERON:0002113 denotes kidney
T21084 40351-40357 CHEBI:15882 denotes phenol
T21085 40358-40368 CHEBI:35255 denotes chloroform
T21086 40440-40444 SO_EXT:0000694 denotes SNPs
T21087 40457-40466 SO_EXT:sequence_variation_entity_or_quality denotes variation
T21088 40537-40546 GO:0030849 denotes autosomes
T21089 40584-40588 SO_EXT:0000694 denotes SNPs
T21090 40719-40728 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T21091 40739-40744 CHEBI_SO_EXT:molecular_probe denotes probe
T21092 40825-40829 SO_EXT:0000704 denotes gene
T21093 40825-40840 GO:0010467 denotes gene expression
T21094 40976-40980 SO_EXT:0000771 denotes QTLs
T21095 41248-41253 UBERON:0002107 denotes liver
T21096 41254-41265 SO_EXT:0000673 denotes transcripts
T21097 41276-41282 SO_EXT:0001026 denotes genome
T21098 41344-41348 SO_EXT:sequence_nullness denotes null
T21099 41658-41664 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T21100 41665-41673 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T21101 41756-41759 SO_EXT:0000771 denotes QTL
T21102 41788-41793 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T21103 41798-41805 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T21104 41957-41961 SO_EXT:sequence_nullness denotes null
T21105 42045-42048 SO_EXT:0000771 denotes QTL
T21106 42111-42114 SO_EXT:0000771 denotes QTL
T21107 42377-42381 SO_EXT:sequence_nullness denotes null
T21108 42560-42564 SO_EXT:0000771 denotes QTLs
T21109 42635-42642 NCBITaxon:33208 denotes animals
T21110 42738-42742 SO_EXT:0000771 denotes QTLs
T21111 42885-42889 SO_EXT:0000771 denotes QTLs
T21112 43145-43148 SO_EXT:0000771 denotes QTL
T21113 43300-43306 SO_EXT:0001026 denotes genome
T21114 43714-43717 SO_EXT:0000771 denotes QTL
T21115 44006-44012 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T21116 44584-44589 SO_EXT:0000704 denotes genes
T21117 44628-44633 SO_EXT:0000704 denotes genes
T21118 44646-44655 GO:0010467 denotes expressed
T23054 47190-47206 CHEBI_SO_EXT:oligonucleotide denotes oligonucleotides
T23055 47319-47326 UBERON:0000991 denotes gonadal
T23056 47327-47330 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T23057 47346-47356 SO_EXT:0000673 denotes transcript
T23058 47502-47506 SO_EXT:sequence_nullness denotes null
T23059 47654-47658 SO_EXT:0000704 denotes gene
T23060 47868-47872 SO_EXT:sequence_nullness denotes null
T23061 48031-48036 SO_EXT:0000704 denotes Genes
T23062 48057-48064 UBERON:0000991 denotes gonadal
T23063 48065-48068 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T23064 48167-48172 SO_EXT:0000704 denotes genes
T23065 48314-48319 UBERON:0002107 denotes liver
T23066 48362-48368 SO_EXT:0001026 denotes genome
T23067 48656-48662 SO_EXT:0001026 denotes genome
T23068 48786-48793 UBERON:0000991 denotes gonadal
T23069 48794-48797 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T21139 46203-46207 SO_EXT:0000771 denotes QTLs
T21140 46854-46864 GO:0010467 denotes expression
T10444 23676-23685 GO:0065007 denotes regulated
T21119 44663-44668 UBERON:0002107 denotes liver
T21120 44687-44691 SO_EXT:0000704 denotes gene
T21121 44705-44711 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T21122 44851-44855 SO_EXT:0000704 denotes gene
T21123 44851-44866 GO:0010467 denotes gene expression
T21124 44940-44945 SO_EXT:0000704 denotes genes
T21125 45054-45057 SO_EXT:0000771 denotes QTL
T21126 45164-45167 SO_EXT:0000771 denotes QTL
T21127 45199-45203 SO_EXT:0000704 denotes gene
T21128 45405-45408 SO_EXT:0000771 denotes QTL
T21129 45413-45423 GO_SO_EXT:chromosome denotes chromosome
T21130 45428-45432 SO_EXT:0000704 denotes gene
T21131 45428-45443 GO:0010467 denotes gene expression
T21132 45474-45477 SO_EXT:0000771 denotes QTL
T21133 45509-45519 GO_SO_EXT:chromosome denotes chromosome
T21134 45902-45906 SO_EXT:0000704 denotes gene
T21135 45902-45917 GO:0010467 denotes gene expression
T21136 45973-45977 SO_EXT:0000771 denotes QTLs
T21137 46012-46017 SO_EXT:0000704 denotes genes
T21138 46081-46085 SO_EXT:0000771 denotes QTLs
T21141 46884-46890 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T21142 47076-47079 SO_EXT:0000771 denotes QTL
R4769 T15730 T15729 _lexicallyChainedTo locus,Chromosome
R249 T1971 T1970 _lexicallyChainedTo gene expression,regulation of
R1858 T7340 T7339 _lexicallyChainedTo chromosome,regions on
R2794 T10478 T10477 _lexicallyChainedTo locus,Chromosome
R2795 T10484 T10483 _lexicallyChainedTo locus,Chromosome
R2796 T10508 T10507 _lexicallyChainedTo locus,Chromosome
R3816 T13671 T13670 _lexicallyChainedTo Gene Expression,Regulation of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T535 20-28 NN denotes Analysis
T536 0-104 sentence denotes Genetic and Genomic Analysis of a Fat Mass Trait with Complex Inheritance Reveals Marked Sex Specificity
T537 8-11 CC denotes and
T538 12-19 JJ denotes Genomic
T539 74-81 VBZ denotes Reveals
T540 29-31 IN denotes of
T541 32-33 DT denotes a
T542 43-48 NN denotes Trait
T543 34-37 NN denotes Fat
T544 38-42 NN denotes Mass
T545 49-53 IN denotes with
T546 54-61 JJ denotes Complex
T547 62-73 NN denotes Inheritance
T548 82-88 JJ denotes Marked
T549 93-104 NN denotes Specificity
T550 89-92 NN denotes Sex
T551 104-105 sentence denotes
T552 154-291 sentence denotes The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes.
T553 154-157 DT denotes The
T554 158-169 NN denotes integration
T555 238-242 VBN denotes used
T556 170-172 IN denotes of
T557 173-183 NN denotes expression
T558 184-193 NN denotes profiling
T559 194-198 IN denotes with
T560 199-206 NN denotes linkage
T561 207-215 NN denotes analysis
T562 216-219 VBZ denotes has
T563 220-232 RB denotes increasingly
T564 233-237 VBN denotes been
T565 243-245 TO denotes to
T566 246-254 VB denotes identify
T567 255-260 NNS denotes genes
T568 261-271 VBG denotes underlying
T569 272-279 JJ denotes complex
T570 280-290 NNS denotes phenotypes
T571 290-291 . denotes .
T572 291-501 sentence denotes The effects of gender on the regulation of many physiological traits are well documented; however, “genetical genomic” analyses have not yet addressed the degree to which their conclusions are affected by sex.
T573 292-295 DT denotes The
T574 296-303 NNS denotes effects
T575 361-364 VBP denotes are
T576 304-306 IN denotes of
T577 307-313 NN denotes gender
T578 314-316 IN denotes on
T579 317-320 DT denotes the
T580 321-331 NN denotes regulation
T581 332-334 IN denotes of
T582 335-339 JJ denotes many
T583 354-360 NNS denotes traits
T584 340-353 JJ denotes physiological
T585 433-442 VBN denotes addressed
T586 365-369 RB denotes well
T587 370-380 JJ denotes documented
T588 380-381 : denotes ;
T589 382-389 RB denotes however
T590 389-391 , denotes ,
T591 391-392 `` denotes “
T592 411-419 NNS denotes analyses
T593 392-401 JJ denotes genetical
T594 402-409 JJ denotes genomic
T595 409-410 '' denotes ”
T596 420-424 VBP denotes have
T597 425-428 RB denotes not
T598 429-432 RB denotes yet
T599 443-446 DT denotes the
T600 447-453 NN denotes degree
T601 454-456 IN denotes to
T602 485-493 VBN denotes affected
T603 457-462 WDT denotes which
T604 463-468 PRP$ denotes their
T605 469-480 NNS denotes conclusions
T606 481-484 VBP denotes are
T607 494-496 IN denotes by
T608 497-500 NN denotes sex
T609 500-501 . denotes .
T610 501-669 sentence denotes We constructed and densely genotyped a large F2 intercross derived from the inbred mouse strains C57BL/6J and C3H/HeJ on an apolipoprotein E null (ApoE−/−) background.
T611 502-504 PRP denotes We
T612 505-516 VBD denotes constructed
T613 517-520 CC denotes and
T614 521-528 RB denotes densely
T615 529-538 VBD denotes genotyped
T616 539-540 DT denotes a
T617 550-560 NN denotes intercross
T618 541-546 JJ denotes large
T619 547-549 NN denotes F2
T620 561-568 VBN denotes derived
T621 569-573 IN denotes from
T622 574-577 DT denotes the
T623 591-598 NNS denotes strains
T624 578-584 JJ denotes inbred
T625 585-590 NN denotes mouse
T626 599-604 NN denotes C57BL
T627 605-607 NN denotes 6J
T628 604-605 HYPH denotes /
T629 608-611 CC denotes and
T630 612-615 NN denotes C3H
T631 616-619 NN denotes HeJ
T632 615-616 HYPH denotes /
T633 620-622 IN denotes on
T634 623-625 DT denotes an
T635 658-668 NN denotes background
T636 626-640 NN denotes apolipoprotein
T637 641-642 NN denotes E
T638 643-647 JJ denotes null
T639 648-649 -LRB- denotes (
T640 649-653 NN denotes ApoE
T641 653-654 SYM denotes −
T642 654-655 HYPH denotes /
T643 655-656 SYM denotes −
T644 656-657 -RRB- denotes )
T645 668-669 . denotes .
T646 669-752 sentence denotes This BXH.ApoE−/− population recapitulates several “metabolic syndrome” phenotypes.
T647 670-674 DT denotes This
T648 687-697 NN denotes population
T649 675-683 NN denotes BXH.ApoE
T650 683-684 SYM denotes −
T651 684-685 HYPH denotes /
T652 685-686 SYM denotes −
T653 698-711 VBZ denotes recapitulates
T654 712-719 JJ denotes several
T655 741-751 NNS denotes phenotypes
T656 720-721 `` denotes “
T657 721-730 JJ denotes metabolic
T658 731-739 NN denotes syndrome
T659 739-740 '' denotes ”
T660 751-752 . denotes .
T661 752-872 sentence denotes The cross consists of 334 animals of both sexes, allowing us to specifically test for the dependence of linkage on sex.
T662 753-756 DT denotes The
T663 757-762 NN denotes cross
T664 763-771 VBZ denotes consists
T665 772-774 IN denotes of
T666 775-778 CD denotes 334
T667 779-786 NNS denotes animals
T668 787-789 IN denotes of
T669 790-794 DT denotes both
T670 795-800 NNS denotes sexes
T671 800-802 , denotes ,
T672 802-810 VBG denotes allowing
T673 811-813 PRP denotes us
T674 830-834 VB denotes test
T675 814-816 TO denotes to
T676 817-829 RB denotes specifically
T677 835-838 IN denotes for
T678 839-842 DT denotes the
T679 843-853 NN denotes dependence
T680 854-856 IN denotes of
T681 857-864 NN denotes linkage
T682 865-867 IN denotes on
T683 868-871 NN denotes sex
T684 871-872 . denotes .
T685 872-998 sentence denotes We detected several thousand liver gene expression quantitative trait loci, a significant proportion of which are sex-biased.
T686 873-875 PRP denotes We
T687 876-884 VBD denotes detected
T688 885-892 JJ denotes several
T689 893-901 CD denotes thousand
T690 943-947 NNS denotes loci
T691 902-907 NN denotes liver
T692 908-912 NN denotes gene
T693 913-923 NN denotes expression
T694 924-936 JJ denotes quantitative
T695 937-942 NN denotes trait
T696 947-949 , denotes ,
T697 949-950 DT denotes a
T698 963-973 NN denotes proportion
T699 951-962 JJ denotes significant
T700 983-986 VBP denotes are
T701 974-976 IN denotes of
T702 977-982 WDT denotes which
T703 987-990 NN denotes sex
T704 991-997 VBN denotes biased
T705 990-991 HYPH denotes -
T706 997-998 . denotes .
T707 998-1112 sentence denotes We used these analyses to dissect the genetics of gonadal fat mass, a complex trait with sex-specific regulation.
T708 999-1001 PRP denotes We
T709 1002-1006 VBD denotes used
T710 1007-1012 DT denotes these
T711 1013-1021 NNS denotes analyses
T712 1022-1024 TO denotes to
T713 1025-1032 VB denotes dissect
T714 1033-1036 DT denotes the
T715 1037-1045 NN denotes genetics
T716 1046-1048 IN denotes of
T717 1049-1056 JJ denotes gonadal
T718 1061-1065 NN denotes mass
T719 1057-1060 NN denotes fat
T720 1065-1067 , denotes ,
T721 1067-1068 DT denotes a
T722 1077-1082 NN denotes trait
T723 1069-1076 JJ denotes complex
T724 1083-1087 IN denotes with
T725 1088-1091 NN denotes sex
T726 1092-1100 JJ denotes specific
T727 1091-1092 HYPH denotes -
T728 1101-1111 NN denotes regulation
T729 1111-1112 . denotes .
T730 1112-1236 sentence denotes We present evidence for a remarkably high degree of sex-dependence on both the cis and trans regulation of gene expression.
T731 1113-1115 PRP denotes We
T732 1116-1123 VBP denotes present
T733 1124-1132 NN denotes evidence
T734 1133-1136 IN denotes for
T735 1137-1138 DT denotes a
T736 1155-1161 NN denotes degree
T737 1139-1149 RB denotes remarkably
T738 1150-1154 JJ denotes high
T739 1162-1164 IN denotes of
T740 1165-1168 NN denotes sex
T741 1169-1179 NN denotes dependence
T742 1168-1169 HYPH denotes -
T743 1180-1182 IN denotes on
T744 1183-1187 CC denotes both
T745 1192-1195 NN denotes cis
T746 1188-1191 DT denotes the
T747 1196-1199 CC denotes and
T748 1200-1205 NN denotes trans
T749 1206-1216 NN denotes regulation
T750 1217-1219 IN denotes of
T751 1220-1224 NN denotes gene
T752 1225-1235 NN denotes expression
T753 1235-1236 . denotes .
T754 1236-1409 sentence denotes We demonstrate how these analyses can be applied to the study of the genetics underlying gonadal fat mass, a complex trait showing significantly female-biased heritability.
T755 1237-1239 PRP denotes We
T756 1240-1251 VBP denotes demonstrate
T757 1252-1255 WRB denotes how
T758 1278-1285 VBN denotes applied
T759 1256-1261 DT denotes these
T760 1262-1270 NNS denotes analyses
T761 1271-1274 MD denotes can
T762 1275-1277 VB denotes be
T763 1286-1288 IN denotes to
T764 1289-1292 DT denotes the
T765 1293-1298 NN denotes study
T766 1299-1301 IN denotes of
T767 1302-1305 DT denotes the
T768 1306-1314 NN denotes genetics
T769 1315-1325 VBG denotes underlying
T770 1326-1333 JJ denotes gonadal
T771 1338-1342 NN denotes mass
T772 1334-1337 NN denotes fat
T773 1342-1344 , denotes ,
T774 1344-1345 DT denotes a
T775 1354-1359 NN denotes trait
T776 1346-1353 JJ denotes complex
T777 1360-1367 VBG denotes showing
T778 1368-1381 RB denotes significantly
T779 1389-1395 VBN denotes biased
T780 1382-1388 JJ denotes female
T781 1388-1389 HYPH denotes -
T782 1396-1408 NN denotes heritability
T783 1408-1409 . denotes .
T784 1409-1521 sentence denotes These data have implications on the potential effects of sex on the genetic regulation of other complex traits.
T785 1410-1415 DT denotes These
T786 1416-1420 NNS denotes data
T787 1421-1425 VBP denotes have
T788 1426-1438 NNS denotes implications
T789 1439-1441 IN denotes on
T790 1442-1445 DT denotes the
T791 1456-1463 NNS denotes effects
T792 1446-1455 JJ denotes potential
T793 1464-1466 IN denotes of
T794 1467-1470 NN denotes sex
T795 1471-1473 IN denotes on
T796 1474-1477 DT denotes the
T797 1486-1496 NN denotes regulation
T798 1478-1485 JJ denotes genetic
T799 1497-1499 IN denotes of
T800 1500-1505 JJ denotes other
T801 1514-1520 NNS denotes traits
T802 1506-1513 JJ denotes complex
T803 1520-1521 . denotes .
T1994 2836-2843 NNS denotes Females
T1995 2854-2859 VBP denotes share
T1996 2844-2847 CC denotes and
T1997 2848-2853 NNS denotes males
T1998 2860-2866 RB denotes nearly
T1999 2867-2876 JJ denotes identical
T2000 2885-2896 NN denotes information
T2001 2877-2884 JJ denotes genetic
T2002 2896-2898 , denotes ,
T2003 2898-2901 CC denotes but
T2004 2902-2906 VBP denotes vary
T2005 2907-2913 RB denotes widely
T2006 2914-2918 IN denotes with
T2007 2919-2926 NN denotes respect
T2008 2927-2929 IN denotes to
T2009 2930-2937 NN denotes disease
T2010 2938-2952 NN denotes susceptibility
T2011 2953-2954 -LRB- denotes [
T2012 2956-2957 CD denotes 2
T2013 2954-2955 CD denotes 1
T2014 2955-2956 , denotes ,
T2015 2957-2958 -RRB- denotes ]
T2016 2958-2959 . denotes .
T2017 2959-3268 sentence denotes Apart from the obvious gender-specific diseases such as cervical or prostate cancer, sex influences susceptibility to nearly all highly prevalent diseases that affect both women and men, including atherosclerosis and diabetes and their precursor conditions of hyperlipidemia, obesity, and insulin resistance.
T2018 2960-2965 RB denotes Apart
T2019 3049-3059 VBZ denotes influences
T2020 2966-2970 IN denotes from
T2021 2971-2974 DT denotes the
T2022 2999-3007 NNS denotes diseases
T2023 2975-2982 JJ denotes obvious
T2024 2983-2989 NN denotes gender
T2025 2990-2998 JJ denotes specific
T2026 2989-2990 HYPH denotes -
T2027 3008-3012 JJ denotes such
T2028 3013-3015 IN denotes as
T2029 3016-3024 JJ denotes cervical
T2030 3037-3043 NN denotes cancer
T2031 3025-3027 CC denotes or
T2032 3028-3036 NN denotes prostate
T2033 3043-3045 , denotes ,
T2034 3045-3048 NN denotes sex
T2035 3060-3074 NN denotes susceptibility
T2036 3075-3077 IN denotes to
T2037 3078-3084 RB denotes nearly
T2038 3085-3088 DT denotes all
T2039 3106-3114 NNS denotes diseases
T2040 3089-3095 RB denotes highly
T2041 3096-3105 JJ denotes prevalent
T2042 3115-3119 WDT denotes that
T2043 3120-3126 VBP denotes affect
T2044 3127-3131 DT denotes both
T2045 3132-3137 NNS denotes women
T2046 3138-3141 CC denotes and
T2047 3142-3145 NNS denotes men
T2048 3145-3147 , denotes ,
T2049 3147-3156 VBG denotes including
T2050 3157-3172 NN denotes atherosclerosis
T2051 3173-3176 CC denotes and
T2052 3177-3185 NN denotes diabetes
T2053 3186-3189 CC denotes and
T2054 3190-3195 PRP$ denotes their
T2055 3206-3216 NNS denotes conditions
T2056 3196-3205 NN denotes precursor
T2057 3217-3219 IN denotes of
T2058 3220-3234 NN denotes hyperlipidemia
T2059 3234-3236 , denotes ,
T2060 3236-3243 NN denotes obesity
T2061 3243-3245 , denotes ,
T2062 3245-3248 CC denotes and
T2063 3249-3256 NN denotes insulin
T2064 3257-3267 NN denotes resistance
T2065 3267-3268 . denotes .
T2066 3268-3452 sentence denotes These are multifactorial in their pathogenesis, encompassing environmental and behavioral aspects, as well as significant genetic determination, on which these other factors interact.
T2067 3269-3274 DT denotes These
T2068 3275-3278 VBP denotes are
T2069 3279-3293 JJ denotes multifactorial
T2070 3294-3296 IN denotes in
T2071 3297-3302 PRP$ denotes their
T2072 3303-3315 NN denotes pathogenesis
T2073 3315-3317 , denotes ,
T2074 3317-3329 VBG denotes encompassing
T2075 3330-3343 JJ denotes environmental
T2076 3359-3366 NNS denotes aspects
T2077 3344-3347 CC denotes and
T2078 3348-3358 JJ denotes behavioral
T2079 3366-3368 , denotes ,
T2080 3368-3370 RB denotes as
T2081 3376-3378 IN denotes as
T2082 3371-3375 RB denotes well
T2083 3379-3390 JJ denotes significant
T2084 3399-3412 NN denotes determination
T2085 3391-3398 JJ denotes genetic
T2086 3412-3414 , denotes ,
T2087 3414-3416 IN denotes on
T2088 3443-3451 VBP denotes interact
T2089 3417-3422 WDT denotes which
T2090 3423-3428 DT denotes these
T2091 3435-3442 NNS denotes factors
T2092 3429-3434 JJ denotes other
T2093 3451-3452 . denotes .
T2094 3452-3574 sentence denotes The genetic component is multigenic, with the heritability embedded in the genetic variation intrinsic to our population.
T2095 3453-3456 DT denotes The
T2096 3465-3474 NN denotes component
T2097 3457-3464 JJ denotes genetic
T2098 3475-3477 VBZ denotes is
T2099 3478-3488 JJ denotes multigenic
T2100 3488-3490 , denotes ,
T2101 3490-3494 IN denotes with
T2102 3495-3498 DT denotes the
T2103 3499-3511 NN denotes heritability
T2104 3512-3520 VBN denotes embedded
T2105 3521-3523 IN denotes in
T2106 3524-3527 DT denotes the
T2107 3536-3545 NN denotes variation
T2108 3528-3535 JJ denotes genetic
T2109 3546-3555 JJ denotes intrinsic
T2110 3556-3558 IN denotes to
T2111 3559-3562 PRP$ denotes our
T2112 3563-3573 NN denotes population
T2113 3573-3574 . denotes .
T2114 3574-3757 sentence denotes Although the sex differences in disease susceptibility are recognized, the interplay between sex and gene expression that is at the basis of these differences is not well understood.
T2115 3575-3583 IN denotes Although
T2116 3634-3644 VBN denotes recognized
T2117 3584-3587 DT denotes the
T2118 3592-3603 NNS denotes differences
T2119 3588-3591 NN denotes sex
T2120 3604-3606 IN denotes in
T2121 3607-3614 NN denotes disease
T2122 3615-3629 NN denotes susceptibility
T2123 3630-3633 VBP denotes are
T2124 3734-3736 VBZ denotes is
T2125 3644-3646 , denotes ,
T2126 3646-3649 DT denotes the
T2127 3650-3659 NN denotes interplay
T2128 3660-3667 IN denotes between
T2129 3668-3671 NN denotes sex
T2130 3672-3675 CC denotes and
T2131 3676-3680 NN denotes gene
T2132 3681-3691 NN denotes expression
T2133 3692-3696 WDT denotes that
T2134 3697-3699 VBZ denotes is
T2135 3700-3702 IN denotes at
T2136 3703-3706 DT denotes the
T2137 3707-3712 NN denotes basis
T2138 3713-3715 IN denotes of
T2139 3716-3721 DT denotes these
T2140 3722-3733 NNS denotes differences
T2141 3737-3740 RB denotes not
T2142 3741-3745 RB denotes well
T2143 3746-3756 JJ denotes understood
T2144 3756-3757 . denotes .
T2145 3757-3907 sentence denotes Females and males inherit (on average) the same genes that may be risk factors, but their expression and effect on disease risk varies significantly.
T2146 3758-3765 NNS denotes Females
T2147 3776-3783 VBP denotes inherit
T2148 3766-3769 CC denotes and
T2149 3770-3775 NNS denotes males
T2150 3784-3785 -LRB- denotes (
T2151 3785-3787 IN denotes on
T2152 3788-3795 JJ denotes average
T2153 3795-3796 -RRB- denotes )
T2154 3797-3800 DT denotes the
T2155 3806-3811 NNS denotes genes
T2156 3801-3805 JJ denotes same
T2157 3812-3816 WDT denotes that
T2158 3821-3823 VB denotes be
T2159 3817-3820 MD denotes may
T2160 3824-3828 NN denotes risk
T2161 3829-3836 NNS denotes factors
T2162 3836-3838 , denotes ,
T2163 3838-3841 CC denotes but
T2164 3842-3847 PRP$ denotes their
T2165 3848-3858 NN denotes expression
T2166 3886-3892 VBZ denotes varies
T2167 3859-3862 CC denotes and
T2168 3863-3869 NN denotes effect
T2169 3870-3872 IN denotes on
T2170 3873-3880 NN denotes disease
T2171 3881-3885 NN denotes risk
T2172 3893-3906 RB denotes significantly
T2173 3906-3907 . denotes .
T2174 3907-4083 sentence denotes An understanding and recognition of the significance of specific disease-associated polymorphisms/mutations in the context of sex is therefore of critical clinical importance.
T2175 3908-3910 DT denotes An
T2176 3911-3924 NN denotes understanding
T2177 4038-4040 VBZ denotes is
T2178 3925-3928 CC denotes and
T2179 3929-3940 NN denotes recognition
T2180 3941-3943 IN denotes of
T2181 3944-3947 DT denotes the
T2182 3948-3960 NN denotes significance
T2183 3961-3963 IN denotes of
T2184 3964-3972 JJ denotes specific
T2185 4006-4015 NNS denotes mutations
T2186 3973-3980 NN denotes disease
T2187 3981-3991 VBN denotes associated
T2188 3980-3981 HYPH denotes -
T2189 3992-4005 NNS denotes polymorphisms
T2190 4005-4006 HYPH denotes /
T2191 4016-4018 IN denotes in
T2192 4019-4022 DT denotes the
T2193 4023-4030 NN denotes context
T2194 4031-4033 IN denotes of
T2195 4034-4037 NN denotes sex
T2196 4041-4050 RB denotes therefore
T2197 4051-4053 IN denotes of
T2198 4054-4062 JJ denotes critical
T2199 4072-4082 NN denotes importance
T2200 4063-4071 JJ denotes clinical
T2201 4082-4083 . denotes .
T2202 4083-4192 sentence denotes We have utilized the mouse as a model system to study the genetics of metabolic and vascular diseases [3–5].
T2203 4084-4086 PRP denotes We
T2204 4092-4100 VBN denotes utilized
T2205 4087-4091 VBP denotes have
T2206 4101-4104 DT denotes the
T2207 4105-4110 NN denotes mouse
T2208 4111-4113 IN denotes as
T2209 4114-4115 DT denotes a
T2210 4122-4128 NN denotes system
T2211 4116-4121 NN denotes model
T2212 4129-4131 TO denotes to
T2213 4132-4137 VB denotes study
T2214 4138-4141 DT denotes the
T2215 4142-4150 NN denotes genetics
T2216 4151-4153 IN denotes of
T2217 4154-4163 JJ denotes metabolic
T2218 4177-4185 NNS denotes diseases
T2219 4164-4167 CC denotes and
T2220 4168-4176 JJ denotes vascular
T2221 4186-4187 -LRB- denotes [
T2222 4187-4188 CD denotes 3
T2223 4188-4189 SYM denotes –
T2224 4189-4190 CD denotes 5
T2225 4190-4191 -RRB- denotes ]
T2226 4191-4192 . denotes .
T2227 4192-4469 sentence denotes Rather than focus initially on natural or induced mutants of single genes, we utilize the complex endogenous genetic variation between strains in genetic crosses to identify causative genetic loci and ultimately the underlying variations responsible for trait differences [6].
T2228 4193-4199 RB denotes Rather
T2229 4271-4278 VBP denotes utilize
T2230 4200-4204 IN denotes than
T2231 4205-4210 VBP denotes focus
T2232 4211-4220 RB denotes initially
T2233 4221-4223 IN denotes on
T2234 4224-4231 JJ denotes natural
T2235 4243-4250 NNS denotes mutants
T2236 4232-4234 CC denotes or
T2237 4235-4242 VBN denotes induced
T2238 4251-4253 IN denotes of
T2239 4254-4260 JJ denotes single
T2240 4261-4266 NNS denotes genes
T2241 4266-4268 , denotes ,
T2242 4268-4270 PRP denotes we
T2243 4279-4282 DT denotes the
T2244 4310-4319 NN denotes variation
T2245 4283-4290 JJ denotes complex
T2246 4291-4301 JJ denotes endogenous
T2247 4302-4309 JJ denotes genetic
T2248 4320-4327 IN denotes between
T2249 4328-4335 NNS denotes strains
T2250 4336-4338 IN denotes in
T2251 4339-4346 JJ denotes genetic
T2252 4347-4354 NNS denotes crosses
T2253 4355-4357 TO denotes to
T2254 4358-4366 VB denotes identify
T2255 4367-4376 JJ denotes causative
T2256 4385-4389 NNS denotes loci
T2257 4377-4384 JJ denotes genetic
T2258 4390-4393 CC denotes and
T2259 4394-4404 RB denotes ultimately
T2260 4420-4430 NNS denotes variations
T2261 4405-4408 DT denotes the
T2262 4409-4419 VBG denotes underlying
T2263 4431-4442 JJ denotes responsible
T2264 4443-4446 IN denotes for
T2265 4447-4452 NN denotes trait
T2266 4453-4464 NNS denotes differences
T2267 4465-4466 -LRB- denotes [
T2268 4466-4467 CD denotes 6
T2269 4467-4468 -RRB- denotes ]
T2270 4468-4469 . denotes .
T2271 4469-4556 sentence denotes This design more closely reflects the situation faced when studying human populations.
T2272 4470-4474 DT denotes This
T2273 4475-4481 NN denotes design
T2274 4495-4503 VBZ denotes reflects
T2275 4482-4486 RBR denotes more
T2276 4487-4494 RB denotes closely
T2277 4504-4507 DT denotes the
T2278 4508-4517 NN denotes situation
T2279 4518-4523 VBN denotes faced
T2280 4524-4528 WRB denotes when
T2281 4529-4537 VBG denotes studying
T2282 4538-4543 JJ denotes human
T2283 4544-4555 NNS denotes populations
T2284 4555-4556 . denotes .
T2285 4556-4704 sentence denotes The genetic composition of each individual mouse is restricted to that of the two parental strains and is defined at every locus across the genome.
T2286 4557-4560 DT denotes The
T2287 4569-4580 NN denotes composition
T2288 4561-4568 JJ denotes genetic
T2289 4609-4619 VBN denotes restricted
T2290 4581-4583 IN denotes of
T2291 4584-4588 DT denotes each
T2292 4600-4605 NN denotes mouse
T2293 4589-4599 JJ denotes individual
T2294 4606-4608 VBZ denotes is
T2295 4620-4622 IN denotes to
T2296 4623-4627 DT denotes that
T2297 4628-4630 IN denotes of
T2298 4631-4634 DT denotes the
T2299 4648-4655 NNS denotes strains
T2300 4635-4638 CD denotes two
T2301 4639-4647 JJ denotes parental
T2302 4656-4659 CC denotes and
T2303 4660-4662 VBZ denotes is
T2304 4663-4670 VBN denotes defined
T2305 4671-4673 IN denotes at
T2306 4674-4679 DT denotes every
T2307 4680-4685 NN denotes locus
T2308 4686-4692 IN denotes across
T2309 4693-4696 DT denotes the
T2310 4697-4703 NN denotes genome
T2311 4703-4704 . denotes .
T2312 4704-4930 sentence denotes The application of quantitative trait locus (QTL) analysis allows the identification of those chromosomal regions that contain a genetic variation that influences trait expression (for a comprehensive review on QTLs see [7]).
T2313 4705-4708 DT denotes The
T2314 4709-4720 NN denotes application
T2315 4764-4770 VBZ denotes allows
T2316 4721-4723 IN denotes of
T2317 4724-4736 JJ denotes quantitative
T2318 4737-4742 NN denotes trait
T2319 4743-4748 NN denotes locus
T2320 4755-4763 NN denotes analysis
T2321 4749-4750 -LRB- denotes (
T2322 4750-4753 NN denotes QTL
T2323 4753-4754 -RRB- denotes )
T2324 4771-4774 DT denotes the
T2325 4775-4789 NN denotes identification
T2326 4790-4792 IN denotes of
T2327 4793-4798 DT denotes those
T2328 4811-4818 NNS denotes regions
T2329 4799-4810 JJ denotes chromosomal
T2330 4819-4823 WDT denotes that
T2331 4824-4831 VBP denotes contain
T2332 4832-4833 DT denotes a
T2333 4842-4851 NN denotes variation
T2334 4834-4841 JJ denotes genetic
T2335 4852-4856 WDT denotes that
T2336 4857-4867 VBZ denotes influences
T2337 4868-4873 NN denotes trait
T2338 4874-4884 NN denotes expression
T2339 4885-4886 -LRB- denotes (
T2340 4921-4924 VBP denotes see
T2341 4886-4889 IN denotes for
T2342 4890-4891 DT denotes a
T2343 4906-4912 NN denotes review
T2344 4892-4905 JJ denotes comprehensive
T2345 4913-4915 IN denotes on
T2346 4916-4920 NNS denotes QTLs
T2347 4925-4926 -LRB- denotes [
T2348 4926-4927 CD denotes 7
T2349 4927-4928 -RRB- denotes ]
T2350 4928-4929 -RRB- denotes )
T2351 4929-4930 . denotes .
T2352 4930-5152 sentence denotes We [5,8], and others [9–17], have recently extended the power of this approach by incorporating genome-wide gene expression array analysis, which allows us to model the “genetics of gene expression” using similar methods.
T2353 4931-4933 PRP denotes We
T2354 4974-4982 VBN denotes extended
T2355 4934-4935 -LRB- denotes [
T2356 4937-4938 CD denotes 8
T2357 4935-4936 CD denotes 5
T2358 4936-4937 , denotes ,
T2359 4938-4939 -RRB- denotes ]
T2360 4939-4941 , denotes ,
T2361 4941-4944 CC denotes and
T2362 4945-4951 NNS denotes others
T2363 4952-4953 -LRB- denotes [
T2364 4953-4954 CD denotes 9
T2365 4954-4955 SYM denotes –
T2366 4955-4957 CD denotes 17
T2367 4957-4958 -RRB- denotes ]
T2368 4958-4960 , denotes ,
T2369 4960-4964 VBP denotes have
T2370 4965-4973 RB denotes recently
T2371 4983-4986 DT denotes the
T2372 4987-4992 NN denotes power
T2373 4993-4995 IN denotes of
T2374 4996-5000 DT denotes this
T2375 5001-5009 NN denotes approach
T2376 5010-5012 IN denotes by
T2377 5013-5026 VBG denotes incorporating
T2378 5027-5033 NN denotes genome
T2379 5034-5038 JJ denotes wide
T2380 5033-5034 HYPH denotes -
T2381 5061-5069 NN denotes analysis
T2382 5039-5043 NN denotes gene
T2383 5044-5054 NN denotes expression
T2384 5055-5060 NN denotes array
T2385 5069-5071 , denotes ,
T2386 5071-5076 WDT denotes which
T2387 5077-5083 VBZ denotes allows
T2388 5084-5086 PRP denotes us
T2389 5090-5095 VB denotes model
T2390 5087-5089 TO denotes to
T2391 5096-5099 DT denotes the
T2392 5101-5109 NN denotes genetics
T2393 5100-5101 `` denotes “
T2394 5110-5112 IN denotes of
T2395 5113-5117 NN denotes gene
T2396 5118-5128 NN denotes expression
T2397 5128-5129 '' denotes ”
T2398 5130-5135 VBG denotes using
T2399 5136-5143 JJ denotes similar
T2400 5144-5151 NNS denotes methods
T2401 5151-5152 . denotes .
T2402 5152-5343 sentence denotes An immediate extension of this approach is toward dissecting the genetic regulation of complex phenotypes, which would greatly improve the progression from candidate locus to candidate gene.
T2403 5153-5155 DT denotes An
T2404 5166-5175 NN denotes extension
T2405 5156-5165 JJ denotes immediate
T2406 5193-5195 VBZ denotes is
T2407 5176-5178 IN denotes of
T2408 5179-5183 DT denotes this
T2409 5184-5192 NN denotes approach
T2410 5196-5202 IN denotes toward
T2411 5203-5213 VBG denotes dissecting
T2412 5214-5217 DT denotes the
T2413 5226-5236 NN denotes regulation
T2414 5218-5225 JJ denotes genetic
T2415 5237-5239 IN denotes of
T2416 5240-5247 JJ denotes complex
T2417 5248-5258 NNS denotes phenotypes
T2418 5258-5260 , denotes ,
T2419 5260-5265 WDT denotes which
T2420 5280-5287 VB denotes improve
T2421 5266-5271 MD denotes would
T2422 5272-5279 RB denotes greatly
T2423 5288-5291 DT denotes the
T2424 5292-5303 NN denotes progression
T2425 5304-5308 IN denotes from
T2426 5309-5318 NN denotes candidate
T2427 5319-5324 NN denotes locus
T2428 5325-5327 IN denotes to
T2429 5328-5337 NN denotes candidate
T2430 5338-5342 NN denotes gene
T2431 5342-5343 . denotes .
T2432 5343-5663 sentence denotes Here we report the application of this integrated approach to study the significance of sex on the genetic determinants of obesity and the associated regulation of liver gene expression in an F2 intercross derived from the inbred strains C57BL/6J (B6) and C3H/HeJ (C3H) on an apolipoprotein E null (ApoE−/−) background.
T2433 5344-5348 RB denotes Here
T2434 5352-5358 VBP denotes report
T2435 5349-5351 PRP denotes we
T2436 5359-5362 DT denotes the
T2437 5363-5374 NN denotes application
T2438 5375-5377 IN denotes of
T2439 5378-5382 DT denotes this
T2440 5394-5402 NN denotes approach
T2441 5383-5393 VBN denotes integrated
T2442 5403-5405 TO denotes to
T2443 5406-5411 VB denotes study
T2444 5412-5415 DT denotes the
T2445 5416-5428 NN denotes significance
T2446 5429-5431 IN denotes of
T2447 5432-5435 NN denotes sex
T2448 5436-5438 IN denotes on
T2449 5439-5442 DT denotes the
T2450 5451-5463 NNS denotes determinants
T2451 5443-5450 JJ denotes genetic
T2452 5464-5466 IN denotes of
T2453 5467-5474 NN denotes obesity
T2454 5475-5478 CC denotes and
T2455 5479-5482 DT denotes the
T2456 5494-5504 NN denotes regulation
T2457 5483-5493 VBN denotes associated
T2458 5505-5507 IN denotes of
T2459 5508-5513 NN denotes liver
T2460 5519-5529 NN denotes expression
T2461 5514-5518 NN denotes gene
T2462 5530-5532 IN denotes in
T2463 5533-5535 DT denotes an
T2464 5539-5549 NN denotes intercross
T2465 5536-5538 NN denotes F2
T2466 5550-5557 VBN denotes derived
T2467 5558-5562 IN denotes from
T2468 5563-5566 DT denotes the
T2469 5574-5581 NNS denotes strains
T2470 5567-5573 JJ denotes inbred
T2471 5582-5587 NN denotes C57BL
T2472 5588-5590 NN denotes 6J
T2473 5587-5588 HYPH denotes /
T2474 5591-5592 -LRB- denotes (
T2475 5592-5594 NN denotes B6
T2476 5594-5595 -RRB- denotes )
T2477 5596-5599 CC denotes and
T2478 5600-5603 NN denotes C3H
T2479 5604-5607 NN denotes HeJ
T2480 5603-5604 HYPH denotes /
T2481 5608-5609 -LRB- denotes (
T2482 5609-5612 NN denotes C3H
T2483 5612-5613 -RRB- denotes )
T2484 5614-5616 IN denotes on
T2485 5617-5619 DT denotes an
T2486 5652-5662 NN denotes background
T2487 5620-5634 NN denotes apolipoprotein
T2488 5635-5636 NN denotes E
T2489 5637-5641 JJ denotes null
T2490 5642-5643 -LRB- denotes (
T2491 5643-5647 NN denotes ApoE
T2492 5647-5648 SYM denotes −
T2493 5648-5649 HYPH denotes /
T2494 5649-5650 SYM denotes −
T2495 5650-5651 -RRB- denotes )
T2496 5662-5663 . denotes .
T2497 5663-5795 sentence denotes The BXH.ApoE−/− population was designed to recapitulate several of the phenotypes associated with the so-called metabolic syndrome.
T2498 5664-5667 DT denotes The
T2499 5680-5690 NN denotes population
T2500 5668-5676 NN denotes BXH.ApoE
T2501 5676-5677 SYM denotes −
T2502 5677-5678 HYPH denotes /
T2503 5678-5679 SYM denotes −
T2504 5695-5703 VBN denotes designed
T2505 5691-5694 VBD denotes was
T2506 5704-5706 TO denotes to
T2507 5707-5719 VB denotes recapitulate
T2508 5720-5727 JJ denotes several
T2509 5728-5730 IN denotes of
T2510 5731-5734 DT denotes the
T2511 5735-5745 NNS denotes phenotypes
T2512 5746-5756 VBN denotes associated
T2513 5757-5761 IN denotes with
T2514 5762-5765 DT denotes the
T2515 5786-5794 NN denotes syndrome
T2516 5766-5768 RB denotes so
T2517 5769-5775 VBN denotes called
T2518 5768-5769 HYPH denotes -
T2519 5776-5785 JJ denotes metabolic
T2520 5794-5795 . denotes .
T2521 5795-5912 sentence denotes The cross consists of 334 animals of both sexes, allowing us to specifically test for the dependence of QTLs on sex.
T2522 5796-5799 DT denotes The
T2523 5800-5805 NN denotes cross
T2524 5806-5814 VBZ denotes consists
T2525 5815-5817 IN denotes of
T2526 5818-5821 CD denotes 334
T2527 5822-5829 NNS denotes animals
T2528 5830-5832 IN denotes of
T2529 5833-5837 DT denotes both
T2530 5838-5843 NNS denotes sexes
T2531 5843-5845 , denotes ,
T2532 5845-5853 VBG denotes allowing
T2533 5854-5856 PRP denotes us
T2534 5873-5877 VB denotes test
T2535 5857-5859 TO denotes to
T2536 5860-5872 RB denotes specifically
T2537 5878-5881 IN denotes for
T2538 5882-5885 DT denotes the
T2539 5886-5896 NN denotes dependence
T2540 5897-5899 IN denotes of
T2541 5900-5904 NNS denotes QTLs
T2542 5905-5907 IN denotes on
T2543 5908-5911 NN denotes sex
T2544 5911-5912 . denotes .
T2545 5912-6022 sentence denotes We detected several thousand gene expression QTLs (eQTLs), a significant proportion of which were sex-biased.
T2546 5913-5915 PRP denotes We
T2547 5916-5924 VBD denotes detected
T2548 5925-5932 JJ denotes several
T2549 5933-5941 CD denotes thousand
T2550 5958-5962 NNS denotes QTLs
T2551 5942-5946 NN denotes gene
T2552 5947-5957 NN denotes expression
T2553 5963-5964 -LRB- denotes (
T2554 5964-5969 NNS denotes eQTLs
T2555 5969-5970 -RRB- denotes )
T2556 5970-5972 , denotes ,
T2557 5972-5973 DT denotes a
T2558 5986-5996 NN denotes proportion
T2559 5974-5985 JJ denotes significant
T2560 6006-6010 VBD denotes were
T2561 5997-5999 IN denotes of
T2562 6000-6005 WDT denotes which
T2563 6011-6014 NN denotes sex
T2564 6015-6021 VBN denotes biased
T2565 6014-6015 HYPH denotes -
T2566 6021-6022 . denotes .
T2567 6022-6158 sentence denotes We used these analyses to dissect the genetic regulation of the gonadal fat mass trait and to identify genes associated with the trait.
T2568 6023-6025 PRP denotes We
T2569 6026-6030 VBD denotes used
T2570 6031-6036 DT denotes these
T2571 6037-6045 NNS denotes analyses
T2572 6046-6048 TO denotes to
T2573 6049-6056 VB denotes dissect
T2574 6057-6060 DT denotes the
T2575 6069-6079 NN denotes regulation
T2576 6061-6068 JJ denotes genetic
T2577 6080-6082 IN denotes of
T2578 6083-6086 DT denotes the
T2579 6104-6109 NN denotes trait
T2580 6087-6094 JJ denotes gonadal
T2581 6099-6103 NN denotes mass
T2582 6095-6098 NN denotes fat
T2583 6110-6113 CC denotes and
T2584 6114-6116 TO denotes to
T2585 6117-6125 VB denotes identify
T2586 6126-6131 NNS denotes genes
T2587 6132-6142 VBN denotes associated
T2588 6143-6147 IN denotes with
T2589 6148-6151 DT denotes the
T2590 6152-6157 NN denotes trait
T2591 6157-6158 . denotes .
T4645 6202-6206 NN denotes Mass
T4641 6169-6173 NNS denotes QTLs
T4642 6174-6184 VBN denotes Associated
T4643 6185-6189 IN denotes with
T4644 6190-6197 JJ denotes Gonadal
T4646 6198-6201 NN denotes Fat
T4647 6206-6343 sentence denotes Characteristics of the B6.ApoE−/− and C3H.ApoE−/− parents and the F2 BXH.ApoE−/− generation on a Western diet are summarized in Table 1.
T4648 6207-6222 NNS denotes Characteristics
T4649 6321-6331 VBN denotes summarized
T4650 6223-6225 IN denotes of
T4651 6226-6229 DT denotes the
T4652 6257-6264 NNS denotes parents
T4653 6230-6237 NN denotes B6.ApoE
T4654 6237-6238 SYM denotes −
T4655 6238-6239 HYPH denotes /
T4656 6239-6240 SYM denotes −
T4657 6241-6244 CC denotes and
T4658 6245-6253 NN denotes C3H.ApoE
T4659 6253-6254 SYM denotes −
T4660 6254-6255 HYPH denotes /
T4661 6255-6256 SYM denotes −
T4662 6265-6268 CC denotes and
T4663 6269-6272 DT denotes the
T4664 6288-6298 NN denotes generation
T4665 6273-6275 NN denotes F2
T4666 6276-6284 NN denotes BXH.ApoE
T4667 6284-6285 SYM denotes −
T4668 6285-6286 HYPH denotes /
T4669 6286-6287 SYM denotes −
T4670 6299-6301 IN denotes on
T4671 6302-6303 DT denotes a
T4672 6312-6316 NN denotes diet
T4673 6304-6311 NNP denotes Western
T4674 6317-6320 VBP denotes are
T4675 6332-6334 IN denotes in
T4676 6335-6340 NN denotes Table
T4677 6341-6342 CD denotes 1
T4678 6342-6343 . denotes .
T4679 6343-6490 sentence denotes Gonadal fat mass differed significantly between the sexes in F2 (p < 10−4) and in the parental C3H.ApoE−/− (p < 0.05), but not in B6.ApoE−/− mice.
T4680 6344-6351 JJ denotes Gonadal
T4681 6356-6360 NN denotes mass
T4682 6352-6355 NN denotes fat
T4683 6361-6369 VBD denotes differed
T4684 6370-6383 RB denotes significantly
T4685 6384-6391 IN denotes between
T4686 6392-6395 DT denotes the
T4687 6396-6401 NNS denotes sexes
T4688 6402-6404 IN denotes in
T4689 6405-6407 NN denotes F2
T4690 6408-6409 -LRB- denotes (
T4691 6416-6417 CD denotes 4
T4692 6409-6410 NN denotes p
T4693 6411-6412 SYM denotes <
T4694 6413-6415 CD denotes 10
T4695 6415-6416 SYM denotes −
T4696 6417-6418 -RRB- denotes )
T4697 6419-6422 CC denotes and
T4698 6423-6425 IN denotes in
T4699 6426-6429 DT denotes the
T4700 6439-6447 NN denotes C3H.ApoE
T4701 6430-6438 JJ denotes parental
T4702 6447-6448 SYM denotes −
T4703 6448-6449 HYPH denotes /
T4704 6449-6450 SYM denotes −
T4705 6451-6452 -LRB- denotes (
T4706 6456-6460 CD denotes 0.05
T4707 6452-6453 NN denotes p
T4708 6454-6455 SYM denotes <
T4709 6460-6461 -RRB- denotes )
T4710 6461-6463 , denotes ,
T4711 6463-6466 CC denotes but
T4712 6467-6470 RB denotes not
T4713 6471-6473 IN denotes in
T4714 6474-6481 NN denotes B6.ApoE
T4715 6485-6489 NNS denotes mice
T4716 6481-6482 SYM denotes −
T4717 6482-6483 HYPH denotes /
T4718 6483-6484 SYM denotes −
T4719 6489-6490 . denotes .
T4720 6490-6644 sentence denotes Gonadal fat mass was the fat pad collection that represented the most animals and the most accurate collections and was thus chosen for further analysis.
T4721 6491-6498 JJ denotes Gonadal
T4722 6503-6507 NN denotes mass
T4723 6499-6502 NN denotes fat
T4724 6508-6511 VBD denotes was
T4725 6512-6515 DT denotes the
T4726 6524-6534 NN denotes collection
T4727 6516-6519 NN denotes fat
T4728 6520-6523 NN denotes pad
T4729 6535-6539 WDT denotes that
T4730 6540-6551 VBD denotes represented
T4731 6552-6555 DT denotes the
T4732 6561-6568 NNS denotes animals
T4733 6556-6560 JJS denotes most
T4734 6569-6572 CC denotes and
T4735 6573-6576 DT denotes the
T4736 6591-6602 NNS denotes collections
T4737 6577-6581 RBS denotes most
T4738 6582-6590 JJ denotes accurate
T4739 6603-6606 CC denotes and
T4740 6607-6610 VBD denotes was
T4741 6616-6622 VBN denotes chosen
T4742 6611-6615 RB denotes thus
T4743 6623-6626 IN denotes for
T4744 6627-6634 JJ denotes further
T4745 6635-6643 NN denotes analysis
T4746 6643-6644 . denotes .
T4747 6644-6914 sentence denotes Broad sense heritability (h 2) calculated as (σ2 Total − σ2 Parental)/σ2 Total for the gonadal fat mass trait was 54% for females and 36% for males, which is in close agreement with previous reports [18,19] and demonstrates significant heritability of gonadal fat mass.
T4748 6645-6650 JJ denotes Broad
T4749 6651-6656 NN denotes sense
T4750 6657-6669 NN denotes heritability
T4751 6755-6758 VBD denotes was
T4752 6670-6671 -LRB- denotes (
T4753 6671-6674 NN denotes h 2
T4754 6674-6675 -RRB- denotes )
T4755 6676-6686 VBN denotes calculated
T4756 6687-6689 IN denotes as
T4757 6690-6691 -LRB- denotes (
T4758 6691-6699 NN denotes σ2 Total
T4759 6702-6713 NN denotes σ2 Parental
T4760 6700-6701 SYM denotes −
T4761 6713-6714 -RRB- denotes )
T4762 6714-6715 HYPH denotes /
T4763 6715-6723 NN denotes σ2 Total
T4764 6724-6727 IN denotes for
T4765 6728-6731 DT denotes the
T4766 6749-6754 NN denotes trait
T4767 6732-6739 JJ denotes gonadal
T4768 6744-6748 NN denotes mass
T4769 6740-6743 NN denotes fat
T4770 6759-6761 CD denotes 54
T4771 6761-6762 NN denotes %
T4772 6763-6766 IN denotes for
T4773 6767-6774 NNS denotes females
T4774 6775-6778 CC denotes and
T4775 6779-6781 CD denotes 36
T4776 6781-6782 NN denotes %
T4777 6783-6786 IN denotes for
T4778 6787-6792 NNS denotes males
T4779 6792-6794 , denotes ,
T4780 6794-6799 WDT denotes which
T4781 6800-6802 VBZ denotes is
T4782 6803-6805 IN denotes in
T4783 6806-6811 JJ denotes close
T4784 6812-6821 NN denotes agreement
T4785 6822-6826 IN denotes with
T4786 6827-6835 JJ denotes previous
T4787 6836-6843 NNS denotes reports
T4788 6844-6845 -LRB- denotes [
T4789 6848-6850 CD denotes 19
T4790 6845-6847 CD denotes 18
T4791 6847-6848 , denotes ,
T4792 6850-6851 -RRB- denotes ]
T4793 6852-6855 CC denotes and
T4794 6856-6868 VBZ denotes demonstrates
T4795 6869-6880 JJ denotes significant
T4796 6881-6893 NN denotes heritability
T4797 6894-6896 IN denotes of
T4798 6897-6904 JJ denotes gonadal
T4799 6909-6913 NN denotes mass
T4800 6905-6908 NN denotes fat
T4801 6913-6914 . denotes .
T4802 6914-7109 sentence denotes Table 1 Characteristics of the BXH.ApoE−/− Cross A total of 334 F2 mice were genotyped at an average 1.5 cM density using 1,032 single nucleotide polymorphisms (SNPs) spanning all 19 autosomes.
T4803 6965-6966 DT denotes A
T4804 6967-6972 NN denotes total
T4805 6993-7002 VBN denotes genotyped
T4806 6973-6975 IN denotes of
T4807 6976-6979 CD denotes 334
T4808 6983-6987 NNS denotes mice
T4809 6980-6982 NN denotes F2
T4810 6988-6992 VBD denotes were
T4811 7003-7005 IN denotes at
T4812 7006-7008 DT denotes an
T4813 7024-7031 NN denotes density
T4814 7009-7016 JJ denotes average
T4815 7017-7020 CD denotes 1.5
T4816 7021-7023 NN denotes cM
T4817 7032-7037 VBG denotes using
T4818 7038-7043 CD denotes 1,032
T4819 7062-7075 NNS denotes polymorphisms
T4820 7044-7050 JJ denotes single
T4821 7051-7061 NN denotes nucleotide
T4822 7076-7077 -LRB- denotes (
T4823 7077-7081 NNS denotes SNPs
T4824 7081-7082 -RRB- denotes )
T4825 7083-7091 VBG denotes spanning
T4826 7092-7095 DT denotes all
T4827 7099-7108 NNS denotes autosomes
T4828 7096-7098 CD denotes 19
T4829 7108-7109 . denotes .
T4830 7109-7370 sentence denotes QTL analysis for several clinical traits (clinical QTLs [cQTLs]), including the unadjusted raw values for gonadal fat mass, was performed using a single marker regression approach (justified by the high-density of markers, making interval mapping unnecessary).
T4831 7110-7113 NN denotes QTL
T4832 7114-7122 NN denotes analysis
T4833 7238-7247 VBN denotes performed
T4834 7123-7126 IN denotes for
T4835 7127-7134 JJ denotes several
T4836 7144-7150 NNS denotes traits
T4837 7135-7143 JJ denotes clinical
T4838 7151-7152 -LRB- denotes (
T4839 7161-7165 NNS denotes QTLs
T4840 7152-7160 JJ denotes clinical
T4841 7166-7167 -LRB- denotes [
T4842 7167-7172 NNS denotes cQTLs
T4843 7172-7173 -RRB- denotes ]
T4844 7173-7174 -RRB- denotes )
T4845 7174-7176 , denotes ,
T4846 7176-7185 VBG denotes including
T4847 7186-7189 DT denotes the
T4848 7205-7211 NNS denotes values
T4849 7190-7200 JJ denotes unadjusted
T4850 7201-7204 JJ denotes raw
T4851 7212-7215 IN denotes for
T4852 7216-7223 JJ denotes gonadal
T4853 7228-7232 NN denotes mass
T4854 7224-7227 NN denotes fat
T4855 7232-7234 , denotes ,
T4856 7234-7237 VBD denotes was
T4857 7248-7253 VBG denotes using
T4858 7254-7255 DT denotes a
T4859 7281-7289 NN denotes approach
T4860 7256-7262 JJ denotes single
T4861 7263-7269 NN denotes marker
T4862 7270-7280 NN denotes regression
T4863 7290-7291 -LRB- denotes (
T4864 7291-7300 VBN denotes justified
T4865 7301-7303 IN denotes by
T4866 7304-7307 DT denotes the
T4867 7313-7320 NN denotes density
T4868 7308-7312 NN denotes high
T4869 7312-7313 HYPH denotes -
T4870 7321-7323 IN denotes of
T4871 7324-7331 NNS denotes markers
T4872 7331-7333 , denotes ,
T4873 7333-7339 VBG denotes making
T4874 7340-7348 NN denotes interval
T4875 7349-7356 NN denotes mapping
T4876 7357-7368 JJ denotes unnecessary
T4877 7368-7369 -RRB- denotes )
T4878 7369-7370 . denotes .
T4879 7370-7556 sentence denotes In order to test specifically for sex effects of linkage, we included additive, dominant, sex, sex-additive, and sex-dominant parameters in our calculations (see Materials and Methods).
T4880 7371-7373 IN denotes In
T4881 7432-7440 VBD denotes included
T4882 7374-7379 NN denotes order
T4883 7380-7382 TO denotes to
T4884 7383-7387 VB denotes test
T4885 7388-7400 RB denotes specifically
T4886 7401-7404 IN denotes for
T4887 7405-7408 NN denotes sex
T4888 7409-7416 NNS denotes effects
T4889 7417-7419 IN denotes of
T4890 7420-7427 NN denotes linkage
T4891 7427-7429 , denotes ,
T4892 7429-7431 PRP denotes we
T4893 7441-7449 JJ denotes additive
T4894 7497-7507 NNS denotes parameters
T4895 7449-7451 , denotes ,
T4896 7451-7459 JJ denotes dominant
T4897 7459-7461 , denotes ,
T4898 7461-7464 NN denotes sex
T4899 7464-7466 , denotes ,
T4900 7466-7469 NN denotes sex
T4901 7470-7478 JJ denotes additive
T4902 7469-7470 HYPH denotes -
T4903 7478-7480 , denotes ,
T4904 7480-7483 CC denotes and
T4905 7484-7487 NN denotes sex
T4906 7488-7496 JJ denotes dominant
T4907 7487-7488 HYPH denotes -
T4908 7508-7510 IN denotes in
T4909 7511-7514 PRP$ denotes our
T4910 7515-7527 NNS denotes calculations
T4911 7528-7529 -LRB- denotes (
T4912 7529-7532 VB denotes see
T4913 7533-7542 NNS denotes Materials
T4914 7543-7546 CC denotes and
T4915 7547-7554 NNS denotes Methods
T4916 7554-7555 -RRB- denotes )
T4917 7555-7556 . denotes .
T4918 7556-7766 sentence denotes A stepwise regression procedure was used to determine whether the addition of the final two terms significantly improved the linear regression model, conditional on realizing a significant additive QTL effect.
T4919 7557-7558 DT denotes A
T4920 7579-7588 NN denotes procedure
T4921 7559-7567 JJ denotes stepwise
T4922 7568-7578 NN denotes regression
T4923 7593-7597 VBN denotes used
T4924 7589-7592 VBD denotes was
T4925 7598-7600 TO denotes to
T4926 7601-7610 VB denotes determine
T4927 7611-7618 IN denotes whether
T4928 7669-7677 VBN denotes improved
T4929 7619-7622 DT denotes the
T4930 7623-7631 NN denotes addition
T4931 7632-7634 IN denotes of
T4932 7635-7638 DT denotes the
T4933 7649-7654 NNS denotes terms
T4934 7639-7644 JJ denotes final
T4935 7645-7648 CD denotes two
T4936 7655-7668 RB denotes significantly
T4937 7678-7681 DT denotes the
T4938 7700-7705 NN denotes model
T4939 7682-7688 JJ denotes linear
T4940 7689-7699 NN denotes regression
T4941 7705-7707 , denotes ,
T4942 7707-7718 JJ denotes conditional
T4943 7719-7721 IN denotes on
T4944 7722-7731 VBG denotes realizing
T4945 7732-7733 DT denotes a
T4946 7759-7765 NN denotes effect
T4947 7734-7745 JJ denotes significant
T4948 7746-7754 JJ denotes additive
T4949 7755-7758 NN denotes QTL
T4950 7765-7766 . denotes .
T4951 7766-7976 sentence denotes We performed permutation analyses over all gene expression traits, estimating false discovery rates (FDRs) at different logarithm of odds (LOD) score thresholds and assessing the overall rate of QTL detection.
T4952 7767-7769 PRP denotes We
T4953 7770-7779 VBD denotes performed
T4954 7780-7791 NN denotes permutation
T4955 7792-7800 NNS denotes analyses
T4956 7801-7805 IN denotes over
T4957 7806-7809 DT denotes all
T4958 7826-7832 NNS denotes traits
T4959 7810-7814 NN denotes gene
T4960 7815-7825 NN denotes expression
T4961 7832-7834 , denotes ,
T4962 7834-7844 VBG denotes estimating
T4963 7845-7850 JJ denotes false
T4964 7861-7866 NNS denotes rates
T4965 7851-7860 NN denotes discovery
T4966 7867-7868 -LRB- denotes (
T4967 7868-7872 NNS denotes FDRs
T4968 7872-7873 -RRB- denotes )
T4969 7874-7876 IN denotes at
T4970 7877-7886 JJ denotes different
T4971 7917-7927 NNS denotes thresholds
T4972 7887-7896 NN denotes logarithm
T4973 7897-7899 IN denotes of
T4974 7900-7904 NNS denotes odds
T4975 7905-7906 -LRB- denotes (
T4976 7906-7909 NN denotes LOD
T4977 7909-7910 -RRB- denotes )
T4978 7911-7916 NN denotes score
T4979 7928-7931 CC denotes and
T4980 7932-7941 VBG denotes assessing
T4981 7942-7945 DT denotes the
T4982 7954-7958 NN denotes rate
T4983 7946-7953 JJ denotes overall
T4984 7959-7961 IN denotes of
T4985 7962-7965 NN denotes QTL
T4986 7966-7975 NN denotes detection
T4987 7975-7976 . denotes .
T4988 7976-8262 sentence denotes From these analyses we constructed receiver operating characteristic (ROC)-like curves to demonstrate that our straightforward method has significantly increased power to detect QTLs compared to QTL mapping methods that do not incorporate sex and genotype–sex interactions (Figure S1).
T4989 7977-7981 IN denotes From
T4990 8000-8011 VBD denotes constructed
T4991 7982-7987 DT denotes these
T4992 7988-7996 NNS denotes analyses
T4993 7997-7999 PRP denotes we
T4994 8012-8020 NN denotes receiver
T4995 8021-8030 NN denotes operating
T4996 8052-8056 JJ denotes like
T4997 8031-8045 JJ denotes characteristic
T4998 8046-8047 -LRB- denotes (
T4999 8047-8050 NN denotes ROC
T5000 8050-8051 -RRB- denotes )
T5001 8051-8052 HYPH denotes -
T5002 8057-8063 NNS denotes curves
T5003 8064-8066 TO denotes to
T5004 8067-8078 VB denotes demonstrate
T5005 8079-8083 IN denotes that
T5006 8111-8114 VBZ denotes has
T5007 8084-8087 PRP$ denotes our
T5008 8104-8110 NN denotes method
T5009 8088-8103 JJ denotes straightforward
T5010 8115-8128 RB denotes significantly
T5011 8129-8138 JJ denotes increased
T5012 8139-8144 NN denotes power
T5013 8145-8147 TO denotes to
T5014 8148-8154 VB denotes detect
T5015 8155-8159 NNS denotes QTLs
T5016 8160-8168 VBN denotes compared
T5017 8169-8171 IN denotes to
T5018 8172-8175 NN denotes QTL
T5019 8184-8191 NNS denotes methods
T5020 8176-8183 NN denotes mapping
T5021 8192-8196 WDT denotes that
T5022 8204-8215 VB denotes incorporate
T5023 8197-8199 VBP denotes do
T5024 8200-8203 RB denotes not
T5025 8216-8219 NN denotes sex
T5026 8220-8223 CC denotes and
T5027 8224-8232 NN denotes genotype
T5028 8233-8236 NN denotes sex
T5029 8232-8233 HYPH denotes –
T5030 8237-8249 NNS denotes interactions
T5031 8250-8251 -LRB- denotes (
T5032 8258-8260 NN denotes S1
T5033 8251-8257 NN denotes Figure
T5034 8260-8261 -RRB- denotes )
T5035 8261-8262 . denotes .
T5036 8262-8407 sentence denotes It is clear from the ROC curves that the sex and sex-interaction terms add significantly to the detection of QTL for the gene expression traits.
T5037 8263-8265 PRP denotes It
T5038 8266-8268 VBZ denotes is
T5039 8269-8274 JJ denotes clear
T5040 8275-8279 IN denotes from
T5041 8280-8283 DT denotes the
T5042 8288-8294 NNS denotes curves
T5043 8284-8287 NN denotes ROC
T5044 8295-8299 IN denotes that
T5045 8334-8337 VBP denotes add
T5046 8300-8303 DT denotes the
T5047 8328-8333 NNS denotes terms
T5048 8304-8307 NN denotes sex
T5049 8308-8311 CC denotes and
T5050 8312-8315 NN denotes sex
T5051 8316-8327 NN denotes interaction
T5052 8315-8316 HYPH denotes -
T5053 8338-8351 RB denotes significantly
T5054 8352-8354 IN denotes to
T5055 8355-8358 DT denotes the
T5056 8359-8368 NN denotes detection
T5057 8369-8371 IN denotes of
T5058 8372-8375 NN denotes QTL
T5059 8376-8379 IN denotes for
T5060 8380-8383 DT denotes the
T5061 8400-8406 NNS denotes traits
T5062 8384-8388 NN denotes gene
T5063 8389-8399 NN denotes expression
T5064 8406-8407 . denotes .
T5065 8407-8648 sentence denotes Using previously described conventions [20], QTL models without the final two interaction terms (sex*add and sex*dom) have a suggestive threshold of 3.0 (p < 1 × 10−3) and a significant threshold of 4.3 (p < 5 × 10−5, genome-wide p < 0.05).
T5066 8408-8413 VBG denotes Using
T5067 8526-8530 VBP denotes have
T5068 8414-8424 RB denotes previously
T5069 8425-8434 VBN denotes described
T5070 8435-8446 NNS denotes conventions
T5071 8447-8448 -LRB- denotes [
T5072 8448-8450 CD denotes 20
T5073 8450-8451 -RRB- denotes ]
T5074 8451-8453 , denotes ,
T5075 8453-8456 NN denotes QTL
T5076 8457-8463 NNS denotes models
T5077 8464-8471 IN denotes without
T5078 8472-8475 DT denotes the
T5079 8498-8503 NNS denotes terms
T5080 8476-8481 JJ denotes final
T5081 8482-8485 CD denotes two
T5082 8486-8497 NN denotes interaction
T5083 8504-8505 -LRB- denotes (
T5084 8505-8508 NN denotes sex
T5085 8509-8512 NN denotes add
T5086 8508-8509 SYM denotes *
T5087 8513-8516 CC denotes and
T5088 8517-8520 NN denotes sex
T5089 8521-8524 NN denotes dom
T5090 8520-8521 SYM denotes *
T5091 8524-8525 -RRB- denotes )
T5092 8531-8532 DT denotes a
T5093 8544-8553 NN denotes threshold
T5094 8533-8543 JJ denotes suggestive
T5095 8554-8556 IN denotes of
T5096 8557-8560 CD denotes 3.0
T5097 8561-8562 -LRB- denotes (
T5098 8566-8567 CD denotes 1
T5099 8562-8563 NN denotes p
T5100 8564-8565 SYM denotes <
T5101 8568-8569 SYM denotes ×
T5102 8570-8572 CD denotes 10
T5103 8573-8574 CD denotes 3
T5104 8572-8573 SYM denotes −
T5105 8574-8575 -RRB- denotes )
T5106 8576-8579 CC denotes and
T5107 8580-8581 DT denotes a
T5108 8594-8603 NN denotes threshold
T5109 8582-8593 JJ denotes significant
T5110 8604-8606 IN denotes of
T5111 8607-8610 CD denotes 4.3
T5112 8611-8612 -LRB- denotes (
T5113 8642-8646 CD denotes 0.05
T5114 8612-8613 NN denotes p
T5115 8616-8617 CD denotes 5
T5116 8614-8615 SYM denotes <
T5117 8618-8619 SYM denotes ×
T5118 8620-8622 CD denotes 10
T5119 8623-8624 CD denotes 5
T5120 8622-8623 SYM denotes −
T5121 8624-8626 , denotes ,
T5122 8626-8632 NN denotes genome
T5123 8633-8637 JJ denotes wide
T5124 8632-8633 HYPH denotes -
T5125 8638-8639 NN denotes p
T5126 8640-8641 SYM denotes <
T5127 8646-8647 -RRB- denotes )
T5128 8647-8648 . denotes .
T5129 8648-8943 sentence denotes QTL models incorporating only the sex*add interaction term in addition to the additive terms have one extra degree of freedom that leads to a corresponding increase in the LOD score thresholds to 3.5 (suggestive) and 4.9 (significant) for the 0.001 and 0.00005 p-value thresholds, respectively.
T5130 8649-8652 NN denotes QTL
T5131 8653-8659 NNS denotes models
T5132 8742-8746 VBP denotes have
T5133 8660-8673 VBG denotes incorporating
T5134 8674-8678 RB denotes only
T5135 8679-8682 DT denotes the
T5136 8703-8707 NN denotes term
T5137 8683-8686 NN denotes sex
T5138 8687-8690 NN denotes add
T5139 8686-8687 SYM denotes *
T5140 8691-8702 NN denotes interaction
T5141 8708-8710 IN denotes in
T5142 8711-8719 NN denotes addition
T5143 8720-8722 IN denotes to
T5144 8723-8726 DT denotes the
T5145 8736-8741 NNS denotes terms
T5146 8727-8735 JJ denotes additive
T5147 8747-8750 CD denotes one
T5148 8757-8763 NN denotes degree
T5149 8751-8756 JJ denotes extra
T5150 8764-8766 IN denotes of
T5151 8767-8774 NN denotes freedom
T5152 8775-8779 WDT denotes that
T5153 8780-8785 VBZ denotes leads
T5154 8786-8788 IN denotes to
T5155 8789-8790 DT denotes a
T5156 8805-8813 NN denotes increase
T5157 8791-8804 VBG denotes corresponding
T5158 8814-8816 IN denotes in
T5159 8817-8820 DT denotes the
T5160 8831-8841 NNS denotes thresholds
T5161 8821-8824 NN denotes LOD
T5162 8825-8830 NN denotes score
T5163 8842-8844 IN denotes to
T5164 8845-8848 CD denotes 3.5
T5165 8849-8850 -LRB- denotes (
T5166 8850-8860 JJ denotes suggestive
T5167 8860-8861 -RRB- denotes )
T5168 8862-8865 CC denotes and
T5169 8866-8869 CD denotes 4.9
T5170 8870-8871 -LRB- denotes (
T5171 8871-8882 JJ denotes significant
T5172 8882-8883 -RRB- denotes )
T5173 8884-8887 IN denotes for
T5174 8888-8891 DT denotes the
T5175 8918-8928 NNS denotes thresholds
T5176 8892-8897 CD denotes 0.001
T5177 8898-8901 CC denotes and
T5178 8902-8909 CD denotes 0.00005
T5179 8910-8911 NN denotes p
T5180 8912-8917 NN denotes value
T5181 8911-8912 HYPH denotes -
T5182 8928-8930 , denotes ,
T5183 8930-8942 RB denotes respectively
T5184 8942-8943 . denotes .
T5185 8943-9205 sentence denotes QTL models incorporating both sex*add and sex*dom interaction terms possess two extra degrees of freedom, with a corresponding increase in LOD score thresholds to 4.0 (suggestive) and 5.4 (significant) for the 0.001 and 0.00005 p-value thresholds, respectively.
T5186 8944-8947 NN denotes QTL
T5187 8948-8954 NNS denotes models
T5188 9012-9019 VBP denotes possess
T5189 8955-8968 VBG denotes incorporating
T5190 8969-8973 CC denotes both
T5191 8978-8981 NN denotes add
T5192 8974-8977 NN denotes sex
T5193 8977-8978 SYM denotes *
T5194 9006-9011 NNS denotes terms
T5195 8982-8985 CC denotes and
T5196 8986-8989 NN denotes sex
T5197 8990-8993 NN denotes dom
T5198 8989-8990 SYM denotes *
T5199 8994-9005 NN denotes interaction
T5200 9020-9023 CD denotes two
T5201 9030-9037 NNS denotes degrees
T5202 9024-9029 JJ denotes extra
T5203 9038-9040 IN denotes of
T5204 9041-9048 NN denotes freedom
T5205 9048-9050 , denotes ,
T5206 9050-9054 IN denotes with
T5207 9055-9056 DT denotes a
T5208 9071-9079 NN denotes increase
T5209 9057-9070 VBG denotes corresponding
T5210 9080-9082 IN denotes in
T5211 9083-9086 NN denotes LOD
T5212 9093-9103 NNS denotes thresholds
T5213 9087-9092 NN denotes score
T5214 9104-9106 IN denotes to
T5215 9107-9110 CD denotes 4.0
T5216 9111-9112 -LRB- denotes (
T5217 9112-9122 JJ denotes suggestive
T5218 9122-9123 -RRB- denotes )
T5219 9124-9127 CC denotes and
T5220 9128-9131 CD denotes 5.4
T5221 9132-9133 -LRB- denotes (
T5222 9133-9144 JJ denotes significant
T5223 9144-9145 -RRB- denotes )
T5224 9146-9149 IN denotes for
T5225 9150-9153 DT denotes the
T5226 9180-9190 NNS denotes thresholds
T5227 9154-9159 CD denotes 0.001
T5228 9160-9163 CC denotes and
T5229 9164-9171 CD denotes 0.00005
T5230 9172-9173 NN denotes p
T5231 9174-9179 NN denotes value
T5232 9173-9174 HYPH denotes -
T5233 9190-9192 , denotes ,
T5234 9192-9204 RB denotes respectively
T5235 9204-9205 . denotes .
T5236 9205-9362 sentence denotes One suggestive (Chromosome 1) and four significant (Chromosomes 3, 5, 11, and 19) cQTLs for the gonadal fat mass trait were identified (Figure 1A; Table 2).
T5237 9206-9209 CD denotes One
T5238 9210-9220 JJ denotes suggestive
T5239 9288-9293 NNS denotes cQTLs
T5240 9221-9222 -LRB- denotes (
T5241 9222-9232 NN denotes Chromosome
T5242 9233-9234 CD denotes 1
T5243 9234-9235 -RRB- denotes )
T5244 9236-9239 CC denotes and
T5245 9240-9244 CD denotes four
T5246 9245-9256 JJ denotes significant
T5247 9257-9258 -LRB- denotes (
T5248 9270-9271 CD denotes 3
T5249 9258-9269 NNS denotes Chromosomes
T5250 9271-9273 , denotes ,
T5251 9273-9274 CD denotes 5
T5252 9274-9276 , denotes ,
T5253 9276-9278 CD denotes 11
T5254 9278-9280 , denotes ,
T5255 9280-9283 CC denotes and
T5256 9284-9286 CD denotes 19
T5257 9286-9287 -RRB- denotes )
T5258 9330-9340 VBN denotes identified
T5259 9294-9297 IN denotes for
T5260 9298-9301 DT denotes the
T5261 9319-9324 NN denotes trait
T5262 9302-9309 JJ denotes gonadal
T5263 9314-9318 NN denotes mass
T5264 9310-9313 NN denotes fat
T5265 9325-9329 VBD denotes were
T5266 9341-9342 -LRB- denotes (
T5267 9353-9358 NN denotes Table
T5268 9342-9348 NN denotes Figure
T5269 9349-9351 NN denotes 1A
T5270 9351-9352 : denotes ;
T5271 9359-9360 CD denotes 2
T5272 9360-9361 -RRB- denotes )
T5273 9361-9362 . denotes .
T5274 9362-9568 sentence denotes Four out of the five cQTLs showed statistically significant better fits with the full model incorporating the interaction terms sex*add and sex*dom, compared to the model including only the additive terms.
T5275 9363-9367 CD denotes Four
T5276 9379-9383 CD denotes five
T5277 9368-9371 IN denotes out
T5278 9372-9374 IN denotes of
T5279 9375-9378 DT denotes the
T5280 9384-9389 NNS denotes cQTLs
T5281 9390-9396 VBD denotes showed
T5282 9397-9410 RB denotes statistically
T5283 9411-9422 JJ denotes significant
T5284 9430-9434 NNS denotes fits
T5285 9423-9429 JJR denotes better
T5286 9435-9439 IN denotes with
T5287 9440-9443 DT denotes the
T5288 9449-9454 NN denotes model
T5289 9444-9448 JJ denotes full
T5290 9455-9468 VBG denotes incorporating
T5291 9469-9472 DT denotes the
T5292 9485-9490 NNS denotes terms
T5293 9473-9484 NN denotes interaction
T5294 9491-9494 NN denotes sex
T5295 9494-9495 SYM denotes *
T5296 9495-9498 NN denotes add
T5297 9499-9502 CC denotes and
T5298 9503-9506 NN denotes sex
T5299 9506-9507 SYM denotes *
T5300 9507-9510 NN denotes dom
T5301 9510-9512 , denotes ,
T5302 9512-9520 VBN denotes compared
T5303 9521-9523 IN denotes to
T5304 9524-9527 DT denotes the
T5305 9528-9533 NN denotes model
T5306 9534-9543 VBG denotes including
T5307 9544-9548 RB denotes only
T5308 9562-9567 NNS denotes terms
T5309 9549-9552 DT denotes the
T5310 9553-9561 JJ denotes additive
T5311 9567-9568 . denotes .
T5312 9568-9721 sentence denotes Interestingly, the cQTL over Chromosome 11 did not improve, suggesting that the additional terms did not contribute to improved detection of this locus.
T5313 9569-9582 RB denotes Interestingly
T5314 9620-9627 VB denotes improve
T5315 9582-9584 , denotes ,
T5316 9584-9587 DT denotes the
T5317 9588-9592 NN denotes cQTL
T5318 9593-9597 IN denotes over
T5319 9598-9608 NN denotes Chromosome
T5320 9609-9611 CD denotes 11
T5321 9612-9615 VBD denotes did
T5322 9616-9619 RB denotes not
T5323 9627-9629 , denotes ,
T5324 9629-9639 VBG denotes suggesting
T5325 9640-9644 IN denotes that
T5326 9674-9684 VB denotes contribute
T5327 9645-9648 DT denotes the
T5328 9660-9665 NNS denotes terms
T5329 9649-9659 JJ denotes additional
T5330 9666-9669 VBD denotes did
T5331 9670-9673 RB denotes not
T5332 9685-9687 IN denotes to
T5333 9688-9696 VBN denotes improved
T5334 9697-9706 NN denotes detection
T5335 9707-9709 IN denotes of
T5336 9710-9714 DT denotes this
T5337 9715-9720 NN denotes locus
T5338 9720-9721 . denotes .
T5339 9721-9801 sentence denotes Table 2 summarizes the position and LOD score of maximal linkage for each cQTL.
T5340 9722-9727 NN denotes Table
T5341 9730-9740 VBZ denotes summarizes
T5342 9728-9729 CD denotes 2
T5343 9741-9744 DT denotes the
T5344 9745-9753 NN denotes position
T5345 9754-9757 CC denotes and
T5346 9758-9761 NN denotes LOD
T5347 9762-9767 NN denotes score
T5348 9768-9770 IN denotes of
T5349 9771-9778 JJ denotes maximal
T5350 9779-9786 NN denotes linkage
T5351 9787-9790 IN denotes for
T5352 9791-9795 DT denotes each
T5353 9796-9800 NN denotes cQTL
T5354 9800-9801 . denotes .
T5355 9801-10027 sentence denotes While the focus of this study was the gonadal fat mass trait, it is noted that a genome scan for the adiposity trait resulted in cQTLs at the same locations, with very similar LOD scores and sex dependence (unpublished data).
T5356 9802-9807 IN denotes While
T5357 9832-9835 VBD denotes was
T5358 9808-9811 DT denotes the
T5359 9812-9817 NN denotes focus
T5360 9818-9820 IN denotes of
T5361 9821-9825 DT denotes this
T5362 9826-9831 NN denotes study
T5363 9870-9875 VBN denotes noted
T5364 9836-9839 DT denotes the
T5365 9857-9862 NN denotes trait
T5366 9840-9847 JJ denotes gonadal
T5367 9852-9856 NN denotes mass
T5368 9848-9851 NN denotes fat
T5369 9862-9864 , denotes ,
T5370 9864-9866 PRP denotes it
T5371 9867-9869 VBZ denotes is
T5372 9876-9880 IN denotes that
T5373 9919-9927 VBD denotes resulted
T5374 9881-9882 DT denotes a
T5375 9890-9894 NN denotes scan
T5376 9883-9889 NN denotes genome
T5377 9895-9898 IN denotes for
T5378 9899-9902 DT denotes the
T5379 9913-9918 NN denotes trait
T5380 9903-9912 NN denotes adiposity
T5381 9928-9930 IN denotes in
T5382 9931-9936 NNS denotes cQTLs
T5383 9937-9939 IN denotes at
T5384 9940-9943 DT denotes the
T5385 9949-9958 NNS denotes locations
T5386 9944-9948 JJ denotes same
T5387 9958-9960 , denotes ,
T5388 9960-9964 IN denotes with
T5389 9965-9969 RB denotes very
T5390 9970-9977 JJ denotes similar
T5391 9982-9988 NNS denotes scores
T5392 9978-9981 NN denotes LOD
T5393 9989-9992 CC denotes and
T5394 9993-9996 NN denotes sex
T5395 9997-10007 NN denotes dependence
T5396 10008-10009 -LRB- denotes (
T5397 10021-10025 NNS denotes data
T5398 10009-10020 JJ denotes unpublished
T5399 10025-10026 -RRB- denotes )
T5400 10026-10027 . denotes .
T5401 10027-11344 sentence denotes Figure 1 Genome Scan for Gonadal Fat Mass (A) Animals were genotyped at an average 1.5 cM density using 1,032 SNPs polymorphic between the parental strains. LOD scores computed using sex as an additive covariate (black) failed to detect significant linkage. A genome scan accounting for interactions between sex and QTL (red) showed evidence for suggestive linkage on Chromosome 1 and significant linkage on Chromosomes 3, 5, 11, and 19. Dashed and solid lines are thresholds for suggestive (p < 1 × 10−3) and significant linkage (p < 5 × 10−5), respectively. (B) Genome scans for gonadal fat mass using different models over mouse Chromosome 5. Scans for fat mass using all animals with (black) and without (green) sex as an additive covariate failed to detect significant linkage. Females analyzed alone (magenta) showed evidence for suggestive linkage (p < 2 × 10−4). When both sexes were analyzed to account for sex effects (red), a significant QTL was realized (p < 10−6). For clarity, only the model incorporating both the “sex*add” and “sex*dom” terms is shown in red, although additional models incorporating the terms separately were also computed. Table 2 cQTLs for Gonadal Fat Mass Results from the various regression models used to determine linkage for the Chromosome 5 cQTL are depicted in Figure 1B.
T5402 11223-11230 NNS denotes Results
T5403 11322-11330 VBN denotes depicted
T5404 11231-11235 IN denotes from
T5405 11236-11239 DT denotes the
T5406 11259-11265 NNS denotes models
T5407 11240-11247 JJ denotes various
T5408 11248-11258 NN denotes regression
T5409 11266-11270 VBN denotes used
T5410 11271-11273 TO denotes to
T5411 11274-11283 VB denotes determine
T5412 11284-11291 NN denotes linkage
T5413 11292-11295 IN denotes for
T5414 11296-11299 DT denotes the
T5415 11313-11317 NN denotes cQTL
T5416 11300-11310 NN denotes Chromosome
T5417 11311-11312 CD denotes 5
T5418 11318-11321 VBP denotes are
T5419 11331-11333 IN denotes in
T5420 11334-11340 NN denotes Figure
T5421 11341-11343 NN denotes 1B
T5422 11343-11344 . denotes .
T5423 11344-11463 sentence denotes Analysis of all animals with and without sex as a covariate failed to demonstrate evidence of linkage on Chromosome 5.
T5424 11345-11353 NN denotes Analysis
T5425 11405-11411 VBD denotes failed
T5426 11354-11356 IN denotes of
T5427 11357-11360 DT denotes all
T5428 11361-11368 NNS denotes animals
T5429 11369-11373 IN denotes with
T5430 11374-11377 CC denotes and
T5431 11378-11385 IN denotes without
T5432 11386-11389 NN denotes sex
T5433 11390-11392 IN denotes as
T5434 11393-11394 DT denotes a
T5435 11395-11404 NN denotes covariate
T5436 11412-11414 TO denotes to
T5437 11415-11426 VB denotes demonstrate
T5438 11427-11435 NN denotes evidence
T5439 11436-11438 IN denotes of
T5440 11439-11446 NN denotes linkage
T5441 11447-11449 IN denotes on
T5442 11450-11460 NN denotes Chromosome
T5443 11461-11462 CD denotes 5
T5444 11462-11463 . denotes .
T5445 11463-11619 sentence denotes When females were analyzed alone, a suggestive LOD score of 3.7 was realized (p = 2 × 10−4); males analyzed alone did not demonstrate evidence for linkage.
T5446 11464-11468 WRB denotes When
T5447 11482-11490 VBN denotes analyzed
T5448 11469-11476 NNS denotes females
T5449 11477-11481 VBD denotes were
T5450 11532-11540 VBN denotes realized
T5451 11491-11496 RB denotes alone
T5452 11496-11498 , denotes ,
T5453 11498-11499 DT denotes a
T5454 11515-11520 NN denotes score
T5455 11500-11510 JJ denotes suggestive
T5456 11511-11514 NN denotes LOD
T5457 11521-11523 IN denotes of
T5458 11524-11527 CD denotes 3.7
T5459 11528-11531 VBD denotes was
T5460 11586-11597 VB denotes demonstrate
T5461 11541-11542 -LRB- denotes (
T5462 11546-11547 CD denotes 2
T5463 11542-11543 NN denotes p
T5464 11544-11545 SYM denotes =
T5465 11548-11549 SYM denotes ×
T5466 11550-11552 CD denotes 10
T5467 11553-11554 CD denotes 4
T5468 11552-11553 SYM denotes −
T5469 11554-11555 -RRB- denotes )
T5470 11555-11556 : denotes ;
T5471 11557-11562 NNS denotes males
T5472 11563-11571 VBN denotes analyzed
T5473 11572-11577 RB denotes alone
T5474 11578-11581 VBD denotes did
T5475 11582-11585 RB denotes not
T5476 11598-11606 NN denotes evidence
T5477 11607-11610 IN denotes for
T5478 11611-11618 NN denotes linkage
T5479 11618-11619 . denotes .
T5480 11619-11805 sentence denotes However, using all 334 animals and adding the interaction terms to the QTL model significantly improved sensitivity, and a cQTL with a maximum LOD of 7.56 (p = 1.7 × 10−6) was realized.
T5481 11620-11627 RB denotes However
T5482 11715-11723 VBD denotes improved
T5483 11627-11629 , denotes ,
T5484 11629-11634 VBG denotes using
T5485 11635-11638 DT denotes all
T5486 11643-11650 NNS denotes animals
T5487 11639-11642 CD denotes 334
T5488 11651-11654 CC denotes and
T5489 11655-11661 VBG denotes adding
T5490 11662-11665 DT denotes the
T5491 11678-11683 NNS denotes terms
T5492 11666-11677 NN denotes interaction
T5493 11684-11686 IN denotes to
T5494 11687-11690 DT denotes the
T5495 11695-11700 NN denotes model
T5496 11691-11694 NN denotes QTL
T5497 11701-11714 RB denotes significantly
T5498 11724-11735 NN denotes sensitivity
T5499 11735-11737 , denotes ,
T5500 11737-11740 CC denotes and
T5501 11741-11742 DT denotes a
T5502 11743-11747 NN denotes cQTL
T5503 11796-11804 VBN denotes realized
T5504 11748-11752 IN denotes with
T5505 11753-11754 DT denotes a
T5506 11763-11766 NN denotes LOD
T5507 11755-11762 NN denotes maximum
T5508 11767-11769 IN denotes of
T5509 11770-11774 CD denotes 7.56
T5510 11775-11776 -LRB- denotes (
T5511 11780-11783 CD denotes 1.7
T5512 11776-11777 NN denotes p
T5513 11778-11779 SYM denotes =
T5514 11784-11785 SYM denotes ×
T5515 11786-11788 CD denotes 10
T5516 11789-11790 CD denotes 6
T5517 11788-11789 SYM denotes −
T5518 11790-11791 -RRB- denotes )
T5519 11792-11795 VBD denotes was
T5520 11804-11805 . denotes .
T5521 11805-12064 sentence denotes Given the improved detection of four of the five cQTLs when sex-additive and sex-dominant interaction terms were considered, we hypothesized that the main genotype effect of these cQTLs on the gonadal fat mass trait would differ between the sexes (Figure 2).
T5522 11806-11811 VBN denotes Given
T5523 11934-11946 VBD denotes hypothesized
T5524 11812-11815 DT denotes the
T5525 11825-11834 NN denotes detection
T5526 11816-11824 VBN denotes improved
T5527 11835-11837 IN denotes of
T5528 11838-11842 CD denotes four
T5529 11850-11854 CD denotes five
T5530 11843-11845 IN denotes of
T5531 11846-11849 DT denotes the
T5532 11855-11860 NNS denotes cQTLs
T5533 11861-11865 WRB denotes when
T5534 11919-11929 VBN denotes considered
T5535 11866-11869 NN denotes sex
T5536 11870-11878 JJ denotes additive
T5537 11869-11870 HYPH denotes -
T5538 11908-11913 NNS denotes terms
T5539 11879-11882 CC denotes and
T5540 11883-11886 NN denotes sex
T5541 11887-11895 JJ denotes dominant
T5542 11886-11887 HYPH denotes -
T5543 11896-11907 NN denotes interaction
T5544 11914-11918 VBD denotes were
T5545 11929-11931 , denotes ,
T5546 11931-11933 PRP denotes we
T5547 11947-11951 IN denotes that
T5548 12028-12034 VB denotes differ
T5549 11952-11955 DT denotes the
T5550 11970-11976 NN denotes effect
T5551 11956-11960 JJ denotes main
T5552 11961-11969 NN denotes genotype
T5553 11977-11979 IN denotes of
T5554 11980-11985 DT denotes these
T5555 11986-11991 NNS denotes cQTLs
T5556 11992-11994 IN denotes on
T5557 11995-11998 DT denotes the
T5558 12016-12021 NN denotes trait
T5559 11999-12006 JJ denotes gonadal
T5560 12011-12015 NN denotes mass
T5561 12007-12010 NN denotes fat
T5562 12022-12027 MD denotes would
T5563 12035-12042 IN denotes between
T5564 12043-12046 DT denotes the
T5565 12047-12052 NNS denotes sexes
T5566 12053-12054 -LRB- denotes (
T5567 12054-12060 NN denotes Figure
T5568 12061-12062 CD denotes 2
T5569 12062-12063 -RRB- denotes )
T5570 12063-12064 . denotes .
T5571 12064-12169 sentence denotes Indeed, cQTLs located on Chromosomes 1, 3, and 5 showed opposing effects on fat mass, or sex antagonism.
T5572 12065-12071 RB denotes Indeed
T5573 12114-12120 VBD denotes showed
T5574 12071-12073 , denotes ,
T5575 12073-12078 NNS denotes cQTLs
T5576 12079-12086 VBN denotes located
T5577 12087-12089 IN denotes on
T5578 12090-12101 NNS denotes Chromosomes
T5579 12102-12103 CD denotes 1
T5580 12103-12105 , denotes ,
T5581 12105-12106 CD denotes 3
T5582 12106-12108 , denotes ,
T5583 12108-12111 CC denotes and
T5584 12112-12113 CD denotes 5
T5585 12121-12129 VBG denotes opposing
T5586 12130-12137 NNS denotes effects
T5587 12138-12140 IN denotes on
T5588 12141-12144 NN denotes fat
T5589 12145-12149 NN denotes mass
T5590 12149-12151 , denotes ,
T5591 12151-12153 CC denotes or
T5592 12154-12157 NN denotes sex
T5593 12158-12168 NN denotes antagonism
T5594 12168-12169 . denotes .
T5595 12169-12422 sentence denotes The effect of the cQTL on Chromosome 11 was in the same direction in both males and females, but was sex-biased toward a larger effect in females (R 2 = 0.091 in females versus R 2 = 0.046 in males), confirming the minimal sex specificity of this cQTL.
T5596 12170-12173 DT denotes The
T5597 12174-12180 NN denotes effect
T5598 12210-12213 VBD denotes was
T5599 12181-12183 IN denotes of
T5600 12184-12187 DT denotes the
T5601 12188-12192 NN denotes cQTL
T5602 12193-12195 IN denotes on
T5603 12196-12206 NN denotes Chromosome
T5604 12207-12209 CD denotes 11
T5605 12214-12216 IN denotes in
T5606 12217-12220 DT denotes the
T5607 12226-12235 NN denotes direction
T5608 12221-12225 JJ denotes same
T5609 12236-12238 IN denotes in
T5610 12239-12243 CC denotes both
T5611 12244-12249 NNS denotes males
T5612 12250-12253 CC denotes and
T5613 12254-12261 NNS denotes females
T5614 12261-12263 , denotes ,
T5615 12263-12266 CC denotes but
T5616 12267-12270 VBD denotes was
T5617 12275-12281 VBN denotes biased
T5618 12271-12274 NN denotes sex
T5619 12274-12275 HYPH denotes -
T5620 12282-12288 IN denotes toward
T5621 12289-12290 DT denotes a
T5622 12298-12304 NN denotes effect
T5623 12291-12297 JJR denotes larger
T5624 12305-12307 IN denotes in
T5625 12308-12315 NNS denotes females
T5626 12316-12317 -LRB- denotes (
T5627 12323-12328 CD denotes 0.091
T5628 12317-12320 NN denotes R 2
T5629 12321-12322 SYM denotes =
T5630 12329-12331 IN denotes in
T5631 12332-12339 NNS denotes females
T5632 12340-12346 CC denotes versus
T5633 12347-12350 NN denotes R 2
T5634 12353-12358 CD denotes 0.046
T5635 12351-12352 SYM denotes =
T5636 12359-12361 IN denotes in
T5637 12362-12367 NNS denotes males
T5638 12367-12368 -RRB- denotes )
T5639 12368-12370 , denotes ,
T5640 12370-12380 VBG denotes confirming
T5641 12381-12384 DT denotes the
T5642 12397-12408 NN denotes specificity
T5643 12385-12392 JJ denotes minimal
T5644 12393-12396 NN denotes sex
T5645 12409-12411 IN denotes of
T5646 12412-12416 DT denotes this
T5647 12417-12421 NN denotes cQTL
T5648 12421-12422 . denotes .
T5649 12422-12514 sentence denotes The cQTL on Chromosome 19 showed a sex-specific effect in females, with no effect in males.
T5650 12423-12426 DT denotes The
T5651 12427-12431 NN denotes cQTL
T5652 12449-12455 VBD denotes showed
T5653 12432-12434 IN denotes on
T5654 12435-12445 NN denotes Chromosome
T5655 12446-12448 CD denotes 19
T5656 12456-12457 DT denotes a
T5657 12471-12477 NN denotes effect
T5658 12458-12461 NN denotes sex
T5659 12462-12470 JJ denotes specific
T5660 12461-12462 HYPH denotes -
T5661 12478-12480 IN denotes in
T5662 12481-12488 NNS denotes females
T5663 12488-12490 , denotes ,
T5664 12490-12494 IN denotes with
T5665 12495-12497 DT denotes no
T5666 12498-12504 NN denotes effect
T5667 12505-12507 IN denotes in
T5668 12508-12513 NNS denotes males
T5669 12513-12514 . denotes .
T5670 12514-12958 sentence denotes Figure 2 Effect of Genotype on Fat Mass Homozygous B6 (BB), C3H (CC), or heterozygous (BC) genotype at all five QTL positions, separated by sex, are shown. The underlying genotypic effects of the QTLs on fat mass differ between the sexes. Coefficients of determination (R 2) are shown along with associated ANOVAs *p < 0.05, **p < 0.01, ***p < 0.001. Overall, all five cQTLs for gonadal fat mass were biased toward a larger effect in females.
T5671 12867-12874 RB denotes Overall
T5672 12912-12916 VBD denotes were
T5673 12874-12876 , denotes ,
T5674 12876-12879 DT denotes all
T5675 12885-12890 NNS denotes cQTLs
T5676 12880-12884 CD denotes five
T5677 12891-12894 IN denotes for
T5678 12895-12902 JJ denotes gonadal
T5679 12907-12911 NN denotes mass
T5680 12903-12906 NN denotes fat
T5681 12917-12923 JJ denotes biased
T5682 12924-12930 IN denotes toward
T5683 12931-12932 DT denotes a
T5684 12940-12946 NN denotes effect
T5685 12933-12939 JJR denotes larger
T5686 12947-12949 IN denotes in
T5687 12950-12957 NNS denotes females
T5688 12957-12958 . denotes .
T5689 12958-13302 sentence denotes Assuming purely additive effects of each genotype, these cQTLs account for approximately 42% of the variation in female F2 mice and 13% in males, consistent with the narrow sense heritability estimates for this trait and again demonstrating significant differences in the regulation and heritability of the gonadal fat trait between the sexes.
T5690 12959-12967 VBG denotes Assuming
T5691 13022-13029 VBP denotes account
T5692 12968-12974 RB denotes purely
T5693 12975-12983 JJ denotes additive
T5694 12984-12991 NNS denotes effects
T5695 12992-12994 IN denotes of
T5696 12995-12999 DT denotes each
T5697 13000-13008 NN denotes genotype
T5698 13008-13010 , denotes ,
T5699 13010-13015 DT denotes these
T5700 13016-13021 NNS denotes cQTLs
T5701 13030-13033 IN denotes for
T5702 13034-13047 RB denotes approximately
T5703 13048-13050 CD denotes 42
T5704 13050-13051 NN denotes %
T5705 13052-13054 IN denotes of
T5706 13055-13058 DT denotes the
T5707 13059-13068 NN denotes variation
T5708 13069-13071 IN denotes in
T5709 13072-13078 JJ denotes female
T5710 13082-13086 NNS denotes mice
T5711 13079-13081 NN denotes F2
T5712 13087-13090 CC denotes and
T5713 13091-13093 CD denotes 13
T5714 13093-13094 NN denotes %
T5715 13095-13097 IN denotes in
T5716 13098-13103 NNS denotes males
T5717 13103-13105 , denotes ,
T5718 13105-13115 JJ denotes consistent
T5719 13116-13120 IN denotes with
T5720 13121-13124 DT denotes the
T5721 13151-13160 NNS denotes estimates
T5722 13125-13131 JJ denotes narrow
T5723 13132-13137 NN denotes sense
T5724 13138-13150 NN denotes heritability
T5725 13161-13164 IN denotes for
T5726 13165-13169 DT denotes this
T5727 13170-13175 NN denotes trait
T5728 13176-13179 CC denotes and
T5729 13180-13185 RB denotes again
T5730 13186-13199 VBG denotes demonstrating
T5731 13200-13211 JJ denotes significant
T5732 13212-13223 NNS denotes differences
T5733 13224-13226 IN denotes in
T5734 13227-13230 DT denotes the
T5735 13231-13241 NN denotes regulation
T5736 13242-13245 CC denotes and
T5737 13246-13258 NN denotes heritability
T5738 13259-13261 IN denotes of
T5739 13262-13265 DT denotes the
T5740 13278-13283 NN denotes trait
T5741 13266-13273 JJ denotes gonadal
T5742 13274-13277 NN denotes fat
T5743 13284-13291 IN denotes between
T5744 13292-13295 DT denotes the
T5745 13296-13301 NNS denotes sexes
T5746 13301-13302 . denotes .
T7352 13304-13309 NN denotes Liver
T7353 13310-13315 NNS denotes eQTLs
T7354 13315-13542 sentence denotes Livers from 312 F2 animals (156 female, 156 male) were profiled using oligonucleotide microarrays manufactured by Agilent Technologies (Palo Alto, California, United States), which included probes for 23,574 mouse transcripts.
T7355 13316-13322 NNS denotes Livers
T7356 13371-13379 VBN denotes profiled
T7357 13323-13327 IN denotes from
T7358 13328-13331 CD denotes 312
T7359 13335-13342 NNS denotes animals
T7360 13332-13334 NN denotes F2
T7361 13343-13344 -LRB- denotes (
T7362 13344-13347 CD denotes 156
T7363 13348-13354 JJ denotes female
T7364 13354-13356 , denotes ,
T7365 13356-13359 CD denotes 156
T7366 13360-13364 JJ denotes male
T7367 13364-13365 -RRB- denotes )
T7368 13366-13370 VBD denotes were
T7369 13380-13385 VBG denotes using
T7370 13386-13401 NN denotes oligonucleotide
T7371 13402-13413 NNS denotes microarrays
T7372 13414-13426 VBN denotes manufactured
T7373 13427-13429 IN denotes by
T7374 13430-13437 NNP denotes Agilent
T7375 13438-13450 NNP denotes Technologies
T7376 13451-13452 -LRB- denotes (
T7377 13457-13461 NNP denotes Alto
T7378 13452-13456 NNP denotes Palo
T7379 13461-13463 , denotes ,
T7380 13463-13473 NNP denotes California
T7381 13473-13475 , denotes ,
T7382 13475-13481 NNP denotes United
T7383 13482-13488 NNP denotes States
T7384 13488-13489 -RRB- denotes )
T7385 13489-13491 , denotes ,
T7386 13491-13496 WDT denotes which
T7387 13497-13505 VBD denotes included
T7388 13506-13512 NNS denotes probes
T7389 13513-13516 IN denotes for
T7390 13517-13523 CD denotes 23,574
T7391 13530-13541 NNS denotes transcripts
T7392 13524-13529 NN denotes mouse
T7393 13541-13542 . denotes .
T7394 13542-13799 sentence denotes Individual transcript intensities were corrected for experimental variation and normalized and are reported as the mean log10 ratio (mlratio) of an individual experiment relative to a pool composed of 150 mice randomly selected from the F2 population [21].
T7395 13543-13553 JJ denotes Individual
T7396 13565-13576 NNS denotes intensities
T7397 13554-13564 NN denotes transcript
T7398 13582-13591 VBN denotes corrected
T7399 13577-13581 VBD denotes were
T7400 13592-13595 IN denotes for
T7401 13596-13608 JJ denotes experimental
T7402 13609-13618 NN denotes variation
T7403 13619-13622 CC denotes and
T7404 13623-13633 VBN denotes normalized
T7405 13634-13637 CC denotes and
T7406 13638-13641 VBP denotes are
T7407 13642-13650 VBN denotes reported
T7408 13651-13653 IN denotes as
T7409 13654-13657 DT denotes the
T7410 13669-13674 NN denotes ratio
T7411 13658-13662 NN denotes mean
T7412 13663-13668 NN denotes log10
T7413 13675-13676 -LRB- denotes (
T7414 13676-13683 NN denotes mlratio
T7415 13683-13684 -RRB- denotes )
T7416 13685-13687 IN denotes of
T7417 13688-13690 DT denotes an
T7418 13702-13712 NN denotes experiment
T7419 13691-13701 JJ denotes individual
T7420 13713-13721 JJ denotes relative
T7421 13722-13724 IN denotes to
T7422 13725-13726 DT denotes a
T7423 13727-13731 NN denotes pool
T7424 13732-13740 VBN denotes composed
T7425 13741-13743 IN denotes of
T7426 13744-13747 CD denotes 150
T7427 13748-13752 NNS denotes mice
T7428 13753-13761 RB denotes randomly
T7429 13762-13770 VBN denotes selected
T7430 13771-13775 IN denotes from
T7431 13776-13779 DT denotes the
T7432 13783-13793 NN denotes population
T7433 13780-13782 NN denotes F2
T7434 13794-13795 -LRB- denotes [
T7435 13795-13797 CD denotes 21
T7436 13797-13798 -RRB- denotes ]
T7437 13798-13799 . denotes .
T7438 13799-13901 sentence denotes Each measurement was fitted to an error model and assigned a significance measurement (type I error).
T7439 13800-13804 DT denotes Each
T7440 13805-13816 NN denotes measurement
T7441 13821-13827 VBN denotes fitted
T7442 13817-13820 VBD denotes was
T7443 13828-13830 IN denotes to
T7444 13831-13833 DT denotes an
T7445 13840-13845 NN denotes model
T7446 13834-13839 NN denotes error
T7447 13846-13849 CC denotes and
T7448 13850-13858 VBD denotes assigned
T7449 13859-13860 DT denotes a
T7450 13874-13885 NN denotes measurement
T7451 13861-13873 NN denotes significance
T7452 13886-13887 -LRB- denotes (
T7453 13894-13899 NN denotes error
T7454 13887-13891 NN denotes type
T7455 13892-13893 CD denotes I
T7456 13899-13900 -RRB- denotes )
T7457 13900-13901 . denotes .
T7458 13901-14050 sentence denotes A heat map of the 2,320 transcripts most differentially expressed (p < 0.05 in 10% or more of animals) relative to the pool is depicted in Figure 3.
T7459 13902-13903 DT denotes A
T7460 13909-13912 NN denotes map
T7461 13904-13908 NN denotes heat
T7462 14029-14037 VBN denotes depicted
T7463 13913-13915 IN denotes of
T7464 13916-13919 DT denotes the
T7465 13926-13937 NNS denotes transcripts
T7466 13920-13925 CD denotes 2,320
T7467 13938-13942 RBS denotes most
T7468 13943-13957 RB denotes differentially
T7469 13958-13967 VBN denotes expressed
T7470 13968-13969 -LRB- denotes (
T7471 13973-13977 CD denotes 0.05
T7472 13969-13970 NN denotes p
T7473 13971-13972 SYM denotes <
T7474 13978-13980 IN denotes in
T7475 13981-13983 CD denotes 10
T7476 13983-13984 NN denotes %
T7477 13985-13987 CC denotes or
T7478 13988-13992 JJR denotes more
T7479 13993-13995 IN denotes of
T7480 13996-14003 NNS denotes animals
T7481 14003-14004 -RRB- denotes )
T7482 14005-14013 JJ denotes relative
T7483 14014-14016 IN denotes to
T7484 14017-14020 DT denotes the
T7485 14021-14025 NN denotes pool
T7486 14026-14028 VBZ denotes is
T7487 14038-14040 IN denotes in
T7488 14041-14047 NN denotes Figure
T7489 14048-14049 CD denotes 3
T7490 14049-14050 . denotes .
T7491 14050-14201 sentence denotes This selection of genes was not biased on a priori known differential expression between the sexes, linkage, or correlation with a clinical phenotype.
T7492 14051-14055 DT denotes This
T7493 14056-14065 NN denotes selection
T7494 14075-14078 VBD denotes was
T7495 14066-14068 IN denotes of
T7496 14069-14074 NNS denotes genes
T7497 14079-14082 RB denotes not
T7498 14083-14089 JJ denotes biased
T7499 14090-14092 IN denotes on
T7500 14093-14094 FW denotes a
T7501 14095-14101 FW denotes priori
T7502 14121-14131 NN denotes expression
T7503 14102-14107 JJ denotes known
T7504 14108-14120 JJ denotes differential
T7505 14132-14139 IN denotes between
T7506 14140-14143 DT denotes the
T7507 14144-14149 NNS denotes sexes
T7508 14149-14151 , denotes ,
T7509 14151-14158 NN denotes linkage
T7510 14158-14160 , denotes ,
T7511 14160-14162 CC denotes or
T7512 14163-14174 NN denotes correlation
T7513 14175-14179 IN denotes with
T7514 14180-14181 DT denotes a
T7515 14191-14200 NN denotes phenotype
T7516 14182-14190 JJ denotes clinical
T7517 14200-14201 . denotes .
T7518 14201-14544 sentence denotes This is noteworthy because hierarchical clustering of these transcripts against the 312 F2 mice shows an almost perfect clustering into male and female subgroups, emphasizing striking effects of sex on liver gene expression levels and suggesting that sex is controlling more variance in these transcripts' expression than any other parameter.
T7519 14202-14206 DT denotes This
T7520 14207-14209 VBZ denotes is
T7521 14210-14220 JJ denotes noteworthy
T7522 14221-14228 IN denotes because
T7523 14298-14303 VBZ denotes shows
T7524 14229-14241 JJ denotes hierarchical
T7525 14242-14252 NN denotes clustering
T7526 14253-14255 IN denotes of
T7527 14256-14261 DT denotes these
T7528 14262-14273 NNS denotes transcripts
T7529 14274-14281 IN denotes against
T7530 14282-14285 DT denotes the
T7531 14293-14297 NNS denotes mice
T7532 14286-14289 CD denotes 312
T7533 14290-14292 NN denotes F2
T7534 14304-14306 DT denotes an
T7535 14322-14332 NN denotes clustering
T7536 14307-14313 RB denotes almost
T7537 14314-14321 JJ denotes perfect
T7538 14333-14337 IN denotes into
T7539 14338-14342 JJ denotes male
T7540 14354-14363 NNS denotes subgroups
T7541 14343-14346 CC denotes and
T7542 14347-14353 JJ denotes female
T7543 14363-14365 , denotes ,
T7544 14365-14376 VBG denotes emphasizing
T7545 14377-14385 JJ denotes striking
T7546 14386-14393 NNS denotes effects
T7547 14394-14396 IN denotes of
T7548 14397-14400 NN denotes sex
T7549 14401-14403 IN denotes on
T7550 14404-14409 NN denotes liver
T7551 14426-14432 NNS denotes levels
T7552 14410-14414 NN denotes gene
T7553 14415-14425 NN denotes expression
T7554 14433-14436 CC denotes and
T7555 14437-14447 VBG denotes suggesting
T7556 14448-14452 IN denotes that
T7557 14460-14471 VBG denotes controlling
T7558 14453-14456 NN denotes sex
T7559 14457-14459 VBZ denotes is
T7560 14472-14476 JJR denotes more
T7561 14477-14485 NN denotes variance
T7562 14486-14488 IN denotes in
T7563 14489-14494 DT denotes these
T7564 14495-14506 NNS denotes transcripts
T7565 14508-14518 NN denotes expression
T7566 14506-14507 POS denotes '
T7567 14519-14523 IN denotes than
T7568 14524-14527 DT denotes any
T7569 14534-14543 NN denotes parameter
T7570 14528-14533 JJ denotes other
T7571 14543-14544 . denotes .
T7572 14544-15060 sentence denotes Figure 3 Heat Map of Liver Gene Expression Over 2,300 of the most differentially expressed genes in liver hierarchically clustered by animals (x-axis) against transcript levels (y-axis). Expression is reported as mlratio of individual experiment against a common pool. Red is over- and green underrepresented relative to pool. The expression values of the 23,574 transcripts were treated as quantitative traits and fitted to the same linear regression models used to compute LOD scores for clinical traits (eQTLs).
T7573 14873-14876 DT denotes The
T7574 14888-14894 NNS denotes values
T7575 14877-14887 NN denotes expression
T7576 14926-14933 VBN denotes treated
T7577 14895-14897 IN denotes of
T7578 14898-14901 DT denotes the
T7579 14909-14920 NNS denotes transcripts
T7580 14902-14908 CD denotes 23,574
T7581 14921-14925 VBD denotes were
T7582 14934-14936 IN denotes as
T7583 14937-14949 JJ denotes quantitative
T7584 14950-14956 NNS denotes traits
T7585 14957-14960 CC denotes and
T7586 14961-14967 VBN denotes fitted
T7587 14968-14970 IN denotes to
T7588 14971-14974 DT denotes the
T7589 14998-15004 NNS denotes models
T7590 14975-14979 JJ denotes same
T7591 14980-14986 JJ denotes linear
T7592 14987-14997 NN denotes regression
T7593 15005-15009 VBN denotes used
T7594 15010-15012 TO denotes to
T7595 15013-15020 VB denotes compute
T7596 15021-15024 NN denotes LOD
T7597 15025-15031 NNS denotes scores
T7598 15032-15035 IN denotes for
T7599 15036-15044 JJ denotes clinical
T7600 15045-15051 NNS denotes traits
T7601 15052-15053 -LRB- denotes (
T7602 15053-15058 NNS denotes eQTLs
T7603 15058-15059 -RRB- denotes )
T7604 15059-15060 . denotes .
T7605 15060-15332 sentence denotes The FDR at each threshold was determined by permuting the data 100 times and taking the mean number of QTLs detected over all of the permuted datasets at a given threshold, and dividing this count by the number of QTLs detected at the same threshold in the observed data.
T7606 15061-15064 DT denotes The
T7607 15065-15068 NN denotes FDR
T7608 15091-15101 VBN denotes determined
T7609 15069-15071 IN denotes at
T7610 15072-15076 DT denotes each
T7611 15077-15086 NN denotes threshold
T7612 15087-15090 VBD denotes was
T7613 15102-15104 IN denotes by
T7614 15105-15114 VBG denotes permuting
T7615 15115-15118 DT denotes the
T7616 15119-15123 NNS denotes data
T7617 15124-15127 CD denotes 100
T7618 15128-15133 NNS denotes times
T7619 15134-15137 CC denotes and
T7620 15138-15144 VBG denotes taking
T7621 15145-15148 DT denotes the
T7622 15154-15160 NN denotes number
T7623 15149-15153 NN denotes mean
T7624 15161-15163 IN denotes of
T7625 15164-15168 NNS denotes QTLs
T7626 15169-15177 VBN denotes detected
T7627 15178-15182 IN denotes over
T7628 15183-15186 DT denotes all
T7629 15187-15189 IN denotes of
T7630 15190-15193 DT denotes the
T7631 15203-15211 NNS denotes datasets
T7632 15194-15202 VBN denotes permuted
T7633 15212-15214 IN denotes at
T7634 15215-15216 DT denotes a
T7635 15223-15232 NN denotes threshold
T7636 15217-15222 JJ denotes given
T7637 15232-15234 , denotes ,
T7638 15234-15237 CC denotes and
T7639 15238-15246 VBG denotes dividing
T7640 15247-15251 DT denotes this
T7641 15252-15257 NN denotes count
T7642 15258-15260 IN denotes by
T7643 15261-15264 DT denotes the
T7644 15265-15271 NN denotes number
T7645 15272-15274 IN denotes of
T7646 15275-15279 NNS denotes QTLs
T7647 15280-15288 VBN denotes detected
T7648 15289-15291 IN denotes at
T7649 15292-15295 DT denotes the
T7650 15301-15310 NN denotes threshold
T7651 15296-15300 JJ denotes same
T7652 15311-15313 IN denotes in
T7653 15314-15317 DT denotes the
T7654 15327-15331 NNS denotes data
T7655 15318-15326 VBN denotes observed
T7656 15331-15332 . denotes .
T7657 15332-15713 sentence denotes At the threshold for significant linkage (p < 5 × 10−5, genome-wide p < 0.05, based on a single trait), the FDR was estimated at 3.4% for the standard QTL model not accounting for any sex terms, 3.1% for the QTL model accounting for additive sex effects, and 3.2% for the QTL model accounting for additive sex effects and allowing for the sex interaction terms to enter the model.
T7658 15333-15335 IN denotes At
T7659 15449-15458 VBN denotes estimated
T7660 15336-15339 DT denotes the
T7661 15340-15349 NN denotes threshold
T7662 15350-15353 IN denotes for
T7663 15354-15365 JJ denotes significant
T7664 15366-15373 NN denotes linkage
T7665 15374-15375 -LRB- denotes (
T7666 15405-15409 CD denotes 0.05
T7667 15375-15376 NN denotes p
T7668 15379-15380 CD denotes 5
T7669 15377-15378 SYM denotes <
T7670 15381-15382 SYM denotes ×
T7671 15383-15385 CD denotes 10
T7672 15386-15387 CD denotes 5
T7673 15385-15386 SYM denotes −
T7674 15387-15389 , denotes ,
T7675 15389-15395 NN denotes genome
T7676 15401-15402 NN denotes p
T7677 15395-15396 HYPH denotes -
T7678 15396-15400 JJ denotes wide
T7679 15403-15404 SYM denotes <
T7680 15409-15411 , denotes ,
T7681 15411-15416 VBN denotes based
T7682 15417-15419 IN denotes on
T7683 15420-15421 DT denotes a
T7684 15429-15434 NN denotes trait
T7685 15422-15428 JJ denotes single
T7686 15434-15435 -RRB- denotes )
T7687 15435-15437 , denotes ,
T7688 15437-15440 DT denotes the
T7689 15441-15444 NN denotes FDR
T7690 15445-15448 VBD denotes was
T7691 15459-15461 IN denotes at
T7692 15462-15465 CD denotes 3.4
T7693 15465-15466 NN denotes %
T7694 15467-15470 IN denotes for
T7695 15471-15474 DT denotes the
T7696 15488-15493 NN denotes model
T7697 15475-15483 JJ denotes standard
T7698 15484-15487 NN denotes QTL
T7699 15494-15497 RB denotes not
T7700 15498-15508 VBG denotes accounting
T7701 15509-15512 IN denotes for
T7702 15513-15516 DT denotes any
T7703 15521-15526 NNS denotes terms
T7704 15517-15520 NN denotes sex
T7705 15526-15528 , denotes ,
T7706 15528-15531 CD denotes 3.1
T7707 15531-15532 NN denotes %
T7708 15533-15536 IN denotes for
T7709 15537-15540 DT denotes the
T7710 15545-15550 NN denotes model
T7711 15541-15544 NN denotes QTL
T7712 15551-15561 VBG denotes accounting
T7713 15562-15565 IN denotes for
T7714 15566-15574 JJ denotes additive
T7715 15579-15586 NNS denotes effects
T7716 15575-15578 NN denotes sex
T7717 15586-15588 , denotes ,
T7718 15588-15591 CC denotes and
T7719 15592-15595 CD denotes 3.2
T7720 15595-15596 NN denotes %
T7721 15597-15600 IN denotes for
T7722 15601-15604 DT denotes the
T7723 15609-15614 NN denotes model
T7724 15605-15608 NN denotes QTL
T7725 15615-15625 VBG denotes accounting
T7726 15626-15629 IN denotes for
T7727 15630-15638 JJ denotes additive
T7728 15643-15650 NNS denotes effects
T7729 15639-15642 NN denotes sex
T7730 15651-15654 CC denotes and
T7731 15655-15663 VBG denotes allowing
T7732 15664-15667 IN denotes for
T7733 15697-15702 VB denotes enter
T7734 15668-15671 DT denotes the
T7735 15688-15693 NNS denotes terms
T7736 15672-15675 NN denotes sex
T7737 15676-15687 NN denotes interaction
T7738 15694-15696 TO denotes to
T7739 15703-15706 DT denotes the
T7740 15707-15712 NN denotes model
T7741 15712-15713 . denotes .
T7742 15713-15863 sentence denotes A list of all detected suggestive (p < 1 × 10−3) and significant eQTLs (p < 5 × 10−5) detected in the BXH.ApoE−/− intercross is provided in Table S1.
T7743 15714-15715 DT denotes A
T7744 15716-15720 NN denotes list
T7745 15842-15850 VBN denotes provided
T7746 15721-15723 IN denotes of
T7747 15724-15727 DT denotes all
T7748 15779-15784 NNS denotes eQTLs
T7749 15728-15736 VBN denotes detected
T7750 15737-15747 JJ denotes suggestive
T7751 15748-15749 -LRB- denotes (
T7752 15760-15761 CD denotes 3
T7753 15749-15750 NN denotes p
T7754 15751-15752 SYM denotes <
T7755 15753-15754 CD denotes 1
T7756 15755-15756 SYM denotes ×
T7757 15757-15759 CD denotes 10
T7758 15759-15760 SYM denotes −
T7759 15761-15762 -RRB- denotes )
T7760 15763-15766 CC denotes and
T7761 15767-15778 JJ denotes significant
T7762 15785-15786 -LRB- denotes (
T7763 15797-15798 CD denotes 5
T7764 15786-15787 NN denotes p
T7765 15788-15789 SYM denotes <
T7766 15790-15791 CD denotes 5
T7767 15792-15793 SYM denotes ×
T7768 15794-15796 CD denotes 10
T7769 15796-15797 SYM denotes −
T7770 15798-15799 -RRB- denotes )
T7771 15800-15808 VBN denotes detected
T7772 15809-15811 IN denotes in
T7773 15812-15815 DT denotes the
T7774 15828-15838 NN denotes intercross
T7775 15816-15824 NN denotes BXH.ApoE
T7776 15824-15825 SYM denotes −
T7777 15825-15826 HYPH denotes /
T7778 15826-15827 SYM denotes −
T7779 15839-15841 VBZ denotes is
T7780 15851-15853 IN denotes in
T7781 15854-15859 NN denotes Table
T7782 15860-15862 NN denotes S1
T7783 15862-15863 . denotes .
T7784 15863-15986 sentence denotes Characteristics of the eQTLs at different significance levels are summarized in Table 3 and shown graphically in Figure 4.
T7785 15864-15879 NNS denotes Characteristics
T7786 15930-15940 VBN denotes summarized
T7787 15880-15882 IN denotes of
T7788 15883-15886 DT denotes the
T7789 15887-15892 NNS denotes eQTLs
T7790 15893-15895 IN denotes at
T7791 15896-15905 JJ denotes different
T7792 15919-15925 NNS denotes levels
T7793 15906-15918 NN denotes significance
T7794 15926-15929 VBP denotes are
T7795 15941-15943 IN denotes in
T7796 15944-15949 NN denotes Table
T7797 15950-15951 CD denotes 3
T7798 15952-15955 CC denotes and
T7799 15956-15961 VBN denotes shown
T7800 15962-15973 RB denotes graphically
T7801 15974-15976 IN denotes in
T7802 15977-15983 NN denotes Figure
T7803 15984-15985 CD denotes 4
T7804 15985-15986 . denotes .
T7805 15986-16076 sentence denotes We detected 6,676 eQTLs representing 4,998 transcripts at the 5 × 10−5 significant level.
T7806 15987-15989 PRP denotes We
T7807 15990-15998 VBD denotes detected
T7808 15999-16004 CD denotes 6,676
T7809 16005-16010 NNS denotes eQTLs
T7810 16011-16023 VBG denotes representing
T7811 16024-16029 CD denotes 4,998
T7812 16030-16041 NNS denotes transcripts
T7813 16042-16044 IN denotes at
T7814 16045-16048 DT denotes the
T7815 16070-16075 NN denotes level
T7816 16049-16050 CD denotes 5
T7817 16051-16052 SYM denotes ×
T7818 16053-16055 CD denotes 10
T7819 16056-16057 CD denotes 5
T7820 16055-16056 SYM denotes −
T7821 16058-16069 JJ denotes significant
T7822 16075-16076 . denotes .
T7823 16076-16251 sentence denotes Of these, 2,118 eQTLs were located within 20 Mb (roughly 10 cM) of the corresponding gene, likely representing eQTLs regulated by cis-acting variation within the gene itself.
T7824 16077-16079 IN denotes Of
T7825 16104-16111 VBN denotes located
T7826 16080-16085 DT denotes these
T7827 16085-16087 , denotes ,
T7828 16087-16092 CD denotes 2,118
T7829 16093-16098 NNS denotes eQTLs
T7830 16099-16103 VBD denotes were
T7831 16112-16118 IN denotes within
T7832 16119-16121 CD denotes 20
T7833 16122-16124 NN denotes Mb
T7834 16125-16126 -LRB- denotes (
T7835 16126-16133 RB denotes roughly
T7836 16134-16136 CD denotes 10
T7837 16137-16139 NN denotes cM
T7838 16139-16140 -RRB- denotes )
T7839 16141-16143 IN denotes of
T7840 16144-16147 DT denotes the
T7841 16162-16166 NN denotes gene
T7842 16148-16161 VBG denotes corresponding
T7843 16166-16168 , denotes ,
T7844 16168-16174 RB denotes likely
T7845 16175-16187 VBG denotes representing
T7846 16188-16193 NNS denotes eQTLs
T7847 16194-16203 VBN denotes regulated
T7848 16204-16206 IN denotes by
T7849 16207-16210 NN denotes cis
T7850 16211-16217 VBG denotes acting
T7851 16210-16211 HYPH denotes -
T7852 16218-16227 NN denotes variation
T7853 16228-16234 IN denotes within
T7854 16235-16238 DT denotes the
T7855 16239-16243 NN denotes gene
T7856 16244-16250 PRP denotes itself
T7857 16250-16251 . denotes .
T7858 16251-16426 sentence denotes Of the 6,676 significant eQTLs, 1,166 (17%) demonstrated a sex bias and were subsequently significantly improved with the addition of the sex-additive and sex-dominant terms.
T7859 16252-16254 IN denotes Of
T7860 16296-16308 VBD denotes demonstrated
T7861 16255-16258 DT denotes the
T7862 16277-16282 NNS denotes eQTLs
T7863 16259-16264 CD denotes 6,676
T7864 16265-16276 JJ denotes significant
T7865 16282-16284 , denotes ,
T7866 16284-16289 CD denotes 1,166
T7867 16290-16291 -LRB- denotes (
T7868 16293-16294 NN denotes %
T7869 16291-16293 CD denotes 17
T7870 16294-16295 -RRB- denotes )
T7871 16309-16310 DT denotes a
T7872 16315-16319 NN denotes bias
T7873 16311-16314 NN denotes sex
T7874 16320-16323 CC denotes and
T7875 16324-16328 VBD denotes were
T7876 16356-16364 VBN denotes improved
T7877 16329-16341 RB denotes subsequently
T7878 16342-16355 RB denotes significantly
T7879 16365-16369 IN denotes with
T7880 16370-16373 DT denotes the
T7881 16374-16382 NN denotes addition
T7882 16383-16385 IN denotes of
T7883 16386-16389 DT denotes the
T7884 16420-16425 NNS denotes terms
T7885 16390-16393 NN denotes sex
T7886 16394-16402 JJ denotes additive
T7887 16393-16394 HYPH denotes -
T7888 16403-16406 CC denotes and
T7889 16407-16410 NN denotes sex
T7890 16411-16419 JJ denotes dominant
T7891 16410-16411 HYPH denotes -
T7892 16425-16426 . denotes .
T7893 16426-17825 sentence denotes Table 3 Characteristics of Liver eQTLs Figure 4 Properties of All Liver eQTLs (A) Distribution of all significant liver eQTLs across the genome in 2-cM bins. A total of 6,676 significant eQTLs were realized, representing 4,998 liver transcripts. Hotspots of nonrandom eQTL colocalization are clearly evident. (B) Distribution of eQTLs with significant sex-specific effects. A total of 1,166 eQTLs representing 1,044 transcripts show an eQTL hotspot on Chromosome 5. (C) Properties of eQTLs at increasing significance levels. As the threshold for significant linkage increases (p-value decreases, or LOD score increases), the proportion of cis-eQTLs (black) increases. The fraction of all eQTLs with sex effects (red) and cis-eQTLs with sex effects (blue) remains relatively constant at increasing thresholds. The dashed line indicates the genome-wide significance threshold (p < 5 × 10−5; genome-wide p < 0.05). (D) Properties of sex-specific eQTLs at increasing significance levels. For eQTLs with significant sex effects, as with all eQTLs, the proportion of cis-eQTLs (black) increases and trans (blue) decreases as the threshold for significance increases. At the genome-wide threshold for significance (dashed line), over 70% of eQTLs with significant sex effects are trans. The distribution of all 6,676 significant eQTLs (p < 5 × 10−5) across the genome in 2 cM bins is shown in Figure 4A.
T7894 16427-17712 DT denotes Table 3 Characteristics of Liver eQTLs Figure 4 Properties of All Liver eQTLs (A) Distribution of all significant liver eQTLs across the genome in 2-cM bins. A total of 6,676 significant eQTLs were realized, representing 4,998 liver transcripts. Hotspots of nonrandom eQTL colocalization are clearly evident. (B) Distribution of eQTLs with significant sex-specific effects. A total of 1,166 eQTLs representing 1,044 transcripts show an eQTL hotspot on Chromosome 5. (C) Properties of eQTLs at increasing significance levels. As the threshold for significant linkage increases (p-value decreases, or LOD score increases), the proportion of cis-eQTLs (black) increases. The fraction of all eQTLs with sex effects (red) and cis-eQTLs with sex effects (blue) remains relatively constant at increasing thresholds. The dashed line indicates the genome-wide significance threshold (p < 5 × 10−5; genome-wide p < 0.05). (D) Properties of sex-specific eQTLs at increasing significance levels. For eQTLs with significant sex effects, as with all eQTLs, the proportion of cis-eQTLs (black) increases and trans (blue) decreases as the threshold for significance increases. At the genome-wide threshold for significance (dashed line), over 70% of eQTLs with significant sex effects are trans. The
T7895 17713-17725 NN denotes distribution
T7896 17806-17811 VBN denotes shown
T7897 17726-17728 IN denotes of
T7898 17729-17732 DT denotes all
T7899 17751-17756 NNS denotes eQTLs
T7900 17733-17738 CD denotes 6,676
T7901 17739-17750 JJ denotes significant
T7902 17757-17758 -LRB- denotes (
T7903 17762-17763 CD denotes 5
T7904 17758-17759 NN denotes p
T7905 17760-17761 SYM denotes <
T7906 17764-17765 SYM denotes ×
T7907 17766-17768 CD denotes 10
T7908 17769-17770 CD denotes 5
T7909 17768-17769 SYM denotes −
T7910 17770-17771 -RRB- denotes )
T7911 17772-17778 IN denotes across
T7912 17779-17782 DT denotes the
T7913 17783-17789 NN denotes genome
T7914 17790-17792 IN denotes in
T7915 17793-17794 CD denotes 2
T7916 17795-17797 NN denotes cM
T7917 17798-17802 NNS denotes bins
T7918 17803-17805 VBZ denotes is
T7919 17812-17814 IN denotes in
T7920 17815-17821 NN denotes Figure
T7921 17822-17824 NN denotes 4A
T7922 17824-17825 . denotes .
T7923 17825-17995 sentence denotes Evidence for eQTL hotspots is clear on Chromosomes 1, 2, 4, 5, 6, and 7 where significant fractions of the 6,676 eQTLs colocalize within 2 cM regions on each chromosome.
T7924 17826-17834 NN denotes Evidence
T7925 17853-17855 VBZ denotes is
T7926 17835-17838 IN denotes for
T7927 17839-17843 NN denotes eQTL
T7928 17844-17852 NNS denotes hotspots
T7929 17856-17861 JJ denotes clear
T7930 17862-17864 IN denotes on
T7931 17865-17876 NNS denotes Chromosomes
T7932 17877-17878 CD denotes 1
T7933 17878-17880 , denotes ,
T7934 17880-17881 CD denotes 2
T7935 17881-17883 , denotes ,
T7936 17883-17884 CD denotes 4
T7937 17884-17886 , denotes ,
T7938 17886-17887 CD denotes 5
T7939 17887-17889 , denotes ,
T7940 17889-17890 CD denotes 6
T7941 17890-17892 , denotes ,
T7942 17892-17895 CC denotes and
T7943 17896-17897 CD denotes 7
T7944 17898-17903 WRB denotes where
T7945 17945-17955 VBP denotes colocalize
T7946 17904-17915 JJ denotes significant
T7947 17916-17925 NNS denotes fractions
T7948 17926-17928 IN denotes of
T7949 17929-17932 DT denotes the
T7950 17939-17944 NNS denotes eQTLs
T7951 17933-17938 CD denotes 6,676
T7952 17956-17962 IN denotes within
T7953 17963-17964 CD denotes 2
T7954 17965-17967 NN denotes cM
T7955 17968-17975 NNS denotes regions
T7956 17976-17978 IN denotes on
T7957 17979-17983 DT denotes each
T7958 17984-17994 NN denotes chromosome
T7959 17994-17995 . denotes .
T7960 17995-18147 sentence denotes Approximately 67% of eQTLs at this threshold are trans, and these eQTL hotspots consist primarily of trans-acting effects on transcriptional variation.
T7961 17996-18009 RB denotes Approximately
T7962 18010-18012 CD denotes 67
T7963 18012-18013 NN denotes %
T7964 18041-18044 VBP denotes are
T7965 18014-18016 IN denotes of
T7966 18017-18022 NNS denotes eQTLs
T7967 18023-18025 IN denotes at
T7968 18026-18030 DT denotes this
T7969 18031-18040 NN denotes threshold
T7970 18045-18050 NN denotes trans
T7971 18050-18052 , denotes ,
T7972 18052-18055 CC denotes and
T7973 18056-18061 DT denotes these
T7974 18067-18075 NNS denotes hotspots
T7975 18062-18066 NN denotes eQTL
T7976 18076-18083 VBP denotes consist
T7977 18084-18093 RB denotes primarily
T7978 18094-18096 IN denotes of
T7979 18097-18102 NN denotes trans
T7980 18103-18109 VBG denotes acting
T7981 18102-18103 HYPH denotes -
T7982 18110-18117 NNS denotes effects
T7983 18118-18120 IN denotes on
T7984 18121-18136 JJ denotes transcriptional
T7985 18137-18146 NN denotes variation
T7986 18146-18147 . denotes .
T7987 18147-18395 sentence denotes Distribution of the 1,166 eQTLs with significant sex effects, of which 852 (73%) are trans, showed enrichment on Chromosome 5 at approximately 49 cM (Figure 4B) as assessed using the Fisher exact test (p = 8.7 × 10−25 after Bonferroni correction).
T7988 18148-18160 NN denotes Distribution
T7989 18240-18246 VBD denotes showed
T7990 18161-18163 IN denotes of
T7991 18164-18167 DT denotes the
T7992 18174-18179 NNS denotes eQTLs
T7993 18168-18173 CD denotes 1,166
T7994 18180-18184 IN denotes with
T7995 18185-18196 JJ denotes significant
T7996 18201-18208 NNS denotes effects
T7997 18197-18200 NN denotes sex
T7998 18208-18210 , denotes ,
T7999 18210-18212 IN denotes of
T8000 18229-18232 VBP denotes are
T8001 18213-18218 WDT denotes which
T8002 18219-18222 CD denotes 852
T8003 18223-18224 -LRB- denotes (
T8004 18226-18227 NN denotes %
T8005 18224-18226 CD denotes 73
T8006 18227-18228 -RRB- denotes )
T8007 18233-18238 NN denotes trans
T8008 18238-18240 , denotes ,
T8009 18247-18257 NN denotes enrichment
T8010 18258-18260 IN denotes on
T8011 18261-18271 NN denotes Chromosome
T8012 18272-18273 CD denotes 5
T8013 18274-18276 IN denotes at
T8014 18277-18290 RB denotes approximately
T8015 18291-18293 CD denotes 49
T8016 18294-18296 NN denotes cM
T8017 18297-18298 -LRB- denotes (
T8018 18305-18307 NN denotes 4B
T8019 18298-18304 NN denotes Figure
T8020 18307-18308 -RRB- denotes )
T8021 18309-18311 IN denotes as
T8022 18312-18320 VBN denotes assessed
T8023 18321-18326 VBG denotes using
T8024 18327-18330 DT denotes the
T8025 18344-18348 NN denotes test
T8026 18331-18337 NNP denotes Fisher
T8027 18338-18343 JJ denotes exact
T8028 18349-18350 -LRB- denotes (
T8029 18354-18357 CD denotes 8.7
T8030 18350-18351 NN denotes p
T8031 18352-18353 SYM denotes =
T8032 18358-18359 SYM denotes ×
T8033 18360-18362 CD denotes 10
T8034 18363-18365 CD denotes 25
T8035 18362-18363 SYM denotes −
T8036 18366-18371 IN denotes after
T8037 18372-18382 NNP denotes Bonferroni
T8038 18383-18393 NN denotes correction
T8039 18393-18394 -RRB- denotes )
T8040 18394-18395 . denotes .
T8041 18395-18481 sentence denotes At this locus there were 250 eQTLs, 140 of which exhibited genotype–sex interactions.
T8042 18396-18398 IN denotes At
T8043 18416-18420 VBD denotes were
T8044 18399-18403 DT denotes this
T8045 18404-18409 NN denotes locus
T8046 18410-18415 EX denotes there
T8047 18421-18424 CD denotes 250
T8048 18425-18430 NNS denotes eQTLs
T8049 18430-18432 , denotes ,
T8050 18432-18435 CD denotes 140
T8051 18445-18454 VBD denotes exhibited
T8052 18436-18438 IN denotes of
T8053 18439-18444 WDT denotes which
T8054 18455-18463 NN denotes genotype
T8055 18464-18467 NN denotes sex
T8056 18463-18464 HYPH denotes –
T8057 18468-18480 NNS denotes interactions
T8058 18480-18481 . denotes .
T8059 18481-18584 sentence denotes At increasing thresholds for linkage, a higher fraction of detected eQTLs were cis-acting (Figure 4C).
T8060 18482-18484 IN denotes At
T8061 18556-18560 VBD denotes were
T8062 18485-18495 VBG denotes increasing
T8063 18496-18506 NNS denotes thresholds
T8064 18507-18510 IN denotes for
T8065 18511-18518 NN denotes linkage
T8066 18518-18520 , denotes ,
T8067 18520-18521 DT denotes a
T8068 18529-18537 NN denotes fraction
T8069 18522-18528 JJR denotes higher
T8070 18538-18540 IN denotes of
T8071 18541-18549 VBN denotes detected
T8072 18550-18555 NNS denotes eQTLs
T8073 18561-18564 NN denotes cis
T8074 18565-18571 VBG denotes acting
T8075 18564-18565 HYPH denotes -
T8076 18572-18573 -LRB- denotes (
T8077 18580-18582 NN denotes 4C
T8078 18573-18579 NN denotes Figure
T8079 18582-18583 -RRB- denotes )
T8080 18583-18584 . denotes .
T8081 18584-18814 sentence denotes The increased proportion of cis-eQTLs with increasing LOD score thresholds has been reported before [5,15] and confirms what is likely to be our increased power to detect first-order cis-acting variations affecting transcription.
T8082 18585-18588 DT denotes The
T8083 18599-18609 NN denotes proportion
T8084 18589-18598 VBN denotes increased
T8085 18669-18677 VBN denotes reported
T8086 18610-18612 IN denotes of
T8087 18613-18616 NN denotes cis
T8088 18617-18622 NNS denotes eQTLs
T8089 18616-18617 HYPH denotes -
T8090 18623-18627 IN denotes with
T8091 18628-18638 VBG denotes increasing
T8092 18649-18659 NNS denotes thresholds
T8093 18639-18642 NN denotes LOD
T8094 18643-18648 NN denotes score
T8095 18660-18663 VBZ denotes has
T8096 18664-18668 VBN denotes been
T8097 18678-18684 RB denotes before
T8098 18685-18686 -LRB- denotes [
T8099 18688-18690 CD denotes 15
T8100 18686-18687 CD denotes 5
T8101 18687-18688 , denotes ,
T8102 18690-18691 -RRB- denotes ]
T8103 18692-18695 CC denotes and
T8104 18696-18704 VBZ denotes confirms
T8105 18705-18709 WP denotes what
T8106 18710-18712 VBZ denotes is
T8107 18713-18719 JJ denotes likely
T8108 18720-18722 TO denotes to
T8109 18723-18725 VB denotes be
T8110 18726-18729 PRP$ denotes our
T8111 18740-18745 NN denotes power
T8112 18730-18739 VBN denotes increased
T8113 18746-18748 TO denotes to
T8114 18749-18755 VB denotes detect
T8115 18756-18761 JJ denotes first
T8116 18762-18767 NN denotes order
T8117 18761-18762 HYPH denotes -
T8118 18779-18789 NNS denotes variations
T8119 18768-18771 NN denotes cis
T8120 18772-18778 VBG denotes acting
T8121 18771-18772 HYPH denotes -
T8122 18790-18799 VBG denotes affecting
T8123 18800-18813 NN denotes transcription
T8124 18813-18814 . denotes .
T8125 18814-18927 sentence denotes The proportion of eQTLs with significant sex effects remained relatively constant at all thresholds (Figure 4C).
T8126 18815-18818 DT denotes The
T8127 18819-18829 NN denotes proportion
T8128 18868-18876 VBD denotes remained
T8129 18830-18832 IN denotes of
T8130 18833-18838 NNS denotes eQTLs
T8131 18839-18843 IN denotes with
T8132 18844-18855 JJ denotes significant
T8133 18860-18867 NNS denotes effects
T8134 18856-18859 NN denotes sex
T8135 18877-18887 RB denotes relatively
T8136 18888-18896 JJ denotes constant
T8137 18897-18899 IN denotes at
T8138 18900-18903 DT denotes all
T8139 18904-18914 NNS denotes thresholds
T8140 18915-18916 -LRB- denotes (
T8141 18923-18925 NN denotes 4C
T8142 18916-18922 NN denotes Figure
T8143 18925-18926 -RRB- denotes )
T8144 18926-18927 . denotes .
T8145 18927-19166 sentence denotes Furthermore, the majority of these sex-specific eQTLs (73%) are acting in trans on a given gene's expression (Figure 4D), and similar proportions of sex-specific eQTLs (26%) are cis compared to the proportion of all liver cis-eQTLs (32%).
T8146 18928-18939 RB denotes Furthermore
T8147 18992-18998 VBG denotes acting
T8148 18939-18941 , denotes ,
T8149 18941-18944 DT denotes the
T8150 18945-18953 NN denotes majority
T8151 18954-18956 IN denotes of
T8152 18957-18962 DT denotes these
T8153 18976-18981 NNS denotes eQTLs
T8154 18963-18966 NN denotes sex
T8155 18967-18975 JJ denotes specific
T8156 18966-18967 HYPH denotes -
T8157 18982-18983 -LRB- denotes (
T8158 18985-18986 NN denotes %
T8159 18983-18985 CD denotes 73
T8160 18986-18987 -RRB- denotes )
T8161 18988-18991 VBP denotes are
T8162 18999-19001 IN denotes in
T8163 19002-19007 NN denotes trans
T8164 19008-19010 IN denotes on
T8165 19011-19012 DT denotes a
T8166 19019-19023 NN denotes gene
T8167 19013-19018 JJ denotes given
T8168 19026-19036 NN denotes expression
T8169 19023-19025 POS denotes 's
T8170 19037-19038 -LRB- denotes (
T8171 19045-19047 NN denotes 4D
T8172 19038-19044 NN denotes Figure
T8173 19047-19048 -RRB- denotes )
T8174 19048-19050 , denotes ,
T8175 19050-19053 CC denotes and
T8176 19054-19061 JJ denotes similar
T8177 19062-19073 NNS denotes proportions
T8178 19102-19105 VBP denotes are
T8179 19074-19076 IN denotes of
T8180 19077-19080 NN denotes sex
T8181 19081-19089 JJ denotes specific
T8182 19080-19081 HYPH denotes -
T8183 19090-19095 NNS denotes eQTLs
T8184 19096-19097 -LRB- denotes (
T8185 19099-19100 NN denotes %
T8186 19097-19099 CD denotes 26
T8187 19100-19101 -RRB- denotes )
T8188 19106-19109 NN denotes cis
T8189 19110-19118 VBN denotes compared
T8190 19119-19121 IN denotes to
T8191 19122-19125 DT denotes the
T8192 19126-19136 NN denotes proportion
T8193 19137-19139 IN denotes of
T8194 19140-19143 DT denotes all
T8195 19154-19159 NNS denotes eQTLs
T8196 19144-19149 NN denotes liver
T8197 19150-19153 NN denotes cis
T8198 19153-19154 HYPH denotes -
T8199 19160-19161 -LRB- denotes (
T8200 19163-19164 NN denotes %
T8201 19161-19163 CD denotes 32
T8202 19164-19165 -RRB- denotes )
T8203 19165-19166 . denotes .
T8204 19166-19263 sentence denotes These data demonstrate the profound effects of sex on the genetic regulation of gene expression.
T8205 19167-19172 DT denotes These
T8206 19173-19177 NNS denotes data
T8207 19178-19189 VBP denotes demonstrate
T8208 19190-19193 DT denotes the
T8209 19203-19210 NNS denotes effects
T8210 19194-19202 JJ denotes profound
T8211 19211-19213 IN denotes of
T8212 19214-19217 NN denotes sex
T8213 19218-19220 IN denotes on
T8214 19221-19224 DT denotes the
T8215 19233-19243 NN denotes regulation
T8216 19225-19232 JJ denotes genetic
T8217 19244-19246 IN denotes of
T8218 19247-19251 NN denotes gene
T8219 19252-19262 NN denotes expression
T8220 19262-19263 . denotes .
T8448 19265-19268 NN denotes Cis
T8449 19269-19274 NNS denotes eQTLs
T8450 19268-19269 HYPH denotes -
T8451 19275-19278 VBP denotes Are
T8452 19279-19288 NN denotes Candidate
T8453 19289-19294 NNS denotes Genes
T8454 19295-19298 IN denotes for
T8455 19299-19302 DT denotes the
T8456 19320-19325 NN denotes Trait
T8457 19303-19310 JJ denotes Gonadal
T8458 19315-19319 NN denotes Mass
T8459 19311-19314 NN denotes Fat
T8460 19325-19571 sentence denotes Given the marked effects of sex on liver gene expression and the genetic regulation of gonadal fat mass, we reasoned that cis-eQTLs with significant “sex-additive” and “sex-dominant” interactions would be potential candidate genes for our trait.
T8461 19326-19331 VBN denotes Given
T8462 19434-19442 VBD denotes reasoned
T8463 19332-19335 DT denotes the
T8464 19343-19350 NNS denotes effects
T8465 19336-19342 JJ denotes marked
T8466 19351-19353 IN denotes of
T8467 19354-19357 NN denotes sex
T8468 19358-19360 IN denotes on
T8469 19361-19366 NN denotes liver
T8470 19372-19382 NN denotes expression
T8471 19367-19371 NN denotes gene
T8472 19383-19386 CC denotes and
T8473 19387-19390 DT denotes the
T8474 19399-19409 NN denotes regulation
T8475 19391-19398 JJ denotes genetic
T8476 19410-19412 IN denotes of
T8477 19413-19420 JJ denotes gonadal
T8478 19425-19429 NN denotes mass
T8479 19421-19424 NN denotes fat
T8480 19429-19431 , denotes ,
T8481 19431-19433 PRP denotes we
T8482 19443-19447 IN denotes that
T8483 19528-19530 VB denotes be
T8484 19448-19451 NN denotes cis
T8485 19452-19457 NNS denotes eQTLs
T8486 19451-19452 HYPH denotes -
T8487 19458-19462 IN denotes with
T8488 19463-19474 JJ denotes significant
T8489 19509-19521 NNS denotes interactions
T8490 19475-19476 `` denotes “
T8491 19476-19479 NN denotes sex
T8492 19480-19488 JJ denotes additive
T8493 19479-19480 HYPH denotes -
T8494 19488-19489 '' denotes ”
T8495 19490-19493 CC denotes and
T8496 19494-19495 `` denotes “
T8497 19499-19507 JJ denotes dominant
T8498 19495-19498 NN denotes sex
T8499 19498-19499 HYPH denotes -
T8500 19507-19508 '' denotes ”
T8501 19522-19527 MD denotes would
T8502 19531-19540 JJ denotes potential
T8503 19551-19556 NNS denotes genes
T8504 19541-19550 NN denotes candidate
T8505 19557-19560 IN denotes for
T8506 19561-19564 PRP$ denotes our
T8507 19565-19570 NN denotes trait
T8508 19570-19571 . denotes .
T8509 19571-19661 sentence denotes Of the 2,118 significant cis-eQTLs, 304 (14%) were improved by the sex-interaction terms.
T8510 19572-19574 IN denotes Of
T8511 19623-19631 VBN denotes improved
T8512 19575-19578 DT denotes the
T8513 19601-19606 NNS denotes eQTLs
T8514 19579-19584 CD denotes 2,118
T8515 19585-19596 JJ denotes significant
T8516 19597-19600 NN denotes cis
T8517 19600-19601 HYPH denotes -
T8518 19606-19608 , denotes ,
T8519 19608-19611 CD denotes 304
T8520 19612-19613 -LRB- denotes (
T8521 19615-19616 NN denotes %
T8522 19613-19615 CD denotes 14
T8523 19616-19617 -RRB- denotes )
T8524 19618-19622 VBD denotes were
T8525 19632-19634 IN denotes by
T8526 19635-19638 DT denotes the
T8527 19655-19660 NNS denotes terms
T8528 19639-19642 NN denotes sex
T8529 19643-19654 NN denotes interaction
T8530 19642-19643 HYPH denotes -
T8531 19660-19661 . denotes .
T8532 19661-19764 sentence denotes Cis-eQTLs overlapping the confidence interval for the fat mass cQTL are candidate genes for the trait.
T8533 19662-19665 NN denotes Cis
T8534 19666-19671 NNS denotes eQTLs
T8535 19665-19666 HYPH denotes -
T8536 19730-19733 VBP denotes are
T8537 19672-19683 VBG denotes overlapping
T8538 19684-19687 DT denotes the
T8539 19699-19707 NN denotes interval
T8540 19688-19698 NN denotes confidence
T8541 19708-19711 IN denotes for
T8542 19712-19715 DT denotes the
T8543 19725-19729 NN denotes cQTL
T8544 19716-19719 NN denotes fat
T8545 19720-19724 NN denotes mass
T8546 19734-19743 NN denotes candidate
T8547 19744-19749 NNS denotes genes
T8548 19750-19753 IN denotes for
T8549 19754-19757 DT denotes the
T8550 19758-19763 NN denotes trait
T8551 19763-19764 . denotes .
T8552 19764-19884 sentence denotes Those genes with significant sex interactions receive increased consideration as potential candidates (Tables 4 and 5).
T8553 19765-19770 DT denotes Those
T8554 19771-19776 NNS denotes genes
T8555 19811-19818 VBP denotes receive
T8556 19777-19781 IN denotes with
T8557 19782-19793 JJ denotes significant
T8558 19798-19810 NNS denotes interactions
T8559 19794-19797 NN denotes sex
T8560 19819-19828 VBN denotes increased
T8561 19829-19842 NN denotes consideration
T8562 19843-19845 IN denotes as
T8563 19846-19855 JJ denotes potential
T8564 19856-19866 NNS denotes candidates
T8565 19867-19868 -LRB- denotes (
T8566 19875-19876 CD denotes 4
T8567 19868-19874 NNS denotes Tables
T8568 19877-19880 CC denotes and
T8569 19881-19882 CD denotes 5
T8570 19882-19883 -RRB- denotes )
T8571 19883-19884 . denotes .
T10517 20107-20116 NNS denotes Thousands
T10518 20126-20130 VBP denotes Show
T10519 20117-20119 IN denotes of
T10520 20120-20125 NNS denotes Genes
T10521 20131-20132 DT denotes a
T10522 20146-20157 NN denotes Correlation
T10523 20133-20136 NN denotes Sex
T10524 20137-20145 JJ denotes Specific
T10525 20136-20137 HYPH denotes -
T10526 20158-20162 IN denotes with
T10527 20163-20170 JJ denotes Gonadal
T10528 20175-20179 NN denotes Mass
T10529 20171-20174 NN denotes Fat
T10530 20179-20543 sentence denotes For each of the 23,574 oligonucleotides represented on the array, we computed a linear regression analysis to test for association between the trait “gonadal fat mass” and each transcript abundance measure, incorporating the terms “gene,” “sex,” and “gene-by-sex,” where the “gene-by-sex” parameter tests for sex-specific correlation between a gene and the trait.
T10531 20180-20183 IN denotes For
T10532 20249-20257 VBD denotes computed
T10533 20184-20188 DT denotes each
T10534 20189-20191 IN denotes of
T10535 20192-20195 DT denotes the
T10536 20203-20219 NNS denotes oligonucleotides
T10537 20196-20202 CD denotes 23,574
T10538 20220-20231 VBN denotes represented
T10539 20232-20234 IN denotes on
T10540 20235-20238 DT denotes the
T10541 20239-20244 NN denotes array
T10542 20244-20246 , denotes ,
T10543 20246-20248 PRP denotes we
T10544 20258-20259 DT denotes a
T10545 20278-20286 NN denotes analysis
T10546 20260-20266 JJ denotes linear
T10547 20267-20277 NN denotes regression
T10548 20287-20289 TO denotes to
T10549 20290-20294 VB denotes test
T10550 20295-20298 IN denotes for
T10551 20299-20310 NN denotes association
T10552 20311-20318 IN denotes between
T10553 20319-20322 DT denotes the
T10554 20323-20328 NN denotes trait
T10555 20329-20330 `` denotes “
T10556 20330-20337 JJ denotes gonadal
T10557 20342-20346 NN denotes mass
T10558 20338-20341 NN denotes fat
T10559 20346-20347 '' denotes ”
T10560 20348-20351 CC denotes and
T10561 20352-20356 DT denotes each
T10562 20378-20385 NN denotes measure
T10563 20357-20367 NN denotes transcript
T10564 20368-20377 NN denotes abundance
T10565 20385-20387 , denotes ,
T10566 20387-20400 VBG denotes incorporating
T10567 20401-20404 DT denotes the
T10568 20405-20410 NNS denotes terms
T10569 20411-20412 `` denotes “
T10570 20412-20416 NN denotes gene
T10571 20416-20417 , denotes ,
T10572 20417-20418 '' denotes ”
T10573 20420-20423 NN denotes sex
T10574 20419-20420 `` denotes “
T10575 20423-20424 , denotes ,
T10576 20424-20425 '' denotes ”
T10577 20426-20429 CC denotes and
T10578 20430-20431 `` denotes “
T10579 20431-20435 NN denotes gene
T10580 20435-20436 HYPH denotes -
T10581 20436-20438 IN denotes by
T10582 20438-20439 HYPH denotes -
T10583 20439-20442 NN denotes sex
T10584 20442-20443 , denotes ,
T10585 20443-20444 '' denotes ”
T10586 20445-20450 WRB denotes where
T10587 20479-20484 VBZ denotes tests
T10588 20451-20454 DT denotes the
T10589 20469-20478 NN denotes parameter
T10590 20455-20456 `` denotes “
T10591 20456-20460 NN denotes gene
T10592 20460-20461 HYPH denotes -
T10593 20461-20463 IN denotes by
T10594 20463-20464 HYPH denotes -
T10595 20464-20467 NN denotes sex
T10596 20467-20468 '' denotes ”
T10597 20485-20488 IN denotes for
T10598 20489-20492 NN denotes sex
T10599 20493-20501 JJ denotes specific
T10600 20492-20493 HYPH denotes -
T10601 20502-20513 NN denotes correlation
T10602 20514-20521 IN denotes between
T10603 20522-20523 DT denotes a
T10604 20524-20528 NN denotes gene
T10605 20529-20532 CC denotes and
T10606 20533-20536 DT denotes the
T10607 20537-20542 NN denotes trait
T10608 20542-20543 . denotes .
T10609 20543-20714 sentence denotes As before, a stepwise regression procedure was used to determine if the addition of the interaction term significantly improved the model fit (see Materials and Methods).
T10610 20544-20546 IN denotes As
T10611 20591-20595 VBN denotes used
T10612 20547-20553 RB denotes before
T10613 20553-20555 , denotes ,
T10614 20555-20556 DT denotes a
T10615 20577-20586 NN denotes procedure
T10616 20557-20565 NN denotes stepwise
T10617 20566-20576 NN denotes regression
T10618 20587-20590 VBD denotes was
T10619 20596-20598 TO denotes to
T10620 20599-20608 VB denotes determine
T10621 20609-20611 IN denotes if
T10622 20663-20671 VBD denotes improved
T10623 20612-20615 DT denotes the
T10624 20616-20624 NN denotes addition
T10625 20625-20627 IN denotes of
T10626 20628-20631 DT denotes the
T10627 20644-20648 NN denotes term
T10628 20632-20643 NN denotes interaction
T10629 20649-20662 RB denotes significantly
T10630 20672-20675 DT denotes the
T10631 20682-20685 NN denotes fit
T10632 20676-20681 NN denotes model
T10633 20686-20687 -LRB- denotes (
T10634 20687-20690 VB denotes see
T10635 20691-20700 NNS denotes Materials
T10636 20701-20704 CC denotes and
T10637 20705-20712 NNS denotes Methods
T10638 20712-20713 -RRB- denotes )
T10639 20713-20714 . denotes .
T10640 20714-20773 sentence denotes Multiple testing was addressed by controlling for the FDR.
T10641 20715-20723 JJ denotes Multiple
T10642 20724-20731 NN denotes testing
T10643 20736-20745 VBN denotes addressed
T10644 20732-20735 VBD denotes was
T10645 20746-20748 IN denotes by
T10646 20749-20760 VBG denotes controlling
T10647 20761-20764 IN denotes for
T10648 20765-20768 DT denotes the
T10649 20769-20772 NN denotes FDR
T10650 20772-20773 . denotes .
T10651 20773-20865 sentence denotes Distribution of the p-values obtained from these 23,574 correlations is shown in Figure 5A.
T10652 20774-20786 NN denotes Distribution
T10653 20846-20851 VBN denotes shown
T10654 20787-20789 IN denotes of
T10655 20790-20793 DT denotes the
T10656 20796-20802 NNS denotes values
T10657 20794-20795 NN denotes p
T10658 20795-20796 HYPH denotes -
T10659 20803-20811 VBN denotes obtained
T10660 20812-20816 IN denotes from
T10661 20817-20822 DT denotes these
T10662 20830-20842 NNS denotes correlations
T10663 20823-20829 CD denotes 23,574
T10664 20843-20845 VBZ denotes is
T10665 20852-20854 IN denotes in
T10666 20855-20861 NN denotes Figure
T10667 20862-20864 NN denotes 5A
T10668 20864-20865 . denotes .
T10669 20865-20945 sentence denotes At FDR = 0.01, 4,613 genes were significantly correlated with gonadal fat mass.
T10670 20866-20868 IN denotes At
T10671 20912-20922 VBN denotes correlated
T10672 20869-20872 NN denotes FDR
T10673 20875-20879 CD denotes 0.01
T10674 20873-20874 SYM denotes =
T10675 20879-20881 , denotes ,
T10676 20881-20886 CD denotes 4,613
T10677 20887-20892 NNS denotes genes
T10678 20893-20897 VBD denotes were
T10679 20898-20911 RB denotes significantly
T10680 20923-20927 IN denotes with
T10681 20928-20935 JJ denotes gonadal
T10682 20940-20944 NN denotes mass
T10683 20936-20939 NN denotes fat
T10684 20944-20945 . denotes .
T10685 20945-21102 sentence denotes Of these genes, 4,524 (98%) showed significant “gene-by-sex” effects, supporting the high degree of sex specificity in the genetic regulation of this trait.
T10686 20946-20948 IN denotes Of
T10687 20974-20980 VBD denotes showed
T10688 20949-20954 DT denotes these
T10689 20955-20960 NNS denotes genes
T10690 20960-20962 , denotes ,
T10691 20962-20967 CD denotes 4,524
T10692 20968-20969 -LRB- denotes (
T10693 20971-20972 NN denotes %
T10694 20969-20971 CD denotes 98
T10695 20972-20973 -RRB- denotes )
T10696 20981-20992 JJ denotes significant
T10697 21007-21014 NNS denotes effects
T10698 20993-20994 `` denotes “
T10699 20994-20998 NN denotes gene
T10700 20998-20999 HYPH denotes -
T10701 20999-21001 IN denotes by
T10702 21001-21002 HYPH denotes -
T10703 21002-21005 NN denotes sex
T10704 21005-21006 '' denotes ”
T10705 21014-21016 , denotes ,
T10706 21016-21026 VBG denotes supporting
T10707 21027-21030 DT denotes the
T10708 21036-21042 NN denotes degree
T10709 21031-21035 JJ denotes high
T10710 21043-21045 IN denotes of
T10711 21046-21049 NN denotes sex
T10712 21050-21061 NN denotes specificity
T10713 21062-21064 IN denotes in
T10714 21065-21068 DT denotes the
T10715 21077-21087 NN denotes regulation
T10716 21069-21076 JJ denotes genetic
T10717 21088-21090 IN denotes of
T10718 21091-21095 DT denotes this
T10719 21096-21101 NN denotes trait
T10720 21101-21102 . denotes .
T10721 21102-21189 sentence denotes A complete list of all genes correlated with gonadal fat mass is provided in Table S2.
T10722 21103-21104 DT denotes A
T10723 21114-21118 NN denotes list
T10724 21105-21113 JJ denotes complete
T10725 21168-21176 VBN denotes provided
T10726 21119-21121 IN denotes of
T10727 21122-21125 DT denotes all
T10728 21126-21131 NNS denotes genes
T10729 21132-21142 VBN denotes correlated
T10730 21143-21147 IN denotes with
T10731 21148-21155 JJ denotes gonadal
T10732 21160-21164 NN denotes mass
T10733 21156-21159 NN denotes fat
T10734 21165-21167 VBZ denotes is
T10735 21177-21179 IN denotes in
T10736 21180-21185 NN denotes Table
T10737 21186-21188 NN denotes S2
T10738 21188-21189 . denotes .
T10739 21189-22333 sentence denotes Figure 5 Properties of Transcripts Significantly Correlated with Gonadal Fat Mass (A) Distribution of p-values for trait–gene correlations between transcripts and gonadal fat mass. At FDR = 0.01, 4,613 transcripts are significantly correlated with the trait. (B) Number of eQTLs generated by the 4,613 genes significantly correlated with gonadal fat mass. Of these, 1,130 genes possessed at least one significant eQTL. (C) Distribution of 1,478 eQTLs significantly correlated with gonadal fat mass across the genome in 2-cM bins. (D) Identification of genomic regions enriched for eQTLs correlated with gonadal fat mass. The x-axis represents genome position in 2-cM bins, and the y-axis represents the −log10 Fisher exact test p-value for enrichment of eQTLs in overlapping 6-cM bins. The dashed line corresponds to p = 0.05 after correction for multiple comparisons. One significantly enriched region on Chromosome 19 is shown. The Chromosome 19 (40-cM) hotspot is coincident with a cQTL for gonadal fat mass and is highlighted in red. Of the 4,613 genes correlated with gonadal fat mass, 1,130 generate 1,478 significant eQTLs (Figure 5B).
T10740 22229-22231 IN denotes Of
T10741 22288-22296 VBP denotes generate
T10742 22232-22235 DT denotes the
T10743 22242-22247 NNS denotes genes
T10744 22236-22241 CD denotes 4,613
T10745 22248-22258 VBN denotes correlated
T10746 22259-22263 IN denotes with
T10747 22264-22271 JJ denotes gonadal
T10748 22276-22280 NN denotes mass
T10749 22272-22275 NN denotes fat
T10750 22280-22282 , denotes ,
T10751 22282-22287 CD denotes 1,130
T10752 22297-22302 CD denotes 1,478
T10753 22315-22320 NNS denotes eQTLs
T10754 22303-22314 JJ denotes significant
T10755 22321-22322 -LRB- denotes (
T10756 22329-22331 NN denotes 5B
T10757 22322-22328 NN denotes Figure
T10758 22331-22332 -RRB- denotes )
T10759 22332-22333 . denotes .
T10760 22333-22492 sentence denotes The colocalization of eQTLs for these correlated genes with the cQTL for the fat mass trait provides useful implications for the possible role of these genes.
T10761 22334-22337 DT denotes The
T10762 22338-22352 NN denotes colocalization
T10763 22426-22434 VBZ denotes provides
T10764 22353-22355 IN denotes of
T10765 22356-22361 NNS denotes eQTLs
T10766 22362-22365 IN denotes for
T10767 22366-22371 DT denotes these
T10768 22383-22388 NNS denotes genes
T10769 22372-22382 VBN denotes correlated
T10770 22389-22393 IN denotes with
T10771 22394-22397 DT denotes the
T10772 22398-22402 NN denotes cQTL
T10773 22403-22406 IN denotes for
T10774 22407-22410 DT denotes the
T10775 22420-22425 NN denotes trait
T10776 22411-22414 NN denotes fat
T10777 22415-22419 NN denotes mass
T10778 22435-22441 JJ denotes useful
T10779 22442-22454 NNS denotes implications
T10780 22455-22458 IN denotes for
T10781 22459-22462 DT denotes the
T10782 22472-22476 NN denotes role
T10783 22463-22471 JJ denotes possible
T10784 22477-22479 IN denotes of
T10785 22480-22485 DT denotes these
T10786 22486-22491 NNS denotes genes
T10787 22491-22492 . denotes .
T10788 22492-22561 sentence denotes Whether the eQTLs are cis or trans determines what that role may be.
T10789 22493-22500 IN denotes Whether
T10790 22511-22514 VBP denotes are
T10791 22501-22504 DT denotes the
T10792 22505-22510 NNS denotes eQTLs
T10793 22528-22538 VBZ denotes determines
T10794 22515-22518 NN denotes cis
T10795 22519-22521 CC denotes or
T10796 22522-22527 NN denotes trans
T10797 22539-22543 WP denotes what
T10798 22558-22560 VB denotes be
T10799 22544-22548 DT denotes that
T10800 22549-22553 NN denotes role
T10801 22554-22557 MD denotes may
T10802 22560-22561 . denotes .
T10803 22561-22831 sentence denotes Genes that show significant correlation with the gonadal fat mass trait and that have cis-eQTLs coincident with the fat mass cQTLs are potential candidate genes for the trait (i.e., they may contain a genetic variation in that gene that is the cause of the trait cQTL).
T10804 22562-22567 NNS denotes Genes
T10805 22693-22696 VBP denotes are
T10806 22568-22572 WDT denotes that
T10807 22573-22577 VBP denotes show
T10808 22578-22589 JJ denotes significant
T10809 22590-22601 NN denotes correlation
T10810 22602-22606 IN denotes with
T10811 22607-22610 DT denotes the
T10812 22628-22633 NN denotes trait
T10813 22611-22618 JJ denotes gonadal
T10814 22623-22627 NN denotes mass
T10815 22619-22622 NN denotes fat
T10816 22634-22637 CC denotes and
T10817 22638-22642 WDT denotes that
T10818 22643-22647 VBP denotes have
T10819 22648-22651 NN denotes cis
T10820 22652-22657 NNS denotes eQTLs
T10821 22651-22652 HYPH denotes -
T10822 22658-22668 JJ denotes coincident
T10823 22669-22673 IN denotes with
T10824 22674-22677 DT denotes the
T10825 22687-22692 NNS denotes cQTLs
T10826 22678-22681 NN denotes fat
T10827 22682-22686 NN denotes mass
T10828 22697-22706 JJ denotes potential
T10829 22717-22722 NNS denotes genes
T10830 22707-22716 NN denotes candidate
T10831 22723-22726 IN denotes for
T10832 22727-22730 DT denotes the
T10833 22731-22736 NN denotes trait
T10834 22737-22738 -LRB- denotes (
T10835 22753-22760 VB denotes contain
T10836 22738-22742 FW denotes i.e.
T10837 22742-22744 , denotes ,
T10838 22744-22748 PRP denotes they
T10839 22749-22752 MD denotes may
T10840 22761-22762 DT denotes a
T10841 22771-22780 NN denotes variation
T10842 22763-22770 JJ denotes genetic
T10843 22781-22783 IN denotes in
T10844 22784-22788 DT denotes that
T10845 22789-22793 NN denotes gene
T10846 22794-22798 WDT denotes that
T10847 22799-22801 VBZ denotes is
T10848 22802-22805 DT denotes the
T10849 22806-22811 NN denotes cause
T10850 22812-22814 IN denotes of
T10851 22815-22818 DT denotes the
T10852 22825-22829 NN denotes cQTL
T10853 22819-22824 NN denotes trait
T10854 22829-22830 -RRB- denotes )
T10855 22830-22831 . denotes .
T10856 22831-22966 sentence denotes Table 5 summarizes the genes that possess these properties for each cQTL, increasing evidence for these genes as potential candidates.
T10857 22832-22837 NN denotes Table
T10858 22840-22850 VBZ denotes summarizes
T10859 22838-22839 CD denotes 5
T10860 22851-22854 DT denotes the
T10861 22855-22860 NNS denotes genes
T10862 22861-22865 WDT denotes that
T10863 22866-22873 VBP denotes possess
T10864 22874-22879 DT denotes these
T10865 22880-22890 NNS denotes properties
T10866 22891-22894 IN denotes for
T10867 22895-22899 DT denotes each
T10868 22900-22904 NN denotes cQTL
T10869 22904-22906 , denotes ,
T10870 22906-22916 VBG denotes increasing
T10871 22917-22925 NN denotes evidence
T10872 22926-22929 IN denotes for
T10873 22930-22935 DT denotes these
T10874 22936-22941 NNS denotes genes
T10875 22942-22944 IN denotes as
T10876 22945-22954 JJ denotes potential
T10877 22955-22965 NNS denotes candidates
T10878 22965-22966 . denotes .
T10879 22966-23132 sentence denotes As addressed below, given the complex multiorgan regulation of adipose tissue mass, it is unlikely that the genetic regulation of all five loci resides in the liver.
T10880 22967-22969 IN denotes As
T10881 22970-22979 VBN denotes addressed
T10882 23054-23056 VBZ denotes is
T10883 22980-22985 RB denotes below
T10884 22985-22987 , denotes ,
T10885 22987-22992 VBN denotes given
T10886 22993-22996 DT denotes the
T10887 23016-23026 NN denotes regulation
T10888 22997-23004 JJ denotes complex
T10889 23005-23015 NN denotes multiorgan
T10890 23027-23029 IN denotes of
T10891 23030-23037 NN denotes adipose
T10892 23038-23044 NN denotes tissue
T10893 23045-23049 NN denotes mass
T10894 23049-23051 , denotes ,
T10895 23051-23053 PRP denotes it
T10896 23057-23065 JJ denotes unlikely
T10897 23066-23070 IN denotes that
T10898 23111-23118 VBZ denotes resides
T10899 23071-23074 DT denotes the
T10900 23083-23093 NN denotes regulation
T10901 23075-23082 JJ denotes genetic
T10902 23094-23096 IN denotes of
T10903 23097-23100 DT denotes all
T10904 23106-23110 NNS denotes loci
T10905 23101-23105 CD denotes five
T10906 23119-23121 IN denotes in
T10907 23122-23125 DT denotes the
T10908 23126-23131 NN denotes liver
T10909 23131-23132 . denotes .
T10910 23132-23278 sentence denotes However, some may involve the liver, and even for those that do not, the liver transcriptional variation may reflect that of the relevant tissue.
T10911 23133-23140 RB denotes However
T10912 23151-23158 VB denotes involve
T10913 23140-23142 , denotes ,
T10914 23142-23146 DT denotes some
T10915 23147-23150 MD denotes may
T10916 23159-23162 DT denotes the
T10917 23163-23168 NN denotes liver
T10918 23168-23170 , denotes ,
T10919 23170-23173 CC denotes and
T10920 23174-23178 RB denotes even
T10921 23179-23182 IN denotes for
T10922 23242-23249 VB denotes reflect
T10923 23183-23188 DT denotes those
T10924 23189-23193 WDT denotes that
T10925 23197-23200 RB denotes not
T10926 23194-23196 VBP denotes do
T10927 23200-23202 , denotes ,
T10928 23202-23205 DT denotes the
T10929 23228-23237 NN denotes variation
T10930 23206-23211 NN denotes liver
T10931 23212-23227 JJ denotes transcriptional
T10932 23238-23241 MD denotes may
T10933 23250-23254 DT denotes that
T10934 23255-23257 IN denotes of
T10935 23258-23261 DT denotes the
T10936 23271-23277 NN denotes tissue
T10937 23262-23270 JJ denotes relevant
T10938 23277-23278 . denotes .
T10939 23278-23508 sentence denotes Genes that show significant correlation with gonadal fat mass and have trans-eQTLs coincident with the fat mass cQTL cannot be candidates directly responsible for the trait, as they are physically located elsewhere in the genome.
T10940 23279-23284 NNS denotes Genes
T10941 23403-23405 VB denotes be
T10942 23285-23289 WDT denotes that
T10943 23290-23294 VBP denotes show
T10944 23295-23306 JJ denotes significant
T10945 23307-23318 NN denotes correlation
T10946 23319-23323 IN denotes with
T10947 23324-23331 JJ denotes gonadal
T10948 23336-23340 NN denotes mass
T10949 23332-23335 NN denotes fat
T10950 23341-23344 CC denotes and
T10951 23345-23349 VBP denotes have
T10952 23350-23355 NN denotes trans
T10953 23356-23361 NNS denotes eQTLs
T10954 23355-23356 HYPH denotes -
T10955 23362-23372 JJ denotes coincident
T10956 23373-23377 IN denotes with
T10957 23378-23381 DT denotes the
T10958 23391-23395 NN denotes cQTL
T10959 23382-23385 NN denotes fat
T10960 23386-23390 NN denotes mass
T10961 23396-23399 MD denotes can
T10962 23399-23402 RB denotes not
T10963 23406-23416 NNS denotes candidates
T10964 23417-23425 RB denotes directly
T10965 23426-23437 JJ denotes responsible
T10966 23438-23441 IN denotes for
T10967 23442-23445 DT denotes the
T10968 23446-23451 NN denotes trait
T10969 23451-23453 , denotes ,
T10970 23453-23455 IN denotes as
T10971 23476-23483 VBN denotes located
T10972 23456-23460 PRP denotes they
T10973 23461-23464 VBP denotes are
T10974 23465-23475 RB denotes physically
T10975 23484-23493 RB denotes elsewhere
T10976 23494-23496 IN denotes in
T10977 23497-23500 DT denotes the
T10978 23501-23507 NN denotes genome
T10979 23507-23508 . denotes .
T10980 23508-23722 sentence denotes However, they are potentially involved in the pathway(s) leading from the causative gene to the expression of the fat mass trait (i.e., their transcription is closely regulated by the causative gene at the locus).
T10981 23509-23516 RB denotes However
T10982 23539-23547 VBN denotes involved
T10983 23516-23518 , denotes ,
T10984 23518-23522 PRP denotes they
T10985 23523-23526 VBP denotes are
T10986 23527-23538 RB denotes potentially
T10987 23548-23550 IN denotes in
T10988 23551-23554 DT denotes the
T10989 23555-23562 NN denotes pathway
T10990 23562-23563 -LRB- denotes (
T10991 23563-23564 AFX denotes s
T10992 23564-23565 -RRB- denotes )
T10993 23566-23573 VBG denotes leading
T10994 23574-23578 IN denotes from
T10995 23579-23582 DT denotes the
T10996 23593-23597 NN denotes gene
T10997 23583-23592 JJ denotes causative
T10998 23598-23600 IN denotes to
T10999 23601-23604 DT denotes the
T11000 23605-23615 NN denotes expression
T11001 23616-23618 IN denotes of
T11002 23619-23622 DT denotes the
T11003 23632-23637 NN denotes trait
T11004 23623-23626 NN denotes fat
T11005 23627-23631 NN denotes mass
T11006 23638-23639 -LRB- denotes (
T11007 23676-23685 VBN denotes regulated
T11008 23639-23643 FW denotes i.e.
T11009 23643-23645 , denotes ,
T11010 23645-23650 PRP$ denotes their
T11011 23651-23664 NN denotes transcription
T11012 23665-23667 VBZ denotes is
T11013 23668-23675 RB denotes closely
T11014 23686-23688 IN denotes by
T11015 23689-23692 DT denotes the
T11016 23703-23707 NN denotes gene
T11017 23693-23702 JJ denotes causative
T11018 23708-23710 IN denotes at
T11019 23711-23714 DT denotes the
T11020 23715-23720 NN denotes locus
T11021 23720-23721 -RRB- denotes )
T11022 23721-23722 . denotes .
T11023 23722-23805 sentence denotes All of the five fat mass cQTLs have colocalizing trans-eQTLs for correlated genes.
T11024 23723-23726 DT denotes All
T11025 23754-23758 VBP denotes have
T11026 23727-23729 IN denotes of
T11027 23730-23733 DT denotes the
T11028 23748-23753 NNS denotes cQTLs
T11029 23734-23738 CD denotes five
T11030 23739-23742 NN denotes fat
T11031 23743-23747 NN denotes mass
T11032 23759-23771 VBG denotes colocalizing
T11033 23778-23783 NNS denotes eQTLs
T11034 23772-23777 NN denotes trans
T11035 23777-23778 HYPH denotes -
T11036 23784-23787 IN denotes for
T11037 23788-23798 VBN denotes correlated
T11038 23799-23804 NNS denotes genes
T11039 23804-23805 . denotes .
T11040 23805-23984 sentence denotes However, for a trait such as fat mass that is regulated by multiple tissues and organs, it is unlikely that all five fat mass cQTLs are primarily driven by liver gene expression.
T11041 23806-23813 RB denotes However
T11042 23897-23899 VBZ denotes is
T11043 23813-23815 , denotes ,
T11044 23815-23818 IN denotes for
T11045 23819-23820 DT denotes a
T11046 23821-23826 NN denotes trait
T11047 23827-23831 JJ denotes such
T11048 23832-23834 IN denotes as
T11049 23835-23838 NN denotes fat
T11050 23839-23843 NN denotes mass
T11051 23844-23848 WDT denotes that
T11052 23852-23861 VBN denotes regulated
T11053 23849-23851 VBZ denotes is
T11054 23862-23864 IN denotes by
T11055 23865-23873 JJ denotes multiple
T11056 23874-23881 NNS denotes tissues
T11057 23882-23885 CC denotes and
T11058 23886-23892 NNS denotes organs
T11059 23892-23894 , denotes ,
T11060 23894-23896 PRP denotes it
T11061 23900-23908 JJ denotes unlikely
T11062 23909-23913 IN denotes that
T11063 23952-23958 VBN denotes driven
T11064 23914-23917 DT denotes all
T11065 23932-23937 NNS denotes cQTLs
T11066 23918-23922 CD denotes five
T11067 23923-23926 NN denotes fat
T11068 23927-23931 NN denotes mass
T11069 23938-23941 VBP denotes are
T11070 23942-23951 RB denotes primarily
T11071 23959-23961 IN denotes by
T11072 23962-23967 NN denotes liver
T11073 23973-23983 NN denotes expression
T11074 23968-23972 NN denotes gene
T11075 23983-23984 . denotes .
T11076 23984-24274 sentence denotes As an approach to this problem, we hypothesized that those cQTLs that are most closely associated with liver gene expression would show an overrepresentation of colocalized eQTL for correlated genes, while those loci primarily controlled by other tissues would not have shown this pattern.
T11077 23985-23987 IN denotes As
T11078 24020-24032 VBD denotes hypothesized
T11079 23988-23990 DT denotes an
T11080 23991-23999 NN denotes approach
T11081 24000-24002 IN denotes to
T11082 24003-24007 DT denotes this
T11083 24008-24015 NN denotes problem
T11084 24015-24017 , denotes ,
T11085 24017-24019 PRP denotes we
T11086 24033-24037 IN denotes that
T11087 24116-24120 VB denotes show
T11088 24038-24043 DT denotes those
T11089 24044-24049 NNS denotes cQTLs
T11090 24050-24054 WDT denotes that
T11091 24072-24082 VBN denotes associated
T11092 24055-24058 VBP denotes are
T11093 24059-24063 RBS denotes most
T11094 24064-24071 RB denotes closely
T11095 24083-24087 IN denotes with
T11096 24088-24093 NN denotes liver
T11097 24099-24109 NN denotes expression
T11098 24094-24098 NN denotes gene
T11099 24110-24115 MD denotes would
T11100 24121-24123 DT denotes an
T11101 24124-24142 NN denotes overrepresentation
T11102 24143-24145 IN denotes of
T11103 24146-24157 VBN denotes colocalized
T11104 24158-24162 NN denotes eQTL
T11105 24163-24166 IN denotes for
T11106 24167-24177 VBN denotes correlated
T11107 24178-24183 NNS denotes genes
T11108 24183-24185 , denotes ,
T11109 24185-24190 IN denotes while
T11110 24255-24260 VBN denotes shown
T11111 24191-24196 DT denotes those
T11112 24197-24201 NNS denotes loci
T11113 24202-24211 RB denotes primarily
T11114 24212-24222 VBN denotes controlled
T11115 24223-24225 IN denotes by
T11116 24226-24231 JJ denotes other
T11117 24232-24239 NNS denotes tissues
T11118 24240-24245 MD denotes would
T11119 24246-24249 RB denotes not
T11120 24250-24254 VB denotes have
T11121 24261-24265 DT denotes this
T11122 24266-24273 NN denotes pattern
T11123 24273-24274 . denotes .
T11124 24274-24402 sentence denotes To assess this, we first determined the distribution of these 1,478 eQTLs across the genome in 2-cM bins as shown in Figure 5C.
T11125 24275-24277 TO denotes To
T11126 24278-24284 VB denotes assess
T11127 24300-24310 VBD denotes determined
T11128 24285-24289 DT denotes this
T11129 24289-24291 , denotes ,
T11130 24291-24293 PRP denotes we
T11131 24294-24299 RB denotes first
T11132 24311-24314 DT denotes the
T11133 24315-24327 NN denotes distribution
T11134 24328-24330 IN denotes of
T11135 24331-24336 DT denotes these
T11136 24343-24348 NNS denotes eQTLs
T11137 24337-24342 CD denotes 1,478
T11138 24349-24355 IN denotes across
T11139 24356-24359 DT denotes the
T11140 24360-24366 NN denotes genome
T11141 24367-24369 IN denotes in
T11142 24370-24371 CD denotes 2
T11143 24372-24374 NN denotes cM
T11144 24371-24372 HYPH denotes -
T11145 24375-24379 NNS denotes bins
T11146 24380-24382 IN denotes as
T11147 24383-24388 VBN denotes shown
T11148 24389-24391 IN denotes in
T11149 24392-24398 NN denotes Figure
T11150 24399-24401 NN denotes 5C
T11151 24401-24402 . denotes .
T11152 24402-24634 sentence denotes In order to see if there exist any hotspots for these eQTLs, we tested eQTLs with p < 0.001 for enrichment along the genome in overlapping 2-cM bins against the distribution of all liver eQTLs (Figure 4A) using a Fisher exact test.
T11153 24403-24405 IN denotes In
T11154 24467-24473 VBD denotes tested
T11155 24406-24411 NN denotes order
T11156 24412-24414 TO denotes to
T11157 24415-24418 VB denotes see
T11158 24419-24421 IN denotes if
T11159 24428-24433 VBP denotes exist
T11160 24422-24427 EX denotes there
T11161 24434-24437 DT denotes any
T11162 24438-24446 NNS denotes hotspots
T11163 24447-24450 IN denotes for
T11164 24451-24456 DT denotes these
T11165 24457-24462 NNS denotes eQTLs
T11166 24462-24464 , denotes ,
T11167 24464-24466 PRP denotes we
T11168 24474-24479 NNS denotes eQTLs
T11169 24480-24484 IN denotes with
T11170 24485-24486 NN denotes p
T11171 24487-24488 SYM denotes <
T11172 24489-24494 CD denotes 0.001
T11173 24495-24498 IN denotes for
T11174 24499-24509 NN denotes enrichment
T11175 24510-24515 IN denotes along
T11176 24516-24519 DT denotes the
T11177 24520-24526 NN denotes genome
T11178 24527-24529 IN denotes in
T11179 24530-24541 VBG denotes overlapping
T11180 24547-24551 NNS denotes bins
T11181 24542-24543 CD denotes 2
T11182 24544-24546 NN denotes cM
T11183 24543-24544 HYPH denotes -
T11184 24552-24559 IN denotes against
T11185 24560-24563 DT denotes the
T11186 24564-24576 NN denotes distribution
T11187 24577-24579 IN denotes of
T11188 24580-24583 DT denotes all
T11189 24590-24595 NNS denotes eQTLs
T11190 24584-24589 NN denotes liver
T11191 24596-24597 -LRB- denotes (
T11192 24604-24606 NN denotes 4A
T11193 24597-24603 NN denotes Figure
T11194 24606-24607 -RRB- denotes )
T11195 24608-24613 VBG denotes using
T11196 24614-24615 DT denotes a
T11197 24629-24633 NN denotes test
T11198 24616-24622 NNP denotes Fisher
T11199 24623-24628 JJ denotes exact
T11200 24633-24634 . denotes .
T11201 24634-24745 sentence denotes Figure 5D shows the significance of enrichment reported as −log10 of the enrichment p-value across the genome.
T11202 24635-24641 NN denotes Figure
T11203 24642-24644 NN denotes 5D
T11204 24645-24650 VBZ denotes shows
T11205 24651-24654 DT denotes the
T11206 24655-24667 NN denotes significance
T11207 24668-24670 IN denotes of
T11208 24671-24681 NN denotes enrichment
T11209 24682-24690 VBN denotes reported
T11210 24691-24693 IN denotes as
T11211 24694-24695 HYPH denotes −
T11212 24695-24700 NN denotes log10
T11213 24701-24703 IN denotes of
T11214 24704-24707 DT denotes the
T11215 24721-24726 NN denotes value
T11216 24708-24718 NN denotes enrichment
T11217 24719-24720 NN denotes p
T11218 24720-24721 HYPH denotes -
T11219 24727-24733 IN denotes across
T11220 24734-24737 DT denotes the
T11221 24738-24744 NN denotes genome
T11222 24744-24745 . denotes .
T11223 24745-24868 sentence denotes One locus on Chromosome 19 was significantly enriched for eQTLs of transcripts correlated with the gonadal fat mass trait.
T11224 24746-24749 CD denotes One
T11225 24750-24755 NN denotes locus
T11226 24791-24799 VBN denotes enriched
T11227 24756-24758 IN denotes on
T11228 24759-24769 NN denotes Chromosome
T11229 24770-24772 CD denotes 19
T11230 24773-24776 VBD denotes was
T11231 24777-24790 RB denotes significantly
T11232 24800-24803 IN denotes for
T11233 24804-24809 NNS denotes eQTLs
T11234 24810-24812 IN denotes of
T11235 24813-24824 NNS denotes transcripts
T11236 24825-24835 VBN denotes correlated
T11237 24836-24840 IN denotes with
T11238 24841-24844 DT denotes the
T11239 24862-24867 NN denotes trait
T11240 24845-24852 JJ denotes gonadal
T11241 24857-24861 NN denotes mass
T11242 24853-24856 NN denotes fat
T11243 24867-24868 . denotes .
T11244 24868-24992 sentence denotes As anticipated, there was an overlap of a correlated eQTL hotspot and a fat mass cQTL, specifically Chromosome 19 at 40 cM.
T11245 24869-24871 IN denotes As
T11246 24872-24883 VBN denotes anticipated
T11247 24891-24894 VBD denotes was
T11248 24883-24885 , denotes ,
T11249 24885-24890 EX denotes there
T11250 24895-24897 DT denotes an
T11251 24898-24905 NN denotes overlap
T11252 24906-24908 IN denotes of
T11253 24909-24910 DT denotes a
T11254 24927-24934 NN denotes hotspot
T11255 24911-24921 VBN denotes correlated
T11256 24922-24926 NN denotes eQTL
T11257 24935-24938 CC denotes and
T11258 24939-24940 DT denotes a
T11259 24950-24954 NN denotes cQTL
T11260 24941-24944 NN denotes fat
T11261 24945-24949 NN denotes mass
T11262 24954-24956 , denotes ,
T11263 24956-24968 RB denotes specifically
T11264 24969-24979 NN denotes Chromosome
T11265 24980-24982 CD denotes 19
T11266 24983-24985 IN denotes at
T11267 24986-24988 CD denotes 40
T11268 24989-24991 NN denotes cM
T11269 24991-24992 . denotes .
T11270 24992-25160 sentence denotes This suggests that the genetic regulation of fat mass for the Chromosome 19 locus is more closely tied to liver gene expression than are the other four fat mass cQTLs.
T11271 24993-24997 DT denotes This
T11272 24998-25006 VBZ denotes suggests
T11273 25007-25011 IN denotes that
T11274 25091-25095 VBN denotes tied
T11275 25012-25015 DT denotes the
T11276 25024-25034 NN denotes regulation
T11277 25016-25023 JJ denotes genetic
T11278 25035-25037 IN denotes of
T11279 25038-25041 NN denotes fat
T11280 25042-25046 NN denotes mass
T11281 25047-25050 IN denotes for
T11282 25051-25054 DT denotes the
T11283 25069-25074 NN denotes locus
T11284 25055-25065 NN denotes Chromosome
T11285 25066-25068 CD denotes 19
T11286 25075-25077 VBZ denotes is
T11287 25078-25082 RBR denotes more
T11288 25083-25090 RB denotes closely
T11289 25096-25098 IN denotes to
T11290 25099-25104 NN denotes liver
T11291 25110-25120 NN denotes expression
T11292 25105-25109 NN denotes gene
T11293 25121-25125 IN denotes than
T11294 25126-25129 VBP denotes are
T11295 25130-25133 DT denotes the
T11296 25154-25159 NNS denotes cQTLs
T11297 25134-25139 JJ denotes other
T11298 25140-25144 CD denotes four
T11299 25145-25148 NN denotes fat
T11300 25149-25153 NN denotes mass
T11301 25159-25160 . denotes .
T11302 25160-25263 sentence denotes The effect of the trans-eQTLs at the Chromosome 19 locus on gene expression is summarized in Figure 6.
T11303 25161-25164 DT denotes The
T11304 25165-25171 NN denotes effect
T11305 25240-25250 VBN denotes summarized
T11306 25172-25174 IN denotes of
T11307 25175-25178 DT denotes the
T11308 25185-25190 NNS denotes eQTLs
T11309 25179-25184 NN denotes trans
T11310 25184-25185 HYPH denotes -
T11311 25191-25193 IN denotes at
T11312 25194-25197 DT denotes the
T11313 25212-25217 NN denotes locus
T11314 25198-25208 NN denotes Chromosome
T11315 25209-25211 CD denotes 19
T11316 25218-25220 IN denotes on
T11317 25221-25225 NN denotes gene
T11318 25226-25236 NN denotes expression
T11319 25237-25239 VBZ denotes is
T11320 25251-25253 IN denotes in
T11321 25254-25260 NN denotes Figure
T11322 25261-25262 CD denotes 6
T11323 25262-25263 . denotes .
T11324 25263-25441 sentence denotes Twenty-nine trans-eQTLs colocalize to Chromosome 9 at 40 cM, suggesting that 29 genes correlated with gonadal fat mass are regulated in trans by a polymorphism at this position.
T11325 25264-25270 CD denotes Twenty
T11326 25271-25275 CD denotes nine
T11327 25270-25271 HYPH denotes -
T11328 25282-25287 NNS denotes eQTLs
T11329 25276-25281 NN denotes trans
T11330 25281-25282 HYPH denotes -
T11331 25288-25298 VBP denotes colocalize
T11332 25299-25301 IN denotes to
T11333 25302-25312 NN denotes Chromosome
T11334 25313-25314 CD denotes 9
T11335 25315-25317 IN denotes at
T11336 25318-25320 CD denotes 40
T11337 25321-25323 NN denotes cM
T11338 25323-25325 , denotes ,
T11339 25325-25335 VBG denotes suggesting
T11340 25336-25340 IN denotes that
T11341 25387-25396 VBN denotes regulated
T11342 25341-25343 CD denotes 29
T11343 25344-25349 NNS denotes genes
T11344 25350-25360 VBN denotes correlated
T11345 25361-25365 IN denotes with
T11346 25366-25373 JJ denotes gonadal
T11347 25378-25382 NN denotes mass
T11348 25374-25377 NN denotes fat
T11349 25383-25386 VBP denotes are
T11350 25397-25399 IN denotes in
T11351 25400-25405 NN denotes trans
T11352 25406-25408 IN denotes by
T11353 25409-25410 DT denotes a
T11354 25411-25423 NN denotes polymorphism
T11355 25424-25426 IN denotes at
T11356 25427-25431 DT denotes this
T11357 25432-25440 NN denotes position
T11358 25440-25441 . denotes .
T11359 25441-25766 sentence denotes The proportion of gene expression levels controlled by this locus (approximated as the coefficients of determination R 2) differs between males and females for the majority of the transcripts (as in Figure 6A), and for Chromosome 19 (Figure 6B), females demonstrated greater genetic regulation of gene expression than males.
T11360 25442-25445 DT denotes The
T11361 25446-25456 NN denotes proportion
T11362 25564-25571 VBZ denotes differs
T11363 25457-25459 IN denotes of
T11364 25460-25464 NN denotes gene
T11365 25465-25475 NN denotes expression
T11366 25476-25482 NNS denotes levels
T11367 25483-25493 VBN denotes controlled
T11368 25494-25496 IN denotes by
T11369 25497-25501 DT denotes this
T11370 25502-25507 NN denotes locus
T11371 25508-25509 -LRB- denotes (
T11372 25509-25521 VBN denotes approximated
T11373 25522-25524 IN denotes as
T11374 25525-25528 DT denotes the
T11375 25529-25541 NNS denotes coefficients
T11376 25542-25544 IN denotes of
T11377 25545-25558 NN denotes determination
T11378 25559-25562 NN denotes R 2
T11379 25562-25563 -RRB- denotes )
T11380 25572-25579 IN denotes between
T11381 25580-25585 NNS denotes males
T11382 25586-25589 CC denotes and
T11383 25590-25597 NNS denotes females
T11384 25598-25601 IN denotes for
T11385 25602-25605 DT denotes the
T11386 25606-25614 NN denotes majority
T11387 25615-25617 IN denotes of
T11388 25618-25621 DT denotes the
T11389 25622-25633 NNS denotes transcripts
T11390 25634-25635 -LRB- denotes (
T11391 25635-25637 IN denotes as
T11392 25638-25640 IN denotes in
T11393 25641-25647 NN denotes Figure
T11394 25648-25650 NN denotes 6A
T11395 25650-25651 -RRB- denotes )
T11396 25651-25653 , denotes ,
T11397 25653-25656 CC denotes and
T11398 25657-25660 IN denotes for
T11399 25696-25708 VBD denotes demonstrated
T11400 25661-25671 NN denotes Chromosome
T11401 25672-25674 CD denotes 19
T11402 25675-25676 -LRB- denotes (
T11403 25683-25685 NN denotes 6B
T11404 25676-25682 NN denotes Figure
T11405 25685-25686 -RRB- denotes )
T11406 25686-25688 , denotes ,
T11407 25688-25695 NNS denotes females
T11408 25709-25716 JJR denotes greater
T11409 25725-25735 NN denotes regulation
T11410 25717-25724 JJ denotes genetic
T11411 25736-25738 IN denotes of
T11412 25739-25743 NN denotes gene
T11413 25744-25754 NN denotes expression
T11414 25755-25759 IN denotes than
T11415 25760-25765 NNS denotes males
T11416 25765-25766 . denotes .
T11417 25766-25908 sentence denotes This substantial female bias is significantly higher than would be expected to arise by chance for the Chromosome 19 locus (p < 0.001 by χ2).
T11418 25767-25771 DT denotes This
T11419 25791-25795 NN denotes bias
T11420 25772-25783 JJ denotes substantial
T11421 25784-25790 JJ denotes female
T11422 25796-25798 VBZ denotes is
T11423 25799-25812 RB denotes significantly
T11424 25813-25819 JJR denotes higher
T11425 25820-25824 IN denotes than
T11426 25834-25842 VBN denotes expected
T11427 25825-25830 MD denotes would
T11428 25831-25833 VB denotes be
T11429 25843-25845 TO denotes to
T11430 25846-25851 VB denotes arise
T11431 25852-25854 IN denotes by
T11432 25855-25861 NN denotes chance
T11433 25862-25865 IN denotes for
T11434 25866-25869 DT denotes the
T11435 25884-25889 NN denotes locus
T11436 25870-25880 NN denotes Chromosome
T11437 25881-25883 CD denotes 19
T11438 25890-25891 -LRB- denotes (
T11439 25895-25900 CD denotes 0.001
T11440 25891-25892 NN denotes p
T11441 25893-25894 SYM denotes <
T11442 25901-25903 IN denotes by
T11443 25904-25906 NN denotes χ2
T11444 25906-25907 -RRB- denotes )
T11445 25907-25908 . denotes .
T11446 25908-26199 sentence denotes This locus corresponds to one of the four sex-biased cQTLs for gonadal fat mass reported in this study, and the significant sex specificity of both the cis and trans genetic regulation of liver genes correlated with fat mass supports the functional significance of this locus in this organ.
T11447 25909-25913 DT denotes This
T11448 25914-25919 NN denotes locus
T11449 25920-25931 VBZ denotes corresponds
T11450 25932-25934 IN denotes to
T11451 25935-25938 CD denotes one
T11452 25939-25941 IN denotes of
T11453 25942-25945 DT denotes the
T11454 25962-25967 NNS denotes cQTLs
T11455 25946-25950 CD denotes four
T11456 25951-25954 NN denotes sex
T11457 25955-25961 VBN denotes biased
T11458 25954-25955 HYPH denotes -
T11459 25968-25971 IN denotes for
T11460 25972-25979 JJ denotes gonadal
T11461 25984-25988 NN denotes mass
T11462 25980-25983 NN denotes fat
T11463 25989-25997 VBN denotes reported
T11464 25998-26000 IN denotes in
T11465 26001-26005 DT denotes this
T11466 26006-26011 NN denotes study
T11467 26011-26013 , denotes ,
T11468 26013-26016 CC denotes and
T11469 26017-26020 DT denotes the
T11470 26037-26048 NN denotes specificity
T11471 26021-26032 JJ denotes significant
T11472 26033-26036 NN denotes sex
T11473 26134-26142 VBZ denotes supports
T11474 26049-26051 IN denotes of
T11475 26052-26056 CC denotes both
T11476 26061-26064 NN denotes cis
T11477 26057-26060 DT denotes the
T11478 26083-26093 NN denotes regulation
T11479 26065-26068 CC denotes and
T11480 26069-26074 NN denotes trans
T11481 26075-26082 JJ denotes genetic
T11482 26094-26096 IN denotes of
T11483 26097-26102 NN denotes liver
T11484 26103-26108 NNS denotes genes
T11485 26109-26119 VBN denotes correlated
T11486 26120-26124 IN denotes with
T11487 26125-26128 NN denotes fat
T11488 26129-26133 NN denotes mass
T11489 26143-26146 DT denotes the
T11490 26158-26170 NN denotes significance
T11491 26147-26157 JJ denotes functional
T11492 26171-26173 IN denotes of
T11493 26174-26178 DT denotes this
T11494 26179-26184 NN denotes locus
T11495 26185-26187 IN denotes in
T11496 26188-26192 DT denotes this
T11497 26193-26198 NN denotes organ
T11498 26198-26199 . denotes .
T11696 27111-27113 IN denotes In
T11697 27129-27138 VBD denotes described
T11698 27114-27118 DT denotes this
T11699 27119-27124 NN denotes study
T11700 27124-27126 , denotes ,
T11701 27126-27128 PRP denotes we
T11702 27139-27140 DT denotes a
T11703 27185-27195 NN denotes population
T11704 27141-27146 JJ denotes large
T11705 27146-27148 , denotes ,
T11706 27148-27155 RB denotes densely
T11707 27156-27162 VBN denotes mapped
T11708 27162-27164 , denotes ,
T11709 27164-27175 VBG denotes segregating
T11710 27176-27178 NN denotes F2
T11711 27179-27184 NN denotes mouse
T11712 27196-27204 VBN denotes designed
T11713 27205-27207 TO denotes to
T11714 27208-27213 VB denotes study
T11715 27214-27217 DT denotes the
T11716 27226-27236 NN denotes regulation
T11717 27218-27225 JJ denotes genetic
T11718 27237-27239 IN denotes of
T11719 27240-27247 JJ denotes several
T11720 27248-27254 NNS denotes traits
T11721 27255-27265 VBN denotes associated
T11722 27266-27270 IN denotes with
T11723 27271-27274 DT denotes the
T11724 27295-27303 NN denotes syndrome
T11725 27275-27277 RB denotes so
T11726 27278-27284 VBN denotes called
T11727 27277-27278 HYPH denotes -
T11728 27285-27294 JJ denotes metabolic
T11729 27303-27304 . denotes .
T11730 27304-27478 sentence denotes Several groups, including ours, have reported the advantage of combining traditional genetics with genome-wide gene expression analysis for the dissection of complex traits.
T11731 27305-27312 JJ denotes Several
T11732 27313-27319 NNS denotes groups
T11733 27342-27350 VBN denotes reported
T11734 27319-27321 , denotes ,
T11735 27321-27330 VBG denotes including
T11736 27331-27335 PRP denotes ours
T11737 27335-27337 , denotes ,
T11738 27337-27341 VBP denotes have
T11739 27351-27354 DT denotes the
T11740 27355-27364 NN denotes advantage
T11741 27365-27367 IN denotes of
T11742 27368-27377 VBG denotes combining
T11743 27378-27389 JJ denotes traditional
T11744 27390-27398 NN denotes genetics
T11745 27399-27403 IN denotes with
T11746 27404-27410 NN denotes genome
T11747 27411-27415 JJ denotes wide
T11748 27410-27411 HYPH denotes -
T11749 27432-27440 NN denotes analysis
T11750 27416-27420 NN denotes gene
T11751 27421-27431 NN denotes expression
T11752 27441-27444 IN denotes for
T11753 27445-27448 DT denotes the
T11754 27449-27459 NN denotes dissection
T11755 27460-27462 IN denotes of
T11756 27463-27470 JJ denotes complex
T11757 27471-27477 NNS denotes traits
T11758 27477-27478 . denotes .
T11759 27478-27690 sentence denotes This study improved on past models by including over 300 animals (three times the size of previous studies) of both sexes, allowing for the incorporation of sex-specific effects on underlying genetic regulation.
T11760 27479-27483 DT denotes This
T11761 27484-27489 NN denotes study
T11762 27490-27498 VBD denotes improved
T11763 27499-27501 IN denotes on
T11764 27502-27506 JJ denotes past
T11765 27507-27513 NNS denotes models
T11766 27514-27516 IN denotes by
T11767 27517-27526 VBG denotes including
T11768 27527-27531 IN denotes over
T11769 27532-27535 CD denotes 300
T11770 27536-27543 NNS denotes animals
T11771 27544-27545 -LRB- denotes (
T11772 27561-27565 NN denotes size
T11773 27545-27550 CD denotes three
T11774 27551-27556 NNS denotes times
T11775 27557-27560 DT denotes the
T11776 27566-27568 IN denotes of
T11777 27569-27577 JJ denotes previous
T11778 27578-27585 NNS denotes studies
T11779 27585-27586 -RRB- denotes )
T11780 27587-27589 IN denotes of
T11781 27590-27594 DT denotes both
T11782 27595-27600 NNS denotes sexes
T11783 27600-27602 , denotes ,
T11784 27602-27610 VBG denotes allowing
T11785 27611-27614 IN denotes for
T11786 27615-27618 DT denotes the
T11787 27619-27632 NN denotes incorporation
T11788 27633-27635 IN denotes of
T11789 27636-27639 NN denotes sex
T11790 27640-27648 JJ denotes specific
T11791 27639-27640 HYPH denotes -
T11792 27649-27656 NNS denotes effects
T11793 27657-27659 IN denotes on
T11794 27660-27670 VBG denotes underlying
T11795 27679-27689 NN denotes regulation
T11796 27671-27678 JJ denotes genetic
T11797 27689-27690 . denotes .
T13776 27692-27703 JJ denotes Significant
T13777 27708-27712 NN denotes Bias
T13778 27704-27707 NN denotes Sex
T13779 27713-27715 IN denotes in
T13780 27716-27719 DT denotes the
T13781 27720-27730 NN denotes Regulation
T13782 27731-27733 IN denotes of
T13783 27734-27738 CC denotes Both
T13784 27747-27753 NNS denotes Traits
T13785 27739-27746 JJ denotes Complex
T13786 27754-27757 CC denotes and
T13787 27758-27762 NN denotes Gene
T13788 27763-27773 NN denotes Expression
T13789 27773-28005 sentence denotes Given the known dichotomy between females and males in the susceptibility and control of obesity, this study was designed to sufficiently power the detection of significant QTLs for this and other traits with sex-dependent effects.
T13790 27774-27779 VBN denotes Given
T13791 27887-27895 VBN denotes designed
T13792 27780-27783 DT denotes the
T13793 27790-27799 NN denotes dichotomy
T13794 27784-27789 JJ denotes known
T13795 27800-27807 IN denotes between
T13796 27808-27815 NNS denotes females
T13797 27816-27819 CC denotes and
T13798 27820-27825 NNS denotes males
T13799 27826-27828 IN denotes in
T13800 27829-27832 DT denotes the
T13801 27833-27847 NN denotes susceptibility
T13802 27848-27851 CC denotes and
T13803 27852-27859 NN denotes control
T13804 27860-27862 IN denotes of
T13805 27863-27870 NN denotes obesity
T13806 27870-27872 , denotes ,
T13807 27872-27876 DT denotes this
T13808 27877-27882 NN denotes study
T13809 27883-27886 VBD denotes was
T13810 27896-27898 TO denotes to
T13811 27912-27917 VB denotes power
T13812 27899-27911 RB denotes sufficiently
T13813 27918-27921 DT denotes the
T13814 27922-27931 NN denotes detection
T13815 27932-27934 IN denotes of
T13816 27935-27946 JJ denotes significant
T13817 27947-27951 NNS denotes QTLs
T13818 27952-27955 IN denotes for
T13819 27956-27960 DT denotes this
T13820 27961-27964 CC denotes and
T13821 27965-27970 JJ denotes other
T13822 27971-27977 NNS denotes traits
T13823 27978-27982 IN denotes with
T13824 27983-27986 NN denotes sex
T13825 27987-27996 JJ denotes dependent
T13826 27986-27987 HYPH denotes -
T13827 27997-28004 NNS denotes effects
T13828 28004-28005 . denotes .
T13829 28005-28112 sentence denotes Note, however, that these effects can extend to traits without overall mean differences between the sexes.
T13830 28006-28010 VB denotes Note
T13831 28010-28012 , denotes ,
T13832 28012-28019 RB denotes however
T13833 28019-28021 , denotes ,
T13834 28021-28025 IN denotes that
T13835 28044-28050 VB denotes extend
T13836 28026-28031 DT denotes these
T13837 28032-28039 NNS denotes effects
T13838 28040-28043 MD denotes can
T13839 28051-28053 IN denotes to
T13840 28054-28060 NNS denotes traits
T13841 28061-28068 IN denotes without
T13842 28069-28076 JJ denotes overall
T13843 28082-28093 NNS denotes differences
T13844 28077-28081 NN denotes mean
T13845 28094-28101 IN denotes between
T13846 28102-28105 DT denotes the
T13847 28106-28111 NNS denotes sexes
T13848 28111-28112 . denotes .
T13849 28112-28249 sentence denotes Previous studies have described the advantages of performing QTL analysis both with and without sex as an interactive covariate [22–25].
T13850 28113-28121 JJ denotes Previous
T13851 28122-28129 NNS denotes studies
T13852 28135-28144 VBN denotes described
T13853 28130-28134 VBP denotes have
T13854 28145-28148 DT denotes the
T13855 28149-28159 NNS denotes advantages
T13856 28160-28162 IN denotes of
T13857 28163-28173 VBG denotes performing
T13858 28174-28177 NN denotes QTL
T13859 28178-28186 NN denotes analysis
T13860 28187-28191 CC denotes both
T13861 28192-28196 IN denotes with
T13862 28197-28200 CC denotes and
T13863 28201-28208 IN denotes without
T13864 28209-28212 NN denotes sex
T13865 28213-28215 IN denotes as
T13866 28216-28218 DT denotes an
T13867 28231-28240 NN denotes covariate
T13868 28219-28230 JJ denotes interactive
T13869 28241-28242 -LRB- denotes [
T13870 28242-28244 CD denotes 22
T13871 28244-28245 SYM denotes –
T13872 28245-28247 CD denotes 25
T13873 28247-28248 -RRB- denotes ]
T13874 28248-28249 . denotes .
T13875 28249-28451 sentence denotes Analyzing the sexes separately is suboptimal since it reduces sample size in both groups, thus reducing power to detect main QTL effects, as demonstrated by our genome scan of Chromosome 5 (Figure 1B).
T13876 28250-28259 VBG denotes Analyzing
T13877 28281-28283 VBZ denotes is
T13878 28260-28263 DT denotes the
T13879 28264-28269 NNS denotes sexes
T13880 28270-28280 RB denotes separately
T13881 28284-28294 JJ denotes suboptimal
T13882 28295-28300 IN denotes since
T13883 28304-28311 VBZ denotes reduces
T13884 28301-28303 PRP denotes it
T13885 28312-28318 NN denotes sample
T13886 28319-28323 NN denotes size
T13887 28324-28326 IN denotes in
T13888 28327-28331 DT denotes both
T13889 28332-28338 NNS denotes groups
T13890 28338-28340 , denotes ,
T13891 28340-28344 RB denotes thus
T13892 28345-28353 VBG denotes reducing
T13893 28354-28359 NN denotes power
T13894 28360-28362 TO denotes to
T13895 28363-28369 VB denotes detect
T13896 28370-28374 JJ denotes main
T13897 28379-28386 NNS denotes effects
T13898 28375-28378 NN denotes QTL
T13899 28386-28388 , denotes ,
T13900 28388-28390 IN denotes as
T13901 28391-28403 VBN denotes demonstrated
T13902 28404-28406 IN denotes by
T13903 28407-28410 PRP$ denotes our
T13904 28418-28422 NN denotes scan
T13905 28411-28417 NN denotes genome
T13906 28423-28425 IN denotes of
T13907 28426-28436 NN denotes Chromosome
T13908 28437-28438 CD denotes 5
T13909 28439-28440 -LRB- denotes (
T13910 28447-28449 NN denotes 1B
T13911 28440-28446 NN denotes Figure
T13912 28449-28450 -RRB- denotes )
T13913 28450-28451 . denotes .
T13914 28451-28654 sentence denotes Furthermore, separate analyses would not allow for the detection of QTLs that have opposing, or sex-antagonistic, effects in females and males and would hinder the detection of QTLs specific to one sex.
T13915 28452-28463 RB denotes Furthermore
T13916 28493-28498 VB denotes allow
T13917 28463-28465 , denotes ,
T13918 28465-28473 JJ denotes separate
T13919 28474-28482 NNS denotes analyses
T13920 28483-28488 MD denotes would
T13921 28489-28492 RB denotes not
T13922 28499-28502 IN denotes for
T13923 28503-28506 DT denotes the
T13924 28507-28516 NN denotes detection
T13925 28517-28519 IN denotes of
T13926 28520-28524 NNS denotes QTLs
T13927 28525-28529 WDT denotes that
T13928 28530-28534 VBP denotes have
T13929 28535-28543 VBG denotes opposing
T13930 28566-28573 NNS denotes effects
T13931 28543-28545 , denotes ,
T13932 28545-28547 CC denotes or
T13933 28548-28551 NN denotes sex
T13934 28552-28564 JJ denotes antagonistic
T13935 28551-28552 HYPH denotes -
T13936 28564-28566 , denotes ,
T13937 28574-28576 IN denotes in
T13938 28577-28584 NNS denotes females
T13939 28585-28588 CC denotes and
T13940 28589-28594 NNS denotes males
T13941 28595-28598 CC denotes and
T13942 28599-28604 MD denotes would
T13943 28605-28611 VB denotes hinder
T13944 28612-28615 DT denotes the
T13945 28616-28625 NN denotes detection
T13946 28626-28628 IN denotes of
T13947 28629-28633 NNS denotes QTLs
T13948 28634-28642 JJ denotes specific
T13949 28643-28645 IN denotes to
T13950 28646-28649 CD denotes one
T13951 28650-28653 NN denotes sex
T13952 28653-28654 . denotes .
T13953 28654-28757 sentence denotes Accordingly, we detected five cQTLs for the gonadal fat mass trait on Chromosomes 1, 3, 5, 11, and 19.
T13954 28655-28666 RB denotes Accordingly
T13955 28671-28679 VBD denotes detected
T13956 28666-28668 , denotes ,
T13957 28668-28670 PRP denotes we
T13958 28680-28684 CD denotes five
T13959 28685-28690 NNS denotes cQTLs
T13960 28691-28694 IN denotes for
T13961 28695-28698 DT denotes the
T13962 28716-28721 NN denotes trait
T13963 28699-28706 JJ denotes gonadal
T13964 28711-28715 NN denotes mass
T13965 28707-28710 NN denotes fat
T13966 28722-28724 IN denotes on
T13967 28725-28736 NNS denotes Chromosomes
T13968 28737-28738 CD denotes 1
T13969 28738-28740 , denotes ,
T13970 28740-28741 CD denotes 3
T13971 28741-28743 , denotes ,
T13972 28743-28744 CD denotes 5
T13973 28744-28746 , denotes ,
T13974 28746-28748 CD denotes 11
T13975 28748-28750 , denotes ,
T13976 28750-28753 CC denotes and
T13977 28754-28756 CD denotes 19
T13978 28756-28757 . denotes .
T13979 28757-28930 sentence denotes The detection of all five cQTLs was “driven” by the larger effect in females, with significant improvement by the incorporation of sex*additive and sex*dominant parameters.
T13980 28758-28761 DT denotes The
T13981 28762-28771 NN denotes detection
T13982 28795-28801 VBN denotes driven
T13983 28772-28774 IN denotes of
T13984 28775-28778 DT denotes all
T13985 28784-28789 NNS denotes cQTLs
T13986 28779-28783 CD denotes five
T13987 28790-28793 VBD denotes was
T13988 28794-28795 `` denotes “
T13989 28801-28802 '' denotes ”
T13990 28803-28805 IN denotes by
T13991 28806-28809 DT denotes the
T13992 28817-28823 NN denotes effect
T13993 28810-28816 JJR denotes larger
T13994 28824-28826 IN denotes in
T13995 28827-28834 NNS denotes females
T13996 28834-28836 , denotes ,
T13997 28836-28840 IN denotes with
T13998 28841-28852 JJ denotes significant
T13999 28853-28864 NN denotes improvement
T14000 28865-28867 IN denotes by
T14001 28868-28871 DT denotes the
T14002 28872-28885 NN denotes incorporation
T14003 28886-28888 IN denotes of
T14004 28889-28892 NN denotes sex
T14005 28893-28901 JJ denotes additive
T14006 28892-28893 HYPH denotes *
T14007 28919-28929 NNS denotes parameters
T14008 28902-28905 CC denotes and
T14009 28906-28909 NN denotes sex
T14010 28910-28918 JJ denotes dominant
T14011 28909-28910 HYPH denotes *
T14012 28929-28930 . denotes .
T14013 28930-29179 sentence denotes QTLs associated with obesity, gonadal fat, and abdominal fat have been reported before overlapping with cQTLs on Chromosomes 1 [26–28], 5 [26,29], and 11 [19,29] reported here, whereas the cQTL on Chromosome 3 represents a novel QTL for this trait.
T14014 28931-28935 NNS denotes QTLs
T14015 29018-29029 VBG denotes overlapping
T14016 28936-28946 VBN denotes associated
T14017 28947-28951 IN denotes with
T14018 28952-28959 NN denotes obesity
T14019 28959-28961 , denotes ,
T14020 28961-28968 JJ denotes gonadal
T14021 28969-28972 NN denotes fat
T14022 28972-28974 , denotes ,
T14023 28974-28977 CC denotes and
T14024 28978-28987 JJ denotes abdominal
T14025 28988-28991 NN denotes fat
T14026 28992-28996 VBP denotes have
T14027 28997-29001 VBN denotes been
T14028 29002-29010 VBN denotes reported
T14029 29011-29017 RB denotes before
T14030 29030-29034 IN denotes with
T14031 29035-29040 NNS denotes cQTLs
T14032 29041-29043 IN denotes on
T14033 29044-29055 NNS denotes Chromosomes
T14034 29056-29057 CD denotes 1
T14035 29058-29059 -LRB- denotes [
T14036 29059-29061 CD denotes 26
T14037 29061-29062 SYM denotes –
T14038 29062-29064 CD denotes 28
T14039 29064-29065 -RRB- denotes ]
T14040 29065-29067 , denotes ,
T14041 29067-29068 CD denotes 5
T14042 29069-29070 -LRB- denotes [
T14043 29073-29075 CD denotes 29
T14044 29070-29072 CD denotes 26
T14045 29072-29073 , denotes ,
T14046 29075-29076 -RRB- denotes ]
T14047 29076-29078 , denotes ,
T14048 29078-29081 CC denotes and
T14049 29082-29084 CD denotes 11
T14050 29085-29086 -LRB- denotes [
T14051 29089-29091 CD denotes 29
T14052 29086-29088 CD denotes 19
T14053 29088-29089 , denotes ,
T14054 29091-29092 -RRB- denotes ]
T14055 29093-29101 VBN denotes reported
T14056 29102-29106 RB denotes here
T14057 29106-29108 , denotes ,
T14058 29108-29115 IN denotes whereas
T14059 29141-29151 VBZ denotes represents
T14060 29116-29119 DT denotes the
T14061 29120-29124 NN denotes cQTL
T14062 29125-29127 IN denotes on
T14063 29128-29138 NN denotes Chromosome
T14064 29139-29140 CD denotes 3
T14065 29152-29153 DT denotes a
T14066 29160-29163 NN denotes QTL
T14067 29154-29159 JJ denotes novel
T14068 29164-29167 IN denotes for
T14069 29168-29172 DT denotes this
T14070 29173-29178 NN denotes trait
T14071 29178-29179 . denotes .
T14072 29179-29395 sentence denotes The Chromosome 19 cQTL for fat mass was recently reported by us [5] in the BXD intercross F2 progeny from the strains B6 and DBA (which shares the same haplotype at this region as the C3H strain used in this study).
T14073 29180-29183 DT denotes The
T14074 29198-29202 NN denotes cQTL
T14075 29184-29194 NN denotes Chromosome
T14076 29195-29197 CD denotes 19
T14077 29229-29237 VBN denotes reported
T14078 29203-29206 IN denotes for
T14079 29207-29210 NN denotes fat
T14080 29211-29215 NN denotes mass
T14081 29216-29219 VBD denotes was
T14082 29220-29228 RB denotes recently
T14083 29238-29240 IN denotes by
T14084 29241-29243 PRP denotes us
T14085 29244-29245 -LRB- denotes [
T14086 29245-29246 CD denotes 5
T14087 29246-29247 -RRB- denotes ]
T14088 29248-29250 IN denotes in
T14089 29251-29254 DT denotes the
T14090 29273-29280 NN denotes progeny
T14091 29255-29258 NN denotes BXD
T14092 29259-29269 NN denotes intercross
T14093 29270-29272 NN denotes F2
T14094 29281-29285 IN denotes from
T14095 29286-29289 DT denotes the
T14096 29290-29297 NNS denotes strains
T14097 29298-29300 NN denotes B6
T14098 29301-29304 CC denotes and
T14099 29305-29308 NN denotes DBA
T14100 29309-29310 -LRB- denotes (
T14101 29310-29315 WDT denotes which
T14102 29316-29322 VBZ denotes shares
T14103 29323-29326 DT denotes the
T14104 29332-29341 NN denotes haplotype
T14105 29327-29331 JJ denotes same
T14106 29342-29344 IN denotes at
T14107 29345-29349 DT denotes this
T14108 29350-29356 NN denotes region
T14109 29357-29359 IN denotes as
T14110 29360-29363 DT denotes the
T14111 29368-29374 NN denotes strain
T14112 29364-29367 NN denotes C3H
T14113 29375-29379 VBN denotes used
T14114 29380-29382 IN denotes in
T14115 29383-29387 DT denotes this
T14116 29388-29393 NN denotes study
T14117 29393-29394 -RRB- denotes )
T14118 29394-29395 . denotes .
T14119 29395-29583 sentence denotes Interestingly, significant heritability and genetic regulation was seen in this F2 population despite the hyperlipidemic, proinflammatory ApoE−/− background and the high-fat Western diet.
T14120 29396-29409 RB denotes Interestingly
T14121 29463-29467 VBN denotes seen
T14122 29409-29411 , denotes ,
T14123 29411-29422 JJ denotes significant
T14124 29423-29435 NN denotes heritability
T14125 29436-29439 CC denotes and
T14126 29440-29447 JJ denotes genetic
T14127 29448-29458 NN denotes regulation
T14128 29459-29462 VBD denotes was
T14129 29468-29470 IN denotes in
T14130 29471-29475 DT denotes this
T14131 29479-29489 NN denotes population
T14132 29476-29478 NN denotes F2
T14133 29490-29497 IN denotes despite
T14134 29498-29501 DT denotes the
T14135 29542-29552 NN denotes background
T14136 29502-29516 JJ denotes hyperlipidemic
T14137 29516-29518 , denotes ,
T14138 29518-29533 JJ denotes proinflammatory
T14139 29534-29538 NN denotes ApoE
T14140 29538-29539 SYM denotes −
T14141 29539-29540 HYPH denotes /
T14142 29540-29541 SYM denotes −
T14143 29553-29556 CC denotes and
T14144 29557-29560 DT denotes the
T14145 29578-29582 NN denotes diet
T14146 29561-29565 JJ denotes high
T14147 29566-29569 NN denotes fat
T14148 29565-29566 HYPH denotes -
T14149 29570-29577 NNP denotes Western
T14150 29582-29583 . denotes .
T14151 29583-29689 sentence denotes This background possesses several advantages, such as allowing the modeling of human-like disease states.
T14152 29584-29588 DT denotes This
T14153 29589-29599 NN denotes background
T14154 29600-29609 VBZ denotes possesses
T14155 29610-29617 JJ denotes several
T14156 29618-29628 NNS denotes advantages
T14157 29628-29630 , denotes ,
T14158 29630-29634 JJ denotes such
T14159 29635-29637 IN denotes as
T14160 29638-29646 VBG denotes allowing
T14161 29647-29650 DT denotes the
T14162 29651-29659 NN denotes modeling
T14163 29660-29662 IN denotes of
T14164 29663-29668 JJ denotes human
T14165 29669-29673 JJ denotes like
T14166 29668-29669 HYPH denotes -
T14167 29682-29688 NNS denotes states
T14168 29674-29681 NN denotes disease
T14169 29688-29689 . denotes .
T14170 29689-29877 sentence denotes The predominantly female-driven effects of the five cQTLs likely reflect the significant effect of differential gonadal hormone secretions on the genetic regulation of this complex trait.
T14171 29690-29693 DT denotes The
T14172 29722-29729 NNS denotes effects
T14173 29694-29707 RB denotes predominantly
T14174 29715-29721 VBN denotes driven
T14175 29708-29714 JJ denotes female
T14176 29714-29715 HYPH denotes -
T14177 29755-29762 VBP denotes reflect
T14178 29730-29732 IN denotes of
T14179 29733-29736 DT denotes the
T14180 29742-29747 NNS denotes cQTLs
T14181 29737-29741 CD denotes five
T14182 29748-29754 RB denotes likely
T14183 29763-29766 DT denotes the
T14184 29779-29785 NN denotes effect
T14185 29767-29778 JJ denotes significant
T14186 29786-29788 IN denotes of
T14187 29789-29801 JJ denotes differential
T14188 29818-29828 NNS denotes secretions
T14189 29802-29809 JJ denotes gonadal
T14190 29810-29817 NN denotes hormone
T14191 29829-29831 IN denotes on
T14192 29832-29835 DT denotes the
T14193 29844-29854 NN denotes regulation
T14194 29836-29843 JJ denotes genetic
T14195 29855-29857 IN denotes of
T14196 29858-29862 DT denotes this
T14197 29871-29876 NN denotes trait
T14198 29863-29870 JJ denotes complex
T14199 29876-29877 . denotes .
T14200 29877-29943 sentence denotes The identification of genes underlying cQTLs remains a challenge.
T14201 29878-29881 DT denotes The
T14202 29882-29896 NN denotes identification
T14203 29923-29930 VBZ denotes remains
T14204 29897-29899 IN denotes of
T14205 29900-29905 NNS denotes genes
T14206 29906-29916 VBG denotes underlying
T14207 29917-29922 NNS denotes cQTLs
T14208 29931-29932 DT denotes a
T14209 29933-29942 NN denotes challenge
T14210 29942-29943 . denotes .
T14211 29943-30180 sentence denotes The widespread availability of genome-wide expression analysis has begun to address this by providing a snapshot of transcription in relevant organs and thus providing initial information for which genes can differentiate a given trait.
T14212 29944-29947 DT denotes The
T14213 29959-29971 NN denotes availability
T14214 29948-29958 JJ denotes widespread
T14215 30011-30016 VBN denotes begun
T14216 29972-29974 IN denotes of
T14217 29975-29981 NN denotes genome
T14218 29982-29986 JJ denotes wide
T14219 29981-29982 HYPH denotes -
T14220 29998-30006 NN denotes analysis
T14221 29987-29997 NN denotes expression
T14222 30007-30010 VBZ denotes has
T14223 30017-30019 TO denotes to
T14224 30020-30027 VB denotes address
T14225 30028-30032 DT denotes this
T14226 30033-30035 IN denotes by
T14227 30036-30045 VBG denotes providing
T14228 30046-30047 DT denotes a
T14229 30048-30056 NN denotes snapshot
T14230 30057-30059 IN denotes of
T14231 30060-30073 NN denotes transcription
T14232 30074-30076 IN denotes in
T14233 30077-30085 JJ denotes relevant
T14234 30086-30092 NNS denotes organs
T14235 30093-30096 CC denotes and
T14236 30097-30101 RB denotes thus
T14237 30102-30111 VBG denotes providing
T14238 30112-30119 JJ denotes initial
T14239 30120-30131 NN denotes information
T14240 30132-30135 IN denotes for
T14241 30136-30141 WDT denotes which
T14242 30142-30147 NNS denotes genes
T14243 30152-30165 VB denotes differentiate
T14244 30148-30151 MD denotes can
T14245 30166-30167 DT denotes a
T14246 30174-30179 NN denotes trait
T14247 30168-30173 JJ denotes given
T14248 30179-30180 . denotes .
T14249 30180-30330 sentence denotes Furthermore, by treating transcript levels as quantitative traits, we can map the genetic regulation underlying differential gene expression (eQTLs).
T14250 30181-30192 RB denotes Furthermore
T14251 30255-30258 VB denotes map
T14252 30192-30194 , denotes ,
T14253 30194-30196 IN denotes by
T14254 30197-30205 VBG denotes treating
T14255 30206-30216 NN denotes transcript
T14256 30217-30223 NNS denotes levels
T14257 30224-30226 IN denotes as
T14258 30227-30239 JJ denotes quantitative
T14259 30240-30246 NNS denotes traits
T14260 30246-30248 , denotes ,
T14261 30248-30250 PRP denotes we
T14262 30251-30254 MD denotes can
T14263 30259-30262 DT denotes the
T14264 30271-30281 NN denotes regulation
T14265 30263-30270 JJ denotes genetic
T14266 30282-30292 VBG denotes underlying
T14267 30293-30305 JJ denotes differential
T14268 30311-30321 NN denotes expression
T14269 30306-30310 NN denotes gene
T14270 30322-30323 -LRB- denotes (
T14271 30323-30328 NNS denotes eQTLs
T14272 30328-30329 -RRB- denotes )
T14273 30329-30330 . denotes .
T14274 30330-30449 sentence denotes Those eQTLs that have cis-acting variations affecting their transcription are potential candidate genes for the trait.
T14275 30331-30336 DT denotes Those
T14276 30337-30342 NNS denotes eQTLs
T14277 30405-30408 VBP denotes are
T14278 30343-30347 WDT denotes that
T14279 30348-30352 VBP denotes have
T14280 30353-30356 NN denotes cis
T14281 30357-30363 VBG denotes acting
T14282 30356-30357 HYPH denotes -
T14283 30364-30374 NNS denotes variations
T14284 30375-30384 VBG denotes affecting
T14285 30385-30390 PRP$ denotes their
T14286 30391-30404 NN denotes transcription
T14287 30409-30418 JJ denotes potential
T14288 30429-30434 NNS denotes genes
T14289 30419-30428 NN denotes candidate
T14290 30435-30438 IN denotes for
T14291 30439-30442 DT denotes the
T14292 30443-30448 NN denotes trait
T14293 30448-30449 . denotes .
T14294 30449-30590 sentence denotes At a single trait, genome-wide significance level of 0.05, we detected 6,676 eQTLs representing 4,998 genes, of which 2,118 were cis-acting.
T14295 30450-30452 IN denotes At
T14296 30512-30520 VBD denotes detected
T14297 30453-30454 DT denotes a
T14298 30494-30499 NN denotes level
T14299 30455-30461 JJ denotes single
T14300 30462-30467 NN denotes trait
T14301 30467-30469 , denotes ,
T14302 30469-30475 NN denotes genome
T14303 30476-30480 JJ denotes wide
T14304 30475-30476 HYPH denotes -
T14305 30481-30493 NN denotes significance
T14306 30500-30502 IN denotes of
T14307 30503-30507 CD denotes 0.05
T14308 30507-30509 , denotes ,
T14309 30509-30511 PRP denotes we
T14310 30521-30526 CD denotes 6,676
T14311 30527-30532 NNS denotes eQTLs
T14312 30533-30545 VBG denotes representing
T14313 30546-30551 CD denotes 4,998
T14314 30552-30557 NNS denotes genes
T14315 30557-30559 , denotes ,
T14316 30559-30561 IN denotes of
T14317 30574-30578 VBD denotes were
T14318 30562-30567 WDT denotes which
T14319 30568-30573 CD denotes 2,118
T14320 30579-30582 NN denotes cis
T14321 30583-30589 VBG denotes acting
T14322 30582-30583 HYPH denotes -
T14323 30589-30590 . denotes .
T14324 30590-30807 sentence denotes At increased thresholds, the proportion of cis-eQTLs increased, which is in good agreement with previous studies [5,15] and likely reflects the increased power to detect cis-acting variations affecting transcription.
T14325 30591-30593 IN denotes At
T14326 30644-30653 VBD denotes increased
T14327 30594-30603 VBN denotes increased
T14328 30604-30614 NNS denotes thresholds
T14329 30614-30616 , denotes ,
T14330 30616-30619 DT denotes the
T14331 30620-30630 NN denotes proportion
T14332 30631-30633 IN denotes of
T14333 30634-30637 NN denotes cis
T14334 30638-30643 NNS denotes eQTLs
T14335 30637-30638 HYPH denotes -
T14336 30653-30655 , denotes ,
T14337 30655-30660 WDT denotes which
T14338 30661-30663 VBZ denotes is
T14339 30664-30666 IN denotes in
T14340 30667-30671 JJ denotes good
T14341 30672-30681 NN denotes agreement
T14342 30682-30686 IN denotes with
T14343 30687-30695 JJ denotes previous
T14344 30696-30703 NNS denotes studies
T14345 30704-30705 -LRB- denotes [
T14346 30707-30709 CD denotes 15
T14347 30705-30706 CD denotes 5
T14348 30706-30707 , denotes ,
T14349 30709-30710 -RRB- denotes ]
T14350 30711-30714 CC denotes and
T14351 30715-30721 RB denotes likely
T14352 30722-30730 VBZ denotes reflects
T14353 30731-30734 DT denotes the
T14354 30745-30750 NN denotes power
T14355 30735-30744 VBN denotes increased
T14356 30751-30753 TO denotes to
T14357 30754-30760 VB denotes detect
T14358 30761-30764 NN denotes cis
T14359 30765-30771 VBG denotes acting
T14360 30764-30765 HYPH denotes -
T14361 30772-30782 NNS denotes variations
T14362 30783-30792 VBG denotes affecting
T14363 30793-30806 NN denotes transcription
T14364 30806-30807 . denotes .
T14365 30807-30885 sentence denotes Of all 6,676 significant eQTLs, 1,166 possessed significant sex interactions.
T14366 30808-30810 IN denotes Of
T14367 30846-30855 VBD denotes possessed
T14368 30811-30814 DT denotes all
T14369 30833-30838 NNS denotes eQTLs
T14370 30815-30820 CD denotes 6,676
T14371 30821-30832 JJ denotes significant
T14372 30838-30840 , denotes ,
T14373 30840-30845 CD denotes 1,166
T14374 30856-30867 JJ denotes significant
T14375 30872-30884 NNS denotes interactions
T14376 30868-30871 NN denotes sex
T14377 30884-30885 . denotes .
T14378 30885-31077 sentence denotes Of these, 304 were cis and 852 were trans, suggesting that only a minority of the sex-specific effects on the regulation of gene expression occur through polymorphisms within the gene itself.
T14379 30886-30888 IN denotes Of
T14380 30900-30904 VBD denotes were
T14381 30889-30894 DT denotes these
T14382 30894-30896 , denotes ,
T14383 30896-30899 CD denotes 304
T14384 30905-30908 NN denotes cis
T14385 30909-30912 CC denotes and
T14386 30913-30916 CD denotes 852
T14387 30917-30921 VBD denotes were
T14388 30922-30927 NN denotes trans
T14389 30927-30929 , denotes ,
T14390 30929-30939 VBG denotes suggesting
T14391 30940-30944 IN denotes that
T14392 31026-31031 VBP denotes occur
T14393 30945-30949 RB denotes only
T14394 30952-30960 NN denotes minority
T14395 30950-30951 DT denotes a
T14396 30961-30963 IN denotes of
T14397 30964-30967 DT denotes the
T14398 30981-30988 NNS denotes effects
T14399 30968-30971 NN denotes sex
T14400 30972-30980 JJ denotes specific
T14401 30971-30972 HYPH denotes -
T14402 30989-30991 IN denotes on
T14403 30992-30995 DT denotes the
T14404 30996-31006 NN denotes regulation
T14405 31007-31009 IN denotes of
T14406 31010-31014 NN denotes gene
T14407 31015-31025 NN denotes expression
T14408 31032-31039 IN denotes through
T14409 31040-31053 NNS denotes polymorphisms
T14410 31054-31060 IN denotes within
T14411 31061-31064 DT denotes the
T14412 31065-31069 NN denotes gene
T14413 31070-31076 PRP denotes itself
T14414 31076-31077 . denotes .
T14415 31077-31227 sentence denotes Rather, underlying genetic regulation of most transcripts is the result of interactions between trans loci and sex-specific factors (e.g., hormones).
T14416 31078-31084 RB denotes Rather
T14417 31136-31138 VBZ denotes is
T14418 31084-31086 , denotes ,
T14419 31086-31096 VBG denotes underlying
T14420 31105-31115 NN denotes regulation
T14421 31097-31104 JJ denotes genetic
T14422 31116-31118 IN denotes of
T14423 31119-31123 JJS denotes most
T14424 31124-31135 NNS denotes transcripts
T14425 31139-31142 DT denotes the
T14426 31143-31149 NN denotes result
T14427 31150-31152 IN denotes of
T14428 31153-31165 NNS denotes interactions
T14429 31166-31173 IN denotes between
T14430 31174-31179 NN denotes trans
T14431 31180-31184 NNS denotes loci
T14432 31185-31188 CC denotes and
T14433 31189-31192 NN denotes sex
T14434 31193-31201 JJ denotes specific
T14435 31192-31193 HYPH denotes -
T14436 31202-31209 NNS denotes factors
T14437 31210-31211 -LRB- denotes (
T14438 31211-31215 FW denotes e.g.
T14439 31217-31225 NNS denotes hormones
T14440 31215-31217 , denotes ,
T14441 31225-31226 -RRB- denotes )
T14442 31226-31227 . denotes .
T14443 31227-31371 sentence denotes As with cQTLs, sex bias in the predominantly trans genetic regulation of gene expression is likely secondary to different sex hormone profiles.
T14444 31228-31230 IN denotes As
T14445 31317-31319 VBZ denotes is
T14446 31231-31235 IN denotes with
T14447 31236-31241 NNS denotes cQTLs
T14448 31241-31243 , denotes ,
T14449 31243-31246 NN denotes sex
T14450 31247-31251 NN denotes bias
T14451 31252-31254 IN denotes in
T14452 31255-31258 DT denotes the
T14453 31287-31297 NN denotes regulation
T14454 31259-31272 RB denotes predominantly
T14455 31273-31278 JJ denotes trans
T14456 31279-31286 JJ denotes genetic
T14457 31298-31300 IN denotes of
T14458 31301-31305 NN denotes gene
T14459 31306-31316 NN denotes expression
T14460 31320-31326 RB denotes likely
T14461 31327-31336 JJ denotes secondary
T14462 31337-31339 IN denotes to
T14463 31340-31349 JJ denotes different
T14464 31362-31370 NNS denotes profiles
T14465 31350-31353 NN denotes sex
T14466 31354-31361 NN denotes hormone
T14467 31370-31371 . denotes .
T14468 31371-31580 sentence denotes Recently, using a similar dataset, our group demonstrated that significant cis-eQTLs (p < 5 × 10−5) largely represent true positives [30] and are enriched for highly polymorphic regions over the mouse genome.
T14469 31372-31380 RB denotes Recently
T14470 31417-31429 VBD denotes demonstrated
T14471 31380-31382 , denotes ,
T14472 31382-31387 VBG denotes using
T14473 31388-31389 DT denotes a
T14474 31398-31405 NN denotes dataset
T14475 31390-31397 JJ denotes similar
T14476 31405-31407 , denotes ,
T14477 31407-31410 PRP$ denotes our
T14478 31411-31416 NN denotes group
T14479 31430-31434 IN denotes that
T14480 31480-31489 VBP denotes represent
T14481 31435-31446 JJ denotes significant
T14482 31451-31456 NNS denotes eQTLs
T14483 31447-31450 NN denotes cis
T14484 31450-31451 HYPH denotes -
T14485 31457-31458 -LRB- denotes (
T14486 31462-31463 CD denotes 5
T14487 31458-31459 NN denotes p
T14488 31460-31461 SYM denotes <
T14489 31464-31465 SYM denotes ×
T14490 31466-31468 CD denotes 10
T14491 31469-31470 CD denotes 5
T14492 31468-31469 SYM denotes −
T14493 31470-31471 -RRB- denotes )
T14494 31472-31479 RB denotes largely
T14495 31490-31494 JJ denotes true
T14496 31495-31504 NNS denotes positives
T14497 31505-31506 -LRB- denotes [
T14498 31506-31508 CD denotes 30
T14499 31508-31509 -RRB- denotes ]
T14500 31510-31513 CC denotes and
T14501 31514-31517 VBP denotes are
T14502 31518-31526 JJ denotes enriched
T14503 31527-31530 IN denotes for
T14504 31531-31537 RB denotes highly
T14505 31538-31549 JJ denotes polymorphic
T14506 31550-31557 NNS denotes regions
T14507 31558-31562 IN denotes over
T14508 31563-31566 DT denotes the
T14509 31573-31579 NN denotes genome
T14510 31567-31572 NN denotes mouse
T14511 31579-31580 . denotes .
T14512 31580-31709 sentence denotes The cis-eQTLs presented in Table 5 overlap with one of the gonadal fat mass cQTLs and should be considered potential candidates.
T14513 31581-31584 DT denotes The
T14514 31589-31594 NNS denotes eQTLs
T14515 31585-31588 NN denotes cis
T14516 31588-31589 HYPH denotes -
T14517 31616-31623 VBP denotes overlap
T14518 31595-31604 VBN denotes presented
T14519 31605-31607 IN denotes in
T14520 31608-31613 NN denotes Table
T14521 31614-31615 CD denotes 5
T14522 31624-31628 IN denotes with
T14523 31629-31632 CD denotes one
T14524 31633-31635 IN denotes of
T14525 31636-31639 DT denotes the
T14526 31657-31662 NNS denotes cQTLs
T14527 31640-31647 JJ denotes gonadal
T14528 31652-31656 NN denotes mass
T14529 31648-31651 NN denotes fat
T14530 31663-31666 CC denotes and
T14531 31667-31673 MD denotes should
T14532 31677-31687 VBN denotes considered
T14533 31674-31676 VB denotes be
T14534 31688-31697 JJ denotes potential
T14535 31698-31708 NNS denotes candidates
T14536 31708-31709 . denotes .
T14537 31709-31887 sentence denotes Given the sex effects in the gonadal fat mass cQTLs, we reasoned that the cis-eQTLs with significant sex*additive and sex*dominant effects should receive priority consideration.
T14538 31710-31715 IN denotes Given
T14539 31766-31774 VBD denotes reasoned
T14540 31716-31719 DT denotes the
T14541 31724-31731 NNS denotes effects
T14542 31720-31723 NN denotes sex
T14543 31732-31734 IN denotes in
T14544 31735-31738 DT denotes the
T14545 31756-31761 NNS denotes cQTLs
T14546 31739-31746 JJ denotes gonadal
T14547 31751-31755 NN denotes mass
T14548 31747-31750 NN denotes fat
T14549 31761-31763 , denotes ,
T14550 31763-31765 PRP denotes we
T14551 31775-31779 IN denotes that
T14552 31856-31863 VB denotes receive
T14553 31780-31783 DT denotes the
T14554 31788-31793 NNS denotes eQTLs
T14555 31784-31787 NN denotes cis
T14556 31787-31788 HYPH denotes -
T14557 31794-31798 IN denotes with
T14558 31799-31810 JJ denotes significant
T14559 31841-31848 NNS denotes effects
T14560 31811-31814 NN denotes sex
T14561 31815-31823 JJ denotes additive
T14562 31814-31815 HYPH denotes *
T14563 31824-31827 CC denotes and
T14564 31828-31831 NN denotes sex
T14565 31832-31840 JJ denotes dominant
T14566 31831-31832 HYPH denotes *
T14567 31849-31855 MD denotes should
T14568 31864-31872 NN denotes priority
T14569 31873-31886 NN denotes consideration
T14570 31886-31887 . denotes .
T14571 31887-31998 sentence denotes The use of eQTLs to dissect cQTLs is a method still in its infancy, with uncertain efficacy and applicability.
T14572 31888-31891 DT denotes The
T14573 31892-31895 NN denotes use
T14574 31922-31924 VBZ denotes is
T14575 31896-31898 IN denotes of
T14576 31899-31904 NNS denotes eQTLs
T14577 31905-31907 TO denotes to
T14578 31908-31915 VB denotes dissect
T14579 31916-31921 NNS denotes cQTLs
T14580 31925-31926 DT denotes a
T14581 31927-31933 NN denotes method
T14582 31934-31939 RB denotes still
T14583 31940-31942 IN denotes in
T14584 31943-31946 PRP$ denotes its
T14585 31947-31954 NN denotes infancy
T14586 31954-31956 , denotes ,
T14587 31956-31960 IN denotes with
T14588 31961-31970 JJ denotes uncertain
T14589 31971-31979 NN denotes efficacy
T14590 31980-31983 CC denotes and
T14591 31984-31997 NN denotes applicability
T14592 31997-31998 . denotes .
T14593 31998-32113 sentence denotes Nevertheless, application of this analysis to this dataset provides some tantalizingly attractive candidate genes.
T14594 31999-32011 RB denotes Nevertheless
T14595 32058-32066 VBZ denotes provides
T14596 32011-32013 , denotes ,
T14597 32013-32024 NN denotes application
T14598 32025-32027 IN denotes of
T14599 32028-32032 DT denotes this
T14600 32033-32041 NN denotes analysis
T14601 32042-32044 IN denotes to
T14602 32045-32049 DT denotes this
T14603 32050-32057 NN denotes dataset
T14604 32067-32071 DT denotes some
T14605 32107-32112 NNS denotes genes
T14606 32072-32085 RB denotes tantalizingly
T14607 32086-32096 JJ denotes attractive
T14608 32097-32106 NN denotes candidate
T14609 32112-32113 . denotes .
T14610 32113-32390 sentence denotes One shortcoming of this approach, however, is that candidate genes are limited to those whose transcript expression levels vary in association with a nearby polymorphism that differs between the parental strains—in other words, genes with significant and detectable cis-eQTLs.
T14611 32114-32117 CD denotes One
T14612 32118-32129 NN denotes shortcoming
T14613 32157-32159 VBZ denotes is
T14614 32130-32132 IN denotes of
T14615 32133-32137 DT denotes this
T14616 32138-32146 NN denotes approach
T14617 32146-32148 , denotes ,
T14618 32148-32155 RB denotes however
T14619 32155-32157 , denotes ,
T14620 32160-32164 IN denotes that
T14621 32185-32192 VBN denotes limited
T14622 32165-32174 NN denotes candidate
T14623 32175-32180 NNS denotes genes
T14624 32181-32184 VBP denotes are
T14625 32193-32195 IN denotes to
T14626 32196-32201 DT denotes those
T14627 32202-32207 WP$ denotes whose
T14628 32230-32236 NNS denotes levels
T14629 32208-32218 NN denotes transcript
T14630 32219-32229 NN denotes expression
T14631 32237-32241 VBP denotes vary
T14632 32242-32244 IN denotes in
T14633 32245-32256 NN denotes association
T14634 32257-32261 IN denotes with
T14635 32262-32263 DT denotes a
T14636 32271-32283 NN denotes polymorphism
T14637 32264-32270 JJ denotes nearby
T14638 32284-32288 WDT denotes that
T14639 32289-32296 VBZ denotes differs
T14640 32297-32304 IN denotes between
T14641 32305-32308 DT denotes the
T14642 32318-32325 NNS denotes strains
T14643 32309-32317 JJ denotes parental
T14644 32325-32326 : denotes —
T14645 32326-32328 IN denotes in
T14646 32342-32347 NNS denotes genes
T14647 32329-32334 JJ denotes other
T14648 32335-32340 NNS denotes words
T14649 32340-32342 , denotes ,
T14650 32348-32352 IN denotes with
T14651 32353-32364 JJ denotes significant
T14652 32384-32389 NNS denotes eQTLs
T14653 32365-32368 CC denotes and
T14654 32369-32379 JJ denotes detectable
T14655 32380-32383 NN denotes cis
T14656 32383-32384 HYPH denotes -
T14657 32389-32390 . denotes .
T14658 32390-32581 sentence denotes However, it is not strictly necessary for candidate genes to have evidence of such linkage: polymorphisms underlying a trait cQTL can affect gene function or posttranslational modifications.
T14659 32391-32398 RB denotes However
T14660 32403-32405 VBZ denotes is
T14661 32398-32400 , denotes ,
T14662 32400-32402 PRP denotes it
T14663 32525-32531 VB denotes affect
T14664 32406-32409 RB denotes not
T14665 32410-32418 RB denotes strictly
T14666 32419-32428 JJ denotes necessary
T14667 32429-32432 IN denotes for
T14668 32452-32456 VB denotes have
T14669 32433-32442 NN denotes candidate
T14670 32443-32448 NNS denotes genes
T14671 32449-32451 TO denotes to
T14672 32457-32465 NN denotes evidence
T14673 32466-32468 IN denotes of
T14674 32469-32473 JJ denotes such
T14675 32474-32481 NN denotes linkage
T14676 32481-32483 : denotes :
T14677 32483-32496 NNS denotes polymorphisms
T14678 32497-32507 VBG denotes underlying
T14679 32508-32509 DT denotes a
T14680 32516-32520 NN denotes cQTL
T14681 32510-32515 NN denotes trait
T14682 32521-32524 MD denotes can
T14683 32532-32536 NN denotes gene
T14684 32537-32545 NN denotes function
T14685 32546-32548 CC denotes or
T14686 32549-32566 JJ denotes posttranslational
T14687 32567-32580 NNS denotes modifications
T14688 32580-32581 . denotes .
T14689 32581-32765 sentence denotes Nevertheless, several phenotypes are known to be regulated, at least partly, at the level of transcription or mRNA stability, which is exactly what our methods are designed to detect.
T14690 32582-32594 RB denotes Nevertheless
T14691 32619-32624 VBN denotes known
T14692 32594-32596 , denotes ,
T14693 32596-32603 JJ denotes several
T14694 32604-32614 NNS denotes phenotypes
T14695 32615-32618 VBP denotes are
T14696 32625-32627 TO denotes to
T14697 32631-32640 VBN denotes regulated
T14698 32628-32630 VB denotes be
T14699 32640-32642 , denotes ,
T14700 32642-32644 RB denotes at
T14701 32645-32650 RBS denotes least
T14702 32651-32657 RB denotes partly
T14703 32659-32661 IN denotes at
T14704 32657-32659 , denotes ,
T14705 32662-32665 DT denotes the
T14706 32666-32671 NN denotes level
T14707 32672-32674 IN denotes of
T14708 32675-32688 NN denotes transcription
T14709 32689-32691 CC denotes or
T14710 32692-32696 NN denotes mRNA
T14711 32697-32706 NN denotes stability
T14712 32706-32708 , denotes ,
T14713 32708-32713 WDT denotes which
T14714 32714-32716 VBZ denotes is
T14715 32717-32724 RB denotes exactly
T14716 32725-32729 WP denotes what
T14717 32746-32754 VBN denotes designed
T14718 32730-32733 PRP$ denotes our
T14719 32734-32741 NNS denotes methods
T14720 32742-32745 VBP denotes are
T14721 32755-32757 TO denotes to
T14722 32758-32764 VB denotes detect
T14723 32764-32765 . denotes .
T14724 32765-32965 sentence denotes A separate problem is that organ-specific gene expression differences may preclude one from detecting the relevant causative gene if the tissue arrayed is not the tissue where the control is exerted.
T14725 32766-32767 DT denotes A
T14726 32777-32784 NN denotes problem
T14727 32768-32776 JJ denotes separate
T14728 32785-32787 VBZ denotes is
T14729 32788-32792 IN denotes that
T14730 32840-32848 VB denotes preclude
T14731 32793-32798 NN denotes organ
T14732 32799-32807 JJ denotes specific
T14733 32798-32799 HYPH denotes -
T14734 32824-32835 NNS denotes differences
T14735 32808-32812 NN denotes gene
T14736 32813-32823 NN denotes expression
T14737 32836-32839 MD denotes may
T14738 32849-32852 PRP denotes one
T14739 32853-32857 IN denotes from
T14740 32858-32867 VBG denotes detecting
T14741 32868-32871 DT denotes the
T14742 32891-32895 NN denotes gene
T14743 32872-32880 JJ denotes relevant
T14744 32881-32890 JJ denotes causative
T14745 32896-32898 IN denotes if
T14746 32918-32920 VBZ denotes is
T14747 32899-32902 DT denotes the
T14748 32903-32909 NN denotes tissue
T14749 32910-32917 VBN denotes arrayed
T14750 32921-32924 RB denotes not
T14751 32925-32928 DT denotes the
T14752 32929-32935 NN denotes tissue
T14753 32936-32941 WRB denotes where
T14754 32957-32964 VBN denotes exerted
T14755 32942-32945 DT denotes the
T14756 32946-32953 NN denotes control
T14757 32954-32956 VBZ denotes is
T14758 32964-32965 . denotes .
T14759 32965-33077 sentence denotes This is particularly relevant for a trait such as adipose tissue mass, which is controlled by multiple tissues.
T14760 32966-32970 DT denotes This
T14761 32971-32973 VBZ denotes is
T14762 32974-32986 RB denotes particularly
T14763 32987-32995 JJ denotes relevant
T14764 32996-32999 IN denotes for
T14765 33000-33001 DT denotes a
T14766 33002-33007 NN denotes trait
T14767 33008-33012 JJ denotes such
T14768 33013-33015 IN denotes as
T14769 33016-33023 NN denotes adipose
T14770 33031-33035 NN denotes mass
T14771 33024-33030 NN denotes tissue
T14772 33035-33037 , denotes ,
T14773 33037-33042 WDT denotes which
T14774 33046-33056 VBN denotes controlled
T14775 33043-33045 VBZ denotes is
T14776 33057-33059 IN denotes by
T14777 33060-33068 JJ denotes multiple
T14778 33069-33076 NNS denotes tissues
T14779 33076-33077 . denotes .
T14780 33077-33163 sentence denotes We propose that analysis of correlated genes can provide guidance as discussed below.
T14781 33078-33080 PRP denotes We
T14782 33081-33088 VBP denotes propose
T14783 33089-33093 IN denotes that
T14784 33127-33134 VB denotes provide
T14785 33094-33102 NN denotes analysis
T14786 33103-33105 IN denotes of
T14787 33106-33116 VBN denotes correlated
T14788 33117-33122 NNS denotes genes
T14789 33123-33126 MD denotes can
T14790 33135-33143 NN denotes guidance
T14791 33144-33146 IN denotes as
T14792 33147-33156 VBN denotes discussed
T14793 33157-33162 RB denotes below
T14794 33162-33163 . denotes .
T15737 33165-33170 NNS denotes Genes
T15738 33204-33214 VBP denotes Illustrate
T15739 33171-33181 VBN denotes Correlated
T15740 33182-33186 IN denotes with
T15741 33187-33194 JJ denotes Gonadal
T15742 33199-33203 NN denotes Mass
T15743 33195-33198 NN denotes Fat
T15744 33215-33221 NN denotes Tissue
T15745 33222-33230 JJ denotes Specific
T15746 33221-33222 HYPH denotes -
T15747 33231-33241 NN denotes Regulation
T15748 33242-33244 IN denotes of
T15749 33245-33248 DT denotes the
T15750 33249-33254 NN denotes Trait
T15751 33254-33487 sentence denotes In an effort to identify genes associated with the fat mass trait, but not necessarily candidate genes underlying the trait cQTLs, we fitted linear models to assess the degree of association between transcripts and gonadal fat mass.
T15752 33255-33257 IN denotes In
T15753 33389-33395 VBD denotes fitted
T15754 33258-33260 DT denotes an
T15755 33261-33267 NN denotes effort
T15756 33268-33270 TO denotes to
T15757 33271-33279 VB denotes identify
T15758 33280-33285 NNS denotes genes
T15759 33286-33296 VBN denotes associated
T15760 33297-33301 IN denotes with
T15761 33302-33305 DT denotes the
T15762 33315-33320 NN denotes trait
T15763 33306-33309 NN denotes fat
T15764 33310-33314 NN denotes mass
T15765 33320-33322 , denotes ,
T15766 33322-33325 CC denotes but
T15767 33326-33329 RB denotes not
T15768 33330-33341 RB denotes necessarily
T15769 33352-33357 NNS denotes genes
T15770 33342-33351 NN denotes candidate
T15771 33358-33368 VBG denotes underlying
T15772 33369-33372 DT denotes the
T15773 33379-33384 NNS denotes cQTLs
T15774 33373-33378 NN denotes trait
T15775 33384-33386 , denotes ,
T15776 33386-33388 PRP denotes we
T15777 33396-33402 JJ denotes linear
T15778 33403-33409 NNS denotes models
T15779 33410-33412 TO denotes to
T15780 33413-33419 VB denotes assess
T15781 33420-33423 DT denotes the
T15782 33424-33430 NN denotes degree
T15783 33431-33433 IN denotes of
T15784 33434-33445 NN denotes association
T15785 33446-33453 IN denotes between
T15786 33454-33465 NNS denotes transcripts
T15787 33466-33469 CC denotes and
T15788 33470-33477 JJ denotes gonadal
T15789 33482-33486 NN denotes mass
T15790 33478-33481 NN denotes fat
T15791 33486-33487 . denotes .
T15792 33487-33541 sentence denotes As with QTLs, sex-specific correlations were modeled.
T15793 33488-33490 IN denotes As
T15794 33533-33540 VBN denotes modeled
T15795 33491-33495 IN denotes with
T15796 33496-33500 NNS denotes QTLs
T15797 33500-33502 , denotes ,
T15798 33502-33505 NN denotes sex
T15799 33506-33514 JJ denotes specific
T15800 33505-33506 HYPH denotes -
T15801 33515-33527 NNS denotes correlations
T15802 33528-33532 VBD denotes were
T15803 33540-33541 . denotes .
T15804 33541-33687 sentence denotes At an FDR of 1%, 4,613 genes were found to be significantly correlated with gonadal fat mass, of which 4,254 (98%) showed sex-biased correlation.
T15805 33542-33544 IN denotes At
T15806 33576-33581 VBN denotes found
T15807 33545-33547 DT denotes an
T15808 33548-33551 NN denotes FDR
T15809 33552-33554 IN denotes of
T15810 33555-33556 CD denotes 1
T15811 33556-33557 NN denotes %
T15812 33557-33559 , denotes ,
T15813 33559-33564 CD denotes 4,613
T15814 33565-33570 NNS denotes genes
T15815 33571-33575 VBD denotes were
T15816 33582-33584 TO denotes to
T15817 33602-33612 VBN denotes correlated
T15818 33585-33587 VB denotes be
T15819 33588-33601 RB denotes significantly
T15820 33613-33617 IN denotes with
T15821 33618-33625 JJ denotes gonadal
T15822 33630-33634 NN denotes mass
T15823 33626-33629 NN denotes fat
T15824 33634-33636 , denotes ,
T15825 33636-33638 IN denotes of
T15826 33657-33663 VBD denotes showed
T15827 33639-33644 WDT denotes which
T15828 33645-33650 CD denotes 4,254
T15829 33651-33652 -LRB- denotes (
T15830 33654-33655 NN denotes %
T15831 33652-33654 CD denotes 98
T15832 33655-33656 -RRB- denotes )
T15833 33664-33667 NN denotes sex
T15834 33668-33674 VBN denotes biased
T15835 33667-33668 HYPH denotes -
T15836 33675-33686 NN denotes correlation
T15837 33686-33687 . denotes .
T15838 33687-33861 sentence denotes As indicated in Tables 4 and 5, several genes with detectable cis-eQTLs are also significantly correlated with the trait and are even further prioritized as candidate genes.
T15839 33688-33690 IN denotes As
T15840 33691-33700 VBN denotes indicated
T15841 33783-33793 VBN denotes correlated
T15842 33701-33703 IN denotes in
T15843 33704-33710 NNS denotes Tables
T15844 33711-33712 CD denotes 4
T15845 33713-33716 CC denotes and
T15846 33717-33718 CD denotes 5
T15847 33718-33720 , denotes ,
T15848 33720-33727 JJ denotes several
T15849 33728-33733 NNS denotes genes
T15850 33734-33738 IN denotes with
T15851 33739-33749 JJ denotes detectable
T15852 33754-33759 NNS denotes eQTLs
T15853 33750-33753 NN denotes cis
T15854 33753-33754 HYPH denotes -
T15855 33760-33763 VBP denotes are
T15856 33764-33768 RB denotes also
T15857 33769-33782 RB denotes significantly
T15858 33794-33798 IN denotes with
T15859 33799-33802 DT denotes the
T15860 33803-33808 NN denotes trait
T15861 33809-33812 CC denotes and
T15862 33813-33816 VBP denotes are
T15863 33830-33841 VBN denotes prioritized
T15864 33817-33821 RB denotes even
T15865 33822-33829 RB denotes further
T15866 33842-33844 IN denotes as
T15867 33845-33854 NN denotes candidate
T15868 33855-33860 NNS denotes genes
T15869 33860-33861 . denotes .
T15870 33861-34038 sentence denotes Thus far, studies that have examined the “genetics of gene expression” are in good agreement regarding the increased power to detect cis-eQTLs relative to trans [5,9,15,16,31].
T15871 33862-33866 RB denotes Thus
T15872 33867-33870 RB denotes far
T15873 33933-33936 VBP denotes are
T15874 33870-33872 , denotes ,
T15875 33872-33879 NNS denotes studies
T15876 33880-33884 WDT denotes that
T15877 33890-33898 VBN denotes examined
T15878 33885-33889 VBP denotes have
T15879 33899-33902 DT denotes the
T15880 33904-33912 NN denotes genetics
T15881 33903-33904 `` denotes “
T15882 33913-33915 IN denotes of
T15883 33916-33920 NN denotes gene
T15884 33921-33931 NN denotes expression
T15885 33931-33932 '' denotes ”
T15886 33937-33939 IN denotes in
T15887 33940-33944 JJ denotes good
T15888 33945-33954 NN denotes agreement
T15889 33955-33964 VBG denotes regarding
T15890 33965-33968 DT denotes the
T15891 33979-33984 NN denotes power
T15892 33969-33978 VBN denotes increased
T15893 33985-33987 TO denotes to
T15894 33988-33994 VB denotes detect
T15895 33995-33998 NN denotes cis
T15896 33999-34004 NNS denotes eQTLs
T15897 33998-33999 HYPH denotes -
T15898 34005-34013 JJ denotes relative
T15899 34014-34016 IN denotes to
T15900 34017-34022 NN denotes trans
T15901 34023-34024 -LRB- denotes [
T15902 34034-34036 CD denotes 31
T15903 34024-34025 CD denotes 5
T15904 34025-34026 , denotes ,
T15905 34026-34027 CD denotes 9
T15906 34027-34028 , denotes ,
T15907 34028-34030 CD denotes 15
T15908 34030-34031 , denotes ,
T15909 34031-34033 CD denotes 16
T15910 34033-34034 , denotes ,
T15911 34036-34037 -RRB- denotes ]
T15912 34037-34038 . denotes .
T15913 34038-34192 sentence denotes It is unclear at this time, however, what exactly is the significance of trans-eQTLs and the nature of the underlying polymorphisms associated with them.
T15914 34039-34041 PRP denotes It
T15915 34042-34044 VBZ denotes is
T15916 34045-34052 JJ denotes unclear
T15917 34053-34055 IN denotes at
T15918 34056-34060 DT denotes this
T15919 34061-34065 NN denotes time
T15920 34065-34067 , denotes ,
T15921 34067-34074 RB denotes however
T15922 34074-34076 , denotes ,
T15923 34076-34080 WP denotes what
T15924 34089-34091 VBZ denotes is
T15925 34081-34088 RB denotes exactly
T15926 34092-34095 DT denotes the
T15927 34096-34108 NN denotes significance
T15928 34109-34111 IN denotes of
T15929 34112-34117 NN denotes trans
T15930 34118-34123 NNS denotes eQTLs
T15931 34117-34118 HYPH denotes -
T15932 34124-34127 CC denotes and
T15933 34128-34131 DT denotes the
T15934 34132-34138 NN denotes nature
T15935 34139-34141 IN denotes of
T15936 34142-34145 DT denotes the
T15937 34157-34170 NNS denotes polymorphisms
T15938 34146-34156 VBG denotes underlying
T15939 34171-34181 VBN denotes associated
T15940 34182-34186 IN denotes with
T15941 34187-34191 PRP denotes them
T15942 34191-34192 . denotes .
T15943 34192-34301 sentence denotes Furthermore, the eQTL hotspots reported in this and previous studies [5,9,10] largely represent trans-eQTLs.
T15944 34193-34204 RB denotes Furthermore
T15945 34279-34288 VBP denotes represent
T15946 34204-34206 , denotes ,
T15947 34206-34209 DT denotes the
T15948 34215-34223 NNS denotes hotspots
T15949 34210-34214 NN denotes eQTL
T15950 34224-34232 VBN denotes reported
T15951 34233-34235 IN denotes in
T15952 34236-34240 DT denotes this
T15953 34245-34253 JJ denotes previous
T15954 34241-34244 CC denotes and
T15955 34254-34261 NNS denotes studies
T15956 34262-34263 -LRB- denotes [
T15957 34267-34269 CD denotes 10
T15958 34263-34264 CD denotes 5
T15959 34264-34265 , denotes ,
T15960 34265-34266 CD denotes 9
T15961 34266-34267 , denotes ,
T15962 34269-34270 -RRB- denotes ]
T15963 34271-34278 RB denotes largely
T15964 34289-34294 NN denotes trans
T15965 34295-34300 NNS denotes eQTLs
T15966 34294-34295 HYPH denotes -
T15967 34300-34301 . denotes .
T15968 34301-34375 sentence denotes This localization suggests some functional significance to these regions.
T15969 34302-34306 DT denotes This
T15970 34307-34319 NN denotes localization
T15971 34320-34328 VBZ denotes suggests
T15972 34329-34333 DT denotes some
T15973 34345-34357 NN denotes significance
T15974 34334-34344 JJ denotes functional
T15975 34358-34360 IN denotes to
T15976 34361-34366 DT denotes these
T15977 34367-34374 NNS denotes regions
T15978 34374-34375 . denotes .
T15979 34375-34507 sentence denotes Of the 4,613 genes correlated with gonadal fat mass, 1,130 generate 1,478 significant eQTLs, of which 1,023 (69%) are trans-acting.
T15980 34376-34378 IN denotes Of
T15981 34435-34443 VBP denotes generate
T15982 34379-34382 DT denotes the
T15983 34389-34394 NNS denotes genes
T15984 34383-34388 CD denotes 4,613
T15985 34395-34405 VBN denotes correlated
T15986 34406-34410 IN denotes with
T15987 34411-34418 JJ denotes gonadal
T15988 34423-34427 NN denotes mass
T15989 34419-34422 NN denotes fat
T15990 34427-34429 , denotes ,
T15991 34429-34434 CD denotes 1,130
T15992 34444-34449 CD denotes 1,478
T15993 34462-34467 NNS denotes eQTLs
T15994 34450-34461 JJ denotes significant
T15995 34467-34469 , denotes ,
T15996 34469-34471 IN denotes of
T15997 34490-34493 VBP denotes are
T15998 34472-34477 WDT denotes which
T15999 34478-34483 CD denotes 1,023
T16000 34484-34485 -LRB- denotes (
T16001 34487-34488 NN denotes %
T16002 34485-34487 CD denotes 69
T16003 34488-34489 -RRB- denotes )
T16004 34494-34499 NN denotes trans
T16005 34500-34506 VBG denotes acting
T16006 34499-34500 HYPH denotes -
T16007 34506-34507 . denotes .
T16008 34507-34576 sentence denotes These eQTLs are significantly enriched at one locus (Chromosome 19).
T16009 34508-34513 DT denotes These
T16010 34514-34519 NNS denotes eQTLs
T16011 34538-34546 VBN denotes enriched
T16012 34520-34523 VBP denotes are
T16013 34524-34537 RB denotes significantly
T16014 34547-34549 IN denotes at
T16015 34550-34553 CD denotes one
T16016 34554-34559 NN denotes locus
T16017 34560-34561 -LRB- denotes (
T16018 34561-34571 NN denotes Chromosome
T16019 34572-34574 CD denotes 19
T16020 34574-34575 -RRB- denotes )
T16021 34575-34576 . denotes .
T16022 34576-34680 sentence denotes Interestingly, this hotspot was coincident with a cQTL associated with fat mass reported in this study.
T16023 34577-34590 RB denotes Interestingly
T16024 34605-34608 VBD denotes was
T16025 34590-34592 , denotes ,
T16026 34592-34596 DT denotes this
T16027 34597-34604 NN denotes hotspot
T16028 34609-34619 JJ denotes coincident
T16029 34620-34624 IN denotes with
T16030 34625-34626 DT denotes a
T16031 34627-34631 NN denotes cQTL
T16032 34632-34642 VBN denotes associated
T16033 34643-34647 IN denotes with
T16034 34648-34651 NN denotes fat
T16035 34652-34656 NN denotes mass
T16036 34657-34665 VBN denotes reported
T16037 34666-34668 IN denotes in
T16038 34669-34673 DT denotes this
T16039 34674-34679 NN denotes study
T16040 34679-34680 . denotes .
T16041 34680-34985 sentence denotes Since these transcripts represent those significantly correlated with gonadal fat mass, the localization of their eQTLs to these regions strongly supports the notion that the genes with trans-eQTLs represent downstream targets of candidate regulatory genes located at the position of significant linkage.
T16042 34681-34686 IN denotes Since
T16043 34705-34714 VBP denotes represent
T16044 34687-34692 DT denotes these
T16045 34693-34704 NNS denotes transcripts
T16046 34827-34835 VBZ denotes supports
T16047 34715-34720 DT denotes those
T16048 34721-34734 RB denotes significantly
T16049 34735-34745 VBN denotes correlated
T16050 34746-34750 IN denotes with
T16051 34751-34758 JJ denotes gonadal
T16052 34763-34767 NN denotes mass
T16053 34759-34762 NN denotes fat
T16054 34767-34769 , denotes ,
T16055 34769-34772 DT denotes the
T16056 34773-34785 NN denotes localization
T16057 34786-34788 IN denotes of
T16058 34789-34794 PRP$ denotes their
T16059 34795-34800 NNS denotes eQTLs
T16060 34801-34803 IN denotes to
T16061 34804-34809 DT denotes these
T16062 34810-34817 NNS denotes regions
T16063 34818-34826 RB denotes strongly
T16064 34836-34839 DT denotes the
T16065 34840-34846 NN denotes notion
T16066 34847-34851 IN denotes that
T16067 34879-34888 VB denotes represent
T16068 34852-34855 DT denotes the
T16069 34856-34861 NNS denotes genes
T16070 34862-34866 IN denotes with
T16071 34867-34872 NN denotes trans
T16072 34873-34878 NNS denotes eQTLs
T16073 34872-34873 HYPH denotes -
T16074 34889-34899 JJ denotes downstream
T16075 34900-34907 NNS denotes targets
T16076 34908-34910 IN denotes of
T16077 34911-34920 NN denotes candidate
T16078 34932-34937 NNS denotes genes
T16079 34921-34931 JJ denotes regulatory
T16080 34938-34945 VBN denotes located
T16081 34946-34948 IN denotes at
T16082 34949-34952 DT denotes the
T16083 34953-34961 NN denotes position
T16084 34962-34964 IN denotes of
T16085 34965-34976 JJ denotes significant
T16086 34977-34984 NN denotes linkage
T16087 34984-34985 . denotes .
T16088 34985-35171 sentence denotes This means that the genes may be causal but downstream of the gene responsible for the cQTLs, or they may be reacting to the increased gonadal fat mass and associated metabolic changes.
T16089 34986-34990 DT denotes This
T16090 34991-34996 VBZ denotes means
T16091 34997-35001 IN denotes that
T16092 35016-35018 VB denotes be
T16093 35002-35005 DT denotes the
T16094 35006-35011 NNS denotes genes
T16095 35012-35015 MD denotes may
T16096 35019-35025 JJ denotes causal
T16097 35026-35029 CC denotes but
T16098 35030-35040 RB denotes downstream
T16099 35041-35043 IN denotes of
T16100 35044-35047 DT denotes the
T16101 35048-35052 NN denotes gene
T16102 35053-35064 JJ denotes responsible
T16103 35065-35068 IN denotes for
T16104 35069-35072 DT denotes the
T16105 35073-35078 NNS denotes cQTLs
T16106 35078-35080 , denotes ,
T16107 35080-35082 CC denotes or
T16108 35083-35087 PRP denotes they
T16109 35095-35103 VBG denotes reacting
T16110 35088-35091 MD denotes may
T16111 35092-35094 VB denotes be
T16112 35104-35106 IN denotes to
T16113 35107-35110 DT denotes the
T16114 35133-35137 NN denotes mass
T16115 35111-35120 VBN denotes increased
T16116 35121-35128 JJ denotes gonadal
T16117 35129-35132 NN denotes fat
T16118 35138-35141 CC denotes and
T16119 35142-35152 VBN denotes associated
T16120 35163-35170 NNS denotes changes
T16121 35153-35162 JJ denotes metabolic
T16122 35170-35171 . denotes .
T16123 35171-35376 sentence denotes These data also suggest that identifying such loci that show overrepresentation of highly correlated genes is a means to identify which of the trait cQTLs are more likely controlled by the tissue arrayed.
T16124 35172-35177 DT denotes These
T16125 35178-35182 NNS denotes data
T16126 35188-35195 VBP denotes suggest
T16127 35183-35187 RB denotes also
T16128 35196-35200 IN denotes that
T16129 35279-35281 VBZ denotes is
T16130 35201-35212 VBG denotes identifying
T16131 35213-35217 JJ denotes such
T16132 35218-35222 NNS denotes loci
T16133 35223-35227 WDT denotes that
T16134 35228-35232 VBP denotes show
T16135 35233-35251 NN denotes overrepresentation
T16136 35252-35254 IN denotes of
T16137 35255-35261 RB denotes highly
T16138 35262-35272 VBN denotes correlated
T16139 35273-35278 NNS denotes genes
T16140 35282-35283 DT denotes a
T16141 35284-35289 NN denotes means
T16142 35290-35292 TO denotes to
T16143 35293-35301 VB denotes identify
T16144 35302-35307 WDT denotes which
T16145 35343-35353 VBN denotes controlled
T16146 35308-35310 IN denotes of
T16147 35311-35314 DT denotes the
T16148 35321-35326 NNS denotes cQTLs
T16149 35315-35320 NN denotes trait
T16150 35327-35330 VBP denotes are
T16151 35331-35335 RBR denotes more
T16152 35336-35342 RB denotes likely
T16153 35354-35356 IN denotes by
T16154 35357-35360 DT denotes the
T16155 35361-35367 NN denotes tissue
T16156 35368-35375 VBN denotes arrayed
T16157 35375-35376 . denotes .
T16158 35376-35489 sentence denotes As expected, the Chromosome 19 locus was enriched for trans-eQTLs with substantially greater effects in females.
T16159 35377-35379 IN denotes As
T16160 35380-35388 VBN denotes expected
T16161 35414-35417 VBD denotes was
T16162 35388-35390 , denotes ,
T16163 35390-35393 DT denotes the
T16164 35408-35413 NN denotes locus
T16165 35394-35404 NN denotes Chromosome
T16166 35405-35407 CD denotes 19
T16167 35418-35426 JJ denotes enriched
T16168 35427-35430 IN denotes for
T16169 35431-35436 NN denotes trans
T16170 35437-35442 NNS denotes eQTLs
T16171 35436-35437 HYPH denotes -
T16172 35443-35447 IN denotes with
T16173 35448-35461 RB denotes substantially
T16174 35462-35469 JJR denotes greater
T16175 35470-35477 NNS denotes effects
T16176 35478-35480 IN denotes in
T16177 35481-35488 NNS denotes females
T16178 35488-35489 . denotes .
T16179 35489-35580 sentence denotes Functional and promoter analysis of genes with a common trans-eQTL may prove enlightening.
T16180 35490-35500 JJ denotes Functional
T16181 35514-35522 NN denotes analysis
T16182 35501-35504 CC denotes and
T16183 35505-35513 NN denotes promoter
T16184 35561-35566 VB denotes prove
T16185 35523-35525 IN denotes of
T16186 35526-35531 NNS denotes genes
T16187 35532-35536 IN denotes with
T16188 35537-35538 DT denotes a
T16189 35552-35556 NN denotes eQTL
T16190 35539-35545 JJ denotes common
T16191 35546-35551 NN denotes trans
T16192 35551-35552 HYPH denotes -
T16193 35557-35560 MD denotes may
T16194 35567-35579 JJ denotes enlightening
T16195 35579-35580 . denotes .
T16196 35580-35740 sentence denotes Furthermore, gene expression network construction and analysis may be improved by the incorporation of experimentally demonstrated cis versus trans regulation.
T16197 35581-35592 RB denotes Furthermore
T16198 35651-35659 VBN denotes improved
T16199 35592-35594 , denotes ,
T16200 35594-35598 NN denotes gene
T16201 35599-35609 NN denotes expression
T16202 35618-35630 NN denotes construction
T16203 35610-35617 NN denotes network
T16204 35631-35634 CC denotes and
T16205 35635-35643 NN denotes analysis
T16206 35644-35647 MD denotes may
T16207 35648-35650 VB denotes be
T16208 35660-35662 IN denotes by
T16209 35663-35666 DT denotes the
T16210 35667-35680 NN denotes incorporation
T16211 35681-35683 IN denotes of
T16212 35684-35698 RB denotes experimentally
T16213 35699-35711 VBN denotes demonstrated
T16214 35729-35739 NN denotes regulation
T16215 35712-35715 NN denotes cis
T16216 35723-35728 NN denotes trans
T16217 35716-35722 IN denotes versus
T16218 35739-35740 . denotes .
T16906 35742-35752 NN denotes Conclusion
T16907 35752-35880 sentence denotes The integration of traditional genetics with genome-wide expression analysis was first proposed by Jansen and Nap 4 y ago [32].
T16908 35753-35756 DT denotes The
T16909 35757-35768 NN denotes integration
T16910 35840-35848 VBN denotes proposed
T16911 35769-35771 IN denotes of
T16912 35772-35783 JJ denotes traditional
T16913 35784-35792 NN denotes genetics
T16914 35793-35797 IN denotes with
T16915 35798-35804 NN denotes genome
T16916 35805-35809 JJ denotes wide
T16917 35804-35805 HYPH denotes -
T16918 35821-35829 NN denotes analysis
T16919 35810-35820 NN denotes expression
T16920 35830-35833 VBD denotes was
T16921 35834-35839 RB denotes first
T16922 35849-35851 IN denotes by
T16923 35852-35858 NNP denotes Jansen
T16924 35859-35862 CC denotes and
T16925 35863-35866 NNP denotes Nap
T16926 35867-35868 CD denotes 4
T16927 35869-35870 NN denotes y
T16928 35871-35874 RB denotes ago
T16929 35875-35876 -LRB- denotes [
T16930 35876-35878 CD denotes 32
T16931 35878-35879 -RRB- denotes ]
T16932 35879-35880 . denotes .
T16933 35880-36043 sentence denotes Advances in genomic technology and bioinformatic resources since then have vastly improved the applicability of these methods to the dissection of complex traits.
T16934 35881-35889 NNS denotes Advances
T16935 35963-35971 VBN denotes improved
T16936 35890-35892 IN denotes in
T16937 35893-35900 JJ denotes genomic
T16938 35901-35911 NN denotes technology
T16939 35912-35915 CC denotes and
T16940 35916-35929 JJ denotes bioinformatic
T16941 35930-35939 NNS denotes resources
T16942 35940-35945 IN denotes since
T16943 35946-35950 RB denotes then
T16944 35951-35955 VBP denotes have
T16945 35956-35962 RB denotes vastly
T16946 35972-35975 DT denotes the
T16947 35976-35989 NN denotes applicability
T16948 35990-35992 IN denotes of
T16949 35993-35998 DT denotes these
T16950 35999-36006 NNS denotes methods
T16951 36007-36009 IN denotes to
T16952 36010-36013 DT denotes the
T16953 36014-36024 NN denotes dissection
T16954 36025-36027 IN denotes of
T16955 36028-36035 JJ denotes complex
T16956 36036-36042 NNS denotes traits
T16957 36042-36043 . denotes .
T16958 36043-36219 sentence denotes Taking into account sex-specific effects will similarly improve the sensitivity to detect underlying genetic regulation, especially for phenotypes known to be affected by sex.
T16959 36044-36050 VBG denotes Taking
T16960 36100-36107 VB denotes improve
T16961 36051-36055 IN denotes into
T16962 36056-36063 NN denotes account
T16963 36064-36067 NN denotes sex
T16964 36068-36076 JJ denotes specific
T16965 36067-36068 HYPH denotes -
T16966 36077-36084 NNS denotes effects
T16967 36085-36089 MD denotes will
T16968 36090-36099 RB denotes similarly
T16969 36108-36111 DT denotes the
T16970 36112-36123 NN denotes sensitivity
T16971 36124-36126 TO denotes to
T16972 36127-36133 VB denotes detect
T16973 36134-36144 VBG denotes underlying
T16974 36153-36163 NN denotes regulation
T16975 36145-36152 JJ denotes genetic
T16976 36163-36165 , denotes ,
T16977 36165-36175 RB denotes especially
T16978 36176-36179 IN denotes for
T16979 36180-36190 NNS denotes phenotypes
T16980 36191-36196 VBN denotes known
T16981 36197-36199 TO denotes to
T16982 36203-36211 VBN denotes affected
T16983 36200-36202 VB denotes be
T16984 36212-36214 IN denotes by
T16985 36215-36218 NN denotes sex
T16986 36218-36219 . denotes .
T16987 36219-36311 sentence denotes Furthermore, network analyses are increasingly being applied to complex phenotypes [11,33].
T16988 36220-36231 RB denotes Furthermore
T16989 36273-36280 VBN denotes applied
T16990 36231-36233 , denotes ,
T16991 36233-36240 NN denotes network
T16992 36241-36249 NNS denotes analyses
T16993 36250-36253 VBP denotes are
T16994 36254-36266 RB denotes increasingly
T16995 36267-36272 VBG denotes being
T16996 36281-36283 IN denotes to
T16997 36284-36291 JJ denotes complex
T16998 36292-36302 NNS denotes phenotypes
T16999 36303-36304 -LRB- denotes [
T17000 36307-36309 CD denotes 33
T17001 36304-36306 CD denotes 11
T17002 36306-36307 , denotes ,
T17003 36309-36310 -RRB- denotes ]
T17004 36310-36311 . denotes .
T17005 36311-36648 sentence denotes Regardless of which variables are used in the construction of these networks, whether they measure gene expression or protein interactions, accounting for sex specificity, hormonal status, or construction of different networks for females and males would likely more accurately represent the complexity associated with these phenotypes.
T17006 36312-36322 RB denotes Regardless
T17007 36590-36599 VB denotes represent
T17008 36323-36325 IN denotes of
T17009 36326-36331 WDT denotes which
T17010 36332-36341 NNS denotes variables
T17011 36346-36350 VBN denotes used
T17012 36342-36345 VBP denotes are
T17013 36351-36353 IN denotes in
T17014 36354-36357 DT denotes the
T17015 36358-36370 NN denotes construction
T17016 36371-36373 IN denotes of
T17017 36374-36379 DT denotes these
T17018 36380-36388 NNS denotes networks
T17019 36388-36390 , denotes ,
T17020 36390-36397 IN denotes whether
T17021 36403-36410 VBP denotes measure
T17022 36398-36402 PRP denotes they
T17023 36411-36415 NN denotes gene
T17024 36416-36426 NN denotes expression
T17025 36427-36429 CC denotes or
T17026 36430-36437 NN denotes protein
T17027 36438-36450 NNS denotes interactions
T17028 36450-36452 , denotes ,
T17029 36452-36462 VBG denotes accounting
T17030 36463-36466 IN denotes for
T17031 36467-36470 NN denotes sex
T17032 36471-36482 NN denotes specificity
T17033 36482-36484 , denotes ,
T17034 36484-36492 JJ denotes hormonal
T17035 36493-36499 NN denotes status
T17036 36499-36501 , denotes ,
T17037 36501-36503 CC denotes or
T17038 36504-36516 NN denotes construction
T17039 36517-36519 IN denotes of
T17040 36520-36529 JJ denotes different
T17041 36530-36538 NNS denotes networks
T17042 36539-36542 IN denotes for
T17043 36543-36550 NNS denotes females
T17044 36551-36554 CC denotes and
T17045 36555-36560 NNS denotes males
T17046 36561-36566 MD denotes would
T17047 36567-36573 RB denotes likely
T17048 36574-36578 RBR denotes more
T17049 36579-36589 RB denotes accurately
T17050 36600-36603 DT denotes the
T17051 36604-36614 NN denotes complexity
T17052 36615-36625 VBN denotes associated
T17053 36626-36630 IN denotes with
T17054 36631-36636 DT denotes these
T17055 36637-36647 NNS denotes phenotypes
T17056 36647-36648 . denotes .
T17057 36648-36822 sentence denotes We reported here on the initial genetic and genomic analysis of an F2 intercross population designed to recapitulate several traits associated with human metabolic syndrome.
T17058 36649-36651 PRP denotes We
T17059 36652-36660 VBD denotes reported
T17060 36661-36665 RB denotes here
T17061 36666-36668 IN denotes on
T17062 36669-36672 DT denotes the
T17063 36701-36709 NN denotes analysis
T17064 36673-36680 JJ denotes initial
T17065 36681-36688 JJ denotes genetic
T17066 36689-36692 CC denotes and
T17067 36693-36700 JJ denotes genomic
T17068 36710-36712 IN denotes of
T17069 36713-36715 DT denotes an
T17070 36730-36740 NN denotes population
T17071 36716-36718 NN denotes F2
T17072 36719-36729 NN denotes intercross
T17073 36741-36749 VBN denotes designed
T17074 36750-36752 TO denotes to
T17075 36753-36765 VB denotes recapitulate
T17076 36766-36773 JJ denotes several
T17077 36774-36780 NNS denotes traits
T17078 36781-36791 VBN denotes associated
T17079 36792-36796 IN denotes with
T17080 36797-36802 JJ denotes human
T17081 36813-36821 NN denotes syndrome
T17082 36803-36812 JJ denotes metabolic
T17083 36821-36822 . denotes .
T17084 36822-37029 sentence denotes Using 334 mice of both sexes genotyped at high density, this is the largest study of its kind to date designed, and it is strongly powered to detect subtle effects of genetic regulation and sex specificity.
T17085 36823-36828 VBG denotes Using
T17086 36884-36886 VBZ denotes is
T17087 36829-36832 CD denotes 334
T17088 36833-36837 NNS denotes mice
T17089 36838-36840 IN denotes of
T17090 36841-36845 DT denotes both
T17091 36846-36851 NNS denotes sexes
T17092 36852-36861 VBN denotes genotyped
T17093 36862-36864 IN denotes at
T17094 36865-36869 JJ denotes high
T17095 36870-36877 NN denotes density
T17096 36877-36879 , denotes ,
T17097 36879-36883 DT denotes this
T17098 36887-36890 DT denotes the
T17099 36899-36904 NN denotes study
T17100 36891-36898 JJS denotes largest
T17101 36905-36907 IN denotes of
T17102 36908-36911 PRP$ denotes its
T17103 36912-36916 NN denotes kind
T17104 36917-36919 IN denotes to
T17105 36920-36924 NN denotes date
T17106 36925-36933 VBN denotes designed
T17107 36933-36935 , denotes ,
T17108 36935-36938 CC denotes and
T17109 36939-36941 PRP denotes it
T17110 36954-36961 VBN denotes powered
T17111 36942-36944 VBZ denotes is
T17112 36945-36953 RB denotes strongly
T17113 36962-36964 TO denotes to
T17114 36965-36971 VB denotes detect
T17115 36972-36978 JJ denotes subtle
T17116 36979-36986 NNS denotes effects
T17117 36987-36989 IN denotes of
T17118 36990-36997 JJ denotes genetic
T17119 36998-37008 NN denotes regulation
T17120 37009-37012 CC denotes and
T17121 37013-37016 NN denotes sex
T17122 37017-37028 NN denotes specificity
T17123 37028-37029 . denotes .
T17124 37029-37123 sentence denotes We identified five cQTLs for the gonadal fat mass trait, all with greater effects in females.
T17125 37030-37032 PRP denotes We
T17126 37033-37043 VBD denotes identified
T17127 37044-37048 CD denotes five
T17128 37049-37054 NNS denotes cQTLs
T17129 37055-37058 IN denotes for
T17130 37059-37062 DT denotes the
T17131 37080-37085 NN denotes trait
T17132 37063-37070 JJ denotes gonadal
T17133 37075-37079 NN denotes mass
T17134 37071-37074 NN denotes fat
T17135 37085-37087 , denotes ,
T17136 37087-37090 DT denotes all
T17137 37091-37095 IN denotes with
T17138 37096-37103 JJR denotes greater
T17139 37104-37111 NNS denotes effects
T17140 37112-37114 IN denotes in
T17141 37115-37122 NNS denotes females
T17142 37122-37123 . denotes .
T17143 37123-37333 sentence denotes We also detected several thousand significant liver eQTLs, a significant fraction of which are sex-biased, demonstrating how meaningful effects of sex on gene expression extend beyond overall mean differences.
T17144 37124-37126 PRP denotes We
T17145 37132-37140 VBD denotes detected
T17146 37127-37131 RB denotes also
T17147 37141-37148 JJ denotes several
T17148 37149-37157 CD denotes thousand
T17149 37176-37181 NNS denotes eQTLs
T17150 37158-37169 JJ denotes significant
T17151 37170-37175 NN denotes liver
T17152 37181-37183 , denotes ,
T17153 37183-37184 DT denotes a
T17154 37197-37205 NN denotes fraction
T17155 37185-37196 JJ denotes significant
T17156 37215-37218 VBP denotes are
T17157 37206-37208 IN denotes of
T17158 37209-37214 WDT denotes which
T17159 37219-37222 NN denotes sex
T17160 37223-37229 VBN denotes biased
T17161 37222-37223 HYPH denotes -
T17162 37229-37231 , denotes ,
T17163 37231-37244 VBG denotes demonstrating
T17164 37245-37248 WRB denotes how
T17165 37294-37300 VBP denotes extend
T17166 37249-37259 JJ denotes meaningful
T17167 37260-37267 NNS denotes effects
T17168 37268-37270 IN denotes of
T17169 37271-37274 NN denotes sex
T17170 37275-37277 IN denotes on
T17171 37278-37282 NN denotes gene
T17172 37283-37293 NN denotes expression
T17173 37301-37307 IN denotes beyond
T17174 37308-37315 JJ denotes overall
T17175 37321-37332 NNS denotes differences
T17176 37316-37320 NN denotes mean
T17177 37332-37333 . denotes .
T17178 37333-37429 sentence denotes We demonstrated the application of linkage and correlation methods to identify candidate genes.
T17179 37334-37336 PRP denotes We
T17180 37337-37349 VBD denotes demonstrated
T17181 37350-37353 DT denotes the
T17182 37354-37365 NN denotes application
T17183 37366-37368 IN denotes of
T17184 37369-37376 NN denotes linkage
T17185 37393-37400 NNS denotes methods
T17186 37377-37380 CC denotes and
T17187 37381-37392 NN denotes correlation
T17188 37401-37403 TO denotes to
T17189 37404-37412 VB denotes identify
T17190 37413-37422 NN denotes candidate
T17191 37423-37428 NNS denotes genes
T17192 37428-37429 . denotes .
T17193 37429-37615 sentence denotes Finally, we showed that localization of a subset of liver genes linked in trans to a cQTL region can identify relative tissue contributions to the genetic regulation of a complex trait.
T17194 37430-37437 RB denotes Finally
T17195 37442-37448 VBD denotes showed
T17196 37437-37439 , denotes ,
T17197 37439-37441 PRP denotes we
T17198 37449-37453 IN denotes that
T17199 37531-37539 VB denotes identify
T17200 37454-37466 NN denotes localization
T17201 37467-37469 IN denotes of
T17202 37470-37471 DT denotes a
T17203 37472-37478 NN denotes subset
T17204 37479-37481 IN denotes of
T17205 37482-37487 NN denotes liver
T17206 37488-37493 NNS denotes genes
T17207 37494-37500 VBN denotes linked
T17208 37501-37503 IN denotes in
T17209 37504-37509 NN denotes trans
T17210 37510-37512 IN denotes to
T17211 37513-37514 DT denotes a
T17212 37520-37526 NN denotes region
T17213 37515-37519 NN denotes cQTL
T17214 37527-37530 MD denotes can
T17215 37540-37548 JJ denotes relative
T17216 37556-37569 NNS denotes contributions
T17217 37549-37555 NN denotes tissue
T17218 37570-37572 IN denotes to
T17219 37573-37576 DT denotes the
T17220 37585-37595 NN denotes regulation
T17221 37577-37584 JJ denotes genetic
T17222 37596-37598 IN denotes of
T17223 37599-37600 DT denotes a
T17224 37609-37614 NN denotes trait
T17225 37601-37608 JJ denotes complex
T17226 37614-37615 . denotes .
T17227 37615-37780 sentence denotes We anticipate that the application of these and similar methods would significantly improve the elucidation of the genetic regulation underlying complex phenotypes.
T17228 37616-37618 PRP denotes We
T17229 37619-37629 VBP denotes anticipate
T17230 37630-37634 IN denotes that
T17231 37700-37707 VB denotes improve
T17232 37635-37638 DT denotes the
T17233 37639-37650 NN denotes application
T17234 37651-37653 IN denotes of
T17235 37654-37659 DT denotes these
T17236 37664-37671 JJ denotes similar
T17237 37660-37663 CC denotes and
T17238 37672-37679 NNS denotes methods
T17239 37680-37685 MD denotes would
T17240 37686-37699 RB denotes significantly
T17241 37708-37711 DT denotes the
T17242 37712-37723 NN denotes elucidation
T17243 37724-37726 IN denotes of
T17244 37727-37730 DT denotes the
T17245 37739-37749 NN denotes regulation
T17246 37731-37738 JJ denotes genetic
T17247 37750-37760 VBG denotes underlying
T17248 37761-37768 JJ denotes complex
T17249 37769-37779 NNS denotes phenotypes
T17250 37779-37780 . denotes .
T17616 37805-37812 NNS denotes Animals
T17617 37813-37816 CC denotes and
T17618 37817-37823 NN denotes tissue
T17619 37824-37834 NN denotes collection
T17620 37834-37835 . denotes .
T17621 37835-37940 sentence denotes C57BL/6J ApoE−/− (B6.ApoE−/−) were purchased from Jackson Laboratory (Bar Harbor, Maine, United States).
T17622 37836-37841 NN denotes C57BL
T17623 37842-37844 NN denotes 6J
T17624 37841-37842 HYPH denotes /
T17625 37845-37849 NN denotes ApoE
T17626 37871-37880 VBN denotes purchased
T17627 37849-37850 SYM denotes −
T17628 37850-37851 HYPH denotes /
T17629 37851-37852 SYM denotes −
T17630 37853-37854 -LRB- denotes (
T17631 37854-37861 NN denotes B6.ApoE
T17632 37861-37862 SYM denotes −
T17633 37862-37863 HYPH denotes /
T17634 37863-37864 SYM denotes −
T17635 37864-37865 -RRB- denotes )
T17636 37866-37870 VBD denotes were
T17637 37881-37885 IN denotes from
T17638 37886-37893 NNP denotes Jackson
T17639 37894-37904 NNP denotes Laboratory
T17640 37905-37906 -LRB- denotes (
T17641 37910-37916 NNP denotes Harbor
T17642 37906-37909 NNP denotes Bar
T17643 37916-37918 , denotes ,
T17644 37918-37923 NNP denotes Maine
T17645 37923-37925 , denotes ,
T17646 37925-37931 NNP denotes United
T17647 37932-37938 NNP denotes States
T17648 37938-37939 -RRB- denotes )
T17649 37939-37940 . denotes .
T17650 37940-38040 sentence denotes C3H/HeJ ApoE−/− (C3H.ApoE−/−) were generated by backcrossing B6.ApoE−/− to C3H for ten generations.
T17651 37941-37944 NN denotes C3H
T17652 37945-37948 NN denotes HeJ
T17653 37944-37945 HYPH denotes /
T17654 37949-37953 NN denotes ApoE
T17655 37976-37985 VBN denotes generated
T17656 37953-37954 SYM denotes −
T17657 37954-37955 HYPH denotes /
T17658 37955-37956 SYM denotes −
T17659 37957-37958 -LRB- denotes (
T17660 37958-37966 NN denotes C3H.ApoE
T17661 37966-37967 SYM denotes −
T17662 37967-37968 HYPH denotes /
T17663 37968-37969 SYM denotes −
T17664 37969-37970 -RRB- denotes )
T17665 37971-37975 VBD denotes were
T17666 37986-37988 IN denotes by
T17667 37989-38001 VBG denotes backcrossing
T17668 38002-38009 NN denotes B6.ApoE
T17669 38009-38010 SYM denotes −
T17670 38010-38011 HYPH denotes /
T17671 38011-38012 SYM denotes −
T17672 38013-38015 IN denotes to
T17673 38016-38019 NN denotes C3H
T17674 38020-38023 IN denotes for
T17675 38024-38027 CD denotes ten
T17676 38028-38039 NNS denotes generations
T17677 38039-38040 . denotes .
T17678 38040-38190 sentence denotes F1 mice were generated from reciprocal intercrossing between B6.ApoE−/− and C3H.ApoE−/−, and F2 mice were subsequently bred by intercrossing F1 mice.
T17679 38041-38043 NN denotes F1
T17680 38044-38048 NNS denotes mice
T17681 38054-38063 VBN denotes generated
T17682 38049-38053 VBD denotes were
T17683 38064-38068 IN denotes from
T17684 38069-38079 JJ denotes reciprocal
T17685 38080-38093 NN denotes intercrossing
T17686 38094-38101 IN denotes between
T17687 38102-38109 NN denotes B6.ApoE
T17688 38109-38110 SYM denotes −
T17689 38110-38111 HYPH denotes /
T17690 38111-38112 SYM denotes −
T17691 38113-38116 CC denotes and
T17692 38117-38125 NN denotes C3H.ApoE
T17693 38125-38126 SYM denotes −
T17694 38126-38127 HYPH denotes /
T17695 38127-38128 SYM denotes −
T17696 38128-38130 , denotes ,
T17697 38130-38133 CC denotes and
T17698 38134-38136 NN denotes F2
T17699 38137-38141 NNS denotes mice
T17700 38160-38164 VBN denotes bred
T17701 38142-38146 VBD denotes were
T17702 38147-38159 RB denotes subsequently
T17703 38165-38167 IN denotes by
T17704 38168-38181 VBG denotes intercrossing
T17705 38182-38184 NN denotes F1
T17706 38185-38189 NNS denotes mice
T17707 38189-38190 . denotes .
T17708 38190-38248 sentence denotes A total of 334 mice (169 female, 165 male) were produced.
T17709 38191-38192 DT denotes A
T17710 38193-38198 NN denotes total
T17711 38239-38247 VBN denotes produced
T17712 38199-38201 IN denotes of
T17713 38202-38205 CD denotes 334
T17714 38206-38210 NNS denotes mice
T17715 38211-38212 -LRB- denotes (
T17716 38212-38215 CD denotes 169
T17717 38216-38222 JJ denotes female
T17718 38222-38224 , denotes ,
T17719 38224-38227 CD denotes 165
T17720 38228-38232 JJ denotes male
T17721 38232-38233 -RRB- denotes )
T17722 38234-38238 VBD denotes were
T17723 38247-38248 . denotes .
T17724 38248-38407 sentence denotes All mice were fed Purina Chow containing 4% fat until 8 wk of age and then transferred to a “Western” diet containing 42% fat and 0.15% cholesterol for 16 wk.
T17725 38249-38252 DT denotes All
T17726 38253-38257 NNS denotes mice
T17727 38263-38266 VBN denotes fed
T17728 38258-38262 VBD denotes were
T17729 38267-38273 NNP denotes Purina
T17730 38274-38278 NNP denotes Chow
T17731 38279-38289 VBG denotes containing
T17732 38290-38291 CD denotes 4
T17733 38291-38292 NN denotes %
T17734 38293-38296 NN denotes fat
T17735 38297-38302 IN denotes until
T17736 38303-38304 CD denotes 8
T17737 38305-38307 NN denotes wk
T17738 38308-38310 IN denotes of
T17739 38311-38314 NN denotes age
T17740 38315-38318 CC denotes and
T17741 38319-38323 RB denotes then
T17742 38324-38335 VBN denotes transferred
T17743 38336-38338 IN denotes to
T17744 38339-38340 DT denotes a
T17745 38351-38355 NN denotes diet
T17746 38341-38342 `` denotes “
T17747 38342-38349 NNP denotes Western
T17748 38349-38350 '' denotes ”
T17749 38356-38366 VBG denotes containing
T17750 38367-38369 CD denotes 42
T17751 38369-38370 NN denotes %
T17752 38371-38374 NN denotes fat
T17753 38375-38378 CC denotes and
T17754 38379-38383 CD denotes 0.15
T17755 38383-38384 NN denotes %
T17756 38385-38396 NN denotes cholesterol
T17757 38397-38400 IN denotes for
T17758 38401-38403 CD denotes 16
T17759 38404-38406 NN denotes wk
T17760 38406-38407 . denotes .
T17761 38407-38445 sentence denotes Mice were sacrificed at 24 wk of age.
T17762 38408-38412 NNS denotes Mice
T17763 38418-38428 VBN denotes sacrificed
T17764 38413-38417 VBD denotes were
T17765 38429-38431 IN denotes at
T17766 38432-38434 CD denotes 24
T17767 38435-38437 NN denotes wk
T17768 38438-38440 IN denotes of
T17769 38441-38444 NN denotes age
T17770 38444-38445 . denotes .
T17771 38445-38569 sentence denotes At death, livers were immediately collected and flash-frozen in liquid N2, and gonadal fat pads were extracted and weighed.
T17772 38446-38448 IN denotes At
T17773 38480-38489 VBN denotes collected
T17774 38449-38454 NN denotes death
T17775 38454-38456 , denotes ,
T17776 38456-38462 NNS denotes livers
T17777 38463-38467 VBD denotes were
T17778 38468-38479 RB denotes immediately
T17779 38490-38493 CC denotes and
T17780 38494-38499 NN denotes flash
T17781 38500-38506 VBN denotes frozen
T17782 38499-38500 HYPH denotes -
T17783 38507-38509 IN denotes in
T17784 38510-38516 NN denotes liquid
T17785 38517-38519 NN denotes N2
T17786 38519-38521 , denotes ,
T17787 38521-38524 CC denotes and
T17788 38525-38532 JJ denotes gonadal
T17789 38537-38541 NNS denotes pads
T17790 38533-38536 NN denotes fat
T17791 38547-38556 VBN denotes extracted
T17792 38542-38546 VBD denotes were
T17793 38557-38560 CC denotes and
T17794 38561-38568 VBN denotes weighed
T17795 38568-38569 . denotes .
T18362 38571-38574 NN denotes RNA
T18363 38575-38581 NN denotes sample
T18364 38582-38593 NN denotes preparation
T18365 38593-38595 , denotes ,
T18366 38595-38605 NN denotes microarray
T18367 38606-38619 NN denotes hybridization
T18368 38619-38621 , denotes ,
T18369 38621-38624 CC denotes and
T18370 38625-38635 NN denotes expression
T18371 38636-38644 NN denotes analysis
T18372 38644-38645 . denotes .
T18373 38645-38763 sentence denotes RNA preparation and array hybridizations were performed at Rosetta Inpharmatics (Seattle, Washington, United States).
T18374 38646-38649 NN denotes RNA
T18375 38650-38661 NN denotes preparation
T18376 38692-38701 VBN denotes performed
T18377 38662-38665 CC denotes and
T18378 38666-38671 NN denotes array
T18379 38672-38686 NNS denotes hybridizations
T18380 38687-38691 VBD denotes were
T18381 38702-38704 IN denotes at
T18382 38705-38712 NNP denotes Rosetta
T18383 38713-38725 NNP denotes Inpharmatics
T18384 38726-38727 -LRB- denotes (
T18385 38727-38734 NNP denotes Seattle
T18386 38734-38736 , denotes ,
T18387 38736-38746 NNP denotes Washington
T18388 38746-38748 , denotes ,
T18389 38748-38754 NNP denotes United
T18390 38755-38761 NNP denotes States
T18391 38761-38762 -RRB- denotes )
T18392 38762-38763 . denotes .
T18393 38763-39037 sentence denotes The custom ink-jet microarrays used in this study (Agilent Technologies, previously described [21,34]) contain 2,186 control probes and 23,574 noncontrol oligonucleotides extracted from mouse UniGene clusters and combined with RefSeq sequences and RIKEN full-length clones.
T18394 38764-38767 DT denotes The
T18395 38783-38794 NNS denotes microarrays
T18396 38768-38774 NN denotes custom
T18397 38775-38778 NN denotes ink
T18398 38779-38782 NN denotes jet
T18399 38778-38779 HYPH denotes -
T18400 38867-38874 VBP denotes contain
T18401 38795-38799 VBN denotes used
T18402 38800-38802 IN denotes in
T18403 38803-38807 DT denotes this
T18404 38808-38813 NN denotes study
T18405 38814-38815 -LRB- denotes (
T18406 38848-38857 VBN denotes described
T18407 38815-38822 NNP denotes Agilent
T18408 38823-38835 NNP denotes Technologies
T18409 38835-38837 , denotes ,
T18410 38837-38847 RB denotes previously
T18411 38858-38859 -LRB- denotes [
T18412 38862-38864 CD denotes 34
T18413 38859-38861 CD denotes 21
T18414 38861-38862 , denotes ,
T18415 38864-38865 -RRB- denotes ]
T18416 38865-38866 -RRB- denotes )
T18417 38875-38880 CD denotes 2,186
T18418 38889-38895 NNS denotes probes
T18419 38881-38888 NN denotes control
T18420 38896-38899 CC denotes and
T18421 38900-38906 CD denotes 23,574
T18422 38918-38934 NNS denotes oligonucleotides
T18423 38907-38917 JJ denotes noncontrol
T18424 38935-38944 VBN denotes extracted
T18425 38945-38949 IN denotes from
T18426 38950-38955 NN denotes mouse
T18427 38964-38972 NNS denotes clusters
T18428 38956-38963 NNP denotes UniGene
T18429 38973-38976 CC denotes and
T18430 38977-38985 VBN denotes combined
T18431 38986-38990 IN denotes with
T18432 38991-38997 NNP denotes RefSeq
T18433 38998-39007 NNS denotes sequences
T18434 39008-39011 CC denotes and
T18435 39012-39017 NN denotes RIKEN
T18436 39030-39036 NNS denotes clones
T18437 39018-39022 JJ denotes full
T18438 39023-39029 NN denotes length
T18439 39022-39023 HYPH denotes -
T18440 39036-39037 . denotes .
T18441 39037-39200 sentence denotes Mouse livers were homogenized and total RNA extracted using TRIzol reagent (Invitrogen, Carlsbad, California, United States) according to manufacturer's protocol.
T18442 39038-39043 NN denotes Mouse
T18443 39044-39050 NNS denotes livers
T18444 39056-39067 VBN denotes homogenized
T18445 39051-39055 VBD denotes were
T18446 39068-39071 CC denotes and
T18447 39072-39077 JJ denotes total
T18448 39078-39081 NN denotes RNA
T18449 39082-39091 VBN denotes extracted
T18450 39092-39097 VBG denotes using
T18451 39098-39104 NN denotes TRIzol
T18452 39105-39112 NN denotes reagent
T18453 39113-39114 -LRB- denotes (
T18454 39114-39124 NNP denotes Invitrogen
T18455 39124-39126 , denotes ,
T18456 39126-39134 NNP denotes Carlsbad
T18457 39134-39136 , denotes ,
T18458 39136-39146 NNP denotes California
T18459 39146-39148 , denotes ,
T18460 39148-39154 NNP denotes United
T18461 39155-39161 NNP denotes States
T18462 39161-39162 -RRB- denotes )
T18463 39163-39172 VBG denotes according
T18464 39173-39175 IN denotes to
T18465 39176-39188 NN denotes manufacturer
T18466 39191-39199 NN denotes protocol
T18467 39188-39190 POS denotes 's
T18468 39199-39200 . denotes .
T18469 39200-39303 sentence denotes Three micrograms of total RNA was reverse transcribed and labeled with either Cy3 or Cy5 fluorochrome.
T18470 39201-39206 CD denotes Three
T18471 39207-39217 NNS denotes micrograms
T18472 39243-39254 VBN denotes transcribed
T18473 39218-39220 IN denotes of
T18474 39221-39226 JJ denotes total
T18475 39227-39230 NN denotes RNA
T18476 39231-39234 VBD denotes was
T18477 39235-39242 JJ denotes reverse
T18478 39255-39258 CC denotes and
T18479 39259-39266 VBN denotes labeled
T18480 39267-39271 IN denotes with
T18481 39272-39278 CC denotes either
T18482 39279-39282 NN denotes Cy3
T18483 39290-39302 NN denotes fluorochrome
T18484 39283-39285 CC denotes or
T18485 39286-39289 NN denotes Cy5
T18486 39302-39303 . denotes .
T18487 39303-39499 sentence denotes Purified Cy3 or Cy5 complementary RNA was hybridized to at least two microarray slides with fluor reversal for 24 h in a hybridization chamber, washed, and scanned using a laser confocal scanner.
T18488 39304-39312 VBN denotes Purified
T18489 39338-39341 NN denotes RNA
T18490 39313-39316 NN denotes Cy3
T18491 39324-39337 JJ denotes complementary
T18492 39317-39319 CC denotes or
T18493 39320-39323 NN denotes Cy5
T18494 39346-39356 VBN denotes hybridized
T18495 39342-39345 VBD denotes was
T18496 39357-39359 IN denotes to
T18497 39360-39362 RB denotes at
T18498 39369-39372 CD denotes two
T18499 39363-39368 RB denotes least
T18500 39384-39390 NNS denotes slides
T18501 39373-39383 NN denotes microarray
T18502 39391-39395 IN denotes with
T18503 39396-39401 NN denotes fluor
T18504 39402-39410 NN denotes reversal
T18505 39411-39414 IN denotes for
T18506 39415-39417 CD denotes 24
T18507 39418-39419 NN denotes h
T18508 39420-39422 IN denotes in
T18509 39423-39424 DT denotes a
T18510 39439-39446 NN denotes chamber
T18511 39425-39438 NN denotes hybridization
T18512 39446-39448 , denotes ,
T18513 39448-39454 VBN denotes washed
T18514 39460-39467 VBN denotes scanned
T18515 39454-39456 , denotes ,
T18516 39456-39459 CC denotes and
T18517 39468-39473 VBG denotes using
T18518 39474-39475 DT denotes a
T18519 39491-39498 NN denotes scanner
T18520 39476-39481 NN denotes laser
T18521 39482-39490 JJ denotes confocal
T18522 39498-39499 . denotes .
T18523 39499-39747 sentence denotes Arrays were quantified on the basis of spot intensity relative to background, adjusted for experimental variation between arrays using average intensity over multiple channels, and fitted to an error model to determine significance (type I error).
T18524 39500-39506 NNS denotes Arrays
T18525 39512-39522 VBN denotes quantified
T18526 39507-39511 VBD denotes were
T18527 39523-39525 IN denotes on
T18528 39526-39529 DT denotes the
T18529 39530-39535 NN denotes basis
T18530 39536-39538 IN denotes of
T18531 39539-39543 NN denotes spot
T18532 39544-39553 NN denotes intensity
T18533 39554-39562 JJ denotes relative
T18534 39563-39565 IN denotes to
T18535 39566-39576 NN denotes background
T18536 39576-39578 , denotes ,
T18537 39578-39586 VBN denotes adjusted
T18538 39587-39590 IN denotes for
T18539 39591-39603 JJ denotes experimental
T18540 39604-39613 NN denotes variation
T18541 39614-39621 IN denotes between
T18542 39622-39628 NNS denotes arrays
T18543 39629-39634 VBG denotes using
T18544 39635-39642 JJ denotes average
T18545 39643-39652 NN denotes intensity
T18546 39653-39657 IN denotes over
T18547 39658-39666 JJ denotes multiple
T18548 39667-39675 NNS denotes channels
T18549 39675-39677 , denotes ,
T18550 39677-39680 CC denotes and
T18551 39681-39687 VBD denotes fitted
T18552 39688-39690 IN denotes to
T18553 39691-39693 DT denotes an
T18554 39700-39705 NN denotes model
T18555 39694-39699 NN denotes error
T18556 39706-39708 TO denotes to
T18557 39709-39718 VB denotes determine
T18558 39719-39731 NN denotes significance
T18559 39732-39733 -LRB- denotes (
T18560 39740-39745 NN denotes error
T18561 39733-39737 NN denotes type
T18562 39738-39739 CD denotes I
T18563 39745-39746 -RRB- denotes )
T18564 39746-39747 . denotes .
T18565 39747-39875 sentence denotes Gene expression is reported as the mlratio relative to the pool derived from 150 mice randomly selected from the F2 population.
T18566 39748-39752 NN denotes Gene
T18567 39753-39763 NN denotes expression
T18568 39767-39775 VBN denotes reported
T18569 39764-39766 VBZ denotes is
T18570 39776-39778 IN denotes as
T18571 39779-39782 DT denotes the
T18572 39783-39790 NN denotes mlratio
T18573 39791-39799 JJ denotes relative
T18574 39800-39802 IN denotes to
T18575 39803-39806 DT denotes the
T18576 39807-39811 NN denotes pool
T18577 39812-39819 VBN denotes derived
T18578 39820-39824 IN denotes from
T18579 39825-39828 CD denotes 150
T18580 39829-39833 NNS denotes mice
T18581 39834-39842 RB denotes randomly
T18582 39843-39851 VBN denotes selected
T18583 39852-39856 IN denotes from
T18584 39857-39860 DT denotes the
T18585 39864-39874 NN denotes population
T18586 39861-39863 NN denotes F2
T18587 39874-39875 . denotes .
T18588 39875-40008 sentence denotes For subsequent analyses, mlratio data are assumed to be normally distributed, a valid assumption as previously demonstrated [21,30].
T18589 39876-39879 IN denotes For
T18590 39918-39925 VBN denotes assumed
T18591 39880-39890 JJ denotes subsequent
T18592 39891-39899 NNS denotes analyses
T18593 39899-39901 , denotes ,
T18594 39901-39908 NN denotes mlratio
T18595 39909-39913 NNS denotes data
T18596 39914-39917 VBP denotes are
T18597 39926-39928 TO denotes to
T18598 39941-39952 VBN denotes distributed
T18599 39929-39931 VB denotes be
T18600 39932-39940 RB denotes normally
T18601 39952-39954 , denotes ,
T18602 39954-39955 DT denotes a
T18603 39962-39972 NN denotes assumption
T18604 39956-39961 JJ denotes valid
T18605 39973-39975 IN denotes as
T18606 39987-39999 VBN denotes demonstrated
T18607 39976-39986 RB denotes previously
T18608 40000-40001 -LRB- denotes [
T18609 40004-40006 CD denotes 30
T18610 40001-40003 CD denotes 21
T18611 40003-40004 , denotes ,
T18612 40006-40007 -RRB- denotes ]
T18613 40007-40008 . denotes .
T18614 40008-40274 sentence denotes The error model used to assess whether a given gene is significantly differentially expressed in a single sample relative to a pool comprised of a randomly selected subset of 150 samples has been extensively described and tested in a number of publications [35,36].
T18615 40009-40012 DT denotes The
T18616 40019-40024 NN denotes model
T18617 40013-40018 NN denotes error
T18618 40217-40226 VBN denotes described
T18619 40025-40029 VBN denotes used
T18620 40030-40032 TO denotes to
T18621 40033-40039 VB denotes assess
T18622 40040-40047 IN denotes whether
T18623 40093-40102 VBN denotes expressed
T18624 40048-40049 DT denotes a
T18625 40056-40060 NN denotes gene
T18626 40050-40055 JJ denotes given
T18627 40061-40063 VBZ denotes is
T18628 40064-40077 RB denotes significantly
T18629 40078-40092 RB denotes differentially
T18630 40103-40105 IN denotes in
T18631 40106-40107 DT denotes a
T18632 40115-40121 NN denotes sample
T18633 40108-40114 JJ denotes single
T18634 40122-40130 JJ denotes relative
T18635 40131-40133 IN denotes to
T18636 40134-40135 DT denotes a
T18637 40136-40140 NN denotes pool
T18638 40141-40150 VBN denotes comprised
T18639 40151-40153 IN denotes of
T18640 40154-40155 DT denotes a
T18641 40174-40180 NN denotes subset
T18642 40156-40164 RB denotes randomly
T18643 40165-40173 VBN denotes selected
T18644 40181-40183 IN denotes of
T18645 40184-40187 CD denotes 150
T18646 40188-40195 NNS denotes samples
T18647 40196-40199 VBZ denotes has
T18648 40200-40204 VBN denotes been
T18649 40205-40216 RB denotes extensively
T18650 40227-40230 CC denotes and
T18651 40231-40237 VBN denotes tested
T18652 40238-40240 IN denotes in
T18653 40241-40242 DT denotes a
T18654 40243-40249 NN denotes number
T18655 40250-40252 IN denotes of
T18656 40253-40265 NNS denotes publications
T18657 40266-40267 -LRB- denotes [
T18658 40270-40272 CD denotes 36
T18659 40267-40269 CD denotes 35
T18660 40269-40270 , denotes ,
T18661 40272-40273 -RRB- denotes ]
T18662 40273-40274 . denotes .
T21143 40276-40286 NN denotes Genotyping
T21144 40299-40309 NNS denotes statistics
T21145 40287-40290 CC denotes and
T21146 40291-40298 NN denotes linkage
T21147 40309-40310 . denotes .
T21148 40310-40380 sentence denotes Genomic DNA was isolated from kidney by phenol-chloroform extraction.
T21149 40311-40318 JJ denotes Genomic
T21150 40319-40322 NN denotes DNA
T21151 40327-40335 VBN denotes isolated
T21152 40323-40326 VBD denotes was
T21153 40336-40340 IN denotes from
T21154 40341-40347 NN denotes kidney
T21155 40348-40350 IN denotes by
T21156 40351-40357 NN denotes phenol
T21157 40358-40368 NN denotes chloroform
T21158 40357-40358 HYPH denotes -
T21159 40369-40379 NN denotes extraction
T21160 40379-40380 . denotes .
T21161 40380-40621 sentence denotes An examination of existing databases identified over 1,300 SNPs that showed variation between the B6 and C3H strains, and a complete linkage map for all 19 autosomes was constructed using 1,032 of these SNPs at an average density of 1.5 cM.
T21162 40381-40383 DT denotes An
T21163 40384-40395 NN denotes examination
T21164 40418-40428 VBN denotes identified
T21165 40396-40398 IN denotes of
T21166 40399-40407 VBG denotes existing
T21167 40408-40417 NNS denotes databases
T21168 40429-40433 IN denotes over
T21169 40434-40439 CD denotes 1,300
T21170 40440-40444 NNS denotes SNPs
T21171 40445-40449 WDT denotes that
T21172 40450-40456 VBD denotes showed
T21173 40457-40466 NN denotes variation
T21174 40467-40474 IN denotes between
T21175 40475-40478 DT denotes the
T21176 40490-40497 NNS denotes strains
T21177 40479-40481 NN denotes B6
T21178 40482-40485 CC denotes and
T21179 40486-40489 NN denotes C3H
T21180 40497-40499 , denotes ,
T21181 40499-40502 CC denotes and
T21182 40503-40504 DT denotes a
T21183 40522-40525 NN denotes map
T21184 40505-40513 JJ denotes complete
T21185 40514-40521 NN denotes linkage
T21186 40551-40562 VBN denotes constructed
T21187 40526-40529 IN denotes for
T21188 40530-40533 DT denotes all
T21189 40537-40546 NNS denotes autosomes
T21190 40534-40536 CD denotes 19
T21191 40547-40550 VBD denotes was
T21192 40563-40568 VBG denotes using
T21193 40569-40574 CD denotes 1,032
T21194 40575-40577 IN denotes of
T21195 40578-40583 DT denotes these
T21196 40584-40588 NNS denotes SNPs
T21197 40589-40591 IN denotes at
T21198 40592-40594 DT denotes an
T21199 40603-40610 NN denotes density
T21200 40595-40602 JJ denotes average
T21201 40611-40613 IN denotes of
T21202 40614-40617 CD denotes 1.5
T21203 40618-40620 NN denotes cM
T21204 40620-40621 . denotes .
T21205 40621-40776 sentence denotes Genotyping was conducted by ParAllele (South San Francisco, California, United States) using the molecular-inversion probe (MIB) multiplex technique [37].
T21206 40622-40632 NN denotes Genotyping
T21207 40637-40646 VBN denotes conducted
T21208 40633-40636 VBD denotes was
T21209 40647-40649 IN denotes by
T21210 40650-40659 NNP denotes ParAllele
T21211 40660-40661 -LRB- denotes (
T21212 40671-40680 NNP denotes Francisco
T21213 40661-40666 NNP denotes South
T21214 40667-40670 NNP denotes San
T21215 40680-40682 , denotes ,
T21216 40682-40692 NNP denotes California
T21217 40692-40694 , denotes ,
T21218 40694-40700 NNP denotes United
T21219 40701-40707 NNP denotes States
T21220 40707-40708 -RRB- denotes )
T21221 40709-40714 VBG denotes using
T21222 40715-40718 DT denotes the
T21223 40761-40770 NN denotes technique
T21224 40719-40728 JJ denotes molecular
T21225 40729-40738 NN denotes inversion
T21226 40728-40729 HYPH denotes -
T21227 40739-40744 NN denotes probe
T21228 40745-40746 -LRB- denotes (
T21229 40746-40749 NN denotes MIB
T21230 40749-40750 -RRB- denotes )
T21231 40751-40760 NN denotes multiplex
T21232 40771-40772 -LRB- denotes [
T21233 40772-40774 CD denotes 37
T21234 40774-40775 -RRB- denotes ]
T21235 40775-40776 . denotes .
T21236 40776-40892 sentence denotes Testing for linkage of both clinical traits and gene expression (using mlratio) was conducted using a linear model.
T21237 40777-40784 VBG denotes Testing
T21238 40861-40870 VBN denotes conducted
T21239 40785-40788 IN denotes for
T21240 40789-40796 NN denotes linkage
T21241 40797-40799 IN denotes of
T21242 40800-40804 CC denotes both
T21243 40814-40820 NNS denotes traits
T21244 40805-40813 JJ denotes clinical
T21245 40821-40824 CC denotes and
T21246 40825-40829 NN denotes gene
T21247 40830-40840 NN denotes expression
T21248 40841-40842 -LRB- denotes (
T21249 40842-40847 VBG denotes using
T21250 40848-40855 NN denotes mlratio
T21251 40855-40856 -RRB- denotes )
T21252 40857-40860 VBD denotes was
T21253 40871-40876 VBG denotes using
T21254 40877-40878 DT denotes a
T21255 40886-40891 NN denotes model
T21256 40879-40885 JJ denotes linear
T21257 40891-40892 . denotes .
T21258 40892-40927 sentence denotes Consider a phenotype denoted by y.
T21259 40893-40901 VB denotes Consider
T21260 40902-40903 DT denotes a
T21261 40904-40913 NN denotes phenotype
T21262 40914-40921 VBN denotes denoted
T21263 40922-40924 IN denotes by
T21264 40925-40926 NN denotes y
T21265 40926-40927 . denotes .
T21266 40927-41042 sentence denotes The linear model that relates variation in y to QTLs and other covariates (e.g., sex) is given by the general form
T21267 40928-40931 DT denotes The
T21268 40939-40944 NN denotes model
T21269 40932-40938 JJ denotes linear
T21270 41017-41022 VBN denotes given
T21271 40945-40949 WDT denotes that
T21272 40950-40957 VBZ denotes relates
T21273 40958-40967 NN denotes variation
T21274 40968-40970 IN denotes in
T21275 40971-40972 NN denotes y
T21276 40973-40975 IN denotes to
T21277 40976-40980 NNS denotes QTLs
T21278 40981-40984 CC denotes and
T21279 40985-40990 JJ denotes other
T21280 40991-41001 NNS denotes covariates
T21281 41002-41003 -LRB- denotes (
T21282 41003-41007 FW denotes e.g.
T21283 41009-41012 NN denotes sex
T21284 41007-41009 , denotes ,
T21285 41012-41013 -RRB- denotes )
T21286 41014-41016 VBZ denotes is
T21287 41023-41025 IN denotes by
T21288 41026-41029 DT denotes the
T21289 41038-41042 NN denotes form
T21290 41030-41037 JJ denotes general
T21291 41042-41180 sentence denotes where μ is the trait mean, X′ a vector of covariates, β being the associated vector of regression coefficients, and e the residual error.
T21292 41043-41048 WRB denotes where
T21293 41051-41053 VBZ denotes is
T21294 41049-41050 NN denotes μ
T21295 41054-41057 DT denotes the
T21296 41064-41068 NN denotes mean
T21297 41058-41063 NN denotes trait
T21298 41068-41070 , denotes ,
T21299 41070-41071 NN denotes X
T21300 41075-41081 NN denotes vector
T21301 41071-41072 SYM denotes ′
T21302 41073-41074 DT denotes a
T21303 41082-41084 IN denotes of
T21304 41085-41095 NNS denotes covariates
T21305 41095-41097 , denotes ,
T21306 41097-41098 NN denotes β
T21307 41099-41104 VBG denotes being
T21308 41105-41108 DT denotes the
T21309 41120-41126 NN denotes vector
T21310 41109-41119 VBN denotes associated
T21311 41127-41129 IN denotes of
T21312 41130-41140 NN denotes regression
T21313 41141-41153 NNS denotes coefficients
T21314 41153-41155 , denotes ,
T21315 41155-41158 CC denotes and
T21316 41159-41160 NN denotes e
T21317 41174-41179 NN denotes error
T21318 41161-41164 DT denotes the
T21319 41165-41173 JJ denotes residual
T21320 41179-41180 . denotes .
T21321 41180-41266 sentence denotes Linkage was computed for over 20 clinical traits as well as 23,574 liver transcripts.
T21322 41181-41188 NN denotes Linkage
T21323 41193-41201 VBN denotes computed
T21324 41189-41192 VBD denotes was
T21325 41202-41205 IN denotes for
T21326 41206-41210 IN denotes over
T21327 41211-41213 CD denotes 20
T21328 41223-41229 NNS denotes traits
T21329 41214-41222 JJ denotes clinical
T21330 41230-41232 RB denotes as
T21331 41238-41240 IN denotes as
T21332 41233-41237 RB denotes well
T21333 41241-41247 CD denotes 23,574
T21334 41254-41265 NNS denotes transcripts
T21335 41248-41253 NN denotes liver
T21336 41265-41266 . denotes .
T21337 41266-41336 sentence denotes Standard genome scans calculate linkage by comparing the linear model
T21338 41267-41275 JJ denotes Standard
T21339 41283-41288 NNS denotes scans
T21340 41276-41282 NN denotes genome
T21341 41289-41298 VBP denotes calculate
T21342 41299-41306 NN denotes linkage
T21343 41307-41309 IN denotes by
T21344 41310-41319 VBG denotes comparing
T21345 41320-41323 DT denotes the
T21346 41331-41336 NN denotes model
T21347 41324-41330 JJ denotes linear
T21348 41336-41354 sentence denotes to the null model
T21349 41337-41339 IN denotes to
T21350 41340-41343 DT denotes the
T21351 41349-41354 NN denotes model
T21352 41344-41348 JJ denotes null
T21353 41354-41457 sentence denotes where β1 and β2 are the regression coefficients of the additive and dominant parameters, respectively.
T21354 41355-41360 WRB denotes where
T21355 41371-41374 VBP denotes are
T21356 41361-41363 NN denotes β1
T21357 41364-41367 CC denotes and
T21358 41368-41370 NN denotes β2
T21359 41375-41378 DT denotes the
T21360 41390-41402 NNS denotes coefficients
T21361 41379-41389 NN denotes regression
T21362 41403-41405 IN denotes of
T21363 41406-41409 DT denotes the
T21364 41432-41442 NNS denotes parameters
T21365 41410-41418 JJ denotes additive
T21366 41419-41422 CC denotes and
T21367 41423-41431 JJ denotes dominant
T21368 41442-41444 , denotes ,
T21369 41444-41456 RB denotes respectively
T21370 41456-41457 . denotes .
T21371 41457-41693 sentence denotes The LOD score represents the difference in the log10 of the likelihood of the above two equations, where the individual model likelihoods are maximized with respect to the model parameters, given the marker genotype and phenotype data.
T21372 41458-41461 DT denotes The
T21373 41466-41471 NN denotes score
T21374 41462-41465 NN denotes LOD
T21375 41472-41482 VBZ denotes represents
T21376 41483-41486 DT denotes the
T21377 41487-41497 NN denotes difference
T21378 41498-41500 IN denotes in
T21379 41501-41504 DT denotes the
T21380 41505-41510 NN denotes log10
T21381 41511-41513 IN denotes of
T21382 41514-41517 DT denotes the
T21383 41518-41528 NN denotes likelihood
T21384 41529-41531 IN denotes of
T21385 41532-41535 DT denotes the
T21386 41546-41555 NNS denotes equations
T21387 41536-41541 JJ denotes above
T21388 41542-41545 CD denotes two
T21389 41555-41557 , denotes ,
T21390 41557-41562 WRB denotes where
T21391 41600-41609 VBN denotes maximized
T21392 41563-41566 DT denotes the
T21393 41584-41595 NNS denotes likelihoods
T21394 41567-41577 JJ denotes individual
T21395 41578-41583 NN denotes model
T21396 41596-41599 VBP denotes are
T21397 41610-41614 IN denotes with
T21398 41615-41622 NN denotes respect
T21399 41623-41625 IN denotes to
T21400 41626-41629 DT denotes the
T21401 41636-41646 NNS denotes parameters
T21402 41630-41635 NN denotes model
T21403 41646-41648 , denotes ,
T21404 41648-41653 VBN denotes given
T21405 41654-41657 DT denotes the
T21406 41688-41692 NNS denotes data
T21407 41658-41664 NN denotes marker
T21408 41665-41673 NN denotes genotype
T21409 41674-41677 CC denotes and
T21410 41678-41687 NN denotes phenotype
T21411 41692-41693 . denotes .
T21412 41693-41926 sentence denotes If a trait y differs on average between the two sexes but the QTL has the same effect in both males and females, we can model this interaction by including sex as an additive covariate in the above models, resulting in the new model
T21413 41694-41696 IN denotes If
T21414 41707-41714 VBZ denotes differs
T21415 41697-41698 DT denotes a
T21416 41705-41706 NN denotes y
T21417 41699-41704 NN denotes trait
T21418 41814-41819 VB denotes model
T21419 41715-41717 IN denotes on
T21420 41718-41725 JJ denotes average
T21421 41726-41733 IN denotes between
T21422 41734-41737 DT denotes the
T21423 41742-41747 NNS denotes sexes
T21424 41738-41741 CD denotes two
T21425 41748-41751 CC denotes but
T21426 41752-41755 DT denotes the
T21427 41756-41759 NNP denotes QTL
T21428 41760-41763 VBZ denotes has
T21429 41764-41767 DT denotes the
T21430 41773-41779 NN denotes effect
T21431 41768-41772 JJ denotes same
T21432 41780-41782 IN denotes in
T21433 41783-41787 CC denotes both
T21434 41788-41793 NNS denotes males
T21435 41794-41797 CC denotes and
T21436 41798-41805 NNS denotes females
T21437 41805-41807 , denotes ,
T21438 41807-41809 PRP denotes we
T21439 41810-41813 MD denotes can
T21440 41820-41824 DT denotes this
T21441 41825-41836 NN denotes interaction
T21442 41837-41839 IN denotes by
T21443 41840-41849 VBG denotes including
T21444 41850-41853 NN denotes sex
T21445 41854-41856 IN denotes as
T21446 41857-41859 DT denotes an
T21447 41869-41878 NN denotes covariate
T21448 41860-41868 JJ denotes additive
T21449 41879-41881 IN denotes in
T21450 41882-41885 DT denotes the
T21451 41892-41898 NNS denotes models
T21452 41886-41891 JJ denotes above
T21453 41898-41900 , denotes ,
T21454 41900-41909 VBG denotes resulting
T21455 41910-41912 IN denotes in
T21456 41913-41916 DT denotes the
T21457 41921-41926 NN denotes model
T21458 41917-41920 JJ denotes new
T21459 41926-41967 sentence denotes which is then compared to the null model
T21460 41927-41932 WDT denotes which
T21461 41941-41949 VBN denotes compared
T21462 41933-41935 VBZ denotes is
T21463 41936-41940 RB denotes then
T21464 41950-41952 IN denotes to
T21465 41953-41956 DT denotes the
T21466 41962-41967 NN denotes model
T21467 41957-41961 JJ denotes null
T21468 41967-42028 sentence denotes where β3 is the regression coefficient of the sex parameter.
T21469 41968-41973 WRB denotes where
T21470 41977-41979 VBZ denotes is
T21471 41974-41976 NN denotes β3
T21472 41980-41983 DT denotes the
T21473 41995-42006 NN denotes coefficient
T21474 41984-41994 NN denotes regression
T21475 42007-42009 IN denotes of
T21476 42010-42013 DT denotes the
T21477 42018-42027 NN denotes parameter
T21478 42014-42017 NN denotes sex
T21479 42027-42028 . denotes .
T21480 42028-42201 sentence denotes The effect of a QTL may be dependent on the state of a covariate; for instance, a QTL may have an effect specific to one sex, or may have opposite effects in the two sexes.
T21481 42029-42032 DT denotes The
T21482 42033-42039 NN denotes effect
T21483 42053-42055 VB denotes be
T21484 42040-42042 IN denotes of
T21485 42043-42044 DT denotes a
T21486 42045-42048 NN denotes QTL
T21487 42049-42052 MD denotes may
T21488 42119-42123 VB denotes have
T21489 42056-42065 JJ denotes dependent
T21490 42066-42068 IN denotes on
T21491 42069-42072 DT denotes the
T21492 42073-42078 NN denotes state
T21493 42079-42081 IN denotes of
T21494 42082-42083 DT denotes a
T21495 42084-42093 NN denotes covariate
T21496 42093-42094 : denotes ;
T21497 42095-42098 IN denotes for
T21498 42099-42107 NN denotes instance
T21499 42107-42109 , denotes ,
T21500 42109-42110 DT denotes a
T21501 42111-42114 NN denotes QTL
T21502 42115-42118 MD denotes may
T21503 42124-42126 DT denotes an
T21504 42127-42133 NN denotes effect
T21505 42134-42142 JJ denotes specific
T21506 42143-42145 IN denotes to
T21507 42146-42149 CD denotes one
T21508 42150-42153 NN denotes sex
T21509 42153-42155 , denotes ,
T21510 42155-42157 CC denotes or
T21511 42158-42161 MD denotes may
T21512 42162-42166 VB denotes have
T21513 42167-42175 JJ denotes opposite
T21514 42176-42183 NNS denotes effects
T21515 42184-42186 IN denotes in
T21516 42187-42190 DT denotes the
T21517 42195-42200 NNS denotes sexes
T21518 42191-42194 CD denotes two
T21519 42200-42201 . denotes .
T21520 42201-42345 sentence denotes This interaction can be modeled using a full model, which accounts for all additive covariates, as well as interactions between the covariates:
T21521 42202-42206 DT denotes This
T21522 42207-42218 NN denotes interaction
T21523 42226-42233 VBN denotes modeled
T21524 42219-42222 MD denotes can
T21525 42223-42225 VB denotes be
T21526 42234-42239 VBG denotes using
T21527 42240-42241 DT denotes a
T21528 42247-42252 NN denotes model
T21529 42242-42246 JJ denotes full
T21530 42252-42254 , denotes ,
T21531 42254-42259 WDT denotes which
T21532 42260-42268 VBZ denotes accounts
T21533 42269-42272 IN denotes for
T21534 42273-42276 DT denotes all
T21535 42286-42296 NNS denotes covariates
T21536 42277-42285 JJ denotes additive
T21537 42296-42298 , denotes ,
T21538 42298-42300 RB denotes as
T21539 42306-42308 IN denotes as
T21540 42301-42305 RB denotes well
T21541 42309-42321 NNS denotes interactions
T21542 42322-42329 IN denotes between
T21543 42330-42333 DT denotes the
T21544 42334-42344 NNS denotes covariates
T21545 42344-42345 : denotes :
T21546 42345-42401 sentence denotes which is compared to the above null model (Equation 5).
T21547 42346-42351 WDT denotes which
T21548 42355-42363 VBN denotes compared
T21549 42352-42354 VBZ denotes is
T21550 42364-42366 IN denotes to
T21551 42367-42370 DT denotes the
T21552 42382-42387 NN denotes model
T21553 42371-42376 JJ denotes above
T21554 42377-42381 JJ denotes null
T21555 42388-42389 -LRB- denotes (
T21556 42389-42397 NN denotes Equation
T21557 42398-42399 CD denotes 5
T21558 42399-42400 -RRB- denotes )
T21559 42400-42401 . denotes .
T21560 42401-42672 sentence denotes The full model (Equation 6) allows us to model all heritable and sex-specific interactions in a single equation and maximally powers us to detect significant QTLs when the sex and sex-interaction terms are significant, given all 334 animals are included in the analysis.
T21561 42402-42405 DT denotes The
T21562 42411-42416 NN denotes model
T21563 42406-42410 JJ denotes full
T21564 42430-42436 VBZ denotes allows
T21565 42417-42418 -LRB- denotes (
T21566 42418-42426 NN denotes Equation
T21567 42427-42428 CD denotes 6
T21568 42428-42429 -RRB- denotes )
T21569 42437-42439 PRP denotes us
T21570 42443-42448 VB denotes model
T21571 42440-42442 TO denotes to
T21572 42449-42452 DT denotes all
T21573 42480-42492 NNS denotes interactions
T21574 42453-42462 JJ denotes heritable
T21575 42463-42466 CC denotes and
T21576 42467-42470 JJ denotes sex
T21577 42471-42479 JJ denotes specific
T21578 42470-42471 HYPH denotes -
T21579 42493-42495 IN denotes in
T21580 42496-42497 DT denotes a
T21581 42505-42513 NN denotes equation
T21582 42498-42504 JJ denotes single
T21583 42514-42517 CC denotes and
T21584 42518-42527 RB denotes maximally
T21585 42528-42534 VBZ denotes powers
T21586 42535-42537 PRP denotes us
T21587 42541-42547 VB denotes detect
T21588 42538-42540 TO denotes to
T21589 42548-42559 JJ denotes significant
T21590 42560-42564 NNS denotes QTLs
T21591 42565-42569 WRB denotes when
T21592 42604-42607 VBP denotes are
T21593 42570-42573 DT denotes the
T21594 42598-42603 NNS denotes terms
T21595 42574-42577 NN denotes sex
T21596 42578-42581 CC denotes and
T21597 42582-42585 NN denotes sex
T21598 42586-42597 NN denotes interaction
T21599 42585-42586 HYPH denotes -
T21600 42608-42619 JJ denotes significant
T21601 42619-42621 , denotes ,
T21602 42621-42626 VBN denotes given
T21603 42627-42630 DT denotes all
T21604 42635-42642 NNS denotes animals
T21605 42631-42634 CD denotes 334
T21606 42647-42655 VBN denotes included
T21607 42643-42646 VBP denotes are
T21608 42656-42658 IN denotes in
T21609 42659-42662 DT denotes the
T21610 42663-42671 NN denotes analysis
T21611 42671-42672 . denotes .
T21612 42672-42898 sentence denotes Furthermore, using the full model obviates the need for modeling QTLs in one sex only, a procedure that could decrease our power by halving the sample size, rendering it impossible to detect interactions between QTLs and sex.
T21613 42673-42684 RB denotes Furthermore
T21614 42707-42715 VBZ denotes obviates
T21615 42684-42686 , denotes ,
T21616 42686-42691 VBG denotes using
T21617 42692-42695 DT denotes the
T21618 42701-42706 NN denotes model
T21619 42696-42700 JJ denotes full
T21620 42716-42719 DT denotes the
T21621 42720-42724 NN denotes need
T21622 42725-42728 IN denotes for
T21623 42729-42737 NN denotes modeling
T21624 42738-42742 NNS denotes QTLs
T21625 42743-42745 IN denotes in
T21626 42746-42749 CD denotes one
T21627 42750-42753 NN denotes sex
T21628 42754-42758 RB denotes only
T21629 42758-42760 , denotes ,
T21630 42760-42761 DT denotes a
T21631 42762-42771 NN denotes procedure
T21632 42772-42776 WDT denotes that
T21633 42783-42791 VB denotes decrease
T21634 42777-42782 MD denotes could
T21635 42792-42795 PRP$ denotes our
T21636 42796-42801 NN denotes power
T21637 42802-42804 IN denotes by
T21638 42805-42812 VBG denotes halving
T21639 42813-42816 DT denotes the
T21640 42824-42828 NN denotes size
T21641 42817-42823 NN denotes sample
T21642 42828-42830 , denotes ,
T21643 42830-42839 VBG denotes rendering
T21644 42840-42842 PRP denotes it
T21645 42843-42853 JJ denotes impossible
T21646 42854-42856 TO denotes to
T21647 42857-42863 VB denotes detect
T21648 42864-42876 NNS denotes interactions
T21649 42877-42884 IN denotes between
T21650 42885-42889 NNS denotes QTLs
T21651 42890-42893 CC denotes and
T21652 42894-42897 NN denotes sex
T21653 42897-42898 . denotes .
T21654 42898-43336 sentence denotes However, because the full model contains two more parameters than the model that treats sex as an additive covariate (Equation 4), the LOD score threshold for significant linkage is higher (using the convention of Lander and Kruglyak [20]), with QTL-specific significance levels of 2 × 10−3 and 5 × 10−5 equivalent to LOD scores of 4.0 (suggestive linkage) and 5.4 (significant linkage, equivalent to genome-wide p < 0.05), respectively.
T21655 42899-42906 RB denotes However
T21656 43078-43080 VBZ denotes is
T21657 42906-42908 , denotes ,
T21658 42908-42915 IN denotes because
T21659 42931-42939 VBZ denotes contains
T21660 42916-42919 DT denotes the
T21661 42925-42930 NN denotes model
T21662 42920-42924 JJ denotes full
T21663 42940-42943 CD denotes two
T21664 42949-42959 NNS denotes parameters
T21665 42944-42948 JJR denotes more
T21666 42960-42964 IN denotes than
T21667 42965-42968 DT denotes the
T21668 42969-42974 NN denotes model
T21669 42975-42979 WDT denotes that
T21670 42980-42986 VBZ denotes treats
T21671 42987-42990 NN denotes sex
T21672 42991-42993 IN denotes as
T21673 42994-42996 DT denotes an
T21674 43006-43015 NN denotes covariate
T21675 42997-43005 JJ denotes additive
T21676 43016-43017 -LRB- denotes (
T21677 43017-43025 NN denotes Equation
T21678 43026-43027 CD denotes 4
T21679 43027-43028 -RRB- denotes )
T21680 43028-43030 , denotes ,
T21681 43030-43033 DT denotes the
T21682 43044-43053 NN denotes threshold
T21683 43034-43037 NN denotes LOD
T21684 43038-43043 NN denotes score
T21685 43054-43057 IN denotes for
T21686 43058-43069 JJ denotes significant
T21687 43070-43077 NN denotes linkage
T21688 43081-43087 JJR denotes higher
T21689 43088-43089 -LRB- denotes (
T21690 43089-43094 VBG denotes using
T21691 43095-43098 DT denotes the
T21692 43099-43109 NN denotes convention
T21693 43110-43112 IN denotes of
T21694 43113-43119 NNP denotes Lander
T21695 43120-43123 CC denotes and
T21696 43124-43132 NNP denotes Kruglyak
T21697 43133-43134 -LRB- denotes [
T21698 43134-43136 CD denotes 20
T21699 43136-43137 -RRB- denotes ]
T21700 43137-43138 -RRB- denotes )
T21701 43138-43140 , denotes ,
T21702 43140-43144 IN denotes with
T21703 43145-43148 JJ denotes QTL
T21704 43149-43157 JJ denotes specific
T21705 43148-43149 HYPH denotes -
T21706 43171-43177 NNS denotes levels
T21707 43158-43170 NN denotes significance
T21708 43178-43180 IN denotes of
T21709 43181-43182 CD denotes 2
T21710 43185-43189 CD denotes 10−3
T21711 43183-43184 SYM denotes ×
T21712 43190-43193 CC denotes and
T21713 43194-43195 CD denotes 5
T21714 43198-43202 CD denotes 10−5
T21715 43196-43197 SYM denotes ×
T21716 43203-43213 JJ denotes equivalent
T21717 43214-43216 IN denotes to
T21718 43217-43220 NN denotes LOD
T21719 43221-43227 NNS denotes scores
T21720 43228-43230 IN denotes of
T21721 43231-43234 CD denotes 4.0
T21722 43235-43236 -LRB- denotes (
T21723 43247-43254 NN denotes linkage
T21724 43236-43246 JJ denotes suggestive
T21725 43254-43255 -RRB- denotes )
T21726 43256-43259 CC denotes and
T21727 43260-43263 CD denotes 5.4
T21728 43264-43265 -LRB- denotes (
T21729 43277-43284 NN denotes linkage
T21730 43265-43276 JJ denotes significant
T21731 43284-43286 , denotes ,
T21732 43286-43296 JJ denotes equivalent
T21733 43297-43299 IN denotes to
T21734 43300-43306 NN denotes genome
T21735 43307-43311 JJ denotes wide
T21736 43306-43307 HYPH denotes -
T21737 43312-43313 NN denotes p
T21738 43314-43315 SYM denotes <
T21739 43316-43320 CD denotes 0.05
T21740 43320-43321 -RRB- denotes )
T21741 43321-43323 , denotes ,
T21742 43323-43335 RB denotes respectively
T21743 43335-43336 . denotes .
T21744 43336-43481 sentence denotes As a result, if there are no significant sex-additive or sex-dominant interactions, the full model will actually reduce power to detect linkage.
T21745 43337-43339 IN denotes As
T21746 43450-43456 VB denotes reduce
T21747 43340-43341 DT denotes a
T21748 43342-43348 NN denotes result
T21749 43348-43350 , denotes ,
T21750 43350-43352 IN denotes if
T21751 43359-43362 VBP denotes are
T21752 43353-43358 EX denotes there
T21753 43363-43365 DT denotes no
T21754 43407-43419 NNS denotes interactions
T21755 43366-43377 JJ denotes significant
T21756 43378-43381 JJ denotes sex
T21757 43382-43390 JJ denotes additive
T21758 43381-43382 HYPH denotes -
T21759 43391-43393 CC denotes or
T21760 43394-43397 JJ denotes sex
T21761 43398-43406 JJ denotes dominant
T21762 43397-43398 HYPH denotes -
T21763 43419-43421 , denotes ,
T21764 43421-43424 DT denotes the
T21765 43430-43435 NN denotes model
T21766 43425-43429 JJ denotes full
T21767 43436-43440 MD denotes will
T21768 43441-43449 RB denotes actually
T21769 43457-43462 NN denotes power
T21770 43463-43465 TO denotes to
T21771 43466-43472 VB denotes detect
T21772 43473-43480 NN denotes linkage
T21773 43480-43481 . denotes .
T21774 43481-43724 sentence denotes To minimize the loss in power of fitting the full model when the sex-interaction terms are not significant, we employed a model selection procedure that introduces sex-interaction terms only if they add significantly to the overall QTL model.
T21775 43482-43484 TO denotes To
T21776 43485-43493 VB denotes minimize
T21777 43593-43601 VBD denotes employed
T21778 43494-43497 DT denotes the
T21779 43498-43502 NN denotes loss
T21780 43503-43505 IN denotes in
T21781 43506-43511 NN denotes power
T21782 43512-43514 IN denotes of
T21783 43515-43522 VBG denotes fitting
T21784 43523-43526 DT denotes the
T21785 43532-43537 NN denotes model
T21786 43527-43531 JJ denotes full
T21787 43538-43542 WRB denotes when
T21788 43569-43572 VBP denotes are
T21789 43543-43546 DT denotes the
T21790 43563-43568 NNS denotes terms
T21791 43547-43550 NN denotes sex
T21792 43551-43562 NN denotes interaction
T21793 43550-43551 HYPH denotes -
T21794 43573-43576 RB denotes not
T21795 43577-43588 JJ denotes significant
T21796 43588-43590 , denotes ,
T21797 43590-43592 PRP denotes we
T21798 43602-43603 DT denotes a
T21799 43620-43629 NN denotes procedure
T21800 43604-43609 NN denotes model
T21801 43610-43619 NN denotes selection
T21802 43630-43634 WDT denotes that
T21803 43635-43645 VBZ denotes introduces
T21804 43646-43649 NN denotes sex
T21805 43650-43661 NN denotes interaction
T21806 43649-43650 HYPH denotes -
T21807 43662-43667 NNS denotes terms
T21808 43668-43672 RB denotes only
T21809 43681-43684 VBP denotes add
T21810 43673-43675 IN denotes if
T21811 43676-43680 PRP denotes they
T21812 43685-43698 RB denotes significantly
T21813 43699-43701 IN denotes to
T21814 43702-43705 DT denotes the
T21815 43718-43723 NN denotes model
T21816 43706-43713 JJ denotes overall
T21817 43714-43717 NN denotes QTL
T21818 43723-43724 . denotes .
T21819 43724-43950 sentence denotes The model selection procedure makes use of forward stepwise regression techniques to determine whether it is beneficial to include the sex-interaction terms, conditional on realizing a significant additive effect (p < 0.001).
T21820 43725-43728 DT denotes The
T21821 43745-43754 NN denotes procedure
T21822 43729-43734 NN denotes model
T21823 43735-43744 NN denotes selection
T21824 43755-43760 VBZ denotes makes
T21825 43761-43764 NN denotes use
T21826 43765-43767 IN denotes of
T21827 43768-43775 JJ denotes forward
T21828 43785-43795 NN denotes regression
T21829 43776-43784 JJ denotes stepwise
T21830 43796-43806 NNS denotes techniques
T21831 43807-43809 TO denotes to
T21832 43810-43819 VB denotes determine
T21833 43820-43827 IN denotes whether
T21834 43831-43833 VBZ denotes is
T21835 43828-43830 PRP denotes it
T21836 43834-43844 JJ denotes beneficial
T21837 43845-43847 TO denotes to
T21838 43848-43855 VB denotes include
T21839 43856-43859 DT denotes the
T21840 43876-43881 NNS denotes terms
T21841 43860-43863 NN denotes sex
T21842 43864-43875 NN denotes interaction
T21843 43863-43864 HYPH denotes -
T21844 43881-43883 , denotes ,
T21845 43883-43894 JJ denotes conditional
T21846 43895-43897 IN denotes on
T21847 43898-43907 VBG denotes realizing
T21848 43908-43909 DT denotes a
T21849 43931-43937 NN denotes effect
T21850 43910-43921 JJ denotes significant
T21851 43922-43930 JJ denotes additive
T21852 43938-43939 -LRB- denotes (
T21853 43943-43948 CD denotes 0.001
T21854 43939-43940 NN denotes p
T21855 43941-43942 SYM denotes <
T21856 43948-43949 -RRB- denotes )
T21857 43949-43950 . denotes .
T21858 43950-44137 sentence denotes That is, the data are fitted to Equation 4 for a given marker, and if the add term is significant at the 0.001 significance level, then we attempt to add the sex*add term into the model.
T21859 43951-43955 RB denotes That
T21860 43956-43958 RB denotes is
T21861 43973-43979 VBN denotes fitted
T21862 43958-43960 , denotes ,
T21863 43960-43963 DT denotes the
T21864 43964-43968 NNS denotes data
T21865 43969-43972 VBP denotes are
T21866 43980-43982 IN denotes to
T21867 43983-43991 NN denotes Equation
T21868 43992-43993 CD denotes 4
T21869 43994-43997 IN denotes for
T21870 43998-43999 DT denotes a
T21871 44006-44012 NN denotes marker
T21872 44000-44005 JJ denotes given
T21873 44012-44014 , denotes ,
T21874 44014-44017 CC denotes and
T21875 44018-44020 IN denotes if
T21876 44034-44036 VBZ denotes is
T21877 44021-44024 DT denotes the
T21878 44029-44033 NN denotes term
T21879 44025-44028 NN denotes add
T21880 44090-44097 VBP denotes attempt
T21881 44037-44048 JJ denotes significant
T21882 44049-44051 IN denotes at
T21883 44052-44055 DT denotes the
T21884 44075-44080 NN denotes level
T21885 44056-44061 CD denotes 0.001
T21886 44062-44074 NN denotes significance
T21887 44080-44082 , denotes ,
T21888 44082-44086 RB denotes then
T21889 44087-44089 PRP denotes we
T21890 44098-44100 TO denotes to
T21891 44101-44104 VB denotes add
T21892 44105-44108 DT denotes the
T21893 44117-44121 NN denotes term
T21894 44109-44116 NN denotes sex*add
T21895 44122-44126 IN denotes into
T21896 44127-44130 DT denotes the
T21897 44131-44136 NN denotes model
T21898 44136-44137 . denotes .
T21899 44137-44278 sentence denotes The sex*add term is retained in the model if the Bayesian information criterion (BIC) for this model is smaller than the BIC for Equation 4.
T21900 44138-44141 DT denotes The
T21901 44150-44154 NN denotes term
T21902 44142-44149 NN denotes sex*add
T21903 44158-44166 VBN denotes retained
T21904 44155-44157 VBZ denotes is
T21905 44167-44169 IN denotes in
T21906 44170-44173 DT denotes the
T21907 44174-44179 NN denotes model
T21908 44180-44182 IN denotes if
T21909 44239-44241 VBZ denotes is
T21910 44183-44186 DT denotes the
T21911 44208-44217 NN denotes criterion
T21912 44187-44195 JJ denotes Bayesian
T21913 44196-44207 NN denotes information
T21914 44218-44219 -LRB- denotes (
T21915 44219-44222 NN denotes BIC
T21916 44222-44223 -RRB- denotes )
T21917 44224-44227 IN denotes for
T21918 44228-44232 DT denotes this
T21919 44233-44238 NN denotes model
T21920 44242-44249 JJR denotes smaller
T21921 44250-44254 IN denotes than
T21922 44255-44258 DT denotes the
T21923 44259-44262 NN denotes BIC
T21924 44263-44266 IN denotes for
T21925 44267-44275 NN denotes Equation
T21926 44276-44277 CD denotes 4
T21927 44277-44278 . denotes .
T21928 44278-44420 sentence denotes If sex*add is included in the model as a result of this procedure, then we again use BIC to consider including the sex*dom term in the model.
T21929 44279-44281 IN denotes If
T21930 44293-44301 VBN denotes included
T21931 44282-44289 NN denotes sex*add
T21932 44290-44292 VBZ denotes is
T21933 44360-44363 VBP denotes use
T21934 44302-44304 IN denotes in
T21935 44305-44308 DT denotes the
T21936 44309-44314 NN denotes model
T21937 44315-44317 IN denotes as
T21938 44318-44319 DT denotes a
T21939 44320-44326 NN denotes result
T21940 44327-44329 IN denotes of
T21941 44330-44334 DT denotes this
T21942 44335-44344 NN denotes procedure
T21943 44344-44346 , denotes ,
T21944 44346-44350 RB denotes then
T21945 44351-44353 PRP denotes we
T21946 44354-44359 RB denotes again
T21947 44364-44367 NN denotes BIC
T21948 44368-44370 TO denotes to
T21949 44371-44379 VB denotes consider
T21950 44380-44389 VBG denotes including
T21951 44390-44393 DT denotes the
T21952 44402-44406 NN denotes term
T21953 44394-44401 NN denotes sex*dom
T21954 44407-44409 IN denotes in
T21955 44410-44413 DT denotes the
T21956 44414-44419 NN denotes model
T21957 44419-44420 . denotes .
T21958 44420-44677 sentence denotes To determine which of the four models (Equations 2, 4, 6, and the model selection) is optimal, we empirically estimated the FDR for each model over a set of 3,000 genes randomly selected from the set of all genes detected as expressed in the liver samples.
T21959 44421-44423 TO denotes To
T21960 44424-44433 VB denotes determine
T21961 44531-44540 VBD denotes estimated
T21962 44434-44439 WDT denotes which
T21963 44504-44506 VBZ denotes is
T21964 44440-44442 IN denotes of
T21965 44443-44446 DT denotes the
T21966 44452-44458 NNS denotes models
T21967 44447-44451 CD denotes four
T21968 44459-44460 -LRB- denotes (
T21969 44476-44477 CD denotes 6
T21970 44460-44469 NNS denotes Equations
T21971 44470-44471 CD denotes 2
T21972 44471-44473 , denotes ,
T21973 44473-44474 CD denotes 4
T21974 44474-44476 , denotes ,
T21975 44477-44479 , denotes ,
T21976 44479-44482 CC denotes and
T21977 44483-44486 DT denotes the
T21978 44493-44502 NN denotes selection
T21979 44487-44492 NN denotes model
T21980 44502-44503 -RRB- denotes )
T21981 44507-44514 JJ denotes optimal
T21982 44514-44516 , denotes ,
T21983 44516-44518 PRP denotes we
T21984 44519-44530 RB denotes empirically
T21985 44541-44544 DT denotes the
T21986 44545-44548 NN denotes FDR
T21987 44549-44552 IN denotes for
T21988 44553-44557 DT denotes each
T21989 44558-44563 NN denotes model
T21990 44564-44568 IN denotes over
T21991 44569-44570 DT denotes a
T21992 44571-44574 NN denotes set
T21993 44575-44577 IN denotes of
T21994 44578-44583 CD denotes 3,000
T21995 44584-44589 NNS denotes genes
T21996 44590-44598 RB denotes randomly
T21997 44599-44607 VBN denotes selected
T21998 44608-44612 IN denotes from
T21999 44613-44616 DT denotes the
T22000 44617-44620 NN denotes set
T22001 44621-44623 IN denotes of
T22002 44624-44627 DT denotes all
T22003 44628-44633 NNS denotes genes
T22004 44634-44642 VBN denotes detected
T22005 44643-44645 IN denotes as
T22006 44646-44655 VBN denotes expressed
T22007 44656-44658 IN denotes in
T22008 44659-44662 DT denotes the
T22009 44669-44676 NNS denotes samples
T22010 44663-44668 NN denotes liver
T22011 44676-44677 . denotes .
T22012 44677-44758 sentence denotes For each gene and for each marker we fitted each of the four models to the data.
T22013 44678-44681 IN denotes For
T22014 44715-44721 VBD denotes fitted
T22015 44682-44686 DT denotes each
T22016 44687-44691 NN denotes gene
T22017 44692-44695 CC denotes and
T22018 44696-44699 IN denotes for
T22019 44700-44704 DT denotes each
T22020 44705-44711 NN denotes marker
T22021 44712-44714 PRP denotes we
T22022 44722-44726 DT denotes each
T22023 44727-44729 IN denotes of
T22024 44730-44733 DT denotes the
T22025 44739-44745 NNS denotes models
T22026 44734-44738 CD denotes four
T22027 44746-44748 IN denotes to
T22028 44749-44752 DT denotes the
T22029 44753-44757 NNS denotes data
T22030 44757-44758 . denotes .
T22031 44758-44960 sentence denotes We performed this same analysis on ten separate permutation sets in which each of the 3,000 gene expression trait vectors was permuted such that the correlation structure among the genes was preserved.
T22032 44759-44761 PRP denotes We
T22033 44762-44771 VBD denotes performed
T22034 44772-44776 DT denotes this
T22035 44782-44790 NN denotes analysis
T22036 44777-44781 JJ denotes same
T22037 44791-44793 IN denotes on
T22038 44794-44797 CD denotes ten
T22039 44819-44823 NNS denotes sets
T22040 44798-44806 JJ denotes separate
T22041 44807-44818 NN denotes permutation
T22042 44824-44826 IN denotes in
T22043 44885-44893 VBN denotes permuted
T22044 44827-44832 WDT denotes which
T22045 44833-44837 DT denotes each
T22046 44838-44840 IN denotes of
T22047 44841-44844 DT denotes the
T22048 44873-44880 NNS denotes vectors
T22049 44845-44850 CD denotes 3,000
T22050 44851-44855 NN denotes gene
T22051 44856-44866 NN denotes expression
T22052 44867-44872 NN denotes trait
T22053 44881-44884 VBD denotes was
T22054 44894-44898 JJ denotes such
T22055 44950-44959 VBN denotes preserved
T22056 44899-44903 IN denotes that
T22057 44904-44907 DT denotes the
T22058 44920-44929 NN denotes structure
T22059 44908-44919 NN denotes correlation
T22060 44930-44935 IN denotes among
T22061 44936-44939 DT denotes the
T22062 44940-44945 NNS denotes genes
T22063 44946-44949 VBD denotes was
T22064 44959-44960 . denotes .
T22065 44960-45212 sentence denotes The FDR for a given LOD score threshold was then computed as the ratio of the mean number of QTL detected in the permuted datasets (the mean taken over the ten permuted datasets) and the total number of QTL detected in the observed 3,000-gene dataset.
T22066 44961-44964 DT denotes The
T22067 44965-44968 NN denotes FDR
T22068 45010-45018 VBN denotes computed
T22069 44969-44972 IN denotes for
T22070 44973-44974 DT denotes a
T22071 44991-45000 NN denotes threshold
T22072 44975-44980 JJ denotes given
T22073 44981-44984 NN denotes LOD
T22074 44985-44990 NN denotes score
T22075 45001-45004 VBD denotes was
T22076 45005-45009 RB denotes then
T22077 45019-45021 IN denotes as
T22078 45022-45025 DT denotes the
T22079 45026-45031 NN denotes ratio
T22080 45032-45034 IN denotes of
T22081 45035-45038 DT denotes the
T22082 45044-45050 NN denotes number
T22083 45039-45043 JJ denotes mean
T22084 45051-45053 IN denotes of
T22085 45054-45057 NN denotes QTL
T22086 45058-45066 VBN denotes detected
T22087 45067-45069 IN denotes in
T22088 45070-45073 DT denotes the
T22089 45083-45091 NNS denotes datasets
T22090 45074-45082 VBN denotes permuted
T22091 45092-45093 -LRB- denotes (
T22092 45097-45101 NN denotes mean
T22093 45093-45096 DT denotes the
T22094 45102-45107 VBN denotes taken
T22095 45108-45112 IN denotes over
T22096 45113-45116 DT denotes the
T22097 45130-45138 NNS denotes datasets
T22098 45117-45120 CD denotes ten
T22099 45121-45129 VBN denotes permuted
T22100 45138-45139 -RRB- denotes )
T22101 45140-45143 CC denotes and
T22102 45144-45147 DT denotes the
T22103 45154-45160 NN denotes number
T22104 45148-45153 JJ denotes total
T22105 45161-45163 IN denotes of
T22106 45164-45167 NN denotes QTL
T22107 45168-45176 VBN denotes detected
T22108 45177-45179 IN denotes in
T22109 45180-45183 DT denotes the
T22110 45204-45211 NN denotes dataset
T22111 45184-45192 VBN denotes observed
T22112 45193-45198 CD denotes 3,000
T22113 45199-45203 NN denotes gene
T22114 45198-45199 HYPH denotes -
T22115 45211-45212 . denotes .
T22116 45212-45339 sentence denotes We then generated ROC-like curves by varying the LOD score threshold, resulting in a range of FDRs (from 0% to more than 50%).
T22117 45213-45215 PRP denotes We
T22118 45221-45230 VBD denotes generated
T22119 45216-45220 RB denotes then
T22120 45231-45234 JJ denotes ROC
T22121 45235-45239 JJ denotes like
T22122 45234-45235 HYPH denotes -
T22123 45240-45246 NNS denotes curves
T22124 45247-45249 IN denotes by
T22125 45250-45257 VBG denotes varying
T22126 45258-45261 DT denotes the
T22127 45272-45281 NN denotes threshold
T22128 45262-45265 NN denotes LOD
T22129 45266-45271 NN denotes score
T22130 45281-45283 , denotes ,
T22131 45283-45292 VBG denotes resulting
T22132 45293-45295 IN denotes in
T22133 45296-45297 DT denotes a
T22134 45298-45303 NN denotes range
T22135 45304-45306 IN denotes of
T22136 45307-45311 NNS denotes FDRs
T22137 45312-45313 -LRB- denotes (
T22138 45321-45323 IN denotes to
T22139 45313-45317 IN denotes from
T22140 45318-45319 CD denotes 0
T22141 45319-45320 NN denotes %
T22142 45324-45328 JJR denotes more
T22143 45334-45336 CD denotes 50
T22144 45329-45333 IN denotes than
T22145 45336-45337 NN denotes %
T22146 45337-45338 -RRB- denotes )
T22147 45338-45339 . denotes .
T22148 45339-45535 sentence denotes To simplify this type of summary, we considered no more than one QTL per chromosome per gene expression trait by considering only the QTL with the max LOD score on each chromosome for each trait.
T22149 45340-45342 TO denotes To
T22150 45343-45351 VB denotes simplify
T22151 45377-45387 VBD denotes considered
T22152 45352-45356 DT denotes this
T22153 45357-45361 NN denotes type
T22154 45362-45364 IN denotes of
T22155 45365-45372 NN denotes summary
T22156 45372-45374 , denotes ,
T22157 45374-45376 PRP denotes we
T22158 45388-45390 DT denotes no
T22159 45391-45395 JJR denotes more
T22160 45396-45400 IN denotes than
T22161 45401-45404 CD denotes one
T22162 45405-45408 NN denotes QTL
T22163 45409-45412 IN denotes per
T22164 45413-45423 NN denotes chromosome
T22165 45424-45427 IN denotes per
T22166 45428-45432 NN denotes gene
T22167 45433-45443 NN denotes expression
T22168 45444-45449 NN denotes trait
T22169 45450-45452 IN denotes by
T22170 45453-45464 VBG denotes considering
T22171 45465-45469 RB denotes only
T22172 45474-45477 NN denotes QTL
T22173 45470-45473 DT denotes the
T22174 45478-45482 IN denotes with
T22175 45483-45486 DT denotes the
T22176 45495-45500 NN denotes score
T22177 45487-45490 NN denotes max
T22178 45491-45494 NN denotes LOD
T22179 45501-45503 IN denotes on
T22180 45504-45508 DT denotes each
T22181 45509-45519 NN denotes chromosome
T22182 45520-45523 IN denotes for
T22183 45524-45528 DT denotes each
T22184 45529-45534 NN denotes trait
T22185 45534-45535 . denotes .
T22186 45535-45807 sentence denotes The ROC curves for each of the four models are shown in Figure S1, with the black curve corresponding to Equation 2, the blue curve corresponding to Equation 4, the red curve corresponding to Equation 6, and the green curve corresponding to the model selection procedure.
T22187 45536-45539 DT denotes The
T22188 45544-45550 NNS denotes curves
T22189 45540-45543 NN denotes ROC
T22190 45583-45588 VBN denotes shown
T22191 45551-45554 IN denotes for
T22192 45555-45559 DT denotes each
T22193 45560-45562 IN denotes of
T22194 45563-45566 DT denotes the
T22195 45572-45578 NNS denotes models
T22196 45567-45571 CD denotes four
T22197 45579-45582 VBP denotes are
T22198 45589-45591 IN denotes in
T22199 45592-45598 NN denotes Figure
T22200 45599-45601 NN denotes S1
T22201 45601-45603 , denotes ,
T22202 45603-45607 IN denotes with
T22203 45624-45637 VBG denotes corresponding
T22204 45608-45611 DT denotes the
T22205 45618-45623 NN denotes curve
T22206 45612-45617 JJ denotes black
T22207 45638-45640 IN denotes to
T22208 45641-45649 NN denotes Equation
T22209 45650-45651 CD denotes 2
T22210 45651-45653 , denotes ,
T22211 45653-45656 DT denotes the
T22212 45662-45667 NN denotes curve
T22213 45657-45661 JJ denotes blue
T22214 45668-45681 VBG denotes corresponding
T22215 45682-45684 IN denotes to
T22216 45685-45693 NN denotes Equation
T22217 45694-45695 CD denotes 4
T22218 45695-45697 , denotes ,
T22219 45697-45700 DT denotes the
T22220 45705-45710 NN denotes curve
T22221 45701-45704 JJ denotes red
T22222 45711-45724 VBG denotes corresponding
T22223 45725-45727 IN denotes to
T22224 45728-45736 NN denotes Equation
T22225 45737-45738 CD denotes 6
T22226 45738-45740 , denotes ,
T22227 45740-45743 CC denotes and
T22228 45744-45747 DT denotes the
T22229 45754-45759 NN denotes curve
T22230 45748-45753 JJ denotes green
T22231 45760-45773 VBG denotes corresponding
T22232 45774-45776 IN denotes to
T22233 45777-45780 DT denotes the
T22234 45797-45806 NN denotes procedure
T22235 45781-45786 NN denotes model
T22236 45787-45796 NN denotes selection
T22237 45806-45807 . denotes .
T22238 45807-45926 sentence denotes It is clear from the ROC curves that the sex and sex-interaction terms are significant in the gene expression dataset.
T22239 45808-45810 PRP denotes It
T22240 45811-45813 VBZ denotes is
T22241 45814-45819 JJ denotes clear
T22242 45820-45824 IN denotes from
T22243 45825-45828 DT denotes the
T22244 45829-45832 NN denotes ROC
T22245 45833-45839 VBZ denotes curves
T22246 45840-45844 IN denotes that
T22247 45879-45882 VBP denotes are
T22248 45845-45848 DT denotes the
T22249 45873-45878 NNS denotes terms
T22250 45849-45852 NN denotes sex
T22251 45853-45856 CC denotes and
T22252 45857-45860 NN denotes sex
T22253 45861-45872 NN denotes interaction
T22254 45860-45861 HYPH denotes -
T22255 45883-45894 JJ denotes significant
T22256 45895-45897 IN denotes in
T22257 45898-45901 DT denotes the
T22258 45918-45925 NN denotes dataset
T22259 45902-45906 NN denotes gene
T22260 45907-45917 NN denotes expression
T22261 45925-45926 . denotes .
T22262 45926-46136 sentence denotes For example, at an FDR of 5% we note that 800 QTLs were detected in the set of 3,000 genes for model 1, while 968 (21% increase) and 1,159 (45% increase) QTLs were detected for Equations 4 and 6, respectively.
T22263 45927-45930 IN denotes For
T22264 45959-45963 VBP denotes note
T22265 45931-45938 NN denotes example
T22266 45938-45940 , denotes ,
T22267 45940-45942 IN denotes at
T22268 45943-45945 DT denotes an
T22269 45946-45949 NN denotes FDR
T22270 45950-45952 IN denotes of
T22271 45953-45954 CD denotes 5
T22272 45954-45955 NN denotes %
T22273 45956-45958 PRP denotes we
T22274 45964-45968 IN denotes that
T22275 45983-45991 VBN denotes detected
T22276 45969-45972 CD denotes 800
T22277 45973-45977 NNS denotes QTLs
T22278 45978-45982 VBD denotes were
T22279 45992-45994 IN denotes in
T22280 45995-45998 DT denotes the
T22281 45999-46002 NN denotes set
T22282 46003-46005 IN denotes of
T22283 46006-46011 CD denotes 3,000
T22284 46012-46017 NNS denotes genes
T22285 46018-46021 IN denotes for
T22286 46022-46027 NN denotes model
T22287 46028-46029 CD denotes 1
T22288 46029-46031 , denotes ,
T22289 46031-46036 IN denotes while
T22290 46091-46099 VBN denotes detected
T22291 46037-46040 CD denotes 968
T22292 46081-46085 NNS denotes QTLs
T22293 46041-46042 -LRB- denotes (
T22294 46046-46054 NN denotes increase
T22295 46042-46044 CD denotes 21
T22296 46044-46045 NN denotes %
T22297 46054-46055 -RRB- denotes )
T22298 46056-46059 CC denotes and
T22299 46060-46065 CD denotes 1,159
T22300 46066-46067 -LRB- denotes (
T22301 46071-46079 NN denotes increase
T22302 46067-46069 CD denotes 45
T22303 46069-46070 NN denotes %
T22304 46079-46080 -RRB- denotes )
T22305 46086-46090 VBD denotes were
T22306 46100-46103 IN denotes for
T22307 46104-46113 NNS denotes Equations
T22308 46114-46115 CD denotes 4
T22309 46116-46119 CC denotes and
T22310 46120-46121 CD denotes 6
T22311 46121-46123 , denotes ,
T22312 46123-46135 RB denotes respectively
T22313 46135-46136 . denotes .
T22314 46136-46239 sentence denotes These results demonstrate significantly increased power to detect QTLs when sex is taken into account.
T22315 46137-46142 DT denotes These
T22316 46143-46150 NNS denotes results
T22317 46151-46162 VBP denotes demonstrate
T22318 46163-46176 RB denotes significantly
T22319 46177-46186 VBN denotes increased
T22320 46187-46192 NN denotes power
T22321 46193-46195 TO denotes to
T22322 46196-46202 VB denotes detect
T22323 46203-46207 NNS denotes QTLs
T22324 46208-46212 WRB denotes when
T22325 46220-46225 VBN denotes taken
T22326 46213-46216 NN denotes sex
T22327 46217-46219 VBZ denotes is
T22328 46226-46230 IN denotes into
T22329 46231-46238 NN denotes account
T22330 46238-46239 . denotes .
T22331 46239-46555 sentence denotes We further note that the stepwise selection procedure captures more information than Equation 4, indicating a significant interaction signature in this dataset and also demonstrating that this simple statistical procedure is capable of identifying significant interaction events even at conservative FDR thresholds.
T22332 46240-46242 PRP denotes We
T22333 46251-46255 VBP denotes note
T22334 46243-46250 RB denotes further
T22335 46256-46260 IN denotes that
T22336 46294-46302 VBZ denotes captures
T22337 46261-46264 DT denotes the
T22338 46284-46293 NN denotes procedure
T22339 46265-46273 JJ denotes stepwise
T22340 46274-46283 NN denotes selection
T22341 46303-46307 JJR denotes more
T22342 46308-46319 NN denotes information
T22343 46320-46324 IN denotes than
T22344 46325-46333 NN denotes Equation
T22345 46334-46335 CD denotes 4
T22346 46335-46337 , denotes ,
T22347 46337-46347 VBG denotes indicating
T22348 46348-46349 DT denotes a
T22349 46374-46383 NN denotes signature
T22350 46350-46361 JJ denotes significant
T22351 46362-46373 NN denotes interaction
T22352 46384-46386 IN denotes in
T22353 46387-46391 DT denotes this
T22354 46392-46399 NN denotes dataset
T22355 46400-46403 CC denotes and
T22356 46404-46408 RB denotes also
T22357 46409-46422 VBG denotes demonstrating
T22358 46423-46427 IN denotes that
T22359 46462-46464 VBZ denotes is
T22360 46428-46432 DT denotes this
T22361 46452-46461 NN denotes procedure
T22362 46433-46439 JJ denotes simple
T22363 46440-46451 JJ denotes statistical
T22364 46465-46472 JJ denotes capable
T22365 46473-46475 IN denotes of
T22366 46476-46487 VBG denotes identifying
T22367 46488-46499 JJ denotes significant
T22368 46512-46518 NNS denotes events
T22369 46500-46511 NN denotes interaction
T22370 46519-46523 RB denotes even
T22371 46524-46526 IN denotes at
T22372 46527-46539 JJ denotes conservative
T22373 46544-46554 NNS denotes thresholds
T22374 46540-46543 NN denotes FDR
T22375 46554-46555 . denotes .
T22376 46555-46703 sentence denotes Finally, it is of particular note that Equation 4 performed better than Equation 6, the model that incorporated the interaction terms at all times.
T22377 46556-46563 RB denotes Finally
T22378 46568-46570 VBZ denotes is
T22379 46563-46565 , denotes ,
T22380 46565-46567 PRP denotes it
T22381 46571-46573 IN denotes of
T22382 46574-46584 JJ denotes particular
T22383 46585-46589 NN denotes note
T22384 46590-46594 IN denotes that
T22385 46606-46615 VBD denotes performed
T22386 46595-46603 NN denotes Equation
T22387 46604-46605 CD denotes 4
T22388 46616-46622 RBR denotes better
T22389 46623-46627 IN denotes than
T22390 46628-46636 NN denotes Equation
T22391 46637-46638 CD denotes 6
T22392 46638-46640 , denotes ,
T22393 46640-46643 DT denotes the
T22394 46644-46649 NN denotes model
T22395 46650-46654 WDT denotes that
T22396 46655-46667 VBD denotes incorporated
T22397 46668-46671 DT denotes the
T22398 46684-46689 NNS denotes terms
T22399 46672-46683 NN denotes interaction
T22400 46690-46692 IN denotes at
T22401 46693-46696 DT denotes all
T22402 46697-46702 NNS denotes times
T22403 46702-46703 . denotes .
T22404 46703-46898 sentence denotes That is, despite there being a significant interaction signature, the signature was not large enough to justify including interaction terms for every expression trait and at every marker tested.
T22405 46704-46708 RB denotes That
T22406 46709-46711 RB denotes is
T22407 46784-46787 VBD denotes was
T22408 46711-46713 , denotes ,
T22409 46713-46720 IN denotes despite
T22410 46727-46732 VBG denotes being
T22411 46721-46726 EX denotes there
T22412 46733-46734 DT denotes a
T22413 46759-46768 NN denotes signature
T22414 46735-46746 JJ denotes significant
T22415 46747-46758 NN denotes interaction
T22416 46768-46770 , denotes ,
T22417 46770-46773 DT denotes the
T22418 46774-46783 NN denotes signature
T22419 46788-46791 RB denotes not
T22420 46792-46797 JJ denotes large
T22421 46798-46804 RB denotes enough
T22422 46805-46807 TO denotes to
T22423 46808-46815 VB denotes justify
T22424 46816-46825 VBG denotes including
T22425 46826-46837 NN denotes interaction
T22426 46838-46843 NNS denotes terms
T22427 46844-46847 IN denotes for
T22428 46848-46853 DT denotes every
T22429 46865-46870 NN denotes trait
T22430 46854-46864 NN denotes expression
T22431 46871-46874 CC denotes and
T22432 46875-46877 IN denotes at
T22433 46878-46883 DT denotes every
T22434 46884-46890 NN denotes marker
T22435 46891-46897 VBN denotes tested
T22436 46897-46898 . denotes .
T22437 46898-47149 sentence denotes This fact motivated the need to employ the forward regression procedure, and these results further motivate the need to explore sex effects by employing even more sophisticated QTL detection methods, such as that recently described by Yi et al. [38].
T22438 46899-46903 DT denotes This
T22439 46904-46908 NN denotes fact
T22440 46909-46918 VBD denotes motivated
T22441 46919-46922 DT denotes the
T22442 46923-46927 NN denotes need
T22443 46928-46930 TO denotes to
T22444 46931-46937 VB denotes employ
T22445 46938-46941 DT denotes the
T22446 46961-46970 NN denotes procedure
T22447 46942-46949 JJ denotes forward
T22448 46950-46960 NN denotes regression
T22449 46970-46972 , denotes ,
T22450 46972-46975 CC denotes and
T22451 46976-46981 DT denotes these
T22452 46982-46989 NNS denotes results
T22453 46998-47006 VBP denotes motivate
T22454 46990-46997 RB denotes further
T22455 47007-47010 DT denotes the
T22456 47011-47015 NN denotes need
T22457 47016-47018 TO denotes to
T22458 47019-47026 VB denotes explore
T22459 47027-47030 NN denotes sex
T22460 47031-47038 NNS denotes effects
T22461 47039-47041 IN denotes by
T22462 47042-47051 VBG denotes employing
T22463 47052-47056 RB denotes even
T22464 47057-47061 RBR denotes more
T22465 47062-47075 JJ denotes sophisticated
T22466 47090-47097 NNS denotes methods
T22467 47076-47079 NN denotes QTL
T22468 47080-47089 NN denotes detection
T22469 47097-47099 , denotes ,
T22470 47099-47103 JJ denotes such
T22471 47104-47106 IN denotes as
T22472 47107-47111 DT denotes that
T22473 47112-47120 RB denotes recently
T22474 47121-47130 VBN denotes described
T22475 47131-47133 IN denotes by
T22476 47134-47136 NNP denotes Yi
T22477 47137-47139 FW denotes et
T22478 47140-47143 FW denotes al.
T22479 47144-47145 -LRB- denotes [
T22480 47145-47147 CD denotes 38
T22481 47147-47148 -RRB- denotes ]
T22482 47148-47149 . denotes .
T23070 47151-47161 JJ denotes Additional
T23071 47162-47172 NNS denotes statistics
T23072 47172-47173 . denotes .
T23073 47173-47357 sentence denotes For each 23,574 oligonucleotides represented on the array, we computed a linear regression analysis to test for a correlation between the trait “gonadal fat mass” and each transcript.
T23074 47174-47177 IN denotes For
T23075 47236-47244 VBD denotes computed
T23076 47178-47182 DT denotes each
T23077 47190-47206 NNS denotes oligonucleotides
T23078 47183-47189 CD denotes 23,574
T23079 47207-47218 VBN denotes represented
T23080 47219-47221 IN denotes on
T23081 47222-47225 DT denotes the
T23082 47226-47231 NN denotes array
T23083 47231-47233 , denotes ,
T23084 47233-47235 PRP denotes we
T23085 47245-47246 DT denotes a
T23086 47265-47273 NN denotes analysis
T23087 47247-47253 JJ denotes linear
T23088 47254-47264 NN denotes regression
T23089 47274-47276 TO denotes to
T23090 47277-47281 VB denotes test
T23091 47282-47285 IN denotes for
T23092 47286-47287 DT denotes a
T23093 47288-47299 NN denotes correlation
T23094 47300-47307 IN denotes between
T23095 47308-47311 DT denotes the
T23096 47312-47317 NN denotes trait
T23097 47318-47319 `` denotes “
T23098 47319-47326 JJ denotes gonadal
T23099 47331-47335 NN denotes mass
T23100 47327-47330 NN denotes fat
T23101 47335-47336 '' denotes ”
T23102 47337-47340 CC denotes and
T23103 47341-47345 DT denotes each
T23104 47346-47356 NN denotes transcript
T23105 47356-47357 . denotes .
T23106 47357-47623 sentence denotes Similar to our method of calculating linkage, we employed a stepwise linear regression procedure using equations of the form or compared to the null model where β0 is the intercept, and β1, β2, and β3 represent the regression coefficients of their respective terms.
T23107 47358-47365 JJ denotes Similar
T23108 47407-47415 VBD denotes employed
T23109 47366-47368 IN denotes to
T23110 47369-47372 PRP$ denotes our
T23111 47373-47379 NN denotes method
T23112 47380-47382 IN denotes of
T23113 47383-47394 VBG denotes calculating
T23114 47395-47402 NN denotes linkage
T23115 47402-47404 , denotes ,
T23116 47404-47406 PRP denotes we
T23117 47416-47417 DT denotes a
T23118 47445-47454 NN denotes procedure
T23119 47418-47426 JJ denotes stepwise
T23120 47434-47444 NN denotes regression
T23121 47427-47433 JJ denotes linear
T23122 47455-47460 VBG denotes using
T23123 47461-47470 NNS denotes equations
T23124 47471-47473 IN denotes of
T23125 47474-47477 DT denotes the
T23126 47478-47482 NN denotes form
T23127 47483-47485 CC denotes or
T23128 47486-47494 VBN denotes compared
T23129 47495-47497 IN denotes to
T23130 47498-47501 DT denotes the
T23131 47507-47512 NN denotes model
T23132 47502-47506 JJ denotes null
T23133 47513-47518 WRB denotes where
T23134 47522-47524 VBZ denotes is
T23135 47519-47521 NN denotes β0
T23136 47525-47528 DT denotes the
T23137 47529-47538 NN denotes intercept
T23138 47538-47540 , denotes ,
T23139 47540-47543 CC denotes and
T23140 47544-47546 NN denotes β1
T23141 47559-47568 VBP denotes represent
T23142 47546-47548 , denotes ,
T23143 47548-47550 NN denotes β2
T23144 47550-47552 , denotes ,
T23145 47552-47555 CC denotes and
T23146 47556-47558 NN denotes β3
T23147 47569-47572 DT denotes the
T23148 47584-47596 NNS denotes coefficients
T23149 47573-47583 NN denotes regression
T23150 47597-47599 IN denotes of
T23151 47600-47605 PRP$ denotes their
T23152 47617-47622 NNS denotes terms
T23153 47606-47616 JJ denotes respective
T23154 47622-47623 . denotes .
T23155 47623-47727 sentence denotes As before, the parameter “sex*gene” is only retained if it significantly improves the fit of the model.
T23156 47624-47626 IN denotes As
T23157 47668-47676 VBN denotes retained
T23158 47627-47633 RB denotes before
T23159 47633-47635 , denotes ,
T23160 47635-47638 DT denotes the
T23161 47639-47648 NN denotes parameter
T23162 47649-47650 `` denotes “
T23163 47650-47653 NN denotes sex
T23164 47653-47654 SYM denotes *
T23165 47654-47658 NN denotes gene
T23166 47658-47659 '' denotes ”
T23167 47660-47662 VBZ denotes is
T23168 47663-47667 RB denotes only
T23169 47677-47679 IN denotes if
T23170 47697-47705 VBZ denotes improves
T23171 47680-47682 PRP denotes it
T23172 47683-47696 RB denotes significantly
T23173 47706-47709 DT denotes the
T23174 47710-47713 NN denotes fit
T23175 47714-47716 IN denotes of
T23176 47717-47720 DT denotes the
T23177 47721-47726 NN denotes model
T23178 47726-47727 . denotes .
T23179 47727-47892 sentence denotes The p-value threshold for significant correlation is calculated by an F test, which compares the appropriate model (Equation 7 or 8) to the null model (Equation 9).
T23180 47728-47731 DT denotes The
T23181 47740-47749 NN denotes threshold
T23182 47732-47733 NN denotes p
T23183 47734-47739 NN denotes value
T23184 47733-47734 HYPH denotes -
T23185 47781-47791 VBN denotes calculated
T23186 47750-47753 IN denotes for
T23187 47754-47765 JJ denotes significant
T23188 47766-47777 NN denotes correlation
T23189 47778-47780 VBZ denotes is
T23190 47792-47794 IN denotes by
T23191 47795-47797 DT denotes an
T23192 47800-47804 NN denotes test
T23193 47798-47799 NN denotes F
T23194 47804-47806 , denotes ,
T23195 47806-47811 WDT denotes which
T23196 47812-47820 VBZ denotes compares
T23197 47821-47824 DT denotes the
T23198 47837-47842 NN denotes model
T23199 47825-47836 JJ denotes appropriate
T23200 47843-47844 -LRB- denotes (
T23201 47853-47854 CD denotes 7
T23202 47844-47852 NN denotes Equation
T23203 47855-47857 CC denotes or
T23204 47858-47859 CD denotes 8
T23205 47859-47860 -RRB- denotes )
T23206 47861-47863 IN denotes to
T23207 47864-47867 DT denotes the
T23208 47873-47878 NN denotes model
T23209 47868-47872 JJ denotes null
T23210 47879-47880 -LRB- denotes (
T23211 47880-47888 NN denotes Equation
T23212 47889-47890 CD denotes 9
T23213 47890-47891 -RRB- denotes )
T23214 47891-47892 . denotes .
T23215 47892-48030 sentence denotes As before, multiple testing was addressed with use of the FDR, ranking the p-values obtained from the above F tests and setting α = 0.01.
T23216 47893-47895 IN denotes As
T23217 47925-47934 VBN denotes addressed
T23218 47896-47902 RB denotes before
T23219 47902-47904 , denotes ,
T23220 47904-47912 JJ denotes multiple
T23221 47913-47920 NN denotes testing
T23222 47921-47924 VBD denotes was
T23223 47935-47939 IN denotes with
T23224 47940-47943 NN denotes use
T23225 47944-47946 IN denotes of
T23226 47947-47950 DT denotes the
T23227 47951-47954 NN denotes FDR
T23228 47954-47956 , denotes ,
T23229 47956-47963 VBG denotes ranking
T23230 47964-47967 DT denotes the
T23231 47970-47976 NNS denotes values
T23232 47968-47969 NN denotes p
T23233 47969-47970 HYPH denotes -
T23234 47977-47985 VBN denotes obtained
T23235 47986-47990 IN denotes from
T23236 47991-47994 DT denotes the
T23237 48003-48008 NNS denotes tests
T23238 47995-48000 JJ denotes above
T23239 48001-48002 NN denotes F
T23240 48009-48012 CC denotes and
T23241 48013-48020 VBG denotes setting
T23242 48021-48022 NN denotes α
T23243 48025-48029 CD denotes 0.01
T23244 48023-48024 SYM denotes =
T23245 48029-48030 . denotes .
T23246 48030-48116 sentence denotes Genes correlated with the gonadal fat mass trait generated several significant eQTLs.
T23247 48031-48036 NNS denotes Genes
T23248 48080-48089 VBD denotes generated
T23249 48037-48047 VBN denotes correlated
T23250 48048-48052 IN denotes with
T23251 48053-48056 DT denotes the
T23252 48074-48079 NN denotes trait
T23253 48057-48064 JJ denotes gonadal
T23254 48069-48073 NN denotes mass
T23255 48065-48068 NN denotes fat
T23256 48090-48097 JJ denotes several
T23257 48110-48115 NNS denotes eQTLs
T23258 48098-48109 JJ denotes significant
T23259 48115-48116 . denotes .
T23260 48116-48397 sentence denotes In order to determine if eQTLs generated by these genes were enriched in any locus or if they were distributed randomly, we compared the distribution of these eQTLs against the distribution of all liver eQTLs in overlapping 6-cM bins across the genome using the Fisher exact test.
T23261 48117-48119 IN denotes In
T23262 48241-48249 VBD denotes compared
T23263 48120-48125 NN denotes order
T23264 48126-48128 TO denotes to
T23265 48129-48138 VB denotes determine
T23266 48139-48141 IN denotes if
T23267 48178-48186 VBN denotes enriched
T23268 48142-48147 NNS denotes eQTLs
T23269 48148-48157 VBN denotes generated
T23270 48158-48160 IN denotes by
T23271 48161-48166 DT denotes these
T23272 48167-48172 NNS denotes genes
T23273 48173-48177 VBD denotes were
T23274 48187-48189 IN denotes in
T23275 48190-48193 DT denotes any
T23276 48194-48199 NN denotes locus
T23277 48200-48202 CC denotes or
T23278 48203-48205 IN denotes if
T23279 48216-48227 VBN denotes distributed
T23280 48206-48210 PRP denotes they
T23281 48211-48215 VBD denotes were
T23282 48228-48236 RB denotes randomly
T23283 48236-48238 , denotes ,
T23284 48238-48240 PRP denotes we
T23285 48250-48253 DT denotes the
T23286 48254-48266 NN denotes distribution
T23287 48267-48269 IN denotes of
T23288 48270-48275 DT denotes these
T23289 48276-48281 NNS denotes eQTLs
T23290 48282-48289 IN denotes against
T23291 48290-48293 DT denotes the
T23292 48294-48306 NN denotes distribution
T23293 48307-48309 IN denotes of
T23294 48310-48313 DT denotes all
T23295 48320-48325 NNS denotes eQTLs
T23296 48314-48319 NN denotes liver
T23297 48326-48328 IN denotes in
T23298 48329-48340 VBG denotes overlapping
T23299 48346-48350 NNS denotes bins
T23300 48341-48342 CD denotes 6
T23301 48343-48345 NN denotes cM
T23302 48342-48343 HYPH denotes -
T23303 48351-48357 IN denotes across
T23304 48358-48361 DT denotes the
T23305 48362-48368 NN denotes genome
T23306 48369-48374 VBG denotes using
T23307 48375-48378 DT denotes the
T23308 48392-48396 NN denotes test
T23309 48379-48385 NNP denotes Fisher
T23310 48386-48391 JJ denotes exact
T23311 48396-48397 . denotes .
T23312 48397-48499 sentence denotes This test is based on exact probabilities from a specific distribution (hypergeometric distribution).
T23313 48398-48402 DT denotes This
T23314 48403-48407 NN denotes test
T23315 48411-48416 VBN denotes based
T23316 48408-48410 VBZ denotes is
T23317 48417-48419 IN denotes on
T23318 48420-48425 JJ denotes exact
T23319 48426-48439 NNS denotes probabilities
T23320 48440-48444 IN denotes from
T23321 48445-48446 DT denotes a
T23322 48456-48468 NN denotes distribution
T23323 48447-48455 JJ denotes specific
T23324 48469-48470 -LRB- denotes (
T23325 48485-48497 NN denotes distribution
T23326 48470-48484 JJ denotes hypergeometric
T23327 48497-48498 -RRB- denotes )
T23328 48498-48499 . denotes .
T23329 48499-48674 sentence denotes p-Values obtained from this test were corrected for multiple comparisons using a simple Bonferonni correction (given that we performed 772 tests across the genome, 0.05/772).
T23330 48500-48501 NN denotes p
T23331 48502-48508 NNS denotes Values
T23332 48501-48502 HYPH denotes -
T23333 48538-48547 VBN denotes corrected
T23334 48509-48517 VBN denotes obtained
T23335 48518-48522 IN denotes from
T23336 48523-48527 DT denotes this
T23337 48528-48532 NN denotes test
T23338 48533-48537 VBD denotes were
T23339 48548-48551 IN denotes for
T23340 48552-48560 JJ denotes multiple
T23341 48561-48572 NNS denotes comparisons
T23342 48573-48578 VBG denotes using
T23343 48579-48580 DT denotes a
T23344 48599-48609 NN denotes correction
T23345 48581-48587 JJ denotes simple
T23346 48588-48598 NNP denotes Bonferonni
T23347 48610-48611 -LRB- denotes (
T23348 48669-48672 CD denotes 772
T23349 48611-48616 VBN denotes given
T23350 48617-48621 IN denotes that
T23351 48625-48634 VBD denotes performed
T23352 48622-48624 PRP denotes we
T23353 48635-48638 CD denotes 772
T23354 48639-48644 NNS denotes tests
T23355 48645-48651 IN denotes across
T23356 48652-48655 DT denotes the
T23357 48656-48662 NN denotes genome
T23358 48662-48664 , denotes ,
T23359 48664-48668 CD denotes 0.05
T23360 48668-48669 HYPH denotes /
T23361 48672-48673 -RRB- denotes )
T23362 48673-48674 . denotes .
T23363 48674-48803 sentence denotes Loci with p < 6.5 × 10−5 by Fisher exact test were considered significantly enriched for eQTLs correlated with gonadal fat mass.
T23364 48675-48679 NNS denotes Loci
T23365 48726-48736 VBN denotes considered
T23366 48680-48684 IN denotes with
T23367 48685-48686 NN denotes p
T23368 48687-48688 SYM denotes <
T23369 48689-48692 CD denotes 6.5
T23370 48693-48694 SYM denotes ×
T23371 48695-48697 CD denotes 10
T23372 48698-48699 CD denotes 5
T23373 48697-48698 SYM denotes −
T23374 48700-48702 IN denotes by
T23375 48703-48709 NNP denotes Fisher
T23376 48716-48720 NN denotes test
T23377 48710-48715 JJ denotes exact
T23378 48721-48725 VBD denotes were
T23379 48737-48750 RB denotes significantly
T23380 48751-48759 JJ denotes enriched
T23381 48760-48763 IN denotes for
T23382 48764-48769 NNS denotes eQTLs
T23383 48770-48780 VBN denotes correlated
T23384 48781-48785 IN denotes with
T23385 48786-48793 JJ denotes gonadal
T23386 48798-48802 NN denotes mass
T23387 48794-48797 NN denotes fat
T23388 48802-48803 . denotes .
T534 0-7 JJ denotes Genetic
R2679 T8448 T8449 compound Cis,eQTLs
R2680 T8449 T8451 nsubj eQTLs,Are
R2681 T8450 T8449 punct -,eQTLs
R2682 T8452 T8453 compound Candidate,Genes
R2683 T8453 T8451 attr Genes,Are
R2684 T8454 T8453 prep for,Genes
R2685 T8455 T8456 det the,Trait
R2686 T8456 T8454 pobj Trait,for
R2687 T8457 T8458 amod Gonadal,Mass
R2688 T8458 T8456 compound Mass,Trait
R2689 T8459 T8458 compound Fat,Mass
R2690 T8461 T8462 prep Given,reasoned
R2691 T8463 T8464 det the,effects
R2692 T8464 T8461 pobj effects,Given
R2693 T8465 T8464 amod marked,effects
R2694 T8466 T8464 prep of,effects
R2695 T8467 T8466 pobj sex,of
R2696 T8468 T8464 prep on,effects
R2697 T8469 T8470 compound liver,expression
R2698 T8470 T8468 pobj expression,on
R2699 T8471 T8470 compound gene,expression
R2700 T8472 T8464 cc and,effects
R2701 T8473 T8474 det the,regulation
R2702 T8474 T8464 conj regulation,effects
R2703 T8475 T8474 amod genetic,regulation
R2704 T8476 T8474 prep of,regulation
R2705 T8477 T8478 amod gonadal,mass
R2706 T8478 T8476 pobj mass,of
R2707 T8479 T8478 compound fat,mass
R2708 T8480 T8462 punct ", ",reasoned
R2709 T8481 T8462 nsubj we,reasoned
R2710 T8482 T8483 mark that,be
R2711 T8483 T8462 ccomp be,reasoned
R2712 T8484 T8485 compound cis,eQTLs
R2713 T8485 T8483 nsubj eQTLs,be
R2714 T8486 T8485 punct -,eQTLs
R2715 T8487 T8485 prep with,eQTLs
R2716 T8488 T8489 amod significant,interactions
R2717 T8489 T8487 pobj interactions,with
R2718 T8490 T8489 punct “,interactions
R2719 T8491 T8492 npadvmod sex,additive
R2720 T8492 T8489 amod additive,interactions
R2721 T8493 T8492 punct -,additive
R2722 T8494 T8492 punct ”,additive
R2723 T8495 T8492 cc and,additive
R2724 T8496 T8497 punct “,dominant
R2725 T8497 T8492 conj dominant,additive
R2726 T8498 T8497 npadvmod sex,dominant
R2727 T8499 T8497 punct -,dominant
R2728 T8500 T8489 punct ”,interactions
R2729 T8501 T8483 aux would,be
R2730 T8502 T8503 amod potential,genes
R2731 T8503 T8483 attr genes,be
R2732 T8504 T8503 compound candidate,genes
R2733 T8505 T8503 prep for,genes
R2734 T8506 T8507 poss our,trait
R2735 T8507 T8505 pobj trait,for
R2736 T8508 T8462 punct .,reasoned
R2737 T8510 T8511 prep Of,improved
R2738 T8512 T8513 det the,eQTLs
R2739 T8513 T8510 pobj eQTLs,Of
R2740 T8514 T8513 nummod "2,118",eQTLs
R2741 T8515 T8513 amod significant,eQTLs
R2742 T8516 T8513 compound cis,eQTLs
R2743 T8517 T8513 punct -,eQTLs
R2744 T8518 T8511 punct ", ",improved
R2745 T8519 T8511 nsubjpass 304,improved
R2746 T8520 T8521 punct (,%
R2747 T8521 T8519 parataxis %,304
R2748 T8522 T8521 nummod 14,%
R2749 T8523 T8521 punct ),%
R2750 T8524 T8511 auxpass were,improved
R2751 T8525 T8511 agent by,improved
R2752 T8526 T8527 det the,terms
R2753 T8527 T8525 pobj terms,by
R2754 T8528 T8529 compound sex,interaction
R2755 T8529 T8527 compound interaction,terms
R2756 T8530 T8529 punct -,interaction
R2757 T8531 T8511 punct .,improved
R2758 T8533 T8534 compound Cis,eQTLs
R2759 T8534 T8536 nsubj eQTLs,are
R2760 T8535 T8534 punct -,eQTLs
R2761 T8537 T8534 acl overlapping,eQTLs
R2762 T8538 T8539 det the,interval
R2763 T8539 T8537 dobj interval,overlapping
R2764 T8540 T8539 compound confidence,interval
R2765 T8541 T8539 prep for,interval
R2766 T8542 T8543 det the,cQTL
R2767 T8543 T8541 pobj cQTL,for
R2768 T8544 T8545 compound fat,mass
R2769 T8545 T8543 compound mass,cQTL
R2770 T8546 T8547 compound candidate,genes
R2771 T8547 T8536 attr genes,are
R2772 T8548 T8547 prep for,genes
R2773 T8549 T8550 det the,trait
R2774 T8550 T8548 pobj trait,for
R2775 T8551 T8536 punct .,are
R2776 T8553 T8554 det Those,genes
R2777 T8554 T8555 nsubj genes,receive
R2778 T8556 T8554 prep with,genes
R2779 T8557 T8558 amod significant,interactions
R2780 T8558 T8556 pobj interactions,with
R2781 T8559 T8558 compound sex,interactions
R2782 T8560 T8561 amod increased,consideration
R2783 T8561 T8555 dobj consideration,receive
R2784 T8562 T8555 prep as,receive
R2785 T8563 T8564 amod potential,candidates
R2786 T8564 T8562 pobj candidates,as
R2787 T8565 T8566 punct (,4
R2788 T8566 T8555 parataxis 4,receive
R2789 T8567 T8566 nmod Tables,4
R2790 T8568 T8566 cc and,4
R2791 T8569 T8566 conj 5,4
R2792 T8570 T8566 punct ),4
R2793 T8571 T8555 punct .,receive
R2797 T10517 T10518 nsubj Thousands,Show
R2798 T10519 T10517 prep of,Thousands
R2799 T10520 T10519 pobj Genes,of
R2800 T10521 T10522 det a,Correlation
R2801 T10522 T10518 dobj Correlation,Show
R2802 T10523 T10524 npadvmod Sex,Specific
R2803 T10524 T10522 amod Specific,Correlation
R2804 T10525 T10524 punct -,Specific
R2805 T10526 T10522 prep with,Correlation
R2806 T10527 T10528 amod Gonadal,Mass
R2807 T10528 T10526 pobj Mass,with
R2808 T10529 T10528 compound Fat,Mass
R2809 T10531 T10532 prep For,computed
R2810 T10533 T10531 pobj each,For
R2811 T10534 T10533 prep of,each
R2812 T10535 T10536 det the,oligonucleotides
R2813 T10536 T10534 pobj oligonucleotides,of
R2814 T10537 T10536 nummod "23,574",oligonucleotides
R2815 T10538 T10536 acl represented,oligonucleotides
R2816 T10539 T10538 prep on,represented
R2817 T10540 T10541 det the,array
R2818 T10541 T10539 pobj array,on
R2819 T10542 T10532 punct ", ",computed
R2820 T10543 T10532 nsubj we,computed
R2821 T10544 T10545 det a,analysis
R2822 T10545 T10532 dobj analysis,computed
R2823 T10546 T10547 amod linear,regression
R2824 T10547 T10545 compound regression,analysis
R2825 T10548 T10549 aux to,test
R2826 T10549 T10532 advcl test,computed
R2827 T10550 T10549 prep for,test
R2828 T10551 T10550 pobj association,for
R2829 T10552 T10551 prep between,association
R2830 T10553 T10554 det the,trait
R2831 T10554 T10552 pobj trait,between
R2832 T10555 T10554 punct “,trait
R2833 T10556 T10557 amod gonadal,mass
R2834 T10557 T10554 appos mass,trait
R2835 T10558 T10557 compound fat,mass
R2836 T10559 T10554 punct ”,trait
R2837 T10560 T10554 cc and,trait
R2838 T10561 T10562 det each,measure
R2839 T10562 T10554 conj measure,trait
R2840 T10563 T10564 compound transcript,abundance
R2841 T10564 T10562 compound abundance,measure
R2842 T10565 T10549 punct ", ",test
R2843 T10566 T10549 advcl incorporating,test
R2844 T10567 T10568 det the,terms
R2845 T10568 T10566 dobj terms,incorporating
R2846 T10569 T10568 punct “,terms
R2847 T10570 T10568 appos gene,terms
R2848 T10571 T10570 punct ",",gene
R2849 T10572 T10573 punct ”,sex
R2850 T10573 T10570 conj sex,gene
R2851 T10574 T10573 punct “,sex
R2852 T10575 T10573 punct ",",sex
R2853 T10576 T10573 punct ”,sex
R2854 T10577 T10573 cc and,sex
R2855 T10578 T10579 punct “,gene
R2856 T10579 T10573 conj gene,sex
R2857 T10580 T10579 punct -,gene
R2858 T10581 T10579 prep by,gene
R2859 T10582 T10581 punct -,by
R2860 T10583 T10581 pobj sex,by
R2861 T10584 T10566 punct ",",incorporating
R2862 T10585 T10566 punct ”,incorporating
R2863 T10586 T10587 advmod where,tests
R2864 T10587 T10566 advcl tests,incorporating
R2865 T10588 T10589 det the,parameter
R2866 T10589 T10587 nsubj parameter,tests
R2867 T10590 T10589 punct “,parameter
R2868 T10591 T10589 nmod gene,parameter
R2869 T10592 T10591 punct -,gene
R2870 T10593 T10591 prep by,gene
R2871 T10594 T10593 punct -,by
R2872 T10595 T10593 pobj sex,by
R2873 T10596 T10589 punct ”,parameter
R2874 T10597 T10587 prep for,tests
R2875 T10598 T10599 npadvmod sex,specific
R2876 T10599 T10601 amod specific,correlation
R2877 T10600 T10599 punct -,specific
R2878 T10601 T10597 pobj correlation,for
R2879 T10602 T10601 prep between,correlation
R2880 T10603 T10604 det a,gene
R2881 T10604 T10602 pobj gene,between
R2882 T10605 T10604 cc and,gene
R2883 T10606 T10607 det the,trait
R2884 T10607 T10604 conj trait,gene
R2885 T10608 T10532 punct .,computed
R2886 T10610 T10611 prep As,used
R2887 T10612 T10610 pcomp before,As
R2888 T10613 T10611 punct ", ",used
R2889 T10614 T10615 det a,procedure
R2890 T10615 T10611 nsubjpass procedure,used
R2891 T10616 T10615 compound stepwise,procedure
R2892 T10617 T10615 compound regression,procedure
R2893 T10618 T10611 auxpass was,used
R2894 T10619 T10620 aux to,determine
R2895 T10620 T10611 advcl determine,used
R2896 T10621 T10622 mark if,improved
R2897 T10622 T10620 ccomp improved,determine
R2898 T10623 T10624 det the,addition
R2899 T10624 T10622 nsubj addition,improved
R2900 T10625 T10624 prep of,addition
R2901 T10626 T10627 det the,term
R2902 T10627 T10625 pobj term,of
R2903 T10628 T10627 compound interaction,term
R2904 T10629 T10622 advmod significantly,improved
R2905 T10630 T10631 det the,fit
R2906 T10631 T10622 dobj fit,improved
R2907 T10632 T10631 compound model,fit
R2908 T10633 T10634 punct (,see
R2909 T10634 T10611 parataxis see,used
R2910 T10635 T10634 dobj Materials,see
R2911 T10636 T10635 cc and,Materials
R2912 T10637 T10635 conj Methods,Materials
R2913 T10638 T10634 punct ),see
R2914 T10639 T10611 punct .,used
R2915 T10641 T10642 amod Multiple,testing
R2916 T10642 T10643 nsubjpass testing,addressed
R2917 T10644 T10643 auxpass was,addressed
R2918 T10645 T10643 prep by,addressed
R2919 T10646 T10645 pcomp controlling,by
R2920 T10647 T10646 prep for,controlling
R2921 T10648 T10649 det the,FDR
R2922 T10649 T10647 pobj FDR,for
R2923 T10650 T10643 punct .,addressed
R2924 T10652 T10653 nsubjpass Distribution,shown
R2925 T10654 T10652 prep of,Distribution
R2926 T10655 T10656 det the,values
R2927 T10656 T10654 pobj values,of
R2928 T10657 T10656 compound p,values
R2929 T10658 T10656 punct -,values
R2930 T10659 T10656 acl obtained,values
R2931 T10660 T10659 prep from,obtained
R2932 T10661 T10662 det these,correlations
R2933 T10662 T10660 pobj correlations,from
R2934 T10663 T10662 nummod "23,574",correlations
R2935 T10664 T10653 auxpass is,shown
R2936 T10665 T10653 prep in,shown
R2937 T10666 T10667 compound Figure,5A
R2938 T10667 T10665 pobj 5A,in
R2939 T10668 T10653 punct .,shown
R2940 T10670 T10671 prep At,correlated
R2941 T10672 T10673 nsubj FDR,0.01
R2942 T10673 T10670 pcomp 0.01,At
R2943 T10674 T10673 punct =,0.01
R2944 T10675 T10671 punct ", ",correlated
R2945 T10676 T10677 nummod "4,613",genes
R2946 T10677 T10671 nsubjpass genes,correlated
R2947 T10678 T10671 auxpass were,correlated
R2948 T10679 T10671 advmod significantly,correlated
R2949 T10680 T10671 prep with,correlated
R2950 T10681 T10682 amod gonadal,mass
R2951 T10682 T10680 pobj mass,with
R2952 T10683 T10682 compound fat,mass
R2953 T10684 T10671 punct .,correlated
R2954 T10686 T10687 prep Of,showed
R2955 T10688 T10689 det these,genes
R2956 T10689 T10686 pobj genes,Of
R2957 T10690 T10687 punct ", ",showed
R2958 T10691 T10687 nsubj "4,524",showed
R2959 T10692 T10693 punct (,%
R2960 T10693 T10691 parataxis %,"4,524"
R2961 T10694 T10693 nummod 98,%
R2962 T10695 T10693 punct ),%
R2963 T10696 T10697 amod significant,effects
R2964 T10697 T10687 dobj effects,showed
R2965 T10698 T10697 punct “,effects
R2966 T10699 T10697 nmod gene,effects
R2967 T10700 T10699 punct -,gene
R2968 T10701 T10699 prep by,gene
R2969 T10702 T10701 punct -,by
R2970 T10703 T10701 pobj sex,by
R2971 T10704 T10697 punct ”,effects
R2972 T10705 T10687 punct ", ",showed
R2973 T10706 T10687 advcl supporting,showed
R2974 T10707 T10708 det the,degree
R2975 T10708 T10706 dobj degree,supporting
R2976 T10709 T10708 amod high,degree
R2977 T10710 T10708 prep of,degree
R2978 T10711 T10712 compound sex,specificity
R2979 T10712 T10710 pobj specificity,of
R2980 T10713 T10708 prep in,degree
R2981 T10714 T10715 det the,regulation
R2982 T10715 T10713 pobj regulation,in
R2983 T10716 T10715 amod genetic,regulation
R2984 T10717 T10715 prep of,regulation
R2985 T10718 T10719 det this,trait
R2986 T10719 T10717 pobj trait,of
R2987 T10720 T10687 punct .,showed
R2988 T10722 T10723 det A,list
R2989 T10723 T10725 nsubjpass list,provided
R2990 T10724 T10723 amod complete,list
R2991 T10726 T10723 prep of,list
R2992 T10727 T10728 det all,genes
R2993 T10728 T10726 pobj genes,of
R2994 T10729 T10728 acl correlated,genes
R2995 T10730 T10729 prep with,correlated
R2996 T10731 T10732 amod gonadal,mass
R2997 T10732 T10730 pobj mass,with
R2998 T10733 T10732 compound fat,mass
R2999 T10734 T10725 auxpass is,provided
R3000 T10735 T10725 prep in,provided
R3001 T10736 T10737 compound Table,S2
R3002 T10737 T10735 pobj S2,in
R3003 T10738 T10725 punct .,provided
R3004 T10740 T10741 prep Of,generate
R3005 T10742 T10743 det the,genes
R3006 T10743 T10740 pobj genes,Of
R3007 T10744 T10743 nummod "4,613",genes
R3008 T10745 T10743 acl correlated,genes
R3009 T10746 T10745 prep with,correlated
R3010 T10747 T10748 amod gonadal,mass
R3011 T10748 T10746 pobj mass,with
R3012 T10749 T10748 compound fat,mass
R3013 T10750 T10741 punct ", ",generate
R3014 T10751 T10741 nsubj "1,130",generate
R3015 T10752 T10753 nummod "1,478",eQTLs
R3016 T10753 T10741 dobj eQTLs,generate
R3017 T10754 T10753 amod significant,eQTLs
R3018 T10755 T10756 punct (,5B
R3019 T10756 T10741 parataxis 5B,generate
R3020 T10757 T10756 compound Figure,5B
R3021 T10758 T10756 punct ),5B
R3022 T10759 T10741 punct .,generate
R3023 T10761 T10762 det The,colocalization
R3024 T10762 T10763 nsubj colocalization,provides
R3025 T10764 T10762 prep of,colocalization
R3026 T10765 T10764 pobj eQTLs,of
R3027 T10766 T10765 prep for,eQTLs
R3028 T10767 T10768 det these,genes
R3029 T10768 T10766 pobj genes,for
R3030 T10769 T10768 amod correlated,genes
R3031 T10770 T10762 prep with,colocalization
R3032 T10771 T10772 det the,cQTL
R3033 T10772 T10770 pobj cQTL,with
R3034 T10773 T10772 prep for,cQTL
R3035 T10774 T10775 det the,trait
R3036 T10775 T10773 pobj trait,for
R3037 T10776 T10777 compound fat,mass
R3038 T10777 T10775 compound mass,trait
R3039 T10778 T10779 amod useful,implications
R3040 T10779 T10763 dobj implications,provides
R3041 T10780 T10779 prep for,implications
R3042 T10781 T10782 det the,role
R3043 T10782 T10780 pobj role,for
R3044 T10783 T10782 amod possible,role
R3045 T10784 T10782 prep of,role
R3046 T10785 T10786 det these,genes
R3047 T10786 T10784 pobj genes,of
R3048 T10787 T10763 punct .,provides
R3049 T10789 T10790 mark Whether,are
R3050 T10790 T10793 csubj are,determines
R3051 T10791 T10792 det the,eQTLs
R3052 T10792 T10790 nsubj eQTLs,are
R3053 T10794 T10790 attr cis,are
R3054 T10795 T10794 cc or,cis
R3055 T10796 T10794 conj trans,cis
R3056 T10797 T10798 dep what,be
R3057 T10798 T10793 ccomp be,determines
R3058 T10799 T10800 det that,role
R3059 T10800 T10798 nsubj role,be
R3060 T10801 T10798 aux may,be
R3061 T10802 T10793 punct .,determines
R3062 T10804 T10805 nsubj Genes,are
R3063 T10806 T10807 dep that,show
R3064 T10807 T10804 advcl show,Genes
R3065 T10808 T10809 amod significant,correlation
R3066 T10809 T10807 dobj correlation,show
R3067 T10810 T10809 prep with,correlation
R3068 T10811 T10812 det the,trait
R3069 T10812 T10810 pobj trait,with
R3070 T10813 T10814 amod gonadal,mass
R3071 T10814 T10812 compound mass,trait
R3072 T10815 T10814 compound fat,mass
R3073 T10816 T10807 cc and,show
R3074 T10817 T10818 dep that,have
R3075 T10818 T10807 conj have,show
R3076 T10819 T10820 compound cis,eQTLs
R3077 T10820 T10818 dobj eQTLs,have
R3078 T10821 T10820 punct -,eQTLs
R3079 T10822 T10820 amod coincident,eQTLs
R3080 T10823 T10822 prep with,coincident
R3081 T10824 T10825 det the,cQTLs
R3082 T10825 T10823 pobj cQTLs,with
R3083 T10826 T10827 compound fat,mass
R3084 T10827 T10825 compound mass,cQTLs
R3085 T10828 T10829 amod potential,genes
R3086 T10829 T10805 attr genes,are
R3087 T10830 T10829 compound candidate,genes
R3088 T10831 T10829 prep for,genes
R3089 T10832 T10833 det the,trait
R3090 T10833 T10831 pobj trait,for
R3091 T10834 T10835 punct (,contain
R3092 T10835 T10805 parataxis contain,are
R3093 T10836 T10835 advmod i.e.,contain
R3094 T10837 T10835 punct ", ",contain
R3095 T10838 T10835 nsubj they,contain
R3096 T10839 T10835 aux may,contain
R3097 T10840 T10841 det a,variation
R3098 T10841 T10835 dobj variation,contain
R3099 T10842 T10841 amod genetic,variation
R3100 T10843 T10835 prep in,contain
R3101 T10844 T10845 det that,gene
R3102 T10845 T10843 pobj gene,in
R3103 T10846 T10847 dep that,is
R3104 T10847 T10845 relcl is,gene
R3105 T10848 T10849 det the,cause
R3106 T10849 T10847 attr cause,is
R3107 T10850 T10849 prep of,cause
R3108 T10851 T10852 det the,cQTL
R3109 T10852 T10850 pobj cQTL,of
R3110 T10853 T10852 compound trait,cQTL
R3111 T10854 T10835 punct ),contain
R3112 T10855 T10805 punct .,are
R3113 T10857 T10858 nsubj Table,summarizes
R3114 T10859 T10857 nummod 5,Table
R3115 T10860 T10861 det the,genes
R3116 T10861 T10858 dobj genes,summarizes
R3117 T10862 T10863 dep that,possess
R3118 T10863 T10861 relcl possess,genes
R3119 T10864 T10865 det these,properties
R3120 T10865 T10863 dobj properties,possess
R3121 T10866 T10865 prep for,properties
R3122 T10867 T10868 det each,cQTL
R3123 T10868 T10866 pobj cQTL,for
R3124 T10869 T10863 punct ", ",possess
R3125 T10870 T10871 amod increasing,evidence
R3126 T10871 T10863 npadvmod evidence,possess
R3127 T10872 T10871 prep for,evidence
R3128 T10873 T10874 det these,genes
R3129 T10874 T10872 pobj genes,for
R3130 T10875 T10874 prep as,genes
R3131 T10876 T10877 amod potential,candidates
R3132 T10877 T10875 pobj candidates,as
R3133 T10878 T10858 punct .,summarizes
R3134 T10880 T10881 mark As,addressed
R3135 T10881 T10882 advcl addressed,is
R3136 T10883 T10881 advmod below,addressed
R3137 T10884 T10882 punct ", ",is
R3138 T10885 T10882 prep given,is
R3139 T10886 T10887 det the,regulation
R3140 T10887 T10885 pobj regulation,given
R3141 T10888 T10887 amod complex,regulation
R3142 T10889 T10887 compound multiorgan,regulation
R3143 T10890 T10887 prep of,regulation
R3144 T10891 T10892 compound adipose,tissue
R3145 T10892 T10893 compound tissue,mass
R3146 T10893 T10890 pobj mass,of
R3147 T10894 T10882 punct ", ",is
R3148 T10895 T10882 nsubj it,is
R3149 T10896 T10882 acomp unlikely,is
R3150 T10897 T10898 mark that,resides
R3151 T10898 T10882 ccomp resides,is
R3152 T10899 T10900 det the,regulation
R3153 T10900 T10898 nsubj regulation,resides
R3154 T10901 T10900 amod genetic,regulation
R3155 T10902 T10900 prep of,regulation
R3156 T10903 T10904 det all,loci
R3157 T10904 T10902 pobj loci,of
R3158 T10905 T10904 nummod five,loci
R3159 T10906 T10898 prep in,resides
R3160 T10907 T10908 det the,liver
R3161 T10908 T10906 pobj liver,in
R3162 T10909 T10882 punct .,is
R3163 T10911 T10912 advmod However,involve
R3164 T10913 T10912 punct ", ",involve
R3165 T10914 T10912 nsubj some,involve
R3166 T10915 T10912 aux may,involve
R3167 T10916 T10917 det the,liver
R3168 T10917 T10912 dobj liver,involve
R3169 T10918 T10912 punct ", ",involve
R3170 T10919 T10912 cc and,involve
R3171 T10920 T10921 advmod even,for
R3172 T10921 T10922 prep for,reflect
R3173 T10922 T10912 conj reflect,involve
R3174 T10923 T10921 pobj those,for
R3175 T10924 T10925 dep that,not
R3176 T10925 T10923 relcl not,those
R3177 T10926 T10925 aux do,not
R3178 T10927 T10922 punct ", ",reflect
R3179 T10928 T10929 det the,variation
R3180 T10929 T10922 nsubj variation,reflect
R3181 T10930 T10929 nmod liver,variation
R3182 T10931 T10929 amod transcriptional,variation
R3183 T10932 T10922 aux may,reflect
R3184 T10933 T10922 dobj that,reflect
R3185 T10934 T10933 prep of,that
R3186 T10935 T10936 det the,tissue
R3187 T10936 T10934 pobj tissue,of
R3188 T10937 T10936 amod relevant,tissue
R3189 T10938 T10912 punct .,involve
R3190 T10940 T10941 nsubj Genes,be
R3191 T10942 T10943 dep that,show
R3192 T10943 T10940 relcl show,Genes
R3193 T10944 T10945 amod significant,correlation
R3194 T10945 T10943 dobj correlation,show
R3195 T10946 T10945 prep with,correlation
R3196 T10947 T10948 amod gonadal,mass
R3197 T10948 T10946 pobj mass,with
R3198 T10949 T10948 compound fat,mass
R3199 T10950 T10943 cc and,show
R3200 T10951 T10943 conj have,show
R3201 T10952 T10953 compound trans,eQTLs
R3202 T10953 T10951 dobj eQTLs,have
R3203 T10954 T10953 punct -,eQTLs
R3204 T10955 T10953 amod coincident,eQTLs
R3205 T10956 T10955 prep with,coincident
R3206 T10957 T10958 det the,cQTL
R3207 T10958 T10956 pobj cQTL,with
R3208 T10959 T10960 compound fat,mass
R3209 T10960 T10958 compound mass,cQTL
R3210 T10961 T10941 aux can,be
R3211 T10962 T10941 neg not,be
R3212 T10963 T10941 attr candidates,be
R3213 T10964 T10965 advmod directly,responsible
R3214 T10965 T10963 amod responsible,candidates
R3215 T10966 T10965 prep for,responsible
R3216 T10967 T10968 det the,trait
R3217 T10968 T10966 pobj trait,for
R3218 T10969 T10941 punct ", ",be
R3219 T10970 T10971 mark as,located
R3220 T10971 T10941 advcl located,be
R3221 T10972 T10971 nsubjpass they,located
R3222 T10973 T10971 auxpass are,located
R3223 T10974 T10971 advmod physically,located
R3224 T10975 T10971 advmod elsewhere,located
R3225 T10976 T10975 prep in,elsewhere
R3226 T10977 T10978 det the,genome
R3227 T10978 T10976 pobj genome,in
R3228 T10979 T10941 punct .,be
R3229 T10981 T10982 advmod However,involved
R3230 T10983 T10982 punct ", ",involved
R3231 T10984 T10982 nsubjpass they,involved
R3232 T10985 T10982 auxpass are,involved
R3233 T10986 T10982 advmod potentially,involved
R3234 T10987 T10982 prep in,involved
R3235 T10988 T10989 det the,pathway
R3236 T10989 T10987 pobj pathway,in
R3237 T10990 T10989 punct (,pathway
R3238 T10991 T10989 nmod s,pathway
R3239 T10992 T10989 punct ),pathway
R3240 T10993 T10989 acl leading,pathway
R3241 T10994 T10993 prep from,leading
R3242 T10995 T10996 det the,gene
R3243 T10996 T10994 pobj gene,from
R3244 T10997 T10996 amod causative,gene
R3245 T10998 T10993 prep to,leading
R3246 T10999 T11000 det the,expression
R3247 T11000 T10998 pobj expression,to
R3248 T11001 T11000 prep of,expression
R3249 T11002 T11003 det the,trait
R3250 T11003 T11001 pobj trait,of
R3251 T11004 T11005 compound fat,mass
R3252 T11005 T11003 compound mass,trait
R3253 T11006 T11007 punct (,regulated
R3254 T11007 T10982 parataxis regulated,involved
R3255 T11008 T11007 advmod i.e.,regulated
R3256 T11009 T11007 punct ", ",regulated
R3257 T11010 T11011 poss their,transcription
R3258 T11011 T11007 nsubjpass transcription,regulated
R3259 T11012 T11007 auxpass is,regulated
R3260 T11013 T11007 advmod closely,regulated
R3261 T11014 T11007 agent by,regulated
R3262 T11015 T11016 det the,gene
R3263 T11016 T11014 pobj gene,by
R3264 T11017 T11016 amod causative,gene
R3265 T11018 T11007 prep at,regulated
R3266 T11019 T11020 det the,locus
R3267 T11020 T11018 pobj locus,at
R3268 T11021 T11007 punct ),regulated
R3269 T11022 T10982 punct .,involved
R3270 T11024 T11025 nsubj All,have
R3271 T11026 T11024 prep of,All
R3272 T11027 T11028 det the,cQTLs
R3273 T11028 T11026 pobj cQTLs,of
R3274 T11029 T11028 nummod five,cQTLs
R3275 T11030 T11031 compound fat,mass
R3276 T11031 T11028 compound mass,cQTLs
R3277 T11032 T11033 amod colocalizing,eQTLs
R3278 T11033 T11025 dobj eQTLs,have
R3279 T11034 T11033 compound trans,eQTLs
R3280 T11035 T11033 punct -,eQTLs
R3281 T11036 T11033 prep for,eQTLs
R3282 T11037 T11038 amod correlated,genes
R3283 T11038 T11036 pobj genes,for
R3284 T11039 T11025 punct .,have
R3285 T11041 T11042 advmod However,is
R3286 T11043 T11042 punct ", ",is
R3287 T11044 T11042 prep for,is
R3288 T11045 T11046 det a,trait
R3289 T11046 T11044 pobj trait,for
R3290 T11047 T11048 amod such,as
R3291 T11048 T11046 prep as,trait
R3292 T11049 T11050 compound fat,mass
R3293 T11050 T11048 pobj mass,as
R3294 T11051 T11052 dep that,regulated
R3295 T11052 T11046 relcl regulated,trait
R3296 T11053 T11052 auxpass is,regulated
R3297 T11054 T11052 agent by,regulated
R3298 T11055 T11056 amod multiple,tissues
R3299 T11056 T11054 pobj tissues,by
R3300 T11057 T11056 cc and,tissues
R3301 T11058 T11056 conj organs,tissues
R3302 T11059 T11042 punct ", ",is
R3303 T11060 T11042 nsubj it,is
R3304 T11061 T11042 acomp unlikely,is
R3305 T11062 T11063 mark that,driven
R3306 T11063 T11042 ccomp driven,is
R3307 T11064 T11065 det all,cQTLs
R3308 T11065 T11063 nsubjpass cQTLs,driven
R3309 T11066 T11065 nummod five,cQTLs
R3310 T11067 T11068 compound fat,mass
R3311 T11068 T11065 compound mass,cQTLs
R3312 T11069 T11063 auxpass are,driven
R3313 T11070 T11063 advmod primarily,driven
R3314 T11071 T11063 agent by,driven
R3315 T11072 T11073 compound liver,expression
R3316 T11073 T11071 pobj expression,by
R3317 T11074 T11073 compound gene,expression
R3318 T11075 T11042 punct .,is
R3319 T11077 T11078 prep As,hypothesized
R3320 T11079 T11080 det an,approach
R3321 T11080 T11077 pobj approach,As
R3322 T11081 T11080 prep to,approach
R3323 T11082 T11083 det this,problem
R3324 T11083 T11081 pobj problem,to
R3325 T11084 T11078 punct ", ",hypothesized
R3326 T11085 T11078 nsubj we,hypothesized
R3327 T11086 T11087 mark that,show
R3328 T11087 T11078 ccomp show,hypothesized
R3329 T11088 T11089 det those,cQTLs
R3330 T11089 T11087 nsubj cQTLs,show
R3331 T11090 T11091 dep that,associated
R3332 T11091 T11089 relcl associated,cQTLs
R3333 T11092 T11091 auxpass are,associated
R3334 T11093 T11094 advmod most,closely
R3335 T11094 T11091 advmod closely,associated
R3336 T11095 T11091 prep with,associated
R3337 T11096 T11097 compound liver,expression
R3338 T11097 T11095 pobj expression,with
R3339 T11098 T11097 compound gene,expression
R3340 T11099 T11087 aux would,show
R3341 T11100 T11101 det an,overrepresentation
R3342 T11101 T11087 dobj overrepresentation,show
R3343 T11102 T11101 prep of,overrepresentation
R3344 T11103 T11104 amod colocalized,eQTL
R3345 T11104 T11102 pobj eQTL,of
R3346 T11105 T11101 prep for,overrepresentation
R3347 T11106 T11107 amod correlated,genes
R3348 T11107 T11105 pobj genes,for
R3349 T11108 T11087 punct ", ",show
R3350 T11109 T11110 mark while,shown
R3351 T11110 T11087 advcl shown,show
R3352 T11111 T11112 det those,loci
R3353 T11112 T11110 nsubj loci,shown
R3354 T11113 T11114 advmod primarily,controlled
R3355 T11114 T11112 acl controlled,loci
R3356 T11115 T11114 agent by,controlled
R3357 T11116 T11117 amod other,tissues
R3358 T11117 T11115 pobj tissues,by
R3359 T11118 T11110 aux would,shown
R3360 T11119 T11110 neg not,shown
R3361 T11120 T11110 aux have,shown
R3362 T11121 T11122 det this,pattern
R3363 T11122 T11110 dobj pattern,shown
R3364 T11123 T11078 punct .,hypothesized
R3365 T11125 T11126 aux To,assess
R3366 T11126 T11127 advcl assess,determined
R3367 T11128 T11126 dobj this,assess
R3368 T11129 T11127 punct ", ",determined
R3369 T11130 T11127 nsubj we,determined
R3370 T11131 T11127 advmod first,determined
R3371 T11132 T11133 det the,distribution
R3372 T11133 T11127 dobj distribution,determined
R3373 T11134 T11133 prep of,distribution
R3374 T11135 T11136 det these,eQTLs
R3375 T11136 T11134 pobj eQTLs,of
R3376 T11137 T11136 nummod "1,478",eQTLs
R3377 T11138 T11133 prep across,distribution
R3378 T11139 T11140 det the,genome
R3379 T11140 T11138 pobj genome,across
R3380 T11141 T11127 prep in,determined
R3381 T11142 T11143 nummod 2,cM
R3382 T11143 T11145 compound cM,bins
R3383 T11144 T11143 punct -,cM
R3384 T11145 T11141 pobj bins,in
R3385 T11146 T11147 mark as,shown
R3386 T11147 T11127 advcl shown,determined
R3387 T11148 T11147 prep in,shown
R3388 T11149 T11150 compound Figure,5C
R3389 T11150 T11148 pobj 5C,in
R3390 T11151 T11127 punct .,determined
R3391 T11153 T11154 prep In,tested
R3392 T11155 T11153 pobj order,In
R3393 T11156 T11157 aux to,see
R3394 T11157 T11155 acl see,order
R3395 T11158 T11159 mark if,exist
R3396 T11159 T11157 ccomp exist,see
R3397 T11160 T11159 expl there,exist
R3398 T11161 T11162 det any,hotspots
R3399 T11162 T11159 dobj hotspots,exist
R3400 T11163 T11162 prep for,hotspots
R3401 T11164 T11165 det these,eQTLs
R3402 T11165 T11163 pobj eQTLs,for
R3403 T11166 T11154 punct ", ",tested
R3404 T11167 T11154 nsubj we,tested
R3405 T11168 T11154 dobj eQTLs,tested
R3406 T11169 T11168 prep with,eQTLs
R3407 T11170 T11169 pobj p,with
R3408 T11171 T11172 punct <,0.001
R3409 T11172 T11170 amod 0.001,p
R3410 T11173 T11154 prep for,tested
R3411 T11174 T11173 pobj enrichment,for
R3412 T11175 T11174 prep along,enrichment
R3413 T11176 T11177 det the,genome
R3414 T11177 T11175 pobj genome,along
R3415 T11178 T11154 prep in,tested
R3416 T11179 T11180 amod overlapping,bins
R3417 T11180 T11178 pobj bins,in
R3418 T11181 T11182 nummod 2,cM
R3419 T11182 T11180 compound cM,bins
R3420 T11183 T11182 punct -,cM
R3421 T11184 T11154 prep against,tested
R3422 T11185 T11186 det the,distribution
R3423 T11186 T11184 pobj distribution,against
R3424 T11187 T11186 prep of,distribution
R3425 T11188 T11189 det all,eQTLs
R3426 T11189 T11187 pobj eQTLs,of
R3427 T11196 T11197 det a,test
R3428 T11190 T11189 compound liver,eQTLs
R3429 T11197 T11195 dobj test,using
R3430 T11198 T11197 nmod Fisher,test
R3431 T11191 T11192 punct (,4A
R3432 T11199 T11197 amod exact,test
R3433 T11200 T11154 punct .,tested
R3434 T11192 T11189 parataxis 4A,eQTLs
R3435 T11202 T11203 compound Figure,5D
R3436 T11203 T11204 nsubj 5D,shows
R3437 T11193 T11192 compound Figure,4A
R3438 T11205 T11206 det the,significance
R3439 T11194 T11192 punct ),4A
R3440 T11206 T11204 dobj significance,shows
R3441 T11207 T11206 prep of,significance
R3442 T11208 T11207 pobj enrichment,of
R3443 T11195 T11154 advcl using,tested
R3444 T11209 T11206 acl reported,significance
R3445 T11210 T11209 prep as,reported
R3446 T11303 T11304 det The,effect
R3447 T11211 T11212 punct −,log10
R3448 T11212 T11210 pobj log10,as
R3449 T11213 T11212 prep of,log10
R3450 T11214 T11215 det the,value
R3451 T11304 T11305 nsubjpass effect,summarized
R3452 T11215 T11213 pobj value,of
R3453 T11216 T11215 compound enrichment,value
R3454 T11217 T11215 compound p,value
R3455 T11306 T11304 prep of,effect
R3456 T11218 T11215 punct -,value
R3457 T11219 T11209 prep across,reported
R3458 T11220 T11221 det the,genome
R3459 T11221 T11219 pobj genome,across
R3460 T11307 T11308 det the,eQTLs
R3461 T11222 T11204 punct .,shows
R3462 T11308 T11306 pobj eQTLs,of
R3463 T11224 T11225 nummod One,locus
R3464 T11225 T11226 nsubjpass locus,enriched
R3465 T11309 T11308 compound trans,eQTLs
R3466 T11227 T11225 prep on,locus
R3467 T11228 T11227 pobj Chromosome,on
R3468 T11229 T11228 nummod 19,Chromosome
R3469 T11310 T11308 punct -,eQTLs
R3470 T11230 T11226 auxpass was,enriched
R3471 T11231 T11226 advmod significantly,enriched
R3472 T11232 T11226 prep for,enriched
R3473 T11233 T11232 pobj eQTLs,for
R3474 T11311 T11308 prep at,eQTLs
R3475 T11312 T11313 det the,locus
R3476 T11313 T11311 pobj locus,at
R3477 T11234 T11233 prep of,eQTLs
R3478 T11314 T11313 nmod Chromosome,locus
R3479 T11235 T11234 pobj transcripts,of
R3480 T11236 T11235 acl correlated,transcripts
R3481 T11237 T11236 prep with,correlated
R3482 T11315 T11314 nummod 19,Chromosome
R3483 T11238 T11239 det the,trait
R3484 T11239 T11237 pobj trait,with
R3485 T11316 T11304 prep on,effect
R3486 T11240 T11241 amod gonadal,mass
R3487 T11241 T11239 compound mass,trait
R3488 T11242 T11241 compound fat,mass
R3489 T11243 T11226 punct .,enriched
R3490 T11317 T11318 compound gene,expression
R3491 T11245 T11246 mark As,anticipated
R3492 T11246 T11247 advcl anticipated,was
R3493 T11318 T11316 pobj expression,on
R3494 T11248 T11247 punct ", ",was
R3495 T11319 T11305 auxpass is,summarized
R3496 T11249 T11247 expl there,was
R3497 T11250 T11251 det an,overlap
R3498 T11320 T11305 prep in,summarized
R3499 T11321 T11320 pobj Figure,in
R3500 T11251 T11247 attr overlap,was
R3501 T11322 T11321 nummod 6,Figure
R3502 T11252 T11251 prep of,overlap
R3503 T11253 T11254 det a,hotspot
R3504 T11254 T11252 pobj hotspot,of
R3505 T11323 T11305 punct .,summarized
R3506 T11255 T11254 amod correlated,hotspot
R3507 T11256 T11254 compound eQTL,hotspot
R3508 T11257 T11254 cc and,hotspot
R3509 T11325 T11326 compound Twenty,nine
R3510 T11258 T11259 det a,cQTL
R3511 T11259 T11254 conj cQTL,hotspot
R3512 T11326 T11328 nummod nine,eQTLs
R3513 T11260 T11261 compound fat,mass
R3514 T11261 T11259 compound mass,cQTL
R3515 T11262 T11251 punct ", ",overlap
R3516 T11327 T11326 punct -,nine
R3517 T11263 T11264 advmod specifically,Chromosome
R3518 T11264 T11251 appos Chromosome,overlap
R3519 T11265 T11264 nummod 19,Chromosome
R3520 T11266 T11264 prep at,Chromosome
R3521 T11267 T11268 nummod 40,cM
R3522 T11268 T11266 pobj cM,at
R3523 T11328 T11331 nsubj eQTLs,colocalize
R3524 T11269 T11247 punct .,was
R3525 T11329 T11328 compound trans,eQTLs
R3526 T11271 T11272 nsubj This,suggests
R3527 T11330 T11328 punct -,eQTLs
R3528 T11273 T11274 mark that,tied
R3529 T11274 T11272 ccomp tied,suggests
R3530 T11275 T11276 det the,regulation
R3531 T11332 T11331 prep to,colocalize
R3532 T11276 T11274 nsubjpass regulation,tied
R3533 T11277 T11276 amod genetic,regulation
R3534 T11278 T11276 prep of,regulation
R3535 T11279 T11280 compound fat,mass
R3536 T11280 T11278 pobj mass,of
R3537 T11333 T11332 pobj Chromosome,to
R3538 T11281 T11276 prep for,regulation
R3539 T11282 T11283 det the,locus
R3540 T11334 T11333 nummod 9,Chromosome
R3541 T11283 T11281 pobj locus,for
R3542 T11284 T11283 nmod Chromosome,locus
R3543 T11285 T11284 nummod 19,Chromosome
R3544 T11335 T11331 prep at,colocalize
R3545 T11286 T11274 auxpass is,tied
R3546 T11287 T11288 advmod more,closely
R3547 T11288 T11274 advmod closely,tied
R3548 T11336 T11337 nummod 40,cM
R3549 T11289 T11274 prep to,tied
R3550 T11290 T11291 compound liver,expression
R3551 T11291 T11289 pobj expression,to
R3552 T11337 T11335 pobj cM,at
R3553 T11292 T11291 compound gene,expression
R3554 T11293 T11294 mark than,are
R3555 T11294 T11274 advcl are,tied
R3556 T11295 T11296 det the,cQTLs
R3557 T11296 T11294 nsubj cQTLs,are
R3558 T11338 T11331 punct ", ",colocalize
R3559 T11297 T11296 amod other,cQTLs
R3560 T11298 T11296 nummod four,cQTLs
R3561 T11299 T11300 compound fat,mass
R3562 T11339 T11331 advcl suggesting,colocalize
R3563 T11300 T11296 compound mass,cQTLs
R3564 T11301 T11272 punct .,suggests
R3565 T11340 T11341 mark that,regulated
R3566 T11341 T11339 ccomp regulated,suggesting
R3567 T11342 T11343 nummod 29,genes
R3568 T11408 T11409 amod greater,regulation
R3569 T11343 T11341 nsubjpass genes,regulated
R3570 T11409 T11399 dobj regulation,demonstrated
R3571 T11410 T11409 amod genetic,regulation
R3572 T11411 T11409 prep of,regulation
R3573 T11412 T11413 compound gene,expression
R3574 T11413 T11411 pobj expression,of
R3575 T11344 T11343 acl correlated,genes
R3576 T11414 T11409 prep than,regulation
R3577 T11415 T11414 pobj males,than
R3578 T11416 T11399 punct .,demonstrated
R3579 T11345 T11344 prep with,correlated
R3580 T11418 T11419 det This,bias
R3581 T11346 T11347 amod gonadal,mass
R3582 T11347 T11345 pobj mass,with
R3583 T11348 T11347 compound fat,mass
R3584 T11349 T11341 auxpass are,regulated
R3585 T11419 T11422 nsubj bias,is
R3586 T11350 T11341 prep in,regulated
R3587 T11420 T11419 amod substantial,bias
R3588 T11421 T11419 amod female,bias
R3589 T11351 T11350 pobj trans,in
R3590 T11423 T11424 advmod significantly,higher
R3591 T11424 T11422 acomp higher,is
R3592 T11425 T11426 mark than,expected
R3593 T11352 T11341 agent by,regulated
R3594 T11426 T11424 advcl expected,higher
R3595 T11427 T11426 aux would,expected
R3596 T11428 T11426 auxpass be,expected
R3597 T11353 T11354 det a,polymorphism
R3598 T11429 T11430 aux to,arise
R3599 T11354 T11352 pobj polymorphism,by
R3600 T11430 T11426 xcomp arise,expected
R3601 T11431 T11430 prep by,arise
R3602 T11432 T11431 pobj chance,by
R3603 T11355 T11354 prep at,polymorphism
R3604 T11433 T11430 prep for,arise
R3605 T11434 T11435 det the,locus
R3606 T11435 T11433 pobj locus,for
R3607 T11356 T11357 det this,position
R3608 T11436 T11435 nmod Chromosome,locus
R3609 T11437 T11436 nummod 19,Chromosome
R3610 T11438 T11439 punct (,0.001
R3611 T11357 T11355 pobj position,at
R3612 T11439 T11430 parataxis 0.001,arise
R3613 T11440 T11439 nsubj p,0.001
R3614 T11441 T11439 punct <,0.001
R3615 T11358 T11331 punct .,colocalize
R3616 T11442 T11439 prep by,0.001
R3617 T11443 T11442 pobj χ2,by
R3618 T11444 T11439 punct ),0.001
R3619 T11360 T11361 det The,proportion
R3620 T11445 T11422 punct .,is
R3621 T11447 T11448 det This,locus
R3622 T11448 T11449 nsubj locus,corresponds
R3623 T11361 T11362 nsubj proportion,differs
R3624 T11450 T11449 prep to,corresponds
R3625 T11451 T11450 pobj one,to
R3626 T11452 T11451 prep of,one
R3627 T11453 T11454 det the,cQTLs
R3628 T11454 T11452 pobj cQTLs,of
R3629 T11363 T11361 prep of,proportion
R3630 T11455 T11454 nummod four,cQTLs
R3631 T11456 T11457 npadvmod sex,biased
R3632 T11457 T11454 amod biased,cQTLs
R3633 T11458 T11457 punct -,biased
R3634 T11364 T11365 compound gene,expression
R3635 T11459 T11454 prep for,cQTLs
R3636 T11460 T11461 amod gonadal,mass
R3637 T11365 T11366 compound expression,levels
R3638 T11461 T11459 pobj mass,for
R3639 T11462 T11461 compound fat,mass
R3640 T11463 T11454 acl reported,cQTLs
R3641 T11366 T11363 pobj levels,of
R3642 T11464 T11463 prep in,reported
R3643 T11465 T11466 det this,study
R3644 T11466 T11464 pobj study,in
R3645 T11367 T11366 acl controlled,levels
R3646 T11467 T11449 punct ", ",corresponds
R3647 T11468 T11449 cc and,corresponds
R3648 T11469 T11470 det the,specificity
R3649 T11368 T11367 agent by,controlled
R3650 T11470 T11473 nsubj specificity,supports
R3651 T11471 T11470 amod significant,specificity
R3652 T11472 T11470 compound sex,specificity
R3653 T11369 T11370 det this,locus
R3654 T11473 T11449 conj supports,corresponds
R3655 T11474 T11470 prep of,specificity
R3656 T11370 T11368 pobj locus,by
R3657 T11475 T11476 preconj both,cis
R3658 T11476 T11478 nmod cis,regulation
R3659 T11477 T11476 det the,cis
R3660 T11371 T11366 punct (,levels
R3661 T11478 T11474 pobj regulation,of
R3662 T11479 T11476 cc and,cis
R3663 T11372 T11366 acl approximated,levels
R3664 T11480 T11476 conj trans,cis
R3665 T11481 T11478 amod genetic,regulation
R3666 T11482 T11478 prep of,regulation
R3667 T11373 T11372 prep as,approximated
R3668 T11483 T11484 compound liver,genes
R3669 T11484 T11482 pobj genes,of
R3670 T11485 T11484 acl correlated,genes
R3671 T11374 T11375 det the,coefficients
R3672 T11486 T11485 prep with,correlated
R3673 T11487 T11488 compound fat,mass
R3674 T11488 T11486 pobj mass,with
R3675 T11375 T11373 pobj coefficients,as
R3676 T11489 T11490 det the,significance
R3677 T11490 T11473 dobj significance,supports
R3678 T11491 T11490 amod functional,significance
R3679 T11492 T11490 prep of,significance
R3680 T11493 T11494 det this,locus
R3681 T11494 T11492 pobj locus,of
R3682 T11376 T11375 prep of,coefficients
R3683 T11495 T11490 prep in,significance
R3684 T11496 T11497 det this,organ
R3685 T11497 T11495 pobj organ,in
R3686 T11377 T11378 compound determination,R 2
R3687 T11498 T11473 punct .,supports
R3688 T11378 T11376 pobj R 2,of
R3689 T11379 T11362 punct ),differs
R3690 T11380 T11362 prep between,differs
R3691 T11381 T11380 pobj males,between
R3692 T11382 T11381 cc and,males
R3693 T11383 T11381 conj females,males
R3694 T11384 T11362 prep for,differs
R3695 T11385 T11386 det the,majority
R3696 T11386 T11384 pobj majority,for
R3697 T11387 T11386 prep of,majority
R3698 T11388 T11389 det the,transcripts
R3699 T11389 T11387 pobj transcripts,of
R3700 T11390 T11391 punct (,as
R3701 T11391 T11362 parataxis as,differs
R3702 T11392 T11391 prep in,as
R3703 T11393 T11394 compound Figure,6A
R3704 T11394 T11392 pobj 6A,in
R3705 T11395 T11391 punct ),as
R3706 T11396 T11362 punct ", ",differs
R3707 T11397 T11362 cc and,differs
R3708 T11398 T11399 prep for,demonstrated
R3709 T11399 T11362 conj demonstrated,differs
R3710 T11400 T11398 pobj Chromosome,for
R3711 T11401 T11400 nummod 19,Chromosome
R3712 T11402 T11403 punct (,6B
R3713 T11403 T11400 parataxis 6B,Chromosome
R3714 T11404 T11403 compound Figure,6B
R3715 T11405 T11403 punct ),6B
R3716 T11406 T11399 punct ", ",demonstrated
R3717 T11407 T11399 nsubj females,demonstrated
R3718 T11696 T11697 prep In,described
R3719 T11698 T11699 det this,study
R3720 T11699 T11696 pobj study,In
R3721 T11700 T11697 punct ", ",described
R3722 T11701 T11697 nsubj we,described
R3723 T11702 T11703 det a,population
R3724 T11703 T11697 dobj population,described
R3725 T11704 T11703 amod large,population
R3726 T11705 T11703 punct ", ",population
R3727 T11706 T11707 advmod densely,mapped
R3728 T11707 T11703 amod mapped,population
R3729 T11708 T11703 punct ", ",population
R3730 T11709 T11703 amod segregating,population
R3731 T11710 T11703 compound F2,population
R3732 T11711 T11703 compound mouse,population
R3733 T11712 T11703 acl designed,population
R3734 T11713 T11714 aux to,study
R3735 T11714 T11712 advcl study,designed
R3736 T11715 T11716 det the,regulation
R3737 T11716 T11714 dobj regulation,study
R3738 T11717 T11716 amod genetic,regulation
R3739 T11718 T11716 prep of,regulation
R3740 T11719 T11720 amod several,traits
R3741 T11720 T11718 pobj traits,of
R3742 T11721 T11720 acl associated,traits
R3743 T11722 T11721 prep with,associated
R3744 T11723 T11724 det the,syndrome
R3745 T11724 T11722 pobj syndrome,with
R3746 T11725 T11726 advmod so,called
R3747 T11726 T11724 amod called,syndrome
R3748 T11727 T11726 punct -,called
R3749 T11728 T11724 amod metabolic,syndrome
R3750 T11729 T11697 punct .,described
R3751 T11731 T11732 amod Several,groups
R3752 T11732 T11733 nsubj groups,reported
R3753 T11734 T11732 punct ", ",groups
R3754 T11735 T11732 prep including,groups
R3755 T11736 T11735 pobj ours,including
R3756 T11737 T11733 punct ", ",reported
R3757 T11738 T11733 aux have,reported
R3758 T11739 T11740 det the,advantage
R3759 T11740 T11733 dobj advantage,reported
R3760 T11741 T11740 prep of,advantage
R3761 T11742 T11741 pcomp combining,of
R3762 T11743 T11744 amod traditional,genetics
R3763 T11744 T11742 dobj genetics,combining
R3764 T11745 T11742 prep with,combining
R3765 T11746 T11747 npadvmod genome,wide
R3766 T11747 T11749 amod wide,analysis
R3767 T11748 T11747 punct -,wide
R3768 T11749 T11745 pobj analysis,with
R3769 T11750 T11751 compound gene,expression
R3770 T11751 T11749 compound expression,analysis
R3771 T11752 T11742 prep for,combining
R3772 T11753 T11754 det the,dissection
R3773 T11754 T11752 pobj dissection,for
R3774 T11755 T11754 prep of,dissection
R3775 T11756 T11757 amod complex,traits
R3776 T11757 T11755 pobj traits,of
R3777 T11758 T11733 punct .,reported
R3778 T11760 T11761 det This,study
R3779 T11761 T11762 nsubj study,improved
R3780 T11763 T11762 prep on,improved
R3781 T11764 T11765 amod past,models
R3782 T11765 T11763 pobj models,on
R3783 T11766 T11762 prep by,improved
R3784 T11767 T11766 pcomp including,by
R3785 T11768 T11769 quantmod over,300
R3786 T11769 T11770 nummod 300,animals
R3787 T11770 T11767 dobj animals,including
R3788 T11771 T11772 punct (,size
R3789 T11772 T11770 parataxis size,animals
R3790 T11773 T11772 nummod three,size
R3791 T11774 T11773 quantmod times,three
R3792 T11775 T11772 det the,size
R3793 T11776 T11772 prep of,size
R3794 T11777 T11778 amod previous,studies
R3795 T11778 T11776 pobj studies,of
R3796 T11779 T11772 punct ),size
R3797 T11780 T11770 prep of,animals
R3798 T11781 T11782 det both,sexes
R3799 T11782 T11780 pobj sexes,of
R3800 T11783 T11767 punct ", ",including
R3801 T11784 T11767 advcl allowing,including
R3802 T11785 T11784 prep for,allowing
R3803 T11786 T11787 det the,incorporation
R3804 T11787 T11785 pobj incorporation,for
R3805 T11788 T11787 prep of,incorporation
R3806 T11789 T11790 npadvmod sex,specific
R3807 T11790 T11792 amod specific,effects
R3808 T11791 T11790 punct -,specific
R3809 T11792 T11788 pobj effects,of
R3810 T11793 T11792 prep on,effects
R3811 T11794 T11795 amod underlying,regulation
R3812 T11795 T11793 pobj regulation,on
R3813 T11796 T11795 amod genetic,regulation
R3814 T11797 T11762 punct .,improved
R3817 T13776 T13777 amod Significant,Bias
R3818 T13778 T13777 compound Sex,Bias
R3819 T13779 T13777 prep in,Bias
R3820 T13780 T13781 det the,Regulation
R3821 T13781 T13779 pobj Regulation,in
R3822 T13782 T13781 prep of,Regulation
R3823 T13783 T13784 preconj Both,Traits
R3824 T13784 T13782 pobj Traits,of
R3825 T13785 T13784 amod Complex,Traits
R3826 T13786 T13784 cc and,Traits
R3827 T13787 T13788 compound Gene,Expression
R3828 T13788 T13784 conj Expression,Traits
R3829 T13790 T13791 prep Given,designed
R3830 T13792 T13793 det the,dichotomy
R3831 T13793 T13790 pobj dichotomy,Given
R3832 T13794 T13793 amod known,dichotomy
R3833 T13795 T13793 prep between,dichotomy
R3834 T13796 T13795 pobj females,between
R3835 T13797 T13796 cc and,females
R3836 T13798 T13796 conj males,females
R3837 T13799 T13793 prep in,dichotomy
R3838 T13800 T13801 det the,susceptibility
R3839 T13801 T13799 pobj susceptibility,in
R3840 T13802 T13801 cc and,susceptibility
R3841 T13803 T13801 conj control,susceptibility
R3842 T13804 T13801 prep of,susceptibility
R3843 T13805 T13804 pobj obesity,of
R3844 T13806 T13791 punct ", ",designed
R3845 T13807 T13808 det this,study
R3846 T13808 T13791 nsubjpass study,designed
R3847 T13809 T13791 auxpass was,designed
R3848 T13810 T13811 aux to,power
R3849 T13811 T13791 xcomp power,designed
R3850 T13812 T13811 advmod sufficiently,power
R3851 T13813 T13814 det the,detection
R3852 T13814 T13811 dobj detection,power
R3853 T13815 T13814 prep of,detection
R3854 T13816 T13817 amod significant,QTLs
R3855 T13817 T13815 pobj QTLs,of
R3856 T13818 T13817 prep for,QTLs
R3857 T13819 T13818 pobj this,for
R3858 T13820 T13819 cc and,this
R3859 T13821 T13822 amod other,traits
R3860 T13822 T13819 conj traits,this
R3861 T13823 T13822 prep with,traits
R3862 T13824 T13825 npadvmod sex,dependent
R3863 T13825 T13827 amod dependent,effects
R3864 T13826 T13825 punct -,dependent
R3865 T13827 T13823 pobj effects,with
R3866 T13828 T13791 punct .,designed
R3867 T13831 T13830 punct ", ",Note
R3868 T13832 T13830 advmod however,Note
R3869 T13833 T13830 punct ", ",Note
R3870 T13834 T13835 mark that,extend
R3871 T13835 T13830 ccomp extend,Note
R3872 T13836 T13837 det these,effects
R3873 T13837 T13835 nsubj effects,extend
R3874 T13838 T13835 aux can,extend
R3875 T13839 T13835 prep to,extend
R3876 T13840 T13839 pobj traits,to
R3877 T13841 T13840 prep without,traits
R3878 T13842 T13843 amod overall,differences
R3879 T13843 T13841 pobj differences,without
R3880 T13844 T13843 compound mean,differences
R3881 T13845 T13843 prep between,differences
R3882 T13846 T13847 det the,sexes
R3883 T13847 T13845 pobj sexes,between
R3884 T13848 T13830 punct .,Note
R3885 T13850 T13851 amod Previous,studies
R3886 T13851 T13852 nsubj studies,described
R3887 T13853 T13852 aux have,described
R3888 T13854 T13855 det the,advantages
R3889 T13855 T13852 dobj advantages,described
R3890 T13856 T13855 prep of,advantages
R3891 T13857 T13856 pcomp performing,of
R3892 T13858 T13859 compound QTL,analysis
R3893 T13859 T13857 dobj analysis,performing
R3894 T13860 T13861 preconj both,with
R3895 T13861 T13859 prep with,analysis
R3896 T13862 T13861 cc and,with
R3897 T13863 T13861 conj without,with
R3898 T13864 T13863 pobj sex,without
R3899 T13865 T13864 prep as,sex
R3900 T13866 T13867 det an,covariate
R3901 T13867 T13865 pobj covariate,as
R3902 T13868 T13867 amod interactive,covariate
R3903 T13869 T13870 punct [,22
R3904 T13870 T13852 parataxis 22,described
R3905 T13871 T13872 punct –,25
R3906 T13872 T13870 prep 25,22
R3907 T13873 T13870 punct ],22
R3908 T13874 T13852 punct .,described
R3909 T13876 T13877 csubj Analyzing,is
R3910 T13878 T13879 det the,sexes
R3911 T13879 T13876 dobj sexes,Analyzing
R3912 T13880 T13876 advmod separately,Analyzing
R3913 T13881 T13877 acomp suboptimal,is
R3914 T13882 T13883 mark since,reduces
R3915 T13883 T13877 advcl reduces,is
R3916 T13884 T13883 nsubj it,reduces
R3917 T13885 T13886 compound sample,size
R3918 T13886 T13883 dobj size,reduces
R3919 T13887 T13883 prep in,reduces
R3920 T13888 T13889 det both,groups
R3921 T13889 T13887 pobj groups,in
R3922 T13890 T13883 punct ", ",reduces
R3923 T13891 T13892 advmod thus,reducing
R3924 T13892 T13883 advcl reducing,reduces
R3925 T13893 T13892 dobj power,reducing
R3926 T13894 T13895 aux to,detect
R3927 T13895 T13893 acl detect,power
R3928 T13896 T13897 amod main,effects
R3929 T13897 T13895 dobj effects,detect
R3930 T13898 T13897 compound QTL,effects
R3931 T13899 T13892 punct ", ",reducing
R3932 T13900 T13901 mark as,demonstrated
R3933 T13901 T13892 advcl demonstrated,reducing
R3934 T13902 T13901 agent by,demonstrated
R3935 T13903 T13904 poss our,scan
R3936 T13904 T13902 pobj scan,by
R3937 T13905 T13904 compound genome,scan
R3938 T13906 T13904 prep of,scan
R3939 T13907 T13906 pobj Chromosome,of
R3940 T13908 T13907 nummod 5,Chromosome
R3941 T13909 T13910 punct (,1B
R3942 T13910 T13877 parataxis 1B,is
R3943 T13911 T13910 compound Figure,1B
R3944 T13912 T13910 punct ),1B
R3945 T13913 T13877 punct .,is
R3946 T13915 T13916 advmod Furthermore,allow
R3947 T13917 T13916 punct ", ",allow
R3948 T13918 T13919 amod separate,analyses
R3949 T13919 T13916 nsubj analyses,allow
R3950 T13920 T13916 aux would,allow
R3951 T13921 T13916 neg not,allow
R3952 T13922 T13916 prep for,allow
R3953 T13923 T13924 det the,detection
R3954 T13924 T13922 pobj detection,for
R3955 T13925 T13924 prep of,detection
R3956 T13926 T13925 pobj QTLs,of
R3957 T13927 T13928 dep that,have
R3958 T13928 T13926 relcl have,QTLs
R3959 T13929 T13930 amod opposing,effects
R3960 T13930 T13928 dobj effects,have
R3961 T13931 T13929 punct ", ",opposing
R3962 T13932 T13929 cc or,opposing
R3963 T13933 T13934 npadvmod sex,antagonistic
R3964 T13934 T13929 conj antagonistic,opposing
R3965 T13935 T13934 punct -,antagonistic
R3966 T13936 T13930 punct ", ",effects
R3967 T13937 T13928 prep in,have
R3968 T13938 T13937 pobj females,in
R3969 T13939 T13938 cc and,females
R3970 T13940 T13938 conj males,females
R3971 T13941 T13916 cc and,allow
R3972 T13942 T13943 aux would,hinder
R3973 T13943 T13916 conj hinder,allow
R3974 T13944 T13945 det the,detection
R3975 T13945 T13943 dobj detection,hinder
R3976 T13946 T13945 prep of,detection
R3977 T13947 T13946 pobj QTLs,of
R3978 T13948 T13947 amod specific,QTLs
R3979 T13949 T13948 prep to,specific
R3980 T13950 T13951 nummod one,sex
R3981 T13951 T13949 pobj sex,to
R3982 T13952 T13916 punct .,allow
R3983 T13954 T13955 advmod Accordingly,detected
R3984 T13956 T13955 punct ", ",detected
R3985 T13957 T13955 nsubj we,detected
R3986 T13958 T13959 nummod five,cQTLs
R3987 T13959 T13955 dobj cQTLs,detected
R3988 T13960 T13959 prep for,cQTLs
R3989 T13961 T13962 det the,trait
R3990 T13962 T13960 pobj trait,for
R3991 T13963 T13964 amod gonadal,mass
R3992 T13964 T13962 compound mass,trait
R3993 T13965 T13964 compound fat,mass
R3994 T13966 T13955 prep on,detected
R3995 T13967 T13968 nmod Chromosomes,1
R3996 T13968 T13966 pobj 1,on
R3997 T13969 T13968 punct ", ",1
R3998 T13970 T13968 conj 3,1
R3999 T13971 T13970 punct ", ",3
R4000 T13972 T13970 conj 5,3
R4001 T13973 T13972 punct ", ",5
R4002 T13974 T13972 conj 11,5
R4003 T13975 T13974 punct ", ",11
R4004 T13976 T13974 cc and,11
R4005 T13977 T13974 conj 19,11
R4006 T13978 T13955 punct .,detected
R4007 T13980 T13981 det The,detection
R4008 T13981 T13982 nsubjpass detection,driven
R4009 T13983 T13981 prep of,detection
R4010 T13984 T13985 det all,cQTLs
R4011 T13985 T13983 pobj cQTLs,of
R4012 T13986 T13985 nummod five,cQTLs
R4013 T13987 T13982 auxpass was,driven
R4014 T13988 T13982 punct “,driven
R4015 T13989 T13982 punct ”,driven
R4016 T13990 T13982 agent by,driven
R4017 T13991 T13992 det the,effect
R4018 T13992 T13990 pobj effect,by
R4019 T13993 T13992 amod larger,effect
R4020 T13994 T13982 prep in,driven
R4021 T13995 T13994 pobj females,in
R4022 T13996 T13982 punct ", ",driven
R4023 T13997 T13982 prep with,driven
R4024 T13998 T13999 amod significant,improvement
R4025 T13999 T13997 pobj improvement,with
R4026 T14000 T13999 prep by,improvement
R4027 T14001 T14002 det the,incorporation
R4028 T14002 T14000 pobj incorporation,by
R4029 T14003 T14002 prep of,incorporation
R4030 T14004 T14005 npadvmod sex,additive
R4031 T14005 T14007 amod additive,parameters
R4032 T14006 T14005 punct *,additive
R4033 T14007 T14003 pobj parameters,of
R4034 T14008 T14005 cc and,additive
R4035 T14009 T14010 npadvmod sex,dominant
R4036 T14010 T14005 conj dominant,additive
R4037 T14011 T14010 punct *,dominant
R4038 T14012 T13982 punct .,driven
R4039 T14014 T14015 nsubjpass QTLs,overlapping
R4040 T14016 T14014 acl associated,QTLs
R4041 T14017 T14016 prep with,associated
R4042 T14018 T14017 pobj obesity,with
R4043 T14019 T14018 punct ", ",obesity
R4044 T14020 T14021 amod gonadal,fat
R4045 T14021 T14018 conj fat,obesity
R4046 T14022 T14021 punct ", ",fat
R4047 T14023 T14021 cc and,fat
R4048 T14024 T14025 amod abdominal,fat
R4049 T14025 T14021 conj fat,fat
R4050 T14026 T14015 aux have,overlapping
R4051 T14027 T14015 auxpass been,overlapping
R4052 T14028 T14015 aux reported,overlapping
R4053 T14029 T14015 advmod before,overlapping
R4054 T14030 T14015 prep with,overlapping
R4055 T14031 T14030 pobj cQTLs,with
R4056 T14032 T14031 prep on,cQTLs
R4057 T14033 T14034 nmod Chromosomes,1
R4058 T14034 T14032 pobj 1,on
R4059 T14035 T14036 punct [,26
R4060 T14036 T14034 parataxis 26,1
R4061 T14037 T14038 punct –,28
R4062 T14038 T14036 prep 28,26
R4063 T14039 T14036 punct ],26
R4064 T14040 T14034 punct ", ",1
R4065 T14041 T14034 conj 5,1
R4066 T14042 T14043 punct [,29
R4067 T14043 T14041 parataxis 29,5
R4068 T14044 T14043 nummod 26,29
R4069 T14045 T14043 punct ",",29
R4070 T14046 T14043 punct ],29
R4071 T14047 T14041 punct ", ",5
R4072 T14048 T14041 cc and,5
R4073 T14049 T14041 conj 11,5
R4074 T14050 T14051 punct [,29
R4075 T14051 T14049 parataxis 29,11
R4076 T14052 T14051 nummod 19,29
R4077 T14053 T14051 punct ",",29
R4078 T14054 T14051 punct ],29
R4079 T14055 T14034 acl reported,1
R4080 T14056 T14055 advmod here,reported
R4081 T14057 T14015 punct ", ",overlapping
R4082 T14058 T14059 mark whereas,represents
R4083 T14059 T14015 advcl represents,overlapping
R4084 T14060 T14061 det the,cQTL
R4085 T14061 T14059 nsubj cQTL,represents
R4086 T14062 T14061 prep on,cQTL
R4087 T14063 T14062 pobj Chromosome,on
R4088 T14064 T14063 nummod 3,Chromosome
R4089 T14065 T14066 det a,QTL
R4090 T14066 T14059 dobj QTL,represents
R4091 T14067 T14066 amod novel,QTL
R4092 T14068 T14066 prep for,QTL
R4093 T14069 T14070 det this,trait
R4094 T14070 T14068 pobj trait,for
R4095 T14071 T14015 punct .,overlapping
R4096 T14073 T14074 det The,cQTL
R4097 T14074 T14077 nsubjpass cQTL,reported
R4098 T14075 T14074 nmod Chromosome,cQTL
R4099 T14076 T14075 nummod 19,Chromosome
R4100 T14078 T14074 prep for,cQTL
R4101 T14079 T14080 compound fat,mass
R4102 T14080 T14078 pobj mass,for
R4103 T14081 T14077 auxpass was,reported
R4104 T14082 T14077 advmod recently,reported
R4105 T14083 T14077 agent by,reported
R4106 T14084 T14083 pobj us,by
R4107 T14085 T14086 punct [,5
R4108 T14086 T14077 parataxis 5,reported
R4109 T14087 T14086 punct ],5
R4110 T14088 T14077 prep in,reported
R4111 T14089 T14090 det the,progeny
R4112 T14090 T14088 pobj progeny,in
R4113 T14091 T14092 compound BXD,intercross
R4114 T14092 T14090 compound intercross,progeny
R4115 T14093 T14090 compound F2,progeny
R4116 T14094 T14090 prep from,progeny
R4117 T14095 T14096 det the,strains
R4118 T14096 T14094 pobj strains,from
R4119 T14097 T14096 appos B6,strains
R4120 T14098 T14097 cc and,B6
R4121 T14099 T14097 conj DBA,B6
R4122 T14100 T14099 punct (,DBA
R4123 T14101 T14102 dep which,shares
R4124 T14102 T14099 relcl shares,DBA
R4125 T14103 T14104 det the,haplotype
R4126 T14104 T14102 dobj haplotype,shares
R4127 T14105 T14104 amod same,haplotype
R4128 T14106 T14102 prep at,shares
R4129 T14107 T14108 det this,region
R4130 T14108 T14106 pobj region,at
R4131 T14109 T14102 prep as,shares
R4132 T14110 T14111 det the,strain
R4133 T14111 T14109 pobj strain,as
R4134 T14112 T14111 compound C3H,strain
R4135 T14113 T14111 acl used,strain
R4136 T14114 T14113 prep in,used
R4137 T14115 T14116 det this,study
R4138 T14116 T14114 pobj study,in
R4139 T14117 T14077 punct ),reported
R4140 T14118 T14077 punct .,reported
R4141 T14120 T14121 advmod Interestingly,seen
R4142 T14122 T14121 punct ", ",seen
R4143 T14123 T14124 amod significant,heritability
R4144 T14124 T14121 nsubjpass heritability,seen
R4145 T14125 T14124 cc and,heritability
R4146 T14126 T14127 amod genetic,regulation
R4147 T14127 T14124 conj regulation,heritability
R4148 T14128 T14121 auxpass was,seen
R4149 T14129 T14121 prep in,seen
R4150 T14130 T14131 det this,population
R4151 T14131 T14129 pobj population,in
R4152 T14132 T14131 compound F2,population
R4153 T14133 T14121 prep despite,seen
R4154 T14134 T14135 det the,background
R4155 T14135 T14133 pobj background,despite
R4156 T14136 T14135 amod hyperlipidemic,background
R4157 T14137 T14135 punct ", ",background
R4158 T14138 T14135 amod proinflammatory,background
R4159 T14139 T14135 nmod ApoE,background
R4160 T14140 T14139 punct −,ApoE
R4161 T14141 T14139 punct /,ApoE
R4162 T14142 T14139 punct −,ApoE
R4163 T14143 T14135 cc and,background
R4164 T14144 T14145 det the,diet
R4165 T14145 T14135 conj diet,background
R4166 T14146 T14147 amod high,fat
R4167 T14147 T14145 compound fat,diet
R4168 T14148 T14147 punct -,fat
R4169 T14149 T14145 compound Western,diet
R4170 T14150 T14121 punct .,seen
R4171 T14152 T14153 det This,background
R4172 T14153 T14154 nsubj background,possesses
R4173 T14155 T14156 amod several,advantages
R4174 T14156 T14154 dobj advantages,possesses
R4175 T14157 T14156 punct ", ",advantages
R4176 T14158 T14159 amod such,as
R4177 T14159 T14156 prep as,advantages
R4178 T14160 T14159 pcomp allowing,as
R4179 T14161 T14162 det the,modeling
R4180 T14162 T14160 dobj modeling,allowing
R4181 T14163 T14162 prep of,modeling
R4182 T14164 T14165 amod human,like
R4183 T14165 T14167 amod like,states
R4184 T14166 T14165 punct -,like
R4185 T14167 T14163 pobj states,of
R4186 T14168 T14167 compound disease,states
R4187 T14169 T14154 punct .,possesses
R4188 T14171 T14172 det The,effects
R4189 T14172 T14177 nsubj effects,reflect
R4190 T14173 T14174 advmod predominantly,driven
R4191 T14174 T14172 amod driven,effects
R4192 T14175 T14174 amod female,driven
R4193 T14176 T14174 punct -,driven
R4194 T14178 T14172 prep of,effects
R4195 T14179 T14180 det the,cQTLs
R4196 T14180 T14178 pobj cQTLs,of
R4197 T14181 T14180 nummod five,cQTLs
R4198 T14182 T14177 advmod likely,reflect
R4199 T14183 T14184 det the,effect
R4200 T14184 T14177 dobj effect,reflect
R4201 T14185 T14184 amod significant,effect
R4202 T14186 T14184 prep of,effect
R4203 T14187 T14188 amod differential,secretions
R4204 T14188 T14186 pobj secretions,of
R4205 T14189 T14188 amod gonadal,secretions
R4206 T14190 T14188 compound hormone,secretions
R4207 T14191 T14184 prep on,effect
R4208 T14192 T14193 det the,regulation
R4209 T14193 T14191 pobj regulation,on
R4210 T14194 T14193 amod genetic,regulation
R4211 T14195 T14193 prep of,regulation
R4212 T14196 T14197 det this,trait
R4213 T14197 T14195 pobj trait,of
R4214 T14198 T14197 amod complex,trait
R4215 T14199 T14177 punct .,reflect
R4216 T14201 T14202 det The,identification
R4217 T14202 T14203 nsubj identification,remains
R4218 T14204 T14202 prep of,identification
R4219 T14205 T14204 pobj genes,of
R4220 T14206 T14205 acl underlying,genes
R4221 T14207 T14206 dobj cQTLs,underlying
R4222 T14208 T14209 det a,challenge
R4223 T14209 T14203 attr challenge,remains
R4224 T14210 T14203 punct .,remains
R4225 T14212 T14213 det The,availability
R4226 T14213 T14215 nsubj availability,begun
R4227 T14214 T14213 amod widespread,availability
R4228 T14216 T14213 prep of,availability
R4229 T14217 T14218 npadvmod genome,wide
R4230 T14218 T14220 amod wide,analysis
R4231 T14219 T14218 punct -,wide
R4232 T14220 T14216 pobj analysis,of
R4233 T14221 T14220 compound expression,analysis
R4234 T14222 T14215 aux has,begun
R4235 T14223 T14224 aux to,address
R4236 T14224 T14215 xcomp address,begun
R4237 T14225 T14224 dobj this,address
R4238 T14226 T14224 prep by,address
R4239 T14227 T14226 pcomp providing,by
R4240 T14228 T14229 det a,snapshot
R4241 T14229 T14227 dobj snapshot,providing
R4242 T14230 T14229 prep of,snapshot
R4243 T14231 T14230 pobj transcription,of
R4244 T14232 T14231 prep in,transcription
R4245 T14233 T14234 amod relevant,organs
R4246 T14234 T14232 pobj organs,in
R4247 T14235 T14227 cc and,providing
R4248 T14236 T14237 advmod thus,providing
R4249 T14237 T14227 conj providing,providing
R4250 T14238 T14239 amod initial,information
R4251 T14239 T14237 dobj information,providing
R4252 T14240 T14239 prep for,information
R4253 T14241 T14242 det which,genes
R4254 T14242 T14243 dep genes,differentiate
R4255 T14243 T14240 pcomp differentiate,for
R4256 T14244 T14243 aux can,differentiate
R4257 T14245 T14246 det a,trait
R4258 T14246 T14243 dobj trait,differentiate
R4259 T14247 T14246 amod given,trait
R4260 T14248 T14215 punct .,begun
R4261 T14250 T14251 advmod Furthermore,map
R4262 T14252 T14251 punct ", ",map
R4263 T14253 T14251 prep by,map
R4264 T14254 T14253 pcomp treating,by
R4265 T14255 T14256 compound transcript,levels
R4266 T14256 T14254 dobj levels,treating
R4267 T14257 T14254 prep as,treating
R4268 T14258 T14259 amod quantitative,traits
R4269 T14259 T14257 pobj traits,as
R4270 T14260 T14251 punct ", ",map
R4271 T14261 T14251 nsubj we,map
R4272 T14262 T14251 aux can,map
R4273 T14263 T14264 det the,regulation
R4274 T14264 T14251 dobj regulation,map
R4275 T14265 T14264 amod genetic,regulation
R4276 T14266 T14264 acl underlying,regulation
R4277 T14267 T14268 amod differential,expression
R4278 T14268 T14266 dobj expression,underlying
R4279 T14269 T14268 compound gene,expression
R4280 T14270 T14271 punct (,eQTLs
R4281 T14271 T14251 parataxis eQTLs,map
R4282 T14272 T14271 punct ),eQTLs
R4283 T14273 T14251 punct .,map
R4284 T14275 T14276 det Those,eQTLs
R4285 T14276 T14277 nsubj eQTLs,are
R4286 T14278 T14279 dep that,have
R4287 T14279 T14276 relcl have,eQTLs
R4288 T14280 T14281 npadvmod cis,acting
R4289 T14281 T14283 amod acting,variations
R4290 T14282 T14281 punct -,acting
R4291 T14283 T14279 dobj variations,have
R4292 T14284 T14283 acl affecting,variations
R4293 T14285 T14286 poss their,transcription
R4294 T14286 T14284 dobj transcription,affecting
R4295 T14287 T14288 amod potential,genes
R4296 T14288 T14277 attr genes,are
R4297 T14289 T14288 compound candidate,genes
R4298 T14290 T14288 prep for,genes
R4299 T14291 T14292 det the,trait
R4300 T14292 T14290 pobj trait,for
R4301 T14293 T14277 punct .,are
R4302 T14295 T14296 prep At,detected
R4303 T14297 T14298 det a,level
R4304 T14298 T14295 pobj level,At
R4305 T14299 T14300 amod single,trait
R4306 T14300 T14298 nmod trait,level
R4307 T14301 T14298 punct ", ",level
R4308 T14302 T14303 npadvmod genome,wide
R4309 T14303 T14298 amod wide,level
R4310 T14304 T14303 punct -,wide
R4311 T14305 T14298 compound significance,level
R4312 T14306 T14298 prep of,level
R4313 T14307 T14306 pobj 0.05,of
R4314 T14308 T14296 punct ", ",detected
R4315 T14309 T14296 nsubj we,detected
R4316 T14310 T14311 nummod "6,676",eQTLs
R4317 T14311 T14296 dobj eQTLs,detected
R4318 T14312 T14311 acl representing,eQTLs
R4319 T14313 T14314 nummod "4,998",genes
R4320 T14314 T14312 dobj genes,representing
R4321 T14315 T14314 punct ", ",genes
R4322 T14316 T14317 prep of,were
R4323 T14317 T14314 relcl were,genes
R4324 T14318 T14316 pobj which,of
R4325 T14319 T14317 nsubj "2,118",were
R4326 T14320 T14321 npadvmod cis,acting
R4327 T14321 T14317 acomp acting,were
R4328 T14322 T14321 punct -,acting
R4329 T14323 T14296 punct .,detected
R4330 T14325 T14326 prep At,increased
R4331 T14327 T14328 amod increased,thresholds
R4332 T14328 T14325 pobj thresholds,At
R4333 T14329 T14326 punct ", ",increased
R4334 T14330 T14331 det the,proportion
R4335 T14331 T14326 nsubj proportion,increased
R4336 T14332 T14331 prep of,proportion
R4337 T14333 T14334 compound cis,eQTLs
R4338 T14334 T14332 pobj eQTLs,of
R4339 T14335 T14334 punct -,eQTLs
R4340 T14336 T14326 punct ", ",increased
R4341 T14337 T14338 dep which,is
R4342 T14338 T14326 ccomp is,increased
R4343 T14339 T14338 prep in,is
R4344 T14340 T14341 amod good,agreement
R4345 T14341 T14339 pobj agreement,in
R4346 T14342 T14341 prep with,agreement
R4347 T14343 T14344 amod previous,studies
R4348 T14344 T14342 pobj studies,with
R4349 T14345 T14346 punct [,15
R4350 T14346 T14338 parataxis 15,is
R4351 T14347 T14346 nummod 5,15
R4352 T14348 T14346 punct ",",15
R4353 T14349 T14346 punct ],15
R4354 T14350 T14338 cc and,is
R4355 T14351 T14352 advmod likely,reflects
R4356 T14352 T14338 conj reflects,is
R4357 T14353 T14354 det the,power
R4358 T14354 T14352 dobj power,reflects
R4359 T14355 T14354 amod increased,power
R4360 T14356 T14357 aux to,detect
R4361 T14357 T14354 acl detect,power
R4362 T14358 T14359 npadvmod cis,acting
R4363 T14359 T14361 amod acting,variations
R4364 T14360 T14359 punct -,acting
R4365 T14361 T14357 dobj variations,detect
R4366 T14362 T14361 acl affecting,variations
R4367 T14363 T14362 dobj transcription,affecting
R4368 T14364 T14326 punct .,increased
R4369 T14366 T14367 prep Of,possessed
R4370 T14368 T14369 det all,eQTLs
R4371 T14369 T14366 pobj eQTLs,Of
R4372 T14370 T14369 nummod "6,676",eQTLs
R4373 T14371 T14369 amod significant,eQTLs
R4374 T14372 T14367 punct ", ",possessed
R4375 T14373 T14367 nsubj "1,166",possessed
R4376 T14374 T14375 amod significant,interactions
R4377 T14375 T14367 dobj interactions,possessed
R4378 T14376 T14375 compound sex,interactions
R4379 T14377 T14367 punct .,possessed
R4380 T14379 T14380 prep Of,were
R4381 T14381 T14379 pobj these,Of
R4382 T14382 T14380 punct ", ",were
R4383 T14383 T14380 nsubj 304,were
R4384 T14384 T14380 attr cis,were
R4385 T14385 T14380 cc and,were
R4386 T14386 T14387 nsubj 852,were
R4387 T14387 T14380 conj were,were
R4388 T14388 T14387 attr trans,were
R4389 T14389 T14387 punct ", ",were
R4390 T14390 T14387 conj suggesting,were
R4391 T14391 T14392 mark that,occur
R4392 T14392 T14390 ccomp occur,suggesting
R4393 T14393 T14394 advmod only,minority
R4394 T14394 T14392 nsubj minority,occur
R4395 T14395 T14394 det a,minority
R4396 T14396 T14394 prep of,minority
R4397 T14397 T14398 det the,effects
R4398 T14398 T14396 pobj effects,of
R4399 T14399 T14400 npadvmod sex,specific
R4400 T14400 T14398 amod specific,effects
R4401 T14401 T14400 punct -,specific
R4402 T14402 T14398 prep on,effects
R4403 T14403 T14404 det the,regulation
R4404 T14404 T14402 pobj regulation,on
R4405 T14405 T14404 prep of,regulation
R4406 T14406 T14407 compound gene,expression
R4407 T14407 T14405 pobj expression,of
R4408 T14408 T14392 prep through,occur
R4409 T14409 T14408 pobj polymorphisms,through
R4410 T14410 T14409 prep within,polymorphisms
R4411 T14411 T14412 det the,gene
R4412 T14412 T14410 pobj gene,within
R4413 T14413 T14412 appos itself,gene
R4414 T14414 T14380 punct .,were
R4415 T14416 T14417 advmod Rather,is
R4416 T14418 T14417 punct ", ",is
R4417 T14419 T14420 amod underlying,regulation
R4418 T14420 T14417 nsubj regulation,is
R4419 T14421 T14420 amod genetic,regulation
R4420 T14422 T14420 prep of,regulation
R4421 T14423 T14424 amod most,transcripts
R4422 T14424 T14422 pobj transcripts,of
R4423 T14425 T14426 det the,result
R4424 T14426 T14417 attr result,is
R4425 T14427 T14426 prep of,result
R4426 T14428 T14427 pobj interactions,of
R4427 T14429 T14428 prep between,interactions
R4428 T14430 T14431 compound trans,loci
R4429 T14431 T14429 pobj loci,between
R4430 T14432 T14431 cc and,loci
R4431 T14433 T14434 npadvmod sex,specific
R4432 T14434 T14436 amod specific,factors
R4433 T14435 T14434 punct -,specific
R4434 T14436 T14431 conj factors,loci
R4435 T14437 T14436 punct (,factors
R4436 T14438 T14439 advmod e.g.,hormones
R4437 T14439 T14436 appos hormones,factors
R4438 T14440 T14439 punct ", ",hormones
R4439 T14441 T14417 punct ),is
R4440 T14442 T14417 punct .,is
R4441 T14444 T14445 prep As,is
R4442 T14446 T14444 prep with,As
R4443 T14447 T14446 pobj cQTLs,with
R4444 T14448 T14445 punct ", ",is
R4445 T14449 T14450 compound sex,bias
R4446 T14450 T14445 nsubj bias,is
R4447 T14451 T14450 prep in,bias
R4448 T14452 T14453 det the,regulation
R4449 T14453 T14451 pobj regulation,in
R4450 T14454 T14455 advmod predominantly,trans
R4451 T14455 T14453 amod trans,regulation
R4452 T14456 T14453 amod genetic,regulation
R4453 T14457 T14453 prep of,regulation
R4454 T14458 T14459 compound gene,expression
R4455 T14459 T14457 pobj expression,of
R4456 T14460 T14445 advmod likely,is
R4457 T14461 T14445 acomp secondary,is
R4458 T14462 T14461 prep to,secondary
R4459 T14463 T14464 amod different,profiles
R4460 T14464 T14462 pobj profiles,to
R4461 T14465 T14466 compound sex,hormone
R4462 T14466 T14464 compound hormone,profiles
R4463 T14467 T14445 punct .,is
R4464 T14469 T14470 advmod Recently,demonstrated
R4465 T14471 T14470 punct ", ",demonstrated
R4466 T14472 T14470 advcl using,demonstrated
R4467 T14473 T14474 det a,dataset
R4468 T14474 T14472 dobj dataset,using
R4469 T14475 T14474 amod similar,dataset
R4470 T14476 T14470 punct ", ",demonstrated
R4471 T14477 T14478 poss our,group
R4472 T14478 T14470 nsubj group,demonstrated
R4473 T14479 T14480 mark that,represent
R4474 T14480 T14470 ccomp represent,demonstrated
R4475 T14481 T14482 amod significant,eQTLs
R4476 T14482 T14480 nsubj eQTLs,represent
R4477 T14483 T14482 compound cis,eQTLs
R4478 T14484 T14482 punct -,eQTLs
R4479 T14485 T14486 punct (,5
R4480 T14486 T14482 parataxis 5,eQTLs
R4481 T14487 T14486 nsubj p,5
R4482 T14488 T14486 punct <,5
R4483 T14489 T14486 punct ×,5
R4484 T14490 T14491 nummod 10,5
R4485 T14491 T14486 appos 5,5
R4486 T14492 T14491 punct −,5
R4487 T14493 T14486 punct ),5
R4488 T14494 T14480 advmod largely,represent
R4489 T14495 T14496 amod true,positives
R4490 T14496 T14480 dobj positives,represent
R4491 T14497 T14498 punct [,30
R4492 T14498 T14480 parataxis 30,represent
R4493 T14499 T14498 punct ],30
R4494 T14500 T14480 cc and,represent
R4495 T14501 T14480 conj are,represent
R4496 T14502 T14501 acomp enriched,are
R4497 T14503 T14501 prep for,are
R4498 T14504 T14505 advmod highly,polymorphic
R4499 T14505 T14506 amod polymorphic,regions
R4500 T14506 T14503 pobj regions,for
R4501 T14507 T14506 prep over,regions
R4502 T14508 T14509 det the,genome
R4503 T14509 T14507 pobj genome,over
R4504 T14510 T14509 compound mouse,genome
R4505 T14511 T14470 punct .,demonstrated
R4506 T14513 T14514 det The,eQTLs
R4507 T14514 T14517 nsubj eQTLs,overlap
R4508 T14515 T14514 compound cis,eQTLs
R4509 T14516 T14514 punct -,eQTLs
R4510 T14518 T14514 acl presented,eQTLs
R4511 T14519 T14518 prep in,presented
R4512 T14520 T14519 pobj Table,in
R4513 T14521 T14520 nummod 5,Table
R4514 T14522 T14517 prep with,overlap
R4515 T14523 T14522 pobj one,with
R4516 T14524 T14523 prep of,one
R4517 T14525 T14526 det the,cQTLs
R4518 T14526 T14524 pobj cQTLs,of
R4519 T14527 T14528 amod gonadal,mass
R4520 T14528 T14526 compound mass,cQTLs
R4521 T14529 T14528 compound fat,mass
R4522 T14530 T14517 cc and,overlap
R4523 T14531 T14532 aux should,considered
R4524 T14532 T14517 conj considered,overlap
R4525 T14533 T14532 auxpass be,considered
R4526 T14534 T14535 amod potential,candidates
R4527 T14535 T14532 oprd candidates,considered
R4528 T14536 T14517 punct .,overlap
R4529 T14538 T14539 prep Given,reasoned
R4530 T14540 T14541 det the,effects
R4531 T14541 T14538 pobj effects,Given
R4532 T14542 T14541 compound sex,effects
R4533 T14543 T14541 prep in,effects
R4534 T14544 T14545 det the,cQTLs
R4535 T14545 T14543 pobj cQTLs,in
R4536 T14546 T14547 amod gonadal,mass
R4537 T14547 T14545 compound mass,cQTLs
R4538 T14548 T14547 compound fat,mass
R4539 T14549 T14539 punct ", ",reasoned
R4540 T14550 T14539 nsubj we,reasoned
R4541 T14551 T14552 mark that,receive
R4542 T14552 T14539 ccomp receive,reasoned
R4543 T14553 T14554 det the,eQTLs
R4544 T14554 T14552 nsubj eQTLs,receive
R4545 T14555 T14554 compound cis,eQTLs
R4546 T14556 T14554 punct -,eQTLs
R4547 T14557 T14554 prep with,eQTLs
R4548 T14558 T14559 amod significant,effects
R4549 T14559 T14557 pobj effects,with
R4550 T14560 T14561 npadvmod sex,additive
R4551 T14561 T14559 amod additive,effects
R4552 T14562 T14561 punct *,additive
R4553 T14563 T14561 cc and,additive
R4554 T14564 T14565 npadvmod sex,dominant
R4555 T14565 T14561 conj dominant,additive
R4556 T14566 T14565 punct *,dominant
R4557 T14567 T14552 aux should,receive
R4558 T14568 T14569 compound priority,consideration
R4559 T14569 T14552 dobj consideration,receive
R4560 T14570 T14539 punct .,reasoned
R4561 T14572 T14573 det The,use
R4562 T14573 T14574 nsubj use,is
R4563 T14575 T14573 prep of,use
R4564 T14576 T14575 pobj eQTLs,of
R4565 T14577 T14578 aux to,dissect
R4566 T14578 T14573 acl dissect,use
R4567 T14579 T14578 dobj cQTLs,dissect
R4568 T14580 T14581 det a,method
R4569 T14581 T14574 attr method,is
R4570 T14582 T14583 advmod still,in
R4571 T14583 T14581 prep in,method
R4572 T14584 T14585 poss its,infancy
R4573 T14585 T14583 pobj infancy,in
R4574 T14586 T14581 punct ", ",method
R4575 T14587 T14581 prep with,method
R4576 T14588 T14589 amod uncertain,efficacy
R4577 T14589 T14587 pobj efficacy,with
R4578 T14590 T14589 cc and,efficacy
R4579 T14591 T14589 conj applicability,efficacy
R4580 T14592 T14574 punct .,is
R4581 T14594 T14595 advmod Nevertheless,provides
R4582 T14596 T14595 punct ", ",provides
R4583 T14597 T14595 nsubj application,provides
R4584 T14598 T14597 prep of,application
R4585 T14599 T14600 det this,analysis
R4586 T14600 T14598 pobj analysis,of
R4587 T14601 T14597 prep to,application
R4588 T14602 T14603 det this,dataset
R4589 T14603 T14601 pobj dataset,to
R4590 T14604 T14605 det some,genes
R4591 T14605 T14595 dobj genes,provides
R4592 T14606 T14607 advmod tantalizingly,attractive
R4593 T14607 T14605 amod attractive,genes
R4594 T14608 T14605 compound candidate,genes
R4595 T14609 T14595 punct .,provides
R4596 T14611 T14612 nummod One,shortcoming
R4597 T14612 T14613 nsubj shortcoming,is
R4598 T14614 T14612 prep of,shortcoming
R4599 T14615 T14616 det this,approach
R4600 T14616 T14614 pobj approach,of
R4601 T14617 T14613 punct ", ",is
R4602 T14618 T14613 advmod however,is
R4603 T14619 T14613 punct ", ",is
R4604 T14620 T14621 mark that,limited
R4605 T14621 T14613 ccomp limited,is
R4606 T14622 T14623 compound candidate,genes
R4607 T14623 T14621 nsubjpass genes,limited
R4608 T14624 T14621 auxpass are,limited
R4609 T14625 T14621 prep to,limited
R4610 T14626 T14625 pobj those,to
R4611 T14627 T14628 poss whose,levels
R4612 T14628 T14631 dep levels,vary
R4613 T14629 T14630 compound transcript,expression
R4614 T14630 T14628 compound expression,levels
R4615 T14631 T14626 relcl vary,those
R4616 T14632 T14631 prep in,vary
R4617 T14633 T14632 pobj association,in
R4618 T14634 T14633 prep with,association
R4619 T14635 T14636 det a,polymorphism
R4620 T14636 T14634 pobj polymorphism,with
R4621 T14637 T14636 amod nearby,polymorphism
R4622 T14638 T14639 dep that,differs
R4623 T14745 T14746 mark if,is
R4624 T14746 T14740 advcl is,detecting
R4625 T14747 T14748 det the,tissue
R4626 T14748 T14746 nsubj tissue,is
R4627 T14749 T14748 acl arrayed,tissue
R4628 T14750 T14746 neg not,is
R4629 T14751 T14752 det the,tissue
R4630 T14752 T14746 attr tissue,is
R4631 T14753 T14754 advmod where,exerted
R4632 T14639 T14636 relcl differs,polymorphism
R4633 T14754 T14752 relcl exerted,tissue
R4634 T14755 T14756 det the,control
R4635 T14756 T14754 nsubjpass control,exerted
R4636 T14640 T14639 prep between,differs
R4637 T14757 T14754 auxpass is,exerted
R4638 T14641 T14642 det the,strains
R4639 T14642 T14640 pobj strains,between
R4640 T14643 T14642 amod parental,strains
R4641 T14758 T14728 punct .,is
R4642 T14644 T14626 punct —,those
R4643 T14645 T14646 prep in,genes
R4644 T14760 T14761 nsubj This,is
R4645 T14646 T14626 appos genes,those
R4646 T14647 T14648 amod other,words
R4647 T14648 T14645 pobj words,in
R4648 T14649 T14646 punct ", ",genes
R4649 T14650 T14646 prep with,genes
R4650 T14762 T14763 advmod particularly,relevant
R4651 T14651 T14652 amod significant,eQTLs
R4652 T14652 T14650 pobj eQTLs,with
R4653 T14653 T14651 cc and,significant
R4654 T14654 T14651 conj detectable,significant
R4655 T14763 T14761 acomp relevant,is
R4656 T14655 T14652 compound cis,eQTLs
R4657 T14656 T14652 punct -,eQTLs
R4658 T14657 T14613 punct .,is
R4659 T14764 T14763 prep for,relevant
R4660 T14659 T14660 advmod However,is
R4661 T14765 T14766 det a,trait
R4662 T14660 T14663 ccomp is,affect
R4663 T14661 T14660 punct ", ",is
R4664 T14766 T14764 pobj trait,for
R4665 T14662 T14660 nsubj it,is
R4666 T14664 T14660 neg not,is
R4667 T14767 T14768 amod such,as
R4668 T14665 T14666 advmod strictly,necessary
R4669 T14666 T14660 acomp necessary,is
R4670 T14667 T14668 mark for,have
R4671 T14768 T14766 prep as,trait
R4672 T14668 T14660 advcl have,is
R4673 T14669 T14670 compound candidate,genes
R4674 T14670 T14668 nsubj genes,have
R4675 T14769 T14770 compound adipose,mass
R4676 T14671 T14668 aux to,have
R4677 T14672 T14668 dobj evidence,have
R4678 T14673 T14672 prep of,evidence
R4679 T14770 T14768 pobj mass,as
R4680 T14674 T14675 amod such,linkage
R4681 T14675 T14673 pobj linkage,of
R4682 T14676 T14663 punct : ,affect
R4683 T14771 T14770 compound tissue,mass
R4684 T14677 T14663 nsubj polymorphisms,affect
R4685 T14678 T14677 acl underlying,polymorphisms
R4686 T14679 T14680 det a,cQTL
R4687 T14772 T14770 punct ", ",mass
R4688 T14680 T14678 dobj cQTL,underlying
R4689 T14681 T14680 compound trait,cQTL
R4690 T14773 T14774 dep which,controlled
R4691 T14774 T14770 relcl controlled,mass
R4692 T14682 T14663 aux can,affect
R4693 T14775 T14774 auxpass is,controlled
R4694 T14683 T14684 compound gene,function
R4695 T14684 T14663 dobj function,affect
R4696 T14776 T14774 agent by,controlled
R4697 T14685 T14684 cc or,function
R4698 T14686 T14687 amod posttranslational,modifications
R4699 T14687 T14684 conj modifications,function
R4700 T14688 T14663 punct .,affect
R4701 T14777 T14778 amod multiple,tissues
R4702 T14690 T14691 advmod Nevertheless,known
R4703 T14692 T14691 punct ", ",known
R4704 T14778 T14776 pobj tissues,by
R4705 T14693 T14694 amod several,phenotypes
R4706 T14694 T14691 nsubjpass phenotypes,known
R4707 T14695 T14691 auxpass are,known
R4708 T14779 T14761 punct .,is
R4709 T14696 T14697 aux to,regulated
R4710 T14697 T14691 xcomp regulated,known
R4711 T14781 T14782 nsubj We,propose
R4712 T14698 T14697 auxpass be,regulated
R4713 T14699 T14697 punct ", ",regulated
R4714 T14700 T14701 advmod at,least
R4715 T14701 T14702 advmod least,partly
R4716 T14783 T14784 mark that,provide
R4717 T14702 T14703 advmod partly,at
R4718 T14703 T14697 prep at,regulated
R4719 T14704 T14703 punct ", ",at
R4720 T14705 T14706 det the,level
R4721 T14784 T14782 ccomp provide,propose
R4722 T14706 T14703 pobj level,at
R4723 T14707 T14706 prep of,level
R4724 T14708 T14707 pobj transcription,of
R4725 T14785 T14784 nsubj analysis,provide
R4726 T14709 T14708 cc or,transcription
R4727 T14710 T14711 compound mRNA,stability
R4728 T14711 T14708 conj stability,transcription
R4729 T14786 T14785 prep of,analysis
R4730 T14712 T14697 punct ", ",regulated
R4731 T14713 T14714 dep which,is
R4732 T14787 T14788 amod correlated,genes
R4733 T14714 T14697 ccomp is,regulated
R4734 T14715 T14716 advmod exactly,what
R4735 T14716 T14717 dep what,designed
R4736 T14788 T14786 pobj genes,of
R4737 T14717 T14714 ccomp designed,is
R4738 T14718 T14719 poss our,methods
R4739 T14719 T14717 nsubjpass methods,designed
R4740 T14789 T14784 aux can,provide
R4741 T14720 T14717 auxpass are,designed
R4742 T14721 T14722 aux to,detect
R4743 T14722 T14717 xcomp detect,designed
R4744 T14790 T14784 dobj guidance,provide
R4745 T14723 T14691 punct .,known
R4746 T14791 T14792 mark as,discussed
R4747 T14725 T14726 det A,problem
R4748 T14792 T14784 advcl discussed,provide
R4749 T14726 T14728 nsubj problem,is
R4750 T14727 T14726 amod separate,problem
R4751 T14729 T14730 mark that,preclude
R4752 T14793 T14792 advmod below,discussed
R4753 T14730 T14728 ccomp preclude,is
R4754 T14731 T14732 npadvmod organ,specific
R4755 T14732 T14734 amod specific,differences
R4756 T14794 T14782 punct .,propose
R4757 T14733 T14732 punct -,specific
R4758 T14734 T14730 nsubj differences,preclude
R4759 T14735 T14736 compound gene,expression
R4760 T14736 T14734 compound expression,differences
R4761 T14737 T14730 aux may,preclude
R4762 T14738 T14730 dobj one,preclude
R4763 T14739 T14730 prep from,preclude
R4764 T14740 T14739 pcomp detecting,from
R4765 T14741 T14742 det the,gene
R4766 T14742 T14740 dobj gene,detecting
R4767 T14743 T14742 amod relevant,gene
R4768 T14744 T14742 amod causative,gene
R4770 T15737 T15738 nsubj Genes,Illustrate
R4771 T15739 T15737 acl Correlated,Genes
R4772 T15740 T15739 prep with,Correlated
R4773 T15741 T15742 amod Gonadal,Mass
R4774 T15742 T15740 pobj Mass,with
R4775 T15743 T15742 compound Fat,Mass
R4776 T15744 T15745 npadvmod Tissue,Specific
R4777 T15745 T15747 amod Specific,Regulation
R4778 T15746 T15745 punct -,Specific
R4779 T15747 T15738 dobj Regulation,Illustrate
R4780 T15748 T15747 prep of,Regulation
R4781 T15749 T15750 det the,Trait
R4782 T15750 T15748 pobj Trait,of
R4783 T15752 T15753 prep In,fitted
R4784 T15754 T15755 det an,effort
R4785 T15755 T15752 pobj effort,In
R4786 T15756 T15757 aux to,identify
R4787 T15757 T15755 acl identify,effort
R4788 T15758 T15757 dobj genes,identify
R4789 T15759 T15758 acl associated,genes
R4790 T15760 T15759 prep with,associated
R4791 T15761 T15762 det the,trait
R4792 T15762 T15760 pobj trait,with
R4793 T15763 T15764 compound fat,mass
R4794 T15764 T15762 compound mass,trait
R4795 T15765 T15758 punct ", ",genes
R4796 T15766 T15758 cc but,genes
R4797 T15767 T15768 neg not,necessarily
R4798 T15768 T15769 advmod necessarily,genes
R4799 T15769 T15758 conj genes,genes
R4800 T15770 T15769 compound candidate,genes
R4801 T15771 T15769 acl underlying,genes
R4802 T15772 T15773 det the,cQTLs
R4803 T15773 T15771 dobj cQTLs,underlying
R4804 T15774 T15773 compound trait,cQTLs
R4805 T15775 T15753 punct ", ",fitted
R4806 T15776 T15753 nsubj we,fitted
R4807 T15777 T15778 amod linear,models
R4808 T15778 T15753 dobj models,fitted
R4809 T15779 T15780 aux to,assess
R4810 T15780 T15753 advcl assess,fitted
R4811 T15781 T15782 det the,degree
R4812 T15782 T15780 dobj degree,assess
R4813 T15783 T15782 prep of,degree
R4814 T15784 T15783 pobj association,of
R4815 T15785 T15784 prep between,association
R4816 T15786 T15785 pobj transcripts,between
R4817 T15787 T15786 cc and,transcripts
R4818 T15788 T15789 amod gonadal,mass
R4819 T15789 T15786 conj mass,transcripts
R4820 T15790 T15789 compound fat,mass
R4821 T15791 T15753 punct .,fitted
R4822 T15793 T15794 prep As,modeled
R4823 T15795 T15793 prep with,As
R4824 T15796 T15795 pobj QTLs,with
R4825 T15797 T15794 punct ", ",modeled
R4826 T15798 T15799 npadvmod sex,specific
R4827 T15799 T15801 amod specific,correlations
R4828 T15800 T15799 punct -,specific
R4829 T15801 T15794 nsubjpass correlations,modeled
R4830 T15802 T15794 auxpass were,modeled
R4831 T15803 T15794 punct .,modeled
R4832 T15805 T15806 prep At,found
R4833 T15807 T15808 det an,FDR
R4834 T15808 T15805 pobj FDR,At
R4835 T15809 T15808 prep of,FDR
R4836 T15810 T15811 nummod 1,%
R4837 T15811 T15809 pobj %,of
R4838 T15812 T15806 punct ", ",found
R4839 T15813 T15814 nummod "4,613",genes
R4840 T15814 T15806 nsubjpass genes,found
R4841 T15815 T15806 auxpass were,found
R4842 T15816 T15817 aux to,correlated
R4843 T15817 T15806 xcomp correlated,found
R4844 T15818 T15817 auxpass be,correlated
R4845 T15819 T15817 advmod significantly,correlated
R4846 T15820 T15817 prep with,correlated
R4847 T15821 T15822 amod gonadal,mass
R4848 T15822 T15820 pobj mass,with
R4849 T15823 T15822 compound fat,mass
R4850 T15824 T15806 punct ", ",found
R4851 T15825 T15826 prep of,showed
R4852 T15826 T15806 ccomp showed,found
R4853 T15827 T15825 pobj which,of
R4854 T15828 T15826 nsubj "4,254",showed
R4855 T15829 T15830 punct (,%
R4856 T15830 T15828 parataxis %,"4,254"
R4857 T15831 T15830 nummod 98,%
R4858 T15832 T15830 punct ),%
R4859 T15833 T15834 npadvmod sex,biased
R4860 T15834 T15836 amod biased,correlation
R4861 T15835 T15834 punct -,biased
R4862 T15836 T15826 dobj correlation,showed
R4863 T15837 T15806 punct .,found
R4864 T15839 T15840 mark As,indicated
R4865 T15840 T15841 advcl indicated,correlated
R4866 T15842 T15840 prep in,indicated
R4867 T15843 T15844 nmod Tables,4
R4868 T15844 T15842 pobj 4,in
R4869 T15845 T15844 cc and,4
R4870 T15846 T15844 conj 5,4
R4871 T15847 T15841 punct ", ",correlated
R4872 T15848 T15849 amod several,genes
R4873 T15849 T15841 nsubjpass genes,correlated
R4874 T15850 T15849 prep with,genes
R4875 T15851 T15852 amod detectable,eQTLs
R4876 T15852 T15850 pobj eQTLs,with
R4877 T15853 T15852 compound cis,eQTLs
R4878 T15854 T15852 punct -,eQTLs
R4879 T15855 T15841 auxpass are,correlated
R4880 T15856 T15841 advmod also,correlated
R4881 T15857 T15841 advmod significantly,correlated
R4882 T15858 T15841 prep with,correlated
R4883 T15859 T15860 det the,trait
R4884 T15860 T15858 pobj trait,with
R4885 T15861 T15841 cc and,correlated
R4886 T15862 T15863 auxpass are,prioritized
R4887 T15863 T15841 conj prioritized,correlated
R4888 T15864 T15865 advmod even,further
R4889 T15865 T15863 advmod further,prioritized
R4890 T15866 T15863 prep as,prioritized
R4891 T15867 T15868 compound candidate,genes
R4892 T15868 T15866 pobj genes,as
R4893 T15869 T15841 punct .,correlated
R4894 T15871 T15872 advmod Thus,far
R4895 T15872 T15873 advmod far,are
R4896 T15874 T15873 punct ", ",are
R4897 T15875 T15873 nsubj studies,are
R4898 T15876 T15877 dep that,examined
R4899 T15877 T15875 relcl examined,studies
R4900 T15878 T15877 aux have,examined
R4901 T15879 T15880 det the,genetics
R4902 T15880 T15877 dobj genetics,examined
R4903 T15881 T15880 punct “,genetics
R4904 T15882 T15880 prep of,genetics
R4905 T15883 T15884 compound gene,expression
R4906 T15884 T15882 pobj expression,of
R4907 T15885 T15873 punct ”,are
R4908 T15886 T15873 prep in,are
R4909 T15887 T15888 amod good,agreement
R4910 T15888 T15886 pobj agreement,in
R4911 T15889 T15888 prep regarding,agreement
R4912 T15890 T15891 det the,power
R4913 T15891 T15889 pobj power,regarding
R4914 T15892 T15891 amod increased,power
R4915 T15893 T15894 aux to,detect
R4916 T15894 T15891 acl detect,power
R4917 T15895 T15896 compound cis,eQTLs
R4918 T15896 T15894 dobj eQTLs,detect
R4919 T15897 T15896 punct -,eQTLs
R4920 T15898 T15894 advcl relative,detect
R4921 T15899 T15898 prep to,relative
R4922 T15900 T15899 pobj trans,to
R4923 T15901 T15902 punct [,31
R4924 T15902 T15873 parataxis 31,are
R4925 T15903 T15902 nummod 5,31
R4926 T15904 T15902 punct ",",31
R4927 T15905 T15902 nummod 9,31
R4928 T15906 T15902 punct ",",31
R4929 T15907 T15902 nummod 15,31
R4930 T15908 T15902 punct ",",31
R4931 T15909 T15902 nummod 16,31
R4932 T15910 T15902 punct ",",31
R4933 T15911 T15902 punct ],31
R4934 T15912 T15873 punct .,are
R4935 T15914 T15915 nsubj It,is
R4936 T15916 T15915 acomp unclear,is
R4937 T15917 T15915 prep at,is
R4938 T15918 T15919 det this,time
R4939 T15919 T15917 pobj time,at
R4940 T15920 T15915 punct ", ",is
R4941 T15921 T15915 advmod however,is
R4942 T15922 T15915 punct ", ",is
R4943 T15923 T15924 dep what,is
R4944 T15924 T15915 ccomp is,is
R4945 T15925 T15923 advmod exactly,what
R4946 T15926 T15927 det the,significance
R4947 T15927 T15924 attr significance,is
R4948 T15928 T15927 prep of,significance
R4949 T15929 T15930 compound trans,eQTLs
R4950 T15930 T15928 pobj eQTLs,of
R4951 T15931 T15930 punct -,eQTLs
R4952 T15932 T15927 cc and,significance
R4953 T15933 T15934 det the,nature
R4954 T15934 T15927 conj nature,significance
R4955 T15935 T15934 prep of,nature
R4956 T15936 T15937 det the,polymorphisms
R4957 T15937 T15935 pobj polymorphisms,of
R4958 T15938 T15937 amod underlying,polymorphisms
R4959 T15939 T15937 acl associated,polymorphisms
R4960 T15940 T15939 prep with,associated
R4961 T15941 T15940 pobj them,with
R4962 T15942 T15915 punct .,is
R4963 T15944 T15945 advmod Furthermore,represent
R4964 T15946 T15945 punct ", ",represent
R4965 T15947 T15948 det the,hotspots
R4966 T15948 T15945 nsubj hotspots,represent
R4967 T15949 T15948 compound eQTL,hotspots
R4968 T15950 T15948 acl reported,hotspots
R4969 T15951 T15950 prep in,reported
R4970 T15952 T15953 advmod this,previous
R4971 T15953 T15955 amod previous,studies
R4972 T15954 T15953 cc and,previous
R4973 T15955 T15951 pobj studies,in
R4974 T15956 T15957 punct [,10
R4975 T15957 T15948 parataxis 10,hotspots
R4976 T15958 T15957 nummod 5,10
R4977 T15959 T15957 punct ",",10
R4978 T15960 T15957 nummod 9,10
R4979 T15961 T15957 punct ",",10
R4980 T15962 T15957 punct ],10
R4981 T15963 T15945 advmod largely,represent
R4982 T15964 T15965 compound trans,eQTLs
R4983 T15965 T15945 dobj eQTLs,represent
R4984 T15966 T15965 punct -,eQTLs
R4985 T15967 T15945 punct .,represent
R4986 T15969 T15970 det This,localization
R4987 T15970 T15971 nsubj localization,suggests
R4988 T15972 T15973 det some,significance
R4989 T15973 T15971 dobj significance,suggests
R4990 T15974 T15973 amod functional,significance
R4991 T15975 T15973 prep to,significance
R4992 T15976 T15977 det these,regions
R4993 T15977 T15975 pobj regions,to
R4994 T15978 T15971 punct .,suggests
R4995 T15980 T15981 prep Of,generate
R4996 T15982 T15983 det the,genes
R4997 T15983 T15980 pobj genes,Of
R4998 T15984 T15983 nummod "4,613",genes
R4999 T15985 T15983 acl correlated,genes
R5000 T15986 T15985 prep with,correlated
R5001 T15987 T15988 amod gonadal,mass
R5002 T15988 T15986 pobj mass,with
R5003 T15989 T15988 compound fat,mass
R5004 T15990 T15981 punct ", ",generate
R5005 T15991 T15981 nsubj "1,130",generate
R5006 T15992 T15993 nummod "1,478",eQTLs
R5007 T15993 T15981 dobj eQTLs,generate
R5008 T15994 T15993 amod significant,eQTLs
R5009 T15995 T15993 punct ", ",eQTLs
R5010 T15996 T15997 prep of,are
R5011 T15997 T15993 relcl are,eQTLs
R5012 T15998 T15996 pobj which,of
R5013 T15999 T15997 nsubj "1,023",are
R5014 T16000 T16001 punct (,%
R5015 T16001 T15999 parataxis %,"1,023"
R5016 T16002 T16001 nummod 69,%
R5017 T16003 T16001 punct ),%
R5018 T16004 T16005 npadvmod trans,acting
R5019 T16005 T15997 acomp acting,are
R5020 T16006 T16005 punct -,acting
R5021 T16007 T15981 punct .,generate
R5022 T16009 T16010 det These,eQTLs
R5023 T16010 T16011 nsubjpass eQTLs,enriched
R5024 T16012 T16011 auxpass are,enriched
R5025 T16013 T16011 advmod significantly,enriched
R5026 T16014 T16011 prep at,enriched
R5027 T16015 T16016 nummod one,locus
R5028 T16016 T16014 pobj locus,at
R5029 T16017 T16018 punct (,Chromosome
R5030 T16018 T16016 parataxis Chromosome,locus
R5031 T16019 T16018 nummod 19,Chromosome
R5032 T16020 T16018 punct ),Chromosome
R5033 T16021 T16011 punct .,enriched
R5034 T16023 T16024 advmod Interestingly,was
R5035 T16025 T16024 punct ", ",was
R5036 T16026 T16027 det this,hotspot
R5037 T16027 T16024 nsubj hotspot,was
R5038 T16028 T16024 acomp coincident,was
R5039 T16029 T16028 prep with,coincident
R5040 T16030 T16031 det a,cQTL
R5041 T16031 T16029 pobj cQTL,with
R5042 T16032 T16031 acl associated,cQTL
R5043 T16033 T16032 prep with,associated
R5044 T16034 T16035 compound fat,mass
R5045 T16035 T16033 pobj mass,with
R5046 T16036 T16031 acl reported,cQTL
R5047 T16037 T16036 prep in,reported
R5048 T16038 T16039 det this,study
R5049 T16039 T16037 pobj study,in
R5050 T16040 T16024 punct .,was
R5051 T16042 T16043 mark Since,represent
R5052 T16043 T16046 advcl represent,supports
R5053 T16044 T16045 det these,transcripts
R5054 T16045 T16043 nsubj transcripts,represent
R5055 T16047 T16043 dobj those,represent
R5056 T16048 T16049 advmod significantly,correlated
R5057 T16049 T16047 acl correlated,those
R5058 T16050 T16049 prep with,correlated
R5059 T16051 T16052 amod gonadal,mass
R5060 T16052 T16050 pobj mass,with
R5061 T16053 T16052 compound fat,mass
R5062 T16054 T16046 punct ", ",supports
R5063 T16055 T16056 det the,localization
R5064 T16056 T16046 nsubj localization,supports
R5065 T16057 T16056 prep of,localization
R5066 T16058 T16059 poss their,eQTLs
R5067 T16059 T16057 pobj eQTLs,of
R5068 T16060 T16056 prep to,localization
R5069 T16061 T16062 det these,regions
R5070 T16062 T16060 pobj regions,to
R5071 T16063 T16046 advmod strongly,supports
R5072 T16064 T16065 det the,notion
R5073 T16065 T16046 dobj notion,supports
R5074 T16066 T16067 mark that,represent
R5075 T16067 T16065 acl represent,notion
R5076 T16068 T16069 det the,genes
R5077 T16069 T16067 nsubj genes,represent
R5078 T16070 T16069 prep with,genes
R5079 T16071 T16072 compound trans,eQTLs
R5080 T16072 T16070 pobj eQTLs,with
R5081 T16073 T16072 punct -,eQTLs
R5082 T16074 T16075 amod downstream,targets
R5083 T16075 T16067 dobj targets,represent
R5084 T16076 T16075 prep of,targets
R5085 T16077 T16078 nmod candidate,genes
R5086 T16078 T16076 pobj genes,of
R5087 T16079 T16078 amod regulatory,genes
R5088 T16080 T16078 acl located,genes
R5089 T16081 T16080 prep at,located
R5090 T16082 T16083 det the,position
R5091 T16083 T16081 pobj position,at
R5092 T16084 T16083 prep of,position
R5093 T16085 T16086 amod significant,linkage
R5094 T16086 T16084 pobj linkage,of
R5095 T16087 T16046 punct .,supports
R5096 T16089 T16090 nsubj This,means
R5097 T16091 T16092 mark that,be
R5098 T16092 T16090 ccomp be,means
R5099 T16093 T16094 det the,genes
R5100 T16094 T16092 nsubj genes,be
R5101 T16095 T16092 aux may,be
R5102 T16096 T16092 acomp causal,be
R5103 T16097 T16096 cc but,causal
R5104 T16098 T16096 conj downstream,causal
R5105 T16099 T16098 prep of,downstream
R5106 T16100 T16101 det the,gene
R5107 T16101 T16099 pobj gene,of
R5108 T16102 T16101 amod responsible,gene
R5109 T16103 T16102 prep for,responsible
R5110 T16104 T16105 det the,cQTLs
R5111 T16105 T16103 pobj cQTLs,for
R5112 T16106 T16092 punct ", ",be
R5113 T16107 T16092 cc or,be
R5114 T16108 T16109 nsubj they,reacting
R5115 T16109 T16092 conj reacting,be
R5116 T16110 T16109 aux may,reacting
R5117 T16111 T16109 aux be,reacting
R5118 T16112 T16109 prep to,reacting
R5119 T16113 T16114 det the,mass
R5120 T16114 T16112 pobj mass,to
R5121 T16115 T16114 amod increased,mass
R5122 T16116 T16114 amod gonadal,mass
R5123 T16117 T16114 compound fat,mass
R5124 T16118 T16114 cc and,mass
R5125 T16119 T16120 amod associated,changes
R5126 T16120 T16114 conj changes,mass
R5127 T16121 T16120 amod metabolic,changes
R5128 T16122 T16090 punct .,means
R5129 T16124 T16125 det These,data
R5130 T16125 T16126 nsubj data,suggest
R5131 T16127 T16126 advmod also,suggest
R5132 T16128 T16129 mark that,is
R5133 T16129 T16126 ccomp is,suggest
R5134 T16130 T16129 csubj identifying,is
R5135 T16131 T16132 amod such,loci
R5136 T16132 T16130 dobj loci,identifying
R5137 T16133 T16134 dep that,show
R5138 T16134 T16132 relcl show,loci
R5139 T16135 T16134 dobj overrepresentation,show
R5140 T16136 T16135 prep of,overrepresentation
R5141 T16137 T16138 advmod highly,correlated
R5142 T16138 T16139 amod correlated,genes
R5143 T16139 T16136 pobj genes,of
R5144 T16140 T16141 det a,means
R5145 T16141 T16129 attr means,is
R5146 T16142 T16143 aux to,identify
R5147 T16143 T16141 advcl identify,means
R5148 T16144 T16145 dep which,controlled
R5149 T16145 T16143 ccomp controlled,identify
R5150 T16146 T16144 prep of,which
R5151 T16147 T16148 det the,cQTLs
R5152 T16148 T16146 pobj cQTLs,of
R5153 T16149 T16148 compound trait,cQTLs
R5154 T16150 T16145 auxpass are,controlled
R5155 T16151 T16152 advmod more,likely
R5156 T16152 T16145 advmod likely,controlled
R5157 T16153 T16145 agent by,controlled
R5158 T16154 T16155 det the,tissue
R5159 T16155 T16153 pobj tissue,by
R5160 T16156 T16155 acl arrayed,tissue
R5161 T16157 T16126 punct .,suggest
R5162 T16159 T16160 mark As,expected
R5163 T16160 T16161 advcl expected,was
R5164 T16162 T16161 punct ", ",was
R5165 T16163 T16164 det the,locus
R5166 T16164 T16161 nsubj locus,was
R5167 T16165 T16164 nmod Chromosome,locus
R5168 T16166 T16165 nummod 19,Chromosome
R5169 T16167 T16161 acomp enriched,was
R5170 T16168 T16167 prep for,enriched
R5171 T16169 T16170 compound trans,eQTLs
R5172 T16170 T16168 pobj eQTLs,for
R5173 T16171 T16170 punct -,eQTLs
R5174 T16172 T16161 prep with,was
R5175 T16173 T16174 advmod substantially,greater
R5176 T16174 T16175 amod greater,effects
R5177 T16175 T16172 pobj effects,with
R5178 T16176 T16175 prep in,effects
R5179 T16177 T16176 pobj females,in
R5180 T16178 T16161 punct .,was
R5181 T16180 T16181 amod Functional,analysis
R5182 T16181 T16184 nsubj analysis,prove
R5183 T16182 T16180 cc and,Functional
R5184 T16183 T16180 conj promoter,Functional
R5185 T16185 T16181 prep of,analysis
R5186 T16186 T16185 pobj genes,of
R5187 T16187 T16181 prep with,analysis
R5188 T16188 T16189 det a,eQTL
R5189 T16189 T16187 pobj eQTL,with
R5190 T16190 T16189 amod common,eQTL
R5191 T16191 T16189 compound trans,eQTL
R5192 T16192 T16189 punct -,eQTL
R5193 T16193 T16184 aux may,prove
R5194 T16194 T16184 oprd enlightening,prove
R5195 T16195 T16184 punct .,prove
R5196 T16197 T16198 advmod Furthermore,improved
R5197 T16199 T16198 punct ", ",improved
R5198 T16200 T16201 compound gene,expression
R5199 T16201 T16202 compound expression,construction
R5200 T16202 T16198 nsubjpass construction,improved
R5201 T16203 T16202 compound network,construction
R5202 T16204 T16202 cc and,construction
R5203 T16205 T16202 conj analysis,construction
R5204 T16206 T16198 aux may,improved
R5205 T16207 T16198 auxpass be,improved
R5206 T16208 T16198 agent by,improved
R5207 T16209 T16210 det the,incorporation
R5208 T16210 T16208 pobj incorporation,by
R5209 T16211 T16210 prep of,incorporation
R5210 T16212 T16213 advmod experimentally,demonstrated
R5211 T16213 T16214 amod demonstrated,regulation
R5212 T16214 T16211 pobj regulation,of
R5213 T16215 T16216 nmod cis,trans
R5214 T16216 T16214 compound trans,regulation
R5215 T16217 T16216 nmod versus,trans
R5216 T16218 T16198 punct .,improved
R5217 T16908 T16909 det The,integration
R5218 T16909 T16910 nsubjpass integration,proposed
R5219 T16911 T16909 prep of,integration
R5220 T16912 T16913 amod traditional,genetics
R5221 T16913 T16911 pobj genetics,of
R5222 T16914 T16909 prep with,integration
R5223 T16915 T16916 npadvmod genome,wide
R5224 T16916 T16918 amod wide,analysis
R5225 T16917 T16916 punct -,wide
R5226 T16918 T16914 pobj analysis,with
R5227 T16919 T16918 compound expression,analysis
R5228 T16920 T16910 auxpass was,proposed
R5229 T16921 T16910 advmod first,proposed
R5230 T16922 T16910 agent by,proposed
R5231 T16923 T16922 pobj Jansen,by
R5232 T16924 T16923 cc and,Jansen
R5233 T16925 T16923 conj Nap,Jansen
R5234 T16926 T16927 nummod 4,y
R5235 T16927 T16928 npadvmod y,ago
R5236 T16928 T16910 advmod ago,proposed
R5237 T16929 T16930 punct [,32
R5238 T16930 T16910 parataxis 32,proposed
R5239 T16931 T16930 punct ],32
R5240 T16932 T16910 punct .,proposed
R5241 T16934 T16935 nsubj Advances,improved
R5242 T16936 T16934 prep in,Advances
R5243 T16937 T16938 amod genomic,technology
R5244 T16938 T16936 pobj technology,in
R5245 T16939 T16938 cc and,technology
R5246 T16940 T16941 amod bioinformatic,resources
R5247 T16941 T16938 conj resources,technology
R5248 T16942 T16935 prep since,improved
R5249 T16943 T16942 pcomp then,since
R5250 T16944 T16935 aux have,improved
R5251 T16945 T16935 advmod vastly,improved
R5252 T16946 T16947 det the,applicability
R5253 T16947 T16935 dobj applicability,improved
R5254 T16948 T16947 prep of,applicability
R5255 T16949 T16950 det these,methods
R5256 T16950 T16948 pobj methods,of
R5257 T16951 T16947 prep to,applicability
R5258 T16952 T16953 det the,dissection
R5259 T16953 T16951 pobj dissection,to
R5260 T16954 T16953 prep of,dissection
R5261 T16955 T16956 amod complex,traits
R5262 T16956 T16954 pobj traits,of
R5263 T16957 T16935 punct .,improved
R5264 T16959 T16960 csubj Taking,improve
R5265 T16961 T16959 prep into,Taking
R5266 T16962 T16961 pobj account,into
R5267 T16963 T16964 npadvmod sex,specific
R5268 T16964 T16966 amod specific,effects
R5269 T16965 T16964 punct -,specific
R5270 T16966 T16959 dobj effects,Taking
R5271 T16967 T16960 aux will,improve
R5272 T16968 T16960 advmod similarly,improve
R5273 T16969 T16970 det the,sensitivity
R5274 T16970 T16960 dobj sensitivity,improve
R5275 T16971 T16972 aux to,detect
R5276 T16972 T16970 acl detect,sensitivity
R5277 T16973 T16974 amod underlying,regulation
R5278 T16974 T16972 dobj regulation,detect
R5279 T16975 T16974 amod genetic,regulation
R5280 T16976 T16960 punct ", ",improve
R5281 T16977 T16978 advmod especially,for
R5282 T16978 T16960 prep for,improve
R5283 T16979 T16978 pobj phenotypes,for
R5284 T16980 T16979 acl known,phenotypes
R5285 T16981 T16982 aux to,affected
R5286 T16982 T16980 xcomp affected,known
R5287 T16983 T16982 auxpass be,affected
R5288 T16984 T16982 agent by,affected
R5289 T16985 T16984 pobj sex,by
R5290 T16986 T16960 punct .,improve
R5291 T16988 T16989 advmod Furthermore,applied
R5292 T16990 T16989 punct ", ",applied
R5293 T16991 T16992 compound network,analyses
R5294 T16992 T16989 nsubjpass analyses,applied
R5295 T16993 T16989 aux are,applied
R5296 T16994 T16989 advmod increasingly,applied
R5297 T16995 T16989 auxpass being,applied
R5298 T16996 T16989 prep to,applied
R5299 T16997 T16998 amod complex,phenotypes
R5300 T16998 T16996 pobj phenotypes,to
R5301 T16999 T17000 punct [,33
R5302 T17000 T16989 parataxis 33,applied
R5303 T17001 T17000 nummod 11,33
R5304 T17002 T17000 punct ",",33
R5305 T17003 T17000 punct ],33
R5306 T17004 T16989 punct .,applied
R5307 T17006 T17007 advmod Regardless,represent
R5308 T17008 T17006 prep of,Regardless
R5309 T17009 T17010 det which,variables
R5310 T17010 T17011 dep variables,used
R5311 T17011 T17008 pcomp used,of
R5312 T17012 T17011 auxpass are,used
R5313 T17013 T17011 prep in,used
R5314 T17014 T17015 det the,construction
R5315 T17015 T17013 pobj construction,in
R5316 T17016 T17015 prep of,construction
R5317 T17017 T17018 det these,networks
R5318 T17018 T17016 pobj networks,of
R5319 T17019 T17011 punct ", ",used
R5320 T17020 T17021 mark whether,measure
R5321 T17021 T17011 advcl measure,used
R5322 T17022 T17021 nsubj they,measure
R5323 T17023 T17024 compound gene,expression
R5324 T17024 T17021 dobj expression,measure
R5325 T17025 T17024 cc or,expression
R5326 T17026 T17027 compound protein,interactions
R5327 T17027 T17024 conj interactions,expression
R5328 T17028 T17007 punct ", ",represent
R5329 T17029 T17007 csubj accounting,represent
R5330 T17030 T17029 prep for,accounting
R5331 T17031 T17032 compound sex,specificity
R5332 T17032 T17030 pobj specificity,for
R5333 T17033 T17032 punct ", ",specificity
R5334 T17034 T17035 amod hormonal,status
R5335 T17035 T17032 conj status,specificity
R5336 T17036 T17035 punct ", ",status
R5337 T17037 T17035 cc or,status
R5338 T17038 T17035 conj construction,status
R5339 T17039 T17038 prep of,construction
R5340 T17040 T17041 amod different,networks
R5341 T17041 T17039 pobj networks,of
R5342 T17042 T17041 prep for,networks
R5343 T17043 T17042 pobj females,for
R5344 T17044 T17043 cc and,females
R5345 T17045 T17043 conj males,females
R5346 T17046 T17007 aux would,represent
R5347 T17047 T17007 advmod likely,represent
R5348 T17048 T17049 advmod more,accurately
R5349 T17049 T17007 advmod accurately,represent
R5350 T17050 T17051 det the,complexity
R5351 T17051 T17007 dobj complexity,represent
R5352 T17052 T17051 acl associated,complexity
R5353 T17053 T17052 prep with,associated
R5354 T17054 T17055 det these,phenotypes
R5355 T17055 T17053 pobj phenotypes,with
R5356 T17056 T17007 punct .,represent
R5357 T17058 T17059 nsubj We,reported
R5358 T17060 T17059 advmod here,reported
R5359 T17061 T17059 prep on,reported
R5360 T17062 T17063 det the,analysis
R5361 T17063 T17061 pobj analysis,on
R5362 T17064 T17063 amod initial,analysis
R5363 T17065 T17063 amod genetic,analysis
R5364 T17066 T17065 cc and,genetic
R5365 T17067 T17065 conj genomic,genetic
R5366 T17068 T17063 prep of,analysis
R5367 T17069 T17070 det an,population
R5368 T17070 T17068 pobj population,of
R5369 T17071 T17072 compound F2,intercross
R5370 T17072 T17070 compound intercross,population
R5371 T17073 T17070 acl designed,population
R5372 T17074 T17075 aux to,recapitulate
R5373 T17075 T17073 xcomp recapitulate,designed
R5374 T17076 T17077 amod several,traits
R5375 T17077 T17075 dobj traits,recapitulate
R5376 T17078 T17077 acl associated,traits
R5377 T17079 T17078 prep with,associated
R5378 T17080 T17081 amod human,syndrome
R5379 T17081 T17079 pobj syndrome,with
R5380 T17082 T17081 amod metabolic,syndrome
R5381 T17083 T17059 punct .,reported
R5382 T17085 T17086 advcl Using,is
R5383 T17087 T17088 nummod 334,mice
R5384 T17088 T17085 dobj mice,Using
R5385 T17089 T17088 prep of,mice
R5386 T17090 T17091 det both,sexes
R5387 T17091 T17089 pobj sexes,of
R5388 T17092 T17088 acl genotyped,mice
R5389 T17093 T17092 prep at,genotyped
R5390 T17094 T17095 amod high,density
R5391 T17095 T17093 pobj density,at
R5392 T17096 T17086 punct ", ",is
R5393 T17097 T17086 nsubj this,is
R5394 T17098 T17099 det the,study
R5395 T17099 T17086 attr study,is
R5396 T17100 T17099 amod largest,study
R5397 T17101 T17099 prep of,study
R5398 T17102 T17103 poss its,kind
R5399 T17103 T17101 pobj kind,of
R5400 T17104 T17099 prep to,study
R5401 T17105 T17104 pobj date,to
R5402 T17106 T17099 acl designed,study
R5403 T17107 T17086 punct ", ",is
R5404 T17108 T17086 cc and,is
R5405 T17109 T17110 nsubjpass it,powered
R5406 T17110 T17086 conj powered,is
R5407 T17111 T17110 auxpass is,powered
R5408 T17112 T17110 advmod strongly,powered
R5409 T17113 T17114 aux to,detect
R5410 T17114 T17110 xcomp detect,powered
R5411 T17115 T17116 amod subtle,effects
R5412 T17116 T17114 dobj effects,detect
R5413 T17117 T17116 prep of,effects
R5414 T17118 T17119 amod genetic,regulation
R5415 T17119 T17117 pobj regulation,of
R5416 T17120 T17119 cc and,regulation
R5417 T17121 T17122 compound sex,specificity
R5418 T17122 T17119 conj specificity,regulation
R5419 T17123 T17110 punct .,powered
R5420 T17125 T17126 nsubj We,identified
R5421 T17127 T17128 nummod five,cQTLs
R5422 T17128 T17126 dobj cQTLs,identified
R5423 T17129 T17128 prep for,cQTLs
R5424 T17130 T17131 det the,trait
R5425 T17131 T17129 pobj trait,for
R5426 T17132 T17133 amod gonadal,mass
R5427 T17133 T17131 compound mass,trait
R5428 T17134 T17133 compound fat,mass
R5429 T17135 T17128 punct ", ",cQTLs
R5430 T17136 T17128 appos all,cQTLs
R5431 T17137 T17136 prep with,all
R5432 T17138 T17139 amod greater,effects
R5433 T17139 T17137 pobj effects,with
R5434 T17140 T17139 prep in,effects
R5435 T17141 T17140 pobj females,in
R5436 T17142 T17126 punct .,identified
R5437 T17144 T17145 nsubj We,detected
R5438 T17146 T17145 advmod also,detected
R5439 T17147 T17148 amod several,thousand
R5440 T17148 T17149 nummod thousand,eQTLs
R5441 T17149 T17145 dobj eQTLs,detected
R5442 T17150 T17149 amod significant,eQTLs
R5443 T17151 T17149 compound liver,eQTLs
R5444 T17152 T17149 punct ", ",eQTLs
R5445 T17153 T17154 det a,fraction
R5446 T17154 T17156 dep fraction,are
R5447 T17155 T17154 amod significant,fraction
R5448 T17156 T17149 relcl are,eQTLs
R5449 T17157 T17154 prep of,fraction
R5450 T17158 T17157 pobj which,of
R5451 T17159 T17160 npadvmod sex,biased
R5452 T17160 T17156 acomp biased,are
R5453 T17161 T17160 punct -,biased
R5454 T17162 T17156 punct ", ",are
R5455 T17163 T17156 advcl demonstrating,are
R5456 T17164 T17165 advmod how,extend
R5457 T17165 T17163 ccomp extend,demonstrating
R5458 T17166 T17167 amod meaningful,effects
R5459 T17167 T17165 nsubj effects,extend
R5460 T17168 T17167 prep of,effects
R5461 T17169 T17168 pobj sex,of
R5462 T17170 T17167 prep on,effects
R5463 T17171 T17172 compound gene,expression
R5464 T17172 T17170 pobj expression,on
R5465 T17173 T17165 prep beyond,extend
R5466 T17174 T17175 amod overall,differences
R5467 T17175 T17173 pobj differences,beyond
R5468 T17176 T17175 compound mean,differences
R5469 T17177 T17145 punct .,detected
R5470 T17179 T17180 nsubj We,demonstrated
R5471 T17181 T17182 det the,application
R5472 T17182 T17180 dobj application,demonstrated
R5473 T17183 T17182 prep of,application
R5474 T17184 T17185 nmod linkage,methods
R5475 T17185 T17183 pobj methods,of
R5476 T17186 T17184 cc and,linkage
R5477 T17187 T17184 conj correlation,linkage
R5478 T17188 T17189 aux to,identify
R5479 T17189 T17182 acl identify,application
R5480 T17190 T17191 compound candidate,genes
R5481 T17191 T17189 dobj genes,identify
R5482 T17192 T17180 punct .,demonstrated
R5483 T17194 T17195 advmod Finally,showed
R5484 T17196 T17195 punct ", ",showed
R5485 T17197 T17195 nsubj we,showed
R5486 T17198 T17199 mark that,identify
R5487 T17199 T17195 ccomp identify,showed
R5488 T17200 T17199 nsubj localization,identify
R5489 T17201 T17200 prep of,localization
R5490 T17202 T17203 det a,subset
R5491 T17203 T17201 pobj subset,of
R5492 T17204 T17203 prep of,subset
R5493 T17205 T17206 compound liver,genes
R5494 T17206 T17204 pobj genes,of
R5495 T17207 T17206 acl linked,genes
R5496 T17208 T17207 prep in,linked
R5497 T17209 T17208 pobj trans,in
R5498 T17210 T17207 prep to,linked
R5499 T17211 T17212 det a,region
R5500 T17212 T17210 pobj region,to
R5501 T17213 T17212 compound cQTL,region
R5502 T17214 T17199 aux can,identify
R5503 T17215 T17216 amod relative,contributions
R5504 T17216 T17199 dobj contributions,identify
R5505 T17217 T17216 compound tissue,contributions
R5506 T17218 T17216 prep to,contributions
R5507 T17219 T17220 det the,regulation
R5508 T17220 T17218 pobj regulation,to
R5509 T17221 T17220 amod genetic,regulation
R5510 T17222 T17220 prep of,regulation
R5511 T17223 T17224 det a,trait
R5512 T17224 T17222 pobj trait,of
R5513 T17225 T17224 amod complex,trait
R5514 T17226 T17195 punct .,showed
R5515 T17228 T17229 nsubj We,anticipate
R5516 T17230 T17231 mark that,improve
R5517 T17231 T17229 ccomp improve,anticipate
R5518 T17232 T17233 det the,application
R5519 T17233 T17231 nsubj application,improve
R5520 T17234 T17233 prep of,application
R5521 T17235 T17236 advmod these,similar
R5522 T17236 T17238 amod similar,methods
R5523 T17237 T17236 cc and,similar
R5524 T17238 T17234 pobj methods,of
R5525 T17239 T17231 aux would,improve
R5526 T17240 T17231 advmod significantly,improve
R5527 T17241 T17242 det the,elucidation
R5528 T17242 T17231 dobj elucidation,improve
R5529 T17243 T17242 prep of,elucidation
R5530 T17244 T17245 det the,regulation
R5531 T17245 T17243 pobj regulation,of
R5532 T17246 T17245 amod genetic,regulation
R5533 T17247 T17245 acl underlying,regulation
R5534 T17248 T17249 amod complex,phenotypes
R5535 T17249 T17247 dobj phenotypes,underlying
R5536 T17250 T17229 punct .,anticipate
R5537 T17617 T17616 cc and,Animals
R5538 T17618 T17619 compound tissue,collection
R5539 T17619 T17616 conj collection,Animals
R5540 T17620 T17619 punct .,collection
R5541 T17622 T17623 compound C57BL,6J
R5542 T17623 T17625 compound 6J,ApoE
R5543 T17624 T17623 punct /,6J
R5544 T17625 T17626 nsubjpass ApoE,purchased
R5545 T17627 T17625 punct −,ApoE
R5546 T17628 T17625 punct /,ApoE
R5547 T17629 T17625 punct −,ApoE
R5548 T17630 T17625 punct (,ApoE
R5549 T17631 T17625 appos B6.ApoE,ApoE
R5550 T17632 T17631 punct −,B6.ApoE
R5551 T17633 T17631 punct /,B6.ApoE
R5552 T17634 T17631 punct −,B6.ApoE
R5553 T17635 T17626 punct ),purchased
R5554 T17636 T17626 auxpass were,purchased
R5555 T17637 T17626 prep from,purchased
R5556 T17638 T17639 compound Jackson,Laboratory
R5557 T17639 T17637 pobj Laboratory,from
R5558 T17640 T17641 punct (,Harbor
R5559 T17641 T17639 parataxis Harbor,Laboratory
R5560 T17642 T17641 compound Bar,Harbor
R5561 T17643 T17641 punct ", ",Harbor
R5562 T17644 T17641 npadvmod Maine,Harbor
R5563 T17645 T17641 punct ", ",Harbor
R5564 T17646 T17647 compound United,States
R5565 T17647 T17641 npadvmod States,Harbor
R5566 T17648 T17641 punct ),Harbor
R5567 T17649 T17626 punct .,purchased
R5568 T17651 T17652 compound C3H,HeJ
R5569 T17652 T17654 compound HeJ,ApoE
R5570 T17653 T17652 punct /,HeJ
R5571 T17654 T17655 nsubjpass ApoE,generated
R5572 T17656 T17654 punct −,ApoE
R5573 T17657 T17654 punct /,ApoE
R5574 T17658 T17654 punct −,ApoE
R5575 T17659 T17654 punct (,ApoE
R5576 T17660 T17654 appos C3H.ApoE,ApoE
R5577 T17661 T17660 punct −,C3H.ApoE
R5578 T17662 T17660 punct /,C3H.ApoE
R5579 T17663 T17660 punct −,C3H.ApoE
R5580 T17664 T17655 punct ),generated
R5581 T17665 T17655 auxpass were,generated
R5582 T17666 T17655 prep by,generated
R5583 T17667 T17666 pcomp backcrossing,by
R5584 T17668 T17667 dobj B6.ApoE,backcrossing
R5585 T17669 T17668 punct −,B6.ApoE
R5586 T17670 T17668 punct /,B6.ApoE
R5587 T17671 T17668 punct −,B6.ApoE
R5588 T17672 T17667 prep to,backcrossing
R5589 T17673 T17672 pobj C3H,to
R5590 T17674 T17667 prep for,backcrossing
R5591 T17675 T17676 nummod ten,generations
R5592 T17676 T17674 pobj generations,for
R5593 T17677 T17655 punct .,generated
R5594 T17679 T17680 compound F1,mice
R5595 T17680 T17681 nsubjpass mice,generated
R5596 T17682 T17681 auxpass were,generated
R5597 T17683 T17681 prep from,generated
R5598 T17684 T17685 amod reciprocal,intercrossing
R5599 T17685 T17683 pobj intercrossing,from
R5600 T17686 T17685 prep between,intercrossing
R5601 T17687 T17686 pobj B6.ApoE,between
R5602 T17688 T17687 punct −,B6.ApoE
R5603 T17689 T17687 punct /,B6.ApoE
R5604 T17690 T17687 punct −,B6.ApoE
R5605 T17691 T17687 cc and,B6.ApoE
R5606 T17692 T17687 conj C3H.ApoE,B6.ApoE
R5607 T17693 T17692 punct −,C3H.ApoE
R5608 T17694 T17692 punct /,C3H.ApoE
R5609 T17695 T17692 punct −,C3H.ApoE
R5610 T17696 T17681 punct ", ",generated
R5611 T17697 T17681 cc and,generated
R5612 T17698 T17699 compound F2,mice
R5613 T17699 T17700 nsubjpass mice,bred
R5614 T17700 T17681 conj bred,generated
R5615 T17701 T17700 auxpass were,bred
R5616 T17702 T17700 advmod subsequently,bred
R5617 T17703 T17700 prep by,bred
R5618 T17704 T17703 pcomp intercrossing,by
R5619 T17705 T17706 compound F1,mice
R5620 T17706 T17704 dobj mice,intercrossing
R5621 T17707 T17700 punct .,bred
R5622 T17709 T17710 det A,total
R5623 T17710 T17711 nsubjpass total,produced
R5624 T17712 T17710 prep of,total
R5625 T17713 T17714 nummod 334,mice
R5626 T17714 T17712 pobj mice,of
R5627 T17715 T17714 punct (,mice
R5628 T17716 T17714 appos 169,mice
R5629 T17717 T17716 amod female,169
R5630 T17718 T17716 punct ", ",169
R5631 T17719 T17716 appos 165,169
R5632 T17720 T17719 amod male,165
R5633 T17721 T17711 punct ),produced
R5634 T17722 T17711 auxpass were,produced
R5635 T17723 T17711 punct .,produced
R5636 T17725 T17726 det All,mice
R5637 T17726 T17727 nsubjpass mice,fed
R5638 T17728 T17727 auxpass were,fed
R5639 T17729 T17730 compound Purina,Chow
R5640 T17730 T17727 dobj Chow,fed
R5641 T17731 T17730 acl containing,Chow
R5642 T17732 T17733 nummod 4,%
R5643 T17733 T17734 compound %,fat
R5644 T17734 T17731 dobj fat,containing
R5645 T17735 T17727 prep until,fed
R5646 T17736 T17737 nummod 8,wk
R5647 T17737 T17735 pobj wk,until
R5648 T17738 T17737 prep of,wk
R5649 T17739 T17738 pobj age,of
R5650 T17740 T17727 cc and,fed
R5651 T17741 T17742 advmod then,transferred
R5652 T17742 T17727 conj transferred,fed
R5653 T17743 T17742 prep to,transferred
R5654 T17744 T17745 det a,diet
R5655 T17745 T17743 pobj diet,to
R5656 T17746 T17745 punct “,diet
R5657 T17747 T17745 nmod Western,diet
R5658 T17748 T17745 punct ”,diet
R5659 T17749 T17745 acl containing,diet
R5660 T17750 T17751 nummod 42,%
R5661 T17751 T17752 compound %,fat
R5662 T17752 T17749 dobj fat,containing
R5663 T17753 T17752 cc and,fat
R5664 T17754 T17755 nummod 0.15,%
R5665 T17755 T17756 compound %,cholesterol
R5666 T17756 T17752 conj cholesterol,fat
R5667 T17757 T17742 prep for,transferred
R5668 T17758 T17759 nummod 16,wk
R5669 T17759 T17757 pobj wk,for
R5670 T17760 T17727 punct .,fed
R5671 T17762 T17763 nsubjpass Mice,sacrificed
R5672 T17764 T17763 auxpass were,sacrificed
R5673 T17765 T17763 prep at,sacrificed
R5674 T17766 T17767 nummod 24,wk
R5675 T17767 T17765 pobj wk,at
R5676 T17768 T17767 prep of,wk
R5677 T17769 T17768 pobj age,of
R5678 T17770 T17763 punct .,sacrificed
R5679 T17772 T17773 prep At,collected
R5680 T17774 T17772 pobj death,At
R5681 T17775 T17773 punct ", ",collected
R5682 T17776 T17773 nsubjpass livers,collected
R5683 T17777 T17773 auxpass were,collected
R5684 T17778 T17773 advmod immediately,collected
R5685 T17779 T17773 cc and,collected
R5686 T17780 T17781 dep flash,frozen
R5687 T17781 T17773 conj frozen,collected
R5688 T17782 T17781 punct -,frozen
R5689 T17783 T17781 prep in,frozen
R5690 T17784 T17785 compound liquid,N2
R5691 T17785 T17783 pobj N2,in
R5692 T17786 T17773 punct ", ",collected
R5693 T17787 T17773 cc and,collected
R5694 T17788 T17789 amod gonadal,pads
R5695 T17789 T17791 nsubjpass pads,extracted
R5696 T17790 T17789 compound fat,pads
R5697 T17791 T17773 conj extracted,collected
R5698 T17792 T17791 auxpass were,extracted
R5699 T17793 T17791 cc and,extracted
R5700 T17794 T17791 conj weighed,extracted
R5701 T17795 T17773 punct .,collected
R5702 T18362 T18363 compound RNA,sample
R5703 T18363 T18364 compound sample,preparation
R5704 T18365 T18364 punct ", ",preparation
R5705 T18366 T18367 compound microarray,hybridization
R5706 T18367 T18364 conj hybridization,preparation
R5707 T18368 T18367 punct ", ",hybridization
R5708 T18369 T18367 cc and,hybridization
R5709 T18370 T18371 compound expression,analysis
R5710 T18371 T18367 conj analysis,hybridization
R5711 T18372 T18371 punct .,analysis
R5712 T18374 T18375 compound RNA,preparation
R5713 T18375 T18376 nsubjpass preparation,performed
R5714 T18377 T18375 cc and,preparation
R5715 T18378 T18379 compound array,hybridizations
R5716 T18379 T18375 conj hybridizations,preparation
R5717 T18380 T18376 auxpass were,performed
R5718 T18381 T18376 prep at,performed
R5719 T18382 T18383 compound Rosetta,Inpharmatics
R5720 T18383 T18381 pobj Inpharmatics,at
R5721 T18384 T18385 punct (,Seattle
R5722 T18385 T18383 parataxis Seattle,Inpharmatics
R5723 T18386 T18385 punct ", ",Seattle
R5724 T18387 T18385 npadvmod Washington,Seattle
R5725 T18388 T18385 punct ", ",Seattle
R5726 T18389 T18390 compound United,States
R5727 T18390 T18385 npadvmod States,Seattle
R5728 T18391 T18385 punct ),Seattle
R5729 T18392 T18376 punct .,performed
R5730 T18394 T18395 det The,microarrays
R5731 T18395 T18400 nsubj microarrays,contain
R5732 T18396 T18395 compound custom,microarrays
R5733 T18397 T18398 compound ink,jet
R5734 T18398 T18395 compound jet,microarrays
R5735 T18399 T18398 punct -,jet
R5736 T18401 T18395 acl used,microarrays
R5737 T18402 T18401 prep in,used
R5738 T18403 T18404 det this,study
R5739 T18404 T18402 pobj study,in
R5740 T18405 T18406 punct (,described
R5741 T18406 T18395 parataxis described,microarrays
R5742 T18407 T18408 compound Agilent,Technologies
R5743 T18408 T18406 dep Technologies,described
R5744 T18409 T18406 punct ", ",described
R5745 T18410 T18406 advmod previously,described
R5746 T18411 T18412 punct [,34
R5747 T18412 T18406 parataxis 34,described
R5748 T18413 T18412 nummod 21,34
R5749 T18414 T18412 punct ",",34
R5750 T18415 T18412 punct ],34
R5751 T18416 T18406 punct ),described
R5752 T18417 T18418 nummod "2,186",probes
R5753 T18418 T18400 dobj probes,contain
R5754 T18419 T18418 compound control,probes
R5755 T18420 T18418 cc and,probes
R5756 T18421 T18422 nummod "23,574",oligonucleotides
R5757 T18422 T18418 conj oligonucleotides,probes
R5758 T18423 T18422 amod noncontrol,oligonucleotides
R5759 T18424 T18422 acl extracted,oligonucleotides
R5760 T18425 T18424 prep from,extracted
R5761 T18426 T18427 compound mouse,clusters
R5762 T18427 T18425 pobj clusters,from
R5763 T18428 T18427 compound UniGene,clusters
R5764 T18429 T18424 cc and,extracted
R5765 T18430 T18424 conj combined,extracted
R5766 T18431 T18430 prep with,combined
R5767 T18432 T18433 compound RefSeq,sequences
R5768 T18433 T18431 pobj sequences,with
R5769 T18434 T18433 cc and,sequences
R5770 T18435 T18436 nmod RIKEN,clones
R5771 T18436 T18433 conj clones,sequences
R5772 T18437 T18438 amod full,length
R5773 T18438 T18436 compound length,clones
R5774 T18439 T18438 punct -,length
R5775 T18440 T18400 punct .,contain
R5776 T18442 T18443 compound Mouse,livers
R5777 T18443 T18444 nsubjpass livers,homogenized
R5778 T18445 T18444 auxpass were,homogenized
R5779 T18446 T18444 cc and,homogenized
R5780 T18447 T18448 amod total,RNA
R5781 T18448 T18449 nsubj RNA,extracted
R5782 T18449 T18444 conj extracted,homogenized
R5783 T18450 T18449 advcl using,extracted
R5784 T18451 T18452 compound TRIzol,reagent
R5785 T18452 T18450 dobj reagent,using
R5786 T18453 T18454 punct (,Invitrogen
R5787 T18454 T18452 parataxis Invitrogen,reagent
R5788 T18455 T18454 punct ", ",Invitrogen
R5789 T18456 T18454 npadvmod Carlsbad,Invitrogen
R5790 T18457 T18454 punct ", ",Invitrogen
R5791 T18458 T18454 npadvmod California,Invitrogen
R5792 T18459 T18454 punct ", ",Invitrogen
R5793 T18460 T18461 compound United,States
R5794 T18461 T18454 npadvmod States,Invitrogen
R5795 T18462 T18454 punct ),Invitrogen
R5796 T18463 T18449 prep according,extracted
R5797 T18464 T18463 prep to,according
R5798 T18465 T18466 poss manufacturer,protocol
R5799 T18466 T18464 pobj protocol,to
R5800 T18467 T18465 case 's,manufacturer
R5801 T18468 T18449 punct .,extracted
R5802 T18470 T18471 nummod Three,micrograms
R5803 T18471 T18472 nsubjpass micrograms,transcribed
R5804 T18473 T18471 prep of,micrograms
R5805 T18474 T18475 amod total,RNA
R5806 T18475 T18473 pobj RNA,of
R5807 T18476 T18472 auxpass was,transcribed
R5808 T18477 T18472 amod reverse,transcribed
R5809 T18478 T18472 cc and,transcribed
R5810 T18479 T18472 conj labeled,transcribed
R5811 T18480 T18479 prep with,labeled
R5812 T18481 T18482 preconj either,Cy3
R5813 T18482 T18483 nmod Cy3,fluorochrome
R5814 T18483 T18480 pobj fluorochrome,with
R5815 T18484 T18482 cc or,Cy3
R5816 T18485 T18482 conj Cy5,Cy3
R5817 T18486 T18472 punct .,transcribed
R5818 T18488 T18489 amod Purified,RNA
R5819 T18489 T18494 nsubjpass RNA,hybridized
R5820 T18490 T18491 npadvmod Cy3,complementary
R5821 T18491 T18489 amod complementary,RNA
R5822 T18492 T18490 cc or,Cy3
R5823 T18493 T18490 conj Cy5,Cy3
R5824 T18495 T18494 auxpass was,hybridized
R5825 T18496 T18494 prep to,hybridized
R5826 T18497 T18498 advmod at,two
R5827 T18498 T18500 nummod two,slides
R5828 T18499 T18498 advmod least,two
R5829 T18500 T18496 pobj slides,to
R5830 T18501 T18500 compound microarray,slides
R5831 T18502 T18500 prep with,slides
R5832 T18503 T18504 compound fluor,reversal
R5833 T18504 T18502 pobj reversal,with
R5834 T18505 T18494 prep for,hybridized
R5835 T18506 T18507 nummod 24,h
R5836 T18507 T18505 pobj h,for
R5837 T18508 T18494 prep in,hybridized
R5838 T18509 T18510 det a,chamber
R5839 T18510 T18508 pobj chamber,in
R5840 T18511 T18510 compound hybridization,chamber
R5841 T18512 T18494 punct ", ",hybridized
R5842 T18513 T18514 aux washed,scanned
R5843 T18514 T18494 dep scanned,hybridized
R5844 T18515 T18514 punct ", ",scanned
R5845 T18516 T18514 cc and,scanned
R5846 T18517 T18514 advcl using,scanned
R5847 T18518 T18519 det a,scanner
R5848 T18519 T18517 dobj scanner,using
R5849 T18520 T18519 nmod laser,scanner
R5850 T18521 T18519 amod confocal,scanner
R5851 T18522 T18494 punct .,hybridized
R5852 T18524 T18525 nsubjpass Arrays,quantified
R5853 T18526 T18525 auxpass were,quantified
R5854 T18527 T18525 prep on,quantified
R5855 T18528 T18529 det the,basis
R5856 T18529 T18527 pobj basis,on
R5857 T18530 T18529 prep of,basis
R5858 T18531 T18532 compound spot,intensity
R5859 T18532 T18530 pobj intensity,of
R5860 T18533 T18532 amod relative,intensity
R5861 T18534 T18533 prep to,relative
R5862 T18535 T18534 pobj background,to
R5863 T18536 T18525 punct ", ",quantified
R5864 T18537 T18525 conj adjusted,quantified
R5865 T18538 T18537 prep for,adjusted
R5866 T18539 T18540 amod experimental,variation
R5867 T18540 T18538 pobj variation,for
R5868 T18541 T18540 prep between,variation
R5869 T18542 T18541 pobj arrays,between
R5870 T18543 T18542 acl using,arrays
R5871 T18544 T18545 amod average,intensity
R5872 T18545 T18543 dobj intensity,using
R5873 T18546 T18543 prep over,using
R5874 T18547 T18548 amod multiple,channels
R5875 T18548 T18546 pobj channels,over
R5876 T18549 T18537 punct ", ",adjusted
R5877 T18550 T18537 cc and,adjusted
R5878 T18551 T18537 conj fitted,adjusted
R5879 T18552 T18551 prep to,fitted
R5880 T18553 T18554 det an,model
R5881 T18554 T18552 pobj model,to
R5882 T18555 T18554 compound error,model
R5883 T18556 T18557 aux to,determine
R5884 T18557 T18551 advcl determine,fitted
R5885 T18558 T18557 dobj significance,determine
R5886 T18559 T18560 punct (,error
R5887 T18560 T18558 parataxis error,significance
R5888 T18561 T18560 nmod type,error
R5889 T18562 T18561 nummod I,type
R5890 T18563 T18560 punct ),error
R5891 T18564 T18525 punct .,quantified
R5892 T18566 T18567 compound Gene,expression
R5893 T18567 T18568 nsubjpass expression,reported
R5894 T18569 T18568 auxpass is,reported
R5895 T18570 T18568 prep as,reported
R5896 T18571 T18572 det the,mlratio
R5897 T18572 T18570 pobj mlratio,as
R5898 T18573 T18572 amod relative,mlratio
R5899 T18574 T18573 prep to,relative
R5900 T18575 T18576 det the,pool
R5901 T18576 T18574 pobj pool,to
R5902 T18577 T18576 acl derived,pool
R5903 T18578 T18577 prep from,derived
R5904 T18579 T18580 nummod 150,mice
R5905 T18580 T18578 pobj mice,from
R5906 T18581 T18582 advmod randomly,selected
R5907 T18582 T18580 acl selected,mice
R5908 T18583 T18582 prep from,selected
R5909 T18584 T18585 det the,population
R5910 T18585 T18583 pobj population,from
R5911 T18586 T18585 compound F2,population
R5912 T18587 T18568 punct .,reported
R5913 T18589 T18590 prep For,assumed
R5914 T18591 T18592 amod subsequent,analyses
R5915 T18592 T18589 pobj analyses,For
R5916 T18593 T18590 punct ", ",assumed
R5917 T18594 T18595 compound mlratio,data
R5918 T18595 T18590 nsubjpass data,assumed
R5919 T18596 T18590 auxpass are,assumed
R5920 T18597 T18598 aux to,distributed
R5921 T18598 T18590 xcomp distributed,assumed
R5922 T18599 T18598 auxpass be,distributed
R5923 T18600 T18598 advmod normally,distributed
R5924 T18601 T18590 punct ", ",assumed
R5925 T18602 T18603 det a,assumption
R5926 T18603 T18590 npadvmod assumption,assumed
R5927 T18604 T18603 amod valid,assumption
R5928 T18605 T18606 mark as,demonstrated
R5929 T18606 T18603 advcl demonstrated,assumption
R5930 T18607 T18606 advmod previously,demonstrated
R5931 T18608 T18609 punct [,30
R5932 T18609 T18590 parataxis 30,assumed
R5933 T18610 T18609 nummod 21,30
R5934 T18611 T18609 punct ",",30
R5935 T18612 T18609 punct ],30
R5936 T18613 T18590 punct .,assumed
R5937 T18615 T18616 det The,model
R5938 T18616 T18618 nsubjpass model,described
R5939 T18617 T18616 compound error,model
R5940 T18619 T18616 acl used,model
R5941 T18620 T18621 aux to,assess
R5942 T18621 T18619 advcl assess,used
R5943 T18622 T18623 mark whether,expressed
R5944 T18623 T18621 ccomp expressed,assess
R5945 T18624 T18625 det a,gene
R5946 T18625 T18623 nsubjpass gene,expressed
R5947 T18626 T18625 amod given,gene
R5948 T18627 T18623 auxpass is,expressed
R5949 T18628 T18623 advmod significantly,expressed
R5950 T18629 T18623 advmod differentially,expressed
R5951 T18630 T18623 prep in,expressed
R5952 T18631 T18632 det a,sample
R5953 T18632 T18630 pobj sample,in
R5954 T18633 T18632 amod single,sample
R5955 T18634 T18623 advcl relative,expressed
R5956 T18635 T18634 prep to,relative
R5957 T18636 T18637 det a,pool
R5958 T18637 T18635 pobj pool,to
R5959 T18638 T18637 acl comprised,pool
R5960 T18639 T18638 prep of,comprised
R5961 T18640 T18641 det a,subset
R5962 T18641 T18639 pobj subset,of
R5963 T18642 T18643 advmod randomly,selected
R5964 T18643 T18641 amod selected,subset
R5965 T18644 T18641 prep of,subset
R5966 T18645 T18646 nummod 150,samples
R5967 T18646 T18644 pobj samples,of
R5968 T18647 T18618 aux has,described
R5969 T18648 T18618 auxpass been,described
R5970 T18649 T18618 advmod extensively,described
R5971 T18650 T18618 cc and,described
R5972 T18651 T18618 conj tested,described
R5973 T18652 T18651 prep in,tested
R5974 T18653 T18654 det a,number
R5975 T18654 T18652 pobj number,in
R5976 T18655 T18654 prep of,number
R5977 T18656 T18655 pobj publications,of
R5978 T18657 T18658 punct [,36
R5979 T18658 T18651 parataxis 36,tested
R5980 T18659 T18658 nummod 35,36
R5981 T18660 T18658 punct ",",36
R5982 T18661 T18658 punct ],36
R5983 T18662 T18618 punct .,described
R5984 T21143 T21144 nmod Genotyping,statistics
R5985 T21145 T21143 cc and,Genotyping
R5986 T21146 T21143 conj linkage,Genotyping
R5987 T21147 T21144 punct .,statistics
R5988 T21149 T21150 amod Genomic,DNA
R5989 T21150 T21151 nsubjpass DNA,isolated
R5990 T21152 T21151 auxpass was,isolated
R5991 T21153 T21151 prep from,isolated
R5992 T21154 T21153 pobj kidney,from
R5993 T21155 T21151 prep by,isolated
R5994 T21156 T21157 compound phenol,chloroform
R5995 T21157 T21159 compound chloroform,extraction
R5996 T21158 T21157 punct -,chloroform
R5997 T21159 T21155 pobj extraction,by
R5998 T21160 T21151 punct .,isolated
R5999 T21162 T21163 det An,examination
R6000 T21163 T21164 nsubj examination,identified
R6001 T21165 T21163 prep of,examination
R6002 T21166 T21167 amod existing,databases
R6003 T21167 T21165 pobj databases,of
R6004 T21168 T21169 quantmod over,"1,300"
R6005 T21169 T21170 nummod "1,300",SNPs
R6006 T21170 T21164 dobj SNPs,identified
R6007 T21171 T21172 dep that,showed
R6008 T21172 T21170 relcl showed,SNPs
R6009 T21173 T21172 dobj variation,showed
R6010 T21174 T21173 prep between,variation
R6011 T21175 T21176 det the,strains
R6012 T21176 T21174 pobj strains,between
R6013 T21177 T21176 nmod B6,strains
R6014 T21178 T21177 cc and,B6
R6015 T21179 T21177 conj C3H,B6
R6016 T21180 T21164 punct ", ",identified
R6017 T21181 T21164 cc and,identified
R6018 T21182 T21183 det a,map
R6019 T21183 T21186 nsubjpass map,constructed
R6020 T21184 T21183 amod complete,map
R6021 T21185 T21183 compound linkage,map
R6022 T21186 T21164 conj constructed,identified
R6023 T21187 T21183 prep for,map
R6024 T21188 T21189 det all,autosomes
R6025 T21189 T21187 pobj autosomes,for
R6026 T21190 T21189 nummod 19,autosomes
R6027 T21191 T21186 auxpass was,constructed
R6028 T21192 T21186 advcl using,constructed
R6029 T21193 T21192 dobj "1,032",using
R6030 T21194 T21193 prep of,"1,032"
R6031 T21195 T21196 det these,SNPs
R6032 T21196 T21194 pobj SNPs,of
R6033 T21197 T21192 prep at,using
R6034 T21198 T21199 det an,density
R6035 T21199 T21197 pobj density,at
R6036 T21200 T21199 amod average,density
R6037 T21201 T21199 prep of,density
R6038 T21202 T21203 nummod 1.5,cM
R6039 T21203 T21201 pobj cM,of
R6040 T21204 T21186 punct .,constructed
R6041 T21206 T21207 nsubjpass Genotyping,conducted
R6042 T21208 T21207 auxpass was,conducted
R6043 T21209 T21207 agent by,conducted
R6044 T21210 T21209 pobj ParAllele,by
R6045 T21211 T21212 punct (,Francisco
R6046 T21212 T21210 parataxis Francisco,ParAllele
R6047 T21213 T21212 compound South,Francisco
R6048 T21214 T21212 compound San,Francisco
R6049 T21215 T21212 punct ", ",Francisco
R6050 T21216 T21212 npadvmod California,Francisco
R6051 T21217 T21212 punct ", ",Francisco
R6052 T21218 T21219 compound United,States
R6053 T21219 T21212 npadvmod States,Francisco
R6054 T21220 T21212 punct ),Francisco
R6055 T21221 T21207 advcl using,conducted
R6056 T21222 T21223 det the,technique
R6057 T21223 T21221 dobj technique,using
R6058 T21224 T21225 amod molecular,inversion
R6059 T21225 T21227 nmod inversion,probe
R6060 T21226 T21225 punct -,inversion
R6061 T21227 T21223 nmod probe,technique
R6062 T21228 T21227 punct (,probe
R6063 T21229 T21227 appos MIB,probe
R6064 T21230 T21223 punct ),technique
R6065 T21231 T21223 compound multiplex,technique
R6066 T21232 T21233 punct [,37
R6067 T21233 T21207 parataxis 37,conducted
R6068 T21234 T21233 punct ],37
R6069 T21235 T21207 punct .,conducted
R6070 T21237 T21238 nsubjpass Testing,conducted
R6071 T21239 T21237 prep for,Testing
R6072 T21240 T21239 pobj linkage,for
R6073 T21241 T21240 prep of,linkage
R6074 T21242 T21243 preconj both,traits
R6075 T21243 T21241 pobj traits,of
R6076 T21244 T21243 amod clinical,traits
R6077 T21245 T21243 cc and,traits
R6078 T21246 T21247 compound gene,expression
R6079 T21247 T21243 conj expression,traits
R6080 T21248 T21237 punct (,Testing
R6081 T21249 T21237 acl using,Testing
R6082 T21250 T21249 dobj mlratio,using
R6083 T21251 T21238 punct ),conducted
R6084 T21252 T21238 auxpass was,conducted
R6085 T21253 T21238 advcl using,conducted
R6086 T21254 T21255 det a,model
R6087 T21255 T21253 dobj model,using
R6088 T21256 T21255 amod linear,model
R6089 T21257 T21238 punct .,conducted
R6090 T21260 T21261 det a,phenotype
R6091 T21261 T21259 dobj phenotype,Consider
R6092 T21262 T21261 acl denoted,phenotype
R6093 T21263 T21262 prep by,denoted
R6094 T21264 T21263 pobj y,by
R6095 T21265 T21259 punct .,Consider
R6096 T21267 T21268 det The,model
R6097 T21268 T21270 nsubjpass model,given
R6098 T21269 T21268 amod linear,model
R6099 T21271 T21272 dep that,relates
R6100 T21272 T21268 relcl relates,model
R6101 T21273 T21272 dobj variation,relates
R6102 T21274 T21273 prep in,variation
R6103 T21275 T21274 pobj y,in
R6104 T21276 T21272 prep to,relates
R6105 T21277 T21276 pobj QTLs,to
R6106 T21278 T21277 cc and,QTLs
R6107 T21279 T21280 amod other,covariates
R6108 T21280 T21277 conj covariates,QTLs
R6109 T21281 T21280 punct (,covariates
R6110 T21282 T21283 advmod e.g.,sex
R6111 T21283 T21280 appos sex,covariates
R6112 T21284 T21283 punct ", ",sex
R6113 T21285 T21270 punct ),given
R6114 T21286 T21270 auxpass is,given
R6115 T21287 T21270 agent by,given
R6116 T21288 T21289 det the,form
R6117 T21289 T21287 pobj form,by
R6118 T21290 T21289 amod general,form
R6119 T21292 T21293 advmod where,is
R6120 T21294 T21293 nsubj μ,is
R6121 T21295 T21296 det the,mean
R6122 T21296 T21293 attr mean,is
R6123 T21297 T21296 compound trait,mean
R6124 T21298 T21293 punct ", ",is
R6125 T21299 T21300 nsubj X,vector
R6126 T21300 T21293 conj vector,is
R6127 T21301 T21299 punct ′,X
R6128 T21302 T21300 det a,vector
R6129 T21303 T21300 prep of,vector
R6130 T21304 T21303 pobj covariates,of
R6131 T21305 T21300 punct ", ",vector
R6132 T21306 T21307 nsubj β,being
R6133 T21307 T21300 conj being,vector
R6134 T21308 T21309 det the,vector
R6135 T21309 T21307 attr vector,being
R6136 T21310 T21309 amod associated,vector
R6137 T21311 T21309 prep of,vector
R6138 T21312 T21313 compound regression,coefficients
R6139 T21313 T21311 pobj coefficients,of
R6140 T21314 T21307 punct ", ",being
R6141 T21315 T21307 cc and,being
R6142 T21316 T21317 nsubj e,error
R6143 T21317 T21307 conj error,being
R6144 T21318 T21317 det the,error
R6145 T21319 T21317 amod residual,error
R6146 T21320 T21293 punct .,is
R6147 T21322 T21323 nsubjpass Linkage,computed
R6148 T21324 T21323 auxpass was,computed
R6149 T21325 T21323 prep for,computed
R6150 T21326 T21327 quantmod over,20
R6151 T21327 T21328 nummod 20,traits
R6152 T21328 T21325 pobj traits,for
R6153 T21329 T21328 amod clinical,traits
R6154 T21330 T21331 advmod as,as
R6155 T21331 T21328 cc as,traits
R6156 T21332 T21331 advmod well,as
R6157 T21333 T21334 nummod "23,574",transcripts
R6158 T21334 T21328 conj transcripts,traits
R6159 T21335 T21334 compound liver,transcripts
R6160 T21336 T21323 punct .,computed
R6161 T21338 T21339 amod Standard,scans
R6162 T21339 T21341 nsubj scans,calculate
R6163 T21340 T21339 compound genome,scans
R6164 T21342 T21341 dobj linkage,calculate
R6165 T21343 T21341 prep by,calculate
R6166 T21344 T21343 pcomp comparing,by
R6167 T21345 T21346 det the,model
R6168 T21346 T21344 dobj model,comparing
R6169 T21347 T21346 amod linear,model
R6170 T21350 T21351 det the,model
R6171 T21351 T21349 pobj model,to
R6172 T21352 T21351 amod null,model
R6173 T21354 T21355 advmod where,are
R6174 T21356 T21355 nsubj β1,are
R6175 T21357 T21356 cc and,β1
R6176 T21358 T21356 conj β2,β1
R6177 T21359 T21360 det the,coefficients
R6178 T21360 T21355 attr coefficients,are
R6179 T21361 T21360 compound regression,coefficients
R6180 T21362 T21360 prep of,coefficients
R6181 T21363 T21364 det the,parameters
R6182 T21364 T21362 pobj parameters,of
R6183 T21365 T21364 amod additive,parameters
R6184 T21366 T21365 cc and,additive
R6185 T21367 T21365 conj dominant,additive
R6186 T21368 T21355 punct ", ",are
R6187 T21369 T21355 advmod respectively,are
R6188 T21370 T21355 punct .,are
R6189 T21372 T21373 det The,score
R6190 T21373 T21375 nsubj score,represents
R6191 T21374 T21373 compound LOD,score
R6192 T21376 T21377 det the,difference
R6193 T21377 T21375 dobj difference,represents
R6194 T21378 T21377 prep in,difference
R6195 T21379 T21380 det the,log10
R6196 T21380 T21378 pobj log10,in
R6197 T21381 T21380 prep of,log10
R6198 T21382 T21383 det the,likelihood
R6199 T21383 T21381 pobj likelihood,of
R6200 T21384 T21383 prep of,likelihood
R6201 T21385 T21386 det the,equations
R6202 T21386 T21384 pobj equations,of
R6203 T21387 T21386 amod above,equations
R6204 T21388 T21386 nummod two,equations
R6205 T21389 T21377 punct ", ",difference
R6206 T21390 T21391 advmod where,maximized
R6207 T21391 T21377 relcl maximized,difference
R6208 T21392 T21393 det the,likelihoods
R6209 T21393 T21391 nsubjpass likelihoods,maximized
R6210 T21394 T21393 amod individual,likelihoods
R6211 T21395 T21393 compound model,likelihoods
R6212 T21396 T21391 auxpass are,maximized
R6213 T21397 T21391 prep with,maximized
R6214 T21398 T21397 pobj respect,with
R6215 T21399 T21398 prep to,respect
R6216 T21400 T21401 det the,parameters
R6217 T21401 T21399 pobj parameters,to
R6218 T21402 T21401 compound model,parameters
R6219 T21403 T21391 punct ", ",maximized
R6220 T21404 T21391 prep given,maximized
R6221 T21405 T21406 det the,data
R6222 T21406 T21404 pobj data,given
R6223 T21407 T21406 nmod marker,data
R6224 T21408 T21406 nmod genotype,data
R6225 T21409 T21408 cc and,genotype
R6226 T21410 T21408 conj phenotype,genotype
R6227 T21411 T21375 punct .,represents
R6228 T21413 T21414 mark If,differs
R6229 T21414 T21418 advcl differs,model
R6230 T21415 T21416 det a,y
R6231 T21416 T21414 nsubj y,differs
R6232 T21417 T21416 compound trait,y
R6233 T21419 T21414 prep on,differs
R6234 T21420 T21419 amod average,on
R6235 T21421 T21414 prep between,differs
R6236 T21422 T21423 det the,sexes
R6237 T21423 T21421 pobj sexes,between
R6238 T21424 T21423 nummod two,sexes
R6239 T21425 T21414 cc but,differs
R6240 T21426 T21427 det the,QTL
R6241 T21427 T21428 nsubj QTL,has
R6242 T21428 T21414 conj has,differs
R6243 T21429 T21430 det the,effect
R6244 T21430 T21428 dobj effect,has
R6245 T21431 T21430 amod same,effect
R6246 T21432 T21428 prep in,has
R6247 T21433 T21434 preconj both,males
R6248 T21434 T21432 pobj males,in
R6249 T21435 T21434 cc and,males
R6250 T21436 T21434 conj females,males
R6251 T21437 T21418 punct ", ",model
R6252 T21438 T21418 nsubj we,model
R6253 T21439 T21418 aux can,model
R6254 T21440 T21441 det this,interaction
R6255 T21441 T21418 dobj interaction,model
R6256 T21442 T21418 prep by,model
R6257 T21443 T21442 pcomp including,by
R6258 T21444 T21443 dobj sex,including
R6259 T21445 T21443 prep as,including
R6260 T21446 T21447 det an,covariate
R6261 T21447 T21445 pobj covariate,as
R6262 T21448 T21447 amod additive,covariate
R6263 T21449 T21443 prep in,including
R6264 T21450 T21451 det the,models
R6265 T21451 T21449 pobj models,in
R6266 T21452 T21451 amod above,models
R6267 T21453 T21443 punct ", ",including
R6268 T21454 T21443 advcl resulting,including
R6269 T21455 T21454 prep in,resulting
R6270 T21456 T21457 det the,model
R6271 T21457 T21455 pobj model,in
R6272 T21458 T21457 amod new,model
R6273 T21460 T21461 dep which,compared
R6274 T21462 T21461 auxpass is,compared
R6275 T21463 T21461 advmod then,compared
R6276 T21464 T21461 prep to,compared
R6277 T21465 T21466 det the,model
R6278 T21466 T21464 pobj model,to
R6279 T21467 T21466 amod null,model
R6280 T21469 T21470 advmod where,is
R6281 T21471 T21470 nsubj β3,is
R6282 T21472 T21473 det the,coefficient
R6283 T21473 T21470 attr coefficient,is
R6284 T21474 T21473 compound regression,coefficient
R6285 T21475 T21473 prep of,coefficient
R6286 T21476 T21477 det the,parameter
R6287 T21477 T21475 pobj parameter,of
R6288 T21478 T21477 compound sex,parameter
R6289 T21479 T21470 punct .,is
R6290 T21481 T21482 det The,effect
R6291 T21482 T21483 nsubj effect,be
R6292 T21483 T21488 ccomp be,have
R6293 T21484 T21482 prep of,effect
R6294 T21485 T21486 det a,QTL
R6295 T21486 T21484 pobj QTL,of
R6296 T21487 T21483 aux may,be
R6297 T21489 T21483 acomp dependent,be
R6298 T21490 T21489 prep on,dependent
R6299 T21491 T21492 det the,state
R6300 T21492 T21490 pobj state,on
R6301 T21493 T21492 prep of,state
R6302 T21494 T21495 det a,covariate
R6303 T21495 T21493 pobj covariate,of
R6304 T21496 T21488 punct ;,have
R6305 T21497 T21488 prep for,have
R6306 T21498 T21497 pobj instance,for
R6307 T21499 T21488 punct ", ",have
R6308 T21500 T21501 det a,QTL
R6309 T21501 T21488 nsubj QTL,have
R6310 T21502 T21488 aux may,have
R6311 T21503 T21504 det an,effect
R6312 T21504 T21488 dobj effect,have
R6313 T21505 T21504 amod specific,effect
R6314 T21506 T21505 prep to,specific
R6315 T21507 T21508 nummod one,sex
R6316 T21508 T21506 pobj sex,to
R6317 T21509 T21488 punct ", ",have
R6318 T21510 T21488 cc or,have
R6319 T21511 T21512 aux may,have
R6320 T21512 T21488 conj have,have
R6321 T21513 T21514 amod opposite,effects
R6322 T21514 T21512 dobj effects,have
R6323 T21515 T21512 prep in,have
R6324 T21516 T21517 det the,sexes
R6325 T21517 T21515 pobj sexes,in
R6326 T21518 T21517 nummod two,sexes
R6327 T21519 T21488 punct .,have
R6328 T21521 T21522 det This,interaction
R6329 T21522 T21523 nsubjpass interaction,modeled
R6330 T21524 T21523 aux can,modeled
R6331 T21525 T21523 auxpass be,modeled
R6332 T21526 T21523 advcl using,modeled
R6333 T21527 T21528 det a,model
R6334 T21528 T21526 dobj model,using
R6335 T21529 T21528 amod full,model
R6336 T21530 T21528 punct ", ",model
R6337 T21531 T21532 dep which,accounts
R6338 T21532 T21528 relcl accounts,model
R6339 T21533 T21532 prep for,accounts
R6340 T21534 T21535 det all,covariates
R6341 T21535 T21533 pobj covariates,for
R6342 T21536 T21535 amod additive,covariates
R6343 T21537 T21535 punct ", ",covariates
R6344 T21538 T21539 advmod as,as
R6345 T21539 T21535 cc as,covariates
R6346 T21540 T21539 advmod well,as
R6347 T21541 T21535 conj interactions,covariates
R6348 T21542 T21541 prep between,interactions
R6349 T21543 T21544 det the,covariates
R6350 T21544 T21542 pobj covariates,between
R6351 T21545 T21523 punct :,modeled
R6352 T21547 T21548 dep which,compared
R6353 T21549 T21548 auxpass is,compared
R6354 T21550 T21548 prep to,compared
R6355 T21551 T21552 det the,model
R6356 T21552 T21550 pobj model,to
R6357 T21553 T21552 amod above,model
R6358 T21554 T21552 amod null,model
R6359 T21555 T21556 punct (,Equation
R6360 T21556 T21548 parataxis Equation,compared
R6361 T21557 T21556 nummod 5,Equation
R6362 T21558 T21556 punct ),Equation
R6363 T21559 T21548 punct .,compared
R6364 T21561 T21562 det The,model
R6365 T21562 T21564 nsubj model,allows
R6366 T21563 T21562 amod full,model
R6367 T21565 T21566 punct (,Equation
R6368 T21566 T21562 parataxis Equation,model
R6369 T21567 T21566 nummod 6,Equation
R6370 T21568 T21566 punct ),Equation
R6371 T21569 T21570 nsubj us,model
R6372 T21570 T21564 ccomp model,allows
R6373 T21571 T21570 aux to,model
R6374 T21572 T21573 det all,interactions
R6375 T21573 T21570 dobj interactions,model
R6376 T21574 T21573 amod heritable,interactions
R6377 T21575 T21574 cc and,heritable
R6378 T21576 T21577 amod sex,specific
R6379 T21577 T21574 conj specific,heritable
R6380 T21578 T21577 punct -,specific
R6381 T21579 T21570 prep in,model
R6382 T21580 T21581 det a,equation
R6383 T21581 T21579 pobj equation,in
R6384 T21582 T21581 amod single,equation
R6385 T21583 T21570 cc and,model
R6386 T21584 T21585 advmod maximally,powers
R6387 T21585 T21570 conj powers,model
R6388 T21586 T21587 nsubj us,detect
R6389 T21587 T21585 ccomp detect,powers
R6390 T21588 T21587 aux to,detect
R6391 T21589 T21590 amod significant,QTLs
R6392 T21590 T21587 dobj QTLs,detect
R6393 T21591 T21592 advmod when,are
R6394 T21592 T21587 advcl are,detect
R6395 T21593 T21594 det the,terms
R6396 T21594 T21592 nsubj terms,are
R6397 T21595 T21594 nmod sex,terms
R6398 T21596 T21595 cc and,sex
R6399 T21597 T21598 compound sex,interaction
R6400 T21598 T21595 conj interaction,sex
R6401 T21599 T21598 punct -,interaction
R6402 T21600 T21592 acomp significant,are
R6403 T21601 T21587 punct ", ",detect
R6404 T21602 T21587 prep given,detect
R6405 T21603 T21604 det all,animals
R6406 T21604 T21606 nsubjpass animals,included
R6407 T21605 T21604 nummod 334,animals
R6408 T21606 T21602 pcomp included,given
R6409 T21607 T21606 auxpass are,included
R6410 T21608 T21606 prep in,included
R6411 T21609 T21610 det the,analysis
R6412 T21610 T21608 pobj analysis,in
R6413 T21611 T21564 punct .,allows
R6414 T21613 T21614 advmod Furthermore,obviates
R6415 T21615 T21614 punct ", ",obviates
R6416 T21616 T21614 csubj using,obviates
R6417 T21617 T21618 det the,model
R6418 T21618 T21616 dobj model,using
R6419 T21619 T21618 amod full,model
R6420 T21620 T21621 det the,need
R6421 T21621 T21614 dobj need,obviates
R6422 T21622 T21621 prep for,need
R6423 T21623 T21624 compound modeling,QTLs
R6424 T21624 T21622 pobj QTLs,for
R6425 T21625 T21624 prep in,QTLs
R6426 T21626 T21627 nummod one,sex
R6427 T21627 T21625 pobj sex,in
R6428 T21628 T21627 advmod only,sex
R6429 T21629 T21624 punct ", ",QTLs
R6430 T21630 T21631 det a,procedure
R6431 T21631 T21624 appos procedure,QTLs
R6432 T21632 T21633 dep that,decrease
R6433 T21633 T21631 relcl decrease,procedure
R6434 T21634 T21633 aux could,decrease
R6435 T21635 T21636 poss our,power
R6436 T21636 T21633 dobj power,decrease
R6437 T21637 T21633 prep by,decrease
R6438 T21638 T21637 pcomp halving,by
R6439 T21639 T21640 det the,size
R6440 T21640 T21638 dobj size,halving
R6441 T21641 T21640 compound sample,size
R6442 T21642 T21638 punct ", ",halving
R6443 T21643 T21638 advcl rendering,halving
R6444 T21644 T21643 dobj it,rendering
R6445 T21645 T21643 oprd impossible,rendering
R6446 T21646 T21647 aux to,detect
R6447 T21647 T21643 xcomp detect,rendering
R6448 T21648 T21647 dobj interactions,detect
R6449 T21649 T21648 prep between,interactions
R6450 T21650 T21649 pobj QTLs,between
R6451 T21651 T21650 cc and,QTLs
R6452 T21652 T21650 conj sex,QTLs
R6453 T21653 T21614 punct .,obviates
R6454 T21655 T21656 advmod However,is
R6455 T21657 T21656 punct ", ",is
R6456 T21658 T21659 mark because,contains
R6457 T21659 T21656 advcl contains,is
R6458 T21660 T21661 det the,model
R6459 T21661 T21659 nsubj model,contains
R6460 T21662 T21661 amod full,model
R6461 T21663 T21664 nummod two,parameters
R6462 T21664 T21659 dobj parameters,contains
R6463 T21665 T21664 amod more,parameters
R6464 T21666 T21664 prep than,parameters
R6465 T21667 T21668 det the,model
R6466 T21668 T21666 pobj model,than
R6467 T21669 T21670 dep that,treats
R6468 T21670 T21668 relcl treats,model
R6469 T21671 T21670 dobj sex,treats
R6470 T21672 T21670 prep as,treats
R6471 T21673 T21674 det an,covariate
R6472 T21674 T21672 pobj covariate,as
R6473 T21675 T21674 amod additive,covariate
R6474 T21676 T21677 punct (,Equation
R6475 T21677 T21659 parataxis Equation,contains
R6476 T21678 T21677 nummod 4,Equation
R6477 T21679 T21677 punct ),Equation
R6478 T21680 T21656 punct ", ",is
R6479 T21681 T21682 det the,threshold
R6480 T21682 T21656 nsubj threshold,is
R6481 T21683 T21682 compound LOD,threshold
R6482 T21684 T21682 compound score,threshold
R6483 T21685 T21682 prep for,threshold
R6484 T21686 T21687 amod significant,linkage
R6485 T21687 T21685 pobj linkage,for
R6486 T21688 T21656 acomp higher,is
R6487 T21689 T21690 punct (,using
R6488 T21690 T21656 parataxis using,is
R6489 T21691 T21692 det the,convention
R6490 T21692 T21690 dobj convention,using
R6491 T21693 T21692 prep of,convention
R6492 T21694 T21693 pobj Lander,of
R6493 T21695 T21694 cc and,Lander
R6494 T21696 T21694 conj Kruglyak,Lander
R6495 T21697 T21698 punct [,20
R6496 T21698 T21690 parataxis 20,using
R6497 T21699 T21698 punct ],20
R6498 T21700 T21690 punct ),using
R6499 T21701 T21656 punct ", ",is
R6500 T21702 T21656 prep with,is
R6501 T21703 T21704 amod QTL,specific
R6502 T21704 T21706 amod specific,levels
R6503 T21705 T21704 punct -,specific
R6504 T21706 T21702 pobj levels,with
R6505 T21707 T21706 compound significance,levels
R6506 T21708 T21706 prep of,levels
R6507 T21709 T21710 nummod 2,10−3
R6508 T21710 T21708 pobj 10−3,of
R6509 T21711 T21710 punct ×,10−3
R6510 T21712 T21710 cc and,10−3
R6511 T21713 T21714 nummod 5,10−5
R6512 T21714 T21710 conj 10−5,10−3
R6513 T21715 T21714 punct ×,10−5
R6514 T21716 T21710 amod equivalent,10−3
R6515 T21717 T21716 prep to,equivalent
R6516 T21718 T21719 compound LOD,scores
R6517 T21719 T21717 pobj scores,to
R6518 T21720 T21719 prep of,scores
R6519 T21721 T21720 pobj 4.0,of
R6520 T21722 T21723 punct (,linkage
R6521 T21723 T21721 parataxis linkage,4.0
R6522 T21724 T21723 amod suggestive,linkage
R6523 T21725 T21723 punct ),linkage
R6524 T21726 T21721 cc and,4.0
R6525 T21727 T21721 conj 5.4,4.0
R6526 T21728 T21729 punct (,linkage
R6527 T21729 T21727 parataxis linkage,5.4
R6528 T21730 T21729 amod significant,linkage
R6529 T21731 T21729 punct ", ",linkage
R6530 T21732 T21729 amod equivalent,linkage
R6531 T21733 T21732 prep to,equivalent
R6532 T21734 T21735 npadvmod genome,wide
R6533 T21735 T21737 amod wide,p
R6534 T21736 T21735 punct -,wide
R6535 T21737 T21733 pobj p,to
R6536 T21738 T21739 punct <,0.05
R6537 T21739 T21737 amod 0.05,p
R6538 T21740 T21729 punct ),linkage
R6539 T21741 T21721 punct ", ",4.0
R6540 T21742 T21721 advmod respectively,4.0
R6541 T21743 T21656 punct .,is
R6542 T21745 T21746 prep As,reduce
R6543 T21747 T21748 det a,result
R6544 T21748 T21745 pobj result,As
R6545 T21749 T21746 punct ", ",reduce
R6546 T21750 T21751 mark if,are
R6547 T21751 T21746 advcl are,reduce
R6548 T21752 T21751 expl there,are
R6549 T21753 T21754 det no,interactions
R6550 T21754 T21751 attr interactions,are
R6551 T21755 T21754 amod significant,interactions
R6552 T21756 T21757 amod sex,additive
R6553 T21757 T21754 amod additive,interactions
R6554 T21758 T21757 punct -,additive
R6555 T21759 T21757 cc or,additive
R6556 T21760 T21761 amod sex,dominant
R6557 T21761 T21757 conj dominant,additive
R6558 T21762 T21761 punct -,dominant
R6559 T21763 T21746 punct ", ",reduce
R6560 T21764 T21765 det the,model
R6561 T21765 T21746 nsubj model,reduce
R6562 T21766 T21765 amod full,model
R6563 T21767 T21746 aux will,reduce
R6564 T21768 T21746 advmod actually,reduce
R6565 T21769 T21746 dobj power,reduce
R6566 T21770 T21771 aux to,detect
R6567 T21771 T21769 acl detect,power
R6568 T21772 T21771 dobj linkage,detect
R6569 T21773 T21746 punct .,reduce
R6570 T21775 T21776 aux To,minimize
R6571 T21776 T21777 advcl minimize,employed
R6572 T21778 T21779 det the,loss
R6573 T21779 T21776 dobj loss,minimize
R6574 T21780 T21779 prep in,loss
R6575 T21781 T21780 pobj power,in
R6576 T21782 T21779 prep of,loss
R6577 T21783 T21782 pcomp fitting,of
R6578 T21784 T21785 det the,model
R6579 T21785 T21783 dobj model,fitting
R6580 T21786 T21785 amod full,model
R6581 T21787 T21788 advmod when,are
R6582 T21788 T21783 advcl are,fitting
R6583 T21789 T21790 det the,terms
R6584 T21790 T21788 nsubj terms,are
R6585 T21791 T21792 compound sex,interaction
R6586 T21792 T21790 compound interaction,terms
R6587 T21793 T21792 punct -,interaction
R6588 T21794 T21788 neg not,are
R6589 T21795 T21788 acomp significant,are
R6590 T21796 T21777 punct ", ",employed
R6591 T21797 T21777 nsubj we,employed
R6592 T21798 T21799 det a,procedure
R6593 T21799 T21777 dobj procedure,employed
R6594 T21800 T21801 compound model,selection
R6595 T21801 T21799 compound selection,procedure
R6596 T21802 T21803 dep that,introduces
R6597 T21803 T21799 relcl introduces,procedure
R6598 T21804 T21805 compound sex,interaction
R6599 T21805 T21807 compound interaction,terms
R6600 T21806 T21805 punct -,interaction
R6601 T21807 T21803 dobj terms,introduces
R6602 T21808 T21809 advmod only,add
R6603 T21809 T21803 advcl add,introduces
R6604 T21810 T21809 mark if,add
R6605 T21811 T21809 nsubj they,add
R6606 T21812 T21809 advmod significantly,add
R6607 T21813 T21809 prep to,add
R6608 T21814 T21815 det the,model
R6609 T21815 T21813 pobj model,to
R6610 T21816 T21815 amod overall,model
R6611 T21817 T21815 compound QTL,model
R6612 T21818 T21777 punct .,employed
R6613 T21820 T21821 det The,procedure
R6614 T21821 T21824 nsubj procedure,makes
R6615 T21822 T21823 compound model,selection
R6616 T21823 T21821 compound selection,procedure
R6617 T21825 T21824 dobj use,makes
R6618 T21826 T21824 prep of,makes
R6619 T21827 T21828 amod forward,regression
R6620 T21828 T21830 compound regression,techniques
R6621 T21829 T21828 amod stepwise,regression
R6622 T21830 T21826 pobj techniques,of
R6623 T21831 T21832 aux to,determine
R6624 T21832 T21824 advcl determine,makes
R6625 T21833 T21834 mark whether,is
R6626 T21834 T21832 ccomp is,determine
R6627 T21835 T21834 nsubj it,is
R6628 T21836 T21834 acomp beneficial,is
R6629 T21837 T21838 aux to,include
R6630 T21838 T21836 xcomp include,beneficial
R6631 T21839 T21840 det the,terms
R6632 T21840 T21838 dobj terms,include
R6633 T21841 T21842 compound sex,interaction
R6634 T21842 T21840 compound interaction,terms
R6635 T21843 T21842 punct -,interaction
R6636 T21844 T21838 punct ", ",include
R6637 T21845 T21838 advcl conditional,include
R6638 T21846 T21845 prep on,conditional
R6639 T21847 T21846 pcomp realizing,on
R6640 T21848 T21849 det a,effect
R6641 T21849 T21847 dobj effect,realizing
R6642 T21850 T21849 amod significant,effect
R6643 T21851 T21849 amod additive,effect
R6644 T21852 T21853 punct (,0.001
R6645 T21853 T21824 parataxis 0.001,makes
R6646 T21854 T21853 nsubj p,0.001
R6647 T21855 T21853 punct <,0.001
R6648 T21856 T21853 punct ),0.001
R6649 T21857 T21824 punct .,makes
R6650 T21859 T21860 advmod That,is
R6651 T21860 T21861 advmod is,fitted
R6652 T21862 T21861 punct ", ",fitted
R6653 T21863 T21864 det the,data
R6654 T21864 T21861 nsubjpass data,fitted
R6655 T21865 T21861 auxpass are,fitted
R6656 T21866 T21861 prep to,fitted
R6657 T21867 T21866 pobj Equation,to
R6658 T21868 T21867 nummod 4,Equation
R6659 T21869 T21861 prep for,fitted
R6660 T21870 T21871 det a,marker
R6661 T21871 T21869 pobj marker,for
R6662 T21872 T21871 amod given,marker
R6663 T21873 T21861 punct ", ",fitted
R6664 T21874 T21861 cc and,fitted
R6665 T21875 T21876 mark if,is
R6666 T21876 T21880 advcl is,attempt
R6667 T21877 T21878 det the,term
R6668 T21878 T21876 nsubj term,is
R6669 T21879 T21878 compound add,term
R6670 T21880 T21861 conj attempt,fitted
R6671 T21881 T21876 acomp significant,is
R6672 T21882 T21876 prep at,is
R6673 T21883 T21884 det the,level
R6674 T21884 T21882 pobj level,at
R6675 T21885 T21884 nummod 0.001,level
R6676 T21886 T21884 compound significance,level
R6677 T21887 T21880 punct ", ",attempt
R6678 T21888 T21880 advmod then,attempt
R6679 T21889 T21880 nsubj we,attempt
R6680 T21890 T21891 aux to,add
R6681 T21891 T21880 xcomp add,attempt
R6682 T21892 T21893 det the,term
R6683 T21893 T21891 dobj term,add
R6684 T21894 T21893 compound sex*add,term
R6685 T21895 T21891 prep into,add
R6686 T21896 T21897 det the,model
R6687 T21897 T21895 pobj model,into
R6688 T21898 T21861 punct .,fitted
R6689 T21900 T21901 det The,term
R6690 T21901 T21903 nsubjpass term,retained
R6691 T21902 T21901 compound sex*add,term
R6692 T21904 T21903 auxpass is,retained
R6693 T21905 T21903 prep in,retained
R6694 T21906 T21907 det the,model
R6695 T21907 T21905 pobj model,in
R6696 T21908 T21909 mark if,is
R6697 T21909 T21903 advcl is,retained
R6698 T21910 T21911 det the,criterion
R6699 T21911 T21909 nsubj criterion,is
R6700 T21912 T21911 amod Bayesian,criterion
R6701 T21913 T21911 compound information,criterion
R6702 T21914 T21911 punct (,criterion
R6703 T21915 T21911 appos BIC,criterion
R6704 T21916 T21911 punct ),criterion
R6705 T21917 T21911 prep for,criterion
R6706 T21918 T21919 det this,model
R6707 T21919 T21917 pobj model,for
R6708 T21920 T21909 acomp smaller,is
R6709 T21921 T21920 prep than,smaller
R6710 T21922 T21923 det the,BIC
R6711 T21923 T21921 pobj BIC,than
R6712 T21924 T21923 prep for,BIC
R6713 T21925 T21924 pobj Equation,for
R6714 T21926 T21925 nummod 4,Equation
R6715 T21927 T21903 punct .,retained
R6716 T21929 T21930 mark If,included
R6717 T21930 T21933 advcl included,use
R6718 T21931 T21930 nsubjpass sex*add,included
R6719 T21932 T21930 auxpass is,included
R6720 T21934 T21930 prep in,included
R6721 T21935 T21936 det the,model
R6722 T21936 T21934 pobj model,in
R6723 T21937 T21930 prep as,included
R6724 T21938 T21939 det a,result
R6725 T21939 T21937 pobj result,as
R6726 T21940 T21939 prep of,result
R6727 T21941 T21942 det this,procedure
R6728 T21942 T21940 pobj procedure,of
R6729 T21943 T21933 punct ", ",use
R6730 T21944 T21933 advmod then,use
R6731 T21945 T21933 nsubj we,use
R6732 T21946 T21933 advmod again,use
R6733 T21947 T21933 dobj BIC,use
R6734 T21948 T21949 aux to,consider
R6735 T21949 T21933 advcl consider,use
R6736 T21950 T21949 xcomp including,consider
R6737 T21951 T21952 det the,term
R6738 T21952 T21950 dobj term,including
R6739 T21953 T21952 compound sex*dom,term
R6740 T21954 T21950 prep in,including
R6741 T21955 T21956 det the,model
R6742 T21956 T21954 pobj model,in
R6743 T21957 T21933 punct .,use
R6744 T21959 T21960 aux To,determine
R6745 T21960 T21961 advcl determine,estimated
R6746 T21962 T21963 dep which,is
R6747 T21963 T21960 ccomp is,determine
R6748 T21964 T21962 prep of,which
R6749 T21965 T21966 det the,models
R6750 T21966 T21964 pobj models,of
R6751 T21967 T21966 nummod four,models
R6752 T21968 T21969 punct (,6
R6753 T21969 T21966 parataxis 6,models
R6754 T21970 T21969 nmod Equations,6
R6755 T21971 T21969 nummod 2,6
R6756 T21972 T21969 punct ", ",6
R6757 T21973 T21969 nummod 4,6
R6758 T21974 T21969 punct ", ",6
R6759 T21975 T21969 punct ", ",6
R6760 T21976 T21969 cc and,6
R6761 T21977 T21978 det the,selection
R6762 T21978 T21969 conj selection,6
R6763 T21979 T21978 compound model,selection
R6764 T21980 T21969 punct ),6
R6765 T21981 T21963 acomp optimal,is
R6766 T21982 T21961 punct ", ",estimated
R6767 T21983 T21961 nsubj we,estimated
R6768 T21984 T21961 advmod empirically,estimated
R6769 T21985 T21986 det the,FDR
R6770 T21986 T21961 dobj FDR,estimated
R6771 T21987 T21961 prep for,estimated
R6772 T21988 T21989 det each,model
R6773 T21989 T21987 pobj model,for
R6774 T21990 T21961 prep over,estimated
R6775 T21991 T21992 det a,set
R6776 T21992 T21990 pobj set,over
R6777 T21993 T21992 prep of,set
R6778 T21994 T21995 nummod "3,000",genes
R6779 T21995 T21993 pobj genes,of
R6780 T21996 T21997 advmod randomly,selected
R6781 T21997 T21995 acl selected,genes
R6782 T21998 T21997 prep from,selected
R6783 T21999 T22000 det the,set
R6784 T22000 T21998 pobj set,from
R6785 T22001 T22000 prep of,set
R6786 T22002 T22003 det all,genes
R6787 T22003 T22001 pobj genes,of
R6788 T22004 T22000 acl detected,set
R6789 T22005 T22006 mark as,expressed
R6790 T22006 T22004 advcl expressed,detected
R6791 T22007 T22006 prep in,expressed
R6792 T22008 T22009 det the,samples
R6793 T22009 T22007 pobj samples,in
R6794 T22010 T22009 compound liver,samples
R6795 T22011 T21961 punct .,estimated
R6796 T22013 T22014 prep For,fitted
R6797 T22015 T22016 det each,gene
R6798 T22016 T22013 pobj gene,For
R6799 T22017 T22013 cc and,For
R6800 T22018 T22013 conj for,For
R6801 T22019 T22020 det each,marker
R6802 T22020 T22018 pobj marker,for
R6803 T22021 T22014 nsubj we,fitted
R6804 T22022 T22014 dobj each,fitted
R6805 T22023 T22022 prep of,each
R6806 T22024 T22025 det the,models
R6807 T22025 T22023 pobj models,of
R6808 T22026 T22025 nummod four,models
R6809 T22027 T22014 prep to,fitted
R6810 T22028 T22029 det the,data
R6811 T22029 T22027 pobj data,to
R6812 T22030 T22014 punct .,fitted
R6813 T22032 T22033 nsubj We,performed
R6814 T22034 T22035 det this,analysis
R6815 T22035 T22033 dobj analysis,performed
R6816 T22036 T22035 amod same,analysis
R6817 T22037 T22033 prep on,performed
R6818 T22038 T22039 nummod ten,sets
R6819 T22039 T22037 pobj sets,on
R6820 T22040 T22039 amod separate,sets
R6821 T22041 T22039 compound permutation,sets
R6822 T22042 T22043 prep in,permuted
R6823 T22043 T22039 relcl permuted,sets
R6824 T22044 T22042 pobj which,in
R6825 T22045 T22043 nsubjpass each,permuted
R6826 T22046 T22045 prep of,each
R6827 T22047 T22048 det the,vectors
R6828 T22048 T22046 pobj vectors,of
R6829 T22049 T22048 nummod "3,000",vectors
R6830 T22050 T22051 compound gene,expression
R6831 T22051 T22048 compound expression,vectors
R6832 T22052 T22048 compound trait,vectors
R6833 T22053 T22043 auxpass was,permuted
R6834 T22054 T22055 amod such,preserved
R6835 T22055 T22043 ccomp preserved,permuted
R6836 T22056 T22055 mark that,preserved
R6837 T22057 T22058 det the,structure
R6838 T22058 T22055 nsubjpass structure,preserved
R6839 T22059 T22058 compound correlation,structure
R6840 T22060 T22058 prep among,structure
R6841 T22061 T22062 det the,genes
R6842 T22062 T22060 pobj genes,among
R6843 T22063 T22055 auxpass was,preserved
R6844 T22064 T22033 punct .,performed
R6845 T22066 T22067 det The,FDR
R6846 T22067 T22068 nsubjpass FDR,computed
R6847 T22069 T22067 prep for,FDR
R6848 T22070 T22071 det a,threshold
R6849 T22071 T22069 pobj threshold,for
R6850 T22072 T22071 amod given,threshold
R6851 T22073 T22071 compound LOD,threshold
R6852 T22074 T22071 compound score,threshold
R6853 T22075 T22068 auxpass was,computed
R6854 T22076 T22068 advmod then,computed
R6855 T22077 T22068 prep as,computed
R6856 T22078 T22079 det the,ratio
R6857 T22079 T22077 pobj ratio,as
R6858 T22080 T22079 prep of,ratio
R6859 T22081 T22082 det the,number
R6860 T22082 T22080 pobj number,of
R6861 T22083 T22082 amod mean,number
R6862 T22084 T22082 prep of,number
R6863 T22085 T22084 pobj QTL,of
R6864 T22086 T22085 acl detected,QTL
R6865 T22087 T22086 prep in,detected
R6866 T22088 T22089 det the,datasets
R6867 T22089 T22087 pobj datasets,in
R6868 T22090 T22089 amod permuted,datasets
R6869 T22091 T22092 punct (,mean
R6870 T22092 T22082 parataxis mean,number
R6871 T22093 T22092 det the,mean
R6872 T22094 T22092 acl taken,mean
R6873 T22095 T22094 prep over,taken
R6874 T22096 T22097 det the,datasets
R6875 T22097 T22095 pobj datasets,over
R6876 T22098 T22097 nummod ten,datasets
R6877 T22099 T22097 amod permuted,datasets
R6878 T22100 T22092 punct ),mean
R6879 T22101 T22082 cc and,number
R6880 T22102 T22103 det the,number
R6881 T22103 T22082 conj number,number
R6882 T22104 T22103 amod total,number
R6883 T22105 T22103 prep of,number
R6884 T22106 T22105 pobj QTL,of
R6885 T22107 T22103 acl detected,number
R6886 T22108 T22107 prep in,detected
R6887 T22109 T22110 det the,dataset
R6888 T22110 T22108 pobj dataset,in
R6889 T22111 T22110 amod observed,dataset
R6890 T22112 T22113 nummod "3,000",gene
R6891 T22113 T22110 compound gene,dataset
R6892 T22114 T22113 punct -,gene
R6893 T22115 T22068 punct .,computed
R6894 T22117 T22118 nsubj We,generated
R6895 T22119 T22118 advmod then,generated
R6896 T22120 T22121 amod ROC,like
R6897 T22121 T22123 amod like,curves
R6898 T22122 T22121 punct -,like
R6899 T22123 T22118 dobj curves,generated
R6900 T22124 T22118 prep by,generated
R6901 T22125 T22124 pcomp varying,by
R6902 T22126 T22127 det the,threshold
R6903 T22127 T22125 dobj threshold,varying
R6904 T22128 T22127 compound LOD,threshold
R6905 T22129 T22127 compound score,threshold
R6906 T22130 T22125 punct ", ",varying
R6907 T22131 T22125 advcl resulting,varying
R6908 T22132 T22131 prep in,resulting
R6909 T22133 T22134 det a,range
R6910 T22134 T22132 pobj range,in
R6911 T22135 T22134 prep of,range
R6912 T22136 T22135 pobj FDRs,of
R6913 T22137 T22138 punct (,to
R6914 T22138 T22134 parataxis to,range
R6915 T22139 T22138 prep from,to
R6916 T22140 T22141 nummod 0,%
R6917 T22141 T22139 pobj %,from
R6918 T22142 T22143 amod more,50
R6919 T22143 T22145 nummod 50,%
R6920 T22144 T22143 quantmod than,50
R6921 T22145 T22138 pobj %,to
R6922 T22146 T22138 punct ),to
R6923 T22147 T22118 punct .,generated
R6924 T22149 T22150 aux To,simplify
R6925 T22150 T22151 advcl simplify,considered
R6926 T22152 T22153 det this,type
R6927 T22153 T22150 dobj type,simplify
R6928 T22154 T22153 prep of,type
R6929 T22155 T22154 pobj summary,of
R6930 T22156 T22151 punct ", ",considered
R6931 T22157 T22151 nsubj we,considered
R6932 T22158 T22159 det no,more
R6933 T22159 T22151 dobj more,considered
R6934 T22160 T22159 prep than,more
R6935 T22161 T22162 nummod one,QTL
R6936 T22162 T22160 pobj QTL,than
R6937 T22163 T22162 prep per,QTL
R6938 T22164 T22163 pobj chromosome,per
R6939 T22165 T22164 prep per,chromosome
R6940 T22166 T22167 compound gene,expression
R6941 T22167 T22168 compound expression,trait
R6942 T22168 T22165 pobj trait,per
R6943 T22169 T22151 prep by,considered
R6944 T22170 T22169 pcomp considering,by
R6945 T22171 T22172 advmod only,QTL
R6946 T22172 T22170 dobj QTL,considering
R6947 T22173 T22172 det the,QTL
R6948 T22174 T22170 prep with,considering
R6949 T22175 T22176 det the,score
R6950 T22176 T22174 pobj score,with
R6951 T22177 T22176 compound max,score
R6952 T22178 T22176 compound LOD,score
R6953 T22179 T22176 prep on,score
R6954 T22180 T22181 det each,chromosome
R6955 T22181 T22179 pobj chromosome,on
R6956 T22182 T22181 prep for,chromosome
R6957 T22183 T22184 det each,trait
R6958 T22184 T22182 pobj trait,for
R6959 T22185 T22151 punct .,considered
R6960 T22187 T22188 det The,curves
R6961 T22188 T22190 nsubjpass curves,shown
R6962 T22189 T22188 compound ROC,curves
R6963 T22191 T22188 prep for,curves
R6964 T22192 T22191 pobj each,for
R6965 T22193 T22192 prep of,each
R6966 T22194 T22195 det the,models
R6967 T22195 T22193 pobj models,of
R6968 T22196 T22195 nummod four,models
R6969 T22197 T22190 auxpass are,shown
R6970 T22198 T22190 prep in,shown
R6971 T22199 T22200 compound Figure,S1
R6972 T22200 T22198 pobj S1,in
R6973 T22201 T22190 punct ", ",shown
R6974 T22202 T22203 mark with,corresponding
R6975 T22203 T22190 advcl corresponding,shown
R6976 T22204 T22205 det the,curve
R6977 T22205 T22203 nsubj curve,corresponding
R6978 T22206 T22205 amod black,curve
R6979 T22207 T22203 prep to,corresponding
R6980 T22208 T22207 pobj Equation,to
R6981 T22209 T22208 nummod 2,Equation
R6982 T22210 T22203 punct ", ",corresponding
R6983 T22211 T22212 det the,curve
R6984 T22212 T22214 nsubj curve,corresponding
R6985 T22213 T22212 amod blue,curve
R6986 T22214 T22203 conj corresponding,corresponding
R6987 T22215 T22214 prep to,corresponding
R6988 T22216 T22215 pobj Equation,to
R6989 T22217 T22216 nummod 4,Equation
R6990 T22218 T22214 punct ", ",corresponding
R6991 T22219 T22220 det the,curve
R6992 T22220 T22222 nsubj curve,corresponding
R6993 T22221 T22220 amod red,curve
R6994 T22222 T22214 conj corresponding,corresponding
R6995 T22223 T22222 prep to,corresponding
R6996 T22224 T22223 pobj Equation,to
R6997 T22225 T22224 nummod 6,Equation
R6998 T22226 T22222 punct ", ",corresponding
R6999 T22227 T22222 cc and,corresponding
R7000 T22228 T22229 det the,curve
R7001 T22229 T22231 nsubj curve,corresponding
R7002 T22230 T22229 amod green,curve
R7003 T22231 T22222 conj corresponding,corresponding
R7004 T22232 T22231 prep to,corresponding
R7005 T22233 T22234 det the,procedure
R7006 T22234 T22232 pobj procedure,to
R7007 T22235 T22236 compound model,selection
R7008 T22236 T22234 compound selection,procedure
R7009 T22237 T22190 punct .,shown
R7010 T22239 T22240 nsubj It,is
R7011 T22241 T22240 acomp clear,is
R7012 T22242 T22240 prep from,is
R7013 T22243 T22244 det the,ROC
R7014 T22244 T22242 pobj ROC,from
R7015 T22245 T22244 nmod curves,ROC
R7016 T22246 T22247 mark that,are
R7017 T22247 T22240 ccomp are,is
R7018 T22248 T22249 det the,terms
R7019 T22249 T22247 nsubj terms,are
R7020 T22250 T22249 nmod sex,terms
R7021 T22251 T22250 cc and,sex
R7022 T22252 T22253 compound sex,interaction
R7023 T22253 T22250 conj interaction,sex
R7024 T22254 T22253 punct -,interaction
R7025 T22255 T22247 acomp significant,are
R7026 T22256 T22255 prep in,significant
R7027 T22257 T22258 det the,dataset
R7028 T22258 T22256 pobj dataset,in
R7029 T22259 T22260 compound gene,expression
R7030 T22260 T22258 compound expression,dataset
R7031 T22261 T22240 punct .,is
R7032 T22263 T22264 prep For,note
R7033 T22265 T22263 pobj example,For
R7034 T22266 T22264 punct ", ",note
R7035 T22267 T22264 prep at,note
R7036 T22268 T22269 det an,FDR
R7037 T22269 T22267 pobj FDR,at
R7038 T22270 T22269 prep of,FDR
R7039 T22271 T22272 nummod 5,%
R7040 T22272 T22270 pobj %,of
R7041 T22273 T22264 nsubj we,note
R7042 T22274 T22275 mark that,detected
R7043 T22275 T22264 ccomp detected,note
R7044 T22276 T22277 nummod 800,QTLs
R7045 T22277 T22275 nsubjpass QTLs,detected
R7046 T22278 T22275 auxpass were,detected
R7047 T22279 T22275 prep in,detected
R7048 T22280 T22281 det the,set
R7049 T22281 T22279 pobj set,in
R7050 T22282 T22281 prep of,set
R7051 T22283 T22284 nummod "3,000",genes
R7052 T22284 T22282 pobj genes,of
R7053 T22285 T22281 prep for,set
R7054 T22286 T22285 pobj model,for
R7055 T22287 T22286 nummod 1,model
R7056 T22288 T22275 punct ", ",detected
R7057 T22289 T22290 mark while,detected
R7058 T22290 T22275 advcl detected,detected
R7059 T22291 T22292 nummod 968,QTLs
R7060 T22292 T22290 nsubjpass QTLs,detected
R7061 T22293 T22294 punct (,increase
R7062 T22294 T22291 parataxis increase,968
R7063 T22295 T22296 nummod 21,%
R7064 T22296 T22294 compound %,increase
R7065 T22297 T22294 punct ),increase
R7066 T22298 T22291 cc and,968
R7067 T22299 T22291 conj "1,159",968
R7068 T22300 T22301 punct (,increase
R7069 T22301 T22299 parataxis increase,"1,159"
R7070 T22302 T22303 nummod 45,%
R7071 T22303 T22301 compound %,increase
R7072 T22304 T22301 punct ),increase
R7073 T22305 T22290 auxpass were,detected
R7074 T22306 T22290 prep for,detected
R7075 T22307 T22308 nmod Equations,4
R7076 T22308 T22306 pobj 4,for
R7077 T22309 T22308 cc and,4
R7078 T22310 T22308 conj 6,4
R7079 T22311 T22290 punct ", ",detected
R7080 T22312 T22290 advmod respectively,detected
R7081 T22313 T22264 punct .,note
R7082 T22315 T22316 det These,results
R7083 T22316 T22317 nsubj results,demonstrate
R7084 T22318 T22319 advmod significantly,increased
R7085 T22319 T22320 amod increased,power
R7086 T22320 T22317 dobj power,demonstrate
R7087 T22321 T22322 aux to,detect
R7088 T22322 T22320 acl detect,power
R7089 T22323 T22322 dobj QTLs,detect
R7090 T22324 T22325 advmod when,taken
R7091 T22325 T22322 advcl taken,detect
R7092 T22326 T22325 nsubjpass sex,taken
R7093 T22327 T22325 auxpass is,taken
R7094 T22328 T22325 prep into,taken
R7095 T22329 T22328 pobj account,into
R7096 T22330 T22317 punct .,demonstrate
R7097 T22332 T22333 nsubj We,note
R7098 T22334 T22333 advmod further,note
R7099 T22335 T22336 mark that,captures
R7100 T22336 T22333 ccomp captures,note
R7101 T22337 T22338 det the,procedure
R7102 T22338 T22336 nsubj procedure,captures
R7103 T22339 T22340 amod stepwise,selection
R7104 T22340 T22338 compound selection,procedure
R7105 T22341 T22342 amod more,information
R7106 T22342 T22336 dobj information,captures
R7107 T22343 T22342 prep than,information
R7108 T22344 T22343 pobj Equation,than
R7109 T22345 T22344 nummod 4,Equation
R7110 T22346 T22336 punct ", ",captures
R7111 T22347 T22336 advcl indicating,captures
R7112 T22348 T22349 det a,signature
R7113 T22349 T22347 dobj signature,indicating
R7114 T22350 T22349 amod significant,signature
R7115 T22351 T22349 compound interaction,signature
R7116 T22352 T22349 prep in,signature
R7117 T22353 T22354 det this,dataset
R7118 T22354 T22352 pobj dataset,in
R7119 T22355 T22347 cc and,indicating
R7120 T22356 T22357 advmod also,demonstrating
R7121 T22357 T22347 conj demonstrating,indicating
R7122 T22358 T22359 mark that,is
R7123 T22359 T22357 ccomp is,demonstrating
R7124 T22360 T22361 det this,procedure
R7125 T22361 T22359 nsubj procedure,is
R7126 T22362 T22361 amod simple,procedure
R7127 T22363 T22361 amod statistical,procedure
R7128 T22364 T22359 acomp capable,is
R7129 T22365 T22364 prep of,capable
R7130 T22366 T22365 pcomp identifying,of
R7131 T22367 T22368 amod significant,events
R7132 T22368 T22366 dobj events,identifying
R7133 T22369 T22368 compound interaction,events
R7134 T22370 T22371 advmod even,at
R7135 T22371 T22366 prep at,identifying
R7136 T22372 T22373 amod conservative,thresholds
R7137 T22373 T22371 pobj thresholds,at
R7138 T22374 T22373 compound FDR,thresholds
R7139 T22375 T22333 punct .,note
R7140 T22377 T22378 advmod Finally,is
R7141 T22379 T22378 punct ", ",is
R7142 T22380 T22378 nsubj it,is
R7143 T22381 T22378 prep of,is
R7144 T22382 T22383 amod particular,note
R7145 T22383 T22381 pobj note,of
R7146 T22384 T22385 mark that,performed
R7147 T22385 T22378 ccomp performed,is
R7148 T22386 T22385 nsubj Equation,performed
R7149 T22387 T22386 nummod 4,Equation
R7150 T22388 T22385 advmod better,performed
R7151 T22389 T22388 prep than,better
R7152 T22390 T22389 pobj Equation,than
R7153 T22391 T22390 nummod 6,Equation
R7154 T22392 T22390 punct ", ",Equation
R7155 T22393 T22394 det the,model
R7156 T22394 T22390 appos model,Equation
R7157 T22395 T22396 dep that,incorporated
R7158 T22396 T22394 relcl incorporated,model
R7159 T22397 T22398 det the,terms
R7160 T22398 T22396 dobj terms,incorporated
R7161 T22399 T22398 compound interaction,terms
R7162 T22400 T22396 prep at,incorporated
R7163 T22401 T22402 det all,times
R7164 T22402 T22400 pobj times,at
R7165 T22403 T22378 punct .,is
R7166 T22405 T22406 advmod That,is
R7167 T22406 T22407 advmod is,was
R7168 T22408 T22407 punct ", ",was
R7169 T22409 T22410 mark despite,being
R7170 T22410 T22407 advcl being,was
R7171 T22411 T22410 expl there,being
R7172 T22412 T22413 det a,signature
R7173 T22413 T22410 attr signature,being
R7174 T22414 T22413 amod significant,signature
R7175 T22415 T22413 compound interaction,signature
R7176 T22416 T22407 punct ", ",was
R7177 T22417 T22418 det the,signature
R7178 T22418 T22407 nsubj signature,was
R7179 T22419 T22407 neg not,was
R7180 T22420 T22407 acomp large,was
R7181 T22421 T22420 advmod enough,large
R7182 T22422 T22423 aux to,justify
R7183 T22423 T22420 xcomp justify,large
R7184 T22424 T22423 xcomp including,justify
R7185 T22425 T22426 compound interaction,terms
R7186 T22426 T22424 dobj terms,including
R7187 T22427 T22424 prep for,including
R7188 T22428 T22429 det every,trait
R7189 T22429 T22427 pobj trait,for
R7190 T22430 T22429 compound expression,trait
R7191 T22431 T22427 cc and,for
R7192 T22432 T22427 conj at,for
R7193 T22433 T22434 det every,marker
R7194 T22434 T22432 pobj marker,at
R7195 T22435 T22434 acl tested,marker
R7196 T22436 T22407 punct .,was
R7197 T22438 T22439 det This,fact
R7198 T22439 T22440 nsubj fact,motivated
R7199 T22441 T22442 det the,need
R7200 T22442 T22440 dobj need,motivated
R7201 T22443 T22444 aux to,employ
R7202 T22444 T22442 acl employ,need
R7203 T22445 T22446 det the,procedure
R7204 T22446 T22444 dobj procedure,employ
R7205 T22447 T22448 amod forward,regression
R7206 T22448 T22446 compound regression,procedure
R7207 T22449 T22440 punct ", ",motivated
R7241 T23070 T23071 amod Additional,statistics
R7242 T23072 T23071 punct .,statistics
R7243 T23074 T23075 prep For,computed
R7244 T23076 T23077 det each,oligonucleotides
R7245 T23077 T23074 pobj oligonucleotides,For
R7246 T23078 T23077 nummod "23,574",oligonucleotides
R7247 T23079 T23077 acl represented,oligonucleotides
R7248 T23080 T23079 prep on,represented
R7249 T23081 T23082 det the,array
R7250 T23082 T23080 pobj array,on
R7251 T23083 T23075 punct ", ",computed
R7252 T23084 T23075 nsubj we,computed
R7253 T23085 T23086 det a,analysis
R7254 T23086 T23075 dobj analysis,computed
R7255 T23087 T23088 amod linear,regression
R7256 T23088 T23086 compound regression,analysis
R7257 T23089 T23090 aux to,test
R7258 T23090 T23075 advcl test,computed
R7259 T23091 T23090 prep for,test
R7260 T23092 T23093 det a,correlation
R7261 T23093 T23091 pobj correlation,for
R7262 T23094 T23093 prep between,correlation
R7263 T23095 T23096 det the,trait
R7264 T23096 T23094 pobj trait,between
R7265 T23097 T23096 punct “,trait
R7266 T23098 T23099 amod gonadal,mass
R7267 T23099 T23096 appos mass,trait
R7268 T23100 T23099 compound fat,mass
R7269 T23101 T23096 punct ”,trait
R7270 T23102 T23096 cc and,trait
R7271 T23103 T23104 det each,transcript
R7272 T23104 T23096 conj transcript,trait
R7273 T23105 T23075 punct .,computed
R7274 T23107 T23108 advcl Similar,employed
R7275 T23109 T23107 prep to,Similar
R7276 T23110 T23111 poss our,method
R7277 T23111 T23109 pobj method,to
R7278 T23112 T23111 prep of,method
R7279 T23113 T23112 pcomp calculating,of
R7280 T23114 T23113 dobj linkage,calculating
R7281 T23115 T23108 punct ", ",employed
R7282 T23116 T23108 nsubj we,employed
R7283 T23117 T23118 det a,procedure
R7284 T23118 T23108 dobj procedure,employed
R7285 T23119 T23120 amod stepwise,regression
R7286 T23120 T23118 compound regression,procedure
R7287 T23121 T23120 amod linear,regression
R7288 T23122 T23108 advcl using,employed
R7289 T23123 T23122 dobj equations,using
R7290 T23124 T23123 prep of,equations
R7291 T23125 T23126 det the,form
R7292 T23126 T23124 pobj form,of
R7293 T23127 T23108 cc or,employed
R7294 T23128 T23108 conj compared,employed
R7295 T23129 T23128 prep to,compared
R7296 T23130 T23131 det the,model
R7297 T23131 T23129 pobj model,to
R7298 T23132 T23131 amod null,model
R7299 T23133 T23134 advmod where,is
R7300 T23134 T23131 relcl is,model
R7301 T23135 T23134 nsubj β0,is
R7302 T23136 T23137 det the,intercept
R7303 T23137 T23134 attr intercept,is
R7304 T23138 T23134 punct ", ",is
R7305 T23139 T23134 cc and,is
R7306 T23140 T23141 nsubj β1,represent
R7307 T23141 T23134 conj represent,is
R7308 T23142 T23140 punct ", ",β1
R7309 T23143 T23140 conj β2,β1
R7310 T23144 T23143 punct ", ",β2
R7311 T23145 T23143 cc and,β2
R7312 T23146 T23143 conj β3,β2
R7313 T23147 T23148 det the,coefficients
R7314 T23148 T23141 dobj coefficients,represent
R7315 T23149 T23148 compound regression,coefficients
R7316 T23150 T23148 prep of,coefficients
R7317 T23151 T23152 poss their,terms
R7318 T23152 T23150 pobj terms,of
R7319 T23153 T23152 amod respective,terms
R7320 T23154 T23108 punct .,employed
R7321 T23156 T23157 prep As,retained
R7322 T23158 T23156 pcomp before,As
R7323 T23159 T23157 punct ", ",retained
R7324 T23160 T23161 det the,parameter
R7325 T23161 T23157 nsubjpass parameter,retained
R7326 T23162 T23161 punct “,parameter
R7327 T23163 T23161 appos sex,parameter
R7328 T23164 T23165 punct *,gene
R7329 T23165 T23163 prep gene,sex
R7330 T23166 T23157 punct ”,retained
R7331 T23167 T23157 auxpass is,retained
R7332 T23168 T23157 advmod only,retained
R7333 T23169 T23170 mark if,improves
R7334 T23170 T23157 advcl improves,retained
R7335 T23171 T23170 nsubj it,improves
R7336 T23172 T23170 advmod significantly,improves
R7337 T23173 T23174 det the,fit
R7338 T23174 T23170 dobj fit,improves
R7339 T23175 T23174 prep of,fit
R7340 T23176 T23177 det the,model
R7341 T23177 T23175 pobj model,of
R7342 T23178 T23157 punct .,retained
R7343 T23180 T23181 det The,threshold
R7344 T23181 T23185 nsubjpass threshold,calculated
R7345 T23182 T23183 compound p,value
R7346 T23183 T23181 compound value,threshold
R7347 T23184 T23183 punct -,value
R7348 T23186 T23181 prep for,threshold
R7349 T23187 T23188 amod significant,correlation
R7350 T23188 T23186 pobj correlation,for
R7351 T23189 T23185 auxpass is,calculated
R7352 T23190 T23185 prep by,calculated
R7353 T23191 T23192 det an,test
R7354 T23192 T23190 pobj test,by
R7355 T23193 T23192 compound F,test
R7356 T23194 T23192 punct ", ",test
R7357 T23195 T23196 dep which,compares
R7358 T23196 T23192 relcl compares,test
R7359 T23197 T23198 det the,model
R7360 T23198 T23196 dobj model,compares
R7361 T23199 T23198 amod appropriate,model
R7362 T23200 T23201 punct (,7
R7363 T23201 T23198 parataxis 7,model
R7364 T23202 T23201 nmod Equation,7
R7365 T23203 T23201 cc or,7
R7366 T23204 T23201 conj 8,7
R7367 T23205 T23201 punct ),7
R7368 T23206 T23196 prep to,compares
R7369 T23207 T23208 det the,model
R7370 T23208 T23206 pobj model,to
R7371 T23209 T23208 amod null,model
R7372 T23210 T23211 punct (,Equation
R7373 T23211 T23208 parataxis Equation,model
R7374 T23212 T23211 nummod 9,Equation
R7375 T23213 T23211 punct ),Equation
R7376 T23214 T23185 punct .,calculated
R7377 T23216 T23217 prep As,addressed
R7378 T23218 T23216 pcomp before,As
R7379 T23219 T23217 punct ", ",addressed
R7380 T23220 T23221 amod multiple,testing
R7381 T23221 T23217 nsubjpass testing,addressed
R7382 T23222 T23217 auxpass was,addressed
R7383 T23223 T23217 prep with,addressed
R7384 T23224 T23223 pobj use,with
R7385 T23225 T23224 prep of,use
R7386 T23226 T23227 det the,FDR
R7387 T23227 T23225 pobj FDR,of
R7388 T23228 T23217 punct ", ",addressed
R7389 T23229 T23217 advcl ranking,addressed
R7390 T23230 T23231 det the,values
R7391 T23231 T23229 dobj values,ranking
R7392 T23232 T23231 compound p,values
R7393 T23233 T23231 punct -,values
R7394 T23234 T23231 acl obtained,values
R7395 T23235 T23234 prep from,obtained
R7396 T23236 T23237 det the,tests
R7397 T23237 T23235 pobj tests,from
R7398 T23238 T23237 amod above,tests
R7399 T23239 T23237 compound F,tests
R7400 T23240 T23229 cc and,ranking
R7401 T23241 T23229 conj setting,ranking
R7402 T23242 T23243 nsubj α,0.01
R7403 T23243 T23241 ccomp 0.01,setting
R7404 T23244 T23243 punct =,0.01
R7405 T23245 T23217 punct .,addressed
R7406 T23247 T23248 nsubj Genes,generated
R7407 T23249 T23247 acl correlated,Genes
R7408 T23250 T23249 prep with,correlated
R7409 T23251 T23252 det the,trait
R7410 T23252 T23250 pobj trait,with
R7411 T23253 T23254 amod gonadal,mass
R7412 T23254 T23252 compound mass,trait
R7413 T23255 T23254 compound fat,mass
R7414 T23256 T23257 amod several,eQTLs
R7415 T23257 T23248 dobj eQTLs,generated
R7416 T23258 T23257 amod significant,eQTLs
R7417 T23259 T23248 punct .,generated
R7418 T23261 T23262 prep In,compared
R7419 T23263 T23261 pobj order,In
R7420 T23264 T23265 aux to,determine
R7421 T23265 T23263 acl determine,order
R7422 T23266 T23267 mark if,enriched
R7423 T23267 T23265 advcl enriched,determine
R7424 T23268 T23267 nsubjpass eQTLs,enriched
R7425 T23269 T23268 acl generated,eQTLs
R7426 T23270 T23269 agent by,generated
R7427 T23271 T23272 det these,genes
R7428 T23272 T23270 pobj genes,by
R7429 T23273 T23267 auxpass were,enriched
R7430 T23274 T23267 prep in,enriched
R7431 T23275 T23276 det any,locus
R7432 T23276 T23274 pobj locus,in
R7433 T23277 T23267 cc or,enriched
R7434 T23278 T23279 mark if,distributed
R7435 T23279 T23267 conj distributed,enriched
R7436 T23280 T23279 nsubjpass they,distributed
R7437 T23281 T23279 auxpass were,distributed
R7438 T23282 T23279 advmod randomly,distributed
R7439 T23283 T23262 punct ", ",compared
R7440 T23284 T23262 nsubj we,compared
R7441 T23285 T23286 det the,distribution
R7442 T23286 T23262 dobj distribution,compared
R7443 T23287 T23286 prep of,distribution
R7444 T23288 T23289 det these,eQTLs
R7445 T23289 T23287 pobj eQTLs,of
R7446 T23290 T23262 prep against,compared
R7447 T23291 T23292 det the,distribution
R7448 T23292 T23290 pobj distribution,against
R7449 T23293 T23292 prep of,distribution
R7450 T23294 T23295 det all,eQTLs
R7451 T23295 T23293 pobj eQTLs,of
R7452 T23296 T23295 compound liver,eQTLs
R7453 T23297 T23262 prep in,compared
R7454 T23298 T23299 amod overlapping,bins
R7455 T23299 T23297 pobj bins,in
R7456 T23300 T23301 nummod 6,cM
R7457 T23301 T23299 compound cM,bins
R7458 T23302 T23301 punct -,cM
R7459 T23303 T23262 prep across,compared
R7460 T23304 T23305 det the,genome
R7461 T23305 T23303 pobj genome,across
R7462 T23306 T23262 advcl using,compared
R7463 T23307 T23308 det the,test
R7464 T23308 T23306 dobj test,using
R7465 T23309 T23308 nmod Fisher,test
R7466 T23310 T23308 amod exact,test
R7467 T23311 T23262 punct .,compared
R7468 T23313 T23314 det This,test
R7469 T23314 T23315 nsubjpass test,based
R7470 T23316 T23315 auxpass is,based
R7471 T23317 T23315 prep on,based
R7472 T23318 T23319 amod exact,probabilities
R7473 T23319 T23317 pobj probabilities,on
R7474 T23320 T23319 prep from,probabilities
R7475 T23321 T23322 det a,distribution
R7476 T23322 T23320 pobj distribution,from
R7477 T23323 T23322 amod specific,distribution
R7478 T23324 T23325 punct (,distribution
R7479 T23325 T23322 parataxis distribution,distribution
R7480 T23326 T23325 amod hypergeometric,distribution
R7481 T23327 T23325 punct ),distribution
R7482 T23328 T23315 punct .,based
R7483 T23330 T23331 compound p,Values
R7484 T23331 T23333 nsubjpass Values,corrected
R7485 T23332 T23331 punct -,Values
R7486 T23334 T23331 acl obtained,Values
R7487 T23335 T23334 prep from,obtained
R7488 T23336 T23337 det this,test
R7489 T23337 T23335 pobj test,from
R7490 T23338 T23333 auxpass were,corrected
R7491 T23339 T23333 prep for,corrected
R7492 T23340 T23341 amod multiple,comparisons
R7493 T23341 T23339 pobj comparisons,for
R7494 T23342 T23333 advcl using,corrected
R7495 T23343 T23344 det a,correction
R7496 T23344 T23342 dobj correction,using
R7497 T23345 T23344 amod simple,correction
R7498 T23346 T23344 compound Bonferonni,correction
R7499 T23347 T23348 punct (,772
R7500 T23348 T23344 parataxis 772,correction
R7501 T23349 T23348 prep given,772
R7502 T23350 T23351 mark that,performed
R7503 T23351 T23349 pcomp performed,given
R7504 T23352 T23351 nsubj we,performed
R7505 T23353 T23354 nummod 772,tests
R7506 T23354 T23351 dobj tests,performed
R7507 T23355 T23351 prep across,performed
R7508 T23356 T23357 det the,genome
R7509 T23357 T23355 pobj genome,across
R7510 T23358 T23348 punct ", ",772
R7511 T23359 T23348 nummod 0.05,772
R7512 T23360 T23348 punct /,772
R7513 T23361 T23348 punct ),772
R7514 T23362 T23333 punct .,corrected
R7515 T23364 T23365 nsubjpass Loci,considered
R7516 T23366 T23364 prep with,Loci
R7517 T23367 T23366 pobj p,with
R7518 T23368 T23369 punct <,6.5
R7519 T23369 T23367 amod 6.5,p
R7520 T23370 T23369 punct ×,6.5
R7521 T23371 T23372 nummod 10,5
R7522 T23372 T23369 appos 5,6.5
R7523 T23373 T23372 punct −,5
R7524 T23374 T23367 prep by,p
R7525 T23375 T23376 nmod Fisher,test
R7526 T23376 T23374 pobj test,by
R7527 T23377 T23376 amod exact,test
R7528 T23378 T23365 auxpass were,considered
R7529 T23379 T23380 advmod significantly,enriched
R7530 T23380 T23365 oprd enriched,considered
R7531 T23381 T23380 prep for,enriched
R7532 T23382 T23381 pobj eQTLs,for
R7533 T23383 T23382 acl correlated,eQTLs
R7534 T23384 T23383 prep with,correlated
R7535 T23385 T23386 amod gonadal,mass
R7536 T23386 T23384 pobj mass,with
R7537 T23387 T23386 compound fat,mass
R7538 T23388 T23365 punct .,considered
R23 T562 T555 aux has,used
R1 T535 T539 nsubj Analysis,Reveals
R4 T540 T535 prep of,Analysis
R5 T541 T542 det a,Trait
R6 T542 T540 pobj Trait,of
R9 T545 T542 prep with,Trait
R10 T546 T547 amod Complex,Inheritance
R11 T547 T545 pobj Inheritance,with
R12 T548 T549 amod Marked,Specificity
R13 T549 T539 dobj Specificity,Reveals
R15 T553 T554 det The,integration
R16 T554 T555 nsubjpass integration,used
R17 T556 T554 prep of,integration
R18 T557 T558 compound expression,profiling
R19 T558 T556 pobj profiling,of
R20 T559 T554 prep with,integration
R21 T560 T561 compound linkage,analysis
R22 T561 T559 pobj analysis,with
R24 T563 T555 advmod increasingly,used
R25 T564 T555 auxpass been,used
R26 T565 T566 aux to,identify
R27 T566 T555 advcl identify,used
R28 T567 T566 dobj genes,identify
R29 T568 T567 acl underlying,genes
R30 T569 T570 amod complex,phenotypes
R31 T570 T568 dobj phenotypes,underlying
R32 T571 T555 punct .,used
R33 T573 T574 det The,effects
R34 T574 T575 nsubj effects,are
R35 T575 T585 ccomp are,addressed
R43 T583 T581 pobj traits,of
R44 T584 T583 amod physiological,traits
R45 T586 T587 advmod well,documented
R46 T587 T575 acomp documented,are
R47 T588 T585 punct ;,addressed
R48 T589 T585 advmod however,addressed
R49 T590 T585 punct ", ",addressed
R50 T591 T592 punct “,analyses
R51 T592 T585 nsubj analyses,addressed
R55 T596 T585 aux have,addressed
R56 T597 T585 neg not,addressed
R57 T598 T585 advmod yet,addressed
R58 T599 T600 det the,degree
R59 T600 T585 dobj degree,addressed
R60 T601 T602 prep to,affected
R61 T602 T600 relcl affected,degree
R66 T607 T602 agent by,affected
R67 T608 T607 pobj sex,by
R68 T609 T585 punct .,addressed
R69 T611 T612 nsubj We,constructed
R70 T613 T612 cc and,constructed
R71 T614 T615 advmod densely,genotyped
R72 T615 T612 conj genotyped,constructed
R73 T616 T617 det a,intercross
R74 T617 T615 dobj intercross,genotyped
R77 T620 T617 acl derived,intercross
R78 T621 T620 prep from,derived
R79 T622 T623 det the,strains
R80 T623 T621 pobj strains,from
R83 T626 T627 compound C57BL,6J
R84 T627 T623 appos 6J,strains
R86 T629 T627 cc and,6J
R87 T630 T631 compound C3H,HeJ
R88 T631 T627 conj HeJ,6J
R90 T633 T623 prep on,strains
R91 T634 T635 det an,background
R92 T635 T633 pobj background,on
R102 T645 T612 punct .,constructed
R103 T647 T648 det This,population
R104 T648 T653 nsubj population,recapitulates
R109 T654 T655 amod several,phenotypes
R110 T655 T653 dobj phenotypes,recapitulates
R115 T660 T653 punct .,recapitulates
R116 T662 T663 det The,cross
R117 T663 T664 nsubj cross,consists
R118 T665 T664 prep of,consists
R119 T666 T667 nummod 334,animals
R120 T667 T665 pobj animals,of
R121 T668 T667 prep of,animals
R122 T669 T670 det both,sexes
R123 T670 T668 pobj sexes,of
R124 T671 T664 punct ", ",consists
R125 T672 T664 advcl allowing,consists
R126 T673 T674 nsubj us,test
R127 T674 T672 ccomp test,allowing
R130 T677 T674 prep for,test
R131 T678 T679 det the,dependence
R132 T679 T677 pobj dependence,for
R133 T680 T679 prep of,dependence
R134 T681 T680 pobj linkage,of
R135 T682 T679 prep on,dependence
R136 T683 T682 pobj sex,on
R137 T684 T664 punct .,consists
R138 T686 T687 nsubj We,detected
R139 T688 T689 amod several,thousand
R140 T689 T690 nummod thousand,loci
R141 T690 T687 dobj loci,detected
R147 T696 T690 punct ", ",loci
R148 T697 T698 det a,proportion
R149 T698 T700 dep proportion,are
R151 T700 T690 relcl are,loci
R154 T703 T704 npadvmod sex,biased
R155 T704 T700 acomp biased,are
R157 T706 T687 punct .,detected
R158 T708 T709 nsubj We,used
R159 T710 T711 det these,analyses
R160 T711 T709 dobj analyses,used
R161 T712 T713 aux to,dissect
R162 T713 T709 advcl dissect,used
R163 T714 T715 det the,genetics
R164 T715 T713 dobj genetics,dissect
R165 T716 T715 prep of,genetics
R166 T717 T718 amod gonadal,mass
R167 T718 T716 pobj mass,of
R169 T720 T718 punct ", ",mass
R170 T721 T722 det a,trait
R171 T722 T718 appos trait,mass
R173 T724 T722 prep with,trait
R174 T725 T726 npadvmod sex,specific
R175 T726 T728 amod specific,regulation
R177 T728 T724 pobj regulation,with
R178 T729 T709 punct .,used
R179 T731 T732 nsubj We,present
R180 T733 T732 dobj evidence,present
R181 T734 T733 prep for,evidence
R182 T735 T736 det a,degree
R183 T736 T734 pobj degree,for
R186 T739 T736 prep of,degree
R187 T740 T741 compound sex,dependence
R188 T741 T739 pobj dependence,of
R190 T743 T741 prep on,dependence
R191 T744 T745 preconj both,cis
R192 T745 T743 pobj cis,on
R194 T747 T745 cc and,cis
R195 T748 T749 compound trans,regulation
R196 T749 T745 conj regulation,cis
R197 T750 T749 prep of,regulation
R198 T751 T752 compound gene,expression
R199 T752 T750 pobj expression,of
R200 T753 T732 punct .,present
R201 T755 T756 nsubj We,demonstrate
R202 T757 T758 advmod how,applied
R203 T758 T756 ccomp applied,demonstrate
R208 T763 T758 prep to,applied
R209 T764 T765 det the,study
R210 T765 T763 pobj study,to
R211 T766 T765 prep of,study
R212 T767 T768 det the,genetics
R213 T768 T766 pobj genetics,of
R214 T769 T768 acl underlying,genetics
R215 T770 T771 amod gonadal,mass
R216 T771 T769 dobj mass,underlying
R218 T773 T771 punct ", ",mass
R219 T774 T775 det a,trait
R220 T775 T771 appos trait,mass
R222 T777 T775 acl showing,trait
R223 T778 T779 advmod significantly,biased
R224 T779 T782 amod biased,heritability
R227 T782 T777 dobj heritability,showing
R228 T783 T756 punct .,demonstrate
R229 T785 T786 det These,data
R230 T786 T787 nsubj data,have
R231 T788 T787 dobj implications,have
R232 T789 T788 prep on,implications
R233 T790 T791 det the,effects
R234 T791 T789 pobj effects,on
R236 T793 T791 prep of,effects
R237 T794 T793 pobj sex,of
R238 T795 T791 prep on,effects
R239 T796 T797 det the,regulation
R240 T797 T795 pobj regulation,on
R242 T799 T797 prep of,regulation
R243 T800 T801 amod other,traits
R244 T801 T799 pobj traits,of
R246 T803 T787 punct .,have
R247 T534 T535 amod Genetic,Analysis
R250 T1994 T1995 nsubj Females,share
R251 T1996 T1994 cc and,Females
R252 T1997 T1994 conj males,Females
R253 T1998 T1999 advmod nearly,identical
R254 T1999 T2000 amod identical,information
R255 T2000 T1995 dobj information,share
R256 T2001 T2000 amod genetic,information
R257 T2002 T1995 punct ", ",share
R258 T2003 T1995 cc but,share
R259 T2004 T1995 conj vary,share
R260 T2005 T2004 advmod widely,vary
R261 T2006 T2004 prep with,vary
R262 T2007 T2006 pobj respect,with
R263 T2008 T2007 prep to,respect
R264 T2009 T2010 compound disease,susceptibility
R265 T2010 T2008 pobj susceptibility,to
R266 T2011 T2012 punct [,2
R267 T2012 T2004 parataxis 2,vary
R268 T2013 T2012 nummod 1,2
R269 T2014 T2012 punct ",",2
R270 T2015 T2012 punct ],2
R271 T2016 T1995 punct .,share
R272 T2018 T2019 advmod Apart,influences
R273 T2020 T2018 prep from,Apart
R274 T2021 T2022 det the,diseases
R275 T2022 T2020 pobj diseases,from
R276 T2023 T2022 amod obvious,diseases
R277 T2024 T2025 npadvmod gender,specific
R278 T2025 T2022 amod specific,diseases
R279 T2026 T2025 punct -,specific
R280 T2027 T2028 amod such,as
R281 T2028 T2022 prep as,diseases
R282 T2029 T2030 amod cervical,cancer
R283 T2030 T2028 pobj cancer,as
R284 T2031 T2029 cc or,cervical
R285 T2032 T2029 conj prostate,cervical
R286 T2033 T2019 punct ", ",influences
R287 T2034 T2019 nsubj sex,influences
R288 T2035 T2019 dobj susceptibility,influences
R289 T2036 T2035 prep to,susceptibility
R290 T2037 T2038 advmod nearly,all
R291 T2038 T2039 nummod all,diseases
R292 T2039 T2036 pobj diseases,to
R293 T2040 T2041 advmod highly,prevalent
R294 T2041 T2039 amod prevalent,diseases
R295 T2042 T2043 dep that,affect
R296 T2043 T2039 relcl affect,diseases
R297 T2044 T2045 det both,women
R298 T2045 T2043 dobj women,affect
R299 T2046 T2045 cc and,women
R300 T2047 T2045 conj men,women
R301 T2048 T2039 punct ", ",diseases
R302 T2049 T2039 prep including,diseases
R303 T2050 T2049 pobj atherosclerosis,including
R304 T2051 T2050 cc and,atherosclerosis
R305 T2052 T2050 conj diabetes,atherosclerosis
R306 T2053 T2050 cc and,atherosclerosis
R307 T2054 T2055 poss their,conditions
R308 T2055 T2050 conj conditions,atherosclerosis
R309 T2056 T2055 compound precursor,conditions
R310 T2057 T2055 prep of,conditions
R311 T2058 T2057 pobj hyperlipidemia,of
R312 T2059 T2058 punct ", ",hyperlipidemia
R313 T2060 T2058 conj obesity,hyperlipidemia
R314 T2061 T2060 punct ", ",obesity
R315 T2062 T2060 cc and,obesity
R316 T2063 T2064 compound insulin,resistance
R317 T2064 T2060 conj resistance,obesity
R318 T2065 T2019 punct .,influences
R319 T2067 T2068 nsubj These,are
R320 T2069 T2068 acomp multifactorial,are
R321 T2070 T2069 prep in,multifactorial
R322 T2071 T2072 poss their,pathogenesis
R323 T2072 T2070 pobj pathogenesis,in
R324 T2073 T2068 punct ", ",are
R325 T2074 T2068 advcl encompassing,are
R326 T2075 T2076 amod environmental,aspects
R327 T2076 T2074 dobj aspects,encompassing
R328 T2077 T2075 cc and,environmental
R329 T2078 T2075 conj behavioral,environmental
R330 T2079 T2076 punct ", ",aspects
R331 T2080 T2081 advmod as,as
R332 T2081 T2076 cc as,aspects
R333 T2082 T2081 advmod well,as
R334 T2083 T2084 amod significant,determination
R335 T2084 T2076 conj determination,aspects
R336 T2085 T2084 amod genetic,determination
R337 T2086 T2084 punct ", ",determination
R338 T2087 T2088 prep on,interact
R339 T2088 T2084 relcl interact,determination
R340 T2089 T2087 pobj which,on
R341 T2090 T2091 det these,factors
R342 T2091 T2088 nsubj factors,interact
R343 T2092 T2091 amod other,factors
R344 T2093 T2068 punct .,are
R345 T2095 T2096 det The,component
R346 T2096 T2098 nsubj component,is
R347 T2097 T2096 amod genetic,component
R348 T2099 T2098 acomp multigenic,is
R349 T2100 T2098 punct ", ",is
R350 T2101 T2098 prep with,is
R351 T2102 T2103 det the,heritability
R352 T2103 T2101 pobj heritability,with
R353 T2104 T2103 acl embedded,heritability
R354 T2105 T2104 prep in,embedded
R355 T2106 T2107 det the,variation
R356 T2107 T2105 pobj variation,in
R357 T2108 T2107 amod genetic,variation
R358 T2109 T2107 amod intrinsic,variation
R359 T2110 T2109 prep to,intrinsic
R360 T2111 T2112 poss our,population
R361 T2112 T2110 pobj population,to
R362 T2113 T2098 punct .,is
R363 T2115 T2116 mark Although,recognized
R364 T2116 T2124 advcl recognized,is
R365 T2117 T2118 det the,differences
R366 T2118 T2116 nsubjpass differences,recognized
R367 T2119 T2118 compound sex,differences
R368 T2120 T2118 prep in,differences
R369 T2121 T2122 compound disease,susceptibility
R370 T2122 T2120 pobj susceptibility,in
R371 T2123 T2116 auxpass are,recognized
R372 T2125 T2124 punct ", ",is
R373 T2126 T2127 det the,interplay
R374 T2127 T2124 nsubj interplay,is
R375 T2128 T2127 prep between,interplay
R376 T2129 T2128 pobj sex,between
R377 T2130 T2129 cc and,sex
R378 T2131 T2132 compound gene,expression
R379 T2132 T2129 conj expression,sex
R380 T2133 T2134 dep that,is
R381 T2134 T2127 relcl is,interplay
R382 T2135 T2134 prep at,is
R383 T2136 T2137 det the,basis
R384 T2137 T2135 pobj basis,at
R385 T2138 T2137 prep of,basis
R386 T2139 T2140 det these,differences
R387 T2140 T2138 pobj differences,of
R388 T2141 T2124 neg not,is
R389 T2142 T2143 advmod well,understood
R390 T2143 T2124 acomp understood,is
R391 T2144 T2124 punct .,is
R392 T2146 T2147 nsubj Females,inherit
R393 T2148 T2146 cc and,Females
R394 T2149 T2146 conj males,Females
R395 T2150 T2147 punct (,inherit
R396 T2151 T2147 prep on,inherit
R397 T2152 T2151 amod average,on
R398 T2153 T2147 punct ),inherit
R399 T2154 T2155 det the,genes
R400 T2155 T2147 dobj genes,inherit
R401 T2156 T2155 amod same,genes
R402 T2157 T2158 dep that,be
R403 T2158 T2155 relcl be,genes
R404 T2159 T2158 aux may,be
R405 T2160 T2161 compound risk,factors
R406 T2161 T2158 attr factors,be
R407 T2162 T2147 punct ", ",inherit
R408 T2163 T2147 cc but,inherit
R409 T2164 T2165 poss their,expression
R410 T2165 T2166 nsubj expression,varies
R411 T2166 T2147 conj varies,inherit
R412 T2167 T2165 cc and,expression
R413 T2168 T2165 conj effect,expression
R414 T2169 T2168 prep on,effect
R415 T2170 T2171 compound disease,risk
R416 T2171 T2169 pobj risk,on
R417 T2172 T2166 advmod significantly,varies
R418 T2173 T2166 punct .,varies
R419 T2175 T2176 det An,understanding
R420 T2176 T2177 nsubj understanding,is
R421 T2178 T2176 cc and,understanding
R422 T2179 T2176 conj recognition,understanding
R423 T2180 T2176 prep of,understanding
R424 T2181 T2182 det the,significance
R425 T2182 T2180 pobj significance,of
R426 T2183 T2182 prep of,significance
R427 T2184 T2185 amod specific,mutations
R428 T2185 T2183 pobj mutations,of
R429 T2186 T2187 npadvmod disease,associated
R430 T2187 T2185 amod associated,mutations
R431 T2188 T2187 punct -,associated
R432 T2189 T2185 compound polymorphisms,mutations
R433 T2190 T2185 punct /,mutations
R434 T2191 T2182 prep in,significance
R435 T2192 T2193 det the,context
R436 T2193 T2191 pobj context,in
R437 T2194 T2193 prep of,context
R438 T2195 T2194 pobj sex,of
R439 T2196 T2177 advmod therefore,is
R440 T2197 T2177 prep of,is
R441 T2198 T2199 amod critical,importance
R442 T2199 T2197 pobj importance,of
R443 T2200 T2199 amod clinical,importance
R444 T2201 T2177 punct .,is
R445 T2203 T2204 nsubj We,utilized
R446 T2205 T2204 aux have,utilized
R447 T2206 T2207 det the,mouse
R448 T2207 T2204 dobj mouse,utilized
R449 T2208 T2204 prep as,utilized
R450 T2209 T2210 det a,system
R451 T2210 T2208 pobj system,as
R452 T2211 T2210 compound model,system
R453 T2212 T2213 aux to,study
R454 T2213 T2204 advcl study,utilized
R455 T2214 T2215 det the,genetics
R456 T2215 T2213 dobj genetics,study
R457 T2216 T2215 prep of,genetics
R458 T2217 T2218 amod metabolic,diseases
R459 T2218 T2216 pobj diseases,of
R460 T2219 T2217 cc and,metabolic
R461 T2220 T2217 conj vascular,metabolic
R462 T2221 T2222 punct [,3
R463 T2222 T2204 parataxis 3,utilized
R464 T2223 T2224 punct –,5
R465 T2224 T2222 prep 5,3
R466 T2225 T2222 punct ],3
R467 T2226 T2204 punct .,utilized
R468 T2228 T2229 advmod Rather,utilize
R469 T2230 T2231 mark than,focus
R470 T2231 T2228 advcl focus,Rather
R471 T2232 T2231 advmod initially,focus
R472 T2233 T2231 prep on,focus
R473 T2234 T2235 amod natural,mutants
R474 T2235 T2233 pobj mutants,on
R475 T2236 T2234 cc or,natural
R476 T2237 T2234 conj induced,natural
R477 T2238 T2235 prep of,mutants
R478 T2239 T2240 amod single,genes
R479 T2240 T2238 pobj genes,of
R480 T2241 T2229 punct ", ",utilize
R481 T2242 T2229 nsubj we,utilize
R482 T2243 T2244 det the,variation
R483 T2244 T2229 dobj variation,utilize
R484 T2245 T2244 amod complex,variation
R485 T2246 T2244 amod endogenous,variation
R486 T2247 T2244 amod genetic,variation
R487 T2248 T2244 prep between,variation
R488 T2249 T2248 pobj strains,between
R489 T2250 T2249 prep in,strains
R490 T2251 T2252 amod genetic,crosses
R491 T2252 T2250 pobj crosses,in
R492 T2253 T2254 aux to,identify
R493 T2254 T2229 advcl identify,utilize
R494 T2255 T2256 amod causative,loci
R495 T2256 T2254 dobj loci,identify
R496 T2257 T2256 amod genetic,loci
R497 T2258 T2256 cc and,loci
R498 T2259 T2260 advmod ultimately,variations
R499 T2260 T2256 conj variations,loci
R500 T2261 T2260 det the,variations
R501 T2262 T2260 amod underlying,variations
R502 T2263 T2260 amod responsible,variations
R503 T2264 T2263 prep for,responsible
R504 T2265 T2266 compound trait,differences
R505 T2266 T2264 pobj differences,for
R506 T2267 T2268 punct [,6
R507 T2268 T2229 parataxis 6,utilize
R508 T2269 T2268 punct ],6
R509 T2270 T2229 punct .,utilize
R510 T2272 T2273 det This,design
R511 T2273 T2274 nsubj design,reflects
R512 T2275 T2276 advmod more,closely
R513 T2276 T2274 advmod closely,reflects
R514 T2277 T2278 det the,situation
R515 T2278 T2274 dobj situation,reflects
R516 T2279 T2278 acl faced,situation
R517 T2280 T2281 advmod when,studying
R518 T2281 T2279 advcl studying,faced
R519 T2282 T2283 amod human,populations
R520 T2283 T2281 dobj populations,studying
R521 T2284 T2274 punct .,reflects
R522 T2286 T2287 det The,composition
R523 T2287 T2289 nsubjpass composition,restricted
R524 T2288 T2287 amod genetic,composition
R525 T2290 T2287 prep of,composition
R526 T2291 T2292 det each,mouse
R527 T2292 T2290 pobj mouse,of
R528 T2293 T2292 amod individual,mouse
R529 T2294 T2289 auxpass is,restricted
R530 T2295 T2289 prep to,restricted
R531 T2296 T2295 pobj that,to
R532 T2297 T2296 prep of,that
R533 T2298 T2299 det the,strains
R534 T2299 T2297 pobj strains,of
R535 T2300 T2299 nummod two,strains
R536 T2301 T2299 amod parental,strains
R537 T2302 T2289 cc and,restricted
R538 T2303 T2304 auxpass is,defined
R539 T2304 T2289 conj defined,restricted
R540 T2305 T2304 prep at,defined
R541 T2306 T2307 det every,locus
R542 T2307 T2305 pobj locus,at
R543 T2308 T2307 prep across,locus
R544 T2309 T2310 det the,genome
R545 T2310 T2308 pobj genome,across
R546 T2311 T2289 punct .,restricted
R547 T2313 T2314 det The,application
R548 T2314 T2315 nsubj application,allows
R549 T2316 T2314 prep of,application
R550 T2317 T2318 amod quantitative,trait
R551 T2318 T2319 nmod trait,locus
R552 T2319 T2320 nmod locus,analysis
R553 T2320 T2316 pobj analysis,of
R554 T2321 T2319 punct (,locus
R555 T2322 T2319 appos QTL,locus
R556 T2323 T2320 punct ),analysis
R557 T2324 T2325 det the,identification
R558 T2325 T2315 dobj identification,allows
R559 T2326 T2325 prep of,identification
R560 T2327 T2328 det those,regions
R561 T2328 T2326 pobj regions,of
R562 T2329 T2328 amod chromosomal,regions
R563 T2330 T2331 dep that,contain
R564 T2331 T2328 relcl contain,regions
R565 T2332 T2333 det a,variation
R566 T2333 T2331 dobj variation,contain
R567 T2334 T2333 amod genetic,variation
R568 T2335 T2336 dep that,influences
R569 T2336 T2333 relcl influences,variation
R570 T2337 T2338 compound trait,expression
R571 T2338 T2336 dobj expression,influences
R572 T2339 T2340 punct (,see
R573 T2340 T2315 parataxis see,allows
R574 T2341 T2340 prep for,see
R575 T2342 T2343 det a,review
R576 T2343 T2341 pobj review,for
R577 T2344 T2343 amod comprehensive,review
R578 T2345 T2343 prep on,review
R579 T2346 T2345 pobj QTLs,on
R580 T2347 T2340 punct [,see
R581 T2348 T2340 dobj 7,see
R582 T2349 T2340 punct ],see
R583 T2350 T2340 punct ),see
R584 T2351 T2315 punct .,allows
R585 T2353 T2354 nsubj We,extended
R586 T2355 T2356 punct [,8
R587 T2356 T2353 parataxis 8,We
R588 T2357 T2356 nummod 5,8
R589 T2358 T2356 punct ",",8
R590 T2359 T2356 punct ],8
R591 T2360 T2353 punct ", ",We
R592 T2361 T2353 cc and,We
R593 T2362 T2353 conj others,We
R594 T2363 T2364 punct [,9
R595 T2364 T2362 parataxis 9,others
R596 T2365 T2366 punct –,17
R597 T2366 T2364 prep 17,9
R598 T2367 T2364 punct ],9
R599 T2368 T2354 punct ", ",extended
R600 T2369 T2354 aux have,extended
R601 T2370 T2354 advmod recently,extended
R602 T2371 T2372 det the,power
R603 T2372 T2354 dobj power,extended
R604 T2373 T2372 prep of,power
R605 T2374 T2375 det this,approach
R606 T2375 T2373 pobj approach,of
R607 T2376 T2354 prep by,extended
R608 T2377 T2376 pcomp incorporating,by
R609 T2378 T2379 npadvmod genome,wide
R610 T2379 T2381 amod wide,analysis
R611 T2380 T2379 punct -,wide
R612 T2381 T2377 dobj analysis,incorporating
R613 T2382 T2383 compound gene,expression
R614 T2383 T2381 compound expression,analysis
R615 T2384 T2381 compound array,analysis
R616 T2385 T2381 punct ", ",analysis
R617 T2386 T2387 dep which,allows
R618 T2387 T2381 relcl allows,analysis
R619 T2388 T2389 nsubj us,model
R620 T2389 T2387 ccomp model,allows
R621 T2390 T2389 aux to,model
R622 T2391 T2392 det the,genetics
R623 T2392 T2389 dobj genetics,model
R624 T2393 T2392 punct “,genetics
R625 T2394 T2392 prep of,genetics
R626 T2395 T2396 compound gene,expression
R627 T2396 T2394 pobj expression,of
R628 T2397 T2389 punct ”,model
R629 T2398 T2389 advcl using,model
R630 T2399 T2400 amod similar,methods
R631 T2400 T2398 dobj methods,using
R632 T2401 T2354 punct .,extended
R633 T2403 T2404 det An,extension
R634 T2404 T2406 nsubj extension,is
R635 T2405 T2404 amod immediate,extension
R636 T2407 T2404 prep of,extension
R637 T2408 T2409 det this,approach
R638 T2409 T2407 pobj approach,of
R639 T2410 T2406 prep toward,is
R640 T2411 T2410 pcomp dissecting,toward
R641 T2412 T2413 det the,regulation
R642 T2443 T2437 acl study,application
R643 T2413 T2411 dobj regulation,dissecting
R644 T2444 T2445 det the,significance
R645 T2414 T2413 amod genetic,regulation
R646 T2445 T2443 dobj significance,study
R647 T2446 T2445 prep of,significance
R648 T2415 T2413 prep of,regulation
R649 T2447 T2446 pobj sex,of
R650 T2448 T2445 prep on,significance
R651 T2416 T2417 amod complex,phenotypes
R652 T2449 T2450 det the,determinants
R653 T2450 T2448 pobj determinants,on
R654 T2451 T2450 amod genetic,determinants
R655 T2417 T2415 pobj phenotypes,of
R656 T2452 T2450 prep of,determinants
R657 T2453 T2452 pobj obesity,of
R658 T2454 T2450 cc and,determinants
R659 T2418 T2413 punct ", ",regulation
R660 T2455 T2456 det the,regulation
R661 T2456 T2450 conj regulation,determinants
R662 T2457 T2456 amod associated,regulation
R663 T2419 T2420 dep which,improve
R664 T2458 T2456 prep of,regulation
R665 T2459 T2460 compound liver,expression
R666 T2460 T2458 pobj expression,of
R667 T2461 T2460 compound gene,expression
R668 T2462 T2443 prep in,study
R669 T2420 T2413 relcl improve,regulation
R670 T2463 T2464 det an,intercross
R671 T2464 T2462 pobj intercross,in
R672 T2465 T2464 compound F2,intercross
R673 T2421 T2420 aux would,improve
R674 T2466 T2464 acl derived,intercross
R675 T2467 T2466 prep from,derived
R676 T2468 T2469 det the,strains
R677 T2422 T2420 advmod greatly,improve
R678 T2469 T2467 pobj strains,from
R679 T2470 T2469 amod inbred,strains
R680 T2471 T2472 compound C57BL,6J
R681 T2472 T2469 appos 6J,strains
R682 T2423 T2424 det the,progression
R683 T2424 T2420 dobj progression,improve
R684 T2473 T2472 punct /,6J
R685 T2474 T2475 punct (,B6
R686 T2425 T2424 prep from,progression
R687 T2475 T2472 parataxis B6,6J
R688 T2476 T2475 punct ),B6
R689 T2477 T2472 cc and,6J
R690 T2426 T2427 compound candidate,locus
R691 T2478 T2479 compound C3H,HeJ
R692 T2479 T2472 conj HeJ,6J
R693 T2480 T2479 punct /,HeJ
R694 T2427 T2425 pobj locus,from
R695 T2481 T2482 punct (,C3H
R696 T2482 T2479 parataxis C3H,HeJ
R697 T2483 T2482 punct ),C3H
R698 T2428 T2424 prep to,progression
R699 T2484 T2469 prep on,strains
R700 T2485 T2486 det an,background
R701 T2429 T2430 compound candidate,gene
R702 T2486 T2484 pobj background,on
R703 T2487 T2488 compound apolipoprotein,E
R704 T2488 T2489 npadvmod E,null
R705 T2430 T2428 pobj gene,to
R706 T2489 T2486 amod null,background
R707 T2490 T2491 punct (,ApoE
R708 T2491 T2486 parataxis ApoE,background
R709 T2431 T2406 punct .,is
R710 T2492 T2491 punct −,ApoE
R711 T2493 T2491 punct /,ApoE
R712 T2494 T2491 punct −,ApoE
R713 T2433 T2434 advmod Here,report
R714 T2495 T2491 punct ),ApoE
R715 T2496 T2434 punct .,report
R716 T2498 T2499 det The,population
R717 T2435 T2434 nsubj we,report
R718 T2499 T2504 nsubjpass population,designed
R719 T2500 T2499 nmod BXH.ApoE,population
R720 T2501 T2500 punct −,BXH.ApoE
R721 T2502 T2500 punct /,BXH.ApoE
R722 T2503 T2500 punct −,BXH.ApoE
R723 T2505 T2504 auxpass was,designed
R724 T2506 T2507 aux to,recapitulate
R725 T2436 T2437 det the,application
R726 T2507 T2504 advcl recapitulate,designed
R727 T2508 T2507 dobj several,recapitulate
R728 T2509 T2508 prep of,several
R729 T2437 T2434 dobj application,report
R730 T2510 T2511 det the,phenotypes
R731 T2511 T2509 pobj phenotypes,of
R732 T2512 T2511 acl associated,phenotypes
R733 T2438 T2437 prep of,application
R734 T2513 T2512 prep with,associated
R735 T2439 T2440 det this,approach
R736 T2514 T2515 det the,syndrome
R737 T2515 T2513 pobj syndrome,with
R738 T2516 T2517 advmod so,called
R739 T2517 T2515 amod called,syndrome
R740 T2440 T2438 pobj approach,of
R741 T2518 T2517 punct -,called
R742 T2519 T2515 amod metabolic,syndrome
R743 T2520 T2504 punct .,designed
R744 T2441 T2440 amod integrated,approach
R745 T2522 T2523 det The,cross
R746 T2523 T2524 nsubj cross,consists
R747 T2442 T2443 aux to,study
R748 T2525 T2524 prep of,consists
R749 T2549 T2550 nummod thousand,QTLs
R750 T2526 T2527 nummod 334,animals
R751 T2527 T2525 pobj animals,of
R752 T2528 T2527 prep of,animals
R753 T2529 T2530 det both,sexes
R754 T2530 T2528 pobj sexes,of
R755 T2531 T2524 punct ", ",consists
R756 T2550 T2547 dobj QTLs,detected
R757 T2532 T2524 advcl allowing,consists
R758 T2533 T2534 nsubj us,test
R759 T2534 T2532 ccomp test,allowing
R760 T2551 T2550 compound gene,QTLs
R761 T2535 T2534 aux to,test
R762 T2536 T2534 advmod specifically,test
R763 T2537 T2534 prep for,test
R764 T2552 T2550 compound expression,QTLs
R765 T2538 T2539 det the,dependence
R766 T2539 T2537 pobj dependence,for
R767 T2540 T2539 prep of,dependence
R768 T2553 T2550 punct (,QTLs
R769 T2541 T2540 pobj QTLs,of
R770 T2542 T2539 prep on,dependence
R771 T2543 T2542 pobj sex,on
R772 T2544 T2524 punct .,consists
R773 T2546 T2547 nsubj We,detected
R774 T2554 T2550 appos eQTLs,QTLs
R775 T2548 T2549 amod several,thousand
R776 T2555 T2550 punct ),QTLs
R777 T2556 T2550 punct ", ",QTLs
R778 T2557 T2558 det a,proportion
R779 T2558 T2560 dep proportion,were
R780 T2559 T2558 amod significant,proportion
R781 T2560 T2550 relcl were,QTLs
R782 T2561 T2558 prep of,proportion
R783 T2562 T2561 pobj which,of
R784 T2563 T2564 npadvmod sex,biased
R785 T2564 T2560 acomp biased,were
R786 T2565 T2564 punct -,biased
R787 T2566 T2547 punct .,detected
R788 T2568 T2569 nsubj We,used
R789 T2570 T2571 det these,analyses
R790 T2571 T2569 dobj analyses,used
R791 T2572 T2573 aux to,dissect
R792 T2573 T2569 advcl dissect,used
R793 T2574 T2575 det the,regulation
R794 T2575 T2573 dobj regulation,dissect
R795 T2576 T2575 amod genetic,regulation
R796 T2577 T2575 prep of,regulation
R797 T2578 T2579 det the,trait
R798 T2579 T2577 pobj trait,of
R799 T2580 T2581 amod gonadal,mass
R800 T2581 T2579 compound mass,trait
R801 T2582 T2581 compound fat,mass
R802 T2583 T2573 cc and,dissect
R803 T2584 T2585 aux to,identify
R804 T2585 T2573 conj identify,dissect
R805 T2586 T2585 dobj genes,identify
R806 T2587 T2586 acl associated,genes
R807 T2588 T2587 prep with,associated
R808 T2589 T2590 det the,trait
R809 T2590 T2588 pobj trait,with
R810 T2591 T2569 punct .,used
R811 T4642 T4641 acl Associated,QTLs
R812 T4643 T4642 prep with,Associated
R813 T4644 T4645 amod Gonadal,Mass
R814 T4645 T4643 pobj Mass,with
R815 T4646 T4645 compound Fat,Mass
R816 T4648 T4649 nsubjpass Characteristics,summarized
R817 T4650 T4648 prep of,Characteristics
R818 T4651 T4652 det the,parents
R819 T4652 T4650 pobj parents,of
R820 T4653 T4652 nmod B6.ApoE,parents
R821 T4654 T4653 punct −,B6.ApoE
R822 T4655 T4653 punct /,B6.ApoE
R823 T4656 T4653 punct −,B6.ApoE
R824 T4657 T4653 cc and,B6.ApoE
R825 T4658 T4653 conj C3H.ApoE,B6.ApoE
R826 T4659 T4658 punct −,C3H.ApoE
R827 T4660 T4658 punct /,C3H.ApoE
R828 T4661 T4658 punct −,C3H.ApoE
R829 T4662 T4652 cc and,parents
R830 T4663 T4664 det the,generation
R831 T4664 T4652 conj generation,parents
R832 T4665 T4664 nmod F2,generation
R833 T4666 T4664 nmod BXH.ApoE,generation
R834 T4667 T4666 punct −,BXH.ApoE
R835 T4668 T4666 punct /,BXH.ApoE
R836 T4669 T4666 punct −,BXH.ApoE
R837 T4670 T4652 prep on,parents
R838 T4671 T4672 det a,diet
R839 T4672 T4670 pobj diet,on
R840 T4673 T4672 compound Western,diet
R841 T4674 T4649 auxpass are,summarized
R842 T4675 T4649 prep in,summarized
R843 T4676 T4675 pobj Table,in
R844 T4677 T4676 nummod 1,Table
R845 T4678 T4649 punct .,summarized
R846 T4680 T4681 amod Gonadal,mass
R847 T4681 T4683 nsubj mass,differed
R848 T4682 T4681 compound fat,mass
R849 T4684 T4683 advmod significantly,differed
R850 T4685 T4683 prep between,differed
R851 T4686 T4687 det the,sexes
R852 T4687 T4685 pobj sexes,between
R853 T4688 T4683 prep in,differed
R854 T4689 T4688 pobj F2,in
R855 T4690 T4691 punct (,4
R856 T4691 T4689 parataxis 4,F2
R857 T4692 T4691 nsubj p,4
R858 T4693 T4691 punct <,4
R859 T4694 T4691 nummod 10,4
R860 T4695 T4691 punct −,4
R861 T4696 T4691 punct ),4
R862 T4697 T4688 cc and,in
R863 T4698 T4688 conj in,in
R864 T4699 T4700 det the,C3H.ApoE
R865 T4700 T4698 pobj C3H.ApoE,in
R866 T4701 T4700 amod parental,C3H.ApoE
R867 T4702 T4700 punct −,C3H.ApoE
R868 T4703 T4700 punct /,C3H.ApoE
R869 T4704 T4700 punct −,C3H.ApoE
R870 T4705 T4706 punct (,0.05
R871 T4706 T4700 parataxis 0.05,C3H.ApoE
R872 T4707 T4706 nsubj p,0.05
R873 T4708 T4706 punct <,0.05
R874 T4709 T4706 punct ),0.05
R875 T4710 T4688 punct ", ",in
R876 T4711 T4688 cc but,in
R877 T4712 T4711 neg not,but
R878 T4713 T4688 conj in,in
R879 T4714 T4715 nmod B6.ApoE,mice
R880 T4715 T4713 pobj mice,in
R881 T4716 T4714 punct −,B6.ApoE
R882 T4717 T4714 punct /,B6.ApoE
R883 T4718 T4714 punct −,B6.ApoE
R884 T4719 T4683 punct .,differed
R885 T4721 T4722 amod Gonadal,mass
R886 T4722 T4724 nsubj mass,was
R887 T4723 T4722 compound fat,mass
R888 T4725 T4726 det the,collection
R889 T4726 T4724 attr collection,was
R890 T4727 T4728 compound fat,pad
R891 T4728 T4726 compound pad,collection
R892 T4729 T4730 dep that,represented
R893 T4730 T4726 relcl represented,collection
R894 T4731 T4732 det the,animals
R895 T4732 T4730 dobj animals,represented
R896 T4733 T4732 amod most,animals
R897 T4734 T4732 cc and,animals
R898 T4735 T4736 det the,collections
R899 T4736 T4732 conj collections,animals
R900 T4737 T4738 advmod most,accurate
R901 T4738 T4736 amod accurate,collections
R902 T4739 T4730 cc and,represented
R903 T4740 T4741 auxpass was,chosen
R904 T4741 T4730 conj chosen,represented
R905 T4742 T4741 advmod thus,chosen
R906 T4743 T4741 prep for,chosen
R907 T4744 T4745 amod further,analysis
R908 T4745 T4743 pobj analysis,for
R909 T4746 T4724 punct .,was
R910 T4748 T4749 amod Broad,sense
R911 T4749 T4750 compound sense,heritability
R912 T4750 T4751 nsubj heritability,was
R913 T4752 T4753 punct (,h 2
R914 T4753 T4750 parataxis h 2,heritability
R915 T4754 T4753 punct ),h 2
R916 T4755 T4750 acl calculated,heritability
R917 T4756 T4755 prep as,calculated
R918 T4757 T4756 punct (,as
R919 T4758 T4759 nmod σ2 Total,σ2 Parental
R920 T4759 T4756 pobj σ2 Parental,as
R921 T4760 T4759 punct −,σ2 Parental
R922 T4761 T4759 punct ),σ2 Parental
R923 T4762 T4759 punct /,σ2 Parental
R924 T4763 T4759 appos σ2 Total,σ2 Parental
R925 T4764 T4755 prep for,calculated
R926 T4765 T4766 det the,trait
R927 T4766 T4764 pobj trait,for
R928 T4767 T4768 amod gonadal,mass
R929 T4768 T4766 compound mass,trait
R930 T4769 T4768 compound fat,mass
R931 T4770 T4771 nummod 54,%
R932 T4771 T4751 attr %,was
R933 T4772 T4771 prep for,%
R934 T4773 T4772 pobj females,for
R935 T4774 T4771 cc and,%
R936 T4775 T4776 nummod 36,%
R937 T4776 T4771 conj %,%
R938 T4777 T4776 prep for,%
R939 T4778 T4777 pobj males,for
R940 T4779 T4771 punct ", ",%
R941 T4780 T4781 dep which,is
R942 T4781 T4771 relcl is,%
R943 T4782 T4781 prep in,is
R944 T4783 T4784 amod close,agreement
R945 T4784 T4782 pobj agreement,in
R946 T4785 T4784 prep with,agreement
R947 T4786 T4787 amod previous,reports
R948 T4787 T4785 pobj reports,with
R949 T4788 T4789 punct [,19
R950 T4789 T4781 parataxis 19,is
R951 T4790 T4789 nummod 18,19
R952 T4791 T4789 punct ",",19
R953 T4792 T4789 punct ],19
R954 T4793 T4781 cc and,is
R955 T4794 T4781 conj demonstrates,is
R956 T4795 T4796 amod significant,heritability
R957 T4796 T4794 dobj heritability,demonstrates
R958 T4797 T4796 prep of,heritability
R959 T4798 T4799 amod gonadal,mass
R960 T4799 T4797 pobj mass,of
R961 T4800 T4799 compound fat,mass
R962 T4801 T4751 punct .,was
R963 T4803 T4804 det A,total
R964 T4804 T4805 nsubjpass total,genotyped
R965 T4806 T4804 prep of,total
R966 T4807 T4808 nummod 334,mice
R967 T4808 T4806 pobj mice,of
R968 T4809 T4808 compound F2,mice
R969 T4810 T4805 auxpass were,genotyped
R970 T4811 T4805 prep at,genotyped
R971 T4812 T4813 det an,density
R972 T4813 T4811 pobj density,at
R973 T4814 T4813 amod average,density
R974 T4815 T4816 nummod 1.5,cM
R975 T4816 T4813 compound cM,density
R976 T4817 T4805 advcl using,genotyped
R977 T4818 T4819 nummod "1,032",polymorphisms
R978 T4819 T4817 dobj polymorphisms,using
R979 T4820 T4821 amod single,nucleotide
R980 T4821 T4819 compound nucleotide,polymorphisms
R981 T4822 T4819 punct (,polymorphisms
R982 T4823 T4819 appos SNPs,polymorphisms
R983 T4824 T4819 punct ),polymorphisms
R984 T4825 T4819 acl spanning,polymorphisms
R985 T4826 T4827 det all,autosomes
R986 T4827 T4825 dobj autosomes,spanning
R987 T4828 T4827 nummod 19,autosomes
R988 T4829 T4805 punct .,genotyped
R989 T4831 T4832 compound QTL,analysis
R990 T4832 T4833 nsubjpass analysis,performed
R991 T4834 T4832 prep for,analysis
R992 T4835 T4836 amod several,traits
R993 T4836 T4834 pobj traits,for
R994 T4837 T4836 amod clinical,traits
R995 T4838 T4839 punct (,QTLs
R996 T4839 T4836 parataxis QTLs,traits
R997 T4840 T4839 amod clinical,QTLs
R998 T4841 T4839 punct [,QTLs
R999 T4842 T4839 appos cQTLs,QTLs
R1000 T4843 T4839 punct ],QTLs
R1001 T4844 T4839 punct ),QTLs
R1002 T4845 T4836 punct ", ",traits
R1003 T4846 T4836 prep including,traits
R1004 T4847 T4848 det the,values
R1005 T4848 T4846 pobj values,including
R1006 T4849 T4848 amod unadjusted,values
R1007 T4850 T4848 amod raw,values
R1008 T4851 T4848 prep for,values
R1009 T4852 T4853 amod gonadal,mass
R1010 T4853 T4851 pobj mass,for
R1011 T4854 T4853 compound fat,mass
R1012 T4855 T4833 punct ", ",performed
R1013 T4856 T4833 auxpass was,performed
R1014 T4857 T4833 advcl using,performed
R1015 T4858 T4859 det a,approach
R1016 T4859 T4857 dobj approach,using
R1017 T4860 T4861 amod single,marker
R1018 T4861 T4859 compound marker,approach
R1019 T4862 T4859 compound regression,approach
R1020 T4863 T4859 punct (,approach
R1021 T4864 T4859 acl justified,approach
R1022 T4865 T4864 agent by,justified
R1023 T4866 T4867 det the,density
R1024 T4867 T4865 pobj density,by
R1025 T4868 T4867 compound high,density
R1026 T4869 T4867 punct -,density
R1027 T4870 T4867 prep of,density
R1028 T4871 T4870 pobj markers,of
R1029 T4872 T4867 punct ", ",density
R1030 T4873 T4867 acl making,density
R1031 T4874 T4875 compound interval,mapping
R1032 T4875 T4876 nsubj mapping,unnecessary
R1033 T4876 T4873 ccomp unnecessary,making
R1034 T4877 T4833 punct ),performed
R1035 T4878 T4833 punct .,performed
R1036 T4880 T4881 prep In,included
R1037 T4882 T4880 pobj order,In
R1038 T4883 T4884 aux to,test
R1039 T4884 T4882 acl test,order
R1040 T4885 T4884 advmod specifically,test
R1041 T4886 T4884 prep for,test
R1042 T4887 T4888 compound sex,effects
R1043 T4888 T4886 pobj effects,for
R1044 T4889 T4888 prep of,effects
R1045 T4890 T4889 pobj linkage,of
R1046 T4891 T4881 punct ", ",included
R1047 T4892 T4881 nsubj we,included
R1048 T4893 T4894 amod additive,parameters
R1049 T4894 T4881 dobj parameters,included
R1050 T4895 T4893 punct ", ",additive
R1051 T4896 T4893 conj dominant,additive
R1052 T4897 T4896 punct ", ",dominant
R1053 T4898 T4896 conj sex,dominant
R1054 T4909 T4910 poss our,calculations
R1055 T4899 T4898 punct ", ",sex
R1056 T4910 T4908 pobj calculations,in
R1057 T4911 T4912 punct (,see
R1058 T4900 T4901 npadvmod sex,additive
R1059 T4901 T4898 conj additive,sex
R1060 T4912 T4881 parataxis see,included
R1061 T4902 T4901 punct -,additive
R1062 T4913 T4912 dobj Materials,see
R1063 T4914 T4913 cc and,Materials
R1064 T4903 T4901 punct ", ",additive
R1065 T4915 T4913 conj Methods,Materials
R1066 T4904 T4901 cc and,additive
R1067 T4916 T4912 punct ),see
R1068 T4905 T4906 npadvmod sex,dominant
R1069 T4906 T4901 conj dominant,additive
R1070 T4917 T4881 punct .,included
R1071 T4907 T4906 punct -,dominant
R1072 T4919 T4920 det A,procedure
R1073 T4908 T4881 prep in,included
R1074 T4920 T4923 nsubjpass procedure,used
R1075 T4921 T4920 amod stepwise,procedure
R1076 T4922 T4920 compound regression,procedure
R1077 T5015 T5014 dobj QTLs,detect
R1078 T4924 T4923 auxpass was,used
R1079 T4925 T4926 aux to,determine
R1080 T4926 T4923 advcl determine,used
R1081 T4927 T4928 mark whether,improved
R1082 T4928 T4926 ccomp improved,determine
R1083 T4929 T4930 det the,addition
R1084 T4930 T4928 nsubj addition,improved
R1085 T4931 T4930 prep of,addition
R1086 T5016 T5012 prep compared,power
R1087 T4932 T4933 det the,terms
R1088 T4933 T4931 pobj terms,of
R1089 T4934 T4933 amod final,terms
R1090 T5017 T5016 prep to,compared
R1091 T4935 T4933 nummod two,terms
R1092 T4936 T4928 advmod significantly,improved
R1093 T5018 T5019 compound QTL,methods
R1094 T4937 T4938 det the,model
R1095 T4938 T4928 dobj model,improved
R1096 T4939 T4940 amod linear,regression
R1097 T5019 T5017 pobj methods,to
R1098 T4940 T4938 compound regression,model
R1099 T5020 T5019 compound mapping,methods
R1100 T4941 T4928 punct ", ",improved
R1101 T4942 T4928 advcl conditional,improved
R1102 T4943 T4942 prep on,conditional
R1103 T4944 T4943 pcomp realizing,on
R1104 T5021 T5022 dep that,incorporate
R1105 T4945 T4946 det a,effect
R1106 T4946 T4944 dobj effect,realizing
R1107 T5022 T5019 relcl incorporate,methods
R1108 T4947 T4946 amod significant,effect
R1109 T4948 T4946 amod additive,effect
R1110 T4949 T4946 compound QTL,effect
R1111 T5023 T5022 aux do,incorporate
R1112 T4950 T4923 punct .,used
R1113 T4952 T4953 nsubj We,performed
R1114 T5024 T5022 neg not,incorporate
R1115 T4954 T4955 compound permutation,analyses
R1116 T5025 T5022 dobj sex,incorporate
R1117 T4955 T4953 dobj analyses,performed
R1118 T4956 T4953 prep over,performed
R1119 T5026 T5025 cc and,sex
R1120 T4957 T4958 det all,traits
R1121 T4958 T4956 pobj traits,over
R1122 T4959 T4960 compound gene,expression
R1123 T4960 T4958 compound expression,traits
R1124 T4961 T4953 punct ", ",performed
R1125 T5027 T5028 compound genotype,sex
R1126 T4962 T4953 advcl estimating,performed
R1127 T4963 T4964 amod false,rates
R1128 T4964 T4962 dobj rates,estimating
R1129 T5028 T5030 compound sex,interactions
R1130 T4965 T4964 compound discovery,rates
R1131 T4966 T4964 punct (,rates
R1132 T4967 T4964 appos FDRs,rates
R1133 T5029 T5028 punct –,sex
R1134 T4968 T4962 punct ),estimating
R1135 T4969 T4962 prep at,estimating
R1136 T4970 T4971 amod different,thresholds
R1137 T5030 T5025 conj interactions,sex
R1138 T4971 T4969 pobj thresholds,at
R1139 T4972 T4971 nmod logarithm,thresholds
R1140 T4973 T4972 prep of,logarithm
R1141 T5031 T5032 punct (,S1
R1142 T4974 T4973 pobj odds,of
R1143 T4975 T4972 punct (,logarithm
R1144 T4976 T4972 appos LOD,logarithm
R1145 T5032 T5006 parataxis S1,has
R1146 T4977 T4971 punct ),thresholds
R1147 T4978 T4971 compound score,thresholds
R1148 T4979 T4962 cc and,estimating
R1149 T5033 T5032 compound Figure,S1
R1150 T4980 T4962 conj assessing,estimating
R1151 T4981 T4982 det the,rate
R1152 T5034 T5032 punct ),S1
R1153 T4982 T4980 dobj rate,assessing
R1154 T4983 T4982 amod overall,rate
R1155 T4984 T4982 prep of,rate
R1156 T5035 T4990 punct .,constructed
R1157 T4985 T4986 compound QTL,detection
R1158 T4986 T4984 pobj detection,of
R1159 T4987 T4953 punct .,performed
R1160 T5037 T5038 nsubj It,is
R1161 T4989 T4990 prep From,constructed
R1162 T4991 T4992 det these,analyses
R1163 T5039 T5038 acomp clear,is
R1164 T4992 T4989 pobj analyses,From
R1165 T4993 T4990 nsubj we,constructed
R1166 T4994 T4995 compound receiver,operating
R1167 T4995 T4996 npadvmod operating,like
R1168 T5040 T5038 prep from,is
R1169 T5041 T5042 det the,curves
R1170 T4996 T5002 amod like,curves
R1171 T4997 T4995 amod characteristic,operating
R1172 T5042 T5040 pobj curves,from
R1173 T4998 T4995 punct (,operating
R1174 T4999 T4995 appos ROC,operating
R1175 T5000 T4996 punct ),like
R1176 T5001 T4996 punct -,like
R1177 T5002 T4990 dobj curves,constructed
R1178 T5003 T5004 aux to,demonstrate
R1179 T5043 T5042 compound ROC,curves
R1180 T5004 T4990 advcl demonstrate,constructed
R1181 T5005 T5006 mark that,has
R1182 T5044 T5045 mark that,add
R1183 T5006 T5004 ccomp has,demonstrate
R1184 T5007 T5008 poss our,method
R1185 T5045 T5038 ccomp add,is
R1186 T5008 T5006 nsubj method,has
R1187 T5009 T5008 amod straightforward,method
R1188 T5010 T5011 advmod significantly,increased
R1189 T5046 T5047 det the,terms
R1190 T5011 T5012 amod increased,power
R1191 T5012 T5006 dobj power,has
R1192 T5047 T5045 nsubj terms,add
R1193 T5013 T5014 aux to,detect
R1194 T5014 T5012 acl detect,power
R1195 T5048 T5047 nmod sex,terms
R1196 T5049 T5048 cc and,sex
R1197 T5050 T5051 compound sex,interaction
R1198 T5051 T5048 conj interaction,sex
R1199 T5052 T5051 punct -,interaction
R1200 T5053 T5045 advmod significantly,add
R1201 T5121 T5113 punct ", ",0.05
R1202 T5054 T5045 prep to,add
R1203 T5122 T5123 npadvmod genome,wide
R1204 T5123 T5125 amod wide,p
R1205 T5055 T5056 det the,detection
R1206 T5124 T5123 punct -,wide
R1207 T5125 T5113 nsubj p,0.05
R1208 T5056 T5054 pobj detection,to
R1209 T5126 T5113 punct <,0.05
R1210 T5127 T5113 punct ),0.05
R1211 T5128 T5067 punct .,have
R1212 T5057 T5056 prep of,detection
R1213 T5130 T5131 compound QTL,models
R1214 T5058 T5057 pobj QTL,of
R1215 T5131 T5132 nsubj models,have
R1216 T5059 T5056 prep for,detection
R1217 T5133 T5131 acl incorporating,models
R1218 T5134 T5133 advmod only,incorporating
R1219 T5060 T5061 det the,traits
R1220 T5135 T5136 det the,term
R1221 T5136 T5133 dobj term,incorporating
R1222 T5137 T5138 nmod sex,add
R1223 T5061 T5059 pobj traits,for
R1224 T5138 T5136 compound add,term
R1225 T5139 T5138 punct *,add
R1226 T5140 T5136 compound interaction,term
R1227 T5141 T5136 prep in,term
R1228 T5142 T5141 pobj addition,in
R1229 T5143 T5142 prep to,addition
R1230 T5062 T5063 compound gene,expression
R1231 T5144 T5145 det the,terms
R1232 T5145 T5143 pobj terms,to
R1233 T5146 T5145 amod additive,terms
R1234 T5063 T5061 compound expression,traits
R1235 T5147 T5148 nummod one,degree
R1236 T5148 T5132 dobj degree,have
R1237 T5149 T5148 amod extra,degree
R1238 T5064 T5038 punct .,is
R1239 T5150 T5148 prep of,degree
R1240 T5151 T5150 pobj freedom,of
R1241 T5152 T5153 dep that,leads
R1242 T5066 T5067 advcl Using,have
R1243 T5153 T5148 relcl leads,degree
R1244 T5154 T5153 prep to,leads
R1245 T5155 T5156 det a,increase
R1246 T5156 T5154 pobj increase,to
R1247 T5068 T5069 advmod previously,described
R1248 T5157 T5156 amod corresponding,increase
R1249 T5158 T5156 prep in,increase
R1250 T5159 T5160 det the,thresholds
R1251 T5160 T5158 pobj thresholds,in
R1252 T5069 T5070 amod described,conventions
R1253 T5161 T5160 compound LOD,thresholds
R1254 T5162 T5160 compound score,thresholds
R1255 T5163 T5156 prep to,increase
R1256 T5070 T5066 dobj conventions,Using
R1257 T5164 T5163 pobj 3.5,to
R1258 T5071 T5072 punct [,20
R1259 T5072 T5066 parataxis 20,Using
R1260 T5165 T5166 punct (,suggestive
R1261 T5166 T5164 parataxis suggestive,3.5
R1262 T5073 T5072 punct ],20
R1263 T5167 T5166 punct ),suggestive
R1264 T5168 T5164 cc and,3.5
R1265 T5169 T5164 conj 4.9,3.5
R1266 T5074 T5067 punct ", ",have
R1267 T5170 T5171 punct (,significant
R1268 T5075 T5076 compound QTL,models
R1269 T5171 T5169 parataxis significant,4.9
R1270 T5172 T5171 punct ),significant
R1271 T5076 T5067 nsubj models,have
R1272 T5173 T5164 prep for,3.5
R1273 T5174 T5175 det the,thresholds
R1274 T5077 T5076 prep without,models
R1275 T5175 T5173 pobj thresholds,for
R1276 T5176 T5175 nummod 0.001,thresholds
R1277 T5177 T5176 cc and,0.001
R1278 T5178 T5176 conj 0.00005,0.001
R1279 T5179 T5180 compound p,value
R1280 T5180 T5175 compound value,thresholds
R1281 T5181 T5180 punct -,value
R1282 T5078 T5079 det the,terms
R1283 T5182 T5153 punct ", ",leads
R1284 T5183 T5153 advmod respectively,leads
R1285 T5184 T5132 punct .,have
R1286 T5079 T5077 pobj terms,without
R1287 T5186 T5187 compound QTL,models
R1288 T5187 T5188 nsubj models,possess
R1289 T5080 T5079 amod final,terms
R1290 T5189 T5187 acl incorporating,models
R1291 T5190 T5191 preconj both,add
R1292 T5081 T5079 nummod two,terms
R1293 T5191 T5194 nmod add,terms
R1294 T5192 T5191 nmod sex,add
R1295 T5193 T5191 punct *,add
R1296 T5082 T5079 compound interaction,terms
R1297 T5194 T5189 dobj terms,incorporating
R1298 T5195 T5191 cc and,add
R1299 T5196 T5197 nmod sex,dom
R1300 T5083 T5079 punct (,terms
R1301 T5197 T5191 conj dom,add
R1302 T5198 T5197 punct *,dom
R1303 T5199 T5194 compound interaction,terms
R1304 T5200 T5201 nummod two,degrees
R1305 T5201 T5188 dobj degrees,possess
R1306 T5202 T5201 amod extra,degrees
R1307 T5084 T5085 nmod sex,add
R1308 T5203 T5201 prep of,degrees
R1309 T5204 T5203 pobj freedom,of
R1310 T5205 T5188 punct ", ",possess
R1311 T5085 T5079 appos add,terms
R1312 T5206 T5188 prep with,possess
R1313 T5207 T5208 det a,increase
R1314 T5086 T5085 punct *,add
R1315 T5208 T5206 pobj increase,with
R1316 T5209 T5208 amod corresponding,increase
R1317 T5210 T5208 prep in,increase
R1318 T5087 T5085 cc and,add
R1319 T5211 T5212 compound LOD,thresholds
R1320 T5088 T5089 nmod sex,dom
R1321 T5212 T5210 pobj thresholds,in
R1322 T5213 T5212 compound score,thresholds
R1323 T5214 T5208 prep to,increase
R1324 T5215 T5214 pobj 4.0,to
R1325 T5089 T5085 conj dom,add
R1326 T5216 T5217 punct (,suggestive
R1327 T5217 T5215 parataxis suggestive,4.0
R1328 T5218 T5217 punct ),suggestive
R1329 T5219 T5215 cc and,4.0
R1330 T5220 T5215 conj 5.4,4.0
R1331 T5221 T5222 punct (,significant
R1332 T5222 T5220 parataxis significant,5.4
R1333 T5090 T5089 punct *,dom
R1334 T5223 T5222 punct ),significant
R1335 T5224 T5215 prep for,4.0
R1336 T5225 T5226 det the,thresholds
R1337 T5091 T5067 punct ),have
R1338 T5226 T5224 pobj thresholds,for
R1339 T5092 T5093 det a,threshold
R1340 T5093 T5067 dobj threshold,have
R1341 T5094 T5093 amod suggestive,threshold
R1342 T5095 T5093 prep of,threshold
R1343 T5227 T5226 nummod 0.001,thresholds
R1344 T5228 T5227 cc and,0.001
R1345 T5096 T5095 pobj 3.0,of
R1346 T5229 T5227 conj 0.00005,0.001
R1347 T5230 T5231 compound p,value
R1348 T5231 T5226 compound value,thresholds
R1349 T5097 T5098 punct (,1
R1350 T5232 T5231 punct -,value
R1351 T5233 T5208 punct ", ",increase
R1352 T5234 T5208 advmod respectively,increase
R1353 T5098 T5096 parataxis 1,3.0
R1354 T5235 T5188 punct .,possess
R1355 T5237 T5238 advmod One,suggestive
R1356 T5099 T5098 nsubj p,1
R1357 T5238 T5239 amod suggestive,cQTLs
R1358 T5100 T5098 punct <,1
R1359 T5101 T5098 punct ×,1
R1360 T5239 T5258 nsubjpass cQTLs,identified
R1361 T5240 T5241 punct (,Chromosome
R1362 T5102 T5103 nummod 10,3
R1363 T5241 T5238 parataxis Chromosome,suggestive
R1364 T5242 T5241 nummod 1,Chromosome
R1365 T5243 T5241 punct ),Chromosome
R1366 T5103 T5098 appos 3,1
R1367 T5244 T5238 cc and,suggestive
R1368 T5245 T5246 advmod four,significant
R1369 T5104 T5103 punct −,3
R1370 T5246 T5238 conj significant,suggestive
R1371 T5247 T5248 punct (,3
R1372 T5248 T5246 parataxis 3,significant
R1373 T5105 T5098 punct ),1
R1374 T5249 T5248 nmod Chromosomes,3
R1375 T5250 T5248 punct ", ",3
R1376 T5251 T5248 conj 5,3
R1377 T5106 T5093 cc and,threshold
R1378 T5252 T5251 punct ", ",5
R1379 T5253 T5251 conj 11,5
R1380 T5107 T5108 det a,threshold
R1381 T5254 T5253 punct ", ",11
R1382 T5255 T5253 cc and,11
R1383 T5256 T5253 conj 19,11
R1384 T5257 T5248 punct ),3
R1385 T5259 T5239 prep for,cQTLs
R1386 T5108 T5093 conj threshold,threshold
R1387 T5260 T5261 det the,trait
R1388 T5261 T5259 pobj trait,for
R1389 T5262 T5263 amod gonadal,mass
R1390 T5109 T5108 amod significant,threshold
R1391 T5263 T5261 compound mass,trait
R1392 T5264 T5263 compound fat,mass
R1393 T5265 T5258 auxpass were,identified
R1394 T5110 T5108 prep of,threshold
R1395 T5266 T5267 punct (,Table
R1396 T5267 T5258 parataxis Table,identified
R1397 T5111 T5110 pobj 4.3,of
R1398 T5268 T5269 compound Figure,1A
R1399 T5269 T5267 dep 1A,Table
R1400 T5112 T5113 punct (,0.05
R1401 T5270 T5267 punct ;,Table
R1402 T5271 T5267 nummod 2,Table
R1403 T5272 T5267 punct ),Table
R1404 T5273 T5258 punct .,identified
R1405 T5113 T5111 parataxis 0.05,4.3
R1406 T5275 T5276 quantmod Four,five
R1407 T5276 T5280 nummod five,cQTLs
R1408 T5114 T5115 nsubj p,5
R1409 T5277 T5276 quantmod out,five
R1410 T5278 T5276 quantmod of,five
R1411 T5279 T5276 quantmod the,five
R1412 T5115 T5113 ccomp 5,0.05
R1413 T5280 T5281 nsubj cQTLs,showed
R1414 T5282 T5283 advmod statistically,significant
R1415 T5116 T5115 punct <,5
R1416 T5283 T5284 amod significant,fits
R1417 T5284 T5281 dobj fits,showed
R1418 T5285 T5284 amod better,fits
R1419 T5117 T5115 punct ×,5
R1420 T5286 T5281 prep with,showed
R1421 T5287 T5288 det the,model
R1422 T5288 T5286 pobj model,with
R1423 T5118 T5119 nummod 10,5
R1424 T5289 T5288 amod full,model
R1425 T5290 T5288 acl incorporating,model
R1426 T5291 T5292 det the,terms
R1427 T5119 T5115 appos 5,5
R1428 T5292 T5290 dobj terms,incorporating
R1429 T5293 T5292 compound interaction,terms
R1430 T5294 T5292 appos sex,terms
R1431 T5120 T5119 punct −,5
R1432 T5295 T5296 punct *,add
R1433 T5296 T5294 prep add,sex
R1434 T5297 T5294 cc and,sex
R1435 T5298 T5294 conj sex,sex
R1436 T5299 T5300 punct *,dom
R1437 T5333 T5334 amod improved,detection
R1438 T5300 T5298 prep dom,sex
R1439 T5301 T5288 punct ", ",model
R1440 T5302 T5288 prep compared,model
R1441 T5303 T5302 prep to,compared
R1442 T5304 T5305 det the,model
R1443 T5334 T5332 pobj detection,to
R1444 T5305 T5303 pobj model,to
R1445 T5306 T5305 prep including,model
R1446 T5307 T5308 advmod only,terms
R1447 T5308 T5306 pobj terms,including
R1448 T5309 T5308 det the,terms
R1449 T5310 T5308 amod additive,terms
R1450 T5335 T5334 prep of,detection
R1451 T5311 T5281 punct .,showed
R1452 T5313 T5314 advmod Interestingly,improve
R1453 T5336 T5337 det this,locus
R1454 T5337 T5335 pobj locus,of
R1455 T5315 T5314 punct ", ",improve
R1456 T5316 T5317 det the,cQTL
R1457 T5338 T5314 punct .,improve
R1458 T5317 T5314 nsubj cQTL,improve
R1459 T5318 T5317 prep over,cQTL
R1460 T5319 T5318 pobj Chromosome,over
R1461 T5340 T5341 nsubj Table,summarizes
R1462 T5320 T5319 nummod 11,Chromosome
R1463 T5321 T5314 aux did,improve
R1464 T5322 T5314 neg not,improve
R1465 T5323 T5314 punct ", ",improve
R1466 T5342 T5340 nummod 2,Table
R1467 T5324 T5314 advcl suggesting,improve
R1468 T5325 T5326 mark that,contribute
R1469 T5326 T5324 ccomp contribute,suggesting
R1470 T5327 T5328 det the,terms
R1471 T5328 T5326 nsubj terms,contribute
R1472 T5343 T5344 det the,position
R1473 T5329 T5328 amod additional,terms
R1474 T5330 T5326 aux did,contribute
R1475 T5331 T5326 neg not,contribute
R1476 T5344 T5341 dobj position,summarizes
R1477 T5332 T5326 prep to,contribute
R1478 T5345 T5344 cc and,position
R1479 T5346 T5347 compound LOD,score
R1480 T5347 T5344 conj score,position
R1481 T5439 T5438 prep of,evidence
R1482 T5348 T5344 prep of,position
R1483 T5440 T5439 pobj linkage,of
R1484 T5441 T5438 prep on,evidence
R1485 T5442 T5441 pobj Chromosome,on
R1486 T5443 T5442 nummod 5,Chromosome
R1487 T5349 T5350 amod maximal,linkage
R1488 T5444 T5425 punct .,failed
R1489 T5446 T5447 advmod When,analyzed
R1490 T5350 T5348 pobj linkage,of
R1491 T5447 T5450 advcl analyzed,realized
R1492 T5448 T5447 nsubjpass females,analyzed
R1493 T5449 T5447 auxpass were,analyzed
R1494 T5351 T5341 prep for,summarizes
R1495 T5450 T5460 ccomp realized,demonstrate
R1496 T5451 T5447 advmod alone,analyzed
R1497 T5452 T5450 punct ", ",realized
R1498 T5352 T5353 det each,cQTL
R1499 T5453 T5454 det a,score
R1500 T5454 T5450 nsubjpass score,realized
R1501 T5455 T5454 amod suggestive,score
R1502 T5353 T5351 pobj cQTL,for
R1503 T5456 T5454 compound LOD,score
R1504 T5457 T5454 prep of,score
R1505 T5458 T5457 pobj 3.7,of
R1506 T5459 T5450 auxpass was,realized
R1507 T5354 T5341 punct .,summarizes
R1508 T5461 T5462 punct (,2
R1509 T5462 T5450 parataxis 2,realized
R1510 T5356 T5357 mark While,was
R1511 T5463 T5462 nsubj p,2
R1512 T5464 T5462 punct =,2
R1513 T5465 T5462 punct ×,2
R1514 T5357 T5363 advcl was,noted
R1515 T5466 T5467 nummod 10,4
R1516 T5467 T5462 appos 4,2
R1517 T5358 T5359 det the,focus
R1518 T5468 T5467 punct −,4
R1519 T5469 T5462 punct ),2
R1520 T5470 T5460 punct ;,demonstrate
R1521 T5359 T5357 nsubj focus,was
R1522 T5471 T5460 nsubj males,demonstrate
R1523 T5472 T5471 acl analyzed,males
R1524 T5473 T5472 advmod alone,analyzed
R1525 T5360 T5359 prep of,focus
R1526 T5474 T5460 aux did,demonstrate
R1527 T5475 T5460 neg not,demonstrate
R1528 T5476 T5460 dobj evidence,demonstrate
R1529 T5361 T5362 det this,study
R1530 T5477 T5476 prep for,evidence
R1531 T5478 T5477 pobj linkage,for
R1532 T5362 T5360 pobj study,of
R1533 T5479 T5460 punct .,demonstrate
R1534 T5481 T5482 advmod However,improved
R1535 T5364 T5365 det the,trait
R1536 T5483 T5482 punct ", ",improved
R1537 T5484 T5482 csubj using,improved
R1538 T5485 T5486 det all,animals
R1539 T5486 T5484 dobj animals,using
R1540 T5487 T5486 nummod 334,animals
R1541 T5365 T5357 attr trait,was
R1542 T5488 T5484 cc and,using
R1543 T5489 T5484 conj adding,using
R1544 T5366 T5367 amod gonadal,mass
R1545 T5490 T5491 det the,terms
R1546 T5491 T5489 dobj terms,adding
R1547 T5492 T5491 compound interaction,terms
R1548 T5367 T5365 compound mass,trait
R1549 T5493 T5489 prep to,adding
R1550 T5494 T5495 det the,model
R1551 T5495 T5493 pobj model,to
R1552 T5368 T5367 compound fat,mass
R1553 T5496 T5495 compound QTL,model
R1554 T5497 T5482 advmod significantly,improved
R1555 T5498 T5482 dobj sensitivity,improved
R1556 T5369 T5363 punct ", ",noted
R1557 T5499 T5482 punct ", ",improved
R1558 T5500 T5482 cc and,improved
R1559 T5370 T5363 nsubjpass it,noted
R1560 T5501 T5502 det a,cQTL
R1561 T5502 T5503 nsubjpass cQTL,realized
R1562 T5371 T5363 auxpass is,noted
R1563 T5372 T5373 mark that,resulted
R1564 T5503 T5482 conj realized,improved
R1565 T5373 T5363 ccomp resulted,noted
R1566 T5504 T5502 prep with,cQTL
R1567 T5505 T5506 det a,LOD
R1568 T5374 T5375 det a,scan
R1569 T5506 T5504 pobj LOD,with
R1570 T5507 T5506 compound maximum,LOD
R1571 T5508 T5506 prep of,LOD
R1572 T5375 T5373 nsubj scan,resulted
R1573 T5509 T5508 pobj 7.56,of
R1574 T5510 T5511 punct (,1.7
R1575 T5511 T5502 parataxis 1.7,cQTL
R1576 T5376 T5375 compound genome,scan
R1577 T5512 T5511 nsubj p,1.7
R1578 T5513 T5511 punct =,1.7
R1579 T5514 T5511 punct ×,1.7
R1580 T5377 T5375 prep for,scan
R1581 T5515 T5516 nummod 10,6
R1582 T5516 T5511 appos 6,1.7
R1583 T5517 T5516 punct −,6
R1584 T5378 T5379 det the,trait
R1585 T5518 T5511 punct ),1.7
R1586 T5519 T5503 auxpass was,realized
R1587 T5520 T5482 punct .,improved
R1588 T5522 T5523 prep Given,hypothesized
R1589 T5379 T5377 pobj trait,for
R1590 T5524 T5525 det the,detection
R1591 T5525 T5522 pobj detection,Given
R1592 T5380 T5379 compound adiposity,trait
R1593 T5526 T5525 amod improved,detection
R1594 T5527 T5525 prep of,detection
R1595 T5528 T5529 quantmod four,five
R1596 T5381 T5373 prep in,resulted
R1597 T5529 T5532 nummod five,cQTLs
R1598 T5530 T5529 quantmod of,five
R1599 T5531 T5529 quantmod the,five
R1600 T5382 T5381 pobj cQTLs,in
R1601 T5532 T5527 pobj cQTLs,of
R1602 T5533 T5534 advmod when,considered
R1603 T5534 T5525 relcl considered,detection
R1604 T5383 T5382 prep at,cQTLs
R1605 T5535 T5536 npadvmod sex,additive
R1606 T5536 T5538 amod additive,terms
R1607 T5537 T5536 punct -,additive
R1608 T5384 T5385 det the,locations
R1609 T5538 T5534 nsubjpass terms,considered
R1610 T5539 T5536 cc and,additive
R1611 T5540 T5541 npadvmod sex,dominant
R1612 T5385 T5383 pobj locations,at
R1613 T5541 T5536 conj dominant,additive
R1614 T5542 T5541 punct -,dominant
R1615 T5543 T5538 compound interaction,terms
R1616 T5386 T5385 amod same,locations
R1617 T5544 T5534 auxpass were,considered
R1618 T5387 T5382 punct ", ",cQTLs
R1619 T5388 T5382 prep with,cQTLs
R1620 T5545 T5523 punct ", ",hypothesized
R1621 T5389 T5390 advmod very,similar
R1622 T5546 T5523 nsubj we,hypothesized
R1623 T5547 T5548 mark that,differ
R1624 T5390 T5391 amod similar,scores
R1625 T5548 T5523 ccomp differ,hypothesized
R1626 T5549 T5550 det the,effect
R1627 T5550 T5548 nsubj effect,differ
R1628 T5391 T5388 pobj scores,with
R1629 T5551 T5550 amod main,effect
R1630 T5552 T5550 compound genotype,effect
R1631 T5553 T5550 prep of,effect
R1632 T5392 T5391 compound LOD,scores
R1633 T5554 T5555 det these,cQTLs
R1634 T5555 T5553 pobj cQTLs,of
R1635 T5556 T5550 prep on,effect
R1636 T5393 T5391 cc and,scores
R1637 T5557 T5558 det the,trait
R1638 T5558 T5556 pobj trait,on
R1639 T5559 T5560 amod gonadal,mass
R1640 T5560 T5558 compound mass,trait
R1641 T5561 T5560 compound fat,mass
R1642 T5562 T5548 aux would,differ
R1643 T5394 T5395 compound sex,dependence
R1644 T5563 T5548 prep between,differ
R1645 T5564 T5565 det the,sexes
R1646 T5395 T5391 conj dependence,scores
R1647 T5565 T5563 pobj sexes,between
R1648 T5396 T5397 punct (,data
R1649 T5566 T5567 punct (,Figure
R1650 T5567 T5523 parataxis Figure,hypothesized
R1651 T5568 T5567 nummod 2,Figure
R1652 T5569 T5567 punct ),Figure
R1653 T5397 T5363 parataxis data,noted
R1654 T5570 T5523 punct .,hypothesized
R1655 T5398 T5397 amod unpublished,data
R1656 T5572 T5573 advmod Indeed,showed
R1657 T5574 T5573 punct ", ",showed
R1658 T5399 T5397 punct ),data
R1659 T5575 T5573 nsubj cQTLs,showed
R1660 T5576 T5575 acl located,cQTLs
R1661 T5577 T5576 prep on,located
R1662 T5400 T5363 punct .,noted
R1663 T5578 T5579 nmod Chromosomes,1
R1664 T5579 T5577 pobj 1,on
R1665 T5580 T5579 punct ", ",1
R1666 T5402 T5403 nsubjpass Results,depicted
R1667 T5581 T5579 conj 3,1
R1668 T5582 T5581 punct ", ",3
R1669 T5583 T5581 cc and,3
R1670 T5584 T5581 conj 5,3
R1671 T5585 T5586 amod opposing,effects
R1672 T5404 T5402 prep from,Results
R1673 T5586 T5573 dobj effects,showed
R1674 T5587 T5586 prep on,effects
R1675 T5588 T5589 compound fat,mass
R1676 T5589 T5587 pobj mass,on
R1677 T5405 T5406 det the,models
R1678 T5406 T5404 pobj models,from
R1679 T5590 T5589 punct ", ",mass
R1680 T5591 T5589 cc or,mass
R1681 T5407 T5406 amod various,models
R1682 T5592 T5593 compound sex,antagonism
R1683 T5593 T5589 conj antagonism,mass
R1684 T5594 T5573 punct .,showed
R1685 T5408 T5406 compound regression,models
R1686 T5596 T5597 det The,effect
R1687 T5597 T5598 nsubj effect,was
R1688 T5409 T5406 acl used,models
R1689 T5599 T5597 prep of,effect
R1690 T5600 T5601 det the,cQTL
R1691 T5410 T5411 aux to,determine
R1692 T5601 T5599 pobj cQTL,of
R1693 T5602 T5597 prep on,effect
R1694 T5603 T5602 pobj Chromosome,on
R1695 T5604 T5603 nummod 11,Chromosome
R1696 T5605 T5598 prep in,was
R1697 T5411 T5409 advcl determine,used
R1698 T5606 T5607 det the,direction
R1699 T5607 T5605 pobj direction,in
R1700 T5608 T5607 amod same,direction
R1701 T5412 T5411 dobj linkage,determine
R1702 T5609 T5598 prep in,was
R1703 T5610 T5611 preconj both,males
R1704 T5413 T5411 prep for,determine
R1705 T5611 T5609 pobj males,in
R1706 T5612 T5611 cc and,males
R1707 T5613 T5611 conj females,males
R1708 T5414 T5415 det the,cQTL
R1709 T5614 T5598 punct ", ",was
R1710 T5615 T5598 cc but,was
R1711 T5616 T5617 auxpass was,biased
R1712 T5415 T5413 pobj cQTL,for
R1713 T5617 T5598 conj biased,was
R1714 T5618 T5617 dep sex,biased
R1715 T5619 T5617 punct -,biased
R1716 T5416 T5415 nmod Chromosome,cQTL
R1717 T5620 T5617 prep toward,biased
R1718 T5621 T5622 det a,effect
R1719 T5622 T5620 pobj effect,toward
R1720 T5417 T5416 nummod 5,Chromosome
R1721 T5623 T5622 amod larger,effect
R1722 T5624 T5622 prep in,effect
R1723 T5625 T5624 pobj females,in
R1724 T5418 T5403 auxpass are,depicted
R1725 T5626 T5627 punct (,0.091
R1726 T5627 T5617 parataxis 0.091,biased
R1727 T5628 T5627 nsubj R 2,0.091
R1728 T5419 T5403 prep in,depicted
R1729 T5629 T5627 punct =,0.091
R1730 T5630 T5627 prep in,0.091
R1731 T5631 T5630 pobj females,in
R1732 T5420 T5421 compound Figure,1B
R1733 T5632 T5627 cc versus,0.091
R1734 T5633 T5634 nsubj R 2,0.046
R1735 T5634 T5627 conj 0.046,0.091
R1736 T5635 T5634 punct =,0.046
R1737 T5636 T5634 prep in,0.046
R1738 T5421 T5419 pobj 1B,in
R1739 T5637 T5636 pobj males,in
R1740 T5638 T5627 punct ),0.091
R1741 T5639 T5598 punct ", ",was
R1742 T5422 T5403 punct .,depicted
R1743 T5640 T5598 advcl confirming,was
R1744 T5641 T5642 det the,specificity
R1745 T5642 T5640 dobj specificity,confirming
R1746 T5643 T5642 amod minimal,specificity
R1747 T5644 T5642 compound sex,specificity
R1748 T5645 T5642 prep of,specificity
R1749 T5424 T5425 nsubj Analysis,failed
R1750 T5646 T5647 det this,cQTL
R1751 T5647 T5645 pobj cQTL,of
R1752 T5426 T5424 prep of,Analysis
R1753 T5648 T5598 punct .,was
R1754 T5650 T5651 det The,cQTL
R1755 T5427 T5428 det all,animals
R1756 T5428 T5426 pobj animals,of
R1757 T5651 T5652 nsubj cQTL,showed
R1758 T5429 T5424 prep with,Analysis
R1759 T5653 T5651 prep on,cQTL
R1760 T5654 T5653 pobj Chromosome,on
R1761 T5430 T5429 cc and,with
R1762 T5655 T5654 nummod 19,Chromosome
R1763 T5656 T5657 det a,effect
R1764 T5431 T5429 conj without,with
R1765 T5657 T5652 dobj effect,showed
R1766 T5658 T5659 npadvmod sex,specific
R1767 T5659 T5657 amod specific,effect
R1768 T5432 T5431 pobj sex,without
R1769 T5660 T5659 punct -,specific
R1770 T5661 T5652 prep in,showed
R1771 T5662 T5661 pobj females,in
R1772 T5433 T5432 prep as,sex
R1773 T5663 T5652 punct ", ",showed
R1774 T5664 T5652 prep with,showed
R1775 T5665 T5666 det no,effect
R1776 T5434 T5435 det a,covariate
R1777 T5666 T5664 pobj effect,with
R1778 T5667 T5666 prep in,effect
R1779 T5668 T5667 pobj males,in
R1780 T5435 T5433 pobj covariate,as
R1781 T5669 T5652 punct .,showed
R1782 T5671 T5672 advmod Overall,were
R1783 T5436 T5437 aux to,demonstrate
R1784 T5673 T5672 punct ", ",were
R1785 T5674 T5675 det all,cQTLs
R1786 T5437 T5425 xcomp demonstrate,failed
R1787 T5675 T5672 nsubj cQTLs,were
R1788 T5438 T5437 dobj evidence,demonstrate
R1789 T5676 T5675 nummod five,cQTLs
R1790 T5677 T5675 prep for,cQTLs
R1791 T5678 T5679 amod gonadal,mass
R1792 T5679 T5677 pobj mass,for
R1793 T5680 T5679 compound fat,mass
R1794 T5681 T5672 acomp biased,were
R1795 T5682 T5681 prep toward,biased
R1796 T5683 T5684 det a,effect
R1797 T5684 T5682 pobj effect,toward
R1798 T5685 T5684 amod larger,effect
R1799 T5686 T5672 prep in,were
R1800 T5687 T5686 pobj females,in
R1801 T5688 T5672 punct .,were
R1802 T5690 T5691 advcl Assuming,account
R1803 T5692 T5693 advmod purely,additive
R1804 T5693 T5694 amod additive,effects
R1805 T5694 T5690 dobj effects,Assuming
R1806 T5695 T5694 prep of,effects
R1807 T5696 T5697 det each,genotype
R1808 T5697 T5695 pobj genotype,of
R1809 T5698 T5691 punct ", ",account
R1810 T5699 T5700 det these,cQTLs
R1811 T5700 T5691 nsubj cQTLs,account
R1812 T5701 T5691 prep for,account
R1813 T5702 T5703 advmod approximately,42
R1814 T5703 T5704 nummod 42,%
R1815 T5704 T5701 pobj %,for
R1816 T5705 T5704 prep of,%
R1817 T5706 T5707 det the,variation
R1818 T5707 T5705 pobj variation,of
R1819 T5708 T5704 prep in,%
R1820 T5709 T5710 amod female,mice
R1821 T5710 T5708 pobj mice,in
R1822 T5711 T5710 compound F2,mice
R1823 T5712 T5704 cc and,%
R1824 T5713 T5714 nummod 13,%
R1825 T5714 T5704 conj %,%
R1826 T5715 T5714 prep in,%
R1827 T5716 T5715 pobj males,in
R1828 T5717 T5691 punct ", ",account
R1829 T5718 T5691 advcl consistent,account
R1830 T5719 T5718 prep with,consistent
R1831 T5720 T5721 det the,estimates
R1832 T5721 T5719 pobj estimates,with
R1833 T5722 T5721 amod narrow,estimates
R1834 T5723 T5721 compound sense,estimates
R1835 T5724 T5721 compound heritability,estimates
R1836 T5725 T5721 prep for,estimates
R1837 T5726 T5727 det this,trait
R1838 T5727 T5725 pobj trait,for
R1839 T5728 T5718 cc and,consistent
R1840 T5729 T5730 advmod again,demonstrating
R1841 T5730 T5718 conj demonstrating,consistent
R1842 T5731 T5732 amod significant,differences
R1843 T5732 T5730 dobj differences,demonstrating
R1844 T5733 T5732 prep in,differences
R1845 T5734 T5735 det the,regulation
R1846 T5735 T5733 pobj regulation,in
R1847 T5736 T5735 cc and,regulation
R1848 T5737 T5735 conj heritability,regulation
R1849 T5738 T5735 prep of,regulation
R1850 T5739 T5740 det the,trait
R1851 T5740 T5738 pobj trait,of
R1852 T5741 T5742 amod gonadal,fat
R1853 T5742 T5740 compound fat,trait
R1854 T5743 T5740 prep between,trait
R1855 T5744 T5745 det the,sexes
R1856 T5745 T5743 pobj sexes,between
R1857 T5746 T5691 punct .,account
R1859 T7352 T7353 compound Liver,eQTLs
R1860 T7355 T7356 nsubjpass Livers,profiled
R1861 T7357 T7355 prep from,Livers
R1862 T7358 T7359 nummod 312,animals
R1863 T7359 T7357 pobj animals,from
R1864 T7360 T7359 compound F2,animals
R1865 T7361 T7362 punct (,156
R1866 T7362 T7359 parataxis 156,animals
R1867 T7363 T7362 amod female,156
R1868 T7364 T7362 punct ", ",156
R1869 T7365 T7362 appos 156,156
R1870 T7366 T7365 amod male,156
R1871 T7367 T7362 punct ),156
R1872 T7368 T7356 auxpass were,profiled
R1873 T7369 T7356 advcl using,profiled
R1874 T7370 T7371 compound oligonucleotide,microarrays
R1875 T7371 T7369 dobj microarrays,using
R1876 T7372 T7371 acl manufactured,microarrays
R1877 T7373 T7372 agent by,manufactured
R1878 T7374 T7375 compound Agilent,Technologies
R1879 T7375 T7373 pobj Technologies,by
R1880 T7376 T7377 punct (,Alto
R1881 T7377 T7375 parataxis Alto,Technologies
R1882 T7378 T7377 compound Palo,Alto
R1883 T7379 T7377 punct ", ",Alto
R1884 T7380 T7377 npadvmod California,Alto
R1885 T7381 T7377 punct ", ",Alto
R1886 T7382 T7383 compound United,States
R1887 T7383 T7377 npadvmod States,Alto
R1888 T7384 T7377 punct ),Alto
R1889 T7385 T7375 punct ", ",Technologies
R1890 T7386 T7387 dep which,included
R1891 T7387 T7375 relcl included,Technologies
R1892 T7388 T7387 dobj probes,included
R1893 T7389 T7388 prep for,probes
R1894 T7390 T7391 nummod "23,574",transcripts
R1895 T7391 T7389 pobj transcripts,for
R1896 T7392 T7391 compound mouse,transcripts
R1897 T7393 T7356 punct .,profiled
R1898 T7395 T7396 amod Individual,intensities
R1899 T7396 T7398 nsubjpass intensities,corrected
R1900 T7397 T7396 compound transcript,intensities
R1901 T7399 T7398 auxpass were,corrected
R1902 T7400 T7398 prep for,corrected
R1903 T7401 T7402 amod experimental,variation
R1904 T7402 T7400 pobj variation,for
R1905 T7403 T7398 cc and,corrected
R1906 T7404 T7398 conj normalized,corrected
R1907 T7405 T7398 cc and,corrected
R1908 T7406 T7407 auxpass are,reported
R1909 T7407 T7398 conj reported,corrected
R1910 T7408 T7407 prep as,reported
R1911 T7409 T7410 det the,ratio
R1912 T7410 T7408 pobj ratio,as
R1913 T7411 T7410 compound mean,ratio
R1914 T7412 T7410 compound log10,ratio
R1915 T7413 T7410 punct (,ratio
R1916 T7414 T7410 appos mlratio,ratio
R1917 T7415 T7410 punct ),ratio
R1918 T7416 T7410 prep of,ratio
R1919 T7417 T7418 det an,experiment
R1920 T7418 T7416 pobj experiment,of
R1921 T7419 T7418 amod individual,experiment
R1922 T7420 T7410 amod relative,ratio
R1923 T7421 T7420 prep to,relative
R1924 T7422 T7423 det a,pool
R1925 T7423 T7421 pobj pool,to
R1926 T7424 T7423 acl composed,pool
R1927 T7425 T7424 prep of,composed
R1928 T7426 T7427 nummod 150,mice
R1929 T7427 T7425 pobj mice,of
R1930 T7428 T7429 advmod randomly,selected
R1931 T7429 T7427 acl selected,mice
R1932 T7430 T7429 prep from,selected
R1933 T7431 T7432 det the,population
R1934 T7432 T7430 pobj population,from
R1935 T7433 T7432 compound F2,population
R1936 T7434 T7435 punct [,21
R1937 T7435 T7407 parataxis 21,reported
R1938 T7436 T7435 punct ],21
R1939 T7437 T7398 punct .,corrected
R1940 T7439 T7440 det Each,measurement
R1941 T7440 T7441 nsubjpass measurement,fitted
R1942 T7442 T7441 auxpass was,fitted
R1943 T7443 T7441 prep to,fitted
R1944 T7444 T7445 det an,model
R1945 T7445 T7443 pobj model,to
R1946 T7446 T7445 compound error,model
R1947 T7447 T7441 cc and,fitted
R1948 T7448 T7441 conj assigned,fitted
R1949 T7449 T7450 det a,measurement
R1950 T7450 T7448 dobj measurement,assigned
R1951 T7451 T7450 compound significance,measurement
R1952 T7452 T7453 punct (,error
R1953 T7453 T7448 parataxis error,assigned
R1954 T7454 T7453 nmod type,error
R1955 T7455 T7454 nummod I,type
R1956 T7456 T7453 punct ),error
R1957 T7457 T7441 punct .,fitted
R1958 T7459 T7460 det A,map
R1959 T7460 T7462 nsubjpass map,depicted
R1960 T7461 T7460 compound heat,map
R1961 T7463 T7460 prep of,map
R1962 T7464 T7465 det the,transcripts
R1963 T7465 T7463 pobj transcripts,of
R1964 T7466 T7465 nummod "2,320",transcripts
R1965 T7467 T7468 advmod most,differentially
R1966 T7468 T7469 advmod differentially,expressed
R1967 T7469 T7465 acl expressed,transcripts
R1968 T7470 T7471 punct (,0.05
R1969 T7471 T7465 parataxis 0.05,transcripts
R1970 T7472 T7471 nsubj p,0.05
R1971 T7473 T7471 punct <,0.05
R1972 T7474 T7471 prep in,0.05
R1973 T7475 T7476 nummod 10,%
R1974 T7476 T7474 pobj %,in
R1975 T7477 T7476 cc or,%
R1976 T7478 T7476 conj more,%
R1977 T7479 T7476 prep of,%
R1978 T7480 T7479 pobj animals,of
R1979 T7481 T7471 punct ),0.05
R1980 T7482 T7460 amod relative,map
R1981 T7483 T7482 prep to,relative
R1982 T7484 T7485 det the,pool
R1983 T7485 T7483 pobj pool,to
R1984 T7486 T7462 auxpass is,depicted
R1985 T7487 T7462 prep in,depicted
R1986 T7488 T7487 pobj Figure,in
R1987 T7489 T7488 nummod 3,Figure
R1988 T7490 T7462 punct .,depicted
R1989 T7492 T7493 det This,selection
R1990 T7493 T7494 nsubj selection,was
R1991 T7495 T7493 prep of,selection
R1992 T7496 T7495 pobj genes,of
R1993 T7497 T7494 neg not,was
R1994 T7498 T7494 acomp biased,was
R1995 T7499 T7498 prep on,biased
R1996 T7500 T7501 advmod a,priori
R1997 T7501 T7502 amod priori,expression
R1998 T7502 T7499 pobj expression,on
R1999 T7503 T7502 amod known,expression
R2000 T7504 T7502 amod differential,expression
R2001 T7505 T7502 prep between,expression
R2002 T7506 T7507 det the,sexes
R2003 T7507 T7505 pobj sexes,between
R2004 T7508 T7502 punct ", ",expression
R2005 T7509 T7502 conj linkage,expression
R2006 T7510 T7509 punct ", ",linkage
R2007 T7511 T7509 cc or,linkage
R2008 T7512 T7509 conj correlation,linkage
R2009 T7513 T7512 prep with,correlation
R2010 T7514 T7515 det a,phenotype
R2011 T7515 T7513 pobj phenotype,with
R2012 T7516 T7515 amod clinical,phenotype
R2013 T7517 T7494 punct .,was
R2014 T7519 T7520 nsubj This,is
R2015 T7521 T7520 acomp noteworthy,is
R2016 T7522 T7523 mark because,shows
R2017 T7523 T7520 advcl shows,is
R2018 T7524 T7525 amod hierarchical,clustering
R2019 T7525 T7523 nsubj clustering,shows
R2020 T7526 T7525 prep of,clustering
R2021 T7527 T7528 det these,transcripts
R2022 T7528 T7526 pobj transcripts,of
R2023 T7529 T7525 prep against,clustering
R2024 T7530 T7531 det the,mice
R2025 T7531 T7529 pobj mice,against
R2026 T7532 T7531 nummod 312,mice
R2027 T7533 T7531 compound F2,mice
R2028 T7534 T7535 det an,clustering
R2029 T7535 T7523 dobj clustering,shows
R2030 T7536 T7537 advmod almost,perfect
R2031 T7537 T7535 amod perfect,clustering
R2032 T7538 T7535 prep into,clustering
R2033 T7539 T7540 amod male,subgroups
R2034 T7540 T7538 pobj subgroups,into
R2035 T7541 T7539 cc and,male
R2036 T7542 T7539 conj female,male
R2037 T7543 T7523 punct ", ",shows
R2038 T7544 T7523 advcl emphasizing,shows
R2039 T7545 T7546 amod striking,effects
R2040 T7546 T7544 dobj effects,emphasizing
R2041 T7547 T7546 prep of,effects
R2042 T7548 T7547 pobj sex,of
R2043 T7549 T7546 prep on,effects
R2044 T7550 T7551 compound liver,levels
R2045 T7551 T7549 pobj levels,on
R2046 T7552 T7553 compound gene,expression
R2047 T7553 T7551 compound expression,levels
R2048 T7554 T7544 cc and,emphasizing
R2049 T7555 T7544 conj suggesting,emphasizing
R2050 T7556 T7557 mark that,controlling
R2051 T7557 T7555 ccomp controlling,suggesting
R2052 T7558 T7557 nsubj sex,controlling
R2053 T7559 T7557 aux is,controlling
R2054 T7560 T7561 amod more,variance
R2055 T7561 T7557 dobj variance,controlling
R2056 T7562 T7561 prep in,variance
R2057 T7563 T7564 det these,transcripts
R2058 T7564 T7565 poss transcripts,expression
R2059 T7565 T7562 pobj expression,in
R2060 T7566 T7564 case ',transcripts
R2061 T7567 T7561 prep than,variance
R2062 T7568 T7569 det any,parameter
R2063 T7569 T7567 pobj parameter,than
R2064 T7570 T7569 amod other,parameter
R2065 T7571 T7520 punct .,is
R2066 T7573 T7574 det The,values
R2067 T7574 T7576 nsubjpass values,treated
R2068 T7575 T7574 compound expression,values
R2069 T7577 T7574 prep of,values
R2070 T7578 T7579 det the,transcripts
R2071 T7579 T7577 pobj transcripts,of
R2072 T7580 T7579 nummod "23,574",transcripts
R2073 T7581 T7576 auxpass were,treated
R2074 T7582 T7576 prep as,treated
R2075 T7583 T7584 amod quantitative,traits
R2076 T7584 T7582 pobj traits,as
R2077 T7585 T7576 cc and,treated
R2078 T7586 T7576 conj fitted,treated
R2079 T7587 T7586 prep to,fitted
R2080 T7588 T7589 det the,models
R2081 T7589 T7587 pobj models,to
R2082 T7590 T7589 amod same,models
R2083 T7591 T7592 amod linear,regression
R2084 T7592 T7589 compound regression,models
R2085 T7593 T7589 acl used,models
R2086 T7594 T7595 aux to,compute
R2087 T7595 T7593 advcl compute,used
R2088 T7596 T7597 compound LOD,scores
R2089 T7597 T7595 dobj scores,compute
R2090 T7598 T7595 prep for,compute
R2091 T7599 T7600 amod clinical,traits
R2092 T7600 T7598 pobj traits,for
R2093 T7601 T7602 punct (,eQTLs
R2094 T7602 T7600 parataxis eQTLs,traits
R2095 T7603 T7602 punct ),eQTLs
R2096 T7604 T7576 punct .,treated
R2097 T7606 T7607 det The,FDR
R2098 T7607 T7608 nsubjpass FDR,determined
R2099 T7609 T7607 prep at,FDR
R2100 T7610 T7611 det each,threshold
R2101 T7611 T7609 pobj threshold,at
R2102 T7612 T7608 auxpass was,determined
R2103 T7613 T7608 prep by,determined
R2104 T7614 T7613 pcomp permuting,by
R2105 T7615 T7616 det the,data
R2106 T7616 T7614 dobj data,permuting
R2107 T7617 T7618 nummod 100,times
R2108 T7618 T7614 npadvmod times,permuting
R2109 T7619 T7614 cc and,permuting
R2110 T7620 T7614 conj taking,permuting
R2111 T7621 T7622 det the,number
R2112 T7622 T7620 dobj number,taking
R2113 T7623 T7622 compound mean,number
R2114 T7624 T7622 prep of,number
R2115 T7625 T7624 pobj QTLs,of
R2116 T7626 T7625 acl detected,QTLs
R2117 T7627 T7620 prep over,taking
R2118 T7628 T7627 pobj all,over
R2119 T7629 T7628 prep of,all
R2120 T7630 T7631 det the,datasets
R2121 T7631 T7629 pobj datasets,of
R2122 T7632 T7631 amod permuted,datasets
R2123 T7633 T7628 prep at,all
R2124 T7634 T7635 det a,threshold
R2125 T7635 T7633 pobj threshold,at
R2126 T7636 T7635 amod given,threshold
R2127 T7637 T7620 punct ", ",taking
R2128 T7638 T7620 cc and,taking
R2129 T7639 T7620 conj dividing,taking
R2130 T7640 T7641 det this,count
R2131 T7641 T7639 dobj count,dividing
R2132 T7642 T7639 prep by,dividing
R2133 T7643 T7644 det the,number
R2134 T7644 T7642 pobj number,by
R2135 T7645 T7644 prep of,number
R2136 T7646 T7645 pobj QTLs,of
R2137 T7647 T7646 acl detected,QTLs
R2138 T7648 T7647 prep at,detected
R2139 T7649 T7650 det the,threshold
R2140 T7650 T7648 pobj threshold,at
R2141 T7651 T7650 amod same,threshold
R2142 T7652 T7650 prep in,threshold
R2143 T7653 T7654 det the,data
R2144 T7654 T7652 pobj data,in
R2145 T7655 T7654 amod observed,data
R2146 T7656 T7608 punct .,determined
R2147 T7658 T7659 prep At,estimated
R2148 T7660 T7661 det the,threshold
R2149 T7661 T7658 pobj threshold,At
R2150 T7662 T7661 prep for,threshold
R2151 T7663 T7664 amod significant,linkage
R2152 T7664 T7662 pobj linkage,for
R2153 T7665 T7666 punct (,0.05
R2154 T7666 T7661 parataxis 0.05,threshold
R2155 T7667 T7668 nsubj p,5
R2156 T7668 T7666 ccomp 5,0.05
R2157 T7669 T7668 punct <,5
R2158 T7670 T7668 punct ×,5
R2159 T7671 T7672 nummod 10,5
R2160 T7672 T7668 appos 5,5
R2161 T7673 T7672 punct −,5
R2162 T7674 T7666 punct ", ",0.05
R2163 T7675 T7676 nmod genome,p
R2164 T7676 T7666 nsubj p,0.05
R2165 T7677 T7676 punct -,p
R2166 T7678 T7676 amod wide,p
R2167 T7679 T7666 punct <,0.05
R2168 T7680 T7666 punct ", ",0.05
R2169 T7681 T7666 prep based,0.05
R2170 T7682 T7681 prep on,based
R2171 T7683 T7684 det a,trait
R2172 T7684 T7682 pobj trait,on
R2173 T7685 T7684 amod single,trait
R2174 T7686 T7666 punct ),0.05
R2175 T7687 T7659 punct ", ",estimated
R2176 T7688 T7689 det the,FDR
R2177 T7689 T7659 nsubjpass FDR,estimated
R2178 T7690 T7659 auxpass was,estimated
R2179 T7691 T7659 prep at,estimated
R2180 T7692 T7693 nummod 3.4,%
R2181 T7693 T7691 pobj %,at
R2182 T7694 T7659 prep for,estimated
R2183 T7695 T7696 det the,model
R2184 T7696 T7694 pobj model,for
R2185 T7697 T7696 amod standard,model
R2186 T7698 T7696 compound QTL,model
R2187 T7699 T7700 neg not,accounting
R2188 T7700 T7696 acl accounting,model
R2189 T7701 T7700 prep for,accounting
R2190 T7702 T7703 det any,terms
R2191 T7703 T7701 pobj terms,for
R2192 T7704 T7703 compound sex,terms
R2193 T7705 T7659 punct ", ",estimated
R2194 T7706 T7707 nummod 3.1,%
R2195 T7707 T7659 conj %,estimated
R2196 T7708 T7707 prep for,%
R2197 T7709 T7710 det the,model
R2198 T7710 T7708 pobj model,for
R2199 T7711 T7710 compound QTL,model
R2200 T7712 T7710 acl accounting,model
R2201 T7713 T7712 prep for,accounting
R2202 T7714 T7715 amod additive,effects
R2203 T7715 T7713 pobj effects,for
R2204 T7716 T7715 compound sex,effects
R2205 T7717 T7707 punct ", ",%
R2206 T7718 T7707 cc and,%
R2207 T7719 T7720 nummod 3.2,%
R2208 T7720 T7707 conj %,%
R2209 T7721 T7720 prep for,%
R2210 T7722 T7723 det the,model
R2211 T7723 T7721 pobj model,for
R2212 T7724 T7723 compound QTL,model
R2213 T7725 T7723 acl accounting,model
R2214 T7726 T7725 prep for,accounting
R2215 T7727 T7728 amod additive,effects
R2216 T7728 T7726 pobj effects,for
R2217 T7729 T7728 compound sex,effects
R2218 T7730 T7725 cc and,accounting
R2219 T7731 T7725 conj allowing,accounting
R2220 T7732 T7733 mark for,enter
R2221 T7733 T7731 advcl enter,allowing
R2222 T7734 T7735 det the,terms
R2223 T7735 T7733 nsubj terms,enter
R2224 T7736 T7737 compound sex,interaction
R2225 T7737 T7735 compound interaction,terms
R2226 T7738 T7733 aux to,enter
R2227 T7739 T7740 det the,model
R2228 T7740 T7733 dobj model,enter
R2229 T7741 T7659 punct .,estimated
R2230 T7743 T7744 det A,list
R2231 T7744 T7745 nsubjpass list,provided
R2232 T7746 T7744 prep of,list
R2233 T7747 T7748 det all,eQTLs
R2234 T7748 T7746 pobj eQTLs,of
R2235 T7749 T7748 amod detected,eQTLs
R2236 T7750 T7748 amod suggestive,eQTLs
R2237 T7751 T7752 punct (,3
R2238 T7752 T7750 parataxis 3,suggestive
R2239 T7753 T7752 nsubj p,3
R2240 T7754 T7752 punct <,3
R2241 T7755 T7752 quantmod 1,3
R2242 T7756 T7752 punct ×,3
R2243 T7757 T7752 quantmod 10,3
R2244 T7758 T7752 punct −,3
R2245 T7759 T7752 punct ),3
R2246 T7760 T7750 cc and,suggestive
R2247 T7761 T7750 conj significant,suggestive
R2248 T7762 T7763 punct (,5
R2249 T7763 T7748 parataxis 5,eQTLs
R2250 T7764 T7763 nsubj p,5
R2251 T7765 T7763 punct <,5
R2252 T7766 T7763 quantmod 5,5
R2253 T7767 T7763 punct ×,5
R2254 T7768 T7763 quantmod 10,5
R2255 T7769 T7763 punct −,5
R2256 T7770 T7763 punct ),5
R2257 T7771 T7748 acl detected,eQTLs
R2258 T7772 T7771 prep in,detected
R2259 T7773 T7774 det the,intercross
R2260 T7774 T7772 pobj intercross,in
R2261 T7775 T7774 nmod BXH.ApoE,intercross
R2262 T7776 T7775 punct −,BXH.ApoE
R2263 T7777 T7775 punct /,BXH.ApoE
R2264 T7778 T7775 punct −,BXH.ApoE
R2265 T7779 T7745 auxpass is,provided
R2266 T7780 T7745 prep in,provided
R2267 T7781 T7782 compound Table,S1
R2268 T7782 T7780 pobj S1,in
R2269 T7783 T7745 punct .,provided
R2270 T7785 T7786 nsubjpass Characteristics,summarized
R2271 T7787 T7785 prep of,Characteristics
R2272 T7788 T7789 det the,eQTLs
R2273 T7789 T7787 pobj eQTLs,of
R2274 T7790 T7785 prep at,Characteristics
R2275 T7791 T7792 amod different,levels
R2276 T7792 T7790 pobj levels,at
R2277 T7793 T7792 compound significance,levels
R2278 T7794 T7786 auxpass are,summarized
R2279 T7795 T7786 prep in,summarized
R2280 T7796 T7795 pobj Table,in
R2281 T7797 T7796 nummod 3,Table
R2282 T7798 T7786 cc and,summarized
R2283 T7799 T7786 conj shown,summarized
R2284 T7800 T7799 advmod graphically,shown
R2285 T7801 T7799 prep in,shown
R2286 T7802 T7801 pobj Figure,in
R2287 T7803 T7802 nummod 4,Figure
R2288 T7804 T7786 punct .,summarized
R2289 T7806 T7807 nsubj We,detected
R2290 T7808 T7809 nummod "6,676",eQTLs
R2291 T7809 T7807 dobj eQTLs,detected
R2292 T7810 T7809 acl representing,eQTLs
R2293 T7811 T7812 nummod "4,998",transcripts
R2294 T7812 T7810 dobj transcripts,representing
R2295 T7813 T7807 prep at,detected
R2296 T7814 T7815 det the,level
R2297 T7815 T7813 pobj level,at
R2298 T7816 T7815 nummod 5,level
R2299 T7817 T7816 punct ×,5
R2300 T7818 T7819 nummod 10,5
R2301 T7819 T7816 appos 5,5
R2302 T7820 T7819 punct −,5
R2303 T7821 T7815 amod significant,level
R2304 T7822 T7807 punct .,detected
R2305 T7824 T7825 prep Of,located
R2306 T7826 T7824 pobj these,Of
R2307 T7827 T7825 punct ", ",located
R2308 T7828 T7829 nummod "2,118",eQTLs
R2309 T7829 T7825 nsubjpass eQTLs,located
R2310 T7830 T7825 auxpass were,located
R2311 T7831 T7825 prep within,located
R2312 T7832 T7833 nummod 20,Mb
R2313 T7833 T7831 pobj Mb,within
R2314 T7834 T7833 punct (,Mb
R2315 T7835 T7836 advmod roughly,10
R2316 T7836 T7837 nummod 10,cM
R2317 T7837 T7833 appos cM,Mb
R2318 T7838 T7833 punct ),Mb
R2319 T7839 T7833 prep of,Mb
R2320 T7840 T7841 det the,gene
R2321 T7841 T7839 pobj gene,of
R2322 T7842 T7841 amod corresponding,gene
R2323 T7843 T7825 punct ", ",located
R2324 T7844 T7845 advmod likely,representing
R2325 T7845 T7825 advcl representing,located
R2326 T7846 T7845 dobj eQTLs,representing
R2327 T7847 T7846 acl regulated,eQTLs
R2328 T7848 T7847 agent by,regulated
R2329 T7849 T7850 npadvmod cis,acting
R2330 T7850 T7852 amod acting,variation
R2331 T7851 T7850 punct -,acting
R2332 T7852 T7848 pobj variation,by
R2333 T7853 T7847 prep within,regulated
R2334 T7854 T7855 det the,gene
R2335 T7855 T7853 pobj gene,within
R2336 T7856 T7855 appos itself,gene
R2337 T7857 T7825 punct .,located
R2338 T7859 T7860 prep Of,demonstrated
R2339 T7861 T7862 det the,eQTLs
R2340 T7862 T7859 pobj eQTLs,Of
R2341 T7863 T7862 nummod "6,676",eQTLs
R2342 T7864 T7862 amod significant,eQTLs
R2343 T7865 T7860 punct ", ",demonstrated
R2344 T7866 T7860 nsubj "1,166",demonstrated
R2345 T7867 T7868 punct (,%
R2346 T7868 T7866 parataxis %,"1,166"
R2347 T7869 T7868 nummod 17,%
R2348 T7870 T7868 punct ),%
R2349 T7871 T7872 det a,bias
R2350 T7872 T7860 dobj bias,demonstrated
R2351 T7873 T7872 compound sex,bias
R2352 T7874 T7860 cc and,demonstrated
R2353 T7875 T7876 auxpass were,improved
R2354 T7876 T7860 conj improved,demonstrated
R2355 T7877 T7876 advmod subsequently,improved
R2356 T7878 T7876 advmod significantly,improved
R2357 T7879 T7876 prep with,improved
R2358 T7880 T7881 det the,addition
R2359 T7881 T7879 pobj addition,with
R2360 T7882 T7881 prep of,addition
R2361 T7883 T7884 det the,terms
R2362 T7884 T7882 pobj terms,of
R2363 T7885 T7886 npadvmod sex,additive
R2364 T7886 T7884 amod additive,terms
R2365 T7887 T7886 punct -,additive
R2366 T7888 T7886 cc and,additive
R2367 T7889 T7890 npadvmod sex,dominant
R2368 T7890 T7886 conj dominant,additive
R2369 T7891 T7890 punct -,dominant
R2370 T7892 T7860 punct .,demonstrated
R2371 T7894 T7895 det "Table 3 Characteristics of Liver eQTLs Figure 4 Properties of All Liver eQTLs (A) Distribution of all significant liver eQTLs across the genome in 2-cM bins. A total of 6,676 significant eQTLs were realized, representing 4,998 liver transcripts. Hotspots of nonrandom eQTL colocalization are clearly evident. (B) Distribution of eQTLs with significant sex-specific effects. A total of 1,166 eQTLs representing 1,044 transcripts show an eQTL hotspot on Chromosome 5. (C) Properties of eQTLs at increasing significance levels. As the threshold for significant linkage increases (p-value decreases, or LOD score increases), the proportion of cis-eQTLs (black) increases. The fraction of all eQTLs with sex effects (red) and cis-eQTLs with sex effects (blue) remains relatively constant at increasing thresholds. The dashed line indicates the genome-wide significance threshold (p < 5 × 10−5; genome-wide p < 0.05). (D) Properties of sex-specific eQTLs at increasing significance levels. For eQTLs with significant sex effects, as with all eQTLs, the proportion of cis-eQTLs (black) increases and trans (blue) decreases as the threshold for significance increases. At the genome-wide threshold for significance (dashed line), over 70% of eQTLs with significant sex effects are trans. The",distribution
R2372 T7895 T7896 nsubjpass distribution,shown
R2373 T7897 T7895 prep of,distribution
R2374 T7898 T7899 det all,eQTLs
R2375 T7899 T7897 pobj eQTLs,of
R2376 T7900 T7899 nummod "6,676",eQTLs
R2377 T7901 T7899 amod significant,eQTLs
R2378 T7902 T7903 punct (,5
R2379 T7903 T7899 parataxis 5,eQTLs
R2380 T7904 T7903 nsubj p,5
R2381 T7905 T7903 punct <,5
R2382 T7906 T7903 punct ×,5
R2383 T7907 T7908 nummod 10,5
R2384 T7908 T7903 appos 5,5
R2385 T7909 T7908 punct −,5
R2386 T7910 T7903 punct ),5
R2387 T7911 T7895 prep across,distribution
R2388 T7912 T7913 det the,genome
R2389 T7913 T7911 pobj genome,across
R2390 T7914 T7895 prep in,distribution
R2391 T7915 T7916 nummod 2,cM
R2392 T7916 T7917 compound cM,bins
R2393 T7917 T7914 pobj bins,in
R2394 T7918 T7896 auxpass is,shown
R2395 T7919 T7896 prep in,shown
R2396 T7920 T7921 compound Figure,4A
R2397 T7921 T7919 pobj 4A,in
R2398 T7922 T7896 punct .,shown
R2399 T7924 T7925 nsubj Evidence,is
R2400 T7947 T7945 nsubj fractions,colocalize
R2401 T7926 T7924 prep for,Evidence
R2402 T7948 T7947 prep of,fractions
R2403 T7927 T7928 compound eQTL,hotspots
R2404 T7949 T7950 det the,eQTLs
R2405 T7950 T7948 pobj eQTLs,of
R2406 T7928 T7926 pobj hotspots,for
R2407 T7951 T7950 nummod "6,676",eQTLs
R2408 T7952 T7945 prep within,colocalize
R2409 T7929 T7925 acomp clear,is
R2410 T7953 T7954 nummod 2,cM
R2411 T7954 T7955 compound cM,regions
R2412 T7930 T7925 prep on,is
R2413 T7955 T7952 pobj regions,within
R2414 T7956 T7945 prep on,colocalize
R2415 T7957 T7958 det each,chromosome
R2416 T7931 T7932 nmod Chromosomes,1
R2417 T7958 T7956 pobj chromosome,on
R2418 T7959 T7925 punct .,is
R2419 T7932 T7930 pobj 1,on
R2420 T7961 T7962 advmod Approximately,67
R2421 T7933 T7932 punct ", ",1
R2422 T7962 T7963 nummod 67,%
R2423 T7963 T7964 nsubj %,are
R2424 T7934 T7932 conj 2,1
R2425 T7965 T7963 prep of,%
R2426 T7966 T7965 pobj eQTLs,of
R2427 T7935 T7934 punct ", ",2
R2428 T7967 T7966 prep at,eQTLs
R2429 T7968 T7969 det this,threshold
R2430 T7969 T7967 pobj threshold,at
R2431 T7970 T7964 attr trans,are
R2432 T7971 T7964 punct ", ",are
R2433 T7936 T7934 conj 4,2
R2434 T7972 T7964 cc and,are
R2435 T7973 T7974 det these,hotspots
R2436 T7974 T7976 nsubj hotspots,consist
R2437 T7975 T7974 compound eQTL,hotspots
R2438 T7937 T7936 punct ", ",4
R2439 T7976 T7964 conj consist,are
R2440 T7977 T7976 advmod primarily,consist
R2441 T7938 T7936 conj 5,4
R2442 T7978 T7976 prep of,consist
R2443 T7939 T7938 punct ", ",5
R2444 T7979 T7980 npadvmod trans,acting
R2445 T7980 T7982 amod acting,effects
R2446 T7981 T7980 punct -,acting
R2447 T7982 T7978 pobj effects,of
R2448 T7940 T7938 conj 6,5
R2449 T7983 T7982 prep on,effects
R2450 T7984 T7985 amod transcriptional,variation
R2451 T7985 T7983 pobj variation,on
R2452 T7941 T7940 punct ", ",6
R2453 T7986 T7976 punct .,consist
R2454 T7942 T7940 cc and,6
R2455 T7988 T7989 nsubj Distribution,showed
R2456 T7943 T7940 conj 7,6
R2457 T7990 T7988 prep of,Distribution
R2458 T7991 T7992 det the,eQTLs
R2459 T7992 T7990 pobj eQTLs,of
R2460 T7944 T7945 advmod where,colocalize
R2461 T7993 T7992 nummod "1,166",eQTLs
R2462 T7994 T7992 prep with,eQTLs
R2463 T7945 T7932 advcl colocalize,1
R2464 T7995 T7996 amod significant,effects
R2465 T7996 T7994 pobj effects,with
R2466 T7997 T7996 compound sex,effects
R2467 T7946 T7947 amod significant,fractions
R2468 T7998 T7992 punct ", ",eQTLs
R2469 T7999 T8000 prep of,are
R2470 T8053 T8052 pobj which,of
R2471 T8000 T7992 relcl are,eQTLs
R2472 T8001 T7999 pobj which,of
R2473 T8002 T8000 nsubj 852,are
R2474 T8054 T8055 compound genotype,sex
R2475 T8003 T8004 punct (,%
R2476 T8004 T8002 parataxis %,852
R2477 T8005 T8004 nummod 73,%
R2478 T8055 T8057 compound sex,interactions
R2479 T8006 T8004 punct ),%
R2480 T8007 T8000 attr trans,are
R2481 T8056 T8055 punct –,sex
R2482 T8008 T7989 punct ", ",showed
R2483 T8009 T7989 dobj enrichment,showed
R2484 T8057 T8051 dobj interactions,exhibited
R2485 T8010 T7989 prep on,showed
R2486 T8011 T8010 pobj Chromosome,on
R2487 T8012 T8011 nummod 5,Chromosome
R2488 T8058 T8043 punct .,were
R2489 T8013 T7989 prep at,showed
R2490 T8014 T8015 advmod approximately,49
R2491 T8060 T8061 prep At,were
R2492 T8015 T8016 nummod 49,cM
R2493 T8016 T8013 pobj cM,at
R2494 T8017 T8018 punct (,4B
R2495 T8062 T8063 amod increasing,thresholds
R2496 T8018 T7989 parataxis 4B,showed
R2497 T8019 T8018 compound Figure,4B
R2498 T8020 T8018 punct ),4B
R2499 T8021 T8022 mark as,assessed
R2500 T8063 T8060 pobj thresholds,At
R2501 T8022 T7989 advcl assessed,showed
R2502 T8023 T8022 advcl using,assessed
R2503 T8064 T8063 prep for,thresholds
R2504 T8024 T8025 det the,test
R2505 T8025 T8023 dobj test,using
R2506 T8026 T8025 nmod Fisher,test
R2507 T8065 T8064 pobj linkage,for
R2508 T8027 T8025 amod exact,test
R2509 T8028 T8029 punct (,8.7
R2510 T8029 T8025 parataxis 8.7,test
R2511 T8066 T8061 punct ", ",were
R2512 T8030 T8029 nsubj p,8.7
R2513 T8031 T8029 punct =,8.7
R2514 T8067 T8068 det a,fraction
R2515 T8032 T8029 punct ×,8.7
R2516 T8033 T8034 nummod 10,25
R2517 T8034 T8029 appos 25,8.7
R2518 T8068 T8061 nsubj fraction,were
R2519 T8035 T8034 punct −,25
R2520 T8036 T8029 prep after,8.7
R2521 T8037 T8038 compound Bonferroni,correction
R2522 T8069 T8068 amod higher,fraction
R2523 T8038 T8036 pobj correction,after
R2524 T8039 T8029 punct ),8.7
R2525 T8040 T7989 punct .,showed
R2526 T8070 T8068 prep of,fraction
R2527 T8042 T8043 prep At,were
R2528 T8071 T8072 amod detected,eQTLs
R2529 T8044 T8045 det this,locus
R2530 T8045 T8042 pobj locus,At
R2531 T8072 T8070 pobj eQTLs,of
R2532 T8046 T8043 expl there,were
R2533 T8047 T8048 nummod 250,eQTLs
R2534 T8048 T8043 attr eQTLs,were
R2535 T8049 T8048 punct ", ",eQTLs
R2536 T8050 T8051 dep 140,exhibited
R2537 T8073 T8074 npadvmod cis,acting
R2538 T8051 T8048 relcl exhibited,eQTLs
R2539 T8052 T8050 prep of,140
R2540 T8074 T8061 acomp acting,were
R2541 T8075 T8074 punct -,acting
R2542 T8076 T8077 punct (,4C
R2543 T8077 T8061 parataxis 4C,were
R2544 T8158 T8150 parataxis %,majority
R2545 T8078 T8077 compound Figure,4C
R2546 T8159 T8158 nummod 73,%
R2547 T8160 T8158 punct ),%
R2548 T8161 T8147 aux are,acting
R2549 T8079 T8077 punct ),4C
R2550 T8162 T8147 prep in,acting
R2551 T8163 T8162 pobj trans,in
R2552 T8164 T8147 prep on,acting
R2553 T8080 T8061 punct .,were
R2554 T8165 T8166 det a,gene
R2555 T8166 T8168 poss gene,expression
R2556 T8082 T8083 det The,proportion
R2557 T8167 T8166 amod given,gene
R2558 T8168 T8164 pobj expression,on
R2559 T8169 T8166 case 's,gene
R2560 T8170 T8171 punct (,4D
R2561 T8083 T8085 nsubjpass proportion,reported
R2562 T8171 T8147 parataxis 4D,acting
R2563 T8172 T8171 compound Figure,4D
R2564 T8173 T8171 punct ),4D
R2565 T8084 T8083 amod increased,proportion
R2566 T8174 T8147 punct ", ",acting
R2567 T8175 T8147 cc and,acting
R2568 T8176 T8177 amod similar,proportions
R2569 T8086 T8083 prep of,proportion
R2570 T8177 T8178 nsubj proportions,are
R2571 T8087 T8088 compound cis,eQTLs
R2572 T8178 T8147 conj are,acting
R2573 T8088 T8086 pobj eQTLs,of
R2574 T8179 T8177 prep of,proportions
R2575 T8180 T8181 npadvmod sex,specific
R2576 T8181 T8183 amod specific,eQTLs
R2577 T8089 T8088 punct -,eQTLs
R2578 T8182 T8181 punct -,specific
R2579 T8183 T8179 pobj eQTLs,of
R2580 T8090 T8088 prep with,eQTLs
R2581 T8184 T8185 punct (,%
R2582 T8185 T8177 parataxis %,proportions
R2583 T8186 T8185 nummod 26,%
R2584 T8187 T8185 punct ),%
R2585 T8188 T8178 attr cis,are
R2586 T8091 T8092 amod increasing,thresholds
R2587 T8189 T8178 prep compared,are
R2588 T8190 T8189 prep to,compared
R2589 T8191 T8192 det the,proportion
R2590 T8092 T8090 pobj thresholds,with
R2591 T8192 T8190 pobj proportion,to
R2592 T8193 T8192 prep of,proportion
R2593 T8194 T8195 det all,eQTLs
R2594 T8195 T8193 pobj eQTLs,of
R2595 T8093 T8092 compound LOD,thresholds
R2596 T8196 T8195 compound liver,eQTLs
R2597 T8197 T8195 compound cis,eQTLs
R2598 T8198 T8195 punct -,eQTLs
R2599 T8094 T8092 compound score,thresholds
R2600 T8199 T8200 punct (,%
R2601 T8200 T8178 parataxis %,are
R2602 T8201 T8200 nummod 32,%
R2603 T8095 T8085 aux has,reported
R2604 T8202 T8200 punct ),%
R2605 T8203 T8147 punct .,acting
R2606 T8096 T8085 auxpass been,reported
R2607 T8205 T8206 det These,data
R2608 T8206 T8207 nsubj data,demonstrate
R2609 T8097 T8085 advmod before,reported
R2610 T8208 T8209 det the,effects
R2611 T8209 T8207 dobj effects,demonstrate
R2612 T8098 T8099 punct [,15
R2613 T8210 T8209 amod profound,effects
R2614 T8211 T8209 prep of,effects
R2615 T8212 T8211 pobj sex,of
R2616 T8099 T8085 parataxis 15,reported
R2617 T8213 T8209 prep on,effects
R2618 T8214 T8215 det the,regulation
R2619 T8215 T8213 pobj regulation,on
R2620 T8100 T8099 nummod 5,15
R2621 T8216 T8215 amod genetic,regulation
R2622 T8217 T8215 prep of,regulation
R2623 T8218 T8219 compound gene,expression
R2624 T8101 T8099 punct ",",15
R2625 T8219 T8217 pobj expression,of
R2626 T8220 T8207 punct .,demonstrate
R2627 T8102 T8099 punct ],15
R2628 T8103 T8085 cc and,reported
R2629 T8104 T8085 conj confirms,reported
R2630 T8105 T8106 dep what,is
R2631 T8106 T8104 ccomp is,confirms
R2632 T8107 T8106 acomp likely,is
R2633 T8108 T8109 aux to,be
R2634 T8109 T8107 xcomp be,likely
R2635 T8110 T8111 poss our,power
R2636 T8111 T8109 attr power,be
R2637 T8112 T8111 amod increased,power
R2638 T8113 T8114 aux to,detect
R2639 T8114 T8111 acl detect,power
R2640 T8115 T8116 amod first,order
R2641 T8116 T8118 nmod order,variations
R2642 T8117 T8116 punct -,order
R2643 T8118 T8114 dobj variations,detect
R2644 T8119 T8120 npadvmod cis,acting
R2645 T8120 T8118 amod acting,variations
R2646 T8121 T8120 punct -,acting
R2647 T8122 T8118 acl affecting,variations
R2648 T8123 T8122 dobj transcription,affecting
R2649 T8124 T8085 punct .,reported
R2650 T8126 T8127 det The,proportion
R2651 T8127 T8128 nsubj proportion,remained
R2652 T8129 T8127 prep of,proportion
R2653 T8130 T8129 pobj eQTLs,of
R2654 T8131 T8130 prep with,eQTLs
R2655 T8132 T8133 amod significant,effects
R2656 T8133 T8131 pobj effects,with
R2657 T8134 T8133 compound sex,effects
R2658 T8135 T8136 advmod relatively,constant
R2659 T8136 T8128 acomp constant,remained
R2660 T8137 T8128 prep at,remained
R2661 T8138 T8139 det all,thresholds
R2662 T8139 T8137 pobj thresholds,at
R2663 T8140 T8141 punct (,4C
R2664 T8141 T8128 parataxis 4C,remained
R2665 T8142 T8141 compound Figure,4C
R2666 T8143 T8141 punct ),4C
R2667 T8144 T8128 punct .,remained
R2668 T8146 T8147 advmod Furthermore,acting
R2669 T8148 T8147 punct ", ",acting
R2670 T8149 T8150 det the,majority
R2671 T8150 T8147 nsubj majority,acting
R2672 T8151 T8150 prep of,majority
R2673 T8152 T8153 det these,eQTLs
R2674 T8153 T8151 pobj eQTLs,of
R2675 T8154 T8155 npadvmod sex,specific
R2676 T8155 T8153 amod specific,eQTLs
R2677 T8156 T8155 punct -,specific
R2678 T8157 T8158 punct (,%
R52 T593 T592 amod genetical,analyses
R53 T594 T592 amod genomic,analyses
R2 T537 T534 cc and,Genetic
R3 T538 T534 conj Genomic,Genetic
R7 T543 T544 compound Fat,Mass
R8 T544 T542 compound Mass,Trait
R14 T550 T549 compound Sex,Specificity
R36 T576 T574 prep of,effects
R37 T577 T576 pobj gender,of
R38 T578 T574 prep on,effects
R39 T579 T580 det the,regulation
R40 T580 T578 pobj regulation,on
R41 T581 T580 prep of,regulation
R42 T582 T583 amod many,traits
R54 T595 T592 punct ”,analyses
R62 T603 T601 pobj which,to
R63 T604 T605 poss their,conclusions
R64 T605 T602 nsubjpass conclusions,affected
R65 T606 T602 auxpass are,affected
R75 T618 T617 amod large,intercross
R76 T619 T617 compound F2,intercross
R81 T624 T623 amod inbred,strains
R82 T625 T623 compound mouse,strains
R85 T628 T627 punct /,6J
R89 T632 T631 punct /,HeJ
R93 T636 T637 compound apolipoprotein,E
R94 T637 T638 npadvmod E,null
R95 T638 T635 amod null,background
R96 T639 T640 punct (,ApoE
R97 T640 T638 parataxis ApoE,null
R98 T641 T640 punct −,ApoE
R99 T642 T640 punct /,ApoE
R100 T643 T640 punct −,ApoE
R101 T644 T640 punct ),ApoE
R105 T649 T648 nmod BXH.ApoE,population
R106 T650 T649 punct −,BXH.ApoE
R107 T651 T649 punct /,BXH.ApoE
R108 T652 T649 punct −,BXH.ApoE
R111 T656 T655 punct “,phenotypes
R112 T657 T658 amod metabolic,syndrome
R113 T658 T655 nmod syndrome,phenotypes
R114 T659 T655 punct ”,phenotypes
R128 T675 T674 aux to,test
R129 T676 T674 advmod specifically,test
R142 T691 T690 nmod liver,loci
R143 T692 T693 nmod gene,expression
R144 T693 T690 nmod expression,loci
R145 T694 T695 amod quantitative,trait
R146 T695 T690 compound trait,loci
R150 T699 T698 amod significant,proportion
R152 T701 T698 prep of,proportion
R153 T702 T701 pobj which,of
R156 T705 T704 punct -,biased
R168 T719 T718 compound fat,mass
R172 T723 T722 amod complex,trait
R176 T727 T726 punct -,specific
R184 T737 T738 advmod remarkably,high
R185 T738 T736 amod high,degree
R189 T742 T741 punct -,dependence
R193 T746 T745 det the,cis
R204 T759 T760 det these,analyses
R205 T760 T758 nsubjpass analyses,applied
R206 T761 T758 aux can,applied
R207 T762 T758 auxpass be,applied
R217 T772 T771 compound fat,mass
R221 T776 T775 amod complex,trait
R225 T780 T779 amod female,biased
R226 T781 T779 punct -,biased
R235 T792 T791 amod potential,effects
R241 T798 T797 amod genetic,regulation
R245 T802 T801 amod complex,traits
R7208 T22450 T22440 cc and,motivated
R7209 T22451 T22452 det these,results
R7210 T22452 T22453 nsubj results,motivate
R7211 T22453 T22440 conj motivate,motivated
R7212 T22454 T22453 advmod further,motivate
R7213 T22455 T22456 det the,need
R7214 T22456 T22453 dobj need,motivate
R7215 T22457 T22458 aux to,explore
R7216 T22458 T22456 acl explore,need
R7217 T22459 T22460 compound sex,effects
R7218 T22460 T22458 dobj effects,explore
R7219 T22461 T22458 prep by,explore
R7220 T22462 T22461 pcomp employing,by
R7221 T22463 T22464 advmod even,more
R7222 T22464 T22465 advmod more,sophisticated
R7223 T22465 T22466 amod sophisticated,methods
R7224 T22466 T22462 dobj methods,employing
R7225 T22467 T22468 compound QTL,detection
R7226 T22468 T22466 compound detection,methods
R7227 T22469 T22466 punct ", ",methods
R7228 T22470 T22471 amod such,as
R7229 T22471 T22466 prep as,methods
R7230 T22472 T22471 pobj that,as
R7231 T22473 T22474 advmod recently,described
R7232 T22474 T22472 acl described,that
R7233 T22475 T22474 agent by,described
R7234 T22476 T22475 pobj Yi,by
R7235 T22477 T22478 advmod et,al.
R7236 T22478 T22476 advmod al.,Yi
R7237 T22479 T22480 punct [,38
R7238 T22480 T22476 parataxis 38,Yi
R7239 T22481 T22480 punct ],38
R7240 T22482 T22453 punct .,motivate