PMC:1315279 / 3043-48409 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1057	13-19	IN	denotes	During
T1058	86-93	VBN	denotes	favored
T1059	20-28	JJ	denotes	skeletal
T1060	29-40	NN	denotes	development
T1061	40-42	,	denotes	,
T1062	42-45	DT	denotes	the
T1063	55-63	NN	denotes	activity
T1064	46-54	JJ	denotes	anabolic
T1065	64-66	IN	denotes	of
T1066	67-78	NNS	denotes	osteoblasts
T1067	79-80	-LRB-	denotes	[
T1068	80-81	CD	denotes	1
T1069	81-82	-RRB-	denotes	]
T1070	83-85	VBZ	denotes	is
T1071	94-98	IN	denotes	over
T1072	99-102	DT	denotes	the
T1073	113-121	NN	denotes	activity
T1074	103-112	JJ	denotes	catabolic
T1075	122-124	IN	denotes	of
T1076	125-136	NNS	denotes	osteoclasts
T1077	137-138	-LRB-	denotes	[
T1078	138-139	CD	denotes	2
T1079	139-140	-RRB-	denotes	]
T1080	140-142	,	denotes	,
T1081	142-147	WDT	denotes	which
T1082	148-155	VBZ	denotes	results
T1083	156-158	IN	denotes	in
T1084	159-160	DT	denotes	a
T1085	165-169	NN	denotes	gain
T1086	161-164	JJ	denotes	net
T1087	170-172	IN	denotes	in
T1088	173-177	NN	denotes	bone
T1089	178-182	NN	denotes	mass
T1090	182-183	.	denotes	.
T1091	183-319	sentence	denotes	At skeletal maturity, bone mass is maintained through the balanced activity of osteoblasts and osteoclasts during the remodeling cycle.
T1092	184-186	IN	denotes	At
T1093	219-229	VBN	denotes	maintained
T1094	187-195	JJ	denotes	skeletal
T1095	196-204	NN	denotes	maturity
T1096	204-206	,	denotes	,
T1097	206-210	NN	denotes	bone
T1098	211-215	NN	denotes	mass
T1099	216-218	VBZ	denotes	is
T1100	230-237	IN	denotes	through
T1101	238-241	DT	denotes	the
T1102	251-259	NN	denotes	activity
T1103	242-250	VBN	denotes	balanced
T1104	260-262	IN	denotes	of
T1105	263-274	NNS	denotes	osteoblasts
T1106	275-278	CC	denotes	and
T1107	279-290	NNS	denotes	osteoclasts
T1108	291-297	IN	denotes	during
T1109	298-301	DT	denotes	the
T1110	313-318	NN	denotes	cycle
T1111	302-312	NN	denotes	remodeling
T1112	318-319	.	denotes	.
T1113	319-459	sentence	denotes	During skeletal aging, there is a shift in the balance that favors osteoclast over osteoblast activity, which results in net bone loss [3].
T1114	320-326	IN	denotes	During
T1115	349-351	VBZ	denotes	is
T1116	327-335	JJ	denotes	skeletal
T1117	336-341	NN	denotes	aging
T1118	341-343	,	denotes	,
T1119	343-348	EX	denotes	there
T1120	352-353	DT	denotes	a
T1121	354-359	NN	denotes	shift
T1122	360-362	IN	denotes	in
T1123	363-366	DT	denotes	the
T1124	367-374	NN	denotes	balance
T1125	375-379	WDT	denotes	that
T1126	380-386	VBZ	denotes	favors
T1127	387-397	NN	denotes	osteoclast
T1128	398-402	IN	denotes	over
T1129	403-413	NN	denotes	osteoblast
T1130	414-422	NN	denotes	activity
T1131	422-424	,	denotes	,
T1132	424-429	WDT	denotes	which
T1133	430-437	VBZ	denotes	results
T1134	438-440	IN	denotes	in
T1135	441-444	JJ	denotes	net
T1136	450-454	NN	denotes	loss
T1137	445-449	NN	denotes	bone
T1138	455-456	-LRB-	denotes	[
T1139	456-457	CD	denotes	3
T1140	457-458	-RRB-	denotes	]
T1141	458-459	.	denotes	.
T1142	459-761	sentence	denotes	The amount and rate at which bone is gained during development and lost during aging are determined in large part by genetics [4–6] but also by physical activity and by alterations in the availability and response of bone cells to circulating hormones [7–9] and locally derived growth factors [10,11].
T1143	460-463	DT	denotes	The
T1144	464-470	NN	denotes	amount
T1145	549-559	VBN	denotes	determined
T1146	471-474	CC	denotes	and
T1147	475-479	NN	denotes	rate
T1148	480-482	IN	denotes	at
T1149	497-503	VBN	denotes	gained
T1150	483-488	WDT	denotes	which
T1151	489-493	NN	denotes	bone
T1152	494-496	VBZ	denotes	is
T1153	504-510	IN	denotes	during
T1154	511-522	NN	denotes	development
T1155	523-526	CC	denotes	and
T1156	527-531	VBN	denotes	lost
T1157	532-538	IN	denotes	during
T1158	539-544	NN	denotes	aging
T1159	545-548	VBP	denotes	are
T1160	560-562	IN	denotes	in
T1161	563-568	JJ	denotes	large
T1162	569-573	NN	denotes	part
T1163	574-576	IN	denotes	by
T1164	577-585	NN	denotes	genetics
T1165	586-587	-LRB-	denotes	[
T1166	587-588	CD	denotes	4
T1167	588-589	SYM	denotes	–
T1168	589-590	CD	denotes	6
T1169	590-591	-RRB-	denotes	]
T1170	592-595	CC	denotes	but
T1171	596-600	RB	denotes	also
T1172	601-603	IN	denotes	by
T1173	604-612	JJ	denotes	physical
T1174	613-621	NN	denotes	activity
T1175	622-625	CC	denotes	and
T1176	626-628	IN	denotes	by
T1177	629-640	NNS	denotes	alterations
T1178	641-643	IN	denotes	in
T1179	644-647	DT	denotes	the
T1180	648-660	NN	denotes	availability
T1181	661-664	CC	denotes	and
T1182	665-673	NN	denotes	response
T1183	674-676	IN	denotes	of
T1184	677-681	NN	denotes	bone
T1185	682-687	NNS	denotes	cells
T1186	688-690	IN	denotes	to
T1187	691-702	VBG	denotes	circulating
T1188	703-711	NNS	denotes	hormones
T1189	712-713	-LRB-	denotes	[
T1190	713-714	CD	denotes	7
T1191	714-715	SYM	denotes	–
T1192	715-716	CD	denotes	9
T1193	716-717	-RRB-	denotes	]
T1194	718-721	CC	denotes	and
T1195	722-729	RB	denotes	locally
T1196	730-737	VBN	denotes	derived
T1197	745-752	NNS	denotes	factors
T1198	738-744	NN	denotes	growth
T1199	753-754	-LRB-	denotes	[
T1200	757-759	CD	denotes	11
T1201	754-756	CD	denotes	10
T1202	756-757	,	denotes	,
T1203	759-760	-RRB-	denotes	]
T1204	760-761	.	denotes	.
T1205	761-950	sentence	denotes	Whereas genetic-based studies have provided novel insights into the pathways that regulate bone development [12–14], relatively little is known about the etiology of age-related bone loss.
T1206	762-769	IN	denotes	Whereas
T1207	797-805	VBN	denotes	provided
T1208	770-777	JJ	denotes	genetic
T1209	778-783	VBN	denotes	based
T1210	777-778	HYPH	denotes	-
T1211	784-791	NNS	denotes	studies
T1212	792-796	VBP	denotes	have
T1213	900-905	VBN	denotes	known
T1214	806-811	JJ	denotes	novel
T1215	812-820	NNS	denotes	insights
T1216	821-825	IN	denotes	into
T1217	826-829	DT	denotes	the
T1218	830-838	NNS	denotes	pathways
T1219	839-843	WDT	denotes	that
T1220	844-852	VBP	denotes	regulate
T1221	853-857	NN	denotes	bone
T1222	858-869	NN	denotes	development
T1223	870-871	-LRB-	denotes	[
T1224	871-873	CD	denotes	12
T1225	873-874	SYM	denotes	–
T1226	874-876	CD	denotes	14
T1227	876-877	-RRB-	denotes	]
T1228	877-879	,	denotes	,
T1229	879-889	RB	denotes	relatively
T1230	890-896	JJ	denotes	little
T1231	897-899	VBZ	denotes	is
T1232	906-911	IN	denotes	about
T1233	912-915	DT	denotes	the
T1234	916-924	NN	denotes	etiology
T1235	925-927	IN	denotes	of
T1236	928-931	NN	denotes	age
T1237	932-939	VBN	denotes	related
T1238	931-932	HYPH	denotes	-
T1239	945-949	NN	denotes	loss
T1240	940-944	NN	denotes	bone
T1241	949-950	.	denotes	.
T1242	950-1108	sentence	denotes	Increased bone resorption in elderly men and women is associated with a reduction in bone mass and an increase in circulating levels of bone biomarkers [15].
T1243	951-960	VBN	denotes	Increased
T1244	966-976	NN	denotes	resorption
T1245	961-965	NN	denotes	bone
T1246	1005-1015	VBN	denotes	associated
T1247	977-979	IN	denotes	in
T1248	980-987	JJ	denotes	elderly
T1249	988-991	NNS	denotes	men
T1250	992-995	CC	denotes	and
T1251	996-1001	NNS	denotes	women
T1252	1002-1004	VBZ	denotes	is
T1253	1016-1020	IN	denotes	with
T1254	1021-1022	DT	denotes	a
T1255	1023-1032	NN	denotes	reduction
T1256	1033-1035	IN	denotes	in
T1257	1036-1040	NN	denotes	bone
T1258	1041-1045	NN	denotes	mass
T1259	1046-1049	CC	denotes	and
T1260	1050-1052	DT	denotes	an
T1261	1053-1061	NN	denotes	increase
T1262	1062-1064	IN	denotes	in
T1263	1065-1076	VBG	denotes	circulating
T1264	1077-1083	NNS	denotes	levels
T1265	1084-1086	IN	denotes	of
T1266	1087-1091	NN	denotes	bone
T1267	1092-1102	NNS	denotes	biomarkers
T1268	1103-1104	-LRB-	denotes	[
T1269	1104-1106	CD	denotes	15
T1270	1106-1107	-RRB-	denotes	]
T1271	1107-1108	.	denotes	.
T1272	1108-1397	sentence	denotes	These changes have been attributed primarily to nutritional deficits resulting in alterations in the parathyroid hormone–vitamin D axis [16], to gonadal hormone deficiency [17], to leptin levels and the sympathetic nervous system [8,18–20], and to alterations in bone cell apoptosis [21].
T1273	1109-1114	DT	denotes	These
T1274	1115-1122	NNS	denotes	changes
T1275	1133-1143	VBN	denotes	attributed
T1276	1123-1127	VBP	denotes	have
T1277	1128-1132	VBN	denotes	been
T1278	1144-1153	RB	denotes	primarily
T1279	1154-1156	IN	denotes	to
T1280	1157-1168	JJ	denotes	nutritional
T1281	1169-1177	NNS	denotes	deficits
T1282	1178-1187	VBG	denotes	resulting
T1283	1188-1190	IN	denotes	in
T1284	1191-1202	NNS	denotes	alterations
T1285	1203-1205	IN	denotes	in
T1286	1206-1209	DT	denotes	the
T1287	1240-1244	NN	denotes	axis
T1288	1210-1221	NN	denotes	parathyroid
T1289	1222-1229	NN	denotes	hormone
T1290	1229-1230	HYPH	denotes	–
T1291	1230-1237	NN	denotes	vitamin
T1292	1238-1239	NN	denotes	D
T1293	1245-1246	-LRB-	denotes	[
T1294	1246-1248	CD	denotes	16
T1295	1248-1249	-RRB-	denotes	]
T1296	1249-1251	,	denotes	,
T1297	1251-1253	IN	denotes	to
T1298	1254-1261	JJ	denotes	gonadal
T1299	1270-1280	NN	denotes	deficiency
T1300	1262-1269	NN	denotes	hormone
T1301	1281-1282	-LRB-	denotes	[
T1302	1282-1284	CD	denotes	17
T1303	1284-1285	-RRB-	denotes	]
T1304	1285-1287	,	denotes	,
T1305	1287-1289	IN	denotes	to
T1306	1290-1296	NN	denotes	leptin
T1307	1297-1303	NNS	denotes	levels
T1308	1304-1307	CC	denotes	and
T1309	1308-1311	DT	denotes	the
T1310	1332-1338	NN	denotes	system
T1311	1312-1323	JJ	denotes	sympathetic
T1312	1324-1331	JJ	denotes	nervous
T1313	1339-1340	-LRB-	denotes	[
T1314	1340-1341	CD	denotes	8
T1315	1341-1342	,	denotes	,
T1316	1342-1344	CD	denotes	18
T1317	1344-1345	SYM	denotes	–
T1318	1345-1347	CD	denotes	20
T1319	1347-1348	-RRB-	denotes	]
T1320	1348-1350	,	denotes	,
T1321	1350-1353	CC	denotes	and
T1322	1354-1356	IN	denotes	to
T1323	1357-1368	NNS	denotes	alterations
T1324	1369-1371	IN	denotes	in
T1325	1372-1376	NN	denotes	bone
T1326	1377-1381	NN	denotes	cell
T1327	1382-1391	NN	denotes	apoptosis
T1328	1392-1393	-LRB-	denotes	[
T1329	1393-1395	CD	denotes	21
T1330	1395-1396	-RRB-	denotes	]
T1331	1396-1397	.	denotes	.
T1332	1397-1629	sentence	denotes	Bone loss in the elderly has also been attributed to alterations in the response of bone marrow stromal cells to their microenvironment that favors differentiation down the adipocyte lineage rather than the osteoblast lineage [22].
T1333	1398-1402	NN	denotes	Bone
T1334	1403-1407	NN	denotes	loss
T1335	1437-1447	VBN	denotes	attributed
T1336	1408-1410	IN	denotes	in
T1337	1411-1414	DT	denotes	the
T1338	1415-1422	JJ	denotes	elderly
T1339	1423-1426	VBZ	denotes	has
T1340	1427-1431	RB	denotes	also
T1341	1432-1436	VBN	denotes	been
T1342	1448-1450	IN	denotes	to
T1343	1451-1462	NNS	denotes	alterations
T1344	1463-1465	IN	denotes	in
T1345	1466-1469	DT	denotes	the
T1346	1470-1478	NN	denotes	response
T1347	1479-1481	IN	denotes	of
T1348	1482-1486	NN	denotes	bone
T1349	1487-1493	NN	denotes	marrow
T1350	1502-1507	NNS	denotes	cells
T1351	1494-1501	JJ	denotes	stromal
T1352	1508-1510	IN	denotes	to
T1353	1511-1516	PRP$	denotes	their
T1354	1517-1533	NN	denotes	microenvironment
T1355	1534-1538	WDT	denotes	that
T1356	1539-1545	VBZ	denotes	favors
T1357	1546-1561	NN	denotes	differentiation
T1358	1562-1566	IN	denotes	down
T1359	1567-1570	DT	denotes	the
T1360	1581-1588	NN	denotes	lineage
T1361	1571-1580	NN	denotes	adipocyte
T1362	1589-1595	RB	denotes	rather
T1363	1596-1600	IN	denotes	than
T1364	1601-1604	DT	denotes	the
T1365	1616-1623	NN	denotes	lineage
T1366	1605-1615	NN	denotes	osteoblast
T1367	1624-1625	-LRB-	denotes	[
T1368	1625-1627	CD	denotes	22
T1369	1627-1628	-RRB-	denotes	]
T1370	1628-1629	.	denotes	.
T1371	1629-1761	sentence	denotes	Aging has long been associated with an increase in marrow fat, where the generation of adipocytes is favored over osteoblasts [23].
T1372	1630-1635	NN	denotes	Aging
T1373	1650-1660	VBN	denotes	associated
T1374	1636-1639	VBZ	denotes	has
T1375	1640-1644	RB	denotes	long
T1376	1645-1649	VBN	denotes	been
T1377	1661-1665	IN	denotes	with
T1378	1666-1668	DT	denotes	an
T1379	1669-1677	NN	denotes	increase
T1380	1678-1680	IN	denotes	in
T1381	1681-1687	NN	denotes	marrow
T1382	1688-1691	NN	denotes	fat
T1383	1691-1693	,	denotes	,
T1384	1693-1698	WRB	denotes	where
T1385	1731-1738	VBN	denotes	favored
T1386	1699-1702	DT	denotes	the
T1387	1703-1713	NN	denotes	generation
T1388	1714-1716	IN	denotes	of
T1389	1717-1727	NNS	denotes	adipocytes
T1390	1728-1730	VBZ	denotes	is
T1391	1739-1743	IN	denotes	over
T1392	1744-1755	NNS	denotes	osteoblasts
T1393	1756-1757	-LRB-	denotes	[
T1394	1757-1759	CD	denotes	23
T1395	1759-1760	-RRB-	denotes	]
T1396	1760-1761	.	denotes	.
T1397	1761-1981	sentence	denotes	Osteoblasts and adipocytes are derived from a common mesenchymal precursor cell present in bone marrow, and the factors that control this age-induced switch toward adipogenic differentiation is not well understood [24].
T1398	1762-1773	NNS	denotes	Osteoblasts
T1399	1793-1800	VBN	denotes	derived
T1400	1774-1777	CC	denotes	and
T1401	1778-1788	NNS	denotes	adipocytes
T1402	1789-1792	VBP	denotes	are
T1403	1801-1805	IN	denotes	from
T1404	1806-1807	DT	denotes	a
T1405	1837-1841	NN	denotes	cell
T1406	1808-1814	JJ	denotes	common
T1407	1815-1826	JJ	denotes	mesenchymal
T1408	1827-1836	NN	denotes	precursor
T1409	1842-1849	JJ	denotes	present
T1410	1850-1852	IN	denotes	in
T1411	1853-1857	NN	denotes	bone
T1412	1858-1864	NN	denotes	marrow
T1413	1864-1866	,	denotes	,
T1414	1866-1869	CC	denotes	and
T1415	1870-1873	DT	denotes	the
T1416	1874-1881	NNS	denotes	factors
T1417	1965-1975	VBN	denotes	understood
T1418	1882-1886	WDT	denotes	that
T1419	1887-1894	VBP	denotes	control
T1420	1895-1899	DT	denotes	this
T1421	1912-1918	NN	denotes	switch
T1422	1900-1903	NN	denotes	age
T1423	1904-1911	VBN	denotes	induced
T1424	1903-1904	HYPH	denotes	-
T1425	1919-1925	IN	denotes	toward
T1426	1926-1936	JJ	denotes	adipogenic
T1427	1937-1952	NN	denotes	differentiation
T1428	1953-1955	VBZ	denotes	is
T1429	1956-1959	RB	denotes	not
T1430	1960-1964	RB	denotes	well
T1431	1976-1977	-LRB-	denotes	[
T1432	1977-1979	CD	denotes	24
T1433	1979-1980	-RRB-	denotes	]
T1434	1980-1981	.	denotes	.
T1435	1981-2262	sentence	denotes	While several transcriptional regulatory proteins have been associated with cell fate determination of bone marrow mesenchymal cells, including peroxisome proliferator–activated receptor γ (PPARγ) and KLF5 [25–30], the role of RNA binding proteins in this process remains unknown.
T1436	1982-1987	IN	denotes	While
T1437	2042-2052	VBN	denotes	associated
T1438	1988-1995	JJ	denotes	several
T1439	2023-2031	NN	denotes	proteins
T1440	1996-2011	JJ	denotes	transcriptional
T1441	2012-2022	JJ	denotes	regulatory
T1442	2032-2036	VBP	denotes	have
T1443	2037-2041	VBN	denotes	been
T1444	2246-2253	VBZ	denotes	remains
T1445	2053-2057	IN	denotes	with
T1446	2058-2062	NN	denotes	cell
T1447	2068-2081	NN	denotes	determination
T1448	2063-2067	NN	denotes	fate
T1449	2082-2084	IN	denotes	of
T1450	2085-2089	NN	denotes	bone
T1451	2090-2096	NN	denotes	marrow
T1452	2109-2114	NNS	denotes	cells
T1453	2097-2108	JJ	denotes	mesenchymal
T1454	2114-2116	,	denotes	,
T1455	2116-2125	VBG	denotes	including
T1456	2126-2136	NN	denotes	peroxisome
T1457	2160-2168	NN	denotes	receptor
T1458	2137-2149	NN	denotes	proliferator
T1459	2150-2159	VBN	denotes	activated
T1460	2149-2150	HYPH	denotes	–
T1461	2169-2170	SYM	denotes	γ
T1462	2171-2172	-LRB-	denotes	(
T1463	2172-2177	NN	denotes	PPARγ
T1464	2177-2178	-RRB-	denotes	)
T1465	2179-2182	CC	denotes	and
T1466	2183-2187	NN	denotes	KLF5
T1467	2188-2189	-LRB-	denotes	[
T1468	2189-2191	CD	denotes	25
T1469	2191-2192	SYM	denotes	–
T1470	2192-2194	CD	denotes	30
T1471	2194-2195	-RRB-	denotes	]
T1472	2195-2197	,	denotes	,
T1473	2197-2200	DT	denotes	the
T1474	2201-2205	NN	denotes	role
T1475	2206-2208	IN	denotes	of
T1476	2209-2212	NN	denotes	RNA
T1477	2221-2229	NN	denotes	proteins
T1478	2213-2220	NN	denotes	binding
T1479	2230-2232	IN	denotes	in
T1480	2233-2237	DT	denotes	this
T1481	2238-2245	NN	denotes	process
T1482	2254-2261	JJ	denotes	unknown
T1483	2261-2262	.	denotes	.
T1484	2262-2348	sentence	denotes	RNA binding proteins of the KH type are known regulators of cellular differentiation.
T1485	2263-2266	NN	denotes	RNA
T1486	2275-2283	NN	denotes	proteins
T1487	2267-2274	NN	denotes	binding
T1488	2299-2302	VBP	denotes	are
T1489	2284-2286	IN	denotes	of
T1490	2287-2290	DT	denotes	the
T1491	2294-2298	NN	denotes	type
T1492	2291-2293	NN	denotes	KH
T1493	2303-2308	JJ	denotes	known
T1494	2309-2319	NNS	denotes	regulators
T1495	2320-2322	IN	denotes	of
T1496	2323-2331	JJ	denotes	cellular
T1497	2332-2347	NN	denotes	differentiation
T1498	2347-2348	.	denotes	.
T1499	2348-2538	sentence	denotes	For example, expression defects in the KH domain proteins NOVA and FMRP are known to cause paraneoplastic neurologic disorders [31] and the fragile X syndrome, respectively, in humans [32].
T1500	2349-2352	IN	denotes	For
T1501	2425-2430	VBN	denotes	known
T1502	2353-2360	NN	denotes	example
T1503	2360-2362	,	denotes	,
T1504	2362-2372	NN	denotes	expression
T1505	2373-2380	NNS	denotes	defects
T1506	2381-2383	IN	denotes	in
T1507	2384-2387	DT	denotes	the
T1508	2398-2406	NN	denotes	proteins
T1509	2388-2390	NN	denotes	KH
T1510	2391-2397	NN	denotes	domain
T1511	2407-2411	NN	denotes	NOVA
T1512	2412-2415	CC	denotes	and
T1513	2416-2420	NN	denotes	FMRP
T1514	2421-2424	VBP	denotes	are
T1515	2431-2433	TO	denotes	to
T1516	2434-2439	VB	denotes	cause
T1517	2440-2454	JJ	denotes	paraneoplastic
T1518	2466-2475	NNS	denotes	disorders
T1519	2455-2465	JJ	denotes	neurologic
T1520	2476-2477	-LRB-	denotes	[
T1521	2477-2479	CD	denotes	31
T1522	2479-2480	-RRB-	denotes	]
T1523	2481-2484	CC	denotes	and
T1524	2485-2488	DT	denotes	the
T1525	2499-2507	NN	denotes	syndrome
T1526	2489-2496	JJ	denotes	fragile
T1527	2497-2498	NN	denotes	X
T1528	2507-2509	,	denotes	,
T1529	2509-2521	RB	denotes	respectively
T1530	2521-2523	,	denotes	,
T1531	2523-2525	IN	denotes	in
T1532	2526-2532	NNS	denotes	humans
T1533	2533-2534	-LRB-	denotes	[
T1534	2534-2536	CD	denotes	32
T1535	2536-2537	-RRB-	denotes	]
T1536	2537-2538	.	denotes	.
T1537	2538-2673	sentence	denotes	The phenotype of the quaking viable mice suggests a role for the QUAKING RNA binding protein in oligodendrocytes and myelination [33].
T1538	2539-2542	DT	denotes	The
T1539	2543-2552	NN	denotes	phenotype
T1540	2580-2588	VBZ	denotes	suggests
T1541	2553-2555	IN	denotes	of
T1542	2556-2559	DT	denotes	the
T1543	2575-2579	NNS	denotes	mice
T1544	2560-2567	NN	denotes	quaking
T1545	2568-2574	JJ	denotes	viable
T1546	2589-2590	DT	denotes	a
T1547	2591-2595	NN	denotes	role
T1548	2596-2599	IN	denotes	for
T1549	2600-2603	DT	denotes	the
T1550	2624-2631	NN	denotes	protein
T1551	2604-2611	NN	denotes	QUAKING
T1552	2612-2615	NN	denotes	RNA
T1553	2616-2623	NN	denotes	binding
T1554	2632-2634	IN	denotes	in
T1555	2635-2651	NNS	denotes	oligodendrocytes
T1556	2652-2655	CC	denotes	and
T1557	2656-2667	NN	denotes	myelination
T1558	2668-2669	-LRB-	denotes	[
T1559	2669-2671	CD	denotes	33
T1560	2671-2672	-RRB-	denotes	]
T1561	2672-2673	.	denotes	.
T1562	2673-2872	sentence	denotes	Indeed, the ectopic expression of the QKI-6/7 isoforms in vivo led to the formation of glial cells rather than neurons from neural progenitor, demonstrating its role in cell fate determination [34].
T1563	2674-2680	RB	denotes	Indeed
T1564	2737-2740	VBD	denotes	led
T1565	2680-2682	,	denotes	,
T1566	2682-2685	DT	denotes	the
T1567	2694-2704	NN	denotes	expression
T1568	2686-2693	JJ	denotes	ectopic
T1569	2705-2707	IN	denotes	of
T1570	2708-2711	DT	denotes	the
T1571	2720-2728	NNS	denotes	isoforms
T1572	2712-2715	NN	denotes	QKI
T1573	2718-2719	CD	denotes	7
T1574	2715-2716	HYPH	denotes	-
T1575	2716-2717	CD	denotes	6
T1576	2717-2718	HYPH	denotes	/
T1577	2729-2731	FW	denotes	in
T1578	2732-2736	FW	denotes	vivo
T1579	2741-2743	IN	denotes	to
T1580	2744-2747	DT	denotes	the
T1581	2748-2757	NN	denotes	formation
T1582	2758-2760	IN	denotes	of
T1583	2761-2766	JJ	denotes	glial
T1584	2767-2772	NNS	denotes	cells
T1585	2773-2779	RB	denotes	rather
T1586	2780-2784	IN	denotes	than
T1587	2785-2792	NNS	denotes	neurons
T1588	2793-2797	IN	denotes	from
T1589	2798-2804	JJ	denotes	neural
T1590	2805-2815	NN	denotes	progenitor
T1591	2815-2817	,	denotes	,
T1592	2817-2830	VBG	denotes	demonstrating
T1593	2831-2834	PRP$	denotes	its
T1594	2835-2839	NN	denotes	role
T1595	2840-2842	IN	denotes	in
T1596	2843-2847	NN	denotes	cell
T1597	2853-2866	NN	denotes	determination
T1598	2848-2852	NN	denotes	fate
T1599	2867-2868	-LRB-	denotes	[
T1600	2868-2870	CD	denotes	34
T1601	2870-2871	-RRB-	denotes	]
T1602	2871-2872	.	denotes	.
T1603	2872-3109	sentence	denotes	The loss of GLD-1 protein in Caenorhabditis elegans prevents the appearance of stem cells [35], and the absence of the KH domain protein HOW in Drosophila prevents muscle differentiation and results in flies with held-out-wings [36,37].
T1604	2873-2876	DT	denotes	The
T1605	2877-2881	NN	denotes	loss
T1606	2925-2933	VBZ	denotes	prevents
T1607	2882-2884	IN	denotes	of
T1608	2885-2888	NN	denotes	GLD
T1609	2891-2898	NN	denotes	protein
T1610	2888-2889	HYPH	denotes	-
T1611	2889-2890	CD	denotes	1
T1612	2899-2901	IN	denotes	in
T1613	2902-2916	NNP	denotes	Caenorhabditis
T1614	2917-2924	NNP	denotes	elegans
T1615	2934-2937	DT	denotes	the
T1616	2938-2948	NN	denotes	appearance
T1617	2949-2951	IN	denotes	of
T1618	2952-2956	NN	denotes	stem
T1619	2957-2962	NNS	denotes	cells
T1620	2963-2964	-LRB-	denotes	[
T1621	2964-2966	CD	denotes	35
T1622	2966-2967	-RRB-	denotes	]
T1623	2967-2969	,	denotes	,
T1624	2969-2972	CC	denotes	and
T1625	2973-2976	DT	denotes	the
T1626	2977-2984	NN	denotes	absence
T1627	3028-3036	VBZ	denotes	prevents
T1628	2985-2987	IN	denotes	of
T1629	2988-2991	DT	denotes	the
T1630	3002-3009	NN	denotes	protein
T1631	2992-2994	NN	denotes	KH
T1632	2995-3001	NN	denotes	domain
T1633	3010-3013	NN	denotes	HOW
T1634	3014-3016	IN	denotes	in
T1635	3017-3027	NNP	denotes	Drosophila
T1636	3037-3043	NN	denotes	muscle
T1637	3044-3059	NN	denotes	differentiation
T1638	3060-3063	CC	denotes	and
T1639	3064-3071	VBZ	denotes	results
T1640	3072-3074	IN	denotes	in
T1641	3075-3080	NNS	denotes	flies
T1642	3081-3085	IN	denotes	with
T1643	3086-3090	VBN	denotes	held
T1644	3095-3100	NNS	denotes	wings
T1645	3090-3091	HYPH	denotes	-
T1646	3091-3094	RP	denotes	out
T1647	3094-3095	HYPH	denotes	-
T1648	3101-3102	-LRB-	denotes	[
T1649	3105-3107	CD	denotes	37
T1650	3102-3104	CD	denotes	36
T1651	3104-3105	,	denotes	,
T1652	3107-3108	-RRB-	denotes	]
T1653	3108-3109	.	denotes	.
T1654	3109-3292	sentence	denotes	The Src substrate associated in mitosis of 68 kDa (Sam68) is also a member of the family of KH domain RNA binding proteins [38]; however, its physiologic role has remained undefined.
T1655	3110-3113	DT	denotes	The
T1656	3118-3127	NN	denotes	substrate
T1657	3114-3117	NN	denotes	Src
T1658	3168-3170	VBZ	denotes	is
T1659	3128-3138	VBN	denotes	associated
T1660	3139-3141	IN	denotes	in
T1661	3142-3149	NN	denotes	mitosis
T1662	3150-3152	IN	denotes	of
T1663	3153-3155	CD	denotes	68
T1664	3156-3159	NN	denotes	kDa
T1665	3160-3161	-LRB-	denotes	(
T1666	3161-3166	NN	denotes	Sam68
T1667	3166-3167	-RRB-	denotes	)
T1668	3273-3281	VBN	denotes	remained
T1669	3171-3175	RB	denotes	also
T1670	3176-3177	DT	denotes	a
T1671	3178-3184	NN	denotes	member
T1672	3185-3187	IN	denotes	of
T1673	3188-3191	DT	denotes	the
T1674	3192-3198	NN	denotes	family
T1675	3199-3201	IN	denotes	of
T1676	3202-3204	NN	denotes	KH
T1677	3224-3232	NN	denotes	proteins
T1678	3205-3211	NN	denotes	domain
T1679	3212-3215	NN	denotes	RNA
T1680	3216-3223	NN	denotes	binding
T1681	3233-3234	-LRB-	denotes	[
T1682	3234-3236	CD	denotes	38
T1683	3236-3237	-RRB-	denotes	]
T1684	3237-3238	:	denotes	;
T1685	3239-3246	RB	denotes	however
T1686	3246-3248	,	denotes	,
T1687	3248-3251	PRP$	denotes	its
T1688	3264-3268	NN	denotes	role
T1689	3252-3263	JJ	denotes	physiologic
T1690	3269-3272	VBZ	denotes	has
T1691	3282-3291	JJ	denotes	undefined
T1692	3291-3292	.	denotes	.
T1693	3292-3471	sentence	denotes	Sam68 was identified as an SH3 and SH2 domain interacting protein for Src family kinases and is also a known substrate of Src kinases [39–42] and of the breast tumor kinase [43].
T1694	3293-3298	NN	denotes	Sam68
T1695	3303-3313	VBN	denotes	identified
T1696	3299-3302	VBD	denotes	was
T1697	3314-3316	IN	denotes	as
T1698	3317-3319	DT	denotes	an
T1699	3351-3358	NN	denotes	protein
T1700	3320-3323	NN	denotes	SH3
T1701	3324-3327	CC	denotes	and
T1702	3328-3331	NN	denotes	SH2
T1703	3332-3338	NN	denotes	domain
T1704	3339-3350	VBG	denotes	interacting
T1705	3359-3362	IN	denotes	for
T1706	3363-3366	NN	denotes	Src
T1707	3374-3381	NNS	denotes	kinases
T1708	3367-3373	NN	denotes	family
T1709	3382-3385	CC	denotes	and
T1710	3386-3388	VBZ	denotes	is
T1711	3389-3393	RB	denotes	also
T1712	3394-3395	DT	denotes	a
T1713	3402-3411	NN	denotes	substrate
T1714	3396-3401	JJ	denotes	known
T1715	3412-3414	IN	denotes	of
T1716	3415-3418	NN	denotes	Src
T1717	3419-3426	NNS	denotes	kinases
T1718	3427-3428	-LRB-	denotes	[
T1719	3428-3430	CD	denotes	39
T1720	3430-3431	SYM	denotes	–
T1721	3431-3433	CD	denotes	42
T1722	3433-3434	-RRB-	denotes	]
T1723	3435-3438	CC	denotes	and
T1724	3439-3441	IN	denotes	of
T1725	3442-3445	DT	denotes	the
T1726	3459-3465	NN	denotes	kinase
T1727	3446-3452	NN	denotes	breast
T1728	3453-3458	NN	denotes	tumor
T1729	3466-3467	-LRB-	denotes	[
T1730	3467-3469	CD	denotes	43
T1731	3469-3470	-RRB-	denotes	]
T1732	3470-3471	.	denotes	.
T1733	3471-3585	sentence	denotes	Sam68 has been shown to facilitate the export of unspliced HIV RNA [44] and to regulate pre-mRNA processing [45].
T1734	3472-3477	NN	denotes	Sam68
T1735	3487-3492	VBN	denotes	shown
T1736	3478-3481	VBZ	denotes	has
T1737	3482-3486	VBN	denotes	been
T1738	3493-3495	TO	denotes	to
T1739	3496-3506	VB	denotes	facilitate
T1740	3507-3510	DT	denotes	the
T1741	3511-3517	NN	denotes	export
T1742	3518-3520	IN	denotes	of
T1743	3521-3530	JJ	denotes	unspliced
T1744	3535-3538	NN	denotes	RNA
T1745	3531-3534	NN	denotes	HIV
T1746	3539-3540	-LRB-	denotes	[
T1747	3540-3542	CD	denotes	44
T1748	3542-3543	-RRB-	denotes	]
T1749	3544-3547	CC	denotes	and
T1750	3548-3550	TO	denotes	to
T1751	3551-3559	VB	denotes	regulate
T1752	3560-3568	NN	denotes	pre-mRNA
T1753	3569-3579	NN	denotes	processing
T1754	3580-3581	-LRB-	denotes	[
T1755	3581-3583	CD	denotes	45
T1756	3583-3584	-RRB-	denotes	]
T1757	3584-3585	.	denotes	.
T1758	3585-3691	sentence	denotes	In the present paper, we report the generation of Sam68−/− mice and analysis of their skeletal phenotype.
T1759	3586-3588	IN	denotes	In
T1760	3611-3617	VBP	denotes	report
T1761	3589-3592	DT	denotes	the
T1762	3601-3606	NN	denotes	paper
T1763	3593-3600	JJ	denotes	present
T1764	3606-3608	,	denotes	,
T1765	3608-3610	PRP	denotes	we
T1766	3618-3621	DT	denotes	the
T1767	3622-3632	NN	denotes	generation
T1768	3633-3635	IN	denotes	of
T1769	3636-3641	NN	denotes	Sam68
T1770	3645-3649	NNS	denotes	mice
T1771	3641-3642	SYM	denotes	−
T1772	3642-3643	HYPH	denotes	/
T1773	3643-3644	SYM	denotes	−
T1774	3650-3653	CC	denotes	and
T1775	3654-3662	NN	denotes	analysis
T1776	3663-3665	IN	denotes	of
T1777	3666-3671	PRP$	denotes	their
T1778	3681-3690	NN	denotes	phenotype
T1779	3672-3680	JJ	denotes	skeletal
T1780	3690-3691	.	denotes	.
T1781	3691-3865	sentence	denotes	Our data indicate that the absence of Sam68 confers resistance to age-related bone loss in mice such that old Sam68 have a higher bone mass than their wild-type littermates.
T1782	3692-3695	PRP$	denotes	Our
T1783	3696-3700	NNS	denotes	data
T1784	3701-3709	VBP	denotes	indicate
T1785	3710-3714	IN	denotes	that
T1786	3736-3743	VBZ	denotes	confers
T1787	3715-3718	DT	denotes	the
T1788	3719-3726	NN	denotes	absence
T1789	3727-3729	IN	denotes	of
T1790	3730-3735	NN	denotes	Sam68
T1791	3744-3754	NN	denotes	resistance
T1792	3755-3757	IN	denotes	to
T1793	3758-3761	NN	denotes	age
T1794	3762-3769	VBN	denotes	related
T1795	3761-3762	HYPH	denotes	-
T1796	3775-3779	NN	denotes	loss
T1797	3770-3774	NN	denotes	bone
T1798	3780-3782	IN	denotes	in
T1799	3783-3787	NNS	denotes	mice
T1800	3788-3792	JJ	denotes	such
T1801	3808-3812	VBP	denotes	have
T1802	3793-3797	IN	denotes	that
T1803	3798-3801	JJ	denotes	old
T1804	3802-3807	NN	denotes	Sam68
T1805	3813-3814	DT	denotes	a
T1806	3827-3831	NN	denotes	mass
T1807	3815-3821	JJR	denotes	higher
T1808	3822-3826	NN	denotes	bone
T1809	3832-3836	IN	denotes	than
T1810	3837-3842	PRP$	denotes	their
T1811	3853-3864	NNS	denotes	littermates
T1812	3843-3847	JJ	denotes	wild
T1813	3848-3852	NN	denotes	type
T1814	3847-3848	HYPH	denotes	-
T1815	3864-3865	.	denotes	.
T1816	3865-4124	sentence	denotes	We provide evidence that Sam68 regulates the differentiation of bone marrow stromal cells by showing that cells isolated from Sam68−/− animals had enhanced osteogenic activity and decreased adipogenic activity than those harvested from wild-type littermates.
T1817	3866-3868	PRP	denotes	We
T1818	3869-3876	VBP	denotes	provide
T1819	3877-3885	NN	denotes	evidence
T1820	3886-3890	IN	denotes	that
T1821	3897-3906	VBZ	denotes	regulates
T1822	3891-3896	NN	denotes	Sam68
T1823	3907-3910	DT	denotes	the
T1824	3911-3926	NN	denotes	differentiation
T1825	3927-3929	IN	denotes	of
T1826	3930-3934	NN	denotes	bone
T1827	3935-3941	NN	denotes	marrow
T1828	3950-3955	NNS	denotes	cells
T1829	3942-3949	JJ	denotes	stromal
T1830	3956-3958	IN	denotes	by
T1831	3959-3966	VBG	denotes	showing
T1832	3967-3971	IN	denotes	that
T1833	4009-4012	VBD	denotes	had
T1834	3972-3977	NNS	denotes	cells
T1835	3978-3986	VBN	denotes	isolated
T1836	3987-3991	IN	denotes	from
T1837	3992-3997	NN	denotes	Sam68
T1838	4001-4008	NNS	denotes	animals
T1839	3997-3998	SYM	denotes	−
T1840	3998-3999	HYPH	denotes	/
T1841	3999-4000	SYM	denotes	−
T1842	4013-4021	VBN	denotes	enhanced
T1843	4033-4041	NN	denotes	activity
T1844	4022-4032	JJ	denotes	osteogenic
T1845	4042-4045	CC	denotes	and
T1846	4046-4055	VBN	denotes	decreased
T1847	4067-4075	NN	denotes	activity
T1848	4056-4066	JJ	denotes	adipogenic
T1849	4076-4080	IN	denotes	than
T1850	4081-4086	DT	denotes	those
T1851	4087-4096	VBN	denotes	harvested
T1852	4097-4101	IN	denotes	from
T1853	4102-4106	JJ	denotes	wild
T1854	4107-4111	NN	denotes	type
T1855	4106-4107	HYPH	denotes	-
T1856	4112-4123	NNS	denotes	littermates
T1857	4123-4124	.	denotes	.
T1858	4124-4333	sentence	denotes	Furthermore, Sam68−/− mouse embryo fibroblasts (MEFs) were impaired in their capacity to differentiate into adipocytes, consistent with Sam68 being a regulator of bone marrow mesenchymal cell differentiation.
T1859	4125-4136	RB	denotes	Furthermore
T1860	4184-4192	VBN	denotes	impaired
T1861	4136-4138	,	denotes	,
T1862	4138-4143	NN	denotes	Sam68
T1863	4143-4144	SYM	denotes	−
T1864	4144-4145	HYPH	denotes	/
T1865	4145-4146	SYM	denotes	−
T1866	4147-4152	NN	denotes	mouse
T1867	4153-4159	NN	denotes	embryo
T1868	4160-4171	NNS	denotes	fibroblasts
T1869	4172-4173	-LRB-	denotes	(
T1870	4173-4177	NNS	denotes	MEFs
T1871	4177-4178	-RRB-	denotes	)
T1872	4179-4183	VBD	denotes	were
T1873	4193-4195	IN	denotes	in
T1874	4196-4201	PRP$	denotes	their
T1875	4202-4210	NN	denotes	capacity
T1876	4211-4213	TO	denotes	to
T1877	4214-4227	VB	denotes	differentiate
T1878	4228-4232	IN	denotes	into
T1879	4233-4243	NNS	denotes	adipocytes
T1880	4243-4245	,	denotes	,
T1881	4245-4255	JJ	denotes	consistent
T1882	4256-4260	IN	denotes	with
T1883	4261-4266	NN	denotes	Sam68
T1884	4267-4272	VBG	denotes	being
T1885	4273-4274	DT	denotes	a
T1886	4275-4284	NN	denotes	regulator
T1887	4285-4287	IN	denotes	of
T1888	4288-4292	NN	denotes	bone
T1889	4293-4299	NN	denotes	marrow
T1890	4317-4332	NN	denotes	differentiation
T1891	4300-4311	JJ	denotes	mesenchymal
T1892	4312-4316	NN	denotes	cell
T1893	4332-4333	.	denotes	.
T1894	4333-4449	sentence	denotes	These results also characterize a new animal model to study bone metabolism, regeneration, and repair during aging.
T1895	4334-4339	DT	denotes	These
T1896	4340-4347	NNS	denotes	results
T1897	4353-4365	VBP	denotes	characterize
T1898	4348-4352	RB	denotes	also
T1899	4366-4367	DT	denotes	a
T1900	4379-4384	NN	denotes	model
T1901	4368-4371	JJ	denotes	new
T1902	4372-4378	NN	denotes	animal
T1903	4385-4387	TO	denotes	to
T1904	4388-4393	VB	denotes	study
T1905	4394-4398	NN	denotes	bone
T1906	4399-4409	NN	denotes	metabolism
T1907	4409-4411	,	denotes	,
T1908	4411-4423	NN	denotes	regeneration
T1909	4423-4425	,	denotes	,
T1910	4425-4428	CC	denotes	and
T1911	4429-4435	NN	denotes	repair
T1912	4436-4442	IN	denotes	during
T1913	4443-4448	NN	denotes	aging
T1914	4448-4449	.	denotes	.
T2061	4460-4465	NN	denotes	Sam68
T2062	4469-4478	VBN	denotes	Expressed
T2063	4466-4468	VBZ	denotes	Is
T2064	4479-4481	IN	denotes	in
T2065	4482-4485	DT	denotes	the
T2066	4497-4505	NN	denotes	Skeleton
T2067	4486-4496	VBG	denotes	Developing
T2068	4506-4508	IN	denotes	of
T2069	4509-4518	JJ	denotes	Embryonic
T2070	4519-4523	NNS	denotes	Mice
T2071	4523-4649	sentence	denotes	The Sam68 mRNA is known to be widely expressed [38], whereas its pattern of protein expression in vivo remains to be defined.
T2072	4524-4527	DT	denotes	The
T2073	4534-4538	NN	denotes	mRNA
T2074	4528-4533	NN	denotes	Sam68
T2075	4542-4547	VBN	denotes	known
T2076	4539-4541	VBZ	denotes	is
T2077	4548-4550	TO	denotes	to
T2078	4561-4570	VBN	denotes	expressed
T2079	4551-4553	VB	denotes	be
T2080	4554-4560	RB	denotes	widely
T2081	4571-4572	-LRB-	denotes	[
T2082	4572-4574	CD	denotes	38
T2083	4574-4575	-RRB-	denotes	]
T2084	4575-4577	,	denotes	,
T2085	4577-4584	IN	denotes	whereas
T2086	4627-4634	VBZ	denotes	remains
T2087	4585-4588	PRP$	denotes	its
T2088	4589-4596	NN	denotes	pattern
T2089	4597-4599	IN	denotes	of
T2090	4600-4607	NN	denotes	protein
T2091	4608-4618	NN	denotes	expression
T2092	4619-4621	FW	denotes	in
T2093	4622-4626	FW	denotes	vivo
T2094	4635-4637	TO	denotes	to
T2095	4641-4648	VBN	denotes	defined
T2096	4638-4640	VB	denotes	be
T2097	4648-4649	.	denotes	.
T2098	4649-4916	sentence	denotes	Sections of paraffin-embedded wild-type E14.5 and E16.5 embryonic mice were immunostained with the well-characterized AD1 anti-Sam68 antibody, raised in rabbits against an immunizing peptide that corresponds to amino acids 330 to 348 of the mouse Sam68 protein [46].
T2099	4650-4658	NNS	denotes	Sections
T2100	4726-4739	VBN	denotes	immunostained
T2101	4659-4661	IN	denotes	of
T2102	4662-4670	NN	denotes	paraffin
T2103	4671-4679	VBN	denotes	embedded
T2104	4670-4671	HYPH	denotes	-
T2105	4716-4720	NNS	denotes	mice
T2106	4680-4684	JJ	denotes	wild
T2107	4685-4689	NN	denotes	type
T2108	4684-4685	HYPH	denotes	-
T2109	4690-4695	NN	denotes	E14.5
T2110	4696-4699	CC	denotes	and
T2111	4700-4705	NN	denotes	E16.5
T2112	4706-4715	JJ	denotes	embryonic
T2113	4721-4725	VBD	denotes	were
T2114	4740-4744	IN	denotes	with
T2115	4745-4748	DT	denotes	the
T2116	4783-4791	NN	denotes	antibody
T2117	4749-4753	RB	denotes	well
T2118	4754-4767	VBN	denotes	characterized
T2119	4753-4754	HYPH	denotes	-
T2120	4768-4771	NN	denotes	AD1
T2121	4772-4782	JJ	denotes	anti-Sam68
T2122	4791-4793	,	denotes	,
T2123	4793-4799	VBN	denotes	raised
T2124	4800-4802	IN	denotes	in
T2125	4803-4810	NNS	denotes	rabbits
T2126	4811-4818	IN	denotes	against
T2127	4819-4821	DT	denotes	an
T2128	4833-4840	NN	denotes	peptide
T2129	4822-4832	VBG	denotes	immunizing
T2130	4841-4845	WDT	denotes	that
T2131	4846-4857	VBZ	denotes	corresponds
T2132	4858-4860	IN	denotes	to
T2133	4861-4866	NN	denotes	amino
T2134	4873-4876	CD	denotes	330
T2135	4867-4872	NNS	denotes	acids
T2136	4877-4879	IN	denotes	to
T2137	4880-4883	CD	denotes	348
T2138	4884-4886	IN	denotes	of
T2139	4887-4890	DT	denotes	the
T2140	4903-4910	NN	denotes	protein
T2141	4891-4896	NN	denotes	mouse
T2142	4897-4902	NN	denotes	Sam68
T2143	4911-4912	-LRB-	denotes	[
T2144	4912-4914	CD	denotes	46
T2145	4914-4915	-RRB-	denotes	]
T2146	4915-4916	.	denotes	.
T2147	4916-5045	sentence	denotes	Sam68 immunoreactivity was observed in the skeleton and soft tissues of developing wild-type mice at E14.5 and E16.5 (Figure 1).
T2148	4917-4922	NN	denotes	Sam68
T2149	4923-4939	NN	denotes	immunoreactivity
T2150	4944-4952	VBN	denotes	observed
T2151	4940-4943	VBD	denotes	was
T2152	4953-4955	IN	denotes	in
T2153	4956-4959	DT	denotes	the
T2154	4960-4968	NN	denotes	skeleton
T2155	4969-4972	CC	denotes	and
T2156	4973-4977	JJ	denotes	soft
T2157	4978-4985	NNS	denotes	tissues
T2158	4986-4988	IN	denotes	of
T2159	4989-4999	VBG	denotes	developing
T2160	5010-5014	NNS	denotes	mice
T2161	5000-5004	JJ	denotes	wild
T2162	5005-5009	NN	denotes	type
T2163	5004-5005	HYPH	denotes	-
T2164	5015-5017	IN	denotes	at
T2165	5018-5023	NN	denotes	E14.5
T2166	5024-5027	CC	denotes	and
T2167	5028-5033	NN	denotes	E16.5
T2168	5034-5035	-LRB-	denotes	(
T2169	5035-5041	NN	denotes	Figure
T2170	5042-5043	CD	denotes	1
T2171	5043-5044	-RRB-	denotes	)
T2172	5044-5045	.	denotes	.
T2173	5045-5417	sentence	denotes	Intense staining was seen in the nucleus of cells in the developing brain, heart, and small intestine (Figure 1B), as well as in chondrocytes in the nasal septum and the glandular tissue adjacent to the nasal cartilage (Figure 1C, panels A–D), in the vertebra and intervertebral discs (panels E–H) and in the epiphysis (panels I–K) and metaphysis (panel L) of long bones.
T2174	5046-5053	JJ	denotes	Intense
T2175	5054-5062	NN	denotes	staining
T2176	5067-5071	VBN	denotes	seen
T2177	5063-5066	VBD	denotes	was
T2178	5072-5074	IN	denotes	in
T2179	5075-5078	DT	denotes	the
T2180	5079-5086	NN	denotes	nucleus
T2181	5087-5089	IN	denotes	of
T2182	5090-5095	NNS	denotes	cells
T2183	5096-5098	IN	denotes	in
T2184	5099-5102	DT	denotes	the
T2185	5114-5119	NN	denotes	brain
T2186	5103-5113	VBG	denotes	developing
T2187	5119-5121	,	denotes	,
T2188	5121-5126	NN	denotes	heart
T2189	5126-5128	,	denotes	,
T2190	5128-5131	CC	denotes	and
T2191	5132-5137	JJ	denotes	small
T2192	5138-5147	NN	denotes	intestine
T2193	5148-5149	-LRB-	denotes	(
T2194	5156-5158	NN	denotes	1B
T2195	5149-5155	NN	denotes	Figure
T2196	5158-5159	-RRB-	denotes	)
T2197	5159-5161	,	denotes	,
T2198	5161-5163	RB	denotes	as
T2199	5169-5171	IN	denotes	as
T2200	5164-5168	RB	denotes	well
T2201	5172-5174	IN	denotes	in
T2202	5175-5187	NNS	denotes	chondrocytes
T2203	5188-5190	IN	denotes	in
T2204	5191-5194	DT	denotes	the
T2205	5201-5207	NN	denotes	septum
T2206	5195-5200	JJ	denotes	nasal
T2207	5208-5211	CC	denotes	and
T2208	5212-5215	DT	denotes	the
T2209	5226-5232	NN	denotes	tissue
T2210	5216-5225	JJ	denotes	glandular
T2211	5233-5241	JJ	denotes	adjacent
T2212	5242-5244	IN	denotes	to
T2213	5245-5248	DT	denotes	the
T2214	5255-5264	NN	denotes	cartilage
T2215	5249-5254	JJ	denotes	nasal
T2216	5265-5266	-LRB-	denotes	(
T2217	5273-5275	NN	denotes	1C
T2218	5266-5272	NN	denotes	Figure
T2219	5275-5277	,	denotes	,
T2220	5277-5283	NNS	denotes	panels
T2221	5284-5285	NN	denotes	A
T2222	5285-5286	SYM	denotes	–
T2223	5286-5287	NN	denotes	D
T2224	5287-5288	-RRB-	denotes	)
T2225	5288-5290	,	denotes	,
T2226	5290-5292	IN	denotes	in
T2227	5293-5296	DT	denotes	the
T2228	5297-5305	NNS	denotes	vertebra
T2229	5306-5309	CC	denotes	and
T2230	5310-5324	JJ	denotes	intervertebral
T2231	5325-5330	NNS	denotes	discs
T2232	5331-5332	-LRB-	denotes	(
T2233	5339-5340	NN	denotes	E
T2234	5332-5338	NNS	denotes	panels
T2235	5340-5341	SYM	denotes	–
T2236	5341-5342	NN	denotes	H
T2237	5342-5343	-RRB-	denotes	)
T2238	5344-5347	CC	denotes	and
T2239	5348-5350	IN	denotes	in
T2240	5351-5354	DT	denotes	the
T2241	5355-5364	NN	denotes	epiphysis
T2242	5365-5366	-LRB-	denotes	(
T2243	5373-5374	NN	denotes	I
T2244	5366-5372	NNS	denotes	panels
T2245	5374-5375	SYM	denotes	–
T2246	5375-5376	NN	denotes	K
T2247	5376-5377	-RRB-	denotes	)
T2248	5378-5381	CC	denotes	and
T2249	5382-5392	NN	denotes	metaphysis
T2250	5393-5394	-LRB-	denotes	(
T2251	5400-5401	NN	denotes	L
T2252	5394-5399	NN	denotes	panel
T2253	5401-5402	-RRB-	denotes	)
T2254	5403-5405	IN	denotes	of
T2255	5406-5410	JJ	denotes	long
T2256	5411-5416	NNS	denotes	bones
T2257	5416-5417	.	denotes	.
T2258	5417-5600	sentence	denotes	Nuclear staining was observed in proliferating chondrocytes and hypertrophic chondrocytes (Figure 1C, panel H), in osteoblasts (panel L; Dataset S1), and in osteoclasts (Dataset S1).
T2259	5418-5425	JJ	denotes	Nuclear
T2260	5426-5434	NN	denotes	staining
T2261	5439-5447	VBN	denotes	observed
T2262	5435-5438	VBD	denotes	was
T2263	5448-5450	IN	denotes	in
T2264	5451-5464	VBG	denotes	proliferating
T2265	5465-5477	NNS	denotes	chondrocytes
T2266	5478-5481	CC	denotes	and
T2267	5482-5494	JJ	denotes	hypertrophic
T2268	5495-5507	NNS	denotes	chondrocytes
T2269	5508-5509	-LRB-	denotes	(
T2270	5516-5518	NN	denotes	1C
T2271	5509-5515	NN	denotes	Figure
T2272	5518-5520	,	denotes	,
T2273	5520-5525	NN	denotes	panel
T2274	5526-5527	NN	denotes	H
T2275	5527-5528	-RRB-	denotes	)
T2276	5528-5530	,	denotes	,
T2277	5530-5532	IN	denotes	in
T2278	5533-5544	NNS	denotes	osteoblasts
T2279	5545-5546	-LRB-	denotes	(
T2280	5552-5553	NN	denotes	L
T2281	5546-5551	NN	denotes	panel
T2282	5553-5554	:	denotes	;
T2283	5555-5562	NN	denotes	Dataset
T2284	5563-5565	NN	denotes	S1
T2285	5565-5566	-RRB-	denotes	)
T2286	5566-5568	,	denotes	,
T2287	5568-5571	CC	denotes	and
T2288	5572-5574	IN	denotes	in
T2289	5575-5586	NNS	denotes	osteoclasts
T2290	5587-5588	-LRB-	denotes	(
T2291	5596-5598	NN	denotes	S1
T2292	5588-5595	NN	denotes	Dataset
T2293	5598-5599	-RRB-	denotes	)
T2294	5599-5600	.	denotes	.
T2295	5600-5745	sentence	denotes	No staining was observed with preimmune serum or when the antiserum was preadsorbed with the immunizing peptide (Figure 1C, panels B, F, and J).
T2296	5601-5603	DT	denotes	No
T2297	5604-5612	NN	denotes	staining
T2298	5617-5625	VBN	denotes	observed
T2299	5613-5616	VBD	denotes	was
T2300	5626-5630	IN	denotes	with
T2301	5631-5640	JJ	denotes	preimmune
T2302	5641-5646	NN	denotes	serum
T2303	5647-5649	CC	denotes	or
T2304	5650-5654	WRB	denotes	when
T2305	5673-5684	VBN	denotes	preadsorbed
T2306	5655-5658	DT	denotes	the
T2307	5659-5668	NN	denotes	antiserum
T2308	5669-5672	VBD	denotes	was
T2309	5685-5689	IN	denotes	with
T2310	5690-5693	DT	denotes	the
T2311	5705-5712	NN	denotes	peptide
T2312	5694-5704	VBG	denotes	immunizing
T2313	5713-5714	-LRB-	denotes	(
T2314	5721-5723	NN	denotes	1C
T2315	5714-5720	NN	denotes	Figure
T2316	5723-5725	,	denotes	,
T2317	5725-5731	NNS	denotes	panels
T2318	5732-5733	NN	denotes	B
T2319	5733-5735	,	denotes	,
T2320	5735-5736	NN	denotes	F
T2321	5736-5738	,	denotes	,
T2322	5738-5741	CC	denotes	and
T2323	5742-5743	NN	denotes	J
T2324	5743-5744	-RRB-	denotes	)
T2325	5744-5745	.	denotes	.
T2326	5745-5921	sentence	denotes	Taken together, these data demonstrate that Sam68 protein is selectively expressed in the developing mouse embryo, with particularly elevated expression in cartilage and bone.
T2327	5746-5751	VBN	denotes	Taken
T2328	5773-5784	VBP	denotes	demonstrate
T2329	5752-5760	RB	denotes	together
T2330	5760-5762	,	denotes	,
T2331	5762-5767	DT	denotes	these
T2332	5768-5772	NNS	denotes	data
T2333	5785-5789	IN	denotes	that
T2334	5819-5828	VBN	denotes	expressed
T2335	5790-5795	NN	denotes	Sam68
T2336	5796-5803	NN	denotes	protein
T2337	5804-5806	VBZ	denotes	is
T2338	5807-5818	RB	denotes	selectively
T2339	5829-5831	IN	denotes	in
T2340	5832-5835	DT	denotes	the
T2341	5853-5859	NN	denotes	embryo
T2342	5836-5846	VBG	denotes	developing
T2343	5847-5852	NN	denotes	mouse
T2344	5859-5861	,	denotes	,
T2345	5861-5865	IN	denotes	with
T2346	5866-5878	RB	denotes	particularly
T2347	5879-5887	VBN	denotes	elevated
T2348	5888-5898	NN	denotes	expression
T2349	5899-5901	IN	denotes	in
T2350	5902-5911	NN	denotes	cartilage
T2351	5912-5915	CC	denotes	and
T2352	5916-5920	NN	denotes	bone
T2353	5920-5921	.	denotes	.
T2520	7122-7127	NN	denotes	Sam68
T2521	7128-7130	VBZ	denotes	is
T2522	7131-7134	RB	denotes	Not
T2523	7135-7144	JJ	denotes	Essential
T2524	7145-7148	IN	denotes	for
T2525	7149-7154	NN	denotes	Mouse
T2526	7155-7166	NN	denotes	Development
T2527	7166-7382	sentence	denotes	To define the physiologic role of Sam68, we generated Sam68-deficient mice by targeted disruption of exons 4 and 5 of the sam68 gene, which encode the functional region of the KH-type RNA binding domain (Figure 2A).
T2528	7167-7169	TO	denotes	To
T2529	7170-7176	VB	denotes	define
T2530	7211-7220	VBD	denotes	generated
T2531	7177-7180	DT	denotes	the
T2532	7193-7197	NN	denotes	role
T2533	7181-7192	JJ	denotes	physiologic
T2534	7198-7200	IN	denotes	of
T2535	7201-7206	NN	denotes	Sam68
T2536	7206-7208	,	denotes	,
T2537	7208-7210	PRP	denotes	we
T2538	7221-7226	NN	denotes	Sam68
T2539	7227-7236	JJ	denotes	deficient
T2540	7226-7227	HYPH	denotes	-
T2541	7237-7241	NNS	denotes	mice
T2542	7242-7244	IN	denotes	by
T2543	7245-7253	VBN	denotes	targeted
T2544	7254-7264	NN	denotes	disruption
T2545	7265-7267	IN	denotes	of
T2546	7268-7273	NNS	denotes	exons
T2547	7274-7275	CD	denotes	4
T2548	7276-7279	CC	denotes	and
T2549	7280-7281	CD	denotes	5
T2550	7282-7284	IN	denotes	of
T2551	7285-7288	DT	denotes	the
T2552	7295-7299	NN	denotes	gene
T2553	7289-7294	NN	denotes	sam68
T2554	7299-7301	,	denotes	,
T2555	7301-7306	WDT	denotes	which
T2556	7307-7313	VBP	denotes	encode
T2557	7314-7317	DT	denotes	the
T2558	7329-7335	NN	denotes	region
T2559	7318-7328	JJ	denotes	functional
T2560	7336-7338	IN	denotes	of
T2561	7339-7342	DT	denotes	the
T2562	7363-7369	NN	denotes	domain
T2563	7343-7345	NN	denotes	KH
T2564	7346-7350	NN	denotes	type
T2565	7345-7346	HYPH	denotes	-
T2566	7351-7354	NN	denotes	RNA
T2567	7355-7362	NN	denotes	binding
T2568	7370-7371	-LRB-	denotes	(
T2569	7378-7380	NN	denotes	2A
T2570	7371-7377	NN	denotes	Figure
T2571	7380-7381	-RRB-	denotes	)
T2572	7381-7382	.	denotes	.
T2573	7382-7516	sentence	denotes	The integrity of the targeted allele was verified by Southern blot analysis (Figure 2B) and by PCR of genomic DNA (unpublished data).
T2574	7383-7386	DT	denotes	The
T2575	7387-7396	NN	denotes	integrity
T2576	7424-7432	VBN	denotes	verified
T2577	7397-7399	IN	denotes	of
T2578	7400-7403	DT	denotes	the
T2579	7413-7419	NN	denotes	allele
T2580	7404-7412	VBN	denotes	targeted
T2581	7420-7423	VBD	denotes	was
T2582	7433-7435	IN	denotes	by
T2583	7436-7444	NNP	denotes	Southern
T2584	7445-7449	NN	denotes	blot
T2585	7450-7458	NN	denotes	analysis
T2586	7459-7460	-LRB-	denotes	(
T2587	7467-7469	NN	denotes	2B
T2588	7460-7466	NN	denotes	Figure
T2589	7469-7470	-RRB-	denotes	)
T2590	7471-7474	CC	denotes	and
T2591	7475-7477	IN	denotes	by
T2592	7478-7481	NN	denotes	PCR
T2593	7482-7484	IN	denotes	of
T2594	7485-7492	JJ	denotes	genomic
T2595	7493-7496	NN	denotes	DNA
T2596	7497-7498	-LRB-	denotes	(
T2597	7510-7514	NNS	denotes	data
T2598	7498-7509	JJ	denotes	unpublished
T2599	7514-7515	-RRB-	denotes	)
T2600	7515-7516	.	denotes	.
T2601	7516-7816	sentence	denotes	Sam68 transcripts encoded by exons 1 to 5 were absent as evidenced by RT-PCR (Dataset S2), and Sam68−/− mice were devoid of Sam68 protein, as visualized by immunoblotting with anti-Sam68 AD1 and SC-333 antibodies or control normal rabbit serum or anti-Sam68 AD1 preabsorbed with peptide (Figure 2C).
T2602	7517-7522	NN	denotes	Sam68
T2603	7523-7534	NNS	denotes	transcripts
T2604	7559-7563	VBD	denotes	were
T2605	7535-7542	VBN	denotes	encoded
T2606	7543-7545	IN	denotes	by
T2607	7546-7551	NNS	denotes	exons
T2608	7552-7553	CD	denotes	1
T2609	7554-7556	IN	denotes	to
T2610	7557-7558	CD	denotes	5
T2611	7564-7570	JJ	denotes	absent
T2612	7571-7573	IN	denotes	as
T2613	7574-7583	VBN	denotes	evidenced
T2614	7584-7586	IN	denotes	by
T2615	7587-7589	NN	denotes	RT
T2616	7590-7593	NN	denotes	PCR
T2617	7589-7590	HYPH	denotes	-
T2618	7594-7595	-LRB-	denotes	(
T2619	7603-7605	NN	denotes	S2
T2620	7595-7602	NN	denotes	Dataset
T2621	7605-7606	-RRB-	denotes	)
T2622	7606-7608	,	denotes	,
T2623	7608-7611	CC	denotes	and
T2624	7612-7617	NN	denotes	Sam68
T2625	7621-7625	NNS	denotes	mice
T2626	7617-7618	SYM	denotes	−
T2627	7618-7619	HYPH	denotes	/
T2628	7619-7620	SYM	denotes	−
T2629	7626-7630	VBD	denotes	were
T2630	7631-7637	JJ	denotes	devoid
T2631	7638-7640	IN	denotes	of
T2632	7641-7646	NN	denotes	Sam68
T2633	7647-7654	NN	denotes	protein
T2634	7654-7656	,	denotes	,
T2635	7656-7658	IN	denotes	as
T2636	7659-7669	VBN	denotes	visualized
T2637	7670-7672	IN	denotes	by
T2638	7673-7687	VBG	denotes	immunoblotting
T2639	7688-7692	IN	denotes	with
T2640	7693-7703	JJ	denotes	anti-Sam68
T2641	7704-7707	NN	denotes	AD1
T2642	7719-7729	NNS	denotes	antibodies
T2643	7708-7711	CC	denotes	and
T2644	7712-7714	NN	denotes	SC
T2645	7714-7715	HYPH	denotes	-
T2646	7715-7718	CD	denotes	333
T2647	7730-7732	CC	denotes	or
T2648	7733-7740	NN	denotes	control
T2649	7755-7760	NN	denotes	serum
T2650	7741-7747	JJ	denotes	normal
T2651	7748-7754	NN	denotes	rabbit
T2652	7761-7763	CC	denotes	or
T2653	7764-7774	JJ	denotes	anti-Sam68
T2654	7775-7778	NN	denotes	AD1
T2655	7779-7790	VBN	denotes	preabsorbed
T2656	7791-7795	IN	denotes	with
T2657	7796-7803	NN	denotes	peptide
T2658	7804-7805	-LRB-	denotes	(
T2659	7812-7814	NN	denotes	2C
T2660	7805-7811	NN	denotes	Figure
T2661	7814-7815	-RRB-	denotes	)
T2662	7815-7816	.	denotes	.
T2663	7816-7924	sentence	denotes	SC-333 is a rabbit anti-Sam68 antibody that was raised against the C-terminal 20 amino acids of Sam68 [47].
T2664	7817-7819	NN	denotes	SC
T2665	7824-7826	VBZ	denotes	is
T2666	7819-7820	HYPH	denotes	-
T2667	7820-7823	CD	denotes	333
T2668	7827-7828	DT	denotes	a
T2669	7847-7855	NN	denotes	antibody
T2670	7829-7835	NN	denotes	rabbit
T2671	7836-7846	JJ	denotes	anti-Sam68
T2672	7856-7860	WDT	denotes	that
T2673	7865-7871	VBN	denotes	raised
T2674	7861-7864	VBD	denotes	was
T2675	7872-7879	IN	denotes	against
T2676	7880-7883	DT	denotes	the
T2677	7904-7909	NNS	denotes	acids
T2678	7884-7885	NN	denotes	C
T2679	7886-7894	JJ	denotes	terminal
T2680	7885-7886	HYPH	denotes	-
T2681	7895-7897	CD	denotes	20
T2682	7898-7903	NN	denotes	amino
T2683	7910-7912	IN	denotes	of
T2684	7913-7918	NN	denotes	Sam68
T2685	7919-7920	-LRB-	denotes	[
T2686	7920-7922	CD	denotes	47
T2687	7922-7923	-RRB-	denotes	]
T2688	7923-7924	.	denotes	.
T2689	7924-7991	sentence	denotes	These data confirmed the generation of a mouse deficient in Sam68.
T2690	7925-7930	DT	denotes	These
T2691	7931-7935	NNS	denotes	data
T2692	7936-7945	VBD	denotes	confirmed
T2693	7946-7949	DT	denotes	the
T2694	7950-7960	NN	denotes	generation
T2695	7961-7963	IN	denotes	of
T2696	7964-7965	DT	denotes	a
T2697	7966-7971	NN	denotes	mouse
T2698	7972-7981	JJ	denotes	deficient
T2699	7982-7984	IN	denotes	in
T2700	7985-7990	NN	denotes	Sam68
T2701	7990-7991	.	denotes	.
T2702	7991-8103	sentence	denotes	The genotypes of offspring from heterozygote intercrosses exhibited a Mendelian segregation at E18.5 (Table 1).
T2703	7992-7995	DT	denotes	The
T2704	7996-8005	NNS	denotes	genotypes
T2705	8050-8059	VBD	denotes	exhibited
T2706	8006-8008	IN	denotes	of
T2707	8009-8018	NN	denotes	offspring
T2708	8019-8023	IN	denotes	from
T2709	8024-8036	NN	denotes	heterozygote
T2710	8037-8049	NNS	denotes	intercrosses
T2711	8060-8061	DT	denotes	a
T2712	8072-8083	NN	denotes	segregation
T2713	8062-8071	JJ	denotes	Mendelian
T2714	8084-8086	IN	denotes	at
T2715	8087-8092	NN	denotes	E18.5
T2716	8093-8094	-LRB-	denotes	(
T2717	8094-8099	NN	denotes	Table
T2718	8100-8101	CD	denotes	1
T2719	8101-8102	-RRB-	denotes	)
T2720	8102-8103	.	denotes	.
T2721	8103-8201	sentence	denotes	Despite the lack of visible deformity, many of the Sam68−/− pups died at birth of unknown causes.
T2722	8104-8111	IN	denotes	Despite
T2723	8169-8173	VBD	denotes	died
T2724	8112-8115	DT	denotes	the
T2725	8116-8120	NN	denotes	lack
T2726	8121-8123	IN	denotes	of
T2727	8124-8131	JJ	denotes	visible
T2728	8132-8141	NN	denotes	deformity
T2729	8141-8143	,	denotes	,
T2730	8143-8147	JJ	denotes	many
T2731	8148-8150	IN	denotes	of
T2732	8151-8154	DT	denotes	the
T2733	8164-8168	NNS	denotes	pups
T2734	8155-8160	NN	denotes	Sam68
T2735	8160-8161	SYM	denotes	−
T2736	8161-8162	HYPH	denotes	/
T2737	8162-8163	SYM	denotes	−
T2738	8174-8176	IN	denotes	at
T2739	8177-8182	NN	denotes	birth
T2740	8183-8185	IN	denotes	of
T2741	8186-8193	JJ	denotes	unknown
T2742	8194-8200	NNS	denotes	causes
T2743	8200-8201	.	denotes	.
T2744	8201-8324	sentence	denotes	Sam68+/- mice were phenotypically normal and Sam68−/− pups that survived the perinatal period invariably lived to old age.
T2745	8202-8207	NN	denotes	Sam68
T2746	8211-8215	NNS	denotes	mice
T2747	8207-8208	SYM	denotes	+
T2748	8208-8209	HYPH	denotes	/
T2749	8209-8210	SYM	denotes	-
T2750	8216-8220	VBD	denotes	were
T2751	8221-8235	RB	denotes	phenotypically
T2752	8236-8242	JJ	denotes	normal
T2753	8243-8246	CC	denotes	and
T2754	8247-8252	NN	denotes	Sam68
T2755	8256-8260	NNS	denotes	pups
T2756	8252-8253	SYM	denotes	−
T2757	8253-8254	HYPH	denotes	/
T2758	8254-8255	SYM	denotes	−
T2759	8307-8312	VBD	denotes	lived
T2760	8261-8265	WDT	denotes	that
T2761	8266-8274	VBD	denotes	survived
T2762	8275-8278	DT	denotes	the
T2763	8289-8295	NN	denotes	period
T2764	8279-8288	JJ	denotes	perinatal
T2765	8296-8306	RB	denotes	invariably
T2766	8313-8315	IN	denotes	to
T2767	8316-8319	JJ	denotes	old
T2768	8320-8323	NN	denotes	age
T2769	8323-8324	.	denotes	.
T2770	8324-8509	sentence	denotes	Despite evidence that Sam68 mRNA is widely expressed and phosphorylated in mitosis [41,42], the Sam68−/− mice did not develop tumors and showed no immunologic or other major illnesses.
T2771	8325-8332	IN	denotes	Despite
T2772	8443-8450	VB	denotes	develop
T2773	8333-8341	NN	denotes	evidence
T2774	8342-8346	IN	denotes	that
T2775	8368-8377	VBN	denotes	expressed
T2776	8347-8352	NN	denotes	Sam68
T2777	8353-8357	NN	denotes	mRNA
T2778	8358-8360	VBZ	denotes	is
T2779	8361-8367	RB	denotes	widely
T2780	8378-8381	CC	denotes	and
T2781	8382-8396	VBN	denotes	phosphorylated
T2782	8397-8399	IN	denotes	in
T2783	8400-8407	NN	denotes	mitosis
T2784	8408-8409	-LRB-	denotes	[
T2785	8412-8414	CD	denotes	42
T2786	8409-8411	CD	denotes	41
T2787	8411-8412	,	denotes	,
T2788	8414-8415	-RRB-	denotes	]
T2789	8415-8417	,	denotes	,
T2790	8417-8420	DT	denotes	the
T2791	8430-8434	NNS	denotes	mice
T2792	8421-8426	NN	denotes	Sam68
T2793	8426-8427	SYM	denotes	−
T2794	8427-8428	HYPH	denotes	/
T2795	8428-8429	SYM	denotes	−
T2796	8435-8438	VBD	denotes	did
T2797	8439-8442	RB	denotes	not
T2798	8451-8457	NNS	denotes	tumors
T2799	8458-8461	CC	denotes	and
T2800	8462-8468	VBD	denotes	showed
T2801	8469-8471	DT	denotes	no
T2802	8499-8508	NNS	denotes	illnesses
T2803	8472-8483	JJ	denotes	immunologic
T2804	8484-8486	CC	denotes	or
T2805	8487-8492	JJ	denotes	other
T2806	8493-8498	JJ	denotes	major
T2807	8508-8509	.	denotes	.
T2808	8509-8648	sentence	denotes	Sam68−/− mice did, however, have difficulty breeding due to male infertility and the females rarely provided adequate care to their young.
T2809	8510-8515	NN	denotes	Sam68
T2810	8519-8523	NNS	denotes	mice
T2811	8515-8516	SYM	denotes	−
T2812	8516-8517	HYPH	denotes	/
T2813	8517-8518	SYM	denotes	−
T2814	8538-8542	VB	denotes	have
T2815	8524-8527	VBD	denotes	did
T2816	8527-8529	,	denotes	,
T2817	8529-8536	RB	denotes	however
T2818	8536-8538	,	denotes	,
T2819	8543-8553	NN	denotes	difficulty
T2820	8554-8562	VBG	denotes	breeding
T2821	8563-8566	IN	denotes	due
T2822	8567-8569	IN	denotes	to
T2823	8570-8574	JJ	denotes	male
T2824	8575-8586	NN	denotes	infertility
T2825	8587-8590	CC	denotes	and
T2826	8591-8594	DT	denotes	the
T2827	8595-8602	NNS	denotes	females
T2828	8610-8618	VBD	denotes	provided
T2829	8603-8609	RB	denotes	rarely
T2830	8619-8627	JJ	denotes	adequate
T2831	8628-8632	NN	denotes	care
T2832	8633-8635	IN	denotes	to
T2833	8636-8641	PRP$	denotes	their
T2834	8642-8647	JJ	denotes	young
T2835	8647-8648	.	denotes	.
T3035	9877-9882	NN	denotes	Sam68
T3036	9883-9893	NN	denotes	Deficiency
T3037	9894-9902	VBZ	denotes	Protects
T3038	9903-9907	NNS	denotes	Mice
T3039	9908-9912	IN	denotes	from
T3040	9913-9916	NN	denotes	Age
T3041	9917-9924	VBN	denotes	Related
T3042	9916-9917	HYPH	denotes	-
T3043	9930-9934	NN	denotes	Loss
T3044	9925-9929	NN	denotes	Bone
T3045	9934-10103	sentence	denotes	Src null animals are known to have bone metabolism defects [48], and since Sam68 is a substrate of Src, we decided to analyze the Sam68 mice for skeletal abnormalities.
T3046	9935-9938	NN	denotes	Src
T3047	9944-9951	NNS	denotes	animals
T3048	9939-9943	JJ	denotes	null
T3049	9956-9961	VBN	denotes	known
T3050	9952-9955	VBP	denotes	are
T3051	9962-9964	TO	denotes	to
T3052	9965-9969	VB	denotes	have
T3053	9970-9974	NN	denotes	bone
T3054	9975-9985	NN	denotes	metabolism
T3055	9986-9993	NNS	denotes	defects
T3056	9994-9995	-LRB-	denotes	[
T3057	9995-9997	CD	denotes	48
T3058	9997-9998	-RRB-	denotes	]
T3059	9998-10000	,	denotes	,
T3060	10000-10003	CC	denotes	and
T3061	10004-10009	IN	denotes	since
T3062	10016-10018	VBZ	denotes	is
T3063	10010-10015	NN	denotes	Sam68
T3064	10042-10049	VBD	denotes	decided
T3065	10019-10020	DT	denotes	a
T3066	10021-10030	NN	denotes	substrate
T3067	10031-10033	IN	denotes	of
T3068	10034-10037	NN	denotes	Src
T3069	10037-10039	,	denotes	,
T3070	10039-10041	PRP	denotes	we
T3071	10050-10052	TO	denotes	to
T3072	10053-10060	VB	denotes	analyze
T3073	10061-10064	DT	denotes	the
T3074	10071-10075	NNS	denotes	mice
T3075	10065-10070	NN	denotes	Sam68
T3076	10076-10079	IN	denotes	for
T3077	10080-10088	JJ	denotes	skeletal
T3078	10089-10102	NNS	denotes	abnormalities
T3079	10102-10103	.	denotes	.
T3080	10103-10209	sentence	denotes	Cohorts of Sam68+/+ and Sam68−/− mice were euthanized at 4 and 12 months of age for skeletal phenotyping.
T3081	10104-10111	NNS	denotes	Cohorts
T3082	10147-10157	VBN	denotes	euthanized
T3083	10112-10114	IN	denotes	of
T3084	10115-10120	NN	denotes	Sam68
T3085	10137-10141	NNS	denotes	mice
T3086	10120-10121	SYM	denotes	+
T3087	10121-10122	HYPH	denotes	/
T3088	10122-10123	SYM	denotes	+
T3089	10124-10127	CC	denotes	and
T3090	10128-10133	NN	denotes	Sam68
T3091	10133-10134	SYM	denotes	−
T3092	10134-10135	HYPH	denotes	/
T3093	10135-10136	SYM	denotes	−
T3094	10142-10146	VBD	denotes	were
T3095	10158-10160	IN	denotes	at
T3096	10161-10162	CD	denotes	4
T3097	10170-10176	NNS	denotes	months
T3098	10163-10166	CC	denotes	and
T3099	10167-10169	CD	denotes	12
T3100	10177-10179	IN	denotes	of
T3101	10180-10183	NN	denotes	age
T3102	10184-10187	IN	denotes	for
T3103	10188-10196	JJ	denotes	skeletal
T3104	10197-10208	NN	denotes	phenotyping
T3105	10208-10209	.	denotes	.
T3106	10209-10371	sentence	denotes	To minimize differences in the bone phenotype that might arise secondary to gender or weight differences, we selected age-matched female mice for these analyses.
T3107	10210-10212	TO	denotes	To
T3108	10213-10221	VB	denotes	minimize
T3109	10319-10327	VBD	denotes	selected
T3110	10222-10233	NNS	denotes	differences
T3111	10234-10236	IN	denotes	in
T3112	10237-10240	DT	denotes	the
T3113	10246-10255	NN	denotes	phenotype
T3114	10241-10245	NN	denotes	bone
T3115	10256-10260	WDT	denotes	that
T3116	10267-10272	VB	denotes	arise
T3117	10261-10266	MD	denotes	might
T3118	10273-10282	JJ	denotes	secondary
T3119	10283-10285	IN	denotes	to
T3120	10286-10292	NN	denotes	gender
T3121	10303-10314	NNS	denotes	differences
T3122	10293-10295	CC	denotes	or
T3123	10296-10302	NN	denotes	weight
T3124	10314-10316	,	denotes	,
T3125	10316-10318	PRP	denotes	we
T3126	10328-10331	NN	denotes	age
T3127	10332-10339	VBN	denotes	matched
T3128	10331-10332	HYPH	denotes	-
T3129	10347-10351	NNS	denotes	mice
T3130	10340-10346	JJ	denotes	female
T3131	10352-10355	IN	denotes	for
T3132	10356-10361	DT	denotes	these
T3133	10362-10370	NNS	denotes	analyses
T3134	10370-10371	.	denotes	.
T3135	10371-10619	sentence	denotes	The female mice demonstrated similar increases in body weight, although 4-month-old Sam68−/− mice weighed less than Sam68+/+ mice, and similar changes in bone lengths in the axial and appendicular skeleton between 4 and 12 months of age (Table 2).
T3136	10372-10375	DT	denotes	The
T3137	10383-10387	NNS	denotes	mice
T3138	10376-10382	JJ	denotes	female
T3139	10388-10400	VBD	denotes	demonstrated
T3140	10401-10408	JJ	denotes	similar
T3141	10409-10418	NNS	denotes	increases
T3142	10419-10421	IN	denotes	in
T3143	10422-10426	NN	denotes	body
T3144	10427-10433	NN	denotes	weight
T3145	10433-10435	,	denotes	,
T3146	10470-10477	VBD	denotes	weighed
T3147	10435-10443	IN	denotes	although
T3148	10444-10445	CD	denotes	4
T3149	10446-10451	NN	denotes	month
T3150	10445-10446	HYPH	denotes	-
T3151	10452-10455	JJ	denotes	old
T3152	10451-10452	HYPH	denotes	-
T3153	10465-10469	NNS	denotes	mice
T3154	10456-10461	NN	denotes	Sam68
T3155	10461-10462	SYM	denotes	−
T3156	10462-10463	HYPH	denotes	/
T3157	10463-10464	SYM	denotes	−
T3158	10478-10482	JJR	denotes	less
T3159	10483-10487	IN	denotes	than
T3160	10488-10493	NN	denotes	Sam68
T3161	10497-10501	NNS	denotes	mice
T3162	10493-10494	SYM	denotes	+
T3163	10494-10495	HYPH	denotes	/
T3164	10495-10496	SYM	denotes	+
T3165	10501-10503	,	denotes	,
T3166	10503-10506	CC	denotes	and
T3167	10507-10514	JJ	denotes	similar
T3168	10515-10522	NNS	denotes	changes
T3169	10523-10525	IN	denotes	in
T3170	10526-10530	NN	denotes	bone
T3171	10531-10538	NNS	denotes	lengths
T3172	10539-10541	IN	denotes	in
T3173	10542-10545	DT	denotes	the
T3174	10569-10577	NN	denotes	skeleton
T3175	10546-10551	JJ	denotes	axial
T3176	10552-10555	CC	denotes	and
T3177	10556-10568	JJ	denotes	appendicular
T3178	10578-10585	IN	denotes	between
T3179	10586-10587	CD	denotes	4
T3180	10595-10601	NNS	denotes	months
T3181	10588-10591	CC	denotes	and
T3182	10592-10594	CD	denotes	12
T3183	10602-10604	IN	denotes	of
T3184	10605-10608	NN	denotes	age
T3185	10609-10610	-LRB-	denotes	(
T3186	10610-10615	NN	denotes	Table
T3187	10616-10617	CD	denotes	2
T3188	10617-10618	-RRB-	denotes	)
T3189	10618-10619	.	denotes	.
T3190	10619-10990	sentence	denotes	Faxitron radiography (Faxitron X-ray Corporation, Wheeling, Illinois, United States) (Figure 3A) and micro–computed tomography (CT) (Figure 3B) revealed significant cortical thinning (arrow) and a reduction in metaphyseal bone (asterisk) in the distal femora of 12-month-old Sam68+/+ mice compared with 4-month-old mice of either genotype and 12-month-old Sam68−/− mice.
T3191	10620-10628	NNP	denotes	Faxitron
T3192	10629-10640	NN	denotes	radiography
T3193	10764-10772	VBD	denotes	revealed
T3194	10641-10642	-LRB-	denotes	(
T3195	10657-10668	NNP	denotes	Corporation
T3196	10642-10650	NNP	denotes	Faxitron
T3197	10651-10652	NN	denotes	X
T3198	10653-10656	NN	denotes	ray
T3199	10652-10653	HYPH	denotes	-
T3200	10668-10670	,	denotes	,
T3201	10670-10678	NNP	denotes	Wheeling
T3202	10678-10680	,	denotes	,
T3203	10680-10688	NNP	denotes	Illinois
T3204	10688-10690	,	denotes	,
T3205	10690-10696	NNP	denotes	United
T3206	10697-10703	NNP	denotes	States
T3207	10703-10704	-RRB-	denotes	)
T3208	10705-10706	-LRB-	denotes	(
T3209	10713-10715	NN	denotes	3A
T3210	10706-10712	NN	denotes	Figure
T3211	10715-10716	-RRB-	denotes	)
T3212	10717-10720	CC	denotes	and
T3213	10721-10735	VBN	denotes	micro–computed
T3214	10736-10746	NN	denotes	tomography
T3215	10747-10748	-LRB-	denotes	(
T3216	10748-10750	NN	denotes	CT
T3217	10750-10751	-RRB-	denotes	)
T3218	10752-10753	-LRB-	denotes	(
T3219	10760-10762	NN	denotes	3B
T3220	10753-10759	NN	denotes	Figure
T3221	10762-10763	-RRB-	denotes	)
T3222	10773-10784	JJ	denotes	significant
T3223	10794-10802	NN	denotes	thinning
T3224	10785-10793	JJ	denotes	cortical
T3225	10803-10804	-LRB-	denotes	(
T3226	10804-10809	NN	denotes	arrow
T3227	10809-10810	-RRB-	denotes	)
T3228	10811-10814	CC	denotes	and
T3229	10815-10816	DT	denotes	a
T3230	10817-10826	NN	denotes	reduction
T3231	10827-10829	IN	denotes	in
T3232	10830-10841	JJ	denotes	metaphyseal
T3233	10842-10846	NN	denotes	bone
T3234	10847-10848	-LRB-	denotes	(
T3235	10848-10856	NN	denotes	asterisk
T3236	10856-10857	-RRB-	denotes	)
T3237	10858-10860	IN	denotes	in
T3238	10861-10864	DT	denotes	the
T3239	10872-10878	NNS	denotes	femora
T3240	10865-10871	JJ	denotes	distal
T3241	10879-10881	IN	denotes	of
T3242	10882-10884	CD	denotes	12
T3243	10885-10890	NN	denotes	month
T3244	10884-10885	HYPH	denotes	-
T3245	10891-10894	JJ	denotes	old
T3246	10890-10891	HYPH	denotes	-
T3247	10904-10908	NNS	denotes	mice
T3248	10895-10900	NN	denotes	Sam68
T3249	10900-10901	SYM	denotes	+
T3250	10901-10902	HYPH	denotes	/
T3251	10902-10903	SYM	denotes	+
T3252	10909-10917	VBN	denotes	compared
T3253	10918-10922	IN	denotes	with
T3254	10923-10924	CD	denotes	4
T3255	10925-10930	NN	denotes	month
T3256	10924-10925	HYPH	denotes	-
T3257	10931-10934	JJ	denotes	old
T3258	10930-10931	HYPH	denotes	-
T3259	10935-10939	NNS	denotes	mice
T3260	10940-10942	IN	denotes	of
T3261	10943-10949	CC	denotes	either
T3262	10950-10958	NN	denotes	genotype
T3263	10959-10962	CC	denotes	and
T3264	10963-10965	CD	denotes	12
T3265	10966-10971	NN	denotes	month
T3266	10965-10966	HYPH	denotes	-
T3267	10972-10975	JJ	denotes	old
T3268	10971-10972	HYPH	denotes	-
T3269	10985-10989	NNS	denotes	mice
T3270	10976-10981	NN	denotes	Sam68
T3271	10981-10982	SYM	denotes	−
T3272	10982-10983	HYPH	denotes	/
T3273	10983-10984	SYM	denotes	−
T3274	10989-10990	.	denotes	.
T3275	10990-11177	sentence	denotes	Similar reductions in trabecular bone were shown by Faxitron and micro-CT in the fifth lumbar vertebrae of the 12-month-old Sam68+/+ mice but not in the Sam68−/− mice (unpublished data).
T3276	10991-10998	JJ	denotes	Similar
T3277	10999-11009	NNS	denotes	reductions
T3278	11034-11039	VBN	denotes	shown
T3279	11010-11012	IN	denotes	in
T3280	11013-11023	JJ	denotes	trabecular
T3281	11024-11028	NN	denotes	bone
T3282	11029-11033	VBD	denotes	were
T3283	11040-11042	IN	denotes	by
T3284	11043-11051	NNP	denotes	Faxitron
T3285	11052-11055	CC	denotes	and
T3286	11056-11064	NN	denotes	micro-CT
T3287	11065-11067	IN	denotes	in
T3288	11068-11071	DT	denotes	the
T3289	11085-11094	NNS	denotes	vertebrae
T3290	11072-11077	JJ	denotes	fifth
T3291	11078-11084	NN	denotes	lumbar
T3292	11095-11097	IN	denotes	of
T3293	11098-11101	DT	denotes	the
T3294	11124-11128	NNS	denotes	mice
T3295	11102-11104	CD	denotes	12
T3296	11105-11110	NN	denotes	month
T3297	11104-11105	HYPH	denotes	-
T3298	11111-11114	JJ	denotes	old
T3299	11110-11111	HYPH	denotes	-
T3300	11115-11120	NN	denotes	Sam68
T3301	11120-11121	SYM	denotes	+
T3302	11121-11122	HYPH	denotes	/
T3303	11122-11123	SYM	denotes	+
T3304	11129-11132	CC	denotes	but
T3305	11133-11136	RB	denotes	not
T3306	11137-11139	IN	denotes	in
T3307	11140-11143	DT	denotes	the
T3308	11153-11157	NNS	denotes	mice
T3309	11144-11149	NN	denotes	Sam68
T3310	11149-11150	SYM	denotes	−
T3311	11150-11151	HYPH	denotes	/
T3312	11151-11152	SYM	denotes	−
T3313	11158-11159	-LRB-	denotes	(
T3314	11171-11175	NNS	denotes	data
T3315	11159-11170	JJ	denotes	unpublished
T3316	11175-11176	-RRB-	denotes	)
T3317	11176-11177	.	denotes	.
T3318	11177-11460	sentence	denotes	Total body bone mineral content (BMC), quantified with a Lunar PIXImus mouse densitometer (GE-Lunar, Madison, Wisconsin, United States), increased in both Sam68+/+ and Sam68−/− mice between 4 months and 12 months of age, but only reached significance in the Sam68−/− mice (Table 2).
T3319	11178-11183	JJ	denotes	Total
T3320	11202-11209	NN	denotes	content
T3321	11184-11188	NN	denotes	body
T3322	11189-11193	NN	denotes	bone
T3323	11194-11201	NN	denotes	mineral
T3324	11315-11324	VBD	denotes	increased
T3325	11210-11211	-LRB-	denotes	(
T3326	11211-11214	NN	denotes	BMC
T3327	11214-11215	-RRB-	denotes	)
T3328	11215-11217	,	denotes	,
T3329	11217-11227	VBN	denotes	quantified
T3330	11228-11232	IN	denotes	with
T3331	11233-11234	DT	denotes	a
T3332	11255-11267	NN	denotes	densitometer
T3333	11235-11240	JJ	denotes	Lunar
T3334	11241-11248	NNP	denotes	PIXImus
T3335	11249-11254	NN	denotes	mouse
T3336	11268-11269	-LRB-	denotes	(
T3337	11272-11277	NNP	denotes	Lunar
T3338	11269-11271	NNP	denotes	GE
T3339	11271-11272	HYPH	denotes	-
T3340	11277-11279	,	denotes	,
T3341	11279-11286	NNP	denotes	Madison
T3342	11286-11288	,	denotes	,
T3343	11288-11297	NNP	denotes	Wisconsin
T3344	11297-11299	,	denotes	,
T3345	11299-11305	NNP	denotes	United
T3346	11306-11312	NNP	denotes	States
T3347	11312-11313	-RRB-	denotes	)
T3348	11313-11315	,	denotes	,
T3349	11325-11327	IN	denotes	in
T3350	11328-11332	CC	denotes	both
T3351	11333-11338	NN	denotes	Sam68
T3352	11355-11359	NNS	denotes	mice
T3353	11338-11339	SYM	denotes	+
T3354	11339-11340	HYPH	denotes	/
T3355	11340-11341	SYM	denotes	+
T3356	11342-11345	CC	denotes	and
T3357	11346-11351	NN	denotes	Sam68
T3358	11351-11352	SYM	denotes	−
T3359	11352-11353	HYPH	denotes	/
T3360	11353-11354	SYM	denotes	−
T3361	11360-11367	IN	denotes	between
T3362	11368-11369	CD	denotes	4
T3363	11370-11376	NNS	denotes	months
T3364	11377-11380	CC	denotes	and
T3365	11381-11383	CD	denotes	12
T3366	11384-11390	NNS	denotes	months
T3367	11391-11393	IN	denotes	of
T3368	11394-11397	NN	denotes	age
T3369	11397-11399	,	denotes	,
T3370	11399-11402	CC	denotes	but
T3371	11403-11407	RB	denotes	only
T3372	11408-11415	VBD	denotes	reached
T3373	11416-11428	NN	denotes	significance
T3374	11429-11431	IN	denotes	in
T3375	11432-11435	DT	denotes	the
T3376	11445-11449	NNS	denotes	mice
T3377	11436-11441	NN	denotes	Sam68
T3378	11441-11442	SYM	denotes	−
T3379	11442-11443	HYPH	denotes	/
T3380	11443-11444	SYM	denotes	−
T3381	11450-11451	-LRB-	denotes	(
T3382	11451-11456	NN	denotes	Table
T3383	11457-11458	CD	denotes	2
T3384	11458-11459	-RRB-	denotes	)
T3385	11459-11460	.	denotes	.
T3386	11460-11554	sentence	denotes	Similarly, a greater increase in BMC was seen in the femur and vertebra in the Sam68−/− mice.
T3387	11461-11470	RB	denotes	Similarly
T3388	11502-11506	VBN	denotes	seen
T3389	11470-11472	,	denotes	,
T3390	11472-11473	DT	denotes	a
T3391	11482-11490	NN	denotes	increase
T3392	11474-11481	JJR	denotes	greater
T3393	11491-11493	IN	denotes	in
T3394	11494-11497	NN	denotes	BMC
T3395	11498-11501	VBD	denotes	was
T3396	11507-11509	IN	denotes	in
T3397	11510-11513	DT	denotes	the
T3398	11514-11519	NN	denotes	femur
T3399	11520-11523	CC	denotes	and
T3400	11524-11532	NN	denotes	vertebra
T3401	11533-11535	IN	denotes	in
T3402	11536-11539	DT	denotes	the
T3403	11549-11553	NNS	denotes	mice
T3404	11540-11545	NN	denotes	Sam68
T3405	11545-11546	SYM	denotes	−
T3406	11546-11547	HYPH	denotes	/
T3407	11547-11548	SYM	denotes	−
T3408	11553-11554	.	denotes	.
T3409	11554-11760	sentence	denotes	Bone mineral density (BMD) remained constant or decreased in the wild type mice but increased significantly in the total body and in the femoral and vertebral regions of interest in the Sam68−/− (Table 2).
T3410	11555-11559	NN	denotes	Bone
T3411	11560-11567	NN	denotes	mineral
T3412	11568-11575	NN	denotes	density
T3413	11582-11590	VBD	denotes	remained
T3414	11576-11577	-LRB-	denotes	(
T3415	11577-11580	NN	denotes	BMD
T3416	11580-11581	-RRB-	denotes	)
T3417	11591-11599	JJ	denotes	constant
T3418	11600-11602	CC	denotes	or
T3419	11603-11612	VBN	denotes	decreased
T3420	11613-11615	IN	denotes	in
T3421	11616-11619	DT	denotes	the
T3422	11630-11634	NNS	denotes	mice
T3423	11620-11624	JJ	denotes	wild
T3424	11625-11629	NN	denotes	type
T3425	11635-11638	CC	denotes	but
T3426	11639-11648	VBD	denotes	increased
T3427	11649-11662	RB	denotes	significantly
T3428	11663-11665	IN	denotes	in
T3429	11666-11669	DT	denotes	the
T3430	11676-11680	NN	denotes	body
T3431	11670-11675	JJ	denotes	total
T3432	11681-11684	CC	denotes	and
T3433	11685-11687	IN	denotes	in
T3434	11688-11691	DT	denotes	the
T3435	11714-11721	NNS	denotes	regions
T3436	11692-11699	JJ	denotes	femoral
T3437	11700-11703	CC	denotes	and
T3438	11704-11713	JJ	denotes	vertebral
T3439	11722-11724	IN	denotes	of
T3440	11725-11733	NN	denotes	interest
T3441	11734-11736	IN	denotes	in
T3442	11737-11740	DT	denotes	the
T3443	11741-11746	NN	denotes	Sam68
T3444	11746-11747	SYM	denotes	−
T3445	11747-11748	HYPH	denotes	/
T3446	11748-11749	SYM	denotes	−
T3447	11750-11751	-LRB-	denotes	(
T3448	11751-11756	NN	denotes	Table
T3449	11757-11758	CD	denotes	2
T3450	11758-11759	-RRB-	denotes	)
T3451	11759-11760	.	denotes	.
T3452	11760-11899	sentence	denotes	These data showed that Sam68−/− mice continued to thrive and accrue bone in the axial and appendicular skeleton for longer than 12 months.
T3453	11761-11766	DT	denotes	These
T3454	11767-11771	NNS	denotes	data
T3455	11772-11778	VBD	denotes	showed
T3456	11779-11783	IN	denotes	that
T3457	11798-11807	VBD	denotes	continued
T3458	11784-11789	NN	denotes	Sam68
T3459	11793-11797	NNS	denotes	mice
T3460	11789-11790	SYM	denotes	−
T3461	11790-11791	HYPH	denotes	/
T3462	11791-11792	SYM	denotes	−
T3463	11808-11810	TO	denotes	to
T3464	11811-11817	VB	denotes	thrive
T3465	11818-11821	CC	denotes	and
T3466	11822-11828	VB	denotes	accrue
T3467	11829-11833	NN	denotes	bone
T3468	11834-11836	IN	denotes	in
T3469	11837-11840	DT	denotes	the
T3470	11864-11872	NN	denotes	skeleton
T3471	11841-11846	JJ	denotes	axial
T3472	11847-11850	CC	denotes	and
T3473	11851-11863	JJ	denotes	appendicular
T3474	11873-11876	IN	denotes	for
T3475	11877-11883	JJR	denotes	longer
T3476	11889-11891	CD	denotes	12
T3477	11884-11888	IN	denotes	than
T3478	11892-11898	NNS	denotes	months
T3479	11898-11899	.	denotes	.
T3480	11899-12045	sentence	denotes	This was in contrast to the situation in age-matched, littermate controls in which a significant amount of bone was lost over the same timeframe.
T3481	11900-11904	DT	denotes	This
T3482	11905-11908	VBD	denotes	was
T3483	11909-11911	IN	denotes	in
T3484	11912-11920	NN	denotes	contrast
T3485	11921-11923	IN	denotes	to
T3486	11924-11927	DT	denotes	the
T3487	11928-11937	NN	denotes	situation
T3488	11938-11940	IN	denotes	in
T3489	11941-11944	NN	denotes	age
T3490	11945-11952	VBN	denotes	matched
T3491	11944-11945	HYPH	denotes	-
T3492	11965-11973	NNS	denotes	controls
T3493	11952-11954	,	denotes	,
T3494	11954-11964	NN	denotes	littermate
T3495	11974-11976	IN	denotes	in
T3496	12016-12020	VBN	denotes	lost
T3497	11977-11982	WDT	denotes	which
T3498	11983-11984	DT	denotes	a
T3499	11997-12003	NN	denotes	amount
T3500	11985-11996	JJ	denotes	significant
T3501	12004-12006	IN	denotes	of
T3502	12007-12011	NN	denotes	bone
T3503	12012-12015	VBD	denotes	was
T3504	12021-12025	IN	denotes	over
T3505	12026-12029	DT	denotes	the
T3506	12035-12044	NN	denotes	timeframe
T3507	12030-12034	JJ	denotes	same
T3508	12044-12045	.	denotes	.
T3587	13332-13337	CD	denotes	Three
T3588	13338-13349	JJ	denotes	Dimensional
T3589	13337-13338	HYPH	denotes	-
T3590	13350-13362	NN	denotes	Architecture
T3591	13374-13383	VBN	denotes	Preserved
T3592	13363-13365	IN	denotes	of
T3593	13366-13370	NN	denotes	Bone
T3594	13371-13373	VBZ	denotes	Is
T3595	13384-13386	IN	denotes	in
T3596	13387-13391	VBN	denotes	Aged
T3597	13401-13405	NNS	denotes	Mice
T3598	13392-13397	NN	denotes	Sam68
T3599	13397-13398	SYM	denotes	−
T3600	13398-13399	HYPH	denotes	/
T3601	13399-13400	SYM	denotes	−
T3602	13405-13627	sentence	denotes	Bone loss and compromised architecture are characteristic features of the skeletons of aged C57BL/6 mice and resemble the clinical features of age-related bone loss in humans that can predispose an individual to fracture.
T3603	13406-13410	NN	denotes	Bone
T3604	13411-13415	NN	denotes	loss
T3605	13445-13448	VBP	denotes	are
T3606	13416-13419	CC	denotes	and
T3607	13420-13431	VBN	denotes	compromised
T3608	13432-13444	NN	denotes	architecture
T3609	13449-13463	JJ	denotes	characteristic
T3610	13464-13472	NNS	denotes	features
T3611	13473-13475	IN	denotes	of
T3612	13476-13479	DT	denotes	the
T3613	13480-13489	NNS	denotes	skeletons
T3614	13490-13492	IN	denotes	of
T3615	13493-13497	JJ	denotes	aged
T3616	13506-13510	NNS	denotes	mice
T3617	13498-13503	NN	denotes	C57BL
T3618	13503-13504	HYPH	denotes	/
T3619	13504-13505	CD	denotes	6
T3620	13511-13514	CC	denotes	and
T3621	13515-13523	VBP	denotes	resemble
T3622	13524-13527	DT	denotes	the
T3623	13537-13545	NNS	denotes	features
T3624	13528-13536	JJ	denotes	clinical
T3625	13546-13548	IN	denotes	of
T3626	13549-13552	NN	denotes	age
T3627	13553-13560	VBN	denotes	related
T3628	13552-13553	HYPH	denotes	-
T3629	13566-13570	NN	denotes	loss
T3630	13561-13565	NN	denotes	bone
T3631	13571-13573	IN	denotes	in
T3632	13574-13580	NNS	denotes	humans
T3633	13581-13585	WDT	denotes	that
T3634	13590-13600	VB	denotes	predispose
T3635	13586-13589	MD	denotes	can
T3636	13601-13603	DT	denotes	an
T3637	13604-13614	NN	denotes	individual
T3638	13615-13617	IN	denotes	to
T3639	13618-13626	NN	denotes	fracture
T3640	13626-13627	.	denotes	.
T3641	13627-13933	sentence	denotes	Quantification of the micro-CT data shown in Figure 3B confirmed the reduction in bone volume compared with tissue volume (BV/TV; Figure 4A, left) in the 12-month-old Sam68+/+ mice (hatched bars) compared with 4-month-old mice of both genotypes (solid bars) and 12-month-old Sam68−/− mice (stippled bars).
T3642	13628-13642	NN	denotes	Quantification
T3643	13683-13692	VBD	denotes	confirmed
T3644	13643-13645	IN	denotes	of
T3645	13646-13649	DT	denotes	the
T3646	13659-13663	NNS	denotes	data
T3647	13650-13658	NN	denotes	micro-CT
T3648	13664-13669	VBN	denotes	shown
T3649	13670-13672	IN	denotes	in
T3650	13673-13679	NN	denotes	Figure
T3651	13680-13682	NN	denotes	3B
T3652	13693-13696	DT	denotes	the
T3653	13697-13706	NN	denotes	reduction
T3654	13707-13709	IN	denotes	in
T3655	13710-13714	NN	denotes	bone
T3656	13715-13721	NN	denotes	volume
T3657	13722-13730	VBN	denotes	compared
T3658	13731-13735	IN	denotes	with
T3659	13736-13742	NN	denotes	tissue
T3660	13743-13749	NN	denotes	volume
T3661	13750-13751	-LRB-	denotes	(
T3662	13765-13767	NN	denotes	4A
T3663	13751-13753	NN	denotes	BV
T3664	13754-13756	NN	denotes	TV
T3665	13753-13754	HYPH	denotes	/
T3666	13756-13757	:	denotes	;
T3667	13758-13764	NN	denotes	Figure
T3668	13767-13769	,	denotes	,
T3669	13769-13773	JJ	denotes	left
T3670	13773-13774	-RRB-	denotes	)
T3671	13775-13777	IN	denotes	in
T3672	13778-13781	DT	denotes	the
T3673	13804-13808	NNS	denotes	mice
T3674	13782-13784	CD	denotes	12
T3675	13785-13790	NN	denotes	month
T3676	13784-13785	HYPH	denotes	-
T3677	13791-13794	JJ	denotes	old
T3678	13790-13791	HYPH	denotes	-
T3679	13795-13800	NN	denotes	Sam68
T3680	13800-13801	SYM	denotes	+
T3681	13801-13802	HYPH	denotes	/
T3682	13802-13803	SYM	denotes	+
T3683	13809-13810	-LRB-	denotes	(
T3684	13818-13822	NNS	denotes	bars
T3685	13810-13817	VBN	denotes	hatched
T3686	13822-13823	-RRB-	denotes	)
T3687	13824-13832	VBN	denotes	compared
T3688	13833-13837	IN	denotes	with
T3689	13838-13839	CD	denotes	4
T3690	13840-13845	NN	denotes	month
T3691	13839-13840	HYPH	denotes	-
T3692	13846-13849	JJ	denotes	old
T3693	13845-13846	HYPH	denotes	-
T3694	13850-13854	NNS	denotes	mice
T3695	13855-13857	IN	denotes	of
T3696	13858-13862	DT	denotes	both
T3697	13863-13872	NNS	denotes	genotypes
T3698	13873-13874	-LRB-	denotes	(
T3699	13880-13884	NNS	denotes	bars
T3700	13874-13879	JJ	denotes	solid
T3701	13884-13885	-RRB-	denotes	)
T3702	13886-13889	CC	denotes	and
T3703	13890-13892	CD	denotes	12
T3704	13893-13898	NN	denotes	month
T3705	13892-13893	HYPH	denotes	-
T3706	13899-13902	JJ	denotes	old
T3707	13898-13899	HYPH	denotes	-
T3708	13912-13916	NNS	denotes	mice
T3709	13903-13908	NN	denotes	Sam68
T3710	13908-13909	SYM	denotes	−
T3711	13909-13910	HYPH	denotes	/
T3712	13910-13911	SYM	denotes	−
T3713	13917-13918	-LRB-	denotes	(
T3714	13927-13931	NNS	denotes	bars
T3715	13918-13926	VBN	denotes	stippled
T3716	13931-13932	-RRB-	denotes	)
T3717	13932-13933	.	denotes	.
T3718	13933-14130	sentence	denotes	This was associated with a significant increase (p < 0.01; denoted by the asterisks) in the structure model index, which measures the ratio of plate-like to rod-like structures (Figure 4A, right).
T3719	13934-13938	DT	denotes	This
T3720	13943-13953	VBN	denotes	associated
T3721	13939-13942	VBD	denotes	was
T3722	13954-13958	IN	denotes	with
T3723	13959-13960	DT	denotes	a
T3724	13973-13981	NN	denotes	increase
T3725	13961-13972	JJ	denotes	significant
T3726	13982-13983	-LRB-	denotes	(
T3727	13993-14000	VBN	denotes	denoted
T3728	13983-13984	NN	denotes	p
T3729	13987-13991	CD	denotes	0.01
T3730	13985-13986	SYM	denotes	<
T3731	13991-13992	:	denotes	;
T3732	14001-14003	IN	denotes	by
T3733	14004-14007	DT	denotes	the
T3734	14008-14017	NNS	denotes	asterisks
T3735	14017-14018	-RRB-	denotes	)
T3736	14019-14021	IN	denotes	in
T3737	14022-14025	DT	denotes	the
T3738	14042-14047	NN	denotes	index
T3739	14026-14035	NN	denotes	structure
T3740	14036-14041	NN	denotes	model
T3741	14047-14049	,	denotes	,
T3742	14049-14054	WDT	denotes	which
T3743	14055-14063	VBZ	denotes	measures
T3744	14064-14067	DT	denotes	the
T3745	14068-14073	NN	denotes	ratio
T3746	14074-14076	IN	denotes	of
T3747	14077-14082	NN	denotes	plate
T3748	14083-14087	JJ	denotes	like
T3749	14082-14083	HYPH	denotes	-
T3750	14088-14090	IN	denotes	to
T3751	14091-14094	NN	denotes	rod
T3752	14095-14099	JJ	denotes	like
T3753	14094-14095	HYPH	denotes	-
T3754	14100-14110	NNS	denotes	structures
T3755	14111-14112	-LRB-	denotes	(
T3756	14119-14121	NN	denotes	4A
T3757	14112-14118	NN	denotes	Figure
T3758	14121-14123	,	denotes	,
T3759	14123-14128	NN	denotes	right
T3760	14128-14129	-RRB-	denotes	)
T3761	14129-14130	.	denotes	.
T3762	14130-14365	sentence	denotes	A quantifiable increase in the mean trabecular separation (Tb.Sp) (unpublished data) in 12-month-old Sam68+/+ mice was due to an increase in the percentage of spaces falling in the range of 350 to 700 μm (Figure 4B, red hatched line).
T3763	14131-14132	DT	denotes	A
T3764	14146-14154	NN	denotes	increase
T3765	14133-14145	JJ	denotes	quantifiable
T3766	14246-14249	VBD	denotes	was
T3767	14155-14157	IN	denotes	in
T3768	14158-14161	DT	denotes	the
T3769	14178-14188	NN	denotes	separation
T3770	14162-14166	NN	denotes	mean
T3771	14167-14177	JJ	denotes	trabecular
T3772	14189-14190	-LRB-	denotes	(
T3773	14190-14195	NN	denotes	Tb.Sp
T3774	14195-14196	-RRB-	denotes	)
T3775	14197-14198	-LRB-	denotes	(
T3776	14210-14214	NNS	denotes	data
T3777	14198-14209	JJ	denotes	unpublished
T3778	14214-14215	-RRB-	denotes	)
T3779	14216-14218	IN	denotes	in
T3780	14219-14221	CD	denotes	12
T3781	14222-14227	NN	denotes	month
T3782	14221-14222	HYPH	denotes	-
T3783	14228-14231	JJ	denotes	old
T3784	14227-14228	HYPH	denotes	-
T3785	14241-14245	NNS	denotes	mice
T3786	14232-14237	NN	denotes	Sam68
T3787	14237-14238	SYM	denotes	+
T3788	14238-14239	HYPH	denotes	/
T3789	14239-14240	SYM	denotes	+
T3790	14250-14253	IN	denotes	due
T3791	14254-14256	IN	denotes	to
T3792	14257-14259	DT	denotes	an
T3793	14260-14268	NN	denotes	increase
T3794	14269-14271	IN	denotes	in
T3795	14272-14275	DT	denotes	the
T3796	14276-14286	NN	denotes	percentage
T3797	14287-14289	IN	denotes	of
T3798	14290-14296	NNS	denotes	spaces
T3799	14297-14304	VBG	denotes	falling
T3800	14305-14307	IN	denotes	in
T3801	14308-14311	DT	denotes	the
T3802	14312-14317	NN	denotes	range
T3803	14318-14320	IN	denotes	of
T3804	14321-14324	CD	denotes	350
T3805	14328-14331	CD	denotes	700
T3806	14325-14327	IN	denotes	to
T3807	14332-14334	NN	denotes	μm
T3808	14335-14336	-LRB-	denotes	(
T3809	14343-14345	NN	denotes	4B
T3810	14336-14342	NN	denotes	Figure
T3811	14345-14347	,	denotes	,
T3812	14347-14350	JJ	denotes	red
T3813	14359-14363	NN	denotes	line
T3814	14351-14358	VBN	denotes	hatched
T3815	14363-14364	-RRB-	denotes	)
T3816	14364-14365	.	denotes	.
T3817	14365-14459	sentence	denotes	Trabecular thickness remained constant among the different groups of mice (unpublished data).
T3818	14366-14376	JJ	denotes	Trabecular
T3819	14377-14386	NN	denotes	thickness
T3820	14387-14395	VBD	denotes	remained
T3821	14396-14404	JJ	denotes	constant
T3822	14405-14410	IN	denotes	among
T3823	14411-14414	DT	denotes	the
T3824	14425-14431	NNS	denotes	groups
T3825	14415-14424	JJ	denotes	different
T3826	14432-14434	IN	denotes	of
T3827	14435-14439	NNS	denotes	mice
T3828	14440-14441	-LRB-	denotes	(
T3829	14453-14457	NNS	denotes	data
T3830	14441-14452	JJ	denotes	unpublished
T3831	14457-14458	-RRB-	denotes	)
T3832	14458-14459	.	denotes	.
T3833	14459-14647	sentence	denotes	In effect, this meant that there were fewer trabeculae, rather than equivalent numbers of thin trabeculae, in the 12-month-old Sam68+/+ mice compared with any of the other groups of mice.
T3834	14460-14462	IN	denotes	In
T3835	14476-14481	VBD	denotes	meant
T3836	14463-14469	NN	denotes	effect
T3837	14469-14471	,	denotes	,
T3838	14471-14475	DT	denotes	this
T3839	14482-14486	IN	denotes	that
T3840	14493-14497	VBD	denotes	were
T3841	14487-14492	EX	denotes	there
T3842	14498-14503	JJR	denotes	fewer
T3843	14504-14514	NNS	denotes	trabeculae
T3844	14514-14516	,	denotes	,
T3845	14516-14522	RB	denotes	rather
T3846	14523-14527	IN	denotes	than
T3847	14528-14538	JJ	denotes	equivalent
T3848	14539-14546	NNS	denotes	numbers
T3849	14547-14549	IN	denotes	of
T3850	14550-14554	JJ	denotes	thin
T3851	14555-14565	NNS	denotes	trabeculae
T3852	14565-14567	,	denotes	,
T3853	14567-14569	IN	denotes	in
T3854	14570-14573	DT	denotes	the
T3855	14596-14600	NNS	denotes	mice
T3856	14574-14576	CD	denotes	12
T3857	14577-14582	NN	denotes	month
T3858	14576-14577	HYPH	denotes	-
T3859	14583-14586	JJ	denotes	old
T3860	14582-14583	HYPH	denotes	-
T3861	14587-14592	NN	denotes	Sam68
T3862	14592-14593	SYM	denotes	+
T3863	14593-14594	HYPH	denotes	/
T3864	14594-14595	SYM	denotes	+
T3865	14601-14609	VBN	denotes	compared
T3866	14610-14614	IN	denotes	with
T3867	14615-14618	DT	denotes	any
T3868	14619-14621	IN	denotes	of
T3869	14622-14625	DT	denotes	the
T3870	14632-14638	NNS	denotes	groups
T3871	14626-14631	JJ	denotes	other
T3872	14639-14641	IN	denotes	of
T3873	14642-14646	NNS	denotes	mice
T3874	14646-14647	.	denotes	.
T4163	15537-15541	NN	denotes	Bone
T4164	15542-15552	NN	denotes	Remodeling
T4165	15556-15565	VBN	denotes	Preserved
T4166	15553-15555	VBZ	denotes	Is
T4167	15566-15568	IN	denotes	in
T4168	15569-15573	VBN	denotes	Aged
T4169	15583-15587	NNS	denotes	Mice
T4170	15574-15579	NN	denotes	Sam68
T4171	15579-15580	SYM	denotes	−
T4172	15580-15581	HYPH	denotes	/
T4173	15581-15582	SYM	denotes	−
T4174	15587-15804	sentence	denotes	To further define the mechanisms involved in the preservation of bone mass in aged Sam68−/− mice, we prepared sections from plastic-embedded femora and tibia to evaluate osteoblast and osteoclast activity (Figure 5).
T4175	15588-15590	TO	denotes	To
T4176	15599-15605	VB	denotes	define
T4177	15591-15598	RB	denotes	further
T4178	15689-15697	VBD	denotes	prepared
T4179	15606-15609	DT	denotes	the
T4180	15610-15620	NNS	denotes	mechanisms
T4181	15621-15629	VBN	denotes	involved
T4182	15630-15632	IN	denotes	in
T4183	15633-15636	DT	denotes	the
T4184	15637-15649	NN	denotes	preservation
T4185	15650-15652	IN	denotes	of
T4186	15653-15657	NN	denotes	bone
T4187	15658-15662	NN	denotes	mass
T4188	15663-15665	IN	denotes	in
T4189	15666-15670	JJ	denotes	aged
T4190	15680-15684	NNS	denotes	mice
T4191	15671-15676	NN	denotes	Sam68
T4192	15676-15677	SYM	denotes	−
T4193	15677-15678	HYPH	denotes	/
T4194	15678-15679	SYM	denotes	−
T4195	15684-15686	,	denotes	,
T4196	15686-15688	PRP	denotes	we
T4197	15698-15706	NNS	denotes	sections
T4198	15707-15711	IN	denotes	from
T4199	15712-15719	NN	denotes	plastic
T4200	15720-15728	VBN	denotes	embedded
T4201	15719-15720	HYPH	denotes	-
T4202	15729-15735	NNS	denotes	femora
T4203	15736-15739	CC	denotes	and
T4204	15740-15745	NN	denotes	tibia
T4205	15746-15748	TO	denotes	to
T4206	15749-15757	VB	denotes	evaluate
T4207	15758-15768	NN	denotes	osteoblast
T4208	15784-15792	NN	denotes	activity
T4209	15769-15772	CC	denotes	and
T4210	15773-15783	NN	denotes	osteoclast
T4211	15793-15794	-LRB-	denotes	(
T4212	15794-15800	NN	denotes	Figure
T4213	15801-15802	CD	denotes	5
T4214	15802-15803	-RRB-	denotes	)
T4215	15803-15804	.	denotes	.
T4216	15804-16056	sentence	denotes	In situ enzyme histochemical staining for alkaline phosphatase (ALP; brown stain) activity was used as a biomarker for osteoblasts and tartrate-resistant ALP (tartrate-resistant acid phosphatase [TRAP]; red stain) activity as a marker for osteoclasts.
T4217	15805-15807	FW	denotes	In
T4218	15808-15812	FW	denotes	situ
T4219	15834-15842	NN	denotes	staining
T4220	15813-15819	NN	denotes	enzyme
T4221	15820-15833	JJ	denotes	histochemical
T4222	15900-15904	VBN	denotes	used
T4223	15843-15846	IN	denotes	for
T4224	15847-15855	NN	denotes	alkaline
T4225	15856-15867	NN	denotes	phosphatase
T4226	15887-15895	NN	denotes	activity
T4227	15868-15869	-LRB-	denotes	(
T4228	15869-15872	NN	denotes	ALP
T4229	15872-15873	:	denotes	;
T4230	15880-15885	NN	denotes	stain
T4231	15874-15879	JJ	denotes	brown
T4232	15885-15886	-RRB-	denotes	)
T4233	15896-15899	VBD	denotes	was
T4234	15905-15907	IN	denotes	as
T4235	15908-15909	DT	denotes	a
T4236	15910-15919	NN	denotes	biomarker
T4237	15920-15923	IN	denotes	for
T4238	15924-15935	NNS	denotes	osteoblasts
T4239	15936-15939	CC	denotes	and
T4240	15940-15948	NN	denotes	tartrate
T4241	15949-15958	JJ	denotes	resistant
T4242	15948-15949	HYPH	denotes	-
T4243	16019-16027	NN	denotes	activity
T4244	15959-15962	NN	denotes	ALP
T4245	15963-15964	-LRB-	denotes	(
T4246	16012-16017	NN	denotes	stain
T4247	15964-15972	NN	denotes	tartrate
T4248	15973-15982	JJ	denotes	resistant
T4249	15972-15973	HYPH	denotes	-
T4250	15988-15999	NN	denotes	phosphatase
T4251	15983-15987	NN	denotes	acid
T4252	16000-16001	-LRB-	denotes	[
T4253	16001-16005	NN	denotes	TRAP
T4254	16005-16006	-RRB-	denotes	]
T4255	16006-16007	:	denotes	;
T4256	16008-16011	JJ	denotes	red
T4257	16017-16018	-RRB-	denotes	)
T4258	16028-16030	IN	denotes	as
T4259	16031-16032	DT	denotes	a
T4260	16033-16039	NN	denotes	marker
T4261	16040-16043	IN	denotes	for
T4262	16044-16055	NNS	denotes	osteoclasts
T4263	16055-16056	.	denotes	.
T4264	16056-16176	sentence	denotes	Little difference was seen between Sam68+/+ (Figure 5A and 5B) and Sam68−/− (Figure 5C and 5D) mice at 4 months of age.
T4265	16057-16063	JJ	denotes	Little
T4266	16064-16074	NN	denotes	difference
T4267	16079-16083	VBN	denotes	seen
T4268	16075-16078	VBD	denotes	was
T4269	16084-16091	IN	denotes	between
T4270	16092-16097	NN	denotes	Sam68
T4271	16152-16156	NNS	denotes	mice
T4272	16097-16098	SYM	denotes	+
T4273	16098-16099	HYPH	denotes	/
T4274	16099-16100	SYM	denotes	+
T4275	16101-16102	-LRB-	denotes	(
T4276	16109-16111	NN	denotes	5A
T4277	16102-16108	NN	denotes	Figure
T4278	16112-16115	CC	denotes	and
T4279	16116-16118	NN	denotes	5B
T4280	16118-16119	-RRB-	denotes	)
T4281	16120-16123	CC	denotes	and
T4282	16124-16129	NN	denotes	Sam68
T4283	16129-16130	SYM	denotes	−
T4284	16130-16131	HYPH	denotes	/
T4285	16131-16132	SYM	denotes	−
T4286	16133-16134	-LRB-	denotes	(
T4287	16141-16143	NN	denotes	5C
T4288	16134-16140	NN	denotes	Figure
T4289	16144-16147	CC	denotes	and
T4290	16148-16150	NN	denotes	5D
T4291	16150-16151	-RRB-	denotes	)
T4292	16157-16159	IN	denotes	at
T4293	16160-16161	CD	denotes	4
T4294	16162-16168	NNS	denotes	months
T4295	16169-16171	IN	denotes	of
T4296	16172-16175	NN	denotes	age
T4297	16175-16176	.	denotes	.
T4298	16176-16344	sentence	denotes	ALP- and TRAP-positive cells were reduced in the 12-month-old Sam68+/+ mice (Figure 5E and 5F) and remained unchanged in 12-month-old Sam68−/− mice (Figure 5G and 5H).
T4299	16177-16180	NN	denotes	ALP
T4300	16191-16199	JJ	denotes	positive
T4301	16180-16181	HYPH	denotes	-
T4302	16182-16185	CC	denotes	and
T4303	16186-16190	NN	denotes	TRAP
T4304	16190-16191	HYPH	denotes	-
T4305	16200-16205	NNS	denotes	cells
T4306	16211-16218	VBN	denotes	reduced
T4307	16206-16210	VBD	denotes	were
T4308	16219-16221	IN	denotes	in
T4309	16222-16225	DT	denotes	the
T4310	16248-16252	NNS	denotes	mice
T4311	16226-16228	CD	denotes	12
T4312	16229-16234	NN	denotes	month
T4313	16228-16229	HYPH	denotes	-
T4314	16235-16238	JJ	denotes	old
T4315	16234-16235	HYPH	denotes	-
T4316	16239-16244	NN	denotes	Sam68
T4317	16244-16245	SYM	denotes	+
T4318	16245-16246	HYPH	denotes	/
T4319	16246-16247	SYM	denotes	+
T4320	16253-16254	-LRB-	denotes	(
T4321	16261-16263	NN	denotes	5E
T4322	16254-16260	NN	denotes	Figure
T4323	16264-16267	CC	denotes	and
T4324	16268-16270	NN	denotes	5F
T4325	16270-16271	-RRB-	denotes	)
T4326	16272-16275	CC	denotes	and
T4327	16276-16284	VBD	denotes	remained
T4328	16285-16294	JJ	denotes	unchanged
T4329	16295-16297	IN	denotes	in
T4330	16298-16300	CD	denotes	12
T4331	16301-16306	NN	denotes	month
T4332	16300-16301	HYPH	denotes	-
T4333	16307-16310	JJ	denotes	old
T4334	16306-16307	HYPH	denotes	-
T4335	16320-16324	NNS	denotes	mice
T4336	16311-16316	NN	denotes	Sam68
T4337	16316-16317	SYM	denotes	−
T4338	16317-16318	HYPH	denotes	/
T4339	16318-16319	SYM	denotes	−
T4340	16325-16326	-LRB-	denotes	(
T4341	16333-16335	NN	denotes	5G
T4342	16326-16332	NN	denotes	Figure
T4343	16336-16339	CC	denotes	and
T4344	16340-16342	NN	denotes	5H
T4345	16342-16343	-RRB-	denotes	)
T4346	16343-16344	.	denotes	.
T4347	16344-16582	sentence	denotes	The reduction in both osteoblast and osteoclast activity in the 12-month-old Sam68+/+ mice argued against bone being lost primarily due to a relative increase in osteoclast over osteoblast activity, as seen in high turnover disease [49].
T4348	16345-16348	DT	denotes	The
T4349	16349-16358	NN	denotes	reduction
T4350	16436-16442	VBD	denotes	argued
T4351	16359-16361	IN	denotes	in
T4352	16362-16366	CC	denotes	both
T4353	16367-16377	NN	denotes	osteoblast
T4354	16393-16401	NN	denotes	activity
T4355	16378-16381	CC	denotes	and
T4356	16382-16392	NN	denotes	osteoclast
T4357	16402-16404	IN	denotes	in
T4358	16405-16408	DT	denotes	the
T4359	16431-16435	NNS	denotes	mice
T4360	16409-16411	CD	denotes	12
T4361	16412-16417	NN	denotes	month
T4362	16411-16412	HYPH	denotes	-
T4363	16418-16421	JJ	denotes	old
T4364	16417-16418	HYPH	denotes	-
T4365	16422-16427	NN	denotes	Sam68
T4366	16427-16428	SYM	denotes	+
T4367	16428-16429	HYPH	denotes	/
T4368	16429-16430	SYM	denotes	+
T4369	16443-16450	IN	denotes	against
T4370	16451-16455	NN	denotes	bone
T4371	16462-16466	VBN	denotes	lost
T4372	16456-16461	VBG	denotes	being
T4373	16467-16476	RB	denotes	primarily
T4374	16477-16480	IN	denotes	due
T4375	16481-16483	IN	denotes	to
T4376	16484-16485	DT	denotes	a
T4377	16495-16503	NN	denotes	increase
T4378	16486-16494	JJ	denotes	relative
T4379	16504-16506	IN	denotes	in
T4380	16507-16517	NN	denotes	osteoclast
T4381	16518-16522	IN	denotes	over
T4382	16523-16533	NN	denotes	osteoblast
T4383	16534-16542	NN	denotes	activity
T4384	16542-16544	,	denotes	,
T4385	16544-16546	IN	denotes	as
T4386	16547-16551	VBN	denotes	seen
T4387	16552-16554	IN	denotes	in
T4388	16555-16559	JJ	denotes	high
T4389	16560-16568	NN	denotes	turnover
T4390	16569-16576	NN	denotes	disease
T4391	16577-16578	-LRB-	denotes	[
T4392	16578-16580	CD	denotes	49
T4393	16580-16581	-RRB-	denotes	]
T4394	16581-16582	.	denotes	.
T4395	16582-17336	sentence	denotes	Figure 5 Histologic Analysis of Undecalcified Bone from Sam68+/+ and Sam68−/− Mice Sections of tibia fixed in 4% paraformaldehyde and embedded in plastic were stained for ALP (A–C, E–G) activity to identify osteoblasts or for TRAP (B–D, F–H) activity to identify osteoclasts. Staining patterns were similar in 4-month-old Sam68+/+ (A and B), 4-month-old Sam68−/− (C and D), and 12-month-old Sam68−/− (G and H) mice compared with 12-month-old Sam68+/+ mice (E and F). Magnification at source, left panels ×10 and right panels ×40. Micrographs are representative of those taken from five to seven sections in each group of animals. Histomorphometric analyses [50] of the long bones (Table 3) corroborated the radiologic evidence of age-related bone loss.
T4396	17214-17231	JJ	denotes	Histomorphometric
T4397	17232-17240	NNS	denotes	analyses
T4398	17274-17286	VBD	denotes	corroborated
T4399	17241-17242	-LRB-	denotes	[
T4400	17242-17244	CD	denotes	50
T4401	17244-17245	-RRB-	denotes	]
T4402	17246-17248	IN	denotes	of
T4403	17249-17252	DT	denotes	the
T4404	17258-17263	NNS	denotes	bones
T4405	17253-17257	JJ	denotes	long
T4406	17264-17265	-LRB-	denotes	(
T4407	17265-17270	NN	denotes	Table
T4408	17271-17272	CD	denotes	3
T4409	17272-17273	-RRB-	denotes	)
T4410	17287-17290	DT	denotes	the
T4411	17302-17310	NN	denotes	evidence
T4412	17291-17301	JJ	denotes	radiologic
T4413	17311-17313	IN	denotes	of
T4414	17314-17317	NN	denotes	age
T4415	17318-17325	VBN	denotes	related
T4416	17317-17318	HYPH	denotes	-
T4417	17331-17335	NN	denotes	loss
T4418	17326-17330	NN	denotes	bone
T4419	17335-17336	.	denotes	.
T4420	17336-17523	sentence	denotes	Bone volume (BV/TV), newly formed osteoid (OV/TV), and mineral apposition rate (MAR) were all significantly reduced in 12-month-old Sam68+/+ mice compared with 4-month-old Sam68+/+ mice.
T4421	17337-17341	NN	denotes	Bone
T4422	17342-17348	NN	denotes	volume
T4423	17445-17452	VBN	denotes	reduced
T4424	17349-17350	-LRB-	denotes	(
T4425	17350-17352	NN	denotes	BV
T4426	17353-17355	NN	denotes	TV
T4427	17352-17353	HYPH	denotes	/
T4428	17355-17356	-RRB-	denotes	)
T4429	17356-17358	,	denotes	,
T4430	17358-17363	RB	denotes	newly
T4431	17364-17370	VBN	denotes	formed
T4432	17371-17378	JJ	denotes	osteoid
T4433	17379-17380	-LRB-	denotes	(
T4434	17380-17382	NN	denotes	OV
T4435	17383-17385	NN	denotes	TV
T4436	17382-17383	HYPH	denotes	/
T4437	17385-17386	-RRB-	denotes	)
T4438	17386-17388	,	denotes	,
T4439	17388-17391	CC	denotes	and
T4440	17392-17399	NN	denotes	mineral
T4441	17411-17415	NN	denotes	rate
T4442	17400-17410	NN	denotes	apposition
T4443	17416-17417	-LRB-	denotes	(
T4444	17417-17420	NN	denotes	MAR
T4445	17420-17421	-RRB-	denotes	)
T4446	17422-17426	VBD	denotes	were
T4447	17427-17430	DT	denotes	all
T4448	17431-17444	RB	denotes	significantly
T4449	17453-17455	IN	denotes	in
T4450	17456-17458	CD	denotes	12
T4451	17459-17464	NN	denotes	month
T4452	17458-17459	HYPH	denotes	-
T4453	17465-17468	JJ	denotes	old
T4454	17464-17465	HYPH	denotes	-
T4455	17478-17482	NNS	denotes	mice
T4456	17469-17474	NN	denotes	Sam68
T4457	17474-17475	SYM	denotes	+
T4458	17475-17476	HYPH	denotes	/
T4459	17476-17477	SYM	denotes	+
T4460	17483-17491	VBN	denotes	compared
T4461	17492-17496	IN	denotes	with
T4462	17497-17498	CD	denotes	4
T4463	17499-17504	NN	denotes	month
T4464	17498-17499	HYPH	denotes	-
T4465	17505-17508	JJ	denotes	old
T4466	17504-17505	HYPH	denotes	-
T4467	17518-17522	NNS	denotes	mice
T4468	17509-17514	NN	denotes	Sam68
T4469	17514-17515	SYM	denotes	+
T4470	17515-17516	HYPH	denotes	/
T4471	17516-17517	SYM	denotes	+
T4472	17522-17523	.	denotes	.
T4473	17523-17706	sentence	denotes	These reductions were associated with a significant increase in marrow fat (FV/TV) and decreased numbers of osteoblasts (nOB/TV) and osteoclasts (nOC/TV) per tissue volume (Table 3).
T4474	17524-17529	DT	denotes	These
T4475	17530-17540	NNS	denotes	reductions
T4476	17546-17556	VBN	denotes	associated
T4477	17541-17545	VBD	denotes	were
T4478	17557-17561	IN	denotes	with
T4479	17562-17563	DT	denotes	a
T4480	17576-17584	NN	denotes	increase
T4481	17564-17575	JJ	denotes	significant
T4482	17585-17587	IN	denotes	in
T4483	17588-17594	NN	denotes	marrow
T4484	17595-17598	NN	denotes	fat
T4485	17599-17600	-LRB-	denotes	(
T4486	17603-17605	NN	denotes	TV
T4487	17600-17602	NN	denotes	FV
T4488	17602-17603	HYPH	denotes	/
T4489	17605-17606	-RRB-	denotes	)
T4490	17607-17610	CC	denotes	and
T4491	17611-17620	VBN	denotes	decreased
T4492	17621-17628	NNS	denotes	numbers
T4493	17629-17631	IN	denotes	of
T4494	17632-17643	NNS	denotes	osteoblasts
T4495	17644-17645	-LRB-	denotes	(
T4496	17649-17651	NN	denotes	TV
T4497	17645-17648	NN	denotes	nOB
T4498	17648-17649	HYPH	denotes	/
T4499	17651-17652	-RRB-	denotes	)
T4500	17653-17656	CC	denotes	and
T4501	17657-17668	NNS	denotes	osteoclasts
T4502	17669-17670	-LRB-	denotes	(
T4503	17674-17676	NN	denotes	TV
T4504	17670-17673	NN	denotes	nOC
T4505	17673-17674	HYPH	denotes	/
T4506	17676-17677	-RRB-	denotes	)
T4507	17678-17681	IN	denotes	per
T4508	17682-17688	NN	denotes	tissue
T4509	17689-17695	NN	denotes	volume
T4510	17696-17697	-LRB-	denotes	(
T4511	17697-17702	NN	denotes	Table
T4512	17703-17704	CD	denotes	3
T4513	17704-17705	-RRB-	denotes	)
T4514	17705-17706	.	denotes	.
T4515	17706-17905	sentence	denotes	These results were in contrast to those of the 12-month-old Sam68−/− mice in which all histomorphometric parameters, including marrow fat, resembled those of young mice of either genotype (Table 3).
T4516	17707-17712	DT	denotes	These
T4517	17713-17720	NNS	denotes	results
T4518	17721-17725	VBD	denotes	were
T4519	17726-17728	IN	denotes	in
T4520	17729-17737	NN	denotes	contrast
T4521	17738-17740	IN	denotes	to
T4522	17741-17746	DT	denotes	those
T4523	17747-17749	IN	denotes	of
T4524	17750-17753	DT	denotes	the
T4525	17776-17780	NNS	denotes	mice
T4526	17754-17756	CD	denotes	12
T4527	17757-17762	NN	denotes	month
T4528	17756-17757	HYPH	denotes	-
T4529	17763-17766	JJ	denotes	old
T4530	17762-17763	HYPH	denotes	-
T4531	17767-17772	NN	denotes	Sam68
T4532	17772-17773	SYM	denotes	−
T4533	17773-17774	HYPH	denotes	/
T4534	17774-17775	SYM	denotes	−
T4535	17781-17783	IN	denotes	in
T4536	17846-17855	VBD	denotes	resembled
T4537	17784-17789	WDT	denotes	which
T4538	17790-17793	DT	denotes	all
T4539	17812-17822	NNS	denotes	parameters
T4540	17794-17811	JJ	denotes	histomorphometric
T4541	17822-17824	,	denotes	,
T4542	17824-17833	VBG	denotes	including
T4543	17834-17840	NN	denotes	marrow
T4544	17841-17844	NN	denotes	fat
T4545	17844-17846	,	denotes	,
T4546	17856-17861	DT	denotes	those
T4547	17862-17864	IN	denotes	of
T4548	17865-17870	JJ	denotes	young
T4549	17871-17875	NNS	denotes	mice
T4550	17876-17878	IN	denotes	of
T4551	17879-17885	CC	denotes	either
T4552	17886-17894	NN	denotes	genotype
T4553	17895-17896	-LRB-	denotes	(
T4554	17896-17901	NN	denotes	Table
T4555	17902-17903	CD	denotes	3
T4556	17903-17904	-RRB-	denotes	)
T4557	17904-17905	.	denotes	.
T4558	17905-18112	sentence	denotes	When cells were expressed as a function of the bone perimeter (nOB/BP, nOC/BP), there were no statistical differences and the ratio of osteoblasts to osteoclasts was similar in all groups of mice (Table 3).
T4559	17906-17910	WRB	denotes	When
T4560	17922-17931	VBN	denotes	expressed
T4561	17911-17916	NNS	denotes	cells
T4562	17917-17921	VBD	denotes	were
T4563	17992-17996	VBD	denotes	were
T4564	17932-17934	IN	denotes	as
T4565	17935-17936	DT	denotes	a
T4566	17937-17945	NN	denotes	function
T4567	17946-17948	IN	denotes	of
T4568	17949-17952	DT	denotes	the
T4569	17958-17967	NN	denotes	perimeter
T4570	17953-17957	NN	denotes	bone
T4571	17968-17969	-LRB-	denotes	(
T4572	17973-17975	NN	denotes	BP
T4573	17969-17972	NN	denotes	nOB
T4574	17972-17973	HYPH	denotes	/
T4575	17975-17977	,	denotes	,
T4576	17977-17980	NN	denotes	nOC
T4577	17981-17983	NN	denotes	BP
T4578	17980-17981	HYPH	denotes	/
T4579	17983-17984	-RRB-	denotes	)
T4580	17984-17986	,	denotes	,
T4581	17986-17991	EX	denotes	there
T4582	17997-17999	DT	denotes	no
T4583	18012-18023	NNS	denotes	differences
T4584	18000-18011	JJ	denotes	statistical
T4585	18024-18027	CC	denotes	and
T4586	18028-18031	DT	denotes	the
T4587	18032-18037	NN	denotes	ratio
T4588	18068-18071	VBD	denotes	was
T4589	18038-18040	IN	denotes	of
T4590	18041-18052	NNS	denotes	osteoblasts
T4591	18053-18055	IN	denotes	to
T4592	18056-18067	NNS	denotes	osteoclasts
T4593	18072-18079	JJ	denotes	similar
T4594	18080-18082	IN	denotes	in
T4595	18083-18086	DT	denotes	all
T4596	18087-18093	NNS	denotes	groups
T4597	18094-18096	IN	denotes	of
T4598	18097-18101	NNS	denotes	mice
T4599	18102-18103	-LRB-	denotes	(
T4600	18103-18108	NN	denotes	Table
T4601	18109-18110	CD	denotes	3
T4602	18110-18111	-RRB-	denotes	)
T4603	18111-18112	.	denotes	.
T4604	18112-18406	sentence	denotes	Table 3 Histomorphometric Analysis of Long Bones from 4- and 12-Month-Old Mice Circulating levels of serum C-telopeptide (sCTX; Roche Diagnostics, Mannheim, Germany) and ALP showed little difference among the groups, except for a small decrease in 12-month-old Sam68−/− mice and (Dataset S3).
T4605	18193-18204	VBG	denotes	Circulating
T4606	18205-18211	NNS	denotes	levels
T4607	18288-18294	VBD	denotes	showed
T4608	18212-18214	IN	denotes	of
T4609	18215-18220	NN	denotes	serum
T4610	18223-18234	NN	denotes	telopeptide
T4611	18221-18222	NN	denotes	C
T4612	18222-18223	HYPH	denotes	-
T4613	18235-18236	-LRB-	denotes	(
T4614	18248-18259	NNP	denotes	Diagnostics
T4615	18236-18240	NN	denotes	sCTX
T4616	18240-18241	:	denotes	;
T4617	18242-18247	NNP	denotes	Roche
T4618	18259-18261	,	denotes	,
T4619	18261-18269	NNP	denotes	Mannheim
T4620	18269-18271	,	denotes	,
T4621	18271-18278	NNP	denotes	Germany
T4622	18278-18279	-RRB-	denotes	)
T4623	18280-18283	CC	denotes	and
T4624	18284-18287	NN	denotes	ALP
T4625	18295-18301	JJ	denotes	little
T4626	18302-18312	NN	denotes	difference
T4627	18313-18318	IN	denotes	among
T4628	18319-18322	DT	denotes	the
T4629	18323-18329	NNS	denotes	groups
T4630	18329-18331	,	denotes	,
T4631	18331-18337	IN	denotes	except
T4632	18338-18341	IN	denotes	for
T4633	18342-18343	DT	denotes	a
T4634	18350-18358	NN	denotes	decrease
T4635	18344-18349	JJ	denotes	small
T4636	18359-18361	IN	denotes	in
T4637	18362-18364	CD	denotes	12
T4638	18365-18370	NN	denotes	month
T4639	18364-18365	HYPH	denotes	-
T4640	18371-18374	JJ	denotes	old
T4641	18370-18371	HYPH	denotes	-
T4642	18384-18388	NNS	denotes	mice
T4643	18375-18380	NN	denotes	Sam68
T4644	18380-18381	SYM	denotes	−
T4645	18381-18382	HYPH	denotes	/
T4646	18382-18383	SYM	denotes	−
T4647	18389-18392	CC	denotes	and
T4648	18393-18394	-LRB-	denotes	(
T4649	18402-18404	NN	denotes	S3
T4650	18394-18401	NN	denotes	Dataset
T4651	18404-18405	-RRB-	denotes	)
T4652	18405-18406	.	denotes	.
T4653	18406-18562	sentence	denotes	Serum estrogen was significantly decreased in all 12-month-old mice regardless of genotype with a reciprocal increase in interleukin-6 levels (Dataset S3).
T4654	18407-18412	NN	denotes	Serum
T4655	18413-18421	NN	denotes	estrogen
T4656	18440-18449	VBN	denotes	decreased
T4657	18422-18425	VBD	denotes	was
T4658	18426-18439	RB	denotes	significantly
T4659	18450-18452	IN	denotes	in
T4660	18453-18456	DT	denotes	all
T4661	18470-18474	NNS	denotes	mice
T4662	18457-18459	CD	denotes	12
T4663	18460-18465	NN	denotes	month
T4664	18459-18460	HYPH	denotes	-
T4665	18466-18469	JJ	denotes	old
T4666	18465-18466	HYPH	denotes	-
T4667	18475-18485	RB	denotes	regardless
T4668	18486-18488	IN	denotes	of
T4669	18489-18497	NN	denotes	genotype
T4670	18498-18502	IN	denotes	with
T4671	18503-18504	DT	denotes	a
T4672	18516-18524	NN	denotes	increase
T4673	18505-18515	JJ	denotes	reciprocal
T4674	18525-18527	IN	denotes	in
T4675	18528-18539	NN	denotes	interleukin
T4676	18542-18548	NNS	denotes	levels
T4677	18539-18540	HYPH	denotes	-
T4678	18540-18541	CD	denotes	6
T4679	18549-18550	-LRB-	denotes	(
T4680	18558-18560	NN	denotes	S3
T4681	18550-18557	NN	denotes	Dataset
T4682	18560-18561	-RRB-	denotes	)
T4683	18561-18562	.	denotes	.
T4684	18562-18685	sentence	denotes	Given the involvement of leptin in regulating body and bone mass, serum leptin was measured in Sam68+/+ and Sam68−/− mice.
T4685	18563-18568	VBN	denotes	Given
T4686	18646-18654	VBN	denotes	measured
T4687	18569-18572	DT	denotes	the
T4688	18573-18584	NN	denotes	involvement
T4689	18585-18587	IN	denotes	of
T4690	18588-18594	NN	denotes	leptin
T4691	18595-18597	IN	denotes	in
T4692	18598-18608	VBG	denotes	regulating
T4693	18609-18613	NN	denotes	body
T4694	18623-18627	NN	denotes	mass
T4695	18614-18617	CC	denotes	and
T4696	18618-18622	NN	denotes	bone
T4697	18627-18629	,	denotes	,
T4698	18629-18634	NN	denotes	serum
T4699	18635-18641	NN	denotes	leptin
T4700	18642-18645	VBD	denotes	was
T4701	18655-18657	IN	denotes	in
T4702	18658-18663	NN	denotes	Sam68
T4703	18680-18684	NNS	denotes	mice
T4704	18663-18664	SYM	denotes	+
T4705	18664-18665	HYPH	denotes	/
T4706	18665-18666	SYM	denotes	+
T4707	18667-18670	CC	denotes	and
T4708	18671-18676	NN	denotes	Sam68
T4709	18676-18677	SYM	denotes	−
T4710	18677-18678	HYPH	denotes	/
T4711	18678-18679	SYM	denotes	−
T4712	18684-18685	.	denotes	.
T4713	18685-18818	sentence	denotes	Twelve-month-old Sam68−/− mice had significantly lower levels than young and old Sam68+/+ mice and young Sam68−/− mice (Dataset S3).
T4714	18686-18692	CD	denotes	Twelve
T4715	18693-18698	NN	denotes	month
T4716	18692-18693	HYPH	denotes	-
T4717	18699-18702	JJ	denotes	old
T4718	18698-18699	HYPH	denotes	-
T4719	18712-18716	NNS	denotes	mice
T4720	18703-18708	NN	denotes	Sam68
T4721	18708-18709	SYM	denotes	−
T4722	18709-18710	HYPH	denotes	/
T4723	18710-18711	SYM	denotes	−
T4724	18717-18720	VBD	denotes	had
T4725	18721-18734	RB	denotes	significantly
T4726	18735-18740	JJR	denotes	lower
T4727	18741-18747	NNS	denotes	levels
T4728	18748-18752	IN	denotes	than
T4729	18753-18758	JJ	denotes	young
T4730	18776-18780	NNS	denotes	mice
T4731	18759-18762	CC	denotes	and
T4732	18763-18766	JJ	denotes	old
T4733	18767-18772	NN	denotes	Sam68
T4734	18772-18773	SYM	denotes	+
T4735	18773-18774	HYPH	denotes	/
T4736	18774-18775	SYM	denotes	+
T4737	18781-18784	CC	denotes	and
T4738	18785-18790	JJ	denotes	young
T4739	18800-18804	NNS	denotes	mice
T4740	18791-18796	NN	denotes	Sam68
T4741	18796-18797	SYM	denotes	−
T4742	18797-18798	HYPH	denotes	/
T4743	18798-18799	SYM	denotes	−
T4744	18805-18806	-LRB-	denotes	(
T4745	18814-18816	NN	denotes	S3
T4746	18806-18813	NN	denotes	Dataset
T4747	18816-18817	-RRB-	denotes	)
T4748	18817-18818	.	denotes	.
T4749	18818-19040	sentence	denotes	Taken together, these observations suggested that preservation of bone mass in the Sam68−/− mice was not due primarily to altered estrogen status but could have been influenced by differences in circulating leptin levels.
T4750	18819-18824	VBN	denotes	Taken
T4751	18854-18863	VBD	denotes	suggested
T4752	18825-18833	RB	denotes	together
T4753	18833-18835	,	denotes	,
T4754	18835-18840	DT	denotes	these
T4755	18841-18853	NNS	denotes	observations
T4756	18864-18868	IN	denotes	that
T4757	18916-18919	VBD	denotes	was
T4758	18869-18881	NN	denotes	preservation
T4759	18882-18884	IN	denotes	of
T4760	18885-18889	NN	denotes	bone
T4761	18890-18894	NN	denotes	mass
T4762	18895-18897	IN	denotes	in
T4763	18898-18901	DT	denotes	the
T4764	18911-18915	NNS	denotes	mice
T4765	18902-18907	NN	denotes	Sam68
T4766	18907-18908	SYM	denotes	−
T4767	18908-18909	HYPH	denotes	/
T4768	18909-18910	SYM	denotes	−
T4769	18920-18923	RB	denotes	not
T4770	18924-18927	IN	denotes	due
T4771	18928-18937	RB	denotes	primarily
T4772	18938-18940	IN	denotes	to
T4773	18941-18948	VBN	denotes	altered
T4774	18958-18964	NN	denotes	status
T4775	18949-18957	NN	denotes	estrogen
T4776	18965-18968	CC	denotes	but
T4777	18969-18974	MD	denotes	could
T4778	18985-18995	VBN	denotes	influenced
T4779	18975-18979	VB	denotes	have
T4780	18980-18984	VBN	denotes	been
T4781	18996-18998	IN	denotes	by
T4782	18999-19010	NNS	denotes	differences
T4783	19011-19013	IN	denotes	in
T4784	19014-19025	VBG	denotes	circulating
T4785	19033-19039	NNS	denotes	levels
T4786	19026-19032	NN	denotes	leptin
T4787	19039-19040	.	denotes	.
T4956	19042-19052	NN	denotes	Osteoblast
T4957	19074-19082	NN	denotes	Activity
T4958	19052-19054	,	denotes	,
T4959	19054-19057	CC	denotes	but
T4960	19058-19061	RB	denotes	Not
T4961	19062-19072	NN	denotes	Osteoclast
T4962	19072-19074	,	denotes	,
T4963	19086-19093	VBN	denotes	Altered
T4964	19083-19085	VBZ	denotes	Is
T4965	19094-19096	IN	denotes	in
T4966	19097-19102	NN	denotes	Sam68
T4967	19106-19110	NNS	denotes	Mice
T4968	19102-19103	SYM	denotes	−
T4969	19103-19104	HYPH	denotes	/
T4970	19104-19105	SYM	denotes	−
T4971	19111-19113	FW	denotes	Ex
T4972	19114-19118	FW	denotes	Vivo
T4973	19118-19297	sentence	denotes	Maintenance of bone mass during the adult remodeling cycle is dependent on the coupling of osteoblast to osteoclast activity, such that there is no net gain or loss of bone [49].
T4974	19119-19130	NN	denotes	Maintenance
T4975	19178-19180	VBZ	denotes	is
T4976	19131-19133	IN	denotes	of
T4977	19134-19138	NN	denotes	bone
T4978	19139-19143	NN	denotes	mass
T4979	19144-19150	IN	denotes	during
T4980	19151-19154	DT	denotes	the
T4981	19172-19177	NN	denotes	cycle
T4982	19155-19160	JJ	denotes	adult
T4983	19161-19171	NN	denotes	remodeling
T4984	19181-19190	JJ	denotes	dependent
T4985	19191-19193	IN	denotes	on
T4986	19194-19197	DT	denotes	the
T4987	19198-19206	NN	denotes	coupling
T4988	19207-19209	IN	denotes	of
T4989	19210-19220	NN	denotes	osteoblast
T4990	19221-19223	IN	denotes	to
T4991	19224-19234	NN	denotes	osteoclast
T4992	19235-19243	NN	denotes	activity
T4993	19243-19245	,	denotes	,
T4994	19245-19249	JJ	denotes	such
T4995	19261-19263	VBZ	denotes	is
T4996	19250-19254	IN	denotes	that
T4997	19255-19260	EX	denotes	there
T4998	19264-19266	DT	denotes	no
T4999	19271-19275	NN	denotes	gain
T5000	19267-19270	JJ	denotes	net
T5001	19276-19278	CC	denotes	or
T5002	19279-19283	NN	denotes	loss
T5003	19284-19286	IN	denotes	of
T5004	19287-19291	NN	denotes	bone
T5005	19292-19293	-LRB-	denotes	[
T5006	19293-19295	CD	denotes	49
T5007	19295-19296	-RRB-	denotes	]
T5008	19296-19297	.	denotes	.
T5009	19297-19498	sentence	denotes	To further explore the age-related advantage of Sam68−/− mice with respect to bone preservation, we examined the functional activity of Sam68−/− osteoblasts and osteoclasts ex vivo (Figure 6A and 6B).
T5010	19298-19300	TO	denotes	To
T5011	19309-19316	VB	denotes	explore
T5012	19301-19308	RB	denotes	further
T5013	19398-19406	VBD	denotes	examined
T5014	19317-19320	DT	denotes	the
T5015	19333-19342	NN	denotes	advantage
T5016	19321-19324	NN	denotes	age
T5017	19325-19332	VBN	denotes	related
T5018	19324-19325	HYPH	denotes	-
T5019	19343-19345	IN	denotes	of
T5020	19346-19351	NN	denotes	Sam68
T5021	19355-19359	NNS	denotes	mice
T5022	19351-19352	SYM	denotes	−
T5023	19352-19353	HYPH	denotes	/
T5024	19353-19354	SYM	denotes	−
T5025	19360-19364	IN	denotes	with
T5026	19365-19372	NN	denotes	respect
T5027	19373-19375	IN	denotes	to
T5028	19376-19380	NN	denotes	bone
T5029	19381-19393	NN	denotes	preservation
T5030	19393-19395	,	denotes	,
T5031	19395-19397	PRP	denotes	we
T5032	19407-19410	DT	denotes	the
T5033	19422-19430	NN	denotes	activity
T5034	19411-19421	JJ	denotes	functional
T5035	19431-19433	IN	denotes	of
T5036	19434-19439	NN	denotes	Sam68
T5037	19439-19440	SYM	denotes	−
T5038	19440-19441	HYPH	denotes	/
T5039	19441-19442	SYM	denotes	−
T5040	19443-19454	NNS	denotes	osteoblasts
T5041	19455-19458	CC	denotes	and
T5042	19459-19470	NNS	denotes	osteoclasts
T5043	19471-19473	FW	denotes	ex
T5044	19474-19478	FW	denotes	vivo
T5045	19479-19480	-LRB-	denotes	(
T5046	19487-19489	NN	denotes	6A
T5047	19480-19486	NN	denotes	Figure
T5048	19490-19493	CC	denotes	and
T5049	19494-19496	NN	denotes	6B
T5050	19496-19497	-RRB-	denotes	)
T5051	19497-19498	.	denotes	.
T5052	19498-19921	sentence	denotes	Cultures of bone marrow stromal cells harvested from 4-week-old Sam68−/− mice and maintained for 18 days in osteoblast differentiation medium demonstrated more intense staining for ALP at 6 days (unpublished data) and 18 days (Figure 6A), and more mineralized nodules at 18 days, than the Sam68+/+ mice, even though similar amounts of fibroblast colony-forming units (CFU-F) were observed (Figure 6A and unpublished data).
T5053	19499-19507	NNS	denotes	Cultures
T5054	19641-19653	VBD	denotes	demonstrated
T5055	19508-19510	IN	denotes	of
T5056	19511-19515	NN	denotes	bone
T5057	19516-19522	NN	denotes	marrow
T5058	19531-19536	NNS	denotes	cells
T5059	19523-19530	JJ	denotes	stromal
T5060	19537-19546	VBN	denotes	harvested
T5061	19547-19551	IN	denotes	from
T5062	19552-19553	CD	denotes	4
T5063	19554-19558	NN	denotes	week
T5064	19553-19554	HYPH	denotes	-
T5065	19559-19562	JJ	denotes	old
T5066	19558-19559	HYPH	denotes	-
T5067	19572-19576	NNS	denotes	mice
T5068	19563-19568	NN	denotes	Sam68
T5069	19568-19569	SYM	denotes	−
T5070	19569-19570	HYPH	denotes	/
T5071	19570-19571	SYM	denotes	−
T5072	19577-19580	CC	denotes	and
T5073	19581-19591	VBN	denotes	maintained
T5074	19592-19595	IN	denotes	for
T5075	19596-19598	CD	denotes	18
T5076	19599-19603	NNS	denotes	days
T5077	19604-19606	IN	denotes	in
T5078	19607-19617	NN	denotes	osteoblast
T5079	19618-19633	NN	denotes	differentiation
T5080	19634-19640	NN	denotes	medium
T5081	19654-19658	RBR	denotes	more
T5082	19659-19666	JJ	denotes	intense
T5083	19667-19675	NN	denotes	staining
T5084	19676-19679	IN	denotes	for
T5085	19680-19683	NN	denotes	ALP
T5086	19684-19686	IN	denotes	at
T5087	19687-19688	CD	denotes	6
T5088	19689-19693	NNS	denotes	days
T5089	19694-19695	-LRB-	denotes	(
T5090	19707-19711	NNS	denotes	data
T5091	19695-19706	JJ	denotes	unpublished
T5092	19711-19712	-RRB-	denotes	)
T5093	19713-19716	CC	denotes	and
T5094	19717-19719	CD	denotes	18
T5095	19720-19724	NNS	denotes	days
T5096	19725-19726	-LRB-	denotes	(
T5097	19733-19735	NN	denotes	6A
T5098	19726-19732	NN	denotes	Figure
T5099	19735-19736	NN	denotes	)
T5100	19736-19738	NN	denotes	,
T5101	19738-19741	CC	denotes	and
T5102	19742-19746	JJR	denotes	more
T5103	19759-19766	NNS	denotes	nodules
T5104	19747-19758	VBN	denotes	mineralized
T5105	19767-19769	IN	denotes	at
T5106	19770-19772	CD	denotes	18
T5107	19773-19777	NNS	denotes	days
T5108	19777-19779	NN	denotes	,
T5109	19779-19783	IN	denotes	than
T5110	19784-19787	DT	denotes	the
T5111	19797-19801	NNS	denotes	mice
T5112	19788-19793	NN	denotes	Sam68
T5113	19793-19794	SYM	denotes	+
T5114	19794-19795	HYPH	denotes	/
T5115	19795-19796	SYM	denotes	+
T5116	19801-19803	NN	denotes	,
T5117	19803-19807	RB	denotes	even
T5118	19879-19887	VBN	denotes	observed
T5119	19808-19814	IN	denotes	though
T5120	19815-19822	JJ	denotes	similar
T5121	19823-19830	NNS	denotes	amounts
T5122	19831-19833	IN	denotes	of
T5123	19834-19844	NN	denotes	fibroblast
T5124	19860-19865	NNS	denotes	units
T5125	19845-19851	NN	denotes	colony
T5126	19852-19859	VBG	denotes	forming
T5127	19851-19852	HYPH	denotes	-
T5128	19866-19867	-LRB-	denotes	(
T5129	19867-19870	NN	denotes	CFU
T5130	19871-19872	NN	denotes	F
T5131	19870-19871	HYPH	denotes	-
T5132	19872-19873	-RRB-	denotes	)
T5133	19874-19878	VBD	denotes	were
T5134	19888-19889	-LRB-	denotes	(
T5135	19896-19898	NN	denotes	6A
T5136	19889-19895	NN	denotes	Figure
T5137	19899-19902	CC	denotes	and
T5138	19903-19914	JJ	denotes	unpublished
T5139	19915-19919	NNS	denotes	data
T5140	19919-19920	-RRB-	denotes	)
T5141	19920-19921	.	denotes	.
T5142	19921-20172	sentence	denotes	RT-PCR analysis of molecular markers of osteoblast differentiation (Dataset S2) revealed similar increases over time in RNA from Sam68+/+ and Sam68−/− mice, although type I collagen appeared to be up-regulated at both timepoints in the Sam68−/− mice.
T5143	19922-19924	NN	denotes	RT
T5144	19925-19928	NN	denotes	PCR
T5145	19924-19925	HYPH	denotes	-
T5146	19929-19937	NN	denotes	analysis
T5147	20002-20010	VBD	denotes	revealed
T5148	19938-19940	IN	denotes	of
T5149	19941-19950	JJ	denotes	molecular
T5150	19951-19958	NNS	denotes	markers
T5151	19959-19961	IN	denotes	of
T5152	19962-19972	NN	denotes	osteoblast
T5153	19973-19988	NN	denotes	differentiation
T5154	19989-19990	-LRB-	denotes	(
T5155	19998-20000	NN	denotes	S2
T5156	19990-19997	NN	denotes	Dataset
T5157	20000-20001	-RRB-	denotes	)
T5158	20011-20018	JJ	denotes	similar
T5159	20019-20028	NNS	denotes	increases
T5160	20029-20033	IN	denotes	over
T5161	20034-20038	NN	denotes	time
T5162	20039-20041	IN	denotes	in
T5163	20042-20045	NN	denotes	RNA
T5164	20046-20050	IN	denotes	from
T5165	20051-20056	NN	denotes	Sam68
T5166	20073-20077	NNS	denotes	mice
T5167	20056-20057	SYM	denotes	+
T5168	20057-20058	HYPH	denotes	/
T5169	20058-20059	SYM	denotes	+
T5170	20060-20063	CC	denotes	and
T5171	20064-20069	NN	denotes	Sam68
T5172	20069-20070	SYM	denotes	−
T5173	20070-20071	HYPH	denotes	/
T5174	20071-20072	SYM	denotes	−
T5175	20077-20079	,	denotes	,
T5176	20079-20087	IN	denotes	although
T5177	20104-20112	VBD	denotes	appeared
T5178	20088-20092	NN	denotes	type
T5179	20095-20103	NN	denotes	collagen
T5180	20093-20094	CD	denotes	I
T5181	20113-20115	TO	denotes	to
T5182	20122-20131	VBN	denotes	regulated
T5183	20116-20118	VB	denotes	be
T5184	20119-20121	RB	denotes	up
T5185	20121-20122	HYPH	denotes	-
T5186	20132-20134	IN	denotes	at
T5187	20135-20139	DT	denotes	both
T5188	20140-20150	NNS	denotes	timepoints
T5189	20151-20153	IN	denotes	in
T5190	20154-20157	DT	denotes	the
T5191	20167-20171	NNS	denotes	mice
T5192	20158-20163	NN	denotes	Sam68
T5193	20163-20164	SYM	denotes	−
T5194	20164-20165	HYPH	denotes	/
T5195	20165-20166	SYM	denotes	−
T5196	20171-20172	.	denotes	.
T5197	20172-20452	sentence	denotes	Short-term cultures of mature osteoclasts released from the crushed long bones of Sam68+/+ and Sam68−/− mice stained equally well for TRAP and excavated approximately equal numbers of pits of equal size in dentin slices, as visualized by scanning electron microscopy (Figure 6B).
T5198	20173-20178	JJ	denotes	Short
T5199	20179-20183	NN	denotes	term
T5200	20178-20179	HYPH	denotes	-
T5201	20184-20192	NNS	denotes	cultures
T5202	20282-20289	VBD	denotes	stained
T5203	20193-20195	IN	denotes	of
T5204	20196-20202	JJ	denotes	mature
T5205	20203-20214	NNS	denotes	osteoclasts
T5206	20215-20223	VBN	denotes	released
T5207	20224-20228	IN	denotes	from
T5208	20229-20232	DT	denotes	the
T5209	20246-20251	NNS	denotes	bones
T5210	20233-20240	JJ	denotes	crushed
T5211	20241-20245	JJ	denotes	long
T5212	20252-20254	IN	denotes	of
T5213	20255-20260	NN	denotes	Sam68
T5214	20277-20281	NNS	denotes	mice
T5215	20260-20261	SYM	denotes	+
T5216	20261-20262	HYPH	denotes	/
T5217	20262-20263	SYM	denotes	+
T5218	20264-20267	CC	denotes	and
T5219	20268-20273	NN	denotes	Sam68
T5220	20273-20274	SYM	denotes	−
T5221	20274-20275	HYPH	denotes	/
T5222	20275-20276	SYM	denotes	−
T5223	20290-20297	RB	denotes	equally
T5224	20298-20302	RB	denotes	well
T5225	20303-20306	IN	denotes	for
T5226	20307-20311	NN	denotes	TRAP
T5227	20312-20315	CC	denotes	and
T5228	20316-20325	VBD	denotes	excavated
T5229	20326-20339	RB	denotes	approximately
T5230	20340-20345	JJ	denotes	equal
T5231	20346-20353	NNS	denotes	numbers
T5232	20354-20356	IN	denotes	of
T5233	20357-20361	NNS	denotes	pits
T5234	20362-20364	IN	denotes	of
T5235	20365-20370	JJ	denotes	equal
T5236	20371-20375	NN	denotes	size
T5237	20376-20378	IN	denotes	in
T5238	20379-20385	NN	denotes	dentin
T5239	20386-20392	NNS	denotes	slices
T5240	20392-20394	,	denotes	,
T5241	20394-20396	IN	denotes	as
T5242	20397-20407	VBN	denotes	visualized
T5243	20408-20410	IN	denotes	by
T5244	20411-20419	VBG	denotes	scanning
T5245	20420-20428	NN	denotes	electron
T5246	20429-20439	NN	denotes	microscopy
T5247	20440-20441	-LRB-	denotes	(
T5248	20448-20450	NN	denotes	6B
T5249	20441-20447	NN	denotes	Figure
T5250	20450-20451	-RRB-	denotes	)
T5251	20451-20452	.	denotes	.
T5252	20452-20579	sentence	denotes	These findings suggest that the osteoclasts may not be the primary defect in Sam68−/− mice, as they are in Src null mice [48].
T5253	20453-20458	DT	denotes	These
T5254	20459-20467	NNS	denotes	findings
T5255	20468-20475	VBP	denotes	suggest
T5256	20476-20480	IN	denotes	that
T5257	20505-20507	VB	denotes	be
T5258	20481-20484	DT	denotes	the
T5259	20485-20496	NNS	denotes	osteoclasts
T5260	20497-20500	MD	denotes	may
T5261	20501-20504	RB	denotes	not
T5262	20508-20511	DT	denotes	the
T5263	20520-20526	NN	denotes	defect
T5264	20512-20519	JJ	denotes	primary
T5265	20527-20529	IN	denotes	in
T5266	20530-20535	NN	denotes	Sam68
T5267	20539-20543	NNS	denotes	mice
T5268	20535-20536	SYM	denotes	−
T5269	20536-20537	HYPH	denotes	/
T5270	20537-20538	SYM	denotes	−
T5271	20543-20545	,	denotes	,
T5272	20545-20547	IN	denotes	as
T5273	20553-20556	VBP	denotes	are
T5274	20548-20552	PRP	denotes	they
T5275	20557-20559	IN	denotes	in
T5276	20560-20563	NN	denotes	Src
T5277	20569-20573	NNS	denotes	mice
T5278	20564-20568	JJ	denotes	null
T5279	20574-20575	-LRB-	denotes	[
T5280	20575-20577	CD	denotes	48
T5281	20577-20578	-RRB-	denotes	]
T5282	20578-20579	.	denotes	.
T5689	21645-21648	DT	denotes	The
T5690	21649-21656	NN	denotes	Absence
T5691	21666-21674	VBZ	denotes	Prevents
T5692	21657-21659	IN	denotes	of
T5693	21660-21665	NN	denotes	Sam68
T5694	21675-21684	NN	denotes	Adipocyte
T5695	21685-21700	NN	denotes	Differentiation
T5696	21701-21704	CC	denotes	and
T5697	21705-21713	VBZ	denotes	Promotes
T5698	21714-21724	NN	denotes	Osteoblast
T5699	21725-21740	NN	denotes	Differentiation
T5700	21740-21951	sentence	denotes	It is well recognized that bone marrow stromal cells give rise to both osteoblasts and adipocytes and that age-related bone loss is accompanied by an increase in differentiation down the adipocyte lineage [22].
T5701	21741-21743	PRP	denotes	It
T5702	21752-21762	VBN	denotes	recognized
T5703	21744-21746	VBZ	denotes	is
T5704	21747-21751	RB	denotes	well
T5705	21763-21767	IN	denotes	that
T5706	21794-21798	VBP	denotes	give
T5707	21768-21772	NN	denotes	bone
T5708	21773-21779	NN	denotes	marrow
T5709	21788-21793	NNS	denotes	cells
T5710	21780-21787	JJ	denotes	stromal
T5711	21799-21803	NN	denotes	rise
T5712	21804-21806	IN	denotes	to
T5713	21807-21811	DT	denotes	both
T5714	21812-21823	NNS	denotes	osteoblasts
T5715	21824-21827	CC	denotes	and
T5716	21828-21838	NNS	denotes	adipocytes
T5717	21839-21842	CC	denotes	and
T5718	21843-21847	IN	denotes	that
T5719	21873-21884	VBN	denotes	accompanied
T5720	21848-21851	NN	denotes	age
T5721	21852-21859	VBN	denotes	related
T5722	21851-21852	HYPH	denotes	-
T5723	21865-21869	NN	denotes	loss
T5724	21860-21864	NN	denotes	bone
T5725	21870-21872	VBZ	denotes	is
T5726	21885-21887	IN	denotes	by
T5727	21888-21890	DT	denotes	an
T5728	21891-21899	NN	denotes	increase
T5729	21900-21902	IN	denotes	in
T5730	21903-21918	NN	denotes	differentiation
T5731	21919-21923	IN	denotes	down
T5732	21924-21927	DT	denotes	the
T5733	21938-21945	NN	denotes	lineage
T5734	21928-21937	NN	denotes	adipocyte
T5735	21946-21947	-LRB-	denotes	[
T5736	21947-21949	CD	denotes	22
T5737	21949-21950	-RRB-	denotes	]
T5738	21950-21951	.	denotes	.
T5739	21951-22095	sentence	denotes	Therefore, the loss of Sam68 could influence the bone marrow stromal cells to differentiate along the osteogenic versus the adipogenic pathway.
T5740	21952-21961	RB	denotes	Therefore
T5741	21987-21996	VB	denotes	influence
T5742	21961-21963	,	denotes	,
T5743	21963-21966	DT	denotes	the
T5744	21967-21971	NN	denotes	loss
T5745	21972-21974	IN	denotes	of
T5746	21975-21980	NN	denotes	Sam68
T5747	21981-21986	MD	denotes	could
T5748	21997-22000	DT	denotes	the
T5749	22021-22026	NNS	denotes	cells
T5750	22001-22005	NN	denotes	bone
T5751	22006-22012	NN	denotes	marrow
T5752	22013-22020	JJ	denotes	stromal
T5753	22027-22029	TO	denotes	to
T5754	22030-22043	VB	denotes	differentiate
T5755	22044-22049	IN	denotes	along
T5756	22050-22053	DT	denotes	the
T5757	22054-22064	JJ	denotes	osteogenic
T5758	22065-22071	CC	denotes	versus
T5759	22072-22075	DT	denotes	the
T5760	22076-22086	JJ	denotes	adipogenic
T5761	22087-22094	NN	denotes	pathway
T5762	22094-22095	.	denotes	.
T5763	22095-22329	sentence	denotes	Alternatively, the loss of Sam68 could indirectly regulate bone mass as a general disturbance of neuroendocrine control as was shown when leptin and the sympathetic nervous system axis were shown to negatively regulate bone mass [8].
T5764	22096-22109	RB	denotes	Alternatively
T5765	22146-22154	VB	denotes	regulate
T5766	22109-22111	,	denotes	,
T5767	22111-22114	DT	denotes	the
T5768	22115-22119	NN	denotes	loss
T5769	22120-22122	IN	denotes	of
T5770	22123-22128	NN	denotes	Sam68
T5771	22129-22134	MD	denotes	could
T5772	22135-22145	RB	denotes	indirectly
T5773	22155-22159	NN	denotes	bone
T5774	22160-22164	NN	denotes	mass
T5775	22165-22167	IN	denotes	as
T5776	22168-22169	DT	denotes	a
T5777	22178-22189	NN	denotes	disturbance
T5778	22170-22177	JJ	denotes	general
T5779	22190-22192	IN	denotes	of
T5780	22193-22207	JJ	denotes	neuroendocrine
T5781	22208-22215	NN	denotes	control
T5782	22216-22218	IN	denotes	as
T5783	22223-22228	VBN	denotes	shown
T5784	22219-22222	VBD	denotes	was
T5785	22229-22233	WRB	denotes	when
T5786	22286-22291	VBN	denotes	shown
T5787	22234-22240	NN	denotes	leptin
T5788	22241-22244	CC	denotes	and
T5789	22245-22248	DT	denotes	the
T5790	22276-22280	NN	denotes	axis
T5791	22249-22260	JJ	denotes	sympathetic
T5792	22261-22268	JJ	denotes	nervous
T5793	22269-22275	NN	denotes	system
T5794	22281-22285	VBD	denotes	were
T5795	22292-22294	TO	denotes	to
T5796	22306-22314	VB	denotes	regulate
T5797	22295-22305	RB	denotes	negatively
T5798	22315-22319	NN	denotes	bone
T5799	22320-22324	NN	denotes	mass
T5800	22325-22326	-LRB-	denotes	[
T5801	22326-22327	CD	denotes	8
T5802	22327-22328	-RRB-	denotes	]
T5803	22328-22329	.	denotes	.
T5804	22329-22479	sentence	denotes	To confirm a role for Sam68 in the regulation of adipocyte differentiation, we isolated primary MEFs from 14.5-day-old Sam68+/+ and Sam68−/− embryos.
T5805	22330-22332	TO	denotes	To
T5806	22333-22340	VB	denotes	confirm
T5807	22409-22417	VBD	denotes	isolated
T5808	22341-22342	DT	denotes	a
T5809	22343-22347	NN	denotes	role
T5810	22348-22351	IN	denotes	for
T5811	22352-22357	NN	denotes	Sam68
T5812	22358-22360	IN	denotes	in
T5813	22361-22364	DT	denotes	the
T5814	22365-22375	NN	denotes	regulation
T5815	22376-22378	IN	denotes	of
T5816	22379-22388	NN	denotes	adipocyte
T5817	22389-22404	NN	denotes	differentiation
T5818	22404-22406	,	denotes	,
T5819	22406-22408	PRP	denotes	we
T5820	22418-22425	JJ	denotes	primary
T5821	22426-22430	NNS	denotes	MEFs
T5822	22431-22435	IN	denotes	from
T5823	22436-22440	CD	denotes	14.5
T5824	22441-22444	NN	denotes	day
T5825	22440-22441	HYPH	denotes	-
T5826	22445-22448	JJ	denotes	old
T5827	22444-22445	HYPH	denotes	-
T5828	22471-22478	NNS	denotes	embryos
T5829	22449-22454	NN	denotes	Sam68
T5830	22454-22455	SYM	denotes	+
T5831	22455-22456	HYPH	denotes	/
T5832	22456-22457	SYM	denotes	+
T5833	22458-22461	CC	denotes	and
T5834	22462-22467	NN	denotes	Sam68
T5835	22467-22468	SYM	denotes	−
T5836	22468-22469	HYPH	denotes	/
T5837	22469-22470	SYM	denotes	−
T5838	22478-22479	.	denotes	.
T5839	22479-22621	sentence	denotes	The primary Sam68−/− MEFs were differentiated into adipocytes in vitro in culture medium containing 5 μM pioglitazone to induce adipogenesis.
T5840	22480-22483	DT	denotes	The
T5841	22501-22505	NNS	denotes	MEFs
T5842	22484-22491	JJ	denotes	primary
T5843	22492-22497	NN	denotes	Sam68
T5844	22497-22498	SYM	denotes	−
T5845	22498-22499	HYPH	denotes	/
T5846	22499-22500	SYM	denotes	−
T5847	22511-22525	VBN	denotes	differentiated
T5848	22506-22510	VBD	denotes	were
T5849	22526-22530	IN	denotes	into
T5850	22531-22541	NNS	denotes	adipocytes
T5851	22542-22544	FW	denotes	in
T5852	22545-22550	FW	denotes	vitro
T5853	22551-22553	IN	denotes	in
T5854	22554-22561	NN	denotes	culture
T5855	22562-22568	NN	denotes	medium
T5856	22569-22579	VBG	denotes	containing
T5857	22580-22581	CD	denotes	5
T5858	22582-22584	NN	denotes	μM
T5859	22585-22597	NN	denotes	pioglitazone
T5860	22598-22600	TO	denotes	to
T5861	22601-22607	VB	denotes	induce
T5862	22608-22620	NN	denotes	adipogenesis
T5863	22620-22621	.	denotes	.
T5864	22621-22704	sentence	denotes	Cells at days 0, 4, 6, and 12 were stained with Oil red O to monitor adipogenesis.
T5865	22622-22627	NNS	denotes	Cells
T5866	22657-22664	VBN	denotes	stained
T5867	22628-22630	IN	denotes	at
T5868	22631-22635	NNS	denotes	days
T5869	22636-22637	CD	denotes	0
T5870	22637-22639	,	denotes	,
T5871	22639-22640	CD	denotes	4
T5872	22640-22642	,	denotes	,
T5873	22642-22643	CD	denotes	6
T5874	22643-22645	,	denotes	,
T5875	22645-22648	CC	denotes	and
T5876	22649-22651	CD	denotes	12
T5877	22652-22656	VBD	denotes	were
T5878	22665-22669	IN	denotes	with
T5879	22670-22673	NN	denotes	Oil
T5880	22678-22679	NN	denotes	O
T5881	22674-22677	NN	denotes	red
T5882	22680-22682	TO	denotes	to
T5883	22683-22690	VB	denotes	monitor
T5884	22691-22703	NN	denotes	adipogenesis
T5885	22703-22704	.	denotes	.
T5886	22704-22890	sentence	denotes	Adipogenesis was more pronounced in the wild-type MEFs cultures than in the Sam68−/− MEFs, consistent with the positive role of endogenous Sam68 in adipocyte differentiation (Figure 7).
T5887	22705-22717	NN	denotes	Adipogenesis
T5888	22718-22721	VBD	denotes	was
T5889	22722-22726	RBR	denotes	more
T5890	22727-22737	JJ	denotes	pronounced
T5891	22738-22740	IN	denotes	in
T5892	22741-22744	DT	denotes	the
T5893	22760-22768	NNS	denotes	cultures
T5894	22745-22749	JJ	denotes	wild
T5895	22750-22754	NN	denotes	type
T5896	22749-22750	HYPH	denotes	-
T5897	22755-22759	NNS	denotes	MEFs
T5898	22769-22773	IN	denotes	than
T5899	22774-22776	IN	denotes	in
T5900	22777-22780	DT	denotes	the
T5901	22790-22794	NNS	denotes	MEFs
T5902	22781-22786	NN	denotes	Sam68
T5903	22786-22787	SYM	denotes	−
T5904	22787-22788	HYPH	denotes	/
T5905	22788-22789	SYM	denotes	−
T5906	22794-22796	,	denotes	,
T5907	22796-22806	JJ	denotes	consistent
T5908	22807-22811	IN	denotes	with
T5909	22812-22815	DT	denotes	the
T5910	22825-22829	NN	denotes	role
T5911	22816-22824	JJ	denotes	positive
T5912	22830-22832	IN	denotes	of
T5913	22833-22843	JJ	denotes	endogenous
T5914	22844-22849	NN	denotes	Sam68
T5915	22850-22852	IN	denotes	in
T5916	22853-22862	NN	denotes	adipocyte
T5917	22863-22878	NN	denotes	differentiation
T5918	22879-22880	-LRB-	denotes	(
T5919	22880-22886	NN	denotes	Figure
T5920	22887-22888	CD	denotes	7
T5921	22888-22889	-RRB-	denotes	)
T5922	22889-22890	.	denotes	.
T5923	22890-23111	sentence	denotes	The expression of key transcription factors including the PPARγ and KLF5 was impaired in Sam68−/− differentiated MEFs compared with Sam68+/+ MEFs, consistent with impaired adipogenesis in the absence of Sam68 (Figure 7).
T5924	22891-22894	DT	denotes	The
T5925	22895-22905	NN	denotes	expression
T5926	22968-22976	VBN	denotes	impaired
T5927	22906-22908	IN	denotes	of
T5928	22909-22912	JJ	denotes	key
T5929	22927-22934	NNS	denotes	factors
T5930	22913-22926	NN	denotes	transcription
T5931	22935-22944	VBG	denotes	including
T5932	22945-22948	DT	denotes	the
T5933	22949-22954	NN	denotes	PPARγ
T5934	22955-22958	CC	denotes	and
T5935	22959-22963	NN	denotes	KLF5
T5936	22964-22967	VBD	denotes	was
T5937	22977-22979	IN	denotes	in
T5938	22980-22985	NN	denotes	Sam68
T5939	23004-23008	NNS	denotes	MEFs
T5940	22985-22986	SYM	denotes	−
T5941	22986-22987	HYPH	denotes	/
T5942	22987-22988	SYM	denotes	−
T5943	22989-23003	VBN	denotes	differentiated
T5944	23009-23017	VBN	denotes	compared
T5945	23018-23022	IN	denotes	with
T5946	23023-23028	NN	denotes	Sam68
T5947	23032-23036	NNS	denotes	MEFs
T5948	23028-23029	SYM	denotes	+
T5949	23029-23030	HYPH	denotes	/
T5950	23030-23031	SYM	denotes	+
T5951	23036-23038	,	denotes	,
T5952	23038-23048	JJ	denotes	consistent
T5953	23049-23053	IN	denotes	with
T5954	23054-23062	VBN	denotes	impaired
T5955	23063-23075	NN	denotes	adipogenesis
T5956	23076-23078	IN	denotes	in
T5957	23079-23082	DT	denotes	the
T5958	23083-23090	NN	denotes	absence
T5959	23091-23093	IN	denotes	of
T5960	23094-23099	NN	denotes	Sam68
T5961	23100-23101	-LRB-	denotes	(
T5962	23101-23107	NN	denotes	Figure
T5963	23108-23109	CD	denotes	7
T5964	23109-23110	-RRB-	denotes	)
T5965	23110-23111	.	denotes	.
T5966	23111-23319	sentence	denotes	These data, together with data confirming a lean phenotype in Sam68−/− mice (N. Torabi and S. Richard, unpublished data), support the hypothesis that Sam68 modulates the differentiation of mesenchymal cells.
T5967	23112-23117	DT	denotes	These
T5968	23118-23122	NNS	denotes	data
T5969	23234-23241	VBP	denotes	support
T5970	23122-23124	,	denotes	,
T5971	23124-23132	RB	denotes	together
T5972	23133-23137	IN	denotes	with
T5973	23138-23142	NNS	denotes	data
T5974	23143-23153	VBG	denotes	confirming
T5975	23154-23155	DT	denotes	a
T5976	23161-23170	NN	denotes	phenotype
T5977	23156-23160	JJ	denotes	lean
T5978	23171-23173	IN	denotes	in
T5979	23174-23179	NN	denotes	Sam68
T5980	23183-23187	NNS	denotes	mice
T5981	23179-23180	SYM	denotes	−
T5982	23180-23181	HYPH	denotes	/
T5983	23181-23182	SYM	denotes	−
T5984	23188-23189	-LRB-	denotes	(
T5985	23189-23191	NNP	denotes	N.
T5986	23192-23198	NNP	denotes	Torabi
T5987	23199-23202	CC	denotes	and
T5988	23203-23205	NNP	denotes	S.
T5989	23206-23213	NNP	denotes	Richard
T5990	23213-23215	,	denotes	,
T5991	23215-23226	JJ	denotes	unpublished
T5992	23227-23231	NNS	denotes	data
T5993	23231-23232	-RRB-	denotes	)
T5994	23232-23234	,	denotes	,
T5995	23242-23245	DT	denotes	the
T5996	23246-23256	NN	denotes	hypothesis
T5997	23257-23261	IN	denotes	that
T5998	23268-23277	VBZ	denotes	modulates
T5999	23262-23267	NN	denotes	Sam68
T6000	23278-23281	DT	denotes	the
T6001	23282-23297	NN	denotes	differentiation
T6002	23298-23300	IN	denotes	of
T6003	23301-23312	JJ	denotes	mesenchymal
T6004	23313-23318	NNS	denotes	cells
T6005	23318-23319	.	denotes	.
T6006	23319-24385	sentence	denotes	Figure 7 Ex Vivo Adipogenesis Analysis of Sam68−/− Mouse Embryonic Fibroblasts MEFs were isolated from mouse embryos at embryonic day 14.5. Equal number of MEFs from Sam68+/+ and Sam68−/− was plated on glass cover slips in 24 well-plates. Adipocyte differentiation was carried out at indicated times by the addition of complete media containing the pioglitazone. (A) Cultures were fixed in 4% paraformaldehyde and stained with Oil Red O to detect the fat droplets stored in adipocytes and photographed (top). The cell images were magnified ×10 and ×20 as indicated. (B) RT-PCR was carried out on total cellular RNA isolated after differentiation of the MEFs for day 0, 2, 4, 6, and 12. The DNA fragments were visualized on agarose gels stained with ethidium bromide. The expression of adipogenic markers C/EBPβ, C/EBPδ, PPARα, and KLF5 was examined as well as the expression of controls including Sam68, β-actin, and GAPDH. To further examine this phenotype in a cell autonomous system, we chose the embryonic mesenchymal multipotential progenitor cells C3H10T1/2.
T6007	24245-24247	TO	denotes	To
T6008	24256-24263	VB	denotes	examine
T6009	24248-24255	RB	denotes	further
T6010	24311-24316	VBD	denotes	chose
T6011	24264-24268	DT	denotes	this
T6012	24269-24278	NN	denotes	phenotype
T6013	24279-24281	IN	denotes	in
T6014	24282-24283	DT	denotes	a
T6015	24300-24306	NN	denotes	system
T6016	24284-24288	NN	denotes	cell
T6017	24289-24299	JJ	denotes	autonomous
T6018	24306-24308	,	denotes	,
T6019	24308-24310	PRP	denotes	we
T6020	24317-24320	DT	denotes	the
T6021	24369-24374	NNS	denotes	cells
T6022	24321-24330	JJ	denotes	embryonic
T6023	24331-24342	JJ	denotes	mesenchymal
T6024	24343-24357	JJ	denotes	multipotential
T6025	24358-24368	NN	denotes	progenitor
T6026	24375-24382	NN	denotes	C3H10T1
T6027	24382-24383	HYPH	denotes	/
T6028	24383-24384	CD	denotes	2
T6029	24384-24385	.	denotes	.
T6030	24385-24544	sentence	denotes	The addition of BMP-2 induced osteoblast differentiation, as evidenced by an approximately 400-fold increase in expression of the osteocalcin (OCN) gene [51].
T6031	24386-24389	DT	denotes	The
T6032	24390-24398	NN	denotes	addition
T6033	24408-24415	VBD	denotes	induced
T6034	24399-24401	IN	denotes	of
T6035	24402-24405	NN	denotes	BMP
T6036	24405-24406	HYPH	denotes	-
T6037	24406-24407	CD	denotes	2
T6038	24416-24426	NN	denotes	osteoblast
T6039	24427-24442	NN	denotes	differentiation
T6040	24442-24444	,	denotes	,
T6041	24444-24446	IN	denotes	as
T6042	24447-24456	VBN	denotes	evidenced
T6043	24457-24459	IN	denotes	by
T6044	24460-24462	DT	denotes	an
T6045	24486-24494	NN	denotes	increase
T6046	24463-24476	RB	denotes	approximately
T6047	24477-24485	JJ	denotes	400-fold
T6048	24495-24497	IN	denotes	in
T6049	24498-24508	NN	denotes	expression
T6050	24509-24511	IN	denotes	of
T6051	24512-24515	DT	denotes	the
T6052	24534-24538	NN	denotes	gene
T6053	24516-24527	NN	denotes	osteocalcin
T6054	24528-24529	-LRB-	denotes	(
T6055	24529-24532	NN	denotes	OCN
T6056	24532-24533	-RRB-	denotes	)
T6057	24539-24540	-LRB-	denotes	[
T6058	24540-24542	CD	denotes	51
T6059	24542-24543	-RRB-	denotes	]
T6060	24543-24544	.	denotes	.
T6061	24544-24726	sentence	denotes	Populations of C3H10T1/2 cells stably transfected with either pSuper-retro (control) and pSuper-retro harboring a short hairpin against Sam68 (Sam68sh) were selected with puromycin.
T6062	24545-24556	NNS	denotes	Populations
T6063	24702-24710	VBN	denotes	selected
T6064	24557-24559	IN	denotes	of
T6065	24560-24567	NN	denotes	C3H10T1
T6066	24570-24575	NNS	denotes	cells
T6067	24567-24568	HYPH	denotes	/
T6068	24568-24569	CD	denotes	2
T6069	24576-24582	RB	denotes	stably
T6070	24583-24594	VBN	denotes	transfected
T6071	24595-24599	IN	denotes	with
T6072	24600-24606	CC	denotes	either
T6073	24614-24619	NN	denotes	retro
T6074	24607-24613	NN	denotes	pSuper
T6075	24613-24614	HYPH	denotes	-
T6076	24620-24621	-LRB-	denotes	(
T6077	24621-24628	NN	denotes	control
T6078	24628-24629	-RRB-	denotes	)
T6079	24630-24633	CC	denotes	and
T6080	24634-24640	NN	denotes	pSuper
T6081	24641-24646	NN	denotes	retro
T6082	24640-24641	HYPH	denotes	-
T6083	24647-24656	VBG	denotes	harboring
T6084	24657-24658	DT	denotes	a
T6085	24665-24672	NN	denotes	hairpin
T6086	24659-24664	JJ	denotes	short
T6087	24673-24680	IN	denotes	against
T6088	24681-24686	NN	denotes	Sam68
T6089	24687-24688	-LRB-	denotes	(
T6090	24688-24695	NN	denotes	Sam68sh
T6091	24695-24696	-RRB-	denotes	)
T6092	24697-24701	VBD	denotes	were
T6093	24711-24715	IN	denotes	with
T6094	24716-24725	NN	denotes	puromycin
T6095	24725-24726	.	denotes	.
T6096	24726-24867	sentence	denotes	The expression of Sam68 was reduced by approximately 80% as evidenced by immunoblot analyses using β-actin as a loading control (Figure 8A).
T6097	24727-24730	DT	denotes	The
T6098	24731-24741	NN	denotes	expression
T6099	24755-24762	VBN	denotes	reduced
T6100	24742-24744	IN	denotes	of
T6101	24745-24750	NN	denotes	Sam68
T6102	24751-24754	VBD	denotes	was
T6103	24763-24765	IN	denotes	by
T6104	24766-24779	RB	denotes	approximately
T6105	24780-24782	CD	denotes	80
T6106	24782-24783	NN	denotes	%
T6107	24784-24786	IN	denotes	as
T6108	24787-24796	VBN	denotes	evidenced
T6109	24797-24799	IN	denotes	by
T6110	24800-24810	NN	denotes	immunoblot
T6111	24811-24819	NNS	denotes	analyses
T6112	24820-24825	VBG	denotes	using
T6113	24826-24827	NN	denotes	β
T6114	24828-24833	NN	denotes	actin
T6115	24827-24828	HYPH	denotes	-
T6116	24834-24836	IN	denotes	as
T6117	24837-24838	DT	denotes	a
T6118	24847-24854	NN	denotes	control
T6119	24839-24846	NN	denotes	loading
T6120	24855-24856	-LRB-	denotes	(
T6121	24863-24865	NN	denotes	8A
T6122	24856-24862	NN	denotes	Figure
T6123	24865-24866	-RRB-	denotes	)
T6124	24866-24867	.	denotes	.
T6125	24867-25012	sentence	denotes	Osteoblast differentiation was induced in cultures expressing pSuper-retro or pSuper-retro Sam68sh by addition of BMP-2 to the culture medium. .
T6126	24868-24878	NN	denotes	Osteoblast
T6127	24879-24894	NN	denotes	differentiation
T6128	24899-24906	VBN	denotes	induced
T6129	24895-24898	VBD	denotes	was
T6130	24907-24909	IN	denotes	in
T6131	24910-24918	NNS	denotes	cultures
T6132	24919-24929	VBG	denotes	expressing
T6133	24930-24936	NN	denotes	pSuper
T6134	24937-24942	NN	denotes	retro
T6135	24936-24937	HYPH	denotes	-
T6136	24943-24945	CC	denotes	or
T6137	24946-24952	NN	denotes	pSuper
T6138	24953-24958	NN	denotes	retro
T6139	24952-24953	HYPH	denotes	-
T6140	24959-24966	NN	denotes	Sam68sh
T6141	24967-24969	IN	denotes	by
T6142	24970-24978	NN	denotes	addition
T6143	24979-24981	IN	denotes	of
T6144	24982-24985	NN	denotes	BMP
T6145	24985-24986	HYPH	denotes	-
T6146	24986-24987	CD	denotes	2
T6147	24988-24990	IN	denotes	to
T6148	24991-24994	DT	denotes	the
T6149	25003-25009	NN	denotes	medium
T6150	24995-25002	NN	denotes	culture
T6151	25009-25010	.	denotes	.
T6152	25011-25012	.	denotes	.
T6153	25012-25253	sentence	denotes	The expression of OCN and β-actin mRNAs was examined by semiquantitative RT-PCR and the Sam68sh-expressing cells displayed a more pronounced osteoblast phenotype compared with control cells, as assessed by the expression of OCN (Figure 8B).
T6154	25013-25016	DT	denotes	The
T6155	25017-25027	NN	denotes	expression
T6156	25057-25065	VBN	denotes	examined
T6157	25028-25030	IN	denotes	of
T6158	25031-25034	NN	denotes	OCN
T6159	25035-25038	CC	denotes	and
T6160	25039-25040	NN	denotes	β
T6161	25041-25046	NN	denotes	actin
T6162	25040-25041	HYPH	denotes	-
T6163	25047-25052	NNS	denotes	mRNAs
T6164	25053-25056	VBD	denotes	was
T6165	25066-25068	IN	denotes	by
T6166	25069-25085	JJ	denotes	semiquantitative
T6167	25089-25092	NN	denotes	PCR
T6168	25086-25088	NN	denotes	RT
T6169	25088-25089	HYPH	denotes	-
T6170	25093-25096	CC	denotes	and
T6171	25097-25100	DT	denotes	the
T6172	25120-25125	NNS	denotes	cells
T6173	25101-25108	NN	denotes	Sam68sh
T6174	25109-25119	VBG	denotes	expressing
T6175	25108-25109	HYPH	denotes	-
T6176	25126-25135	VBD	denotes	displayed
T6177	25136-25137	DT	denotes	a
T6178	25165-25174	NN	denotes	phenotype
T6179	25138-25142	RBR	denotes	more
T6180	25143-25153	JJ	denotes	pronounced
T6181	25154-25164	NN	denotes	osteoblast
T6182	25175-25183	VBN	denotes	compared
T6183	25184-25188	IN	denotes	with
T6184	25189-25196	NN	denotes	control
T6185	25197-25202	NNS	denotes	cells
T6186	25202-25204	,	denotes	,
T6187	25204-25206	IN	denotes	as
T6188	25207-25215	VBN	denotes	assessed
T6189	25216-25218	IN	denotes	by
T6190	25219-25222	DT	denotes	the
T6191	25223-25233	NN	denotes	expression
T6192	25234-25236	IN	denotes	of
T6193	25237-25240	NN	denotes	OCN
T6194	25241-25242	-LRB-	denotes	(
T6195	25249-25251	NN	denotes	8B
T6196	25242-25248	NN	denotes	Figure
T6197	25251-25252	-RRB-	denotes	)
T6198	25252-25253	.	denotes	.
T6199	25253-26386	sentence	denotes	Figure 8 Enhanced Osteogenic Differentiation of the C3HT101/2 Embryonic Cell Line Depleted of Endogenous Sam68 (A) C3HT101/2 cells transfected with an empty vector (pSuper-retro) or a vector containing an shRNA (Sam68 shRNA) were selected with puromycin, and knockdown populations depleted of Sam68 were identified. The reduction in Sam68 protein was analyzed by immunoblotting with anti-Sam68 (AD1) antibody and anti–β-actin antibodies as loading controls. (B) Osteogenic differentiation was carried out with conditioned medium containing BMP-2 for the indicated times. To assess the level of osteogenic differentiation in these cells, expression of late osteoblast marker, osteocalcin (OCN), was analyzed by RT-PCR and compared with β-actin and GAPDH controls. The DNA fragments were visualized by agarose gel stained with ethidium bromide. Given the apparent enhancement of mineralized nodule formation by Sam68−/− bone marrow stromal cells ex vivo and the phenotype observed with short hairpin RNA (shRNA)-treated C3H10T1/2, we stained sections of bone from 4- and 12-month-old mice for evidence of changes in marrow adiposity.
T6200	26098-26103	VBN	denotes	Given
T6201	26287-26294	VBD	denotes	stained
T6202	26104-26107	DT	denotes	the
T6203	26117-26128	NN	denotes	enhancement
T6204	26108-26116	JJ	denotes	apparent
T6205	26129-26131	IN	denotes	of
T6206	26132-26143	VBN	denotes	mineralized
T6207	26144-26150	NN	denotes	nodule
T6208	26151-26160	NN	denotes	formation
T6209	26161-26163	IN	denotes	by
T6210	26164-26169	NN	denotes	Sam68
T6211	26193-26198	NNS	denotes	cells
T6212	26169-26170	SYM	denotes	−
T6213	26170-26171	HYPH	denotes	/
T6214	26171-26172	SYM	denotes	−
T6215	26173-26177	NN	denotes	bone
T6216	26178-26184	NN	denotes	marrow
T6217	26185-26192	JJ	denotes	stromal
T6218	26199-26201	FW	denotes	ex
T6219	26202-26206	FW	denotes	vivo
T6220	26207-26210	CC	denotes	and
T6221	26211-26214	DT	denotes	the
T6222	26215-26224	NN	denotes	phenotype
T6223	26225-26233	VBN	denotes	observed
T6224	26234-26238	IN	denotes	with
T6225	26239-26244	JJ	denotes	short
T6226	26253-26256	NN	denotes	RNA
T6227	26245-26252	NN	denotes	hairpin
T6228	26265-26272	VBN	denotes	treated
T6229	26257-26258	-LRB-	denotes	(
T6230	26258-26263	NN	denotes	shRNA
T6231	26263-26264	-RRB-	denotes	)
T6232	26264-26265	HYPH	denotes	-
T6233	26273-26280	NN	denotes	C3H10T1
T6234	26280-26281	HYPH	denotes	/
T6235	26281-26282	CD	denotes	2
T6236	26282-26284	,	denotes	,
T6237	26284-26286	PRP	denotes	we
T6238	26295-26303	NNS	denotes	sections
T6239	26304-26306	IN	denotes	of
T6240	26307-26311	NN	denotes	bone
T6241	26312-26316	IN	denotes	from
T6242	26317-26318	CD	denotes	4
T6243	26327-26332	NN	denotes	month
T6244	26318-26319	HYPH	denotes	-
T6245	26320-26323	CC	denotes	and
T6246	26324-26326	CD	denotes	12
T6247	26326-26327	HYPH	denotes	-
T6248	26333-26336	JJ	denotes	old
T6249	26332-26333	HYPH	denotes	-
T6250	26337-26341	NNS	denotes	mice
T6251	26342-26345	IN	denotes	for
T6252	26346-26354	NN	denotes	evidence
T6253	26355-26357	IN	denotes	of
T6254	26358-26365	NNS	denotes	changes
T6255	26366-26368	IN	denotes	in
T6256	26369-26375	NN	denotes	marrow
T6257	26376-26385	NN	denotes	adiposity
T6258	26385-26386	.	denotes	.
T6259	26386-26704	sentence	denotes	Figure 9 shows sections of undecalcified bone from 4- and 12-month-old Sam68+/+ and Sam68−/− mice stained with von Kossa and toluidine blue to show mineralized tissue (Figure 9A, black) and marrow adipocytes (Figure 9B, white) and left unstained to show fluorochrome labeling of the mineralization fronts (Figure 9C).
T6260	26387-26393	NN	denotes	Figure
T6261	26396-26401	VBZ	denotes	shows
T6262	26394-26395	CD	denotes	9
T6263	26402-26410	NNS	denotes	sections
T6264	26411-26413	IN	denotes	of
T6265	26414-26427	JJ	denotes	undecalcified
T6266	26428-26432	NN	denotes	bone
T6267	26433-26437	IN	denotes	from
T6268	26438-26439	CD	denotes	4
T6269	26448-26453	NN	denotes	month
T6270	26439-26440	HYPH	denotes	-
T6271	26441-26444	CC	denotes	and
T6272	26445-26447	CD	denotes	12
T6273	26447-26448	HYPH	denotes	-
T6274	26454-26457	JJ	denotes	old
T6275	26453-26454	HYPH	denotes	-
T6276	26480-26484	NNS	denotes	mice
T6277	26458-26463	NN	denotes	Sam68
T6278	26463-26464	SYM	denotes	+
T6279	26464-26465	HYPH	denotes	/
T6280	26465-26466	SYM	denotes	+
T6281	26467-26470	CC	denotes	and
T6282	26471-26476	NN	denotes	Sam68
T6283	26476-26477	SYM	denotes	−
T6284	26477-26478	HYPH	denotes	/
T6285	26478-26479	SYM	denotes	−
T6286	26485-26492	VBN	denotes	stained
T6287	26493-26497	IN	denotes	with
T6288	26498-26501	NNP	denotes	von
T6289	26502-26507	NNP	denotes	Kossa
T6290	26508-26511	CC	denotes	and
T6291	26512-26521	NN	denotes	toluidine
T6292	26522-26526	JJ	denotes	blue
T6293	26527-26529	TO	denotes	to
T6294	26530-26534	VB	denotes	show
T6295	26535-26546	VBN	denotes	mineralized
T6296	26547-26553	NN	denotes	tissue
T6297	26554-26555	-LRB-	denotes	(
T6298	26562-26564	NN	denotes	9A
T6299	26555-26561	NN	denotes	Figure
T6300	26564-26566	,	denotes	,
T6301	26566-26571	JJ	denotes	black
T6302	26571-26572	-RRB-	denotes	)
T6303	26573-26576	CC	denotes	and
T6304	26577-26583	NN	denotes	marrow
T6305	26584-26594	NNS	denotes	adipocytes
T6306	26595-26596	-LRB-	denotes	(
T6307	26603-26605	NN	denotes	9B
T6308	26596-26602	NN	denotes	Figure
T6309	26605-26607	,	denotes	,
T6310	26607-26612	JJ	denotes	white
T6311	26612-26613	-RRB-	denotes	)
T6312	26614-26617	CC	denotes	and
T6313	26618-26622	VBD	denotes	left
T6314	26623-26632	JJ	denotes	unstained
T6315	26633-26635	TO	denotes	to
T6316	26636-26640	VB	denotes	show
T6317	26641-26653	NN	denotes	fluorochrome
T6318	26654-26662	NN	denotes	labeling
T6319	26663-26665	IN	denotes	of
T6320	26666-26669	DT	denotes	the
T6321	26685-26691	NNS	denotes	fronts
T6322	26670-26684	NN	denotes	mineralization
T6323	26692-26693	-LRB-	denotes	(
T6324	26700-26702	NN	denotes	9C
T6325	26693-26699	NN	denotes	Figure
T6326	26702-26703	-RRB-	denotes	)
T6327	26703-26704	.	denotes	.
T6328	26704-26957	sentence	denotes	Twelve-month-old Sam68+/+ mice showed a noticeable decrease in trabecular bone (Figure 9A), which was associated with a significant increase in marrow adiposity (Figure 9B) and with the two fluorochrome labels superimposed upon one another (Figure 9C).
T6329	26705-26711	CD	denotes	Twelve
T6330	26712-26717	NN	denotes	month
T6331	26711-26712	HYPH	denotes	-
T6332	26718-26721	JJ	denotes	old
T6333	26717-26718	HYPH	denotes	-
T6334	26731-26735	NNS	denotes	mice
T6335	26722-26727	NN	denotes	Sam68
T6336	26727-26728	SYM	denotes	+
T6337	26728-26729	HYPH	denotes	/
T6338	26729-26730	SYM	denotes	+
T6339	26736-26742	VBD	denotes	showed
T6340	26743-26744	DT	denotes	a
T6341	26756-26764	NN	denotes	decrease
T6342	26745-26755	JJ	denotes	noticeable
T6343	26765-26767	IN	denotes	in
T6344	26768-26778	JJ	denotes	trabecular
T6345	26779-26783	NN	denotes	bone
T6346	26784-26785	-LRB-	denotes	(
T6347	26792-26794	NN	denotes	9A
T6348	26785-26791	NN	denotes	Figure
T6349	26794-26795	-RRB-	denotes	)
T6350	26795-26797	,	denotes	,
T6351	26797-26802	WDT	denotes	which
T6352	26807-26817	VBN	denotes	associated
T6353	26803-26806	VBD	denotes	was
T6354	26818-26822	IN	denotes	with
T6355	26823-26824	DT	denotes	a
T6356	26837-26845	NN	denotes	increase
T6357	26825-26836	JJ	denotes	significant
T6358	26846-26848	IN	denotes	in
T6359	26849-26855	NN	denotes	marrow
T6360	26856-26865	NN	denotes	adiposity
T6361	26866-26867	-LRB-	denotes	(
T6362	26874-26876	NN	denotes	9B
T6363	26867-26873	NN	denotes	Figure
T6364	26876-26877	-RRB-	denotes	)
T6365	26878-26881	CC	denotes	and
T6366	26882-26886	IN	denotes	with
T6367	26887-26890	DT	denotes	the
T6368	26908-26914	NNS	denotes	labels
T6369	26891-26894	CD	denotes	two
T6370	26895-26907	NN	denotes	fluorochrome
T6371	26915-26927	VBN	denotes	superimposed
T6372	26928-26932	IN	denotes	upon
T6373	26933-26936	CD	denotes	one
T6374	26937-26944	DT	denotes	another
T6375	26945-26946	-LRB-	denotes	(
T6376	26953-26955	NN	denotes	9C
T6377	26946-26952	NN	denotes	Figure
T6378	26955-26956	-RRB-	denotes	)
T6379	26956-26957	.	denotes	.
T6380	26957-27080	sentence	denotes	In contrast, the bones of 12-month-old Sam68−/− mice appeared similar to those of the 4-month-old mice of either genotype.
T6381	26958-26960	IN	denotes	In
T6382	27011-27019	VBD	denotes	appeared
T6383	26961-26969	NN	denotes	contrast
T6384	26969-26971	,	denotes	,
T6385	26971-26974	DT	denotes	the
T6386	26975-26980	NNS	denotes	bones
T6387	26981-26983	IN	denotes	of
T6388	26984-26986	CD	denotes	12
T6389	26987-26992	NN	denotes	month
T6390	26986-26987	HYPH	denotes	-
T6391	26993-26996	JJ	denotes	old
T6392	26992-26993	HYPH	denotes	-
T6393	27006-27010	NNS	denotes	mice
T6394	26997-27002	NN	denotes	Sam68
T6395	27002-27003	SYM	denotes	−
T6396	27003-27004	HYPH	denotes	/
T6397	27004-27005	SYM	denotes	−
T6398	27020-27027	JJ	denotes	similar
T6399	27028-27030	IN	denotes	to
T6400	27031-27036	DT	denotes	those
T6401	27037-27039	IN	denotes	of
T6402	27040-27043	DT	denotes	the
T6403	27056-27060	NNS	denotes	mice
T6404	27044-27045	CD	denotes	4
T6405	27046-27051	NN	denotes	month
T6406	27045-27046	HYPH	denotes	-
T6407	27052-27055	JJ	denotes	old
T6408	27051-27052	HYPH	denotes	-
T6409	27061-27063	IN	denotes	of
T6410	27064-27070	DT	denotes	either
T6411	27071-27079	NN	denotes	genotype
T6412	27079-27080	.	denotes	.
T6413	27080-27268	sentence	denotes	These data demonstrate that Sam68 regulates the differentiation of bone marrow mesenchymal cells to promote adipocyte differentiation and inhibit osteoblast differentiation in aging bone.
T6414	27081-27086	DT	denotes	These
T6415	27087-27091	NNS	denotes	data
T6416	27092-27103	VBP	denotes	demonstrate
T6417	27104-27108	IN	denotes	that
T6418	27115-27124	VBZ	denotes	regulates
T6419	27109-27114	NN	denotes	Sam68
T6420	27125-27128	DT	denotes	the
T6421	27129-27144	NN	denotes	differentiation
T6422	27145-27147	IN	denotes	of
T6423	27148-27152	NN	denotes	bone
T6424	27153-27159	NN	denotes	marrow
T6425	27172-27177	NNS	denotes	cells
T6426	27160-27171	JJ	denotes	mesenchymal
T6427	27178-27180	TO	denotes	to
T6428	27181-27188	VB	denotes	promote
T6429	27189-27198	NN	denotes	adipocyte
T6430	27199-27214	NN	denotes	differentiation
T6431	27215-27218	CC	denotes	and
T6432	27219-27226	VB	denotes	inhibit
T6433	27227-27237	NN	denotes	osteoblast
T6434	27238-27253	NN	denotes	differentiation
T6435	27254-27256	IN	denotes	in
T6436	27257-27262	VBG	denotes	aging
T6437	27263-27267	NN	denotes	bone
T6438	27267-27268	.	denotes	.
T7333	27953-27956	DT	denotes	The
T7334	27965-27970	NN	denotes	study
T7335	27957-27964	JJ	denotes	present
T7336	27971-27979	VBZ	denotes	provides
T7337	27980-27988	NN	denotes	evidence
T7338	27989-27993	IN	denotes	that
T7339	28022-28024	VBZ	denotes	is
T7340	27994-27995	DT	denotes	a
T7341	28008-28012	NN	denotes	role
T7342	27996-28007	JJ	denotes	physiologic
T7343	28013-28015	IN	denotes	of
T7344	28016-28021	NN	denotes	Sam68
T7345	28025-28027	TO	denotes	to
T7346	28028-28036	VB	denotes	modulate
T7347	28037-28041	NN	denotes	bone
T7348	28042-28048	NN	denotes	marrow
T7349	28066-28071	NNS	denotes	cells
T7350	28049-28060	JJ	denotes	mesenchymal
T7351	28061-28065	NN	denotes	stem
T7352	28071-28072	.	denotes	.
T7353	28072-28180	sentence	denotes	Young Sam68−/− mice developed normally and contained similar bone mass compared with wild-type littermates.
T7354	28073-28078	JJ	denotes	Young
T7355	28088-28092	NNS	denotes	mice
T7356	28079-28084	NN	denotes	Sam68
T7357	28084-28085	SYM	denotes	−
T7358	28085-28086	HYPH	denotes	/
T7359	28086-28087	SYM	denotes	−
T7360	28093-28102	VBD	denotes	developed
T7361	28103-28111	RB	denotes	normally
T7362	28112-28115	CC	denotes	and
T7363	28116-28125	VBD	denotes	contained
T7364	28126-28133	JJ	denotes	similar
T7365	28139-28143	NN	denotes	mass
T7366	28134-28138	NN	denotes	bone
T7367	28144-28152	VBN	denotes	compared
T7368	28153-28157	IN	denotes	with
T7369	28158-28162	JJ	denotes	wild
T7370	28163-28167	NN	denotes	type
T7371	28162-28163	HYPH	denotes	-
T7372	28168-28179	NNS	denotes	littermates
T7373	28179-28180	.	denotes	.
T7374	28180-28284	sentence	denotes	Aged (12 months) Sam68−/− mice displayed a high bone mass phenotype compared with Sam68+/+ littermates.
T7375	28181-28185	VBN	denotes	Aged
T7376	28207-28211	NNS	denotes	mice
T7377	28186-28187	-LRB-	denotes	(
T7378	28190-28196	NNS	denotes	months
T7379	28187-28189	CD	denotes	12
T7380	28196-28197	-RRB-	denotes	)
T7381	28198-28203	NN	denotes	Sam68
T7382	28203-28204	SYM	denotes	−
T7383	28204-28205	HYPH	denotes	/
T7384	28205-28206	SYM	denotes	−
T7385	28212-28221	VBD	denotes	displayed
T7386	28222-28223	DT	denotes	a
T7387	28239-28248	NN	denotes	phenotype
T7388	28224-28228	JJ	denotes	high
T7389	28234-28238	NN	denotes	mass
T7390	28229-28233	NN	denotes	bone
T7391	28249-28257	VBN	denotes	compared
T7392	28258-28262	IN	denotes	with
T7393	28263-28268	NN	denotes	Sam68
T7394	28272-28283	NNS	denotes	littermates
T7395	28268-28269	SYM	denotes	+
T7396	28269-28270	HYPH	denotes	/
T7397	28270-28271	SYM	denotes	+
T7398	28283-28284	.	denotes	.
T7399	28284-28441	sentence	denotes	The wild-type littermates underwent age-related bone loss that occurs naturally in mammals, while the Sam68−/− animals preserved their bone mass with aging.
T7400	28285-28288	DT	denotes	The
T7401	28299-28310	NNS	denotes	littermates
T7402	28289-28293	JJ	denotes	wild
T7403	28294-28298	NN	denotes	type
T7404	28293-28294	HYPH	denotes	-
T7405	28311-28320	VBD	denotes	underwent
T7406	28321-28324	NN	denotes	age
T7407	28325-28332	VBN	denotes	related
T7408	28324-28325	HYPH	denotes	-
T7409	28338-28342	NN	denotes	loss
T7410	28333-28337	NN	denotes	bone
T7411	28343-28347	WDT	denotes	that
T7412	28348-28354	VBZ	denotes	occurs
T7413	28355-28364	RB	denotes	naturally
T7414	28365-28367	IN	denotes	in
T7415	28368-28375	NNS	denotes	mammals
T7416	28375-28377	,	denotes	,
T7417	28377-28382	IN	denotes	while
T7418	28404-28413	VBD	denotes	preserved
T7419	28383-28386	DT	denotes	the
T7420	28396-28403	NNS	denotes	animals
T7421	28387-28392	NN	denotes	Sam68
T7422	28392-28393	SYM	denotes	−
T7423	28393-28394	HYPH	denotes	/
T7424	28394-28395	SYM	denotes	−
T7425	28414-28419	PRP$	denotes	their
T7426	28425-28429	NN	denotes	mass
T7427	28420-28424	NN	denotes	bone
T7428	28430-28434	IN	denotes	with
T7429	28435-28440	NN	denotes	aging
T7430	28440-28441	.	denotes	.
T7431	28441-28666	sentence	denotes	The differentiation of bone marrow stem cells isolated from Sam68−/− mice and embryonic mesenchymal multipotential progenitor cells C3H10T1/2 treated with Sam68 shRNA resulted in a more pronounced osteoblast differentiation.
T7432	28442-28445	DT	denotes	The
T7433	28446-28461	NN	denotes	differentiation
T7434	28609-28617	VBD	denotes	resulted
T7435	28462-28464	IN	denotes	of
T7436	28465-28469	NN	denotes	bone
T7437	28470-28476	NN	denotes	marrow
T7438	28482-28487	NNS	denotes	cells
T7439	28477-28481	NN	denotes	stem
T7440	28488-28496	VBN	denotes	isolated
T7441	28497-28501	IN	denotes	from
T7442	28502-28507	NN	denotes	Sam68
T7443	28511-28515	NNS	denotes	mice
T7444	28507-28508	SYM	denotes	−
T7445	28508-28509	HYPH	denotes	/
T7446	28509-28510	SYM	denotes	−
T7447	28516-28519	CC	denotes	and
T7448	28520-28529	JJ	denotes	embryonic
T7449	28568-28573	NNS	denotes	cells
T7450	28530-28541	JJ	denotes	mesenchymal
T7451	28542-28556	JJ	denotes	multipotential
T7452	28557-28567	NN	denotes	progenitor
T7453	28574-28581	NN	denotes	C3H10T1
T7454	28581-28582	HYPH	denotes	/
T7455	28582-28583	CD	denotes	2
T7456	28584-28591	VBN	denotes	treated
T7457	28592-28596	IN	denotes	with
T7458	28597-28602	NN	denotes	Sam68
T7459	28603-28608	NN	denotes	shRNA
T7460	28618-28620	IN	denotes	in
T7461	28621-28622	DT	denotes	a
T7462	28650-28665	NN	denotes	differentiation
T7463	28623-28627	RBR	denotes	more
T7464	28628-28638	JJ	denotes	pronounced
T7465	28639-28649	NN	denotes	osteoblast
T7466	28665-28666	.	denotes	.
T7467	28666-28753	sentence	denotes	These findings demonstrate that the loss of Sam68 enhances osteoblast differentiation.
T7468	28667-28672	DT	denotes	These
T7469	28673-28681	NNS	denotes	findings
T7470	28682-28693	VBP	denotes	demonstrate
T7471	28694-28698	IN	denotes	that
T7472	28717-28725	VBZ	denotes	enhances
T7473	28699-28702	DT	denotes	the
T7474	28703-28707	NN	denotes	loss
T7475	28708-28710	IN	denotes	of
T7476	28711-28716	NN	denotes	Sam68
T7477	28726-28736	NN	denotes	osteoblast
T7478	28737-28752	NN	denotes	differentiation
T7479	28752-28753	.	denotes	.
T7480	28753-28917	sentence	denotes	The converse was also true, as MEFs isolated from Sam68−/− animals were impaired in their ability to undergo adipocyte differentiation compared with Sam68+/+ MEFs.
T7481	28754-28757	DT	denotes	The
T7482	28758-28766	NN	denotes	converse
T7483	28767-28770	VBD	denotes	was
T7484	28771-28775	RB	denotes	also
T7485	28776-28780	JJ	denotes	true
T7486	28780-28782	,	denotes	,
T7487	28782-28784	IN	denotes	as
T7488	28826-28834	VBN	denotes	impaired
T7489	28785-28789	NNS	denotes	MEFs
T7490	28790-28798	VBN	denotes	isolated
T7491	28799-28803	IN	denotes	from
T7492	28804-28809	NN	denotes	Sam68
T7493	28813-28820	NNS	denotes	animals
T7494	28809-28810	SYM	denotes	−
T7495	28810-28811	HYPH	denotes	/
T7496	28811-28812	SYM	denotes	−
T7497	28821-28825	VBD	denotes	were
T7498	28835-28837	IN	denotes	in
T7499	28838-28843	PRP$	denotes	their
T7500	28844-28851	NN	denotes	ability
T7501	28852-28854	TO	denotes	to
T7502	28855-28862	VB	denotes	undergo
T7503	28863-28872	NN	denotes	adipocyte
T7504	28873-28888	NN	denotes	differentiation
T7505	28889-28897	VBN	denotes	compared
T7506	28898-28902	IN	denotes	with
T7507	28903-28908	NN	denotes	Sam68
T7508	28912-28916	NNS	denotes	MEFs
T7509	28908-28909	SYM	denotes	+
T7510	28909-28910	HYPH	denotes	/
T7511	28910-28911	SYM	denotes	+
T7512	28916-28917	.	denotes	.
T7513	28917-29083	sentence	denotes	These findings suggest that a physiologic role for Sam68 is to regulate the balance between adipogenic and osteogenic differentiation of the bone marrow mesenchymal.
T7514	28918-28923	DT	denotes	These
T7515	28924-28932	NNS	denotes	findings
T7516	28933-28940	VBP	denotes	suggest
T7517	28941-28945	IN	denotes	that
T7518	28975-28977	VBZ	denotes	is
T7519	28946-28947	DT	denotes	a
T7520	28960-28964	NN	denotes	role
T7521	28948-28959	JJ	denotes	physiologic
T7522	28965-28968	IN	denotes	for
T7523	28969-28974	NN	denotes	Sam68
T7524	28978-28980	TO	denotes	to
T7525	28981-28989	VB	denotes	regulate
T7526	28990-28993	DT	denotes	the
T7527	28994-29001	NN	denotes	balance
T7528	29002-29009	IN	denotes	between
T7529	29010-29020	JJ	denotes	adipogenic
T7530	29036-29051	NN	denotes	differentiation
T7531	29021-29024	CC	denotes	and
T7532	29025-29035	JJ	denotes	osteogenic
T7533	29052-29054	IN	denotes	of
T7534	29055-29058	DT	denotes	the
T7535	29064-29070	NN	denotes	marrow
T7536	29059-29063	NN	denotes	bone
T7537	29071-29082	JJ	denotes	mesenchymal
T7538	29082-29083	.	denotes	.
T7539	29083-29254	sentence	denotes	Sam68 protein expression was observed throughout the developing mouse embryo, in keeping with previous reports that identified the Sam68 mRNA to be widely expressed [38].
T7540	29084-29089	NN	denotes	Sam68
T7541	29098-29108	NN	denotes	expression
T7542	29090-29097	NN	denotes	protein
T7543	29113-29121	VBN	denotes	observed
T7544	29109-29112	VBD	denotes	was
T7545	29122-29132	IN	denotes	throughout
T7546	29133-29136	DT	denotes	the
T7547	29154-29160	NN	denotes	embryo
T7548	29137-29147	VBG	denotes	developing
T7549	29148-29153	NN	denotes	mouse
T7550	29160-29162	,	denotes	,
T7551	29162-29164	IN	denotes	in
T7552	29165-29172	VBG	denotes	keeping
T7553	29173-29177	IN	denotes	with
T7554	29178-29186	JJ	denotes	previous
T7555	29187-29194	NNS	denotes	reports
T7556	29195-29199	WDT	denotes	that
T7557	29200-29210	VBD	denotes	identified
T7558	29211-29214	DT	denotes	the
T7559	29221-29225	NN	denotes	mRNA
T7560	29215-29220	NN	denotes	Sam68
T7561	29239-29248	VBN	denotes	expressed
T7562	29226-29228	TO	denotes	to
T7563	29229-29231	VB	denotes	be
T7564	29232-29238	RB	denotes	widely
T7565	29249-29250	-LRB-	denotes	[
T7566	29250-29252	CD	denotes	38
T7567	29252-29253	-RRB-	denotes	]
T7568	29253-29254	.	denotes	.
T7569	29254-29407	sentence	denotes	We observe Sam68 staining in the brain, heart, and intestine (see Figure 1) as well as liver, skin, and kidney (unpublished data) of late-stage embryos.
T7570	29255-29257	PRP	denotes	We
T7571	29258-29265	VBP	denotes	observe
T7572	29266-29271	NN	denotes	Sam68
T7573	29272-29280	NN	denotes	staining
T7574	29281-29283	IN	denotes	in
T7575	29284-29287	DT	denotes	the
T7576	29288-29293	NN	denotes	brain
T7577	29293-29295	,	denotes	,
T7578	29295-29300	NN	denotes	heart
T7579	29300-29302	,	denotes	,
T7580	29302-29305	CC	denotes	and
T7581	29306-29315	NN	denotes	intestine
T7582	29316-29317	-LRB-	denotes	(
T7583	29317-29320	VB	denotes	see
T7584	29321-29327	NN	denotes	Figure
T7585	29328-29329	CD	denotes	1
T7586	29329-29330	-RRB-	denotes	)
T7587	29331-29333	RB	denotes	as
T7588	29339-29341	IN	denotes	as
T7589	29334-29338	RB	denotes	well
T7590	29342-29347	NN	denotes	liver
T7591	29347-29349	,	denotes	,
T7592	29349-29353	NN	denotes	skin
T7593	29353-29355	,	denotes	,
T7594	29355-29358	CC	denotes	and
T7595	29359-29365	NN	denotes	kidney
T7596	29366-29367	-LRB-	denotes	(
T7597	29379-29383	NNS	denotes	data
T7598	29367-29378	JJ	denotes	unpublished
T7599	29383-29384	-RRB-	denotes	)
T7600	29385-29387	IN	denotes	of
T7601	29388-29392	JJ	denotes	late
T7602	29393-29398	NN	denotes	stage
T7603	29392-29393	HYPH	denotes	-
T7604	29399-29406	NNS	denotes	embryos
T7605	29406-29407	.	denotes	.
T7606	29407-29571	sentence	denotes	This expression pattern is consistent with previous work that has observed Sam68 in neurons [52] and as a substrate of the intestinal SIK/breast tumor kinase [43].
T7607	29408-29412	DT	denotes	This
T7608	29424-29431	NN	denotes	pattern
T7609	29413-29423	NN	denotes	expression
T7610	29432-29434	VBZ	denotes	is
T7611	29435-29445	JJ	denotes	consistent
T7612	29446-29450	IN	denotes	with
T7613	29451-29459	JJ	denotes	previous
T7614	29460-29464	NN	denotes	work
T7615	29465-29469	WDT	denotes	that
T7616	29474-29482	VBN	denotes	observed
T7617	29470-29473	VBZ	denotes	has
T7618	29483-29488	NN	denotes	Sam68
T7619	29489-29491	IN	denotes	in
T7620	29492-29499	NNS	denotes	neurons
T7621	29500-29501	-LRB-	denotes	[
T7622	29501-29503	CD	denotes	52
T7623	29503-29504	-RRB-	denotes	]
T7624	29505-29508	CC	denotes	and
T7625	29509-29511	IN	denotes	as
T7626	29512-29513	DT	denotes	a
T7627	29514-29523	NN	denotes	substrate
T7628	29524-29526	IN	denotes	of
T7629	29527-29530	DT	denotes	the
T7630	29559-29565	NN	denotes	kinase
T7631	29531-29541	JJ	denotes	intestinal
T7632	29542-29545	NN	denotes	SIK
T7633	29545-29546	HYPH	denotes	/
T7634	29546-29552	NN	denotes	breast
T7635	29553-29558	NN	denotes	tumor
T7636	29566-29567	-LRB-	denotes	[
T7637	29567-29569	CD	denotes	43
T7638	29569-29570	-RRB-	denotes	]
T7639	29570-29571	.	denotes	.
T7640	29571-29697	sentence	denotes	The expression of Sam68 was not altered in aging bone marrow stromal cells or in senescencing WI-38 cells (unpublished data).
T7641	29572-29575	DT	denotes	The
T7642	29576-29586	NN	denotes	expression
T7643	29604-29611	VBN	denotes	altered
T7644	29587-29589	IN	denotes	of
T7645	29590-29595	NN	denotes	Sam68
T7646	29596-29599	VBD	denotes	was
T7647	29600-29603	RB	denotes	not
T7648	29612-29614	IN	denotes	in
T7649	29615-29620	VBG	denotes	aging
T7650	29641-29646	NNS	denotes	cells
T7651	29621-29625	NN	denotes	bone
T7652	29626-29632	NN	denotes	marrow
T7653	29633-29640	JJ	denotes	stromal
T7654	29647-29649	CC	denotes	or
T7655	29650-29652	IN	denotes	in
T7656	29653-29665	VBG	denotes	senescencing
T7657	29672-29677	NNS	denotes	cells
T7658	29666-29668	NN	denotes	WI
T7659	29668-29669	HYPH	denotes	-
T7660	29669-29671	CD	denotes	38
T7661	29678-29679	-LRB-	denotes	(
T7662	29691-29695	NNS	denotes	data
T7663	29679-29690	JJ	denotes	unpublished
T7664	29695-29696	-RRB-	denotes	)
T7665	29696-29697	.	denotes	.
T7666	29697-29863	sentence	denotes	The presence of Sam68 in chondrocytes, osteoblasts and osteoclasts in developing cartilage and bone predicted a pivotal role for the protein in skeletal development.
T7667	29698-29701	DT	denotes	The
T7668	29702-29710	NN	denotes	presence
T7669	29798-29807	VBD	denotes	predicted
T7670	29711-29713	IN	denotes	of
T7671	29714-29719	NN	denotes	Sam68
T7672	29720-29722	IN	denotes	in
T7673	29723-29735	NNS	denotes	chondrocytes
T7674	29735-29737	,	denotes	,
T7675	29737-29748	NNS	denotes	osteoblasts
T7676	29749-29752	CC	denotes	and
T7677	29753-29764	NNS	denotes	osteoclasts
T7678	29765-29767	IN	denotes	in
T7679	29768-29778	VBG	denotes	developing
T7680	29779-29788	NN	denotes	cartilage
T7681	29789-29792	CC	denotes	and
T7682	29793-29797	NN	denotes	bone
T7683	29808-29809	DT	denotes	a
T7684	29818-29822	NN	denotes	role
T7685	29810-29817	JJ	denotes	pivotal
T7686	29823-29826	IN	denotes	for
T7687	29827-29830	DT	denotes	the
T7688	29831-29838	NN	denotes	protein
T7689	29839-29841	IN	denotes	in
T7690	29842-29850	JJ	denotes	skeletal
T7691	29851-29862	NN	denotes	development
T7692	29862-29863	.	denotes	.
T7693	29863-30075	sentence	denotes	The Sam68−/− mice were generated using a traditional targeting approach where the functional KH domain was deleted and approximately one third of the Sam68−/− mice survived to adulthood with no apparent defects.
T7694	29864-29867	DT	denotes	The
T7695	29877-29881	NNS	denotes	mice
T7696	29868-29873	NN	denotes	Sam68
T7697	29873-29874	SYM	denotes	−
T7698	29874-29875	HYPH	denotes	/
T7699	29875-29876	SYM	denotes	−
T7700	29887-29896	VBN	denotes	generated
T7701	29882-29886	VBD	denotes	were
T7702	29897-29902	VBG	denotes	using
T7703	29903-29904	DT	denotes	a
T7704	29927-29935	NN	denotes	approach
T7705	29905-29916	JJ	denotes	traditional
T7706	29917-29926	NN	denotes	targeting
T7707	29936-29941	WRB	denotes	where
T7708	29971-29978	VBN	denotes	deleted
T7709	29942-29945	DT	denotes	the
T7710	29960-29966	NN	denotes	domain
T7711	29946-29956	JJ	denotes	functional
T7712	29957-29959	NN	denotes	KH
T7713	29967-29970	VBD	denotes	was
T7714	29979-29982	CC	denotes	and
T7715	29983-29996	RB	denotes	approximately
T7716	29997-30000	CD	denotes	one
T7717	30028-30036	VBD	denotes	survived
T7718	30001-30006	JJ	denotes	third
T7719	30007-30009	IN	denotes	of
T7720	30010-30013	DT	denotes	the
T7721	30023-30027	NNS	denotes	mice
T7722	30014-30019	NN	denotes	Sam68
T7723	30019-30020	SYM	denotes	−
T7724	30020-30021	HYPH	denotes	/
T7725	30021-30022	SYM	denotes	−
T7726	30037-30039	IN	denotes	to
T7727	30040-30049	NN	denotes	adulthood
T7728	30050-30054	IN	denotes	with
T7729	30055-30057	DT	denotes	no
T7730	30067-30074	NNS	denotes	defects
T7731	30058-30066	JJ	denotes	apparent
T7732	30074-30075	.	denotes	.
T7733	30075-30234	sentence	denotes	One explanation for this phenomenon is that Sam68 function is sub-served by one or more of its family members during development such as SLM-1 and SLM-2 [47].
T7734	30076-30079	CD	denotes	One
T7735	30080-30091	NN	denotes	explanation
T7736	30112-30114	VBZ	denotes	is
T7737	30092-30095	IN	denotes	for
T7738	30096-30100	DT	denotes	this
T7739	30101-30111	NN	denotes	phenomenon
T7740	30115-30119	IN	denotes	that
T7741	30138-30148	VBN	denotes	sub-served
T7742	30120-30125	NN	denotes	Sam68
T7743	30126-30134	NN	denotes	function
T7744	30135-30137	VBZ	denotes	is
T7745	30149-30151	IN	denotes	by
T7746	30152-30155	CD	denotes	one
T7747	30156-30158	CC	denotes	or
T7748	30159-30163	JJR	denotes	more
T7749	30164-30166	IN	denotes	of
T7750	30167-30170	PRP$	denotes	its
T7751	30178-30185	NNS	denotes	members
T7752	30171-30177	NN	denotes	family
T7753	30186-30192	IN	denotes	during
T7754	30193-30204	NN	denotes	development
T7755	30205-30209	JJ	denotes	such
T7756	30210-30212	IN	denotes	as
T7757	30213-30216	NN	denotes	SLM
T7758	30216-30217	HYPH	denotes	-
T7759	30217-30218	CD	denotes	1
T7760	30219-30222	CC	denotes	and
T7761	30223-30226	NN	denotes	SLM
T7762	30226-30227	HYPH	denotes	-
T7763	30227-30228	CD	denotes	2
T7764	30229-30230	-LRB-	denotes	[
T7765	30230-30232	CD	denotes	47
T7766	30232-30233	-RRB-	denotes	]
T7767	30233-30234	.	denotes	.
T7768	30234-30301	sentence	denotes	Alternatively, Sam68 is not required during embryonic development.
T7769	30235-30248	RB	denotes	Alternatively
T7770	30263-30271	VBN	denotes	required
T7771	30248-30250	,	denotes	,
T7772	30250-30255	NN	denotes	Sam68
T7773	30256-30258	VBZ	denotes	is
T7774	30259-30262	RB	denotes	not
T7775	30272-30278	IN	denotes	during
T7776	30279-30288	JJ	denotes	embryonic
T7777	30289-30300	NN	denotes	development
T7778	30300-30301	.	denotes	.
T7779	30301-30404	sentence	denotes	However, two thirds of the Sam68−/−, but not the Sam68+/- pups, were killed by their Sam68+/- mothers.
T7780	30302-30309	RB	denotes	However
T7781	30371-30377	VBN	denotes	killed
T7782	30309-30311	,	denotes	,
T7783	30311-30314	CD	denotes	two
T7784	30315-30321	NNS	denotes	thirds
T7785	30322-30324	IN	denotes	of
T7786	30325-30328	DT	denotes	the
T7787	30329-30334	NN	denotes	Sam68
T7788	30334-30335	SYM	denotes	−
T7789	30335-30336	HYPH	denotes	/
T7790	30336-30337	SYM	denotes	−
T7791	30337-30339	,	denotes	,
T7792	30339-30342	CC	denotes	but
T7793	30343-30346	RB	denotes	not
T7794	30347-30350	DT	denotes	the
T7795	30351-30356	NN	denotes	Sam68
T7796	30360-30364	NNS	denotes	pups
T7797	30356-30357	SYM	denotes	+
T7798	30357-30358	HYPH	denotes	/
T7799	30358-30359	SYM	denotes	-
T7800	30364-30366	,	denotes	,
T7801	30366-30370	VBD	denotes	were
T7802	30378-30380	IN	denotes	by
T7803	30381-30386	PRP$	denotes	their
T7804	30396-30403	NNS	denotes	mothers
T7805	30387-30392	NN	denotes	Sam68
T7806	30392-30393	SYM	denotes	+
T7807	30393-30394	HYPH	denotes	/
T7808	30394-30395	SYM	denotes	-
T7809	30403-30404	.	denotes	.
T7810	30404-30506	sentence	denotes	These findings suggest that the mothers are able to detect a subtle defect/difference that we cannot.
T7811	30405-30410	DT	denotes	These
T7812	30411-30419	NNS	denotes	findings
T7813	30420-30427	VBP	denotes	suggest
T7814	30428-30432	IN	denotes	that
T7815	30445-30448	VBP	denotes	are
T7816	30433-30436	DT	denotes	the
T7817	30437-30444	NNS	denotes	mothers
T7818	30449-30453	JJ	denotes	able
T7819	30454-30456	TO	denotes	to
T7820	30457-30463	VB	denotes	detect
T7821	30464-30465	DT	denotes	a
T7822	30480-30490	NN	denotes	difference
T7823	30466-30472	JJ	denotes	subtle
T7824	30473-30479	NN	denotes	defect
T7825	30479-30480	HYPH	denotes	/
T7826	30491-30495	WDT	denotes	that
T7827	30499-30502	MD	denotes	can
T7828	30496-30498	PRP	denotes	we
T7829	30502-30505	RB	denotes	not
T7830	30505-30506	.	denotes	.
T7831	30506-30578	sentence	denotes	Adult Sam68−/− mice live a normal life span of approximately two years.
T7832	30507-30512	JJ	denotes	Adult
T7833	30522-30526	NNS	denotes	mice
T7834	30513-30518	NN	denotes	Sam68
T7835	30518-30519	SYM	denotes	−
T7836	30519-30520	HYPH	denotes	/
T7837	30520-30521	SYM	denotes	−
T7838	30527-30531	VBP	denotes	live
T7839	30532-30533	DT	denotes	a
T7840	30546-30550	NN	denotes	span
T7841	30534-30540	JJ	denotes	normal
T7842	30541-30545	NN	denotes	life
T7843	30551-30553	IN	denotes	of
T7844	30554-30567	RB	denotes	approximately
T7845	30568-30571	CD	denotes	two
T7846	30572-30577	NNS	denotes	years
T7847	30577-30578	.	denotes	.
T7848	30578-30758	sentence	denotes	The Sam68−/− males were sterile and the Sam68−/− females provided inadequate care to their young, but the pups were not scattered and neglected as observed with FosB−/− mice [53].
T7849	30579-30582	DT	denotes	The
T7850	30592-30597	NNS	denotes	males
T7851	30583-30588	NN	denotes	Sam68
T7852	30588-30589	SYM	denotes	−
T7853	30589-30590	HYPH	denotes	/
T7854	30590-30591	SYM	denotes	−
T7855	30598-30602	VBD	denotes	were
T7856	30603-30610	JJ	denotes	sterile
T7857	30611-30614	CC	denotes	and
T7858	30615-30618	DT	denotes	the
T7859	30628-30635	NNS	denotes	females
T7860	30619-30624	NN	denotes	Sam68
T7861	30624-30625	SYM	denotes	−
T7862	30625-30626	HYPH	denotes	/
T7863	30626-30627	SYM	denotes	−
T7864	30636-30644	VBD	denotes	provided
T7865	30645-30655	JJ	denotes	inadequate
T7866	30656-30660	NN	denotes	care
T7867	30661-30663	IN	denotes	to
T7868	30664-30669	PRP$	denotes	their
T7869	30670-30675	JJ	denotes	young
T7870	30675-30677	,	denotes	,
T7871	30677-30680	CC	denotes	but
T7872	30681-30684	DT	denotes	the
T7873	30685-30689	NNS	denotes	pups
T7874	30699-30708	VBN	denotes	scattered
T7875	30690-30694	VBD	denotes	were
T7876	30695-30698	RB	denotes	not
T7877	30709-30712	CC	denotes	and
T7878	30713-30722	VBN	denotes	neglected
T7879	30723-30725	IN	denotes	as
T7880	30726-30734	VBN	denotes	observed
T7881	30735-30739	IN	denotes	with
T7882	30740-30744	NN	denotes	FosB
T7883	30748-30752	NNS	denotes	mice
T7884	30744-30745	SYM	denotes	−
T7885	30745-30746	HYPH	denotes	/
T7886	30746-30747	SYM	denotes	−
T7887	30753-30754	-LRB-	denotes	[
T7888	30754-30756	CD	denotes	53
T7889	30756-30757	-RRB-	denotes	]
T7890	30757-30758	.	denotes	.
T7891	30758-30895	sentence	denotes	Serum levels of estrogen decreased in aging Sam68−/− females as expected; however, the leptin levels decreased in aged Sam68−/− females.
T7892	30759-30764	NN	denotes	Serum
T7893	30765-30771	NNS	denotes	levels
T7894	30784-30793	VBD	denotes	decreased
T7895	30772-30774	IN	denotes	of
T7896	30775-30783	NN	denotes	estrogen
T7897	30860-30869	VBD	denotes	decreased
T7898	30794-30796	IN	denotes	in
T7899	30797-30802	VBG	denotes	aging
T7900	30812-30819	NNS	denotes	females
T7901	30803-30808	NN	denotes	Sam68
T7902	30808-30809	SYM	denotes	−
T7903	30809-30810	HYPH	denotes	/
T7904	30810-30811	SYM	denotes	−
T7905	30820-30822	IN	denotes	as
T7906	30823-30831	VBN	denotes	expected
T7907	30831-30832	:	denotes	;
T7908	30833-30840	RB	denotes	however
T7909	30840-30842	,	denotes	,
T7910	30842-30845	DT	denotes	the
T7911	30853-30859	NNS	denotes	levels
T7912	30846-30852	NN	denotes	leptin
T7913	30870-30872	IN	denotes	in
T7914	30873-30877	JJ	denotes	aged
T7915	30887-30894	NNS	denotes	females
T7916	30878-30883	NN	denotes	Sam68
T7917	30883-30884	SYM	denotes	−
T7918	30884-30885	HYPH	denotes	/
T7919	30885-30886	SYM	denotes	−
T7920	30894-30895	.	denotes	.
T7921	30895-31006	sentence	denotes	The aged Sam68−/− females were not obese and actually weighed less than the littermate controls (see Table 2).
T7922	30896-30899	DT	denotes	The
T7923	30914-30921	NNS	denotes	females
T7924	30900-30904	JJ	denotes	aged
T7925	30905-30910	NN	denotes	Sam68
T7926	30910-30911	SYM	denotes	−
T7927	30911-30912	HYPH	denotes	/
T7928	30912-30913	SYM	denotes	−
T7929	30922-30926	VBD	denotes	were
T7930	30927-30930	RB	denotes	not
T7931	30931-30936	JJ	denotes	obese
T7932	30937-30940	CC	denotes	and
T7933	30941-30949	RB	denotes	actually
T7934	30950-30957	VBD	denotes	weighed
T7935	30958-30962	JJR	denotes	less
T7936	30963-30967	IN	denotes	than
T7937	30968-30971	DT	denotes	the
T7938	30983-30991	NNS	denotes	controls
T7939	30972-30982	NN	denotes	littermate
T7940	30992-30993	-LRB-	denotes	(
T7941	30993-30996	VB	denotes	see
T7942	30997-31002	NN	denotes	Table
T7943	31003-31004	CD	denotes	2
T7944	31004-31005	-RRB-	denotes	)
T7945	31005-31006	.	denotes	.
T7946	31006-31246	sentence	denotes	Moreover, their appetite was not altered with aging (N. Torabi and S. Richard, unpublished data), suggesting that the observed leptin reduction was not recreating ob/ob-like phenotypes related to weight, appetite and female sterility [54].
T7947	31007-31015	RB	denotes	Moreover
T7948	31040-31047	VBN	denotes	altered
T7949	31015-31017	,	denotes	,
T7950	31017-31022	PRP$	denotes	their
T7951	31023-31031	NN	denotes	appetite
T7952	31032-31035	VBD	denotes	was
T7953	31036-31039	RB	denotes	not
T7954	31048-31052	IN	denotes	with
T7955	31053-31058	NN	denotes	aging
T7956	31059-31060	-LRB-	denotes	(
T7957	31060-31062	NNP	denotes	N.
T7958	31063-31069	NNP	denotes	Torabi
T7959	31070-31073	CC	denotes	and
T7960	31074-31076	NNP	denotes	S.
T7961	31077-31084	NNP	denotes	Richard
T7962	31084-31086	,	denotes	,
T7963	31086-31097	JJ	denotes	unpublished
T7964	31098-31102	NNS	denotes	data
T7965	31102-31103	-RRB-	denotes	)
T7966	31103-31105	,	denotes	,
T7967	31105-31115	VBG	denotes	suggesting
T7968	31116-31120	IN	denotes	that
T7969	31159-31169	VBG	denotes	recreating
T7970	31121-31124	DT	denotes	the
T7971	31141-31150	NN	denotes	reduction
T7972	31125-31133	VBN	denotes	observed
T7973	31134-31140	NN	denotes	leptin
T7974	31151-31154	VBD	denotes	was
T7975	31155-31158	RB	denotes	not
T7976	31170-31172	NN	denotes	ob
T7977	31176-31180	JJ	denotes	like
T7978	31172-31173	HYPH	denotes	/
T7979	31173-31175	NN	denotes	ob
T7980	31175-31176	HYPH	denotes	-
T7981	31181-31191	NNS	denotes	phenotypes
T7982	31192-31199	VBN	denotes	related
T7983	31200-31202	IN	denotes	to
T7984	31203-31209	NN	denotes	weight
T7985	31209-31211	,	denotes	,
T7986	31211-31219	NN	denotes	appetite
T7987	31220-31223	CC	denotes	and
T7988	31224-31230	JJ	denotes	female
T7989	31231-31240	NN	denotes	sterility
T7990	31241-31242	-LRB-	denotes	[
T7991	31242-31244	CD	denotes	54
T7992	31244-31245	-RRB-	denotes	]
T7993	31245-31246	.	denotes	.
T7994	31246-31371	sentence	denotes	The skeletal phenotyping of cohorts of Sam68+/+ and Sam68−/− mice showed that bone mass was preserved in aged Sam68−/− mice.
T7995	31247-31250	DT	denotes	The
T7996	31260-31271	NN	denotes	phenotyping
T7997	31251-31259	JJ	denotes	skeletal
T7998	31313-31319	VBD	denotes	showed
T7999	31272-31274	IN	denotes	of
T8000	31275-31282	NNS	denotes	cohorts
T8001	31283-31285	IN	denotes	of
T8002	31286-31291	NN	denotes	Sam68
T8003	31308-31312	NNS	denotes	mice
T8004	31291-31292	SYM	denotes	+
T8005	31292-31293	HYPH	denotes	/
T8006	31293-31294	SYM	denotes	+
T8007	31295-31298	CC	denotes	and
T8008	31299-31304	NN	denotes	Sam68
T8009	31304-31305	SYM	denotes	−
T8010	31305-31306	HYPH	denotes	/
T8011	31306-31307	SYM	denotes	−
T8012	31320-31324	IN	denotes	that
T8013	31339-31348	VBN	denotes	preserved
T8014	31325-31329	NN	denotes	bone
T8015	31330-31334	NN	denotes	mass
T8016	31335-31338	VBD	denotes	was
T8017	31349-31351	IN	denotes	in
T8018	31352-31356	JJ	denotes	aged
T8019	31366-31370	NNS	denotes	mice
T8020	31357-31362	NN	denotes	Sam68
T8021	31362-31363	SYM	denotes	−
T8022	31363-31364	HYPH	denotes	/
T8023	31364-31365	SYM	denotes	−
T8024	31370-31371	.	denotes	.
T8025	31371-31504	sentence	denotes	Traditional histology and histomorphometry suggested that the mechanism involved preservation of osteoblast and osteoclast activity.
T8026	31372-31383	JJ	denotes	Traditional
T8027	31384-31393	NN	denotes	histology
T8028	31415-31424	VBD	denotes	suggested
T8029	31394-31397	CC	denotes	and
T8030	31398-31414	NN	denotes	histomorphometry
T8031	31425-31429	IN	denotes	that
T8032	31444-31452	VBD	denotes	involved
T8033	31430-31433	DT	denotes	the
T8034	31434-31443	NN	denotes	mechanism
T8035	31453-31465	NN	denotes	preservation
T8036	31466-31468	IN	denotes	of
T8037	31469-31479	NN	denotes	osteoblast
T8038	31495-31503	NN	denotes	activity
T8039	31480-31483	CC	denotes	and
T8040	31484-31494	NN	denotes	osteoclast
T8041	31503-31504	DT	denotes	.
T8042	31504-31662	sentence	denotes	The documented role of the Sam68 regulatory protein, Src, in osteopetrosis led us to investigate the morphology and activity of Sam68−/− osteoclasts ex vivo.
T8043	31505-31508	DT	denotes	The
T8044	31520-31524	NN	denotes	role
T8045	31509-31519	VBN	denotes	documented
T8046	31580-31583	VBD	denotes	led
T8047	31525-31527	IN	denotes	of
T8048	31528-31531	DT	denotes	the
T8049	31549-31556	NN	denotes	protein
T8050	31532-31537	NN	denotes	Sam68
T8051	31538-31548	JJ	denotes	regulatory
T8052	31556-31558	,	denotes	,
T8053	31558-31561	NN	denotes	Src
T8054	31561-31563	,	denotes	,
T8055	31563-31565	IN	denotes	in
T8056	31566-31579	NN	denotes	osteopetrosis
T8057	31584-31586	PRP	denotes	us
T8058	31587-31589	TO	denotes	to
T8059	31590-31601	VB	denotes	investigate
T8060	31602-31605	DT	denotes	the
T8061	31606-31616	NN	denotes	morphology
T8062	31617-31620	CC	denotes	and
T8063	31621-31629	NN	denotes	activity
T8064	31630-31632	IN	denotes	of
T8065	31633-31638	NN	denotes	Sam68
T8066	31642-31653	NNS	denotes	osteoclasts
T8067	31638-31639	SYM	denotes	−
T8068	31639-31640	HYPH	denotes	/
T8069	31640-31641	SYM	denotes	−
T8070	31654-31656	FW	denotes	ex
T8071	31657-31661	FW	denotes	vivo
T8072	31661-31662	.	denotes	.
T8073	31662-31880	sentence	denotes	The Src tyrosine kinase was shown to play a role in bone remodeling when Src−/− mice died at 6 months of age with an osteopetrotic phenotype [48] and the defect was attributed to defective osteoclast function [55−59].
T8074	31663-31666	DT	denotes	The
T8075	31680-31686	NN	denotes	kinase
T8076	31667-31670	NN	denotes	Src
T8077	31671-31679	NN	denotes	tyrosine
T8078	31691-31696	VBN	denotes	shown
T8079	31687-31690	VBD	denotes	was
T8080	31697-31699	TO	denotes	to
T8081	31700-31704	VB	denotes	play
T8082	31705-31706	DT	denotes	a
T8083	31707-31711	NN	denotes	role
T8084	31712-31714	IN	denotes	in
T8085	31715-31719	NN	denotes	bone
T8086	31720-31730	NN	denotes	remodeling
T8087	31731-31735	WRB	denotes	when
T8088	31748-31752	VBD	denotes	died
T8089	31736-31739	NN	denotes	Src
T8090	31743-31747	NNS	denotes	mice
T8091	31739-31740	SYM	denotes	−
T8092	31740-31741	HYPH	denotes	/
T8093	31741-31742	SYM	denotes	−
T8094	31753-31755	IN	denotes	at
T8095	31756-31757	CD	denotes	6
T8096	31758-31764	NNS	denotes	months
T8097	31765-31767	IN	denotes	of
T8098	31768-31771	NN	denotes	age
T8099	31772-31776	IN	denotes	with
T8100	31777-31779	DT	denotes	an
T8101	31794-31803	NN	denotes	phenotype
T8102	31780-31793	JJ	denotes	osteopetrotic
T8103	31804-31805	-LRB-	denotes	[
T8104	31805-31807	CD	denotes	48
T8105	31807-31808	-RRB-	denotes	]
T8106	31809-31812	CC	denotes	and
T8107	31813-31816	DT	denotes	the
T8108	31817-31823	NN	denotes	defect
T8109	31828-31838	VBN	denotes	attributed
T8110	31824-31827	VBD	denotes	was
T8111	31839-31841	IN	denotes	to
T8112	31842-31851	JJ	denotes	defective
T8113	31863-31871	NN	denotes	function
T8114	31852-31862	NN	denotes	osteoclast
T8115	31872-31873	-LRB-	denotes	[
T8116	31873-31875	CD	denotes	55
T8117	31875-31876	SYM	denotes	−
T8118	31876-31878	CD	denotes	59
T8119	31878-31879	-RRB-	denotes	]
T8120	31879-31880	.	denotes	.
T8121	31880-32027	sentence	denotes	We therefore cultured mature osteoclasts harvested from Sam68+/+ and Sam68−/− mice ex vivo on dentin slices to quantify their resorptive capacity.
T8122	31881-31883	PRP	denotes	We
T8123	31894-31902	VBD	denotes	cultured
T8124	31884-31893	RB	denotes	therefore
T8125	31903-31909	JJ	denotes	mature
T8126	31910-31921	NNS	denotes	osteoclasts
T8127	31922-31931	VBN	denotes	harvested
T8128	31932-31936	IN	denotes	from
T8129	31937-31942	NN	denotes	Sam68
T8130	31959-31963	NNS	denotes	mice
T8131	31942-31943	SYM	denotes	+
T8132	31943-31944	HYPH	denotes	/
T8133	31944-31945	SYM	denotes	+
T8134	31946-31949	CC	denotes	and
T8135	31950-31955	NN	denotes	Sam68
T8136	31955-31956	SYM	denotes	−
T8137	31956-31957	HYPH	denotes	/
T8138	31957-31958	SYM	denotes	−
T8139	31964-31966	FW	denotes	ex
T8140	31967-31971	FW	denotes	vivo
T8141	31972-31974	IN	denotes	on
T8142	31975-31981	NN	denotes	dentin
T8143	31982-31988	NNS	denotes	slices
T8144	31989-31991	TO	denotes	to
T8145	31992-32000	VB	denotes	quantify
T8146	32001-32006	PRP$	denotes	their
T8147	32018-32026	NN	denotes	capacity
T8148	32007-32017	JJ	denotes	resorptive
T8149	32026-32027	.	denotes	.
T8150	32027-32243	sentence	denotes	The fact that Sam68−/− osteoclasts looked and acted like Sam68+/+ osteoclasts ex vivo and in vivo made it unlikely that this was the primary source of the difference in bone metabolism in 12-month-old Sam68−/− mice.
T8151	32028-32031	DT	denotes	The
T8152	32032-32036	NN	denotes	fact
T8153	32126-32130	VBD	denotes	made
T8154	32037-32041	IN	denotes	that
T8155	32063-32069	VBD	denotes	looked
T8156	32042-32047	NN	denotes	Sam68
T8157	32051-32062	NNS	denotes	osteoclasts
T8158	32047-32048	SYM	denotes	−
T8159	32048-32049	HYPH	denotes	/
T8160	32049-32050	SYM	denotes	−
T8161	32070-32073	CC	denotes	and
T8162	32074-32079	VBD	denotes	acted
T8163	32080-32084	IN	denotes	like
T8164	32085-32090	NN	denotes	Sam68
T8165	32094-32105	NNS	denotes	osteoclasts
T8166	32090-32091	SYM	denotes	+
T8167	32091-32092	HYPH	denotes	/
T8168	32092-32093	SYM	denotes	+
T8169	32106-32108	FW	denotes	ex
T8170	32109-32113	FW	denotes	vivo
T8171	32114-32117	CC	denotes	and
T8172	32118-32120	FW	denotes	in
T8173	32121-32125	FW	denotes	vivo
T8174	32131-32133	PRP	denotes	it
T8175	32134-32142	JJ	denotes	unlikely
T8176	32143-32147	IN	denotes	that
T8177	32153-32156	VBD	denotes	was
T8178	32148-32152	DT	denotes	this
T8179	32157-32160	DT	denotes	the
T8180	32169-32175	NN	denotes	source
T8181	32161-32168	JJ	denotes	primary
T8182	32176-32178	IN	denotes	of
T8183	32179-32182	DT	denotes	the
T8184	32183-32193	NN	denotes	difference
T8185	32194-32196	IN	denotes	in
T8186	32197-32201	NN	denotes	bone
T8187	32202-32212	NN	denotes	metabolism
T8188	32213-32215	IN	denotes	in
T8189	32216-32218	CD	denotes	12
T8190	32219-32224	NN	denotes	month
T8191	32218-32219	HYPH	denotes	-
T8192	32225-32228	JJ	denotes	old
T8193	32224-32225	HYPH	denotes	-
T8194	32238-32242	NNS	denotes	mice
T8195	32229-32234	NN	denotes	Sam68
T8196	32234-32235	SYM	denotes	−
T8197	32235-32236	HYPH	denotes	/
T8198	32236-32237	SYM	denotes	−
T8199	32242-32243	.	denotes	.
T8200	32243-32407	sentence	denotes	The fact that the CTX levels were lower in young and old Sam68−/− mice suggested that there is reduced bone resorption compared with wild-type littermate controls.
T8201	32244-32247	DT	denotes	The
T8202	32248-32252	NN	denotes	fact
T8203	32315-32324	VBD	denotes	suggested
T8204	32253-32257	IN	denotes	that
T8205	32273-32277	VBD	denotes	were
T8206	32258-32261	DT	denotes	the
T8207	32266-32272	NNS	denotes	levels
T8208	32262-32265	NN	denotes	CTX
T8209	32278-32283	JJR	denotes	lower
T8210	32284-32286	IN	denotes	in
T8211	32287-32292	JJ	denotes	young
T8212	32310-32314	NNS	denotes	mice
T8213	32293-32296	CC	denotes	and
T8214	32297-32300	JJ	denotes	old
T8215	32301-32306	NN	denotes	Sam68
T8216	32306-32307	SYM	denotes	−
T8217	32307-32308	HYPH	denotes	/
T8218	32308-32309	SYM	denotes	−
T8219	32325-32329	IN	denotes	that
T8220	32336-32338	VBZ	denotes	is
T8221	32330-32335	EX	denotes	there
T8222	32339-32346	VBN	denotes	reduced
T8223	32352-32362	NN	denotes	resorption
T8224	32347-32351	NN	denotes	bone
T8225	32363-32371	VBN	denotes	compared
T8226	32372-32376	IN	denotes	with
T8227	32377-32381	JJ	denotes	wild
T8228	32382-32386	NN	denotes	type
T8229	32381-32382	HYPH	denotes	-
T8230	32398-32406	NNS	denotes	controls
T8231	32387-32397	NN	denotes	littermate
T8232	32406-32407	.	denotes	.
T8233	32407-32527	sentence	denotes	However, this reduction in bone resorption occurred with normal osteoclast activity, as assessed by in vitro culturing.
T8234	32408-32415	RB	denotes	However
T8235	32451-32459	VBD	denotes	occurred
T8236	32415-32417	,	denotes	,
T8237	32417-32421	DT	denotes	this
T8238	32422-32431	NN	denotes	reduction
T8239	32432-32434	IN	denotes	in
T8240	32435-32439	NN	denotes	bone
T8241	32440-32450	NN	denotes	resorption
T8242	32460-32464	IN	denotes	with
T8243	32465-32471	JJ	denotes	normal
T8244	32483-32491	NN	denotes	activity
T8245	32472-32482	NN	denotes	osteoclast
T8246	32491-32493	,	denotes	,
T8247	32493-32495	IN	denotes	as
T8248	32496-32504	VBN	denotes	assessed
T8249	32505-32507	IN	denotes	by
T8250	32508-32510	FW	denotes	in
T8251	32511-32516	FW	denotes	vitro
T8252	32517-32526	NN	denotes	culturing
T8253	32526-32527	.	denotes	.
T8254	32527-32620	sentence	denotes	These observations are consistent with the Sam68−/− mice having a youth-like bone phenotype.
T8255	32528-32533	DT	denotes	These
T8256	32534-32546	NNS	denotes	observations
T8257	32547-32550	VBP	denotes	are
T8258	32551-32561	JJ	denotes	consistent
T8259	32562-32566	IN	denotes	with
T8260	32567-32570	DT	denotes	the
T8261	32580-32584	NNS	denotes	mice
T8262	32571-32576	NN	denotes	Sam68
T8263	32576-32577	SYM	denotes	−
T8264	32577-32578	HYPH	denotes	/
T8265	32578-32579	SYM	denotes	−
T8266	32585-32591	VBG	denotes	having
T8267	32592-32593	DT	denotes	a
T8268	32610-32619	NN	denotes	phenotype
T8269	32594-32599	NN	denotes	youth
T8270	32600-32604	JJ	denotes	like
T8271	32599-32600	HYPH	denotes	-
T8272	32605-32609	NN	denotes	bone
T8273	32619-32620	.	denotes	.
T8274	32620-32825	sentence	denotes	However, it is still possible, that a mild impairment in Sam68−/− mice osteoclast function may manifest itself later in life in overall accumulation of bone and this will require further detailed studies.
T8275	32621-32628	RB	denotes	However
T8276	32633-32635	VBZ	denotes	is
T8277	32628-32630	,	denotes	,
T8278	32630-32632	PRP	denotes	it
T8279	32636-32641	RB	denotes	still
T8280	32642-32650	JJ	denotes	possible
T8281	32650-32652	,	denotes	,
T8282	32652-32656	IN	denotes	that
T8283	32716-32724	VB	denotes	manifest
T8284	32657-32658	DT	denotes	a
T8285	32664-32674	NN	denotes	impairment
T8286	32659-32663	JJ	denotes	mild
T8287	32675-32677	IN	denotes	in
T8288	32678-32683	NN	denotes	Sam68
T8289	32687-32691	NNS	denotes	mice
T8290	32683-32684	SYM	denotes	−
T8291	32684-32685	HYPH	denotes	/
T8292	32685-32686	SYM	denotes	−
T8293	32703-32711	NN	denotes	function
T8294	32692-32702	NN	denotes	osteoclast
T8295	32712-32715	MD	denotes	may
T8296	32725-32731	PRP	denotes	itself
T8297	32732-32737	RB	denotes	later
T8298	32738-32740	IN	denotes	in
T8299	32741-32745	NN	denotes	life
T8300	32746-32748	IN	denotes	in
T8301	32749-32756	JJ	denotes	overall
T8302	32757-32769	NN	denotes	accumulation
T8303	32770-32772	IN	denotes	of
T8304	32773-32777	NN	denotes	bone
T8305	32778-32781	CC	denotes	and
T8306	32782-32786	DT	denotes	this
T8307	32792-32799	VB	denotes	require
T8308	32787-32791	MD	denotes	will
T8309	32800-32807	JJ	denotes	further
T8310	32817-32824	NNS	denotes	studies
T8311	32808-32816	JJ	denotes	detailed
T8312	32824-32825	.	denotes	.
T8313	32825-33048	sentence	denotes	Ex vivo differentiation of primary bone marrow stromal cells, harvested from Sam68+/+ and Sam68−/− mice, down the osteoblast lineage revealed an osteogenic advantage in the cultures of cells derived from the Sam68−/− mice.
T8314	32826-32828	FW	denotes	Ex
T8315	32829-32833	FW	denotes	vivo
T8316	32834-32849	NN	denotes	differentiation
T8317	32959-32967	VBD	denotes	revealed
T8318	32850-32852	IN	denotes	of
T8319	32853-32860	JJ	denotes	primary
T8320	32881-32886	NNS	denotes	cells
T8321	32861-32865	NN	denotes	bone
T8322	32866-32872	NN	denotes	marrow
T8323	32873-32880	JJ	denotes	stromal
T8324	32886-32888	,	denotes	,
T8325	32888-32897	VBN	denotes	harvested
T8326	32898-32902	IN	denotes	from
T8327	32903-32908	NN	denotes	Sam68
T8328	32925-32929	NNS	denotes	mice
T8329	32908-32909	SYM	denotes	+
T8330	32909-32910	HYPH	denotes	/
T8331	32910-32911	SYM	denotes	+
T8332	32912-32915	CC	denotes	and
T8333	32916-32921	NN	denotes	Sam68
T8334	32921-32922	SYM	denotes	−
T8335	32922-32923	HYPH	denotes	/
T8336	32923-32924	SYM	denotes	−
T8337	32929-32931	,	denotes	,
T8338	32931-32935	IN	denotes	down
T8339	32936-32939	DT	denotes	the
T8340	32951-32958	NN	denotes	lineage
T8341	32940-32950	NN	denotes	osteoblast
T8342	32968-32970	DT	denotes	an
T8343	32982-32991	NN	denotes	advantage
T8344	32971-32981	JJ	denotes	osteogenic
T8345	32992-32994	IN	denotes	in
T8346	32995-32998	DT	denotes	the
T8347	32999-33007	NNS	denotes	cultures
T8348	33008-33010	IN	denotes	of
T8349	33011-33016	NNS	denotes	cells
T8350	33017-33024	VBN	denotes	derived
T8351	33025-33029	IN	denotes	from
T8352	33030-33033	DT	denotes	the
T8353	33043-33047	NNS	denotes	mice
T8354	33034-33039	NN	denotes	Sam68
T8355	33039-33040	SYM	denotes	−
T8356	33040-33041	HYPH	denotes	/
T8357	33041-33042	SYM	denotes	−
T8358	33047-33048	.	denotes	.
T8359	33048-33183	sentence	denotes	It will be important to demonstrate that a similar effect is observed using primary bone marrow stromal cells from aged Sam68−/− mice.
T8360	33049-33051	PRP	denotes	It
T8361	33057-33059	VB	denotes	be
T8362	33052-33056	MD	denotes	will
T8363	33060-33069	JJ	denotes	important
T8364	33070-33072	TO	denotes	to
T8365	33073-33084	VB	denotes	demonstrate
T8366	33085-33089	IN	denotes	that
T8367	33110-33118	VBN	denotes	observed
T8368	33090-33091	DT	denotes	a
T8369	33100-33106	NN	denotes	effect
T8370	33092-33099	JJ	denotes	similar
T8371	33107-33109	VBZ	denotes	is
T8372	33119-33124	VBG	denotes	using
T8373	33125-33132	JJ	denotes	primary
T8374	33153-33158	NNS	denotes	cells
T8375	33133-33137	NN	denotes	bone
T8376	33138-33144	NN	denotes	marrow
T8377	33145-33152	JJ	denotes	stromal
T8378	33159-33163	IN	denotes	from
T8379	33164-33168	JJ	denotes	aged
T8380	33178-33182	NNS	denotes	mice
T8381	33169-33174	NN	denotes	Sam68
T8382	33174-33175	SYM	denotes	−
T8383	33175-33176	HYPH	denotes	/
T8384	33176-33177	SYM	denotes	−
T8385	33182-33183	.	denotes	.
T8386	33183-33357	sentence	denotes	Similar findings were observed when embryonic mesenchymal multipotential progenitor cells C3H10T1/2 treated with Sam68 shRNA, were differentiated into osteoblasts with BMP2.
T8387	33184-33191	JJ	denotes	Similar
T8388	33192-33200	NNS	denotes	findings
T8389	33206-33214	VBN	denotes	observed
T8390	33201-33205	VBD	denotes	were
T8391	33215-33219	WRB	denotes	when
T8392	33315-33329	VBN	denotes	differentiated
T8393	33220-33229	JJ	denotes	embryonic
T8394	33268-33273	NNS	denotes	cells
T8395	33230-33241	JJ	denotes	mesenchymal
T8396	33242-33256	JJ	denotes	multipotential
T8397	33257-33267	NN	denotes	progenitor
T8398	33274-33281	NN	denotes	C3H10T1
T8399	33281-33282	HYPH	denotes	/
T8400	33282-33283	CD	denotes	2
T8401	33284-33291	VBN	denotes	treated
T8402	33292-33296	IN	denotes	with
T8403	33297-33302	NN	denotes	Sam68
T8404	33303-33308	NN	denotes	shRNA
T8405	33308-33310	,	denotes	,
T8406	33310-33314	VBD	denotes	were
T8407	33330-33334	IN	denotes	into
T8408	33335-33346	NNS	denotes	osteoblasts
T8409	33347-33351	IN	denotes	with
T8410	33352-33356	NN	denotes	BMP2
T8411	33356-33357	.	denotes	.
T8412	33357-33587	sentence	denotes	Our findings that aged Sam68−/− mice do not develop fatty bone marrow and that MEFs derived from Sam68 −/− mice have impaired adipocyte differentiation, indicate that Sam68 regulates both adipocyte and osteoblast differentiation.
T8413	33358-33361	PRP$	denotes	Our
T8414	33362-33370	NNS	denotes	findings
T8415	33511-33519	VBP	denotes	indicate
T8416	33371-33375	IN	denotes	that
T8417	33402-33409	VB	denotes	develop
T8418	33376-33380	JJ	denotes	aged
T8419	33390-33394	NNS	denotes	mice
T8420	33381-33386	NN	denotes	Sam68
T8421	33386-33387	SYM	denotes	−
T8422	33387-33388	HYPH	denotes	/
T8423	33388-33389	SYM	denotes	−
T8424	33395-33397	VBP	denotes	do
T8425	33398-33401	RB	denotes	not
T8426	33410-33415	JJ	denotes	fatty
T8427	33421-33427	NN	denotes	marrow
T8428	33416-33420	NN	denotes	bone
T8429	33428-33431	CC	denotes	and
T8430	33432-33436	IN	denotes	that
T8431	33470-33474	VBP	denotes	have
T8432	33437-33441	NNS	denotes	MEFs
T8433	33442-33449	VBN	denotes	derived
T8434	33450-33454	IN	denotes	from
T8435	33455-33460	NN	denotes	Sam68
T8436	33465-33469	NNS	denotes	mice
T8437	33461-33462	SYM	denotes	−
T8438	33462-33463	HYPH	denotes	/
T8439	33463-33464	SYM	denotes	−
T8440	33475-33483	VBN	denotes	impaired
T8441	33494-33509	NN	denotes	differentiation
T8442	33484-33493	NN	denotes	adipocyte
T8443	33509-33511	,	denotes	,
T8444	33520-33524	IN	denotes	that
T8445	33531-33540	VBZ	denotes	regulates
T8446	33525-33530	NN	denotes	Sam68
T8447	33541-33545	CC	denotes	both
T8448	33546-33555	NN	denotes	adipocyte
T8449	33571-33586	NN	denotes	differentiation
T8450	33556-33559	CC	denotes	and
T8451	33560-33570	NN	denotes	osteoblast
T8452	33586-33587	.	denotes	.
T8453	33587-33797	sentence	denotes	These findings identify Sam68 as the first RNA binding protein to regulate mesenchymal cell differentiation and the challenge will be to identify the specific RNA targets that it regulates during this process.
T8454	33588-33593	DT	denotes	These
T8455	33594-33602	NNS	denotes	findings
T8456	33603-33611	VBP	denotes	identify
T8457	33612-33617	NN	denotes	Sam68
T8458	33618-33620	IN	denotes	as
T8459	33621-33624	DT	denotes	the
T8460	33643-33650	NN	denotes	protein
T8461	33625-33630	JJ	denotes	first
T8462	33631-33634	NN	denotes	RNA
T8463	33635-33642	VBG	denotes	binding
T8464	33651-33653	TO	denotes	to
T8465	33654-33662	VB	denotes	regulate
T8466	33663-33674	JJ	denotes	mesenchymal
T8467	33680-33695	NN	denotes	differentiation
T8468	33675-33679	NN	denotes	cell
T8469	33696-33699	CC	denotes	and
T8470	33700-33703	DT	denotes	the
T8471	33704-33713	NN	denotes	challenge
T8472	33719-33721	VB	denotes	be
T8473	33714-33718	MD	denotes	will
T8474	33722-33724	TO	denotes	to
T8475	33725-33733	VB	denotes	identify
T8476	33734-33737	DT	denotes	the
T8477	33751-33758	NNS	denotes	targets
T8478	33738-33746	JJ	denotes	specific
T8479	33747-33750	NN	denotes	RNA
T8480	33759-33763	WDT	denotes	that
T8481	33767-33776	VBZ	denotes	regulates
T8482	33764-33766	PRP	denotes	it
T8483	33777-33783	IN	denotes	during
T8484	33784-33788	DT	denotes	this
T8485	33789-33796	NN	denotes	process
T8486	33796-33797	.	denotes	.
T8487	33797-33983	sentence	denotes	The fact that osteoblast function is altered in Src−/− mice [60,61] raises the possibility that preservation of bone mass in the Sam68−/− mice could be linked with and regulated by Src.
T8488	33798-33801	DT	denotes	The
T8489	33802-33806	NN	denotes	fact
T8490	33866-33872	VBZ	denotes	raises
T8491	33807-33811	IN	denotes	that
T8492	33835-33842	VBN	denotes	altered
T8493	33812-33822	NN	denotes	osteoblast
T8494	33823-33831	NN	denotes	function
T8495	33832-33834	VBZ	denotes	is
T8496	33843-33845	IN	denotes	in
T8497	33846-33849	NN	denotes	Src
T8498	33853-33857	NNS	denotes	mice
T8499	33849-33850	SYM	denotes	−
T8500	33850-33851	HYPH	denotes	/
T8501	33851-33852	SYM	denotes	−
T8502	33858-33859	-LRB-	denotes	[
T8503	33862-33864	CD	denotes	61
T8504	33859-33861	CD	denotes	60
T8505	33861-33862	,	denotes	,
T8506	33864-33865	-RRB-	denotes	]
T8507	33873-33876	DT	denotes	the
T8508	33877-33888	NN	denotes	possibility
T8509	33889-33893	IN	denotes	that
T8510	33950-33956	VBN	denotes	linked
T8511	33894-33906	NN	denotes	preservation
T8512	33907-33909	IN	denotes	of
T8513	33910-33914	NN	denotes	bone
T8514	33915-33919	NN	denotes	mass
T8515	33920-33922	IN	denotes	in
T8516	33923-33926	DT	denotes	the
T8517	33936-33940	NNS	denotes	mice
T8518	33927-33932	NN	denotes	Sam68
T8519	33932-33933	SYM	denotes	−
T8520	33933-33934	HYPH	denotes	/
T8521	33934-33935	SYM	denotes	−
T8522	33941-33946	MD	denotes	could
T8523	33947-33949	VB	denotes	be
T8524	33957-33961	IN	denotes	with
T8525	33962-33965	CC	denotes	and
T8526	33966-33975	VBN	denotes	regulated
T8527	33976-33978	IN	denotes	by
T8528	33979-33982	NN	denotes	Src
T8529	33982-33983	.	denotes	.
T8530	33983-34257	sentence	denotes	The pathway by which leptin regulates bone resorption was identified to involve the sympathetic nervous system relaying to the osteoblasts via the β-adrenergic pathway leading to the release of growth factors including RANKL that causes the osteoclasts to thrive [8,18–20].
T8531	33984-33987	DT	denotes	The
T8532	33988-33995	NN	denotes	pathway
T8533	34042-34052	VBN	denotes	identified
T8534	33996-33998	IN	denotes	by
T8535	34012-34021	VBZ	denotes	regulates
T8536	33999-34004	WDT	denotes	which
T8537	34005-34011	NN	denotes	leptin
T8538	34022-34026	NN	denotes	bone
T8539	34027-34037	NN	denotes	resorption
T8540	34038-34041	VBD	denotes	was
T8541	34053-34055	TO	denotes	to
T8542	34056-34063	VB	denotes	involve
T8543	34064-34067	DT	denotes	the
T8544	34088-34094	NN	denotes	system
T8545	34068-34079	JJ	denotes	sympathetic
T8546	34080-34087	JJ	denotes	nervous
T8547	34095-34103	VBG	denotes	relaying
T8548	34104-34106	IN	denotes	to
T8549	34107-34110	DT	denotes	the
T8550	34111-34122	NNS	denotes	osteoblasts
T8551	34123-34126	IN	denotes	via
T8552	34127-34130	DT	denotes	the
T8553	34144-34151	NN	denotes	pathway
T8554	34131-34132	NN	denotes	β
T8555	34133-34143	JJ	denotes	adrenergic
T8556	34132-34133	HYPH	denotes	-
T8557	34152-34159	VBG	denotes	leading
T8558	34160-34162	IN	denotes	to
T8559	34163-34166	DT	denotes	the
T8560	34167-34174	NN	denotes	release
T8561	34175-34177	IN	denotes	of
T8562	34178-34184	NN	denotes	growth
T8563	34185-34192	NNS	denotes	factors
T8564	34193-34202	VBG	denotes	including
T8565	34203-34208	NN	denotes	RANKL
T8566	34209-34213	WDT	denotes	that
T8567	34214-34220	VBZ	denotes	causes
T8568	34221-34224	DT	denotes	the
T8569	34225-34236	NNS	denotes	osteoclasts
T8570	34240-34246	VB	denotes	thrive
T8571	34237-34239	TO	denotes	to
T8572	34247-34248	-LRB-	denotes	[
T8573	34248-34249	CD	denotes	8
T8574	34249-34250	,	denotes	,
T8575	34250-34252	CD	denotes	18
T8576	34252-34253	SYM	denotes	–
T8577	34253-34255	CD	denotes	20
T8578	34255-34256	-RRB-	denotes	]
T8579	34256-34257	.	denotes	.
T8580	34257-34401	sentence	denotes	The lowering of leptin levels in aged Sam68−/− mice is consistent with these mice having a high bone mass compared with their aged littermates.
T8581	34258-34261	DT	denotes	The
T8582	34262-34270	NN	denotes	lowering
T8583	34310-34312	VBZ	denotes	is
T8584	34271-34273	IN	denotes	of
T8585	34274-34280	NN	denotes	leptin
T8586	34281-34287	NNS	denotes	levels
T8587	34288-34290	IN	denotes	in
T8588	34291-34295	JJ	denotes	aged
T8589	34305-34309	NNS	denotes	mice
T8590	34296-34301	NN	denotes	Sam68
T8591	34301-34302	SYM	denotes	−
T8592	34302-34303	HYPH	denotes	/
T8593	34303-34304	SYM	denotes	−
T8594	34313-34323	JJ	denotes	consistent
T8595	34324-34328	IN	denotes	with
T8596	34329-34334	DT	denotes	these
T8597	34335-34339	NNS	denotes	mice
T8598	34340-34346	VBG	denotes	having
T8599	34347-34348	DT	denotes	a
T8600	34359-34363	NN	denotes	mass
T8601	34349-34353	JJ	denotes	high
T8602	34354-34358	NN	denotes	bone
T8603	34364-34372	VBN	denotes	compared
T8604	34373-34377	IN	denotes	with
T8605	34378-34383	PRP$	denotes	their
T8606	34389-34400	NNS	denotes	littermates
T8607	34384-34388	JJ	denotes	aged
T8608	34400-34401	.	denotes	.
T8609	34401-34591	sentence	denotes	These data would suggest that the leptin-sympathetic pathway is unaltered in Sam68−/− mice and that the lowering of leptin may explain the lower levels of CTX in the serum of Sam68−/− mice.
T8610	34402-34407	DT	denotes	These
T8611	34408-34412	NNS	denotes	data
T8612	34419-34426	VB	denotes	suggest
T8613	34413-34418	MD	denotes	would
T8614	34427-34431	IN	denotes	that
T8615	34463-34465	VBZ	denotes	is
T8616	34432-34435	DT	denotes	the
T8617	34455-34462	NN	denotes	pathway
T8618	34436-34442	NN	denotes	leptin
T8619	34443-34454	JJ	denotes	sympathetic
T8620	34442-34443	HYPH	denotes	-
T8621	34466-34475	JJ	denotes	unaltered
T8622	34476-34478	IN	denotes	in
T8623	34479-34484	NN	denotes	Sam68
T8624	34488-34492	NNS	denotes	mice
T8625	34484-34485	SYM	denotes	−
T8626	34485-34486	HYPH	denotes	/
T8627	34486-34487	SYM	denotes	−
T8628	34493-34496	CC	denotes	and
T8629	34497-34501	IN	denotes	that
T8630	34529-34536	VB	denotes	explain
T8631	34502-34505	DT	denotes	the
T8632	34506-34514	NN	denotes	lowering
T8633	34515-34517	IN	denotes	of
T8634	34518-34524	NN	denotes	leptin
T8635	34525-34528	MD	denotes	may
T8636	34537-34540	DT	denotes	the
T8637	34547-34553	NNS	denotes	levels
T8638	34541-34546	JJR	denotes	lower
T8639	34554-34556	IN	denotes	of
T8640	34557-34560	NN	denotes	CTX
T8641	34561-34563	IN	denotes	in
T8642	34564-34567	DT	denotes	the
T8643	34568-34573	NN	denotes	serum
T8644	34574-34576	IN	denotes	of
T8645	34577-34582	NN	denotes	Sam68
T8646	34586-34590	NNS	denotes	mice
T8647	34582-34583	SYM	denotes	−
T8648	34583-34584	HYPH	denotes	/
T8649	34584-34585	SYM	denotes	−
T8650	34590-34591	.	denotes	.
T8651	34591-34895	sentence	denotes	These findings suggest that Sam68 may be regulating bone metabolism at two different levels: (1) the absence of Sam68 results in lower leptin levels that may reduce bone resorption via the sympathetic nervous system and (2) the absence of Sam68 favors osteoblast, rather than adipocyte, differentiation.
T8652	34592-34597	DT	denotes	These
T8653	34598-34606	NNS	denotes	findings
T8654	34607-34614	VBP	denotes	suggest
T8655	34710-34717	VBZ	denotes	results
T8656	34615-34619	IN	denotes	that
T8657	34633-34643	VBG	denotes	regulating
T8658	34620-34625	NN	denotes	Sam68
T8659	34626-34629	MD	denotes	may
T8660	34630-34632	VB	denotes	be
T8661	34644-34648	NN	denotes	bone
T8662	34649-34659	NN	denotes	metabolism
T8663	34660-34662	IN	denotes	at
T8664	34663-34666	CD	denotes	two
T8665	34677-34683	NNS	denotes	levels
T8666	34667-34676	JJ	denotes	different
T8667	34683-34685	:	denotes	:
T8668	34685-34686	-LRB-	denotes	(
T8669	34686-34687	LS	denotes	1
T8670	34687-34688	-RRB-	denotes	)
T8671	34689-34692	DT	denotes	the
T8672	34693-34700	NN	denotes	absence
T8673	34701-34703	IN	denotes	of
T8674	34704-34709	NN	denotes	Sam68
T8675	34718-34720	IN	denotes	in
T8676	34721-34726	JJR	denotes	lower
T8677	34734-34740	NNS	denotes	levels
T8678	34727-34733	NN	denotes	leptin
T8679	34741-34745	WDT	denotes	that
T8680	34750-34756	VB	denotes	reduce
T8681	34746-34749	MD	denotes	may
T8682	34757-34761	NN	denotes	bone
T8683	34762-34772	NN	denotes	resorption
T8684	34773-34776	IN	denotes	via
T8685	34777-34780	DT	denotes	the
T8686	34801-34807	NN	denotes	system
T8687	34781-34792	JJ	denotes	sympathetic
T8688	34793-34800	JJ	denotes	nervous
T8689	34808-34811	CC	denotes	and
T8690	34812-34813	-LRB-	denotes	(
T8691	34813-34814	LS	denotes	2
T8692	34837-34843	VBZ	denotes	favors
T8693	34814-34815	-RRB-	denotes	)
T8694	34816-34819	DT	denotes	the
T8695	34820-34827	NN	denotes	absence
T8696	34828-34830	IN	denotes	of
T8697	34831-34836	NN	denotes	Sam68
T8698	34844-34854	NN	denotes	osteoblast
T8699	34879-34894	NN	denotes	differentiation
T8700	34854-34856	,	denotes	,
T8701	34856-34862	RB	denotes	rather
T8702	34863-34867	IN	denotes	than
T8703	34868-34877	NN	denotes	adipocyte
T8704	34877-34879	,	denotes	,
T8705	34894-34895	.	denotes	.
T8706	34895-35029	sentence	denotes	In conclusion, our data define a physiologic role for Sam68 in bone metabolism and bone marrow mesenchymal stem cell differentiation.
T8707	34896-34898	IN	denotes	In
T8708	34920-34926	VBP	denotes	define
T8709	34899-34909	NN	denotes	conclusion
T8710	34909-34911	,	denotes	,
T8711	34911-34914	PRP$	denotes	our
T8712	34915-34919	NNS	denotes	data
T8713	34927-34928	DT	denotes	a
T8714	34941-34945	NN	denotes	role
T8715	34929-34940	JJ	denotes	physiologic
T8716	34946-34949	IN	denotes	for
T8717	34950-34955	NN	denotes	Sam68
T8718	34956-34958	IN	denotes	in
T8719	34959-34963	NN	denotes	bone
T8720	34964-34974	NN	denotes	metabolism
T8721	34975-34978	CC	denotes	and
T8722	34979-34983	NN	denotes	bone
T8723	34984-34990	NN	denotes	marrow
T8724	35013-35028	NN	denotes	differentiation
T8726	35008-35012	NN	denotes	cell
T8727	35003-35007	NN	denotes	stem
T8728	35028-35029	.	denotes	.
T8729	35029-35142	sentence	denotes	The bone phenotype observed in Sam68−/− mice imply that inhibitors of Sam68 could prevent age-related bone loss.
T8730	35030-35033	DT	denotes	The
T8731	35039-35048	NN	denotes	phenotype
T8732	35034-35038	NN	denotes	bone
T8733	35075-35080	VBP	denotes	imply
T8734	35049-35057	VBN	denotes	observed
T8735	35058-35060	IN	denotes	in
T8736	35061-35066	NN	denotes	Sam68
T8737	35070-35074	NNS	denotes	mice
T8738	35066-35067	SYM	denotes	−
T8739	35067-35068	HYPH	denotes	/
T8740	35068-35069	SYM	denotes	−
T8741	35081-35085	IN	denotes	that
T8742	35112-35119	VB	denotes	prevent
T8743	35086-35096	NNS	denotes	inhibitors
T8744	35097-35099	IN	denotes	of
T8745	35100-35105	NN	denotes	Sam68
T8746	35106-35111	MD	denotes	could
T8747	35120-35123	NN	denotes	age
T8748	35124-35131	VBN	denotes	related
T8749	35123-35124	HYPH	denotes	-
T8750	35137-35141	NN	denotes	loss
T8751	35132-35136	NN	denotes	bone
T8752	35141-35142	.	denotes	.
T8753	35142-35328	sentence	denotes	Furthermore, the results also suggest that Sam68 expression levels, hypomorphism, and mutations in humans may influence susceptibility to marrow adipocyte accumulation and osteoporosis.
T8754	35143-35154	RB	denotes	Furthermore
T8755	35173-35180	VBP	denotes	suggest
T8756	35154-35156	,	denotes	,
T8757	35156-35159	DT	denotes	the
T8758	35160-35167	NNS	denotes	results
T8759	35168-35172	RB	denotes	also
T8760	35181-35185	IN	denotes	that
T8761	35253-35262	VB	denotes	influence
T8762	35186-35191	NN	denotes	Sam68
T8763	35203-35209	NNS	denotes	levels
T8764	35192-35202	NN	denotes	expression
T8765	35209-35211	,	denotes	,
T8766	35211-35223	NN	denotes	hypomorphism
T8767	35223-35225	,	denotes	,
T8768	35225-35228	CC	denotes	and
T8769	35229-35238	NNS	denotes	mutations
T8770	35239-35241	IN	denotes	in
T8771	35242-35248	NNS	denotes	humans
T8772	35249-35252	MD	denotes	may
T8773	35263-35277	NN	denotes	susceptibility
T8774	35278-35280	IN	denotes	to
T8775	35281-35287	NN	denotes	marrow
T8776	35288-35297	NN	denotes	adipocyte
T8777	35298-35310	NN	denotes	accumulation
T8778	35311-35314	CC	denotes	and
T8779	35315-35327	NN	denotes	osteoporosis
T8780	35327-35328	.	denotes	.
T8781	35328-35400	sentence	denotes	Our findings also identify a new animal model to study aging bone loss.
T8782	35329-35332	PRP$	denotes	Our
T8783	35333-35341	NNS	denotes	findings
T8784	35347-35355	VBP	denotes	identify
T8785	35342-35346	RB	denotes	also
T8786	35356-35357	DT	denotes	a
T8787	35369-35374	NN	denotes	model
T8788	35358-35361	JJ	denotes	new
T8789	35362-35368	NN	denotes	animal
T8790	35375-35377	TO	denotes	to
T8791	35378-35383	VB	denotes	study
T8792	35384-35389	VBG	denotes	aging
T8793	35395-35399	NN	denotes	loss
T8794	35390-35394	NN	denotes	bone
T8795	35399-35400	.	denotes	.
T8863	35425-35435	JJ	denotes	Histologic
T8864	35480-35488	NNS	denotes	analyses
T8865	35435-35437	,	denotes	,
T8866	35437-35456	JJ	denotes	immunohistochemical
T8867	35456-35458	,	denotes	,
T8868	35458-35461	CC	denotes	and
T8869	35462-35479	JJ	denotes	histomorphometric
T8870	35488-35489	.	denotes	.
T8871	35489-35562	sentence	denotes	All analyses were performed essentially as described previously [62,63].
T8872	35490-35493	DT	denotes	All
T8873	35494-35502	NNS	denotes	analyses
T8874	35508-35517	VBN	denotes	performed
T8875	35503-35507	VBD	denotes	were
T8876	35518-35529	RB	denotes	essentially
T8877	35533-35542	VBN	denotes	described
T8878	35530-35532	IN	denotes	as
T8879	35543-35553	RB	denotes	previously
T8880	35554-35555	-LRB-	denotes	[
T8881	35558-35560	CD	denotes	63
T8882	35555-35557	CD	denotes	62
T8883	35557-35558	,	denotes	,
T8884	35560-35561	-RRB-	denotes	]
T8885	35561-35562	.	denotes	.
T8886	35562-35757	sentence	denotes	Briefly, embryonic mice were removed from timed pregnant dams at E14.5 and E16.5 and fixed intact for 36 h in 4% paraformaldehyde, rinsed thoroughly in PBS, and processed for paraffin embedding.
T8887	35563-35570	RB	denotes	Briefly
T8888	35592-35599	VBN	denotes	removed
T8889	35570-35572	,	denotes	,
T8890	35572-35581	JJ	denotes	embryonic
T8891	35582-35586	NNS	denotes	mice
T8892	35587-35591	VBD	denotes	were
T8893	35600-35604	IN	denotes	from
T8894	35605-35610	VBN	denotes	timed
T8895	35620-35624	NNS	denotes	dams
T8896	35611-35619	JJ	denotes	pregnant
T8897	35625-35627	IN	denotes	at
T8898	35628-35633	NN	denotes	E14.5
T8899	35634-35637	CC	denotes	and
T8900	35638-35643	NN	denotes	E16.5
T8901	35644-35647	CC	denotes	and
T8902	35648-35653	VBN	denotes	fixed
T8903	35654-35660	JJ	denotes	intact
T8904	35661-35664	IN	denotes	for
T8905	35665-35667	CD	denotes	36
T8906	35668-35669	NN	denotes	h
T8907	35670-35672	IN	denotes	in
T8908	35673-35674	CD	denotes	4
T8909	35674-35675	NN	denotes	%
T8910	35676-35692	NN	denotes	paraformaldehyde
T8911	35692-35694	,	denotes	,
T8912	35694-35700	VBN	denotes	rinsed
T8913	35701-35711	RB	denotes	thoroughly
T8914	35712-35714	IN	denotes	in
T8915	35715-35718	NN	denotes	PBS
T8916	35718-35720	,	denotes	,
T8917	35720-35723	CC	denotes	and
T8918	35724-35733	VBN	denotes	processed
T8919	35734-35737	IN	denotes	for
T8920	35738-35746	NN	denotes	paraffin
T8921	35747-35756	NN	denotes	embedding
T8922	35756-35757	.	denotes	.
T8923	35757-36012	sentence	denotes	Serial 4-μm sections were cut on a modified Leica RM 2155 rotary microtome (Leica Microsystems, Richmond Hill, Ontario, Canada), stained with a 1:600 dilution of the AD1 anti-Sam68 antibody [46] and counterstained with either methyl green or hematoxylin.
T8924	35758-35764	JJ	denotes	Serial
T8925	35770-35778	NNS	denotes	sections
T8926	35765-35766	CD	denotes	4
T8927	35767-35769	NN	denotes	μm
T8928	35766-35767	HYPH	denotes	-
T8929	35784-35787	VBN	denotes	cut
T8930	35779-35783	VBD	denotes	were
T8931	35788-35790	IN	denotes	on
T8932	35791-35792	DT	denotes	a
T8933	35823-35832	NN	denotes	microtome
T8934	35793-35801	VBN	denotes	modified
T8935	35802-35807	NNP	denotes	Leica
T8936	35808-35810	NNP	denotes	RM
T8937	35811-35815	CD	denotes	2155
T8938	35816-35822	JJ	denotes	rotary
T8939	35833-35834	-LRB-	denotes	(
T8940	35840-35852	NNP	denotes	Microsystems
T8941	35834-35839	NNP	denotes	Leica
T8942	35852-35854	,	denotes	,
T8943	35854-35862	NNP	denotes	Richmond
T8944	35863-35867	NNP	denotes	Hill
T8945	35867-35869	,	denotes	,
T8946	35869-35876	NNP	denotes	Ontario
T8947	35876-35878	,	denotes	,
T8948	35878-35884	NNP	denotes	Canada
T8949	35884-35885	-RRB-	denotes	)
T8950	35885-35887	,	denotes	,
T8951	35887-35894	VBN	denotes	stained
T8952	35895-35899	IN	denotes	with
T8953	35900-35901	DT	denotes	a
T8954	35908-35916	NN	denotes	dilution
T8955	35902-35903	CD	denotes	1
T8956	35903-35904	SYM	denotes	:
T8957	35904-35907	CD	denotes	600
T8958	35917-35919	IN	denotes	of
T8959	35920-35923	DT	denotes	the
T8960	35939-35947	NN	denotes	antibody
T8961	35924-35927	NN	denotes	AD1
T8962	35928-35938	JJ	denotes	anti-Sam68
T8963	35948-35949	-LRB-	denotes	[
T8964	35949-35951	CD	denotes	46
T8965	35951-35952	-RRB-	denotes	]
T8966	35953-35956	CC	denotes	and
T8967	35957-35971	VBN	denotes	counterstained
T8968	35972-35976	IN	denotes	with
T8969	35977-35983	CC	denotes	either
T8970	35991-35996	NN	denotes	green
T8971	35984-35990	NN	denotes	methyl
T8972	35997-35999	CC	denotes	or
T8973	36000-36011	NN	denotes	hematoxylin
T8974	36011-36012	.	denotes	.
T8975	36012-36189	sentence	denotes	Adult mice were given an intraperitoneal injection of 30 mg/kg calcein at 7 days and 30 mg/kg tetracycline at 2 days prior to sacrifice to label actively mineralizing surfaces.
T8976	36013-36018	JJ	denotes	Adult
T8977	36019-36023	NNS	denotes	mice
T8978	36029-36034	VBN	denotes	given
T8979	36024-36028	VBD	denotes	were
T8980	36035-36037	DT	denotes	an
T8981	36054-36063	NN	denotes	injection
T8982	36038-36053	JJ	denotes	intraperitoneal
T8983	36064-36066	IN	denotes	of
T8984	36067-36069	CD	denotes	30
T8985	36070-36072	NN	denotes	mg
T8986	36076-36083	NN	denotes	calcein
T8987	36072-36073	SYM	denotes	/
T8988	36073-36075	NN	denotes	kg
T8989	36084-36086	IN	denotes	at
T8990	36087-36088	CD	denotes	7
T8991	36089-36093	NNS	denotes	days
T8992	36094-36097	CC	denotes	and
T8993	36098-36100	CD	denotes	30
T8994	36101-36103	NN	denotes	mg
T8995	36107-36119	NN	denotes	tetracycline
T8996	36103-36104	SYM	denotes	/
T8997	36104-36106	NN	denotes	kg
T8998	36120-36122	IN	denotes	at
T8999	36123-36124	CD	denotes	2
T9000	36125-36129	NNS	denotes	days
T9001	36130-36135	JJ	denotes	prior
T9002	36136-36138	IN	denotes	to
T9003	36139-36148	NN	denotes	sacrifice
T9004	36149-36151	TO	denotes	to
T9005	36152-36157	VB	denotes	label
T9006	36158-36166	RB	denotes	actively
T9007	36167-36179	VBG	denotes	mineralizing
T9008	36180-36188	NNS	denotes	surfaces
T9009	36188-36189	.	denotes	.
T9010	36189-36386	sentence	denotes	After overnight fixation in 4% paraformaldehyde and rinsing in PBS, the left femur and tibia were embedded in polymethylmethacrylate (MMA) or a mixture of 50% MMA and 50% glycolmethacrylate (GMA).
T9011	36190-36195	IN	denotes	After
T9012	36288-36296	VBN	denotes	embedded
T9013	36196-36205	RB	denotes	overnight
T9014	36206-36214	NN	denotes	fixation
T9015	36215-36217	IN	denotes	in
T9016	36218-36219	CD	denotes	4
T9017	36219-36220	NN	denotes	%
T9018	36221-36237	NN	denotes	paraformaldehyde
T9019	36238-36241	CC	denotes	and
T9020	36242-36249	VBG	denotes	rinsing
T9021	36250-36252	IN	denotes	in
T9022	36253-36256	NN	denotes	PBS
T9023	36256-36258	,	denotes	,
T9024	36258-36261	DT	denotes	the
T9025	36267-36272	NN	denotes	femur
T9026	36262-36266	JJ	denotes	left
T9027	36273-36276	CC	denotes	and
T9028	36277-36282	NN	denotes	tibia
T9029	36283-36287	VBD	denotes	were
T9030	36297-36299	IN	denotes	in
T9031	36300-36322	NN	denotes	polymethylmethacrylate
T9032	36323-36324	-LRB-	denotes	(
T9033	36324-36327	NN	denotes	MMA
T9034	36327-36328	-RRB-	denotes	)
T9035	36329-36331	CC	denotes	or
T9036	36332-36333	DT	denotes	a
T9037	36334-36341	NN	denotes	mixture
T9038	36342-36344	IN	denotes	of
T9039	36345-36347	CD	denotes	50
T9040	36347-36348	NN	denotes	%
T9041	36349-36352	NN	denotes	MMA
T9042	36353-36356	CC	denotes	and
T9043	36357-36359	CD	denotes	50
T9044	36359-36360	NN	denotes	%
T9045	36361-36379	NN	denotes	glycolmethacrylate
T9046	36380-36381	-LRB-	denotes	(
T9047	36381-36384	NN	denotes	GMA
T9048	36384-36385	-RRB-	denotes	)
T9049	36385-36386	.	denotes	.
T9050	36386-36600	sentence	denotes	Serial 4- to 6-μm sections of MMA-embedded tissues were left unstained or stained with von Kossa and toluidine blue or with toluidine blue alone, while 4-μm MMA-GMA sections were stained for TRAP and ALP activity.
T9051	36387-36393	JJ	denotes	Serial
T9052	36405-36413	NNS	denotes	sections
T9053	36394-36395	CD	denotes	4
T9054	36400-36401	CD	denotes	6
T9055	36395-36396	HYPH	denotes	-
T9056	36397-36399	IN	denotes	to
T9057	36402-36404	NN	denotes	μm
T9058	36401-36402	HYPH	denotes	-
T9059	36443-36447	VBN	denotes	left
T9060	36414-36416	IN	denotes	of
T9061	36417-36420	NN	denotes	MMA
T9062	36421-36429	VBN	denotes	embedded
T9063	36420-36421	HYPH	denotes	-
T9064	36430-36437	NNS	denotes	tissues
T9065	36438-36442	VBD	denotes	were
T9066	36448-36457	JJ	denotes	unstained
T9067	36458-36460	CC	denotes	or
T9068	36461-36468	VBN	denotes	stained
T9069	36469-36473	IN	denotes	with
T9070	36474-36477	NNP	denotes	von
T9071	36478-36483	NNP	denotes	Kossa
T9072	36484-36487	CC	denotes	and
T9073	36488-36497	NN	denotes	toluidine
T9074	36498-36502	NN	denotes	blue
T9075	36503-36505	CC	denotes	or
T9076	36506-36510	IN	denotes	with
T9077	36511-36520	NN	denotes	toluidine
T9078	36521-36525	NN	denotes	blue
T9079	36526-36531	RB	denotes	alone
T9080	36531-36533	,	denotes	,
T9081	36533-36538	IN	denotes	while
T9082	36566-36573	VBN	denotes	stained
T9083	36539-36540	CD	denotes	4
T9084	36541-36543	NN	denotes	μm
T9085	36540-36541	HYPH	denotes	-
T9086	36552-36560	NNS	denotes	sections
T9087	36544-36547	NN	denotes	MMA
T9088	36548-36551	NN	denotes	GMA
T9089	36547-36548	HYPH	denotes	-
T9090	36561-36565	VBD	denotes	were
T9091	36574-36577	IN	denotes	for
T9092	36578-36582	NN	denotes	TRAP
T9093	36591-36599	NN	denotes	activity
T9094	36583-36586	CC	denotes	and
T9095	36587-36590	NN	denotes	ALP
T9096	36599-36600	.	denotes	.
T9097	36600-36919	sentence	denotes	Images were captured using a Leica DMR microscope (Leica Microsystems) equipped with a Retiga 1300 camera (Qimaging, Burnaby, British Columbia, Canada) and the primary histomorphometric data obtained using Bioquant Nova Prime image analysis software (Bioquant Image Analysis Corp, Nashville, Tennessee, United States).
T9098	36601-36607	NNS	denotes	Images
T9099	36613-36621	VBN	denotes	captured
T9100	36608-36612	VBD	denotes	were
T9101	36622-36627	VBG	denotes	using
T9102	36628-36629	DT	denotes	a
T9103	36640-36650	NN	denotes	microscope
T9104	36630-36635	NNP	denotes	Leica
T9105	36636-36639	NN	denotes	DMR
T9106	36651-36652	-LRB-	denotes	(
T9107	36658-36670	NNP	denotes	Microsystems
T9108	36652-36657	NNP	denotes	Leica
T9109	36670-36671	-RRB-	denotes	)
T9110	36672-36680	VBN	denotes	equipped
T9111	36681-36685	IN	denotes	with
T9112	36686-36687	DT	denotes	a
T9113	36700-36706	NN	denotes	camera
T9114	36688-36694	NNP	denotes	Retiga
T9115	36695-36699	CD	denotes	1300
T9116	36707-36708	-LRB-	denotes	(
T9117	36708-36716	NNP	denotes	Qimaging
T9118	36716-36718	,	denotes	,
T9119	36718-36725	NNP	denotes	Burnaby
T9120	36725-36727	,	denotes	,
T9121	36727-36734	NNP	denotes	British
T9122	36735-36743	NNP	denotes	Columbia
T9123	36743-36745	,	denotes	,
T9124	36745-36751	NNP	denotes	Canada
T9125	36751-36752	-RRB-	denotes	)
T9126	36753-36756	CC	denotes	and
T9127	36757-36760	DT	denotes	the
T9128	36787-36791	NNS	denotes	data
T9129	36761-36768	JJ	denotes	primary
T9130	36769-36786	JJ	denotes	histomorphometric
T9131	36792-36800	VBN	denotes	obtained
T9132	36801-36806	VBG	denotes	using
T9133	36807-36815	NNP	denotes	Bioquant
T9134	36821-36826	NNP	denotes	Prime
T9135	36816-36820	NNP	denotes	Nova
T9136	36842-36850	NN	denotes	software
T9137	36827-36832	NN	denotes	image
T9138	36833-36841	NN	denotes	analysis
T9139	36851-36852	-LRB-	denotes	(
T9140	36876-36880	NNP	denotes	Corp
T9141	36852-36860	NNP	denotes	Bioquant
T9142	36861-36866	NNP	denotes	Image
T9143	36867-36875	NNP	denotes	Analysis
T9144	36880-36882	,	denotes	,
T9145	36882-36891	NNP	denotes	Nashville
T9146	36891-36893	,	denotes	,
T9147	36893-36902	NNP	denotes	Tennessee
T9148	36902-36904	,	denotes	,
T9149	36904-36910	NNP	denotes	United
T9150	36911-36917	NNP	denotes	States
T9151	36917-36918	-RRB-	denotes	)
T9152	36918-36919	.	denotes	.
T9153	36919-37039	sentence	denotes	Nomenclature and abbreviations conform to those recommended by the American Society for Bone and Mineral Research [50].
T9154	36920-36932	NN	denotes	Nomenclature
T9155	36951-36958	VBP	denotes	conform
T9156	36933-36936	CC	denotes	and
T9157	36937-36950	NNS	denotes	abbreviations
T9158	36959-36961	IN	denotes	to
T9159	36962-36967	DT	denotes	those
T9160	36968-36979	VBN	denotes	recommended
T9161	36980-36982	IN	denotes	by
T9162	36983-36986	DT	denotes	the
T9163	36996-37003	NNP	denotes	Society
T9164	36987-36995	NNP	denotes	American
T9165	37004-37007	IN	denotes	for
T9166	37008-37012	NNP	denotes	Bone
T9167	37025-37033	NNP	denotes	Research
T9168	37013-37016	CC	denotes	and
T9169	37017-37024	NNP	denotes	Mineral
T9170	37034-37035	-LRB-	denotes	[
T9171	37035-37037	CD	denotes	50
T9172	37037-37038	-RRB-	denotes	]
T9173	37038-37039	.	denotes	.
T9293	37041-37051	NN	denotes	Generation
T9294	37052-37054	IN	denotes	of
T9295	37055-37059	NNS	denotes	mice
T9296	37060-37064	IN	denotes	with
T9297	37065-37073	VBN	denotes	targeted
T9298	37074-37084	NN	denotes	disruption
T9299	37085-37087	IN	denotes	of
T9300	37088-37091	DT	denotes	the
T9301	37098-37102	NN	denotes	gene
T9302	37092-37097	NN	denotes	sam68
T9303	37102-37103	.	denotes	.
T9304	37103-37244	sentence	denotes	A λ bacteriophage clone encompassing Sam68 exons 3 to 9 was isolated from a 129/SvJ genomic library using full-length Sam68 cDNA as a probe.
T9305	37104-37105	DT	denotes	A
T9306	37122-37127	NN	denotes	clone
T9307	37106-37107	NN	denotes	λ
T9308	37108-37121	NN	denotes	bacteriophage
T9309	37164-37172	VBN	denotes	isolated
T9310	37128-37140	VBG	denotes	encompassing
T9311	37141-37146	NN	denotes	Sam68
T9312	37153-37154	CD	denotes	3
T9313	37147-37152	NNS	denotes	exons
T9314	37155-37157	IN	denotes	to
T9315	37158-37159	CD	denotes	9
T9316	37160-37163	VBD	denotes	was
T9317	37173-37177	IN	denotes	from
T9318	37178-37179	DT	denotes	a
T9319	37196-37203	NN	denotes	library
T9320	37180-37183	CD	denotes	129
T9321	37184-37187	NN	denotes	SvJ
T9322	37183-37184	HYPH	denotes	/
T9323	37188-37195	JJ	denotes	genomic
T9324	37204-37209	VBG	denotes	using
T9325	37210-37214	JJ	denotes	full
T9326	37215-37221	NN	denotes	length
T9327	37214-37215	HYPH	denotes	-
T9328	37228-37232	NN	denotes	cDNA
T9329	37222-37227	NN	denotes	Sam68
T9330	37233-37235	IN	denotes	as
T9331	37236-37237	DT	denotes	a
T9332	37238-37243	NN	denotes	probe
T9333	37243-37244	.	denotes	.
T9334	37244-37454	sentence	denotes	XbaI-digested Sam68 genomic DNA fragments of 4 kb (encompassing exon 4 and part of exon 5) and 3kb (spanning part of exon 5 and exon 6) were subcloned in Bluescript SK resulting in pBS4 and pBS3, respectively.
T9335	37245-37249	NN	denotes	XbaI
T9336	37250-37258	VBN	denotes	digested
T9337	37249-37250	HYPH	denotes	-
T9338	37277-37286	NNS	denotes	fragments
T9339	37259-37264	NN	denotes	Sam68
T9340	37265-37272	JJ	denotes	genomic
T9341	37273-37276	NN	denotes	DNA
T9342	37386-37395	VBN	denotes	subcloned
T9343	37287-37289	IN	denotes	of
T9344	37290-37291	CD	denotes	4
T9345	37292-37294	NN	denotes	kb
T9346	37295-37296	-LRB-	denotes	(
T9347	37296-37308	VBG	denotes	encompassing
T9348	37309-37313	NN	denotes	exon
T9349	37314-37315	CD	denotes	4
T9350	37316-37319	CC	denotes	and
T9351	37320-37324	NN	denotes	part
T9352	37325-37327	IN	denotes	of
T9353	37328-37332	NN	denotes	exon
T9354	37333-37334	CD	denotes	5
T9355	37334-37335	-RRB-	denotes	)
T9356	37336-37339	CC	denotes	and
T9357	37340-37343	NN	denotes	3kb
T9358	37344-37345	-LRB-	denotes	(
T9359	37345-37353	VBG	denotes	spanning
T9360	37354-37358	NN	denotes	part
T9361	37359-37361	IN	denotes	of
T9362	37362-37366	NN	denotes	exon
T9363	37367-37368	CD	denotes	5
T9364	37369-37372	CC	denotes	and
T9365	37373-37377	NN	denotes	exon
T9366	37378-37379	CD	denotes	6
T9367	37379-37380	-RRB-	denotes	)
T9368	37381-37385	VBD	denotes	were
T9369	37396-37398	IN	denotes	in
T9370	37399-37409	NN	denotes	Bluescript
T9371	37410-37412	NN	denotes	SK
T9372	37413-37422	VBG	denotes	resulting
T9373	37423-37425	IN	denotes	in
T9374	37426-37430	NN	denotes	pBS4
T9375	37431-37434	CC	denotes	and
T9376	37435-37439	NN	denotes	pBS3
T9377	37439-37441	,	denotes	,
T9378	37441-37453	RB	denotes	respectively
T9379	37453-37454	.	denotes	.
T9380	37454-37601	sentence	denotes	A DNA fragment was amplified from pBS4 with the following oligonucleotides (5′-AAT GTC TAG AAA CAA CTC ATA TAC AGA C-3′) and the universal primer.
T9381	37455-37456	DT	denotes	A
T9382	37461-37469	NN	denotes	fragment
T9383	37457-37460	NN	denotes	DNA
T9384	37474-37483	VBN	denotes	amplified
T9385	37470-37473	VBD	denotes	was
T9386	37484-37488	IN	denotes	from
T9387	37489-37493	NN	denotes	pBS4
T9388	37494-37498	IN	denotes	with
T9389	37499-37502	DT	denotes	the
T9390	37513-37529	NNS	denotes	oligonucleotides
T9391	37503-37512	JJ	denotes	following
T9392	37530-37531	-LRB-	denotes	(
T9393	37531-37532	CD	denotes	5
T9394	37532-37533	SYM	denotes	′
T9395	37533-37534	HYPH	denotes	-
T9396	37534-37537	NN	denotes	AAT
T9397	37570-37571	NN	denotes	C
T9398	37538-37541	NN	denotes	GTC
T9399	37542-37545	NN	denotes	TAG
T9400	37546-37549	NN	denotes	AAA
T9401	37550-37553	NN	denotes	CAA
T9402	37554-37557	NN	denotes	CTC
T9403	37558-37561	NN	denotes	ATA
T9404	37562-37565	NN	denotes	TAC
T9405	37566-37569	NN	denotes	AGA
T9406	37571-37572	HYPH	denotes	-
T9407	37572-37573	CD	denotes	3
T9408	37573-37574	SYM	denotes	′
T9409	37574-37575	-RRB-	denotes	)
T9410	37576-37579	CC	denotes	and
T9411	37580-37583	DT	denotes	the
T9412	37594-37600	NN	denotes	primer
T9413	37584-37593	JJ	denotes	universal
T9414	37600-37601	.	denotes	.
T9415	37601-37752	sentence	denotes	The XbaI-digested 1-kb DNA fragment was subcloned in the XbaI site of pPNT (a gift from Andrew Karaplis, McGill University, Montréal, Quebec, Canada).
T9416	37602-37605	DT	denotes	The
T9417	37629-37637	NN	denotes	fragment
T9418	37606-37610	NN	denotes	XbaI
T9419	37611-37619	VBN	denotes	digested
T9420	37610-37611	HYPH	denotes	-
T9421	37620-37621	CD	denotes	1
T9422	37622-37624	NN	denotes	kb
T9423	37621-37622	HYPH	denotes	-
T9424	37625-37628	NN	denotes	DNA
T9425	37642-37651	VBN	denotes	subcloned
T9426	37638-37641	VBD	denotes	was
T9427	37652-37654	IN	denotes	in
T9428	37655-37658	DT	denotes	the
T9429	37664-37668	NN	denotes	site
T9430	37659-37663	NN	denotes	XbaI
T9431	37669-37671	IN	denotes	of
T9432	37672-37676	NN	denotes	pPNT
T9433	37677-37678	-LRB-	denotes	(
T9434	37680-37684	NN	denotes	gift
T9435	37678-37679	DT	denotes	a
T9436	37685-37689	IN	denotes	from
T9437	37690-37696	NNP	denotes	Andrew
T9438	37697-37705	NNP	denotes	Karaplis
T9439	37705-37707	,	denotes	,
T9440	37707-37713	NNP	denotes	McGill
T9441	37714-37724	NNP	denotes	University
T9442	37724-37726	,	denotes	,
T9443	37726-37734	NNP	denotes	Montréal
T9444	37734-37736	,	denotes	,
T9445	37736-37742	NNP	denotes	Quebec
T9446	37742-37744	,	denotes	,
T9447	37744-37750	NNP	denotes	Canada
T9448	37750-37751	-RRB-	denotes	)
T9449	37751-37752	.	denotes	.
T9450	37752-37966	sentence	denotes	The 3-kb fragment from pBS3 was amplified by PCR with (5′-GGG ATG CGG CCG CTC TAG AAT TGT CCT ACT TGA ACG G-3') and (5′-CGG TGG CGG CCG CTG TCG ACC TGA GTA ACA TTT CTT A-3′) and subcloned in the NotI site of pPNT.
T9451	37753-37756	DT	denotes	The
T9452	37762-37770	NN	denotes	fragment
T9453	37757-37758	CD	denotes	3
T9454	37759-37761	NN	denotes	kb
T9455	37758-37759	HYPH	denotes	-
T9456	37785-37794	VBN	denotes	amplified
T9457	37771-37775	IN	denotes	from
T9458	37776-37780	NN	denotes	pBS3
T9459	37781-37784	VBD	denotes	was
T9460	37795-37797	IN	denotes	by
T9461	37798-37801	NN	denotes	PCR
T9462	37802-37806	IN	denotes	with
T9463	37807-37808	-LRB-	denotes	(
T9464	37808-37809	CD	denotes	5
T9465	37809-37810	SYM	denotes	′
T9466	37810-37811	HYPH	denotes	-
T9467	37811-37814	NN	denotes	GGG
T9468	37859-37860	NN	denotes	G
T9469	37815-37818	NN	denotes	ATG
T9470	37819-37822	NN	denotes	CGG
T9471	37823-37826	NN	denotes	CCG
T9472	37827-37830	NN	denotes	CTC
T9473	37831-37834	NN	denotes	TAG
T9474	37835-37838	NN	denotes	AAT
T9475	37839-37842	NN	denotes	TGT
T9476	37843-37846	NN	denotes	CCT
T9477	37847-37850	NN	denotes	ACT
T9478	37851-37854	NN	denotes	TGA
T9479	37855-37858	NN	denotes	ACG
T9480	37860-37861	HYPH	denotes	-
T9481	37861-37862	CD	denotes	3
T9482	37862-37863	SYM	denotes	'
T9483	37863-37864	-RRB-	denotes	)
T9484	37865-37868	CC	denotes	and
T9485	37869-37870	-LRB-	denotes	(
T9486	37870-37871	CD	denotes	5
T9487	37871-37872	SYM	denotes	′
T9488	37872-37873	HYPH	denotes	-
T9489	37873-37876	NN	denotes	CGG
T9490	37921-37922	NN	denotes	A
T9491	37877-37880	NN	denotes	TGG
T9492	37881-37884	NN	denotes	CGG
T9493	37885-37888	NN	denotes	CCG
T9494	37889-37892	NN	denotes	CTG
T9495	37893-37896	NN	denotes	TCG
T9496	37897-37900	NN	denotes	ACC
T9497	37901-37904	NN	denotes	TGA
T9498	37905-37908	NN	denotes	GTA
T9499	37909-37912	NN	denotes	ACA
T9500	37913-37916	NN	denotes	TTT
T9501	37917-37920	NN	denotes	CTT
T9502	37922-37923	HYPH	denotes	-
T9503	37923-37924	CD	denotes	3
T9504	37924-37925	SYM	denotes	′
T9505	37925-37926	-RRB-	denotes	)
T9506	37927-37930	CC	denotes	and
T9507	37931-37940	VBN	denotes	subcloned
T9508	37941-37943	IN	denotes	in
T9509	37944-37947	DT	denotes	the
T9510	37953-37957	NN	denotes	site
T9511	37948-37952	NN	denotes	NotI
T9512	37958-37960	IN	denotes	of
T9513	37961-37965	NN	denotes	pPNT
T9514	37965-37966	.	denotes	.
T9515	37966-38074	sentence	denotes	The targeting vector pPNT-Sam68 replaces exon 4 and part of exon 5 with a neomycin-resistant gene cassette.
T9516	37967-37970	DT	denotes	The
T9517	37981-37987	NN	denotes	vector
T9518	37971-37980	NN	denotes	targeting
T9519	37999-38007	VBZ	denotes	replaces
T9520	37988-37992	NN	denotes	pPNT
T9521	37993-37998	NN	denotes	Sam68
T9522	37992-37993	HYPH	denotes	-
T9523	38008-38012	NN	denotes	exon
T9524	38013-38014	CD	denotes	4
T9525	38015-38018	CC	denotes	and
T9526	38019-38023	NN	denotes	part
T9527	38024-38026	IN	denotes	of
T9528	38027-38031	NN	denotes	exon
T9529	38032-38033	CD	denotes	5
T9530	38034-38038	IN	denotes	with
T9531	38039-38040	DT	denotes	a
T9532	38065-38073	NN	denotes	cassette
T9533	38041-38049	NN	denotes	neomycin
T9534	38050-38059	JJ	denotes	resistant
T9535	38049-38050	HYPH	denotes	-
T9536	38060-38064	NN	denotes	gene
T9537	38073-38074	.	denotes	.
T9538	38074-38231	sentence	denotes	An SalI site was introduced at the 3′ end of the 3-kb DNA fragment and was used to linearize the plasmid for electroporation into embryonic stem (ES) cells.
T9539	38075-38077	DT	denotes	An
T9540	38083-38087	NN	denotes	site
T9541	38078-38082	NN	denotes	SalI
T9542	38092-38102	VBN	denotes	introduced
T9543	38088-38091	VBD	denotes	was
T9544	38103-38105	IN	denotes	at
T9545	38106-38109	DT	denotes	the
T9546	38113-38116	NN	denotes	end
T9547	38110-38111	CD	denotes	3
T9548	38111-38112	SYM	denotes	′
T9549	38117-38119	IN	denotes	of
T9550	38120-38123	DT	denotes	the
T9551	38133-38141	NN	denotes	fragment
T9552	38124-38125	CD	denotes	3
T9553	38126-38128	NN	denotes	kb
T9554	38125-38126	HYPH	denotes	-
T9555	38129-38132	NN	denotes	DNA
T9556	38142-38145	CC	denotes	and
T9557	38146-38149	VBD	denotes	was
T9558	38150-38154	VBN	denotes	used
T9559	38155-38157	TO	denotes	to
T9560	38158-38167	VB	denotes	linearize
T9561	38168-38171	DT	denotes	the
T9562	38172-38179	NN	denotes	plasmid
T9563	38180-38183	IN	denotes	for
T9564	38184-38199	NN	denotes	electroporation
T9565	38200-38204	IN	denotes	into
T9566	38205-38214	JJ	denotes	embryonic
T9567	38215-38219	NN	denotes	stem
T9568	38225-38230	NNS	denotes	cells
T9569	38220-38221	-LRB-	denotes	(
T9570	38221-38223	NN	denotes	ES
T9571	38223-38224	-RRB-	denotes	)
T9572	38230-38231	.	denotes	.
T9573	38231-38384	sentence	denotes	Approximately 1,000 ES colonies were screened and two clones were identified that contained the Sam68 mutant allele, as determined by Southern blotting.
T9574	38232-38245	RB	denotes	Approximately
T9575	38246-38251	CD	denotes	1,000
T9576	38255-38263	NNS	denotes	colonies
T9577	38252-38254	NN	denotes	ES
T9578	38269-38277	VBN	denotes	screened
T9579	38264-38268	VBD	denotes	were
T9580	38278-38281	CC	denotes	and
T9581	38282-38285	CD	denotes	two
T9582	38286-38292	NNS	denotes	clones
T9583	38298-38308	VBN	denotes	identified
T9584	38293-38297	VBD	denotes	were
T9585	38309-38313	WDT	denotes	that
T9586	38314-38323	VBD	denotes	contained
T9587	38324-38327	DT	denotes	the
T9588	38328-38333	NN	denotes	Sam68
T9589	38341-38347	NN	denotes	allele
T9590	38334-38340	NN	denotes	mutant
T9591	38347-38349	,	denotes	,
T9592	38349-38351	IN	denotes	as
T9593	38352-38362	VBN	denotes	determined
T9594	38363-38365	IN	denotes	by
T9595	38366-38374	NNP	denotes	Southern
T9596	38375-38383	NN	denotes	blotting
T9597	38383-38384	.	denotes	.
T9598	38384-38577	sentence	denotes	Targeted ES cells were injected into 3.5-day-old BALB/c blastocysts and were transferred into CD-1 foster mothers, and animals classified as chimeras by coat color were mated with BALB/c mice.
T9599	38385-38393	VBN	denotes	Targeted
T9600	38397-38402	NNS	denotes	cells
T9601	38394-38396	NN	denotes	ES
T9602	38408-38416	VBN	denotes	injected
T9603	38403-38407	VBD	denotes	were
T9604	38417-38421	IN	denotes	into
T9605	38422-38425	CD	denotes	3.5
T9606	38426-38429	NN	denotes	day
T9607	38425-38426	HYPH	denotes	-
T9608	38430-38433	JJ	denotes	old
T9609	38429-38430	HYPH	denotes	-
T9610	38441-38452	NNS	denotes	blastocysts
T9611	38434-38438	NN	denotes	BALB
T9612	38439-38440	NN	denotes	c
T9613	38438-38439	HYPH	denotes	/
T9614	38453-38456	CC	denotes	and
T9615	38457-38461	VBD	denotes	were
T9616	38462-38473	VBN	denotes	transferred
T9617	38474-38478	IN	denotes	into
T9618	38479-38481	NN	denotes	CD
T9619	38491-38498	NNS	denotes	mothers
T9620	38481-38482	HYPH	denotes	-
T9621	38482-38483	CD	denotes	1
T9622	38484-38490	NN	denotes	foster
T9623	38498-38500	,	denotes	,
T9624	38500-38503	CC	denotes	and
T9625	38504-38511	NNS	denotes	animals
T9626	38554-38559	VBN	denotes	mated
T9627	38512-38522	VBN	denotes	classified
T9628	38523-38525	IN	denotes	as
T9629	38526-38534	NNS	denotes	chimeras
T9630	38535-38537	IN	denotes	by
T9631	38538-38542	NN	denotes	coat
T9632	38543-38548	NN	denotes	color
T9633	38549-38553	VBD	denotes	were
T9634	38560-38564	IN	denotes	with
T9635	38565-38569	NN	denotes	BALB
T9636	38570-38571	NN	denotes	c
T9637	38569-38570	HYPH	denotes	/
T9638	38572-38576	NNS	denotes	mice
T9639	38576-38577	.	denotes	.
T9640	38577-38665	sentence	denotes	Germ line transmission was achieved and the mice were maintained in C57BL/6 background.
T9641	38578-38582	NN	denotes	Germ
T9642	38583-38587	NN	denotes	line
T9643	38588-38600	NN	denotes	transmission
T9644	38605-38613	VBN	denotes	achieved
T9645	38601-38604	VBD	denotes	was
T9646	38614-38617	CC	denotes	and
T9647	38618-38621	DT	denotes	the
T9648	38622-38626	NNS	denotes	mice
T9649	38632-38642	VBN	denotes	maintained
T9650	38627-38631	VBD	denotes	were
T9651	38643-38645	IN	denotes	in
T9652	38646-38651	NN	denotes	C57BL
T9653	38654-38664	NN	denotes	background
T9654	38651-38652	HYPH	denotes	/
T9655	38652-38653	CD	denotes	6
T9656	38664-38665	.	denotes	.
T9657	38665-38871	sentence	denotes	The mice used for this study represent mice that were backcrossed in C57BL/6 between three and eight generations; in addition, we maintained the mice in the 129/SvJ strain and observed a similar phenotype.
T9658	38666-38669	DT	denotes	The
T9659	38670-38674	NNS	denotes	mice
T9660	38695-38704	VBP	denotes	represent
T9661	38675-38679	VBN	denotes	used
T9662	38680-38683	IN	denotes	for
T9663	38684-38688	DT	denotes	this
T9664	38689-38694	NN	denotes	study
T9665	38796-38806	VBD	denotes	maintained
T9666	38705-38709	NNS	denotes	mice
T9667	38710-38714	WDT	denotes	that
T9668	38720-38731	VBN	denotes	backcrossed
T9669	38715-38719	VBD	denotes	were
T9670	38732-38734	IN	denotes	in
T9671	38735-38740	NN	denotes	C57BL
T9672	38740-38741	HYPH	denotes	/
T9673	38741-38742	CD	denotes	6
T9674	38743-38750	IN	denotes	between
T9675	38751-38756	CD	denotes	three
T9676	38767-38778	NNS	denotes	generations
T9677	38757-38760	CC	denotes	and
T9678	38761-38766	CD	denotes	eight
T9679	38778-38779	:	denotes	;
T9680	38780-38782	IN	denotes	in
T9681	38783-38791	NN	denotes	addition
T9682	38791-38793	,	denotes	,
T9683	38793-38795	PRP	denotes	we
T9684	38807-38810	DT	denotes	the
T9685	38811-38815	NNS	denotes	mice
T9686	38816-38818	IN	denotes	in
T9687	38819-38822	DT	denotes	the
T9688	38831-38837	NN	denotes	strain
T9689	38823-38826	CD	denotes	129
T9690	38827-38830	NN	denotes	SvJ
T9691	38826-38827	HYPH	denotes	/
T9692	38838-38841	CC	denotes	and
T9693	38842-38850	VBD	denotes	observed
T9694	38851-38852	DT	denotes	a
T9695	38861-38870	NN	denotes	phenotype
T9696	38853-38860	JJ	denotes	similar
T9697	38870-38871	.	denotes	.
T9732	38873-38883	NN	denotes	Genotyping
T9733	38884-38887	CC	denotes	and
T9734	38888-38898	NN	denotes	immunoblot
T9735	38899-38907	NNS	denotes	analyses
T9736	38907-38908	.	denotes	.
T9737	38908-39047	sentence	denotes	All mouse procedures were performed in accordance with McGill University guidelines, which are set by the Canadian Council on Animal Care.
T9738	38909-38912	DT	denotes	All
T9739	38919-38929	NNS	denotes	procedures
T9740	38913-38918	NN	denotes	mouse
T9741	38935-38944	VBN	denotes	performed
T9742	38930-38934	VBD	denotes	were
T9743	38945-38947	IN	denotes	in
T9744	38948-38958	NN	denotes	accordance
T9745	38959-38963	IN	denotes	with
T9746	38964-38970	NNP	denotes	McGill
T9747	38971-38981	NNP	denotes	University
T9748	38982-38992	NNS	denotes	guidelines
T9749	38992-38994	,	denotes	,
T9750	38994-38999	WDT	denotes	which
T9751	39004-39007	VBN	denotes	set
T9752	39000-39003	VBP	denotes	are
T9753	39008-39010	IN	denotes	by
T9754	39011-39014	DT	denotes	the
T9755	39024-39031	NNP	denotes	Council
T9756	39015-39023	NNP	denotes	Canadian
T9757	39032-39034	IN	denotes	on
T9758	39035-39041	NNP	denotes	Animal
T9759	39042-39046	NNP	denotes	Care
T9760	39046-39047	.	denotes	.
T9761	39047-39151	sentence	denotes	Genomic DNA was isolated from tail biopsies and analyzed by Southern blotting and genomic PCR analysis.
T9762	39048-39055	JJ	denotes	Genomic
T9763	39056-39059	NN	denotes	DNA
T9764	39064-39072	VBN	denotes	isolated
T9765	39060-39063	VBD	denotes	was
T9766	39073-39077	IN	denotes	from
T9767	39078-39082	NN	denotes	tail
T9768	39083-39091	NNS	denotes	biopsies
T9769	39092-39095	CC	denotes	and
T9770	39096-39104	VBN	denotes	analyzed
T9771	39105-39107	IN	denotes	by
T9772	39108-39116	NNP	denotes	Southern
T9773	39117-39125	NN	denotes	blotting
T9774	39126-39129	CC	denotes	and
T9775	39130-39137	JJ	denotes	genomic
T9776	39142-39150	NN	denotes	analysis
T9777	39138-39141	NN	denotes	PCR
T9778	39150-39151	.	denotes	.
T9779	39151-39353	sentence	denotes	The DNA fragment utilized as the probe for the Southern blotting analysis was amplified with the following two oligonucleotides (5′-AAG CCT TTA CTG GTT GTG T-3′) and (5′-CTT GAA ACG CAC CGT AGG CT-3′).
T9780	39152-39155	DT	denotes	The
T9781	39160-39168	NN	denotes	fragment
T9782	39156-39159	NN	denotes	DNA
T9783	39230-39239	VBN	denotes	amplified
T9784	39169-39177	VBN	denotes	utilized
T9785	39178-39180	IN	denotes	as
T9786	39181-39184	DT	denotes	the
T9787	39185-39190	NN	denotes	probe
T9788	39191-39194	IN	denotes	for
T9789	39195-39198	DT	denotes	the
T9790	39217-39225	NN	denotes	analysis
T9791	39199-39207	NNP	denotes	Southern
T9792	39208-39216	NN	denotes	blotting
T9793	39226-39229	VBD	denotes	was
T9794	39240-39244	IN	denotes	with
T9795	39245-39248	DT	denotes	the
T9796	39263-39279	NNS	denotes	oligonucleotides
T9797	39249-39258	VBG	denotes	following
T9798	39259-39262	CD	denotes	two
T9799	39280-39281	-LRB-	denotes	(
T9800	39281-39282	CD	denotes	5
T9801	39282-39283	SYM	denotes	′
T9802	39283-39284	HYPH	denotes	-
T9803	39284-39287	NN	denotes	AAG
T9804	39308-39309	NN	denotes	T
T9805	39288-39291	NN	denotes	CCT
T9806	39292-39295	NN	denotes	TTA
T9807	39296-39299	NN	denotes	CTG
T9808	39300-39303	NN	denotes	GTT
T9809	39304-39307	NN	denotes	GTG
T9810	39309-39310	HYPH	denotes	-
T9811	39310-39311	CD	denotes	3
T9812	39311-39312	SYM	denotes	′
T9813	39312-39313	-RRB-	denotes	)
T9814	39314-39317	CC	denotes	and
T9815	39318-39319	-LRB-	denotes	(
T9816	39319-39320	CD	denotes	5
T9817	39320-39321	SYM	denotes	′
T9818	39321-39322	HYPH	denotes	-
T9819	39322-39325	NN	denotes	CTT
T9820	39346-39348	NN	denotes	CT
T9821	39326-39329	NN	denotes	GAA
T9822	39330-39333	NN	denotes	ACG
T9823	39334-39337	NN	denotes	CAC
T9824	39338-39341	NN	denotes	CGT
T9825	39342-39345	NN	denotes	AGG
T9826	39348-39349	HYPH	denotes	-
T9827	39349-39350	CD	denotes	3
T9828	39350-39351	SYM	denotes	′
T9829	39351-39352	-RRB-	denotes	)
T9830	39352-39353	.	denotes	.
T9831	39353-39527	sentence	denotes	The wild-type sam68 allele was identified by genomic PCR using the following oligonucleotides 5′-AAA TCC TAA CCC TCC TCA GTC AG-3′ and 5′-GAT ATG ATG GAT GAT ATC TGT CAG-3′.
T9832	39354-39357	DT	denotes	The
T9833	39374-39380	NN	denotes	allele
T9834	39358-39362	JJ	denotes	wild
T9835	39363-39367	NN	denotes	type
T9836	39362-39363	HYPH	denotes	-
T9837	39368-39373	NN	denotes	sam68
T9838	39385-39395	VBN	denotes	identified
T9839	39381-39384	VBD	denotes	was
T9840	39396-39398	IN	denotes	by
T9841	39399-39406	JJ	denotes	genomic
T9842	39407-39410	NN	denotes	PCR
T9843	39411-39416	VBG	denotes	using
T9844	39417-39420	DT	denotes	the
T9845	39431-39447	NNS	denotes	oligonucleotides
T9846	39421-39430	VBG	denotes	following
T9847	39448-39449	CD	denotes	5
T9848	39449-39450	SYM	denotes	′
T9849	39450-39451	HYPH	denotes	-
T9850	39451-39454	NN	denotes	AAA
T9851	39479-39481	NN	denotes	AG
T9852	39455-39458	NN	denotes	TCC
T9853	39459-39462	NN	denotes	TAA
T9854	39463-39466	NN	denotes	CCC
T9855	39467-39470	NN	denotes	TCC
T9856	39471-39474	NN	denotes	TCA
T9857	39475-39478	NN	denotes	GTC
T9858	39481-39482	HYPH	denotes	-
T9859	39482-39483	CD	denotes	3
T9860	39483-39484	SYM	denotes	′
T9861	39485-39488	CC	denotes	and
T9862	39489-39490	CD	denotes	5
T9863	39490-39491	SYM	denotes	′
T9864	39491-39492	HYPH	denotes	-
T9865	39492-39495	NN	denotes	GAT
T9866	39520-39523	NN	denotes	CAG
T9867	39496-39499	NN	denotes	ATG
T9868	39500-39503	NN	denotes	ATG
T9869	39504-39507	NN	denotes	GAT
T9870	39508-39511	NN	denotes	GAT
T9871	39512-39515	NN	denotes	ATC
T9872	39516-39519	NN	denotes	TGT
T9873	39523-39524	HYPH	denotes	-
T9874	39524-39525	CD	denotes	3
T9875	39525-39526	SYM	denotes	′
T9876	39526-39527	.	denotes	.
T9877	39527-39695	sentence	denotes	The sam68-targeted allele was identified by genomic PCR using the following oligonucleotides 5′-CTT GGG TGG AGA GGC TAT TCG-3′ and 5′-GTC GGG CAT GCG CGC CTT GAG C-3′.
T9878	39528-39531	DT	denotes	The
T9879	39547-39553	NN	denotes	allele
T9880	39532-39537	NN	denotes	sam68
T9881	39538-39546	VBN	denotes	targeted
T9882	39537-39538	HYPH	denotes	-
T9883	39558-39568	VBN	denotes	identified
T9884	39554-39557	VBD	denotes	was
T9885	39569-39571	IN	denotes	by
T9886	39572-39579	JJ	denotes	genomic
T9887	39580-39583	NN	denotes	PCR
T9888	39584-39589	VBG	denotes	using
T9889	39590-39593	DT	denotes	the
T9890	39604-39620	NNS	denotes	oligonucleotides
T9891	39594-39603	VBG	denotes	following
T9892	39621-39622	CD	denotes	5
T9893	39622-39623	SYM	denotes	′
T9894	39623-39624	HYPH	denotes	-
T9895	39624-39627	NN	denotes	CTT
T9896	39648-39651	NN	denotes	TCG
T9897	39628-39631	NN	denotes	GGG
T9898	39632-39635	NN	denotes	TGG
T9899	39636-39639	NN	denotes	AGA
T9900	39640-39643	NN	denotes	GGC
T9901	39644-39647	NN	denotes	TAT
T9902	39651-39652	HYPH	denotes	-
T9903	39652-39653	CD	denotes	3
T9904	39653-39654	SYM	denotes	′
T9905	39655-39658	CC	denotes	and
T9906	39659-39660	CD	denotes	5
T9907	39660-39661	SYM	denotes	′
T9908	39661-39662	HYPH	denotes	-
T9909	39662-39665	NN	denotes	GTC
T9910	39690-39691	NN	denotes	C
T9911	39666-39669	NN	denotes	GGG
T9912	39670-39673	NN	denotes	CAT
T9913	39674-39677	NN	denotes	GCG
T9914	39678-39681	NN	denotes	CGC
T9915	39682-39685	NN	denotes	CTT
T9916	39686-39689	NN	denotes	GAG
T9917	39691-39692	HYPH	denotes	-
T9918	39692-39693	CD	denotes	3
T9919	39693-39694	SYM	denotes	′
T9920	39694-39695	.	denotes	.
T9978	39697-39706	NN	denotes	Radiology
T9979	39707-39710	CC	denotes	and
T9980	39711-39716	NN	denotes	serum
T9981	39717-39729	NN	denotes	biochemistry
T9982	39730-39732	IN	denotes	on
T9983	39733-39738	NN	denotes	Sam68
T9984	39755-39759	NNS	denotes	mice
T9985	39738-39739	SYM	denotes	+
T9986	39739-39740	HYPH	denotes	/
T9987	39740-39741	SYM	denotes	+
T9988	39742-39745	CC	denotes	and
T9989	39746-39751	NN	denotes	Sam68
T9990	39751-39752	SYM	denotes	−
T9991	39752-39753	HYPH	denotes	/
T9992	39753-39754	SYM	denotes	−
T9993	39759-39760	.	denotes	.
T9994	39760-39848	sentence	denotes	Radiography, BMD, and micro-CT were performed essentially as described previously [63].
T9995	39761-39772	NN	denotes	Radiography
T9996	39797-39806	VBN	denotes	performed
T9997	39772-39774	,	denotes	,
T9998	39774-39777	NN	denotes	BMD
T9999	39777-39779	,	denotes	,
T10000	39779-39782	CC	denotes	and
T10001	39783-39791	NN	denotes	micro-CT
T10002	39792-39796	VBD	denotes	were
T10003	39807-39818	RB	denotes	essentially
T10004	39822-39831	VBN	denotes	described
T10005	39819-39821	IN	denotes	as
T10006	39832-39842	RB	denotes	previously
T10007	39843-39844	-LRB-	denotes	[
T10008	39844-39846	CD	denotes	63
T10009	39846-39847	-RRB-	denotes	]
T10010	39847-39848	.	denotes	.
T10011	39848-40055	sentence	denotes	Mice were administered a lethal dose of anesthetic at the indicated times, exsanguinated, and imaged using a Faxitron MX20 equipped with an FPX-2 Imaging system (Dalsa Medoptics, Waterloo, Ontario, Canada).
T10012	39849-39853	NNS	denotes	Mice
T10013	39859-39871	VBN	denotes	administered
T10014	39854-39858	VBD	denotes	were
T10015	39872-39873	DT	denotes	a
T10016	39881-39885	NN	denotes	dose
T10017	39874-39880	JJ	denotes	lethal
T10018	39886-39888	IN	denotes	of
T10019	39889-39899	JJ	denotes	anesthetic
T10020	39900-39902	IN	denotes	at
T10021	39903-39906	DT	denotes	the
T10022	39917-39922	NNS	denotes	times
T10023	39907-39916	VBN	denotes	indicated
T10024	39922-39924	,	denotes	,
T10025	39924-39937	VBN	denotes	exsanguinated
T10026	39937-39939	,	denotes	,
T10027	39939-39942	CC	denotes	and
T10028	39943-39949	VBN	denotes	imaged
T10029	39950-39955	VBG	denotes	using
T10030	39956-39957	DT	denotes	a
T10031	39967-39971	NNP	denotes	MX20
T10032	39958-39966	NNP	denotes	Faxitron
T10033	39972-39980	VBN	denotes	equipped
T10034	39981-39985	IN	denotes	with
T10035	39986-39988	DT	denotes	an
T10036	40003-40009	NN	denotes	system
T10037	39989-39992	NN	denotes	FPX
T10038	39992-39993	HYPH	denotes	-
T10039	39993-39994	CD	denotes	2
T10040	39995-40002	NN	denotes	Imaging
T10041	40010-40011	-LRB-	denotes	(
T10042	40017-40026	NNP	denotes	Medoptics
T10043	40011-40016	NNP	denotes	Dalsa
T10044	40026-40028	,	denotes	,
T10045	40028-40036	NNP	denotes	Waterloo
T10046	40036-40038	,	denotes	,
T10047	40038-40045	NNP	denotes	Ontario
T10048	40045-40047	,	denotes	,
T10049	40047-40053	NNP	denotes	Canada
T10050	40053-40054	-RRB-	denotes	)
T10051	40054-40055	.	denotes	.
T10052	40055-40167	sentence	denotes	Body fat, BMC, and BMD were evaluated using a Lunar PixiMUS 1.46 (GE-Lunar, Madison, Wisconsin, United States).
T10053	40056-40060	NN	denotes	Body
T10054	40061-40064	NN	denotes	fat
T10055	40084-40093	VBN	denotes	evaluated
T10056	40064-40066	,	denotes	,
T10057	40066-40069	NN	denotes	BMC
T10058	40069-40071	,	denotes	,
T10059	40071-40074	CC	denotes	and
T10060	40075-40078	NN	denotes	BMD
T10061	40079-40083	VBD	denotes	were
T10062	40094-40099	VBG	denotes	using
T10063	40100-40101	DT	denotes	a
T10064	40108-40115	NNP	denotes	PixiMUS
T10065	40102-40107	NNP	denotes	Lunar
T10066	40116-40120	CD	denotes	1.46
T10067	40121-40122	-LRB-	denotes	(
T10068	40125-40130	NNP	denotes	Lunar
T10069	40122-40124	NNP	denotes	GE
T10070	40124-40125	HYPH	denotes	-
T10071	40130-40132	,	denotes	,
T10072	40132-40139	NNP	denotes	Madison
T10073	40139-40141	,	denotes	,
T10074	40141-40150	NNP	denotes	Wisconsin
T10075	40150-40152	,	denotes	,
T10076	40152-40158	NNP	denotes	United
T10077	40159-40165	NNP	denotes	States
T10078	40165-40166	-RRB-	denotes	)
T10079	40166-40167	.	denotes	.
T10080	40167-40308	sentence	denotes	Morphometric parameters were determined on anesthetized mice at the time of sacrifice by direct measurement or from the Faxitron radiograph.
T10081	40168-40180	JJ	denotes	Morphometric
T10082	40181-40191	NNS	denotes	parameters
T10083	40197-40207	VBN	denotes	determined
T10084	40192-40196	VBD	denotes	were
T10085	40208-40210	IN	denotes	on
T10086	40211-40223	VBN	denotes	anesthetized
T10087	40224-40228	NNS	denotes	mice
T10088	40229-40231	IN	denotes	at
T10089	40232-40235	DT	denotes	the
T10090	40236-40240	NN	denotes	time
T10091	40241-40243	IN	denotes	of
T10092	40244-40253	NN	denotes	sacrifice
T10093	40254-40256	IN	denotes	by
T10094	40257-40263	JJ	denotes	direct
T10095	40264-40275	NN	denotes	measurement
T10096	40276-40278	CC	denotes	or
T10097	40279-40283	IN	denotes	from
T10098	40284-40287	DT	denotes	the
T10099	40297-40307	NN	denotes	radiograph
T10100	40288-40296	NNP	denotes	Faxitron
T10101	40307-40308	.	denotes	.
T10102	40308-40453	sentence	denotes	Micro-CT was performed on the left femur and fourth lumbar vertebra after removal of soft tissues and overnight fixation in 4% paraformaldehyde.
T10103	40309-40317	NN	denotes	Micro-CT
T10104	40322-40331	VBN	denotes	performed
T10105	40318-40321	VBD	denotes	was
T10106	40332-40334	IN	denotes	on
T10107	40335-40338	DT	denotes	the
T10108	40344-40349	NN	denotes	femur
T10109	40339-40343	JJ	denotes	left
T10110	40350-40353	CC	denotes	and
T10111	40354-40360	JJ	denotes	fourth
T10112	40368-40376	NN	denotes	vertebra
T10113	40361-40367	NN	denotes	lumbar
T10114	40377-40382	IN	denotes	after
T10115	40383-40390	NN	denotes	removal
T10116	40391-40393	IN	denotes	of
T10117	40394-40398	JJ	denotes	soft
T10118	40399-40406	NNS	denotes	tissues
T10119	40407-40410	CC	denotes	and
T10120	40411-40420	JJ	denotes	overnight
T10121	40421-40429	NN	denotes	fixation
T10122	40430-40432	IN	denotes	in
T10123	40433-40434	CD	denotes	4
T10124	40434-40435	NN	denotes	%
T10125	40436-40452	NN	denotes	paraformaldehyde
T10126	40452-40453	.	denotes	.
T10127	40453-40556	sentence	denotes	The distal metaphysis was scanned with a Skyscan 1072 micro-CT instrument (Skyscan, Antwerp, Belgium).
T10128	40454-40457	DT	denotes	The
T10129	40465-40475	NN	denotes	metaphysis
T10130	40458-40464	JJ	denotes	distal
T10131	40480-40487	VBN	denotes	scanned
T10132	40476-40479	VBD	denotes	was
T10133	40488-40492	IN	denotes	with
T10134	40493-40494	DT	denotes	a
T10135	40517-40527	NN	denotes	instrument
T10136	40495-40502	NNP	denotes	Skyscan
T10137	40503-40507	CD	denotes	1072
T10138	40508-40516	NN	denotes	micro-CT
T10139	40528-40529	-LRB-	denotes	(
T10140	40529-40536	NNP	denotes	Skyscan
T10141	40536-40538	,	denotes	,
T10142	40538-40545	NNP	denotes	Antwerp
T10143	40545-40547	,	denotes	,
T10144	40547-40554	NNP	denotes	Belgium
T10145	40554-40555	-RRB-	denotes	)
T10146	40555-40556	.	denotes	.
T10147	40556-40646	sentence	denotes	Image acquisition was performed at 100 kV and 98 μA, with a 0.9° rotation between frames.
T10148	40557-40562	NN	denotes	Image
T10149	40563-40574	NN	denotes	acquisition
T10150	40579-40588	VBN	denotes	performed
T10151	40575-40578	VBD	denotes	was
T10152	40589-40591	IN	denotes	at
T10153	40592-40595	CD	denotes	100
T10154	40596-40598	NN	denotes	kV
T10155	40599-40602	CC	denotes	and
T10156	40603-40605	CD	denotes	98
T10157	40606-40608	NN	denotes	μA
T10158	40608-40610	,	denotes	,
T10159	40610-40614	IN	denotes	with
T10160	40615-40616	DT	denotes	a
T10161	40622-40630	NN	denotes	rotation
T10162	40617-40620	CD	denotes	0.9
T10163	40620-40621	NN	denotes	°
T10164	40631-40638	IN	denotes	between
T10165	40639-40645	NNS	denotes	frames
T10166	40645-40646	.	denotes	.
T10167	40646-40816	sentence	denotes	The two-dimensional images were used to generate three-dimensional reconstructions to obtain quantitative data with the 3D Creator software supplied with the instrument.
T10168	40647-40650	DT	denotes	The
T10169	40667-40673	NNS	denotes	images
T10170	40651-40654	CD	denotes	two
T10171	40655-40666	JJ	denotes	dimensional
T10172	40654-40655	HYPH	denotes	-
T10173	40679-40683	VBN	denotes	used
T10174	40674-40678	VBD	denotes	were
T10175	40684-40686	TO	denotes	to
T10176	40687-40695	VB	denotes	generate
T10177	40696-40701	CD	denotes	three
T10178	40702-40713	JJ	denotes	dimensional
T10179	40701-40702	HYPH	denotes	-
T10180	40714-40729	NNS	denotes	reconstructions
T10181	40730-40732	TO	denotes	to
T10182	40733-40739	VB	denotes	obtain
T10183	40740-40752	JJ	denotes	quantitative
T10184	40753-40757	NNS	denotes	data
T10185	40758-40762	IN	denotes	with
T10186	40763-40766	DT	denotes	the
T10187	40778-40786	NN	denotes	software
T10188	40767-40769	JJ	denotes	3D
T10189	40770-40777	NN	denotes	Creator
T10190	40787-40795	VBN	denotes	supplied
T10191	40796-40800	IN	denotes	with
T10192	40801-40804	DT	denotes	the
T10193	40805-40815	NN	denotes	instrument
T10194	40815-40816	.	denotes	.
T10195	40816-40981	sentence	denotes	Serum biochemistry (ALP, Ca, PO4, Mg) was determined at the Rodent Diagnostics Lab (McGill University, Montréal, Quebec, Canada) using routine automated techniques.
T10196	40817-40822	NN	denotes	Serum
T10197	40823-40835	NN	denotes	biochemistry
T10198	40859-40869	VBN	denotes	determined
T10199	40836-40837	-LRB-	denotes	(
T10200	40851-40853	NN	denotes	Mg
T10201	40837-40840	NN	denotes	ALP
T10202	40840-40842	,	denotes	,
T10203	40842-40844	NN	denotes	Ca
T10204	40844-40846	,	denotes	,
T10205	40846-40849	NN	denotes	PO4
T10206	40849-40851	,	denotes	,
T10207	40853-40854	-RRB-	denotes	)
T10208	40855-40858	VBD	denotes	was
T10209	40870-40872	IN	denotes	at
T10210	40873-40876	DT	denotes	the
T10211	40896-40899	NNP	denotes	Lab
T10212	40877-40883	NNP	denotes	Rodent
T10213	40884-40895	NNP	denotes	Diagnostics
T10214	40900-40901	-LRB-	denotes	(
T10215	40908-40918	NNP	denotes	University
T10216	40901-40907	NNP	denotes	McGill
T10217	40918-40920	,	denotes	,
T10218	40920-40928	NNP	denotes	Montréal
T10219	40928-40930	,	denotes	,
T10220	40930-40936	NNP	denotes	Quebec
T10221	40936-40938	,	denotes	,
T10222	40938-40944	NNP	denotes	Canada
T10223	40944-40945	-RRB-	denotes	)
T10224	40946-40951	VBG	denotes	using
T10225	40952-40959	JJ	denotes	routine
T10226	40970-40980	NNS	denotes	techniques
T10227	40960-40969	VBN	denotes	automated
T10228	40980-40981	.	denotes	.
T10229	40981-41233	sentence	denotes	Commercial assays were used to determine serum levels of CTX (RatLaps ELISA, Nordic Bioscience), 17β estradiol (IBL Immuno-Biological, Hamburg, Germany), leptin (R & D Systems, Minneapolis, Minnesota, United States), and interleukin-6 (R & D Systems).
T10230	40982-40992	JJ	denotes	Commercial
T10231	40993-40999	NNS	denotes	assays
T10232	41005-41009	VBN	denotes	used
T10233	41000-41004	VBD	denotes	were
T10234	41010-41012	TO	denotes	to
T10235	41013-41022	VB	denotes	determine
T10236	41023-41028	NN	denotes	serum
T10237	41029-41035	NNS	denotes	levels
T10238	41036-41038	IN	denotes	of
T10239	41039-41042	NN	denotes	CTX
T10240	41043-41044	-LRB-	denotes	(
T10241	41052-41057	NNP	denotes	ELISA
T10242	41044-41051	NNP	denotes	RatLaps
T10243	41057-41059	,	denotes	,
T10244	41059-41065	NNP	denotes	Nordic
T10245	41066-41076	NNP	denotes	Bioscience
T10246	41076-41077	-RRB-	denotes	)
T10247	41077-41079	,	denotes	,
T10248	41079-41082	CD	denotes	17β
T10249	41083-41092	NN	denotes	estradiol
T10250	41093-41094	-LRB-	denotes	(
T10251	41098-41115	NNP	denotes	Immuno-Biological
T10252	41094-41097	NNP	denotes	IBL
T10253	41115-41117	,	denotes	,
T10254	41117-41124	NNP	denotes	Hamburg
T10255	41124-41126	,	denotes	,
T10256	41126-41133	NNP	denotes	Germany
T10257	41133-41134	-RRB-	denotes	)
T10258	41134-41136	,	denotes	,
T10259	41136-41142	NN	denotes	leptin
T10260	41143-41144	-LRB-	denotes	(
T10261	41150-41157	NNP	denotes	Systems
T10262	41144-41145	NNP	denotes	R
T10263	41146-41147	CC	denotes	&
T10264	41148-41149	NNP	denotes	D
T10265	41157-41159	,	denotes	,
T10266	41159-41170	NNP	denotes	Minneapolis
T10267	41170-41172	,	denotes	,
T10268	41172-41181	NNP	denotes	Minnesota
T10269	41181-41183	,	denotes	,
T10270	41183-41189	NNP	denotes	United
T10271	41190-41196	NNP	denotes	States
T10272	41196-41197	-RRB-	denotes	)
T10273	41197-41199	,	denotes	,
T10274	41199-41202	CC	denotes	and
T10275	41203-41214	NN	denotes	interleukin
T10276	41214-41215	HYPH	denotes	-
T10277	41215-41216	CD	denotes	6
T10278	41217-41218	-LRB-	denotes	(
T10279	41224-41231	NNP	denotes	Systems
T10280	41218-41219	NNP	denotes	R
T10281	41220-41221	CC	denotes	&
T10282	41222-41223	NNP	denotes	D
T10283	41231-41232	-RRB-	denotes	)
T10284	41232-41233	.	denotes	.
T10388	41235-41237	FW	denotes	Ex
T10389	41238-41242	FW	denotes	vivo
T10390	41243-41253	NN	denotes	assessment
T10391	41254-41256	IN	denotes	of
T10392	41257-41267	NN	denotes	osteoblast
T10393	41283-41291	NN	denotes	activity
T10394	41268-41271	CC	denotes	and
T10395	41272-41282	NN	denotes	osteoclast
T10396	41291-41292	.	denotes	.
T10397	41292-41499	sentence	denotes	Bone marrow was flushed from the tibia and femora of juvenile 4-week-old Sam68+/+ and Sam68−/− mice to obtain stromal cells that were maintained in differentiation medium for 6 or 18 days as described [63].
T10398	41293-41297	NN	denotes	Bone
T10399	41298-41304	NN	denotes	marrow
T10400	41309-41316	VBN	denotes	flushed
T10401	41305-41308	VBD	denotes	was
T10402	41317-41321	IN	denotes	from
T10403	41322-41325	DT	denotes	the
T10404	41326-41331	NN	denotes	tibia
T10405	41332-41335	CC	denotes	and
T10406	41336-41342	NNS	denotes	femora
T10407	41343-41345	IN	denotes	of
T10408	41346-41354	JJ	denotes	juvenile
T10409	41388-41392	NNS	denotes	mice
T10410	41355-41356	CD	denotes	4
T10411	41357-41361	NN	denotes	week
T10412	41356-41357	HYPH	denotes	-
T10413	41362-41365	JJ	denotes	old
T10414	41361-41362	HYPH	denotes	-
T10415	41366-41371	NN	denotes	Sam68
T10416	41371-41372	SYM	denotes	+
T10417	41372-41373	HYPH	denotes	/
T10419	41375-41378	CC	denotes	and
T10420	41379-41384	NN	denotes	Sam68
T10421	41384-41385	SYM	denotes	−
T10422	41385-41386	HYPH	denotes	/
T10423	41386-41387	SYM	denotes	−
T10424	41393-41395	TO	denotes	to
T10425	41396-41402	VB	denotes	obtain
T10426	41403-41410	JJ	denotes	stromal
T10427	41411-41416	NNS	denotes	cells
T10428	41417-41421	WDT	denotes	that
T10429	41427-41437	VBN	denotes	maintained
T10430	41422-41426	VBD	denotes	were
T10431	41438-41440	IN	denotes	in
T10432	41441-41456	NN	denotes	differentiation
T10433	41457-41463	NN	denotes	medium
T10434	41464-41467	IN	denotes	for
T10435	41468-41469	CD	denotes	6
T10436	41476-41480	NNS	denotes	days
T10437	41470-41472	CC	denotes	or
T10438	41473-41475	CD	denotes	18
T10439	41481-41483	IN	denotes	as
T10440	41484-41493	VBN	denotes	described
T10441	41494-41495	-LRB-	denotes	[
T10442	41495-41497	CD	denotes	63
T10443	41497-41498	-RRB-	denotes	]
T10444	41498-41499	.	denotes	.
T10445	41499-41602	sentence	denotes	Cultures were stained in situ for ALP activity and with von Kossa stain to detect mineralized nodules.
T10446	41500-41508	NNS	denotes	Cultures
T10447	41514-41521	VBN	denotes	stained
T10448	41509-41513	VBD	denotes	were
T10449	41522-41524	FW	denotes	in
T10450	41525-41529	FW	denotes	situ
T10451	41530-41533	IN	denotes	for
T10452	41534-41537	NN	denotes	ALP
T10453	41538-41546	NN	denotes	activity
T10454	41547-41550	CC	denotes	and
T10455	41551-41555	IN	denotes	with
T10456	41556-41559	NNP	denotes	von
T10457	41560-41565	NNP	denotes	Kossa
T10458	41566-41571	NN	denotes	stain
T10459	41572-41574	TO	denotes	to
T10460	41575-41581	VB	denotes	detect
T10461	41582-41593	VBN	denotes	mineralized
T10462	41594-41601	NNS	denotes	nodules
T10463	41601-41602	.	denotes	.
T10464	41602-41747	sentence	denotes	Total RNA was harvested from parallel cultures for RT-PCR analysis of osteoblast-related gene expression over time as described previously [63].
T10465	41603-41608	JJ	denotes	Total
T10466	41609-41612	NN	denotes	RNA
T10467	41617-41626	VBN	denotes	harvested
T10468	41613-41616	VBD	denotes	was
T10469	41627-41631	IN	denotes	from
T10470	41632-41640	JJ	denotes	parallel
T10471	41641-41649	NNS	denotes	cultures
T10472	41650-41653	IN	denotes	for
T10473	41654-41656	NN	denotes	RT
T10474	41657-41660	NN	denotes	PCR
T10475	41656-41657	HYPH	denotes	-
T10476	41661-41669	NN	denotes	analysis
T10477	41670-41672	IN	denotes	of
T10478	41673-41683	NN	denotes	osteoblast
T10479	41684-41691	VBN	denotes	related
T10480	41683-41684	HYPH	denotes	-
T10481	41697-41707	NN	denotes	expression
T10482	41692-41696	NN	denotes	gene
T10483	41708-41712	IN	denotes	over
T10484	41713-41717	NN	denotes	time
T10485	41718-41720	IN	denotes	as
T10486	41721-41730	VBN	denotes	described
T10487	41731-41741	RB	denotes	previously
T10488	41742-41743	-LRB-	denotes	[
T10489	41743-41745	CD	denotes	63
T10490	41745-41746	-RRB-	denotes	]
T10491	41746-41747	.	denotes	.
T10492	41747-41893	sentence	denotes	Osteoclasts were isolated from the crushed long bones of juvenile Sam68+/+ and Sam68−/− mice and used for quantitative studies as described [64].
T10493	41748-41759	NNS	denotes	Osteoclasts
T10494	41765-41773	VBN	denotes	isolated
T10495	41760-41764	VBD	denotes	were
T10496	41774-41778	IN	denotes	from
T10497	41779-41782	DT	denotes	the
T10498	41796-41801	NNS	denotes	bones
T10499	41783-41790	VBN	denotes	crushed
T10500	41791-41795	JJ	denotes	long
T10501	41802-41804	IN	denotes	of
T10502	41805-41813	JJ	denotes	juvenile
T10503	41836-41840	NNS	denotes	mice
T10504	41814-41819	NN	denotes	Sam68
T10505	41819-41820	SYM	denotes	+
T10506	41820-41821	HYPH	denotes	/
T10507	41821-41822	SYM	denotes	+
T10508	41823-41826	CC	denotes	and
T10509	41827-41832	NN	denotes	Sam68
T10510	41832-41833	SYM	denotes	−
T10511	41833-41834	HYPH	denotes	/
T10512	41834-41835	SYM	denotes	−
T10513	41841-41844	CC	denotes	and
T10514	41845-41849	VBN	denotes	used
T10515	41850-41853	IN	denotes	for
T10516	41854-41866	JJ	denotes	quantitative
T10517	41867-41874	NNS	denotes	studies
T10518	41875-41877	IN	denotes	as
T10519	41878-41887	VBN	denotes	described
T10520	41888-41889	-LRB-	denotes	[
T10521	41889-41891	CD	denotes	64
T10522	41891-41892	-RRB-	denotes	]
T10523	41892-41893	.	denotes	.
T10524	41893-42046	sentence	denotes	Briefly, cells were plated on glass coverslips or on dentin slices in 24-well cluster plates for assessment of cell number and pit number, respectively.
T10525	41894-41901	RB	denotes	Briefly
T10526	41914-41920	VBN	denotes	plated
T10527	41901-41903	,	denotes	,
T10528	41903-41908	NNS	denotes	cells
T10529	41909-41913	VBD	denotes	were
T10530	41921-41923	IN	denotes	on
T10531	41924-41929	NN	denotes	glass
T10532	41930-41940	NNS	denotes	coverslips
T10533	41941-41943	CC	denotes	or
T10534	41944-41946	IN	denotes	on
T10535	41947-41953	NN	denotes	dentin
T10536	41954-41960	NNS	denotes	slices
T10537	41961-41963	IN	denotes	in
T10538	41964-41966	CD	denotes	24
T10539	41967-41971	NN	denotes	well
T10540	41966-41967	HYPH	denotes	-
T10541	41980-41986	NNS	denotes	plates
T10542	41972-41979	NN	denotes	cluster
T10543	41987-41990	IN	denotes	for
T10544	41991-42001	NN	denotes	assessment
T10545	42002-42004	IN	denotes	of
T10546	42005-42009	NN	denotes	cell
T10547	42010-42016	NN	denotes	number
T10548	42017-42020	CC	denotes	and
T10549	42021-42024	NN	denotes	pit
T10550	42025-42031	NN	denotes	number
T10551	42031-42033	,	denotes	,
T10552	42033-42045	RB	denotes	respectively
T10553	42045-42046	.	denotes	.
T10554	42046-42136	sentence	denotes	Cover slips were immersed in 4% paraformaldehyde and stained for TRAP activity after 2 h.
T10555	42047-42052	NN	denotes	Cover
T10556	42053-42058	NNS	denotes	slips
T10557	42064-42072	VBN	denotes	immersed
T10558	42059-42063	VBD	denotes	were
T10559	42073-42075	IN	denotes	in
T10560	42076-42077	CD	denotes	4
T10561	42077-42078	NN	denotes	%
T10562	42079-42095	NN	denotes	paraformaldehyde
T10563	42096-42099	CC	denotes	and
T10564	42100-42107	VBN	denotes	stained
T10565	42108-42111	IN	denotes	for
T10566	42112-42116	NN	denotes	TRAP
T10567	42117-42125	NN	denotes	activity
T10568	42126-42131	IN	denotes	after
T10569	42132-42133	CD	denotes	2
T10570	42134-42135	NN	denotes	h
T10571	42135-42136	.	denotes	.
T10572	42136-42359	sentence	denotes	Dentin slices were left for 28 h before removing the cells with 1 M ammonium hydroxide and air drying before coating with sputter Au-Pd and examination with scanning electron microscopy (McGill Electron Microscopy Centre).
T10573	42137-42143	NN	denotes	Dentin
T10574	42144-42150	NNS	denotes	slices
T10575	42156-42160	VBN	denotes	left
T10576	42151-42155	VBD	denotes	were
T10577	42161-42164	IN	denotes	for
T10578	42165-42167	CD	denotes	28
T10579	42168-42169	NN	denotes	h
T10580	42170-42176	IN	denotes	before
T10581	42177-42185	VBG	denotes	removing
T10582	42186-42189	DT	denotes	the
T10583	42190-42195	NNS	denotes	cells
T10584	42196-42200	IN	denotes	with
T10585	42201-42202	CD	denotes	1
T10586	42203-42204	NN	denotes	M
T10587	42214-42223	NN	denotes	hydroxide
T10588	42205-42213	NN	denotes	ammonium
T10589	42224-42227	CC	denotes	and
T10590	42228-42231	NN	denotes	air
T10591	42232-42238	VBG	denotes	drying
T10592	42239-42245	IN	denotes	before
T10593	42246-42253	VBG	denotes	coating
T10594	42254-42258	IN	denotes	with
T10595	42259-42266	NN	denotes	sputter
T10596	42270-42272	NN	denotes	Pd
T10597	42267-42269	NN	denotes	Au
T10598	42269-42270	HYPH	denotes	-
T10599	42273-42276	CC	denotes	and
T10600	42277-42288	NN	denotes	examination
T10601	42289-42293	IN	denotes	with
T10602	42294-42302	VBG	denotes	scanning
T10603	42312-42322	NN	denotes	microscopy
T10604	42303-42311	NN	denotes	electron
T10605	42323-42324	-LRB-	denotes	(
T10606	42351-42357	NNP	denotes	Centre
T10607	42324-42330	NNP	denotes	McGill
T10608	42331-42339	NNP	denotes	Electron
T10609	42340-42350	NNP	denotes	Microscopy
T10610	42357-42358	-RRB-	denotes	)
T10611	42358-42359	.	denotes	.
T10612	42359-42462	sentence	denotes	Light microscope images were captured using a Leica DMR microscope equipped with a Retiga 1300 camera.
T10613	42360-42365	NN	denotes	Light
T10614	42366-42376	NN	denotes	microscope
T10615	42377-42383	NNS	denotes	images
T10616	42389-42397	VBN	denotes	captured
T10617	42384-42388	VBD	denotes	were
T10618	42398-42403	VBG	denotes	using
T10619	42404-42405	DT	denotes	a
T10620	42416-42426	NN	denotes	microscope
T10621	42406-42411	NNP	denotes	Leica
T10622	42412-42415	NNP	denotes	DMR
T10623	42427-42435	VBN	denotes	equipped
T10624	42436-42440	IN	denotes	with
T10625	42441-42442	DT	denotes	a
T10626	42455-42461	NN	denotes	camera
T10627	42443-42449	NNP	denotes	Retiga
T10628	42450-42454	CD	denotes	1300
T10629	42461-42462	.	denotes	.
T10630	42462-42602	sentence	denotes	Quantitative analyses were performed using Adobe Photoshop and the data presented as the mean ± SD of two or three independent experiments.
T10631	42463-42475	JJ	denotes	Quantitative
T10632	42476-42484	NNS	denotes	analyses
T10633	42490-42499	VBN	denotes	performed
T10634	42485-42489	VBD	denotes	were
T10635	42500-42505	VBG	denotes	using
T10636	42506-42511	NNP	denotes	Adobe
T10637	42512-42521	NNP	denotes	Photoshop
T10638	42522-42525	CC	denotes	and
T10639	42526-42529	DT	denotes	the
T10640	42530-42534	NNS	denotes	data
T10641	42535-42544	VBN	denotes	presented
T10642	42545-42547	IN	denotes	as
T10643	42548-42551	DT	denotes	the
T10644	42559-42561	NN	denotes	SD
T10645	42552-42556	NN	denotes	mean
T10646	42557-42558	SYM	denotes	±
T10647	42562-42564	IN	denotes	of
T10648	42565-42568	CD	denotes	two
T10649	42590-42601	NNS	denotes	experiments
T10650	42569-42571	CC	denotes	or
T10651	42572-42577	CD	denotes	three
T10652	42578-42589	JJ	denotes	independent
T10653	42601-42602	.	denotes	.
T10654	42602-42664	sentence	denotes	Statistical comparisons were made using the Student's t test.
T10655	42603-42614	JJ	denotes	Statistical
T10656	42615-42626	NNS	denotes	comparisons
T10657	42632-42636	VBN	denotes	made
T10658	42627-42631	VBD	denotes	were
T10659	42637-42642	VBG	denotes	using
T10660	42643-42646	DT	denotes	the
T10661	42647-42654	NNP	denotes	Student
T10662	42659-42663	NN	denotes	test
T10663	42654-42656	POS	denotes	's
T10664	42657-42658	NN	denotes	t
T10665	42663-42664	.	denotes	.
T10693	42666-42677	NN	denotes	Preparation
T10694	42678-42680	IN	denotes	of
T10695	42681-42686	NN	denotes	mouse
T10696	42697-42707	NN	denotes	fibroblast
T10697	42687-42696	JJ	denotes	embryonic
T10698	42708-42711	CC	denotes	and
T10699	42712-42721	NN	denotes	induction
T10700	42722-42724	IN	denotes	of
T10701	42725-42734	NN	denotes	adipocyte
T10702	42735-42750	NN	denotes	differentiation
T10703	42750-42751	.	denotes	.
T10704	42751-42797	sentence	denotes	MEFs were prepared from 14.5-day-old embryos.
T10705	42752-42756	NNS	denotes	MEFs
T10706	42762-42770	VBN	denotes	prepared
T10707	42757-42761	VBD	denotes	were
T10708	42771-42775	IN	denotes	from
T10709	42776-42780	CD	denotes	14.5
T10710	42781-42784	NN	denotes	day
T10711	42780-42781	HYPH	denotes	-
T10712	42785-42788	JJ	denotes	old
T10713	42784-42785	HYPH	denotes	-
T10714	42789-42796	NNS	denotes	embryos
T10715	42796-42797	.	denotes	.
T10716	42797-42972	sentence	denotes	Only early-passage MEFs were used for the experimental studies, and induction of adipocyte differentiation was carried out according to the methods previously described [30].
T10717	42798-42802	RB	denotes	Only
T10718	42817-42821	NNS	denotes	MEFs
T10719	42803-42808	JJ	denotes	early
T10720	42809-42816	NN	denotes	passage
T10721	42808-42809	HYPH	denotes	-
T10722	42827-42831	VBN	denotes	used
T10723	42822-42826	VBD	denotes	were
T10724	42832-42835	IN	denotes	for
T10725	42836-42839	DT	denotes	the
T10726	42853-42860	NNS	denotes	studies
T10727	42840-42852	JJ	denotes	experimental
T10728	42860-42862	,	denotes	,
T10729	42862-42865	CC	denotes	and
T10730	42866-42875	NN	denotes	induction
T10731	42909-42916	VBN	denotes	carried
T10732	42876-42878	IN	denotes	of
T10733	42879-42888	NN	denotes	adipocyte
T10734	42889-42904	NN	denotes	differentiation
T10735	42905-42908	VBD	denotes	was
T10736	42917-42920	RP	denotes	out
T10737	42921-42930	VBG	denotes	according
T10738	42931-42933	IN	denotes	to
T10739	42934-42937	DT	denotes	the
T10740	42938-42945	NNS	denotes	methods
T10741	42946-42956	RB	denotes	previously
T10742	42957-42966	VBN	denotes	described
T10743	42967-42968	-LRB-	denotes	[
T10744	42968-42970	CD	denotes	30
T10745	42970-42971	-RRB-	denotes	]
T10746	42971-42972	.	denotes	.
T10747	42972-43034	sentence	denotes	Cultured cells were stained with Oil Red O as described [29].
T10748	42973-42981	VBN	denotes	Cultured
T10749	42982-42987	NNS	denotes	cells
T10750	42993-43000	VBN	denotes	stained
T10751	42988-42992	VBD	denotes	were
T10752	43001-43005	IN	denotes	with
T10753	43006-43009	NN	denotes	Oil
T10754	43014-43015	NN	denotes	O
T10755	43010-43013	NN	denotes	Red
T10756	43016-43018	IN	denotes	as
T10757	43019-43028	VBN	denotes	described
T10758	43029-43030	-LRB-	denotes	[
T10759	43030-43032	CD	denotes	29
T10760	43032-43033	-RRB-	denotes	]
T10761	43033-43034	.	denotes	.
T10818	43036-43039	NN	denotes	RNA
T10819	43040-43051	NN	denotes	preparation
T10820	43052-43055	CC	denotes	and
T10821	43056-43058	NN	denotes	RT
T10822	43059-43062	NN	denotes	PCR
T10823	43058-43059	HYPH	denotes	-
T10824	43063-43065	TO	denotes	to
T10825	43066-43072	VB	denotes	assess
T10826	43073-43085	NN	denotes	adipogenesis
T10827	43086-43088	IN	denotes	in
T10828	43089-43094	NN	denotes	Sam68
T10829	43098-43102	NNS	denotes	MEFs
T10830	43094-43095	SYM	denotes	−
T10831	43095-43096	HYPH	denotes	/
T10832	43096-43097	SYM	denotes	−
T10833	43102-43103	.	denotes	.
T10834	43103-43245	sentence	denotes	Total cellular RNA was prepared by TRIzol reagent according to the manufacturer's protocol (Invitrogen, Carlsbad, California, United States).
T10835	43104-43109	JJ	denotes	Total
T10836	43119-43122	NN	denotes	RNA
T10837	43110-43118	JJ	denotes	cellular
T10838	43127-43135	VBN	denotes	prepared
T10839	43123-43126	VBD	denotes	was
T10840	43136-43138	IN	denotes	by
T10841	43139-43145	NN	denotes	TRIzol
T10842	43146-43153	NN	denotes	reagent
T10843	43154-43163	VBG	denotes	according
T10844	43164-43166	IN	denotes	to
T10845	43167-43170	DT	denotes	the
T10846	43171-43183	NN	denotes	manufacturer
T10847	43186-43194	NN	denotes	protocol
T10848	43183-43185	POS	denotes	's
T10849	43195-43196	-LRB-	denotes	(
T10850	43196-43206	NNP	denotes	Invitrogen
T10851	43206-43208	,	denotes	,
T10852	43208-43216	NNP	denotes	Carlsbad
T10853	43216-43218	,	denotes	,
T10854	43218-43228	NNP	denotes	California
T10855	43228-43230	,	denotes	,
T10856	43230-43236	NNP	denotes	United
T10857	43237-43243	NNP	denotes	States
T10858	43243-43244	-RRB-	denotes	)
T10859	43244-43245	.	denotes	.
T10860	43245-43327	sentence	denotes	Total RNA (1 μg) was reverse-transcribed, and cDNA samples were subjected to PCR.
T10861	43246-43251	JJ	denotes	Total
T10862	43252-43255	NN	denotes	RNA
T10863	43275-43286	VBN	denotes	transcribed
T10864	43256-43257	-LRB-	denotes	(
T10865	43259-43261	NN	denotes	μg
T10866	43257-43258	CD	denotes	1
T10867	43261-43262	-RRB-	denotes	)
T10868	43263-43266	VBD	denotes	was
T10869	43267-43274	RB	denotes	reverse
T10870	43274-43275	HYPH	denotes	-
T10871	43286-43288	,	denotes	,
T10872	43288-43291	CC	denotes	and
T10873	43292-43296	NN	denotes	cDNA
T10874	43297-43304	NNS	denotes	samples
T10875	43310-43319	VBN	denotes	subjected
T10876	43305-43309	VBD	denotes	were
T10877	43320-43322	IN	denotes	to
T10878	43323-43326	NN	denotes	PCR
T10879	43326-43327	.	denotes	.
T10880	43327-43388	sentence	denotes	RT-PCR was normalized by the transcriptional level of GAPDH.
T10881	43328-43330	NN	denotes	RT
T10882	43331-43334	NN	denotes	PCR
T10883	43330-43331	HYPH	denotes	-
T10884	43339-43349	VBN	denotes	normalized
T10885	43335-43338	VBD	denotes	was
T10886	43350-43352	IN	denotes	by
T10887	43353-43356	DT	denotes	the
T10888	43373-43378	NN	denotes	level
T10889	43357-43372	JJ	denotes	transcriptional
T10890	43379-43381	IN	denotes	of
T10891	43382-43387	NN	denotes	GAPDH
T10892	43387-43388	.	denotes	.
T10893	43388-43789	sentence	denotes	The following 5′ and 3′ primers were used to evaluate adipogenic differentiation: KLF5: 5'-AGA CAA GCT GAG ATG CTG C-3′, 5′-GGC AAA CCT CCA GTC GC-3′; PPARγ: 5′-GTG CGA TCA AAG TAG AAC CTG C-3′, 5′-CCT ATC ATA AAT AAG CTT CAA TCG-3′; β-Actin: 5′-TAG GCG GAC TGT TAC TGA GC-3′, 5′-AGC CTT CAT ACA TCA AGT TGG-3′; and Sam68: 5′- GTG GAG ACC CCA AAT ATG CCC A-3′ and 5′-AAA CTG CTC CTG ACA GAT ATC A-3′.
T10894	43389-43392	DT	denotes	The
T10895	43413-43420	NNS	denotes	primers
T10896	43393-43402	VBG	denotes	following
T10897	43403-43404	CD	denotes	5
T10898	43404-43405	SYM	denotes	′
T10899	43406-43409	CC	denotes	and
T10900	43410-43411	CD	denotes	3
T10901	43411-43412	SYM	denotes	′
T10902	43426-43430	VBN	denotes	used
T10903	43421-43425	VBD	denotes	were
T10904	43431-43433	TO	denotes	to
T10905	43434-43442	VB	denotes	evaluate
T10906	43443-43453	JJ	denotes	adipogenic
T10907	43454-43469	NN	denotes	differentiation
T10908	43469-43471	:	denotes	:
T10909	43471-43475	NN	denotes	KLF5
T10910	43475-43477	:	denotes	:
T10911	43477-43478	CD	denotes	5
T10912	43478-43479	SYM	denotes	'
T10913	43479-43480	HYPH	denotes	-
T10914	43480-43483	NN	denotes	AGA
T10915	43504-43505	NN	denotes	C
T10916	43484-43487	NN	denotes	CAA
T10917	43488-43491	NN	denotes	GCT
T10918	43492-43495	NN	denotes	GAG
T10919	43496-43499	NN	denotes	ATG
T10920	43500-43503	NN	denotes	CTG
T10921	43505-43506	HYPH	denotes	-
T10922	43506-43507	CD	denotes	3
T10923	43507-43508	SYM	denotes	′
T10924	43508-43510	,	denotes	,
T10925	43510-43511	CD	denotes	5
T10926	43511-43512	SYM	denotes	′
T10927	43512-43513	HYPH	denotes	-
T10928	43513-43516	NN	denotes	GGC
T10929	43533-43535	NN	denotes	GC
T10930	43517-43520	NN	denotes	AAA
T10931	43521-43524	NN	denotes	CCT
T10932	43525-43528	NN	denotes	CCA
T10933	43529-43532	NN	denotes	GTC
T10934	43535-43536	HYPH	denotes	-
T10935	43536-43537	CD	denotes	3
T10936	43537-43538	SYM	denotes	′
T10937	43538-43539	:	denotes	;
T10938	43540-43545	NN	denotes	PPARγ
T10939	43545-43547	:	denotes	:
T10940	43547-43548	CD	denotes	5
T10941	43548-43549	SYM	denotes	′
T10942	43549-43550	HYPH	denotes	-
T10943	43550-43553	NN	denotes	GTG
T10944	43578-43579	NN	denotes	C
T10945	43554-43557	NN	denotes	CGA
T10946	43558-43561	NN	denotes	TCA
T10947	43562-43565	NN	denotes	AAG
T10948	43566-43569	NN	denotes	TAG
T10949	43570-43573	NN	denotes	AAC
T10950	43574-43577	NN	denotes	CTG
T10951	43579-43580	HYPH	denotes	-
T10952	43580-43581	CD	denotes	3
T10953	43581-43582	SYM	denotes	′
T10954	43582-43584	,	denotes	,
T10955	43584-43585	CD	denotes	5
T10956	43585-43586	SYM	denotes	′
T10957	43586-43587	HYPH	denotes	-
T10958	43587-43590	NN	denotes	CCT
T10959	43615-43618	NN	denotes	TCG
T10960	43591-43594	NN	denotes	ATC
T10961	43595-43598	NN	denotes	ATA
T10962	43599-43602	NN	denotes	AAT
T10963	43603-43606	NN	denotes	AAG
T10964	43607-43610	NN	denotes	CTT
T10965	43611-43614	NN	denotes	CAA
T10966	43618-43619	HYPH	denotes	-
T10967	43619-43620	CD	denotes	3
T10968	43620-43621	SYM	denotes	′
T10969	43621-43622	:	denotes	;
T10970	43623-43624	NN	denotes	β
T10971	43625-43630	NN	denotes	Actin
T10972	43624-43625	HYPH	denotes	-
T10973	43630-43632	:	denotes	:
T10974	43632-43633	CD	denotes	5
T10975	43633-43634	SYM	denotes	′
T10976	43634-43635	HYPH	denotes	-
T10977	43635-43638	NN	denotes	TAG
T10978	43659-43661	NN	denotes	GC
T10979	43639-43642	NN	denotes	GCG
T10980	43643-43646	NN	denotes	GAC
T10981	43647-43650	NN	denotes	TGT
T10982	43651-43654	NN	denotes	TAC
T10983	43655-43658	NN	denotes	TGA
T10984	43661-43662	HYPH	denotes	-
T10985	43662-43663	CD	denotes	3
T10986	43663-43664	SYM	denotes	′
T10987	43664-43666	,	denotes	,
T10988	43666-43667	CD	denotes	5
T10989	43667-43668	SYM	denotes	′
T10990	43668-43669	HYPH	denotes	-
T10991	43669-43672	NN	denotes	AGC
T10992	43693-43696	NN	denotes	TGG
T10993	43673-43676	NN	denotes	CTT
T10994	43677-43680	NN	denotes	CAT
T10995	43681-43684	NN	denotes	ACA
T10996	43685-43688	NN	denotes	TCA
T10997	43689-43692	NN	denotes	AGT
T10998	43696-43697	HYPH	denotes	-
T10999	43697-43698	CD	denotes	3
T11000	43698-43699	SYM	denotes	′
T11001	43699-43700	:	denotes	;
T11002	43701-43704	CC	denotes	and
T11003	43705-43710	NN	denotes	Sam68
T11004	43710-43712	:	denotes	:
T11005	43712-43713	CD	denotes	5
T11006	43713-43714	SYM	denotes	′
T11007	43714-43715	HYPH	denotes	-
T11008	43716-43719	NN	denotes	GTG
T11009	43744-43745	NN	denotes	A
T11010	43720-43723	NN	denotes	GAG
T11011	43724-43727	NN	denotes	ACC
T11012	43728-43731	NN	denotes	CCA
T11013	43732-43735	NN	denotes	AAT
T11014	43736-43739	NN	denotes	ATG
T11015	43740-43743	NN	denotes	CCC
T11016	43745-43746	HYPH	denotes	-
T11017	43746-43747	CD	denotes	3
T11018	43747-43748	SYM	denotes	′
T11019	43749-43752	CC	denotes	and
T11020	43753-43754	CD	denotes	5
T11021	43754-43755	SYM	denotes	′
T11022	43755-43756	HYPH	denotes	-
T11023	43756-43759	NN	denotes	AAA
T11024	43784-43785	NN	denotes	A
T11025	43760-43763	NN	denotes	CTG
T11026	43764-43767	NN	denotes	CTC
T11027	43768-43771	NN	denotes	CTG
T11028	43772-43775	NN	denotes	ACA
T11029	43776-43779	NN	denotes	GAT
T11030	43780-43783	NN	denotes	ATC
T11031	43785-43786	HYPH	denotes	-
T11032	43786-43787	CD	denotes	3
T11033	43787-43788	SYM	denotes	′
T11034	43788-43789	.	denotes	.
T11076	43791-43796	NN	denotes	Sam68
T11077	43802-43812	NN	denotes	regulation
T11078	43797-43801	RB	denotes	down
T11079	43801-43802	HYPH	denotes	-
T11080	43813-43818	VBG	denotes	using
T11081	43819-43826	NN	denotes	Sam68sh
T11082	43826-43827	.	denotes	.
T11083	43827-43912	sentence	denotes	To generate an shRNA, 64-base duplex DNA nucleotides were purchased from Invitrogen.
T11084	43828-43830	TO	denotes	To
T11085	43831-43839	VB	denotes	generate
T11086	43886-43895	VBN	denotes	purchased
T11087	43840-43842	DT	denotes	an
T11088	43843-43848	NN	denotes	shRNA
T11089	43848-43850	,	denotes	,
T11090	43850-43852	CD	denotes	64
T11091	43853-43857	NN	denotes	base
T11092	43852-43853	HYPH	denotes	-
T11093	43869-43880	NNS	denotes	nucleotides
T11094	43858-43864	NN	denotes	duplex
T11095	43865-43868	NN	denotes	DNA
T11096	43881-43885	VBD	denotes	were
T11097	43896-43900	IN	denotes	from
T11098	43901-43911	NNP	denotes	Invitrogen
T11099	43911-43912	.	denotes	.
T11100	43912-44048	sentence	denotes	This fragment comprised 19 base residues specific to mouse Sam68 (GATCCCC AAGATGACGAGGAGAATTATTCAAGAGA TAATTCTCCTCGTCATCTT TTTTTGGAAA).
T11101	43913-43917	DT	denotes	This
T11102	43918-43926	NN	denotes	fragment
T11103	43927-43936	VBD	denotes	comprised
T11104	43937-43939	CD	denotes	19
T11105	43945-43953	NNS	denotes	residues
T11106	43940-43944	NN	denotes	base
T11107	43954-43962	JJ	denotes	specific
T11108	43963-43965	IN	denotes	to
T11109	43966-43971	NN	denotes	mouse
T11110	43972-43977	NN	denotes	Sam68
T11111	43978-43979	-LRB-	denotes	(
T11112	44036-44046	NN	denotes	TTTTTGGAAA
T11113	43979-43986	NN	denotes	GATCCCC
T11114	43987-44015	NN	denotes	AAGATGACGAGGAGAATTATTCAAGAGA
T11115	44016-44035	NN	denotes	TAATTCTCCTCGTCATCTT
T11116	44046-44047	-RRB-	denotes	)
T11117	44047-44048	.	denotes	.
T11118	44048-44142	sentence	denotes	This fragment was cloned into pSUPER retro (OligoEngine, Seattle, Washington, United States).
T11119	44049-44053	DT	denotes	This
T11120	44054-44062	NN	denotes	fragment
T11121	44067-44073	VBN	denotes	cloned
T11122	44063-44066	VBD	denotes	was
T11123	44074-44078	IN	denotes	into
T11124	44079-44085	NNP	denotes	pSUPER
T11125	44086-44091	NNP	denotes	retro
T11126	44092-44093	-LRB-	denotes	(
T11127	44093-44104	NNP	denotes	OligoEngine
T11128	44104-44106	,	denotes	,
T11129	44106-44113	NNP	denotes	Seattle
T11130	44113-44115	,	denotes	,
T11131	44115-44125	NNP	denotes	Washington
T11132	44125-44127	,	denotes	,
T11133	44127-44133	NNP	denotes	United
T11134	44134-44140	NNP	denotes	States
T11135	44140-44141	-RRB-	denotes	)
T11136	44141-44142	.	denotes	.
T11137	44142-44251	sentence	denotes	Transfections were performed using LipofectAMINE Plus (Invitrogen) with cloned DNA fragment or empty vector.
T11138	44143-44156	NNS	denotes	Transfections
T11139	44162-44171	VBN	denotes	performed
T11140	44157-44161	VBD	denotes	were
T11141	44172-44177	VBG	denotes	using
T11142	44178-44191	NNP	denotes	LipofectAMINE
T11143	44192-44196	NNP	denotes	Plus
T11144	44197-44198	-LRB-	denotes	(
T11145	44198-44208	NNP	denotes	Invitrogen
T11146	44208-44209	-RRB-	denotes	)
T11147	44210-44214	IN	denotes	with
T11148	44215-44221	VBN	denotes	cloned
T11149	44226-44234	NN	denotes	fragment
T11150	44222-44225	NN	denotes	DNA
T11151	44235-44237	CC	denotes	or
T11152	44238-44243	JJ	denotes	empty
T11153	44244-44250	NN	denotes	vector
T11154	44250-44251	.	denotes	.
T11155	44251-44406	sentence	denotes	At 48 h after transfection, populations were selected for 2.5 μg/ml puromycin and the knockdown observed by immunoblotting with anti-Sam68 (AD1) antibody.
T11156	44252-44254	IN	denotes	At
T11157	44297-44305	VBN	denotes	selected
T11158	44255-44257	CD	denotes	48
T11159	44258-44259	NN	denotes	h
T11160	44260-44265	IN	denotes	after
T11161	44266-44278	NN	denotes	transfection
T11162	44278-44280	,	denotes	,
T11163	44280-44291	NNS	denotes	populations
T11164	44292-44296	VBD	denotes	were
T11165	44306-44309	IN	denotes	for
T11166	44310-44313	CD	denotes	2.5
T11167	44314-44316	NN	denotes	μg
T11168	44320-44329	NN	denotes	puromycin
T11169	44316-44317	SYM	denotes	/
T11170	44317-44319	NN	denotes	ml
T11171	44330-44333	CC	denotes	and
T11172	44334-44337	DT	denotes	the
T11173	44338-44347	NN	denotes	knockdown
T11174	44348-44356	VBN	denotes	observed
T11175	44357-44359	IN	denotes	by
T11176	44360-44374	VBG	denotes	immunoblotting
T11177	44375-44379	IN	denotes	with
T11178	44380-44390	JJ	denotes	anti-Sam68
T11179	44397-44405	NN	denotes	antibody
T11180	44391-44392	-LRB-	denotes	(
T11181	44392-44395	NN	denotes	AD1
T11182	44395-44396	-RRB-	denotes	)
T11183	44405-44406	.	denotes	.
T11232	44408-44418	JJ	denotes	Osteogenic
T11233	44435-44443	NN	denotes	analysis
T11234	44419-44434	NN	denotes	differentiation
T11235	44444-44446	IN	denotes	of
T11236	44447-44454	NN	denotes	C3HT101
T11237	44457-44462	NNS	denotes	cells
T11238	44454-44455	HYPH	denotes	/
T11239	44455-44456	CD	denotes	2
T11240	44462-44463	.	denotes	.
T11241	44463-44592	sentence	denotes	For osteogenic differentiation, C3HT101/2 (ATCC) cells were incubated in 48-well tissue culture plates at 1.25 × 104 cells/cm2 .
T11242	44464-44467	IN	denotes	For
T11243	44524-44533	VBN	denotes	incubated
T11244	44468-44478	JJ	denotes	osteogenic
T11245	44479-44494	NN	denotes	differentiation
T11246	44494-44496	,	denotes	,
T11247	44496-44503	NN	denotes	C3HT101
T11248	44513-44518	NNS	denotes	cells
T11249	44503-44504	HYPH	denotes	/
T11250	44504-44505	CD	denotes	2
T11251	44506-44507	-LRB-	denotes	(
T11252	44507-44511	NN	denotes	ATCC
T11253	44511-44512	-RRB-	denotes	)
T11254	44519-44523	VBD	denotes	were
T11255	44534-44536	IN	denotes	in
T11256	44537-44539	CD	denotes	48
T11257	44540-44544	NN	denotes	well
T11258	44539-44540	HYPH	denotes	-
T11259	44560-44566	NNS	denotes	plates
T11260	44545-44551	NN	denotes	tissue
T11261	44552-44559	NN	denotes	culture
T11262	44567-44569	IN	denotes	at
T11263	44570-44574	CD	denotes	1.25
T11264	44577-44580	CD	denotes	104
T11265	44575-44576	SYM	denotes	×
T11266	44581-44586	NNS	denotes	cells
T11267	44586-44587	SYM	denotes	/
T11268	44587-44590	NN	denotes	cm2
T11269	44591-44592	.	denotes	.
T11270	44592-44733	sentence	denotes	After 24-h incubation, the culture media were changed to fresh media containing 300 ng/ml BMP-2 (Sigma, St. Louis, Missouri, United States).
T11271	44593-44598	IN	denotes	After
T11272	44639-44646	VBN	denotes	changed
T11273	44599-44601	CD	denotes	24
T11274	44602-44603	NN	denotes	h
T11275	44601-44602	HYPH	denotes	-
T11276	44604-44614	NN	denotes	incubation
T11277	44614-44616	,	denotes	,
T11278	44616-44619	DT	denotes	the
T11279	44628-44633	NNS	denotes	media
T11280	44620-44627	NN	denotes	culture
T11281	44634-44638	VBD	denotes	were
T11282	44647-44649	IN	denotes	to
T11283	44650-44655	JJ	denotes	fresh
T11284	44656-44661	NNS	denotes	media
T11285	44662-44672	VBG	denotes	containing
T11286	44673-44676	CD	denotes	300
T11287	44677-44679	NN	denotes	ng
T11288	44683-44686	NN	denotes	BMP
T11289	44679-44680	SYM	denotes	/
T11290	44680-44682	NN	denotes	ml
T11291	44686-44687	HYPH	denotes	-
T11292	44687-44688	CD	denotes	2
T11293	44689-44690	-LRB-	denotes	(
T11294	44690-44695	NNP	denotes	Sigma
T11295	44695-44697	,	denotes	,
T11296	44697-44700	NNP	denotes	St.
T11297	44701-44706	NNP	denotes	Louis
T11298	44706-44708	,	denotes	,
T11299	44708-44716	NNP	denotes	Missouri
T11300	44716-44718	,	denotes	,
T11301	44718-44724	NNP	denotes	United
T11302	44725-44731	NNP	denotes	States
T11303	44731-44732	-RRB-	denotes	)
T11304	44732-44733	.	denotes	.
T11305	44733-44904	sentence	denotes	Total cellular RNA was prepared as described above, and osteocalcin, β-actin, and GAPDH gene expression at indicated times after BMP-2 treatment was quantified by RT-PCR.
T11306	44734-44739	JJ	denotes	Total
T11307	44749-44752	NN	denotes	RNA
T11308	44740-44748	JJ	denotes	cellular
T11309	44757-44765	VBN	denotes	prepared
T11310	44753-44756	VBD	denotes	was
T11311	44766-44768	IN	denotes	as
T11312	44769-44778	VBN	denotes	described
T11313	44779-44784	RB	denotes	above
T11314	44784-44786	,	denotes	,
T11315	44786-44789	CC	denotes	and
T11316	44790-44801	NN	denotes	osteocalcin
T11317	44827-44837	NN	denotes	expression
T11318	44801-44803	,	denotes	,
T11319	44803-44804	NN	denotes	β
T11320	44805-44810	NN	denotes	actin
T11321	44804-44805	HYPH	denotes	-
T11322	44810-44812	,	denotes	,
T11323	44812-44815	CC	denotes	and
T11324	44816-44821	NN	denotes	GAPDH
T11325	44822-44826	NN	denotes	gene
T11326	44883-44893	VBN	denotes	quantified
T11327	44838-44840	IN	denotes	at
T11328	44841-44850	VBN	denotes	indicated
T11329	44851-44856	NNS	denotes	times
T11330	44857-44862	IN	denotes	after
T11331	44863-44866	NN	denotes	BMP
T11332	44869-44878	NN	denotes	treatment
T11333	44866-44867	HYPH	denotes	-
T11334	44867-44868	CD	denotes	2
T11335	44879-44882	VBD	denotes	was
T11336	44894-44896	IN	denotes	by
T11337	44897-44899	NN	denotes	RT
T11338	44900-44903	NN	denotes	PCR
T11339	44899-44900	HYPH	denotes	-
T11340	44903-44904	.	denotes	.
T10418	41373-41374	SYM	denotes	+
T8725	34991-35002	JJ	denotes	mesenchymal
R340	T1057	T1058	prep	During,favored
R341	T1059	T1060	amod	skeletal,development
R342	T1060	T1057	pobj	development,During
R343	T1061	T1058	punct	", ",favored
R344	T1062	T1063	det	the,activity
R345	T1063	T1058	nsubjpass	activity,favored
R346	T1064	T1063	amod	anabolic,activity
R347	T1065	T1063	prep	of,activity
R348	T1066	T1065	pobj	osteoblasts,of
R349	T1067	T1068	punct	[,1
R350	T1068	T1063	parataxis	1,activity
R351	T1069	T1068	punct	],1
R352	T1070	T1058	auxpass	is,favored
R353	T1071	T1058	prep	over,favored
R354	T1072	T1073	det	the,activity
R355	T1073	T1071	pobj	activity,over
R356	T1074	T1073	amod	catabolic,activity
R357	T1075	T1073	prep	of,activity
R358	T1076	T1075	pobj	osteoclasts,of
R359	T1077	T1078	punct	[,2
R360	T1078	T1073	appos	2,activity
R361	T1079	T1078	punct	],2
R362	T1080	T1073	punct	", ",activity
R363	T1081	T1082	dep	which,results
R364	T1082	T1073	relcl	results,activity
R365	T1083	T1082	prep	in,results
R366	T1084	T1085	det	a,gain
R367	T1085	T1083	pobj	gain,in
R368	T1086	T1085	amod	net,gain
R369	T1087	T1085	prep	in,gain
R370	T1088	T1089	compound	bone,mass
R371	T1089	T1087	pobj	mass,in
R372	T1090	T1058	punct	.,favored
R373	T1092	T1093	prep	At,maintained
R374	T1094	T1095	amod	skeletal,maturity
R375	T1095	T1092	pobj	maturity,At
R376	T1096	T1093	punct	", ",maintained
R377	T1097	T1098	compound	bone,mass
R378	T1098	T1093	nsubjpass	mass,maintained
R379	T1099	T1093	auxpass	is,maintained
R380	T1100	T1093	prep	through,maintained
R381	T1101	T1102	det	the,activity
R382	T1102	T1100	pobj	activity,through
R383	T1103	T1102	amod	balanced,activity
R384	T1104	T1102	prep	of,activity
R385	T1105	T1104	pobj	osteoblasts,of
R386	T1106	T1105	cc	and,osteoblasts
R387	T1107	T1105	conj	osteoclasts,osteoblasts
R388	T1108	T1093	prep	during,maintained
R389	T1109	T1110	det	the,cycle
R390	T1110	T1108	pobj	cycle,during
R391	T1111	T1110	compound	remodeling,cycle
R392	T1112	T1093	punct	.,maintained
R393	T1114	T1115	prep	During,is
R394	T1116	T1117	amod	skeletal,aging
R395	T1117	T1114	pobj	aging,During
R396	T1118	T1115	punct	", ",is
R397	T1119	T1115	expl	there,is
R398	T1120	T1121	det	a,shift
R399	T1121	T1115	attr	shift,is
R400	T1122	T1121	prep	in,shift
R401	T1123	T1124	det	the,balance
R402	T1124	T1122	pobj	balance,in
R403	T1125	T1126	dep	that,favors
R404	T1126	T1121	relcl	favors,shift
R405	T1127	T1126	dative	osteoclast,favors
R406	T1128	T1126	prep	over,favors
R407	T1129	T1128	pobj	osteoblast,over
R408	T1130	T1126	dobj	activity,favors
R409	T1131	T1126	punct	", ",favors
R410	T1132	T1133	dep	which,results
R411	T1133	T1126	ccomp	results,favors
R412	T1134	T1133	prep	in,results
R413	T1135	T1136	amod	net,loss
R414	T1136	T1134	pobj	loss,in
R415	T1137	T1136	compound	bone,loss
R416	T1138	T1139	punct	[,3
R417	T1139	T1115	parataxis	3,is
R418	T1140	T1139	punct	],3
R419	T1141	T1115	punct	.,is
R420	T1143	T1144	det	The,amount
R421	T1144	T1145	nsubjpass	amount,determined
R422	T1146	T1144	cc	and,amount
R423	T1147	T1144	conj	rate,amount
R424	T1148	T1149	prep	at,gained
R425	T1149	T1147	relcl	gained,rate
R426	T1150	T1148	pobj	which,at
R427	T1151	T1149	nsubjpass	bone,gained
R428	T1152	T1149	auxpass	is,gained
R429	T1153	T1149	prep	during,gained
R430	T1154	T1153	pobj	development,during
R431	T1155	T1149	cc	and,gained
R432	T1156	T1149	conj	lost,gained
R433	T1157	T1156	prep	during,lost
R434	T1158	T1157	pobj	aging,during
R435	T1159	T1145	auxpass	are,determined
R436	T1160	T1145	prep	in,determined
R437	T1161	T1162	amod	large,part
R438	T1162	T1160	pobj	part,in
R439	T1163	T1145	prep	by,determined
R440	T1164	T1163	pobj	genetics,by
R441	T1165	T1166	punct	[,4
R442	T1166	T1164	parataxis	4,genetics
R443	T1167	T1168	punct	–,6
R444	T1168	T1166	prep	6,4
R445	T1169	T1166	punct	],4
R446	T1170	T1163	cc	but,by
R447	T1171	T1170	advmod	also,but
R448	T1172	T1163	conj	by,by
R449	T1173	T1174	amod	physical,activity
R450	T1174	T1172	pobj	activity,by
R451	T1175	T1172	cc	and,by
R452	T1176	T1172	conj	by,by
R453	T1177	T1176	pobj	alterations,by
R454	T1178	T1177	prep	in,alterations
R455	T1179	T1180	det	the,availability
R456	T1180	T1178	pobj	availability,in
R457	T1181	T1180	cc	and,availability
R458	T1182	T1180	conj	response,availability
R459	T1183	T1180	prep	of,availability
R460	T1184	T1185	compound	bone,cells
R461	T1185	T1183	pobj	cells,of
R462	T1186	T1180	prep	to,availability
R463	T1187	T1188	amod	circulating,hormones
R464	T1188	T1186	pobj	hormones,to
R465	T1189	T1190	punct	[,7
R466	T1190	T1188	parataxis	7,hormones
R467	T1191	T1192	punct	–,9
R468	T1192	T1190	prep	9,7
R469	T1193	T1190	punct	],7
R470	T1194	T1188	cc	and,hormones
R471	T1195	T1196	advmod	locally,derived
R472	T1196	T1197	amod	derived,factors
R473	T1197	T1188	conj	factors,hormones
R474	T1198	T1197	compound	growth,factors
R475	T1199	T1200	punct	[,11
R476	T1200	T1197	parataxis	11,factors
R477	T1201	T1200	nummod	10,11
R478	T1202	T1200	punct	",",11
R479	T1203	T1200	punct	],11
R480	T1204	T1145	punct	.,determined
R481	T1206	T1207	mark	Whereas,provided
R482	T1207	T1213	advcl	provided,known
R483	T1208	T1209	amod	genetic,based
R484	T1209	T1211	amod	based,studies
R485	T1210	T1209	punct	-,based
R486	T1211	T1207	nsubj	studies,provided
R487	T1212	T1207	aux	have,provided
R488	T1214	T1215	amod	novel,insights
R489	T1215	T1207	dobj	insights,provided
R490	T1216	T1215	prep	into,insights
R491	T1217	T1218	det	the,pathways
R492	T1218	T1216	pobj	pathways,into
R493	T1219	T1220	dep	that,regulate
R494	T1220	T1218	relcl	regulate,pathways
R495	T1221	T1222	compound	bone,development
R496	T1222	T1220	dobj	development,regulate
R497	T1223	T1224	punct	[,12
R498	T1224	T1220	parataxis	12,regulate
R499	T1225	T1226	punct	–,14
R500	T1226	T1224	prep	14,12
R501	T1227	T1224	punct	],12
R502	T1228	T1213	punct	", ",known
R503	T1229	T1230	advmod	relatively,little
R504	T1230	T1213	nsubjpass	little,known
R505	T1231	T1213	auxpass	is,known
R506	T1232	T1213	prep	about,known
R507	T1233	T1234	det	the,etiology
R508	T1234	T1232	pobj	etiology,about
R509	T1235	T1234	prep	of,etiology
R510	T1236	T1237	npadvmod	age,related
R511	T1237	T1239	amod	related,loss
R512	T1238	T1237	punct	-,related
R513	T1239	T1235	pobj	loss,of
R514	T1240	T1239	compound	bone,loss
R515	T1241	T1213	punct	.,known
R516	T1243	T1244	amod	Increased,resorption
R517	T1244	T1246	nsubjpass	resorption,associated
R518	T1245	T1244	compound	bone,resorption
R519	T1247	T1244	prep	in,resorption
R520	T1248	T1249	amod	elderly,men
R521	T1249	T1247	pobj	men,in
R522	T1250	T1249	cc	and,men
R523	T1251	T1249	conj	women,men
R524	T1252	T1246	auxpass	is,associated
R525	T1253	T1246	prep	with,associated
R526	T1254	T1255	det	a,reduction
R527	T1255	T1253	pobj	reduction,with
R528	T1256	T1255	prep	in,reduction
R529	T1257	T1258	compound	bone,mass
R530	T1258	T1256	pobj	mass,in
R531	T1259	T1255	cc	and,reduction
R532	T1260	T1261	det	an,increase
R533	T1261	T1255	conj	increase,reduction
R534	T1262	T1261	prep	in,increase
R535	T1263	T1264	amod	circulating,levels
R536	T1264	T1262	pobj	levels,in
R537	T1265	T1264	prep	of,levels
R538	T1266	T1267	compound	bone,biomarkers
R539	T1267	T1265	pobj	biomarkers,of
R540	T1268	T1269	punct	[,15
R541	T1269	T1246	parataxis	15,associated
R542	T1270	T1269	punct	],15
R543	T1271	T1246	punct	.,associated
R544	T1273	T1274	det	These,changes
R545	T1274	T1275	nsubjpass	changes,attributed
R546	T1276	T1275	aux	have,attributed
R547	T1277	T1275	auxpass	been,attributed
R548	T1278	T1275	advmod	primarily,attributed
R549	T1279	T1275	prep	to,attributed
R550	T1280	T1281	amod	nutritional,deficits
R551	T1281	T1279	pobj	deficits,to
R552	T1282	T1281	acl	resulting,deficits
R553	T1283	T1282	prep	in,resulting
R554	T1284	T1283	pobj	alterations,in
R555	T1285	T1284	prep	in,alterations
R556	T1286	T1287	det	the,axis
R557	T1287	T1285	pobj	axis,in
R558	T1288	T1289	nmod	parathyroid,hormone
R559	T1289	T1287	nmod	hormone,axis
R560	T1290	T1289	punct	–,hormone
R561	T1291	T1292	compound	vitamin,D
R562	T1292	T1289	appos	D,hormone
R563	T1293	T1294	punct	[,16
R564	T1294	T1281	parataxis	16,deficits
R565	T1295	T1294	punct	],16
R566	T1296	T1279	punct	", ",to
R567	T1297	T1279	conj	to,to
R568	T1298	T1299	amod	gonadal,deficiency
R569	T1299	T1297	pobj	deficiency,to
R570	T1300	T1299	compound	hormone,deficiency
R571	T1301	T1302	punct	[,17
R572	T1302	T1299	parataxis	17,deficiency
R573	T1303	T1302	punct	],17
R574	T1304	T1297	punct	", ",to
R575	T1305	T1297	conj	to,to
R576	T1306	T1307	compound	leptin,levels
R577	T1307	T1305	pobj	levels,to
R578	T1308	T1307	cc	and,levels
R579	T1309	T1310	det	the,system
R580	T1310	T1307	conj	system,levels
R581	T1311	T1310	amod	sympathetic,system
R582	T1312	T1310	amod	nervous,system
R583	T1313	T1314	punct	[,8
R584	T1314	T1310	parataxis	8,system
R585	T1315	T1314	punct	",",8
R586	T1316	T1314	appos	18,8
R587	T1317	T1318	punct	–,20
R588	T1318	T1316	prep	20,18
R589	T1319	T1314	punct	],8
R590	T1320	T1305	punct	", ",to
R591	T1321	T1305	cc	and,to
R592	T1322	T1305	conj	to,to
R593	T1323	T1322	pobj	alterations,to
R594	T1324	T1323	prep	in,alterations
R595	T1325	T1326	compound	bone,cell
R596	T1326	T1327	compound	cell,apoptosis
R597	T1327	T1324	pobj	apoptosis,in
R598	T1328	T1329	punct	[,21
R599	T1329	T1323	parataxis	21,alterations
R600	T1330	T1329	punct	],21
R601	T1331	T1275	punct	.,attributed
R602	T1333	T1334	compound	Bone,loss
R603	T1334	T1335	nsubjpass	loss,attributed
R604	T1336	T1334	prep	in,loss
R605	T1337	T1338	det	the,elderly
R606	T1338	T1336	pobj	elderly,in
R607	T1339	T1335	aux	has,attributed
R608	T1340	T1335	advmod	also,attributed
R609	T1341	T1335	auxpass	been,attributed
R610	T1342	T1335	prep	to,attributed
R611	T1343	T1342	pobj	alterations,to
R612	T1344	T1343	prep	in,alterations
R613	T1345	T1346	det	the,response
R614	T1346	T1344	pobj	response,in
R615	T1347	T1346	prep	of,response
R616	T1348	T1349	nmod	bone,marrow
R617	T1349	T1350	nmod	marrow,cells
R618	T1350	T1347	pobj	cells,of
R619	T1351	T1350	amod	stromal,cells
R620	T1352	T1346	prep	to,response
R621	T1353	T1354	poss	their,microenvironment
R622	T1354	T1352	pobj	microenvironment,to
R623	T1355	T1356	dep	that,favors
R624	T1356	T1346	relcl	favors,response
R625	T1357	T1356	dobj	differentiation,favors
R626	T1358	T1357	prep	down,differentiation
R627	T1359	T1360	det	the,lineage
R628	T1360	T1358	pobj	lineage,down
R629	T1361	T1360	compound	adipocyte,lineage
R630	T1362	T1363	advmod	rather,than
R631	T1363	T1360	cc	than,lineage
R632	T1364	T1365	det	the,lineage
R633	T1365	T1360	conj	lineage,lineage
R634	T1366	T1365	compound	osteoblast,lineage
R635	T1367	T1368	punct	[,22
R636	T1368	T1335	parataxis	22,attributed
R637	T1369	T1368	punct	],22
R638	T1370	T1335	punct	.,attributed
R639	T1372	T1373	nsubjpass	Aging,associated
R640	T1374	T1373	aux	has,associated
R641	T1375	T1373	advmod	long,associated
R642	T1376	T1373	auxpass	been,associated
R643	T1377	T1373	prep	with,associated
R644	T1378	T1379	det	an,increase
R645	T1379	T1377	pobj	increase,with
R646	T1380	T1379	prep	in,increase
R647	T1381	T1382	compound	marrow,fat
R648	T1382	T1380	pobj	fat,in
R649	T1383	T1382	punct	", ",fat
R650	T1384	T1385	advmod	where,favored
R651	T1385	T1382	relcl	favored,fat
R652	T1386	T1387	det	the,generation
R653	T1387	T1385	nsubjpass	generation,favored
R654	T1388	T1387	prep	of,generation
R655	T1389	T1388	pobj	adipocytes,of
R656	T1390	T1385	auxpass	is,favored
R657	T1391	T1385	prep	over,favored
R658	T1392	T1391	pobj	osteoblasts,over
R659	T1393	T1394	punct	[,23
R660	T1394	T1373	parataxis	23,associated
R661	T1395	T1394	punct	],23
R662	T1396	T1373	punct	.,associated
R663	T1398	T1399	nsubjpass	Osteoblasts,derived
R664	T1400	T1398	cc	and,Osteoblasts
R665	T1401	T1398	conj	adipocytes,Osteoblasts
R666	T1402	T1399	auxpass	are,derived
R667	T1403	T1399	prep	from,derived
R668	T1404	T1405	det	a,cell
R669	T1405	T1403	pobj	cell,from
R670	T1406	T1405	amod	common,cell
R671	T1407	T1405	amod	mesenchymal,cell
R672	T1408	T1405	compound	precursor,cell
R673	T1409	T1405	relcl	present,cell
R674	T1410	T1409	prep	in,present
R675	T1411	T1412	compound	bone,marrow
R676	T1412	T1410	pobj	marrow,in
R677	T1413	T1399	punct	", ",derived
R678	T1414	T1399	cc	and,derived
R679	T1415	T1416	det	the,factors
R680	T1416	T1417	nsubjpass	factors,understood
R681	T1417	T1399	conj	understood,derived
R682	T1418	T1419	dep	that,control
R683	T1419	T1416	relcl	control,factors
R684	T1420	T1421	det	this,switch
R685	T1421	T1419	dobj	switch,control
R686	T1422	T1423	npadvmod	age,induced
R687	T1423	T1421	amod	induced,switch
R688	T1424	T1423	punct	-,induced
R689	T1425	T1421	prep	toward,switch
R690	T1426	T1427	amod	adipogenic,differentiation
R691	T1427	T1425	pobj	differentiation,toward
R692	T1428	T1417	auxpass	is,understood
R693	T1429	T1417	neg	not,understood
R694	T1430	T1417	advmod	well,understood
R695	T1431	T1432	punct	[,24
R696	T1432	T1417	parataxis	24,understood
R697	T1433	T1432	punct	],24
R698	T1434	T1417	punct	.,understood
R699	T1436	T1437	mark	While,associated
R700	T1437	T1444	advcl	associated,remains
R701	T1438	T1439	amod	several,proteins
R702	T1439	T1437	nsubjpass	proteins,associated
R703	T1440	T1439	amod	transcriptional,proteins
R704	T1441	T1439	amod	regulatory,proteins
R705	T1442	T1437	aux	have,associated
R706	T1443	T1437	auxpass	been,associated
R707	T1445	T1437	prep	with,associated
R708	T1446	T1447	compound	cell,determination
R709	T1447	T1445	pobj	determination,with
R710	T1448	T1447	compound	fate,determination
R711	T1449	T1447	prep	of,determination
R712	T1450	T1451	nmod	bone,marrow
R713	T1451	T1452	nmod	marrow,cells
R714	T1452	T1449	pobj	cells,of
R715	T1453	T1452	amod	mesenchymal,cells
R716	T1454	T1452	punct	", ",cells
R717	T1455	T1452	prep	including,cells
R718	T1456	T1457	nmod	peroxisome,receptor
R719	T1457	T1455	pobj	receptor,including
R720	T1458	T1459	npadvmod	proliferator,activated
R721	T1459	T1457	amod	activated,receptor
R722	T1460	T1459	punct	–,activated
R723	T1461	T1457	punct	γ,receptor
R724	T1462	T1457	punct	(,receptor
R725	T1463	T1457	appos	PPARγ,receptor
R726	T1464	T1457	punct	),receptor
R727	T1465	T1457	cc	and,receptor
R728	T1466	T1457	conj	KLF5,receptor
R729	T1467	T1468	punct	[,25
R730	T1468	T1437	parataxis	25,associated
R731	T1469	T1470	punct	–,30
R732	T1470	T1468	prep	30,25
R733	T1471	T1468	punct	],25
R734	T1472	T1444	punct	", ",remains
R735	T1473	T1474	det	the,role
R736	T1474	T1444	nsubj	role,remains
R737	T1475	T1474	prep	of,role
R738	T1476	T1477	compound	RNA,proteins
R739	T1477	T1475	pobj	proteins,of
R740	T1478	T1477	compound	binding,proteins
R741	T1479	T1474	prep	in,role
R742	T1480	T1481	det	this,process
R743	T1481	T1479	pobj	process,in
R744	T1482	T1444	acomp	unknown,remains
R745	T1483	T1444	punct	.,remains
R746	T1485	T1486	compound	RNA,proteins
R747	T1486	T1488	nsubj	proteins,are
R748	T1487	T1486	compound	binding,proteins
R749	T1489	T1486	prep	of,proteins
R750	T1490	T1491	det	the,type
R751	T1491	T1489	pobj	type,of
R752	T1492	T1491	compound	KH,type
R753	T1493	T1494	amod	known,regulators
R754	T1494	T1488	attr	regulators,are
R755	T1495	T1494	prep	of,regulators
R756	T1496	T1497	amod	cellular,differentiation
R757	T1497	T1495	pobj	differentiation,of
R758	T1498	T1488	punct	.,are
R759	T1500	T1501	prep	For,known
R760	T1502	T1500	pobj	example,For
R761	T1503	T1501	punct	", ",known
R762	T1504	T1505	compound	expression,defects
R763	T1505	T1501	nsubjpass	defects,known
R764	T1506	T1505	prep	in,defects
R765	T1507	T1508	det	the,proteins
R766	T1508	T1506	pobj	proteins,in
R767	T1509	T1510	compound	KH,domain
R768	T1510	T1508	compound	domain,proteins
R769	T1511	T1508	appos	NOVA,proteins
R770	T1512	T1511	cc	and,NOVA
R771	T1513	T1511	conj	FMRP,NOVA
R772	T1514	T1501	auxpass	are,known
R773	T1515	T1516	aux	to,cause
R774	T1516	T1501	xcomp	cause,known
R775	T1517	T1518	amod	paraneoplastic,disorders
R776	T1518	T1516	dobj	disorders,cause
R777	T1519	T1518	amod	neurologic,disorders
R778	T1520	T1521	punct	[,31
R779	T1521	T1518	parataxis	31,disorders
R780	T1522	T1521	punct	],31
R781	T1523	T1518	cc	and,disorders
R782	T1524	T1525	det	the,syndrome
R783	T1525	T1518	conj	syndrome,disorders
R784	T1526	T1527	amod	fragile,X
R785	T1527	T1525	compound	X,syndrome
R786	T1528	T1516	punct	", ",cause
R787	T1529	T1516	advmod	respectively,cause
R788	T1530	T1516	punct	", ",cause
R789	T1531	T1516	prep	in,cause
R790	T1532	T1531	pobj	humans,in
R791	T1533	T1534	punct	[,32
R792	T1534	T1516	parataxis	32,cause
R793	T1535	T1534	punct	],32
R794	T1536	T1501	punct	.,known
R795	T1538	T1539	det	The,phenotype
R796	T1539	T1540	nsubj	phenotype,suggests
R797	T1541	T1539	prep	of,phenotype
R798	T1542	T1543	det	the,mice
R799	T1543	T1541	pobj	mice,of
R800	T1544	T1543	nmod	quaking,mice
R801	T1545	T1543	amod	viable,mice
R802	T1546	T1547	det	a,role
R803	T1547	T1540	dobj	role,suggests
R804	T1548	T1547	prep	for,role
R805	T1549	T1550	det	the,protein
R806	T1550	T1548	pobj	protein,for
R807	T1551	T1550	compound	QUAKING,protein
R808	T1552	T1553	compound	RNA,binding
R809	T1553	T1550	compound	binding,protein
R810	T1554	T1547	prep	in,role
R811	T1555	T1554	pobj	oligodendrocytes,in
R812	T1556	T1555	cc	and,oligodendrocytes
R813	T1557	T1555	conj	myelination,oligodendrocytes
R814	T1558	T1559	punct	[,33
R815	T1559	T1540	parataxis	33,suggests
R816	T1560	T1559	punct	],33
R817	T1561	T1540	punct	.,suggests
R818	T1563	T1564	advmod	Indeed,led
R819	T1565	T1564	punct	", ",led
R820	T1566	T1567	det	the,expression
R821	T1567	T1564	nsubj	expression,led
R822	T1568	T1567	amod	ectopic,expression
R823	T1569	T1567	prep	of,expression
R824	T1570	T1571	det	the,isoforms
R825	T1571	T1569	pobj	isoforms,of
R826	T1572	T1573	nmod	QKI,7
R827	T1573	T1571	nummod	7,isoforms
R828	T1574	T1573	punct	-,7
R829	T1575	T1573	nummod	6,7
R830	T1576	T1573	punct	/,7
R831	T1577	T1578	advmod	in,vivo
R832	T1578	T1564	advmod	vivo,led
R833	T1579	T1564	prep	to,led
R834	T1580	T1581	det	the,formation
R835	T1581	T1579	pobj	formation,to
R836	T1582	T1581	prep	of,formation
R837	T1583	T1584	amod	glial,cells
R838	T1584	T1582	pobj	cells,of
R839	T1585	T1586	advmod	rather,than
R840	T1586	T1584	cc	than,cells
R841	T1587	T1584	conj	neurons,cells
R842	T1588	T1581	prep	from,formation
R843	T1589	T1590	amod	neural,progenitor
R844	T1590	T1588	pobj	progenitor,from
R845	T1591	T1564	punct	", ",led
R846	T1592	T1564	advcl	demonstrating,led
R847	T1593	T1594	poss	its,role
R848	T1594	T1592	dobj	role,demonstrating
R849	T1595	T1594	prep	in,role
R850	T1596	T1597	compound	cell,determination
R851	T1597	T1595	pobj	determination,in
R852	T1598	T1597	compound	fate,determination
R853	T1599	T1600	punct	[,34
R854	T1600	T1564	parataxis	34,led
R855	T1601	T1600	punct	],34
R856	T1602	T1564	punct	.,led
R857	T1604	T1605	det	The,loss
R858	T1605	T1606	nsubj	loss,prevents
R859	T1607	T1605	prep	of,loss
R860	T1608	T1609	nmod	GLD,protein
R861	T1609	T1607	pobj	protein,of
R862	T1610	T1608	punct	-,GLD
R863	T1611	T1608	nummod	1,GLD
R864	T1612	T1605	prep	in,loss
R865	T1613	T1614	compound	Caenorhabditis,elegans
R866	T1614	T1612	pobj	elegans,in
R867	T1615	T1616	det	the,appearance
R868	T1616	T1606	dobj	appearance,prevents
R869	T1617	T1616	prep	of,appearance
R870	T1618	T1619	compound	stem,cells
R871	T1619	T1617	pobj	cells,of
R872	T1620	T1621	punct	[,35
R873	T1621	T1606	parataxis	35,prevents
R874	T1622	T1621	punct	],35
R875	T1623	T1606	punct	", ",prevents
R876	T1624	T1606	cc	and,prevents
R877	T1625	T1626	det	the,absence
R878	T1626	T1627	nsubj	absence,prevents
R879	T1627	T1606	conj	prevents,prevents
R880	T1628	T1626	prep	of,absence
R881	T1629	T1630	det	the,protein
R882	T1630	T1628	pobj	protein,of
R883	T1631	T1630	compound	KH,protein
R884	T1632	T1630	compound	domain,protein
R885	T1633	T1630	appos	HOW,protein
R886	T1634	T1626	prep	in,absence
R887	T1635	T1634	pobj	Drosophila,in
R888	T1636	T1637	compound	muscle,differentiation
R889	T1637	T1627	dobj	differentiation,prevents
R890	T1638	T1627	cc	and,prevents
R891	T1639	T1627	conj	results,prevents
R892	T1640	T1639	prep	in,results
R893	T1641	T1640	pobj	flies,in
R894	T1642	T1641	prep	with,flies
R895	T1643	T1644	amod	held,wings
R896	T1644	T1642	pobj	wings,with
R897	T1645	T1643	punct	-,held
R898	T1646	T1643	prt	out,held
R899	T1647	T1644	punct	-,wings
R900	T1648	T1649	punct	[,37
R901	T1649	T1639	parataxis	37,results
R902	T1650	T1649	nummod	36,37
R903	T1651	T1649	punct	",",37
R904	T1652	T1649	punct	],37
R905	T1653	T1627	punct	.,prevents
R906	T1655	T1656	det	The,substrate
R907	T1656	T1658	nsubj	substrate,is
R908	T1657	T1656	compound	Src,substrate
R909	T1658	T1668	ccomp	is,remained
R910	T1659	T1656	acl	associated,substrate
R911	T1660	T1659	prep	in,associated
R912	T1661	T1660	pobj	mitosis,in
R913	T1662	T1661	prep	of,mitosis
R914	T1663	T1664	nummod	68,kDa
R915	T1664	T1662	pobj	kDa,of
R916	T1665	T1666	punct	(,Sam68
R917	T1666	T1659	parataxis	Sam68,associated
R918	T1667	T1666	punct	),Sam68
R919	T1669	T1658	advmod	also,is
R920	T1670	T1671	det	a,member
R921	T1671	T1658	attr	member,is
R922	T1672	T1671	prep	of,member
R923	T1673	T1674	det	the,family
R924	T1674	T1672	pobj	family,of
R925	T1675	T1674	prep	of,family
R926	T1676	T1677	compound	KH,proteins
R927	T1677	T1675	pobj	proteins,of
R928	T1678	T1677	compound	domain,proteins
R929	T1679	T1680	compound	RNA,binding
R930	T1680	T1677	compound	binding,proteins
R931	T1681	T1682	punct	[,38
R932	T1682	T1658	parataxis	38,is
R933	T1683	T1682	punct	],38
R934	T1684	T1668	punct	;,remained
R935	T1685	T1668	advmod	however,remained
R936	T1686	T1668	punct	", ",remained
R937	T1687	T1688	poss	its,role
R938	T1688	T1668	nsubj	role,remained
R939	T1689	T1688	amod	physiologic,role
R940	T1690	T1668	aux	has,remained
R941	T1691	T1668	acomp	undefined,remained
R942	T1692	T1668	punct	.,remained
R943	T1721	T1719	prep	42,39
R944	T1694	T1695	nsubjpass	Sam68,identified
R945	T1722	T1719	punct	],39
R946	T1723	T1715	cc	and,of
R947	T1724	T1715	conj	of,of
R948	T1725	T1726	det	the,kinase
R949	T1696	T1695	auxpass	was,identified
R950	T1726	T1724	pobj	kinase,of
R951	T1727	T1728	compound	breast,tumor
R952	T1728	T1726	compound	tumor,kinase
R953	T1729	T1730	punct	[,43
R954	T1697	T1695	prep	as,identified
R955	T1730	T1726	parataxis	43,kinase
R956	T1731	T1730	punct	],43
R957	T1698	T1699	det	an,protein
R958	T1732	T1695	punct	.,identified
R959	T1734	T1735	nsubjpass	Sam68,shown
R960	T1736	T1735	aux	has,shown
R961	T1737	T1735	auxpass	been,shown
R962	T1699	T1697	pobj	protein,as
R963	T1738	T1739	aux	to,facilitate
R964	T1700	T1699	nmod	SH3,protein
R965	T1739	T1735	xcomp	facilitate,shown
R966	T1701	T1700	cc	and,SH3
R967	T1702	T1700	conj	SH2,SH3
R968	T1740	T1741	det	the,export
R969	T1703	T1699	nmod	domain,protein
R970	T1741	T1739	dobj	export,facilitate
R971	T1704	T1699	amod	interacting,protein
R972	T1742	T1741	prep	of,export
R973	T1743	T1744	amod	unspliced,RNA
R974	T1744	T1742	pobj	RNA,of
R975	T1705	T1695	prep	for,identified
R976	T1745	T1744	compound	HIV,RNA
R977	T1746	T1747	punct	[,44
R978	T1747	T1739	parataxis	44,facilitate
R979	T1706	T1707	compound	Src,kinases
R980	T1748	T1747	punct	],44
R981	T1749	T1739	cc	and,facilitate
R982	T1750	T1751	aux	to,regulate
R983	T1707	T1705	pobj	kinases,for
R984	T1751	T1739	conj	regulate,facilitate
R985	T1752	T1753	compound	pre-mRNA,processing
R986	T1708	T1707	compound	family,kinases
R987	T1753	T1751	dobj	processing,regulate
R988	T1754	T1755	punct	[,45
R989	T1755	T1751	parataxis	45,regulate
R990	T1709	T1695	cc	and,identified
R991	T1756	T1755	punct	],45
R992	T1757	T1735	punct	.,shown
R993	T1759	T1760	prep	In,report
R994	T1710	T1695	conj	is,identified
R995	T1761	T1762	det	the,paper
R996	T1711	T1710	advmod	also,is
R997	T1762	T1759	pobj	paper,In
R998	T1763	T1762	amod	present,paper
R999	T1764	T1760	punct	", ",report
R1000	T1712	T1713	det	a,substrate
R1001	T1765	T1760	nsubj	we,report
R1002	T1766	T1767	det	the,generation
R1003	T1767	T1760	dobj	generation,report
R1004	T1768	T1767	prep	of,generation
R1005	T1713	T1710	attr	substrate,is
R1006	T1769	T1770	nmod	Sam68,mice
R1007	T1770	T1768	pobj	mice,of
R1008	T1714	T1713	amod	known,substrate
R1009	T1771	T1769	punct	−,Sam68
R1010	T1772	T1769	punct	/,Sam68
R1011	T1773	T1769	punct	−,Sam68
R1012	T1774	T1767	cc	and,generation
R1013	T1775	T1767	conj	analysis,generation
R1014	T1776	T1775	prep	of,analysis
R1015	T1777	T1778	poss	their,phenotype
R1016	T1715	T1713	prep	of,substrate
R1017	T1778	T1776	pobj	phenotype,of
R1018	T1779	T1778	amod	skeletal,phenotype
R1019	T1780	T1760	punct	.,report
R1020	T1716	T1717	compound	Src,kinases
R1021	T1782	T1783	poss	Our,data
R1022	T1717	T1715	pobj	kinases,of
R1023	T1783	T1784	nsubj	data,indicate
R1024	T1785	T1786	mark	that,confers
R1025	T1718	T1719	punct	[,39
R1026	T1786	T1784	ccomp	confers,indicate
R1027	T1787	T1788	det	the,absence
R1028	T1719	T1717	parataxis	39,kinases
R1029	T1788	T1786	nsubj	absence,confers
R1030	T1789	T1788	prep	of,absence
R1031	T1790	T1789	pobj	Sam68,of
R1032	T1720	T1721	punct	–,42
R1033	T1791	T1786	dobj	resistance,confers
R1034	T1792	T1791	prep	to,resistance
R1035	T1793	T1794	npadvmod	age,related
R1036	T1826	T1827	nmod	bone,marrow
R1037	T1794	T1796	amod	related,loss
R1038	T1795	T1794	punct	-,related
R1039	T1796	T1792	pobj	loss,to
R1040	T1797	T1796	compound	bone,loss
R1041	T1798	T1786	prep	in,confers
R1042	T1799	T1798	pobj	mice,in
R1043	T1827	T1828	nmod	marrow,cells
R1044	T1800	T1801	amod	such,have
R1045	T1801	T1786	advcl	have,confers
R1046	T1802	T1801	mark	that,have
R1047	T1828	T1825	pobj	cells,of
R1048	T1803	T1804	amod	old,Sam68
R1049	T1804	T1801	nsubj	Sam68,have
R1050	T1805	T1806	det	a,mass
R1051	T1829	T1828	amod	stromal,cells
R1052	T1806	T1801	dobj	mass,have
R1053	T1807	T1806	amod	higher,mass
R1054	T1808	T1806	compound	bone,mass
R1055	T1830	T1818	prep	by,provide
R1056	T1809	T1806	prep	than,mass
R1057	T1810	T1811	poss	their,littermates
R1058	T1811	T1809	pobj	littermates,than
R1059	T1831	T1830	pcomp	showing,by
R1060	T1812	T1813	amod	wild,type
R1061	T1813	T1811	compound	type,littermates
R1062	T1814	T1813	punct	-,type
R1063	T1815	T1784	punct	.,indicate
R1064	T1817	T1818	nsubj	We,provide
R1065	T1832	T1833	mark	that,had
R1066	T1819	T1818	dobj	evidence,provide
R1067	T1820	T1821	mark	that,regulates
R1068	T1833	T1831	ccomp	had,showing
R1069	T1821	T1819	acl	regulates,evidence
R1070	T1822	T1821	nsubj	Sam68,regulates
R1071	T1823	T1824	det	the,differentiation
R1072	T1834	T1833	nsubj	cells,had
R1073	T1824	T1821	dobj	differentiation,regulates
R1074	T1825	T1824	prep	of,differentiation
R1075	T1835	T1834	acl	isolated,cells
R1076	T1836	T1835	prep	from,isolated
R1077	T1837	T1838	nmod	Sam68,animals
R1078	T1838	T1836	pobj	animals,from
R1079	T1839	T1837	punct	−,Sam68
R1080	T1840	T1837	punct	/,Sam68
R1081	T1841	T1837	punct	−,Sam68
R1082	T1842	T1843	amod	enhanced,activity
R1083	T1843	T1833	dobj	activity,had
R1084	T1844	T1843	amod	osteogenic,activity
R1085	T1845	T1843	cc	and,activity
R1086	T1846	T1847	amod	decreased,activity
R1087	T1847	T1843	conj	activity,activity
R1088	T1848	T1847	amod	adipogenic,activity
R1089	T1849	T1843	prep	than,activity
R1090	T1850	T1849	pobj	those,than
R1091	T1851	T1850	acl	harvested,those
R1092	T1852	T1851	prep	from,harvested
R1093	T1853	T1854	amod	wild,type
R1094	T1854	T1856	compound	type,littermates
R1095	T1855	T1854	punct	-,type
R1096	T1856	T1852	pobj	littermates,from
R1097	T1857	T1818	punct	.,provide
R1098	T1859	T1860	advmod	Furthermore,impaired
R1099	T1861	T1860	punct	", ",impaired
R1100	T1862	T1860	nsubjpass	Sam68,impaired
R1101	T1863	T1862	punct	−,Sam68
R1102	T1864	T1862	punct	/,Sam68
R1103	T1865	T1862	punct	−,Sam68
R1104	T1866	T1867	compound	mouse,embryo
R1105	T1867	T1868	compound	embryo,fibroblasts
R1106	T1868	T1862	appos	fibroblasts,Sam68
R1107	T1869	T1868	punct	(,fibroblasts
R1108	T1870	T1868	appos	MEFs,fibroblasts
R1109	T1871	T1862	punct	),Sam68
R1110	T1872	T1860	auxpass	were,impaired
R1111	T1873	T1860	prep	in,impaired
R1112	T1874	T1875	poss	their,capacity
R1113	T1875	T1873	pobj	capacity,in
R1114	T1876	T1877	aux	to,differentiate
R1115	T1877	T1875	acl	differentiate,capacity
R1116	T1878	T1877	prep	into,differentiate
R1117	T1879	T1878	pobj	adipocytes,into
R1118	T1880	T1860	punct	", ",impaired
R1119	T1881	T1860	advcl	consistent,impaired
R1120	T1882	T1881	prep	with,consistent
R1121	T1883	T1884	nsubj	Sam68,being
R1122	T1884	T1882	pcomp	being,with
R1123	T1885	T1886	det	a,regulator
R1124	T1886	T1884	attr	regulator,being
R1125	T1887	T1886	prep	of,regulator
R1126	T1888	T1889	nmod	bone,marrow
R1127	T1889	T1890	nmod	marrow,differentiation
R1128	T1890	T1887	pobj	differentiation,of
R1129	T1891	T1890	amod	mesenchymal,differentiation
R1130	T1892	T1890	compound	cell,differentiation
R1131	T1893	T1860	punct	.,impaired
R1132	T1895	T1896	det	These,results
R1133	T1896	T1897	nsubj	results,characterize
R1134	T1898	T1897	advmod	also,characterize
R1135	T1899	T1900	det	a,model
R1136	T1900	T1897	dobj	model,characterize
R1137	T1901	T1900	amod	new,model
R1138	T1902	T1900	compound	animal,model
R1139	T1903	T1904	aux	to,study
R1140	T1904	T1900	advcl	study,model
R1141	T1905	T1906	compound	bone,metabolism
R1142	T1906	T1904	dobj	metabolism,study
R1143	T1907	T1906	punct	", ",metabolism
R1144	T1908	T1906	conj	regeneration,metabolism
R1145	T1909	T1908	punct	", ",regeneration
R1146	T1910	T1908	cc	and,regeneration
R1147	T1911	T1908	conj	repair,regeneration
R1148	T1912	T1904	prep	during,study
R1149	T1913	T1912	pobj	aging,during
R1150	T1914	T1897	punct	.,characterize
R1155	T2061	T2062	nsubjpass	Sam68,Expressed
R1156	T2063	T2062	auxpass	Is,Expressed
R1157	T2064	T2062	prep	in,Expressed
R1158	T2065	T2066	det	the,Skeleton
R1159	T2066	T2064	pobj	Skeleton,in
R1160	T2067	T2066	amod	Developing,Skeleton
R1161	T2068	T2066	prep	of,Skeleton
R1162	T2069	T2070	amod	Embryonic,Mice
R1163	T2070	T2068	pobj	Mice,of
R1164	T2072	T2073	det	The,mRNA
R1165	T2073	T2075	nsubjpass	mRNA,known
R1166	T2074	T2073	compound	Sam68,mRNA
R1167	T2076	T2075	auxpass	is,known
R1168	T2077	T2078	aux	to,expressed
R1169	T2078	T2075	xcomp	expressed,known
R1170	T2079	T2078	auxpass	be,expressed
R1171	T2080	T2078	advmod	widely,expressed
R1172	T2081	T2082	punct	[,38
R1173	T2082	T2078	parataxis	38,expressed
R1174	T2083	T2082	punct	],38
R1175	T2084	T2078	punct	", ",expressed
R1176	T2085	T2086	mark	whereas,remains
R1177	T2086	T2078	advcl	remains,expressed
R1178	T2087	T2088	poss	its,pattern
R1179	T2088	T2086	nsubj	pattern,remains
R1180	T2089	T2088	prep	of,pattern
R1181	T2090	T2091	compound	protein,expression
R1182	T2091	T2089	pobj	expression,of
R1183	T2092	T2093	advmod	in,vivo
R1184	T2093	T2088	advmod	vivo,pattern
R1185	T2094	T2095	aux	to,defined
R1186	T2095	T2086	xcomp	defined,remains
R1187	T2096	T2095	auxpass	be,defined
R1188	T2097	T2075	punct	.,known
R1189	T2099	T2100	nsubjpass	Sections,immunostained
R1190	T2101	T2099	prep	of,Sections
R1191	T2102	T2103	npadvmod	paraffin,embedded
R1192	T2103	T2105	amod	embedded,mice
R1193	T2104	T2103	punct	-,embedded
R1194	T2105	T2101	pobj	mice,of
R1195	T2106	T2107	amod	wild,type
R1196	T2107	T2105	nmod	type,mice
R1197	T2108	T2107	punct	-,type
R1198	T2109	T2105	nmod	E14.5,mice
R1199	T2110	T2109	cc	and,E14.5
R1200	T2111	T2109	conj	E16.5,E14.5
R1201	T2112	T2105	amod	embryonic,mice
R1202	T2113	T2100	auxpass	were,immunostained
R1203	T2114	T2100	prep	with,immunostained
R1204	T2115	T2116	det	the,antibody
R1205	T2116	T2114	pobj	antibody,with
R1206	T2117	T2118	advmod	well,characterized
R1207	T2118	T2116	amod	characterized,antibody
R1208	T2119	T2118	punct	-,characterized
R1209	T2120	T2116	nmod	AD1,antibody
R1210	T2121	T2116	amod	anti-Sam68,antibody
R1211	T2122	T2116	punct	", ",antibody
R1212	T2123	T2116	acl	raised,antibody
R1213	T2124	T2123	prep	in,raised
R1214	T2125	T2124	pobj	rabbits,in
R1215	T2126	T2116	prep	against,antibody
R1216	T2127	T2128	det	an,peptide
R1217	T2128	T2126	pobj	peptide,against
R1218	T2129	T2128	amod	immunizing,peptide
R1219	T2130	T2131	dep	that,corresponds
R1220	T2131	T2128	relcl	corresponds,peptide
R1221	T2132	T2131	prep	to,corresponds
R1222	T2133	T2134	nmod	amino,330
R1223	T2134	T2132	pobj	330,to
R1224	T2135	T2134	nmod	acids,330
R1225	T2136	T2134	prep	to,330
R1226	T2137	T2136	pobj	348,to
R1227	T2138	T2134	prep	of,330
R1228	T2139	T2140	det	the,protein
R1229	T2140	T2138	pobj	protein,of
R1230	T2141	T2140	compound	mouse,protein
R1231	T2142	T2140	compound	Sam68,protein
R1232	T2143	T2144	punct	[,46
R1233	T2144	T2100	parataxis	46,immunostained
R1234	T2145	T2144	punct	],46
R1235	T2146	T2100	punct	.,immunostained
R1236	T2148	T2149	compound	Sam68,immunoreactivity
R1237	T2149	T2150	nsubjpass	immunoreactivity,observed
R1238	T2151	T2150	auxpass	was,observed
R1239	T2152	T2150	prep	in,observed
R1240	T2153	T2154	det	the,skeleton
R1241	T2154	T2152	pobj	skeleton,in
R1242	T2155	T2154	cc	and,skeleton
R1243	T2156	T2157	amod	soft,tissues
R1244	T2157	T2154	conj	tissues,skeleton
R1245	T2158	T2154	prep	of,skeleton
R1246	T2159	T2160	amod	developing,mice
R1247	T2160	T2158	pobj	mice,of
R1248	T2161	T2162	amod	wild,type
R1249	T2162	T2160	compound	type,mice
R1250	T2163	T2162	punct	-,type
R1251	T2164	T2150	prep	at,observed
R1252	T2165	T2164	pobj	E14.5,at
R1253	T2166	T2165	cc	and,E14.5
R1254	T2167	T2165	conj	E16.5,E14.5
R1255	T2168	T2169	punct	(,Figure
R1256	T2169	T2150	parataxis	Figure,observed
R1257	T2170	T2169	nummod	1,Figure
R1258	T2171	T2169	punct	),Figure
R1259	T2172	T2150	punct	.,observed
R1260	T2174	T2175	amod	Intense,staining
R1261	T2175	T2176	nsubjpass	staining,seen
R1262	T2177	T2176	auxpass	was,seen
R1263	T2178	T2176	prep	in,seen
R1264	T2179	T2180	det	the,nucleus
R1265	T2180	T2178	pobj	nucleus,in
R1266	T2181	T2180	prep	of,nucleus
R1267	T2182	T2181	pobj	cells,of
R1268	T2183	T2176	prep	in,seen
R1269	T2184	T2185	det	the,brain
R1270	T2185	T2183	pobj	brain,in
R1271	T2186	T2185	amod	developing,brain
R1272	T2187	T2185	punct	", ",brain
R1273	T2188	T2185	conj	heart,brain
R1274	T2189	T2188	punct	", ",heart
R1275	T2190	T2188	cc	and,heart
R1276	T2191	T2192	amod	small,intestine
R1277	T2192	T2188	conj	intestine,heart
R1278	T2193	T2194	punct	(,1B
R1279	T2194	T2185	parataxis	1B,brain
R1280	T2195	T2194	compound	Figure,1B
R1281	T2196	T2194	punct	),1B
R1282	T2197	T2183	punct	", ",in
R1283	T2198	T2199	advmod	as,as
R1284	T2199	T2183	cc	as,in
R1285	T2200	T2199	advmod	well,as
R1286	T2201	T2183	conj	in,in
R1287	T2202	T2201	pobj	chondrocytes,in
R1288	T2203	T2202	prep	in,chondrocytes
R1289	T2204	T2205	det	the,septum
R1290	T2205	T2203	pobj	septum,in
R1291	T2206	T2205	amod	nasal,septum
R1292	T2207	T2205	cc	and,septum
R1293	T2208	T2209	det	the,tissue
R1294	T2209	T2205	conj	tissue,septum
R1295	T2210	T2209	amod	glandular,tissue
R1296	T2211	T2209	amod	adjacent,tissue
R1297	T2212	T2211	prep	to,adjacent
R1298	T2213	T2214	det	the,cartilage
R1299	T2214	T2212	pobj	cartilage,to
R1300	T2215	T2214	amod	nasal,cartilage
R1301	T2216	T2217	punct	(,1C
R1302	T2217	T2202	parataxis	1C,chondrocytes
R1303	T2218	T2217	compound	Figure,1C
R1304	T2219	T2217	punct	", ",1C
R1305	T2220	T2221	compound	panels,A
R1306	T2221	T2217	appos	A,1C
R1307	T2222	T2223	punct	–,D
R1308	T2223	T2221	prep	D,A
R1309	T2224	T2217	punct	),1C
R1310	T2225	T2201	punct	", ",in
R1311	T2226	T2201	prep	in,in
R1312	T2227	T2228	det	the,vertebra
R1313	T2228	T2226	pobj	vertebra,in
R1314	T2229	T2228	cc	and,vertebra
R1315	T2230	T2231	amod	intervertebral,discs
R1316	T2231	T2228	conj	discs,vertebra
R1317	T2232	T2233	punct	(,E
R1318	T2233	T2228	parataxis	E,vertebra
R1319	T2234	T2233	compound	panels,E
R1320	T2235	T2236	punct	–,H
R1321	T2236	T2233	prep	H,E
R1322	T2237	T2233	punct	),E
R1323	T2238	T2226	cc	and,in
R1324	T2239	T2226	conj	in,in
R1325	T2240	T2241	det	the,epiphysis
R1326	T2241	T2239	pobj	epiphysis,in
R1327	T2242	T2243	punct	(,I
R1328	T2243	T2241	parataxis	I,epiphysis
R1329	T2244	T2243	compound	panels,I
R1330	T2245	T2246	punct	–,K
R1331	T2246	T2243	prep	K,I
R1332	T2247	T2243	punct	),I
R1333	T2248	T2241	cc	and,epiphysis
R1334	T2249	T2241	conj	metaphysis,epiphysis
R1335	T2250	T2251	punct	(,L
R1336	T2251	T2249	parataxis	L,metaphysis
R1337	T2252	T2251	compound	panel,L
R1338	T2253	T2251	punct	),L
R1339	T2254	T2241	prep	of,epiphysis
R1340	T2255	T2256	amod	long,bones
R1341	T2256	T2254	pobj	bones,of
R1342	T2257	T2176	punct	.,seen
R1343	T2259	T2260	amod	Nuclear,staining
R1344	T2260	T2261	nsubjpass	staining,observed
R1345	T2262	T2261	auxpass	was,observed
R1346	T2263	T2261	prep	in,observed
R1347	T2264	T2265	amod	proliferating,chondrocytes
R1348	T2265	T2263	pobj	chondrocytes,in
R1349	T2266	T2265	cc	and,chondrocytes
R1350	T2267	T2268	amod	hypertrophic,chondrocytes
R1351	T2268	T2265	conj	chondrocytes,chondrocytes
R1352	T2269	T2270	punct	(,1C
R1353	T2270	T2268	parataxis	1C,chondrocytes
R1354	T2271	T2270	compound	Figure,1C
R1355	T2272	T2270	punct	", ",1C
R1356	T2273	T2274	compound	panel,H
R1357	T2274	T2270	appos	H,1C
R1358	T2275	T2270	punct	),1C
R1359	T2276	T2263	punct	", ",in
R1360	T2277	T2263	conj	in,in
R1361	T2278	T2277	pobj	osteoblasts,in
R1362	T2279	T2280	punct	(,L
R1363	T2280	T2278	parataxis	L,osteoblasts
R1364	T2281	T2280	compound	panel,L
R1365	T2282	T2280	punct	;,L
R1366	T2283	T2284	compound	Dataset,S1
R1367	T2284	T2280	appos	S1,L
R1368	T2285	T2280	punct	),L
R1369	T2286	T2277	punct	", ",in
R1370	T2287	T2277	cc	and,in
R1371	T2288	T2277	conj	in,in
R1372	T2289	T2288	pobj	osteoclasts,in
R1373	T2290	T2291	punct	(,S1
R1374	T2291	T2289	parataxis	S1,osteoclasts
R1375	T2292	T2291	compound	Dataset,S1
R1376	T2293	T2291	punct	),S1
R1377	T2294	T2261	punct	.,observed
R1378	T2296	T2297	det	No,staining
R1379	T2297	T2298	nsubjpass	staining,observed
R1380	T2299	T2298	auxpass	was,observed
R1381	T2300	T2298	prep	with,observed
R1382	T2301	T2302	amod	preimmune,serum
R1383	T2302	T2300	pobj	serum,with
R1384	T2303	T2300	cc	or,with
R1385	T2304	T2305	advmod	when,preadsorbed
R1386	T2305	T2300	conj	preadsorbed,with
R1387	T2306	T2307	det	the,antiserum
R1388	T2307	T2305	nsubjpass	antiserum,preadsorbed
R1389	T2308	T2305	auxpass	was,preadsorbed
R1390	T2309	T2305	prep	with,preadsorbed
R1391	T2310	T2311	det	the,peptide
R1392	T2311	T2309	pobj	peptide,with
R1393	T2312	T2311	amod	immunizing,peptide
R1394	T2313	T2314	punct	(,1C
R1395	T2314	T2305	parataxis	1C,preadsorbed
R1396	T2315	T2314	compound	Figure,1C
R1397	T2316	T2314	punct	", ",1C
R1398	T2317	T2318	compound	panels,B
R1399	T2318	T2314	appos	B,1C
R1400	T2319	T2318	punct	", ",B
R1401	T2320	T2318	conj	F,B
R1402	T2321	T2320	punct	", ",F
R1403	T2322	T2320	cc	and,F
R1404	T2323	T2320	conj	J,F
R1405	T2324	T2314	punct	),1C
R1406	T2325	T2298	punct	.,observed
R1407	T2327	T2328	advcl	Taken,demonstrate
R1408	T2329	T2327	advmod	together,Taken
R1409	T2330	T2328	punct	", ",demonstrate
R1410	T2331	T2332	det	these,data
R1411	T2332	T2328	nsubj	data,demonstrate
R1412	T2333	T2334	mark	that,expressed
R1413	T2334	T2328	ccomp	expressed,demonstrate
R1414	T2335	T2336	compound	Sam68,protein
R1415	T2336	T2334	nsubjpass	protein,expressed
R1416	T2337	T2334	auxpass	is,expressed
R1417	T2338	T2334	advmod	selectively,expressed
R1418	T2339	T2334	prep	in,expressed
R1419	T2340	T2341	det	the,embryo
R1420	T2341	T2339	pobj	embryo,in
R1421	T2342	T2341	amod	developing,embryo
R1422	T2343	T2341	compound	mouse,embryo
R1423	T2344	T2334	punct	", ",expressed
R1424	T2345	T2334	prep	with,expressed
R1425	T2346	T2347	advmod	particularly,elevated
R1426	T2347	T2348	amod	elevated,expression
R1427	T2348	T2345	pobj	expression,with
R1428	T2349	T2348	prep	in,expression
R1429	T2350	T2349	pobj	cartilage,in
R1430	T2351	T2350	cc	and,cartilage
R1431	T2352	T2350	conj	bone,cartilage
R1432	T2353	T2328	punct	.,demonstrate
R1433	T2520	T2521	nsubj	Sam68,is
R1434	T2522	T2521	neg	Not,is
R1435	T2523	T2521	acomp	Essential,is
R1436	T2524	T2523	prep	for,Essential
R1437	T2525	T2526	compound	Mouse,Development
R1438	T2526	T2524	pobj	Development,for
R1439	T2528	T2529	aux	To,define
R1440	T2529	T2530	advcl	define,generated
R1441	T2531	T2532	det	the,role
R1442	T2532	T2529	dobj	role,define
R1443	T2533	T2532	amod	physiologic,role
R1444	T2534	T2532	prep	of,role
R1445	T2535	T2534	pobj	Sam68,of
R1446	T2536	T2530	punct	", ",generated
R1447	T2537	T2530	nsubj	we,generated
R1448	T2538	T2539	npadvmod	Sam68,deficient
R1449	T2539	T2541	amod	deficient,mice
R1450	T2540	T2539	punct	-,deficient
R1451	T2541	T2530	dobj	mice,generated
R1452	T2542	T2530	prep	by,generated
R1453	T2543	T2544	amod	targeted,disruption
R1454	T2544	T2542	pobj	disruption,by
R1455	T2545	T2544	prep	of,disruption
R1456	T2546	T2547	nmod	exons,4
R1457	T2547	T2545	pobj	4,of
R1458	T2548	T2547	cc	and,4
R1459	T2549	T2547	conj	5,4
R1460	T2550	T2547	prep	of,4
R1461	T2551	T2552	det	the,gene
R1462	T2552	T2550	pobj	gene,of
R1463	T2553	T2552	compound	sam68,gene
R1464	T2554	T2547	punct	", ",4
R1465	T2555	T2556	dep	which,encode
R1466	T2556	T2547	relcl	encode,4
R1467	T2557	T2558	det	the,region
R1468	T2558	T2556	dobj	region,encode
R1469	T2559	T2558	amod	functional,region
R1470	T2560	T2558	prep	of,region
R1471	T2561	T2562	det	the,domain
R1472	T2562	T2560	pobj	domain,of
R1473	T2563	T2564	compound	KH,type
R1474	T2564	T2562	compound	type,domain
R1475	T2565	T2564	punct	-,type
R1476	T2566	T2567	compound	RNA,binding
R1477	T2567	T2562	compound	binding,domain
R1478	T2568	T2569	punct	(,2A
R1479	T2569	T2530	parataxis	2A,generated
R1480	T2570	T2569	compound	Figure,2A
R1481	T2571	T2569	punct	),2A
R1482	T2572	T2530	punct	.,generated
R1483	T2574	T2575	det	The,integrity
R1484	T2575	T2576	nsubjpass	integrity,verified
R1485	T2577	T2575	prep	of,integrity
R1486	T2578	T2579	det	the,allele
R1487	T2579	T2577	pobj	allele,of
R1488	T2580	T2579	amod	targeted,allele
R1489	T2581	T2576	auxpass	was,verified
R1490	T2582	T2576	prep	by,verified
R1491	T2583	T2584	compound	Southern,blot
R1492	T2584	T2585	compound	blot,analysis
R1493	T2585	T2582	pobj	analysis,by
R1494	T2586	T2587	punct	(,2B
R1495	T2587	T2585	parataxis	2B,analysis
R1496	T2588	T2587	compound	Figure,2B
R1497	T2589	T2587	punct	),2B
R1498	T2590	T2582	cc	and,by
R1499	T2591	T2582	conj	by,by
R1500	T2592	T2591	pobj	PCR,by
R1501	T2593	T2592	prep	of,PCR
R1502	T2594	T2595	amod	genomic,DNA
R1503	T2595	T2593	pobj	DNA,of
R1504	T2596	T2597	punct	(,data
R1505	T2597	T2592	meta	data,PCR
R1506	T2598	T2597	amod	unpublished,data
R1507	T2599	T2597	punct	),data
R1508	T2600	T2576	punct	.,verified
R1509	T2602	T2603	compound	Sam68,transcripts
R1510	T2603	T2604	nsubj	transcripts,were
R1511	T2605	T2603	acl	encoded,transcripts
R1512	T2606	T2605	agent	by,encoded
R1513	T2607	T2608	nmod	exons,1
R1514	T2608	T2606	pobj	1,by
R1515	T2609	T2608	prep	to,1
R1516	T2610	T2609	pobj	5,to
R1517	T2611	T2604	acomp	absent,were
R1518	T2612	T2613	mark	as,evidenced
R1519	T2613	T2604	advcl	evidenced,were
R1520	T2614	T2613	prep	by,evidenced
R1521	T2615	T2616	compound	RT,PCR
R1522	T2616	T2614	pobj	PCR,by
R1523	T2617	T2616	punct	-,PCR
R1524	T2618	T2619	punct	(,S2
R1525	T2619	T2613	parataxis	S2,evidenced
R1526	T2620	T2619	compound	Dataset,S2
R1527	T2621	T2619	punct	),S2
R1528	T2622	T2604	punct	", ",were
R1529	T2623	T2604	cc	and,were
R1530	T2624	T2625	nmod	Sam68,mice
R1531	T2625	T2629	nsubj	mice,were
R1532	T2626	T2624	punct	−,Sam68
R1533	T2627	T2624	punct	/,Sam68
R1534	T2628	T2624	punct	−,Sam68
R1535	T2629	T2604	conj	were,were
R1536	T2630	T2629	acomp	devoid,were
R1537	T2631	T2630	prep	of,devoid
R1538	T2632	T2633	compound	Sam68,protein
R1539	T2633	T2631	pobj	protein,of
R1540	T2634	T2629	punct	", ",were
R1541	T2635	T2636	mark	as,visualized
R1542	T2636	T2629	advcl	visualized,were
R1543	T2637	T2636	prep	by,visualized
R1544	T2638	T2637	pcomp	immunoblotting,by
R1545	T2639	T2638	prep	with,immunoblotting
R1546	T2640	T2641	amod	anti-Sam68,AD1
R1547	T2641	T2642	nmod	AD1,antibodies
R1548	T2642	T2639	pobj	antibodies,with
R1549	T2643	T2641	cc	and,AD1
R1550	T2644	T2641	conj	SC,AD1
R1551	T2645	T2644	punct	-,SC
R1552	T2646	T2644	nummod	333,SC
R1553	T2647	T2642	cc	or,antibodies
R1554	T2648	T2649	nmod	control,serum
R1555	T2649	T2642	conj	serum,antibodies
R1556	T2650	T2649	amod	normal,serum
R1557	T2651	T2649	compound	rabbit,serum
R1558	T2652	T2649	cc	or,serum
R1559	T2653	T2654	amod	anti-Sam68,AD1
R1560	T2654	T2649	conj	AD1,serum
R1561	T2655	T2654	acl	preabsorbed,AD1
R1562	T2656	T2655	prep	with,preabsorbed
R1563	T2657	T2656	pobj	peptide,with
R1564	T2658	T2659	punct	(,2C
R1565	T2659	T2629	parataxis	2C,were
R1566	T2660	T2659	compound	Figure,2C
R1567	T2661	T2659	punct	),2C
R1568	T2662	T2629	punct	.,were
R1569	T2664	T2665	nsubj	SC,is
R1570	T2666	T2664	punct	-,SC
R1571	T2667	T2664	nummod	333,SC
R1572	T2668	T2669	det	a,antibody
R1573	T2669	T2665	attr	antibody,is
R1574	T2670	T2669	nmod	rabbit,antibody
R1575	T2671	T2669	amod	anti-Sam68,antibody
R1576	T2672	T2673	dep	that,raised
R1577	T2673	T2669	relcl	raised,antibody
R1578	T2674	T2673	auxpass	was,raised
R1579	T2675	T2673	prep	against,raised
R1580	T2676	T2677	det	the,acids
R1581	T2677	T2675	pobj	acids,against
R1582	T2678	T2679	npadvmod	C,terminal
R1583	T2679	T2677	amod	terminal,acids
R1584	T2680	T2679	punct	-,terminal
R1585	T2681	T2677	nummod	20,acids
R1586	T2682	T2677	compound	amino,acids
R1587	T2683	T2677	prep	of,acids
R1588	T2684	T2683	pobj	Sam68,of
R1589	T2685	T2686	punct	[,47
R1590	T2686	T2665	parataxis	47,is
R1591	T2687	T2686	punct	],47
R1592	T2688	T2665	punct	.,is
R1593	T2690	T2691	det	These,data
R1594	T2691	T2692	nsubj	data,confirmed
R1595	T2693	T2694	det	the,generation
R1596	T2694	T2692	dobj	generation,confirmed
R1597	T2695	T2694	prep	of,generation
R1598	T2696	T2697	det	a,mouse
R1599	T2697	T2695	pobj	mouse,of
R1600	T2698	T2697	amod	deficient,mouse
R1601	T2699	T2698	prep	in,deficient
R1602	T2700	T2699	pobj	Sam68,in
R1603	T2701	T2692	punct	.,confirmed
R1604	T2703	T2704	det	The,genotypes
R1605	T2704	T2705	nsubj	genotypes,exhibited
R1606	T2706	T2704	prep	of,genotypes
R1607	T2707	T2706	pobj	offspring,of
R1608	T2708	T2707	prep	from,offspring
R1609	T2709	T2710	compound	heterozygote,intercrosses
R1610	T2710	T2708	pobj	intercrosses,from
R1611	T2711	T2712	det	a,segregation
R1612	T2712	T2705	dobj	segregation,exhibited
R1613	T2713	T2712	amod	Mendelian,segregation
R1614	T2714	T2705	prep	at,exhibited
R1615	T2715	T2714	pobj	E18.5,at
R1616	T2716	T2717	punct	(,Table
R1617	T2717	T2705	parataxis	Table,exhibited
R1618	T2718	T2717	nummod	1,Table
R1619	T2719	T2717	punct	),Table
R1620	T2720	T2705	punct	.,exhibited
R1621	T2722	T2723	prep	Despite,died
R1622	T2724	T2725	det	the,lack
R1623	T2725	T2722	pobj	lack,Despite
R1624	T2726	T2725	prep	of,lack
R1625	T2727	T2728	amod	visible,deformity
R1626	T2728	T2726	pobj	deformity,of
R1627	T2729	T2723	punct	", ",died
R1628	T2730	T2723	nsubj	many,died
R1629	T2731	T2730	prep	of,many
R1630	T2732	T2733	det	the,pups
R1631	T2733	T2731	pobj	pups,of
R1632	T2734	T2733	nmod	Sam68,pups
R1633	T2735	T2734	punct	−,Sam68
R1634	T2736	T2734	punct	/,Sam68
R1635	T2737	T2734	punct	−,Sam68
R1636	T2738	T2723	prep	at,died
R1637	T2739	T2738	pobj	birth,at
R1638	T2740	T2723	prep	of,died
R1639	T2741	T2742	amod	unknown,causes
R1640	T2742	T2740	pobj	causes,of
R1641	T2743	T2723	punct	.,died
R1642	T2745	T2746	nmod	Sam68,mice
R1643	T2746	T2750	nsubj	mice,were
R1644	T2747	T2745	punct	+,Sam68
R1645	T2748	T2745	punct	/,Sam68
R1646	T2749	T2745	punct	-,Sam68
R1647	T2751	T2752	advmod	phenotypically,normal
R1648	T2752	T2750	acomp	normal,were
R1649	T2753	T2750	cc	and,were
R1650	T2754	T2755	nmod	Sam68,pups
R1651	T2755	T2759	nsubj	pups,lived
R1652	T2756	T2754	punct	−,Sam68
R1653	T2757	T2754	punct	/,Sam68
R1654	T2758	T2754	punct	−,Sam68
R1655	T2759	T2750	conj	lived,were
R1656	T2760	T2761	dep	that,survived
R1657	T2761	T2755	relcl	survived,pups
R1658	T2762	T2763	det	the,period
R1659	T2763	T2761	dobj	period,survived
R1660	T2764	T2763	amod	perinatal,period
R1661	T2765	T2759	advmod	invariably,lived
R1662	T2766	T2759	prep	to,lived
R1663	T2767	T2768	amod	old,age
R1664	T2768	T2766	pobj	age,to
R1665	T2769	T2759	punct	.,lived
R1666	T2771	T2772	prep	Despite,develop
R1667	T2773	T2771	pobj	evidence,Despite
R1668	T2774	T2775	mark	that,expressed
R1669	T2775	T2773	acl	expressed,evidence
R1670	T2776	T2777	compound	Sam68,mRNA
R1671	T2777	T2775	nsubjpass	mRNA,expressed
R1672	T2778	T2775	auxpass	is,expressed
R1673	T2779	T2775	advmod	widely,expressed
R1674	T2780	T2775	cc	and,expressed
R1675	T2781	T2775	conj	phosphorylated,expressed
R1676	T2782	T2781	prep	in,phosphorylated
R1677	T2783	T2782	pobj	mitosis,in
R1678	T2784	T2785	punct	[,42
R1679	T2785	T2775	parataxis	42,expressed
R1680	T2786	T2785	nummod	41,42
R1681	T2787	T2785	punct	",",42
R1682	T2788	T2785	punct	],42
R1683	T2789	T2772	punct	", ",develop
R1684	T2790	T2791	det	the,mice
R1685	T2791	T2772	nsubj	mice,develop
R1686	T2792	T2791	nmod	Sam68,mice
R1687	T2793	T2792	punct	−,Sam68
R1688	T2794	T2792	punct	/,Sam68
R1689	T2795	T2792	punct	−,Sam68
R1690	T2796	T2772	aux	did,develop
R1691	T2797	T2772	neg	not,develop
R1692	T2798	T2772	dobj	tumors,develop
R1693	T2799	T2772	cc	and,develop
R1694	T2800	T2772	conj	showed,develop
R1695	T2801	T2802	det	no,illnesses
R1696	T2802	T2800	dobj	illnesses,showed
R1697	T2803	T2802	amod	immunologic,illnesses
R1698	T2804	T2803	cc	or,immunologic
R1699	T2805	T2806	amod	other,major
R1700	T2806	T2803	conj	major,immunologic
R1701	T2807	T2772	punct	.,develop
R1702	T2809	T2810	nmod	Sam68,mice
R1703	T2810	T2814	nsubj	mice,have
R1704	T2811	T2809	punct	−,Sam68
R1705	T2812	T2809	punct	/,Sam68
R1706	T2813	T2809	punct	−,Sam68
R1707	T2815	T2814	aux	did,have
R1708	T2816	T2814	punct	", ",have
R1709	T2817	T2814	advmod	however,have
R1710	T2818	T2814	punct	", ",have
R1711	T2819	T2814	dobj	difficulty,have
R1712	T2820	T2819	acl	breeding,difficulty
R1713	T2821	T2814	prep	due,have
R1714	T2822	T2821	pcomp	to,due
R1715	T2823	T2824	amod	male,infertility
R1716	T2824	T2821	pobj	infertility,due
R1717	T2825	T2814	cc	and,have
R1718	T2826	T2827	det	the,females
R1719	T2827	T2828	nsubj	females,provided
R1720	T2828	T2814	conj	provided,have
R1721	T2829	T2828	advmod	rarely,provided
R1722	T2830	T2831	amod	adequate,care
R1723	T2831	T2828	dobj	care,provided
R1724	T2832	T2828	dative	to,provided
R1725	T2833	T2834	poss	their,young
R1726	T2834	T2832	pobj	young,to
R1727	T2835	T2828	punct	.,provided
R1732	T3035	T3036	compound	Sam68,Deficiency
R1733	T3036	T3037	nsubj	Deficiency,Protects
R1734	T3038	T3037	dobj	Mice,Protects
R1735	T3039	T3037	prep	from,Protects
R1736	T3040	T3041	npadvmod	Age,Related
R1737	T3041	T3043	amod	Related,Loss
R1738	T3042	T3041	punct	-,Related
R1739	T3043	T3039	pobj	Loss,from
R1740	T3044	T3043	compound	Bone,Loss
R1741	T3046	T3047	nmod	Src,animals
R1742	T3047	T3049	nsubjpass	animals,known
R1743	T3048	T3047	amod	null,animals
R1744	T3050	T3049	auxpass	are,known
R1745	T3051	T3052	aux	to,have
R1746	T3052	T3049	xcomp	have,known
R1747	T3053	T3054	compound	bone,metabolism
R1748	T3054	T3055	compound	metabolism,defects
R1749	T3055	T3052	dobj	defects,have
R1750	T3056	T3057	punct	[,48
R1751	T3057	T3049	parataxis	48,known
R1752	T3058	T3057	punct	],48
R1753	T3059	T3049	punct	", ",known
R1754	T3060	T3049	cc	and,known
R1755	T3061	T3062	mark	since,is
R1756	T3062	T3064	advcl	is,decided
R1757	T3063	T3062	nsubj	Sam68,is
R1758	T3064	T3049	conj	decided,known
R1759	T3065	T3066	det	a,substrate
R1760	T3066	T3062	attr	substrate,is
R1761	T3067	T3066	prep	of,substrate
R1762	T3068	T3067	pobj	Src,of
R1763	T3069	T3064	punct	", ",decided
R1764	T3070	T3064	nsubj	we,decided
R1765	T3071	T3072	aux	to,analyze
R1766	T3072	T3064	xcomp	analyze,decided
R1767	T3073	T3074	det	the,mice
R1768	T3074	T3072	dobj	mice,analyze
R1769	T3075	T3074	compound	Sam68,mice
R1770	T3076	T3072	prep	for,analyze
R1771	T3077	T3078	amod	skeletal,abnormalities
R1772	T3078	T3076	pobj	abnormalities,for
R1773	T3079	T3064	punct	.,decided
R1774	T3081	T3082	nsubjpass	Cohorts,euthanized
R1775	T3083	T3081	prep	of,Cohorts
R1776	T3084	T3085	nmod	Sam68,mice
R1777	T3085	T3083	pobj	mice,of
R1778	T3086	T3084	punct	+,Sam68
R1779	T3087	T3084	punct	/,Sam68
R1780	T3088	T3084	punct	+,Sam68
R1781	T3089	T3084	cc	and,Sam68
R1782	T3090	T3084	conj	Sam68,Sam68
R1783	T3091	T3090	punct	−,Sam68
R1784	T3092	T3090	punct	/,Sam68
R1785	T3093	T3090	punct	−,Sam68
R1786	T3094	T3082	auxpass	were,euthanized
R1787	T3095	T3082	prep	at,euthanized
R1788	T3096	T3097	nummod	4,months
R1789	T3097	T3095	pobj	months,at
R1790	T3098	T3096	cc	and,4
R1791	T3099	T3096	conj	12,4
R1792	T3100	T3097	prep	of,months
R1793	T3101	T3100	pobj	age,of
R1794	T3102	T3082	prep	for,euthanized
R1795	T3103	T3104	amod	skeletal,phenotyping
R1796	T3104	T3102	pobj	phenotyping,for
R1797	T3105	T3082	punct	.,euthanized
R1798	T3107	T3108	aux	To,minimize
R1799	T3108	T3109	advcl	minimize,selected
R1800	T3110	T3108	dobj	differences,minimize
R1801	T3111	T3110	prep	in,differences
R1802	T3112	T3113	det	the,phenotype
R1803	T3113	T3111	pobj	phenotype,in
R1804	T3114	T3113	compound	bone,phenotype
R1805	T3115	T3116	dep	that,arise
R1806	T3116	T3110	relcl	arise,differences
R1807	T3117	T3116	aux	might,arise
R1808	T3118	T3116	advcl	secondary,arise
R1809	T3119	T3118	prep	to,secondary
R1810	T3120	T3121	nmod	gender,differences
R1811	T3121	T3119	pobj	differences,to
R1812	T3122	T3120	cc	or,gender
R1813	T3123	T3120	conj	weight,gender
R1814	T3124	T3109	punct	", ",selected
R1815	T3125	T3109	nsubj	we,selected
R1816	T3126	T3127	npadvmod	age,matched
R1817	T3127	T3129	amod	matched,mice
R1818	T3128	T3127	punct	-,matched
R1819	T3129	T3109	dobj	mice,selected
R1820	T3130	T3129	amod	female,mice
R1821	T3131	T3109	prep	for,selected
R1822	T3132	T3133	det	these,analyses
R1823	T3133	T3131	pobj	analyses,for
R1824	T3134	T3109	punct	.,selected
R1825	T3136	T3137	det	The,mice
R1826	T3137	T3139	nsubj	mice,demonstrated
R1827	T3138	T3137	amod	female,mice
R1828	T3140	T3141	amod	similar,increases
R1829	T3141	T3139	dobj	increases,demonstrated
R1830	T3142	T3141	prep	in,increases
R1831	T3143	T3144	compound	body,weight
R1832	T3144	T3142	pobj	weight,in
R1833	T3145	T3146	punct	", ",weighed
R1834	T3146	T3141	parataxis	weighed,increases
R1835	T3147	T3146	mark	although,weighed
R1836	T3148	T3149	nummod	4,month
R1837	T3149	T3151	npadvmod	month,old
R1838	T3150	T3149	punct	-,month
R1839	T3151	T3153	amod	old,mice
R1840	T3152	T3151	punct	-,old
R1841	T3153	T3146	nsubj	mice,weighed
R1842	T3154	T3153	nmod	Sam68,mice
R1843	T3155	T3154	punct	−,Sam68
R1844	T3156	T3154	punct	/,Sam68
R1845	T3157	T3154	punct	−,Sam68
R1846	T3158	T3159	amod	less,than
R1847	T3159	T3146	prep	than,weighed
R1848	T3160	T3161	nmod	Sam68,mice
R1849	T3161	T3159	pobj	mice,than
R1850	T3162	T3160	punct	+,Sam68
R1851	T3163	T3160	punct	/,Sam68
R1852	T3164	T3160	punct	+,Sam68
R1853	T3165	T3141	punct	", ",increases
R1854	T3166	T3141	cc	and,increases
R1855	T3167	T3168	amod	similar,changes
R1856	T3168	T3141	conj	changes,increases
R1857	T3169	T3168	prep	in,changes
R1858	T3170	T3171	compound	bone,lengths
R1859	T3171	T3169	pobj	lengths,in
R1860	T3172	T3168	prep	in,changes
R1861	T3173	T3174	det	the,skeleton
R1862	T3174	T3172	pobj	skeleton,in
R1863	T3175	T3174	amod	axial,skeleton
R1864	T3176	T3175	cc	and,axial
R1865	T3177	T3175	conj	appendicular,axial
R1866	T3178	T3168	prep	between,changes
R1867	T3179	T3180	nummod	4,months
R1868	T3180	T3178	pobj	months,between
R1869	T3181	T3179	cc	and,4
R1870	T3182	T3179	conj	12,4
R1871	T3183	T3180	prep	of,months
R1872	T3184	T3183	pobj	age,of
R1873	T3185	T3186	punct	(,Table
R1874	T3186	T3139	parataxis	Table,demonstrated
R1875	T3187	T3186	nummod	2,Table
R1876	T3188	T3186	punct	),Table
R1877	T3189	T3139	punct	.,demonstrated
R1878	T3191	T3192	compound	Faxitron,radiography
R1879	T3192	T3193	nsubj	radiography,revealed
R1880	T3194	T3195	punct	(,Corporation
R1881	T3195	T3192	parataxis	Corporation,radiography
R1882	T3196	T3195	compound	Faxitron,Corporation
R1883	T3197	T3198	compound	X,ray
R1884	T3198	T3195	compound	ray,Corporation
R1885	T3199	T3198	punct	-,ray
R1886	T3200	T3195	punct	", ",Corporation
R1887	T3201	T3195	npadvmod	Wheeling,Corporation
R1888	T3202	T3195	punct	", ",Corporation
R1889	T3203	T3195	npadvmod	Illinois,Corporation
R1890	T3204	T3195	punct	", ",Corporation
R1891	T3205	T3206	compound	United,States
R1892	T3206	T3195	npadvmod	States,Corporation
R1893	T3207	T3195	punct	),Corporation
R1894	T3208	T3209	punct	(,3A
R1895	T3209	T3192	parataxis	3A,radiography
R1896	T3210	T3209	compound	Figure,3A
R1897	T3211	T3209	punct	),3A
R1898	T3212	T3192	cc	and,radiography
R1899	T3213	T3214	amod	micro–computed,tomography
R1900	T3214	T3192	conj	tomography,radiography
R1901	T3215	T3216	punct	(,CT
R1902	T3216	T3214	parataxis	CT,tomography
R1903	T3217	T3216	punct	),CT
R1904	T3218	T3219	punct	(,3B
R1905	T3219	T3214	parataxis	3B,tomography
R1906	T3220	T3219	compound	Figure,3B
R1907	T3221	T3219	punct	),3B
R1908	T3222	T3223	amod	significant,thinning
R1909	T3223	T3193	dobj	thinning,revealed
R1910	T3224	T3223	amod	cortical,thinning
R1911	T3225	T3226	punct	(,arrow
R1912	T3226	T3223	parataxis	arrow,thinning
R1913	T3227	T3226	punct	),arrow
R1914	T3228	T3223	cc	and,thinning
R1915	T3229	T3230	det	a,reduction
R1916	T3230	T3223	conj	reduction,thinning
R1917	T3231	T3230	prep	in,reduction
R1918	T3232	T3233	amod	metaphyseal,bone
R1919	T3233	T3231	pobj	bone,in
R1920	T3234	T3235	punct	(,asterisk
R1921	T3235	T3230	parataxis	asterisk,reduction
R1922	T3236	T3235	punct	),asterisk
R1923	T3237	T3223	prep	in,thinning
R1924	T3238	T3239	det	the,femora
R1925	T3239	T3237	pobj	femora,in
R1926	T3240	T3239	amod	distal,femora
R1927	T3241	T3239	prep	of,femora
R1928	T3242	T3243	nummod	12,month
R1929	T3243	T3245	npadvmod	month,old
R1930	T3244	T3243	punct	-,month
R1931	T3245	T3247	amod	old,mice
R1932	T3246	T3245	punct	-,old
R1933	T3247	T3241	pobj	mice,of
R1934	T3248	T3247	nmod	Sam68,mice
R1935	T3249	T3248	punct	+,Sam68
R1936	T3250	T3248	punct	/,Sam68
R1937	T3251	T3248	punct	+,Sam68
R1938	T3252	T3223	prep	compared,thinning
R1939	T3253	T3252	prep	with,compared
R1940	T3254	T3255	nummod	4,month
R1941	T3255	T3257	npadvmod	month,old
R1942	T3256	T3255	punct	-,month
R1943	T3257	T3259	amod	old,mice
R1944	T3258	T3257	punct	-,old
R1945	T3259	T3253	pobj	mice,with
R1946	T3260	T3259	prep	of,mice
R1947	T3261	T3262	preconj	either,genotype
R1948	T3262	T3260	pobj	genotype,of
R1949	T3263	T3259	cc	and,mice
R1950	T3264	T3265	nummod	12,month
R1951	T3265	T3267	npadvmod	month,old
R1952	T3266	T3265	punct	-,month
R1953	T3267	T3269	amod	old,mice
R1954	T3268	T3267	punct	-,old
R1955	T3269	T3259	conj	mice,mice
R1956	T3270	T3269	nmod	Sam68,mice
R1957	T3271	T3270	punct	−,Sam68
R1958	T3272	T3270	punct	/,Sam68
R1959	T3273	T3270	punct	−,Sam68
R1960	T3274	T3193	punct	.,revealed
R1961	T3276	T3277	amod	Similar,reductions
R1962	T3277	T3278	nsubjpass	reductions,shown
R1963	T3279	T3277	prep	in,reductions
R1964	T3280	T3281	amod	trabecular,bone
R1965	T3281	T3279	pobj	bone,in
R1966	T3282	T3278	auxpass	were,shown
R1967	T3283	T3278	prep	by,shown
R1968	T3284	T3283	pobj	Faxitron,by
R1969	T3285	T3284	cc	and,Faxitron
R1970	T3286	T3284	conj	micro-CT,Faxitron
R1971	T3287	T3278	prep	in,shown
R1972	T3288	T3289	det	the,vertebrae
R1973	T3289	T3287	pobj	vertebrae,in
R1974	T3290	T3289	amod	fifth,vertebrae
R1975	T3291	T3289	compound	lumbar,vertebrae
R1976	T3292	T3289	prep	of,vertebrae
R1977	T3293	T3294	det	the,mice
R1978	T3294	T3292	pobj	mice,of
R1979	T3295	T3296	nummod	12,month
R1980	T3296	T3298	npadvmod	month,old
R1981	T3297	T3296	punct	-,month
R1982	T3298	T3294	amod	old,mice
R1983	T3299	T3298	punct	-,old
R1984	T3300	T3294	nmod	Sam68,mice
R1985	T3301	T3300	punct	+,Sam68
R1986	T3302	T3300	punct	/,Sam68
R1987	T3303	T3300	punct	+,Sam68
R1988	T3304	T3287	cc	but,in
R1989	T3305	T3304	neg	not,but
R1990	T3306	T3287	conj	in,in
R1991	T3307	T3308	det	the,mice
R1992	T3308	T3306	pobj	mice,in
R1993	T3309	T3308	nmod	Sam68,mice
R1994	T3310	T3309	punct	−,Sam68
R1995	T3311	T3309	punct	/,Sam68
R1996	T3312	T3309	punct	−,Sam68
R1997	T3313	T3314	punct	(,data
R1998	T3314	T3278	meta	data,shown
R1999	T3315	T3314	amod	unpublished,data
R2000	T3316	T3314	punct	),data
R2001	T3317	T3278	punct	.,shown
R2002	T3319	T3320	amod	Total,content
R2003	T3320	T3324	nsubj	content,increased
R2004	T3321	T3320	compound	body,content
R2005	T3322	T3320	compound	bone,content
R2006	T3323	T3320	compound	mineral,content
R2007	T3325	T3320	punct	(,content
R2008	T3326	T3320	appos	BMC,content
R2009	T3327	T3320	punct	),content
R2010	T3328	T3320	punct	", ",content
R2011	T3329	T3320	acl	quantified,content
R2012	T3330	T3329	prep	with,quantified
R2013	T3331	T3332	det	a,densitometer
R2014	T3332	T3330	pobj	densitometer,with
R2015	T3333	T3334	amod	Lunar,PIXImus
R2016	T3334	T3332	compound	PIXImus,densitometer
R2017	T3335	T3332	compound	mouse,densitometer
R2018	T3336	T3337	punct	(,Lunar
R2019	T3337	T3332	parataxis	Lunar,densitometer
R2020	T3338	T3337	compound	GE,Lunar
R2021	T3339	T3337	punct	-,Lunar
R2022	T3340	T3337	punct	", ",Lunar
R2023	T3341	T3337	npadvmod	Madison,Lunar
R2024	T3342	T3337	punct	", ",Lunar
R2025	T3343	T3337	npadvmod	Wisconsin,Lunar
R2026	T3344	T3337	punct	", ",Lunar
R2027	T3345	T3346	compound	United,States
R2028	T3346	T3337	npadvmod	States,Lunar
R2029	T3347	T3337	punct	),Lunar
R2030	T3348	T3324	punct	", ",increased
R2031	T3349	T3324	prep	in,increased
R2032	T3350	T3351	preconj	both,Sam68
R2033	T3351	T3352	nmod	Sam68,mice
R2034	T3352	T3349	pobj	mice,in
R2035	T3353	T3351	punct	+,Sam68
R2036	T3354	T3351	punct	/,Sam68
R2037	T3355	T3351	punct	+,Sam68
R2038	T3356	T3351	cc	and,Sam68
R2039	T3357	T3351	conj	Sam68,Sam68
R2040	T3358	T3357	punct	−,Sam68
R2041	T3359	T3357	punct	/,Sam68
R2042	T3360	T3357	punct	−,Sam68
R2043	T3361	T3352	prep	between,mice
R2044	T3362	T3363	nummod	4,months
R2045	T3363	T3361	pobj	months,between
R2046	T3364	T3363	cc	and,months
R2047	T3365	T3366	nummod	12,months
R2048	T3366	T3363	conj	months,months
R2049	T3367	T3363	prep	of,months
R2050	T3368	T3367	pobj	age,of
R2051	T3369	T3324	punct	", ",increased
R2052	T3370	T3324	cc	but,increased
R2053	T3371	T3372	advmod	only,reached
R2054	T3372	T3324	conj	reached,increased
R2055	T3373	T3372	dobj	significance,reached
R2056	T3374	T3372	prep	in,reached
R2057	T3375	T3376	det	the,mice
R2058	T3376	T3374	pobj	mice,in
R2059	T3377	T3376	nmod	Sam68,mice
R2060	T3378	T3377	punct	−,Sam68
R2061	T3379	T3377	punct	/,Sam68
R2062	T3380	T3377	punct	−,Sam68
R2063	T3381	T3382	punct	(,Table
R2064	T3382	T3372	parataxis	Table,reached
R2065	T3383	T3382	nummod	2,Table
R2066	T3384	T3382	punct	),Table
R2067	T3385	T3324	punct	.,increased
R2068	T3387	T3388	advmod	Similarly,seen
R2069	T3389	T3388	punct	", ",seen
R2070	T3390	T3391	det	a,increase
R2071	T3391	T3388	nsubjpass	increase,seen
R2072	T3392	T3391	amod	greater,increase
R2073	T3393	T3391	prep	in,increase
R2074	T3394	T3393	pobj	BMC,in
R2075	T3395	T3388	auxpass	was,seen
R2076	T3396	T3388	prep	in,seen
R2077	T3397	T3398	det	the,femur
R2078	T3398	T3396	pobj	femur,in
R2079	T3399	T3398	cc	and,femur
R2080	T3400	T3398	conj	vertebra,femur
R2081	T3401	T3398	prep	in,femur
R2082	T3402	T3403	det	the,mice
R2083	T3403	T3401	pobj	mice,in
R2084	T3404	T3403	nmod	Sam68,mice
R2085	T3405	T3404	punct	−,Sam68
R2086	T3406	T3404	punct	/,Sam68
R2087	T3407	T3404	punct	−,Sam68
R2088	T3408	T3388	punct	.,seen
R2089	T3410	T3411	compound	Bone,mineral
R2090	T3411	T3412	compound	mineral,density
R2091	T3412	T3413	nsubj	density,remained
R2092	T3414	T3412	punct	(,density
R2093	T3415	T3412	appos	BMD,density
R2094	T3416	T3413	punct	),remained
R2095	T3417	T3413	acomp	constant,remained
R2096	T3418	T3413	cc	or,remained
R2097	T3419	T3413	conj	decreased,remained
R2098	T3420	T3413	prep	in,remained
R2099	T3421	T3422	det	the,mice
R2100	T3422	T3420	pobj	mice,in
R2101	T3423	T3424	amod	wild,type
R2102	T3424	T3422	compound	type,mice
R2103	T3425	T3413	cc	but,remained
R2104	T3426	T3413	conj	increased,remained
R2105	T3427	T3426	advmod	significantly,increased
R2106	T3428	T3426	prep	in,increased
R2107	T3429	T3430	det	the,body
R2108	T3430	T3428	pobj	body,in
R2109	T3431	T3430	amod	total,body
R2110	T3432	T3428	cc	and,in
R2111	T3433	T3428	conj	in,in
R2112	T3434	T3435	det	the,regions
R2113	T3435	T3433	pobj	regions,in
R2114	T3436	T3435	amod	femoral,regions
R2115	T3437	T3436	cc	and,femoral
R2116	T3438	T3436	conj	vertebral,femoral
R2117	T3439	T3435	prep	of,regions
R2118	T3440	T3439	pobj	interest,of
R2119	T3441	T3426	prep	in,increased
R2120	T3442	T3443	det	the,Sam68
R2121	T3443	T3441	pobj	Sam68,in
R2122	T3444	T3443	punct	−,Sam68
R2123	T3445	T3443	punct	/,Sam68
R2124	T3446	T3443	punct	−,Sam68
R2125	T3447	T3448	punct	(,Table
R2126	T3448	T3426	parataxis	Table,increased
R2127	T3449	T3448	nummod	2,Table
R2128	T3450	T3448	punct	),Table
R2129	T3451	T3413	punct	.,remained
R2130	T3453	T3454	det	These,data
R2131	T3454	T3455	nsubj	data,showed
R2132	T3456	T3457	mark	that,continued
R2133	T3457	T3455	ccomp	continued,showed
R2134	T3458	T3459	nmod	Sam68,mice
R2135	T3459	T3457	nsubj	mice,continued
R2136	T3460	T3458	punct	−,Sam68
R2137	T3461	T3458	punct	/,Sam68
R2138	T3462	T3458	punct	−,Sam68
R2139	T3463	T3464	aux	to,thrive
R2140	T3464	T3457	xcomp	thrive,continued
R2141	T3465	T3464	cc	and,thrive
R2142	T3466	T3464	conj	accrue,thrive
R2143	T3467	T3466	dobj	bone,accrue
R2144	T3468	T3466	prep	in,accrue
R2145	T3469	T3470	det	the,skeleton
R2146	T3470	T3468	pobj	skeleton,in
R2147	T3471	T3470	amod	axial,skeleton
R2148	T3472	T3471	cc	and,axial
R2149	T3473	T3471	conj	appendicular,axial
R2150	T3474	T3464	prep	for,thrive
R2151	T3475	T3476	amod	longer,12
R2152	T3476	T3478	nummod	12,months
R2153	T3477	T3476	quantmod	than,12
R2154	T3478	T3474	pobj	months,for
R2155	T3479	T3455	punct	.,showed
R2156	T3481	T3482	nsubj	This,was
R2157	T3483	T3482	prep	in,was
R2158	T3484	T3483	pobj	contrast,in
R2159	T3485	T3484	prep	to,contrast
R2160	T3486	T3487	det	the,situation
R2161	T3487	T3485	pobj	situation,to
R2162	T3488	T3487	prep	in,situation
R2163	T3489	T3490	npadvmod	age,matched
R2164	T3490	T3492	amod	matched,controls
R2165	T3491	T3490	punct	-,matched
R2166	T3492	T3488	pobj	controls,in
R2167	T3493	T3492	punct	", ",controls
R2168	T3494	T3492	compound	littermate,controls
R2169	T3495	T3496	prep	in,lost
R2170	T3496	T3487	relcl	lost,situation
R2171	T3497	T3495	pobj	which,in
R2172	T3498	T3499	det	a,amount
R2173	T3499	T3496	nsubjpass	amount,lost
R2174	T3500	T3499	amod	significant,amount
R2175	T3501	T3499	prep	of,amount
R2176	T3502	T3501	pobj	bone,of
R2177	T3503	T3496	auxpass	was,lost
R2178	T3504	T3496	prep	over,lost
R2179	T3505	T3506	det	the,timeframe
R2180	T3506	T3504	pobj	timeframe,over
R2181	T3507	T3506	amod	same,timeframe
R2182	T3508	T3482	punct	.,was
R2183	T3587	T3588	advmod	Three,Dimensional
R2184	T3588	T3590	amod	Dimensional,Architecture
R2185	T3589	T3588	punct	-,Dimensional
R2186	T3590	T3591	nsubjpass	Architecture,Preserved
R2187	T3592	T3590	prep	of,Architecture
R2188	T3593	T3592	pobj	Bone,of
R2189	T3594	T3591	auxpass	Is,Preserved
R2190	T3595	T3591	prep	in,Preserved
R2191	T3596	T3597	amod	Aged,Mice
R2192	T3597	T3595	pobj	Mice,in
R2193	T3598	T3597	nmod	Sam68,Mice
R2194	T3599	T3598	punct	−,Sam68
R2195	T3600	T3598	punct	/,Sam68
R2196	T3601	T3598	punct	−,Sam68
R2197	T3603	T3604	compound	Bone,loss
R2198	T3604	T3605	nsubj	loss,are
R2199	T3606	T3604	cc	and,loss
R2200	T3607	T3608	amod	compromised,architecture
R2201	T3608	T3604	conj	architecture,loss
R2202	T3609	T3610	amod	characteristic,features
R2203	T3610	T3605	attr	features,are
R2204	T3611	T3610	prep	of,features
R2205	T3612	T3613	det	the,skeletons
R2206	T3613	T3611	pobj	skeletons,of
R2207	T3614	T3613	prep	of,skeletons
R2208	T3615	T3616	amod	aged,mice
R2209	T3616	T3614	pobj	mice,of
R2210	T3617	T3616	nmod	C57BL,mice
R2211	T3618	T3617	punct	/,C57BL
R2212	T3619	T3617	nummod	6,C57BL
R2213	T3620	T3605	cc	and,are
R2214	T3621	T3605	conj	resemble,are
R2215	T3622	T3623	det	the,features
R2216	T3623	T3621	dobj	features,resemble
R2217	T3624	T3623	amod	clinical,features
R2218	T3625	T3623	prep	of,features
R2219	T3626	T3627	npadvmod	age,related
R2220	T3627	T3629	amod	related,loss
R2221	T3628	T3627	punct	-,related
R2222	T3629	T3625	pobj	loss,of
R2223	T3630	T3629	compound	bone,loss
R2224	T3631	T3629	prep	in,loss
R2225	T3632	T3631	pobj	humans,in
R2226	T3633	T3634	dep	that,predispose
R2227	T3634	T3623	relcl	predispose,features
R2228	T3635	T3634	aux	can,predispose
R2229	T3636	T3637	det	an,individual
R2230	T3637	T3634	dobj	individual,predispose
R2231	T3638	T3634	prep	to,predispose
R2232	T3639	T3638	pobj	fracture,to
R2233	T3640	T3605	punct	.,are
R2234	T3642	T3643	nsubj	Quantification,confirmed
R2235	T3644	T3642	prep	of,Quantification
R2236	T3645	T3646	det	the,data
R2237	T3646	T3644	pobj	data,of
R2238	T3647	T3646	compound	micro-CT,data
R2239	T3648	T3646	acl	shown,data
R2240	T3649	T3648	prep	in,shown
R2241	T3650	T3651	compound	Figure,3B
R2242	T3651	T3649	pobj	3B,in
R2243	T3652	T3653	det	the,reduction
R2244	T3653	T3643	dobj	reduction,confirmed
R2245	T3654	T3653	prep	in,reduction
R2246	T3655	T3656	compound	bone,volume
R2247	T3656	T3654	pobj	volume,in
R2248	T3657	T3653	prep	compared,reduction
R2249	T3658	T3657	prep	with,compared
R2250	T3659	T3660	compound	tissue,volume
R2251	T3660	T3658	pobj	volume,with
R2252	T3661	T3662	punct	(,4A
R2253	T3662	T3660	parataxis	4A,volume
R2254	T3663	T3664	compound	BV,TV
R2255	T3664	T3662	dep	TV,4A
R2256	T3665	T3664	punct	/,TV
R2257	T3666	T3662	punct	;,4A
R2258	T3667	T3662	compound	Figure,4A
R2259	T3668	T3662	punct	", ",4A
R2260	T3669	T3662	amod	left,4A
R2261	T3670	T3662	punct	),4A
R2262	T3671	T3660	prep	in,volume
R2263	T3672	T3673	det	the,mice
R2264	T3673	T3671	pobj	mice,in
R2265	T3674	T3675	nummod	12,month
R2266	T3675	T3677	npadvmod	month,old
R2267	T3676	T3675	punct	-,month
R2268	T3677	T3673	amod	old,mice
R2269	T3678	T3677	punct	-,old
R2270	T3679	T3673	nmod	Sam68,mice
R2271	T3680	T3679	punct	+,Sam68
R2272	T3681	T3679	punct	/,Sam68
R2273	T3682	T3679	punct	+,Sam68
R2274	T3683	T3684	punct	(,bars
R2275	T3684	T3673	parataxis	bars,mice
R2276	T3685	T3684	amod	hatched,bars
R2277	T3686	T3684	punct	),bars
R2278	T3687	T3660	prep	compared,volume
R2279	T3688	T3687	prep	with,compared
R2280	T3689	T3690	nummod	4,month
R2281	T3690	T3692	npadvmod	month,old
R2282	T3691	T3690	punct	-,month
R2283	T3692	T3694	amod	old,mice
R2284	T3693	T3692	punct	-,old
R2285	T3694	T3688	pobj	mice,with
R2286	T3695	T3694	prep	of,mice
R2287	T3696	T3697	det	both,genotypes
R2288	T3697	T3695	pobj	genotypes,of
R2289	T3698	T3699	punct	(,bars
R2290	T3699	T3694	parataxis	bars,mice
R2291	T3700	T3699	amod	solid,bars
R2292	T3701	T3699	punct	),bars
R2293	T3702	T3694	cc	and,mice
R2294	T3703	T3704	nummod	12,month
R2295	T3704	T3706	npadvmod	month,old
R2296	T3705	T3704	punct	-,month
R2297	T3706	T3708	amod	old,mice
R2298	T3707	T3706	punct	-,old
R2299	T3708	T3694	conj	mice,mice
R2300	T3709	T3708	nmod	Sam68,mice
R2301	T3710	T3709	punct	−,Sam68
R2302	T3711	T3709	punct	/,Sam68
R2303	T3712	T3709	punct	−,Sam68
R2304	T3713	T3714	punct	(,bars
R2305	T3714	T3708	parataxis	bars,mice
R2306	T3715	T3714	amod	stippled,bars
R2307	T3716	T3714	punct	),bars
R2308	T3717	T3643	punct	.,confirmed
R2309	T3719	T3720	nsubjpass	This,associated
R2310	T3721	T3720	auxpass	was,associated
R2311	T3722	T3720	prep	with,associated
R2312	T3723	T3724	det	a,increase
R2313	T3724	T3722	pobj	increase,with
R2314	T3725	T3724	amod	significant,increase
R2315	T3726	T3727	punct	(,denoted
R2316	T3727	T3724	parataxis	denoted,increase
R2317	T3728	T3729	nsubj	p,0.01
R2318	T3729	T3727	ccomp	0.01,denoted
R2319	T3730	T3729	punct	<,0.01
R2320	T3731	T3727	punct	;,denoted
R2321	T3732	T3727	agent	by,denoted
R2322	T3733	T3734	det	the,asterisks
R2323	T3734	T3732	pobj	asterisks,by
R2324	T3735	T3727	punct	),denoted
R2325	T3736	T3724	prep	in,increase
R2326	T3737	T3738	det	the,index
R2327	T3738	T3736	pobj	index,in
R2328	T3739	T3738	compound	structure,index
R2329	T3740	T3738	compound	model,index
R2330	T3741	T3738	punct	", ",index
R2331	T3742	T3743	dep	which,measures
R2332	T3743	T3738	relcl	measures,index
R2333	T3744	T3745	det	the,ratio
R2334	T3745	T3743	dobj	ratio,measures
R2335	T3746	T3745	prep	of,ratio
R2336	T3747	T3748	npadvmod	plate,like
R2337	T3748	T3746	pobj	like,of
R2338	T3749	T3748	punct	-,like
R2339	T3750	T3748	prep	to,like
R2340	T3751	T3752	npadvmod	rod,like
R2341	T3752	T3750	pobj	like,to
R2342	T3753	T3752	punct	-,like
R2343	T3754	T3748	appos	structures,like
R2344	T3755	T3756	punct	(,4A
R2345	T3756	T3743	parataxis	4A,measures
R2346	T3757	T3756	compound	Figure,4A
R2347	T3758	T3756	punct	", ",4A
R2348	T3759	T3756	appos	right,4A
R2349	T3760	T3756	punct	),4A
R2350	T3761	T3720	punct	.,associated
R2351	T3763	T3764	det	A,increase
R2352	T3764	T3766	nsubj	increase,was
R2353	T3765	T3764	amod	quantifiable,increase
R2354	T3767	T3764	prep	in,increase
R2355	T3768	T3769	det	the,separation
R2356	T3769	T3767	pobj	separation,in
R2357	T3770	T3769	nmod	mean,separation
R2358	T3771	T3769	amod	trabecular,separation
R2359	T3772	T3769	punct	(,separation
R2360	T3773	T3769	appos	Tb.Sp,separation
R2361	T3774	T3769	punct	),separation
R2362	T3775	T3776	punct	(,data
R2363	T3776	T3769	parataxis	data,separation
R2364	T3777	T3776	amod	unpublished,data
R2365	T3778	T3776	punct	),data
R2366	T3779	T3764	prep	in,increase
R2367	T3780	T3781	nummod	12,month
R2368	T3781	T3783	npadvmod	month,old
R2369	T3782	T3781	punct	-,month
R2370	T3783	T3785	amod	old,mice
R2371	T3784	T3783	punct	-,old
R2372	T3785	T3779	pobj	mice,in
R2373	T3786	T3785	nmod	Sam68,mice
R2374	T3787	T3786	punct	+,Sam68
R2375	T3788	T3786	punct	/,Sam68
R2376	T3789	T3786	punct	+,Sam68
R2377	T3790	T3766	prep	due,was
R2378	T3791	T3790	pcomp	to,due
R2379	T3792	T3793	det	an,increase
R2380	T3793	T3790	pobj	increase,due
R2381	T3794	T3793	prep	in,increase
R2382	T3795	T3796	det	the,percentage
R2383	T3796	T3794	pobj	percentage,in
R2384	T3797	T3796	prep	of,percentage
R2385	T3798	T3797	pobj	spaces,of
R2386	T3799	T3798	acl	falling,spaces
R2387	T3800	T3799	prep	in,falling
R2388	T3801	T3802	det	the,range
R2389	T3802	T3800	pobj	range,in
R2390	T3803	T3802	prep	of,range
R2391	T3804	T3805	quantmod	350,700
R2392	T3805	T3807	nummod	700,μm
R2393	T3806	T3805	quantmod	to,700
R2394	T3807	T3803	pobj	μm,of
R2395	T3808	T3809	punct	(,4B
R2396	T3809	T3766	parataxis	4B,was
R2397	T3810	T3809	compound	Figure,4B
R2398	T3811	T3809	punct	", ",4B
R2399	T3812	T3813	amod	red,line
R2400	T3813	T3809	appos	line,4B
R2401	T3814	T3813	amod	hatched,line
R2402	T3815	T3809	punct	),4B
R2403	T3816	T3766	punct	.,was
R2404	T3818	T3819	amod	Trabecular,thickness
R2405	T3819	T3820	nsubj	thickness,remained
R2406	T3821	T3820	acomp	constant,remained
R2407	T3822	T3820	prep	among,remained
R2408	T3823	T3824	det	the,groups
R2409	T3824	T3822	pobj	groups,among
R2410	T3825	T3824	amod	different,groups
R2411	T3826	T3824	prep	of,groups
R2412	T3827	T3826	pobj	mice,of
R2413	T3828	T3829	punct	(,data
R2414	T3829	T3820	meta	data,remained
R2415	T3830	T3829	amod	unpublished,data
R2416	T3831	T3829	punct	),data
R2417	T3832	T3820	punct	.,remained
R2418	T3834	T3835	prep	In,meant
R2419	T3836	T3834	pobj	effect,In
R2420	T3837	T3835	punct	", ",meant
R2421	T3838	T3835	nsubj	this,meant
R2422	T3839	T3840	mark	that,were
R2423	T3840	T3835	ccomp	were,meant
R2424	T3841	T3840	expl	there,were
R2425	T3842	T3843	amod	fewer,trabeculae
R2426	T3843	T3840	attr	trabeculae,were
R2427	T3844	T3843	punct	", ",trabeculae
R2428	T3845	T3846	advmod	rather,than
R2429	T3846	T3843	cc	than,trabeculae
R2430	T3847	T3848	amod	equivalent,numbers
R2431	T3848	T3843	conj	numbers,trabeculae
R2432	T3849	T3848	prep	of,numbers
R2433	T3850	T3851	amod	thin,trabeculae
R2434	T3851	T3849	pobj	trabeculae,of
R2435	T3852	T3843	punct	", ",trabeculae
R2436	T3853	T3843	prep	in,trabeculae
R2437	T3854	T3855	det	the,mice
R2438	T3855	T3853	pobj	mice,in
R2439	T3856	T3857	nummod	12,month
R2440	T3857	T3859	npadvmod	month,old
R2441	T3858	T3857	punct	-,month
R2442	T3859	T3855	amod	old,mice
R2443	T3860	T3859	punct	-,old
R2444	T3861	T3855	nmod	Sam68,mice
R2445	T3862	T3861	punct	+,Sam68
R2446	T3863	T3861	punct	/,Sam68
R2447	T3864	T3861	punct	+,Sam68
R2448	T3865	T3843	prep	compared,trabeculae
R2449	T3866	T3865	prep	with,compared
R2450	T3867	T3866	pobj	any,with
R2451	T3868	T3867	prep	of,any
R2452	T3869	T3870	det	the,groups
R2453	T3870	T3868	pobj	groups,of
R2454	T3871	T3870	amod	other,groups
R2455	T3872	T3870	prep	of,groups
R2456	T3873	T3872	pobj	mice,of
R2457	T3874	T3835	punct	.,meant
R2458	T4163	T4164	compound	Bone,Remodeling
R2459	T4164	T4165	nsubjpass	Remodeling,Preserved
R2460	T4166	T4165	auxpass	Is,Preserved
R2461	T4167	T4165	prep	in,Preserved
R2462	T4168	T4169	amod	Aged,Mice
R2463	T4169	T4167	pobj	Mice,in
R2464	T4170	T4169	nmod	Sam68,Mice
R2465	T4171	T4170	punct	−,Sam68
R2466	T4172	T4170	punct	/,Sam68
R2467	T4173	T4170	punct	−,Sam68
R2468	T4175	T4176	aux	To,define
R2469	T4176	T4178	advcl	define,prepared
R2470	T4177	T4176	advmod	further,define
R2471	T4179	T4180	det	the,mechanisms
R2472	T4180	T4176	dobj	mechanisms,define
R2473	T4181	T4180	acl	involved,mechanisms
R2474	T4182	T4181	prep	in,involved
R2475	T4183	T4184	det	the,preservation
R2476	T4184	T4182	pobj	preservation,in
R2477	T4185	T4184	prep	of,preservation
R2478	T4186	T4187	compound	bone,mass
R2479	T4187	T4185	pobj	mass,of
R2480	T4188	T4184	prep	in,preservation
R2481	T4189	T4190	amod	aged,mice
R2482	T4190	T4188	pobj	mice,in
R2483	T4191	T4190	nmod	Sam68,mice
R2484	T4192	T4191	punct	−,Sam68
R2485	T4193	T4191	punct	/,Sam68
R2486	T4194	T4191	punct	−,Sam68
R2487	T4195	T4178	punct	", ",prepared
R2488	T4196	T4178	nsubj	we,prepared
R2489	T4197	T4178	dobj	sections,prepared
R2490	T4198	T4178	prep	from,prepared
R2491	T4199	T4200	npadvmod	plastic,embedded
R2492	T4200	T4202	amod	embedded,femora
R2493	T4201	T4200	punct	-,embedded
R2494	T4202	T4198	pobj	femora,from
R2495	T4203	T4202	cc	and,femora
R2496	T4204	T4202	conj	tibia,femora
R2497	T4205	T4206	aux	to,evaluate
R2498	T4206	T4178	advcl	evaluate,prepared
R2499	T4207	T4208	nmod	osteoblast,activity
R2500	T4208	T4206	dobj	activity,evaluate
R2501	T4209	T4207	cc	and,osteoblast
R2502	T4210	T4207	conj	osteoclast,osteoblast
R2503	T4211	T4212	punct	(,Figure
R2504	T4212	T4178	parataxis	Figure,prepared
R2505	T4213	T4212	nummod	5,Figure
R2506	T4214	T4212	punct	),Figure
R2507	T4215	T4178	punct	.,prepared
R2508	T4217	T4218	advmod	In,situ
R2509	T4218	T4219	amod	situ,staining
R2510	T4219	T4222	nsubjpass	staining,used
R2511	T4220	T4219	nmod	enzyme,staining
R2512	T4221	T4219	amod	histochemical,staining
R2513	T4223	T4219	prep	for,staining
R2514	T4224	T4225	nmod	alkaline,phosphatase
R2515	T4225	T4226	nmod	phosphatase,activity
R2516	T4226	T4223	pobj	activity,for
R2517	T4227	T4225	punct	(,phosphatase
R2518	T4228	T4225	appos	ALP,phosphatase
R2519	T4229	T4230	punct	;,stain
R2520	T4230	T4228	parataxis	stain,ALP
R2521	T4231	T4230	amod	brown,stain
R2522	T4232	T4230	punct	),stain
R2523	T4233	T4222	auxpass	was,used
R2524	T4234	T4222	prep	as,used
R2525	T4235	T4236	det	a,biomarker
R2526	T4236	T4234	pobj	biomarker,as
R2527	T4237	T4236	prep	for,biomarker
R2528	T4238	T4237	pobj	osteoblasts,for
R2529	T4239	T4238	cc	and,osteoblasts
R2530	T4240	T4241	npadvmod	tartrate,resistant
R2531	T4241	T4243	amod	resistant,activity
R2532	T4242	T4241	punct	-,resistant
R2533	T4243	T4238	conj	activity,osteoblasts
R2534	T4244	T4243	nmod	ALP,activity
R2535	T4245	T4246	punct	(,stain
R2536	T4246	T4243	parataxis	stain,activity
R2537	T4247	T4248	npadvmod	tartrate,resistant
R2538	T4248	T4250	amod	resistant,phosphatase
R2539	T4249	T4248	punct	-,resistant
R2540	T4250	T4246	dep	phosphatase,stain
R2541	T4251	T4250	compound	acid,phosphatase
R2542	T4252	T4250	punct	[,phosphatase
R2543	T4253	T4250	appos	TRAP,phosphatase
R2544	T4254	T4246	punct	],stain
R2545	T4255	T4246	punct	;,stain
R2546	T4256	T4246	amod	red,stain
R2547	T4257	T4246	punct	),stain
R2548	T4258	T4222	prep	as,used
R2549	T4259	T4260	det	a,marker
R2550	T4260	T4258	pobj	marker,as
R2551	T4261	T4260	prep	for,marker
R2552	T4262	T4261	pobj	osteoclasts,for
R2553	T4263	T4222	punct	.,used
R2554	T4265	T4266	amod	Little,difference
R2555	T4266	T4267	nsubjpass	difference,seen
R2556	T4268	T4267	auxpass	was,seen
R2557	T4269	T4267	prep	between,seen
R2558	T4270	T4271	nmod	Sam68,mice
R2559	T4271	T4269	pobj	mice,between
R2560	T4272	T4270	punct	+,Sam68
R2561	T4273	T4270	punct	/,Sam68
R2562	T4274	T4270	punct	+,Sam68
R2563	T4275	T4276	punct	(,5A
R2564	T4276	T4270	parataxis	5A,Sam68
R2565	T4277	T4276	compound	Figure,5A
R2566	T4278	T4276	cc	and,5A
R2567	T4279	T4276	conj	5B,5A
R2568	T4280	T4276	punct	),5A
R2569	T4281	T4270	cc	and,Sam68
R2570	T4282	T4270	conj	Sam68,Sam68
R2571	T4283	T4282	punct	−,Sam68
R2572	T4284	T4282	punct	/,Sam68
R2573	T4285	T4282	punct	−,Sam68
R2574	T4286	T4287	punct	(,5C
R2575	T4287	T4282	parataxis	5C,Sam68
R2576	T4288	T4287	compound	Figure,5C
R2577	T4289	T4287	cc	and,5C
R2578	T4290	T4287	conj	5D,5C
R2579	T4291	T4287	punct	),5C
R2580	T4292	T4267	prep	at,seen
R2581	T4293	T4294	nummod	4,months
R2582	T4294	T4292	pobj	months,at
R2583	T4295	T4294	prep	of,months
R2584	T4296	T4295	pobj	age,of
R2585	T4297	T4267	punct	.,seen
R2586	T4299	T4300	npadvmod	ALP,positive
R2587	T4300	T4305	amod	positive,cells
R2588	T4301	T4299	punct	-,ALP
R2589	T4302	T4299	cc	and,ALP
R2590	T4303	T4299	conj	TRAP,ALP
R2591	T4304	T4300	punct	-,positive
R2592	T4305	T4306	nsubjpass	cells,reduced
R2593	T4307	T4306	auxpass	were,reduced
R2594	T4308	T4306	prep	in,reduced
R2595	T4309	T4310	det	the,mice
R2596	T4310	T4308	pobj	mice,in
R2597	T4311	T4312	nummod	12,month
R2598	T4312	T4314	npadvmod	month,old
R2599	T4313	T4312	punct	-,month
R2600	T4314	T4310	amod	old,mice
R2601	T4315	T4314	punct	-,old
R2602	T4316	T4310	nmod	Sam68,mice
R2603	T4317	T4316	punct	+,Sam68
R2604	T4318	T4316	punct	/,Sam68
R2605	T4319	T4316	punct	+,Sam68
R2606	T4320	T4321	punct	(,5E
R2607	T4321	T4306	parataxis	5E,reduced
R2608	T4322	T4321	compound	Figure,5E
R2609	T4323	T4321	cc	and,5E
R2610	T4324	T4321	conj	5F,5E
R2611	T4325	T4321	punct	),5E
R2612	T4326	T4306	cc	and,reduced
R2613	T4327	T4306	conj	remained,reduced
R2614	T4328	T4327	acomp	unchanged,remained
R2615	T4329	T4327	prep	in,remained
R2616	T4330	T4331	nummod	12,month
R2617	T4331	T4333	npadvmod	month,old
R2618	T4332	T4331	punct	-,month
R2619	T4333	T4335	amod	old,mice
R2620	T4334	T4333	punct	-,old
R2621	T4335	T4329	pobj	mice,in
R2622	T4336	T4335	nmod	Sam68,mice
R2623	T4337	T4336	punct	−,Sam68
R2624	T4338	T4336	punct	/,Sam68
R2625	T4339	T4336	punct	−,Sam68
R2626	T4340	T4341	punct	(,5G
R2627	T4341	T4327	parataxis	5G,remained
R2628	T4342	T4341	compound	Figure,5G
R2629	T4343	T4341	cc	and,5G
R2630	T4344	T4341	conj	5H,5G
R2631	T4345	T4341	punct	),5G
R2632	T4346	T4306	punct	.,reduced
R2633	T4348	T4349	det	The,reduction
R2634	T4349	T4350	nsubj	reduction,argued
R2635	T4351	T4349	prep	in,reduction
R2636	T4352	T4353	preconj	both,osteoblast
R2637	T4353	T4354	nmod	osteoblast,activity
R2638	T4354	T4351	pobj	activity,in
R2639	T4355	T4353	cc	and,osteoblast
R2640	T4356	T4353	conj	osteoclast,osteoblast
R2641	T4357	T4349	prep	in,reduction
R2642	T4358	T4359	det	the,mice
R2643	T4359	T4357	pobj	mice,in
R2644	T4360	T4361	nummod	12,month
R2645	T4361	T4363	npadvmod	month,old
R2646	T4362	T4361	punct	-,month
R2647	T4363	T4359	amod	old,mice
R2648	T4364	T4363	punct	-,old
R2649	T4365	T4359	nmod	Sam68,mice
R2650	T4366	T4365	punct	+,Sam68
R2651	T4367	T4365	punct	/,Sam68
R2652	T4368	T4365	punct	+,Sam68
R2653	T4369	T4350	prep	against,argued
R2654	T4370	T4371	nsubjpass	bone,lost
R2655	T4371	T4369	pcomp	lost,against
R2656	T4372	T4371	auxpass	being,lost
R2657	T4373	T4374	advmod	primarily,due
R2658	T4374	T4371	prep	due,lost
R2659	T4375	T4374	pcomp	to,due
R2660	T4376	T4377	det	a,increase
R2661	T4377	T4374	pobj	increase,due
R2662	T4378	T4377	amod	relative,increase
R2663	T4379	T4377	prep	in,increase
R2664	T4380	T4379	pobj	osteoclast,in
R2665	T4381	T4380	prep	over,osteoclast
R2666	T4382	T4381	pobj	osteoblast,over
R2667	T4383	T4380	appos	activity,osteoclast
R2668	T4384	T4371	punct	", ",lost
R2669	T4385	T4386	mark	as,seen
R2670	T4386	T4371	advcl	seen,lost
R2671	T4387	T4386	prep	in,seen
R2672	T4388	T4389	amod	high,turnover
R2673	T4389	T4390	compound	turnover,disease
R2674	T4390	T4387	pobj	disease,in
R2675	T4391	T4392	punct	[,49
R2676	T4392	T4350	parataxis	49,argued
R2677	T4393	T4392	punct	],49
R2678	T4394	T4350	punct	.,argued
R2679	T4396	T4397	amod	Histomorphometric,analyses
R2680	T4397	T4398	nsubj	analyses,corroborated
R2681	T4399	T4400	punct	[,50
R2682	T4400	T4397	parataxis	50,analyses
R2683	T4401	T4400	punct	],50
R2684	T4402	T4397	prep	of,analyses
R2685	T4403	T4404	det	the,bones
R2686	T4404	T4402	pobj	bones,of
R2687	T4405	T4404	amod	long,bones
R2688	T4406	T4407	punct	(,Table
R2689	T4407	T4397	parataxis	Table,analyses
R2690	T4408	T4407	nummod	3,Table
R2691	T4409	T4407	punct	),Table
R2692	T4410	T4411	det	the,evidence
R2693	T4411	T4398	dobj	evidence,corroborated
R2694	T4412	T4411	amod	radiologic,evidence
R2695	T4413	T4411	prep	of,evidence
R2696	T4414	T4415	npadvmod	age,related
R2697	T4415	T4417	amod	related,loss
R2698	T4416	T4415	punct	-,related
R2699	T4417	T4413	pobj	loss,of
R2700	T4418	T4417	compound	bone,loss
R2701	T4419	T4398	punct	.,corroborated
R2702	T4421	T4422	compound	Bone,volume
R2703	T4422	T4423	nsubjpass	volume,reduced
R2704	T4424	T4422	punct	(,volume
R2705	T4425	T4426	compound	BV,TV
R2706	T4426	T4422	appos	TV,volume
R2707	T4427	T4426	punct	/,TV
R2708	T4428	T4422	punct	),volume
R2709	T4429	T4422	punct	", ",volume
R2710	T4430	T4431	advmod	newly,formed
R2711	T4431	T4432	amod	formed,osteoid
R2712	T4432	T4422	conj	osteoid,volume
R2713	T4433	T4432	punct	(,osteoid
R2714	T4434	T4435	compound	OV,TV
R2715	T4435	T4432	appos	TV,osteoid
R2716	T4436	T4435	punct	/,TV
R2717	T4437	T4432	punct	),osteoid
R2718	T4438	T4432	punct	", ",osteoid
R2719	T4439	T4432	cc	and,osteoid
R2720	T4440	T4441	compound	mineral,rate
R2721	T4441	T4432	conj	rate,osteoid
R2722	T4442	T4441	compound	apposition,rate
R2723	T4443	T4441	punct	(,rate
R2724	T4444	T4441	appos	MAR,rate
R2725	T4445	T4423	punct	),reduced
R2726	T4446	T4423	auxpass	were,reduced
R2727	T4447	T4423	dep	all,reduced
R2728	T4448	T4423	advmod	significantly,reduced
R2729	T4449	T4423	prep	in,reduced
R2730	T4450	T4451	nummod	12,month
R2731	T4451	T4453	npadvmod	month,old
R2732	T4452	T4451	punct	-,month
R2733	T4453	T4455	amod	old,mice
R2734	T4454	T4453	punct	-,old
R2735	T4455	T4449	pobj	mice,in
R2736	T4456	T4455	nmod	Sam68,mice
R2737	T4457	T4456	punct	+,Sam68
R2738	T4458	T4456	punct	/,Sam68
R2739	T4459	T4456	punct	+,Sam68
R2740	T4460	T4423	prep	compared,reduced
R2741	T4461	T4460	prep	with,compared
R2742	T4462	T4463	nummod	4,month
R2743	T4463	T4465	npadvmod	month,old
R2744	T4464	T4463	punct	-,month
R2745	T4465	T4467	amod	old,mice
R2746	T4466	T4465	punct	-,old
R2747	T4467	T4461	pobj	mice,with
R2748	T4468	T4467	nmod	Sam68,mice
R2749	T4469	T4468	punct	+,Sam68
R2750	T4470	T4468	punct	/,Sam68
R2751	T4471	T4468	punct	+,Sam68
R2752	T4472	T4423	punct	.,reduced
R2753	T4474	T4475	det	These,reductions
R2754	T4475	T4476	nsubjpass	reductions,associated
R2755	T4477	T4476	auxpass	were,associated
R2756	T4478	T4476	prep	with,associated
R2757	T4479	T4480	det	a,increase
R2758	T4480	T4478	pobj	increase,with
R2759	T4481	T4480	amod	significant,increase
R2760	T4482	T4480	prep	in,increase
R2761	T4483	T4484	compound	marrow,fat
R2762	T4484	T4482	pobj	fat,in
R2763	T4485	T4486	punct	(,TV
R2764	T4486	T4480	parataxis	TV,increase
R2765	T4487	T4486	compound	FV,TV
R2766	T4488	T4486	punct	/,TV
R2767	T4489	T4486	punct	),TV
R2768	T4490	T4480	cc	and,increase
R2769	T4491	T4492	amod	decreased,numbers
R2770	T4492	T4480	conj	numbers,increase
R2771	T4493	T4492	prep	of,numbers
R2772	T4494	T4493	pobj	osteoblasts,of
R2773	T4495	T4496	punct	(,TV
R2774	T4496	T4494	parataxis	TV,osteoblasts
R2775	T4497	T4496	compound	nOB,TV
R2776	T4498	T4496	punct	/,TV
R2777	T4499	T4496	punct	),TV
R2778	T4500	T4494	cc	and,osteoblasts
R2779	T4501	T4494	conj	osteoclasts,osteoblasts
R2780	T4502	T4503	punct	(,TV
R2781	T4503	T4501	parataxis	TV,osteoclasts
R2782	T4504	T4503	compound	nOC,TV
R2783	T4505	T4503	punct	/,TV
R2784	T4506	T4503	punct	),TV
R2785	T4507	T4492	prep	per,numbers
R2786	T4508	T4509	compound	tissue,volume
R2787	T4509	T4507	pobj	volume,per
R2788	T4510	T4511	punct	(,Table
R2789	T4511	T4476	parataxis	Table,associated
R2790	T4512	T4511	nummod	3,Table
R2791	T4513	T4511	punct	),Table
R2792	T4514	T4476	punct	.,associated
R2793	T4516	T4517	det	These,results
R2794	T4517	T4518	nsubj	results,were
R2795	T4519	T4518	prep	in,were
R2796	T4520	T4519	pobj	contrast,in
R2797	T4521	T4520	prep	to,contrast
R2798	T4522	T4521	pobj	those,to
R2799	T4523	T4522	prep	of,those
R2800	T4524	T4525	det	the,mice
R2801	T4525	T4523	pobj	mice,of
R2802	T4526	T4527	nummod	12,month
R2803	T4527	T4529	npadvmod	month,old
R2804	T4528	T4527	punct	-,month
R2805	T4529	T4525	amod	old,mice
R2806	T4530	T4529	punct	-,old
R2807	T4531	T4525	nmod	Sam68,mice
R2808	T4532	T4531	punct	−,Sam68
R2809	T4533	T4531	punct	/,Sam68
R2810	T4534	T4531	punct	−,Sam68
R2811	T4535	T4536	prep	in,resembled
R2812	T4536	T4522	relcl	resembled,those
R2813	T4537	T4535	pobj	which,in
R2814	T4538	T4539	det	all,parameters
R2815	T4539	T4536	nsubj	parameters,resembled
R2816	T4540	T4539	amod	histomorphometric,parameters
R2817	T4541	T4539	punct	", ",parameters
R2818	T4542	T4539	prep	including,parameters
R2819	T4543	T4544	compound	marrow,fat
R2820	T4544	T4542	pobj	fat,including
R2821	T4545	T4536	punct	", ",resembled
R2822	T4546	T4536	dobj	those,resembled
R2823	T4547	T4546	prep	of,those
R2824	T4548	T4549	amod	young,mice
R2825	T4549	T4547	pobj	mice,of
R2826	T4550	T4549	prep	of,mice
R2827	T4551	T4552	preconj	either,genotype
R2828	T4552	T4550	pobj	genotype,of
R2829	T4553	T4554	punct	(,Table
R2830	T4554	T4536	parataxis	Table,resembled
R2831	T4555	T4554	nummod	3,Table
R2832	T4556	T4554	punct	),Table
R2833	T4557	T4518	punct	.,were
R2834	T4559	T4560	advmod	When,expressed
R2835	T4560	T4563	advcl	expressed,were
R2836	T4561	T4560	nsubjpass	cells,expressed
R2837	T4562	T4560	auxpass	were,expressed
R2838	T4564	T4560	prep	as,expressed
R2839	T4565	T4566	det	a,function
R2840	T4566	T4564	pobj	function,as
R2841	T4567	T4566	prep	of,function
R2842	T4568	T4569	det	the,perimeter
R2843	T4569	T4567	pobj	perimeter,of
R2844	T4570	T4569	compound	bone,perimeter
R2845	T4571	T4572	punct	(,BP
R2846	T4572	T4560	parataxis	BP,expressed
R2847	T4573	T4572	compound	nOB,BP
R2848	T4574	T4572	punct	/,BP
R2849	T4575	T4572	punct	", ",BP
R2850	T4576	T4577	compound	nOC,BP
R2851	T4577	T4572	appos	BP,BP
R2852	T4578	T4577	punct	/,BP
R2853	T4579	T4572	punct	),BP
R2854	T4580	T4563	punct	", ",were
R2855	T4581	T4563	expl	there,were
R2856	T4582	T4583	det	no,differences
R2857	T4583	T4563	attr	differences,were
R2858	T4584	T4583	amod	statistical,differences
R2859	T4585	T4563	cc	and,were
R2860	T4586	T4587	det	the,ratio
R2861	T4587	T4588	nsubj	ratio,was
R2862	T4588	T4563	conj	was,were
R2863	T4589	T4587	prep	of,ratio
R2864	T4590	T4589	pobj	osteoblasts,of
R2865	T4591	T4590	prep	to,osteoblasts
R2866	T4592	T4591	pobj	osteoclasts,to
R2867	T4593	T4588	acomp	similar,was
R2868	T4594	T4588	prep	in,was
R2869	T4595	T4596	det	all,groups
R2870	T4596	T4594	pobj	groups,in
R2871	T4597	T4596	prep	of,groups
R2872	T4598	T4597	pobj	mice,of
R2873	T4599	T4600	punct	(,Table
R2874	T4600	T4588	parataxis	Table,was
R2875	T4601	T4600	nummod	3,Table
R2876	T4602	T4600	punct	),Table
R2877	T4603	T4563	punct	.,were
R2878	T4605	T4606	amod	Circulating,levels
R2879	T4606	T4607	nsubj	levels,showed
R2880	T4608	T4606	prep	of,levels
R2881	T4609	T4610	compound	serum,telopeptide
R2882	T4610	T4608	pobj	telopeptide,of
R2883	T4611	T4610	compound	C,telopeptide
R2884	T4612	T4610	punct	-,telopeptide
R2885	T4613	T4614	punct	(,Diagnostics
R2886	T4614	T4610	parataxis	Diagnostics,telopeptide
R2887	T4615	T4614	dep	sCTX,Diagnostics
R2888	T4616	T4614	punct	;,Diagnostics
R2889	T4617	T4614	compound	Roche,Diagnostics
R2890	T4618	T4614	punct	", ",Diagnostics
R2891	T4619	T4614	npadvmod	Mannheim,Diagnostics
R2892	T4620	T4614	punct	", ",Diagnostics
R2893	T4621	T4614	npadvmod	Germany,Diagnostics
R2894	T4622	T4614	punct	),Diagnostics
R2895	T4623	T4610	cc	and,telopeptide
R2896	T4624	T4610	conj	ALP,telopeptide
R2897	T4625	T4626	amod	little,difference
R2898	T4626	T4607	dobj	difference,showed
R2899	T4627	T4607	prep	among,showed
R2900	T4628	T4629	det	the,groups
R2901	T4629	T4627	pobj	groups,among
R2902	T4630	T4607	punct	", ",showed
R2903	T4631	T4607	prep	except,showed
R2904	T4632	T4631	prep	for,except
R2905	T4633	T4634	det	a,decrease
R2906	T4634	T4632	pobj	decrease,for
R2907	T4635	T4634	amod	small,decrease
R2908	T4636	T4634	prep	in,decrease
R2909	T4637	T4638	nummod	12,month
R2910	T4638	T4640	npadvmod	month,old
R2911	T4639	T4638	punct	-,month
R2912	T4640	T4642	amod	old,mice
R2913	T4641	T4640	punct	-,old
R2914	T4642	T4636	pobj	mice,in
R2915	T4643	T4642	nmod	Sam68,mice
R2916	T4644	T4643	punct	−,Sam68
R2917	T4645	T4643	punct	/,Sam68
R2918	T4646	T4643	punct	−,Sam68
R2919	T4647	T4642	cc	and,mice
R2920	T4648	T4649	punct	(,S3
R2921	T4649	T4642	conj	S3,mice
R2922	T4650	T4649	compound	Dataset,S3
R2923	T4651	T4607	punct	),showed
R2924	T4652	T4607	punct	.,showed
R2925	T4654	T4655	compound	Serum,estrogen
R2926	T4655	T4656	nsubjpass	estrogen,decreased
R2927	T4657	T4656	auxpass	was,decreased
R2928	T4658	T4656	advmod	significantly,decreased
R2929	T4659	T4656	prep	in,decreased
R2930	T4660	T4661	det	all,mice
R2931	T4661	T4659	pobj	mice,in
R2932	T4662	T4663	nummod	12,month
R2933	T4663	T4665	npadvmod	month,old
R2934	T4664	T4663	punct	-,month
R2935	T4665	T4661	amod	old,mice
R2936	T4666	T4665	punct	-,old
R2937	T4667	T4656	advmod	regardless,decreased
R2938	T4668	T4667	prep	of,regardless
R2939	T4669	T4668	pobj	genotype,of
R2940	T4670	T4656	prep	with,decreased
R2941	T4671	T4672	det	a,increase
R2942	T4672	T4670	pobj	increase,with
R2943	T4673	T4672	amod	reciprocal,increase
R2944	T4674	T4672	prep	in,increase
R2945	T4675	T4676	nmod	interleukin,levels
R2946	T4676	T4674	pobj	levels,in
R2947	T4677	T4675	punct	-,interleukin
R2948	T4678	T4675	nummod	6,interleukin
R2949	T4679	T4680	punct	(,S3
R2950	T4680	T4656	parataxis	S3,decreased
R2951	T4681	T4680	compound	Dataset,S3
R2952	T4682	T4680	punct	),S3
R2953	T4683	T4656	punct	.,decreased
R2954	T4685	T4686	prep	Given,measured
R2955	T4687	T4688	det	the,involvement
R2956	T4688	T4685	pobj	involvement,Given
R2957	T4689	T4688	prep	of,involvement
R2958	T4690	T4689	pobj	leptin,of
R2959	T4691	T4688	prep	in,involvement
R2960	T4692	T4691	pcomp	regulating,in
R2961	T4693	T4694	nmod	body,mass
R2962	T4694	T4692	dobj	mass,regulating
R2963	T4695	T4693	cc	and,body
R2964	T4696	T4693	conj	bone,body
R2965	T4697	T4686	punct	", ",measured
R2966	T4698	T4699	compound	serum,leptin
R2967	T4699	T4686	nsubjpass	leptin,measured
R2968	T4700	T4686	auxpass	was,measured
R2969	T4701	T4686	prep	in,measured
R2970	T4702	T4703	nmod	Sam68,mice
R2971	T4703	T4701	pobj	mice,in
R2972	T4704	T4702	punct	+,Sam68
R2973	T4705	T4702	punct	/,Sam68
R2974	T4706	T4702	punct	+,Sam68
R2975	T4707	T4702	cc	and,Sam68
R2976	T4708	T4702	conj	Sam68,Sam68
R2977	T4709	T4708	punct	−,Sam68
R2978	T4710	T4708	punct	/,Sam68
R2979	T4711	T4708	punct	−,Sam68
R2980	T4712	T4686	punct	.,measured
R2981	T4714	T4715	nummod	Twelve,month
R2982	T4715	T4717	npadvmod	month,old
R2983	T4716	T4715	punct	-,month
R2984	T4717	T4719	amod	old,mice
R2985	T4718	T4717	punct	-,old
R2986	T4719	T4724	nsubj	mice,had
R2987	T4720	T4719	nmod	Sam68,mice
R2988	T4721	T4720	punct	−,Sam68
R2989	T4722	T4720	punct	/,Sam68
R2990	T4723	T4720	punct	−,Sam68
R2991	T4725	T4726	advmod	significantly,lower
R2992	T4726	T4727	amod	lower,levels
R2993	T4727	T4724	dobj	levels,had
R2994	T4728	T4727	prep	than,levels
R2995	T4729	T4730	amod	young,mice
R2996	T4730	T4728	pobj	mice,than
R2997	T4731	T4729	cc	and,young
R2998	T4732	T4729	conj	old,young
R2999	T4733	T4730	nmod	Sam68,mice
R3000	T4734	T4733	punct	+,Sam68
R3001	T4735	T4733	punct	/,Sam68
R3002	T4736	T4733	punct	+,Sam68
R3003	T4737	T4730	cc	and,mice
R3004	T4738	T4739	amod	young,mice
R3005	T4739	T4730	conj	mice,mice
R3006	T4740	T4739	nmod	Sam68,mice
R3007	T4741	T4740	punct	−,Sam68
R3008	T4742	T4740	punct	/,Sam68
R3009	T4743	T4740	punct	−,Sam68
R3010	T4744	T4745	punct	(,S3
R3011	T4745	T4724	parataxis	S3,had
R3012	T4746	T4745	compound	Dataset,S3
R3013	T4747	T4745	punct	),S3
R3014	T4748	T4724	punct	.,had
R3015	T4750	T4751	advcl	Taken,suggested
R3016	T4752	T4750	advmod	together,Taken
R3017	T4753	T4751	punct	", ",suggested
R3018	T4754	T4755	det	these,observations
R3019	T4755	T4751	nsubj	observations,suggested
R3020	T4756	T4757	mark	that,was
R3021	T4757	T4751	ccomp	was,suggested
R3022	T4758	T4757	nsubj	preservation,was
R3023	T4759	T4758	prep	of,preservation
R3024	T4760	T4761	compound	bone,mass
R3025	T4761	T4759	pobj	mass,of
R3026	T4762	T4758	prep	in,preservation
R3027	T4763	T4764	det	the,mice
R3028	T4764	T4762	pobj	mice,in
R3029	T4765	T4764	nmod	Sam68,mice
R3030	T4766	T4765	punct	−,Sam68
R3031	T4767	T4765	punct	/,Sam68
R3032	T4768	T4765	punct	−,Sam68
R3033	T4769	T4757	neg	not,was
R3034	T4770	T4757	prep	due,was
R3035	T4771	T4770	advmod	primarily,due
R3036	T4772	T4770	pcomp	to,due
R3037	T4773	T4774	amod	altered,status
R3038	T4774	T4770	pobj	status,due
R3039	T4775	T4774	compound	estrogen,status
R3040	T4776	T4757	cc	but,was
R3041	T4777	T4778	aux	could,influenced
R3042	T4778	T4757	conj	influenced,was
R3043	T4779	T4778	aux	have,influenced
R3044	T4780	T4778	auxpass	been,influenced
R3045	T4781	T4778	agent	by,influenced
R3046	T4782	T4781	pobj	differences,by
R3047	T4783	T4782	prep	in,differences
R3048	T4784	T4785	amod	circulating,levels
R3049	T4785	T4783	pobj	levels,in
R3050	T4786	T4785	compound	leptin,levels
R3051	T4787	T4751	punct	.,suggested
R3052	T4956	T4957	nmod	Osteoblast,Activity
R3053	T4957	T4963	nsubjpass	Activity,Altered
R3054	T4958	T4956	punct	", ",Osteoblast
R3055	T4959	T4956	cc	but,Osteoblast
R3056	T4960	T4959	neg	Not,but
R3057	T4961	T4956	conj	Osteoclast,Osteoblast
R3058	T4962	T4957	punct	", ",Activity
R3059	T4964	T4963	auxpass	Is,Altered
R3060	T4965	T4963	prep	in,Altered
R3061	T4966	T4967	nmod	Sam68,Mice
R3062	T4967	T4965	pobj	Mice,in
R3063	T4968	T4966	punct	−,Sam68
R3064	T4969	T4966	punct	/,Sam68
R3065	T4970	T4966	punct	−,Sam68
R3066	T4971	T4972	advmod	Ex,Vivo
R3067	T4972	T4963	advmod	Vivo,Altered
R3068	T4974	T4975	nsubj	Maintenance,is
R3069	T4976	T4974	prep	of,Maintenance
R3070	T4977	T4978	compound	bone,mass
R3071	T4978	T4976	pobj	mass,of
R3072	T4979	T4974	prep	during,Maintenance
R3073	T4980	T4981	det	the,cycle
R3074	T4981	T4979	pobj	cycle,during
R3075	T4982	T4981	amod	adult,cycle
R3076	T4983	T4981	compound	remodeling,cycle
R3077	T4984	T4975	acomp	dependent,is
R3078	T4985	T4984	prep	on,dependent
R3079	T4986	T4987	det	the,coupling
R3080	T4987	T4985	pobj	coupling,on
R3081	T4988	T4987	prep	of,coupling
R3082	T4989	T4988	pobj	osteoblast,of
R3083	T4990	T4987	prep	to,coupling
R3084	T4991	T4990	pobj	osteoclast,to
R3085	T4992	T4987	appos	activity,coupling
R3086	T4993	T4975	punct	", ",is
R3087	T4994	T4995	amod	such,is
R3088	T4995	T4975	advcl	is,is
R3089	T4996	T4995	mark	that,is
R3090	T4997	T4995	expl	there,is
R3091	T4998	T4999	det	no,gain
R3092	T4999	T4995	attr	gain,is
R3093	T5000	T4999	amod	net,gain
R3094	T5001	T4999	cc	or,gain
R3095	T5002	T4999	conj	loss,gain
R3096	T5003	T4999	prep	of,gain
R3097	T5004	T5003	pobj	bone,of
R3098	T5005	T5006	punct	[,49
R3099	T5006	T4975	parataxis	49,is
R3100	T5007	T5006	punct	],49
R3101	T5008	T4975	punct	.,is
R3102	T5010	T5011	aux	To,explore
R3103	T5011	T5013	advcl	explore,examined
R3104	T5012	T5011	advmod	further,explore
R3105	T5014	T5015	det	the,advantage
R3106	T5015	T5011	dobj	advantage,explore
R3107	T5016	T5017	npadvmod	age,related
R3108	T5017	T5015	amod	related,advantage
R3109	T5018	T5017	punct	-,related
R3110	T5019	T5015	prep	of,advantage
R3111	T5020	T5021	nmod	Sam68,mice
R3112	T5021	T5019	pobj	mice,of
R3113	T5022	T5020	punct	−,Sam68
R3114	T5023	T5020	punct	/,Sam68
R3115	T5024	T5020	punct	−,Sam68
R3116	T5025	T5011	prep	with,explore
R3117	T5026	T5025	pobj	respect,with
R3118	T5027	T5026	prep	to,respect
R3119	T5028	T5029	compound	bone,preservation
R3120	T5029	T5027	pobj	preservation,to
R3121	T5030	T5013	punct	", ",examined
R3122	T5031	T5013	nsubj	we,examined
R3123	T5032	T5033	det	the,activity
R3124	T5033	T5013	dobj	activity,examined
R3125	T5034	T5033	amod	functional,activity
R3126	T5035	T5033	prep	of,activity
R3127	T5036	T5035	pobj	Sam68,of
R3128	T5037	T5036	punct	−,Sam68
R3129	T5038	T5036	punct	/,Sam68
R3130	T5039	T5036	punct	−,Sam68
R3131	T5040	T5036	appos	osteoblasts,Sam68
R3132	T5041	T5040	cc	and,osteoblasts
R3133	T5042	T5040	conj	osteoclasts,osteoblasts
R3134	T5043	T5044	advmod	ex,vivo
R3135	T5044	T5013	advmod	vivo,examined
R3136	T5045	T5046	punct	(,6A
R3137	T5046	T5013	parataxis	6A,examined
R3138	T5047	T5046	compound	Figure,6A
R3139	T5048	T5046	cc	and,6A
R3140	T5049	T5046	conj	6B,6A
R3141	T5050	T5046	punct	),6A
R3142	T5051	T5013	punct	.,examined
R3143	T5053	T5054	nsubj	Cultures,demonstrated
R3144	T5055	T5053	prep	of,Cultures
R3145	T5056	T5057	nmod	bone,marrow
R3146	T5057	T5058	nmod	marrow,cells
R3147	T5058	T5055	pobj	cells,of
R3148	T5059	T5058	amod	stromal,cells
R3149	T5060	T5053	acl	harvested,Cultures
R3150	T5061	T5060	prep	from,harvested
R3151	T5062	T5063	nummod	4,week
R3152	T5063	T5065	npadvmod	week,old
R3153	T5064	T5063	punct	-,week
R3154	T5065	T5067	amod	old,mice
R3155	T5066	T5065	punct	-,old
R3156	T5067	T5061	pobj	mice,from
R3157	T5068	T5067	nmod	Sam68,mice
R3158	T5069	T5068	punct	−,Sam68
R3159	T5070	T5068	punct	/,Sam68
R3160	T5071	T5068	punct	−,Sam68
R3161	T5072	T5060	cc	and,harvested
R3162	T5073	T5060	conj	maintained,harvested
R3163	T5074	T5073	prep	for,maintained
R3164	T5075	T5076	nummod	18,days
R3165	T5076	T5074	pobj	days,for
R3166	T5077	T5073	prep	in,maintained
R3167	T5078	T5079	compound	osteoblast,differentiation
R3168	T5079	T5080	compound	differentiation,medium
R3169	T5080	T5077	pobj	medium,in
R3170	T5081	T5082	advmod	more,intense
R3171	T5082	T5083	amod	intense,staining
R3172	T5083	T5054	dobj	staining,demonstrated
R3173	T5084	T5083	prep	for,staining
R3174	T5085	T5084	pobj	ALP,for
R3175	T5086	T5054	prep	at,demonstrated
R3176	T5087	T5088	nummod	6,days
R3177	T5088	T5086	pobj	days,at
R3178	T5089	T5090	punct	(,data
R3179	T5090	T5088	meta	data,days
R3180	T5091	T5090	amod	unpublished,data
R3181	T5092	T5090	punct	),data
R3182	T5093	T5088	cc	and,days
R3183	T5094	T5095	nummod	18,days
R3184	T5095	T5088	conj	days,days
R3185	T5096	T5097	punct	(,6A
R3186	T5097	T5095	parataxis	6A,days
R3187	T5098	T5097	compound	Figure,6A
R3188	T5099	T5097	dep	),6A
R3189	T5100	T5054	dep	", ",demonstrated
R3190	T5101	T5054	cc	and,demonstrated
R3191	T5102	T5103	amod	more,nodules
R3192	T5103	T5054	conj	nodules,demonstrated
R3193	T5104	T5103	amod	mineralized,nodules
R3194	T5105	T5103	prep	at,nodules
R3195	T5106	T5107	nummod	18,days
R3196	T5107	T5105	pobj	days,at
R3197	T5108	T5054	dep	", ",demonstrated
R3198	T5109	T5054	prep	than,demonstrated
R3199	T5110	T5111	det	the,mice
R3200	T5111	T5109	pobj	mice,than
R3201	T5112	T5111	nmod	Sam68,mice
R3202	T5113	T5112	punct	+,Sam68
R3203	T5114	T5112	punct	/,Sam68
R3204	T5115	T5112	punct	+,Sam68
R3205	T5116	T5054	dep	", ",demonstrated
R3206	T5117	T5118	advmod	even,observed
R3207	T5118	T5054	advcl	observed,demonstrated
R3208	T5119	T5118	mark	though,observed
R3209	T5120	T5121	amod	similar,amounts
R3210	T5121	T5118	nsubjpass	amounts,observed
R3211	T5122	T5121	prep	of,amounts
R3212	T5123	T5124	nmod	fibroblast,units
R3213	T5124	T5122	pobj	units,of
R3214	T5125	T5126	npadvmod	colony,forming
R3215	T5126	T5124	amod	forming,units
R3216	T5127	T5126	punct	-,forming
R3217	T5128	T5124	punct	(,units
R3218	T5129	T5130	compound	CFU,F
R3219	T5130	T5124	appos	F,units
R3220	T5131	T5130	punct	-,F
R3221	T5132	T5118	punct	),observed
R3222	T5133	T5118	auxpass	were,observed
R3223	T5134	T5135	punct	(,6A
R3224	T5135	T5118	parataxis	6A,observed
R3225	T5136	T5135	compound	Figure,6A
R3226	T5137	T5135	cc	and,6A
R3227	T5138	T5139	amod	unpublished,data
R3228	T5139	T5135	conj	data,6A
R3229	T5140	T5135	punct	),6A
R3230	T5141	T5054	punct	.,demonstrated
R3231	T5143	T5144	compound	RT,PCR
R3232	T5144	T5146	compound	PCR,analysis
R3233	T5145	T5144	punct	-,PCR
R3234	T5146	T5147	nsubj	analysis,revealed
R3235	T5148	T5146	prep	of,analysis
R3236	T5149	T5150	amod	molecular,markers
R3237	T5150	T5148	pobj	markers,of
R3238	T5151	T5150	prep	of,markers
R3239	T5152	T5153	compound	osteoblast,differentiation
R3240	T5153	T5151	pobj	differentiation,of
R3241	T5154	T5155	punct	(,S2
R3242	T5155	T5146	parataxis	S2,analysis
R3243	T5156	T5155	compound	Dataset,S2
R3244	T5157	T5155	punct	),S2
R3245	T5158	T5159	amod	similar,increases
R3246	T5159	T5147	dobj	increases,revealed
R3247	T5160	T5147	prep	over,revealed
R3248	T5161	T5160	pobj	time,over
R3249	T5162	T5147	prep	in,revealed
R3250	T5163	T5162	pobj	RNA,in
R3251	T5164	T5163	prep	from,RNA
R3252	T5165	T5166	nmod	Sam68,mice
R3253	T5166	T5164	pobj	mice,from
R3254	T5167	T5165	punct	+,Sam68
R3255	T5168	T5165	punct	/,Sam68
R3256	T5169	T5165	punct	+,Sam68
R3257	T5170	T5165	cc	and,Sam68
R3258	T5171	T5165	conj	Sam68,Sam68
R3259	T5172	T5171	punct	−,Sam68
R3260	T5173	T5171	punct	/,Sam68
R3261	T5174	T5171	punct	−,Sam68
R3262	T5175	T5147	punct	", ",revealed
R3263	T5176	T5177	mark	although,appeared
R3264	T5177	T5147	advcl	appeared,revealed
R3265	T5178	T5179	nmod	type,collagen
R3266	T5179	T5177	nsubj	collagen,appeared
R3267	T5180	T5178	nummod	I,type
R3268	T5181	T5182	aux	to,regulated
R3269	T5182	T5177	xcomp	regulated,appeared
R3270	T5183	T5182	auxpass	be,regulated
R3271	T5184	T5182	advmod	up,regulated
R3272	T5185	T5182	punct	-,regulated
R3273	T5186	T5182	prep	at,regulated
R3274	T5187	T5188	det	both,timepoints
R3275	T5188	T5186	pobj	timepoints,at
R3276	T5189	T5182	prep	in,regulated
R3277	T5190	T5191	det	the,mice
R3278	T5191	T5189	pobj	mice,in
R3279	T5192	T5191	nmod	Sam68,mice
R3280	T5193	T5192	punct	−,Sam68
R3281	T5194	T5192	punct	/,Sam68
R3282	T5195	T5192	punct	−,Sam68
R3283	T5196	T5147	punct	.,revealed
R3284	T5198	T5199	amod	Short,term
R3285	T5199	T5201	compound	term,cultures
R3286	T5200	T5199	punct	-,term
R3287	T5201	T5202	nsubj	cultures,stained
R3288	T5203	T5201	prep	of,cultures
R3289	T5204	T5205	amod	mature,osteoclasts
R3290	T5205	T5203	pobj	osteoclasts,of
R3291	T5206	T5205	acl	released,osteoclasts
R3292	T5207	T5206	prep	from,released
R3293	T5208	T5209	det	the,bones
R3294	T5209	T5207	pobj	bones,from
R3295	T5210	T5209	amod	crushed,bones
R3296	T5211	T5209	amod	long,bones
R3297	T5212	T5209	prep	of,bones
R3298	T5213	T5214	nmod	Sam68,mice
R3299	T5214	T5212	pobj	mice,of
R3300	T5215	T5213	punct	+,Sam68
R3301	T5216	T5213	punct	/,Sam68
R3302	T5217	T5213	punct	+,Sam68
R3303	T5218	T5213	cc	and,Sam68
R3304	T5219	T5213	conj	Sam68,Sam68
R3305	T5220	T5219	punct	−,Sam68
R3306	T5221	T5219	punct	/,Sam68
R3307	T5222	T5219	punct	−,Sam68
R3308	T5223	T5224	advmod	equally,well
R3309	T5224	T5202	advmod	well,stained
R3310	T5225	T5202	prep	for,stained
R3311	T5226	T5225	pobj	TRAP,for
R3312	T5227	T5202	cc	and,stained
R3313	T5228	T5202	conj	excavated,stained
R3314	T5229	T5230	advmod	approximately,equal
R3315	T5230	T5231	amod	equal,numbers
R3316	T5231	T5228	dobj	numbers,excavated
R3317	T5232	T5231	prep	of,numbers
R3318	T5233	T5232	pobj	pits,of
R3319	T5234	T5233	prep	of,pits
R3320	T5235	T5236	amod	equal,size
R3321	T5236	T5234	pobj	size,of
R3322	T5237	T5228	prep	in,excavated
R3323	T5238	T5239	compound	dentin,slices
R3324	T5239	T5237	pobj	slices,in
R3325	T5240	T5228	punct	", ",excavated
R3326	T5241	T5242	mark	as,visualized
R3327	T5242	T5228	advcl	visualized,excavated
R3328	T5243	T5242	prep	by,visualized
R3329	T5244	T5243	pcomp	scanning,by
R3330	T5245	T5246	compound	electron,microscopy
R3331	T5246	T5244	dobj	microscopy,scanning
R3332	T5247	T5248	punct	(,6B
R3333	T5248	T5228	parataxis	6B,excavated
R3334	T5249	T5248	compound	Figure,6B
R3335	T5250	T5248	punct	),6B
R3336	T5251	T5202	punct	.,stained
R3337	T5253	T5254	det	These,findings
R3338	T5254	T5255	nsubj	findings,suggest
R3339	T5256	T5257	mark	that,be
R3340	T5257	T5255	ccomp	be,suggest
R3341	T5258	T5259	det	the,osteoclasts
R3342	T5259	T5257	nsubj	osteoclasts,be
R3343	T5260	T5257	aux	may,be
R3344	T5261	T5257	neg	not,be
R3345	T5262	T5263	det	the,defect
R3346	T5263	T5257	attr	defect,be
R3347	T5264	T5263	amod	primary,defect
R3348	T5265	T5263	prep	in,defect
R3349	T5266	T5267	nmod	Sam68,mice
R3350	T5267	T5265	pobj	mice,in
R3351	T5268	T5266	punct	−,Sam68
R3352	T5269	T5266	punct	/,Sam68
R3353	T5270	T5266	punct	−,Sam68
R3354	T5271	T5257	punct	", ",be
R3355	T5272	T5273	mark	as,are
R3356	T5273	T5257	advcl	are,be
R3357	T5274	T5273	nsubj	they,are
R3358	T5275	T5273	prep	in,are
R3359	T5276	T5277	nmod	Src,mice
R3360	T5277	T5275	pobj	mice,in
R3361	T5278	T5277	amod	null,mice
R3362	T5279	T5280	punct	[,48
R3363	T5280	T5273	parataxis	48,are
R3364	T5281	T5280	punct	],48
R3365	T5282	T5255	punct	.,suggest
R3377	T5689	T5690	det	The,Absence
R3378	T5690	T5691	nsubj	Absence,Prevents
R3379	T5692	T5690	prep	of,Absence
R3380	T5693	T5692	pobj	Sam68,of
R3381	T5694	T5695	compound	Adipocyte,Differentiation
R3382	T5695	T5691	dobj	Differentiation,Prevents
R3383	T5696	T5691	cc	and,Prevents
R3384	T5697	T5691	conj	Promotes,Prevents
R3385	T5698	T5699	compound	Osteoblast,Differentiation
R3386	T5699	T5697	dobj	Differentiation,Promotes
R3387	T5701	T5702	nsubjpass	It,recognized
R3388	T5703	T5702	auxpass	is,recognized
R3389	T5704	T5702	advmod	well,recognized
R3390	T5705	T5706	mark	that,give
R3391	T5706	T5702	advcl	give,recognized
R3392	T5707	T5708	nmod	bone,marrow
R3393	T5708	T5709	nmod	marrow,cells
R3394	T5709	T5706	nsubj	cells,give
R3395	T5710	T5709	amod	stromal,cells
R3396	T5711	T5706	dobj	rise,give
R3397	T5712	T5706	prep	to,give
R3398	T5713	T5714	det	both,osteoblasts
R3399	T5714	T5712	pobj	osteoblasts,to
R3400	T5715	T5714	cc	and,osteoblasts
R3401	T5716	T5714	conj	adipocytes,osteoblasts
R3402	T5717	T5706	cc	and,give
R3403	T5718	T5719	mark	that,accompanied
R3404	T5719	T5706	conj	accompanied,give
R3405	T5720	T5721	npadvmod	age,related
R3406	T5721	T5723	amod	related,loss
R3407	T5722	T5721	punct	-,related
R3408	T5723	T5719	nsubjpass	loss,accompanied
R3409	T5724	T5723	compound	bone,loss
R3410	T5725	T5719	auxpass	is,accompanied
R3411	T5726	T5719	agent	by,accompanied
R3412	T5727	T5728	det	an,increase
R3413	T5728	T5726	pobj	increase,by
R3414	T5729	T5728	prep	in,increase
R3415	T5730	T5729	pobj	differentiation,in
R3416	T5731	T5719	prep	down,accompanied
R3417	T5732	T5733	det	the,lineage
R3418	T5733	T5731	pobj	lineage,down
R3419	T5734	T5733	compound	adipocyte,lineage
R3420	T5735	T5736	punct	[,22
R3421	T5736	T5719	parataxis	22,accompanied
R3422	T5737	T5736	punct	],22
R3423	T5738	T5702	punct	.,recognized
R3424	T5740	T5741	advmod	Therefore,influence
R3425	T5742	T5741	punct	", ",influence
R3426	T5743	T5744	det	the,loss
R3427	T5744	T5741	nsubj	loss,influence
R3428	T5745	T5744	prep	of,loss
R3429	T5746	T5745	pobj	Sam68,of
R3430	T5747	T5741	aux	could,influence
R3431	T5748	T5749	det	the,cells
R3432	T5749	T5741	dobj	cells,influence
R3433	T5750	T5751	nmod	bone,marrow
R3434	T5751	T5749	nmod	marrow,cells
R3435	T5752	T5749	amod	stromal,cells
R3436	T5753	T5754	aux	to,differentiate
R3437	T5754	T5741	advcl	differentiate,influence
R3438	T5755	T5754	prep	along,differentiate
R3439	T5756	T5757	det	the,osteogenic
R3440	T5757	T5755	pobj	osteogenic,along
R3441	T5758	T5757	cc	versus,osteogenic
R3442	T5759	T5760	det	the,adipogenic
R3443	T5760	T5761	nmod	adipogenic,pathway
R3444	T5761	T5757	conj	pathway,osteogenic
R3445	T5762	T5741	punct	.,influence
R3446	T5764	T5765	advmod	Alternatively,regulate
R3447	T5766	T5765	punct	", ",regulate
R3448	T5767	T5768	det	the,loss
R3449	T5768	T5765	nsubj	loss,regulate
R3450	T5769	T5768	prep	of,loss
R3451	T5770	T5769	pobj	Sam68,of
R3452	T5771	T5765	aux	could,regulate
R3453	T5772	T5765	advmod	indirectly,regulate
R3454	T5773	T5774	compound	bone,mass
R3455	T5774	T5765	dobj	mass,regulate
R3456	T5775	T5765	prep	as,regulate
R3457	T5776	T5777	det	a,disturbance
R3458	T5777	T5775	pobj	disturbance,as
R3459	T5778	T5777	amod	general,disturbance
R3460	T5779	T5777	prep	of,disturbance
R3461	T5780	T5781	amod	neuroendocrine,control
R3462	T5781	T5779	pobj	control,of
R3463	T5782	T5783	mark	as,shown
R3464	T5783	T5765	advcl	shown,regulate
R3465	T5784	T5783	auxpass	was,shown
R3466	T5785	T5786	advmod	when,shown
R3467	T5786	T5783	advcl	shown,shown
R3468	T5787	T5786	nsubjpass	leptin,shown
R3469	T5788	T5787	cc	and,leptin
R3470	T5789	T5790	det	the,axis
R3471	T5790	T5787	conj	axis,leptin
R3472	T5791	T5790	amod	sympathetic,axis
R3473	T5792	T5793	amod	nervous,system
R3474	T5793	T5790	compound	system,axis
R3475	T5794	T5786	auxpass	were,shown
R3476	T5795	T5796	aux	to,regulate
R3477	T5796	T5786	xcomp	regulate,shown
R3478	T5797	T5796	advmod	negatively,regulate
R3479	T5798	T5799	compound	bone,mass
R3480	T5799	T5796	dobj	mass,regulate
R3481	T5800	T5801	punct	[,8
R3482	T5801	T5765	parataxis	8,regulate
R3483	T5802	T5801	punct	],8
R3484	T5803	T5765	punct	.,regulate
R3485	T5805	T5806	aux	To,confirm
R3486	T5806	T5807	advcl	confirm,isolated
R3487	T5808	T5809	det	a,role
R3488	T5809	T5806	dobj	role,confirm
R3489	T5810	T5809	prep	for,role
R3490	T5811	T5810	pobj	Sam68,for
R3491	T5812	T5809	prep	in,role
R3492	T5813	T5814	det	the,regulation
R3493	T5814	T5812	pobj	regulation,in
R3494	T5815	T5814	prep	of,regulation
R3495	T5816	T5817	compound	adipocyte,differentiation
R3496	T5817	T5815	pobj	differentiation,of
R3497	T5818	T5807	punct	", ",isolated
R3498	T5819	T5807	nsubj	we,isolated
R3499	T5820	T5821	amod	primary,MEFs
R3500	T5821	T5807	dobj	MEFs,isolated
R3501	T5822	T5821	prep	from,MEFs
R3502	T5823	T5824	nummod	14.5,day
R3503	T5824	T5826	npadvmod	day,old
R3504	T5825	T5824	punct	-,day
R3505	T5826	T5828	amod	old,embryos
R3506	T5827	T5826	punct	-,old
R3507	T5828	T5822	pobj	embryos,from
R3508	T5829	T5828	nmod	Sam68,embryos
R3509	T5830	T5829	punct	+,Sam68
R3510	T5831	T5829	punct	/,Sam68
R3511	T5832	T5829	punct	+,Sam68
R3512	T5833	T5829	cc	and,Sam68
R3513	T5834	T5829	conj	Sam68,Sam68
R3514	T5835	T5834	punct	−,Sam68
R3515	T5836	T5834	punct	/,Sam68
R3516	T5837	T5834	punct	−,Sam68
R3517	T5838	T5807	punct	.,isolated
R3518	T5840	T5841	det	The,MEFs
R3519	T5841	T5847	nsubjpass	MEFs,differentiated
R3520	T5842	T5841	amod	primary,MEFs
R3521	T5843	T5841	nmod	Sam68,MEFs
R3522	T5844	T5843	punct	−,Sam68
R3523	T5845	T5843	punct	/,Sam68
R3524	T5846	T5843	punct	−,Sam68
R3525	T5848	T5847	auxpass	were,differentiated
R3526	T5849	T5847	prep	into,differentiated
R3527	T5850	T5849	pobj	adipocytes,into
R3528	T5851	T5852	advmod	in,vitro
R3529	T5852	T5847	advmod	vitro,differentiated
R3530	T5853	T5847	prep	in,differentiated
R3531	T5854	T5855	compound	culture,medium
R3532	T5855	T5853	pobj	medium,in
R3533	T5856	T5855	acl	containing,medium
R3534	T5857	T5858	nummod	5,μM
R3535	T5858	T5859	compound	μM,pioglitazone
R3536	T5859	T5856	dobj	pioglitazone,containing
R3537	T5860	T5861	aux	to,induce
R3538	T5861	T5847	advcl	induce,differentiated
R3539	T5862	T5861	dobj	adipogenesis,induce
R3540	T5863	T5847	punct	.,differentiated
R3541	T5865	T5866	nsubjpass	Cells,stained
R3542	T5867	T5865	prep	at,Cells
R3543	T5868	T5869	nmod	days,0
R3544	T5869	T5867	pobj	0,at
R3545	T5870	T5869	punct	", ",0
R3546	T5871	T5869	conj	4,0
R3547	T5872	T5871	punct	", ",4
R3548	T5873	T5871	conj	6,4
R3549	T5874	T5873	punct	", ",6
R3550	T5875	T5873	cc	and,6
R3551	T5876	T5873	conj	12,6
R3552	T5877	T5866	auxpass	were,stained
R3553	T5878	T5866	prep	with,stained
R3554	T5879	T5880	compound	Oil,O
R3555	T5880	T5878	pobj	O,with
R3556	T5881	T5880	compound	red,O
R3557	T5882	T5883	aux	to,monitor
R3558	T5883	T5866	advcl	monitor,stained
R3559	T5884	T5883	dobj	adipogenesis,monitor
R3560	T5885	T5866	punct	.,stained
R3561	T5887	T5888	nsubj	Adipogenesis,was
R3562	T5889	T5890	advmod	more,pronounced
R3563	T5890	T5888	acomp	pronounced,was
R3564	T5891	T5888	prep	in,was
R3565	T5892	T5893	det	the,cultures
R3566	T5893	T5891	pobj	cultures,in
R3567	T5894	T5895	amod	wild,type
R3568	T5895	T5893	compound	type,cultures
R3569	T5896	T5895	punct	-,type
R3570	T5897	T5893	compound	MEFs,cultures
R3571	T5898	T5888	prep	than,was
R3572	T5899	T5898	prep	in,than
R3573	T5900	T5901	det	the,MEFs
R3574	T5901	T5899	pobj	MEFs,in
R3575	T5902	T5901	nmod	Sam68,MEFs
R3576	T5903	T5902	punct	−,Sam68
R3577	T5904	T5902	punct	/,Sam68
R3578	T5905	T5902	punct	−,Sam68
R3579	T5906	T5888	punct	", ",was
R3580	T5907	T5888	advcl	consistent,was
R3581	T5908	T5907	prep	with,consistent
R3582	T5909	T5910	det	the,role
R3583	T5910	T5908	pobj	role,with
R3584	T5911	T5910	amod	positive,role
R3585	T5912	T5910	prep	of,role
R3586	T5913	T5914	amod	endogenous,Sam68
R3587	T5914	T5912	pobj	Sam68,of
R3588	T5915	T5910	prep	in,role
R3589	T5916	T5917	compound	adipocyte,differentiation
R3590	T5917	T5915	pobj	differentiation,in
R3591	T5918	T5919	punct	(,Figure
R3592	T5919	T5888	parataxis	Figure,was
R3593	T5920	T5919	nummod	7,Figure
R3594	T5921	T5919	punct	),Figure
R3595	T5922	T5888	punct	.,was
R3596	T5924	T5925	det	The,expression
R3597	T5925	T5926	nsubjpass	expression,impaired
R3598	T5927	T5925	prep	of,expression
R3599	T5928	T5929	amod	key,factors
R3600	T5929	T5927	pobj	factors,of
R3601	T5930	T5929	compound	transcription,factors
R3602	T5931	T5929	prep	including,factors
R3603	T5932	T5933	det	the,PPARγ
R3604	T5933	T5931	pobj	PPARγ,including
R3605	T5934	T5933	cc	and,PPARγ
R3606	T5935	T5933	conj	KLF5,PPARγ
R3607	T5936	T5926	auxpass	was,impaired
R3608	T5937	T5926	prep	in,impaired
R3609	T5938	T5939	nmod	Sam68,MEFs
R3610	T5939	T5937	pobj	MEFs,in
R3611	T5940	T5938	punct	−,Sam68
R3612	T5941	T5938	punct	/,Sam68
R3613	T5942	T5938	punct	−,Sam68
R3614	T5943	T5939	amod	differentiated,MEFs
R3615	T5944	T5926	prep	compared,impaired
R3616	T5945	T5944	prep	with,compared
R3617	T5946	T5947	nmod	Sam68,MEFs
R3618	T5947	T5945	pobj	MEFs,with
R3619	T5948	T5946	punct	+,Sam68
R3620	T5949	T5946	punct	/,Sam68
R3621	T5950	T5946	punct	+,Sam68
R3622	T5951	T5926	punct	", ",impaired
R3623	T5952	T5926	advcl	consistent,impaired
R3624	T5953	T5952	prep	with,consistent
R3625	T5954	T5955	amod	impaired,adipogenesis
R3626	T5955	T5953	pobj	adipogenesis,with
R3627	T5956	T5955	prep	in,adipogenesis
R3628	T5957	T5958	det	the,absence
R3629	T5958	T5956	pobj	absence,in
R3630	T5959	T5958	prep	of,absence
R3631	T5960	T5959	pobj	Sam68,of
R3632	T5961	T5962	punct	(,Figure
R3633	T5962	T5926	parataxis	Figure,impaired
R3634	T5963	T5962	nummod	7,Figure
R3635	T5964	T5962	punct	),Figure
R3636	T5965	T5926	punct	.,impaired
R3637	T5967	T5968	det	These,data
R3638	T5968	T5969	nsubj	data,support
R3639	T5970	T5968	punct	", ",data
R3640	T5971	T5968	advmod	together,data
R3641	T5972	T5971	prep	with,together
R3642	T5973	T5972	pobj	data,with
R3643	T5974	T5973	acl	confirming,data
R3644	T5975	T5976	det	a,phenotype
R3645	T5976	T5974	dobj	phenotype,confirming
R3646	T5977	T5976	amod	lean,phenotype
R3647	T5978	T5976	prep	in,phenotype
R3648	T5979	T5980	nmod	Sam68,mice
R3649	T5980	T5978	pobj	mice,in
R3650	T5981	T5979	punct	−,Sam68
R3651	T5982	T5979	punct	/,Sam68
R3652	T5983	T5979	punct	−,Sam68
R3653	T5984	T5985	punct	(,N.
R3654	T5985	T5968	meta	N.,data
R3655	T5986	T5985	nmod	Torabi,N.
R3656	T5987	T5985	cc	and,N.
R3657	T5988	T5985	conj	S.,N.
R3658	T5989	T5988	nmod	Richard,S.
R3659	T5990	T5988	punct	", ",S.
R3660	T5991	T5992	amod	unpublished,data
R3661	T5992	T5988	conj	data,S.
R3662	T5993	T5992	punct	),data
R3663	T5994	T5969	punct	", ",support
R3664	T5995	T5996	det	the,hypothesis
R3665	T5996	T5969	dobj	hypothesis,support
R3666	T5997	T5998	mark	that,modulates
R3667	T5998	T5996	acl	modulates,hypothesis
R3668	T5999	T5998	nsubj	Sam68,modulates
R3669	T6000	T6001	det	the,differentiation
R3670	T6001	T5998	dobj	differentiation,modulates
R3671	T6002	T6001	prep	of,differentiation
R3672	T6003	T6004	amod	mesenchymal,cells
R3673	T6004	T6002	pobj	cells,of
R3674	T6005	T5969	punct	.,support
R3675	T6007	T6008	aux	To,examine
R3676	T6008	T6010	advcl	examine,chose
R3677	T6009	T6008	advmod	further,examine
R3678	T6011	T6012	det	this,phenotype
R3679	T6012	T6008	dobj	phenotype,examine
R3680	T6013	T6008	prep	in,examine
R3681	T6014	T6015	det	a,system
R3682	T6015	T6013	pobj	system,in
R3683	T6016	T6017	npadvmod	cell,autonomous
R3684	T6017	T6015	amod	autonomous,system
R3685	T6018	T6010	punct	", ",chose
R3686	T6019	T6010	nsubj	we,chose
R3687	T6020	T6021	det	the,cells
R3688	T6021	T6010	dobj	cells,chose
R3689	T6022	T6021	amod	embryonic,cells
R3690	T6023	T6021	amod	mesenchymal,cells
R3691	T6024	T6021	amod	multipotential,cells
R3692	T6025	T6021	compound	progenitor,cells
R3693	T6026	T6021	appos	C3H10T1,cells
R3694	T6027	T6026	punct	/,C3H10T1
R3695	T6028	T6026	nummod	2,C3H10T1
R3696	T6029	T6010	punct	.,chose
R3697	T6031	T6032	det	The,addition
R3698	T6032	T6033	nsubj	addition,induced
R3699	T6034	T6032	prep	of,addition
R3700	T6035	T6034	pobj	BMP,of
R3701	T6036	T6035	punct	-,BMP
R3702	T6037	T6035	nummod	2,BMP
R3703	T6038	T6039	compound	osteoblast,differentiation
R3704	T6039	T6033	dobj	differentiation,induced
R3705	T6040	T6033	punct	", ",induced
R3706	T6041	T6042	mark	as,evidenced
R3707	T6042	T6033	advcl	evidenced,induced
R3708	T6043	T6042	agent	by,evidenced
R3709	T6044	T6045	det	an,increase
R3710	T6045	T6043	pobj	increase,by
R3711	T6046	T6047	advmod	approximately,400-fold
R3712	T6047	T6045	nmod	400-fold,increase
R3713	T6048	T6045	prep	in,increase
R3714	T6049	T6048	pobj	expression,in
R3715	T6050	T6049	prep	of,expression
R3716	T6051	T6052	det	the,gene
R3717	T6052	T6050	pobj	gene,of
R3718	T6053	T6052	nmod	osteocalcin,gene
R3719	T6054	T6053	punct	(,osteocalcin
R3720	T6055	T6053	appos	OCN,osteocalcin
R3721	T6056	T6052	punct	),gene
R3722	T6057	T6058	punct	[,51
R3723	T6058	T6033	parataxis	51,induced
R3724	T6059	T6058	punct	],51
R3725	T6060	T6033	punct	.,induced
R3726	T6062	T6063	nsubjpass	Populations,selected
R3727	T6064	T6062	prep	of,Populations
R3728	T6065	T6066	nmod	C3H10T1,cells
R3729	T6066	T6064	pobj	cells,of
R3730	T6067	T6065	punct	/,C3H10T1
R3731	T6068	T6065	nummod	2,C3H10T1
R3732	T6069	T6070	advmod	stably,transfected
R3733	T6070	T6062	acl	transfected,Populations
R3734	T6071	T6070	prep	with,transfected
R3735	T6072	T6073	preconj	either,retro
R3736	T6073	T6071	pobj	retro,with
R3737	T6074	T6073	compound	pSuper,retro
R3738	T6075	T6073	punct	-,retro
R3739	T6076	T6077	punct	(,control
R3740	T6077	T6073	parataxis	control,retro
R3741	T6078	T6077	punct	),control
R3742	T6079	T6073	cc	and,retro
R3743	T6080	T6081	compound	pSuper,retro
R3744	T6081	T6073	conj	retro,retro
R3745	T6082	T6081	punct	-,retro
R3746	T6083	T6081	acl	harboring,retro
R3747	T6084	T6085	det	a,hairpin
R3748	T6085	T6083	dobj	hairpin,harboring
R3749	T6086	T6085	amod	short,hairpin
R3750	T6087	T6085	prep	against,hairpin
R3751	T6088	T6087	pobj	Sam68,against
R3752	T6089	T6085	punct	(,hairpin
R3753	T6090	T6085	appos	Sam68sh,hairpin
R3754	T6091	T6063	punct	),selected
R3755	T6092	T6063	auxpass	were,selected
R3756	T6093	T6063	prep	with,selected
R3757	T6094	T6093	pobj	puromycin,with
R3758	T6095	T6063	punct	.,selected
R3759	T6097	T6098	det	The,expression
R3760	T6098	T6099	nsubjpass	expression,reduced
R3761	T6100	T6098	prep	of,expression
R3762	T6101	T6100	pobj	Sam68,of
R3763	T6102	T6099	auxpass	was,reduced
R3764	T6103	T6099	prep	by,reduced
R3765	T6104	T6105	advmod	approximately,80
R3766	T6105	T6106	nummod	80,%
R3767	T6106	T6103	pobj	%,by
R3768	T6107	T6108	mark	as,evidenced
R3769	T6108	T6099	advcl	evidenced,reduced
R3770	T6109	T6108	agent	by,evidenced
R3771	T6110	T6111	compound	immunoblot,analyses
R3772	T6111	T6109	pobj	analyses,by
R3773	T6112	T6111	acl	using,analyses
R3774	T6113	T6114	compound	β,actin
R3775	T6114	T6112	dobj	actin,using
R3776	T6115	T6114	punct	-,actin
R3777	T6116	T6112	prep	as,using
R3778	T6117	T6118	det	a,control
R3779	T6118	T6116	pobj	control,as
R3780	T6119	T6118	compound	loading,control
R3781	T6120	T6121	punct	(,8A
R3782	T6121	T6099	parataxis	8A,reduced
R3783	T6122	T6121	compound	Figure,8A
R3784	T6123	T6121	punct	),8A
R3785	T6124	T6099	punct	.,reduced
R3786	T6126	T6127	compound	Osteoblast,differentiation
R3787	T6127	T6128	nsubjpass	differentiation,induced
R3788	T6129	T6128	auxpass	was,induced
R3789	T6130	T6128	prep	in,induced
R3790	T6131	T6130	pobj	cultures,in
R3791	T6132	T6131	acl	expressing,cultures
R3792	T6133	T6134	compound	pSuper,retro
R3793	T6134	T6132	dobj	retro,expressing
R3794	T6135	T6134	punct	-,retro
R3795	T6136	T6134	cc	or,retro
R3796	T6137	T6138	compound	pSuper,retro
R3797	T6138	T6140	compound	retro,Sam68sh
R3798	T6139	T6138	punct	-,retro
R3799	T6140	T6134	conj	Sam68sh,retro
R3800	T6141	T6128	prep	by,induced
R3801	T6142	T6141	pobj	addition,by
R3802	T6143	T6142	prep	of,addition
R3803	T6144	T6143	pobj	BMP,of
R3804	T6145	T6144	punct	-,BMP
R3805	T6146	T6144	nummod	2,BMP
R3806	T6147	T6142	prep	to,addition
R3807	T6148	T6149	det	the,medium
R3808	T6149	T6147	pobj	medium,to
R3809	T6150	T6149	compound	culture,medium
R3810	T6151	T6128	punct	.,induced
R3811	T6152	T6128	punct	.,induced
R3812	T6154	T6155	det	The,expression
R3813	T6155	T6156	nsubjpass	expression,examined
R3814	T6157	T6155	prep	of,expression
R3815	T6158	T6157	pobj	OCN,of
R3816	T6159	T6158	cc	and,OCN
R3817	T6160	T6161	compound	β,actin
R3818	T6161	T6163	compound	actin,mRNAs
R3819	T6162	T6161	punct	-,actin
R3820	T6163	T6158	conj	mRNAs,OCN
R3821	T6164	T6156	auxpass	was,examined
R3822	T6165	T6156	prep	by,examined
R3823	T6166	T6167	amod	semiquantitative,PCR
R3824	T6167	T6165	pobj	PCR,by
R3825	T6168	T6167	compound	RT,PCR
R3826	T6169	T6167	punct	-,PCR
R3827	T6170	T6156	cc	and,examined
R3828	T6171	T6172	det	the,cells
R3829	T6172	T6176	nsubj	cells,displayed
R3830	T6173	T6174	npadvmod	Sam68sh,expressing
R3831	T6174	T6172	amod	expressing,cells
R3832	T6175	T6174	punct	-,expressing
R3833	T6176	T6156	conj	displayed,examined
R3834	T6177	T6178	det	a,phenotype
R3835	T6178	T6176	dobj	phenotype,displayed
R3836	T6179	T6180	advmod	more,pronounced
R3837	T6180	T6178	amod	pronounced,phenotype
R3838	T6181	T6178	compound	osteoblast,phenotype
R3839	T6182	T6178	prep	compared,phenotype
R3840	T6183	T6182	prep	with,compared
R3841	T6184	T6185	compound	control,cells
R3842	T6185	T6183	pobj	cells,with
R3843	T6186	T6176	punct	", ",displayed
R3844	T6187	T6188	mark	as,assessed
R3845	T6188	T6176	advcl	assessed,displayed
R3846	T6189	T6188	prep	by,assessed
R3847	T6190	T6191	det	the,expression
R3848	T6191	T6189	pobj	expression,by
R3849	T6192	T6191	prep	of,expression
R3850	T6193	T6192	pobj	OCN,of
R3851	T6194	T6195	punct	(,8B
R3852	T6195	T6176	parataxis	8B,displayed
R3853	T6196	T6195	compound	Figure,8B
R3854	T6197	T6195	punct	),8B
R3855	T6198	T6176	punct	.,displayed
R3856	T6200	T6201	prep	Given,stained
R3857	T6202	T6203	det	the,enhancement
R3858	T6203	T6200	pobj	enhancement,Given
R3859	T6204	T6203	amod	apparent,enhancement
R3860	T6205	T6203	prep	of,enhancement
R3861	T6206	T6207	amod	mineralized,nodule
R3862	T6207	T6208	compound	nodule,formation
R3863	T6208	T6205	pobj	formation,of
R3864	T6209	T6203	prep	by,enhancement
R3865	T6210	T6211	nmod	Sam68,cells
R3866	T6211	T6209	pobj	cells,by
R3867	T6212	T6210	punct	−,Sam68
R3868	T6213	T6210	punct	/,Sam68
R3869	T6214	T6210	punct	−,Sam68
R3870	T6215	T6216	nmod	bone,marrow
R3871	T6216	T6211	nmod	marrow,cells
R3872	T6217	T6211	amod	stromal,cells
R3873	T6218	T6219	advmod	ex,vivo
R3874	T6219	T6203	advmod	vivo,enhancement
R3875	T6220	T6203	cc	and,enhancement
R3876	T6221	T6222	det	the,phenotype
R3877	T6222	T6203	conj	phenotype,enhancement
R3878	T6223	T6222	acl	observed,phenotype
R3879	T6224	T6223	prep	with,observed
R3880	T6225	T6226	amod	short,RNA
R3881	T6226	T6228	npadvmod	RNA,treated
R3882	T6227	T6226	compound	hairpin,RNA
R3883	T6228	T6233	amod	treated,C3H10T1
R3884	T6229	T6226	punct	(,RNA
R3885	T6230	T6226	appos	shRNA,RNA
R3886	T6231	T6228	punct	),treated
R3887	T6232	T6228	punct	-,treated
R3888	T6233	T6224	pobj	C3H10T1,with
R3889	T6234	T6233	punct	/,C3H10T1
R3890	T6235	T6233	nummod	2,C3H10T1
R3891	T6236	T6201	punct	", ",stained
R3892	T6237	T6201	nsubj	we,stained
R3893	T6238	T6201	dobj	sections,stained
R3894	T6239	T6238	prep	of,sections
R3895	T6240	T6239	pobj	bone,of
R3896	T6241	T6238	prep	from,sections
R3897	T6242	T6243	nummod	4,month
R3898	T6243	T6248	npadvmod	month,old
R3899	T6244	T6242	punct	-,4
R3900	T6245	T6242	cc	and,4
R3901	T6246	T6242	conj	12,4
R3902	T6247	T6243	punct	-,month
R3903	T6248	T6250	amod	old,mice
R3904	T6249	T6248	punct	-,old
R3905	T6250	T6241	pobj	mice,from
R3906	T6251	T6201	prep	for,stained
R3907	T6252	T6251	pobj	evidence,for
R3908	T6253	T6252	prep	of,evidence
R3909	T6254	T6253	pobj	changes,of
R3910	T6255	T6254	prep	in,changes
R3911	T6256	T6257	compound	marrow,adiposity
R3912	T6257	T6255	pobj	adiposity,in
R3913	T6258	T6201	punct	.,stained
R3914	T6260	T6261	nsubj	Figure,shows
R3915	T6262	T6260	nummod	9,Figure
R3916	T6263	T6261	dobj	sections,shows
R3917	T6264	T6263	prep	of,sections
R3918	T6265	T6266	amod	undecalcified,bone
R3919	T6266	T6264	pobj	bone,of
R3920	T6267	T6266	prep	from,bone
R3921	T6268	T6269	nummod	4,month
R3922	T6269	T6274	npadvmod	month,old
R3923	T6270	T6268	punct	-,4
R3924	T6271	T6268	cc	and,4
R3925	T6272	T6268	conj	12,4
R3926	T6273	T6269	punct	-,month
R3927	T6274	T6276	amod	old,mice
R3928	T6275	T6274	punct	-,old
R3929	T6276	T6267	pobj	mice,from
R3930	T6277	T6276	nmod	Sam68,mice
R3931	T6278	T6277	punct	+,Sam68
R3932	T6279	T6277	punct	/,Sam68
R3933	T6280	T6277	punct	+,Sam68
R3934	T6281	T6277	cc	and,Sam68
R3935	T6282	T6277	conj	Sam68,Sam68
R3936	T6283	T6282	punct	−,Sam68
R3937	T6284	T6282	punct	/,Sam68
R3938	T6285	T6282	punct	−,Sam68
R3939	T6286	T6276	acl	stained,mice
R3940	T6287	T6286	prep	with,stained
R3941	T6288	T6289	compound	von,Kossa
R3942	T6289	T6287	pobj	Kossa,with
R3943	T6290	T6289	cc	and,Kossa
R3944	T6291	T6289	conj	toluidine,Kossa
R3945	T6292	T6291	amod	blue,toluidine
R3946	T6293	T6294	aux	to,show
R3947	T6294	T6286	advcl	show,stained
R3948	T6295	T6296	amod	mineralized,tissue
R3949	T6296	T6294	dobj	tissue,show
R3950	T6297	T6298	punct	(,9A
R3951	T6298	T6296	parataxis	9A,tissue
R3952	T6299	T6298	compound	Figure,9A
R3953	T6300	T6298	punct	", ",9A
R3954	T6301	T6298	amod	black,9A
R3955	T6302	T6298	punct	),9A
R3956	T6303	T6296	cc	and,tissue
R3957	T6304	T6305	compound	marrow,adipocytes
R3958	T6305	T6296	conj	adipocytes,tissue
R3959	T6306	T6307	punct	(,9B
R3960	T6307	T6305	parataxis	9B,adipocytes
R3961	T6308	T6307	compound	Figure,9B
R3962	T6309	T6307	punct	", ",9B
R3963	T6310	T6307	amod	white,9B
R3964	T6311	T6307	punct	),9B
R3965	T6312	T6286	cc	and,stained
R3966	T6313	T6286	conj	left,stained
R3967	T6314	T6313	oprd	unstained,left
R3968	T6315	T6316	aux	to,show
R3969	T6316	T6313	advcl	show,left
R3970	T6317	T6318	compound	fluorochrome,labeling
R3971	T6318	T6316	dobj	labeling,show
R3972	T6319	T6318	prep	of,labeling
R3973	T6320	T6321	det	the,fronts
R3974	T6321	T6319	pobj	fronts,of
R3975	T6322	T6321	compound	mineralization,fronts
R3976	T6323	T6324	punct	(,9C
R3977	T6324	T6316	parataxis	9C,show
R3978	T6325	T6324	compound	Figure,9C
R3979	T6326	T6324	punct	),9C
R3980	T6327	T6261	punct	.,shows
R3981	T6329	T6330	nummod	Twelve,month
R3982	T6330	T6332	npadvmod	month,old
R3983	T6331	T6330	punct	-,month
R3984	T6332	T6334	amod	old,mice
R3985	T6333	T6332	punct	-,old
R3986	T6334	T6339	nsubj	mice,showed
R3987	T6335	T6334	nmod	Sam68,mice
R3988	T6336	T6335	punct	+,Sam68
R3989	T6337	T6335	punct	/,Sam68
R3990	T6338	T6335	punct	+,Sam68
R3991	T6340	T6341	det	a,decrease
R3992	T6341	T6339	dobj	decrease,showed
R3993	T6342	T6341	amod	noticeable,decrease
R3994	T6343	T6341	prep	in,decrease
R3995	T6344	T6345	amod	trabecular,bone
R3996	T6345	T6343	pobj	bone,in
R3997	T6346	T6347	punct	(,9A
R3998	T6347	T6345	parataxis	9A,bone
R3999	T6348	T6347	compound	Figure,9A
R4000	T6349	T6347	punct	),9A
R4001	T6350	T6341	punct	", ",decrease
R4002	T6351	T6352	dep	which,associated
R4003	T6352	T6341	relcl	associated,decrease
R4004	T6353	T6352	auxpass	was,associated
R4005	T6354	T6352	prep	with,associated
R4006	T6355	T6356	det	a,increase
R4007	T6356	T6354	pobj	increase,with
R4008	T6357	T6356	amod	significant,increase
R4009	T6358	T6356	prep	in,increase
R4010	T6359	T6360	compound	marrow,adiposity
R4011	T6360	T6358	pobj	adiposity,in
R4012	T6361	T6362	punct	(,9B
R4013	T6362	T6356	parataxis	9B,increase
R4014	T6363	T6362	compound	Figure,9B
R4015	T6364	T6362	punct	),9B
R4016	T6365	T6354	cc	and,with
R4017	T6366	T6354	conj	with,with
R4018	T6367	T6368	det	the,labels
R4019	T6368	T6366	pobj	labels,with
R4020	T6369	T6368	nummod	two,labels
R4021	T6370	T6368	compound	fluorochrome,labels
R4022	T6371	T6368	acl	superimposed,labels
R4023	T6372	T6371	prep	upon,superimposed
R4024	T6373	T6372	pobj	one,upon
R4025	T6374	T6373	det	another,one
R4026	T6375	T6376	punct	(,9C
R4027	T6376	T6368	parataxis	9C,labels
R4028	T6377	T6376	compound	Figure,9C
R4029	T6378	T6376	punct	),9C
R4030	T6379	T6339	punct	.,showed
R4031	T6381	T6382	prep	In,appeared
R4032	T6383	T6381	pobj	contrast,In
R4033	T6384	T6382	punct	", ",appeared
R4034	T6385	T6386	det	the,bones
R4035	T6386	T6382	nsubj	bones,appeared
R4036	T6387	T6386	prep	of,bones
R4037	T6388	T6389	nummod	12,month
R4038	T6389	T6391	npadvmod	month,old
R4039	T6390	T6389	punct	-,month
R4040	T6391	T6393	amod	old,mice
R4041	T6392	T6391	punct	-,old
R4042	T6393	T6387	pobj	mice,of
R4043	T6394	T6393	nmod	Sam68,mice
R4044	T6395	T6394	punct	−,Sam68
R4045	T6396	T6394	punct	/,Sam68
R4046	T6397	T6394	punct	−,Sam68
R4047	T6398	T6382	oprd	similar,appeared
R4048	T6399	T6398	prep	to,similar
R4049	T6400	T6399	pobj	those,to
R4050	T6401	T6400	prep	of,those
R4051	T6402	T6403	det	the,mice
R4052	T6403	T6401	pobj	mice,of
R4053	T6404	T6405	nummod	4,month
R4054	T6405	T6407	npadvmod	month,old
R4055	T6406	T6405	punct	-,month
R4056	T6407	T6403	amod	old,mice
R4057	T6408	T6407	punct	-,old
R4058	T6409	T6403	prep	of,mice
R4059	T6410	T6411	det	either,genotype
R4060	T6411	T6409	pobj	genotype,of
R4061	T6412	T6382	punct	.,appeared
R4062	T6414	T6415	det	These,data
R4063	T6415	T6416	nsubj	data,demonstrate
R4064	T6417	T6418	mark	that,regulates
R4065	T6418	T6416	ccomp	regulates,demonstrate
R4066	T6419	T6418	nsubj	Sam68,regulates
R4067	T6420	T6421	det	the,differentiation
R4068	T6421	T6418	dobj	differentiation,regulates
R4069	T6422	T6421	prep	of,differentiation
R4070	T6423	T6424	nmod	bone,marrow
R4071	T6424	T6425	nmod	marrow,cells
R4072	T6425	T6422	pobj	cells,of
R4073	T6426	T6425	amod	mesenchymal,cells
R4074	T6427	T6428	aux	to,promote
R4075	T6428	T6418	advcl	promote,regulates
R4076	T6429	T6430	compound	adipocyte,differentiation
R4077	T6430	T6428	dobj	differentiation,promote
R4078	T6431	T6428	cc	and,promote
R4079	T6432	T6428	conj	inhibit,promote
R4080	T6433	T6434	compound	osteoblast,differentiation
R4081	T6434	T6432	dobj	differentiation,inhibit
R4082	T6435	T6428	prep	in,promote
R4083	T6436	T6437	amod	aging,bone
R4084	T6437	T6435	pobj	bone,in
R4085	T6438	T6416	punct	.,demonstrate
R4104	T7333	T7334	det	The,study
R4105	T7334	T7336	nsubj	study,provides
R4106	T7335	T7334	amod	present,study
R4107	T7337	T7336	dobj	evidence,provides
R4108	T7338	T7339	mark	that,is
R4109	T7339	T7337	acl	is,evidence
R4110	T7340	T7341	det	a,role
R4111	T7341	T7339	nsubj	role,is
R4112	T7342	T7341	amod	physiologic,role
R4113	T7343	T7341	prep	of,role
R4114	T7344	T7343	pobj	Sam68,of
R4115	T7345	T7346	aux	to,modulate
R4116	T7346	T7339	xcomp	modulate,is
R4117	T7347	T7348	nmod	bone,marrow
R4118	T7348	T7349	nmod	marrow,cells
R4119	T7349	T7346	dobj	cells,modulate
R4120	T7350	T7349	amod	mesenchymal,cells
R4121	T7351	T7349	compound	stem,cells
R4122	T7352	T7336	punct	.,provides
R4123	T7354	T7355	amod	Young,mice
R4124	T7355	T7360	nsubj	mice,developed
R4125	T7356	T7355	nmod	Sam68,mice
R4126	T7357	T7356	punct	−,Sam68
R4127	T7358	T7356	punct	/,Sam68
R4128	T7359	T7356	punct	−,Sam68
R4129	T7361	T7360	advmod	normally,developed
R4130	T7362	T7360	cc	and,developed
R4131	T7363	T7360	conj	contained,developed
R4132	T7364	T7365	amod	similar,mass
R4133	T7365	T7363	dobj	mass,contained
R4134	T7366	T7365	compound	bone,mass
R4135	T7367	T7363	prep	compared,contained
R4136	T7368	T7367	prep	with,compared
R4137	T7369	T7370	amod	wild,type
R4138	T7370	T7372	compound	type,littermates
R4139	T7371	T7370	punct	-,type
R4140	T7372	T7368	pobj	littermates,with
R4141	T7373	T7360	punct	.,developed
R4142	T7375	T7376	amod	Aged,mice
R4143	T7376	T7385	nsubj	mice,displayed
R4144	T7377	T7378	punct	(,months
R4145	T7378	T7375	parataxis	months,Aged
R4146	T7379	T7378	nummod	12,months
R4147	T7380	T7378	punct	),months
R4148	T7381	T7376	nmod	Sam68,mice
R4149	T7382	T7381	punct	−,Sam68
R4150	T7383	T7381	punct	/,Sam68
R4151	T7384	T7381	punct	−,Sam68
R4152	T7386	T7387	det	a,phenotype
R4153	T7387	T7385	dobj	phenotype,displayed
R4154	T7388	T7389	amod	high,mass
R4155	T7389	T7387	compound	mass,phenotype
R4156	T7390	T7389	compound	bone,mass
R4157	T7391	T7385	prep	compared,displayed
R4158	T7392	T7391	prep	with,compared
R4159	T7393	T7394	nmod	Sam68,littermates
R4160	T7394	T7392	pobj	littermates,with
R4161	T7395	T7393	punct	+,Sam68
R4162	T7396	T7393	punct	/,Sam68
R4163	T7397	T7393	punct	+,Sam68
R4164	T7398	T7385	punct	.,displayed
R4165	T7400	T7401	det	The,littermates
R4166	T7401	T7405	nsubj	littermates,underwent
R4167	T7402	T7403	amod	wild,type
R4168	T7403	T7401	compound	type,littermates
R4169	T7404	T7403	punct	-,type
R4170	T7406	T7407	npadvmod	age,related
R4171	T7407	T7409	amod	related,loss
R4172	T7408	T7407	punct	-,related
R4173	T7409	T7405	dobj	loss,underwent
R4174	T7410	T7409	compound	bone,loss
R4175	T7411	T7412	dep	that,occurs
R4176	T7412	T7409	relcl	occurs,loss
R4177	T7413	T7412	advmod	naturally,occurs
R4178	T7414	T7412	prep	in,occurs
R4179	T7415	T7414	pobj	mammals,in
R4180	T7416	T7405	punct	", ",underwent
R4181	T7417	T7418	mark	while,preserved
R4182	T7418	T7405	advcl	preserved,underwent
R4183	T7419	T7420	det	the,animals
R4184	T7420	T7418	nsubj	animals,preserved
R4185	T7421	T7420	nmod	Sam68,animals
R4186	T7422	T7421	punct	−,Sam68
R4187	T7423	T7421	punct	/,Sam68
R4188	T7424	T7421	punct	−,Sam68
R4189	T7425	T7426	poss	their,mass
R4190	T7426	T7418	dobj	mass,preserved
R4191	T7427	T7426	compound	bone,mass
R4192	T7428	T7418	prep	with,preserved
R4193	T7429	T7428	pobj	aging,with
R4194	T7430	T7405	punct	.,underwent
R4195	T7432	T7433	det	The,differentiation
R4196	T7433	T7434	nsubj	differentiation,resulted
R4197	T7435	T7433	prep	of,differentiation
R4198	T7436	T7437	compound	bone,marrow
R4199	T7437	T7438	compound	marrow,cells
R4200	T7438	T7435	pobj	cells,of
R4201	T7439	T7438	compound	stem,cells
R4202	T7440	T7438	acl	isolated,cells
R4203	T7441	T7440	prep	from,isolated
R4204	T7442	T7443	nmod	Sam68,mice
R4205	T7443	T7441	pobj	mice,from
R4206	T7444	T7442	punct	−,Sam68
R4207	T7445	T7442	punct	/,Sam68
R4208	T7446	T7442	punct	−,Sam68
R4209	T7447	T7438	cc	and,cells
R4210	T7448	T7449	amod	embryonic,cells
R4211	T7449	T7438	conj	cells,cells
R4212	T7450	T7449	amod	mesenchymal,cells
R4213	T7451	T7449	amod	multipotential,cells
R4214	T7452	T7449	compound	progenitor,cells
R4215	T7453	T7449	appos	C3H10T1,cells
R4216	T7454	T7453	punct	/,C3H10T1
R4217	T7455	T7453	nummod	2,C3H10T1
R4218	T7456	T7449	acl	treated,cells
R4219	T7457	T7456	prep	with,treated
R4220	T7458	T7459	compound	Sam68,shRNA
R4221	T7459	T7457	pobj	shRNA,with
R4222	T7460	T7434	prep	in,resulted
R4223	T7461	T7462	det	a,differentiation
R4224	T7462	T7460	pobj	differentiation,in
R4225	T7463	T7464	advmod	more,pronounced
R4226	T7464	T7462	amod	pronounced,differentiation
R4227	T7465	T7462	compound	osteoblast,differentiation
R4228	T7466	T7434	punct	.,resulted
R4229	T7468	T7469	det	These,findings
R4230	T7469	T7470	nsubj	findings,demonstrate
R4231	T7471	T7472	mark	that,enhances
R4232	T7472	T7470	ccomp	enhances,demonstrate
R4233	T7473	T7474	det	the,loss
R4234	T7474	T7472	nsubj	loss,enhances
R4235	T7475	T7474	prep	of,loss
R4236	T7476	T7475	pobj	Sam68,of
R4237	T7477	T7478	compound	osteoblast,differentiation
R4238	T7478	T7472	dobj	differentiation,enhances
R4239	T7479	T7470	punct	.,demonstrate
R4240	T7481	T7482	det	The,converse
R4241	T7482	T7483	nsubj	converse,was
R4242	T7484	T7483	advmod	also,was
R4243	T7485	T7483	acomp	true,was
R4244	T7486	T7483	punct	", ",was
R4245	T7487	T7488	mark	as,impaired
R4246	T7488	T7483	advcl	impaired,was
R4247	T7489	T7488	nsubjpass	MEFs,impaired
R4248	T7490	T7489	acl	isolated,MEFs
R4249	T7491	T7490	prep	from,isolated
R4250	T7492	T7493	nmod	Sam68,animals
R4251	T7493	T7491	pobj	animals,from
R4252	T7494	T7492	punct	−,Sam68
R4253	T7495	T7492	punct	/,Sam68
R4254	T7496	T7492	punct	−,Sam68
R4255	T7497	T7488	auxpass	were,impaired
R4256	T7498	T7488	prep	in,impaired
R4257	T7499	T7500	poss	their,ability
R4258	T7500	T7498	pobj	ability,in
R4259	T7501	T7502	aux	to,undergo
R4260	T7502	T7500	acl	undergo,ability
R4261	T7503	T7504	compound	adipocyte,differentiation
R4262	T7504	T7502	dobj	differentiation,undergo
R4263	T7505	T7488	prep	compared,impaired
R4264	T7506	T7505	prep	with,compared
R4265	T7507	T7508	nmod	Sam68,MEFs
R4266	T7508	T7506	pobj	MEFs,with
R4267	T7509	T7507	punct	+,Sam68
R4268	T7510	T7507	punct	/,Sam68
R4269	T7511	T7507	punct	+,Sam68
R4270	T7512	T7483	punct	.,was
R4271	T7514	T7515	det	These,findings
R4272	T7515	T7516	nsubj	findings,suggest
R4273	T7517	T7518	mark	that,is
R4274	T7518	T7516	ccomp	is,suggest
R4275	T7519	T7520	det	a,role
R4276	T7520	T7518	nsubj	role,is
R4277	T7521	T7520	amod	physiologic,role
R4278	T7522	T7520	prep	for,role
R4279	T7523	T7522	pobj	Sam68,for
R4280	T7524	T7525	aux	to,regulate
R4281	T7525	T7518	xcomp	regulate,is
R4282	T7526	T7527	det	the,balance
R4283	T7527	T7525	dobj	balance,regulate
R4284	T7528	T7527	prep	between,balance
R4285	T7529	T7530	amod	adipogenic,differentiation
R4286	T7530	T7528	pobj	differentiation,between
R4287	T7531	T7529	cc	and,adipogenic
R4288	T7532	T7529	conj	osteogenic,adipogenic
R4289	T7533	T7530	prep	of,differentiation
R4290	T7534	T7535	det	the,marrow
R4291	T7535	T7533	pobj	marrow,of
R4292	T7536	T7535	compound	bone,marrow
R4293	T7537	T7535	amod	mesenchymal,marrow
R4294	T7538	T7516	punct	.,suggest
R4295	T7540	T7541	compound	Sam68,expression
R4296	T7541	T7543	nsubjpass	expression,observed
R4297	T7542	T7541	compound	protein,expression
R4298	T7544	T7543	auxpass	was,observed
R4299	T7545	T7543	prep	throughout,observed
R4300	T7546	T7547	det	the,embryo
R4301	T7547	T7545	pobj	embryo,throughout
R4302	T7548	T7547	amod	developing,embryo
R4303	T7549	T7547	compound	mouse,embryo
R4304	T7550	T7543	punct	", ",observed
R4305	T7551	T7543	prep	in,observed
R4306	T7552	T7551	pobj	keeping,in
R4307	T7553	T7552	prep	with,keeping
R4308	T7554	T7555	amod	previous,reports
R4309	T7555	T7553	pobj	reports,with
R4310	T7556	T7557	dep	that,identified
R4311	T7557	T7555	relcl	identified,reports
R4312	T7558	T7559	det	the,mRNA
R4313	T7559	T7561	nsubjpass	mRNA,expressed
R4314	T7560	T7559	compound	Sam68,mRNA
R4315	T7561	T7557	ccomp	expressed,identified
R4316	T7562	T7561	aux	to,expressed
R4317	T7563	T7561	auxpass	be,expressed
R4318	T7564	T7561	advmod	widely,expressed
R4319	T7565	T7566	punct	[,38
R4320	T7566	T7543	parataxis	38,observed
R4321	T7567	T7566	punct	],38
R4322	T7568	T7543	punct	.,observed
R4323	T7570	T7571	nsubj	We,observe
R4324	T7572	T7573	compound	Sam68,staining
R4325	T7573	T7571	dobj	staining,observe
R4326	T7574	T7571	prep	in,observe
R4327	T7575	T7576	det	the,brain
R4328	T7576	T7574	pobj	brain,in
R4329	T7577	T7576	punct	", ",brain
R4330	T7578	T7576	conj	heart,brain
R4331	T7579	T7578	punct	", ",heart
R4332	T7580	T7578	cc	and,heart
R4333	T7581	T7578	conj	intestine,heart
R4334	T7582	T7583	punct	(,see
R4335	T7583	T7581	parataxis	see,intestine
R4336	T7584	T7583	dobj	Figure,see
R4337	T7585	T7584	nummod	1,Figure
R4338	T7586	T7583	punct	),see
R4339	T7587	T7588	advmod	as,as
R4340	T7588	T7576	cc	as,brain
R4341	T7589	T7588	advmod	well,as
R4342	T7590	T7576	conj	liver,brain
R4343	T7591	T7590	punct	", ",liver
R4344	T7592	T7590	conj	skin,liver
R4345	T7593	T7592	punct	", ",skin
R4346	T7594	T7592	cc	and,skin
R4347	T7595	T7592	conj	kidney,skin
R4348	T7596	T7597	punct	(,data
R4349	T7597	T7595	meta	data,kidney
R4350	T7598	T7597	amod	unpublished,data
R4351	T7599	T7597	punct	),data
R4352	T7600	T7576	prep	of,brain
R4353	T7601	T7602	amod	late,stage
R4354	T7602	T7604	compound	stage,embryos
R4355	T7603	T7602	punct	-,stage
R4356	T7604	T7600	pobj	embryos,of
R4357	T7605	T7571	punct	.,observe
R4358	T7607	T7608	det	This,pattern
R4359	T7608	T7610	nsubj	pattern,is
R4360	T7609	T7608	compound	expression,pattern
R4361	T7611	T7610	acomp	consistent,is
R4362	T7612	T7611	prep	with,consistent
R4363	T7613	T7614	amod	previous,work
R4364	T7614	T7612	pobj	work,with
R4365	T7615	T7616	dep	that,observed
R4366	T7616	T7614	relcl	observed,work
R4367	T7617	T7616	aux	has,observed
R4368	T7618	T7616	dobj	Sam68,observed
R4369	T7619	T7618	prep	in,Sam68
R4370	T7620	T7619	pobj	neurons,in
R4371	T7621	T7622	punct	[,52
R4372	T7622	T7619	parataxis	52,in
R4373	T7623	T7622	punct	],52
R4374	T7624	T7619	cc	and,in
R4375	T7625	T7619	conj	as,in
R4376	T7626	T7627	det	a,substrate
R4377	T7627	T7625	pobj	substrate,as
R4378	T7628	T7627	prep	of,substrate
R4379	T7629	T7630	det	the,kinase
R4380	T7630	T7628	pobj	kinase,of
R4381	T7631	T7632	amod	intestinal,SIK
R4382	T7632	T7630	nmod	SIK,kinase
R4383	T7633	T7632	punct	/,SIK
R4384	T7634	T7635	compound	breast,tumor
R4385	T7635	T7632	appos	tumor,SIK
R4386	T7636	T7637	punct	[,43
R4387	T7637	T7627	parataxis	43,substrate
R4388	T7638	T7637	punct	],43
R4389	T7639	T7610	punct	.,is
R4390	T7641	T7642	det	The,expression
R4391	T7642	T7643	nsubjpass	expression,altered
R4392	T7644	T7642	prep	of,expression
R4393	T7645	T7644	pobj	Sam68,of
R4394	T7646	T7643	auxpass	was,altered
R4395	T7647	T7643	neg	not,altered
R4396	T7648	T7643	prep	in,altered
R4397	T7649	T7650	amod	aging,cells
R4398	T7650	T7648	pobj	cells,in
R4399	T7651	T7652	nmod	bone,marrow
R4400	T7652	T7650	nmod	marrow,cells
R4401	T7653	T7650	amod	stromal,cells
R4402	T7654	T7648	cc	or,in
R4403	T7655	T7648	conj	in,in
R4404	T7656	T7657	amod	senescencing,cells
R4405	T7657	T7655	pobj	cells,in
R4406	T7658	T7657	nmod	WI,cells
R4407	T7659	T7658	punct	-,WI
R4408	T7660	T7658	nummod	38,WI
R4409	T7661	T7662	punct	(,data
R4410	T7662	T7643	meta	data,altered
R4411	T7663	T7662	amod	unpublished,data
R4412	T7664	T7662	punct	),data
R4413	T7665	T7643	punct	.,altered
R4414	T7667	T7668	det	The,presence
R4415	T7668	T7669	nsubj	presence,predicted
R4416	T7670	T7668	prep	of,presence
R4417	T7671	T7670	pobj	Sam68,of
R4418	T7672	T7668	prep	in,presence
R4419	T7673	T7672	pobj	chondrocytes,in
R4420	T7674	T7673	punct	", ",chondrocytes
R4421	T7675	T7673	conj	osteoblasts,chondrocytes
R4422	T7676	T7675	cc	and,osteoblasts
R4423	T7677	T7675	conj	osteoclasts,osteoblasts
R4424	T7678	T7673	prep	in,chondrocytes
R4425	T7679	T7680	amod	developing,cartilage
R4426	T7680	T7678	pobj	cartilage,in
R4427	T7681	T7680	cc	and,cartilage
R4428	T7682	T7680	conj	bone,cartilage
R4429	T7683	T7684	det	a,role
R4430	T7684	T7669	dobj	role,predicted
R4431	T7685	T7684	amod	pivotal,role
R4432	T7686	T7684	prep	for,role
R4433	T7687	T7688	det	the,protein
R4434	T7688	T7686	pobj	protein,for
R4435	T7689	T7684	prep	in,role
R4436	T7690	T7691	amod	skeletal,development
R4437	T7691	T7689	pobj	development,in
R4438	T7692	T7669	punct	.,predicted
R4439	T7694	T7695	det	The,mice
R4440	T7695	T7700	nsubjpass	mice,generated
R4441	T7696	T7695	nmod	Sam68,mice
R4442	T7697	T7696	punct	−,Sam68
R4443	T7698	T7696	punct	/,Sam68
R4444	T7699	T7696	punct	−,Sam68
R4445	T7701	T7700	auxpass	were,generated
R4446	T7702	T7700	advcl	using,generated
R4447	T7703	T7704	det	a,approach
R4448	T7704	T7702	dobj	approach,using
R4449	T7705	T7704	amod	traditional,approach
R4450	T7706	T7704	compound	targeting,approach
R4451	T7707	T7708	advmod	where,deleted
R4452	T7708	T7704	relcl	deleted,approach
R4453	T7709	T7710	det	the,domain
R4454	T7710	T7708	nsubjpass	domain,deleted
R4455	T7711	T7710	amod	functional,domain
R4456	T7712	T7710	compound	KH,domain
R4457	T7713	T7708	auxpass	was,deleted
R4458	T7714	T7700	cc	and,generated
R4459	T7715	T7716	advmod	approximately,one
R4460	T7716	T7717	nsubj	one,survived
R4461	T7717	T7700	conj	survived,generated
R4462	T7718	T7716	amod	third,one
R4463	T7719	T7716	prep	of,one
R4464	T7720	T7721	det	the,mice
R4465	T7721	T7719	pobj	mice,of
R4466	T7722	T7721	nmod	Sam68,mice
R4467	T7723	T7722	punct	−,Sam68
R4468	T7724	T7722	punct	/,Sam68
R4469	T7725	T7722	punct	−,Sam68
R4470	T7726	T7717	prep	to,survived
R4471	T7727	T7726	pobj	adulthood,to
R4472	T7728	T7717	prep	with,survived
R4473	T7729	T7730	det	no,defects
R4474	T7730	T7728	pobj	defects,with
R4475	T7731	T7730	amod	apparent,defects
R4476	T7732	T7717	punct	.,survived
R4477	T7734	T7735	nummod	One,explanation
R4478	T7735	T7736	nsubj	explanation,is
R4479	T7737	T7735	prep	for,explanation
R4480	T7738	T7739	det	this,phenomenon
R4481	T7739	T7737	pobj	phenomenon,for
R4482	T7740	T7741	mark	that,sub-served
R4483	T7741	T7736	ccomp	sub-served,is
R4484	T7742	T7743	compound	Sam68,function
R4485	T7743	T7741	nsubjpass	function,sub-served
R4486	T7744	T7741	auxpass	is,sub-served
R4487	T7745	T7741	agent	by,sub-served
R4488	T7746	T7745	pobj	one,by
R4489	T7747	T7746	cc	or,one
R4490	T7748	T7746	conj	more,one
R4491	T7749	T7746	prep	of,one
R4492	T7750	T7751	poss	its,members
R4493	T7751	T7749	pobj	members,of
R4494	T7752	T7751	compound	family,members
R4495	T7753	T7741	prep	during,sub-served
R4496	T7754	T7753	pobj	development,during
R4497	T7755	T7756	amod	such,as
R4498	T7756	T7741	prep	as,sub-served
R4499	T7757	T7756	pobj	SLM,as
R4500	T7758	T7757	punct	-,SLM
R4501	T7759	T7757	nummod	1,SLM
R4502	T7760	T7757	cc	and,SLM
R4503	T7761	T7757	conj	SLM,SLM
R4504	T7762	T7761	punct	-,SLM
R4505	T7763	T7761	nummod	2,SLM
R4506	T7764	T7765	punct	[,47
R4507	T7765	T7736	parataxis	47,is
R4508	T7766	T7765	punct	],47
R4509	T7767	T7736	punct	.,is
R4510	T7769	T7770	advmod	Alternatively,required
R4511	T7771	T7770	punct	", ",required
R4512	T7772	T7770	nsubjpass	Sam68,required
R4513	T7773	T7770	auxpass	is,required
R4514	T7774	T7770	neg	not,required
R4515	T7775	T7770	prep	during,required
R4516	T7776	T7777	amod	embryonic,development
R4517	T7777	T7775	pobj	development,during
R4518	T7778	T7770	punct	.,required
R4519	T7780	T7781	advmod	However,killed
R4520	T7782	T7781	punct	", ",killed
R4521	T7783	T7784	nummod	two,thirds
R4522	T7784	T7781	nsubjpass	thirds,killed
R4523	T7785	T7784	prep	of,thirds
R4524	T7786	T7787	det	the,Sam68
R4525	T7787	T7785	pobj	Sam68,of
R4526	T7788	T7787	punct	−,Sam68
R4527	T7789	T7787	punct	/,Sam68
R4528	T7790	T7787	punct	−,Sam68
R4529	T7791	T7787	punct	", ",Sam68
R4530	T7792	T7787	cc	but,Sam68
R4531	T7793	T7792	neg	not,but
R4532	T7794	T7795	det	the,Sam68
R4533	T7795	T7796	nmod	Sam68,pups
R4534	T7796	T7787	conj	pups,Sam68
R4535	T7797	T7795	punct	+,Sam68
R4536	T7798	T7795	punct	/,Sam68
R4537	T7799	T7795	punct	-,Sam68
R4538	T7800	T7781	punct	", ",killed
R4539	T7801	T7781	auxpass	were,killed
R4540	T7802	T7781	agent	by,killed
R4541	T7803	T7804	poss	their,mothers
R4542	T7804	T7802	pobj	mothers,by
R4543	T7805	T7804	nmod	Sam68,mothers
R4544	T7806	T7805	punct	+,Sam68
R4545	T7807	T7805	punct	/,Sam68
R4546	T7808	T7805	punct	-,Sam68
R4547	T7809	T7781	punct	.,killed
R4548	T7811	T7812	det	These,findings
R4549	T7812	T7813	nsubj	findings,suggest
R4550	T7814	T7815	mark	that,are
R4551	T7815	T7813	ccomp	are,suggest
R4552	T7816	T7817	det	the,mothers
R4553	T7817	T7815	nsubj	mothers,are
R4554	T7818	T7815	acomp	able,are
R4555	T7819	T7820	aux	to,detect
R4556	T7820	T7818	xcomp	detect,able
R4557	T7821	T7822	det	a,difference
R4558	T7822	T7820	dobj	difference,detect
R4559	T7823	T7822	amod	subtle,difference
R4560	T7824	T7822	compound	defect,difference
R4561	T7825	T7822	punct	/,difference
R4562	T7826	T7827	dep	that,can
R4563	T7827	T7822	relcl	can,difference
R4564	T7828	T7827	nsubj	we,can
R4565	T7829	T7827	neg	not,can
R4566	T7830	T7813	punct	.,suggest
R4567	T7832	T7833	amod	Adult,mice
R4568	T7833	T7838	nsubj	mice,live
R4569	T7834	T7833	nmod	Sam68,mice
R4570	T7835	T7834	punct	−,Sam68
R4571	T7836	T7834	punct	/,Sam68
R4572	T7837	T7834	punct	−,Sam68
R4573	T7839	T7840	det	a,span
R4574	T7840	T7838	dobj	span,live
R4575	T7841	T7840	amod	normal,span
R4576	T7842	T7840	compound	life,span
R4577	T7843	T7840	prep	of,span
R4578	T7844	T7845	advmod	approximately,two
R4579	T7845	T7846	nummod	two,years
R4580	T7846	T7843	pobj	years,of
R4581	T7847	T7838	punct	.,live
R4582	T7849	T7850	det	The,males
R4583	T7850	T7855	nsubj	males,were
R4584	T7851	T7850	nmod	Sam68,males
R4585	T7852	T7851	punct	−,Sam68
R4586	T7853	T7851	punct	/,Sam68
R4587	T7854	T7851	punct	−,Sam68
R4588	T7856	T7855	acomp	sterile,were
R4589	T7857	T7855	cc	and,were
R4590	T7858	T7859	det	the,females
R4591	T7859	T7864	nsubj	females,provided
R4592	T7860	T7859	nmod	Sam68,females
R4593	T7861	T7860	punct	−,Sam68
R4594	T7862	T7860	punct	/,Sam68
R4595	T7863	T7860	punct	−,Sam68
R4596	T7864	T7855	conj	provided,were
R4597	T7865	T7866	amod	inadequate,care
R4598	T7866	T7864	dobj	care,provided
R4599	T7867	T7864	dative	to,provided
R4600	T7868	T7869	poss	their,young
R4601	T7869	T7867	pobj	young,to
R4602	T7870	T7855	punct	", ",were
R4603	T7871	T7855	cc	but,were
R4604	T7872	T7873	det	the,pups
R4605	T7873	T7874	nsubjpass	pups,scattered
R4606	T7874	T7855	conj	scattered,were
R4607	T7875	T7874	auxpass	were,scattered
R4608	T7876	T7874	neg	not,scattered
R4609	T7877	T7874	cc	and,scattered
R4610	T7878	T7874	conj	neglected,scattered
R4611	T7879	T7880	mark	as,observed
R4612	T7880	T7878	advcl	observed,neglected
R4613	T7881	T7880	prep	with,observed
R4614	T7882	T7883	nmod	FosB,mice
R4615	T7883	T7881	pobj	mice,with
R4616	T7884	T7882	punct	−,FosB
R4617	T7885	T7882	punct	/,FosB
R4618	T7886	T7882	punct	−,FosB
R4619	T7887	T7888	punct	[,53
R4620	T7888	T7878	parataxis	53,neglected
R4621	T7889	T7888	punct	],53
R4622	T7890	T7874	punct	.,scattered
R4623	T7892	T7893	compound	Serum,levels
R4624	T7893	T7894	nsubj	levels,decreased
R4625	T7894	T7897	ccomp	decreased,decreased
R4626	T7895	T7893	prep	of,levels
R4627	T7896	T7895	pobj	estrogen,of
R4628	T7898	T7894	prep	in,decreased
R4629	T7899	T7900	amod	aging,females
R4630	T7900	T7898	pobj	females,in
R4631	T7901	T7900	nmod	Sam68,females
R4632	T7902	T7901	punct	−,Sam68
R4633	T7903	T7901	punct	/,Sam68
R4634	T7904	T7901	punct	−,Sam68
R4635	T7905	T7906	mark	as,expected
R4636	T7906	T7894	advcl	expected,decreased
R4637	T7907	T7897	punct	;,decreased
R4638	T7908	T7897	advmod	however,decreased
R4639	T7909	T7897	punct	", ",decreased
R4640	T7910	T7911	det	the,levels
R4641	T7911	T7897	nsubj	levels,decreased
R4642	T7912	T7911	compound	leptin,levels
R4643	T7913	T7897	prep	in,decreased
R4644	T7914	T7915	amod	aged,females
R4645	T7915	T7913	pobj	females,in
R4646	T7916	T7915	nmod	Sam68,females
R4647	T7917	T7916	punct	−,Sam68
R4648	T7918	T7916	punct	/,Sam68
R4649	T7919	T7916	punct	−,Sam68
R4650	T7920	T7897	punct	.,decreased
R4651	T7922	T7923	det	The,females
R4652	T7923	T7929	nsubj	females,were
R4653	T7924	T7923	amod	aged,females
R4654	T7925	T7923	nmod	Sam68,females
R4655	T7926	T7925	punct	−,Sam68
R4656	T7927	T7925	punct	/,Sam68
R4657	T7928	T7925	punct	−,Sam68
R4658	T7930	T7929	neg	not,were
R4659	T7931	T7929	acomp	obese,were
R4660	T7932	T7929	cc	and,were
R4661	T7933	T7934	advmod	actually,weighed
R4662	T7934	T7929	conj	weighed,were
R4663	T7935	T7934	dobj	less,weighed
R4664	T7936	T7935	prep	than,less
R4665	T7937	T7938	det	the,controls
R4666	T7938	T7936	pobj	controls,than
R4667	T7939	T7938	compound	littermate,controls
R4668	T7940	T7941	punct	(,see
R4669	T7941	T7934	parataxis	see,weighed
R4670	T7942	T7941	dobj	Table,see
R4671	T7943	T7942	nummod	2,Table
R4672	T7944	T7941	punct	),see
R4673	T7945	T7929	punct	.,were
R4674	T7947	T7948	advmod	Moreover,altered
R4675	T7949	T7948	punct	", ",altered
R4676	T7950	T7951	poss	their,appetite
R4677	T7951	T7948	nsubjpass	appetite,altered
R4678	T7952	T7948	auxpass	was,altered
R4679	T7953	T7948	neg	not,altered
R4680	T7954	T7948	prep	with,altered
R4681	T7955	T7954	pobj	aging,with
R4682	T7956	T7957	punct	(,N.
R4683	T7957	T7948	meta	N.,altered
R4684	T7958	T7957	nmod	Torabi,N.
R4685	T7959	T7957	cc	and,N.
R4686	T7960	T7957	conj	S.,N.
R4687	T7961	T7960	nmod	Richard,S.
R4688	T7962	T7960	punct	", ",S.
R4689	T7963	T7964	amod	unpublished,data
R4690	T7964	T7960	conj	data,S.
R4691	T7965	T7964	punct	),data
R4692	T7966	T7948	punct	", ",altered
R4693	T7967	T7948	advcl	suggesting,altered
R4694	T7968	T7969	mark	that,recreating
R4695	T7969	T7967	ccomp	recreating,suggesting
R4696	T7970	T7971	det	the,reduction
R4697	T7971	T7969	nsubj	reduction,recreating
R4698	T7972	T7971	amod	observed,reduction
R4699	T7973	T7971	compound	leptin,reduction
R4700	T7974	T7969	aux	was,recreating
R4701	T7975	T7969	neg	not,recreating
R4702	T7976	T7977	dep	ob,like
R4703	T7977	T7981	amod	like,phenotypes
R4704	T7978	T7977	punct	/,like
R4705	T7979	T7977	npadvmod	ob,like
R4706	T7980	T7977	punct	-,like
R4707	T7981	T7969	dobj	phenotypes,recreating
R4708	T7982	T7981	acl	related,phenotypes
R4709	T7983	T7982	prep	to,related
R4710	T7984	T7983	pobj	weight,to
R4711	T7985	T7984	punct	", ",weight
R4712	T7986	T7984	conj	appetite,weight
R4713	T7987	T7986	cc	and,appetite
R4714	T7988	T7989	amod	female,sterility
R4715	T7989	T7986	conj	sterility,appetite
R4716	T7990	T7991	punct	[,54
R4717	T7991	T7948	parataxis	54,altered
R4718	T7992	T7991	punct	],54
R4719	T7993	T7948	punct	.,altered
R4720	T7995	T7996	det	The,phenotyping
R4721	T7996	T7998	nsubj	phenotyping,showed
R4722	T7997	T7996	amod	skeletal,phenotyping
R4723	T7999	T7996	prep	of,phenotyping
R4724	T8000	T7999	pobj	cohorts,of
R4725	T8001	T8000	prep	of,cohorts
R4726	T8002	T8003	nmod	Sam68,mice
R4727	T8003	T8001	pobj	mice,of
R4728	T8004	T8002	punct	+,Sam68
R4729	T8005	T8002	punct	/,Sam68
R4730	T8006	T8002	punct	+,Sam68
R4731	T8007	T8002	cc	and,Sam68
R4732	T8008	T8002	conj	Sam68,Sam68
R4733	T8009	T8008	punct	−,Sam68
R4734	T8010	T8008	punct	/,Sam68
R4735	T8011	T8008	punct	−,Sam68
R4736	T8012	T8013	mark	that,preserved
R4737	T8013	T7998	ccomp	preserved,showed
R4738	T8014	T8015	compound	bone,mass
R4739	T8015	T8013	nsubjpass	mass,preserved
R4740	T8016	T8013	auxpass	was,preserved
R4741	T8017	T8013	prep	in,preserved
R4742	T8018	T8019	amod	aged,mice
R4743	T8019	T8017	pobj	mice,in
R4744	T8020	T8019	nmod	Sam68,mice
R4745	T8021	T8020	punct	−,Sam68
R4746	T8022	T8020	punct	/,Sam68
R4747	T8023	T8020	punct	−,Sam68
R4748	T8024	T7998	punct	.,showed
R4749	T8026	T8027	amod	Traditional,histology
R4750	T8027	T8028	nsubj	histology,suggested
R4751	T8029	T8027	cc	and,histology
R4752	T8030	T8027	conj	histomorphometry,histology
R4753	T8031	T8032	mark	that,involved
R4754	T8032	T8028	ccomp	involved,suggested
R4755	T8033	T8034	det	the,mechanism
R4756	T8034	T8032	nsubj	mechanism,involved
R4757	T8035	T8032	dobj	preservation,involved
R4758	T8036	T8035	prep	of,preservation
R4759	T8037	T8038	nmod	osteoblast,activity
R4760	T8038	T8036	pobj	activity,of
R4761	T8039	T8037	cc	and,osteoblast
R4762	T8040	T8037	conj	osteoclast,osteoblast
R4763	T8041	T8028	dep	.,suggested
R4764	T8043	T8044	det	The,role
R4765	T8044	T8046	nsubj	role,led
R4766	T8045	T8044	amod	documented,role
R4767	T8047	T8044	prep	of,role
R4768	T8048	T8049	det	the,protein
R4769	T8049	T8047	pobj	protein,of
R4770	T8050	T8049	nmod	Sam68,protein
R4771	T8051	T8049	amod	regulatory,protein
R4772	T8052	T8049	punct	", ",protein
R4773	T8053	T8049	appos	Src,protein
R4774	T8054	T8044	punct	", ",role
R4775	T8055	T8044	prep	in,role
R4776	T8056	T8055	pobj	osteopetrosis,in
R4777	T8057	T8046	dobj	us,led
R4778	T8058	T8059	aux	to,investigate
R4779	T8059	T8046	xcomp	investigate,led
R4780	T8060	T8061	det	the,morphology
R4781	T8061	T8059	dobj	morphology,investigate
R4782	T8062	T8061	cc	and,morphology
R4783	T8063	T8061	conj	activity,morphology
R4784	T8064	T8061	prep	of,morphology
R4785	T8065	T8066	nmod	Sam68,osteoclasts
R4786	T8066	T8064	pobj	osteoclasts,of
R4787	T8067	T8065	punct	−,Sam68
R4788	T8068	T8065	punct	/,Sam68
R4789	T8069	T8065	punct	−,Sam68
R4790	T8070	T8071	advmod	ex,vivo
R4791	T8071	T8059	advmod	vivo,investigate
R4792	T8072	T8046	punct	.,led
R4793	T8074	T8075	det	The,kinase
R4794	T8075	T8078	nsubjpass	kinase,shown
R4795	T8076	T8075	compound	Src,kinase
R4796	T8077	T8075	compound	tyrosine,kinase
R4797	T8079	T8078	auxpass	was,shown
R4798	T8080	T8081	aux	to,play
R4799	T8081	T8078	xcomp	play,shown
R4800	T8082	T8083	det	a,role
R4801	T8083	T8081	dobj	role,play
R4802	T8084	T8081	prep	in,play
R4803	T8085	T8086	compound	bone,remodeling
R4804	T8086	T8084	pobj	remodeling,in
R4805	T8087	T8088	advmod	when,died
R4806	T8088	T8081	advcl	died,play
R4807	T8089	T8090	nmod	Src,mice
R4808	T8090	T8088	nsubj	mice,died
R4809	T8091	T8089	punct	−,Src
R4810	T8092	T8089	punct	/,Src
R4811	T8093	T8089	punct	−,Src
R4812	T8094	T8088	prep	at,died
R4813	T8095	T8096	nummod	6,months
R4814	T8096	T8094	pobj	months,at
R4815	T8097	T8096	prep	of,months
R4816	T8098	T8097	pobj	age,of
R4817	T8099	T8088	prep	with,died
R4818	T8100	T8101	det	an,phenotype
R4819	T8101	T8099	pobj	phenotype,with
R4820	T8102	T8101	amod	osteopetrotic,phenotype
R4821	T8103	T8104	punct	[,48
R4822	T8104	T8088	parataxis	48,died
R4823	T8105	T8104	punct	],48
R4824	T8106	T8088	cc	and,died
R4825	T8107	T8108	det	the,defect
R4826	T8108	T8109	nsubjpass	defect,attributed
R4827	T8109	T8088	conj	attributed,died
R4828	T8110	T8109	auxpass	was,attributed
R4829	T8111	T8109	prep	to,attributed
R4830	T8112	T8113	amod	defective,function
R4831	T8113	T8111	pobj	function,to
R4832	T8114	T8113	compound	osteoclast,function
R4833	T8115	T8116	punct	[,55
R4834	T8116	T8109	parataxis	55,attributed
R4835	T8117	T8118	punct	−,59
R4836	T8118	T8116	prep	59,55
R4837	T8119	T8116	punct	],55
R4838	T8120	T8078	punct	.,shown
R4839	T8122	T8123	nsubj	We,cultured
R4840	T8124	T8123	advmod	therefore,cultured
R4841	T8125	T8126	amod	mature,osteoclasts
R4842	T8126	T8123	dobj	osteoclasts,cultured
R4843	T8127	T8126	acl	harvested,osteoclasts
R4844	T8128	T8127	prep	from,harvested
R4845	T8129	T8130	nmod	Sam68,mice
R4846	T8130	T8128	pobj	mice,from
R4847	T8131	T8129	punct	+,Sam68
R4848	T8132	T8129	punct	/,Sam68
R4849	T8133	T8129	punct	+,Sam68
R4850	T8134	T8129	cc	and,Sam68
R4851	T8135	T8129	conj	Sam68,Sam68
R4852	T8136	T8135	punct	−,Sam68
R4853	T8137	T8135	punct	/,Sam68
R4854	T8138	T8135	punct	−,Sam68
R4855	T8139	T8140	advmod	ex,vivo
R4856	T8140	T8123	advmod	vivo,cultured
R4857	T8141	T8123	prep	on,cultured
R4858	T8142	T8143	compound	dentin,slices
R4859	T8143	T8141	pobj	slices,on
R4860	T8144	T8145	aux	to,quantify
R4861	T8145	T8123	advcl	quantify,cultured
R4862	T8146	T8147	poss	their,capacity
R4863	T8147	T8145	dobj	capacity,quantify
R4864	T8148	T8147	amod	resorptive,capacity
R4865	T8149	T8123	punct	.,cultured
R4866	T8151	T8152	det	The,fact
R4867	T8152	T8153	nsubj	fact,made
R4868	T8154	T8155	mark	that,looked
R4869	T8155	T8152	acl	looked,fact
R4870	T8156	T8157	nmod	Sam68,osteoclasts
R4871	T8157	T8155	nsubj	osteoclasts,looked
R4872	T8158	T8156	punct	−,Sam68
R4873	T8159	T8156	punct	/,Sam68
R4874	T8160	T8156	punct	−,Sam68
R4875	T8161	T8155	cc	and,looked
R4876	T8162	T8155	conj	acted,looked
R4877	T8163	T8162	prep	like,acted
R4878	T8164	T8165	nmod	Sam68,osteoclasts
R4879	T8165	T8163	pobj	osteoclasts,like
R4880	T8166	T8164	punct	+,Sam68
R4881	T8167	T8164	punct	/,Sam68
R4882	T8168	T8164	punct	+,Sam68
R4883	T8169	T8170	advmod	ex,vivo
R4884	T8170	T8162	advmod	vivo,acted
R4885	T8171	T8170	cc	and,vivo
R4886	T8172	T8173	advmod	in,vivo
R4887	T8173	T8170	conj	vivo,vivo
R4888	T8174	T8175	nsubj	it,unlikely
R4889	T8175	T8153	ccomp	unlikely,made
R4890	T8176	T8177	mark	that,was
R4891	T8177	T8175	advcl	was,unlikely
R4892	T8178	T8177	nsubj	this,was
R4893	T8179	T8180	det	the,source
R4894	T8180	T8177	attr	source,was
R4895	T8181	T8180	amod	primary,source
R4896	T8182	T8180	prep	of,source
R4897	T8183	T8184	det	the,difference
R4898	T8184	T8182	pobj	difference,of
R4899	T8185	T8184	prep	in,difference
R4900	T8186	T8187	compound	bone,metabolism
R4901	T8187	T8185	pobj	metabolism,in
R4902	T8188	T8177	prep	in,was
R4903	T8189	T8190	nummod	12,month
R4904	T8190	T8192	npadvmod	month,old
R4905	T8191	T8190	punct	-,month
R4906	T8192	T8194	amod	old,mice
R4907	T8193	T8192	punct	-,old
R4908	T8194	T8188	pobj	mice,in
R4909	T8195	T8194	nmod	Sam68,mice
R4910	T8196	T8195	punct	−,Sam68
R4911	T8197	T8195	punct	/,Sam68
R4912	T8198	T8195	punct	−,Sam68
R4913	T8199	T8153	punct	.,made
R4914	T8201	T8202	det	The,fact
R4915	T8202	T8203	nsubj	fact,suggested
R4916	T8204	T8205	mark	that,were
R4917	T8205	T8202	acl	were,fact
R4918	T8206	T8207	det	the,levels
R4919	T8207	T8205	nsubj	levels,were
R4920	T8208	T8207	compound	CTX,levels
R4921	T8209	T8205	acomp	lower,were
R4922	T8210	T8205	prep	in,were
R4923	T8211	T8212	amod	young,mice
R4924	T8212	T8210	pobj	mice,in
R4925	T8213	T8211	cc	and,young
R4926	T8214	T8211	conj	old,young
R4927	T8215	T8212	nmod	Sam68,mice
R4928	T8216	T8215	punct	−,Sam68
R4929	T8217	T8215	punct	/,Sam68
R4930	T8218	T8215	punct	−,Sam68
R4931	T8219	T8220	mark	that,is
R4932	T8220	T8203	ccomp	is,suggested
R4933	T8221	T8220	expl	there,is
R4934	T8222	T8223	amod	reduced,resorption
R4935	T8223	T8220	attr	resorption,is
R4936	T8224	T8223	compound	bone,resorption
R4937	T8225	T8223	prep	compared,resorption
R4938	T8226	T8225	prep	with,compared
R4939	T8227	T8228	amod	wild,type
R4940	T8228	T8230	compound	type,controls
R4941	T8229	T8228	punct	-,type
R4942	T8230	T8226	pobj	controls,with
R4943	T8231	T8230	compound	littermate,controls
R4944	T8232	T8203	punct	.,suggested
R4945	T8234	T8235	advmod	However,occurred
R4946	T8236	T8235	punct	", ",occurred
R4947	T8237	T8238	det	this,reduction
R4948	T8238	T8235	nsubj	reduction,occurred
R4949	T8239	T8238	prep	in,reduction
R4950	T8240	T8241	compound	bone,resorption
R4951	T8241	T8239	pobj	resorption,in
R4952	T8242	T8235	prep	with,occurred
R4953	T8243	T8244	amod	normal,activity
R4954	T8244	T8242	pobj	activity,with
R4955	T8245	T8244	compound	osteoclast,activity
R4956	T8246	T8235	punct	", ",occurred
R4957	T8247	T8248	mark	as,assessed
R4958	T8248	T8235	advcl	assessed,occurred
R4959	T8249	T8248	prep	by,assessed
R4960	T8250	T8251	advmod	in,vitro
R4961	T8251	T8252	amod	vitro,culturing
R4962	T8252	T8249	pobj	culturing,by
R4963	T8253	T8235	punct	.,occurred
R4964	T8255	T8256	det	These,observations
R4965	T8256	T8257	nsubj	observations,are
R4966	T8258	T8257	acomp	consistent,are
R4967	T8259	T8258	prep	with,consistent
R4968	T8260	T8261	det	the,mice
R4969	T8261	T8266	nsubj	mice,having
R4970	T8262	T8261	nmod	Sam68,mice
R4971	T8263	T8262	punct	−,Sam68
R4972	T8264	T8262	punct	/,Sam68
R4973	T8265	T8262	punct	−,Sam68
R4974	T8266	T8259	pcomp	having,with
R4975	T8267	T8268	det	a,phenotype
R4976	T8268	T8266	dobj	phenotype,having
R4977	T8269	T8270	npadvmod	youth,like
R4978	T8270	T8268	amod	like,phenotype
R4979	T8271	T8270	punct	-,like
R4980	T8272	T8268	compound	bone,phenotype
R4981	T8273	T8257	punct	.,are
R4982	T8275	T8276	advmod	However,is
R4983	T8277	T8276	punct	", ",is
R4984	T8278	T8276	nsubj	it,is
R4985	T8279	T8276	advmod	still,is
R4986	T8280	T8276	acomp	possible,is
R4987	T8281	T8276	punct	", ",is
R4988	T8282	T8283	mark	that,manifest
R4989	T8283	T8276	ccomp	manifest,is
R4990	T8284	T8285	det	a,impairment
R4991	T8285	T8283	nsubj	impairment,manifest
R4992	T8286	T8285	amod	mild,impairment
R4993	T8287	T8285	prep	in,impairment
R4994	T8288	T8289	nmod	Sam68,mice
R4995	T8289	T8293	compound	mice,function
R4996	T8290	T8288	punct	−,Sam68
R4997	T8291	T8288	punct	/,Sam68
R4998	T8292	T8288	punct	−,Sam68
R4999	T8293	T8287	pobj	function,in
R5000	T8294	T8293	compound	osteoclast,function
R5001	T8295	T8283	aux	may,manifest
R5002	T8296	T8283	dobj	itself,manifest
R5003	T8297	T8283	advmod	later,manifest
R5004	T8298	T8297	prep	in,later
R5005	T8299	T8298	pobj	life,in
R5006	T8300	T8283	prep	in,manifest
R5007	T8301	T8302	amod	overall,accumulation
R5008	T8302	T8300	pobj	accumulation,in
R5009	T8303	T8302	prep	of,accumulation
R5010	T8304	T8303	pobj	bone,of
R5011	T8305	T8276	cc	and,is
R5012	T8306	T8307	nsubj	this,require
R5013	T8307	T8276	conj	require,is
R5014	T8308	T8307	aux	will,require
R5015	T8309	T8310	amod	further,studies
R5016	T8310	T8307	dobj	studies,require
R5017	T8311	T8310	amod	detailed,studies
R5018	T8312	T8276	punct	.,is
R5019	T8314	T8315	advmod	Ex,vivo
R5020	T8315	T8316	amod	vivo,differentiation
R5021	T8316	T8317	nsubj	differentiation,revealed
R5022	T8318	T8316	prep	of,differentiation
R5023	T8319	T8320	amod	primary,cells
R5024	T8320	T8318	pobj	cells,of
R5025	T8321	T8322	nmod	bone,marrow
R5026	T8322	T8320	nmod	marrow,cells
R5027	T8323	T8320	amod	stromal,cells
R5028	T8324	T8320	punct	", ",cells
R5029	T8325	T8320	acl	harvested,cells
R5030	T8326	T8325	prep	from,harvested
R5031	T8327	T8328	nmod	Sam68,mice
R5032	T8328	T8326	pobj	mice,from
R5033	T8329	T8327	punct	+,Sam68
R5034	T8330	T8327	punct	/,Sam68
R5035	T8331	T8327	punct	+,Sam68
R5036	T8332	T8327	cc	and,Sam68
R5037	T8333	T8327	conj	Sam68,Sam68
R5038	T8334	T8333	punct	−,Sam68
R5039	T8335	T8333	punct	/,Sam68
R5040	T8336	T8333	punct	−,Sam68
R5041	T8337	T8317	punct	", ",revealed
R5042	T8338	T8317	prep	down,revealed
R5043	T8339	T8340	det	the,lineage
R5044	T8340	T8338	pobj	lineage,down
R5045	T8341	T8340	compound	osteoblast,lineage
R5046	T8342	T8343	det	an,advantage
R5047	T8343	T8317	dobj	advantage,revealed
R5048	T8344	T8343	amod	osteogenic,advantage
R5049	T8345	T8317	prep	in,revealed
R5050	T8346	T8347	det	the,cultures
R5051	T8347	T8345	pobj	cultures,in
R5052	T8348	T8347	prep	of,cultures
R5053	T8349	T8348	pobj	cells,of
R5054	T8350	T8349	acl	derived,cells
R5055	T8351	T8350	prep	from,derived
R5056	T8352	T8353	det	the,mice
R5057	T8353	T8351	pobj	mice,from
R5058	T8354	T8353	nmod	Sam68,mice
R5059	T8355	T8354	punct	−,Sam68
R5060	T8356	T8354	punct	/,Sam68
R5061	T8357	T8354	punct	−,Sam68
R5062	T8358	T8317	punct	.,revealed
R5063	T8360	T8361	nsubj	It,be
R5064	T8362	T8361	aux	will,be
R5065	T8363	T8361	acomp	important,be
R5066	T8364	T8365	aux	to,demonstrate
R5067	T8365	T8361	xcomp	demonstrate,be
R5068	T8366	T8367	mark	that,observed
R5069	T8367	T8365	ccomp	observed,demonstrate
R5070	T8368	T8369	det	a,effect
R5071	T8369	T8367	nsubjpass	effect,observed
R5072	T8370	T8369	amod	similar,effect
R5073	T8407	T8392	prep	into,differentiated
R5074	T8371	T8367	auxpass	is,observed
R5075	T8408	T8407	pobj	osteoblasts,into
R5076	T8372	T8367	advcl	using,observed
R5077	T8409	T8392	prep	with,differentiated
R5078	T8410	T8409	pobj	BMP2,with
R5079	T8411	T8389	punct	.,observed
R5080	T8413	T8414	poss	Our,findings
R5081	T8373	T8374	amod	primary,cells
R5082	T8414	T8415	nsubj	findings,indicate
R5083	T8416	T8417	mark	that,develop
R5084	T8374	T8372	dobj	cells,using
R5085	T8417	T8414	advcl	develop,findings
R5086	T8418	T8419	amod	aged,mice
R5087	T8375	T8376	nmod	bone,marrow
R5088	T8419	T8417	nsubj	mice,develop
R5089	T8420	T8419	nmod	Sam68,mice
R5090	T8421	T8420	punct	−,Sam68
R5091	T8376	T8374	nmod	marrow,cells
R5092	T8422	T8420	punct	/,Sam68
R5093	T8423	T8420	punct	−,Sam68
R5094	T8377	T8374	amod	stromal,cells
R5095	T8424	T8417	aux	do,develop
R5096	T8425	T8417	neg	not,develop
R5097	T8426	T8427	amod	fatty,marrow
R5098	T8378	T8374	prep	from,cells
R5099	T8427	T8417	dobj	marrow,develop
R5100	T8428	T8427	compound	bone,marrow
R5101	T8379	T8380	amod	aged,mice
R5102	T8429	T8417	cc	and,develop
R5103	T8430	T8431	mark	that,have
R5104	T8431	T8417	conj	have,develop
R5105	T8380	T8378	pobj	mice,from
R5106	T8432	T8431	nsubj	MEFs,have
R5107	T8433	T8432	acl	derived,MEFs
R5108	T8434	T8433	prep	from,derived
R5109	T8381	T8380	nmod	Sam68,mice
R5110	T8435	T8436	nmod	Sam68,mice
R5111	T8436	T8434	pobj	mice,from
R5112	T8382	T8381	punct	−,Sam68
R5113	T8437	T8435	punct	−,Sam68
R5114	T8438	T8435	punct	/,Sam68
R5115	T8383	T8381	punct	/,Sam68
R5116	T8439	T8435	punct	−,Sam68
R5117	T8440	T8441	amod	impaired,differentiation
R5118	T8441	T8431	dobj	differentiation,have
R5119	T8442	T8441	compound	adipocyte,differentiation
R5120	T8384	T8381	punct	−,Sam68
R5121	T8443	T8415	punct	", ",indicate
R5122	T8444	T8445	mark	that,regulates
R5123	T8445	T8415	ccomp	regulates,indicate
R5124	T8385	T8361	punct	.,be
R5125	T8446	T8445	nsubj	Sam68,regulates
R5126	T8447	T8448	preconj	both,adipocyte
R5127	T8448	T8449	nmod	adipocyte,differentiation
R5128	T8387	T8388	amod	Similar,findings
R5129	T8449	T8445	dobj	differentiation,regulates
R5130	T8450	T8448	cc	and,adipocyte
R5131	T8451	T8448	conj	osteoblast,adipocyte
R5132	T8452	T8415	punct	.,indicate
R5133	T8454	T8455	det	These,findings
R5134	T8455	T8456	nsubj	findings,identify
R5135	T8388	T8389	nsubjpass	findings,observed
R5136	T8390	T8389	auxpass	were,observed
R5137	T8457	T8456	dobj	Sam68,identify
R5138	T8458	T8456	prep	as,identify
R5139	T8391	T8392	advmod	when,differentiated
R5140	T8459	T8460	det	the,protein
R5141	T8460	T8458	pobj	protein,as
R5142	T8392	T8389	advcl	differentiated,observed
R5143	T8461	T8460	amod	first,protein
R5144	T8462	T8463	npadvmod	RNA,binding
R5145	T8463	T8460	amod	binding,protein
R5146	T8393	T8394	amod	embryonic,cells
R5147	T8464	T8465	aux	to,regulate
R5148	T8465	T8460	advcl	regulate,protein
R5149	T8394	T8392	nsubjpass	cells,differentiated
R5150	T8466	T8467	amod	mesenchymal,differentiation
R5151	T8467	T8465	dobj	differentiation,regulate
R5152	T8468	T8467	compound	cell,differentiation
R5153	T8395	T8394	amod	mesenchymal,cells
R5154	T8469	T8456	cc	and,identify
R5155	T8470	T8471	det	the,challenge
R5156	T8471	T8472	nsubj	challenge,be
R5157	T8396	T8394	amod	multipotential,cells
R5158	T8472	T8456	conj	be,identify
R5159	T8473	T8472	aux	will,be
R5160	T8474	T8475	aux	to,identify
R5161	T8397	T8394	compound	progenitor,cells
R5162	T8475	T8472	xcomp	identify,be
R5163	T8476	T8477	det	the,targets
R5164	T8477	T8475	dobj	targets,identify
R5165	T8398	T8394	appos	C3H10T1,cells
R5166	T8478	T8477	amod	specific,targets
R5167	T8479	T8477	compound	RNA,targets
R5168	T8399	T8398	punct	/,C3H10T1
R5169	T8480	T8481	dep	that,regulates
R5170	T8400	T8398	nummod	2,C3H10T1
R5171	T8481	T8477	relcl	regulates,targets
R5172	T8482	T8481	nsubj	it,regulates
R5173	T8483	T8481	prep	during,regulates
R5174	T8401	T8394	acl	treated,cells
R5175	T8484	T8485	det	this,process
R5176	T8485	T8483	pobj	process,during
R5177	T8486	T8472	punct	.,be
R5178	T8402	T8401	prep	with,treated
R5179	T8488	T8489	det	The,fact
R5180	T8489	T8490	nsubj	fact,raises
R5181	T8403	T8404	compound	Sam68,shRNA
R5182	T8491	T8492	mark	that,altered
R5183	T8492	T8489	acl	altered,fact
R5184	T8404	T8402	pobj	shRNA,with
R5185	T8405	T8392	punct	", ",differentiated
R5186	T8493	T8494	compound	osteoblast,function
R5187	T8406	T8392	auxpass	were,differentiated
R5188	T8494	T8492	nsubjpass	function,altered
R5189	T8495	T8492	auxpass	is,altered
R5190	T8496	T8492	prep	in,altered
R5191	T8513	T8514	compound	bone,mass
R5192	T8497	T8498	nmod	Src,mice
R5193	T8498	T8496	pobj	mice,in
R5194	T8499	T8497	punct	−,Src
R5195	T8514	T8512	pobj	mass,of
R5196	T8500	T8497	punct	/,Src
R5197	T8501	T8497	punct	−,Src
R5198	T8502	T8503	punct	[,61
R5199	T8515	T8511	prep	in,preservation
R5200	T8503	T8492	parataxis	61,altered
R5201	T8504	T8503	nummod	60,61
R5202	T8505	T8503	punct	",",61
R5203	T8516	T8517	det	the,mice
R5204	T8506	T8503	punct	],61
R5205	T8507	T8508	det	the,possibility
R5206	T8508	T8490	dobj	possibility,raises
R5207	T8517	T8515	pobj	mice,in
R5208	T8509	T8510	mark	that,linked
R5209	T8510	T8508	acl	linked,possibility
R5210	T8511	T8510	nsubjpass	preservation,linked
R5211	T8518	T8517	nmod	Sam68,mice
R5212	T8512	T8511	prep	of,preservation
R5213	T8519	T8518	punct	−,Sam68
R5214	T8520	T8518	punct	/,Sam68
R5215	T8521	T8518	punct	−,Sam68
R5216	T8522	T8510	aux	could,linked
R5217	T8523	T8510	auxpass	be,linked
R5218	T8524	T8510	prep	with,linked
R5219	T8619	T8617	amod	sympathetic,pathway
R5220	T8525	T8510	cc	and,linked
R5221	T8620	T8619	punct	-,sympathetic
R5222	T8621	T8615	acomp	unaltered,is
R5223	T8622	T8615	prep	in,is
R5224	T8526	T8510	conj	regulated,linked
R5225	T8623	T8624	nmod	Sam68,mice
R5226	T8527	T8526	agent	by,regulated
R5227	T8624	T8622	pobj	mice,in
R5228	T8528	T8526	dobj	Src,regulated
R5229	T8625	T8623	punct	−,Sam68
R5230	T8626	T8623	punct	/,Sam68
R5231	T8529	T8490	punct	.,raises
R5232	T8627	T8623	punct	−,Sam68
R5233	T8531	T8532	det	The,pathway
R5234	T8628	T8615	cc	and,is
R5235	T8629	T8630	mark	that,explain
R5236	T8630	T8615	conj	explain,is
R5237	T8631	T8632	det	the,lowering
R5238	T8632	T8630	nsubj	lowering,explain
R5239	T8633	T8632	prep	of,lowering
R5240	T8634	T8633	pobj	leptin,of
R5241	T8532	T8533	nsubjpass	pathway,identified
R5242	T8635	T8630	aux	may,explain
R5243	T8636	T8637	det	the,levels
R5244	T8637	T8630	dobj	levels,explain
R5245	T8534	T8535	prep	by,regulates
R5246	T8638	T8637	amod	lower,levels
R5247	T8639	T8637	prep	of,levels
R5248	T8640	T8639	pobj	CTX,of
R5249	T8535	T8532	relcl	regulates,pathway
R5250	T8641	T8637	prep	in,levels
R5251	T8642	T8643	det	the,serum
R5252	T8643	T8641	pobj	serum,in
R5253	T8536	T8534	pobj	which,by
R5254	T8644	T8643	prep	of,serum
R5255	T8645	T8646	nmod	Sam68,mice
R5256	T8646	T8644	pobj	mice,of
R5257	T8537	T8535	nsubj	leptin,regulates
R5258	T8647	T8645	punct	−,Sam68
R5259	T8648	T8645	punct	/,Sam68
R5260	T8649	T8645	punct	−,Sam68
R5261	T8538	T8539	compound	bone,resorption
R5262	T8650	T8612	punct	.,suggest
R5263	T8652	T8653	det	These,findings
R5264	T8539	T8535	dobj	resorption,regulates
R5265	T8653	T8654	nsubj	findings,suggest
R5266	T8654	T8655	ccomp	suggest,results
R5267	T8540	T8533	auxpass	was,identified
R5268	T8656	T8657	mark	that,regulating
R5269	T8657	T8654	ccomp	regulating,suggest
R5270	T8541	T8542	aux	to,involve
R5271	T8658	T8657	nsubj	Sam68,regulating
R5272	T8659	T8657	aux	may,regulating
R5273	T8542	T8533	xcomp	involve,identified
R5274	T8660	T8657	aux	be,regulating
R5275	T8661	T8662	compound	bone,metabolism
R5276	T8662	T8657	dobj	metabolism,regulating
R5277	T8543	T8544	det	the,system
R5278	T8663	T8657	prep	at,regulating
R5279	T8664	T8665	nummod	two,levels
R5280	T8665	T8663	pobj	levels,at
R5281	T8544	T8542	dobj	system,involve
R5282	T8666	T8665	amod	different,levels
R5283	T8667	T8655	punct	: ,results
R5284	T8668	T8669	punct	(,1
R5285	T8545	T8544	amod	sympathetic,system
R5286	T8669	T8655	meta	1,results
R5287	T8670	T8669	punct	),1
R5288	T8671	T8672	det	the,absence
R5289	T8672	T8655	nsubj	absence,results
R5290	T8673	T8672	prep	of,absence
R5291	T8674	T8673	pobj	Sam68,of
R5292	T8546	T8544	amod	nervous,system
R5293	T8675	T8655	prep	in,results
R5294	T8676	T8677	amod	lower,levels
R5295	T8677	T8675	pobj	levels,in
R5296	T8547	T8544	acl	relaying,system
R5297	T8678	T8677	compound	leptin,levels
R5298	T8679	T8680	dep	that,reduce
R5299	T8680	T8677	relcl	reduce,levels
R5300	T8548	T8547	prep	to,relaying
R5301	T8681	T8680	aux	may,reduce
R5302	T8682	T8683	compound	bone,resorption
R5303	T8683	T8680	dobj	resorption,reduce
R5304	T8549	T8550	det	the,osteoblasts
R5305	T8684	T8680	prep	via,reduce
R5306	T8685	T8686	det	the,system
R5307	T8686	T8684	pobj	system,via
R5308	T8550	T8548	pobj	osteoblasts,to
R5309	T8687	T8686	amod	sympathetic,system
R5310	T8688	T8686	amod	nervous,system
R5311	T8689	T8655	cc	and,results
R5312	T8551	T8547	prep	via,relaying
R5313	T8690	T8691	punct	(,2
R5314	T8691	T8692	meta	2,favors
R5315	T8692	T8655	conj	favors,results
R5316	T8552	T8553	det	the,pathway
R5317	T8693	T8691	punct	),2
R5318	T8694	T8695	det	the,absence
R5319	T8695	T8692	nsubj	absence,favors
R5320	T8553	T8551	pobj	pathway,via
R5321	T8696	T8695	prep	of,absence
R5322	T8697	T8696	pobj	Sam68,of
R5323	T8698	T8699	nmod	osteoblast,differentiation
R5324	T8554	T8555	npadvmod	β,adrenergic
R5325	T8699	T8692	dobj	differentiation,favors
R5326	T8700	T8698	punct	", ",osteoblast
R5327	T8701	T8702	advmod	rather,than
R5328	T8555	T8553	amod	adrenergic,pathway
R5329	T8702	T8698	cc	than,osteoblast
R5330	T8703	T8698	conj	adipocyte,osteoblast
R5331	T8556	T8555	punct	-,adrenergic
R5332	T8704	T8699	punct	", ",differentiation
R5333	T8705	T8655	punct	.,results
R5334	T8557	T8547	advcl	leading,relaying
R5335	T8707	T8708	prep	In,define
R5336	T8558	T8557	prep	to,leading
R5337	T8709	T8707	pobj	conclusion,In
R5338	T8710	T8708	punct	", ",define
R5339	T8711	T8712	poss	our,data
R5340	T8559	T8560	det	the,release
R5341	T8560	T8558	pobj	release,to
R5345	T8561	T8560	prep	of,release
R5346	T8715	T8714	amod	physiologic,role
R5347	T8716	T8714	prep	for,role
R5348	T8562	T8563	compound	growth,factors
R5349	T8717	T8716	pobj	Sam68,for
R5350	T8718	T8714	prep	in,role
R5351	T8563	T8561	pobj	factors,of
R5352	T8564	T8563	prep	including,factors
R5353	T8719	T8720	compound	bone,metabolism
R5354	T8565	T8564	pobj	RANKL,including
R5355	T8720	T8718	pobj	metabolism,in
R5356	T8566	T8567	dep	that,causes
R5357	T8721	T8720	cc	and,metabolism
R5358	T8722	T8723	nmod	bone,marrow
R5359	T8567	T8563	relcl	causes,factors
R5360	T8723	T8724	nmod	marrow,differentiation
R5361	T8724	T8720	conj	differentiation,metabolism
R5362	T8568	T8569	det	the,osteoclasts
R5363	T8569	T8570	nsubj	osteoclasts,thrive
R5364	T8725	T8726	amod	mesenchymal,cell
R5365	T8570	T8567	ccomp	thrive,causes
R5366	T8726	T8724	compound	cell,differentiation
R5367	T8727	T8726	compound	stem,cell
R5368	T8571	T8570	aux	to,thrive
R5369	T8728	T8708	punct	.,define
R5370	T8730	T8731	det	The,phenotype
R5371	T8572	T8573	punct	[,8
R5372	T8731	T8733	nsubj	phenotype,imply
R5373	T8732	T8731	compound	bone,phenotype
R5374	T8573	T8533	parataxis	8,identified
R5375	T8734	T8731	acl	observed,phenotype
R5376	T8735	T8734	prep	in,observed
R5377	T8574	T8573	punct	",",8
R5378	T8736	T8737	nmod	Sam68,mice
R5379	T8737	T8735	pobj	mice,in
R5380	T8738	T8736	punct	−,Sam68
R5381	T8575	T8573	appos	18,8
R5382	T8739	T8736	punct	/,Sam68
R5383	T8740	T8736	punct	−,Sam68
R5384	T8576	T8577	punct	–,20
R5385	T8741	T8742	mark	that,prevent
R5386	T8742	T8733	ccomp	prevent,imply
R5387	T8743	T8742	nsubj	inhibitors,prevent
R5388	T8577	T8575	prep	20,18
R5389	T8744	T8743	prep	of,inhibitors
R5390	T8745	T8744	pobj	Sam68,of
R5391	T8746	T8742	aux	could,prevent
R5392	T8747	T8748	npadvmod	age,related
R5393	T8748	T8750	amod	related,loss
R5394	T8749	T8748	punct	-,related
R5395	T8578	T8573	punct	],8
R5396	T8750	T8742	dobj	loss,prevent
R5397	T8751	T8750	compound	bone,loss
R5398	T8579	T8533	punct	.,identified
R5399	T8752	T8733	punct	.,imply
R5400	T8754	T8755	advmod	Furthermore,suggest
R5401	T8581	T8582	det	The,lowering
R5402	T8756	T8755	punct	", ",suggest
R5403	T8757	T8758	det	the,results
R5404	T8758	T8755	nsubj	results,suggest
R5405	T8582	T8583	nsubj	lowering,is
R5406	T8759	T8755	advmod	also,suggest
R5407	T8760	T8761	mark	that,influence
R5408	T8761	T8755	ccomp	influence,suggest
R5409	T8584	T8582	prep	of,lowering
R5410	T8762	T8763	compound	Sam68,levels
R5411	T8763	T8761	nsubj	levels,influence
R5412	T8764	T8763	compound	expression,levels
R5413	T8765	T8763	punct	", ",levels
R5414	T8585	T8586	compound	leptin,levels
R5415	T8766	T8763	conj	hypomorphism,levels
R5416	T8767	T8766	punct	", ",hypomorphism
R5417	T8768	T8766	cc	and,hypomorphism
R5418	T8586	T8584	pobj	levels,of
R5419	T8769	T8766	conj	mutations,hypomorphism
R5420	T8770	T8763	prep	in,levels
R5421	T8771	T8770	pobj	humans,in
R5422	T8587	T8582	prep	in,lowering
R5423	T8772	T8761	aux	may,influence
R5424	T8773	T8761	dobj	susceptibility,influence
R5425	T8774	T8773	prep	to,susceptibility
R5426	T8588	T8589	amod	aged,mice
R5427	T8775	T8776	compound	marrow,adipocyte
R5428	T8776	T8777	compound	adipocyte,accumulation
R5429	T8777	T8774	pobj	accumulation,to
R5430	T8589	T8587	pobj	mice,in
R5431	T8778	T8777	cc	and,accumulation
R5432	T8779	T8777	conj	osteoporosis,accumulation
R5433	T8780	T8755	punct	.,suggest
R5434	T8590	T8589	nmod	Sam68,mice
R5435	T8782	T8783	poss	Our,findings
R5436	T8783	T8784	nsubj	findings,identify
R5437	T8591	T8590	punct	−,Sam68
R5438	T8785	T8784	advmod	also,identify
R5439	T8786	T8787	det	a,model
R5440	T8592	T8590	punct	/,Sam68
R5441	T8787	T8784	dobj	model,identify
R5442	T8788	T8787	amod	new,model
R5443	T8789	T8787	compound	animal,model
R5444	T8790	T8791	aux	to,study
R5445	T8791	T8787	advcl	study,model
R5446	T8792	T8793	amod	aging,loss
R5447	T8593	T8590	punct	−,Sam68
R5448	T8793	T8791	dobj	loss,study
R5449	T8794	T8793	compound	bone,loss
R5450	T8594	T8583	acomp	consistent,is
R5451	T8795	T8784	punct	.,identify
R5452	T8595	T8594	prep	with,consistent
R5453	T8596	T8597	det	these,mice
R5454	T8597	T8598	nsubj	mice,having
R5455	T8598	T8595	pcomp	having,with
R5456	T8599	T8600	det	a,mass
R5457	T8600	T8598	dobj	mass,having
R5458	T8601	T8600	amod	high,mass
R5459	T8602	T8600	compound	bone,mass
R5460	T8603	T8598	prep	compared,having
R5461	T8604	T8603	prep	with,compared
R5462	T8605	T8606	poss	their,littermates
R5463	T8606	T8604	pobj	littermates,with
R5464	T8607	T8606	amod	aged,littermates
R5465	T8608	T8583	punct	.,is
R5466	T8610	T8611	det	These,data
R5467	T8611	T8612	nsubj	data,suggest
R5468	T8613	T8612	aux	would,suggest
R5469	T8614	T8615	mark	that,is
R5470	T8615	T8612	advcl	is,suggest
R5471	T8616	T8617	det	the,pathway
R5472	T8617	T8615	nsubj	pathway,is
R5473	T8618	T8619	npadvmod	leptin,sympathetic
R5474	T8863	T8864	amod	Histologic,analyses
R5475	T8865	T8863	punct	", ",Histologic
R5476	T8866	T8863	conj	immunohistochemical,Histologic
R5477	T8867	T8866	punct	", ",immunohistochemical
R5478	T8868	T8866	cc	and,immunohistochemical
R5479	T8869	T8866	conj	histomorphometric,immunohistochemical
R5480	T8870	T8864	punct	.,analyses
R5481	T8872	T8873	det	All,analyses
R5482	T8873	T8874	nsubjpass	analyses,performed
R5483	T8875	T8874	auxpass	were,performed
R5484	T8876	T8877	advmod	essentially,described
R5485	T8877	T8874	advcl	described,performed
R5486	T8878	T8877	mark	as,described
R5487	T8879	T8877	advmod	previously,described
R5488	T8880	T8881	punct	[,63
R5489	T8881	T8874	parataxis	63,performed
R5490	T8882	T8881	nummod	62,63
R5491	T8883	T8881	punct	",",63
R5492	T8884	T8881	punct	],63
R5493	T8885	T8874	punct	.,performed
R5494	T8887	T8888	advmod	Briefly,removed
R5495	T8889	T8888	punct	", ",removed
R5496	T8890	T8891	amod	embryonic,mice
R5497	T8891	T8888	nsubjpass	mice,removed
R5498	T8892	T8888	auxpass	were,removed
R5499	T8893	T8888	prep	from,removed
R5500	T8894	T8895	amod	timed,dams
R5501	T8895	T8893	pobj	dams,from
R5502	T8896	T8895	amod	pregnant,dams
R5503	T8897	T8888	prep	at,removed
R5504	T8898	T8897	pobj	E14.5,at
R5505	T8899	T8898	cc	and,E14.5
R5506	T8900	T8898	conj	E16.5,E14.5
R5507	T8901	T8888	cc	and,removed
R5508	T8902	T8888	conj	fixed,removed
R5509	T8903	T8902	advcl	intact,fixed
R5510	T8904	T8902	prep	for,fixed
R5511	T8905	T8906	nummod	36,h
R5512	T8906	T8904	pobj	h,for
R5513	T8907	T8902	prep	in,fixed
R5514	T8908	T8909	nummod	4,%
R5515	T8909	T8910	compound	%,paraformaldehyde
R5516	T8910	T8907	pobj	paraformaldehyde,in
R5517	T8911	T8902	punct	", ",fixed
R5518	T8912	T8902	conj	rinsed,fixed
R5519	T8913	T8912	advmod	thoroughly,rinsed
R5520	T8914	T8912	prep	in,rinsed
R5521	T8915	T8914	pobj	PBS,in
R5522	T8916	T8912	punct	", ",rinsed
R5523	T8917	T8912	cc	and,rinsed
R5524	T8918	T8912	conj	processed,rinsed
R5525	T8919	T8918	prep	for,processed
R5526	T8920	T8921	compound	paraffin,embedding
R5527	T8921	T8919	pobj	embedding,for
R5528	T8922	T8888	punct	.,removed
R5529	T8924	T8925	amod	Serial,sections
R5530	T8925	T8929	nsubjpass	sections,cut
R5531	T8926	T8927	nummod	4,μm
R5532	T8927	T8925	compound	μm,sections
R5533	T8928	T8927	punct	-,μm
R5534	T8930	T8929	auxpass	were,cut
R5535	T8931	T8929	prep	on,cut
R5536	T8932	T8933	det	a,microtome
R5537	T8933	T8931	pobj	microtome,on
R5538	T8934	T8933	amod	modified,microtome
R5539	T8935	T8936	nmod	Leica,RM
R5540	T8936	T8933	nmod	RM,microtome
R5541	T8937	T8936	nummod	2155,RM
R5542	T8938	T8933	amod	rotary,microtome
R5543	T8939	T8940	punct	(,Microsystems
R5544	T8940	T8933	parataxis	Microsystems,microtome
R5545	T8941	T8940	compound	Leica,Microsystems
R5546	T8942	T8940	punct	", ",Microsystems
R5547	T8943	T8944	compound	Richmond,Hill
R5548	T8944	T8940	npadvmod	Hill,Microsystems
R5549	T8945	T8940	punct	", ",Microsystems
R5550	T8946	T8940	npadvmod	Ontario,Microsystems
R5551	T8947	T8940	punct	", ",Microsystems
R5552	T8948	T8940	npadvmod	Canada,Microsystems
R5553	T8949	T8940	punct	),Microsystems
R5554	T8950	T8929	punct	", ",cut
R5555	T8951	T8929	conj	stained,cut
R5556	T8952	T8951	prep	with,stained
R5557	T8953	T8954	det	a,dilution
R5558	T8954	T8952	pobj	dilution,with
R5559	T8955	T8954	nummod	1,dilution
R5560	T8956	T8957	punct	:,600
R5561	T8957	T8955	prep	600,1
R5562	T8958	T8954	prep	of,dilution
R5563	T8959	T8960	det	the,antibody
R5564	T8960	T8958	pobj	antibody,of
R5565	T8961	T8960	nmod	AD1,antibody
R5566	T8962	T8960	amod	anti-Sam68,antibody
R5567	T8963	T8964	punct	[,46
R5568	T8964	T8951	parataxis	46,stained
R5569	T8965	T8964	punct	],46
R5570	T8966	T8951	cc	and,stained
R5571	T8967	T8951	conj	counterstained,stained
R5572	T8968	T8967	prep	with,counterstained
R5573	T8969	T8970	preconj	either,green
R5574	T8970	T8968	pobj	green,with
R5575	T8971	T8970	compound	methyl,green
R5576	T8972	T8970	cc	or,green
R5577	T8973	T8970	conj	hematoxylin,green
R5578	T8974	T8929	punct	.,cut
R5579	T8976	T8977	amod	Adult,mice
R5580	T8977	T8978	nsubj	mice,given
R5581	T8979	T8978	aux	were,given
R5582	T8980	T8981	det	an,injection
R5583	T8981	T8978	dobj	injection,given
R5584	T8982	T8981	amod	intraperitoneal,injection
R5585	T8983	T8981	prep	of,injection
R5586	T8984	T8985	nummod	30,mg
R5587	T8985	T8986	nmod	mg,calcein
R5588	T8986	T8983	pobj	calcein,of
R5589	T8987	T8988	punct	/,kg
R5590	T8988	T8985	prep	kg,mg
R5591	T8989	T8978	prep	at,given
R5592	T8990	T8991	nummod	7,days
R5593	T8991	T8989	pobj	days,at
R5594	T8992	T8978	cc	and,given
R5595	T8993	T8994	nummod	30,mg
R5596	T8994	T8995	nmod	mg,tetracycline
R5597	T8995	T8978	conj	tetracycline,given
R5598	T8996	T8997	punct	/,kg
R5599	T8997	T8994	prep	kg,mg
R5600	T8998	T8995	prep	at,tetracycline
R5601	T8999	T9000	nummod	2,days
R5602	T9000	T8998	pobj	days,at
R5603	T9001	T9002	amod	prior,to
R5604	T9002	T9000	prep	to,days
R5605	T9003	T9002	pobj	sacrifice,to
R5606	T9004	T9005	aux	to,label
R5607	T9005	T8978	advcl	label,given
R5608	T9006	T9007	advmod	actively,mineralizing
R5609	T9007	T9008	amod	mineralizing,surfaces
R5610	T9008	T9005	dobj	surfaces,label
R5611	T9009	T8978	punct	.,given
R5612	T9011	T9012	prep	After,embedded
R5613	T9013	T9014	advmod	overnight,fixation
R5614	T9014	T9011	pobj	fixation,After
R5615	T9015	T9014	prep	in,fixation
R5616	T9016	T9017	nummod	4,%
R5617	T9017	T9018	compound	%,paraformaldehyde
R5618	T9018	T9015	pobj	paraformaldehyde,in
R5619	T9019	T9014	cc	and,fixation
R5620	T9020	T9014	conj	rinsing,fixation
R5621	T9021	T9020	prep	in,rinsing
R5622	T9022	T9021	pobj	PBS,in
R5623	T9023	T9012	punct	", ",embedded
R5624	T9024	T9025	det	the,femur
R5625	T9025	T9012	nsubjpass	femur,embedded
R5626	T9026	T9025	amod	left,femur
R5627	T9027	T9025	cc	and,femur
R5628	T9028	T9025	conj	tibia,femur
R5629	T9029	T9012	auxpass	were,embedded
R5630	T9030	T9012	prep	in,embedded
R5631	T9031	T9030	pobj	polymethylmethacrylate,in
R5632	T9032	T9031	punct	(,polymethylmethacrylate
R5633	T9033	T9031	appos	MMA,polymethylmethacrylate
R5634	T9034	T9031	punct	),polymethylmethacrylate
R5635	T9035	T9031	cc	or,polymethylmethacrylate
R5636	T9036	T9037	det	a,mixture
R5637	T9037	T9031	conj	mixture,polymethylmethacrylate
R5638	T9038	T9037	prep	of,mixture
R5639	T9039	T9040	nummod	50,%
R5640	T9040	T9041	compound	%,MMA
R5641	T9041	T9038	pobj	MMA,of
R5642	T9042	T9041	cc	and,MMA
R5643	T9043	T9044	nummod	50,%
R5644	T9044	T9041	conj	%,MMA
R5645	T9045	T9044	appos	glycolmethacrylate,%
R5646	T9046	T9045	punct	(,glycolmethacrylate
R5647	T9047	T9045	appos	GMA,glycolmethacrylate
R5648	T9048	T9037	punct	),mixture
R5649	T9049	T9012	punct	.,embedded
R5650	T9051	T9052	amod	Serial,sections
R5651	T9052	T9059	nsubjpass	sections,left
R5652	T9053	T9054	quantmod	4,6
R5653	T9054	T9057	nummod	6,μm
R5654	T9055	T9054	punct	-,6
R5655	T9056	T9054	quantmod	to,6
R5656	T9057	T9052	compound	μm,sections
R5657	T9058	T9057	punct	-,μm
R5658	T9060	T9052	prep	of,sections
R5659	T9061	T9062	npadvmod	MMA,embedded
R5660	T9062	T9064	amod	embedded,tissues
R5661	T9063	T9062	punct	-,embedded
R5662	T9064	T9060	pobj	tissues,of
R5663	T9065	T9059	auxpass	were,left
R5664	T9066	T9059	oprd	unstained,left
R5665	T9067	T9059	cc	or,left
R5666	T9068	T9059	conj	stained,left
R5667	T9069	T9068	prep	with,stained
R5668	T9070	T9071	compound	von,Kossa
R5669	T9071	T9069	pobj	Kossa,with
R5670	T9072	T9071	cc	and,Kossa
R5671	T9073	T9074	compound	toluidine,blue
R5672	T9074	T9071	conj	blue,Kossa
R5673	T9075	T9069	cc	or,with
R5674	T9076	T9069	conj	with,with
R5675	T9077	T9078	compound	toluidine,blue
R5676	T9078	T9076	pobj	blue,with
R5677	T9079	T9078	advmod	alone,blue
R5678	T9080	T9059	punct	", ",left
R5679	T9081	T9082	mark	while,stained
R5680	T9082	T9059	advcl	stained,left
R5681	T9083	T9084	nummod	4,μm
R5682	T9084	T9086	compound	μm,sections
R5683	T9085	T9084	punct	-,μm
R5684	T9086	T9082	nsubjpass	sections,stained
R5685	T9087	T9088	compound	MMA,GMA
R5686	T9088	T9086	compound	GMA,sections
R5687	T9089	T9088	punct	-,GMA
R5688	T9090	T9082	auxpass	were,stained
R5689	T9091	T9082	prep	for,stained
R5690	T9092	T9093	nmod	TRAP,activity
R5691	T9093	T9091	pobj	activity,for
R5692	T9094	T9092	cc	and,TRAP
R5693	T9095	T9092	conj	ALP,TRAP
R5694	T9096	T9059	punct	.,left
R5695	T9098	T9099	nsubjpass	Images,captured
R5696	T9100	T9099	auxpass	were,captured
R5697	T9101	T9099	advcl	using,captured
R5698	T9102	T9103	det	a,microscope
R5699	T9103	T9101	dobj	microscope,using
R5700	T9104	T9105	compound	Leica,DMR
R5701	T9105	T9103	compound	DMR,microscope
R5702	T9106	T9107	punct	(,Microsystems
R5703	T9107	T9103	parataxis	Microsystems,microscope
R5704	T9108	T9107	compound	Leica,Microsystems
R5705	T9109	T9107	punct	),Microsystems
R5706	T9110	T9103	acl	equipped,microscope
R5707	T9111	T9110	prep	with,equipped
R5708	T9112	T9113	det	a,camera
R5709	T9113	T9111	pobj	camera,with
R5710	T9114	T9113	nmod	Retiga,camera
R5711	T9115	T9114	nummod	1300,Retiga
R5712	T9116	T9117	punct	(,Qimaging
R5713	T9117	T9113	parataxis	Qimaging,camera
R5714	T9118	T9117	punct	", ",Qimaging
R5715	T9119	T9117	npadvmod	Burnaby,Qimaging
R5716	T9120	T9117	punct	", ",Qimaging
R5717	T9121	T9122	compound	British,Columbia
R5718	T9122	T9117	npadvmod	Columbia,Qimaging
R5719	T9123	T9117	punct	", ",Qimaging
R5720	T9124	T9117	npadvmod	Canada,Qimaging
R5721	T9125	T9117	punct	),Qimaging
R5722	T9126	T9099	cc	and,captured
R5723	T9127	T9128	det	the,data
R5724	T9128	T9131	nsubj	data,obtained
R5725	T9129	T9128	amod	primary,data
R5726	T9130	T9128	amod	histomorphometric,data
R5727	T9131	T9099	conj	obtained,captured
R5728	T9132	T9131	advcl	using,obtained
R5729	T9133	T9134	compound	Bioquant,Prime
R5730	T9134	T9136	compound	Prime,software
R5731	T9135	T9134	compound	Nova,Prime
R5732	T9136	T9132	dobj	software,using
R5733	T9137	T9138	compound	image,analysis
R5734	T9138	T9136	compound	analysis,software
R5735	T9139	T9140	punct	(,Corp
R5736	T9140	T9136	parataxis	Corp,software
R5737	T9141	T9140	compound	Bioquant,Corp
R5738	T9142	T9143	compound	Image,Analysis
R5739	T9143	T9140	compound	Analysis,Corp
R5740	T9144	T9140	punct	", ",Corp
R5741	T9145	T9140	npadvmod	Nashville,Corp
R5742	T9146	T9140	punct	", ",Corp
R5743	T9147	T9140	npadvmod	Tennessee,Corp
R5744	T9148	T9140	punct	", ",Corp
R5745	T9149	T9150	compound	United,States
R5746	T9150	T9140	npadvmod	States,Corp
R5747	T9151	T9140	punct	),Corp
R5748	T9152	T9131	punct	.,obtained
R5749	T9154	T9155	nsubj	Nomenclature,conform
R5750	T9156	T9154	cc	and,Nomenclature
R5751	T9157	T9154	conj	abbreviations,Nomenclature
R5752	T9158	T9155	prep	to,conform
R5753	T9159	T9158	pobj	those,to
R5754	T9160	T9159	acl	recommended,those
R5755	T9161	T9160	agent	by,recommended
R5756	T9162	T9163	det	the,Society
R5757	T9163	T9161	pobj	Society,by
R5758	T9164	T9163	compound	American,Society
R5759	T9165	T9163	prep	for,Society
R5760	T9166	T9167	nmod	Bone,Research
R5761	T9167	T9165	pobj	Research,for
R5762	T9168	T9166	cc	and,Bone
R5763	T9169	T9166	conj	Mineral,Bone
R5764	T9170	T9171	punct	[,50
R5765	T9171	T9155	parataxis	50,conform
R5766	T9172	T9171	punct	],50
R5767	T9173	T9155	punct	.,conform
R5772	T9294	T9293	prep	of,Generation
R5773	T9295	T9294	pobj	mice,of
R5774	T9296	T9295	prep	with,mice
R5775	T9297	T9298	amod	targeted,disruption
R5776	T9298	T9296	pobj	disruption,with
R5777	T9299	T9298	prep	of,disruption
R5778	T9300	T9301	det	the,gene
R5779	T9301	T9299	pobj	gene,of
R5780	T9302	T9301	compound	sam68,gene
R5781	T9303	T9293	punct	.,Generation
R5782	T9305	T9306	det	A,clone
R5783	T9306	T9309	nsubjpass	clone,isolated
R5784	T9307	T9306	compound	λ,clone
R5785	T9308	T9306	compound	bacteriophage,clone
R5786	T9310	T9306	acl	encompassing,clone
R5787	T9311	T9312	nmod	Sam68,3
R5788	T9312	T9310	dobj	3,encompassing
R5789	T9313	T9312	nmod	exons,3
R5790	T9314	T9312	prep	to,3
R5791	T9315	T9314	pobj	9,to
R5792	T9316	T9309	auxpass	was,isolated
R5793	T9317	T9309	prep	from,isolated
R5794	T9318	T9319	det	a,library
R5795	T9319	T9317	pobj	library,from
R5796	T9320	T9321	nummod	129,SvJ
R5797	T9321	T9319	nmod	SvJ,library
R5798	T9322	T9321	punct	/,SvJ
R5799	T9323	T9319	amod	genomic,library
R5800	T9324	T9309	advcl	using,isolated
R5801	T9325	T9326	amod	full,length
R5802	T9326	T9328	compound	length,cDNA
R5803	T9327	T9326	punct	-,length
R5804	T9328	T9324	dobj	cDNA,using
R5805	T9329	T9328	compound	Sam68,cDNA
R5806	T9330	T9324	prep	as,using
R5807	T9331	T9332	det	a,probe
R5808	T9332	T9330	pobj	probe,as
R5809	T9333	T9309	punct	.,isolated
R5810	T9335	T9336	npadvmod	XbaI,digested
R5811	T9336	T9338	amod	digested,fragments
R5812	T9337	T9336	punct	-,digested
R5813	T9338	T9342	nsubjpass	fragments,subcloned
R5814	T9339	T9338	nmod	Sam68,fragments
R5815	T9340	T9338	amod	genomic,fragments
R5816	T9341	T9338	compound	DNA,fragments
R5817	T9343	T9338	prep	of,fragments
R5818	T9344	T9345	nummod	4,kb
R5819	T9345	T9343	pobj	kb,of
R5820	T9346	T9347	punct	(,encompassing
R5821	T9347	T9345	parataxis	encompassing,kb
R5822	T9348	T9347	dobj	exon,encompassing
R5823	T9349	T9348	nummod	4,exon
R5824	T9350	T9348	cc	and,exon
R5825	T9351	T9348	conj	part,exon
R5826	T9352	T9351	prep	of,part
R5827	T9353	T9352	pobj	exon,of
R5828	T9354	T9353	nummod	5,exon
R5829	T9355	T9347	punct	),encompassing
R5830	T9356	T9345	cc	and,kb
R5831	T9357	T9345	conj	3kb,kb
R5832	T9358	T9359	punct	(,spanning
R5833	T9359	T9357	parataxis	spanning,3kb
R5834	T9360	T9359	dobj	part,spanning
R5835	T9361	T9360	prep	of,part
R5836	T9362	T9361	pobj	exon,of
R5837	T9363	T9362	nummod	5,exon
R5838	T9364	T9360	cc	and,part
R5839	T9365	T9360	conj	exon,part
R5840	T9366	T9365	nummod	6,exon
R5841	T9367	T9359	punct	),spanning
R5842	T9368	T9342	auxpass	were,subcloned
R5843	T9369	T9342	prep	in,subcloned
R5844	T9370	T9371	compound	Bluescript,SK
R5845	T9371	T9369	pobj	SK,in
R5846	T9372	T9342	advcl	resulting,subcloned
R5847	T9373	T9372	prep	in,resulting
R5848	T9374	T9373	pobj	pBS4,in
R5849	T9375	T9374	cc	and,pBS4
R5850	T9376	T9374	conj	pBS3,pBS4
R5851	T9377	T9372	punct	", ",resulting
R5852	T9378	T9372	advmod	respectively,resulting
R5853	T9379	T9342	punct	.,subcloned
R5854	T9381	T9382	det	A,fragment
R5855	T9382	T9384	nsubjpass	fragment,amplified
R5856	T9383	T9382	compound	DNA,fragment
R5857	T9385	T9384	auxpass	was,amplified
R5858	T9386	T9384	prep	from,amplified
R5859	T9387	T9386	pobj	pBS4,from
R5860	T9388	T9384	prep	with,amplified
R5861	T9389	T9390	det	the,oligonucleotides
R5862	T9390	T9388	pobj	oligonucleotides,with
R5863	T9391	T9390	amod	following,oligonucleotides
R5864	T9392	T9393	punct	(,5
R5865	T9393	T9390	parataxis	5,oligonucleotides
R5866	T9394	T9393	punct	′,5
R5867	T9395	T9393	punct	-,5
R5868	T9396	T9397	compound	AAT,C
R5869	T9397	T9393	appos	C,5
R5870	T9398	T9397	compound	GTC,C
R5871	T9399	T9397	compound	TAG,C
R5872	T9400	T9397	compound	AAA,C
R5873	T9401	T9397	compound	CAA,C
R5874	T9402	T9397	compound	CTC,C
R5875	T9403	T9397	compound	ATA,C
R5876	T9404	T9397	compound	TAC,C
R5877	T9405	T9397	compound	AGA,C
R5878	T9406	T9393	punct	-,5
R5879	T9407	T9393	nummod	3,5
R5880	T9408	T9393	punct	′,5
R5881	T9409	T9393	punct	),5
R5882	T9410	T9390	cc	and,oligonucleotides
R5883	T9411	T9412	det	the,primer
R5884	T9412	T9390	conj	primer,oligonucleotides
R5885	T9413	T9412	amod	universal,primer
R5886	T9414	T9384	punct	.,amplified
R5887	T9416	T9417	det	The,fragment
R5888	T9417	T9425	nsubjpass	fragment,subcloned
R5889	T9418	T9419	npadvmod	XbaI,digested
R5890	T9419	T9417	amod	digested,fragment
R5891	T9420	T9419	punct	-,digested
R5892	T9421	T9422	nummod	1,kb
R5893	T9422	T9417	compound	kb,fragment
R5894	T9423	T9422	punct	-,kb
R5895	T9424	T9417	compound	DNA,fragment
R5896	T9426	T9425	auxpass	was,subcloned
R5897	T9427	T9425	prep	in,subcloned
R5898	T9428	T9429	det	the,site
R5899	T9429	T9427	pobj	site,in
R5900	T9430	T9429	compound	XbaI,site
R5901	T9431	T9429	prep	of,site
R5902	T9432	T9431	pobj	pPNT,of
R5903	T9433	T9434	punct	(,gift
R5904	T9434	T9432	parataxis	gift,pPNT
R5905	T9435	T9434	det	a,gift
R5906	T9436	T9434	prep	from,gift
R5907	T9437	T9438	compound	Andrew,Karaplis
R5908	T9438	T9436	pobj	Karaplis,from
R5909	T9439	T9438	punct	", ",Karaplis
R5910	T9440	T9441	compound	McGill,University
R5911	T9441	T9438	npadvmod	University,Karaplis
R5912	T9442	T9438	punct	", ",Karaplis
R5913	T9443	T9438	npadvmod	Montréal,Karaplis
R5914	T9444	T9438	punct	", ",Karaplis
R5915	T9445	T9438	npadvmod	Quebec,Karaplis
R5916	T9446	T9438	punct	", ",Karaplis
R5917	T9447	T9438	npadvmod	Canada,Karaplis
R5918	T9448	T9434	punct	),gift
R5919	T9449	T9425	punct	.,subcloned
R5920	T9451	T9452	det	The,fragment
R5921	T9452	T9456	nsubjpass	fragment,amplified
R5922	T9453	T9454	nummod	3,kb
R5923	T9454	T9452	compound	kb,fragment
R5924	T9455	T9454	punct	-,kb
R5925	T9457	T9452	prep	from,fragment
R5926	T9458	T9457	pobj	pBS3,from
R5927	T9459	T9456	auxpass	was,amplified
R5928	T9460	T9456	prep	by,amplified
R5929	T9461	T9460	pobj	PCR,by
R5930	T9462	T9461	prep	with,PCR
R5931	T9463	T9462	punct	(,with
R5932	T9464	T9462	pobj	5,with
R5933	T9465	T9464	punct	′,5
R5934	T9466	T9464	punct	-,5
R5935	T9467	T9468	compound	GGG,G
R5936	T9468	T9464	appos	G,5
R5937	T9469	T9468	compound	ATG,G
R5938	T9470	T9468	compound	CGG,G
R5939	T9471	T9468	compound	CCG,G
R5940	T9472	T9468	compound	CTC,G
R5941	T9473	T9468	compound	TAG,G
R5942	T9474	T9468	compound	AAT,G
R5943	T9475	T9468	compound	TGT,G
R5944	T9476	T9468	compound	CCT,G
R5945	T9477	T9468	compound	ACT,G
R5946	T9478	T9468	compound	TGA,G
R5947	T9479	T9468	compound	ACG,G
R5948	T9480	T9464	punct	-,5
R5949	T9481	T9464	nummod	3,5
R5950	T9482	T9464	punct	',5
R5951	T9483	T9464	punct	),5
R5952	T9484	T9464	cc	and,5
R5953	T9485	T9486	punct	(,5
R5954	T9486	T9464	conj	5,5
R5955	T9487	T9486	punct	′,5
R5956	T9488	T9486	punct	-,5
R5957	T9489	T9490	compound	CGG,A
R5958	T9490	T9486	appos	A,5
R5959	T9491	T9490	compound	TGG,A
R5960	T9492	T9490	compound	CGG,A
R5961	T9493	T9490	compound	CCG,A
R5962	T9494	T9490	compound	CTG,A
R5963	T9495	T9490	compound	TCG,A
R5964	T9496	T9490	compound	ACC,A
R5965	T9497	T9490	compound	TGA,A
R5966	T9498	T9490	compound	GTA,A
R5967	T9499	T9490	compound	ACA,A
R5968	T9500	T9490	compound	TTT,A
R5969	T9501	T9490	compound	CTT,A
R5970	T9502	T9486	punct	-,5
R5971	T9503	T9486	nummod	3,5
R5972	T9504	T9486	punct	′,5
R5973	T9505	T9456	punct	),amplified
R5974	T9506	T9456	cc	and,amplified
R5975	T9507	T9456	conj	subcloned,amplified
R5976	T9508	T9507	prep	in,subcloned
R5977	T9509	T9510	det	the,site
R5978	T9510	T9508	pobj	site,in
R5979	T9511	T9510	compound	NotI,site
R5980	T9512	T9510	prep	of,site
R5981	T9513	T9512	pobj	pPNT,of
R5982	T9514	T9456	punct	.,amplified
R5983	T9516	T9517	det	The,vector
R5984	T9517	T9519	nsubj	vector,replaces
R5985	T9518	T9517	compound	targeting,vector
R5986	T9520	T9521	compound	pPNT,Sam68
R5987	T9521	T9517	appos	Sam68,vector
R5988	T9522	T9521	punct	-,Sam68
R5989	T9523	T9519	dobj	exon,replaces
R5990	T9524	T9523	nummod	4,exon
R5991	T9525	T9523	cc	and,exon
R5992	T9526	T9523	conj	part,exon
R5993	T9527	T9526	prep	of,part
R5994	T9528	T9527	pobj	exon,of
R5995	T9529	T9528	nummod	5,exon
R5996	T9530	T9519	prep	with,replaces
R5997	T9531	T9532	det	a,cassette
R5998	T9532	T9530	pobj	cassette,with
R5999	T9533	T9534	npadvmod	neomycin,resistant
R6000	T9534	T9532	amod	resistant,cassette
R6001	T9535	T9534	punct	-,resistant
R6002	T9536	T9532	compound	gene,cassette
R6003	T9537	T9519	punct	.,replaces
R6004	T9539	T9540	det	An,site
R6005	T9540	T9542	nsubjpass	site,introduced
R6006	T9541	T9540	compound	SalI,site
R6007	T9543	T9542	auxpass	was,introduced
R6008	T9544	T9542	prep	at,introduced
R6009	T9545	T9546	det	the,end
R6010	T9546	T9544	pobj	end,at
R6011	T9547	T9546	nummod	3,end
R6012	T9548	T9547	punct	′,3
R6013	T9549	T9546	prep	of,end
R6014	T9550	T9551	det	the,fragment
R6015	T9551	T9549	pobj	fragment,of
R6016	T9552	T9553	nummod	3,kb
R6017	T9553	T9551	compound	kb,fragment
R6018	T9554	T9553	punct	-,kb
R6019	T9555	T9551	compound	DNA,fragment
R6020	T9556	T9542	cc	and,introduced
R6021	T9557	T9558	auxpass	was,used
R6022	T9558	T9542	conj	used,introduced
R6023	T9559	T9560	aux	to,linearize
R6024	T9560	T9558	advcl	linearize,used
R6025	T9561	T9562	det	the,plasmid
R6026	T9562	T9560	dobj	plasmid,linearize
R6027	T9563	T9560	prep	for,linearize
R6028	T9564	T9563	pobj	electroporation,for
R6029	T9565	T9564	prep	into,electroporation
R6030	T9566	T9567	amod	embryonic,stem
R6031	T9567	T9568	nmod	stem,cells
R6032	T9568	T9565	pobj	cells,into
R6033	T9569	T9567	punct	(,stem
R6034	T9570	T9567	appos	ES,stem
R6035	T9571	T9568	punct	),cells
R6036	T9572	T9542	punct	.,introduced
R6037	T9574	T9575	advmod	Approximately,"1,000"
R6038	T9575	T9576	nummod	"1,000",colonies
R6039	T9576	T9578	nsubjpass	colonies,screened
R6040	T9577	T9576	compound	ES,colonies
R6041	T9579	T9578	auxpass	were,screened
R6042	T9580	T9578	cc	and,screened
R6043	T9581	T9582	nummod	two,clones
R6044	T9582	T9583	nsubjpass	clones,identified
R6045	T9583	T9578	conj	identified,screened
R6046	T9584	T9583	auxpass	were,identified
R6047	T9585	T9586	dep	that,contained
R6048	T9586	T9583	ccomp	contained,identified
R6049	T9587	T9588	det	the,Sam68
R6050	T9588	T9589	compound	Sam68,allele
R6051	T9589	T9586	dobj	allele,contained
R6052	T9590	T9589	compound	mutant,allele
R6053	T9591	T9583	punct	", ",identified
R6054	T9592	T9593	mark	as,determined
R6055	T9593	T9583	advcl	determined,identified
R6056	T9594	T9593	prep	by,determined
R6057	T9595	T9596	compound	Southern,blotting
R6058	T9596	T9594	pobj	blotting,by
R6059	T9597	T9583	punct	.,identified
R6060	T9599	T9600	amod	Targeted,cells
R6061	T9600	T9602	nsubjpass	cells,injected
R6062	T9601	T9600	compound	ES,cells
R6063	T9603	T9602	auxpass	were,injected
R6064	T9604	T9602	prep	into,injected
R6065	T9605	T9606	nummod	3.5,day
R6066	T9606	T9608	npadvmod	day,old
R6067	T9607	T9606	punct	-,day
R6068	T9608	T9610	amod	old,blastocysts
R6069	T9609	T9608	punct	-,old
R6070	T9610	T9604	pobj	blastocysts,into
R6071	T9611	T9612	compound	BALB,c
R6072	T9612	T9610	compound	c,blastocysts
R6073	T9613	T9612	punct	/,c
R6074	T9614	T9602	cc	and,injected
R6075	T9615	T9616	auxpass	were,transferred
R6076	T9616	T9602	conj	transferred,injected
R6077	T9617	T9616	prep	into,transferred
R6078	T9618	T9619	nmod	CD,mothers
R6079	T9619	T9617	pobj	mothers,into
R6080	T9620	T9618	punct	-,CD
R6081	T9621	T9618	nummod	1,CD
R6082	T9622	T9619	compound	foster,mothers
R6083	T9623	T9602	punct	", ",injected
R6084	T9624	T9602	cc	and,injected
R6085	T9625	T9626	nsubjpass	animals,mated
R6086	T9626	T9602	conj	mated,injected
R6087	T9627	T9625	acl	classified,animals
R6088	T9628	T9627	prep	as,classified
R6089	T9629	T9628	pobj	chimeras,as
R6090	T9630	T9627	prep	by,classified
R6091	T9631	T9632	compound	coat,color
R6092	T9632	T9630	pobj	color,by
R6093	T9633	T9626	auxpass	were,mated
R6094	T9634	T9626	prep	with,mated
R6095	T9635	T9636	compound	BALB,c
R6096	T9636	T9638	compound	c,mice
R6097	T9637	T9636	punct	/,c
R6098	T9638	T9634	pobj	mice,with
R6099	T9639	T9626	punct	.,mated
R6100	T9641	T9642	compound	Germ,line
R6101	T9642	T9643	compound	line,transmission
R6102	T9643	T9644	nsubjpass	transmission,achieved
R6103	T9645	T9644	auxpass	was,achieved
R6104	T9646	T9644	cc	and,achieved
R6105	T9647	T9648	det	the,mice
R6106	T9648	T9649	nsubjpass	mice,maintained
R6107	T9649	T9644	conj	maintained,achieved
R6108	T9650	T9649	auxpass	were,maintained
R6109	T9651	T9649	prep	in,maintained
R6110	T9652	T9653	nmod	C57BL,background
R6111	T9653	T9651	pobj	background,in
R6112	T9654	T9652	punct	/,C57BL
R6113	T9655	T9652	nummod	6,C57BL
R6114	T9656	T9649	punct	.,maintained
R6115	T9658	T9659	det	The,mice
R6116	T9659	T9660	nsubj	mice,represent
R6117	T9660	T9665	ccomp	represent,maintained
R6118	T9661	T9659	acl	used,mice
R6119	T9662	T9661	prep	for,used
R6120	T9663	T9664	det	this,study
R6121	T9664	T9662	pobj	study,for
R6122	T9666	T9660	dobj	mice,represent
R6123	T9667	T9668	dep	that,backcrossed
R6124	T9668	T9666	relcl	backcrossed,mice
R6125	T9669	T9668	auxpass	were,backcrossed
R6126	T9670	T9668	prep	in,backcrossed
R6127	T9671	T9670	pobj	C57BL,in
R6128	T9672	T9671	punct	/,C57BL
R6129	T9673	T9671	nummod	6,C57BL
R6130	T9674	T9675	quantmod	between,three
R6131	T9675	T9676	nummod	three,generations
R6132	T9676	T9668	npadvmod	generations,backcrossed
R6133	T9677	T9675	cc	and,three
R6134	T9678	T9675	conj	eight,three
R6135	T9679	T9665	punct	;,maintained
R6136	T9680	T9665	prep	in,maintained
R6137	T9681	T9680	pobj	addition,in
R6138	T9682	T9665	punct	", ",maintained
R6139	T9683	T9665	nsubj	we,maintained
R6140	T9684	T9685	det	the,mice
R6141	T9685	T9665	dobj	mice,maintained
R6142	T9686	T9685	prep	in,mice
R6143	T9687	T9688	det	the,strain
R6144	T9688	T9686	pobj	strain,in
R6145	T9689	T9690	nummod	129,SvJ
R6146	T9690	T9688	compound	SvJ,strain
R6147	T9691	T9690	punct	/,SvJ
R6148	T9692	T9665	cc	and,maintained
R6149	T9693	T9665	conj	observed,maintained
R6150	T9694	T9695	det	a,phenotype
R6151	T9695	T9693	dobj	phenotype,observed
R6152	T9696	T9695	amod	similar,phenotype
R6153	T9697	T9665	punct	.,maintained
R6154	T9733	T9732	cc	and,Genotyping
R6155	T9734	T9735	compound	immunoblot,analyses
R6156	T9735	T9732	conj	analyses,Genotyping
R6157	T9736	T9735	punct	.,analyses
R6158	T9738	T9739	det	All,procedures
R6159	T9739	T9741	nsubjpass	procedures,performed
R6160	T9740	T9739	compound	mouse,procedures
R6161	T9742	T9741	auxpass	were,performed
R6162	T9743	T9741	prep	in,performed
R6163	T9744	T9743	pobj	accordance,in
R6164	T9745	T9744	prep	with,accordance
R6165	T9746	T9747	compound	McGill,University
R6166	T9747	T9748	compound	University,guidelines
R6167	T9748	T9745	pobj	guidelines,with
R6168	T9749	T9748	punct	", ",guidelines
R6169	T9750	T9751	dep	which,set
R6170	T9751	T9748	relcl	set,guidelines
R6171	T9752	T9751	auxpass	are,set
R6172	T9753	T9751	agent	by,set
R6173	T9754	T9755	det	the,Council
R6174	T9755	T9753	pobj	Council,by
R6175	T9756	T9755	compound	Canadian,Council
R6176	T9757	T9755	prep	on,Council
R6177	T9758	T9759	compound	Animal,Care
R6178	T9759	T9757	pobj	Care,on
R6179	T9760	T9741	punct	.,performed
R6180	T9762	T9763	amod	Genomic,DNA
R6181	T9763	T9764	nsubjpass	DNA,isolated
R6182	T9765	T9764	auxpass	was,isolated
R6183	T9766	T9764	prep	from,isolated
R6184	T9767	T9768	compound	tail,biopsies
R6185	T9768	T9766	pobj	biopsies,from
R6186	T9769	T9764	cc	and,isolated
R6187	T9770	T9764	conj	analyzed,isolated
R6188	T9771	T9770	prep	by,analyzed
R6189	T9772	T9773	compound	Southern,blotting
R6190	T9773	T9771	pobj	blotting,by
R6191	T9774	T9773	cc	and,blotting
R6192	T9775	T9776	amod	genomic,analysis
R6193	T9776	T9773	conj	analysis,blotting
R6194	T9777	T9776	compound	PCR,analysis
R6195	T9778	T9764	punct	.,isolated
R6196	T9780	T9781	det	The,fragment
R6197	T9781	T9783	nsubjpass	fragment,amplified
R6198	T9782	T9781	compound	DNA,fragment
R6199	T9784	T9781	acl	utilized,fragment
R6200	T9785	T9784	prep	as,utilized
R6201	T9786	T9787	det	the,probe
R6202	T9787	T9785	pobj	probe,as
R6203	T9788	T9787	prep	for,probe
R6204	T9789	T9790	det	the,analysis
R6205	T9790	T9788	pobj	analysis,for
R6206	T9791	T9792	compound	Southern,blotting
R6207	T9792	T9790	compound	blotting,analysis
R6208	T9793	T9783	auxpass	was,amplified
R6209	T9794	T9783	prep	with,amplified
R6210	T9795	T9796	det	the,oligonucleotides
R6211	T9796	T9794	pobj	oligonucleotides,with
R6212	T9797	T9796	amod	following,oligonucleotides
R6213	T9798	T9796	nummod	two,oligonucleotides
R6214	T9799	T9796	punct	(,oligonucleotides
R6215	T9800	T9796	appos	5,oligonucleotides
R6216	T9801	T9800	punct	′,5
R6217	T9802	T9800	punct	-,5
R6218	T9803	T9804	compound	AAG,T
R6219	T9804	T9800	appos	T,5
R6220	T9805	T9804	compound	CCT,T
R6221	T9806	T9804	compound	TTA,T
R6222	T9807	T9804	compound	CTG,T
R6223	T9808	T9804	compound	GTT,T
R6224	T9809	T9804	compound	GTG,T
R6225	T9810	T9800	punct	-,5
R6226	T9811	T9800	nummod	3,5
R6227	T9812	T9800	punct	′,5
R6228	T9813	T9800	punct	),5
R6229	T9814	T9800	cc	and,5
R6230	T9815	T9816	punct	(,5
R6231	T9816	T9800	conj	5,5
R6232	T9817	T9816	punct	′,5
R6233	T9818	T9816	punct	-,5
R6234	T9819	T9820	compound	CTT,CT
R6235	T9820	T9816	appos	CT,5
R6236	T9821	T9820	compound	GAA,CT
R6237	T9822	T9820	compound	ACG,CT
R6238	T9823	T9820	compound	CAC,CT
R6239	T9824	T9820	compound	CGT,CT
R6240	T9825	T9820	compound	AGG,CT
R6241	T9826	T9816	punct	-,5
R6242	T9827	T9816	nummod	3,5
R6243	T9828	T9816	punct	′,5
R6244	T9829	T9783	punct	),amplified
R6245	T9830	T9783	punct	.,amplified
R6246	T9832	T9833	det	The,allele
R6247	T9833	T9838	nsubjpass	allele,identified
R6248	T9834	T9835	amod	wild,type
R6249	T9835	T9833	compound	type,allele
R6250	T9836	T9835	punct	-,type
R6251	T9837	T9833	compound	sam68,allele
R6252	T9839	T9838	auxpass	was,identified
R6253	T9840	T9838	prep	by,identified
R6254	T9841	T9842	amod	genomic,PCR
R6255	T9842	T9840	pobj	PCR,by
R6256	T9843	T9838	advcl	using,identified
R6257	T9844	T9845	det	the,oligonucleotides
R6258	T9845	T9843	dobj	oligonucleotides,using
R6259	T9846	T9845	amod	following,oligonucleotides
R6260	T9847	T9845	appos	5,oligonucleotides
R6261	T9848	T9847	punct	′,5
R6262	T9849	T9847	punct	-,5
R6263	T9850	T9851	compound	AAA,AG
R6264	T9851	T9847	appos	AG,5
R6265	T9852	T9851	compound	TCC,AG
R6266	T9853	T9851	compound	TAA,AG
R6267	T9854	T9851	compound	CCC,AG
R6268	T9855	T9851	compound	TCC,AG
R6269	T9856	T9851	compound	TCA,AG
R6270	T9857	T9851	compound	GTC,AG
R6271	T9858	T9847	punct	-,5
R6272	T9859	T9847	nummod	3,5
R6273	T9860	T9847	punct	′,5
R6274	T9861	T9847	cc	and,5
R6275	T9862	T9847	conj	5,5
R6276	T9863	T9862	punct	′,5
R6277	T9864	T9862	punct	-,5
R6278	T9865	T9866	compound	GAT,CAG
R6279	T9866	T9862	appos	CAG,5
R6280	T9867	T9866	compound	ATG,CAG
R6281	T9868	T9866	compound	ATG,CAG
R6282	T9869	T9866	compound	GAT,CAG
R6283	T9870	T9866	compound	GAT,CAG
R6284	T9871	T9866	compound	ATC,CAG
R6285	T9872	T9866	compound	TGT,CAG
R6286	T9873	T9862	punct	-,5
R6287	T9874	T9862	nummod	3,5
R6288	T9875	T9862	punct	′,5
R6289	T9876	T9838	punct	.,identified
R6290	T9878	T9879	det	The,allele
R6291	T9879	T9883	nsubjpass	allele,identified
R6292	T9880	T9881	npadvmod	sam68,targeted
R6293	T9881	T9879	amod	targeted,allele
R6294	T9882	T9881	punct	-,targeted
R6295	T9884	T9883	auxpass	was,identified
R6296	T9885	T9883	prep	by,identified
R6297	T9886	T9887	amod	genomic,PCR
R6298	T9887	T9885	pobj	PCR,by
R6299	T9888	T9883	advcl	using,identified
R6300	T9889	T9890	det	the,oligonucleotides
R6301	T9890	T9888	dobj	oligonucleotides,using
R6302	T9891	T9890	amod	following,oligonucleotides
R6303	T9892	T9890	appos	5,oligonucleotides
R6304	T9893	T9892	punct	′,5
R6305	T9894	T9892	punct	-,5
R6306	T9895	T9896	compound	CTT,TCG
R6307	T9896	T9892	appos	TCG,5
R6308	T9897	T9896	compound	GGG,TCG
R6309	T9898	T9896	compound	TGG,TCG
R6310	T9899	T9896	compound	AGA,TCG
R6311	T9900	T9896	compound	GGC,TCG
R6312	T9901	T9896	compound	TAT,TCG
R6313	T9902	T9892	punct	-,5
R6314	T9903	T9892	nummod	3,5
R6315	T9904	T9892	punct	′,5
R6316	T9905	T9892	cc	and,5
R6317	T9906	T9892	conj	5,5
R6318	T9907	T9906	punct	′,5
R6319	T9908	T9906	punct	-,5
R6320	T9909	T9910	compound	GTC,C
R6321	T9910	T9906	appos	C,5
R6322	T9911	T9910	compound	GGG,C
R6323	T9912	T9910	compound	CAT,C
R6324	T9913	T9910	compound	GCG,C
R6325	T9914	T9910	compound	CGC,C
R6326	T9915	T9910	compound	CTT,C
R6327	T9916	T9910	compound	GAG,C
R6328	T9917	T9906	punct	-,5
R6329	T9918	T9906	nummod	3,5
R6330	T9919	T9906	punct	′,5
R6331	T9920	T9883	punct	.,identified
R6332	T9979	T9978	cc	and,Radiology
R6333	T9980	T9981	compound	serum,biochemistry
R6334	T9981	T9978	conj	biochemistry,Radiology
R6335	T9982	T9978	prep	on,Radiology
R6336	T9983	T9984	nmod	Sam68,mice
R6337	T9984	T9982	pobj	mice,on
R6338	T9985	T9983	punct	+,Sam68
R6339	T9986	T9983	punct	/,Sam68
R6340	T9987	T9983	punct	+,Sam68
R6341	T9988	T9983	cc	and,Sam68
R6342	T9989	T9983	conj	Sam68,Sam68
R6343	T9990	T9989	punct	−,Sam68
R6344	T9991	T9989	punct	/,Sam68
R6345	T9992	T9989	punct	−,Sam68
R6346	T9993	T9978	punct	.,Radiology
R6347	T9995	T9996	nsubjpass	Radiography,performed
R6348	T9997	T9995	punct	", ",Radiography
R6349	T9998	T9995	conj	BMD,Radiography
R6350	T9999	T9998	punct	", ",BMD
R6351	T10000	T9998	cc	and,BMD
R6352	T10001	T9998	conj	micro-CT,BMD
R6353	T10002	T9996	auxpass	were,performed
R6354	T10003	T10004	advmod	essentially,described
R6355	T10004	T9996	advcl	described,performed
R6356	T10005	T10004	mark	as,described
R6357	T10006	T10004	advmod	previously,described
R6358	T10007	T10008	punct	[,63
R6359	T10008	T9996	parataxis	63,performed
R6360	T10009	T10008	punct	],63
R6361	T10010	T9996	punct	.,performed
R6362	T10012	T10013	nsubjpass	Mice,administered
R6363	T10014	T10013	auxpass	were,administered
R6364	T10015	T10016	det	a,dose
R6365	T10016	T10013	dobj	dose,administered
R6366	T10017	T10016	amod	lethal,dose
R6367	T10018	T10016	prep	of,dose
R6368	T10019	T10018	pobj	anesthetic,of
R6369	T10020	T10013	prep	at,administered
R6370	T10021	T10022	det	the,times
R6371	T10022	T10020	pobj	times,at
R6372	T10023	T10022	amod	indicated,times
R6373	T10024	T10013	punct	", ",administered
R6374	T10025	T10013	conj	exsanguinated,administered
R6375	T10026	T10025	punct	", ",exsanguinated
R6376	T10027	T10025	cc	and,exsanguinated
R6377	T10028	T10025	conj	imaged,exsanguinated
R6378	T10029	T10028	advcl	using,imaged
R6379	T10030	T10031	det	a,MX20
R6380	T10031	T10029	dobj	MX20,using
R6381	T10032	T10031	compound	Faxitron,MX20
R6382	T10033	T10031	acl	equipped,MX20
R6383	T10034	T10033	prep	with,equipped
R6384	T10035	T10036	det	an,system
R6385	T10036	T10034	pobj	system,with
R6386	T10037	T10036	nmod	FPX,system
R6387	T10038	T10037	punct	-,FPX
R6388	T10039	T10037	nummod	2,FPX
R6389	T10040	T10036	compound	Imaging,system
R6390	T10041	T10042	punct	(,Medoptics
R6391	T10042	T10031	parataxis	Medoptics,MX20
R6392	T10043	T10042	compound	Dalsa,Medoptics
R6393	T10044	T10042	punct	", ",Medoptics
R6394	T10045	T10042	npadvmod	Waterloo,Medoptics
R6395	T10046	T10042	punct	", ",Medoptics
R6396	T10047	T10042	npadvmod	Ontario,Medoptics
R6397	T10048	T10042	punct	", ",Medoptics
R6398	T10049	T10042	npadvmod	Canada,Medoptics
R6399	T10050	T10042	punct	),Medoptics
R6400	T10051	T10013	punct	.,administered
R6401	T10053	T10054	compound	Body,fat
R6402	T10054	T10055	nsubjpass	fat,evaluated
R6403	T10056	T10054	punct	", ",fat
R6404	T10057	T10054	conj	BMC,fat
R6405	T10058	T10057	punct	", ",BMC
R6406	T10059	T10057	cc	and,BMC
R6407	T10060	T10057	conj	BMD,BMC
R6408	T10061	T10055	auxpass	were,evaluated
R6409	T10062	T10055	advcl	using,evaluated
R6410	T10063	T10064	det	a,PixiMUS
R6411	T10064	T10062	dobj	PixiMUS,using
R6412	T10065	T10064	compound	Lunar,PixiMUS
R6413	T10066	T10064	nummod	1.46,PixiMUS
R6414	T10067	T10068	punct	(,Lunar
R6415	T10068	T10064	parataxis	Lunar,PixiMUS
R6416	T10069	T10068	compound	GE,Lunar
R6417	T10070	T10068	punct	-,Lunar
R6418	T10071	T10068	punct	", ",Lunar
R6419	T10072	T10068	npadvmod	Madison,Lunar
R6420	T10073	T10068	punct	", ",Lunar
R6421	T10074	T10068	npadvmod	Wisconsin,Lunar
R6422	T10075	T10068	punct	", ",Lunar
R6423	T10076	T10077	compound	United,States
R6424	T10077	T10068	npadvmod	States,Lunar
R6425	T10078	T10068	punct	),Lunar
R6426	T10079	T10055	punct	.,evaluated
R6427	T10081	T10082	amod	Morphometric,parameters
R6428	T10082	T10083	nsubjpass	parameters,determined
R6429	T10084	T10083	auxpass	were,determined
R6430	T10085	T10083	prep	on,determined
R6431	T10086	T10087	amod	anesthetized,mice
R6432	T10087	T10085	pobj	mice,on
R6433	T10088	T10083	prep	at,determined
R6434	T10089	T10090	det	the,time
R6435	T10090	T10088	pobj	time,at
R6436	T10091	T10090	prep	of,time
R6437	T10092	T10091	pobj	sacrifice,of
R6438	T10093	T10083	prep	by,determined
R6439	T10094	T10095	amod	direct,measurement
R6440	T10095	T10093	pobj	measurement,by
R6441	T10096	T10093	cc	or,by
R6442	T10097	T10093	conj	from,by
R6443	T10098	T10099	det	the,radiograph
R6444	T10099	T10097	pobj	radiograph,from
R6445	T10100	T10099	compound	Faxitron,radiograph
R6446	T10101	T10083	punct	.,determined
R6447	T10103	T10104	nsubjpass	Micro-CT,performed
R6448	T10105	T10104	auxpass	was,performed
R6449	T10106	T10104	prep	on,performed
R6450	T10107	T10108	det	the,femur
R6451	T10108	T10106	pobj	femur,on
R6452	T10109	T10108	amod	left,femur
R6453	T10110	T10108	cc	and,femur
R6454	T10111	T10112	amod	fourth,vertebra
R6455	T10112	T10108	conj	vertebra,femur
R6456	T10113	T10112	compound	lumbar,vertebra
R6457	T10114	T10104	prep	after,performed
R6458	T10115	T10114	pobj	removal,after
R6459	T10116	T10115	prep	of,removal
R6460	T10117	T10118	amod	soft,tissues
R6461	T10118	T10116	pobj	tissues,of
R6462	T10119	T10115	cc	and,removal
R6463	T10120	T10121	amod	overnight,fixation
R6464	T10121	T10115	conj	fixation,removal
R6465	T10122	T10121	prep	in,fixation
R6466	T10123	T10124	nummod	4,%
R6467	T10124	T10125	compound	%,paraformaldehyde
R6468	T10125	T10122	pobj	paraformaldehyde,in
R6469	T10126	T10104	punct	.,performed
R6470	T10128	T10129	det	The,metaphysis
R6471	T10129	T10131	nsubjpass	metaphysis,scanned
R6472	T10130	T10129	amod	distal,metaphysis
R6473	T10132	T10131	auxpass	was,scanned
R6474	T10133	T10131	prep	with,scanned
R6475	T10134	T10135	det	a,instrument
R6476	T10135	T10133	pobj	instrument,with
R6477	T10136	T10135	nmod	Skyscan,instrument
R6478	T10137	T10136	nummod	1072,Skyscan
R6479	T10138	T10135	compound	micro-CT,instrument
R6480	T10139	T10140	punct	(,Skyscan
R6481	T10140	T10135	parataxis	Skyscan,instrument
R6482	T10141	T10140	punct	", ",Skyscan
R6483	T10142	T10140	npadvmod	Antwerp,Skyscan
R6484	T10143	T10140	punct	", ",Skyscan
R6485	T10144	T10140	npadvmod	Belgium,Skyscan
R6486	T10145	T10140	punct	),Skyscan
R6487	T10146	T10131	punct	.,scanned
R6488	T10148	T10149	compound	Image,acquisition
R6489	T10149	T10150	nsubjpass	acquisition,performed
R6490	T10151	T10150	auxpass	was,performed
R6491	T10152	T10150	prep	at,performed
R6492	T10153	T10154	nummod	100,kV
R6493	T10154	T10152	pobj	kV,at
R6494	T10155	T10154	cc	and,kV
R6495	T10156	T10157	nummod	98,μA
R6496	T10157	T10154	conj	μA,kV
R6497	T10158	T10150	punct	", ",performed
R6498	T10159	T10150	prep	with,performed
R6499	T10160	T10161	det	a,rotation
R6500	T10161	T10159	pobj	rotation,with
R6501	T10162	T10163	nummod	0.9,°
R6502	T10163	T10161	compound	°,rotation
R6503	T10164	T10161	prep	between,rotation
R6504	T10165	T10164	pobj	frames,between
R6505	T10166	T10150	punct	.,performed
R6506	T10168	T10169	det	The,images
R6507	T10169	T10173	nsubjpass	images,used
R6508	T10170	T10171	advmod	two,dimensional
R6509	T10171	T10169	amod	dimensional,images
R6510	T10172	T10171	punct	-,dimensional
R6511	T10174	T10173	auxpass	were,used
R6512	T10175	T10176	aux	to,generate
R6513	T10176	T10173	advcl	generate,used
R6514	T10177	T10178	advmod	three,dimensional
R6515	T10178	T10180	amod	dimensional,reconstructions
R6516	T10179	T10178	punct	-,dimensional
R6517	T10180	T10176	dobj	reconstructions,generate
R6518	T10181	T10182	aux	to,obtain
R6519	T10182	T10176	advcl	obtain,generate
R6520	T10183	T10184	amod	quantitative,data
R6521	T10184	T10182	dobj	data,obtain
R6522	T10185	T10182	prep	with,obtain
R6523	T10186	T10187	det	the,software
R6524	T10187	T10185	pobj	software,with
R6525	T10188	T10189	amod	3D,Creator
R6526	T10189	T10187	compound	Creator,software
R6527	T10190	T10187	acl	supplied,software
R6528	T10191	T10190	prep	with,supplied
R6529	T10192	T10193	det	the,instrument
R6530	T10193	T10191	pobj	instrument,with
R6531	T10194	T10173	punct	.,used
R6532	T10196	T10197	compound	Serum,biochemistry
R6533	T10197	T10198	nsubjpass	biochemistry,determined
R6534	T10199	T10200	punct	(,Mg
R6535	T10200	T10197	parataxis	Mg,biochemistry
R6536	T10201	T10200	nmod	ALP,Mg
R6537	T10202	T10200	punct	", ",Mg
R6538	T10203	T10200	nmod	Ca,Mg
R6539	T10204	T10200	punct	", ",Mg
R6540	T10205	T10200	nmod	PO4,Mg
R6541	T10206	T10200	punct	", ",Mg
R6542	T10207	T10200	punct	),Mg
R6543	T10208	T10198	auxpass	was,determined
R6544	T10209	T10198	prep	at,determined
R6545	T10210	T10211	det	the,Lab
R6546	T10211	T10209	pobj	Lab,at
R6547	T10212	T10211	compound	Rodent,Lab
R6548	T10213	T10211	compound	Diagnostics,Lab
R6549	T10214	T10215	punct	(,University
R6550	T10215	T10211	parataxis	University,Lab
R6551	T10216	T10215	compound	McGill,University
R6552	T10217	T10215	punct	", ",University
R6553	T10218	T10215	npadvmod	Montréal,University
R6554	T10219	T10215	punct	", ",University
R6555	T10220	T10215	npadvmod	Quebec,University
R6556	T10221	T10215	punct	", ",University
R6557	T10222	T10215	npadvmod	Canada,University
R6558	T10223	T10215	punct	),University
R6559	T10224	T10198	advcl	using,determined
R6560	T10225	T10226	amod	routine,techniques
R6561	T10226	T10224	dobj	techniques,using
R6562	T10227	T10226	amod	automated,techniques
R6563	T10228	T10198	punct	.,determined
R6564	T10230	T10231	amod	Commercial,assays
R6565	T10231	T10232	nsubjpass	assays,used
R6566	T10233	T10232	auxpass	were,used
R6567	T10234	T10235	aux	to,determine
R6568	T10235	T10232	advcl	determine,used
R6569	T10236	T10237	compound	serum,levels
R6570	T10237	T10235	dobj	levels,determine
R6571	T10238	T10237	prep	of,levels
R6572	T10239	T10238	pobj	CTX,of
R6573	T10240	T10241	punct	(,ELISA
R6574	T10241	T10239	parataxis	ELISA,CTX
R6575	T10242	T10241	compound	RatLaps,ELISA
R6576	T10243	T10241	punct	", ",ELISA
R6577	T10244	T10245	compound	Nordic,Bioscience
R6578	T10245	T10241	appos	Bioscience,ELISA
R6579	T10246	T10241	punct	),ELISA
R6580	T10247	T10232	punct	", ",used
R6581	T10248	T10249	nummod	17β,estradiol
R6582	T10249	T10232	dep	estradiol,used
R6583	T10250	T10251	punct	(,Immuno-Biological
R6584	T10251	T10249	parataxis	Immuno-Biological,estradiol
R6585	T10252	T10251	compound	IBL,Immuno-Biological
R6586	T10253	T10251	punct	", ",Immuno-Biological
R6587	T10254	T10251	npadvmod	Hamburg,Immuno-Biological
R6588	T10255	T10251	punct	", ",Immuno-Biological
R6589	T10256	T10251	npadvmod	Germany,Immuno-Biological
R6590	T10257	T10251	punct	),Immuno-Biological
R6591	T10258	T10249	punct	", ",estradiol
R6592	T10259	T10249	conj	leptin,estradiol
R6593	T10260	T10261	punct	(,Systems
R6594	T10261	T10259	parataxis	Systems,leptin
R6595	T10262	T10261	nmod	R,Systems
R6596	T10263	T10262	cc	&,R
R6597	T10264	T10262	conj	D,R
R6598	T10265	T10261	punct	", ",Systems
R6599	T10266	T10261	npadvmod	Minneapolis,Systems
R6600	T10267	T10261	punct	", ",Systems
R6601	T10268	T10261	npadvmod	Minnesota,Systems
R6602	T10269	T10261	punct	", ",Systems
R6603	T10270	T10271	compound	United,States
R6604	T10271	T10261	npadvmod	States,Systems
R6605	T10272	T10261	punct	),Systems
R6606	T10273	T10259	punct	", ",leptin
R6607	T10274	T10259	cc	and,leptin
R6608	T10275	T10259	conj	interleukin,leptin
R6609	T10276	T10275	punct	-,interleukin
R6610	T10277	T10275	nummod	6,interleukin
R6611	T10278	T10279	punct	(,Systems
R6612	T10279	T10275	parataxis	Systems,interleukin
R6613	T10280	T10279	nmod	R,Systems
R6614	T10281	T10280	cc	&,R
R6615	T10282	T10280	conj	D,R
R6616	T10283	T10279	punct	),Systems
R6617	T10284	T10232	punct	.,used
R6618	T10388	T10389	advmod	Ex,vivo
R6619	T10389	T10390	amod	vivo,assessment
R6620	T10391	T10390	prep	of,assessment
R6621	T10392	T10393	nmod	osteoblast,activity
R6622	T10393	T10391	pobj	activity,of
R6623	T10394	T10392	cc	and,osteoblast
R6624	T10395	T10392	conj	osteoclast,osteoblast
R6625	T10396	T10390	punct	.,assessment
R6626	T10398	T10399	compound	Bone,marrow
R6627	T10399	T10400	nsubjpass	marrow,flushed
R6628	T10401	T10400	auxpass	was,flushed
R6629	T10402	T10400	prep	from,flushed
R6630	T10403	T10404	det	the,tibia
R6631	T10404	T10402	pobj	tibia,from
R6632	T10405	T10404	cc	and,tibia
R6633	T10406	T10404	conj	femora,tibia
R6634	T10407	T10404	prep	of,tibia
R6635	T10408	T10409	amod	juvenile,mice
R6636	T10409	T10407	pobj	mice,of
R6637	T10410	T10411	nummod	4,week
R6638	T10411	T10413	npadvmod	week,old
R6639	T10412	T10411	punct	-,week
R6640	T10413	T10409	amod	old,mice
R6641	T10414	T10413	punct	-,old
R6642	T10415	T10409	nmod	Sam68,mice
R6643	T10416	T10415	punct	+,Sam68
R6644	T10417	T10415	punct	/,Sam68
R6645	T10418	T10415	punct	+,Sam68
R6646	T10419	T10415	cc	and,Sam68
R6647	T10420	T10415	conj	Sam68,Sam68
R6648	T10421	T10420	punct	−,Sam68
R6649	T10422	T10420	punct	/,Sam68
R6650	T10423	T10420	punct	−,Sam68
R6651	T10424	T10425	aux	to,obtain
R6652	T10425	T10400	advcl	obtain,flushed
R6653	T10426	T10427	amod	stromal,cells
R6654	T10427	T10425	dobj	cells,obtain
R6655	T10428	T10429	dep	that,maintained
R6656	T10429	T10427	relcl	maintained,cells
R6657	T10430	T10429	auxpass	were,maintained
R6658	T10431	T10429	prep	in,maintained
R6659	T10432	T10433	compound	differentiation,medium
R6660	T10433	T10431	pobj	medium,in
R6661	T10434	T10400	prep	for,flushed
R6662	T10435	T10436	nummod	6,days
R6663	T10436	T10434	pobj	days,for
R6664	T10437	T10435	cc	or,6
R6665	T10438	T10435	conj	18,6
R6666	T10439	T10440	mark	as,described
R6667	T10440	T10400	advcl	described,flushed
R6668	T10441	T10442	punct	[,63
R6669	T10442	T10400	parataxis	63,flushed
R6670	T10443	T10442	punct	],63
R6671	T10444	T10400	punct	.,flushed
R6672	T10446	T10447	nsubjpass	Cultures,stained
R6673	T10448	T10447	auxpass	were,stained
R6674	T10449	T10450	advmod	in,situ
R6675	T10450	T10447	advmod	situ,stained
R6676	T10451	T10447	prep	for,stained
R6677	T10452	T10453	compound	ALP,activity
R6678	T10453	T10451	pobj	activity,for
R6679	T10454	T10451	cc	and,for
R6680	T10455	T10451	conj	with,for
R6681	T10456	T10457	compound	von,Kossa
R6682	T10457	T10458	compound	Kossa,stain
R6683	T10458	T10455	pobj	stain,with
R6684	T10459	T10460	aux	to,detect
R6685	T10460	T10447	advcl	detect,stained
R6686	T10461	T10462	amod	mineralized,nodules
R6687	T10462	T10460	dobj	nodules,detect
R6688	T10463	T10447	punct	.,stained
R6689	T10465	T10466	amod	Total,RNA
R6690	T10466	T10467	nsubjpass	RNA,harvested
R6691	T10468	T10467	auxpass	was,harvested
R6692	T10469	T10467	prep	from,harvested
R6693	T10470	T10471	amod	parallel,cultures
R6694	T10471	T10469	pobj	cultures,from
R6695	T10472	T10467	prep	for,harvested
R6696	T10473	T10474	compound	RT,PCR
R6697	T10474	T10476	compound	PCR,analysis
R6698	T10475	T10474	punct	-,PCR
R6699	T10476	T10472	pobj	analysis,for
R6700	T10477	T10476	prep	of,analysis
R6701	T10478	T10479	npadvmod	osteoblast,related
R6702	T10479	T10481	amod	related,expression
R6703	T10480	T10479	punct	-,related
R6704	T10481	T10477	pobj	expression,of
R6705	T10482	T10481	compound	gene,expression
R6706	T10483	T10467	prep	over,harvested
R6707	T10484	T10483	pobj	time,over
R6708	T10485	T10486	mark	as,described
R6709	T10486	T10467	advcl	described,harvested
R6710	T10487	T10486	advmod	previously,described
R6711	T10488	T10489	punct	[,63
R6712	T10489	T10467	parataxis	63,harvested
R6713	T10490	T10489	punct	],63
R6714	T10491	T10467	punct	.,harvested
R6715	T10493	T10494	nsubj	Osteoclasts,isolated
R6716	T10495	T10494	aux	were,isolated
R6717	T10496	T10494	prep	from,isolated
R6718	T10497	T10498	det	the,bones
R6719	T10498	T10496	pobj	bones,from
R6720	T10499	T10498	amod	crushed,bones
R6721	T10500	T10498	amod	long,bones
R6722	T10501	T10498	prep	of,bones
R6723	T10502	T10503	amod	juvenile,mice
R6724	T10503	T10501	pobj	mice,of
R6725	T10504	T10503	nmod	Sam68,mice
R6726	T10505	T10504	punct	+,Sam68
R6727	T10506	T10504	punct	/,Sam68
R6728	T10507	T10504	punct	+,Sam68
R6729	T10508	T10504	cc	and,Sam68
R6730	T10509	T10504	conj	Sam68,Sam68
R6731	T10510	T10509	punct	−,Sam68
R6732	T10511	T10509	punct	/,Sam68
R6733	T10512	T10509	punct	−,Sam68
R6734	T10513	T10494	cc	and,isolated
R6735	T10514	T10494	conj	used,isolated
R6736	T10515	T10514	prep	for,used
R6737	T10516	T10517	amod	quantitative,studies
R6738	T10517	T10515	pobj	studies,for
R6739	T10518	T10519	mark	as,described
R6740	T10519	T10494	advcl	described,isolated
R6741	T10520	T10521	punct	[,64
R6742	T10521	T10494	parataxis	64,isolated
R6743	T10522	T10521	punct	],64
R6744	T10523	T10494	punct	.,isolated
R6745	T10525	T10526	advmod	Briefly,plated
R6746	T10527	T10526	punct	", ",plated
R6747	T10528	T10526	nsubjpass	cells,plated
R6748	T10529	T10526	auxpass	were,plated
R6749	T10530	T10526	prep	on,plated
R6750	T10531	T10532	compound	glass,coverslips
R6751	T10532	T10530	pobj	coverslips,on
R6752	T10533	T10530	cc	or,on
R6753	T10534	T10530	conj	on,on
R6754	T10535	T10536	compound	dentin,slices
R6755	T10536	T10534	pobj	slices,on
R6756	T10537	T10526	prep	in,plated
R6757	T10538	T10539	nummod	24,well
R6758	T10539	T10541	compound	well,plates
R6759	T10540	T10539	punct	-,well
R6760	T10541	T10537	pobj	plates,in
R6761	T10542	T10541	compound	cluster,plates
R6762	T10543	T10526	prep	for,plated
R6763	T10544	T10543	pobj	assessment,for
R6764	T10545	T10544	prep	of,assessment
R6765	T10546	T10547	compound	cell,number
R6766	T10547	T10545	pobj	number,of
R6767	T10548	T10547	cc	and,number
R6768	T10549	T10550	compound	pit,number
R6769	T10550	T10547	conj	number,number
R6770	T10551	T10526	punct	", ",plated
R6771	T10552	T10526	advmod	respectively,plated
R6772	T10553	T10526	punct	.,plated
R6773	T10555	T10556	compound	Cover,slips
R6774	T10556	T10557	nsubjpass	slips,immersed
R6775	T10558	T10557	auxpass	were,immersed
R6776	T10559	T10557	prep	in,immersed
R6777	T10560	T10561	nummod	4,%
R6778	T10561	T10562	compound	%,paraformaldehyde
R6779	T10562	T10559	pobj	paraformaldehyde,in
R6780	T10563	T10557	cc	and,immersed
R6781	T10564	T10557	conj	stained,immersed
R6782	T10565	T10564	prep	for,stained
R6783	T10566	T10567	compound	TRAP,activity
R6784	T10567	T10565	pobj	activity,for
R6785	T10568	T10564	prep	after,stained
R6786	T10569	T10570	nummod	2,h
R6787	T10570	T10568	pobj	h,after
R6788	T10571	T10557	punct	.,immersed
R6789	T10573	T10574	compound	Dentin,slices
R6790	T10574	T10575	nsubjpass	slices,left
R6791	T10576	T10575	auxpass	were,left
R6792	T10577	T10575	prep	for,left
R6793	T10578	T10579	nummod	28,h
R6794	T10579	T10577	pobj	h,for
R6795	T10580	T10575	prep	before,left
R6796	T10581	T10580	pcomp	removing,before
R6797	T10582	T10583	det	the,cells
R6798	T10583	T10581	dobj	cells,removing
R6799	T10584	T10581	prep	with,removing
R6800	T10585	T10586	nummod	1,M
R6801	T10586	T10587	compound	M,hydroxide
R6802	T10587	T10584	pobj	hydroxide,with
R6803	T10588	T10587	compound	ammonium,hydroxide
R6804	T10589	T10581	cc	and,removing
R6805	T10590	T10591	dep	air,drying
R6806	T10591	T10581	conj	drying,removing
R6807	T10592	T10591	prep	before,drying
R6808	T10593	T10592	pobj	coating,before
R6809	T10594	T10593	prep	with,coating
R6810	T10595	T10596	compound	sputter,Pd
R6811	T10596	T10594	pobj	Pd,with
R6812	T10597	T10596	compound	Au,Pd
R6813	T10598	T10596	punct	-,Pd
R6814	T10599	T10593	cc	and,coating
R6815	T10600	T10593	conj	examination,coating
R6816	T10601	T10600	prep	with,examination
R6817	T10602	T10603	amod	scanning,microscopy
R6818	T10603	T10601	pobj	microscopy,with
R6819	T10604	T10603	compound	electron,microscopy
R6820	T10605	T10606	punct	(,Centre
R6821	T10606	T10603	parataxis	Centre,microscopy
R6822	T10607	T10606	compound	McGill,Centre
R6823	T10608	T10609	compound	Electron,Microscopy
R6824	T10609	T10606	compound	Microscopy,Centre
R6825	T10610	T10606	punct	),Centre
R6826	T10611	T10575	punct	.,left
R6827	T10613	T10614	compound	Light,microscope
R6828	T10614	T10615	compound	microscope,images
R6829	T10615	T10616	nsubjpass	images,captured
R6830	T10617	T10616	auxpass	were,captured
R6831	T10618	T10616	advcl	using,captured
R6832	T10619	T10620	det	a,microscope
R6833	T10620	T10618	dobj	microscope,using
R6834	T10621	T10622	compound	Leica,DMR
R6835	T10622	T10620	compound	DMR,microscope
R6836	T10623	T10620	acl	equipped,microscope
R6837	T10624	T10623	prep	with,equipped
R6838	T10625	T10626	det	a,camera
R6839	T10626	T10624	pobj	camera,with
R6840	T10627	T10626	nmod	Retiga,camera
R6841	T10628	T10627	nummod	1300,Retiga
R6842	T10629	T10616	punct	.,captured
R6843	T10631	T10632	amod	Quantitative,analyses
R6844	T10632	T10633	nsubjpass	analyses,performed
R6845	T10634	T10633	auxpass	were,performed
R6846	T10635	T10633	advcl	using,performed
R6847	T10636	T10637	compound	Adobe,Photoshop
R6848	T10637	T10635	dobj	Photoshop,using
R6849	T10638	T10637	cc	and,Photoshop
R6850	T10639	T10640	det	the,data
R6851	T10640	T10637	conj	data,Photoshop
R6852	T10641	T10640	acl	presented,data
R6853	T10642	T10641	prep	as,presented
R6854	T10643	T10644	det	the,SD
R6855	T10644	T10642	pobj	SD,as
R6856	T10645	T10644	nmod	mean,SD
R6857	T10646	T10644	punct	±,SD
R6858	T10647	T10644	prep	of,SD
R6859	T10648	T10649	nummod	two,experiments
R6860	T10649	T10647	pobj	experiments,of
R6861	T10650	T10648	cc	or,two
R6862	T10651	T10648	conj	three,two
R6863	T10652	T10649	amod	independent,experiments
R6864	T10653	T10633	punct	.,performed
R6865	T10655	T10656	amod	Statistical,comparisons
R6866	T10656	T10657	nsubjpass	comparisons,made
R6867	T10658	T10657	auxpass	were,made
R6868	T10659	T10657	advcl	using,made
R6869	T10660	T10661	det	the,Student
R6870	T10661	T10662	poss	Student,test
R6871	T10662	T10659	dobj	test,using
R6872	T10663	T10661	case	's,Student
R6873	T10664	T10662	compound	t,test
R6874	T10665	T10657	punct	.,made
R6875	T10694	T10693	prep	of,Preparation
R6876	T10695	T10696	nmod	mouse,fibroblast
R6877	T10696	T10694	pobj	fibroblast,of
R6878	T10697	T10696	amod	embryonic,fibroblast
R6879	T10698	T10693	cc	and,Preparation
R6880	T10699	T10693	conj	induction,Preparation
R6881	T10700	T10699	prep	of,induction
R6882	T10701	T10702	compound	adipocyte,differentiation
R6883	T10702	T10700	pobj	differentiation,of
R6884	T10703	T10699	punct	.,induction
R6885	T10705	T10706	nsubjpass	MEFs,prepared
R6886	T10707	T10706	auxpass	were,prepared
R6887	T10708	T10706	prep	from,prepared
R6888	T10709	T10710	nummod	14.5,day
R6889	T10710	T10712	npadvmod	day,old
R6890	T10711	T10710	punct	-,day
R6891	T10712	T10714	amod	old,embryos
R6892	T10713	T10712	punct	-,old
R6893	T10714	T10708	pobj	embryos,from
R6894	T10715	T10706	punct	.,prepared
R6895	T10717	T10718	advmod	Only,MEFs
R6896	T10718	T10722	nsubjpass	MEFs,used
R6897	T10719	T10720	amod	early,passage
R6898	T10720	T10718	compound	passage,MEFs
R6899	T10721	T10720	punct	-,passage
R6900	T10723	T10722	auxpass	were,used
R6901	T10724	T10722	prep	for,used
R6902	T10725	T10726	det	the,studies
R6903	T10726	T10724	pobj	studies,for
R6904	T10727	T10726	amod	experimental,studies
R6905	T10728	T10722	punct	", ",used
R6906	T10729	T10722	cc	and,used
R6907	T10730	T10731	nsubjpass	induction,carried
R6908	T10731	T10722	conj	carried,used
R6909	T10732	T10730	prep	of,induction
R6910	T10733	T10734	compound	adipocyte,differentiation
R6911	T10734	T10732	pobj	differentiation,of
R6912	T10735	T10731	auxpass	was,carried
R6913	T10736	T10731	prt	out,carried
R6914	T10737	T10731	prep	according,carried
R6915	T10738	T10737	prep	to,according
R6916	T10739	T10740	det	the,methods
R6917	T10740	T10738	pobj	methods,to
R6918	T10741	T10742	advmod	previously,described
R6919	T10742	T10740	acl	described,methods
R6920	T10743	T10744	punct	[,30
R6921	T10744	T10731	parataxis	30,carried
R6922	T10745	T10744	punct	],30
R6923	T10746	T10731	punct	.,carried
R6924	T10748	T10749	amod	Cultured,cells
R6925	T10749	T10750	nsubjpass	cells,stained
R6926	T10751	T10750	auxpass	were,stained
R6927	T10752	T10750	prep	with,stained
R6928	T10753	T10754	compound	Oil,O
R6929	T10754	T10752	pobj	O,with
R6930	T10755	T10754	compound	Red,O
R6931	T10756	T10757	mark	as,described
R6932	T10757	T10750	advcl	described,stained
R6933	T10758	T10759	punct	[,29
R6934	T10759	T10750	parataxis	29,stained
R6935	T10760	T10759	punct	],29
R6936	T10761	T10750	punct	.,stained
R6937	T10818	T10819	compound	RNA,preparation
R6938	T10820	T10819	cc	and,preparation
R6939	T10821	T10822	compound	RT,PCR
R6940	T10822	T10819	conj	PCR,preparation
R6941	T10823	T10822	punct	-,PCR
R6942	T10824	T10825	aux	to,assess
R6943	T10825	T10819	advcl	assess,preparation
R6944	T10826	T10825	dobj	adipogenesis,assess
R6945	T10827	T10825	prep	in,assess
R6946	T10828	T10829	nmod	Sam68,MEFs
R6947	T10829	T10827	pobj	MEFs,in
R6948	T10830	T10828	punct	−,Sam68
R6949	T10831	T10828	punct	/,Sam68
R6950	T10832	T10828	punct	−,Sam68
R6951	T10833	T10819	punct	.,preparation
R6952	T10835	T10836	amod	Total,RNA
R6953	T10836	T10838	nsubjpass	RNA,prepared
R6954	T10837	T10836	amod	cellular,RNA
R6955	T10839	T10838	auxpass	was,prepared
R6956	T10840	T10838	prep	by,prepared
R6957	T10841	T10842	compound	TRIzol,reagent
R6958	T10842	T10840	pobj	reagent,by
R6959	T10843	T10838	prep	according,prepared
R6960	T10844	T10843	prep	to,according
R6961	T10845	T10846	det	the,manufacturer
R6962	T10846	T10847	poss	manufacturer,protocol
R6963	T10847	T10844	pobj	protocol,to
R6964	T10848	T10846	case	's,manufacturer
R6965	T10849	T10850	punct	(,Invitrogen
R6966	T10850	T10847	parataxis	Invitrogen,protocol
R6967	T10851	T10850	punct	", ",Invitrogen
R6968	T10852	T10850	npadvmod	Carlsbad,Invitrogen
R6969	T10853	T10850	punct	", ",Invitrogen
R6970	T10854	T10850	npadvmod	California,Invitrogen
R6971	T10855	T10850	punct	", ",Invitrogen
R6972	T10856	T10857	compound	United,States
R6973	T10857	T10850	npadvmod	States,Invitrogen
R6974	T10858	T10850	punct	),Invitrogen
R6975	T10859	T10838	punct	.,prepared
R6976	T10861	T10862	amod	Total,RNA
R6977	T10862	T10863	nsubjpass	RNA,transcribed
R6978	T10864	T10865	punct	(,μg
R6979	T10865	T10862	parataxis	μg,RNA
R6980	T10866	T10865	nummod	1,μg
R6981	T10867	T10865	punct	),μg
R6982	T10868	T10863	auxpass	was,transcribed
R6983	T10869	T10863	advmod	reverse,transcribed
R6984	T10870	T10863	punct	-,transcribed
R6985	T10871	T10863	punct	", ",transcribed
R6986	T10872	T10863	cc	and,transcribed
R6987	T10873	T10874	compound	cDNA,samples
R6988	T10874	T10875	nsubjpass	samples,subjected
R6989	T10875	T10863	conj	subjected,transcribed
R6990	T10876	T10875	auxpass	were,subjected
R6991	T10877	T10875	prep	to,subjected
R6992	T10878	T10877	pobj	PCR,to
R6993	T10879	T10875	punct	.,subjected
R6994	T10881	T10882	compound	RT,PCR
R6995	T10882	T10884	nsubjpass	PCR,normalized
R6996	T10883	T10882	punct	-,PCR
R6997	T10885	T10884	auxpass	was,normalized
R6998	T10886	T10884	agent	by,normalized
R6999	T10887	T10888	det	the,level
R7000	T10888	T10886	pobj	level,by
R7001	T10889	T10888	amod	transcriptional,level
R7002	T10890	T10888	prep	of,level
R7003	T10891	T10890	pobj	GAPDH,of
R7004	T10892	T10884	punct	.,normalized
R7005	T10894	T10895	det	The,primers
R7006	T10895	T10902	nsubjpass	primers,used
R7007	T10896	T10895	amod	following,primers
R7008	T10897	T10895	nummod	5,primers
R7009	T10898	T10897	punct	′,5
R7010	T10899	T10897	cc	and,5
R7011	T10900	T10897	conj	3,5
R7012	T10901	T10900	punct	′,3
R7013	T10903	T10902	auxpass	were,used
R7014	T10904	T10905	aux	to,evaluate
R7015	T10905	T10902	advcl	evaluate,used
R7016	T10906	T10907	amod	adipogenic,differentiation
R7017	T10907	T10905	dobj	differentiation,evaluate
R7018	T10908	T10902	punct	: ,used
R7019	T10909	T10902	dep	KLF5,used
R7020	T10910	T10909	punct	: ,KLF5
R7021	T10911	T10909	appos	5,KLF5
R7022	T10912	T10911	punct	',5
R7023	T10913	T10911	punct	-,5
R7024	T10914	T10915	compound	AGA,C
R7025	T10915	T10911	appos	C,5
R7026	T10916	T10915	compound	CAA,C
R7027	T10917	T10915	compound	GCT,C
R7028	T10918	T10915	compound	GAG,C
R7029	T10919	T10915	compound	ATG,C
R7030	T10920	T10915	compound	CTG,C
R7031	T10921	T10911	punct	-,5
R7032	T10922	T10911	nummod	3,5
R7033	T10923	T10911	punct	′,5
R7034	T10924	T10911	punct	", ",5
R7035	T10925	T10911	appos	5,5
R7036	T10926	T10925	punct	′,5
R7037	T10927	T10925	punct	-,5
R7038	T10928	T10929	compound	GGC,GC
R7039	T10929	T10925	appos	GC,5
R7040	T10930	T10929	compound	AAA,GC
R7041	T10931	T10929	compound	CCT,GC
R7042	T10932	T10929	compound	CCA,GC
R7043	T10933	T10929	compound	GTC,GC
R7044	T10934	T10925	punct	-,5
R7045	T10935	T10925	nummod	3,5
R7046	T10936	T10925	punct	′,5
R7047	T10937	T10909	punct	;,KLF5
R7048	T10938	T10909	conj	PPARγ,KLF5
R7049	T10939	T10938	punct	: ,PPARγ
R7050	T10940	T10938	appos	5,PPARγ
R7051	T10941	T10940	punct	′,5
R7052	T10942	T10940	punct	-,5
R7053	T10943	T10944	compound	GTG,C
R7054	T10944	T10940	appos	C,5
R7055	T10945	T10944	compound	CGA,C
R7056	T10946	T10944	compound	TCA,C
R7057	T10947	T10944	compound	AAG,C
R7058	T10948	T10944	compound	TAG,C
R7059	T10949	T10944	compound	AAC,C
R7060	T10950	T10944	compound	CTG,C
R7061	T10951	T10940	punct	-,5
R7062	T10952	T10940	nummod	3,5
R7063	T10953	T10940	punct	′,5
R7064	T10954	T10940	punct	", ",5
R7065	T10955	T10940	appos	5,5
R7066	T10956	T10955	punct	′,5
R7067	T10957	T10955	punct	-,5
R7068	T10958	T10959	compound	CCT,TCG
R7069	T10959	T10955	appos	TCG,5
R7070	T10960	T10959	compound	ATC,TCG
R7071	T10961	T10959	compound	ATA,TCG
R7072	T10962	T10959	compound	AAT,TCG
R7073	T10963	T10959	compound	AAG,TCG
R7074	T10964	T10959	compound	CTT,TCG
R7075	T10965	T10959	compound	CAA,TCG
R7076	T10966	T10955	punct	-,5
R7077	T10967	T10955	nummod	3,5
R7078	T10968	T10955	punct	′,5
R7079	T10969	T10938	punct	;,PPARγ
R7080	T10970	T10971	compound	β,Actin
R7081	T10971	T10938	conj	Actin,PPARγ
R7082	T10972	T10971	punct	-,Actin
R7083	T10973	T10971	punct	: ,Actin
R7084	T10974	T10971	appos	5,Actin
R7085	T10975	T10974	punct	′,5
R7086	T10976	T10974	punct	-,5
R7087	T10977	T10978	compound	TAG,GC
R7088	T10978	T10974	appos	GC,5
R7089	T10979	T10978	compound	GCG,GC
R7090	T10980	T10978	compound	GAC,GC
R7091	T10981	T10978	compound	TGT,GC
R7092	T10982	T10978	compound	TAC,GC
R7093	T10983	T10978	compound	TGA,GC
R7094	T10984	T10974	punct	-,5
R7095	T10985	T10974	nummod	3,5
R7096	T10986	T10974	punct	′,5
R7097	T10987	T10974	punct	", ",5
R7098	T10988	T10974	appos	5,5
R7099	T10989	T10988	punct	′,5
R7100	T10990	T10988	punct	-,5
R7101	T10991	T10992	compound	AGC,TGG
R7102	T10992	T10988	appos	TGG,5
R7103	T10993	T10992	compound	CTT,TGG
R7104	T10994	T10992	compound	CAT,TGG
R7105	T10995	T10992	compound	ACA,TGG
R7106	T10996	T10992	compound	TCA,TGG
R7107	T10997	T10992	compound	AGT,TGG
R7108	T10998	T10988	punct	-,5
R7109	T10999	T10988	nummod	3,5
R7110	T11000	T10988	punct	′,5
R7111	T11001	T10971	punct	;,Actin
R7112	T11002	T10971	cc	and,Actin
R7113	T11003	T10971	conj	Sam68,Actin
R7114	T11004	T11003	punct	: ,Sam68
R7115	T11005	T11003	appos	5,Sam68
R7116	T11006	T11005	punct	′,5
R7117	T11007	T11005	punct	-,5
R7118	T11008	T11009	compound	GTG,A
R7119	T11009	T11005	appos	A,5
R7120	T11010	T11009	compound	GAG,A
R7121	T11011	T11009	compound	ACC,A
R7122	T11012	T11009	compound	CCA,A
R7123	T11013	T11009	compound	AAT,A
R7124	T11014	T11009	compound	ATG,A
R7125	T11015	T11009	compound	CCC,A
R7126	T11016	T11005	punct	-,5
R7127	T11017	T11005	nummod	3,5
R7128	T11018	T11005	punct	′,5
R7129	T11019	T11005	cc	and,5
R7130	T11020	T11005	conj	5,5
R7131	T11021	T11020	punct	′,5
R7132	T11022	T11020	punct	-,5
R7133	T11023	T11024	compound	AAA,A
R7134	T11024	T11020	appos	A,5
R7135	T11025	T11024	compound	CTG,A
R7136	T11026	T11024	compound	CTC,A
R7137	T11027	T11024	compound	CTG,A
R7138	T11028	T11024	compound	ACA,A
R7139	T11029	T11024	compound	GAT,A
R7140	T11030	T11024	compound	ATC,A
R7141	T11031	T11020	punct	-,5
R7142	T11032	T11020	nummod	3,5
R7143	T11033	T11020	punct	′,5
R7144	T11034	T10902	punct	.,used
R7145	T11076	T11077	nmod	Sam68,regulation
R7146	T11078	T11077	advmod	down,regulation
R7147	T11079	T11077	punct	-,regulation
R7148	T11080	T11077	acl	using,regulation
R7149	T11081	T11080	dobj	Sam68sh,using
R7150	T11082	T11077	punct	.,regulation
R7151	T11084	T11085	aux	To,generate
R7152	T11085	T11086	advcl	generate,purchased
R7153	T11087	T11088	det	an,shRNA
R7154	T11088	T11085	dobj	shRNA,generate
R7155	T11089	T11086	punct	", ",purchased
R7156	T11090	T11091	nummod	64,base
R7157	T11091	T11093	compound	base,nucleotides
R7158	T11092	T11091	punct	-,base
R7159	T11093	T11086	nsubjpass	nucleotides,purchased
R7160	T11094	T11093	compound	duplex,nucleotides
R7161	T11095	T11093	compound	DNA,nucleotides
R7162	T11096	T11086	auxpass	were,purchased
R7163	T11097	T11086	prep	from,purchased
R7164	T11098	T11097	pobj	Invitrogen,from
R7165	T11099	T11086	punct	.,purchased
R7166	T11101	T11102	det	This,fragment
R7167	T11102	T11103	nsubj	fragment,comprised
R7168	T11104	T11105	nummod	19,residues
R7169	T11105	T11103	dobj	residues,comprised
R7170	T11106	T11105	compound	base,residues
R7171	T11107	T11105	amod	specific,residues
R7172	T11108	T11107	prep	to,specific
R7173	T11109	T11110	compound	mouse,Sam68
R7174	T11110	T11108	pobj	Sam68,to
R7175	T11111	T11112	punct	(,TTTTTGGAAA
R7176	T11112	T11103	parataxis	TTTTTGGAAA,comprised
R7177	T11113	T11112	compound	GATCCCC,TTTTTGGAAA
R7178	T11114	T11112	compound	AAGATGACGAGGAGAATTATTCAAGAGA,TTTTTGGAAA
R7179	T11115	T11112	compound	TAATTCTCCTCGTCATCTT,TTTTTGGAAA
R7180	T11116	T11112	punct	),TTTTTGGAAA
R7181	T11117	T11103	punct	.,comprised
R7182	T11119	T11120	det	This,fragment
R7183	T11120	T11121	nsubjpass	fragment,cloned
R7184	T11122	T11121	auxpass	was,cloned
R7185	T11123	T11121	prep	into,cloned
R7186	T11124	T11125	compound	pSUPER,retro
R7187	T11125	T11123	pobj	retro,into
R7188	T11126	T11127	punct	(,OligoEngine
R7189	T11127	T11125	parataxis	OligoEngine,retro
R7190	T11128	T11127	punct	", ",OligoEngine
R7191	T11129	T11127	npadvmod	Seattle,OligoEngine
R7192	T11130	T11127	punct	", ",OligoEngine
R7193	T11131	T11127	npadvmod	Washington,OligoEngine
R7194	T11132	T11127	punct	", ",OligoEngine
R7195	T11133	T11134	compound	United,States
R7196	T11134	T11127	npadvmod	States,OligoEngine
R7197	T11135	T11127	punct	),OligoEngine
R7198	T11136	T11121	punct	.,cloned
R7199	T11138	T11139	nsubjpass	Transfections,performed
R7200	T11140	T11139	auxpass	were,performed
R7201	T11141	T11139	advcl	using,performed
R7202	T11142	T11143	compound	LipofectAMINE,Plus
R7203	T11143	T11141	dobj	Plus,using
R7204	T11144	T11145	punct	(,Invitrogen
R7205	T11145	T11143	parataxis	Invitrogen,Plus
R7206	T11146	T11145	punct	),Invitrogen
R7207	T11147	T11141	prep	with,using
R7208	T11148	T11149	amod	cloned,fragment
R7209	T11149	T11147	pobj	fragment,with
R7210	T11150	T11149	compound	DNA,fragment
R7211	T11151	T11149	cc	or,fragment
R7212	T11152	T11153	amod	empty,vector
R7213	T11153	T11149	conj	vector,fragment
R7214	T11154	T11139	punct	.,performed
R7215	T11156	T11157	prep	At,selected
R7216	T11158	T11159	nummod	48,h
R7217	T11159	T11156	pobj	h,At
R7218	T11160	T11159	prep	after,h
R7219	T11161	T11160	pobj	transfection,after
R7220	T11162	T11157	punct	", ",selected
R7221	T11163	T11157	nsubjpass	populations,selected
R7222	T11164	T11157	auxpass	were,selected
R7223	T11165	T11157	prep	for,selected
R7224	T11166	T11167	nummod	2.5,μg
R7225	T11167	T11168	nmod	μg,puromycin
R7226	T11168	T11165	pobj	puromycin,for
R7227	T11169	T11170	punct	/,ml
R7228	T11170	T11167	prep	ml,μg
R7229	T11171	T11157	cc	and,selected
R7230	T11172	T11173	det	the,knockdown
R7231	T11173	T11174	nsubj	knockdown,observed
R7232	T11174	T11157	conj	observed,selected
R7233	T11175	T11174	prep	by,observed
R7234	T11176	T11175	pcomp	immunoblotting,by
R7235	T11177	T11176	prep	with,immunoblotting
R7236	T11178	T11179	nmod	anti-Sam68,antibody
R7237	T11179	T11177	pobj	antibody,with
R7238	T11180	T11181	punct	(,AD1
R7239	T11181	T11178	parataxis	AD1,anti-Sam68
R7240	T11182	T11181	punct	),AD1
R7241	T11183	T11157	punct	.,selected
R7242	T11232	T11233	amod	Osteogenic,analysis
R7243	T11234	T11233	compound	differentiation,analysis
R7244	T11235	T11233	prep	of,analysis
R7245	T11236	T11237	nmod	C3HT101,cells
R7246	T11237	T11235	pobj	cells,of
R7247	T11238	T11236	punct	/,C3HT101
R7248	T11239	T11236	nummod	2,C3HT101
R7249	T11240	T11233	punct	.,analysis
R7250	T11242	T11243	prep	For,incubated
R7251	T11244	T11245	amod	osteogenic,differentiation
R7252	T11245	T11242	pobj	differentiation,For
R7253	T11246	T11243	punct	", ",incubated
R7254	T11247	T11248	nmod	C3HT101,cells
R7255	T11248	T11243	nsubjpass	cells,incubated
R7256	T11249	T11247	punct	/,C3HT101
R7257	T11250	T11247	nummod	2,C3HT101
R7258	T11251	T11252	punct	(,ATCC
R7259	T11252	T11247	parataxis	ATCC,C3HT101
R7260	T11253	T11252	punct	),ATCC
R7261	T11254	T11243	auxpass	were,incubated
R7262	T11255	T11243	prep	in,incubated
R7263	T11256	T11257	nummod	48,well
R7264	T11257	T11259	compound	well,plates
R7265	T11258	T11257	punct	-,well
R7266	T11259	T11255	pobj	plates,in
R7267	T11260	T11259	compound	tissue,plates
R7268	T11261	T11259	compound	culture,plates
R7269	T11262	T11243	prep	at,incubated
R7270	T11263	T11264	quantmod	1.25,104
R7271	T11264	T11266	nummod	104,cells
R7272	T11265	T11264	punct	×,104
R7273	T11266	T11262	pobj	cells,at
R7274	T11267	T11268	punct	/,cm2
R7275	T11268	T11266	prep	cm2,cells
R7276	T11269	T11243	punct	.,incubated
R7277	T11271	T11272	prep	After,changed
R7278	T11273	T11274	nummod	24,h
R7279	T11274	T11276	compound	h,incubation
R7280	T11275	T11274	punct	-,h
R7281	T11276	T11271	pobj	incubation,After
R7282	T11277	T11272	punct	", ",changed
R7283	T11278	T11279	det	the,media
R7284	T11279	T11272	nsubjpass	media,changed
R7285	T11280	T11279	compound	culture,media
R7286	T11281	T11272	auxpass	were,changed
R7287	T11282	T11272	prep	to,changed
R7288	T11283	T11284	amod	fresh,media
R7289	T11284	T11282	pobj	media,to
R7290	T11285	T11284	acl	containing,media
R7291	T11286	T11287	nummod	300,ng
R7292	T11287	T11288	nmod	ng,BMP
R7293	T11288	T11285	dobj	BMP,containing
R7294	T11289	T11290	punct	/,ml
R7295	T11290	T11287	prep	ml,ng
R7296	T11291	T11288	punct	-,BMP
R7297	T11292	T11288	nummod	2,BMP
R7298	T11293	T11294	punct	(,Sigma
R7299	T11294	T11288	parataxis	Sigma,BMP
R7300	T11295	T11294	punct	", ",Sigma
R7301	T11296	T11297	compound	St.,Louis
R7302	T11297	T11294	npadvmod	Louis,Sigma
R7303	T11298	T11294	punct	", ",Sigma
R7304	T11299	T11294	npadvmod	Missouri,Sigma
R7305	T11300	T11294	punct	", ",Sigma
R7306	T11301	T11302	compound	United,States
R7307	T11302	T11294	npadvmod	States,Sigma
R7308	T11303	T11294	punct	),Sigma
R7309	T11304	T11272	punct	.,changed
R7310	T11306	T11307	amod	Total,RNA
R7311	T11307	T11309	nsubjpass	RNA,prepared
R7312	T11308	T11307	amod	cellular,RNA
R7313	T11310	T11309	auxpass	was,prepared
R7314	T11311	T11312	mark	as,described
R7315	T11312	T11309	advcl	described,prepared
R7316	T11313	T11312	advmod	above,described
R7317	T11314	T11309	punct	", ",prepared
R7318	T11315	T11309	cc	and,prepared
R7319	T11316	T11317	nmod	osteocalcin,expression
R7320	T11317	T11326	nsubjpass	expression,quantified
R7321	T11318	T11316	punct	", ",osteocalcin
R7322	T11319	T11320	compound	β,actin
R7323	T11320	T11316	conj	actin,osteocalcin
R7324	T11321	T11320	punct	-,actin
R7325	T11322	T11320	punct	", ",actin
R7326	T11323	T11320	cc	and,actin
R7327	T11324	T11320	conj	GAPDH,actin
R7328	T11325	T11317	compound	gene,expression
R7329	T11326	T11309	conj	quantified,prepared
R7330	T11327	T11317	prep	at,expression
R7331	T11328	T11329	amod	indicated,times
R7332	T11329	T11327	pobj	times,at
R7333	T11330	T11329	prep	after,times
R7334	T11331	T11332	nmod	BMP,treatment
R7335	T11332	T11330	pobj	treatment,after
R7336	T11333	T11331	punct	-,BMP
R7337	T11334	T11331	nummod	2,BMP
R7338	T11335	T11326	auxpass	was,quantified
R7339	T11336	T11326	prep	by,quantified
R7340	T11337	T11338	compound	RT,PCR
R7341	T11338	T11336	pobj	PCR,by
R7342	T11339	T11338	punct	-,PCR
R7343	T11340	T11326	punct	.,quantified
R5342	T8712	T8708	nsubj	data,define
R5343	T8713	T8714	det	a,role
R5344	T8714	T8708	dobj	role,define

2_test

Id	Subject	Object	Predicate	Lexical cue
16362077-12748654-85614425	80-81	12748654	denotes	1
16362077-10968780-85614426	138-139	10968780	denotes	2
16362077-10780863-85614427	456-457	10780863	denotes	3
16362077-12810194-85614428	587-588	12810194	denotes	4
16362077-15201610-85614428	587-588	15201610	denotes	4
16362077-12050121-85614429	713-714	12050121	denotes	7
16362077-10660043-85614429	713-714	10660043	denotes	7
16362077-14978271-85614429	713-714	14978271	denotes	7
16362077-9658179-85614430	754-756	9658179	denotes	10
16362077-11970890-85614431	871-873	11970890	denotes	12
16362077-12748651-85614431	871-873	12748651	denotes	12
16362077-12080084-85614431	871-873	12080084	denotes	12
16362077-9495524-85614432	1104-1106	9495524	denotes	15
16362077-12081842-85614433	1246-1248	12081842	denotes	16
16362077-11120762-85614434	1282-1284	11120762	denotes	17
16362077-10660043-85614435	1340-1341	10660043	denotes	8
16362077-12419242-85614436	1342-1344	12419242	denotes	18
16362077-15724149-85614436	1342-1344	15724149	denotes	18
16362077-16143109-85614436	1342-1344	16143109	denotes	18
16362077-10782361-85614437	1393-1395	10782361	denotes	21
16362077-15140422-85614438	1625-1627	15140422	denotes	22
16362077-5133320-85614439	1757-1759	5133320	denotes	23
16362077-10102814-85614440	1977-1979	10102814	denotes	24
16362077-11792318-85614441	2189-2191	11792318	denotes	25
16362077-9182762-85614441	2189-2191	9182762	denotes	25
16362077-12000792-85614441	2189-2191	12000792	denotes	25
16362077-16054042-85614441	2189-2191	16054042	denotes	25
16362077-10549292-85614441	2189-2191	10549292	denotes	25
16362077-10549291-85614441	2189-2191	10549291	denotes	25
16362077-14732616-85614442	2477-2479	14732616	denotes	31
16362077-12633995-85614443	2534-2536	12633995	denotes	32
16362077-12467586-85614444	2669-2671	12467586	denotes	33
16362077-15568022-85614445	2868-2870	15568022	denotes	34
16362077-12050669-85614446	2964-2966	12050669	denotes	35
16362077-9118803-85614447	3102-3104	9118803	denotes	36
16362077-9169854-85614448	3105-3107	9169854	denotes	37
16362077-14643926-85614449	3234-3236	14643926	denotes	38
16362077-1374686-85614450	3428-3430	1374686	denotes	39
16362077-7799925-85614450	3428-3430	7799925	denotes	39
16362077-7512695-85614450	3428-3430	7512695	denotes	39
16362077-7512694-85614450	3428-3430	7512694	denotes	39
16362077-16179349-85614451	3467-3469	16179349	denotes	43
16362077-10371501-85614452	3540-3542	10371501	denotes	44
16362077-12478298-85614453	3581-3583	12478298	denotes	45
16362077-14643926-85614454	4572-4574	14643926	denotes	38
16362077-10077576-85614455	7920-7922	10077576	denotes	47
16362077-7512695-85614456	8409-8411	7512695	denotes	41
16362077-7512694-85614457	8412-8414	7512694	denotes	42
16362077-1997203-85614458	9995-9997	1997203	denotes	48
16362077-7816067-85614459	16578-16580	7816067	denotes	49
16362077-3455637-85614460	17242-17244	3455637	denotes	50
16362077-7816067-85614461	19293-19295	7816067	denotes	49
16362077-1997203-85614462	20575-20577	1997203	denotes	48
16362077-15140422-85614463	21947-21949	15140422	denotes	22
16362077-10660043-85614464	22326-22327	10660043	denotes	8
16362077-7798324-85614465	24540-24542	7798324	denotes	51
16362077-14643926-85614466	29250-29252	14643926	denotes	38
16362077-14996936-85614467	29501-29503	14996936	denotes	52
16362077-16179349-85614468	29567-29569	16179349	denotes	43
16362077-10077576-85614469	30230-30232	10077576	denotes	47
16362077-8706134-85614470	30754-30756	8706134	denotes	53
16362077-14824537-85614471	31242-31244	14824537	denotes	54
16362077-1997203-85614472	31805-31807	1997203	denotes	48
16362077-11038178-85614473	33859-33861	11038178	denotes	60
16362077-11062345-85614474	33862-33864	11062345	denotes	61
16362077-10660043-85614475	34248-34249	10660043	denotes	8
16362077-12419242-85614476	34250-34252	12419242	denotes	18
16362077-15724149-85614476	34250-34252	15724149	denotes	18
16362077-16143109-85614476	34250-34252	16143109	denotes	18
16362077-14681299-85614477	35558-35560	14681299	denotes	63
16362077-3455637-85614478	37035-37037	3455637	denotes	50
16362077-14681299-85614479	39844-39846	14681299	denotes	63
16362077-14681299-85614480	41495-41497	14681299	denotes	63
16362077-14681299-85614481	41743-41745	14681299	denotes	63
16362077-15695591-85614482	41889-41891	15695591	denotes	64
16362077-10549291-85614483	42968-42970	10549291	denotes	30
16362077-10549292-85614484	43030-43032	10549292	denotes	29
T99832	80-81	12748654	denotes	1
T80042	138-139	10968780	denotes	2
T94403	456-457	10780863	denotes	3
T30512	587-588	12810194	denotes	4
T78883	587-588	15201610	denotes	4
T68833	713-714	12050121	denotes	7
T53053	713-714	10660043	denotes	7
T68630	713-714	14978271	denotes	7
T71943	754-756	9658179	denotes	10
T15782	871-873	11970890	denotes	12
T92742	871-873	12748651	denotes	12
T34906	871-873	12080084	denotes	12
T98429	1104-1106	9495524	denotes	15
T60111	1246-1248	12081842	denotes	16
T46735	1282-1284	11120762	denotes	17
T35902	1340-1341	10660043	denotes	8
T72210	1342-1344	12419242	denotes	18
T76591	1342-1344	15724149	denotes	18
T99315	1342-1344	16143109	denotes	18
T54733	1393-1395	10782361	denotes	21
T48731	1625-1627	15140422	denotes	22
T96026	1757-1759	5133320	denotes	23
T7800	1977-1979	10102814	denotes	24
T14670	2189-2191	11792318	denotes	25
T63095	2189-2191	9182762	denotes	25
T95663	2189-2191	12000792	denotes	25
T94849	2189-2191	16054042	denotes	25
T36942	2189-2191	10549292	denotes	25
T86186	2189-2191	10549291	denotes	25
T87785	2477-2479	14732616	denotes	31
T88771	2534-2536	12633995	denotes	32
T54598	2669-2671	12467586	denotes	33
T66135	2868-2870	15568022	denotes	34
T5069	2964-2966	12050669	denotes	35
T47213	3102-3104	9118803	denotes	36
T29905	3105-3107	9169854	denotes	37
T61362	3234-3236	14643926	denotes	38
T53661	3428-3430	1374686	denotes	39
T12317	3428-3430	7799925	denotes	39
T8903	3428-3430	7512695	denotes	39
T87791	3428-3430	7512694	denotes	39
T44082	3467-3469	16179349	denotes	43
T97480	3540-3542	10371501	denotes	44
T83608	3581-3583	12478298	denotes	45
T73529	4572-4574	14643926	denotes	38
T41095	7920-7922	10077576	denotes	47
T41090	8409-8411	7512695	denotes	41
T67738	8412-8414	7512694	denotes	42
T52285	9995-9997	1997203	denotes	48
T57055	16578-16580	7816067	denotes	49
T36388	17242-17244	3455637	denotes	50
T98494	19293-19295	7816067	denotes	49
T17644	20575-20577	1997203	denotes	48
T11436	21947-21949	15140422	denotes	22
T63396	22326-22327	10660043	denotes	8
T35311	24540-24542	7798324	denotes	51
T43821	29250-29252	14643926	denotes	38
T22394	29501-29503	14996936	denotes	52
T12234	29567-29569	16179349	denotes	43
T40993	30230-30232	10077576	denotes	47
T15711	30754-30756	8706134	denotes	53
T11163	31242-31244	14824537	denotes	54
T16287	31805-31807	1997203	denotes	48
T82069	33859-33861	11038178	denotes	60
T40457	33862-33864	11062345	denotes	61
T47250	34248-34249	10660043	denotes	8
T62595	34250-34252	12419242	denotes	18
T28381	34250-34252	15724149	denotes	18
T91353	34250-34252	16143109	denotes	18
T53378	35558-35560	14681299	denotes	63
T86178	37035-37037	3455637	denotes	50
T43899	39844-39846	14681299	denotes	63
T13286	41495-41497	14681299	denotes	63
T88019	41743-41745	14681299	denotes	63
T33836	41889-41891	15695591	denotes	64
T84279	42968-42970	10549291	denotes	30
T89472	43030-43032	10549292	denotes	29

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T732	20-28	UBERON:0004288	denotes	skeletal
T733	20-40	GO:0001501	denotes	skeletal development
T734	67-78	CL:0000062	denotes	osteoblasts
T735	125-136	CL:0000092	denotes	osteoclasts
T736	187-195	UBERON:0004288	denotes	skeletal
T737	263-274	CL:0000062	denotes	osteoblasts
T738	279-290	CL:0000092	denotes	osteoclasts
T739	327-335	UBERON:0004288	denotes	skeletal
T740	336-341	GO:0007568	denotes	aging
T741	387-397	CL:0000092	denotes	osteoclast
T742	403-413	CL:0000062	denotes	osteoblast
T743	539-544	GO:0007568	denotes	aging
T744	665-676	_FRAGMENT	denotes	response of
T745	682-687	GO:0051716	denotes	cells
T746	677-687	CL:0001035	denotes	bone cells
T747	770-777	SO:0000704	denotes	genetic
T748	844-852	GO:0065007	denotes	regulate
T749	961-976	GO:0045453	denotes	bone resorption
T750	1210-1221	UBERON:0001132	denotes	parathyroid
T751	1230-1239	CHEBI:27300	denotes	vitamin D
T752	1254-1261	UBERON:0000991	denotes	gonadal
T753	1312-1338	UBERON:0000013	denotes	sympathetic nervous system
T754	1372-1381	CL:0001035	denotes	bone cell
T755	1377-1391	GO:0006915	denotes	cell apoptosis
T756	1470-1481	_FRAGMENT	denotes	response of
T757	1502-1507	GO:0051716	denotes	cells
T758	1482-1501	UBERON:0007195	denotes	bone marrow stromal
T759	1482-1507	CL:0010001	denotes	bone marrow stromal cells
T760	1571-1580	CL:0000136	denotes	adipocyte
T761	1605-1615	CL:0000062	denotes	osteoblast
T762	1630-1635	GO:0007568	denotes	Aging
T763	1681-1687	UBERON:0002371	denotes	marrow
T764	1717-1727	CL:0000136	denotes	adipocytes
T765	1744-1755	CL:0000062	denotes	osteoblasts
T766	1762-1773	CL:0000062	denotes	Osteoblasts
T767	1778-1788	CL:0000136	denotes	adipocytes
T768	1815-1826	UBERON:0003104	denotes	mesenchymal
T769	1853-1864	UBERON:0002371	denotes	bone marrow
T770	1887-1894	GO:0065007	denotes	control
T771	1926-1936	GO:0060612	denotes	adipogenic
T772	2012-2022	GO:0065007	denotes	regulatory
T773	2058-2081	GO:0001709	denotes	cell fate determination
T774	2085-2096	UBERON:0002371	denotes	bone marrow
T775	2085-2114	CL:0002540	denotes	bone marrow mesenchymal cells
T776	2097-2108	UBERON:0003104	denotes	mesenchymal
T777	2126-2136	GO:0005777	denotes	peroxisome
T778	2126-2170	PR:000013058	denotes	peroxisome proliferator–activated receptor γ
T779	2172-2177	PR:000013058	denotes	PPARγ
T780	2183-2187	PR:000009365	denotes	KLF5
T781	2323-2347	GO:0030154	denotes	cellular differentiation
T782	2362-2372	GO:0010467	denotes	expression
T783	2391-2397	SO:0000417	denotes	domain
T784	2416-2420	PR:000003389	denotes	FMRP
T785	2455-2465	UBERON:0001016	denotes	neurologic
T786	2497-2498	GO:0000805	denotes	X
T787	2526-2532	NCBITaxon:9606	denotes	humans
T788	2575-2579	NCBITaxon:10088	denotes	mice
T789	2604-2611	PR:000013564	denotes	QUAKING
T790	2635-2651	CL:0000128	denotes	oligodendrocytes
T791	2694-2704	GO:0010467	denotes	expression
T792	2712-2715	PR:000013564	denotes	QKI
T793	2720-2728	SO:0001060	denotes	isoforms
T794	2761-2772	CL:0000125	denotes	glial cells
T795	2785-2792	CL:0000540	denotes	neurons
T796	2843-2866	GO:0001709	denotes	cell fate determination
T797	2885-2890	PR:Q17339	denotes	GLD-1
T798	2902-2924	NCBITaxon:6239	denotes	Caenorhabditis elegans
T799	2952-2962	CL:0000034	denotes	stem cells
T800	2995-3001	SO:0000417	denotes	domain
T801	3010-3013	PR:O01367	denotes	HOW
T802	3017-3027	NCBITaxon:7215	denotes	Drosophila
T803	3075-3080	NCBITaxon:7147	denotes	flies
T804	3095-3100	UBERON:0000023	denotes	wings
T805	3114-3159	PR:000009279	denotes	Src substrate associated in mitosis of 68 kDa
T806	3142-3149	GO:0007067	denotes	mitosis
T807	3161-3166	PR:000009279	denotes	Sam68
T808	3205-3211	SO:0000417	denotes	domain
T809	3293-3298	PR:000009279	denotes	Sam68
T810	3332-3338	SO:0000417	denotes	domain
T811	3363-3381	PR:000002997	denotes	Src family kinases
T812	3415-3426	PR:000002997	denotes	Src kinases
T813	3446-3452	UBERON:0000310	denotes	breast
T814	3446-3465	PR:000013434	denotes	breast tumor kinase
T815	3472-3477	PR:000009279	denotes	Sam68
T816	3523-3530	GO:0008380	denotes	spliced
T817	3551-3559	GO:0065007	denotes	regulate
T818	3560-3568	SO:0000932	denotes	pre-mRNA
T819	3636-3641	PR:000009279	denotes	Sam68
T820	3645-3649	NCBITaxon:10088	denotes	mice
T821	3672-3680	UBERON:0004288	denotes	skeletal
T822	3730-3735	PR:000009279	denotes	Sam68
T823	3783-3787	NCBITaxon:10088	denotes	mice
T824	3802-3807	PR:000009279	denotes	Sam68
T825	3891-3896	PR:000009279	denotes	Sam68
T826	3897-3906	GO:0065007	denotes	regulates
T827	3911-3929	_FRAGMENT	denotes	differentiation of
T828	3950-3955	GO:0030154	denotes	cells
T829	3930-3949	UBERON:0007195	denotes	bone marrow stromal
T830	3930-3955	CL:0010001	denotes	bone marrow stromal cells
T831	3992-3997	PR:000009279	denotes	Sam68
T832	4001-4008	NCBITaxon:33208	denotes	animals
T833	4022-4032	GO:0001503	denotes	osteogenic
T834	4056-4066	GO:0060612	denotes	adipogenic
T835	4138-4143	PR:000009279	denotes	Sam68
T836	4147-4152	NCBITaxon:10088	denotes	mouse
T837	4153-4159	UBERON:0000922	denotes	embryo
T838	4160-4171	CL:0000057	denotes	fibroblasts
T839	4233-4243	CL:0000136	denotes	adipocytes
T840	4261-4266	PR:000009279	denotes	Sam68
T841	4288-4299	UBERON:0002371	denotes	bone marrow
T842	4288-4316	CL:0002540	denotes	bone marrow mesenchymal cell
T843	4300-4311	UBERON:0003104	denotes	mesenchymal
T844	4312-4332	GO:0030154	denotes	cell differentiation
T845	4372-4378	NCBITaxon:33208	denotes	animal
T846	4394-4398	_FRAGMENT	denotes	bone
T847	4411-4423	GO:1990523	denotes	regeneration
T848	4399-4409	GO:0008152	denotes	metabolism
T849	4443-4448	GO:0007568	denotes	aging
T1955	4460-4465	PR:000009279	denotes	Sam68
T1956	4469-4478	GO:0010467	denotes	Expressed
T1957	4497-4505	UBERON:0004288	denotes	Skeleton
T1958	4509-4518	UBERON:0000922	denotes	Embryonic
T1959	4519-4523	NCBITaxon:10088	denotes	Mice
T1960	4528-4533	PR:000009279	denotes	Sam68
T1961	4561-4570	GO:0010467	denotes	expressed
T1962	4608-4618	GO:0010467	denotes	expression
T1963	4706-4715	UBERON:0000922	denotes	embryonic
T1964	4716-4720	NCBITaxon:10088	denotes	mice
T1965	4777-4782	PR:000009279	denotes	Sam68
T1966	4783-4791	GO:0042571	denotes	antibody
T1967	4803-4810	NCBITaxon:9986	denotes	rabbits
T1968	4891-4896	NCBITaxon:10088	denotes	mouse
T1969	4897-4902	PR:000009279	denotes	Sam68
T1970	4917-4922	PR:000009279	denotes	Sam68
T1971	4960-4968	UBERON:0004288	denotes	skeleton
T1972	4978-4985	UBERON:0000479	denotes	tissues
T1973	5010-5014	NCBITaxon:10088	denotes	mice
T1974	5079-5095	GO:0005634	denotes	nucleus of cells
T1975	5114-5119	UBERON:0000955	denotes	brain
T1976	5121-5126	UBERON:0000948	denotes	heart
T1977	5132-5147	UBERON:0002108	denotes	small intestine
T1978	5175-5187	CL:0000138	denotes	chondrocytes
T1979	5195-5207	UBERON:0001706	denotes	nasal septum
T1980	5216-5225	UBERON:0002530	denotes	glandular
T1981	5226-5232	UBERON:0000479	denotes	tissue
T1982	5249-5264	UBERON:0001823	denotes	nasal cartilage
T1983	5297-5305	UBERON:0002412	denotes	vertebra
T1984	5310-5330	UBERON:0001066	denotes	intervertebral discs
T1985	5355-5364	_FRAGMENT	denotes	epiphysis
T1986	5403-5416	UBERON:0001437	denotes	of long bones
T1987	5382-5392	_FRAGMENT	denotes	metaphysis
T1988	5403-5416	UBERON:0001438	denotes	of long bones
T1989	5418-5425	GO:0005634	denotes	Nuclear
T1990	5451-5464	GO:0008283	denotes	proliferating
T1991	5465-5477	CL:0000138	denotes	chondrocytes
T1992	5482-5507	CL:0000743	denotes	hypertrophic chondrocytes
T1993	5533-5544	CL:0000062	denotes	osteoblasts
T1994	5575-5586	CL:0000092	denotes	osteoclasts
T1995	5641-5646	UBERON:0001977	denotes	serum
T1996	5663-5668	UBERON:0001977	denotes	serum
T1997	5790-5795	PR:000009279	denotes	Sam68
T1998	5819-5828	GO:0010467	denotes	expressed
T1999	5847-5852	NCBITaxon:10088	denotes	mouse
T2000	5853-5859	UBERON:0000922	denotes	embryo
T2001	5888-5898	GO:0010467	denotes	expression
T2403	7122-7127	PR:000009279	denotes	Sam68
T2404	7149-7154	NCBITaxon:10088	denotes	Mouse
T2405	7201-7206	PR:000009279	denotes	Sam68
T2406	7221-7226	PR:000009279	denotes	Sam68
T2407	7237-7241	NCBITaxon:10088	denotes	mice
T2408	7268-7273	SO:0000147	denotes	exons
T2409	7289-7294	PR:000009279	denotes	sam68
T2410	7295-7299	SO:0000704	denotes	gene
T2411	7363-7369	SO:0000417	denotes	domain
T2412	7413-7419	SO:0001023	denotes	allele
T2413	7485-7492	SO:0001026	denotes	genomic
T2414	7517-7522	PR:000009279	denotes	Sam68
T2415	7523-7534	SO:0000673	denotes	transcripts
T2416	7546-7551	SO:0000147	denotes	exons
T2417	7612-7617	PR:000009279	denotes	Sam68
T2418	7621-7625	NCBITaxon:10088	denotes	mice
T2419	7641-7646	PR:000009279	denotes	Sam68
T2420	7698-7703	PR:000009279	denotes	Sam68
T2421	7719-7729	GO:0042571	denotes	antibodies
T2422	7748-7754	NCBITaxon:9986	denotes	rabbit
T2423	7755-7760	UBERON:0001977	denotes	serum
T2424	7769-7774	PR:000009279	denotes	Sam68
T2425	7829-7835	NCBITaxon:9986	denotes	rabbit
T2426	7841-7846	PR:000009279	denotes	Sam68
T2427	7847-7855	GO:0042571	denotes	antibody
T2428	7913-7918	PR:000009279	denotes	Sam68
T2429	7966-7971	NCBITaxon:10088	denotes	mouse
T2430	7985-7990	PR:000009279	denotes	Sam68
T2431	8155-8160	PR:000009279	denotes	Sam68
T2432	8169-8173	GO:0016265	denotes	died
T2433	8177-8182	GO:0007567	denotes	birth
T2434	8202-8207	PR:000009279	denotes	Sam68
T2435	8211-8215	NCBITaxon:10088	denotes	mice
T2436	8247-8252	PR:000009279	denotes	Sam68
T2437	8279-8295	UBERON:0012101	denotes	perinatal period
T2438	8283-8288	GO:0007567	denotes	natal
T2439	8347-8352	PR:000009279	denotes	Sam68
T2440	8368-8377	GO:0010467	denotes	expressed
T2441	8400-8407	GO:0007067	denotes	mitosis
T2442	8421-8426	PR:000009279	denotes	Sam68
T2443	8430-8434	NCBITaxon:10088	denotes	mice
T2444	8510-8515	PR:000009279	denotes	Sam68
T2445	8519-8523	NCBITaxon:10088	denotes	mice
T2874	9877-9882	PR:000009279	denotes	Sam68
T2875	9903-9907	NCBITaxon:10088	denotes	Mice
T2876	9935-9938	PR:000027234	denotes	Src
T2877	9944-9951	NCBITaxon:33208	denotes	animals
T2878	9975-9985	GO:0008152	denotes	metabolism
T2879	10010-10015	PR:000009279	denotes	Sam68
T2880	10034-10037	PR:000027234	denotes	Src
T2881	10065-10070	PR:000009279	denotes	Sam68
T2882	10071-10075	NCBITaxon:10088	denotes	mice
T2883	10080-10088	UBERON:0004288	denotes	skeletal
T2884	10115-10120	PR:000009279	denotes	Sam68
T2885	10128-10133	PR:000009279	denotes	Sam68
T2886	10137-10141	NCBITaxon:10088	denotes	mice
T2887	10188-10196	UBERON:0004288	denotes	skeletal
T2888	10347-10351	NCBITaxon:10088	denotes	mice
T2889	10383-10387	NCBITaxon:10088	denotes	mice
T2890	10456-10461	PR:000009279	denotes	Sam68
T2891	10465-10469	NCBITaxon:10088	denotes	mice
T2892	10488-10493	PR:000009279	denotes	Sam68
T2893	10497-10501	NCBITaxon:10088	denotes	mice
T2894	10546-10551	_FRAGMENT	denotes	axial
T2895	10569-10577	UBERON:0011137	denotes	skeleton
T2896	10556-10577	UBERON:0002091	denotes	appendicular skeleton
T2897	10785-10793	UBERON:0001851	denotes	cortical
T2898	10830-10841	UBERON:0001438	denotes	metaphyseal
T2899	10872-10878	UBERON:0000981	denotes	femora
T2900	10895-10900	PR:000009279	denotes	Sam68
T2901	10904-10908	NCBITaxon:10088	denotes	mice
T2902	10935-10939	NCBITaxon:10088	denotes	mice
T2903	10976-10981	PR:000009279	denotes	Sam68
T2904	10985-10989	NCBITaxon:10088	denotes	mice
T2905	11013-11028	UBERON:0002483	denotes	trabecular bone
T2906	11072-11094	UBERON:0004621	denotes	fifth lumbar vertebrae
T2907	11115-11120	PR:000009279	denotes	Sam68
T2908	11124-11128	NCBITaxon:10088	denotes	mice
T2909	11144-11149	PR:000009279	denotes	Sam68
T2910	11153-11157	NCBITaxon:10088	denotes	mice
T2911	11194-11201	CHEBI:46662	denotes	mineral
T2912	11249-11254	NCBITaxon:10088	denotes	mouse
T2913	11333-11338	PR:000009279	denotes	Sam68
T2914	11346-11351	PR:000009279	denotes	Sam68
T2915	11355-11359	NCBITaxon:10088	denotes	mice
T2916	11436-11441	PR:000009279	denotes	Sam68
T2917	11445-11449	NCBITaxon:10088	denotes	mice
T2918	11514-11519	UBERON:0000981	denotes	femur
T2919	11524-11532	UBERON:0002412	denotes	vertebra
T2920	11540-11545	PR:000009279	denotes	Sam68
T2921	11549-11553	NCBITaxon:10088	denotes	mice
T2922	11560-11567	CHEBI:46662	denotes	mineral
T2923	11630-11634	NCBITaxon:10088	denotes	mice
T2924	11692-11699	UBERON:0000981	denotes	femoral
T2925	11704-11713	UBERON:0002412	denotes	vertebral
T2926	11741-11746	PR:000009279	denotes	Sam68
T2927	11784-11789	PR:000009279	denotes	Sam68
T2928	11793-11797	NCBITaxon:10088	denotes	mice
T2929	11841-11846	_FRAGMENT	denotes	axial
T2930	11864-11872	UBERON:0011137	denotes	skeleton
T2931	11851-11872	UBERON:0002091	denotes	appendicular skeleton
T3528	13392-13397	PR:000009279	denotes	Sam68
T3529	13401-13405	NCBITaxon:10088	denotes	Mice
T3530	13480-13489	UBERON:0004288	denotes	skeletons
T3531	13506-13510	NCBITaxon:10088	denotes	mice
T3532	13574-13580	NCBITaxon:9606	denotes	humans
T3533	13604-13614	NCBITaxon:1	denotes	individual
T3534	13736-13742	UBERON:0000479	denotes	tissue
T3535	13795-13800	PR:000009279	denotes	Sam68
T3536	13804-13808	NCBITaxon:10088	denotes	mice
T3537	13850-13854	NCBITaxon:10088	denotes	mice
T3538	13903-13908	PR:000009279	denotes	Sam68
T3539	13912-13916	NCBITaxon:10088	denotes	mice
T3540	14232-14237	PR:000009279	denotes	Sam68
T3541	14241-14245	NCBITaxon:10088	denotes	mice
T3542	14435-14439	NCBITaxon:10088	denotes	mice
T3543	14504-14514	UBERON:0000440	denotes	trabeculae
T3544	14555-14565	UBERON:0000440	denotes	trabeculae
T3545	14587-14592	PR:000009279	denotes	Sam68
T3546	14596-14600	NCBITaxon:10088	denotes	mice
T3547	14642-14646	NCBITaxon:10088	denotes	mice
T3961	15537-15552	GO:0046849	denotes	Bone Remodeling
T3962	15574-15579	PR:000009279	denotes	Sam68
T3963	15583-15587	NCBITaxon:10088	denotes	Mice
T3964	15671-15676	PR:000009279	denotes	Sam68
T3965	15680-15684	NCBITaxon:10088	denotes	mice
T3966	15729-15735	UBERON:0000981	denotes	femora
T3967	15740-15745	UBERON:0000979	denotes	tibia
T3968	15758-15768	CL:0000062	denotes	osteoblast
T3969	15773-15783	CL:0000092	denotes	osteoclast
T3970	15924-15935	CL:0000062	denotes	osteoblasts
T3971	15940-15962	PR:000001937	denotes	tartrate-resistant ALP
T3972	15964-15999	PR:000001937	denotes	tartrate-resistant acid phosphatase
T3973	15983-15987	CHEBI:37527	denotes	acid
T3974	16001-16005	PR:000001937	denotes	TRAP
T3975	16044-16055	CL:0000092	denotes	osteoclasts
T3976	16092-16097	PR:000009279	denotes	Sam68
T3977	16124-16129	PR:000009279	denotes	Sam68
T3978	16152-16156	NCBITaxon:10088	denotes	mice
T3979	16186-16190	PR:000001937	denotes	TRAP
T3980	16239-16244	PR:000009279	denotes	Sam68
T3981	16248-16252	NCBITaxon:10088	denotes	mice
T3982	16311-16316	PR:000009279	denotes	Sam68
T3983	16320-16324	NCBITaxon:10088	denotes	mice
T3984	16367-16377	CL:0000062	denotes	osteoblast
T3985	16382-16392	CL:0000092	denotes	osteoclast
T3986	16422-16427	PR:000009279	denotes	Sam68
T3987	16431-16435	NCBITaxon:10088	denotes	mice
T3988	16507-16517	CL:0000092	denotes	osteoclast
T3989	16523-16533	CL:0000062	denotes	osteoblast
T3990	17253-17263	UBERON:0002495	denotes	long bones
T3991	17371-17378	UBERON:0008883	denotes	osteoid
T3992	17392-17399	CHEBI:46662	denotes	mineral
T3993	17469-17474	PR:000009279	denotes	Sam68
T3994	17478-17482	NCBITaxon:10088	denotes	mice
T3995	17509-17514	PR:000009279	denotes	Sam68
T3996	17518-17522	NCBITaxon:10088	denotes	mice
T3997	17588-17594	UBERON:0002371	denotes	marrow
T3998	17632-17643	CL:0000062	denotes	osteoblasts
T3999	17657-17668	CL:0000092	denotes	osteoclasts
T4000	17682-17688	UBERON:0000479	denotes	tissue
T4001	17767-17772	PR:000009279	denotes	Sam68
T4002	17776-17780	NCBITaxon:10088	denotes	mice
T4003	17834-17840	UBERON:0002371	denotes	marrow
T4004	17871-17875	NCBITaxon:10088	denotes	mice
T4005	18041-18052	CL:0000062	denotes	osteoblasts
T4006	18056-18067	CL:0000092	denotes	osteoclasts
T4007	18097-18101	NCBITaxon:10088	denotes	mice
T4008	18215-18220	UBERON:0001977	denotes	serum
T4009	18375-18380	PR:000009279	denotes	Sam68
T4010	18384-18388	NCBITaxon:10088	denotes	mice
T4011	18407-18412	UBERON:0001977	denotes	Serum
T4012	18413-18421	CHEBI:50114	denotes	estrogen
T4013	18470-18474	NCBITaxon:10088	denotes	mice
T4014	18528-18541	PR:000001393	denotes	interleukin-6
T4015	18598-18608	GO:0065007	denotes	regulating
T4016	18629-18634	UBERON:0001977	denotes	serum
T4017	18658-18663	PR:000009279	denotes	Sam68
T4018	18671-18676	PR:000009279	denotes	Sam68
T4019	18680-18684	NCBITaxon:10088	denotes	mice
T4020	18703-18708	PR:000009279	denotes	Sam68
T4021	18712-18716	NCBITaxon:10088	denotes	mice
T4022	18767-18772	PR:000009279	denotes	Sam68
T4023	18776-18780	NCBITaxon:10088	denotes	mice
T4024	18791-18796	PR:000009279	denotes	Sam68
T4025	18800-18804	NCBITaxon:10088	denotes	mice
T4026	18902-18907	PR:000009279	denotes	Sam68
T4027	18911-18915	NCBITaxon:10088	denotes	mice
T4028	18949-18957	CHEBI:50114	denotes	estrogen
T4837	19042-19052	CL:0000062	denotes	Osteoblast
T4838	19062-19072	CL:0000092	denotes	Osteoclast
T4839	19097-19102	PR:000009279	denotes	Sam68
T4840	19106-19110	NCBITaxon:10088	denotes	Mice
T4841	19155-19160	UBERON:0007023	denotes	adult
T4842	19210-19220	CL:0000062	denotes	osteoblast
T4843	19224-19234	CL:0000092	denotes	osteoclast
T4844	19346-19351	PR:000009279	denotes	Sam68
T4845	19355-19359	NCBITaxon:10088	denotes	mice
T4846	19434-19439	PR:000009279	denotes	Sam68
T4847	19443-19454	CL:0000062	denotes	osteoblasts
T4848	19459-19470	CL:0000092	denotes	osteoclasts
T4849	19511-19530	UBERON:0007195	denotes	bone marrow stromal
T4850	19511-19536	CL:0010001	denotes	bone marrow stromal cells
T4851	19563-19568	PR:000009279	denotes	Sam68
T4852	19572-19576	NCBITaxon:10088	denotes	mice
T4853	19607-19617	CL:0000062	denotes	osteoblast
T4854	19788-19793	PR:000009279	denotes	Sam68
T4855	19797-19801	NCBITaxon:10088	denotes	mice
T4856	19834-19844	CL:0000057	denotes	fibroblast
T4857	19871-19872	CL:0000057	denotes	F
T4858	19962-19972	CL:0000062	denotes	osteoblast
T4859	20051-20056	PR:000009279	denotes	Sam68
T4860	20064-20069	PR:000009279	denotes	Sam68
T4861	20073-20077	NCBITaxon:10088	denotes	mice
T4862	20088-20103	PR:000003263	denotes	type I collagen
T4863	20158-20163	PR:000009279	denotes	Sam68
T4864	20167-20171	NCBITaxon:10088	denotes	mice
T4865	20203-20214	CL:0000092	denotes	osteoclasts
T4866	20241-20251	UBERON:0002495	denotes	long bones
T4867	20255-20260	PR:000009279	denotes	Sam68
T4868	20268-20273	PR:000009279	denotes	Sam68
T4869	20277-20281	NCBITaxon:10088	denotes	mice
T4870	20307-20311	PR:000001937	denotes	TRAP
T4871	20379-20385	UBERON:0001751	denotes	dentin
T4872	20420-20428	CHEBI:10545	denotes	electron
T4873	20485-20496	CL:0000092	denotes	osteoclasts
T4874	20530-20535	PR:000009279	denotes	Sam68
T4875	20539-20543	NCBITaxon:10088	denotes	mice
T4876	20560-20563	PR:000027234	denotes	Src
T4877	20569-20573	NCBITaxon:10088	denotes	mice
T5404	21660-21665	PR:000009279	denotes	Sam68
T5405	21675-21684	CL:0000136	denotes	Adipocyte
T5406	21714-21724	CL:0000062	denotes	Osteoblast
T5407	21768-21787	UBERON:0007195	denotes	bone marrow stromal
T5408	21768-21793	CL:0010001	denotes	bone marrow stromal cells
T5409	21812-21823	CL:0000062	denotes	osteoblasts
T5410	21828-21838	CL:0000136	denotes	adipocytes
T5411	21928-21937	CL:0000136	denotes	adipocyte
T5412	21975-21980	PR:000009279	denotes	Sam68
T5413	22001-22020	UBERON:0007195	denotes	bone marrow stromal
T5414	22001-22026	CL:0010001	denotes	bone marrow stromal cells
T5415	22054-22064	GO:0001503	denotes	osteogenic
T5416	22076-22086	GO:0060612	denotes	adipogenic
T5417	22123-22128	PR:000009279	denotes	Sam68
T5418	22146-22154	GO:0065007	denotes	regulate
T5419	22208-22215	GO:0065007	denotes	control
T5420	22249-22275	UBERON:0000013	denotes	sympathetic nervous system
T5421	22352-22357	PR:000009279	denotes	Sam68
T5422	22365-22378	_FRAGMENT	denotes	regulation of
T5423	22389-22404	GO:0045595	denotes	differentiation
T5424	22379-22388	CL:0000136	denotes	adipocyte
T5425	22449-22454	PR:000009279	denotes	Sam68
T5426	22462-22467	PR:000009279	denotes	Sam68
T5427	22471-22478	UBERON:0000922	denotes	embryos
T5428	22492-22497	PR:000009279	denotes	Sam68
T5429	22531-22541	CL:0000136	denotes	adipocytes
T5430	22585-22597	CHEBI:8228	denotes	pioglitazone
T5431	22608-22620	GO:0060612	denotes	adipogenesis
T5432	22691-22703	GO:0060612	denotes	adipogenesis
T5433	22705-22717	GO:0060612	denotes	Adipogenesis
T5434	22781-22786	PR:000009279	denotes	Sam68
T5435	22844-22849	PR:000009279	denotes	Sam68
T5436	22853-22862	CL:0000136	denotes	adipocyte
T5437	22895-22905	GO:0010467	denotes	expression
T5438	22949-22954	PR:000013058	denotes	PPARγ
T5439	22959-22963	PR:000009365	denotes	KLF5
T5440	22980-22985	PR:000009279	denotes	Sam68
T5441	23023-23028	PR:000009279	denotes	Sam68
T5442	23063-23075	GO:0060612	denotes	adipogenesis
T5443	23094-23099	PR:000009279	denotes	Sam68
T5444	23174-23179	PR:000009279	denotes	Sam68
T5445	23183-23187	NCBITaxon:10088	denotes	mice
T5446	23262-23267	PR:000009279	denotes	Sam68
T5447	23268-23277	GO:0065007	denotes	modulates
T5448	23282-23300	_FRAGMENT	denotes	differentiation of
T5449	23313-23318	GO:0030154	denotes	cells
T5450	23301-23312	UBERON:0003104	denotes	mesenchymal
T5451	23301-23318	CL:0000134	denotes	mesenchymal cells
T5452	24321-24330	UBERON:0000922	denotes	embryonic
T5453	24321-24330	_FRAGMENT	denotes	embryonic
T5454	24369-24374	CL:0002321	denotes	cells
T5455	24331-24342	UBERON:0003104	denotes	mesenchymal
T5456	24331-24342	_FRAGMENT	denotes	mesenchymal
T5457	24369-24374	CL:0000134	denotes	cells
T5458	24402-24407	PR:000000164	denotes	BMP-2
T5459	24416-24426	CL:0000062	denotes	osteoblast
T5460	24498-24508	GO:0010467	denotes	expression
T5461	24516-24527	PR:000030444	denotes	osteocalcin
T5462	24529-24532	PR:000030444	denotes	OCN
T5463	24534-24538	SO:0000704	denotes	gene
T5464	24583-24594	GO:0009294	denotes	transfected
T5465	24665-24672	SO:0000313	denotes	hairpin
T5466	24681-24686	PR:000009279	denotes	Sam68
T5467	24716-24725	CHEBI:17939	denotes	puromycin
T5468	24731-24741	GO:0010467	denotes	expression
T5469	24745-24750	PR:000009279	denotes	Sam68
T5470	24826-24833	PR:000003676	denotes	β-actin
T5471	24868-24878	CL:0000062	denotes	Osteoblast
T5472	24919-24929	GO:0010467	denotes	expressing
T5473	24982-24987	PR:000000164	denotes	BMP-2
T5474	25017-25027	GO:0010467	denotes	expression
T5475	25031-25034	PR:000030444	denotes	OCN
T5476	25039-25046	PR:000003676	denotes	β-actin
T5477	25109-25119	GO:0010467	denotes	expressing
T5478	25154-25164	CL:0000062	denotes	osteoblast
T5479	25223-25233	GO:0010467	denotes	expression
T5480	25237-25240	PR:000030444	denotes	OCN
T5481	26164-26169	PR:000009279	denotes	Sam68
T5482	26173-26192	UBERON:0007195	denotes	bone marrow stromal
T5483	26173-26198	CL:0010001	denotes	bone marrow stromal cells
T5484	26239-26256	SO:0002031	denotes	short hairpin RNA
T5485	26258-26263	SO:0002031	denotes	shRNA
T5486	26337-26341	NCBITaxon:10088	denotes	mice
T5487	26369-26375	UBERON:0002371	denotes	marrow
T5488	26458-26463	PR:000009279	denotes	Sam68
T5489	26471-26476	PR:000009279	denotes	Sam68
T5490	26480-26484	NCBITaxon:10088	denotes	mice
T5491	26547-26553	UBERON:0000479	denotes	tissue
T5492	26577-26583	UBERON:0002371	denotes	marrow
T5493	26584-26594	CL:0000136	denotes	adipocytes
T5494	26641-26653	CHEBI:51217	denotes	fluorochrome
T5495	26722-26727	PR:000009279	denotes	Sam68
T5496	26731-26735	NCBITaxon:10088	denotes	mice
T5497	26768-26783	UBERON:0002483	denotes	trabecular bone
T5498	26849-26855	UBERON:0002371	denotes	marrow
T5499	26895-26907	CHEBI:51217	denotes	fluorochrome
T5500	26975-26980	UBERON:0001474	denotes	bones
T5501	26997-27002	PR:000009279	denotes	Sam68
T5502	27006-27010	NCBITaxon:10088	denotes	mice
T5503	27056-27060	NCBITaxon:10088	denotes	mice
T5504	27109-27114	PR:000009279	denotes	Sam68
T5505	27115-27124	GO:0065007	denotes	regulates
T5506	27129-27147	_FRAGMENT	denotes	differentiation of
T5507	27172-27177	GO:0030154	denotes	cells
T5508	27148-27159	UBERON:0002371	denotes	bone marrow
T5509	27148-27177	CL:0002540	denotes	bone marrow mesenchymal cells
T5510	27160-27171	UBERON:0003104	denotes	mesenchymal
T5511	27189-27198	CL:0000136	denotes	adipocyte
T5512	27227-27237	CL:0000062	denotes	osteoblast
T5513	27257-27262	GO:0007568	denotes	aging
T6677	28016-28021	PR:000009279	denotes	Sam68
T6678	28028-28036	GO:0065007	denotes	modulate
T6679	28037-28048	UBERON:0002371	denotes	bone marrow
T6680	28037-28071	CL:0002540	denotes	bone marrow mesenchymal stem cells
T6681	28049-28060	UBERON:0003104	denotes	mesenchymal
T6682	28079-28084	PR:000009279	denotes	Sam68
T6683	28088-28092	NCBITaxon:10088	denotes	mice
T6684	28198-28203	PR:000009279	denotes	Sam68
T6685	28207-28211	NCBITaxon:10088	denotes	mice
T6686	28263-28268	PR:000009279	denotes	Sam68
T6687	28368-28375	NCBITaxon:40674	denotes	mammals
T6688	28387-28392	PR:000009279	denotes	Sam68
T6689	28396-28403	NCBITaxon:33208	denotes	animals
T6690	28435-28440	GO:0007568	denotes	aging
T6691	28446-28464	_FRAGMENT	denotes	differentiation of
T6692	28482-28487	GO:0030154	denotes	cells
T6693	28465-28476	UBERON:0002371	denotes	bone marrow
T6694	28465-28476	_FRAGMENT	denotes	bone marrow
T6695	28482-28487	CL:0002092	denotes	cells
T6696	28477-28487	CL:0000034	denotes	stem cells
T6697	28502-28507	PR:000009279	denotes	Sam68
T6698	28511-28515	NCBITaxon:10088	denotes	mice
T6699	28520-28529	UBERON:0000922	denotes	embryonic
T6700	28520-28529	_FRAGMENT	denotes	embryonic
T6701	28568-28573	CL:0002321	denotes	cells
T6702	28530-28541	UBERON:0003104	denotes	mesenchymal
T6703	28530-28541	_FRAGMENT	denotes	mesenchymal
T6704	28568-28573	CL:0000134	denotes	cells
T6705	28597-28602	PR:000009279	denotes	Sam68
T6706	28603-28608	SO:0002031	denotes	shRNA
T6707	28639-28649	CL:0000062	denotes	osteoblast
T6708	28711-28716	PR:000009279	denotes	Sam68
T6709	28726-28736	CL:0000062	denotes	osteoblast
T6710	28804-28809	PR:000009279	denotes	Sam68
T6711	28813-28820	NCBITaxon:33208	denotes	animals
T6712	28863-28872	CL:0000136	denotes	adipocyte
T6713	28903-28908	PR:000009279	denotes	Sam68
T6714	28969-28974	PR:000009279	denotes	Sam68
T6715	28981-28989	GO:0065007	denotes	regulate
T6716	29010-29020	GO:0060612	denotes	adipogenic
T6717	29025-29035	GO:0001503	denotes	osteogenic
T6718	29059-29070	UBERON:0002371	denotes	bone marrow
T6719	29071-29082	UBERON:0003104	denotes	mesenchymal
T6720	29084-29089	PR:000009279	denotes	Sam68
T6721	29098-29108	GO:0010467	denotes	expression
T6722	29148-29153	NCBITaxon:10088	denotes	mouse
T6723	29154-29160	UBERON:0000922	denotes	embryo
T6724	29215-29220	PR:000009279	denotes	Sam68
T6725	29239-29248	GO:0010467	denotes	expressed
T6726	29266-29271	PR:000009279	denotes	Sam68
T6727	29288-29293	UBERON:0000955	denotes	brain
T6728	29295-29300	UBERON:0000948	denotes	heart
T6729	29306-29315	UBERON:0000160	denotes	intestine
T6730	29342-29347	UBERON:0002107	denotes	liver
T6731	29359-29365	UBERON:0002113	denotes	kidney
T6732	29388-29406	UBERON:0000323	denotes	late-stage embryos
T6733	29413-29423	GO:0010467	denotes	expression
T6734	29483-29488	PR:000009279	denotes	Sam68
T6735	29492-29499	CL:0000540	denotes	neurons
T6736	29531-29541	UBERON:0000160	denotes	intestinal
T6737	29531-29545	PR:000013434	denotes	intestinal SIK
T6738	29546-29552	UBERON:0000310	denotes	breast
T6739	29546-29565	PR:000013434	denotes	breast tumor kinase
T6740	29576-29586	GO:0010467	denotes	expression
T6741	29590-29595	PR:000009279	denotes	Sam68
T6742	29615-29620	GO:0007568	denotes	aging
T6743	29621-29640	UBERON:0007195	denotes	bone marrow stromal
T6744	29621-29646	CL:0010001	denotes	bone marrow stromal cells
T6745	29653-29665	GO:0007568	denotes	senescencing
T6746	29714-29719	PR:000009279	denotes	Sam68
T6747	29723-29735	CL:0000138	denotes	chondrocytes
T6748	29737-29748	CL:0000062	denotes	osteoblasts
T6749	29753-29764	CL:0000092	denotes	osteoclasts
T6750	29842-29850	UBERON:0004288	denotes	skeletal
T6751	29842-29862	GO:0001501	denotes	skeletal development
T6752	29868-29873	PR:000009279	denotes	Sam68
T6753	29877-29881	NCBITaxon:10088	denotes	mice
T6754	29960-29966	SO:0000417	denotes	domain
T6755	30014-30019	PR:000009279	denotes	Sam68
T6756	30023-30027	NCBITaxon:10088	denotes	mice
T6757	30040-30049	UBERON:0000113	denotes	adulthood
T6758	30120-30125	PR:000009279	denotes	Sam68
T6759	30213-30218	PR:000009280	denotes	SLM-1
T6760	30223-30228	PR:000009281	denotes	SLM-2
T6761	30250-30255	PR:000009279	denotes	Sam68
T6762	30279-30288	UBERON:0000922	denotes	embryonic
T6763	30279-30300	GO:0009790	denotes	embryonic development
T6764	30329-30334	PR:000009279	denotes	Sam68
T6765	30351-30356	PR:000009279	denotes	Sam68
T6766	30387-30392	PR:000009279	denotes	Sam68
T6767	30507-30512	UBERON:0007023	denotes	Adult
T6768	30513-30518	PR:000009279	denotes	Sam68
T6769	30522-30526	NCBITaxon:10088	denotes	mice
T6770	30541-30550	UBERON:0000104	denotes	life span
T6771	30583-30588	PR:000009279	denotes	Sam68
T6772	30619-30624	PR:000009279	denotes	Sam68
T6773	30740-30744	PR:000007598	denotes	FosB
T6774	30748-30752	NCBITaxon:10088	denotes	mice
T6775	30759-30764	UBERON:0001977	denotes	Serum
T6776	30775-30783	CHEBI:50114	denotes	estrogen
T6777	30797-30802	GO:0007568	denotes	aging
T6778	30803-30808	PR:000009279	denotes	Sam68
T6779	30878-30883	PR:000009279	denotes	Sam68
T6780	30905-30910	PR:000009279	denotes	Sam68
T6781	31053-31058	GO:0007568	denotes	aging
T6782	31251-31259	UBERON:0004288	denotes	skeletal
T6783	31286-31291	PR:000009279	denotes	Sam68
T6784	31299-31304	PR:000009279	denotes	Sam68
T6785	31308-31312	NCBITaxon:10088	denotes	mice
T6786	31357-31362	PR:000009279	denotes	Sam68
T6787	31366-31370	NCBITaxon:10088	denotes	mice
T6788	31469-31479	CL:0000062	denotes	osteoblast
T6789	31484-31494	CL:0000092	denotes	osteoclast
T6790	31532-31537	PR:000009279	denotes	Sam68
T6791	31538-31548	GO:0065007	denotes	regulatory
T6792	31558-31561	PR:000027234	denotes	Src
T6793	31633-31638	PR:000009279	denotes	Sam68
T6794	31642-31653	CL:0000092	denotes	osteoclasts
T6795	31667-31670	PR:000027234	denotes	Src
T6796	31715-31730	GO:0046849	denotes	bone remodeling
T6797	31736-31739	PR:000027234	denotes	Src
T6798	31743-31747	NCBITaxon:10088	denotes	mice
T6799	31748-31752	GO:0016265	denotes	died
T6800	31852-31862	CL:0000092	denotes	osteoclast
T6801	31910-31921	CL:0000092	denotes	osteoclasts
T6802	31937-31942	PR:000009279	denotes	Sam68
T6803	31950-31955	PR:000009279	denotes	Sam68
T6804	31959-31963	NCBITaxon:10088	denotes	mice
T6805	31975-31981	UBERON:0001751	denotes	dentin
T6806	32042-32047	PR:000009279	denotes	Sam68
T6807	32051-32062	CL:0000092	denotes	osteoclasts
T6808	32085-32090	PR:000009279	denotes	Sam68
T6809	32094-32105	CL:0000092	denotes	osteoclasts
T6810	32202-32212	GO:0008152	denotes	metabolism
T6811	32229-32234	PR:000009279	denotes	Sam68
T6812	32238-32242	NCBITaxon:10088	denotes	mice
T6813	32301-32306	PR:000009279	denotes	Sam68
T6814	32310-32314	NCBITaxon:10088	denotes	mice
T6815	32347-32362	GO:0045453	denotes	bone resorption
T6816	32435-32450	GO:0045453	denotes	bone resorption
T6817	32472-32482	CL:0000092	denotes	osteoclast
T6818	32571-32576	PR:000009279	denotes	Sam68
T6819	32580-32584	NCBITaxon:10088	denotes	mice
T6820	32678-32683	PR:000009279	denotes	Sam68
T6821	32687-32691	NCBITaxon:10088	denotes	mice
T6822	32692-32702	CL:0000092	denotes	osteoclast
T6823	32741-32745	UBERON:0000104	denotes	life
T6824	32834-32852	_FRAGMENT	denotes	differentiation of
T6825	32881-32886	GO:0030154	denotes	cells
T6826	32853-32860	_FRAGMENT	denotes	primary
T6827	32881-32886	CL:0000001	denotes	cells
T6828	32861-32880	UBERON:0007195	denotes	bone marrow stromal
T6829	32861-32886	CL:0010001	denotes	bone marrow stromal cells
T6835	33034-33039	PR:000009279	denotes	Sam68
T6836	33043-33047	NCBITaxon:10088	denotes	mice
T6837	33125-33132	_FRAGMENT	denotes	primary
T6838	33153-33158	CL:0000001	denotes	cells
T6839	33133-33152	UBERON:0007195	denotes	bone marrow stromal
T6840	33133-33158	CL:0010001	denotes	bone marrow stromal cells
T6841	33169-33174	PR:000009279	denotes	Sam68
T6842	33178-33182	NCBITaxon:10088	denotes	mice
T6843	33220-33229	UBERON:0000922	denotes	embryonic
T6844	33220-33229	_FRAGMENT	denotes	embryonic
T6845	33268-33273	CL:0002321	denotes	cells
T6846	33230-33241	UBERON:0003104	denotes	mesenchymal
T6847	33230-33241	_FRAGMENT	denotes	mesenchymal
T6848	33268-33273	CL:0000134	denotes	cells
T6849	33297-33302	PR:000009279	denotes	Sam68
T6850	33303-33308	SO:0002031	denotes	shRNA
T6851	33335-33346	CL:0000062	denotes	osteoblasts
T6852	33352-33356	PR:000000164	denotes	BMP2
T6853	33381-33386	PR:000009279	denotes	Sam68
T6854	33390-33394	NCBITaxon:10088	denotes	mice
T6855	33416-33427	UBERON:0002371	denotes	bone marrow
T6856	33455-33460	PR:000009279	denotes	Sam68
T6857	33465-33469	NCBITaxon:10088	denotes	mice
T6858	33484-33493	CL:0000136	denotes	adipocyte
T6859	33525-33530	PR:000009279	denotes	Sam68
T6860	33531-33540	GO:0065007	denotes	regulates
T6861	33546-33555	CL:0000136	denotes	adipocyte
T6862	33560-33570	CL:0000062	denotes	osteoblast
T6863	33612-33617	PR:000009279	denotes	Sam68
T6864	33654-33662	GO:0065007	denotes	regulate
T6865	33663-33674	UBERON:0003104	denotes	mesenchymal
T6866	33663-33679	CL:0000134	denotes	mesenchymal cell
T6867	33675-33695	GO:0030154	denotes	cell differentiation
T6868	33767-33776	GO:0065007	denotes	regulates
T6869	33812-33822	CL:0000062	denotes	osteoblast
T6870	33846-33849	PR:000027234	denotes	Src
T6871	33853-33857	NCBITaxon:10088	denotes	mice
T6872	33927-33932	PR:000009279	denotes	Sam68
T6873	33936-33940	NCBITaxon:10088	denotes	mice
T6874	33966-33975	GO:0065007	denotes	regulated
T6875	33979-33982	PR:000027234	denotes	Src
T6876	34012-34021	GO:0065007	denotes	regulates
T6877	34022-34037	GO:0045453	denotes	bone resorption
T6878	34068-34094	UBERON:0000013	denotes	sympathetic nervous system
T6879	34111-34122	CL:0000062	denotes	osteoblasts
T6880	34203-34208	PR:000002107	denotes	RANKL
T6881	34225-34236	CL:0000092	denotes	osteoclasts
T6882	34296-34301	PR:000009279	denotes	Sam68
T6883	34305-34309	NCBITaxon:10088	denotes	mice
T6884	34335-34339	NCBITaxon:10088	denotes	mice
T6885	34479-34484	PR:000009279	denotes	Sam68
T6886	34488-34492	NCBITaxon:10088	denotes	mice
T6887	34568-34573	UBERON:0001977	denotes	serum
T6888	34577-34582	PR:000009279	denotes	Sam68
T6889	34586-34590	NCBITaxon:10088	denotes	mice
T6890	34620-34625	PR:000009279	denotes	Sam68
T6891	34633-34643	GO:0065007	denotes	regulating
T6892	34649-34659	GO:0008152	denotes	metabolism
T6893	34704-34709	PR:000009279	denotes	Sam68
T6894	34757-34772	GO:0045453	denotes	bone resorption
T6895	34781-34807	UBERON:0000013	denotes	sympathetic nervous system
T6896	34831-34836	PR:000009279	denotes	Sam68
T6897	34844-34854	CL:0000062	denotes	osteoblast
T6898	34868-34877	CL:0000136	denotes	adipocyte
T6899	34950-34955	PR:000009279	denotes	Sam68
T6900	34964-34974	GO:0008152	denotes	metabolism
T6901	34979-34990	UBERON:0002371	denotes	bone marrow
T6902	34979-35012	CL:0002540	denotes	bone marrow mesenchymal stem cell
T6903	34991-35002	UBERON:0003104	denotes	mesenchymal
T6904	35008-35028	GO:0030154	denotes	cell differentiation
T6905	35061-35066	PR:000009279	denotes	Sam68
T6906	35070-35074	NCBITaxon:10088	denotes	mice
T6907	35086-35096	CHEBI:35222	denotes	inhibitors
T6908	35100-35105	PR:000009279	denotes	Sam68
T6909	35186-35191	PR:000009279	denotes	Sam68
T6910	35192-35202	GO:0010467	denotes	expression
T6911	35242-35248	NCBITaxon:9606	denotes	humans
T6912	35281-35287	UBERON:0002371	denotes	marrow
T6913	35288-35297	CL:0000136	denotes	adipocyte
T6914	35362-35368	NCBITaxon:33208	denotes	animal
T6915	35384-35389	GO:0007568	denotes	aging
T8808	35572-35581	UBERON:0000922	denotes	embryonic
T8809	35582-35586	NCBITaxon:10088	denotes	mice
T8810	35611-35619	GO:0007565	denotes	pregnant
T8811	35933-35938	PR:000009279	denotes	Sam68
T8812	35939-35947	GO:0042571	denotes	antibody
T8813	36000-36011	CHEBI:51686	denotes	hematoxylin
T8814	36013-36018	UBERON:0000922	denotes	Adult
T8815	36019-36023	NCBITaxon:10088	denotes	mice
T8816	36043-36053	UBERON:0001179	denotes	peritoneal
T8817	36076-36083	CHEBI:51903	denotes	calcein
T8818	36107-36119	CHEBI:27902	denotes	tetracycline
T8819	36267-36272	UBERON:0000981	denotes	femur
T8820	36277-36282	UBERON:0000979	denotes	tibia
T8821	36324-36327	CHEBI:34840	denotes	MMA
T8822	36334-36341	CHEBI:60004	denotes	mixture
T8823	36349-36352	CHEBI:34840	denotes	MMA
T8824	36361-36379	CHEBI:34288	denotes	glycolmethacrylate
T8825	36381-36384	CHEBI:34288	denotes	GMA
T8826	36417-36420	CHEBI:34840	denotes	MMA
T8827	36430-36437	UBERON:0000479	denotes	tissues
T8828	36544-36547	CHEBI:34840	denotes	MMA
T8829	36548-36551	CHEBI:34288	denotes	GMA
T8830	36578-36582	PR:000001937	denotes	TRAP
T8831	37017-37024	CHEBI:46662	denotes	Mineral
T9198	37055-37059	NCBITaxon:10088	denotes	mice
T9199	37092-37097	PR:000009279	denotes	sam68
T9200	37098-37102	SO:0000704	denotes	gene
T9201	37141-37146	PR:000009279	denotes	Sam68
T9202	37147-37152	SO:0000147	denotes	exons
T9203	37188-37195	SO:0001026	denotes	genomic
T9204	37222-37227	PR:000009279	denotes	Sam68
T9205	37259-37264	PR:000009279	denotes	Sam68
T9206	37265-37272	SO:0001026	denotes	genomic
T9207	37309-37313	SO:0000147	denotes	exon
T9208	37320-37332	SO:0000852	denotes	part of exon
T9209	37354-37366	SO:0000852	denotes	part of exon
T9210	37373-37377	SO:0000147	denotes	exon
T9211	37594-37600	SO:0000112	denotes	primer
T9212	37971-37987	SO:0001644	denotes	targeting vector
T9213	37993-37998	PR:000009279	denotes	Sam68
T9214	38008-38012	SO:0000147	denotes	exon
T9215	38019-38031	SO:0000852	denotes	part of exon
T9216	38041-38049	CHEBI:7507	denotes	neomycin
T9217	38060-38073	SO:0005853	denotes	gene cassette
T9218	38172-38179	SO:0000155	denotes	plasmid
T9219	38205-38214	UBERON:0000922	denotes	embryonic
T9220	38205-38219	_FRAGMENT	denotes	embryonic stem
T9221	38225-38230	CL:0002322	denotes	cells
T9222	38221-38223	_FRAGMENT	denotes	ES
T9223	38252-38254	CL:0002322	denotes	ES
T9224	38328-38333	PR:000009279	denotes	Sam68
T9225	38341-38347	SO:0001023	denotes	allele
T9226	38394-38402	CL:0002322	denotes	ES cells
T9227	38441-38452	UBERON:0000358	denotes	blastocysts
T9228	38504-38511	NCBITaxon:33208	denotes	animals
T9229	38538-38542	UBERON:0010166	denotes	coat
T9230	38554-38559	GO:0007618	denotes	mated
T9231	38572-38576	NCBITaxon:10088	denotes	mice
T9232	38622-38626	NCBITaxon:10088	denotes	mice
T9233	38670-38674	NCBITaxon:10088	denotes	mice
T9234	38705-38709	NCBITaxon:10088	denotes	mice
T9235	38811-38815	NCBITaxon:10088	denotes	mice
T9703	38913-38918	NCBITaxon:10088	denotes	mouse
T9704	39035-39041	NCBITaxon:33208	denotes	Animal
T9705	39048-39055	SO:0001026	denotes	Genomic
T9706	39078-39082	UBERON:0002415	denotes	tail
T9707	39130-39137	SO:0001026	denotes	genomic
T9708	39368-39373	PR:000009279	denotes	sam68
T9709	39374-39380	SO:0001023	denotes	allele
T9710	39399-39406	SO:0001026	denotes	genomic
T9711	39532-39537	PR:000009279	denotes	sam68
T9712	39547-39553	SO:0001023	denotes	allele
T9713	39572-39579	SO:0001026	denotes	genomic
T9934	39711-39716	UBERON:0001977	denotes	serum
T9935	39733-39738	PR:000009279	denotes	Sam68
T9936	39746-39751	PR:000009279	denotes	Sam68
T9937	39755-39759	NCBITaxon:10088	denotes	mice
T9938	39849-39853	NCBITaxon:10088	denotes	Mice
T9939	39889-39899	CHEBI:38867	denotes	anesthetic
T9940	40224-40228	NCBITaxon:10088	denotes	mice
T9941	40344-40349	UBERON:0000981	denotes	femur
T9942	40354-40376	UBERON:0004620	denotes	fourth lumbar vertebra
T9943	40399-40406	UBERON:0000479	denotes	tissues
T9944	40458-40475	UBERON:0004377	denotes	distal metaphysis
T9945	40817-40822	UBERON:0001977	denotes	Serum
T9946	40877-40883	NCBITaxon:9989	denotes	Rodent
T9947	41023-41028	UBERON:0001977	denotes	serum
T9948	41079-41092	CHEBI:16469	denotes	17β estradiol
T9949	41203-41216	PR:000001393	denotes	interleukin-6
T10319	41257-41267	CL:0000062	denotes	osteoblast
T10320	41272-41282	CL:0000092	denotes	osteoclast
T10321	41293-41304	UBERON:0002371	denotes	Bone marrow
T10322	41326-41331	UBERON:0000979	denotes	tibia
T10323	41336-41342	UBERON:0000981	denotes	femora
T10324	41366-41371	PR:000009279	denotes	Sam68
T10325	41379-41384	PR:000009279	denotes	Sam68
T10326	41388-41392	NCBITaxon:10088	denotes	mice
T10327	41403-41410	UBERON:0003891	denotes	stromal
T10328	41403-41416	CL:0000499	denotes	stromal cells
T10329	41673-41683	CL:0000062	denotes	osteoblast
T10330	41692-41696	SO:0000704	denotes	gene
T10331	41692-41707	GO:0010467	denotes	gene expression
T10332	41748-41759	CL:0000092	denotes	Osteoclasts
T10333	41791-41801	UBERON:0002495	denotes	long bones
T10334	41814-41819	PR:000009279	denotes	Sam68
T10335	41827-41832	PR:000009279	denotes	Sam68
T10336	41836-41840	NCBITaxon:10088	denotes	mice
T10337	41947-41953	UBERON:0001751	denotes	dentin
T10338	42112-42116	PR:000001937	denotes	TRAP
T10339	42137-42143	UBERON:0001751	denotes	Dentin
T10340	42205-42223	CHEBI:18219	denotes	ammonium hydroxide
T10341	42303-42311	CHEBI:10545	denotes	electron
T10342	42331-42339	CHEBI:10545	denotes	Electron
T10676	42681-42686	NCBITaxon:10088	denotes	mouse
T10677	42687-42696	UBERON:0000922	denotes	embryonic
T10678	42697-42707	CL:0000057	denotes	fibroblast
T10679	42725-42734	CL:0000136	denotes	adipocyte
T10680	42789-42796	UBERON:0000922	denotes	embryos
T10681	42879-42888	CL:0000136	denotes	adipocyte
T10682	42973-42987	CL:0000010	denotes	Cultured cells
T10786	43073-43085	GO:0060612	denotes	adipogenesis
T10787	43089-43094	PR:000009279	denotes	Sam68
T10788	43146-43153	CHEBI:33893	denotes	reagent
T10789	43267-43286	GO:0001171	denotes	reverse-transcribed
T10790	43413-43420	SO:0000112	denotes	primers
T10791	43443-43453	GO:0060612	denotes	adipogenic
T10792	43471-43475	PR:000009365	denotes	KLF5
T10793	43540-43545	PR:000013058	denotes	PPARγ
T10794	43623-43630	PR:000003676	denotes	β-Actin
T10795	43705-43710	PR:000009279	denotes	Sam68
T11047	43791-43796	PR:000009279	denotes	Sam68
T11048	43843-43848	SO:0002031	denotes	shRNA
T11049	43858-43864	SO:0000985	denotes	duplex
T11050	43966-43971	NCBITaxon:10088	denotes	mouse
T11051	43972-43977	PR:000009279	denotes	Sam68
T11052	44143-44156	GO:0009294	denotes	Transfections
T11053	44244-44250	SO:0000440	denotes	vector
T11054	44266-44278	GO:0009294	denotes	transfection
T11055	44320-44329	CHEBI:17939	denotes	puromycin
T11056	44385-44390	PR:000009279	denotes	Sam68
T11057	44397-44405	GO:0042571	denotes	antibody
T11205	44408-44418	GO:0001503	denotes	Osteogenic
T11206	44468-44478	GO:0001503	denotes	osteogenic
T11207	44545-44551	UBERON:0000479	denotes	tissue
T11208	44683-44688	PR:000000164	denotes	BMP-2
T11209	44790-44801	PR:000030444	denotes	osteocalcin
T11210	44803-44810	PR:000003676	denotes	β-actin
T11211	44822-44826	SO:0000704	denotes	gene
T11212	44822-44837	GO:0010467	denotes	gene expression
T11213	44863-44868	PR:000000164	denotes	BMP-2
T6830	32903-32908	PR:000009279	denotes	Sam68
T6831	32916-32921	PR:000009279	denotes	Sam68
T6832	32925-32929	NCBITaxon:10088	denotes	mice
T6833	32940-32950	CL:0000062	denotes	osteoblast
T6834	32971-32981	GO:0001503	denotes	osteogenic
R1729	T2930	T2929	_lexicallyChainedTo	skeleton,axial
R3366	T5423	T5422	_lexicallyChainedTo	differentiation,regulation of
R3367	T5449	T5448	_lexicallyChainedTo	cells,differentiation of
R3368	T5454	T5453	_lexicallyChainedTo	cells,embryonic
R3369	T5457	T5456	_lexicallyChainedTo	cells,mesenchymal
R3370	T5507	T5506	_lexicallyChainedTo	cells,differentiation of
R4086	T6692	T6691	_lexicallyChainedTo	cells,differentiation of
R4087	T6695	T6694	_lexicallyChainedTo	cells,bone marrow
R4088	T6701	T6700	_lexicallyChainedTo	cells,embryonic
R4089	T6704	T6703	_lexicallyChainedTo	cells,mesenchymal
R4090	T6825	T6824	_lexicallyChainedTo	cells,differentiation of
R4091	T6827	T6826	_lexicallyChainedTo	cells,primary
R4092	T6838	T6837	_lexicallyChainedTo	cells,primary
R4093	T6845	T6844	_lexicallyChainedTo	cells,embryonic
R4094	T6848	T6847	_lexicallyChainedTo	cells,mesenchymal
R5768	T9221	T9220	_lexicallyChainedTo	cells,embryonic stem
R5769	T9221	T9222	_lexicallyChainedTo	cells,ES
R331	T745	T744	_lexicallyChainedTo	cells,response of
R332	T757	T756	_lexicallyChainedTo	cells,response of
R333	T828	T827	_lexicallyChainedTo	cells,differentiation of
R334	T847	T846	_lexicallyChainedTo	regeneration,bone
R1151	T1986	T1985	_lexicallyChainedTo	of long bones,epiphysis
R1152	T1988	T1987	_lexicallyChainedTo	of long bones,metaphysis
R1728	T2895	T2894	_lexicallyChainedTo	skeleton,axial

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T850	20-28	UBERON:0004288	denotes	skeletal
T851	20-40	GO:0001501	denotes	skeletal development
T852	67-78	CL:0000062	denotes	osteoblasts
T853	125-136	CL:0000092	denotes	osteoclasts
T854	173-177	UBERON_EXT:bone_element_or_tissue	denotes	bone
T855	187-195	UBERON:0004288	denotes	skeletal
T856	206-210	UBERON_EXT:bone_element_or_tissue	denotes	bone
T857	263-274	CL:0000062	denotes	osteoblasts
T858	279-290	CL:0000092	denotes	osteoclasts
T859	327-335	UBERON:0004288	denotes	skeletal
T860	336-341	GO:0007568	denotes	aging
T861	387-397	CL:0000092	denotes	osteoclast
T862	403-413	CL:0000062	denotes	osteoblast
T863	445-449	UBERON_EXT:bone_element_or_tissue	denotes	bone
T864	489-493	UBERON_EXT:bone_element_or_tissue	denotes	bone
T865	539-544	GO:0007568	denotes	aging
T866	577-585	OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process	denotes	genetics
T867	665-676	_FRAGMENT	denotes	response of
T868	682-687	GO:0051716	denotes	cells
T869	677-681	UBERON_EXT:bone_element_or_tissue	denotes	bone
T870	677-687	CL:0001035	denotes	bone cells
T871	682-687	CL_GO_EXT:cell	denotes	cells
T872	703-711	CHEBI_GO_EXT:hormone	denotes	hormones
T873	738-744	GO_EXT:biological_growth_entity_or_process	denotes	growth
T874	738-752	GO_EXT:0008083	denotes	growth factors
T875	770-777	SO_EXT:0000704	denotes	genetic
T876	844-852	GO:0065007	denotes	regulate
T877	853-857	UBERON_EXT:bone_element_or_tissue	denotes	bone
T878	853-869	GO_EXT:bone_development_or_ossification	denotes	bone development
T879	940-944	UBERON_EXT:bone_element_or_tissue	denotes	bone
T880	961-965	UBERON_EXT:bone_element_or_tissue	denotes	bone
T881	961-976	GO:0045453	denotes	bone resorption
T882	996-1001	NCBITaxon_UBERON_EXT:woman	denotes	women
T883	1036-1040	UBERON_EXT:bone_element_or_tissue	denotes	bone
T884	1087-1091	UBERON_EXT:bone_element_or_tissue	denotes	bone
T885	1092-1102	CHEBI_SO_EXT:biomarker	denotes	biomarkers
T886	1210-1221	UBERON:0001132	denotes	parathyroid
T887	1210-1229	CHEBI_PR_EXT:parathyroid_hormone	denotes	parathyroid hormone
T888	1222-1229	CHEBI_GO_EXT:hormone	denotes	hormone
T889	1230-1239	CHEBI:27300	denotes	vitamin D
T890	1254-1261	UBERON:0000991	denotes	gonadal
T891	1262-1269	CHEBI_GO_EXT:hormone	denotes	hormone
T892	1290-1296	CHEBI_PR_EXT:leptin	denotes	leptin
T893	1312-1338	UBERON:0000013	denotes	sympathetic nervous system
T894	1372-1376	UBERON_EXT:bone_element_or_tissue	denotes	bone
T895	1372-1381	CL:0001035	denotes	bone cell
T896	1377-1381	CL_GO_EXT:cell	denotes	cell
T897	1377-1391	GO:0006915	denotes	cell apoptosis
T898	1398-1402	UBERON_EXT:bone_element_or_tissue	denotes	Bone
T899	1470-1481	_FRAGMENT	denotes	response of
T900	1502-1507	GO:0051716	denotes	cells
T901	1482-1501	UBERON:0007195	denotes	bone marrow stromal
T902	1482-1507	CL:0010001	denotes	bone marrow stromal cells
T903	1502-1507	CL_GO_EXT:cell	denotes	cells
T904	1546-1561	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T905	1571-1580	CL:0000136	denotes	adipocyte
T906	1605-1615	CL:0000062	denotes	osteoblast
T907	1630-1635	GO:0007568	denotes	Aging
T908	1681-1687	UBERON:0002371	denotes	marrow
T909	1688-1691	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T910	1717-1727	CL:0000136	denotes	adipocytes
T911	1744-1755	CL:0000062	denotes	osteoblasts
T912	1762-1773	CL:0000062	denotes	Osteoblasts
T913	1778-1788	CL:0000136	denotes	adipocytes
T914	1815-1826	UBERON:0003104	denotes	mesenchymal
T915	1837-1841	CL_GO_EXT:cell	denotes	cell
T916	1853-1864	UBERON:0002371	denotes	bone marrow
T917	1887-1894	GO:0065007	denotes	control
T918	1926-1936	GO:0060612	denotes	adipogenic
T919	1937-1952	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T920	1996-2011	GO_EXT:transcription	denotes	transcriptional
T921	2012-2022	GO:0065007	denotes	regulatory
T922	2023-2031	CHEBI_PR_EXT:protein	denotes	proteins
T923	2058-2062	CL_GO_EXT:cell	denotes	cell
T924	2058-2081	GO:0001709	denotes	cell fate determination
T925	2085-2096	UBERON:0002371	denotes	bone marrow
T926	2085-2114	CL:0002540	denotes	bone marrow mesenchymal cells
T927	2097-2108	UBERON:0003104	denotes	mesenchymal
T928	2109-2114	CL_GO_EXT:cell	denotes	cells
T929	2126-2136	GO:0005777	denotes	peroxisome
T930	2126-2170	PR_EXT:000013058	denotes	peroxisome proliferator–activated receptor γ
T931	2160-2168	GO_EXT:0004872	denotes	receptor
T932	2172-2177	PR_EXT:000013058	denotes	PPARγ
T933	2183-2187	PR_EXT:000009365	denotes	KLF5
T934	2209-2212	CHEBI_SO_EXT:RNA	denotes	RNA
T935	2213-2220	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T936	2221-2229	CHEBI_PR_EXT:protein	denotes	proteins
T937	2263-2266	CHEBI_SO_EXT:RNA	denotes	RNA
T938	2267-2274	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T939	2275-2283	CHEBI_PR_EXT:protein	denotes	proteins
T940	2309-2319	GO_EXT:regulator	denotes	regulators
T941	2323-2331	CL_GO_EXT:cell	denotes	cellular
T942	2323-2347	GO:0030154	denotes	cellular differentiation
T943	2362-2372	GO:0010467	denotes	expression
T944	2391-2397	SO_EXT:0000417	denotes	domain
T945	2398-2406	CHEBI_PR_EXT:protein	denotes	proteins
T946	2407-2411	PR_EXT:NOVA	denotes	NOVA
T947	2416-2420	PR_EXT:000003389	denotes	FMRP
T948	2455-2465	UBERON:0001016	denotes	neurologic
T949	2497-2498	GO:0000805	denotes	X
T950	2526-2532	NCBITaxon:9606	denotes	humans
T951	2575-2579	NCBITaxon:10088	denotes	mice
T952	2604-2611	PR_EXT:000013564	denotes	QUAKING
T953	2612-2615	CHEBI_SO_EXT:RNA	denotes	RNA
T954	2616-2623	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T955	2624-2631	CHEBI_PR_EXT:protein	denotes	protein
T956	2635-2651	CL:0000128	denotes	oligodendrocytes
T957	2656-2667	GO_EXT:myelin_assembly_or_myelination	denotes	myelination
T958	2694-2704	GO:0010467	denotes	expression
T959	2712-2715	PR_EXT:000013564	denotes	QKI
T960	2720-2728	SO_EXT:0001060	denotes	isoforms
T961	2748-2772	GO_EXT:glial_cell_development_or_generation	denotes	formation of glial cells
T962	2748-2760	_FRAGMENT	denotes	formation of
T963	2785-2792	GO_EXT:neuron_development_or_generation	denotes	neurons
T964	2761-2772	CL:0000125	denotes	glial cells
T965	2767-2772	CL_GO_EXT:cell	denotes	cells
T966	2785-2792	CL:0000540	denotes	neurons
T967	2798-2804	UBERON_EXT:neural_tissue_or_nerve_or_nervous_system	denotes	neural
T968	2843-2847	CL_GO_EXT:cell	denotes	cell
T969	2843-2866	GO:0001709	denotes	cell fate determination
T970	2885-2890	PR_EXT:Q17339	denotes	GLD-1
T971	2891-2898	CHEBI_PR_EXT:protein	denotes	protein
T972	2902-2924	NCBITaxon:6239	denotes	Caenorhabditis elegans
T973	2952-2962	CL:0000034	denotes	stem cells
T974	2957-2962	CL_GO_EXT:cell	denotes	cells
T975	2995-3001	SO_EXT:0000417	denotes	domain
T976	3002-3009	CHEBI_PR_EXT:protein	denotes	protein
T977	3010-3013	PR_EXT:O01367	denotes	HOW
T978	3017-3027	NCBITaxon:7215	denotes	Drosophila
T979	3037-3043	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T980	3044-3059	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T981	3075-3080	NCBITaxon:7147	denotes	flies
T982	3095-3100	UBERON:0000023	denotes	wings
T983	3114-3159	PR_EXT:000009279	denotes	Src substrate associated in mitosis of 68 kDa
T984	3142-3149	GO:0007067	denotes	mitosis
T985	3161-3166	PR_EXT:000009279	denotes	Sam68
T986	3205-3211	SO_EXT:0000417	denotes	domain
T987	3212-3215	CHEBI_SO_EXT:RNA	denotes	RNA
T988	3216-3223	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T989	3224-3232	CHEBI_PR_EXT:protein	denotes	proteins
T990	3252-3263	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T991	3293-3298	PR_EXT:000009279	denotes	Sam68
T992	3332-3338	SO_EXT:0000417	denotes	domain
T993	3351-3358	CHEBI_PR_EXT:protein	denotes	protein
T994	3363-3381	PR_EXT:000002997	denotes	Src family kinases
T995	3374-3381	GO_EXT:0016301	denotes	kinases
T996	3415-3426	PR_EXT:000002997	denotes	Src kinases
T997	3419-3426	GO_EXT:0016301	denotes	kinases
T998	3446-3452	UBERON:0000310	denotes	breast
T999	3446-3465	PR_EXT:000013434	denotes	breast tumor kinase
T1000	3459-3465	GO_EXT:0016301	denotes	kinase
T1001	3472-3477	PR_EXT:000009279	denotes	Sam68
T1002	3511-3517	GO_RO_EXT:biological_export	denotes	export
T1003	3523-3530	GO:0008380	denotes	spliced
T1004	3531-3534	NCBITaxon_EXT:HIV	denotes	HIV
T1005	3535-3538	CHEBI_SO_EXT:RNA	denotes	RNA
T1006	3551-3559	GO:0065007	denotes	regulate
T1007	3560-3568	SO_EXT:0000932	denotes	pre-mRNA
T1008	3564-3568	CHEBI_SO_EXT:mRNA	denotes	mRNA
T1009	3569-3579	SO_EXT:sequence_alteration_process	denotes	processing
T1010	3636-3641	PR_EXT:000009279	denotes	Sam68
T1011	3641-3642	SO_EXT:sequence_nullness_or_absence	denotes	−
T1012	3643-3644	SO_EXT:sequence_nullness_or_absence	denotes	−
T1013	3645-3649	NCBITaxon:10088	denotes	mice
T1014	3672-3680	UBERON:0004288	denotes	skeletal
T1015	3730-3735	PR_EXT:000009279	denotes	Sam68
T1016	3770-3774	UBERON_EXT:bone_element_or_tissue	denotes	bone
T1017	3783-3787	NCBITaxon:10088	denotes	mice
T1018	3802-3807	PR_EXT:000009279	denotes	Sam68
T1019	3822-3826	UBERON_EXT:bone_element_or_tissue	denotes	bone
T1020	3843-3852	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T1021	3891-3896	PR_EXT:000009279	denotes	Sam68
T1022	3897-3906	GO:0065007	denotes	regulates
T1023	3911-3929	_FRAGMENT	denotes	differentiation of
T1024	3950-3955	GO:0030154	denotes	cells
T1025	3930-3949	UBERON:0007195	denotes	bone marrow stromal
T1026	3930-3955	CL:0010001	denotes	bone marrow stromal cells
T1027	3950-3955	CL_GO_EXT:cell	denotes	cells
T1028	3972-3977	CL_GO_EXT:cell	denotes	cells
T1029	3992-3997	PR_EXT:000009279	denotes	Sam68
T1030	3997-3998	SO_EXT:sequence_nullness_or_absence	denotes	−
T1031	3999-4000	SO_EXT:sequence_nullness_or_absence	denotes	−
T1032	4001-4008	NCBITaxon:33208	denotes	animals
T1033	4022-4032	GO:0001503	denotes	osteogenic
T1034	4056-4066	GO:0060612	denotes	adipogenic
T1035	4102-4111	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T1036	4138-4143	PR_EXT:000009279	denotes	Sam68
T1037	4143-4144	SO_EXT:sequence_nullness_or_absence	denotes	−
T1038	4145-4146	SO_EXT:sequence_nullness_or_absence	denotes	−
T1039	4147-4152	NCBITaxon:10088	denotes	mouse
T1040	4153-4159	UBERON:0000922	denotes	embryo
T1041	4160-4171	CL:0000057	denotes	fibroblasts
T1042	4214-4227	GO_RO_EXT:developmental_differentiation_process	denotes	differentiate
T1043	4233-4243	CL:0000136	denotes	adipocytes
T1044	4261-4266	PR_EXT:000009279	denotes	Sam68
T1045	4275-4284	GO_EXT:regulator	denotes	regulator
T1046	4288-4299	UBERON:0002371	denotes	bone marrow
T1047	4288-4316	CL:0002540	denotes	bone marrow mesenchymal cell
T1048	4300-4311	UBERON:0003104	denotes	mesenchymal
T1049	4312-4316	CL_GO_EXT:cell	denotes	cell
T1050	4312-4332	GO:0030154	denotes	cell differentiation
T1051	4372-4378	NCBITaxon:33208	denotes	animal
T1052	4394-4398	UBERON_EXT:bone_element_or_tissue	denotes	bone
T1053	4394-4398	_FRAGMENT	denotes	bone
T1054	4411-4423	GO:1990523	denotes	regeneration
T1055	4399-4409	GO:0008152	denotes	metabolism
T1056	4443-4448	GO:0007568	denotes	aging
T2024	4960-4968	UBERON:0004288	denotes	skeleton
T2002	4460-4465	PR_EXT:000009279	denotes	Sam68
T2003	4469-4478	GO:0010467	denotes	Expressed
T2004	4497-4505	UBERON:0004288	denotes	Skeleton
T2005	4509-4518	UBERON:0000922	denotes	Embryonic
T2006	4519-4523	NCBITaxon:10088	denotes	Mice
T2007	4528-4533	PR_EXT:000009279	denotes	Sam68
T2008	4534-4538	CHEBI_SO_EXT:mRNA	denotes	mRNA
T2009	4561-4570	GO:0010467	denotes	expressed
T2010	4600-4607	CHEBI_PR_EXT:protein	denotes	protein
T2011	4608-4618	GO:0010467	denotes	expression
T2012	4680-4689	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T2013	4706-4715	UBERON:0000922	denotes	embryonic
T2014	4716-4720	NCBITaxon:10088	denotes	mice
T2015	4777-4782	PR_EXT:000009279	denotes	Sam68
T2016	4783-4791	GO:0042571	denotes	antibody
T2017	4803-4810	NCBITaxon:9986	denotes	rabbits
T2018	4833-4840	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T2019	4861-4872	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T2020	4891-4896	NCBITaxon:10088	denotes	mouse
T2021	4897-4902	PR_EXT:000009279	denotes	Sam68
T2022	4903-4910	CHEBI_PR_EXT:protein	denotes	protein
T2023	4917-4922	PR_EXT:000009279	denotes	Sam68
T2025	4978-4985	UBERON:0000479	denotes	tissues
T2026	5000-5009	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T2027	5010-5014	NCBITaxon:10088	denotes	mice
T2028	5079-5095	GO:0005634	denotes	nucleus of cells
T2029	5090-5095	CL_GO_EXT:cell	denotes	cells
T2030	5114-5119	UBERON:0000955	denotes	brain
T2031	5121-5126	UBERON:0000948	denotes	heart
T2032	5132-5147	UBERON:0002108	denotes	small intestine
T2033	5175-5187	CL:0000138	denotes	chondrocytes
T2034	5195-5207	UBERON:0001706	denotes	nasal septum
T2035	5216-5225	UBERON:0002530	denotes	glandular
T2036	5226-5232	UBERON:0000479	denotes	tissue
T2037	5249-5264	UBERON:0001823	denotes	nasal cartilage
T2038	5297-5305	UBERON:0002412	denotes	vertebra
T2039	5310-5330	UBERON:0001066	denotes	intervertebral discs
T2040	5355-5364	_FRAGMENT	denotes	epiphysis
T2041	5403-5416	UBERON:0001437	denotes	of long bones
T2042	5382-5392	_FRAGMENT	denotes	metaphysis
T2043	5403-5416	UBERON:0001438	denotes	of long bones
T2044	5418-5425	GO:0005634	denotes	Nuclear
T2045	5451-5464	GO:0008283	denotes	proliferating
T2046	5465-5477	CL:0000138	denotes	chondrocytes
T2047	5482-5507	CL:0000743	denotes	hypertrophic chondrocytes
T2048	5533-5544	CL:0000062	denotes	osteoblasts
T2049	5575-5586	CL:0000092	denotes	osteoclasts
T2050	5641-5646	UBERON:0001977	denotes	serum
T2051	5663-5668	UBERON:0001977	denotes	serum
T2052	5705-5712	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T2053	5790-5795	PR_EXT:000009279	denotes	Sam68
T2054	5796-5803	CHEBI_PR_EXT:protein	denotes	protein
T2055	5819-5828	GO:0010467	denotes	expressed
T2056	5847-5852	NCBITaxon:10088	denotes	mouse
T2057	5853-5859	UBERON:0000922	denotes	embryo
T2058	5888-5898	GO:0010467	denotes	expression
T2059	5902-5911	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T2060	5916-5920	UBERON_EXT:bone_element_or_tissue	denotes	bone
T2446	7122-7127	PR_EXT:000009279	denotes	Sam68
T2447	7149-7154	NCBITaxon:10088	denotes	Mouse
T2448	7181-7192	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T2449	7201-7206	PR_EXT:000009279	denotes	Sam68
T2450	7221-7226	PR_EXT:000009279	denotes	Sam68
T2451	7237-7241	NCBITaxon:10088	denotes	mice
T2452	7268-7273	SO_EXT:0000147	denotes	exons
T2453	7289-7294	PR_EXT:000009279	denotes	sam68
T2454	7295-7299	SO_EXT:0000704	denotes	gene
T2455	7307-7313	SO_EXT:sequence_coding_function	denotes	encode
T2456	7351-7354	CHEBI_SO_EXT:RNA	denotes	RNA
T2457	7355-7362	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T2458	7363-7369	SO_EXT:0000417	denotes	domain
T2459	7413-7419	SO_EXT:0001023	denotes	allele
T2460	7485-7496	SO_EXT:genomic_DNA	denotes	genomic DNA
T2461	7493-7496	CHEBI_SO_EXT:DNA	denotes	DNA
T2462	7517-7522	PR_EXT:000009279	denotes	Sam68
T2463	7523-7534	SO_EXT:0000673	denotes	transcripts
T2464	7535-7542	SO_EXT:sequence_coding_function	denotes	encoded
T2465	7546-7551	SO_EXT:0000147	denotes	exons
T2466	7587-7589	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T2467	7612-7617	PR_EXT:000009279	denotes	Sam68
T2468	7617-7618	SO_EXT:sequence_nullness_or_absence	denotes	−
T2469	7619-7620	SO_EXT:sequence_nullness_or_absence	denotes	−
T2470	7621-7625	NCBITaxon:10088	denotes	mice
T2471	7641-7646	PR_EXT:000009279	denotes	Sam68
T2472	7647-7654	CHEBI_PR_EXT:protein	denotes	protein
T2473	7698-7703	PR_EXT:000009279	denotes	Sam68
T2474	7719-7729	GO:0042571	denotes	antibodies
T2475	7748-7754	NCBITaxon:9986	denotes	rabbit
T2476	7755-7760	UBERON:0001977	denotes	serum
T2477	7769-7774	PR_EXT:000009279	denotes	Sam68
T2478	7796-7803	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T2479	7829-7835	NCBITaxon:9986	denotes	rabbit
T2480	7841-7846	PR_EXT:000009279	denotes	Sam68
T2481	7847-7855	GO:0042571	denotes	antibody
T2482	7884-7894	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T2483	7898-7909	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T2484	7913-7918	PR_EXT:000009279	denotes	Sam68
T2485	7966-7971	NCBITaxon:10088	denotes	mouse
T2486	7985-7990	PR_EXT:000009279	denotes	Sam68
T2487	7996-8005	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T2488	8155-8160	PR_EXT:000009279	denotes	Sam68
T2489	8160-8161	SO_EXT:sequence_nullness_or_absence	denotes	−
T2490	8162-8163	SO_EXT:sequence_nullness_or_absence	denotes	−
T2491	8164-8168	NCBITaxon_UBERON_EXT:pup	denotes	pups
T2492	8169-8173	GO:0016265	denotes	died
T2493	8177-8182	GO:0007567	denotes	birth
T2494	8202-8207	PR_EXT:000009279	denotes	Sam68
T2495	8207-8208	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2496	8209-8210	SO_EXT:sequence_nullness_or_absence	denotes	-
T2497	8211-8215	NCBITaxon:10088	denotes	mice
T2498	8247-8252	PR_EXT:000009279	denotes	Sam68
T2499	8252-8253	SO_EXT:sequence_nullness_or_absence	denotes	−
T2500	8254-8255	SO_EXT:sequence_nullness_or_absence	denotes	−
T2501	8256-8260	NCBITaxon_UBERON_EXT:pup	denotes	pups
T2502	8279-8295	UBERON:0012101	denotes	perinatal period
T2503	8283-8288	GO:0007567	denotes	natal
T2504	8347-8352	PR_EXT:000009279	denotes	Sam68
T2505	8353-8357	CHEBI_SO_EXT:mRNA	denotes	mRNA
T2506	8368-8377	GO:0010467	denotes	expressed
T2507	8382-8396	GO_PATO_EXT:phosphorylation_process_or_quality	denotes	phosphorylated
T2508	8400-8407	GO:0007067	denotes	mitosis
T2509	8421-8426	PR_EXT:000009279	denotes	Sam68
T2510	8426-8427	SO_EXT:sequence_nullness_or_absence	denotes	−
T2511	8428-8429	SO_EXT:sequence_nullness_or_absence	denotes	−
T2512	8430-8434	NCBITaxon:10088	denotes	mice
T2513	8510-8515	PR_EXT:000009279	denotes	Sam68
T2514	8515-8516	SO_EXT:sequence_nullness_or_absence	denotes	−
T2515	8517-8518	SO_EXT:sequence_nullness_or_absence	denotes	−
T2516	8519-8523	NCBITaxon:10088	denotes	mice
T2517	8554-8562	GO_EXT:breeding	denotes	breeding
T2518	8570-8574	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T2519	8595-8602	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T2932	9877-9882	PR_EXT:000009279	denotes	Sam68
T2933	9903-9907	NCBITaxon:10088	denotes	Mice
T2934	9925-9929	UBERON_EXT:bone_element_or_tissue	denotes	Bone
T2935	9935-9938	PR_EXT:000027234	denotes	Src
T2936	9939-9943	SO_EXT:sequence_nullness	denotes	null
T2937	9944-9951	NCBITaxon:33208	denotes	animals
T2938	9970-9974	UBERON_EXT:bone_element_or_tissue	denotes	bone
T2939	9975-9985	GO:0008152	denotes	metabolism
T2940	10010-10015	PR_EXT:000009279	denotes	Sam68
T2941	10034-10037	PR_EXT:000027234	denotes	Src
T2942	10065-10070	PR_EXT:000009279	denotes	Sam68
T2943	10071-10075	NCBITaxon:10088	denotes	mice
T2944	10080-10088	UBERON:0004288	denotes	skeletal
T2945	10115-10120	PR_EXT:000009279	denotes	Sam68
T2946	10120-10121	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2947	10122-10123	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2948	10128-10133	PR_EXT:000009279	denotes	Sam68
T2949	10133-10134	SO_EXT:sequence_nullness_or_absence	denotes	−
T2950	10135-10136	SO_EXT:sequence_nullness_or_absence	denotes	−
T2951	10137-10141	NCBITaxon:10088	denotes	mice
T2952	10188-10196	UBERON:0004288	denotes	skeletal
T2953	10241-10245	UBERON_EXT:bone_element_or_tissue	denotes	bone
T2954	10340-10346	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T2955	10347-10351	NCBITaxon:10088	denotes	mice
T2956	10376-10382	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T2957	10383-10387	NCBITaxon:10088	denotes	mice
T2958	10422-10426	UBERON_EXT:body	denotes	body
T2959	10456-10461	PR_EXT:000009279	denotes	Sam68
T2960	10461-10462	SO_EXT:sequence_nullness_or_absence	denotes	−
T2961	10463-10464	SO_EXT:sequence_nullness_or_absence	denotes	−
T2962	10465-10469	NCBITaxon:10088	denotes	mice
T2963	10488-10493	PR_EXT:000009279	denotes	Sam68
T2964	10493-10494	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2965	10495-10496	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2966	10497-10501	NCBITaxon:10088	denotes	mice
T2967	10526-10530	UBERON_EXT:bone_element_or_tissue	denotes	bone
T2968	10546-10551	_FRAGMENT	denotes	axial
T2969	10569-10577	UBERON:0011137	denotes	skeleton
T2970	10556-10577	UBERON:0002091	denotes	appendicular skeleton
T2971	10785-10793	UBERON:0001851	denotes	cortical
T2972	10830-10841	UBERON:0001438	denotes	metaphyseal
T2973	10842-10846	UBERON_EXT:bone_element_or_tissue	denotes	bone
T2974	10872-10878	UBERON:0000981	denotes	femora
T2975	10895-10900	PR_EXT:000009279	denotes	Sam68
T2976	10900-10901	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2977	10902-10903	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2978	10904-10908	NCBITaxon:10088	denotes	mice
T2979	10935-10939	NCBITaxon:10088	denotes	mice
T2980	10950-10958	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T2981	10976-10981	PR_EXT:000009279	denotes	Sam68
T2982	10981-10982	SO_EXT:sequence_nullness_or_absence	denotes	−
T2983	10983-10984	SO_EXT:sequence_nullness_or_absence	denotes	−
T2984	10985-10989	NCBITaxon:10088	denotes	mice
T2985	11013-11028	UBERON:0002483	denotes	trabecular bone
T2986	11072-11094	UBERON:0004621	denotes	fifth lumbar vertebrae
T2987	11115-11120	PR_EXT:000009279	denotes	Sam68
T2988	11120-11121	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2989	11122-11123	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2990	11124-11128	NCBITaxon:10088	denotes	mice
T2991	11144-11149	PR_EXT:000009279	denotes	Sam68
T2992	11149-11150	SO_EXT:sequence_nullness_or_absence	denotes	−
T2993	11151-11152	SO_EXT:sequence_nullness_or_absence	denotes	−
T2994	11153-11157	NCBITaxon:10088	denotes	mice
T2995	11184-11188	UBERON_EXT:body	denotes	body
T2996	11189-11193	UBERON_EXT:bone_element_or_tissue	denotes	bone
T2997	11194-11201	CHEBI:46662	denotes	mineral
T2998	11249-11254	NCBITaxon:10088	denotes	mouse
T2999	11333-11338	PR_EXT:000009279	denotes	Sam68
T3000	11338-11339	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3001	11340-11341	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3002	11346-11351	PR_EXT:000009279	denotes	Sam68
T3003	11351-11352	SO_EXT:sequence_nullness_or_absence	denotes	−
T3004	11353-11354	SO_EXT:sequence_nullness_or_absence	denotes	−
T3005	11355-11359	NCBITaxon:10088	denotes	mice
T3006	11436-11441	PR_EXT:000009279	denotes	Sam68
T3007	11441-11442	SO_EXT:sequence_nullness_or_absence	denotes	−
T3008	11443-11444	SO_EXT:sequence_nullness_or_absence	denotes	−
T3009	11445-11449	NCBITaxon:10088	denotes	mice
T3010	11514-11519	UBERON:0000981	denotes	femur
T3011	11524-11532	UBERON:0002412	denotes	vertebra
T3012	11540-11545	PR_EXT:000009279	denotes	Sam68
T3013	11545-11546	SO_EXT:sequence_nullness_or_absence	denotes	−
T3014	11547-11548	SO_EXT:sequence_nullness_or_absence	denotes	−
T3015	11549-11553	NCBITaxon:10088	denotes	mice
T3016	11555-11559	UBERON_EXT:bone_element_or_tissue	denotes	Bone
T3017	11560-11567	CHEBI:46662	denotes	mineral
T3018	11620-11629	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T3019	11630-11634	NCBITaxon:10088	denotes	mice
T3020	11676-11680	UBERON_EXT:body	denotes	body
T3021	11692-11699	UBERON:0000981	denotes	femoral
T3022	11704-11713	UBERON:0002412	denotes	vertebral
T3023	11741-11746	PR_EXT:000009279	denotes	Sam68
T3024	11746-11747	SO_EXT:sequence_nullness_or_absence	denotes	−
T3025	11748-11749	SO_EXT:sequence_nullness_or_absence	denotes	−
T3026	11784-11789	PR_EXT:000009279	denotes	Sam68
T3027	11789-11790	SO_EXT:sequence_nullness_or_absence	denotes	−
T3028	11791-11792	SO_EXT:sequence_nullness_or_absence	denotes	−
T3029	11793-11797	NCBITaxon:10088	denotes	mice
T3030	11829-11833	UBERON_EXT:bone_element_or_tissue	denotes	bone
T3031	11841-11846	_FRAGMENT	denotes	axial
T3032	11864-11872	UBERON:0011137	denotes	skeleton
T3033	11851-11872	UBERON:0002091	denotes	appendicular skeleton
T3034	12007-12011	UBERON_EXT:bone_element_or_tissue	denotes	bone
T3548	13366-13370	UBERON_EXT:bone_element_or_tissue	denotes	Bone
T3549	13387-13391	GO_PATO_EXT:aging_or_agedness	denotes	Aged
T3550	13392-13397	PR_EXT:000009279	denotes	Sam68
T3551	13397-13398	SO_EXT:sequence_nullness_or_absence	denotes	−
T3552	13399-13400	SO_EXT:sequence_nullness_or_absence	denotes	−
T3553	13401-13405	NCBITaxon:10088	denotes	Mice
T3554	13406-13410	UBERON_EXT:bone_element_or_tissue	denotes	Bone
T3555	13480-13489	UBERON:0004288	denotes	skeletons
T3556	13493-13497	GO_PATO_EXT:aging_or_agedness	denotes	aged
T3557	13506-13510	NCBITaxon:10088	denotes	mice
T3558	13561-13565	UBERON_EXT:bone_element_or_tissue	denotes	bone
T3559	13574-13580	NCBITaxon:9606	denotes	humans
T3560	13604-13614	NCBITaxon:1	denotes	individual
T3561	13710-13714	UBERON_EXT:bone_element_or_tissue	denotes	bone
T3562	13736-13742	UBERON:0000479	denotes	tissue
T3563	13795-13800	PR_EXT:000009279	denotes	Sam68
T3564	13800-13801	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3565	13802-13803	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3566	13804-13808	NCBITaxon:10088	denotes	mice
T3567	13850-13854	NCBITaxon:10088	denotes	mice
T3568	13863-13872	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T3569	13903-13908	PR_EXT:000009279	denotes	Sam68
T3570	13908-13909	SO_EXT:sequence_nullness_or_absence	denotes	−
T3571	13910-13911	SO_EXT:sequence_nullness_or_absence	denotes	−
T3572	13912-13916	NCBITaxon:10088	denotes	mice
T3573	14167-14177	PATO_UBERON_EXT:trabeculation_entity_or_quality	denotes	trabecular
T3574	14232-14237	PR_EXT:000009279	denotes	Sam68
T3575	14237-14238	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3576	14239-14240	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3577	14241-14245	NCBITaxon:10088	denotes	mice
T3578	14366-14376	PATO_UBERON_EXT:trabeculation_entity_or_quality	denotes	Trabecular
T3579	14435-14439	NCBITaxon:10088	denotes	mice
T3580	14504-14514	UBERON:0000440	denotes	trabeculae
T3581	14555-14565	UBERON:0000440	denotes	trabeculae
T3582	14587-14592	PR_EXT:000009279	denotes	Sam68
T3583	14592-14593	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3584	14594-14595	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3585	14596-14600	NCBITaxon:10088	denotes	mice
T3586	14642-14646	NCBITaxon:10088	denotes	mice
T4029	15537-15541	UBERON_EXT:bone_element_or_tissue	denotes	Bone
T4030	15537-15552	GO:0046849	denotes	Bone Remodeling
T4031	15569-15573	GO_PATO_EXT:aging_or_agedness	denotes	Aged
T4032	15574-15579	PR_EXT:000009279	denotes	Sam68
T4033	15579-15580	SO_EXT:sequence_nullness_or_absence	denotes	−
T4034	15581-15582	SO_EXT:sequence_nullness_or_absence	denotes	−
T4035	15583-15587	NCBITaxon:10088	denotes	Mice
T4036	15653-15657	UBERON_EXT:bone_element_or_tissue	denotes	bone
T4037	15666-15670	GO_PATO_EXT:aging_or_agedness	denotes	aged
T4038	15671-15676	PR_EXT:000009279	denotes	Sam68
T4039	15676-15677	SO_EXT:sequence_nullness_or_absence	denotes	−
T4040	15678-15679	SO_EXT:sequence_nullness_or_absence	denotes	−
T4041	15680-15684	NCBITaxon:10088	denotes	mice
T4042	15729-15735	UBERON:0000981	denotes	femora
T4043	15740-15745	UBERON:0000979	denotes	tibia
T4044	15758-15768	CL:0000062	denotes	osteoblast
T4045	15773-15783	CL:0000092	denotes	osteoclast
T4046	15813-15819	CHEBI_GO_SO_EXT:enzyme	denotes	enzyme
T4047	15847-15867	GO_PR_EXT:alkaline_phosphatase	denotes	alkaline phosphatase
T4048	15869-15872	GO_PR_EXT:alkaline_phosphatase	denotes	ALP
T4049	15910-15919	CHEBI_SO_EXT:biomarker	denotes	biomarker
T4050	15924-15935	CL:0000062	denotes	osteoblasts
T4051	15940-15948	CHEBI_EXT:tartrate	denotes	tartrate
T4052	15940-15962	PR_EXT:000001937	denotes	tartrate-resistant ALP
T4053	15959-15962	GO_PR_EXT:alkaline_phosphatase	denotes	ALP
T4054	15964-15972	CHEBI_EXT:tartrate	denotes	tartrate
T4055	15964-15999	PR_EXT:000001937	denotes	tartrate-resistant acid phosphatase
T4056	15983-15987	CHEBI_EXT:37527	denotes	acid
T4057	15983-15999	GO_EXT:0003993	denotes	acid phosphatase
T4058	16001-16005	PR_EXT:000001937	denotes	TRAP
T4059	16033-16039	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T4060	16044-16055	CL:0000092	denotes	osteoclasts
T4061	16092-16097	PR_EXT:000009279	denotes	Sam68
T4062	16097-16098	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4063	16099-16100	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4064	16124-16129	PR_EXT:000009279	denotes	Sam68
T4065	16129-16130	SO_EXT:sequence_nullness_or_absence	denotes	−
T4066	16131-16132	SO_EXT:sequence_nullness_or_absence	denotes	−
T4067	16152-16156	NCBITaxon:10088	denotes	mice
T4068	16177-16180	GO_PR_EXT:alkaline_phosphatase	denotes	ALP
T4069	16186-16190	PR_EXT:000001937	denotes	TRAP
T4070	16200-16205	CL_GO_EXT:cell	denotes	cells
T4071	16239-16244	PR_EXT:000009279	denotes	Sam68
T4072	16244-16245	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4073	16246-16247	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4074	16248-16252	NCBITaxon:10088	denotes	mice
T4075	16311-16316	PR_EXT:000009279	denotes	Sam68
T4076	16316-16317	SO_EXT:sequence_nullness_or_absence	denotes	−
T4077	16318-16319	SO_EXT:sequence_nullness_or_absence	denotes	−
T4078	16320-16324	NCBITaxon:10088	denotes	mice
T4079	16367-16377	CL:0000062	denotes	osteoblast
T4080	16382-16392	CL:0000092	denotes	osteoclast
T4081	16422-16427	PR_EXT:000009279	denotes	Sam68
T4082	16427-16428	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4083	16429-16430	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4084	16431-16435	NCBITaxon:10088	denotes	mice
T4085	16451-16455	UBERON_EXT:bone_element_or_tissue	denotes	bone
T4086	16507-16517	CL:0000092	denotes	osteoclast
T4087	16523-16533	CL:0000062	denotes	osteoblast
T4088	17253-17263	UBERON:0002495	denotes	long bones
T4089	17326-17330	UBERON_EXT:bone_element_or_tissue	denotes	bone
T4090	17337-17341	UBERON_EXT:bone_element_or_tissue	denotes	Bone
T4091	17371-17378	UBERON:0008883	denotes	osteoid
T4092	17392-17399	CHEBI:46662	denotes	mineral
T4093	17469-17474	PR_EXT:000009279	denotes	Sam68
T4094	17474-17475	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4095	17476-17477	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4096	17478-17482	NCBITaxon:10088	denotes	mice
T4097	17509-17514	PR_EXT:000009279	denotes	Sam68
T4098	17514-17515	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4099	17516-17517	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4100	17518-17522	NCBITaxon:10088	denotes	mice
T4101	17588-17594	UBERON:0002371	denotes	marrow
T4102	17595-17598	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T4103	17632-17643	CL:0000062	denotes	osteoblasts
T4104	17657-17668	CL:0000092	denotes	osteoclasts
T4105	17682-17688	UBERON:0000479	denotes	tissue
T4106	17767-17772	PR_EXT:000009279	denotes	Sam68
T4107	17772-17773	SO_EXT:sequence_nullness_or_absence	denotes	−
T4108	17774-17775	SO_EXT:sequence_nullness_or_absence	denotes	−
T4109	17776-17780	NCBITaxon:10088	denotes	mice
T4110	17834-17840	UBERON:0002371	denotes	marrow
T4111	17841-17844	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T4112	17871-17875	NCBITaxon:10088	denotes	mice
T4113	17886-17894	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T4114	17911-17916	CL_GO_EXT:cell	denotes	cells
T4115	17953-17957	UBERON_EXT:bone_element_or_tissue	denotes	bone
T4116	18041-18052	CL:0000062	denotes	osteoblasts
T4117	18056-18067	CL:0000092	denotes	osteoclasts
T4118	18097-18101	NCBITaxon:10088	denotes	mice
T4119	18215-18220	UBERON:0001977	denotes	serum
T4120	18221-18222	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C
T4121	18284-18287	GO_PR_EXT:alkaline_phosphatase	denotes	ALP
T4122	18375-18380	PR_EXT:000009279	denotes	Sam68
T4123	18380-18381	SO_EXT:sequence_nullness_or_absence	denotes	−
T4124	18382-18383	SO_EXT:sequence_nullness_or_absence	denotes	−
T4125	18384-18388	NCBITaxon:10088	denotes	mice
T4126	18407-18412	UBERON:0001977	denotes	Serum
T4127	18413-18421	CHEBI_EXT:50114	denotes	estrogen
T4128	18470-18474	NCBITaxon:10088	denotes	mice
T4129	18489-18497	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T4130	18528-18541	PR_EXT:000001393	denotes	interleukin-6
T4131	18588-18594	CHEBI_PR_EXT:leptin	denotes	leptin
T4132	18598-18608	GO:0065007	denotes	regulating
T4133	18609-18613	UBERON_EXT:body	denotes	body
T4134	18618-18622	UBERON_EXT:bone_element_or_tissue	denotes	bone
T4135	18629-18634	UBERON:0001977	denotes	serum
T4136	18635-18641	CHEBI_PR_EXT:leptin	denotes	leptin
T4137	18658-18663	PR_EXT:000009279	denotes	Sam68
T4138	18663-18664	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4139	18665-18666	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4140	18671-18676	PR_EXT:000009279	denotes	Sam68
T4141	18676-18677	SO_EXT:sequence_nullness_or_absence	denotes	−
T4142	18678-18679	SO_EXT:sequence_nullness_or_absence	denotes	−
T4143	18680-18684	NCBITaxon:10088	denotes	mice
T4144	18703-18708	PR_EXT:000009279	denotes	Sam68
T4145	18708-18709	SO_EXT:sequence_nullness_or_absence	denotes	−
T4146	18710-18711	SO_EXT:sequence_nullness_or_absence	denotes	−
T4147	18712-18716	NCBITaxon:10088	denotes	mice
T4148	18767-18772	PR_EXT:000009279	denotes	Sam68
T4149	18772-18773	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4150	18774-18775	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4151	18776-18780	NCBITaxon:10088	denotes	mice
T4152	18791-18796	PR_EXT:000009279	denotes	Sam68
T4153	18796-18797	SO_EXT:sequence_nullness_or_absence	denotes	−
T4154	18798-18799	SO_EXT:sequence_nullness_or_absence	denotes	−
T4155	18800-18804	NCBITaxon:10088	denotes	mice
T4156	18885-18889	UBERON_EXT:bone_element_or_tissue	denotes	bone
T4157	18902-18907	PR_EXT:000009279	denotes	Sam68
T4158	18907-18908	SO_EXT:sequence_nullness_or_absence	denotes	−
T4159	18909-18910	SO_EXT:sequence_nullness_or_absence	denotes	−
T4160	18911-18915	NCBITaxon:10088	denotes	mice
T4161	18949-18957	CHEBI_EXT:50114	denotes	estrogen
T4162	19026-19032	CHEBI_PR_EXT:leptin	denotes	leptin
T4878	19042-19052	CL:0000062	denotes	Osteoblast
T4879	19062-19072	CL:0000092	denotes	Osteoclast
T4880	19097-19102	PR_EXT:000009279	denotes	Sam68
T4881	19102-19103	SO_EXT:sequence_nullness_or_absence	denotes	−
T4882	19104-19105	SO_EXT:sequence_nullness_or_absence	denotes	−
T4883	19106-19110	NCBITaxon:10088	denotes	Mice
T4884	19134-19138	UBERON_EXT:bone_element_or_tissue	denotes	bone
T4885	19155-19160	UBERON:0007023	denotes	adult
T4886	19210-19220	CL:0000062	denotes	osteoblast
T4887	19224-19234	CL:0000092	denotes	osteoclast
T4888	19287-19291	UBERON_EXT:bone_element_or_tissue	denotes	bone
T4889	19346-19351	PR_EXT:000009279	denotes	Sam68
T4890	19351-19352	SO_EXT:sequence_nullness_or_absence	denotes	−
T4891	19353-19354	SO_EXT:sequence_nullness_or_absence	denotes	−
T4892	19355-19359	NCBITaxon:10088	denotes	mice
T4893	19376-19380	UBERON_EXT:bone_element_or_tissue	denotes	bone
T4894	19434-19439	PR_EXT:000009279	denotes	Sam68
T4895	19439-19440	SO_EXT:sequence_nullness_or_absence	denotes	−
T4896	19441-19442	SO_EXT:sequence_nullness_or_absence	denotes	−
T4897	19443-19454	CL:0000062	denotes	osteoblasts
T4898	19459-19470	CL:0000092	denotes	osteoclasts
T4899	19511-19530	UBERON:0007195	denotes	bone marrow stromal
T4900	19511-19536	CL:0010001	denotes	bone marrow stromal cells
T4901	19531-19536	CL_GO_EXT:cell	denotes	cells
T4902	19563-19568	PR_EXT:000009279	denotes	Sam68
T4903	19568-19569	SO_EXT:sequence_nullness_or_absence	denotes	−
T4904	19570-19571	SO_EXT:sequence_nullness_or_absence	denotes	−
T4905	19572-19576	NCBITaxon:10088	denotes	mice
T4906	19607-19617	CL:0000062	denotes	osteoblast
T4907	19618-19633	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T4908	19680-19683	GO_PR_EXT:alkaline_phosphatase	denotes	ALP
T4909	19788-19793	PR_EXT:000009279	denotes	Sam68
T4910	19793-19794	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4911	19795-19796	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4912	19797-19801	NCBITaxon:10088	denotes	mice
T4913	19834-19844	CL:0000057	denotes	fibroblast
T4914	19871-19872	CL:0000057	denotes	F
T4915	19922-19924	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T4916	19941-19950	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T4917	19951-19958	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T4918	19962-19972	CL:0000062	denotes	osteoblast
T4919	19973-19988	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T4920	20042-20045	CHEBI_SO_EXT:RNA	denotes	RNA
T4921	20051-20056	PR_EXT:000009279	denotes	Sam68
T4922	20056-20057	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4923	20058-20059	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4924	20064-20069	PR_EXT:000009279	denotes	Sam68
T4925	20069-20070	SO_EXT:sequence_nullness_or_absence	denotes	−
T4926	20071-20072	SO_EXT:sequence_nullness_or_absence	denotes	−
T4927	20073-20077	NCBITaxon:10088	denotes	mice
T4928	20088-20103	PR_EXT:000003263	denotes	type I collagen
T4929	20095-20103	CHEBI_PR_EXT:collagen	denotes	collagen
T4930	20119-20131	GO_EXT:positive_regulation	denotes	up-regulated
T4931	20158-20163	PR_EXT:000009279	denotes	Sam68
T4932	20163-20164	SO_EXT:sequence_nullness_or_absence	denotes	−
T4933	20165-20166	SO_EXT:sequence_nullness_or_absence	denotes	−
T4934	20167-20171	NCBITaxon:10088	denotes	mice
T4935	20203-20214	CL:0000092	denotes	osteoclasts
T4936	20215-20223	GO_EXT:biological_release	denotes	released
T4937	20241-20251	UBERON:0002495	denotes	long bones
T4938	20255-20260	PR_EXT:000009279	denotes	Sam68
T4939	20260-20261	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4940	20262-20263	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4941	20268-20273	PR_EXT:000009279	denotes	Sam68
T4942	20273-20274	SO_EXT:sequence_nullness_or_absence	denotes	−
T4943	20275-20276	SO_EXT:sequence_nullness_or_absence	denotes	−
T4944	20277-20281	NCBITaxon:10088	denotes	mice
T4945	20307-20311	PR_EXT:000001937	denotes	TRAP
T4946	20379-20385	UBERON:0001751	denotes	dentin
T4947	20420-20428	CHEBI:10545	denotes	electron
T4948	20485-20496	CL:0000092	denotes	osteoclasts
T4949	20530-20535	PR_EXT:000009279	denotes	Sam68
T4950	20535-20536	SO_EXT:sequence_nullness_or_absence	denotes	−
T4951	20537-20538	SO_EXT:sequence_nullness_or_absence	denotes	−
T4952	20539-20543	NCBITaxon:10088	denotes	mice
T4953	20560-20563	PR_EXT:000027234	denotes	Src
T4954	20564-20568	SO_EXT:sequence_nullness	denotes	null
T4955	20569-20573	NCBITaxon:10088	denotes	mice
T5514	21660-21665	PR_EXT:000009279	denotes	Sam68
T5515	21675-21684	CL:0000136	denotes	Adipocyte
T5516	21685-21700	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T5517	21714-21724	CL:0000062	denotes	Osteoblast
T5518	21725-21740	GO_RO_EXT:developmental_differentiation_process	denotes	Differentiation
T5519	21768-21787	UBERON:0007195	denotes	bone marrow stromal
T5520	21768-21793	CL:0010001	denotes	bone marrow stromal cells
T5521	21788-21793	CL_GO_EXT:cell	denotes	cells
T5522	21812-21823	CL:0000062	denotes	osteoblasts
T5523	21828-21838	CL:0000136	denotes	adipocytes
T5524	21860-21864	UBERON_EXT:bone_element_or_tissue	denotes	bone
T5525	21903-21918	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T5526	21928-21937	CL:0000136	denotes	adipocyte
T5527	21975-21980	PR_EXT:000009279	denotes	Sam68
T5528	22001-22020	UBERON:0007195	denotes	bone marrow stromal
T5529	22001-22026	CL:0010001	denotes	bone marrow stromal cells
T5530	22021-22026	CL_GO_EXT:cell	denotes	cells
T5531	22030-22043	GO_RO_EXT:developmental_differentiation_process	denotes	differentiate
T5532	22054-22064	GO:0001503	denotes	osteogenic
T5533	22076-22086	GO:0060612	denotes	adipogenic
T5534	22123-22128	PR_EXT:000009279	denotes	Sam68
T5535	22146-22154	GO:0065007	denotes	regulate
T5536	22155-22159	UBERON_EXT:bone_element_or_tissue	denotes	bone
T5537	22208-22215	GO:0065007	denotes	control
T5538	22234-22240	CHEBI_PR_EXT:leptin	denotes	leptin
T5539	22249-22275	UBERON:0000013	denotes	sympathetic nervous system
T5540	22295-22314	GO_EXT:negative_regulation	denotes	negatively regulate
T5541	22315-22319	UBERON_EXT:bone_element_or_tissue	denotes	bone
T5542	22352-22357	PR_EXT:000009279	denotes	Sam68
T5543	22365-22378	_FRAGMENT	denotes	regulation of
T5544	22389-22404	GO:0045595	denotes	differentiation
T5545	22379-22388	CL:0000136	denotes	adipocyte
T5546	22449-22454	PR_EXT:000009279	denotes	Sam68
T5547	22454-22455	SO_EXT:normal_or_wild_type_or_present	denotes	+
T5548	22456-22457	SO_EXT:normal_or_wild_type_or_present	denotes	+
T5549	22462-22467	PR_EXT:000009279	denotes	Sam68
T5550	22467-22468	SO_EXT:sequence_nullness_or_absence	denotes	−
T5551	22469-22470	SO_EXT:sequence_nullness_or_absence	denotes	−
T5552	22471-22478	UBERON:0000922	denotes	embryos
T5553	22492-22497	PR_EXT:000009279	denotes	Sam68
T5554	22497-22498	SO_EXT:sequence_nullness_or_absence	denotes	−
T5555	22499-22500	SO_EXT:sequence_nullness_or_absence	denotes	−
T5556	22511-22525	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T5557	22531-22541	CL:0000136	denotes	adipocytes
T5558	22585-22597	CHEBI:8228	denotes	pioglitazone
T5559	22608-22620	GO:0060612	denotes	adipogenesis
T5560	22622-22627	CL_GO_EXT:cell	denotes	Cells
T5561	22691-22703	GO:0060612	denotes	adipogenesis
T5562	22705-22717	GO:0060612	denotes	Adipogenesis
T5563	22745-22754	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T5564	22781-22786	PR_EXT:000009279	denotes	Sam68
T5565	22786-22787	SO_EXT:sequence_nullness_or_absence	denotes	−
T5566	22788-22789	SO_EXT:sequence_nullness_or_absence	denotes	−
T5567	22844-22849	PR_EXT:000009279	denotes	Sam68
T5568	22853-22862	CL:0000136	denotes	adipocyte
T5569	22863-22878	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T5570	22895-22905	GO:0010467	denotes	expression
T5571	22913-22926	GO_EXT:transcription	denotes	transcription
T5572	22913-22934	GO_EXT:transcription_factor	denotes	transcription factors
T5573	22949-22954	PR_EXT:000013058	denotes	PPARγ
T5574	22959-22963	PR_EXT:000009365	denotes	KLF5
T5575	22980-22985	PR_EXT:000009279	denotes	Sam68
T5576	22985-22986	SO_EXT:sequence_nullness_or_absence	denotes	−
T5577	22987-22988	SO_EXT:sequence_nullness_or_absence	denotes	−
T5578	22989-23003	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T5579	23023-23028	PR_EXT:000009279	denotes	Sam68
T5580	23028-23029	SO_EXT:normal_or_wild_type_or_present	denotes	+
T5581	23030-23031	SO_EXT:normal_or_wild_type_or_present	denotes	+
T5582	23063-23075	GO:0060612	denotes	adipogenesis
T5583	23094-23099	PR_EXT:000009279	denotes	Sam68
T5584	23174-23179	PR_EXT:000009279	denotes	Sam68
T5585	23179-23180	SO_EXT:sequence_nullness_or_absence	denotes	−
T5586	23181-23182	SO_EXT:sequence_nullness_or_absence	denotes	−
T5587	23183-23187	NCBITaxon:10088	denotes	mice
T5588	23262-23267	PR_EXT:000009279	denotes	Sam68
T5589	23268-23277	GO:0065007	denotes	modulates
T5590	23282-23300	_FRAGMENT	denotes	differentiation of
T5591	23313-23318	GO:0030154	denotes	cells
T5592	23301-23312	UBERON:0003104	denotes	mesenchymal
T5593	23301-23318	CL:0000134	denotes	mesenchymal cells
T5594	23313-23318	CL_GO_EXT:cell	denotes	cells
T5595	24284-24288	CL_GO_EXT:cell	denotes	cell
T5596	24321-24330	UBERON:0000922	denotes	embryonic
T5597	24321-24330	_FRAGMENT	denotes	embryonic
T5598	24369-24374	CL:0002321	denotes	cells
T5599	24331-24342	UBERON:0003104	denotes	mesenchymal
T5600	24331-24342	_FRAGMENT	denotes	mesenchymal
T5601	24369-24374	CL:0000134	denotes	cells
T5602	24369-24374	CL_GO_EXT:cell	denotes	cells
T5603	24402-24407	PR_EXT:000000164	denotes	BMP-2
T5604	24416-24426	CL:0000062	denotes	osteoblast
T5605	24427-24442	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T5606	24498-24508	GO:0010467	denotes	expression
T5607	24516-24527	PR_EXT:000030444	denotes	osteocalcin
T5608	24529-24532	PR_EXT:000030444	denotes	OCN
T5609	24534-24538	SO_EXT:0000704	denotes	gene
T5610	24545-24559	_FRAGMENT	denotes	Populations of
T5611	24570-24575	UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population	denotes	cells
T5612	24570-24575	CL_GO_EXT:cell	denotes	cells
T5613	24583-24594	GO:0009294	denotes	transfected
T5614	24665-24672	SO_EXT:0000313	denotes	hairpin
T5615	24681-24686	PR_EXT:000009279	denotes	Sam68
T5616	24716-24725	CHEBI:17939	denotes	puromycin
T5617	24731-24741	GO:0010467	denotes	expression
T5618	24745-24750	PR_EXT:000009279	denotes	Sam68
T5619	24826-24833	PR_EXT:000003676	denotes	β-actin
T5620	24868-24878	CL:0000062	denotes	Osteoblast
T5621	24879-24894	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T5622	24919-24929	GO:0010467	denotes	expressing
T5623	24982-24987	PR_EXT:000000164	denotes	BMP-2
T5624	25017-25027	GO:0010467	denotes	expression
T5625	25031-25034	PR_EXT:000030444	denotes	OCN
T5626	25039-25046	PR_EXT:000003676	denotes	β-actin
T5627	25047-25052	CHEBI_SO_EXT:mRNA	denotes	mRNAs
T5628	25086-25088	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T5629	25109-25119	GO:0010467	denotes	expressing
T5630	25120-25125	CL_GO_EXT:cell	denotes	cells
T5631	25154-25164	CL:0000062	denotes	osteoblast
T5632	25197-25202	CL_GO_EXT:cell	denotes	cells
T5633	25223-25233	GO:0010467	denotes	expression
T5634	25237-25240	PR_EXT:000030444	denotes	OCN
T5635	26164-26169	PR_EXT:000009279	denotes	Sam68
T5636	26169-26170	SO_EXT:sequence_nullness_or_absence	denotes	−
T5637	26171-26172	SO_EXT:sequence_nullness_or_absence	denotes	−
T5638	26173-26192	UBERON:0007195	denotes	bone marrow stromal
T5639	26173-26198	CL:0010001	denotes	bone marrow stromal cells
T5640	26193-26198	CL_GO_EXT:cell	denotes	cells
T5641	26239-26256	SO_EXT:0002031	denotes	short hairpin RNA
T5642	26253-26256	CHEBI_SO_EXT:RNA	denotes	RNA
T5643	26258-26263	SO_EXT:0002031	denotes	shRNA
T5644	26307-26311	UBERON_EXT:bone_element_or_tissue	denotes	bone
T5645	26337-26341	NCBITaxon:10088	denotes	mice
T5646	26369-26375	UBERON:0002371	denotes	marrow
T5647	26428-26432	UBERON_EXT:bone_element_or_tissue	denotes	bone
T5648	26458-26463	PR_EXT:000009279	denotes	Sam68
T5649	26463-26464	SO_EXT:normal_or_wild_type_or_present	denotes	+
T5650	26465-26466	SO_EXT:normal_or_wild_type_or_present	denotes	+
T5651	26471-26476	PR_EXT:000009279	denotes	Sam68
T5652	26476-26477	SO_EXT:sequence_nullness_or_absence	denotes	−
T5653	26478-26479	SO_EXT:sequence_nullness_or_absence	denotes	−
T5654	26480-26484	NCBITaxon:10088	denotes	mice
T5655	26547-26553	UBERON:0000479	denotes	tissue
T5656	26577-26583	UBERON:0002371	denotes	marrow
T5657	26584-26594	CL:0000136	denotes	adipocytes
T5658	26641-26653	CHEBI_EXT:51217	denotes	fluorochrome
T5659	26654-26662	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeling
T5660	26722-26727	PR_EXT:000009279	denotes	Sam68
T5661	26727-26728	SO_EXT:normal_or_wild_type_or_present	denotes	+
T5662	26729-26730	SO_EXT:normal_or_wild_type_or_present	denotes	+
T5663	26731-26735	NCBITaxon:10088	denotes	mice
T5664	26768-26783	UBERON:0002483	denotes	trabecular bone
T5665	26849-26855	UBERON:0002371	denotes	marrow
T5666	26895-26907	CHEBI_EXT:51217	denotes	fluorochrome
T5667	26908-26914	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	labels
T5668	26975-26980	UBERON:0001474	denotes	bones
T5669	26997-27002	PR_EXT:000009279	denotes	Sam68
T5670	27002-27003	SO_EXT:sequence_nullness_or_absence	denotes	−
T5671	27004-27005	SO_EXT:sequence_nullness_or_absence	denotes	−
T5672	27006-27010	NCBITaxon:10088	denotes	mice
T5673	27056-27060	NCBITaxon:10088	denotes	mice
T5674	27071-27079	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T5675	27109-27114	PR_EXT:000009279	denotes	Sam68
T5676	27115-27124	GO:0065007	denotes	regulates
T5677	27129-27147	_FRAGMENT	denotes	differentiation of
T5678	27172-27177	GO:0030154	denotes	cells
T5679	27148-27159	UBERON:0002371	denotes	bone marrow
T5680	27148-27177	CL:0002540	denotes	bone marrow mesenchymal cells
T5681	27160-27171	UBERON:0003104	denotes	mesenchymal
T5682	27172-27177	CL_GO_EXT:cell	denotes	cells
T5683	27189-27198	CL:0000136	denotes	adipocyte
T5684	27199-27214	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T5685	27227-27237	CL:0000062	denotes	osteoblast
T5686	27238-27253	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T5687	27257-27262	GO:0007568	denotes	aging
T5688	27263-27267	UBERON_EXT:bone_element_or_tissue	denotes	bone
T6916	27996-28007	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T6917	28016-28021	PR_EXT:000009279	denotes	Sam68
T6918	28028-28036	GO:0065007	denotes	modulate
T6919	28037-28048	UBERON:0002371	denotes	bone marrow
T6920	28037-28071	CL:0002540	denotes	bone marrow mesenchymal stem cells
T6921	28049-28060	UBERON:0003104	denotes	mesenchymal
T6922	28066-28071	CL_GO_EXT:cell	denotes	cells
T6923	28079-28084	PR_EXT:000009279	denotes	Sam68
T6924	28084-28085	SO_EXT:sequence_nullness_or_absence	denotes	−
T6925	28086-28087	SO_EXT:sequence_nullness_or_absence	denotes	−
T6926	28088-28092	NCBITaxon:10088	denotes	mice
T6927	28134-28138	UBERON_EXT:bone_element_or_tissue	denotes	bone
T6928	28158-28167	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T6929	28181-28185	GO_PATO_EXT:aging_or_agedness	denotes	Aged
T6930	28198-28203	PR_EXT:000009279	denotes	Sam68
T6931	28203-28204	SO_EXT:sequence_nullness_or_absence	denotes	−
T6932	28205-28206	SO_EXT:sequence_nullness_or_absence	denotes	−
T6933	28207-28211	NCBITaxon:10088	denotes	mice
T6934	28229-28233	UBERON_EXT:bone_element_or_tissue	denotes	bone
T6935	28263-28268	PR_EXT:000009279	denotes	Sam68
T6936	28268-28269	SO_EXT:normal_or_wild_type_or_present	denotes	+
T6937	28270-28271	SO_EXT:normal_or_wild_type_or_present	denotes	+
T6938	28289-28298	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T6939	28333-28337	UBERON_EXT:bone_element_or_tissue	denotes	bone
T6940	28368-28375	NCBITaxon:40674	denotes	mammals
T6941	28387-28392	PR_EXT:000009279	denotes	Sam68
T6942	28392-28393	SO_EXT:sequence_nullness_or_absence	denotes	−
T6943	28394-28395	SO_EXT:sequence_nullness_or_absence	denotes	−
T6944	28396-28403	NCBITaxon:33208	denotes	animals
T6945	28420-28424	UBERON_EXT:bone_element_or_tissue	denotes	bone
T6947	28446-28464	_FRAGMENT	denotes	differentiation of
T6948	28482-28487	GO:0030154	denotes	cells
T6949	28465-28476	UBERON:0002371	denotes	bone marrow
T6950	28465-28476	_FRAGMENT	denotes	bone marrow
T6951	28482-28487	CL:0002092	denotes	cells
T6952	28477-28487	CL:0000034	denotes	stem cells
T6953	28482-28487	CL_GO_EXT:cell	denotes	cells
T6954	28502-28507	PR_EXT:000009279	denotes	Sam68
T6955	28507-28508	SO_EXT:sequence_nullness_or_absence	denotes	−
T6956	28509-28510	SO_EXT:sequence_nullness_or_absence	denotes	−
T6957	28511-28515	NCBITaxon:10088	denotes	mice
T6958	28520-28529	UBERON:0000922	denotes	embryonic
T6959	28520-28529	_FRAGMENT	denotes	embryonic
T6960	28568-28573	CL:0002321	denotes	cells
T6961	28530-28541	UBERON:0003104	denotes	mesenchymal
T6962	28530-28541	_FRAGMENT	denotes	mesenchymal
T6963	28568-28573	CL:0000134	denotes	cells
T6964	28568-28573	CL_GO_EXT:cell	denotes	cells
T6965	28597-28602	PR_EXT:000009279	denotes	Sam68
T6966	28603-28608	SO_EXT:0002031	denotes	shRNA
T6967	28639-28649	CL:0000062	denotes	osteoblast
T6968	28650-28665	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T6969	28711-28716	PR_EXT:000009279	denotes	Sam68
T6970	28726-28736	CL:0000062	denotes	osteoblast
T6971	28737-28752	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T6972	28804-28809	PR_EXT:000009279	denotes	Sam68
T6973	28809-28810	SO_EXT:sequence_nullness_or_absence	denotes	−
T6974	28811-28812	SO_EXT:sequence_nullness_or_absence	denotes	−
T6975	28813-28820	NCBITaxon:33208	denotes	animals
T6976	28863-28872	CL:0000136	denotes	adipocyte
T6977	28873-28888	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T6978	28903-28908	PR_EXT:000009279	denotes	Sam68
T6979	28908-28909	SO_EXT:normal_or_wild_type_or_present	denotes	+
T6980	28910-28911	SO_EXT:normal_or_wild_type_or_present	denotes	+
T6981	28948-28959	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T6982	28969-28974	PR_EXT:000009279	denotes	Sam68
T6983	28981-28989	GO:0065007	denotes	regulate
T6984	29010-29020	GO:0060612	denotes	adipogenic
T6985	29025-29035	GO:0001503	denotes	osteogenic
T6986	29036-29051	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T6987	29059-29070	UBERON:0002371	denotes	bone marrow
T6988	29071-29082	UBERON:0003104	denotes	mesenchymal
T6989	29084-29089	PR_EXT:000009279	denotes	Sam68
T6990	29090-29097	CHEBI_PR_EXT:protein	denotes	protein
T6991	29098-29108	GO:0010467	denotes	expression
T6992	29148-29153	NCBITaxon:10088	denotes	mouse
T6993	29154-29160	UBERON:0000922	denotes	embryo
T6994	29215-29220	PR_EXT:000009279	denotes	Sam68
T6995	29221-29225	CHEBI_SO_EXT:mRNA	denotes	mRNA
T6996	29239-29248	GO:0010467	denotes	expressed
T6997	29266-29271	PR_EXT:000009279	denotes	Sam68
T6998	29288-29293	UBERON:0000955	denotes	brain
T6999	29295-29300	UBERON:0000948	denotes	heart
T7000	29306-29315	UBERON:0000160	denotes	intestine
T7001	29342-29347	UBERON:0002107	denotes	liver
T7002	29349-29353	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7003	29359-29365	UBERON:0002113	denotes	kidney
T7004	29388-29406	UBERON:0000323	denotes	late-stage embryos
T7005	29413-29423	GO:0010467	denotes	expression
T7006	29483-29488	PR_EXT:000009279	denotes	Sam68
T7007	29492-29499	CL:0000540	denotes	neurons
T7008	29531-29541	UBERON:0000160	denotes	intestinal
T7009	29531-29545	PR_EXT:000013434	denotes	intestinal SIK
T7010	29546-29552	UBERON:0000310	denotes	breast
T7011	29546-29565	PR_EXT:000013434	denotes	breast tumor kinase
T7012	29559-29565	GO_EXT:0016301	denotes	kinase
T7013	29576-29586	GO:0010467	denotes	expression
T7014	29590-29595	PR_EXT:000009279	denotes	Sam68
T7015	29615-29620	GO:0007568	denotes	aging
T7016	29621-29640	UBERON:0007195	denotes	bone marrow stromal
T7017	29621-29646	CL:0010001	denotes	bone marrow stromal cells
T7018	29641-29646	CL_GO_EXT:cell	denotes	cells
T7019	29653-29665	GO:0007568	denotes	senescencing
T7020	29672-29677	CL_GO_EXT:cell	denotes	cells
T7021	29714-29719	PR_EXT:000009279	denotes	Sam68
T7022	29723-29735	CL:0000138	denotes	chondrocytes
T7023	29737-29748	CL:0000062	denotes	osteoblasts
T7024	29753-29764	CL:0000092	denotes	osteoclasts
T7025	29779-29788	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T7026	29793-29797	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7027	29831-29838	CHEBI_PR_EXT:protein	denotes	protein
T7028	29842-29850	UBERON:0004288	denotes	skeletal
T7029	29842-29862	GO:0001501	denotes	skeletal development
T7030	29868-29873	PR_EXT:000009279	denotes	Sam68
T7031	29873-29874	SO_EXT:sequence_nullness_or_absence	denotes	−
T7032	29875-29876	SO_EXT:sequence_nullness_or_absence	denotes	−
T7033	29877-29881	NCBITaxon:10088	denotes	mice
T7034	29960-29966	SO_EXT:0000417	denotes	domain
T7035	29971-29978	SO_EXT:sequence_deletion_process	denotes	deleted
T7036	30014-30019	PR_EXT:000009279	denotes	Sam68
T7037	30019-30020	SO_EXT:sequence_nullness_or_absence	denotes	−
T7038	30021-30022	SO_EXT:sequence_nullness_or_absence	denotes	−
T7039	30023-30027	NCBITaxon:10088	denotes	mice
T7040	30040-30049	UBERON:0000113	denotes	adulthood
T7041	30120-30125	PR_EXT:000009279	denotes	Sam68
T7042	30213-30218	PR_EXT:000009280	denotes	SLM-1
T7043	30223-30228	PR_EXT:000009281	denotes	SLM-2
T7044	30250-30255	PR_EXT:000009279	denotes	Sam68
T7045	30279-30288	UBERON:0000922	denotes	embryonic
T7046	30279-30300	GO:0009790	denotes	embryonic development
T7047	30329-30334	PR_EXT:000009279	denotes	Sam68
T7048	30334-30335	SO_EXT:sequence_nullness_or_absence	denotes	−
T7049	30336-30337	SO_EXT:sequence_nullness_or_absence	denotes	−
T7050	30351-30356	PR_EXT:000009279	denotes	Sam68
T7051	30356-30357	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7052	30358-30359	SO_EXT:sequence_nullness_or_absence	denotes	-
T7053	30360-30364	NCBITaxon_UBERON_EXT:pup	denotes	pups
T7054	30371-30377	GO_EXT:killing	denotes	killed
T7055	30387-30392	PR_EXT:000009279	denotes	Sam68
T7056	30392-30393	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7057	30394-30395	SO_EXT:sequence_nullness_or_absence	denotes	-
T7058	30507-30512	UBERON:0007023	denotes	Adult
T7059	30513-30518	PR_EXT:000009279	denotes	Sam68
T7060	30518-30519	SO_EXT:sequence_nullness_or_absence	denotes	−
T7061	30520-30521	SO_EXT:sequence_nullness_or_absence	denotes	−
T7062	30522-30526	NCBITaxon:10088	denotes	mice
T7063	30541-30550	UBERON:0000104	denotes	life span
T7064	30583-30588	PR_EXT:000009279	denotes	Sam68
T7065	30588-30589	SO_EXT:sequence_nullness_or_absence	denotes	−
T7066	30590-30591	SO_EXT:sequence_nullness_or_absence	denotes	−
T7067	30592-30597	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T7068	30619-30624	PR_EXT:000009279	denotes	Sam68
T7069	30624-30625	SO_EXT:sequence_nullness_or_absence	denotes	−
T7070	30626-30627	SO_EXT:sequence_nullness_or_absence	denotes	−
T7071	30628-30635	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T7072	30685-30689	NCBITaxon_UBERON_EXT:pup	denotes	pups
T7073	30740-30744	PR_EXT:000007598	denotes	FosB
T7074	30744-30745	SO_EXT:sequence_nullness_or_absence	denotes	−
T7075	30746-30747	SO_EXT:sequence_nullness_or_absence	denotes	−
T7076	30748-30752	NCBITaxon:10088	denotes	mice
T7077	30759-30764	UBERON:0001977	denotes	Serum
T7078	30775-30783	CHEBI_EXT:50114	denotes	estrogen
T7079	30797-30802	GO:0007568	denotes	aging
T7080	30803-30808	PR_EXT:000009279	denotes	Sam68
T7081	30808-30809	SO_EXT:sequence_nullness_or_absence	denotes	−
T7082	30810-30811	SO_EXT:sequence_nullness_or_absence	denotes	−
T7083	30812-30819	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T7084	30846-30852	CHEBI_PR_EXT:leptin	denotes	leptin
T7085	30873-30877	GO_PATO_EXT:aging_or_agedness	denotes	aged
T7086	30878-30883	PR_EXT:000009279	denotes	Sam68
T7087	30883-30884	SO_EXT:sequence_nullness_or_absence	denotes	−
T7088	30885-30886	SO_EXT:sequence_nullness_or_absence	denotes	−
T7089	30887-30894	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T7090	30900-30904	GO_PATO_EXT:aging_or_agedness	denotes	aged
T7091	30905-30910	PR_EXT:000009279	denotes	Sam68
T7092	30910-30911	SO_EXT:sequence_nullness_or_absence	denotes	−
T7093	30912-30913	SO_EXT:sequence_nullness_or_absence	denotes	−
T7094	30914-30921	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T7095	31053-31058	GO:0007568	denotes	aging
T7096	31134-31140	CHEBI_PR_EXT:leptin	denotes	leptin
T7097	31224-31230	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T7098	31251-31259	UBERON:0004288	denotes	skeletal
T7099	31286-31291	PR_EXT:000009279	denotes	Sam68
T7100	31291-31292	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7101	31293-31294	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7102	31299-31304	PR_EXT:000009279	denotes	Sam68
T7103	31304-31305	SO_EXT:sequence_nullness_or_absence	denotes	−
T7104	31306-31307	SO_EXT:sequence_nullness_or_absence	denotes	−
T7105	31308-31312	NCBITaxon:10088	denotes	mice
T7106	31325-31329	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7107	31352-31356	GO_PATO_EXT:aging_or_agedness	denotes	aged
T7108	31357-31362	PR_EXT:000009279	denotes	Sam68
T7109	31362-31363	SO_EXT:sequence_nullness_or_absence	denotes	−
T7110	31364-31365	SO_EXT:sequence_nullness_or_absence	denotes	−
T7111	31366-31370	NCBITaxon:10088	denotes	mice
T7112	31469-31479	CL:0000062	denotes	osteoblast
T7113	31484-31494	CL:0000092	denotes	osteoclast
T7114	31532-31537	PR_EXT:000009279	denotes	Sam68
T7115	31538-31548	GO:0065007	denotes	regulatory
T7116	31549-31556	CHEBI_PR_EXT:protein	denotes	protein
T7117	31558-31561	PR_EXT:000027234	denotes	Src
T7118	31633-31638	PR_EXT:000009279	denotes	Sam68
T7119	31638-31639	SO_EXT:sequence_nullness_or_absence	denotes	−
T7120	31640-31641	SO_EXT:sequence_nullness_or_absence	denotes	−
T7121	31642-31653	CL:0000092	denotes	osteoclasts
T7122	31667-31670	PR_EXT:000027234	denotes	Src
T7123	31671-31679	CHEBI_SO_EXT:tyrosine	denotes	tyrosine
T7124	31671-31686	GO_EXT:0004713	denotes	tyrosine kinase
T7125	31715-31719	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7126	31715-31730	GO:0046849	denotes	bone remodeling
T7127	31736-31739	PR_EXT:000027234	denotes	Src
T7128	31739-31740	SO_EXT:sequence_nullness_or_absence	denotes	−
T7129	31741-31742	SO_EXT:sequence_nullness_or_absence	denotes	−
T7130	31743-31747	NCBITaxon:10088	denotes	mice
T7131	31748-31752	GO:0016265	denotes	died
T7132	31852-31862	CL:0000092	denotes	osteoclast
T7133	31910-31921	CL:0000092	denotes	osteoclasts
T7134	31937-31942	PR_EXT:000009279	denotes	Sam68
T7135	31942-31943	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7136	31944-31945	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7137	31950-31955	PR_EXT:000009279	denotes	Sam68
T7138	31955-31956	SO_EXT:sequence_nullness_or_absence	denotes	−
T7139	31957-31958	SO_EXT:sequence_nullness_or_absence	denotes	−
T7140	31959-31963	NCBITaxon:10088	denotes	mice
T7141	31975-31981	UBERON:0001751	denotes	dentin
T7142	32042-32047	PR_EXT:000009279	denotes	Sam68
T7143	32047-32048	SO_EXT:sequence_nullness_or_absence	denotes	−
T7144	32049-32050	SO_EXT:sequence_nullness_or_absence	denotes	−
T7145	32051-32062	CL:0000092	denotes	osteoclasts
T7146	32085-32090	PR_EXT:000009279	denotes	Sam68
T7225	33390-33394	NCBITaxon:10088	denotes	mice
T7147	32090-32091	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7148	32092-32093	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7149	32094-32105	CL:0000092	denotes	osteoclasts
T7150	32197-32201	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7151	32202-32212	GO:0008152	denotes	metabolism
T7152	32229-32234	PR_EXT:000009279	denotes	Sam68
T7153	32234-32235	SO_EXT:sequence_nullness_or_absence	denotes	−
T7154	32236-32237	SO_EXT:sequence_nullness_or_absence	denotes	−
T7155	32238-32242	NCBITaxon:10088	denotes	mice
T7156	32301-32306	PR_EXT:000009279	denotes	Sam68
T7157	32306-32307	SO_EXT:sequence_nullness_or_absence	denotes	−
T7158	32308-32309	SO_EXT:sequence_nullness_or_absence	denotes	−
T7159	32310-32314	NCBITaxon:10088	denotes	mice
T7160	32347-32351	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7161	32347-32362	GO:0045453	denotes	bone resorption
T7162	32377-32386	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T7163	32435-32439	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7164	32435-32450	GO:0045453	denotes	bone resorption
T7165	32472-32482	CL:0000092	denotes	osteoclast
T7166	32571-32576	PR_EXT:000009279	denotes	Sam68
T7167	32576-32577	SO_EXT:sequence_nullness_or_absence	denotes	−
T7168	32578-32579	SO_EXT:sequence_nullness_or_absence	denotes	−
T7169	32580-32584	NCBITaxon:10088	denotes	mice
T7170	32605-32609	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7171	32678-32683	PR_EXT:000009279	denotes	Sam68
T7172	32683-32684	SO_EXT:sequence_nullness_or_absence	denotes	−
T7173	32685-32686	SO_EXT:sequence_nullness_or_absence	denotes	−
T7174	32687-32691	NCBITaxon:10088	denotes	mice
T7175	32692-32702	CL:0000092	denotes	osteoclast
T7176	32741-32745	UBERON:0000104	denotes	life
T7177	32773-32777	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7178	32834-32852	_FRAGMENT	denotes	differentiation of
T7179	32881-32886	GO:0030154	denotes	cells
T7180	32853-32860	_FRAGMENT	denotes	primary
T7181	32881-32886	CL:0000001	denotes	cells
T7182	32861-32880	UBERON:0007195	denotes	bone marrow stromal
T7183	32861-32886	CL:0010001	denotes	bone marrow stromal cells
T7184	32881-32886	CL_GO_EXT:cell	denotes	cells
T7185	32903-32908	PR_EXT:000009279	denotes	Sam68
T7186	32908-32909	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7187	32910-32911	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7188	32916-32921	PR_EXT:000009279	denotes	Sam68
T7189	32921-32922	SO_EXT:sequence_nullness_or_absence	denotes	−
T7190	32923-32924	SO_EXT:sequence_nullness_or_absence	denotes	−
T7191	32925-32929	NCBITaxon:10088	denotes	mice
T7192	32940-32950	CL:0000062	denotes	osteoblast
T7193	32971-32981	GO:0001503	denotes	osteogenic
T7194	33011-33016	CL_GO_EXT:cell	denotes	cells
T7195	33034-33039	PR_EXT:000009279	denotes	Sam68
T7196	33039-33040	SO_EXT:sequence_nullness_or_absence	denotes	−
T7197	33041-33042	SO_EXT:sequence_nullness_or_absence	denotes	−
T7198	33043-33047	NCBITaxon:10088	denotes	mice
T7199	33125-33132	_FRAGMENT	denotes	primary
T7200	33153-33158	CL:0000001	denotes	cells
T7201	33133-33152	UBERON:0007195	denotes	bone marrow stromal
T7202	33133-33158	CL:0010001	denotes	bone marrow stromal cells
T7203	33153-33158	CL_GO_EXT:cell	denotes	cells
T7204	33164-33168	GO_PATO_EXT:aging_or_agedness	denotes	aged
T7205	33169-33174	PR_EXT:000009279	denotes	Sam68
T7206	33174-33175	SO_EXT:sequence_nullness_or_absence	denotes	−
T7207	33176-33177	SO_EXT:sequence_nullness_or_absence	denotes	−
T7208	33178-33182	NCBITaxon:10088	denotes	mice
T7209	33220-33229	UBERON:0000922	denotes	embryonic
T7210	33220-33229	_FRAGMENT	denotes	embryonic
T7211	33268-33273	CL:0002321	denotes	cells
T7212	33230-33241	UBERON:0003104	denotes	mesenchymal
T7213	33230-33241	_FRAGMENT	denotes	mesenchymal
T7214	33268-33273	CL:0000134	denotes	cells
T7215	33268-33273	CL_GO_EXT:cell	denotes	cells
T7216	33297-33302	PR_EXT:000009279	denotes	Sam68
T7217	33303-33308	SO_EXT:0002031	denotes	shRNA
T7218	33315-33329	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T7219	33335-33346	CL:0000062	denotes	osteoblasts
T7220	33352-33356	PR_EXT:000000164	denotes	BMP2
T7221	33376-33380	GO_PATO_EXT:aging_or_agedness	denotes	aged
T7222	33381-33386	PR_EXT:000009279	denotes	Sam68
T7223	33386-33387	SO_EXT:sequence_nullness_or_absence	denotes	−
T7224	33388-33389	SO_EXT:sequence_nullness_or_absence	denotes	−
T7226	33410-33415	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T7227	33416-33427	UBERON:0002371	denotes	bone marrow
T7228	33455-33460	PR_EXT:000009279	denotes	Sam68
T7229	33461-33462	SO_EXT:sequence_nullness_or_absence	denotes	−
T7230	33463-33464	SO_EXT:sequence_nullness_or_absence	denotes	−
T7231	33465-33469	NCBITaxon:10088	denotes	mice
T7232	33484-33493	CL:0000136	denotes	adipocyte
T7233	33494-33509	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T7234	33525-33530	PR_EXT:000009279	denotes	Sam68
T7235	33531-33540	GO:0065007	denotes	regulates
T7236	33546-33555	CL:0000136	denotes	adipocyte
T7237	33560-33570	CL:0000062	denotes	osteoblast
T7238	33571-33586	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T7239	33612-33617	PR_EXT:000009279	denotes	Sam68
T7240	33631-33634	CHEBI_SO_EXT:RNA	denotes	RNA
T7241	33635-33642	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T7242	33643-33650	CHEBI_PR_EXT:protein	denotes	protein
T7243	33654-33662	GO:0065007	denotes	regulate
T7244	33663-33674	UBERON:0003104	denotes	mesenchymal
T7245	33663-33679	CL:0000134	denotes	mesenchymal cell
T7246	33675-33679	CL_GO_EXT:cell	denotes	cell
T7247	33675-33695	GO:0030154	denotes	cell differentiation
T7248	33747-33750	CHEBI_SO_EXT:RNA	denotes	RNA
T7249	33767-33776	GO:0065007	denotes	regulates
T7250	33812-33822	CL:0000062	denotes	osteoblast
T7251	33846-33849	PR_EXT:000027234	denotes	Src
T7252	33849-33850	SO_EXT:sequence_nullness_or_absence	denotes	−
T7253	33851-33852	SO_EXT:sequence_nullness_or_absence	denotes	−
T7254	33853-33857	NCBITaxon:10088	denotes	mice
T7255	33910-33914	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7256	33927-33932	PR_EXT:000009279	denotes	Sam68
T7257	33932-33933	SO_EXT:sequence_nullness_or_absence	denotes	−
T7258	33934-33935	SO_EXT:sequence_nullness_or_absence	denotes	−
T7259	33936-33940	NCBITaxon:10088	denotes	mice
T7260	33966-33975	GO:0065007	denotes	regulated
T7272	34203-34208	PR_EXT:000002107	denotes	RANKL
T7273	34225-34236	CL:0000092	denotes	osteoclasts
T7274	34274-34280	CHEBI_PR_EXT:leptin	denotes	leptin
T7275	34291-34295	GO_PATO_EXT:aging_or_agedness	denotes	aged
T7276	34296-34301	PR_EXT:000009279	denotes	Sam68
T7277	34301-34302	SO_EXT:sequence_nullness_or_absence	denotes	−
T7278	34303-34304	SO_EXT:sequence_nullness_or_absence	denotes	−
T7279	34305-34309	NCBITaxon:10088	denotes	mice
T7280	34335-34339	NCBITaxon:10088	denotes	mice
T7281	34354-34358	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7282	34384-34388	GO_PATO_EXT:aging_or_agedness	denotes	aged
T7283	34436-34442	CHEBI_PR_EXT:leptin	denotes	leptin
T7284	34479-34484	PR_EXT:000009279	denotes	Sam68
T7285	34484-34485	SO_EXT:sequence_nullness_or_absence	denotes	−
T7286	34486-34487	SO_EXT:sequence_nullness_or_absence	denotes	−
T7287	34488-34492	NCBITaxon:10088	denotes	mice
T7288	34518-34524	CHEBI_PR_EXT:leptin	denotes	leptin
T7289	34568-34573	UBERON:0001977	denotes	serum
T7290	34577-34582	PR_EXT:000009279	denotes	Sam68
T7291	34582-34583	SO_EXT:sequence_nullness_or_absence	denotes	−
T7292	34584-34585	SO_EXT:sequence_nullness_or_absence	denotes	−
T7293	34586-34590	NCBITaxon:10088	denotes	mice
T7294	34620-34625	PR_EXT:000009279	denotes	Sam68
T7295	34633-34643	GO:0065007	denotes	regulating
T7296	34644-34648	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7297	34649-34659	GO:0008152	denotes	metabolism
T7298	34704-34709	PR_EXT:000009279	denotes	Sam68
T7299	34727-34733	CHEBI_PR_EXT:leptin	denotes	leptin
T7300	34757-34761	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7301	34757-34772	GO:0045453	denotes	bone resorption
T7302	34781-34807	UBERON:0000013	denotes	sympathetic nervous system
T7303	34831-34836	PR_EXT:000009279	denotes	Sam68
T7304	34844-34854	CL:0000062	denotes	osteoblast
T7305	34868-34877	CL:0000136	denotes	adipocyte
T7306	34879-34894	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T7307	34929-34940	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T7308	34950-34955	PR_EXT:000009279	denotes	Sam68
T7309	34959-34963	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7310	34964-34974	GO:0008152	denotes	metabolism
T7311	34979-34990	UBERON:0002371	denotes	bone marrow
T7312	34979-35012	CL:0002540	denotes	bone marrow mesenchymal stem cell
T7313	34991-35002	UBERON:0003104	denotes	mesenchymal
T7314	35008-35012	CL_GO_EXT:cell	denotes	cell
T7315	35008-35028	GO:0030154	denotes	cell differentiation
T7316	35034-35038	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7317	35061-35066	PR_EXT:000009279	denotes	Sam68
T7318	35066-35067	SO_EXT:sequence_nullness_or_absence	denotes	−
T7319	35068-35069	SO_EXT:sequence_nullness_or_absence	denotes	−
T7320	35070-35074	NCBITaxon:10088	denotes	mice
T7321	35086-35096	CHEBI_EXT:35222	denotes	inhibitors
T7322	35100-35105	PR_EXT:000009279	denotes	Sam68
T7323	35132-35136	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7324	35186-35191	PR_EXT:000009279	denotes	Sam68
T7325	35192-35202	GO:0010467	denotes	expression
T7326	35229-35238	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T7327	35242-35248	NCBITaxon:9606	denotes	humans
T7328	35281-35287	UBERON:0002371	denotes	marrow
T7329	35288-35297	CL:0000136	denotes	adipocyte
T7330	35362-35368	NCBITaxon:33208	denotes	animal
T7331	35384-35389	GO:0007568	denotes	aging
T7332	35390-35394	UBERON_EXT:bone_element_or_tissue	denotes	bone
T8832	35572-35581	UBERON:0000922	denotes	embryonic
T8833	35582-35586	NCBITaxon:10088	denotes	mice
T8834	35611-35619	GO:0007565	denotes	pregnant
T8835	35676-35692	CHEBI_EXT:paraformaldehye	denotes	paraformaldehyde
T8836	35933-35938	PR_EXT:000009279	denotes	Sam68
T8837	35939-35947	GO:0042571	denotes	antibody
T8838	36000-36011	CHEBI:51686	denotes	hematoxylin
T8839	36013-36018	UBERON:0000922	denotes	Adult
T8840	36019-36023	NCBITaxon:10088	denotes	mice
T8841	36043-36053	UBERON:0001179	denotes	peritoneal
T8842	36076-36083	CHEBI:51903	denotes	calcein
T8843	36107-36119	CHEBI:27902	denotes	tetracycline
T8844	36139-36148	GO_EXT:killing	denotes	sacrifice
T8845	36152-36157	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	label
T8846	36221-36237	CHEBI_EXT:paraformaldehye	denotes	paraformaldehyde
T8847	36267-36272	UBERON:0000981	denotes	femur
T8848	36277-36282	UBERON:0000979	denotes	tibia
T8849	36300-36322	CHEBI_EXT:poly_methyl_methacrylate	denotes	polymethylmethacrylate
T8850	36324-36327	CHEBI:34840	denotes	MMA
T8851	36334-36341	CHEBI:60004	denotes	mixture
T8852	36349-36352	CHEBI:34840	denotes	MMA
T8853	36361-36379	CHEBI:34288	denotes	glycolmethacrylate
T8854	36381-36384	CHEBI:34288	denotes	GMA
T8855	36417-36420	CHEBI:34840	denotes	MMA
T8856	36430-36437	UBERON:0000479	denotes	tissues
T8857	36544-36547	CHEBI:34840	denotes	MMA
T8858	36548-36551	CHEBI:34288	denotes	GMA
T8859	36578-36582	PR_EXT:000001937	denotes	TRAP
T8860	36587-36590	GO_PR_EXT:alkaline_phosphatase	denotes	ALP
T8861	37008-37012	UBERON_EXT:bone_element_or_tissue	denotes	Bone
T8862	37017-37024	CHEBI:46662	denotes	Mineral
T9236	37055-37059	NCBITaxon:10088	denotes	mice
T9237	37092-37097	PR_EXT:000009279	denotes	sam68
T9238	37098-37102	SO_EXT:0000704	denotes	gene
T9239	37122-37127	SO_EXT:sequence_cloned_entity	denotes	clone
T9240	37141-37146	PR_EXT:000009279	denotes	Sam68
T9241	37147-37152	SO_EXT:0000147	denotes	exons
T9242	37188-37195	SO_EXT:0001026	denotes	genomic
T9243	37222-37227	PR_EXT:000009279	denotes	Sam68
T9244	37228-37232	SO_EXT:cDNA	denotes	cDNA
T9245	37238-37243	CHEBI_SO_EXT:molecular_probe	denotes	probe
T9246	37259-37264	PR_EXT:000009279	denotes	Sam68
T9247	37265-37276	SO_EXT:genomic_DNA	denotes	genomic DNA
T9248	37273-37276	CHEBI_SO_EXT:DNA	denotes	DNA
T9249	37293-37294	CHEBI_SO_EXT:base	denotes	b
T9250	37309-37313	SO_EXT:0000147	denotes	exon
T9251	37320-37332	SO_EXT:0000852	denotes	part of exon
T9252	37354-37366	SO_EXT:0000852	denotes	part of exon
T9253	37373-37377	SO_EXT:0000147	denotes	exon
T9254	37457-37460	CHEBI_SO_EXT:DNA	denotes	DNA
T9255	37513-37529	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotides
T9256	37594-37600	SO_EXT:0000112	denotes	primer
T9257	37623-37624	CHEBI_SO_EXT:base	denotes	b
T9258	37625-37628	CHEBI_SO_EXT:DNA	denotes	DNA
T9259	37760-37761	CHEBI_SO_EXT:base	denotes	b
T9260	37971-37987	SO_EXT:0001644	denotes	targeting vector
T9261	37993-37998	PR_EXT:000009279	denotes	Sam68
T9262	37999-38007	SO_EXT:sequence_substitution_process	denotes	replaces
T9263	38008-38012	SO_EXT:0000147	denotes	exon
T9264	38019-38031	SO_EXT:0000852	denotes	part of exon
T9265	38041-38049	CHEBI:7507	denotes	neomycin
T9266	38060-38073	SO_EXT:0005853	denotes	gene cassette
T9267	38127-38128	CHEBI_SO_EXT:base	denotes	b
T9268	38129-38132	CHEBI_SO_EXT:DNA	denotes	DNA
T9269	38158-38167	SO_EXT:sequence_linearization	denotes	linearize
T9270	38172-38179	SO_EXT:0000155	denotes	plasmid
T9271	38205-38214	UBERON:0000922	denotes	embryonic
T9272	38205-38219	_FRAGMENT	denotes	embryonic stem
T9273	38225-38230	CL:0002322	denotes	cells
T9274	38221-38223	_FRAGMENT	denotes	ES
T9275	38225-38230	CL_GO_EXT:cell	denotes	cells
T9276	38252-38254	CL:0002322	denotes	ES
T9277	38286-38292	SO_EXT:sequence_cloned_entity	denotes	clones
T9278	38328-38333	PR_EXT:000009279	denotes	Sam68
T9279	38334-38340	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9280	38341-38347	SO_EXT:0001023	denotes	allele
T9281	38394-38402	CL:0002322	denotes	ES cells
T9282	38397-38402	CL_GO_EXT:cell	denotes	cells
T9283	38441-38452	UBERON:0000358	denotes	blastocysts
T9284	38462-38473	GO_EXT:biological_movement_or_translocation_process	denotes	transferred
T9285	38504-38511	NCBITaxon:33208	denotes	animals
T9286	38538-38542	UBERON:0010166	denotes	coat
T9287	38554-38559	GO:0007618	denotes	mated
T9288	38572-38576	NCBITaxon:10088	denotes	mice
T9289	38622-38626	NCBITaxon:10088	denotes	mice
T9290	38670-38674	NCBITaxon:10088	denotes	mice
T9291	38705-38709	NCBITaxon:10088	denotes	mice
T9292	38811-38815	NCBITaxon:10088	denotes	mice
T9714	38913-38918	NCBITaxon:10088	denotes	mouse
T9715	39035-39041	NCBITaxon:33208	denotes	Animal
T9716	39048-39059	SO_EXT:genomic_DNA	denotes	Genomic DNA
T9717	39056-39059	CHEBI_SO_EXT:DNA	denotes	DNA
T9718	39078-39082	UBERON:0002415	denotes	tail
T9719	39130-39137	SO_EXT:0001026	denotes	genomic
T9720	39156-39159	CHEBI_SO_EXT:DNA	denotes	DNA
T9721	39185-39190	CHEBI_SO_EXT:molecular_probe	denotes	probe
T9722	39263-39279	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotides
T9723	39358-39367	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9724	39368-39373	PR_EXT:000009279	denotes	sam68
T9725	39374-39380	SO_EXT:0001023	denotes	allele
T9726	39399-39406	SO_EXT:0001026	denotes	genomic
T9727	39431-39447	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotides
T9728	39532-39537	PR_EXT:000009279	denotes	sam68
T9729	39547-39553	SO_EXT:0001023	denotes	allele
T9730	39572-39579	SO_EXT:0001026	denotes	genomic
T9731	39604-39620	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotides
T9950	39711-39716	UBERON:0001977	denotes	serum
T9951	39733-39738	PR_EXT:000009279	denotes	Sam68
T9952	39738-39739	SO_EXT:normal_or_wild_type_or_present	denotes	+
T9953	39740-39741	SO_EXT:normal_or_wild_type_or_present	denotes	+
T9954	39746-39751	PR_EXT:000009279	denotes	Sam68
T9955	39751-39752	SO_EXT:sequence_nullness_or_absence	denotes	−
T9956	39753-39754	SO_EXT:sequence_nullness_or_absence	denotes	−
T9957	39755-39759	NCBITaxon:10088	denotes	mice
T9958	39849-39853	NCBITaxon:10088	denotes	Mice
T9959	39874-39880	GO_EXT:fatality_or_lethality	denotes	lethal
T9960	39889-39899	CHEBI_EXT:38867	denotes	anesthetic
T9961	40056-40060	UBERON_EXT:body	denotes	Body
T9962	40061-40064	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T9963	40211-40223	CHEBI_EXT:anaesthetic_process	denotes	anesthetized
T9964	40224-40228	NCBITaxon:10088	denotes	mice
T9965	40244-40253	GO_EXT:killing	denotes	sacrifice
T9966	40344-40349	UBERON:0000981	denotes	femur
T9967	40354-40376	UBERON:0004620	denotes	fourth lumbar vertebra
T9968	40399-40406	UBERON:0000479	denotes	tissues
T9969	40436-40452	CHEBI_EXT:paraformaldehye	denotes	paraformaldehyde
T9970	40458-40475	UBERON:0004377	denotes	distal metaphysis
T9971	40817-40822	UBERON:0001977	denotes	Serum
T9972	40837-40840	GO_PR_EXT:alkaline_phosphatase	denotes	ALP
T9973	40877-40883	NCBITaxon:9989	denotes	Rodent
T9974	41023-41028	UBERON:0001977	denotes	serum
T9975	41079-41092	CHEBI:16469	denotes	17β estradiol
T9976	41136-41142	CHEBI_PR_EXT:leptin	denotes	leptin
T9977	41203-41216	PR_EXT:000001393	denotes	interleukin-6
T10343	41257-41267	CL:0000062	denotes	osteoblast
T10344	41272-41282	CL:0000092	denotes	osteoclast
T10345	41293-41304	UBERON:0002371	denotes	Bone marrow
T10346	41326-41331	UBERON:0000979	denotes	tibia
T10347	41336-41342	UBERON:0000981	denotes	femora
T10348	41346-41354	PATO_UBERON_EXT:juvenile_organism	denotes	juvenile
T10349	41366-41371	PR_EXT:000009279	denotes	Sam68
T10350	41371-41372	SO_EXT:normal_or_wild_type_or_present	denotes	+
T10351	41373-41374	SO_EXT:normal_or_wild_type_or_present	denotes	+
T10352	41379-41384	PR_EXT:000009279	denotes	Sam68
T10353	41384-41385	SO_EXT:sequence_nullness_or_absence	denotes	−
T10354	41386-41387	SO_EXT:sequence_nullness_or_absence	denotes	−
T10355	41388-41392	NCBITaxon:10088	denotes	mice
T10356	41403-41410	UBERON:0003891	denotes	stromal
T10357	41403-41416	CL:0000499	denotes	stromal cells
T10358	41411-41416	CL_GO_EXT:cell	denotes	cells
T10359	41441-41456	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T10360	41534-41537	GO_PR_EXT:alkaline_phosphatase	denotes	ALP
T10361	41609-41612	CHEBI_SO_EXT:RNA	denotes	RNA
T10362	41654-41656	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T10363	41673-41683	CL:0000062	denotes	osteoblast
T10364	41692-41696	SO_EXT:0000704	denotes	gene
T10365	41692-41707	GO:0010467	denotes	gene expression
T10366	41748-41759	CL:0000092	denotes	Osteoclasts
T10367	41791-41801	UBERON:0002495	denotes	long bones
T10368	41805-41813	PATO_UBERON_EXT:juvenile_organism	denotes	juvenile
T10369	41814-41819	PR_EXT:000009279	denotes	Sam68
T10370	41819-41820	SO_EXT:normal_or_wild_type_or_present	denotes	+
T10371	41821-41822	SO_EXT:normal_or_wild_type_or_present	denotes	+
T10372	41827-41832	PR_EXT:000009279	denotes	Sam68
T10373	41832-41833	SO_EXT:sequence_nullness_or_absence	denotes	−
T10374	41834-41835	SO_EXT:sequence_nullness_or_absence	denotes	−
T10375	41836-41840	NCBITaxon:10088	denotes	mice
T10376	41903-41908	CL_GO_EXT:cell	denotes	cells
T10377	41947-41953	UBERON:0001751	denotes	dentin
T10378	42005-42009	CL_GO_EXT:cell	denotes	cell
T10379	42079-42095	CHEBI_EXT:paraformaldehye	denotes	paraformaldehyde
T10380	42112-42116	PR_EXT:000001937	denotes	TRAP
T10381	42137-42143	UBERON:0001751	denotes	Dentin
T10382	42190-42195	CL_GO_EXT:cell	denotes	cells
T10383	42205-42223	CHEBI:18219	denotes	ammonium hydroxide
T10384	42267-42269	CHEBI_EXT:gold	denotes	Au
T10385	42270-42272	CHEBI_EXT:palladium	denotes	Pd
T10386	42303-42311	CHEBI:10545	denotes	electron
T10387	42331-42339	CHEBI:10545	denotes	Electron
T10683	42681-42686	NCBITaxon:10088	denotes	mouse
T10684	42687-42696	UBERON:0000922	denotes	embryonic
T10685	42697-42707	CL:0000057	denotes	fibroblast
T10686	42725-42734	CL:0000136	denotes	adipocyte
T10687	42735-42750	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T10688	42789-42796	UBERON:0000922	denotes	embryos
T10689	42879-42888	CL:0000136	denotes	adipocyte
T10690	42889-42904	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T10691	42973-42987	CL:0000010	denotes	Cultured cells
T10692	42982-42987	CL_GO_EXT:cell	denotes	cells
T10796	43036-43039	CHEBI_SO_EXT:RNA	denotes	RNA
T10797	43056-43058	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T10798	43073-43085	GO:0060612	denotes	adipogenesis
T10799	43089-43094	PR_EXT:000009279	denotes	Sam68
T10800	43094-43095	SO_EXT:sequence_nullness_or_absence	denotes	−
T10801	43096-43097	SO_EXT:sequence_nullness_or_absence	denotes	−
T10802	43110-43118	CL_GO_EXT:cell	denotes	cellular
T10803	43119-43122	CHEBI_SO_EXT:RNA	denotes	RNA
T10804	43146-43153	CHEBI_EXT:33893	denotes	reagent
T10805	43252-43255	CHEBI_SO_EXT:RNA	denotes	RNA
T10806	43267-43286	GO:0001171	denotes	reverse-transcribed
T10807	43292-43296	SO_EXT:cDNA	denotes	cDNA
T10808	43328-43330	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T10809	43357-43372	GO_EXT:transcription	denotes	transcriptional
T10810	43382-43387	GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase	denotes	GAPDH
T10811	43413-43420	SO_EXT:0000112	denotes	primers
T10812	43443-43453	GO:0060612	denotes	adipogenic
T10813	43454-43469	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T10814	43471-43475	PR_EXT:000009365	denotes	KLF5
T10815	43540-43545	PR_EXT:000013058	denotes	PPARγ
T10816	43623-43630	PR_EXT:000003676	denotes	β-Actin
T10817	43705-43710	PR_EXT:000009279	denotes	Sam68
T11058	43791-43796	PR_EXT:000009279	denotes	Sam68
T11059	43797-43812	GO_EXT:negative_regulation	denotes	down-regulation
T11060	43843-43848	SO_EXT:0002031	denotes	shRNA
T11061	43853-43857	CHEBI_SO_EXT:base	denotes	base
T11062	43858-43880	CHEBI_SO_EXT:double_stranded_DNA	denotes	duplex DNA nucleotides
T11063	43940-43944	CHEBI_SO_EXT:base	denotes	base
T11064	43945-43953	CHEBI_EXT:residue	denotes	residues
T11065	43966-43971	NCBITaxon:10088	denotes	mouse
T11066	43972-43977	PR_EXT:000009279	denotes	Sam68
T11067	44067-44073	SO_EXT:sequence_cloning_process	denotes	cloned
T11068	44143-44156	GO:0009294	denotes	Transfections
T11069	44215-44221	SO_EXT:sequence_cloning_process	denotes	cloned
T11070	44222-44225	CHEBI_SO_EXT:DNA	denotes	DNA
T11071	44244-44250	SO_EXT:0000440	denotes	vector
T11072	44266-44278	GO:0009294	denotes	transfection
T11073	44320-44329	CHEBI:17939	denotes	puromycin
T11074	44385-44390	PR_EXT:000009279	denotes	Sam68
T11075	44397-44405	GO:0042571	denotes	antibody
T11214	44408-44418	GO:0001503	denotes	Osteogenic
T11215	44419-44434	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T11216	44457-44462	CL_GO_EXT:cell	denotes	cells
T11217	44468-44478	GO:0001503	denotes	osteogenic
T11218	44479-44494	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T11219	44513-44518	CL_GO_EXT:cell	denotes	cells
T11220	44545-44551	UBERON:0000479	denotes	tissue
T11221	44581-44586	CL_GO_EXT:cell	denotes	cells
T11222	44683-44688	PR_EXT:000000164	denotes	BMP-2
T11223	44740-44748	CL_GO_EXT:cell	denotes	cellular
T11224	44749-44752	CHEBI_SO_EXT:RNA	denotes	RNA
T11225	44790-44801	PR_EXT:000030444	denotes	osteocalcin
T11226	44803-44810	PR_EXT:000003676	denotes	β-actin
T11227	44816-44821	GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase	denotes	GAPDH
T11228	44822-44826	SO_EXT:0000704	denotes	gene
T11229	44822-44837	GO:0010467	denotes	gene expression
T11230	44863-44868	PR_EXT:000000164	denotes	BMP-2
T11231	44897-44899	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T6946	28435-28440	GO:0007568	denotes	aging
T7261	33979-33982	PR_EXT:000027234	denotes	Src
T7262	34005-34011	CHEBI_PR_EXT:leptin	denotes	leptin
T7263	34012-34021	GO:0065007	denotes	regulates
T7264	34022-34026	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7265	34022-34037	GO:0045453	denotes	bone resorption
T7266	34068-34094	UBERON:0000013	denotes	sympathetic nervous system
T7267	34111-34122	CL:0000062	denotes	osteoblasts
T7268	34131-34143	GO_PR_EXT:beta_adrenergic_receptor	denotes	β-adrenergic
T7269	34167-34174	GO_EXT:biological_release	denotes	release
T7270	34178-34184	GO_EXT:biological_growth_entity_or_process	denotes	growth
T7271	34178-34192	GO_EXT:0008083	denotes	growth factors
R4101	T7200	T7199	_lexicallyChainedTo	cells,primary
R4102	T7211	T7210	_lexicallyChainedTo	cells,embryonic
R4103	T7214	T7213	_lexicallyChainedTo	cells,mesenchymal
R5770	T9273	T9272	_lexicallyChainedTo	cells,embryonic stem
R5771	T9273	T9274	_lexicallyChainedTo	cells,ES
R335	T868	T867	_lexicallyChainedTo	cells,response of
R336	T900	T899	_lexicallyChainedTo	cells,response of
R337	T963	T962	_lexicallyChainedTo	neurons,formation of
R338	T1024	T1023	_lexicallyChainedTo	cells,differentiation of
R339	T1054	T1053	_lexicallyChainedTo	regeneration,bone
R1153	T2041	T2040	_lexicallyChainedTo	of long bones,epiphysis
R1154	T2043	T2042	_lexicallyChainedTo	of long bones,metaphysis
R1730	T2969	T2968	_lexicallyChainedTo	skeleton,axial
R1731	T3032	T3031	_lexicallyChainedTo	skeleton,axial
R3371	T5544	T5543	_lexicallyChainedTo	differentiation,regulation of
R3372	T5591	T5590	_lexicallyChainedTo	cells,differentiation of
R3373	T5598	T5597	_lexicallyChainedTo	cells,embryonic
R3374	T5601	T5600	_lexicallyChainedTo	cells,mesenchymal
R3375	T5611	T5610	_lexicallyChainedTo	cells,Populations of
R3376	T5678	T5677	_lexicallyChainedTo	cells,differentiation of
R4095	T6948	T6947	_lexicallyChainedTo	cells,differentiation of
R4096	T6951	T6950	_lexicallyChainedTo	cells,bone marrow
R4097	T6960	T6959	_lexicallyChainedTo	cells,embryonic
R4098	T6963	T6962	_lexicallyChainedTo	cells,mesenchymal
R4099	T7179	T7178	_lexicallyChainedTo	cells,differentiation of
R4100	T7181	T7180	_lexicallyChainedTo	cells,primary

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PMC:1315279 / 3043-48409 JSON TXT