PMC:1315279 / 18868-19934 JSONTXT

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The reduction in both osteoblast and osteoclast activity in the 12-month-old Sam68+/+ mice argued against bone being lost primarily due to a relative increase in osteoclast over osteoblast activity, as seen in high turnover disease [49].\nFigure 5 Histologic Analysis of Undecalcified Bone from Sam68+/+ and Sam68−/− Mice\nSections of tibia fixed in 4% paraformaldehyde and embedded in plastic were stained for ALP (A–C, E–G) activity to identify osteoblasts or for TRAP (B–D, F–H) activity to identify osteoclasts. 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