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Quantification of the micro-CT data shown in Figure 3B confirmed the reduction in bone volume compared with tissue volume (BV/TV; Figure 4A, left) in the 12-month-old Sam68+/+ mice (hatched bars) compared with 4-month-old mice of both genotypes (solid bars) and 12-month-old Sam68−/− mice (stippled bars). This was associated with a significant increase (p \u003c 0.01; denoted by the asterisks) in the structure model index, which measures the ratio of plate-like to rod-like structures (Figure 4A, right). A quantifiable increase in the mean trabecular separation (Tb.Sp) (unpublished data) in 12-month-old Sam68+/+ mice was due to an increase in the percentage of spa"}

{"project":"craft-ca-core-dev","denotations":[{"id":"T3532","span":{"begin":35,"end":41},"obj":"NCBITaxon:9606"},{"id":"T3533","span":{"begin":65,"end":75},"obj":"NCBITaxon:1"},{"id":"T3534","span":{"begin":197,"end":203},"obj":"UBERON:0000479"},{"id":"T3535","span":{"begin":256,"end":261},"obj":"PR:000009279"},{"id":"T3536","span":{"begin":265,"end":269},"obj":"NCBITaxon:10088"},{"id":"T3537","span":{"begin":311,"end":315},"obj":"NCBITaxon:10088"},{"id":"T3538","span":{"begin":364,"end":369},"obj":"PR:000009279"},{"id":"T3539","span":{"begin":373,"end":377},"obj":"NCBITaxon:10088"},{"id":"T3540","span":{"begin":693,"end":698},"obj":"PR:000009279"},{"id":"T3541","span":{"begin":702,"end":706},"obj":"NCBITaxon:10088"}],"text":"atures of age-related bone loss in humans that can predispose an individual to fracture. Quantification of the micro-CT data shown in Figure 3B confirmed the reduction in bone volume compared with tissue volume (BV/TV; Figure 4A, left) in the 12-month-old Sam68+/+ mice (hatched bars) compared with 4-month-old mice of both genotypes (solid bars) and 12-month-old Sam68−/− mice (stippled bars). This was associated with a significant increase (p \u003c 0.01; denoted by the asterisks) in the structure model index, which measures the ratio of plate-like to rod-like structures (Figure 4A, right). A quantifiable increase in the mean trabecular separation (Tb.Sp) (unpublished data) in 12-month-old Sam68+/+ mice was due to an increase in the percentage of spa"}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T3558","span":{"begin":22,"end":26},"obj":"UBERON_EXT:bone_element_or_tissue"},{"id":"T3559","span":{"begin":35,"end":41},"obj":"NCBITaxon:9606"},{"id":"T3560","span":{"begin":65,"end":75},"obj":"NCBITaxon:1"},{"id":"T3561","span":{"begin":171,"end":175},"obj":"UBERON_EXT:bone_element_or_tissue"},{"id":"T3562","span":{"begin":197,"end":203},"obj":"UBERON:0000479"},{"id":"T3563","span":{"begin":256,"end":261},"obj":"PR_EXT:000009279"},{"id":"T3564","span":{"begin":261,"end":262},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T3565","span":{"begin":263,"end":264},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T3566","span":{"begin":265,"end":269},"obj":"NCBITaxon:10088"},{"id":"T3567","span":{"begin":311,"end":315},"obj":"NCBITaxon:10088"},{"id":"T3568","span":{"begin":324,"end":333},"obj":"SO_EXT:genotype_or_entity_with_genotype"},{"id":"T3569","span":{"begin":364,"end":369},"obj":"PR_EXT:000009279"},{"id":"T3570","span":{"begin":369,"end":370},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T3571","span":{"begin":371,"end":372},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T3572","span":{"begin":373,"end":377},"obj":"NCBITaxon:10088"},{"id":"T3573","span":{"begin":628,"end":638},"obj":"PATO_UBERON_EXT:trabeculation_entity_or_quality"},{"id":"T3574","span":{"begin":693,"end":698},"obj":"PR_EXT:000009279"},{"id":"T3575","span":{"begin":698,"end":699},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T3576","span":{"begin":700,"end":701},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T3577","span":{"begin":702,"end":706},"obj":"NCBITaxon:10088"}],"text":"atures of age-related bone loss in humans that can predispose an individual to fracture. Quantification of the micro-CT data shown in Figure 3B confirmed the reduction in bone volume compared with tissue volume (BV/TV; Figure 4A, left) in the 12-month-old Sam68+/+ mice (hatched bars) compared with 4-month-old mice of both genotypes (solid bars) and 12-month-old Sam68−/− mice (stippled bars). This was associated with a significant increase (p \u003c 0.01; denoted by the asterisks) in the structure model index, which measures the ratio of plate-like to rod-like structures (Figure 4A, right). A quantifiable increase in the mean trabecular separation (Tb.Sp) (unpublished data) in 12-month-old Sam68+/+ mice was due to an increase in the percentage of spa"}