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PMC:1310901 / 21663-28193 JSONTXT

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bionlp-st-ge-2016-reference-eval

Id Subject Object Predicate Lexical cue
T14439 313-319 Negative_regulation denotes absent
T14440 875-883 Gene_expression denotes negative
T14441 888-896 Gene_expression denotes positive
T14442 967-973 Regulation denotes change
T14443 1052-1058 Regulation denotes affect
T14444 1052-1058 Regulation denotes affect
T14445 1306-1316 Gene_expression denotes expression
T14446 1346-1353 Positive_regulation denotes induced
T14447 1531-1546 Negative_regulation denotes down-regulation
T14448 1556-1566 Gene_expression denotes expression
T14449 1598-1601 Positive_regulation denotes due
T14450 326-336 Gene_expression denotes expression
T14451 1674-1687 Gene_expression denotes re-expression
T14452 1727-1733 Positive_regulation denotes result
T14453 1949-1960 Binding denotes interacting
T14454 2032-2042 Regulation denotes regulation
T14455 2052-2062 Gene_expression denotes expression
T14456 2202-2212 Gene_expression denotes expression
T14457 2393-2400 Positive_regulation denotes account
T14458 2409-2416 Negative_regulation denotes absence
T14459 2426-2436 Gene_expression denotes expression
T14460 2656-2664 Gene_expression denotes positive
T14461 497-501 Negative_regulation denotes lack
T14462 2798-2802 Regulation denotes role
T14463 2806-2816 Regulation denotes regulation
T14464 2826-2836 Gene_expression denotes expression
T14465 2883-2897 Regulation denotes important role
T14466 2907-2916 Positive_regulation denotes induction
T14467 2926-2936 Gene_expression denotes expression
T14468 2937-2944 Positive_regulation denotes depends
T14469 2948-2955 Binding denotes binding
T14470 3097-3105 Negative_regulation denotes inhibits
T14471 3106-3113 Binding denotes binding
T14472 511-521 Gene_expression denotes expression
T14473 3226-3234 Gene_expression denotes positive
T14474 3240-3248 Gene_expression denotes negative
T14475 3335-3344 Negative_regulation denotes silencing
T14476 3433-3445 Regulation denotes deregulation
T14477 3629-3643 Positive_regulation denotes overexpression
T14478 3984-3994 Gene_expression denotes expression
T14479 4235-4245 Gene_expression denotes expression
T14480 4300-4310 Gene_expression denotes expression
T14481 4422-4426 Negative_regulation denotes loss
T14482 4436-4446 Gene_expression denotes expression
T14483 682-693 Positive_regulation denotes responsible
T14484 4652-4662 Gene_expression denotes expression
T14485 4736-4744 Negative_regulation denotes impaired
T14486 4823-4827 Negative_regulation denotes loss
T14487 4853-4861 Negative_regulation denotes reverted
T14488 4871-4879 Gene_expression denotes negative
T14489 4977-4983 Regulation denotes effect
T14490 4993-4999 Gene_expression denotes levels
T14491 5009-5017 Gene_expression denotes positive
T14492 5285-5295 Gene_expression denotes expression
T14493 5296-5303 Regulation denotes changes
T14494 698-704 Negative_regulation denotes absent
T14495 5725-5734 Positive_regulation denotes resulting
T14496 5751-5765 Positive_regulation denotes overexpression
T14497 5812-5822 Gene_expression denotes expression
T14498 6074-6089 Negative_regulation denotes Down-regulation
T14499 6212-6221 Gene_expression denotes knock-out
T14500 6212-6221 Gene_expression denotes knock-out
T14501 6245-6258 Positive_regulation denotes up-regulation
T14502 6379-6388 Regulation denotes regulates
T14503 6395-6405 Gene_expression denotes expression
T14504 6425-6435 Gene_expression denotes expression
T14505 711-721 Gene_expression denotes expression
T14506 6483-6494 Positive_regulation denotes consequence
T14507 777-785 Gene_expression denotes positive
T14508 791-799 Gene_expression denotes negative
T14509 320-325 Protein denotes IRF-4
T14510 1550-1555 Protein denotes IRF-4
T14511 3073-3076 Entity denotes CpG
T14512 3084-3096 Entity denotes NFκB element
T14513 1790-1795 Protein denotes IRF-4
T14514 3358-3366 Entity denotes promoter
T14515 1916-1921 Protein denotes IRF-7
T14516 1935-1939 Protein denotes PU.1
T14517 1972-1977 Protein denotes IRF-4
T14518 2046-2051 Protein denotes IRF-4
T14519 2196-2201 Protein denotes IRF-4
T14520 2295-2300 Protein denotes IRF-4
T14521 2420-2425 Protein denotes IRF-4
T14522 2650-2655 Protein denotes IRF-4
T14523 455-460 Protein denotes IRF-4
T14524 2688-2693 Protein denotes IRF-4
T14525 2820-2825 Protein denotes IRF-4
T14526 2901-2906 Protein denotes IRF-4
T14527 2920-2925 Protein denotes IRF-4
T14528 2978-2983 Protein denotes c-Rel
T14529 3009-3014 Protein denotes IRF-4
T14530 3220-3225 Protein denotes IRF-4
T14531 3352-3357 Protein denotes IRF-4
T14532 3427-3432 Protein denotes IRF-4
T14533 3647-3652 Protein denotes DNMT1
T14534 505-510 Protein denotes IRF-4
T14535 3978-3983 Protein denotes DNMT1
T14536 4026-4034 Protein denotes p15INK4b
T14537 4229-4234 Protein denotes IRF-4
T14538 4294-4299 Protein denotes IRF-4
T14539 4430-4435 Protein denotes IRF-4
T14540 4679-4717 Protein denotes IFN consensus sequence binding protein
T14541 4719-4724 Protein denotes ICSBP
T14542 4725-4730 Protein denotes IRF-8
T14543 4812-4817 Protein denotes IRF-4
T14544 4865-4870 Protein denotes ICSBP
T14545 705-710 Protein denotes IRF-4
T14546 4987-4992 Protein denotes ICSBP
T14547 5003-5008 Protein denotes ICSBP
T14548 5113-5118 Protein denotes IRF-4
T14549 5175-5183 Protein denotes p15INK4b
T14550 5185-5193 Protein denotes p16INK4a
T14551 5197-5200 Protein denotes p53
T14552 5419-5424 Protein denotes IRF-4
T14553 5481-5486 Protein denotes IRF-4
T14554 5529-5534 Protein denotes IRF-4
T14555 5682-5708 Protein denotes immunoglobulin heavy-chain
T14556 771-776 Protein denotes IRF-4
T14557 5710-5713 Protein denotes IgH
T14558 5719-5724 Protein denotes IRF-4
T14559 5769-5774 Protein denotes IRF-4
T14560 5806-5811 Protein denotes IRF-4
T14561 6067-6072 Protein denotes IRF-4
T14562 6093-6098 Protein denotes IRF-4
T14563 6187-6192 Protein denotes IRF-4
T14564 6196-6201 Protein denotes ICSBP
T14565 6239-6244 Protein denotes IRF-4
T14566 6352-6357 Protein denotes IRF-4
T14567 869-874 Protein denotes IRF-4
T14568 6389-6394 Protein denotes IRF-4
T14569 6439-6444 Protein denotes IRF-4
T14570 6498-6503 Protein denotes IRF-4
T14571 1170-1175 Protein denotes IRF-4
T14572 993-1027 Entity denotes transcription factor binding sites
T14573 1063-1080 Entity denotes restriction sites
T14574 1300-1305 Protein denotes IRF-4
T14575 1084-1104 Entity denotes primer binding sites
T14576 1386-1391 Protein denotes IFN-α
T14577 2861-2874 Entity denotes NFκB elements
R11906 T14445 T14446 themeOf expression,induced
R11907 T14447 T14449 themeOf down-regulation,due
R11908 T14448 T14447 themeOf expression,down-regulation
R11909 T14450 T14439 themeOf expression,absent
R11910 T14451 T14452 themeOf re-expression,result
R11912 T14455 T14454 themeOf expression,regulation
R11913 T14458 T14457 themeOf absence,account
R11914 T14459 T14458 themeOf expression,absence
R11915 T14463 T14462 themeOf regulation,role
R11917 T14464 T14463 themeOf expression,regulation
R11918 T14466 T14465 themeOf induction,important role
R11920 T14467 T14468 themeOf expression,depends
R11921 T14469 T14468 causeOf binding,depends
R11923 T14471 T14470 themeOf binding,inhibits
R11926 T14472 T14461 themeOf expression,lack
R11929 T14482 T14481 themeOf expression,loss
R11930 T14484 T14485 themeOf expression,impaired
R11932 T14486 T14487 themeOf loss,reverted
R11933 T14516 T14453 themeOf PU.1,interacting
R11934 T14490 T14489 themeOf levels,effect
R11935 T14492 T14493 themeOf expression,changes
R11936 T14494 T14483 themeOf absent,responsible
R11937 T14517 T14453 themeOf IRF-4,interacting
R11938 T14496 T14495 themeOf overexpression,resulting
R11939 T14518 T14455 themeOf IRF-4,expression
R11940 T14519 T14456 themeOf IRF-4,expression
R11941 T14503 T14502 themeOf expression,regulates
R11942 T14521 T14459 themeOf IRF-4,expression
R11943 T14504 T14506 themeOf expression,consequence
R11944 T14505 T14494 themeOf expression,absent
R11945 T14522 T14460 themeOf IRF-4,positive
R11946 T14509 T14450 themeOf IRF-4,expression
R11947 T14525 T14464 themeOf IRF-4,expression
R11948 T14526 T14466 themeOf IRF-4,induction
R11949 T14527 T14467 themeOf IRF-4,expression
R11950 T14510 T14448 themeOf IRF-4,expression
R11951 T14510 T14451 themeOf IRF-4,re-expression
R11952 T14511 T14470 causeOf CpG,inhibits
R11953 T14511 T14529 partOf CpG,IRF-4
R11954 T14528 T14469 themeOf c-Rel,binding
R11955 T14512 T14471 themeOf NFκB element,binding
R11956 T14512 T14529 partOf NFκB element,IRF-4
R11957 T14514 T14475 themeOf promoter,silencing
R11958 T14514 T14531 partOf promoter,IRF-4
R11959 T14530 T14473 themeOf IRF-4,positive
R11960 T14530 T14474 themeOf IRF-4,negative
R11961 T14532 T14476 themeOf IRF-4,deregulation
R11962 T14545 T14505 themeOf IRF-4,expression
R11963 T14546 T14490 themeOf ICSBP,levels
R11964 T14533 T14477 themeOf DNMT1,overexpression
R11965 T14547 T14491 themeOf ICSBP,positive
R11966 T14548 T14492 themeOf IRF-4,expression
R11967 T14534 T14472 themeOf IRF-4,expression
R11968 T14535 T14478 themeOf DNMT1,expression
R11969 T14537 T14479 themeOf IRF-4,expression
R11970 T14556 T14507 themeOf IRF-4,positive
R11971 T14556 T14508 themeOf IRF-4,negative
R11972 T14557 T14555 equivalentTo IgH,immunoglobulin heavy-chain
R11973 T14538 T14480 themeOf IRF-4,expression
R11974 T14559 T14496 themeOf IRF-4,overexpression
R11975 T14560 T14497 themeOf IRF-4,expression
R11976 T14539 T14482 themeOf IRF-4,expression
R11977 T14562 T14498 themeOf IRF-4,Down-regulation
R11978 T14540 T14484 themeOf IFN consensus sequence binding protein,expression
R11979 T14563 T14499 themeOf IRF-4,knock-out
R11980 T14564 T14500 themeOf ICSBP,knock-out
R11981 T14565 T14501 themeOf IRF-4,up-regulation
R11982 T14567 T14440 themeOf IRF-4,negative
R11983 T14567 T14441 themeOf IRF-4,positive
R11984 T14568 T14503 themeOf IRF-4,expression
R11985 T14540 T14486 themeOf IFN consensus sequence binding protein,loss
R11986 T14569 T14504 themeOf IRF-4,expression
R11987 T14541 T14540 equivalentTo ICSBP,IFN consensus sequence binding protein
R11988 T14572 T14442 themeOf transcription factor binding sites,change
R11989 T14572 T14545 partOf transcription factor binding sites,IRF-4
R11990 T14573 T14545 partOf restriction sites,IRF-4
R11991 T14573 T14444 themeOf restriction sites,affect
R11992 T14542 T14540 equivalentTo IRF-8,IFN consensus sequence binding protein
R11993 T14574 T14445 themeOf IRF-4,expression
R11994 T14575 T14545 partOf primer binding sites,IRF-4
R11995 T14575 T14443 themeOf primer binding sites,affect
R11996 T14576 T14446 causeOf IFN-α,induced
R11997 T14544 T14488 themeOf ICSBP,negative
R11998 T14577 T14465 causeOf NFκB elements,important role
R11999 T14577 T14529 partOf NFκB elements,IRF-4
R12000 T14577 T14469 themeOf NFκB elements,binding

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T14173 313-319 Negative_regulation denotes absent
T14174 320-325 Protein denotes IRF-4
T14175 326-336 Gene_expression denotes expression
T14176 455-460 Protein denotes IRF-4
T14177 497-501 Negative_regulation denotes lack
T14178 505-510 Protein denotes IRF-4
T14179 511-521 Gene_expression denotes expression
T14180 682-693 Positive_regulation denotes responsible true
T14181 698-704 Negative_regulation denotes absent
T14182 705-710 Protein denotes IRF-4
T14183 711-721 Gene_expression denotes expression
T14184 771-776 Protein denotes IRF-4
T14185 777-785 Gene_expression denotes positive
T14186 791-799 Gene_expression denotes negative true
T14187 869-874 Protein denotes IRF-4
T14188 875-883 Gene_expression denotes negative true
T14189 888-896 Gene_expression denotes positive
T14190 967-973 Regulation denotes change true
T14191 993-1027 Entity denotes transcription factor binding sites
T14192 1052-1058 Regulation denotes affect true
T14193 1052-1058 Regulation denotes affect true
T14194 1063-1080 Entity denotes restriction sites
T14195 1084-1104 Entity denotes primer binding sites
T14196 1170-1175 Protein denotes IRF-4
T14197 1300-1305 Protein denotes IRF-4
T14198 1306-1316 Gene_expression denotes expression
T14199 1346-1353 Positive_regulation denotes induced
T14200 1386-1391 Protein denotes IFN-α
T14201 1531-1546 Negative_regulation denotes down-regulation
T14202 1550-1555 Protein denotes IRF-4
T14203 1556-1566 Gene_expression denotes expression
T14204 1598-1601 Positive_regulation denotes due true
T14205 1674-1687 Gene_expression denotes re-expression
T14206 1727-1733 Positive_regulation denotes result true
T14207 1790-1795 Protein denotes IRF-4
T14208 1916-1921 Protein denotes IRF-7
T14209 1935-1939 Protein denotes PU.1
T14210 1949-1960 Binding denotes interacting
T14211 1972-1977 Protein denotes IRF-4
T14212 2032-2042 Regulation denotes regulation
T14213 2046-2051 Protein denotes IRF-4
T14214 2052-2062 Gene_expression denotes expression
T14215 2196-2201 Protein denotes IRF-4
T14216 2202-2212 Gene_expression denotes expression
T14217 2295-2300 Protein denotes IRF-4
T14218 2393-2400 Positive_regulation denotes account true
T14219 2409-2416 Negative_regulation denotes absence
T14220 2420-2425 Protein denotes IRF-4
T14221 2426-2436 Gene_expression denotes expression
T14222 2650-2655 Protein denotes IRF-4
T14223 2656-2664 Gene_expression denotes positive
T14224 2688-2693 Protein denotes IRF-4
T14225 2798-2802 Regulation denotes role true
T14226 2806-2816 Regulation denotes regulation
T14227 2820-2825 Protein denotes IRF-4
T14228 2826-2836 Gene_expression denotes expression
T14229 2861-2874 Entity denotes NFκB elements
T14230 2883-2897 Regulation denotes important role
T14231 2901-2906 Protein denotes IRF-4
T14232 2907-2916 Positive_regulation denotes induction
T14233 2920-2925 Protein denotes IRF-4
T14234 2926-2936 Gene_expression denotes expression
T14235 2937-2944 Positive_regulation denotes depends
T14236 2948-2955 Binding denotes binding
T14237 2978-2983 Protein denotes c-Rel
T14238 3009-3014 Protein denotes IRF-4
T14239 3073-3076 Entity denotes CpG
T14240 3084-3096 Entity denotes NFκB element
T14241 3097-3105 Negative_regulation denotes inhibits
T14242 3106-3113 Binding denotes binding
T14243 3220-3225 Protein denotes IRF-4
T14244 3226-3234 Gene_expression denotes positive
T14245 3240-3248 Gene_expression denotes negative true
T14246 3335-3344 Negative_regulation denotes silencing
T14247 3352-3357 Protein denotes IRF-4
T14248 3358-3366 Entity denotes promoter
T14249 3427-3432 Protein denotes IRF-4
T14250 3433-3445 Regulation denotes deregulation true
T14251 3629-3643 Positive_regulation denotes overexpression
T14252 3647-3652 Protein denotes DNMT1
T14253 3978-3983 Protein denotes DNMT1
T14254 3984-3994 Gene_expression denotes expression
T14255 4026-4034 Protein denotes p15INK4b
T14256 4229-4234 Protein denotes IRF-4
T14257 4235-4245 Gene_expression denotes expression
T14258 4294-4299 Protein denotes IRF-4
T14259 4300-4310 Gene_expression denotes expression
T14260 4422-4426 Negative_regulation denotes loss
T14261 4430-4435 Protein denotes IRF-4
T14262 4436-4446 Gene_expression denotes expression
T14263 4652-4662 Gene_expression denotes expression
T14264 4679-4717 Protein denotes IFN consensus sequence binding protein
T14265 4719-4724 Protein denotes ICSBP
T14266 4725-4730 Protein denotes IRF-8
T14267 4736-4744 Negative_regulation denotes impaired
T14268 4812-4817 Protein denotes IRF-4
T14269 4823-4827 Negative_regulation denotes loss
T14270 4853-4861 Negative_regulation denotes reverted true
T14271 4865-4870 Protein denotes ICSBP
T14272 4871-4879 Gene_expression denotes negative true
T14273 4977-4983 Regulation denotes effect true
T14274 4987-4992 Protein denotes ICSBP
T14275 4993-4999 Gene_expression denotes levels
T14276 5003-5008 Protein denotes ICSBP
T14277 5009-5017 Gene_expression denotes positive
T14278 5113-5118 Protein denotes IRF-4
T14279 5175-5183 Protein denotes p15INK4b
T14280 5185-5193 Protein denotes p16INK4a
T14281 5197-5200 Protein denotes p53
T14282 5285-5295 Gene_expression denotes expression
T14283 5296-5303 Regulation denotes changes
T14284 5419-5424 Protein denotes IRF-4
T14285 5481-5486 Protein denotes IRF-4
T14286 5529-5534 Protein denotes IRF-4
T14287 5682-5708 Protein denotes immunoglobulin heavy-chain
T14288 5710-5713 Protein denotes IgH
T14289 5719-5724 Protein denotes IRF-4
T14290 5725-5734 Positive_regulation denotes resulting
T14291 5751-5765 Positive_regulation denotes overexpression
T14292 5769-5774 Protein denotes IRF-4
T14293 5806-5811 Protein denotes IRF-4
T14294 5812-5822 Gene_expression denotes expression
T14295 6067-6072 Protein denotes IRF-4
T14296 6074-6089 Negative_regulation denotes Down-regulation
T14297 6093-6098 Protein denotes IRF-4
T14298 6187-6192 Protein denotes IRF-4
T14299 6196-6201 Protein denotes ICSBP
T14300 6212-6221 Gene_expression denotes knock-out true
T14301 6212-6221 Gene_expression denotes knock-out true
T14302 6239-6244 Protein denotes IRF-4
T14303 6245-6258 Positive_regulation denotes up-regulation
T14304 6352-6357 Protein denotes IRF-4
T14305 6379-6388 Regulation denotes regulates true
T14306 6389-6394 Protein denotes IRF-4
T14307 6395-6405 Gene_expression denotes expression
T14308 6425-6435 Gene_expression denotes expression
T14309 6439-6444 Protein denotes IRF-4
T14310 6483-6494 Positive_regulation denotes consequence true
T14311 6498-6503 Protein denotes IRF-4
R11754 T14174 T14175 themeOf IRF-4,expression
R11756 T14175 T14173 themeOf expression,absent
R11757 T14178 T14179 themeOf IRF-4,expression
R11758 T14179 T14177 themeOf expression,lack
R11760 T14181 T14180 themeOf absent,responsible
R11761 T14182 T14183 themeOf IRF-4,expression
R11762 T14183 T14181 themeOf expression,absent
R11766 T14184 T14185 themeOf IRF-4,positive
R11767 T14184 T14186 themeOf IRF-4,negative
R11768 T14187 T14188 themeOf IRF-4,negative
R11769 T14187 T14189 themeOf IRF-4,positive
R11772 T14191 T14190 themeOf transcription factor binding sites,change
R11773 T14191 T14182 partOf transcription factor binding sites,IRF-4
R11775 T14194 T14192 themeOf restriction sites,affect
R11776 T14194 T14182 partOf restriction sites,IRF-4
R11777 T14195 T14193 themeOf primer binding sites,affect
R11778 T14195 T14182 partOf primer binding sites,IRF-4
R11779 T14197 T14198 themeOf IRF-4,expression
R11780 T14198 T14199 themeOf expression,induced
R11781 T14200 T14199 causeOf IFN-α,induced
R11782 T14201 T14204 themeOf down-regulation,due
R11783 T14202 T14203 themeOf IRF-4,expression
R11784 T14202 T14205 themeOf IRF-4,re-expression
R11786 T14203 T14201 themeOf expression,down-regulation
R11787 T14205 T14206 themeOf re-expression,result
R11789 T14209 T14210 themeOf PU.1,interacting
R11790 T14211 T14210 themeOf IRF-4,interacting
R11792 T14213 T14214 themeOf IRF-4,expression
R11794 T14214 T14212 themeOf expression,regulation
R11795 T14215 T14216 themeOf IRF-4,expression
R11796 T14264 T14263 themeOf IFN consensus sequence binding protein,expression
R11797 T14219 T14218 themeOf absence,account
R11798 T14220 T14221 themeOf IRF-4,expression
R11799 T14221 T14219 themeOf expression,absence
R11800 T14222 T14223 themeOf IRF-4,positive
R11801 T14264 T14269 themeOf IFN consensus sequence binding protein,loss
R11802 T14265 T14264 equivalentTo ICSBP,IFN consensus sequence binding protein
R11803 T14266 T14264 equivalentTo IRF-8,IFN consensus sequence binding protein
R11804 T14226 T14225 themeOf regulation,role
R11805 T14227 T14228 themeOf IRF-4,expression
R11806 T14228 T14226 themeOf expression,regulation
R11807 T14269 T14270 themeOf loss,reverted
R11808 T14229 T14230 causeOf NFκB elements,important role
R11809 T14229 T14238 partOf NFκB elements,IRF-4
R11810 T14229 T14236 themeOf NFκB elements,binding
R11811 T14231 T14232 themeOf IRF-4,induction
R11812 T14232 T14230 themeOf induction,important role
R11813 T14233 T14234 themeOf IRF-4,expression
R11814 T14234 T14235 themeOf expression,depends
R11815 T14271 T14272 themeOf ICSBP,negative
R11816 T14236 T14235 causeOf binding,depends
R11817 T14237 T14236 themeOf c-Rel,binding
R11818 T14274 T14275 themeOf ICSBP,levels
R11819 T14239 T14241 causeOf CpG,inhibits
R11820 T14239 T14238 partOf CpG,IRF-4
R11821 T14240 T14242 themeOf NFκB element,binding
R11822 T14240 T14238 partOf NFκB element,IRF-4
R11823 T14242 T14241 themeOf binding,inhibits
R11824 T14243 T14244 themeOf IRF-4,positive
R11825 T14243 T14245 themeOf IRF-4,negative
R11826 T14275 T14273 themeOf levels,effect
R11827 T14276 T14277 themeOf ICSBP,positive
R11828 T14248 T14246 themeOf promoter,silencing
R11829 T14248 T14247 partOf promoter,IRF-4
R11830 T14249 T14250 themeOf IRF-4,deregulation
R11831 T14252 T14251 themeOf DNMT1,overexpression
R11832 T14278 T14282 themeOf IRF-4,expression
R11833 T14253 T14254 themeOf DNMT1,expression
R11834 T14256 T14257 themeOf IRF-4,expression
R11835 T14282 T14283 themeOf expression,changes
R11836 T14258 T14259 themeOf IRF-4,expression
R11837 T14261 T14262 themeOf IRF-4,expression
R11838 T14262 T14260 themeOf expression,loss
R11839 T14263 T14267 themeOf expression,impaired
R11840 T14288 T14287 equivalentTo IgH,immunoglobulin heavy-chain
R11841 T14291 T14290 themeOf overexpression,resulting
R11842 T14292 T14291 themeOf IRF-4,overexpression
R11843 T14293 T14294 themeOf IRF-4,expression
R11844 T14297 T14296 themeOf IRF-4,Down-regulation
R11845 T14298 T14301 themeOf IRF-4,knock-out
R11846 T14299 T14300 themeOf ICSBP,knock-out
R11848 T14302 T14303 themeOf IRF-4,up-regulation
R11851 T14306 T14307 themeOf IRF-4,expression
R11855 T14307 T14305 themeOf expression,regulates
R11859 T14308 T14310 themeOf expression,consequence
R11861 T14309 T14308 themeOf IRF-4,expression

GO-CC

Id Subject Object Predicate Lexical cue
T13739 349-354 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13740 800-805 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13741 897-902 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13742 2081-2086 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13743 2455-2460 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13744 2703-2708 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13745 3249-3254 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13746 3741-3746 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13747 3828-3833 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13748 3920-3925 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13749 4270-4275 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13750 5024-5029 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13751 5906-5910 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13752 5989-5993 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13753 6137-6141 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13754 3126-3143 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complexes
T13755 5626-5636 http://purl.obolibrary.org/obo/GO_0005694 denotes chromosome

sentences

Id Subject Object Predicate Lexical cue
T11278 11-97 Sentence denotes Many genetic lesions are known to influence gene expression of tumor suppressor genes.
T11279 98-280 Sentence denotes Whereas mutations and deletions or insertions have permanent effects, reversible mechanisms are gene methylation, or expression and activation of transcription factors, respectively.
T11280 281-412 Sentence denotes We studied a putative cause for absent IRF-4 expression in leukemia cells and first focused on genetic aberrations of the promoter.
T11281 413-522 Sentence denotes We observed no genetic alterations in the IRF-4 promoter, which can account for the lack of IRF-4 expression:
T11282 523-934 Sentence denotes The detected base pair changes at position −1081 (T→C substitution), at position −1068 (A→C substitution) and at position −116 (A→C substitution) are unlikely responsible for absent IRF-4-expression since the first two mutations were found both in IRF-4-positive and -negative cells whereas the latter change was not detected consistently in all IRF-4-negative or -positive cells and may thus be a polymorphism.
T11283 935-1124 Sentence denotes All three substitutions did not change any known putative transcription factor binding sites (30,31) and also do not affect any restriction sites or primer binding sites of the used assays.
T11284 1125-1293 Sentence denotes However, permanent genetic variations in the IRF-4 coding sequence, such as deletions or mutations resulting in stop-codons have not been excluded by sequence analysis.
T11285 1294-1476 Sentence denotes Since IRF-4 expression in cell lines and CML can be induced by demethylation and successful IFN-α therapy (3), respectively, the existence of such genetic aberrations seems unlikely.
T11286 1477-1796 Sentence denotes We then investigated whether the previously described down-regulation of IRF-4 expression in human myeloid leukemias was due to a differential hypermethylation of the promoter, since the presented re-expression due to AzadC-treatment might also be a result of activation of positive transcriptional regulators of IRF-4.
T11287 1797-1978 Sentence denotes Methylation of CpG sites is a common mechanism of silencing genes in leukemia and has also been shown for another IRF, IRF-7 (35) and for PU.1 (36), an interacting partner of IRF-4.
T11288 1979-2181 Sentence denotes To elucidate the relevance of this mechanism for the regulation of IRF-4 expression, various leukemic cells were treated with demethylating agents and promoters were sequenced after bisulfite treatment.
T11289 2182-2310 Sentence denotes We found that IRF-4 expression could indeed be connected to the methylation status of distinct CpG motifs in the IRF-4 promoter.
T11290 2311-2461 Sentence denotes In Figure 4A, those CpG sites are shown (bottom line), whose hypermethylation may account for the absence of IRF-4 expression in the respective cells.
T11291 2462-2588 Sentence denotes One of them (#54) is adjacent to an identified regulatory element (NFκB-site), indicating a possible involvement of this site.
T11292 2589-2709 Sentence denotes At two further CpG sites (#48, 45) the methylation status in IRF-4-positive was lower than that of IRF-4-negative cells.
T11293 2710-2837 Sentence denotes These CpG sites are located in an NFκB and an SP1 element (31) and thus may also play a role in regulation of IRF-4 expression.
T11294 2838-3032 Sentence denotes It has been shown that NFκB elements play an important role in IRF-4 induction as IRF-4 expression depends on binding of the transactivator c-Rel to these elements in the IRF-4 promoter (31,37).
T11295 3033-3255 Sentence denotes Furthermore, methylation of the central CpG in the NFκB element inhibits binding of the NFκB protein complexes (38), promoting the significance of the observed methylation differences in IRF-4-positive and -negative cells.
T11296 3256-3454 Sentence denotes Via in vitro methylation and reporter gene assays we could clearly appoint the silencing of the IRF-4 promoter to a methylation effect, which may thus be the mechanism of IRF-4 deregulation in vivo.
T11297 3455-3583 Sentence denotes One possible cause for the aberrant methylation in tumorigenesis is an increased level of DNMTs during the pathogenetic process.
T11298 3584-3700 Sentence denotes In colon, lung and hematologic malignancies, overexpression of DNMT1, a maintenance DNMT, has been detected (39–41).
T11299 3701-3931 Sentence denotes Furthermore, it has been shown that CML cells in the acute phase exhibited elevated levels of the three known DNMTs, while CML cells in chronic phase expressed normal levels of DNMTs if compared with normal bone marrow cells (25).
T11300 3932-4065 Sentence denotes Interestingly, a positive correlation between DNMT1 expression levels and hypermethylation of p15INK4b has been detected in AML (25).
T11301 4066-4276 Sentence denotes In this work, we did not detect significant mRNA expression differences of selected DNMT or MBP, making it an unlikely cause for the observed methylation and thus IRF-4 expression differences in leukemia cells.
T11302 4277-4454 Sentence denotes The finding that IRF-4 expression is silenced by promoter hypermethylation might represent a mechanism that accounts for the previously observed loss of IRF-4 expression in CML.
T11303 4455-4647 Sentence denotes Indeed, several clinical trials with leukemia patients and patients with myelodysplastic syndromes demonstrated the potential clinical benefit of a treatment with demethylating agents (42–45).
T11304 4648-4792 Sentence denotes The expression of another IRF, IFN consensus sequence binding protein (ICSBP/IRF-8), is impaired in myeloid leukemias especially CML (27,46,47).
T11305 4793-5041 Sentence denotes But in contrast to IRF-4, the loss of this IRF could not be reverted in ICSBP-negative cell lines (EM-2, CML-T1, K-562 and LAMA-84) by treatment with AzadC (Figure 6) and AzadC has no effect on ICSBP levels in ICSBP-positive U-937 cells (Figure 6).
T11306 5042-5112 Sentence denotes These data suggest a distinct regulatory mechanism for these two IRFs.
T11307 5113-5375 Sentence denotes IRF-4, similar to many other classical tumor suppressor genes p15INK4b, p16INK4a or p53, may thus be a subject of alterations in the promoter methylation status leading to expression changes, which might contribute to the initiation and/or progression of cancer.
T11308 5376-5515 Sentence denotes Still, the obvious functional diversity of IRF-4 remains remarkable and cannot be fully explained by the IRF-4 promoter methylation status.
T11309 5516-5581 Sentence denotes For example, IRF-4 is primarily known for its oncogenic features.
T11310 5582-5783 Sentence denotes In multiple myeloma (MM) a translocation on chromosome 14q was reported to lead to a fusion gene of immunoglobulin heavy-chain (IgH) and IRF-4 resulting in a subsequent overexpression of IRF-4 (48,49).
T11311 5784-6017 Sentence denotes In addition, abundant IRF-4 expression was found to be a marker for various subsets of lymphomas, such as diffuse large B-cell lymphomas, primary effusion lymphoma, and marginal zone lymphoma, and adult T-cell leukemia (11,31,50–52).
T11312 6018-6073 Sentence denotes This draws a more complex picture of the role of IRF-4.
T11313 6074-6313 Sentence denotes Down-regulation of IRF-4 may promote leukemogenesis in myeloid cell context (3), which was recently confirmed in IRF-4−/− ICSBP−/− double knock-out mice (53), while IRF-4 up-regulation may induce a growth advantage in lymphomas or MM (48).
T11314 6314-6530 Sentence denotes Taken together, our data suggest that IRF-4 promoter methylation regulates IRF-4 expression, and that aberrant expression of IRF-4 in certain types of leukemia may be a consequence of IRF-4 promoter hypermethylation.
T153 0-10 Sentence denotes DISCUSSION
T154 11-97 Sentence denotes Many genetic lesions are known to influence gene expression of tumor suppressor genes.
T155 98-280 Sentence denotes Whereas mutations and deletions or insertions have permanent effects, reversible mechanisms are gene methylation, or expression and activation of transcription factors, respectively.
T156 281-412 Sentence denotes We studied a putative cause for absent IRF-4 expression in leukemia cells and first focused on genetic aberrations of the promoter.
T157 413-522 Sentence denotes We observed no genetic alterations in the IRF-4 promoter, which can account for the lack of IRF-4 expression:
T158 523-934 Sentence denotes The detected base pair changes at position −1081 (T→C substitution), at position −1068 (A→C substitution) and at position −116 (A→C substitution) are unlikely responsible for absent IRF-4-expression since the first two mutations were found both in IRF-4-positive and -negative cells whereas the latter change was not detected consistently in all IRF-4-negative or -positive cells and may thus be a polymorphism.
T159 935-1124 Sentence denotes All three substitutions did not change any known putative transcription factor binding sites (30,31) and also do not affect any restriction sites or primer binding sites of the used assays.
T160 1125-1293 Sentence denotes However, permanent genetic variations in the IRF-4 coding sequence, such as deletions or mutations resulting in stop-codons have not been excluded by sequence analysis.
T161 1294-1476 Sentence denotes Since IRF-4 expression in cell lines and CML can be induced by demethylation and successful IFN-α therapy (3), respectively, the existence of such genetic aberrations seems unlikely.
T162 1477-1796 Sentence denotes We then investigated whether the previously described down-regulation of IRF-4 expression in human myeloid leukemias was due to a differential hypermethylation of the promoter, since the presented re-expression due to AzadC-treatment might also be a result of activation of positive transcriptional regulators of IRF-4.
T163 1797-1978 Sentence denotes Methylation of CpG sites is a common mechanism of silencing genes in leukemia and has also been shown for another IRF, IRF-7 (35) and for PU.1 (36), an interacting partner of IRF-4.
T164 1979-2181 Sentence denotes To elucidate the relevance of this mechanism for the regulation of IRF-4 expression, various leukemic cells were treated with demethylating agents and promoters were sequenced after bisulfite treatment.
T165 2182-2310 Sentence denotes We found that IRF-4 expression could indeed be connected to the methylation status of distinct CpG motifs in the IRF-4 promoter.
T166 2311-2461 Sentence denotes In Figure 4A, those CpG sites are shown (bottom line), whose hypermethylation may account for the absence of IRF-4 expression in the respective cells.
T167 2462-2588 Sentence denotes One of them (#54) is adjacent to an identified regulatory element (NFκB-site), indicating a possible involvement of this site.
T168 2589-2709 Sentence denotes At two further CpG sites (#48, 45) the methylation status in IRF-4-positive was lower than that of IRF-4-negative cells.
T169 2710-2837 Sentence denotes These CpG sites are located in an NFκB and an SP1 element (31) and thus may also play a role in regulation of IRF-4 expression.
T170 2838-3032 Sentence denotes It has been shown that NFκB elements play an important role in IRF-4 induction as IRF-4 expression depends on binding of the transactivator c-Rel to these elements in the IRF-4 promoter (31,37).
T171 3033-3255 Sentence denotes Furthermore, methylation of the central CpG in the NFκB element inhibits binding of the NFκB protein complexes (38), promoting the significance of the observed methylation differences in IRF-4-positive and -negative cells.
T172 3256-3454 Sentence denotes Via in vitro methylation and reporter gene assays we could clearly appoint the silencing of the IRF-4 promoter to a methylation effect, which may thus be the mechanism of IRF-4 deregulation in vivo.
T173 3455-3583 Sentence denotes One possible cause for the aberrant methylation in tumorigenesis is an increased level of DNMTs during the pathogenetic process.
T174 3584-3700 Sentence denotes In colon, lung and hematologic malignancies, overexpression of DNMT1, a maintenance DNMT, has been detected (39–41).
T175 3701-3931 Sentence denotes Furthermore, it has been shown that CML cells in the acute phase exhibited elevated levels of the three known DNMTs, while CML cells in chronic phase expressed normal levels of DNMTs if compared with normal bone marrow cells (25).
T176 3932-4065 Sentence denotes Interestingly, a positive correlation between DNMT1 expression levels and hypermethylation of p15INK4b has been detected in AML (25).
T177 4066-4276 Sentence denotes In this work, we did not detect significant mRNA expression differences of selected DNMT or MBP, making it an unlikely cause for the observed methylation and thus IRF-4 expression differences in leukemia cells.
T178 4277-4454 Sentence denotes The finding that IRF-4 expression is silenced by promoter hypermethylation might represent a mechanism that accounts for the previously observed loss of IRF-4 expression in CML.
T179 4455-4647 Sentence denotes Indeed, several clinical trials with leukemia patients and patients with myelodysplastic syndromes demonstrated the potential clinical benefit of a treatment with demethylating agents (42–45).
T180 4648-4792 Sentence denotes The expression of another IRF, IFN consensus sequence binding protein (ICSBP/IRF-8), is impaired in myeloid leukemias especially CML (27,46,47).
T181 4793-5041 Sentence denotes But in contrast to IRF-4, the loss of this IRF could not be reverted in ICSBP-negative cell lines (EM-2, CML-T1, K-562 and LAMA-84) by treatment with AzadC (Figure 6) and AzadC has no effect on ICSBP levels in ICSBP-positive U-937 cells (Figure 6).
T182 5042-5112 Sentence denotes These data suggest a distinct regulatory mechanism for these two IRFs.
T183 5113-5375 Sentence denotes IRF-4, similar to many other classical tumor suppressor genes p15INK4b, p16INK4a or p53, may thus be a subject of alterations in the promoter methylation status leading to expression changes, which might contribute to the initiation and/or progression of cancer.
T184 5376-5515 Sentence denotes Still, the obvious functional diversity of IRF-4 remains remarkable and cannot be fully explained by the IRF-4 promoter methylation status.
T185 5516-5581 Sentence denotes For example, IRF-4 is primarily known for its oncogenic features.
T186 5582-5783 Sentence denotes In multiple myeloma (MM) a translocation on chromosome 14q was reported to lead to a fusion gene of immunoglobulin heavy-chain (IgH) and IRF-4 resulting in a subsequent overexpression of IRF-4 (48,49).
T187 5784-6017 Sentence denotes In addition, abundant IRF-4 expression was found to be a marker for various subsets of lymphomas, such as diffuse large B-cell lymphomas, primary effusion lymphoma, and marginal zone lymphoma, and adult T-cell leukemia (11,31,50–52).
T188 6018-6073 Sentence denotes This draws a more complex picture of the role of IRF-4.
T189 6074-6313 Sentence denotes Down-regulation of IRF-4 may promote leukemogenesis in myeloid cell context (3), which was recently confirmed in IRF-4−/− ICSBP−/− double knock-out mice (53), while IRF-4 up-regulation may induce a growth advantage in lymphomas or MM (48).
T190 6314-6530 Sentence denotes Taken together, our data suggest that IRF-4 promoter methylation regulates IRF-4 expression, and that aberrant expression of IRF-4 in certain types of leukemia may be a consequence of IRF-4 promoter hypermethylation.

2_test

Id Subject Object Predicate Lexical cue
16396836-8921401-76538201 1029-1031 8921401 denotes 30
16396836-12218129-76538202 1032-1034 12218129 denotes 31
16396836-11013272-76538203 1401-1402 11013272 denotes 3
16396836-10924517-76538204 1923-1925 10924517 denotes 35
16396836-10619599-76538205 1941-1943 10619599 denotes 36
16396836-12218129-76538206 2769-2771 12218129 denotes 31
16396836-12218129-76538207 3025-3027 12218129 denotes 31
16396836-10770796-76538208 3028-3030 10770796 denotes 37
16396836-1768651-76538209 3145-3147 1768651 denotes 38
16396836-8331684-76538210 3693-3695 8331684 denotes 39
16396836-8633014-76538210 3693-3695 8633014 denotes 39
16396836-9529124-76538210 3693-3695 9529124 denotes 39
16396836-11222358-76538211 3927-3929 11222358 denotes 25
16396836-11222358-76538212 4061-4063 11222358 denotes 25
16396836-11281740-76538213 4640-4642 11281740 denotes 42
16396836-12154409-76538213 4640-4642 12154409 denotes 42
16396836-14669283-76538213 4640-4642 14669283 denotes 42
16396836-14604977-76538213 4640-4642 14604977 denotes 42
16396836-9414265-76538214 4782-4784 9414265 denotes 27
16396836-8861914-76538215 4785-4787 8861914 denotes 46
16396836-11369663-76538216 4788-4790 11369663 denotes 47
16396836-10557056-76538217 5779-5781 10557056 denotes 49
16396836-11846982-76538218 6004-6006 11846982 denotes 11
16396836-12218129-76538219 6007-6009 12218129 denotes 31
16396836-10676951-76538220 6010-6012 10676951 denotes 50
16396836-10720141-76538220 6010-6012 10720141 denotes 50
16396836-11157493-76538220 6010-6012 11157493 denotes 50
16396836-11013272-76538221 6151-6152 11013272 denotes 3

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T11862 3097-3105 VB denotes inhibits
T11346 11-15 JJ denotes Many
T11347 16-23 JJ denotes genetic
T11348 24-31 NN denotes lesions
T11349 32-35 VB denotes are
T11350 36-41 VB denotes known
T11351 42-44 TO denotes to
T11352 45-54 VB denotes influence
T11353 55-59 NN denotes gene
T11354 60-70 NN denotes expression
T11355 71-73 IN denotes of
T11356 74-79 NN denotes tumor
T11357 80-90 NN denotes suppressor
T11358 91-96 NN denotes genes
T11359 98-105 IN denotes Whereas
T11360 106-115 NN denotes mutations
T11361 116-119 CC denotes and
T11362 120-129 NN denotes deletions
T11363 130-132 CC denotes or
T11364 133-143 NN denotes insertions
T11365 144-148 VB denotes have
T11366 149-158 JJ denotes permanent
T11367 159-166 NN denotes effects
T11368 166-167 -COMMA- denotes ,
T11369 168-178 JJ denotes reversible
T11370 179-189 NN denotes mechanisms
T11371 190-193 VB denotes are
T11372 194-198 NN denotes gene
T11373 199-210 NN denotes methylation
T11374 210-211 -COMMA- denotes ,
T11375 212-214 CC denotes or
T11376 215-225 NN denotes expression
T11377 226-229 CC denotes and
T11378 230-240 NN denotes activation
T11379 241-243 IN denotes of
T11380 244-257 NN denotes transcription
T11381 258-265 NN denotes factors
T11382 265-266 -COMMA- denotes ,
T11383 267-279 RB denotes respectively
T11384 281-283 PRP denotes We
T11385 284-291 VB denotes studied
T11386 292-293 DT denotes a
T11387 294-302 JJ denotes putative
T11388 303-308 NN denotes cause
T11389 309-312 IN denotes for
T11390 313-319 JJ denotes absent
T11391 320-325 NN denotes IRF-4
T11392 326-336 NN denotes expression
T11393 337-339 IN denotes in
T11394 340-348 NN denotes leukemia
T11395 349-354 NN denotes cells
T11396 355-358 CC denotes and
T11397 359-364 RB denotes first
T11398 365-372 VB denotes focused
T11399 373-375 IN denotes on
T11400 376-383 JJ denotes genetic
T11401 384-395 NN denotes aberrations
T11402 396-398 IN denotes of
T11403 399-402 DT denotes the
T11404 403-411 NN denotes promoter
T11405 413-415 PRP denotes We
T11406 416-424 VB denotes observed
T11407 425-427 DT denotes no
T11408 428-435 JJ denotes genetic
T11409 436-447 NN denotes alterations
T11410 448-450 IN denotes in
T11411 451-454 DT denotes the
T11412 455-460 NN denotes IRF-4
T11413 461-469 NN denotes promoter
T11414 469-470 -COMMA- denotes ,
T11415 471-476 WDT denotes which
T11416 477-480 MD denotes can
T11417 481-488 VB denotes account
T11418 489-492 IN denotes for
T11419 493-496 DT denotes the
T11420 497-501 NN denotes lack
T11421 502-504 IN denotes of
T11422 505-510 NN denotes IRF-4
T11423 511-521 NN denotes expression
T11424 521-522 -COLON- denotes :
T11425 523-526 DT denotes The
T11426 527-535 VB denotes detected
T11427 536-540 NN denotes base
T11428 541-545 NN denotes pair
T11429 546-553 NN denotes changes
T11430 554-556 IN denotes at
T11431 557-565 NN denotes position
T11432 566-571 NN denotes −1081
T11433 572-573 -LRB- denotes (
T11434 573-576 NN denotes T→C
T11435 577-589 NN denotes substitution
T11436 589-590 -RRB- denotes )
T11437 590-591 -COMMA- denotes ,
T11438 592-594 IN denotes at
T11439 595-603 NN denotes position
T11440 604-609 CD denotes −1068
T11441 610-611 -LRB- denotes (
T11442 611-614 NN denotes A→C
T11443 615-627 NN denotes substitution
T11444 627-628 -RRB- denotes )
T11445 629-632 CC denotes and
T11446 633-635 IN denotes at
T11447 636-644 NN denotes position
T11448 645-649 CD denotes −116
T11449 650-651 -LRB- denotes (
T11450 651-654 NN denotes A→C
T11451 655-667 NN denotes substitution
T11452 667-668 -RRB- denotes )
T11453 669-672 VB denotes are
T11454 673-681 JJ denotes unlikely
T11455 682-693 JJ denotes responsible
T11456 694-697 IN denotes for
T11457 698-704 JJ denotes absent
T11458 705-721 NN denotes IRF-4-expression
T11459 722-727 IN denotes since
T11460 728-731 DT denotes the
T11461 732-737 JJ denotes first
T11462 738-741 CD denotes two
T11463 742-751 NN denotes mutations
T11464 752-756 VB denotes were
T11465 757-762 VB denotes found
T11466 763-767 CC denotes both
T11467 768-770 IN denotes in
T11468 771-785 JJ denotes IRF-4-positive
T11469 786-789 CC denotes and
T11470 790-799 JJ denotes -negative
T11471 800-805 NN denotes cells
T11472 806-813 IN denotes whereas
T11473 814-817 DT denotes the
T11474 818-824 JJ denotes latter
T11475 825-831 NN denotes change
T11476 832-835 VB denotes was
T11477 836-839 RB denotes not
T11478 840-848 VB denotes detected
T11479 849-861 RB denotes consistently
T11480 862-864 IN denotes in
T11481 865-868 DT denotes all
T11482 869-883 JJ denotes IRF-4-negative
T11483 884-886 CC denotes or
T11484 887-896 JJ denotes -positive
T11485 897-902 NN denotes cells
T11486 903-906 CC denotes and
T11487 907-910 MD denotes may
T11488 911-915 RB denotes thus
T11489 916-918 VB denotes be
T11490 919-920 DT denotes a
T11491 921-933 NN denotes polymorphism
T11492 935-938 DT denotes All
T11493 939-944 CD denotes three
T11494 945-958 NN denotes substitutions
T11495 959-962 VB denotes did
T11496 963-966 RB denotes not
T11497 967-973 VB denotes change
T11498 974-977 DT denotes any
T11499 978-983 JJ denotes known
T11500 984-992 JJ denotes putative
T11501 993-1006 NN denotes transcription
T11502 1007-1013 NN denotes factor
T11503 1014-1021 NN denotes binding
T11504 1022-1027 NN denotes sites
T11505 1028-1029 -LRB- denotes (
T11506 1029-1034 CD denotes 30,31
T11507 1034-1035 -RRB- denotes )
T11508 1036-1039 CC denotes and
T11509 1040-1044 RB denotes also
T11510 1045-1047 VB denotes do
T11511 1048-1051 RB denotes not
T11512 1052-1058 VB denotes affect
T11513 1059-1062 DT denotes any
T11514 1063-1074 NN denotes restriction
T11515 1075-1080 NN denotes sites
T11516 1081-1083 CC denotes or
T11517 1084-1090 NN denotes primer
T11518 1091-1098 NN denotes binding
T11519 1099-1104 NN denotes sites
T11520 1105-1107 IN denotes of
T11521 1108-1111 DT denotes the
T11522 1112-1116 VB denotes used
T11523 1117-1123 NN denotes assays
T11524 1125-1132 RB denotes However
T11525 1132-1133 -COMMA- denotes ,
T11526 1134-1143 JJ denotes permanent
T11527 1144-1151 JJ denotes genetic
T11528 1152-1162 NN denotes variations
T11529 1163-1165 IN denotes in
T11530 1166-1169 DT denotes the
T11531 1170-1175 NN denotes IRF-4
T11532 1176-1182 NN denotes coding
T11533 1183-1191 NN denotes sequence
T11534 1191-1192 -COMMA- denotes ,
T11535 1193-1197 JJ denotes such
T11536 1198-1200 IN denotes as
T11537 1201-1210 NN denotes deletions
T11538 1211-1213 CC denotes or
T11539 1214-1223 NN denotes mutations
T11540 1224-1233 VB denotes resulting
T11541 1234-1236 IN denotes in
T11542 1237-1248 NN denotes stop-codons
T11543 1249-1253 VB denotes have
T11544 1254-1257 RB denotes not
T11545 1258-1262 VB denotes been
T11546 1263-1271 VB denotes excluded
T11547 1272-1274 IN denotes by
T11548 1275-1283 NN denotes sequence
T11549 1284-1292 NN denotes analysis
T11550 1294-1299 IN denotes Since
T11551 1300-1305 NN denotes IRF-4
T11552 1306-1316 NN denotes expression
T11553 1317-1319 IN denotes in
T11554 1320-1324 NN denotes cell
T11555 1325-1330 NN denotes lines
T11556 1331-1334 CC denotes and
T11557 1335-1338 NN denotes CML
T11558 1339-1342 MD denotes can
T11559 1343-1345 VB denotes be
T11560 1346-1353 VB denotes induced
T11561 1354-1356 IN denotes by
T11562 1357-1370 NN denotes demethylation
T11563 1371-1374 CC denotes and
T11564 1375-1385 JJ denotes successful
T11565 1386-1391 NN denotes IFN-α
T11566 1392-1399 NN denotes therapy
T11567 1400-1401 -LRB- denotes (
T11568 1401-1402 CD denotes 3
T11569 1402-1403 -RRB- denotes )
T11570 1403-1404 -COMMA- denotes ,
T11571 1405-1417 RB denotes respectively
T11572 1417-1418 -COMMA- denotes ,
T11573 1419-1422 DT denotes the
T11574 1423-1432 NN denotes existence
T11575 1433-1435 IN denotes of
T11576 1436-1440 JJ denotes such
T11577 1441-1448 JJ denotes genetic
T11578 1449-1460 NN denotes aberrations
T11579 1461-1466 VB denotes seems
T11580 1467-1475 JJ denotes unlikely
T11581 1477-1479 PRP denotes We
T11582 1480-1484 RB denotes then
T11583 1485-1497 VB denotes investigated
T11584 1498-1505 IN denotes whether
T11585 1506-1509 DT denotes the
T11586 1510-1520 RB denotes previously
T11587 1521-1530 VB denotes described
T11588 1531-1546 NN denotes down-regulation
T11589 1547-1549 IN denotes of
T11590 1550-1555 NN denotes IRF-4
T11591 1556-1566 NN denotes expression
T11592 1567-1569 IN denotes in
T11593 1570-1575 JJ denotes human
T11594 1576-1583 JJ denotes myeloid
T11595 1584-1593 NN denotes leukemias
T11596 1594-1597 VB denotes was
T11597 1598-1601 JJ denotes due
T11598 1602-1604 TO denotes to
T11599 1605-1606 DT denotes a
T11600 1607-1619 JJ denotes differential
T11601 1620-1636 NN denotes hypermethylation
T11602 1637-1639 IN denotes of
T11603 1640-1643 DT denotes the
T11604 1644-1652 NN denotes promoter
T11605 1652-1653 -COMMA- denotes ,
T11606 1654-1659 IN denotes since
T11607 1660-1663 DT denotes the
T11608 1664-1673 VB denotes presented
T11609 1674-1687 NN denotes re-expression
T11610 1688-1691 IN denotes due
T11611 1692-1694 TO denotes to
T11612 1695-1710 NN denotes AzadC-treatment
T11613 1711-1716 MD denotes might
T11614 1717-1721 RB denotes also
T11615 1722-1724 VB denotes be
T11616 1725-1726 DT denotes a
T11617 1727-1733 NN denotes result
T11618 1734-1736 IN denotes of
T11619 1737-1747 NN denotes activation
T11620 1748-1750 IN denotes of
T11621 1751-1759 JJ denotes positive
T11622 1760-1775 JJ denotes transcriptional
T11623 1776-1786 NN denotes regulators
T11624 1787-1789 IN denotes of
T11625 1790-1795 NN denotes IRF-4
T11626 1797-1808 NN denotes Methylation
T11627 1809-1811 IN denotes of
T11628 1812-1815 NN denotes CpG
T11629 1816-1821 NN denotes sites
T11630 1822-1824 VB denotes is
T11631 1825-1826 DT denotes a
T11632 1827-1833 JJ denotes common
T11633 1834-1843 NN denotes mechanism
T11634 1844-1846 IN denotes of
T11635 1847-1856 NN denotes silencing
T11636 1857-1862 NN denotes genes
T11637 1863-1865 IN denotes in
T11638 1866-1874 NN denotes leukemia
T11639 1875-1878 CC denotes and
T11640 1879-1882 VB denotes has
T11641 1883-1887 RB denotes also
T11642 1888-1892 VB denotes been
T11643 1893-1898 VB denotes shown
T11644 1899-1902 IN denotes for
T11645 1903-1910 DT denotes another
T11646 1911-1914 NN denotes IRF
T11647 1914-1915 -COMMA- denotes ,
T11648 1916-1921 NN denotes IRF-7
T11649 1922-1923 -LRB- denotes (
T11650 1923-1925 CD denotes 35
T11651 1925-1926 -RRB- denotes )
T11652 1927-1930 CC denotes and
T11653 1931-1934 IN denotes for
T11654 1935-1939 NN denotes PU.1
T11655 1940-1941 -LRB- denotes (
T11656 1941-1943 CD denotes 36
T11657 1943-1944 -RRB- denotes )
T11658 1944-1945 -COMMA- denotes ,
T11659 1946-1948 DT denotes an
T11660 1949-1960 VB denotes interacting
T11661 1961-1968 NN denotes partner
T11662 1969-1971 IN denotes of
T11663 1972-1977 NN denotes IRF-4
T11664 1979-1981 TO denotes To
T11665 1982-1991 VB denotes elucidate
T11666 1992-1995 DT denotes the
T11667 1996-2005 NN denotes relevance
T11668 2006-2008 IN denotes of
T11669 2009-2013 DT denotes this
T11670 2014-2023 NN denotes mechanism
T11671 2024-2027 IN denotes for
T11672 2028-2031 DT denotes the
T11673 2032-2042 NN denotes regulation
T11674 2043-2045 IN denotes of
T11675 2046-2051 NN denotes IRF-4
T11676 2052-2062 NN denotes expression
T11677 2062-2063 -COMMA- denotes ,
T11678 2064-2071 JJ denotes various
T11679 2072-2080 JJ denotes leukemic
T11680 2081-2086 NN denotes cells
T11681 2087-2091 VB denotes were
T11682 2092-2099 VB denotes treated
T11683 2100-2104 IN denotes with
T11684 2105-2118 VB denotes demethylating
T11685 2119-2125 NN denotes agents
T11686 2126-2129 CC denotes and
T11687 2130-2139 NN denotes promoters
T11688 2140-2144 VB denotes were
T11689 2145-2154 VB denotes sequenced
T11690 2155-2160 IN denotes after
T11691 2161-2170 NN denotes bisulfite
T11692 2171-2180 NN denotes treatment
T11693 2182-2184 PRP denotes We
T11694 2185-2190 VB denotes found
T11695 2191-2195 IN denotes that
T11696 2196-2201 NN denotes IRF-4
T11697 2202-2212 NN denotes expression
T11698 2213-2218 MD denotes could
T11699 2219-2225 RB denotes indeed
T11700 2226-2228 VB denotes be
T11701 2229-2238 VB denotes connected
T11702 2239-2241 TO denotes to
T11703 2242-2245 DT denotes the
T11704 2246-2257 NN denotes methylation
T11705 2258-2264 NN denotes status
T11706 2265-2267 IN denotes of
T11707 2268-2276 JJ denotes distinct
T11708 2277-2280 NN denotes CpG
T11709 2281-2287 NN denotes motifs
T11710 2288-2290 IN denotes in
T11711 2291-2294 DT denotes the
T11712 2295-2300 NN denotes IRF-4
T11713 2301-2309 NN denotes promoter
T11714 2311-2313 IN denotes In
T11715 2314-2320 NN denotes Figure
T11716 2321-2323 NN denotes 4A
T11717 2323-2324 -COMMA- denotes ,
T11718 2325-2330 DT denotes those
T11719 2331-2334 NN denotes CpG
T11720 2335-2340 NN denotes sites
T11721 2341-2344 VB denotes are
T11722 2345-2350 VB denotes shown
T11723 2351-2352 -LRB- denotes (
T11724 2352-2358 JJ denotes bottom
T11725 2359-2363 NN denotes line
T11726 2363-2364 -RRB- denotes )
T11727 2364-2365 -COMMA- denotes ,
T11728 2366-2371 WP-DOLLAR- denotes whose
T11729 2372-2388 NN denotes hypermethylation
T11730 2389-2392 MD denotes may
T11731 2393-2400 VB denotes account
T11732 2401-2404 IN denotes for
T11733 2405-2408 DT denotes the
T11734 2409-2416 NN denotes absence
T11735 2417-2419 IN denotes of
T11736 2420-2425 NN denotes IRF-4
T11737 2426-2436 NN denotes expression
T11738 2437-2439 IN denotes in
T11739 2440-2443 DT denotes the
T11740 2444-2454 JJ denotes respective
T11741 2455-2460 NN denotes cells
T11742 2462-2465 CD denotes One
T11743 2466-2468 IN denotes of
T11744 2469-2473 PRP denotes them
T11745 2474-2475 -LRB- denotes (
T11746 2475-2476 -SHARP- denotes #
T11747 2476-2478 CD denotes 54
T11748 2478-2479 -RRB- denotes )
T11749 2480-2482 VB denotes is
T11750 2483-2491 JJ denotes adjacent
T11751 2492-2494 TO denotes to
T11752 2495-2497 DT denotes an
T11753 2498-2508 VB denotes identified
T11754 2509-2519 JJ denotes regulatory
T11755 2520-2527 NN denotes element
T11756 2528-2529 -LRB- denotes (
T11757 2529-2538 NN denotes NFκB-site
T11758 2538-2539 -RRB- denotes )
T11759 2539-2540 -COMMA- denotes ,
T11760 2541-2551 VB denotes indicating
T11761 2552-2553 DT denotes a
T11762 2554-2562 JJ denotes possible
T11763 2563-2574 NN denotes involvement
T11764 2575-2577 IN denotes of
T11765 2578-2582 DT denotes this
T11766 2583-2587 NN denotes site
T11767 2589-2591 IN denotes At
T11768 2592-2595 CD denotes two
T11769 2596-2603 JJ denotes further
T11770 2604-2607 NN denotes CpG
T11771 2608-2613 NN denotes sites
T11772 2614-2615 -LRB- denotes (
T11773 2615-2616 -SHARP- denotes #
T11774 2616-2618 CD denotes 48
T11775 2618-2619 -COMMA- denotes ,
T11776 2620-2622 CD denotes 45
T11777 2622-2623 -RRB- denotes )
T11778 2624-2627 DT denotes the
T11779 2628-2639 NN denotes methylation
T11780 2640-2646 NN denotes status
T11781 2647-2649 IN denotes in
T11782 2650-2664 JJ denotes IRF-4-positive
T11783 2665-2668 VB denotes was
T11784 2669-2674 JJ denotes lower
T11785 2675-2679 IN denotes than
T11786 2680-2684 DT denotes that
T11787 2685-2687 IN denotes of
T11788 2688-2702 JJ denotes IRF-4-negative
T11789 2703-2708 NN denotes cells
T11790 2710-2715 DT denotes These
T11791 2716-2719 NN denotes CpG
T11792 2720-2725 NN denotes sites
T11793 2726-2729 VB denotes are
T11794 2730-2737 JJ denotes located
T11795 2738-2740 IN denotes in
T11796 2741-2743 DT denotes an
T11797 2744-2748 NN denotes NFκB
T11798 2749-2752 CC denotes and
T11799 2753-2755 DT denotes an
T11800 2756-2759 NN denotes SP1
T11801 2760-2767 NN denotes element
T11802 2768-2769 -LRB- denotes (
T11803 2769-2771 CD denotes 31
T11804 2771-2772 -RRB- denotes )
T11805 2773-2776 CC denotes and
T11806 2777-2781 RB denotes thus
T11807 2782-2785 MD denotes may
T11808 2786-2790 RB denotes also
T11809 2791-2795 VB denotes play
T11810 2796-2797 DT denotes a
T11811 2798-2802 NN denotes role
T11812 2803-2805 IN denotes in
T11813 2806-2816 NN denotes regulation
T11814 2817-2819 IN denotes of
T11815 2820-2825 NN denotes IRF-4
T11816 2826-2836 NN denotes expression
T11817 2838-2840 PRP denotes It
T11818 2841-2844 VB denotes has
T11819 2845-2849 VB denotes been
T11820 2850-2855 VB denotes shown
T11821 2856-2860 IN denotes that
T11822 2861-2865 NN denotes NFκB
T11823 2866-2874 NN denotes elements
T11824 2875-2879 VB denotes play
T11825 2880-2882 DT denotes an
T11826 2883-2892 JJ denotes important
T11827 2893-2897 NN denotes role
T11828 2898-2900 IN denotes in
T11829 2901-2906 NN denotes IRF-4
T11830 2907-2916 NN denotes induction
T11831 2917-2919 IN denotes as
T11832 2920-2925 NN denotes IRF-4
T11833 2926-2936 NN denotes expression
T11834 2937-2944 VB denotes depends
T11835 2945-2947 IN denotes on
T11836 2948-2955 NN denotes binding
T11837 2956-2958 IN denotes of
T11838 2959-2962 DT denotes the
T11839 2963-2977 NN denotes transactivator
T11840 2978-2983 NN denotes c-Rel
T11841 2984-2986 TO denotes to
T11842 2987-2992 DT denotes these
T11843 2993-3001 NN denotes elements
T11844 3002-3004 IN denotes in
T11845 3005-3008 DT denotes the
T11846 3009-3014 NN denotes IRF-4
T11847 3015-3023 NN denotes promoter
T11848 3024-3025 -LRB- denotes (
T11849 3025-3030 CD denotes 31,37
T11850 3030-3031 -RRB- denotes )
T11851 3033-3044 RB denotes Furthermore
T11852 3044-3045 -COMMA- denotes ,
T11853 3046-3057 NN denotes methylation
T11854 3058-3060 IN denotes of
T11855 3061-3064 DT denotes the
T11856 3065-3072 JJ denotes central
T11857 3073-3076 NN denotes CpG
T11858 3077-3079 IN denotes in
T11859 3080-3083 DT denotes the
T11860 3084-3088 NN denotes NFκB
T11861 3089-3096 NN denotes element
T11863 3106-3113 NN denotes binding
T11864 3114-3116 IN denotes of
T11865 3117-3120 DT denotes the
T11866 3121-3125 NN denotes NFκB
T11867 3126-3133 NN denotes protein
T11868 3134-3143 NN denotes complexes
T11869 3144-3145 -LRB- denotes (
T11870 3145-3147 CD denotes 38
T11871 3147-3148 -RRB- denotes )
T11872 3148-3149 -COMMA- denotes ,
T11873 3150-3159 VB denotes promoting
T11874 3160-3163 DT denotes the
T11875 3164-3176 NN denotes significance
T11876 3177-3179 IN denotes of
T11877 3180-3183 DT denotes the
T11878 3184-3192 VB denotes observed
T11879 3193-3204 NN denotes methylation
T11880 3205-3216 NN denotes differences
T11881 3217-3219 IN denotes in
T11882 3220-3234 JJ denotes IRF-4-positive
T11883 3235-3238 CC denotes and
T11884 3239-3248 JJ denotes -negative
T11885 3249-3254 NN denotes cells
T11886 3256-3259 NNP denotes Via
T11887 3260-3262 FW denotes in
T11888 3263-3268 FW denotes vitro
T11889 3269-3280 NN denotes methylation
T11890 3281-3284 CC denotes and
T11891 3285-3293 NN denotes reporter
T11892 3294-3298 NN denotes gene
T11893 3299-3305 NN denotes assays
T11894 3306-3308 PRP denotes we
T11895 3309-3314 MD denotes could
T11896 3315-3322 RB denotes clearly
T11897 3323-3330 VB denotes appoint
T11898 3331-3334 DT denotes the
T11899 3335-3344 NN denotes silencing
T11900 3345-3347 IN denotes of
T11901 3348-3351 DT denotes the
T11902 3352-3357 NN denotes IRF-4
T11903 3358-3366 NN denotes promoter
T11904 3367-3369 TO denotes to
T11905 3370-3371 DT denotes a
T11906 3372-3383 NN denotes methylation
T11907 3384-3390 NN denotes effect
T11908 3390-3391 -COMMA- denotes ,
T11909 3392-3397 WDT denotes which
T11910 3398-3401 MD denotes may
T11911 3402-3406 RB denotes thus
T11912 3407-3409 VB denotes be
T11913 3410-3413 DT denotes the
T11914 3414-3423 NN denotes mechanism
T11915 3424-3426 IN denotes of
T11916 3427-3432 NN denotes IRF-4
T11917 3433-3445 NN denotes deregulation
T11918 3446-3448 FW denotes in
T11919 3449-3453 FW denotes vivo
T11920 3455-3458 CD denotes One
T11921 3459-3467 JJ denotes possible
T11922 3468-3473 NN denotes cause
T11923 3474-3477 IN denotes for
T11924 3478-3481 DT denotes the
T11925 3482-3490 JJ denotes aberrant
T11926 3491-3502 NN denotes methylation
T11927 3503-3505 IN denotes in
T11928 3506-3519 NN denotes tumorigenesis
T11929 3520-3522 VB denotes is
T11930 3523-3525 DT denotes an
T11931 3526-3535 VB denotes increased
T11932 3536-3541 NN denotes level
T11933 3542-3544 IN denotes of
T11934 3545-3550 NN denotes DNMTs
T11935 3551-3557 IN denotes during
T11936 3558-3561 DT denotes the
T11937 3562-3574 JJ denotes pathogenetic
T11938 3575-3582 NN denotes process
T11939 3584-3586 IN denotes In
T11940 3587-3592 NN denotes colon
T11941 3592-3593 -COMMA- denotes ,
T11942 3594-3598 NN denotes lung
T11943 3599-3602 CC denotes and
T11944 3603-3614 JJ denotes hematologic
T11945 3615-3627 NN denotes malignancies
T11946 3627-3628 -COMMA- denotes ,
T11947 3629-3643 NN denotes overexpression
T11948 3644-3646 IN denotes of
T11949 3647-3652 NN denotes DNMT1
T11950 3652-3653 -COMMA- denotes ,
T11951 3654-3655 DT denotes a
T11952 3656-3667 NN denotes maintenance
T11953 3668-3672 NN denotes DNMT
T11954 3672-3673 -COMMA- denotes ,
T11955 3674-3677 VB denotes has
T11956 3678-3682 VB denotes been
T11957 3683-3691 VB denotes detected
T11958 3692-3693 -LRB- denotes (
T11959 3693-3698 CD denotes 39–41
T11960 3698-3699 -RRB- denotes )
T11961 3701-3712 RB denotes Furthermore
T11962 3712-3713 -COMMA- denotes ,
T11963 3714-3716 PRP denotes it
T11964 3717-3720 VB denotes has
T11965 3721-3725 VB denotes been
T11966 3726-3731 VB denotes shown
T11967 3732-3736 IN denotes that
T11968 3737-3740 NN denotes CML
T11969 3741-3746 NN denotes cells
T11970 3747-3749 IN denotes in
T11971 3750-3753 DT denotes the
T11972 3754-3759 JJ denotes acute
T11973 3760-3765 NN denotes phase
T11974 3766-3775 VB denotes exhibited
T11975 3776-3784 JJ denotes elevated
T11976 3785-3791 NN denotes levels
T11977 3792-3794 IN denotes of
T11978 3795-3798 DT denotes the
T11979 3799-3804 CD denotes three
T11980 3805-3810 VB denotes known
T11981 3811-3816 NN denotes DNMTs
T11982 3816-3817 -COMMA- denotes ,
T11983 3818-3823 IN denotes while
T11984 3824-3827 NN denotes CML
T11985 3828-3833 NN denotes cells
T11986 3834-3836 IN denotes in
T11987 3837-3844 JJ denotes chronic
T11988 3845-3850 NN denotes phase
T11989 3851-3860 VB denotes expressed
T11990 3861-3867 JJ denotes normal
T11991 3868-3874 NN denotes levels
T11992 3875-3877 IN denotes of
T11993 3878-3883 NN denotes DNMTs
T11994 3884-3886 IN denotes if
T11995 3887-3895 VB denotes compared
T11996 3896-3900 IN denotes with
T11997 3901-3907 JJ denotes normal
T11998 3908-3912 NN denotes bone
T11999 3913-3919 NN denotes marrow
T12000 3920-3925 NN denotes cells
T12001 3926-3927 -LRB- denotes (
T12002 3927-3929 CD denotes 25
T12003 3929-3930 -RRB- denotes )
T12004 3932-3945 RB denotes Interestingly
T12005 3945-3946 -COMMA- denotes ,
T12006 3947-3948 DT denotes a
T12007 3949-3957 JJ denotes positive
T12008 3958-3969 NN denotes correlation
T12009 3970-3977 IN denotes between
T12010 3978-3983 NN denotes DNMT1
T12011 3984-3994 NN denotes expression
T12012 3995-4001 NN denotes levels
T12013 4002-4005 CC denotes and
T12014 4006-4022 NN denotes hypermethylation
T12015 4023-4025 IN denotes of
T12016 4026-4034 NN denotes p15INK4b
T12017 4035-4038 VB denotes has
T12018 4039-4043 VB denotes been
T12019 4044-4052 VB denotes detected
T12020 4053-4055 IN denotes in
T12021 4056-4059 NN denotes AML
T12022 4060-4061 -LRB- denotes (
T12023 4061-4063 CD denotes 25
T12024 4063-4064 -RRB- denotes )
T12025 4066-4068 IN denotes In
T12026 4069-4073 DT denotes this
T12027 4074-4078 NN denotes work
T12028 4078-4079 -COMMA- denotes ,
T12029 4080-4082 PRP denotes we
T12030 4083-4086 VB denotes did
T12031 4087-4090 RB denotes not
T12032 4091-4097 VB denotes detect
T12033 4098-4109 JJ denotes significant
T12034 4110-4114 NN denotes mRNA
T12035 4115-4125 NN denotes expression
T12036 4126-4137 NN denotes differences
T12037 4138-4140 IN denotes of
T12038 4141-4149 VB denotes selected
T12039 4150-4154 NN denotes DNMT
T12040 4155-4157 CC denotes or
T12041 4158-4161 NN denotes MBP
T12042 4161-4162 -COMMA- denotes ,
T12043 4163-4169 VB denotes making
T12044 4170-4172 PRP denotes it
T12045 4173-4175 DT denotes an
T12046 4176-4184 JJ denotes unlikely
T12047 4185-4190 NN denotes cause
T12048 4191-4194 IN denotes for
T12049 4195-4198 DT denotes the
T12050 4199-4207 VB denotes observed
T12051 4208-4219 NN denotes methylation
T12052 4220-4223 CC denotes and
T12053 4224-4228 RB denotes thus
T12054 4229-4234 NN denotes IRF-4
T12055 4235-4245 NN denotes expression
T12056 4246-4257 NN denotes differences
T12057 4258-4260 IN denotes in
T12058 4261-4269 NN denotes leukemia
T12059 4270-4275 NN denotes cells
T12060 4277-4280 DT denotes The
T12061 4281-4288 NN denotes finding
T12062 4289-4293 IN denotes that
T12063 4294-4299 NN denotes IRF-4
T12064 4300-4310 NN denotes expression
T12065 4311-4313 VB denotes is
T12066 4314-4322 VB denotes silenced
T12067 4323-4325 IN denotes by
T12068 4326-4334 NN denotes promoter
T12069 4335-4351 NN denotes hypermethylation
T12070 4352-4357 MD denotes might
T12071 4358-4367 VB denotes represent
T12072 4368-4369 DT denotes a
T12073 4370-4379 NN denotes mechanism
T12074 4380-4384 WDT denotes that
T12075 4385-4393 VB denotes accounts
T12076 4394-4397 IN denotes for
T12077 4398-4401 DT denotes the
T12078 4402-4412 RB denotes previously
T12079 4413-4421 VB denotes observed
T12080 4422-4426 NN denotes loss
T12081 4427-4429 IN denotes of
T12082 4430-4435 NN denotes IRF-4
T12083 4436-4446 NN denotes expression
T12084 4447-4449 IN denotes in
T12085 4450-4453 NN denotes CML
T12086 4455-4461 RB denotes Indeed
T12087 4461-4462 -COMMA- denotes ,
T12088 4463-4470 JJ denotes several
T12089 4471-4479 JJ denotes clinical
T12090 4480-4486 NN denotes trials
T12091 4487-4491 IN denotes with
T12092 4492-4500 NN denotes leukemia
T12093 4501-4509 NN denotes patients
T12094 4510-4513 CC denotes and
T12095 4514-4522 NN denotes patients
T12096 4523-4527 IN denotes with
T12097 4528-4543 JJ denotes myelodysplastic
T12098 4544-4553 NN denotes syndromes
T12099 4554-4566 VB denotes demonstrated
T12100 4567-4570 DT denotes the
T12101 4571-4580 JJ denotes potential
T12102 4581-4589 JJ denotes clinical
T12103 4590-4597 NN denotes benefit
T12104 4598-4600 IN denotes of
T12105 4601-4602 DT denotes a
T12106 4603-4612 NN denotes treatment
T12107 4613-4617 IN denotes with
T12108 4618-4631 VB denotes demethylating
T12109 4632-4638 NN denotes agents
T12110 4639-4640 -LRB- denotes (
T12111 4640-4645 CD denotes 42–45
T12112 4645-4646 -RRB- denotes )
T12113 4648-4651 DT denotes The
T12114 4652-4662 NN denotes expression
T12115 4663-4665 IN denotes of
T12116 4666-4673 DT denotes another
T12117 4674-4677 NN denotes IRF
T12118 4677-4678 -COMMA- denotes ,
T12119 4679-4682 NN denotes IFN
T12120 4683-4692 NN denotes consensus
T12121 4693-4701 NN denotes sequence
T12122 4702-4709 NN denotes binding
T12123 4710-4717 NN denotes protein
T12124 4718-4719 -LRB- denotes (
T12125 4719-4730 NN denotes ICSBP/IRF-8
T12126 4730-4731 -RRB- denotes )
T12127 4731-4732 -COMMA- denotes ,
T12128 4733-4735 VB denotes is
T12129 4736-4744 JJ denotes impaired
T12130 4745-4747 IN denotes in
T12131 4748-4755 JJ denotes myeloid
T12132 4756-4765 NN denotes leukemias
T12133 4766-4776 RB denotes especially
T12134 4777-4780 NN denotes CML
T12135 4781-4782 -LRB- denotes (
T12136 4782-4790 CD denotes 27,46,47
T12137 4790-4791 -RRB- denotes )
T12138 4793-4796 CC denotes But
T12139 4797-4799 IN denotes in
T12140 4800-4808 NN denotes contrast
T12141 4809-4811 TO denotes to
T12142 4812-4817 NN denotes IRF-4
T12143 4817-4818 -COMMA- denotes ,
T12144 4819-4822 DT denotes the
T12145 4823-4827 NN denotes loss
T12146 4828-4830 IN denotes of
T12147 4831-4835 DT denotes this
T12148 4836-4839 NN denotes IRF
T12149 4840-4845 MD denotes could
T12150 4846-4849 RB denotes not
T12151 4850-4852 VB denotes be
T12152 4853-4861 VB denotes reverted
T12153 4862-4864 IN denotes in
T12154 4865-4879 JJ denotes ICSBP-negative
T12155 4880-4884 NN denotes cell
T12156 4885-4890 NN denotes lines
T12157 4891-4892 -LRB- denotes (
T12158 4892-4896 NN denotes EM-2
T12159 4896-4897 -COMMA- denotes ,
T12160 4898-4904 NN denotes CML-T1
T12161 4904-4905 -COMMA- denotes ,
T12162 4906-4911 NN denotes K-562
T12163 4912-4915 CC denotes and
T12164 4916-4923 NN denotes LAMA-84
T12165 4923-4924 -RRB- denotes )
T12166 4925-4927 IN denotes by
T12167 4928-4937 NN denotes treatment
T12168 4938-4942 IN denotes with
T12169 4943-4948 NN denotes AzadC
T12170 4949-4950 -LRB- denotes (
T12171 4950-4956 NN denotes Figure
T12172 4957-4958 CD denotes 6
T12173 4958-4959 -RRB- denotes )
T12174 4960-4963 CC denotes and
T12175 4964-4969 NN denotes AzadC
T12176 4970-4973 VB denotes has
T12177 4974-4976 DT denotes no
T12178 4977-4983 NN denotes effect
T12179 4984-4986 IN denotes on
T12180 4987-4992 NN denotes ICSBP
T12181 4993-4999 NN denotes levels
T12182 5000-5002 IN denotes in
T12183 5003-5017 JJ denotes ICSBP-positive
T12184 5018-5023 NN denotes U-937
T12185 5024-5029 NN denotes cells
T12186 5030-5031 -LRB- denotes (
T12187 5031-5037 NN denotes Figure
T12188 5038-5039 CD denotes 6
T12189 5039-5040 -RRB- denotes )
T12190 5042-5047 DT denotes These
T12191 5048-5052 NN denotes data
T12192 5053-5060 VB denotes suggest
T12193 5061-5062 DT denotes a
T12194 5063-5071 JJ denotes distinct
T12195 5072-5082 JJ denotes regulatory
T12196 5083-5092 NN denotes mechanism
T12197 5093-5096 IN denotes for
T12198 5097-5102 DT denotes these
T12199 5103-5106 CD denotes two
T12200 5107-5111 NN denotes IRFs
T12201 5113-5118 NN denotes IRF-4
T12202 5118-5119 -COMMA- denotes ,
T12203 5120-5127 JJ denotes similar
T12204 5128-5130 TO denotes to
T12205 5131-5135 JJ denotes many
T12206 5136-5141 JJ denotes other
T12207 5142-5151 JJ denotes classical
T12208 5152-5157 NN denotes tumor
T12209 5158-5168 NN denotes suppressor
T12210 5169-5174 NN denotes genes
T12211 5175-5183 NN denotes p15INK4b
T12212 5183-5184 -COMMA- denotes ,
T12213 5185-5193 NN denotes p16INK4a
T12214 5194-5196 CC denotes or
T12215 5197-5200 NN denotes p53
T12216 5200-5201 -COMMA- denotes ,
T12217 5202-5205 MD denotes may
T12218 5206-5210 RB denotes thus
T12219 5211-5213 VB denotes be
T12220 5214-5215 DT denotes a
T12221 5216-5223 NN denotes subject
T12222 5224-5226 IN denotes of
T12223 5227-5238 NN denotes alterations
T12224 5239-5241 IN denotes in
T12225 5242-5245 DT denotes the
T12226 5246-5254 NN denotes promoter
T12227 5255-5266 NN denotes methylation
T12228 5267-5273 NN denotes status
T12229 5274-5281 VB denotes leading
T12230 5282-5284 TO denotes to
T12231 5285-5295 NN denotes expression
T12232 5296-5303 NN denotes changes
T12233 5303-5304 -COMMA- denotes ,
T12234 5305-5310 WDT denotes which
T12235 5311-5316 MD denotes might
T12236 5317-5327 VB denotes contribute
T12237 5328-5330 TO denotes to
T12238 5331-5334 DT denotes the
T12239 5335-5345 NN denotes initiation
T12240 5346-5352 CC denotes and/or
T12241 5353-5364 NN denotes progression
T12242 5365-5367 IN denotes of
T12243 5368-5374 NN denotes cancer
T12244 5376-5381 RB denotes Still
T12245 5381-5382 -COMMA- denotes ,
T12246 5383-5386 DT denotes the
T12247 5387-5394 JJ denotes obvious
T12248 5395-5405 JJ denotes functional
T12249 5406-5415 NN denotes diversity
T12250 5416-5418 IN denotes of
T12251 5419-5424 NN denotes IRF-4
T12252 5425-5432 VB denotes remains
T12253 5433-5443 JJ denotes remarkable
T12254 5444-5447 CC denotes and
T12255 5448-5451 MD denotes can
T12256 5451-5454 RB denotes not
T12257 5455-5457 VB denotes be
T12258 5458-5463 RB denotes fully
T12259 5464-5473 VB denotes explained
T12260 5474-5476 IN denotes by
T12261 5477-5480 DT denotes the
T12262 5481-5486 NN denotes IRF-4
T12263 5487-5495 NN denotes promoter
T12264 5496-5507 NN denotes methylation
T12265 5508-5514 NN denotes status
T12266 5516-5519 IN denotes For
T12267 5520-5527 NN denotes example
T12268 5527-5528 -COMMA- denotes ,
T12269 5529-5534 NN denotes IRF-4
T12270 5535-5537 VB denotes is
T12271 5538-5547 RB denotes primarily
T12272 5548-5553 VB denotes known
T12273 5554-5557 IN denotes for
T12274 5558-5561 PRP-DOLLAR- denotes its
T12275 5562-5571 JJ denotes oncogenic
T12276 5572-5580 NN denotes features
T12277 5582-5584 IN denotes In
T12278 5585-5593 JJ denotes multiple
T12279 5594-5601 NN denotes myeloma
T12280 5602-5603 -LRB- denotes (
T12281 5603-5605 NN denotes MM
T12282 5605-5606 -RRB- denotes )
T12283 5607-5608 DT denotes a
T12284 5609-5622 NN denotes translocation
T12285 5623-5625 IN denotes on
T12286 5626-5636 NN denotes chromosome
T12287 5637-5640 NN denotes 14q
T12288 5641-5644 VB denotes was
T12289 5645-5653 VB denotes reported
T12290 5654-5656 TO denotes to
T12291 5657-5661 VB denotes lead
T12292 5662-5664 TO denotes to
T12293 5665-5666 DT denotes a
T12294 5667-5673 NN denotes fusion
T12295 5674-5678 NN denotes gene
T12296 5679-5681 IN denotes of
T12297 5682-5696 NN denotes immunoglobulin
T12298 5697-5708 NN denotes heavy-chain
T12299 5709-5710 -LRB- denotes (
T12300 5710-5713 NN denotes IgH
T12301 5713-5714 -RRB- denotes )
T12302 5715-5718 CC denotes and
T12303 5719-5724 NN denotes IRF-4
T12304 5725-5734 VB denotes resulting
T12305 5735-5737 IN denotes in
T12306 5738-5739 DT denotes a
T12307 5740-5750 JJ denotes subsequent
T12308 5751-5765 NN denotes overexpression
T12309 5766-5768 IN denotes of
T12310 5769-5774 NN denotes IRF-4
T12311 5775-5776 -LRB- denotes (
T12312 5776-5781 CD denotes 48,49
T12313 5781-5782 -RRB- denotes )
T12314 5784-5786 IN denotes In
T12315 5787-5795 NN denotes addition
T12316 5795-5796 -COMMA- denotes ,
T12317 5797-5805 JJ denotes abundant
T12318 5806-5811 NN denotes IRF-4
T12319 5812-5822 NN denotes expression
T12320 5823-5826 VB denotes was
T12321 5827-5832 VB denotes found
T12322 5833-5835 TO denotes to
T12323 5836-5838 VB denotes be
T12324 5839-5840 DT denotes a
T12325 5841-5847 NN denotes marker
T12326 5848-5851 IN denotes for
T12327 5852-5859 JJ denotes various
T12328 5860-5867 NN denotes subsets
T12329 5868-5870 IN denotes of
T12330 5871-5880 NN denotes lymphomas
T12331 5880-5881 -COMMA- denotes ,
T12332 5882-5886 JJ denotes such
T12333 5887-5889 IN denotes as
T12334 5890-5897 JJ denotes diffuse
T12335 5898-5903 JJ denotes large
T12336 5904-5910 NN denotes B-cell
T12337 5911-5920 NN denotes lymphomas
T12338 5920-5921 -COMMA- denotes ,
T12339 5922-5929 JJ denotes primary
T12340 5930-5938 NN denotes effusion
T12341 5939-5947 NN denotes lymphoma
T12342 5947-5948 -COMMA- denotes ,
T12343 5949-5952 CC denotes and
T12344 5953-5961 JJ denotes marginal
T12345 5962-5966 NN denotes zone
T12346 5967-5975 NN denotes lymphoma
T12347 5975-5976 -COMMA- denotes ,
T12348 5977-5980 CC denotes and
T12349 5981-5986 JJ denotes adult
T12350 5987-5993 NN denotes T-cell
T12351 5994-6002 NN denotes leukemia
T12352 6003-6004 -LRB- denotes (
T12353 6004-6015 CD denotes 11,31,50–52
T12354 6015-6016 -RRB- denotes )
T12355 6018-6022 DT denotes This
T12356 6023-6028 VB denotes draws
T12357 6029-6030 DT denotes a
T12358 6031-6035 RB denotes more
T12359 6036-6043 JJ denotes complex
T12360 6044-6051 NN denotes picture
T12361 6052-6054 IN denotes of
T12362 6055-6058 DT denotes the
T12363 6059-6063 NN denotes role
T12364 6064-6066 IN denotes of
T12365 6067-6072 NN denotes IRF-4
T12366 6074-6089 NN denotes Down-regulation
T12367 6090-6092 IN denotes of
T12368 6093-6098 NN denotes IRF-4
T12369 6099-6102 MD denotes may
T12370 6103-6110 VB denotes promote
T12371 6111-6125 NN denotes leukemogenesis
T12372 6126-6128 IN denotes in
T12373 6129-6136 JJ denotes myeloid
T12374 6137-6141 NN denotes cell
T12375 6142-6149 NN denotes context
T12376 6150-6151 -LRB- denotes (
T12377 6151-6152 CD denotes 3
T12378 6152-6153 -RRB- denotes )
T12379 6153-6154 -COMMA- denotes ,
T12380 6155-6160 WDT denotes which
T12381 6161-6164 VB denotes was
T12382 6165-6173 RB denotes recently
T12383 6174-6183 VB denotes confirmed
T12384 6184-6186 IN denotes in
T12385 6187-6195 NN denotes IRF-4−/−
T12386 6196-6204 NN denotes ICSBP−/−
T12387 6205-6211 JJ denotes double
T12388 6212-6221 JJ denotes knock-out
T12389 6222-6226 NN denotes mice
T12390 6227-6228 -LRB- denotes (
T12391 6228-6230 CD denotes 53
T12392 6230-6231 -RRB- denotes )
T12393 6231-6232 -COMMA- denotes ,
T12394 6233-6238 IN denotes while
T12395 6239-6244 NN denotes IRF-4
T12396 6245-6258 NN denotes up-regulation
T12397 6259-6262 MD denotes may
T12398 6263-6269 VB denotes induce
T12399 6270-6271 DT denotes a
T12400 6272-6278 NN denotes growth
T12401 6279-6288 NN denotes advantage
T12402 6289-6291 IN denotes in
T12403 6292-6301 NN denotes lymphomas
T12404 6302-6304 CC denotes or
T12405 6305-6307 NN denotes MM
T12406 6308-6309 -LRB- denotes (
T12407 6309-6311 CD denotes 48
T12408 6311-6312 -RRB- denotes )
T12409 6314-6319 VB denotes Taken
T12410 6320-6328 RB denotes together
T12411 6328-6329 -COMMA- denotes ,
T12412 6330-6333 PRP-DOLLAR- denotes our
T12413 6334-6338 NN denotes data
T12414 6339-6346 VB denotes suggest
T12415 6347-6351 IN denotes that
T12416 6352-6357 NN denotes IRF-4
T12417 6358-6366 NN denotes promoter
T12418 6367-6378 NN denotes methylation
T12419 6379-6388 VB denotes regulates
T12420 6389-6394 NN denotes IRF-4
T12421 6395-6405 NN denotes expression
T12422 6405-6406 -COMMA- denotes ,
T12423 6407-6410 CC denotes and
T12424 6411-6415 IN denotes that
T12425 6416-6424 JJ denotes aberrant
T12426 6425-6435 NN denotes expression
T12427 6436-6438 IN denotes of
T12428 6439-6444 NN denotes IRF-4
T12429 6445-6447 IN denotes in
T12430 6448-6455 JJ denotes certain
T12431 6456-6461 NN denotes types
T12432 6462-6464 IN denotes of
T12433 6465-6473 NN denotes leukemia
T12434 6474-6477 MD denotes may
T12435 6478-6480 VB denotes be
T12436 6481-6482 DT denotes a
T12437 6483-6494 NN denotes consequence
T12438 6495-6497 IN denotes of
T12439 6498-6503 NN denotes IRF-4
T12440 6504-6512 NN denotes promoter
T12441 6513-6529 NN denotes hypermethylation
R9224 T11348 T11346 arg1Of lesions,Many
R9225 T11348 T11347 arg1Of lesions,genetic
R9226 T11348 T11349 arg1Of lesions,are
R9227 T11348 T11350 arg2Of lesions,known
R9228 T11348 T11352 arg1Of lesions,influence
R9229 T11350 T11349 arg2Of known,are
R9230 T11352 T11350 arg3Of influence,known
R9231 T11352 T11351 arg1Of influence,to
R9232 T11354 T11352 arg2Of expression,influence
R9233 T11354 T11353 arg1Of expression,gene
R9234 T11354 T11355 arg1Of expression,of
R9235 T11358 T11355 arg2Of genes,of
R9236 T11358 T11356 arg1Of genes,tumor
R9237 T11358 T11357 arg1Of genes,suppressor
R9238 T11360 T11361 arg1Of mutations,and
R9239 T11361 T11365 arg1Of and,have
R9240 T11362 T11363 arg1Of deletions,or
R9241 T11363 T11361 arg2Of or,and
R9242 T11364 T11363 arg2Of insertions,or
R9243 T11365 T11359 arg2Of have,Whereas
R9244 T11367 T11365 arg2Of effects,have
R9245 T11367 T11366 arg1Of effects,permanent
R9246 T11370 T11369 arg1Of mechanisms,reversible
R9247 T11370 T11371 arg1Of mechanisms,are
R9248 T11371 T11359 arg1Of are,Whereas
R9249 T11371 T11368 arg1Of are,","
R9250 T11371 T11382 arg1Of are,","
R9251 T11371 T11383 arg1Of are,respectively
R9252 T11373 T11372 arg1Of methylation,gene
R9253 T11373 T11375 arg1Of methylation,or
R9254 T11375 T11371 arg2Of or,are
R9255 T11375 T11374 arg1Of or,","
R9256 T11375 T11379 arg1Of or,of
R9257 T11376 T11377 arg1Of expression,and
R9258 T11377 T11375 arg2Of and,or
R9259 T11378 T11377 arg2Of activation,and
R9260 T11381 T11379 arg2Of factors,of
R9261 T11381 T11380 arg1Of factors,transcription
R9262 T11384 T11385 arg1Of We,studied
R9263 T11384 T11398 arg1Of We,focused
R9264 T11385 T11396 arg1Of studied,and
R9265 T11388 T11385 arg2Of cause,studied
R9266 T11388 T11386 arg1Of cause,a
R9267 T11388 T11387 arg1Of cause,putative
R9268 T11388 T11389 arg1Of cause,for
R9269 T11392 T11389 arg2Of expression,for
R9270 T11392 T11390 arg1Of expression,absent
R9271 T11392 T11391 arg1Of expression,IRF-4
R9272 T11392 T11393 arg1Of expression,in
R9273 T11395 T11393 arg2Of cells,in
R9274 T11395 T11394 arg1Of cells,leukemia
R9275 T11398 T11396 arg2Of focused,and
R9276 T11398 T11397 arg1Of focused,first
R9277 T11398 T11399 arg1Of focused,on
R9278 T11401 T11399 arg2Of aberrations,on
R9279 T11401 T11400 arg1Of aberrations,genetic
R9280 T11401 T11402 arg1Of aberrations,of
R9281 T11404 T11402 arg2Of promoter,of
R9282 T11404 T11403 arg1Of promoter,the
R9283 T11405 T11406 arg1Of We,observed
R9284 T11406 T11424 arg1Of observed,:
R9285 T11409 T11406 arg2Of alterations,observed
R9286 T11409 T11407 arg1Of alterations,no
R9287 T11409 T11408 arg1Of alterations,genetic
R9288 T11409 T11410 arg1Of alterations,in
R9289 T11413 T11410 arg2Of promoter,in
R9290 T11413 T11411 arg1Of promoter,the
R9291 T11413 T11412 arg1Of promoter,IRF-4
R9292 T11413 T11414 arg1Of promoter,","
R9293 T11413 T11415 arg1Of promoter,which
R9294 T11413 T11416 arg1Of promoter,can
R9295 T11413 T11417 arg1Of promoter,account
R9296 T11417 T11416 arg2Of account,can
R9297 T11417 T11418 arg1Of account,for
R9298 T11420 T11418 arg2Of lack,for
R9299 T11420 T11419 arg1Of lack,the
R9300 T11420 T11421 arg1Of lack,of
R9301 T11423 T11421 arg2Of expression,of
R9302 T11423 T11422 arg1Of expression,IRF-4
R9303 T11429 T11425 arg1Of changes,The
R9304 T11429 T11426 arg2Of changes,detected
R9305 T11429 T11427 arg1Of changes,base
R9306 T11429 T11428 arg1Of changes,pair
R9307 T11429 T11430 arg1Of changes,at
R9308 T11429 T11437 arg1Of changes,","
R9309 T11429 T11438 arg1Of changes,at
R9310 T11429 T11446 arg1Of changes,at
R9311 T11429 T11453 arg1Of changes,are
R9312 T11432 T11430 arg2Of −1081,at
R9313 T11432 T11431 arg1Of −1081,position
R9314 T11432 T11433 arg1Of −1081,(
R9315 T11435 T11433 arg2Of substitution,(
R9316 T11435 T11434 arg1Of substitution,T→C
R9317 T11436 T11433 arg3Of ),(
R9318 T11438 T11445 arg1Of at,and
R9319 T11439 T11438 arg2Of position,at
R9320 T11439 T11440 arg1Of position,−1068
R9321 T11439 T11441 arg1Of position,(
R9322 T11443 T11441 arg2Of substitution,(
R9323 T11443 T11442 arg1Of substitution,A→C
R9324 T11444 T11441 arg3Of ),(
R9325 T11446 T11445 arg2Of at,and
R9326 T11447 T11446 arg2Of position,at
R9327 T11447 T11448 arg1Of position,−116
R9328 T11447 T11449 arg1Of position,(
R9329 T11451 T11449 arg2Of substitution,(
R9330 T11451 T11450 arg1Of substitution,A→C
R9331 T11452 T11449 arg3Of ),(
R9332 T11453 T11472 arg1Of are,whereas
R9333 T11455 T11456 arg1Of responsible,for
R9334 T11455 T11469 arg1Of responsible,and
R9335 T11458 T11456 arg2Of IRF-4-expression,for
R9336 T11458 T11457 arg1Of IRF-4-expression,absent
R9337 T11458 T11459 arg1Of IRF-4-expression,since
R9338 T11463 T11460 arg1Of mutations,the
R9339 T11463 T11461 arg1Of mutations,first
R9340 T11463 T11462 arg1Of mutations,two
R9341 T11463 T11464 arg1Of mutations,were
R9342 T11463 T11465 arg2Of mutations,found
R9343 T11465 T11459 arg2Of found,since
R9344 T11465 T11464 arg2Of found,were
R9345 T11465 T11467 arg1Of found,in
R9346 T11467 T11466 arg1Of in,both
R9347 T11468 T11467 arg2Of IRF-4-positive,in
R9348 T11470 T11469 arg2Of -negative,and
R9349 T11471 T11453 arg2Of cells,are
R9350 T11471 T11454 arg1Of cells,unlikely
R9351 T11471 T11455 arg1Of cells,responsible
R9352 T11471 T11470 arg1Of cells,-negative
R9353 T11475 T11473 arg1Of change,the
R9354 T11475 T11474 arg1Of change,latter
R9355 T11475 T11476 arg1Of change,was
R9356 T11475 T11478 arg2Of change,detected
R9357 T11475 T11487 arg1Of change,may
R9358 T11475 T11489 arg1Of change,be
R9359 T11478 T11476 arg2Of detected,was
R9360 T11478 T11477 arg1Of detected,not
R9361 T11478 T11479 arg1Of detected,consistently
R9362 T11478 T11480 arg1Of detected,in
R9363 T11478 T11486 arg1Of detected,and
R9364 T11482 T11483 arg1Of IRF-4-negative,or
R9365 T11484 T11483 arg2Of -positive,or
R9366 T11485 T11480 arg2Of cells,in
R9367 T11485 T11481 arg1Of cells,all
R9368 T11485 T11482 arg1Of cells,IRF-4-negative
R9369 T11485 T11484 arg1Of cells,-positive
R9370 T11486 T11472 arg2Of and,whereas
R9371 T11489 T11486 arg2Of be,and
R9372 T11489 T11487 arg2Of be,may
R9373 T11489 T11488 arg1Of be,thus
R9374 T11491 T11489 arg2Of polymorphism,be
R9375 T11491 T11490 arg1Of polymorphism,a
R9376 T11494 T11492 arg1Of substitutions,All
R9377 T11494 T11493 arg1Of substitutions,three
R9378 T11494 T11495 arg1Of substitutions,did
R9379 T11494 T11497 arg1Of substitutions,change
R9380 T11494 T11510 arg1Of substitutions,do
R9381 T11494 T11512 arg1Of substitutions,affect
R9382 T11497 T11495 arg2Of change,did
R9383 T11497 T11496 arg1Of change,not
R9384 T11497 T11508 arg1Of change,and
R9385 T11504 T11497 arg2Of sites,change
R9386 T11504 T11498 arg1Of sites,any
R9387 T11504 T11499 arg1Of sites,known
R9388 T11504 T11500 arg1Of sites,putative
R9389 T11504 T11501 arg1Of sites,transcription
R9390 T11504 T11502 arg1Of sites,factor
R9391 T11504 T11503 arg1Of sites,binding
R9392 T11504 T11505 arg1Of sites,(
R9393 T11506 T11505 arg2Of "30,31",(
R9394 T11507 T11505 arg3Of ),(
R9395 T11512 T11508 arg2Of affect,and
R9396 T11512 T11509 arg1Of affect,also
R9397 T11512 T11510 arg2Of affect,do
R9398 T11512 T11511 arg1Of affect,not
R9399 T11515 T11514 arg1Of sites,restriction
R9400 T11515 T11516 arg1Of sites,or
R9401 T11516 T11512 arg2Of or,affect
R9402 T11516 T11513 arg1Of or,any
R9403 T11516 T11520 arg1Of or,of
R9404 T11519 T11516 arg2Of sites,or
R9405 T11519 T11517 arg1Of sites,primer
R9406 T11519 T11518 arg1Of sites,binding
R9407 T11523 T11520 arg2Of assays,of
R9408 T11523 T11521 arg1Of assays,the
R9409 T11523 T11522 arg2Of assays,used
R9410 T11528 T11526 arg1Of variations,permanent
R9411 T11528 T11527 arg1Of variations,genetic
R9412 T11528 T11529 arg1Of variations,in
R9413 T11528 T11534 arg1Of variations,","
R9414 T11528 T11536 arg1Of variations,as
R9415 T11528 T11543 arg1Of variations,have
R9416 T11528 T11545 arg1Of variations,been
R9417 T11528 T11546 arg2Of variations,excluded
R9418 T11533 T11529 arg2Of sequence,in
R9419 T11533 T11530 arg1Of sequence,the
R9420 T11533 T11531 arg1Of sequence,IRF-4
R9421 T11533 T11532 arg1Of sequence,coding
R9422 T11536 T11535 arg1Of as,such
R9423 T11537 T11538 arg1Of deletions,or
R9424 T11538 T11536 arg2Of or,as
R9425 T11538 T11540 arg1Of or,resulting
R9426 T11539 T11538 arg2Of mutations,or
R9427 T11540 T11541 arg1Of resulting,in
R9428 T11542 T11541 arg2Of stop-codons,in
R9429 T11546 T11524 arg1Of excluded,However
R9430 T11546 T11525 arg1Of excluded,","
R9431 T11546 T11543 arg2Of excluded,have
R9432 T11546 T11544 arg1Of excluded,not
R9433 T11546 T11545 arg2Of excluded,been
R9434 T11549 T11546 arg1Of analysis,excluded
R9435 T11549 T11547 arg2Of analysis,by
R9436 T11549 T11548 arg1Of analysis,sequence
R9437 T11552 T11551 arg1Of expression,IRF-4
R9438 T11552 T11553 arg1Of expression,in
R9439 T11552 T11558 arg1Of expression,can
R9440 T11552 T11559 arg1Of expression,be
R9441 T11552 T11560 arg2Of expression,induced
R9442 T11555 T11554 arg1Of lines,cell
R9443 T11555 T11556 arg1Of lines,and
R9444 T11556 T11553 arg2Of and,in
R9445 T11557 T11556 arg2Of CML,and
R9446 T11560 T11550 arg2Of induced,Since
R9447 T11560 T11558 arg2Of induced,can
R9448 T11560 T11559 arg2Of induced,be
R9449 T11560 T11570 arg1Of induced,","
R9450 T11560 T11571 arg1Of induced,respectively
R9451 T11562 T11563 arg1Of demethylation,and
R9452 T11563 T11560 arg1Of and,induced
R9453 T11563 T11561 arg2Of and,by
R9454 T11566 T11563 arg2Of therapy,and
R9455 T11566 T11564 arg1Of therapy,successful
R9456 T11566 T11565 arg1Of therapy,IFN-α
R9457 T11566 T11567 arg1Of therapy,(
R9458 T11568 T11567 arg2Of 3,(
R9459 T11569 T11567 arg3Of ),(
R9460 T11574 T11573 arg1Of existence,the
R9461 T11574 T11575 arg1Of existence,of
R9462 T11574 T11579 arg1Of existence,seems
R9463 T11574 T11580 arg1Of existence,unlikely
R9464 T11578 T11575 arg2Of aberrations,of
R9465 T11578 T11576 arg1Of aberrations,such
R9466 T11578 T11577 arg1Of aberrations,genetic
R9467 T11579 T11550 arg1Of seems,Since
R9468 T11579 T11572 arg1Of seems,","
R9469 T11580 T11579 arg2Of unlikely,seems
R9470 T11581 T11583 arg1Of We,investigated
R9471 T11583 T11582 arg1Of investigated,then
R9472 T11587 T11586 arg1Of described,previously
R9473 T11588 T11585 arg1Of down-regulation,the
R9474 T11588 T11587 arg1Of down-regulation,described
R9475 T11588 T11589 arg1Of down-regulation,of
R9476 T11588 T11596 arg1Of down-regulation,was
R9477 T11588 T11597 arg1Of down-regulation,due
R9478 T11591 T11589 arg2Of expression,of
R9479 T11591 T11590 arg1Of expression,IRF-4
R9480 T11591 T11592 arg1Of expression,in
R9481 T11595 T11592 arg2Of leukemias,in
R9482 T11595 T11593 arg1Of leukemias,human
R9483 T11595 T11594 arg1Of leukemias,myeloid
R9484 T11596 T11583 arg2Of was,investigated
R9485 T11596 T11584 arg1Of was,whether
R9486 T11596 T11605 arg1Of was,","
R9487 T11596 T11606 arg1Of was,since
R9488 T11597 T11596 arg2Of due,was
R9489 T11597 T11598 arg1Of due,to
R9490 T11601 T11598 arg2Of hypermethylation,to
R9491 T11601 T11599 arg1Of hypermethylation,a
R9492 T11601 T11600 arg1Of hypermethylation,differential
R9493 T11601 T11602 arg1Of hypermethylation,of
R9494 T11604 T11602 arg2Of promoter,of
R9495 T11604 T11603 arg1Of promoter,the
R9496 T11609 T11607 arg1Of re-expression,the
R9497 T11609 T11608 arg2Of re-expression,presented
R9498 T11609 T11610 arg1Of re-expression,due
R9499 T11609 T11613 arg1Of re-expression,might
R9500 T11609 T11615 arg1Of re-expression,be
R9501 T11610 T11611 arg1Of due,to
R9502 T11612 T11610 arg2Of AzadC-treatment,due
R9503 T11615 T11606 arg2Of be,since
R9504 T11615 T11613 arg2Of be,might
R9505 T11615 T11614 arg1Of be,also
R9506 T11617 T11615 arg2Of result,be
R9507 T11617 T11616 arg1Of result,a
R9508 T11617 T11618 arg1Of result,of
R9509 T11619 T11618 arg2Of activation,of
R9510 T11619 T11620 arg1Of activation,of
R9511 T11623 T11620 arg2Of regulators,of
R9512 T11623 T11621 arg1Of regulators,positive
R9513 T11623 T11622 arg1Of regulators,transcriptional
R9514 T11623 T11624 arg1Of regulators,of
R9515 T11625 T11624 arg2Of IRF-4,of
R9516 T11626 T11627 arg1Of Methylation,of
R9517 T11626 T11630 arg1Of Methylation,is
R9518 T11626 T11640 arg1Of Methylation,has
R9519 T11626 T11642 arg1Of Methylation,been
R9520 T11626 T11643 arg2Of Methylation,shown
R9521 T11629 T11627 arg2Of sites,of
R9522 T11629 T11628 arg1Of sites,CpG
R9523 T11630 T11639 arg1Of is,and
R9524 T11633 T11630 arg2Of mechanism,is
R9525 T11633 T11631 arg1Of mechanism,a
R9526 T11633 T11632 arg1Of mechanism,common
R9527 T11633 T11634 arg1Of mechanism,of
R9528 T11633 T11637 arg1Of mechanism,in
R9529 T11636 T11634 arg2Of genes,of
R9530 T11636 T11635 arg1Of genes,silencing
R9531 T11638 T11637 arg2Of leukemia,in
R9532 T11643 T11639 arg2Of shown,and
R9533 T11643 T11640 arg2Of shown,has
R9534 T11643 T11641 arg1Of shown,also
R9535 T11643 T11642 arg2Of shown,been
R9536 T11643 T11644 arg1Of shown,for
R9537 T11643 T11653 arg1Of shown,for
R9538 T11644 T11652 arg1Of for,and
R9539 T11646 T11645 arg1Of IRF,another
R9540 T11646 T11647 arg1Of IRF,","
R9541 T11647 T11644 arg2Of ",",for
R9542 T11648 T11647 arg2Of IRF-7,","
R9543 T11648 T11649 arg1Of IRF-7,(
R9544 T11650 T11649 arg2Of 35,(
R9545 T11651 T11649 arg3Of ),(
R9546 T11653 T11652 arg2Of for,and
R9547 T11654 T11653 arg2Of PU.1,for
R9548 T11654 T11655 arg1Of PU.1,(
R9549 T11654 T11658 arg1Of PU.1,","
R9550 T11656 T11655 arg2Of 36,(
R9551 T11657 T11655 arg3Of ),(
R9552 T11661 T11658 arg2Of partner,","
R9553 T11661 T11659 arg1Of partner,an
R9554 T11661 T11660 arg1Of partner,interacting
R9555 T11661 T11662 arg1Of partner,of
R9556 T11663 T11662 arg2Of IRF-4,of
R9557 T11665 T11664 arg1Of elucidate,To
R9558 T11665 T11688 arg1Of elucidate,were
R9559 T11665 T11689 arg2Of elucidate,sequenced
R9560 T11667 T11665 arg2Of relevance,elucidate
R9561 T11667 T11666 arg1Of relevance,the
R9562 T11667 T11668 arg1Of relevance,of
R9563 T11670 T11668 arg2Of mechanism,of
R9564 T11670 T11669 arg1Of mechanism,this
R9565 T11670 T11671 arg1Of mechanism,for
R9566 T11673 T11671 arg2Of regulation,for
R9567 T11673 T11672 arg1Of regulation,the
R9568 T11673 T11674 arg1Of regulation,of
R9569 T11676 T11674 arg2Of expression,of
R9570 T11676 T11675 arg1Of expression,IRF-4
R9571 T11680 T11678 arg1Of cells,various
R9572 T11680 T11679 arg1Of cells,leukemic
R9573 T11680 T11681 arg1Of cells,were
R9574 T11680 T11682 arg2Of cells,treated
R9575 T11682 T11681 arg2Of treated,were
R9576 T11682 T11683 arg1Of treated,with
R9577 T11685 T11686 arg1Of agents,and
R9578 T11686 T11683 arg2Of and,with
R9579 T11686 T11684 arg1Of and,demethylating
R9580 T11687 T11686 arg2Of promoters,and
R9581 T11689 T11677 arg1Of sequenced,","
R9582 T11689 T11681 modOf sequenced,were
R9583 T11689 T11688 arg2Of sequenced,were
R9584 T11689 T11690 arg1Of sequenced,after
R9585 T11692 T11690 arg2Of treatment,after
R9586 T11692 T11691 arg1Of treatment,bisulfite
R9587 T11693 T11694 arg1Of We,found
R9588 T11697 T11696 arg1Of expression,IRF-4
R9589 T11697 T11698 arg1Of expression,could
R9590 T11697 T11700 arg1Of expression,be
R9591 T11697 T11701 arg2Of expression,connected
R9592 T11701 T11694 arg2Of connected,found
R9593 T11701 T11695 arg1Of connected,that
R9594 T11701 T11698 arg2Of connected,could
R9595 T11701 T11699 arg1Of connected,indeed
R9596 T11701 T11700 arg2Of connected,be
R9597 T11701 T11702 arg1Of connected,to
R9598 T11705 T11702 arg2Of status,to
R9599 T11705 T11703 arg1Of status,the
R9600 T11705 T11704 arg1Of status,methylation
R9601 T11705 T11706 arg1Of status,of
R9602 T11709 T11706 arg2Of motifs,of
R9603 T11709 T11707 arg1Of motifs,distinct
R9604 T11709 T11708 arg1Of motifs,CpG
R9605 T11709 T11710 arg1Of motifs,in
R9606 T11713 T11710 arg2Of promoter,in
R9607 T11713 T11711 arg1Of promoter,the
R9608 T11713 T11712 arg1Of promoter,IRF-4
R9609 T11716 T11714 arg2Of 4A,In
R9610 T11716 T11715 arg1Of 4A,Figure
R9611 T11720 T11718 arg1Of sites,those
R9612 T11720 T11719 arg1Of sites,CpG
R9613 T11720 T11721 arg1Of sites,are
R9614 T11720 T11722 arg2Of sites,shown
R9615 T11722 T11714 arg1Of shown,In
R9616 T11722 T11717 arg1Of shown,","
R9617 T11722 T11721 arg2Of shown,are
R9618 T11722 T11723 arg1Of shown,(
R9619 T11722 T11727 arg1Of shown,","
R9620 T11725 T11723 arg2Of line,(
R9621 T11725 T11724 arg1Of line,bottom
R9622 T11726 T11723 arg3Of ),(
R9623 T11728 T11722 arg3Of whose,shown
R9624 T11729 T11728 arg1Of hypermethylation,whose
R9625 T11729 T11730 arg1Of hypermethylation,may
R9626 T11729 T11731 arg1Of hypermethylation,account
R9627 T11731 T11730 arg2Of account,may
R9628 T11731 T11732 arg1Of account,for
R9629 T11734 T11732 arg2Of absence,for
R9630 T11734 T11733 arg1Of absence,the
R9631 T11734 T11735 arg1Of absence,of
R9632 T11737 T11735 arg2Of expression,of
R9633 T11737 T11736 arg1Of expression,IRF-4
R9634 T11737 T11738 arg1Of expression,in
R9635 T11741 T11738 arg2Of cells,in
R9636 T11741 T11739 arg1Of cells,the
R9637 T11741 T11740 arg1Of cells,respective
R9638 T11742 T11743 arg1Of One,of
R9639 T11742 T11749 arg1Of One,is
R9640 T11744 T11743 arg2Of them,of
R9641 T11744 T11745 arg1Of them,(
R9642 T11747 T11745 arg2Of 54,(
R9643 T11747 T11746 arg1Of 54,#
R9644 T11748 T11745 arg3Of ),(
R9645 T11749 T11759 arg1Of is,","
R9646 T11749 T11760 modOf is,indicating
R9647 T11750 T11749 arg2Of adjacent,is
R9648 T11750 T11751 arg1Of adjacent,to
R9649 T11755 T11751 arg2Of element,to
R9650 T11755 T11752 arg1Of element,an
R9651 T11755 T11753 arg2Of element,identified
R9652 T11755 T11754 arg1Of element,regulatory
R9653 T11755 T11756 arg1Of element,(
R9654 T11757 T11756 arg2Of NFκB-site,(
R9655 T11758 T11756 arg3Of ),(
R9656 T11763 T11760 arg2Of involvement,indicating
R9657 T11763 T11761 arg1Of involvement,a
R9658 T11763 T11762 arg1Of involvement,possible
R9659 T11763 T11764 arg1Of involvement,of
R9660 T11766 T11764 arg2Of site,of
R9661 T11766 T11765 arg1Of site,this
R9662 T11771 T11767 arg2Of sites,At
R9663 T11771 T11768 arg1Of sites,two
R9664 T11771 T11769 arg1Of sites,further
R9665 T11771 T11770 arg1Of sites,CpG
R9666 T11771 T11772 arg1Of sites,(
R9667 T11774 T11772 arg2Of 48,(
R9668 T11774 T11773 arg1Of 48,#
R9669 T11774 T11775 arg1Of 48,","
R9670 T11776 T11775 arg2Of 45,","
R9671 T11777 T11772 arg3Of ),(
R9672 T11780 T11778 arg1Of status,the
R9673 T11780 T11779 arg1Of status,methylation
R9674 T11780 T11781 arg1Of status,in
R9675 T11780 T11783 arg1Of status,was
R9676 T11780 T11784 arg1Of status,lower
R9677 T11782 T11781 arg2Of IRF-4-positive,in
R9678 T11783 T11767 arg1Of was,At
R9679 T11784 T11783 arg2Of lower,was
R9680 T11784 T11785 arg1Of lower,than
R9681 T11786 T11785 arg2Of that,than
R9682 T11786 T11787 arg1Of that,of
R9683 T11789 T11787 arg2Of cells,of
R9684 T11789 T11788 arg1Of cells,IRF-4-negative
R9685 T11792 T11790 arg1Of sites,These
R9686 T11792 T11791 arg1Of sites,CpG
R9687 T11792 T11793 arg1Of sites,are
R9688 T11792 T11794 arg1Of sites,located
R9689 T11792 T11807 arg1Of sites,may
R9690 T11792 T11809 arg1Of sites,play
R9691 T11793 T11805 arg1Of are,and
R9692 T11794 T11793 arg2Of located,are
R9693 T11794 T11795 arg1Of located,in
R9694 T11797 T11796 arg1Of NFκB,an
R9695 T11797 T11798 arg1Of NFκB,and
R9696 T11798 T11795 arg2Of and,in
R9697 T11801 T11798 arg2Of element,and
R9698 T11801 T11799 arg1Of element,an
R9699 T11801 T11800 arg1Of element,SP1
R9700 T11801 T11802 arg1Of element,(
R9701 T11803 T11802 arg2Of 31,(
R9702 T11804 T11802 arg3Of ),(
R9703 T11809 T11805 arg2Of play,and
R9704 T11809 T11806 arg1Of play,thus
R9705 T11809 T11807 arg2Of play,may
R9706 T11809 T11808 arg1Of play,also
R9707 T11809 T11812 arg1Of play,in
R9708 T11811 T11809 arg2Of role,play
R9709 T11811 T11810 arg1Of role,a
R9710 T11813 T11812 arg2Of regulation,in
R9711 T11813 T11814 arg1Of regulation,of
R9712 T11816 T11814 arg2Of expression,of
R9713 T11816 T11815 arg1Of expression,IRF-4
R9714 T11817 T11818 arg1Of It,has
R9715 T11817 T11819 arg1Of It,been
R9716 T11817 T11820 arg2Of It,shown
R9717 T11820 T11818 arg2Of shown,has
R9718 T11820 T11819 arg2Of shown,been
R9719 T11823 T11822 arg1Of elements,NFκB
R9720 T11823 T11824 arg1Of elements,play
R9721 T11824 T11820 arg3Of play,shown
R9722 T11824 T11821 arg1Of play,that
R9723 T11824 T11828 arg1Of play,in
R9724 T11824 T11831 arg1Of play,as
R9725 T11827 T11824 arg2Of role,play
R9726 T11827 T11825 arg1Of role,an
R9727 T11827 T11826 arg1Of role,important
R9728 T11830 T11828 arg2Of induction,in
R9729 T11830 T11829 arg1Of induction,IRF-4
R9730 T11833 T11832 arg1Of expression,IRF-4
R9731 T11833 T11834 arg1Of expression,depends
R9732 T11834 T11831 arg2Of depends,as
R9733 T11834 T11835 arg1Of depends,on
R9734 T11836 T11835 arg2Of binding,on
R9735 T11836 T11837 arg1Of binding,of
R9736 T11836 T11841 arg1Of binding,to
R9737 T11840 T11837 arg2Of c-Rel,of
R9738 T11840 T11838 arg1Of c-Rel,the
R9739 T11840 T11839 arg1Of c-Rel,transactivator
R9740 T11843 T11841 arg2Of elements,to
R9741 T11843 T11842 arg1Of elements,these
R9742 T11843 T11844 arg1Of elements,in
R9743 T11847 T11844 arg2Of promoter,in
R9744 T11847 T11845 arg1Of promoter,the
R9745 T11847 T11846 arg1Of promoter,IRF-4
R9746 T11847 T11848 arg1Of promoter,(
R9747 T11849 T11848 arg2Of "31,37",(
R9748 T11850 T11848 arg3Of ),(
R9749 T11853 T11854 arg1Of methylation,of
R9750 T11853 T11862 arg1Of methylation,inhibits
R9751 T11857 T11854 arg2Of CpG,of
R9752 T11857 T11855 arg1Of CpG,the
R9753 T11857 T11856 arg1Of CpG,central
R9754 T11857 T11858 arg1Of CpG,in
R9755 T11861 T11858 arg2Of element,in
R9756 T11861 T11859 arg1Of element,the
R9757 T11861 T11860 arg1Of element,NFκB
R9758 T11862 T11851 arg1Of inhibits,Furthermore
R9759 T11862 T11852 arg1Of inhibits,","
R9760 T11862 T11872 arg1Of inhibits,","
R9761 T11863 T11862 arg2Of binding,inhibits
R9762 T11863 T11864 arg1Of binding,of
R9763 T11868 T11864 arg2Of complexes,of
R9764 T11868 T11865 arg1Of complexes,the
R9765 T11868 T11866 arg1Of complexes,NFκB
R9766 T11868 T11867 arg1Of complexes,protein
R9767 T11868 T11869 arg1Of complexes,(
R9768 T11870 T11869 arg2Of 38,(
R9769 T11871 T11869 arg3Of ),(
R9770 T11873 T11862 arg3Of promoting,inhibits
R9771 T11875 T11873 arg2Of significance,promoting
R9772 T11875 T11874 arg1Of significance,the
R9773 T11875 T11876 arg1Of significance,of
R9774 T11880 T11876 arg2Of differences,of
R9775 T11880 T11877 arg1Of differences,the
R9776 T11880 T11878 arg2Of differences,observed
R9777 T11880 T11879 arg1Of differences,methylation
R9778 T11880 T11881 arg1Of differences,in
R9779 T11882 T11883 arg1Of IRF-4-positive,and
R9780 T11884 T11883 arg2Of -negative,and
R9781 T11885 T11881 arg2Of cells,in
R9782 T11885 T11882 arg1Of cells,IRF-4-positive
R9783 T11885 T11884 arg1Of cells,-negative
R9784 T11888 T11887 arg1Of vitro,in
R9785 T11889 T11890 arg1Of methylation,and
R9786 T11891 T11890 arg2Of reporter,and
R9787 T11893 T11886 arg2Of assays,Via
R9788 T11893 T11888 arg1Of assays,vitro
R9789 T11893 T11889 arg1Of assays,methylation
R9790 T11893 T11891 arg1Of assays,reporter
R9791 T11893 T11892 arg1Of assays,gene
R9792 T11894 T11895 arg1Of we,could
R9793 T11894 T11897 arg1Of we,appoint
R9794 T11897 T11886 modOf appoint,Via
R9795 T11897 T11895 arg2Of appoint,could
R9796 T11897 T11896 arg1Of appoint,clearly
R9797 T11897 T11904 arg1Of appoint,to
R9798 T11899 T11897 arg2Of silencing,appoint
R9799 T11899 T11898 arg1Of silencing,the
R9800 T11899 T11900 arg1Of silencing,of
R9801 T11903 T11900 arg2Of promoter,of
R9802 T11903 T11901 arg1Of promoter,the
R9803 T11903 T11902 arg1Of promoter,IRF-4
R9804 T11907 T11904 arg2Of effect,to
R9805 T11907 T11905 arg1Of effect,a
R9806 T11907 T11906 arg1Of effect,methylation
R9807 T11907 T11908 arg1Of effect,","
R9808 T11907 T11909 arg1Of effect,which
R9809 T11907 T11910 arg1Of effect,may
R9810 T11907 T11912 arg1Of effect,be
R9811 T11912 T11910 arg2Of be,may
R9812 T11912 T11911 arg1Of be,thus
R9813 T11912 T11919 arg1Of be,vivo
R9814 T11914 T11912 arg2Of mechanism,be
R9815 T11914 T11913 arg1Of mechanism,the
R9816 T11914 T11915 arg1Of mechanism,of
R9817 T11917 T11915 arg2Of deregulation,of
R9818 T11917 T11916 arg1Of deregulation,IRF-4
R9819 T11919 T11918 arg1Of vivo,in
R9820 T11922 T11920 arg1Of cause,One
R9821 T11922 T11921 arg1Of cause,possible
R9822 T11922 T11923 arg1Of cause,for
R9823 T11922 T11929 arg1Of cause,is
R9824 T11926 T11923 arg2Of methylation,for
R9825 T11926 T11924 arg1Of methylation,the
R9826 T11926 T11925 arg1Of methylation,aberrant
R9827 T11926 T11927 arg1Of methylation,in
R9828 T11928 T11927 arg2Of tumorigenesis,in
R9829 T11932 T11929 arg2Of level,is
R9830 T11932 T11930 arg1Of level,an
R9831 T11932 T11931 arg2Of level,increased
R9832 T11932 T11933 arg1Of level,of
R9833 T11932 T11935 arg1Of level,during
R9834 T11934 T11933 arg2Of DNMTs,of
R9835 T11938 T11935 arg2Of process,during
R9836 T11938 T11936 arg1Of process,the
R9837 T11938 T11937 arg1Of process,pathogenetic
R9838 T11940 T11941 arg1Of colon,","
R9839 T11941 T11943 arg1Of ",",and
R9840 T11942 T11941 arg2Of lung,","
R9841 T11943 T11939 arg2Of and,In
R9842 T11945 T11943 arg2Of malignancies,and
R9843 T11945 T11944 arg1Of malignancies,hematologic
R9844 T11947 T11948 arg1Of overexpression,of
R9845 T11947 T11955 arg1Of overexpression,has
R9846 T11947 T11956 arg1Of overexpression,been
R9847 T11947 T11957 arg2Of overexpression,detected
R9848 T11949 T11948 arg2Of DNMT1,of
R9849 T11949 T11950 arg1Of DNMT1,","
R9850 T11953 T11950 arg2Of DNMT,","
R9851 T11953 T11951 arg1Of DNMT,a
R9852 T11953 T11952 arg1Of DNMT,maintenance
R9853 T11957 T11939 arg1Of detected,In
R9854 T11957 T11946 arg1Of detected,","
R9855 T11957 T11954 arg1Of detected,","
R9856 T11957 T11955 arg2Of detected,has
R9857 T11957 T11956 arg2Of detected,been
R9858 T11957 T11958 arg1Of detected,(
R9859 T11959 T11958 arg2Of 39–41,(
R9860 T11960 T11958 arg3Of ),(
R9861 T11963 T11964 arg1Of it,has
R9862 T11963 T11965 arg1Of it,been
R9863 T11963 T11966 arg2Of it,shown
R9864 T11966 T11961 arg1Of shown,Furthermore
R9865 T11966 T11962 arg1Of shown,","
R9866 T11966 T11964 arg2Of shown,has
R9867 T11966 T11965 arg2Of shown,been
R9868 T11969 T11968 arg1Of cells,CML
R9869 T11969 T11970 arg1Of cells,in
R9870 T11969 T11974 arg1Of cells,exhibited
R9871 T11973 T11970 arg2Of phase,in
R9872 T11973 T11971 arg1Of phase,the
R9873 T11973 T11972 arg1Of phase,acute
R9874 T11974 T11966 arg3Of exhibited,shown
R9875 T11974 T11967 arg1Of exhibited,that
R9876 T11974 T11982 arg1Of exhibited,","
R9877 T11974 T11983 arg1Of exhibited,while
R9878 T11976 T11974 arg2Of levels,exhibited
R9879 T11976 T11975 arg1Of levels,elevated
R9880 T11976 T11977 arg1Of levels,of
R9881 T11981 T11977 arg2Of DNMTs,of
R9882 T11981 T11978 arg1Of DNMTs,the
R9883 T11981 T11979 arg1Of DNMTs,three
R9884 T11981 T11980 arg2Of DNMTs,known
R9885 T11985 T11984 arg1Of cells,CML
R9886 T11985 T11986 arg1Of cells,in
R9887 T11985 T11989 arg1Of cells,expressed
R9888 T11988 T11986 arg2Of phase,in
R9889 T11988 T11987 arg1Of phase,chronic
R9890 T11989 T11983 arg2Of expressed,while
R9891 T11989 T11994 arg1Of expressed,if
R9892 T11991 T11989 arg2Of levels,expressed
R9893 T11991 T11990 arg1Of levels,normal
R9894 T11991 T11992 arg1Of levels,of
R9895 T11993 T11992 arg2Of DNMTs,of
R9896 T11995 T11994 arg2Of compared,if
R9897 T11995 T11996 arg1Of compared,with
R9898 T12000 T11996 arg2Of cells,with
R9899 T12000 T11997 arg1Of cells,normal
R9900 T12000 T11998 arg1Of cells,bone
R9901 T12000 T11999 arg1Of cells,marrow
R9902 T12000 T12001 arg1Of cells,(
R9903 T12002 T12001 arg2Of 25,(
R9904 T12003 T12001 arg3Of ),(
R9905 T12008 T12006 arg1Of correlation,a
R9906 T12008 T12007 arg1Of correlation,positive
R9907 T12008 T12009 arg1Of correlation,between
R9908 T12008 T12017 arg1Of correlation,has
R9909 T12008 T12018 arg1Of correlation,been
R9910 T12008 T12019 arg2Of correlation,detected
R9911 T12012 T12010 arg1Of levels,DNMT1
R9912 T12012 T12011 arg1Of levels,expression
R9913 T12012 T12013 arg1Of levels,and
R9914 T12013 T12009 arg2Of and,between
R9915 T12014 T12013 arg2Of hypermethylation,and
R9916 T12014 T12015 arg1Of hypermethylation,of
R9917 T12016 T12015 arg2Of p15INK4b,of
R9918 T12019 T12004 arg1Of detected,Interestingly
R9919 T12019 T12005 arg1Of detected,","
R9920 T12019 T12017 arg2Of detected,has
R9921 T12019 T12018 arg2Of detected,been
R9922 T12019 T12020 arg1Of detected,in
R9923 T12021 T12020 arg2Of AML,in
R9924 T12021 T12022 arg1Of AML,(
R9925 T12023 T12022 arg2Of 25,(
R9926 T12024 T12022 arg3Of ),(
R9927 T12027 T12025 arg2Of work,In
R9928 T12027 T12026 arg1Of work,this
R9929 T12029 T12030 arg1Of we,did
R9930 T12029 T12032 arg1Of we,detect
R9931 T12032 T12025 arg1Of detect,In
R9932 T12032 T12028 arg1Of detect,","
R9933 T12032 T12030 arg2Of detect,did
R9934 T12032 T12031 arg1Of detect,not
R9935 T12032 T12042 arg1Of detect,","
R9936 T12032 T12043 modOf detect,making
R9937 T12036 T12032 arg2Of differences,detect
R9938 T12036 T12033 arg1Of differences,significant
R9939 T12036 T12034 arg1Of differences,mRNA
R9940 T12036 T12035 arg1Of differences,expression
R9941 T12036 T12037 arg1Of differences,of
R9942 T12039 T12040 arg1Of DNMT,or
R9943 T12040 T12037 arg2Of or,of
R9944 T12040 T12038 arg2Of or,selected
R9945 T12041 T12040 arg2Of MBP,or
R9946 T12044 T12043 arg2Of it,making
R9947 T12047 T12043 arg3Of cause,making
R9948 T12047 T12045 arg1Of cause,an
R9949 T12047 T12046 arg1Of cause,unlikely
R9950 T12047 T12048 arg1Of cause,for
R9951 T12051 T12050 arg2Of methylation,observed
R9952 T12051 T12052 arg1Of methylation,and
R9953 T12052 T12048 arg2Of and,for
R9954 T12052 T12049 arg1Of and,the
R9955 T12052 T12057 arg1Of and,in
R9956 T12056 T12052 arg2Of differences,and
R9957 T12056 T12053 arg1Of differences,thus
R9958 T12056 T12054 arg1Of differences,IRF-4
R9959 T12056 T12055 arg1Of differences,expression
R9960 T12059 T12057 arg2Of cells,in
R9961 T12059 T12058 arg1Of cells,leukemia
R9962 T12061 T12060 arg1Of finding,The
R9963 T12061 T12070 arg1Of finding,might
R9964 T12061 T12071 arg1Of finding,represent
R9965 T12064 T12063 arg1Of expression,IRF-4
R9966 T12064 T12065 arg1Of expression,is
R9967 T12064 T12066 arg2Of expression,silenced
R9968 T12066 T12061 arg2Of silenced,finding
R9969 T12066 T12062 arg1Of silenced,that
R9970 T12066 T12065 arg2Of silenced,is
R9971 T12069 T12066 arg1Of hypermethylation,silenced
R9972 T12069 T12067 arg2Of hypermethylation,by
R9973 T12069 T12068 arg1Of hypermethylation,promoter
R9974 T12071 T12070 arg2Of represent,might
R9975 T12073 T12071 arg2Of mechanism,represent
R9976 T12073 T12072 arg1Of mechanism,a
R9977 T12073 T12074 arg1Of mechanism,that
R9978 T12073 T12075 arg1Of mechanism,accounts
R9979 T12075 T12076 arg1Of accounts,for
R9980 T12079 T12078 arg1Of observed,previously
R9981 T12080 T12076 arg2Of loss,for
R9982 T12080 T12077 arg1Of loss,the
R9983 T12080 T12079 arg1Of loss,observed
R9984 T12080 T12081 arg1Of loss,of
R9985 T12083 T12081 arg2Of expression,of
R9986 T12083 T12082 arg1Of expression,IRF-4
R9987 T12083 T12084 arg1Of expression,in
R9988 T12085 T12084 arg2Of CML,in
R9989 T12090 T12088 arg1Of trials,several
R9990 T12090 T12089 arg1Of trials,clinical
R9991 T12090 T12091 arg1Of trials,with
R9992 T12090 T12099 arg1Of trials,demonstrated
R9993 T12093 T12092 arg1Of patients,leukemia
R9994 T12093 T12094 arg1Of patients,and
R9995 T12094 T12091 arg2Of and,with
R9996 T12095 T12094 arg2Of patients,and
R9997 T12095 T12096 arg1Of patients,with
R9998 T12098 T12096 arg2Of syndromes,with
R9999 T12098 T12097 arg1Of syndromes,myelodysplastic
R10000 T12099 T12086 arg1Of demonstrated,Indeed
R10001 T12099 T12087 arg1Of demonstrated,","
R10002 T12103 T12099 arg2Of benefit,demonstrated
R10003 T12103 T12100 arg1Of benefit,the
R10004 T12103 T12101 arg1Of benefit,potential
R10005 T12103 T12102 arg1Of benefit,clinical
R10006 T12103 T12104 arg1Of benefit,of
R10007 T12106 T12104 arg2Of treatment,of
R10008 T12106 T12105 arg1Of treatment,a
R10009 T12106 T12107 arg1Of treatment,with
R10010 T12109 T12107 arg2Of agents,with
R10011 T12109 T12108 arg1Of agents,demethylating
R10012 T12109 T12110 arg1Of agents,(
R10013 T12111 T12110 arg2Of 42–45,(
R10014 T12112 T12110 arg3Of ),(
R10015 T12114 T12113 arg1Of expression,The
R10016 T12114 T12115 arg1Of expression,of
R10017 T12114 T12128 arg1Of expression,is
R10018 T12114 T12129 arg1Of expression,impaired
R10019 T12117 T12116 arg1Of IRF,another
R10020 T12117 T12118 arg1Of IRF,","
R10021 T12118 T12115 arg2Of ",",of
R10022 T12123 T12118 arg2Of protein,","
R10023 T12123 T12119 arg1Of protein,IFN
R10024 T12123 T12120 arg1Of protein,consensus
R10025 T12123 T12121 arg1Of protein,sequence
R10026 T12123 T12122 arg1Of protein,binding
R10027 T12123 T12124 arg1Of protein,(
R10028 T12125 T12124 arg2Of ICSBP/IRF-8,(
R10029 T12126 T12124 arg3Of ),(
R10030 T12128 T12127 arg1Of is,","
R10031 T12129 T12128 arg2Of impaired,is
R10032 T12129 T12130 arg1Of impaired,in
R10033 T12134 T12130 arg2Of CML,in
R10034 T12134 T12131 arg1Of CML,myeloid
R10035 T12134 T12132 arg1Of CML,leukemias
R10036 T12134 T12133 arg1Of CML,especially
R10037 T12134 T12135 arg1Of CML,(
R10038 T12136 T12135 arg2Of "27,46,47",(
R10039 T12137 T12135 arg3Of ),(
R10040 T12140 T12139 arg2Of contrast,in
R10041 T12140 T12141 arg1Of contrast,to
R10042 T12142 T12141 arg2Of IRF-4,to
R10043 T12145 T12144 arg1Of loss,the
R10044 T12145 T12146 arg1Of loss,of
R10045 T12145 T12149 arg1Of loss,could
R10046 T12145 T12151 arg1Of loss,be
R10047 T12145 T12152 arg2Of loss,reverted
R10048 T12148 T12146 arg2Of IRF,of
R10049 T12148 T12147 arg1Of IRF,this
R10050 T12152 T12149 arg2Of reverted,could
R10051 T12152 T12150 arg1Of reverted,not
R10052 T12152 T12151 arg2Of reverted,be
R10053 T12152 T12153 arg1Of reverted,in
R10054 T12152 T12166 arg1Of reverted,by
R10055 T12152 T12174 arg1Of reverted,and
R10056 T12156 T12153 arg2Of lines,in
R10057 T12156 T12154 arg1Of lines,ICSBP-negative
R10058 T12156 T12155 arg1Of lines,cell
R10059 T12156 T12157 arg1Of lines,(
R10060 T12158 T12159 arg1Of EM-2,","
R10061 T12159 T12161 arg1Of ",",","
R10062 T12160 T12159 arg2Of CML-T1,","
R10063 T12161 T12163 arg1Of ",",and
R10064 T12162 T12161 arg2Of K-562,","
R10065 T12163 T12157 arg2Of and,(
R10066 T12164 T12163 arg2Of LAMA-84,and
R10067 T12165 T12157 arg3Of ),(
R10068 T12167 T12166 arg2Of treatment,by
R10069 T12167 T12168 arg1Of treatment,with
R10070 T12169 T12168 arg2Of AzadC,with
R10071 T12169 T12170 arg1Of AzadC,(
R10072 T12171 T12170 arg2Of Figure,(
R10073 T12171 T12172 arg1Of Figure,6
R10074 T12173 T12170 arg3Of ),(
R10075 T12174 T12138 arg1Of and,But
R10076 T12174 T12139 arg1Of and,in
R10077 T12174 T12143 arg1Of and,","
R10078 T12175 T12176 arg1Of AzadC,has
R10079 T12176 T12174 arg2Of has,and
R10080 T12176 T12179 arg1Of has,on
R10081 T12178 T12176 arg2Of effect,has
R10082 T12178 T12177 arg1Of effect,no
R10083 T12181 T12179 arg2Of levels,on
R10084 T12181 T12180 arg1Of levels,ICSBP
R10085 T12181 T12182 arg1Of levels,in
R10086 T12185 T12182 arg2Of cells,in
R10087 T12185 T12183 arg1Of cells,ICSBP-positive
R10088 T12185 T12184 arg1Of cells,U-937
R10089 T12185 T12186 arg1Of cells,(
R10090 T12187 T12186 arg2Of Figure,(
R10091 T12187 T12188 arg1Of Figure,6
R10092 T12189 T12186 arg3Of ),(
R10093 T12191 T12190 arg1Of data,These
R10094 T12191 T12192 arg1Of data,suggest
R10095 T12196 T12192 arg2Of mechanism,suggest
R10096 T12196 T12193 arg1Of mechanism,a
R10097 T12196 T12194 arg1Of mechanism,distinct
R10098 T12196 T12195 arg1Of mechanism,regulatory
R10099 T12196 T12197 arg1Of mechanism,for
R10100 T12200 T12197 arg2Of IRFs,for
R10101 T12200 T12198 arg1Of IRFs,these
R10102 T12200 T12199 arg1Of IRFs,two
R10103 T12201 T12202 arg1Of IRF-4,","
R10104 T12201 T12203 arg1Of IRF-4,similar
R10105 T12203 T12204 arg1Of similar,to
R10106 T12210 T12204 arg2Of genes,to
R10107 T12210 T12205 arg1Of genes,many
R10108 T12210 T12206 arg1Of genes,other
R10109 T12210 T12207 arg1Of genes,classical
R10110 T12210 T12208 arg1Of genes,tumor
R10111 T12210 T12209 arg1Of genes,suppressor
R10112 T12211 T12212 arg1Of p15INK4b,","
R10113 T12212 T12214 arg1Of ",",or
R10114 T12213 T12212 arg2Of p16INK4a,","
R10115 T12214 T12201 arg1Of or,IRF-4
R10116 T12214 T12217 arg1Of or,may
R10117 T12214 T12219 arg1Of or,be
R10118 T12215 T12214 arg2Of p53,or
R10119 T12219 T12216 arg1Of be,","
R10120 T12219 T12217 arg2Of be,may
R10121 T12219 T12218 arg1Of be,thus
R10122 T12221 T12219 arg2Of subject,be
R10123 T12221 T12220 arg1Of subject,a
R10124 T12221 T12222 arg1Of subject,of
R10125 T12221 T12224 arg1Of subject,in
R10126 T12221 T12233 arg1Of subject,","
R10127 T12221 T12234 arg1Of subject,which
R10128 T12221 T12235 arg1Of subject,might
R10129 T12221 T12236 arg1Of subject,contribute
R10130 T12223 T12222 arg2Of alterations,of
R10131 T12228 T12224 arg2Of status,in
R10132 T12228 T12225 arg1Of status,the
R10133 T12228 T12226 arg1Of status,promoter
R10134 T12228 T12227 arg1Of status,methylation
R10135 T12228 T12229 arg1Of status,leading
R10136 T12229 T12230 arg1Of leading,to
R10137 T12232 T12230 arg2Of changes,to
R10138 T12232 T12231 arg1Of changes,expression
R10139 T12236 T12235 arg2Of contribute,might
R10140 T12236 T12237 arg1Of contribute,to
R10141 T12239 T12240 arg1Of initiation,and/or
R10142 T12240 T12237 arg2Of and/or,to
R10143 T12240 T12238 arg1Of and/or,the
R10144 T12240 T12242 arg1Of and/or,of
R10145 T12241 T12240 arg2Of progression,and/or
R10146 T12243 T12242 arg2Of cancer,of
R10147 T12249 T12246 arg1Of diversity,the
R10148 T12249 T12247 arg1Of diversity,obvious
R10149 T12249 T12248 arg1Of diversity,functional
R10150 T12249 T12250 arg1Of diversity,of
R10151 T12249 T12252 arg1Of diversity,remains
R10152 T12249 T12253 arg1Of diversity,remarkable
R10153 T12249 T12255 arg1Of diversity,can
R10154 T12249 T12257 arg1Of diversity,be
R10155 T12249 T12259 arg2Of diversity,explained
R10156 T12251 T12250 arg2Of IRF-4,of
R10157 T12252 T12254 arg1Of remains,and
R10158 T12253 T12252 arg2Of remarkable,remains
R10159 T12254 T12244 arg1Of and,Still
R10160 T12254 T12245 arg1Of and,","
R10161 T12259 T12254 arg2Of explained,and
R10162 T12259 T12255 arg2Of explained,can
R10163 T12259 T12256 arg1Of explained,not
R10164 T12259 T12257 arg2Of explained,be
R10165 T12259 T12258 arg1Of explained,fully
R10166 T12265 T12259 arg1Of status,explained
R10167 T12265 T12260 arg2Of status,by
R10168 T12265 T12261 arg1Of status,the
R10169 T12265 T12262 arg1Of status,IRF-4
R10170 T12265 T12263 arg1Of status,promoter
R10171 T12265 T12264 arg1Of status,methylation
R10172 T12267 T12266 arg2Of example,For
R10173 T12269 T12270 arg1Of IRF-4,is
R10174 T12269 T12272 arg2Of IRF-4,known
R10175 T12272 T12266 arg1Of known,For
R10176 T12272 T12268 arg1Of known,","
R10177 T12272 T12270 arg2Of known,is
R10178 T12272 T12271 arg1Of known,primarily
R10179 T12272 T12273 arg1Of known,for
R10180 T12276 T12273 arg2Of features,for
R10181 T12276 T12274 arg1Of features,its
R10182 T12276 T12275 arg1Of features,oncogenic
R10183 T12279 T12277 arg2Of myeloma,In
R10184 T12279 T12278 arg1Of myeloma,multiple
R10185 T12279 T12280 arg1Of myeloma,(
R10186 T12281 T12280 arg2Of MM,(
R10187 T12282 T12280 arg3Of ),(
R10188 T12284 T12283 arg1Of translocation,a
R10189 T12284 T12285 arg1Of translocation,on
R10190 T12284 T12288 arg1Of translocation,was
R10191 T12284 T12289 arg2Of translocation,reported
R10192 T12284 T12291 arg1Of translocation,lead
R10193 T12287 T12285 arg2Of 14q,on
R10194 T12287 T12286 arg1Of 14q,chromosome
R10195 T12289 T12277 arg1Of reported,In
R10196 T12289 T12288 arg2Of reported,was
R10197 T12289 T12304 modOf reported,resulting
R10198 T12291 T12289 arg3Of lead,reported
R10199 T12291 T12290 arg1Of lead,to
R10200 T12291 T12292 arg1Of lead,to
R10201 T12295 T12292 arg2Of gene,to
R10202 T12295 T12293 arg1Of gene,a
R10203 T12295 T12294 arg1Of gene,fusion
R10204 T12295 T12296 arg1Of gene,of
R10205 T12298 T12297 arg1Of heavy-chain,immunoglobulin
R10206 T12298 T12299 arg1Of heavy-chain,(
R10207 T12298 T12302 arg1Of heavy-chain,and
R10208 T12300 T12299 arg2Of IgH,(
R10209 T12301 T12299 arg3Of ),(
R10210 T12302 T12296 arg2Of and,of
R10211 T12303 T12302 arg2Of IRF-4,and
R10212 T12304 T12305 arg1Of resulting,in
R10213 T12308 T12305 arg2Of overexpression,in
R10214 T12308 T12306 arg1Of overexpression,a
R10215 T12308 T12307 arg1Of overexpression,subsequent
R10216 T12308 T12309 arg1Of overexpression,of
R10217 T12310 T12309 arg2Of IRF-4,of
R10218 T12310 T12311 arg1Of IRF-4,(
R10219 T12312 T12311 arg2Of "48,49",(
R10220 T12313 T12311 arg3Of ),(
R10221 T12315 T12314 arg2Of addition,In
R10222 T12319 T12317 arg1Of expression,abundant
R10223 T12319 T12318 arg1Of expression,IRF-4
R10224 T12319 T12320 arg1Of expression,was
R10225 T12319 T12321 arg2Of expression,found
R10226 T12319 T12323 arg1Of expression,be
R10227 T12321 T12314 arg1Of found,In
R10228 T12321 T12316 arg1Of found,","
R10229 T12321 T12320 arg2Of found,was
R10230 T12323 T12321 arg3Of be,found
R10231 T12323 T12322 arg1Of be,to
R10232 T12325 T12323 arg2Of marker,be
R10233 T12325 T12324 arg1Of marker,a
R10234 T12325 T12326 arg1Of marker,for
R10235 T12328 T12326 arg2Of subsets,for
R10236 T12328 T12327 arg1Of subsets,various
R10237 T12328 T12329 arg1Of subsets,of
R10238 T12328 T12331 arg1Of subsets,","
R10239 T12328 T12333 arg1Of subsets,as
R10240 T12330 T12329 arg2Of lymphomas,of
R10241 T12333 T12332 arg1Of as,such
R10242 T12337 T12334 arg1Of lymphomas,diffuse
R10243 T12337 T12335 arg1Of lymphomas,large
R10244 T12337 T12336 arg1Of lymphomas,B-cell
R10245 T12337 T12338 arg1Of lymphomas,","
R10246 T12338 T12343 arg1Of ",",and
R10247 T12341 T12338 arg2Of lymphoma,","
R10248 T12341 T12339 arg1Of lymphoma,primary
R10249 T12341 T12340 arg1Of lymphoma,effusion
R10250 T12343 T12342 arg1Of and,","
R10251 T12343 T12348 arg1Of and,and
R10252 T12346 T12343 arg2Of lymphoma,and
R10253 T12346 T12344 arg1Of lymphoma,marginal
R10254 T12346 T12345 arg1Of lymphoma,zone
R10255 T12348 T12333 arg2Of and,as
R10256 T12348 T12347 arg1Of and,","
R10257 T12351 T12348 arg2Of leukemia,and
R10258 T12351 T12349 arg1Of leukemia,adult
R10259 T12351 T12350 arg1Of leukemia,T-cell
R10260 T12351 T12352 arg1Of leukemia,(
R10261 T12353 T12352 arg2Of "11,31,50–52",(
R10262 T12354 T12352 arg3Of ),(
R10263 T12355 T12356 arg1Of This,draws
R10264 T12359 T12358 arg1Of complex,more
R10265 T12360 T12356 arg2Of picture,draws
R10266 T12360 T12357 arg1Of picture,a
R10267 T12360 T12359 arg1Of picture,complex
R10268 T12360 T12361 arg1Of picture,of
R10269 T12363 T12361 arg2Of role,of
R10270 T12363 T12362 arg1Of role,the
R10271 T12363 T12364 arg1Of role,of
R10272 T12365 T12364 arg2Of IRF-4,of
R10273 T12366 T12367 arg1Of Down-regulation,of
R10274 T12366 T12369 arg1Of Down-regulation,may
R10275 T12366 T12370 arg1Of Down-regulation,promote
R10276 T12368 T12367 arg2Of IRF-4,of
R10277 T12370 T12369 arg2Of promote,may
R10278 T12370 T12372 arg1Of promote,in
R10279 T12371 T12370 arg2Of leukemogenesis,promote
R10280 T12375 T12372 arg2Of context,in
R10281 T12375 T12373 arg1Of context,myeloid
R10282 T12375 T12374 arg1Of context,cell
R10283 T12375 T12376 arg1Of context,(
R10284 T12375 T12379 arg1Of context,","
R10285 T12375 T12380 arg1Of context,which
R10286 T12375 T12381 arg1Of context,was
R10287 T12375 T12383 arg2Of context,confirmed
R10288 T12377 T12376 arg2Of 3,(
R10289 T12378 T12376 arg3Of ),(
R10290 T12383 T12381 arg2Of confirmed,was
R10291 T12383 T12382 arg1Of confirmed,recently
R10292 T12383 T12384 arg1Of confirmed,in
R10293 T12383 T12393 arg1Of confirmed,","
R10294 T12383 T12394 arg1Of confirmed,while
R10295 T12389 T12384 arg2Of mice,in
R10296 T12389 T12385 arg1Of mice,IRF-4−/−
R10297 T12389 T12386 arg1Of mice,ICSBP−/−
R10298 T12389 T12387 arg1Of mice,double
R10299 T12389 T12388 arg1Of mice,knock-out
R10300 T12389 T12390 arg1Of mice,(
R10301 T12391 T12390 arg2Of 53,(
R10302 T12392 T12390 arg3Of ),(
R10303 T12396 T12395 arg1Of up-regulation,IRF-4
R10304 T12396 T12397 arg1Of up-regulation,may
R10305 T12396 T12398 arg1Of up-regulation,induce
R10306 T12398 T12394 arg2Of induce,while
R10307 T12398 T12397 arg2Of induce,may
R10308 T12398 T12402 arg1Of induce,in
R10309 T12401 T12398 arg2Of advantage,induce
R10310 T12401 T12399 arg1Of advantage,a
R10311 T12401 T12400 arg1Of advantage,growth
R10312 T12403 T12404 arg1Of lymphomas,or
R10313 T12404 T12402 arg2Of or,in
R10314 T12405 T12404 arg2Of MM,or
R10315 T12405 T12406 arg1Of MM,(
R10316 T12407 T12406 arg2Of 48,(
R10317 T12408 T12406 arg3Of ),(
R10318 T12409 T12410 arg1Of Taken,together
R10319 T12413 T12412 arg1Of data,our
R10320 T12413 T12414 arg1Of data,suggest
R10321 T12414 T12409 modOf suggest,Taken
R10322 T12414 T12411 arg1Of suggest,","
R10323 T12418 T12416 arg1Of methylation,IRF-4
R10324 T12418 T12417 arg1Of methylation,promoter
R10325 T12418 T12419 arg1Of methylation,regulates
R10326 T12419 T12415 arg1Of regulates,that
R10327 T12419 T12423 arg1Of regulates,and
R10328 T12421 T12419 arg2Of expression,regulates
R10329 T12421 T12420 arg1Of expression,IRF-4
R10330 T12423 T12414 arg2Of and,suggest
R10331 T12423 T12422 arg1Of and,","
R10332 T12424 T12423 arg2Of that,and
R10333 T12426 T12425 arg1Of expression,aberrant
R10334 T12426 T12427 arg1Of expression,of
R10335 T12426 T12429 arg1Of expression,in
R10336 T12426 T12434 arg1Of expression,may
R10337 T12426 T12435 arg1Of expression,be
R10338 T12428 T12427 arg2Of IRF-4,of
R10339 T12431 T12429 arg2Of types,in
R10340 T12431 T12430 arg1Of types,certain
R10341 T12431 T12432 arg1Of types,of
R10342 T12433 T12432 arg2Of leukemia,of
R10343 T12435 T12424 arg2Of be,that
R10344 T12435 T12434 arg2Of be,may
R10345 T12437 T12435 arg2Of consequence,be
R10346 T12437 T12436 arg1Of consequence,a
R10347 T12437 T12438 arg1Of consequence,of
R10348 T12441 T12438 arg2Of hypermethylation,of
R10349 T12441 T12439 arg1Of hypermethylation,IRF-4
R10350 T12441 T12440 arg1Of hypermethylation,promoter

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T12442 2987-3001 Anaphor denotes these elements
T12443 2861-2874 Antecedent denotes NFκB elements
T12444 4831-4839 Anaphor denotes this IRF
T12445 4679-4717 Antecedent denotes IFN consensus sequence binding protein
R10351 T12442 T12443 boundBy these elements,NFκB elements
R10352 T12444 T12445 boundBy this IRF,IFN consensus sequence binding protein

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T12531 11-15 JJ denotes Many
T12532 16-23 JJ denotes genetic
T12533 24-31 NNS denotes lesions
T12534 32-35 VBP denotes are
T12535 36-41 VBN denotes known
T12536 42-44 TO denotes to
T12537 45-54 VB denotes influence
T12538 55-59 NN denotes gene
T12539 60-70 NN denotes expression
T12540 71-73 IN denotes of
T12541 74-79 NN denotes tumor
T12542 80-90 NN denotes suppressor
T12543 91-96 NNS denotes genes
T12544 96-97 . denotes .
T12545 98-105 IN denotes Whereas
T12546 106-115 NNS denotes mutations
T12547 116-119 CC denotes and
T12548 120-129 NNS denotes deletions
T12549 130-132 CC denotes or
T12550 133-143 NNS denotes insertions
T12551 144-148 VBP denotes have
T12552 149-158 JJ denotes permanent
T12553 159-166 NNS denotes effects
T12554 166-167 , denotes ,
T12555 168-178 JJ denotes reversible
T12556 179-189 NNS denotes mechanisms
T12557 190-193 VBP denotes are
T12558 194-198 NN denotes gene
T12559 199-210 NN denotes methylation
T12560 210-211 , denotes ,
T12561 212-214 CC denotes or
T12562 215-225 NN denotes expression
T12563 226-229 CC denotes and
T12564 230-240 NN denotes activation
T12565 241-243 IN denotes of
T12566 244-257 NN denotes transcription
T12567 258-265 NNS denotes factors
T12568 265-266 , denotes ,
T12569 267-279 RB denotes respectively
T12570 279-280 . denotes .
T12571 281-283 PRP denotes We
T12572 284-291 VBD denotes studied
T12573 292-293 DT denotes a
T12574 294-302 JJ denotes putative
T12575 303-308 NN denotes cause
T12576 309-312 IN denotes for
T12577 313-319 JJ denotes absent
T12578 320-325 NN denotes IRF-4
T12579 326-336 NN denotes expression
T12580 337-339 IN denotes in
T12581 340-348 NN denotes leukemia
T12582 349-354 NNS denotes cells
T12583 355-358 CC denotes and
T12584 359-364 JJ denotes first
T12585 365-372 VBN denotes focused
T12586 373-375 IN denotes on
T12587 376-383 JJ denotes genetic
T12588 384-395 NNS denotes aberrations
T12589 396-398 IN denotes of
T12590 399-402 DT denotes the
T12591 403-411 NN denotes promoter
T12592 411-412 . denotes .
T12593 413-415 PRP denotes We
T12594 416-424 VBD denotes observed
T12595 425-427 DT denotes no
T12596 428-435 JJ denotes genetic
T12597 436-447 NNS denotes alterations
T12598 448-450 IN denotes in
T12599 451-454 DT denotes the
T12600 455-460 NN denotes IRF-4
T12601 461-469 NN denotes promoter
T12602 469-470 , denotes ,
T12603 471-476 WDT denotes which
T12604 477-480 MD denotes can
T12605 481-488 VB denotes account
T12606 489-492 IN denotes for
T12607 493-496 DT denotes the
T12608 497-501 NN denotes lack
T12609 502-504 IN denotes of
T12610 505-510 NN denotes IRF-4
T12611 511-521 NN denotes expression
T12612 521-522 : denotes :
T12613 523-526 DT denotes The
T12614 527-535 VBN denotes detected
T12615 536-540 NN denotes base
T12616 541-545 NN denotes pair
T12617 546-553 NNS denotes changes
T12618 554-556 IN denotes at
T12619 557-565 NN denotes position
T12620 566-567 NN denotes −
T12621 567-571 CD denotes 1081
T12622 572-573 -LRB- denotes (
T12623 573-574 NNP denotes T
T12624 574-575 CD denotes →
T12625 575-576 NNP denotes C
T12626 577-589 NN denotes substitution
T12627 589-590 -RRB- denotes )
T12628 590-591 , denotes ,
T12629 592-594 IN denotes at
T12630 595-603 NN denotes position
T12631 604-605 NN denotes −
T12632 605-609 CD denotes 1068
T12633 610-611 -LRB- denotes (
T12634 611-612 DT denotes A
T12635 612-613 NN denotes →
T12636 613-614 NNP denotes C
T12637 615-627 NN denotes substitution
T12638 627-628 -RRB- denotes )
T12639 629-632 CC denotes and
T12640 633-635 IN denotes at
T12641 636-644 NN denotes position
T12642 645-646 NN denotes −
T12643 646-649 CD denotes 116
T12644 650-651 -LRB- denotes (
T12645 651-652 DT denotes A
T12646 652-653 NN denotes →
T12647 653-654 NNP denotes C
T12648 655-667 NN denotes substitution
T12649 667-668 -RRB- denotes )
T12650 669-672 VBP denotes are
T12651 673-681 JJ denotes unlikely
T12652 682-693 JJ denotes responsible
T12653 694-697 IN denotes for
T12654 698-704 JJ denotes absent
T12655 705-721 NN denotes IRF-4-expression
T12656 722-727 IN denotes since
T12657 728-731 DT denotes the
T12658 732-737 JJ denotes first
T12659 738-741 CD denotes two
T12660 742-751 NNS denotes mutations
T12661 752-756 VBD denotes were
T12662 757-762 VBN denotes found
T12663 763-767 DT denotes both
T12664 768-770 IN denotes in
T12665 771-785 JJ denotes IRF-4-positive
T12666 786-789 CC denotes and
T12667 790-791 : denotes -
T12668 791-799 JJ denotes negative
T12669 800-805 NNS denotes cells
T12670 806-813 IN denotes whereas
T12671 814-817 DT denotes the
T12672 818-824 JJ denotes latter
T12673 825-831 NN denotes change
T12674 832-835 VBD denotes was
T12675 836-839 RB denotes not
T12676 840-848 VBN denotes detected
T12677 849-861 RB denotes consistently
T12678 862-864 IN denotes in
T12679 865-868 DT denotes all
T12680 869-883 JJ denotes IRF-4-negative
T12681 884-886 CC denotes or
T12682 887-888 : denotes -
T12683 888-896 JJ denotes positive
T12684 897-902 NNS denotes cells
T12685 903-906 CC denotes and
T12686 907-910 MD denotes may
T12687 911-915 RB denotes thus
T12688 916-918 VB denotes be
T12689 919-920 DT denotes a
T12690 921-933 NN denotes polymorphism
T12691 933-934 . denotes .
T12692 935-938 DT denotes All
T12693 939-944 CD denotes three
T12694 945-958 NNS denotes substitutions
T12695 959-962 VBD denotes did
T12696 963-966 RB denotes not
T12697 967-973 VB denotes change
T12698 974-977 DT denotes any
T12699 978-983 JJ denotes known
T12700 984-992 JJ denotes putative
T12701 993-1006 NN denotes transcription
T12702 1007-1013 NN denotes factor
T12703 1014-1021 JJ denotes binding
T12704 1022-1027 NNS denotes sites
T12705 1028-1029 -LRB- denotes (
T12706 1029-1034 CD denotes 30,31
T12707 1034-1035 -RRB- denotes )
T12708 1036-1039 CC denotes and
T12709 1040-1044 RB denotes also
T12710 1045-1047 VBP denotes do
T12711 1048-1051 RB denotes not
T12712 1052-1058 VB denotes affect
T12713 1059-1062 DT denotes any
T12714 1063-1074 NN denotes restriction
T12715 1075-1080 NNS denotes sites
T12716 1081-1083 CC denotes or
T12717 1084-1090 JJR denotes primer
T12718 1091-1098 JJ denotes binding
T12719 1099-1104 NNS denotes sites
T12720 1105-1107 IN denotes of
T12721 1108-1111 DT denotes the
T12722 1112-1116 VBN denotes used
T12723 1117-1123 NNS denotes assays
T12724 1123-1124 . denotes .
T12725 1125-1132 RB denotes However
T12726 1132-1133 , denotes ,
T12727 1134-1143 JJ denotes permanent
T12728 1144-1151 JJ denotes genetic
T12729 1152-1162 NNS denotes variations
T12730 1163-1165 IN denotes in
T12731 1166-1169 DT denotes the
T12732 1170-1175 NN denotes IRF-4
T12733 1176-1182 VBG denotes coding
T12734 1183-1191 NN denotes sequence
T12735 1191-1192 , denotes ,
T12736 1193-1197 JJ denotes such
T12737 1198-1200 IN denotes as
T12738 1201-1210 NNS denotes deletions
T12739 1211-1213 CC denotes or
T12740 1214-1223 NNS denotes mutations
T12741 1224-1233 VBG denotes resulting
T12742 1234-1236 IN denotes in
T12743 1237-1248 NNS denotes stop-codons
T12744 1249-1253 VBP denotes have
T12745 1254-1257 RB denotes not
T12746 1258-1262 VBN denotes been
T12747 1263-1271 VBN denotes excluded
T12748 1272-1274 IN denotes by
T12749 1275-1283 NN denotes sequence
T12750 1284-1292 NN denotes analysis
T12751 1292-1293 . denotes .
T12752 1294-1299 IN denotes Since
T12753 1300-1305 NNP denotes IRF-4
T12754 1306-1316 NN denotes expression
T12755 1317-1319 IN denotes in
T12756 1320-1324 NN denotes cell
T12757 1325-1330 NNS denotes lines
T12758 1331-1334 CC denotes and
T12759 1335-1338 NNP denotes CML
T12760 1339-1342 MD denotes can
T12761 1343-1345 VB denotes be
T12762 1346-1353 VBN denotes induced
T12763 1354-1356 IN denotes by
T12764 1357-1370 NN denotes demethylation
T12765 1371-1374 CC denotes and
T12766 1375-1385 JJ denotes successful
T12767 1386-1391 JJ denotes IFN-α
T12768 1392-1399 NN denotes therapy
T12769 1400-1401 -LRB- denotes (
T12770 1401-1402 LS denotes 3
T12771 1402-1403 -RRB- denotes )
T12772 1403-1404 , denotes ,
T12773 1405-1417 RB denotes respectively
T12774 1417-1418 , denotes ,
T12775 1419-1422 DT denotes the
T12776 1423-1432 NN denotes existence
T12777 1433-1435 IN denotes of
T12778 1436-1440 JJ denotes such
T12779 1441-1448 JJ denotes genetic
T12780 1449-1460 NNS denotes aberrations
T12781 1461-1466 VBZ denotes seems
T12782 1467-1475 JJ denotes unlikely
T12783 1475-1476 . denotes .
T12784 1477-1479 PRP denotes We
T12785 1480-1484 RB denotes then
T12786 1485-1497 VBD denotes investigated
T12787 1498-1505 IN denotes whether
T12788 1506-1509 DT denotes the
T12789 1510-1520 RB denotes previously
T12790 1521-1530 VBN denotes described
T12791 1531-1546 NN denotes down-regulation
T12792 1547-1549 IN denotes of
T12793 1550-1555 NN denotes IRF-4
T12794 1556-1566 NN denotes expression
T12795 1567-1569 IN denotes in
T12796 1570-1575 JJ denotes human
T12797 1576-1583 JJ denotes myeloid
T12798 1584-1593 NNS denotes leukemias
T12799 1594-1597 VBD denotes was
T12800 1598-1601 JJ denotes due
T12801 1602-1604 TO denotes to
T12802 1605-1606 DT denotes a
T12803 1607-1619 JJ denotes differential
T12804 1620-1636 NN denotes hypermethylation
T12805 1637-1639 IN denotes of
T12806 1640-1643 DT denotes the
T12807 1644-1652 NN denotes promoter
T12808 1652-1653 , denotes ,
T12809 1654-1659 IN denotes since
T12810 1660-1663 DT denotes the
T12811 1664-1673 VBN denotes presented
T12812 1674-1687 NN denotes re-expression
T12813 1688-1691 JJ denotes due
T12814 1692-1694 TO denotes to
T12815 1695-1710 NNP denotes AzadC-treatment
T12816 1711-1716 MD denotes might
T12817 1717-1721 RB denotes also
T12818 1722-1724 VB denotes be
T12819 1725-1726 DT denotes a
T12820 1727-1733 NN denotes result
T12821 1734-1736 IN denotes of
T12822 1737-1747 NN denotes activation
T12823 1748-1750 IN denotes of
T12824 1751-1759 JJ denotes positive
T12825 1760-1775 JJ denotes transcriptional
T12826 1776-1786 NNS denotes regulators
T12827 1787-1789 IN denotes of
T12828 1790-1795 NN denotes IRF-4
T12829 1795-1796 . denotes .
T12830 1797-1808 NNP denotes Methylation
T12831 1809-1811 IN denotes of
T12832 1812-1815 NNP denotes CpG
T12833 1816-1821 NNS denotes sites
T12834 1822-1824 VBZ denotes is
T12835 1825-1826 DT denotes a
T12836 1827-1833 JJ denotes common
T12837 1834-1843 NN denotes mechanism
T12838 1844-1846 IN denotes of
T12839 1847-1856 VBG denotes silencing
T12840 1857-1862 NNS denotes genes
T12841 1863-1865 IN denotes in
T12842 1866-1874 NN denotes leukemia
T12843 1875-1878 CC denotes and
T12844 1879-1882 VBZ denotes has
T12845 1883-1887 RB denotes also
T12846 1888-1892 VBN denotes been
T12847 1893-1898 VBN denotes shown
T12848 1899-1902 IN denotes for
T12849 1903-1910 DT denotes another
T12850 1911-1914 NNP denotes IRF
T12851 1914-1915 , denotes ,
T12852 1916-1921 NNP denotes IRF-7
T12853 1922-1923 -LRB- denotes (
T12854 1923-1925 CD denotes 35
T12855 1925-1926 -RRB- denotes )
T12856 1927-1930 CC denotes and
T12857 1931-1934 IN denotes for
T12858 1935-1937 NNP denotes PU
T12859 1937-1939 CD denotes .1
T12860 1940-1941 -LRB- denotes (
T12861 1941-1943 CD denotes 36
T12862 1943-1944 -RRB- denotes )
T12863 1944-1945 , denotes ,
T12864 1946-1948 DT denotes an
T12865 1949-1960 VBG denotes interacting
T12866 1961-1968 NN denotes partner
T12867 1969-1971 IN denotes of
T12868 1972-1977 NN denotes IRF-4
T12869 1977-1978 . denotes .
T12870 1979-1981 TO denotes To
T12871 1982-1991 VB denotes elucidate
T12872 1992-1995 DT denotes the
T12873 1996-2005 NN denotes relevance
T12874 2006-2008 IN denotes of
T12875 2009-2013 DT denotes this
T12876 2014-2023 NN denotes mechanism
T12877 2024-2027 IN denotes for
T12878 2028-2031 DT denotes the
T12879 2032-2042 NN denotes regulation
T12880 2043-2045 IN denotes of
T12881 2046-2051 NN denotes IRF-4
T12882 2052-2062 NN denotes expression
T12883 2062-2063 , denotes ,
T12884 2064-2071 JJ denotes various
T12885 2072-2080 JJ denotes leukemic
T12886 2081-2086 NNS denotes cells
T12887 2087-2091 VBD denotes were
T12888 2092-2099 VBN denotes treated
T12889 2100-2104 IN denotes with
T12890 2105-2118 VBG denotes demethylating
T12891 2119-2125 NNS denotes agents
T12892 2126-2129 CC denotes and
T12893 2130-2139 NNS denotes promoters
T12894 2140-2144 VBD denotes were
T12895 2145-2154 VBN denotes sequenced
T12896 2155-2160 IN denotes after
T12897 2161-2170 JJ denotes bisulfite
T12898 2171-2180 NN denotes treatment
T12899 2180-2181 . denotes .
T12900 2182-2184 PRP denotes We
T12901 2185-2190 VBD denotes found
T12902 2191-2195 IN denotes that
T12903 2196-2201 JJ denotes IRF-4
T12904 2202-2212 NN denotes expression
T12905 2213-2218 MD denotes could
T12906 2219-2225 RB denotes indeed
T12907 2226-2228 VB denotes be
T12908 2229-2238 VBN denotes connected
T12909 2239-2241 TO denotes to
T12910 2242-2245 DT denotes the
T12911 2246-2257 NN denotes methylation
T12912 2258-2264 NN denotes status
T12913 2265-2267 IN denotes of
T12914 2268-2276 JJ denotes distinct
T12915 2277-2280 NNP denotes CpG
T12916 2281-2287 NNS denotes motifs
T12917 2288-2290 IN denotes in
T12918 2291-2294 DT denotes the
T12919 2295-2300 NN denotes IRF-4
T12920 2301-2309 NN denotes promoter
T12921 2309-2310 . denotes .
T12922 2311-2313 IN denotes In
T12923 2314-2320 NNP denotes Figure
T12924 2321-2323 NNP denotes 4A
T12925 2323-2324 , denotes ,
T12926 2325-2330 DT denotes those
T12927 2331-2334 NNP denotes CpG
T12928 2335-2340 NNS denotes sites
T12929 2341-2344 VBP denotes are
T12930 2345-2350 VBN denotes shown
T12931 2351-2352 -LRB- denotes (
T12932 2352-2358 JJ denotes bottom
T12933 2359-2363 NN denotes line
T12934 2363-2364 -RRB- denotes )
T12935 2364-2365 , denotes ,
T12936 2366-2371 WP$ denotes whose
T12937 2372-2388 NN denotes hypermethylation
T12938 2389-2392 MD denotes may
T12939 2393-2400 VB denotes account
T12940 2401-2404 IN denotes for
T12941 2405-2408 DT denotes the
T12942 2409-2416 NN denotes absence
T12943 2417-2419 IN denotes of
T12944 2420-2425 NN denotes IRF-4
T12945 2426-2436 NN denotes expression
T12946 2437-2439 IN denotes in
T12947 2440-2443 DT denotes the
T12948 2444-2454 JJ denotes respective
T12949 2455-2460 NNS denotes cells
T12950 2460-2461 . denotes .
T12951 2462-2465 CD denotes One
T12952 2466-2468 IN denotes of
T12953 2469-2473 PRP denotes them
T12954 2474-2475 -LRB- denotes (
T12955 2475-2476 # denotes #
T12956 2476-2478 CD denotes 54
T12957 2478-2479 -RRB- denotes )
T12958 2480-2482 VBZ denotes is
T12959 2483-2491 JJ denotes adjacent
T12960 2492-2494 TO denotes to
T12961 2495-2497 DT denotes an
T12962 2498-2508 VBN denotes identified
T12963 2509-2519 JJ denotes regulatory
T12964 2520-2527 NN denotes element
T12965 2528-2529 -LRB- denotes (
T12966 2529-2538 JJ denotes NFκB-site
T12967 2538-2539 -RRB- denotes )
T12968 2539-2540 , denotes ,
T12969 2541-2551 VBG denotes indicating
T12970 2552-2553 DT denotes a
T12971 2554-2562 JJ denotes possible
T12972 2563-2574 NN denotes involvement
T12973 2575-2577 IN denotes of
T12974 2578-2582 DT denotes this
T12975 2583-2587 NN denotes site
T12976 2587-2588 . denotes .
T12977 2589-2591 IN denotes At
T12978 2592-2595 CD denotes two
T12979 2596-2603 JJ denotes further
T12980 2604-2607 NNP denotes CpG
T12981 2608-2613 NNS denotes sites
T12982 2614-2615 -LRB- denotes (
T12983 2615-2616 # denotes #
T12984 2616-2618 CD denotes 48
T12985 2618-2619 , denotes ,
T12986 2620-2622 CD denotes 45
T12987 2622-2623 -RRB- denotes )
T12988 2624-2627 DT denotes the
T12989 2628-2639 NN denotes methylation
T12990 2640-2646 NN denotes status
T12991 2647-2649 IN denotes in
T12992 2650-2664 JJ denotes IRF-4-positive
T12993 2665-2668 VBD denotes was
T12994 2669-2674 JJR denotes lower
T12995 2675-2679 IN denotes than
T12996 2680-2684 DT denotes that
T12997 2685-2687 IN denotes of
T12998 2688-2702 JJ denotes IRF-4-negative
T12999 2703-2708 NNS denotes cells
T13000 2708-2709 . denotes .
T13001 2710-2715 DT denotes These
T13002 2716-2719 NNP denotes CpG
T13003 2720-2725 NNS denotes sites
T13004 2726-2729 VBP denotes are
T13005 2730-2737 VBN denotes located
T13006 2738-2740 IN denotes in
T13007 2741-2743 DT denotes an
T13008 2744-2748 NNP denotes NFκB
T13009 2749-2752 CC denotes and
T13010 2753-2755 DT denotes an
T13011 2756-2759 CD denotes SP1
T13012 2760-2767 NN denotes element
T13013 2768-2769 -LRB- denotes (
T13014 2769-2771 CD denotes 31
T13015 2771-2772 -RRB- denotes )
T13016 2773-2776 CC denotes and
T13017 2777-2781 RB denotes thus
T13018 2782-2785 MD denotes may
T13019 2786-2790 RB denotes also
T13020 2791-2795 VB denotes play
T13021 2796-2797 DT denotes a
T13022 2798-2802 NN denotes role
T13023 2803-2805 IN denotes in
T13024 2806-2816 NN denotes regulation
T13025 2817-2819 IN denotes of
T13026 2820-2825 NN denotes IRF-4
T13027 2826-2836 NN denotes expression
T13028 2836-2837 . denotes .
T13029 2838-2840 PRP denotes It
T13030 2841-2844 VBZ denotes has
T13031 2845-2849 VBN denotes been
T13032 2850-2855 VBN denotes shown
T13033 2856-2860 IN denotes that
T13034 2861-2865 NNP denotes NFκB
T13035 2866-2874 NNS denotes elements
T13036 2875-2879 VBP denotes play
T13037 2880-2882 DT denotes an
T13038 2883-2892 JJ denotes important
T13039 2893-2897 NN denotes role
T13040 2898-2900 IN denotes in
T13041 2901-2906 NN denotes IRF-4
T13042 2907-2916 NN denotes induction
T13043 2917-2919 IN denotes as
T13044 2920-2925 JJ denotes IRF-4
T13045 2926-2936 NN denotes expression
T13046 2937-2944 VBZ denotes depends
T13047 2945-2947 IN denotes on
T13048 2948-2955 JJ denotes binding
T13049 2956-2958 IN denotes of
T13050 2959-2962 DT denotes the
T13051 2963-2977 NN denotes transactivator
T13052 2978-2983 NN denotes c-Rel
T13053 2984-2986 TO denotes to
T13054 2987-2992 DT denotes these
T13055 2993-3001 NNS denotes elements
T13056 3002-3004 IN denotes in
T13057 3005-3008 DT denotes the
T13058 3009-3014 NN denotes IRF-4
T13059 3015-3023 NN denotes promoter
T13060 3024-3025 -LRB- denotes (
T13061 3025-3030 CD denotes 31,37
T13062 3030-3031 -RRB- denotes )
T13063 3031-3032 . denotes .
T13064 3033-3044 RB denotes Furthermore
T13065 3044-3045 , denotes ,
T13066 3046-3057 NN denotes methylation
T13067 3058-3060 IN denotes of
T13068 3061-3064 DT denotes the
T13069 3065-3072 JJ denotes central
T13070 3073-3076 NNP denotes CpG
T13071 3077-3079 IN denotes in
T13072 3080-3083 DT denotes the
T13073 3084-3088 NNP denotes NFκB
T13074 3089-3096 NN denotes element
T13075 3097-3105 VBZ denotes inhibits
T13076 3106-3113 JJ denotes binding
T13077 3114-3116 IN denotes of
T13078 3117-3120 DT denotes the
T13079 3121-3125 NNP denotes NFκB
T13080 3126-3133 NN denotes protein
T13081 3134-3143 NNS denotes complexes
T13082 3144-3145 -LRB- denotes (
T13083 3145-3147 CD denotes 38
T13084 3147-3148 -RRB- denotes )
T13085 3148-3149 , denotes ,
T13086 3150-3159 VBG denotes promoting
T13087 3160-3163 DT denotes the
T13088 3164-3176 NN denotes significance
T13089 3177-3179 IN denotes of
T13090 3180-3183 DT denotes the
T13091 3184-3192 JJ denotes observed
T13092 3193-3204 NN denotes methylation
T13093 3205-3216 NNS denotes differences
T13094 3217-3219 IN denotes in
T13095 3220-3234 JJ denotes IRF-4-positive
T13096 3235-3238 CC denotes and
T13097 3239-3240 : denotes -
T13098 3240-3248 JJ denotes negative
T13099 3249-3254 NNS denotes cells
T13100 3254-3255 . denotes .
T13101 3256-3259 NNP denotes Via
T13102 3260-3262 IN denotes in
T13103 3263-3268 NN denotes vitro
T13104 3269-3280 NN denotes methylation
T13105 3281-3284 CC denotes and
T13106 3285-3293 NN denotes reporter
T13107 3294-3298 NN denotes gene
T13108 3299-3305 IN denotes assays
T13109 3306-3308 PRP denotes we
T13110 3309-3314 MD denotes could
T13111 3315-3322 RB denotes clearly
T13112 3323-3330 VB denotes appoint
T13113 3331-3334 DT denotes the
T13114 3335-3344 NN denotes silencing
T13115 3345-3347 IN denotes of
T13116 3348-3351 DT denotes the
T13117 3352-3357 NN denotes IRF-4
T13118 3358-3366 NN denotes promoter
T13119 3367-3369 TO denotes to
T13120 3370-3371 DT denotes a
T13121 3372-3383 NN denotes methylation
T13122 3384-3390 NN denotes effect
T13123 3390-3391 , denotes ,
T13124 3392-3397 WDT denotes which
T13125 3398-3401 MD denotes may
T13126 3402-3406 RB denotes thus
T13127 3407-3409 VB denotes be
T13128 3410-3413 DT denotes the
T13129 3414-3423 NN denotes mechanism
T13130 3424-3426 IN denotes of
T13131 3427-3432 NN denotes IRF-4
T13132 3433-3445 NN denotes deregulation
T13133 3446-3448 IN denotes in
T13134 3449-3453 NN denotes vivo
T13135 3453-3454 . denotes .
T13136 3455-3458 CD denotes One
T13137 3459-3467 JJ denotes possible
T13138 3468-3473 NN denotes cause
T13139 3474-3477 IN denotes for
T13140 3478-3481 DT denotes the
T13141 3482-3490 JJ denotes aberrant
T13142 3491-3502 NN denotes methylation
T13143 3503-3505 IN denotes in
T13144 3506-3519 NN denotes tumorigenesis
T13145 3520-3522 VBZ denotes is
T13146 3523-3525 DT denotes an
T13147 3526-3535 JJ denotes increased
T13148 3536-3541 NN denotes level
T13149 3542-3544 IN denotes of
T13150 3545-3550 NNS denotes DNMTs
T13151 3551-3557 IN denotes during
T13152 3558-3561 DT denotes the
T13153 3562-3574 JJ denotes pathogenetic
T13154 3575-3582 NN denotes process
T13155 3582-3583 . denotes .
T13156 3584-3586 IN denotes In
T13157 3587-3592 NN denotes colon
T13158 3592-3593 , denotes ,
T13159 3594-3598 NN denotes lung
T13160 3599-3602 CC denotes and
T13161 3603-3614 JJ denotes hematologic
T13162 3615-3627 NNS denotes malignancies
T13163 3627-3628 , denotes ,
T13164 3629-3643 NN denotes overexpression
T13165 3644-3646 IN denotes of
T13166 3647-3652 NNP denotes DNMT1
T13167 3652-3653 , denotes ,
T13168 3654-3655 DT denotes a
T13169 3656-3667 NN denotes maintenance
T13170 3668-3672 NNP denotes DNMT
T13171 3672-3673 , denotes ,
T13172 3674-3677 VBZ denotes has
T13173 3678-3682 VBN denotes been
T13174 3683-3691 VBN denotes detected
T13175 3692-3693 -LRB- denotes (
T13176 3693-3695 CD denotes 39
T13177 3696-3698 CD denotes 41
T13178 3698-3699 -RRB- denotes )
T13179 3699-3700 . denotes .
T13180 3701-3712 RB denotes Furthermore
T13181 3712-3713 , denotes ,
T13182 3714-3716 PRP denotes it
T13183 3717-3720 VBZ denotes has
T13184 3721-3725 VBN denotes been
T13185 3726-3731 VBN denotes shown
T13186 3732-3736 IN denotes that
T13187 3737-3740 NNP denotes CML
T13188 3741-3746 NNS denotes cells
T13189 3747-3749 IN denotes in
T13190 3750-3753 DT denotes the
T13191 3754-3759 JJ denotes acute
T13192 3760-3765 NN denotes phase
T13193 3766-3775 VBD denotes exhibited
T13194 3776-3784 JJ denotes elevated
T13195 3785-3791 NNS denotes levels
T13196 3792-3794 IN denotes of
T13197 3795-3798 DT denotes the
T13198 3799-3804 CD denotes three
T13199 3805-3810 VBN denotes known
T13200 3811-3816 NNP denotes DNMTs
T13201 3816-3817 , denotes ,
T13202 3818-3823 IN denotes while
T13203 3824-3827 NNP denotes CML
T13204 3828-3833 NNS denotes cells
T13205 3834-3836 IN denotes in
T13206 3837-3844 JJ denotes chronic
T13207 3845-3850 NN denotes phase
T13208 3851-3860 VBD denotes expressed
T13209 3861-3867 JJ denotes normal
T13210 3868-3874 NNS denotes levels
T13211 3875-3877 IN denotes of
T13212 3878-3883 NNP denotes DNMTs
T13213 3884-3886 IN denotes if
T13214 3887-3895 VBN denotes compared
T13215 3896-3900 IN denotes with
T13216 3901-3907 JJ denotes normal
T13217 3908-3912 NN denotes bone
T13218 3913-3919 NN denotes marrow
T13219 3920-3925 NNS denotes cells
T13220 3926-3927 -LRB- denotes (
T13221 3927-3929 CD denotes 25
T13222 3929-3930 -RRB- denotes )
T13223 3930-3931 . denotes .
T13224 3932-3945 RB denotes Interestingly
T13225 3945-3946 , denotes ,
T13226 3947-3948 DT denotes a
T13227 3949-3957 JJ denotes positive
T13228 3958-3969 NN denotes correlation
T13229 3970-3977 IN denotes between
T13230 3978-3983 CD denotes DNMT1
T13231 3984-3994 NN denotes expression
T13232 3995-4001 NNS denotes levels
T13233 4002-4005 CC denotes and
T13234 4006-4022 NN denotes hypermethylation
T13235 4023-4025 IN denotes of
T13236 4026-4034 NNP denotes p15INK4b
T13237 4035-4038 VBZ denotes has
T13238 4039-4043 VBN denotes been
T13239 4044-4052 VBN denotes detected
T13240 4053-4055 IN denotes in
T13241 4056-4059 NNP denotes AML
T13242 4060-4061 -LRB- denotes (
T13243 4061-4063 CD denotes 25
T13244 4063-4064 -RRB- denotes )
T13245 4064-4065 . denotes .
T13246 4066-4068 IN denotes In
T13247 4069-4073 DT denotes this
T13248 4074-4078 NN denotes work
T13249 4078-4079 , denotes ,
T13250 4080-4082 PRP denotes we
T13251 4083-4086 VBD denotes did
T13252 4087-4090 RB denotes not
T13253 4091-4097 VB denotes detect
T13254 4098-4109 JJ denotes significant
T13255 4110-4114 NNP denotes mRNA
T13256 4115-4125 NN denotes expression
T13257 4126-4137 NNS denotes differences
T13258 4138-4140 IN denotes of
T13259 4141-4149 VBN denotes selected
T13260 4150-4154 NNP denotes DNMT
T13261 4155-4157 CC denotes or
T13262 4158-4161 NNP denotes MBP
T13263 4161-4162 , denotes ,
T13264 4163-4169 VBG denotes making
T13265 4170-4172 PRP denotes it
T13266 4173-4175 DT denotes an
T13267 4176-4184 JJ denotes unlikely
T13268 4185-4190 NN denotes cause
T13269 4191-4194 IN denotes for
T13270 4195-4198 DT denotes the
T13271 4199-4207 JJ denotes observed
T13272 4208-4219 NN denotes methylation
T13273 4220-4223 CC denotes and
T13274 4224-4228 RB denotes thus
T13275 4229-4234 JJ denotes IRF-4
T13276 4235-4245 NN denotes expression
T13277 4246-4257 NNS denotes differences
T13278 4258-4260 IN denotes in
T13279 4261-4269 NN denotes leukemia
T13280 4270-4275 NNS denotes cells
T13281 4275-4276 . denotes .
T13282 4277-4280 DT denotes The
T13283 4281-4288 NN denotes finding
T13284 4289-4293 WDT denotes that
T13285 4294-4299 NNP denotes IRF-4
T13286 4300-4310 NN denotes expression
T13287 4311-4313 VBZ denotes is
T13288 4314-4322 VBN denotes silenced
T13289 4323-4325 IN denotes by
T13290 4326-4334 NN denotes promoter
T13291 4335-4351 NN denotes hypermethylation
T13292 4352-4357 MD denotes might
T13293 4358-4367 VB denotes represent
T13294 4368-4369 DT denotes a
T13295 4370-4379 NN denotes mechanism
T13296 4380-4384 WDT denotes that
T13297 4385-4393 VBZ denotes accounts
T13298 4394-4397 IN denotes for
T13299 4398-4401 DT denotes the
T13300 4402-4412 RB denotes previously
T13301 4413-4421 JJ denotes observed
T13302 4422-4426 NN denotes loss
T13303 4427-4429 IN denotes of
T13304 4430-4435 NN denotes IRF-4
T13305 4436-4446 NN denotes expression
T13306 4447-4449 IN denotes in
T13307 4450-4453 NNP denotes CML
T13308 4453-4454 . denotes .
T13309 4455-4461 RB denotes Indeed
T13310 4461-4462 , denotes ,
T13311 4463-4470 JJ denotes several
T13312 4471-4479 JJ denotes clinical
T13313 4480-4486 NNS denotes trials
T13314 4487-4491 IN denotes with
T13315 4492-4500 NN denotes leukemia
T13316 4501-4509 NNS denotes patients
T13317 4510-4513 CC denotes and
T13318 4514-4522 NNS denotes patients
T13319 4523-4527 IN denotes with
T13320 4528-4543 JJ denotes myelodysplastic
T13321 4544-4553 NNS denotes syndromes
T13322 4554-4566 VBD denotes demonstrated
T13323 4567-4570 DT denotes the
T13324 4571-4580 JJ denotes potential
T13325 4581-4589 JJ denotes clinical
T13326 4590-4597 NN denotes benefit
T13327 4598-4600 IN denotes of
T13328 4601-4602 DT denotes a
T13329 4603-4612 NN denotes treatment
T13330 4613-4617 IN denotes with
T13331 4618-4631 VBG denotes demethylating
T13332 4632-4638 NNS denotes agents
T13333 4639-4640 -LRB- denotes (
T13334 4640-4642 CD denotes 42
T13335 4643-4645 CD denotes 45
T13336 4645-4646 -RRB- denotes )
T13337 4646-4647 . denotes .
T13338 4648-4651 DT denotes The
T13339 4652-4662 NN denotes expression
T13340 4663-4665 IN denotes of
T13341 4666-4673 DT denotes another
T13342 4674-4677 NNP denotes IRF
T13343 4677-4678 , denotes ,
T13344 4679-4682 NNP denotes IFN
T13345 4683-4692 NN denotes consensus
T13346 4693-4701 NN denotes sequence
T13347 4702-4709 JJ denotes binding
T13348 4710-4717 NN denotes protein
T13349 4718-4719 -LRB- denotes (
T13350 4719-4728 NNP denotes ICSBP/IRF
T13351 4728-4730 CD denotes -8
T13352 4730-4731 -RRB- denotes )
T13353 4731-4732 , denotes ,
T13354 4733-4735 VBZ denotes is
T13355 4736-4744 VBN denotes impaired
T13356 4745-4747 IN denotes in
T13357 4748-4755 JJ denotes myeloid
T13358 4756-4765 NNS denotes leukemias
T13359 4766-4776 RB denotes especially
T13360 4777-4780 NNP denotes CML
T13361 4781-4782 -LRB- denotes (
T13362 4782-4790 CD denotes 27,46,47
T13363 4790-4791 -RRB- denotes )
T13364 4791-4792 . denotes .
T13365 4793-4796 CC denotes But
T13366 4797-4799 IN denotes in
T13367 4800-4808 NN denotes contrast
T13368 4809-4811 TO denotes to
T13369 4812-4817 NNP denotes IRF-4
T13370 4817-4818 , denotes ,
T13371 4819-4822 DT denotes the
T13372 4823-4827 NN denotes loss
T13373 4828-4830 IN denotes of
T13374 4831-4835 DT denotes this
T13375 4836-4839 NNP denotes IRF
T13376 4840-4845 MD denotes could
T13377 4846-4849 RB denotes not
T13378 4850-4852 VB denotes be
T13379 4853-4861 VBN denotes reverted
T13380 4862-4864 IN denotes in
T13381 4865-4879 JJ denotes ICSBP-negative
T13382 4880-4884 NN denotes cell
T13383 4885-4890 NNS denotes lines
T13384 4891-4892 -LRB- denotes (
T13385 4892-4896 NN denotes EM-2
T13386 4896-4897 , denotes ,
T13387 4898-4904 NNP denotes CML-T1
T13388 4904-4905 , denotes ,
T13389 4906-4911 NNP denotes K-562
T13390 4912-4915 CC denotes and
T13391 4916-4923 NNP denotes LAMA-84
T13392 4923-4924 -RRB- denotes )
T13393 4925-4927 IN denotes by
T13394 4928-4937 NN denotes treatment
T13395 4938-4942 IN denotes with
T13396 4943-4948 NNP denotes AzadC
T13397 4949-4950 -LRB- denotes (
T13398 4950-4956 NNP denotes Figure
T13399 4957-4958 CD denotes 6
T13400 4958-4959 -RRB- denotes )
T13401 4960-4963 CC denotes and
T13402 4964-4969 NNP denotes AzadC
T13403 4970-4973 VBZ denotes has
T13404 4974-4976 DT denotes no
T13405 4977-4983 NN denotes effect
T13406 4984-4986 IN denotes on
T13407 4987-4992 NNP denotes ICSBP
T13408 4993-4999 NNS denotes levels
T13409 5000-5002 IN denotes in
T13410 5003-5017 JJ denotes ICSBP-positive
T13411 5018-5023 NNP denotes U-937
T13412 5024-5029 NNS denotes cells
T13413 5030-5031 -LRB- denotes (
T13414 5031-5037 NN denotes Figure
T13415 5038-5039 CD denotes 6
T13416 5039-5040 -RRB- denotes )
T13417 5040-5041 . denotes .
T13418 5042-5047 DT denotes These
T13419 5048-5052 NNS denotes data
T13420 5053-5060 VBP denotes suggest
T13421 5061-5062 DT denotes a
T13422 5063-5071 JJ denotes distinct
T13423 5072-5082 JJ denotes regulatory
T13424 5083-5092 NN denotes mechanism
T13425 5093-5096 IN denotes for
T13426 5097-5102 DT denotes these
T13427 5103-5106 CD denotes two
T13428 5107-5111 NNS denotes IRFs
T13429 5111-5112 . denotes .
T13430 5113-5118 NN denotes IRF-4
T13431 5118-5119 , denotes ,
T13432 5120-5127 JJ denotes similar
T13433 5128-5130 TO denotes to
T13434 5131-5135 JJ denotes many
T13435 5136-5141 JJ denotes other
T13436 5142-5151 JJ denotes classical
T13437 5152-5157 NN denotes tumor
T13438 5158-5168 NN denotes suppressor
T13439 5169-5174 NNS denotes genes
T13440 5175-5183 NNP denotes p15INK4b
T13441 5183-5184 , denotes ,
T13442 5185-5193 NNP denotes p16INK4a
T13443 5194-5196 CC denotes or
T13444 5197-5200 NN denotes p53
T13445 5200-5201 , denotes ,
T13446 5202-5205 MD denotes may
T13447 5206-5210 RB denotes thus
T13448 5211-5213 VB denotes be
T13449 5214-5215 DT denotes a
T13450 5216-5223 NN denotes subject
T13451 5224-5226 IN denotes of
T13452 5227-5238 NNS denotes alterations
T13453 5239-5241 IN denotes in
T13454 5242-5245 DT denotes the
T13455 5246-5254 NN denotes promoter
T13456 5255-5266 NN denotes methylation
T13457 5267-5273 NN denotes status
T13458 5274-5281 VBG denotes leading
T13459 5282-5284 TO denotes to
T13460 5285-5295 NN denotes expression
T13461 5296-5303 NNS denotes changes
T13462 5303-5304 , denotes ,
T13463 5305-5310 WDT denotes which
T13464 5311-5316 MD denotes might
T13465 5317-5327 VB denotes contribute
T13466 5328-5330 TO denotes to
T13467 5331-5334 DT denotes the
T13468 5335-5345 NN denotes initiation
T13469 5346-5352 CC denotes and/or
T13470 5353-5364 NN denotes progression
T13471 5365-5367 IN denotes of
T13472 5368-5374 NN denotes cancer
T13473 5374-5375 . denotes .
T13474 5376-5381 RB denotes Still
T13475 5381-5382 , denotes ,
T13476 5383-5386 DT denotes the
T13477 5387-5394 JJ denotes obvious
T13478 5395-5405 JJ denotes functional
T13479 5406-5415 NN denotes diversity
T13480 5416-5418 IN denotes of
T13481 5419-5424 NN denotes IRF-4
T13482 5425-5432 VBZ denotes remains
T13483 5433-5443 JJ denotes remarkable
T13484 5444-5447 CC denotes and
T13485 5448-5451 MD denotes can
T13486 5451-5454 RB denotes not
T13487 5455-5457 VB denotes be
T13488 5458-5463 RB denotes fully
T13489 5464-5473 VBN denotes explained
T13490 5474-5476 IN denotes by
T13491 5477-5480 DT denotes the
T13492 5481-5486 NN denotes IRF-4
T13493 5487-5495 NN denotes promoter
T13494 5496-5507 NN denotes methylation
T13495 5508-5514 NN denotes status
T13496 5514-5515 . denotes .
T13497 5516-5519 IN denotes For
T13498 5520-5527 NN denotes example
T13499 5527-5528 , denotes ,
T13500 5529-5534 NN denotes IRF-4
T13501 5535-5537 VBZ denotes is
T13502 5538-5547 RB denotes primarily
T13503 5548-5553 VBN denotes known
T13504 5554-5557 IN denotes for
T13505 5558-5561 PRP$ denotes its
T13506 5562-5571 JJ denotes oncogenic
T13507 5572-5580 NNS denotes features
T13508 5580-5581 . denotes .
T13509 5582-5584 IN denotes In
T13510 5585-5593 JJ denotes multiple
T13511 5594-5601 NN denotes myeloma
T13512 5602-5603 -LRB- denotes (
T13513 5603-5605 NNP denotes MM
T13514 5605-5606 -RRB- denotes )
T13515 5607-5608 DT denotes a
T13516 5609-5622 NN denotes translocation
T13517 5623-5625 IN denotes on
T13518 5626-5636 NN denotes chromosome
T13519 5637-5640 CD denotes 14q
T13520 5641-5644 VBD denotes was
T13521 5645-5653 VBN denotes reported
T13522 5654-5656 TO denotes to
T13523 5657-5661 VB denotes lead
T13524 5662-5664 TO denotes to
T13525 5665-5666 DT denotes a
T13526 5667-5673 NN denotes fusion
T13527 5674-5678 NN denotes gene
T13528 5679-5681 IN denotes of
T13529 5682-5696 NN denotes immunoglobulin
T13530 5697-5708 NN denotes heavy-chain
T13531 5709-5710 -LRB- denotes (
T13532 5710-5713 NNP denotes IgH
T13533 5713-5714 -RRB- denotes )
T13534 5715-5718 CC denotes and
T13535 5719-5724 JJ denotes IRF-4
T13536 5725-5734 VBG denotes resulting
T13537 5735-5737 IN denotes in
T13538 5738-5739 DT denotes a
T13539 5740-5750 JJ denotes subsequent
T13540 5751-5765 NN denotes overexpression
T13541 5766-5768 IN denotes of
T13542 5769-5774 NNP denotes IRF-4
T13543 5775-5776 -LRB- denotes (
T13544 5776-5781 CD denotes 48,49
T13545 5781-5782 -RRB- denotes )
T13546 5782-5783 . denotes .
T13547 5784-5786 IN denotes In
T13548 5787-5795 NN denotes addition
T13549 5795-5796 , denotes ,
T13550 5797-5805 JJ denotes abundant
T13551 5806-5811 NN denotes IRF-4
T13552 5812-5822 NN denotes expression
T13553 5823-5826 VBD denotes was
T13554 5827-5832 VBN denotes found
T13555 5833-5835 TO denotes to
T13556 5836-5838 VB denotes be
T13557 5839-5840 DT denotes a
T13558 5841-5847 NN denotes marker
T13559 5848-5851 IN denotes for
T13560 5852-5859 JJ denotes various
T13561 5860-5867 NNS denotes subsets
T13562 5868-5870 IN denotes of
T13563 5871-5880 NNS denotes lymphomas
T13564 5880-5881 , denotes ,
T13565 5882-5886 JJ denotes such
T13566 5887-5889 IN denotes as
T13567 5890-5897 NN denotes diffuse
T13568 5898-5903 JJ denotes large
T13569 5904-5910 NNP denotes B-cell
T13570 5911-5920 NNS denotes lymphomas
T13571 5920-5921 , denotes ,
T13572 5922-5929 JJ denotes primary
T13573 5930-5938 NN denotes effusion
T13574 5939-5947 NN denotes lymphoma
T13575 5947-5948 , denotes ,
T13576 5949-5952 CC denotes and
T13577 5953-5961 JJ denotes marginal
T13578 5962-5966 NN denotes zone
T13579 5967-5975 NN denotes lymphoma
T13580 5975-5976 , denotes ,
T13581 5977-5980 CC denotes and
T13582 5981-5986 NN denotes adult
T13583 5987-5993 NN denotes T-cell
T13584 5994-6002 NN denotes leukemia
T13585 6003-6004 -LRB- denotes (
T13586 6004-6012 CD denotes 11,31,50
T13587 6013-6015 CD denotes 52
T13588 6015-6016 -RRB- denotes )
T13589 6016-6017 . denotes .
T13590 6018-6022 DT denotes This
T13591 6023-6028 VBZ denotes draws
T13592 6029-6030 DT denotes a
T13593 6031-6035 RBR denotes more
T13594 6036-6043 JJ denotes complex
T13595 6044-6051 NN denotes picture
T13596 6052-6054 IN denotes of
T13597 6055-6058 DT denotes the
T13598 6059-6063 NN denotes role
T13599 6064-6066 IN denotes of
T13600 6067-6072 NN denotes IRF-4
T13601 6072-6073 . denotes .
T13602 6074-6089 NN denotes Down-regulation
T13603 6090-6092 IN denotes of
T13604 6093-6098 NN denotes IRF-4
T13605 6099-6102 MD denotes may
T13606 6103-6110 VB denotes promote
T13607 6111-6125 NN denotes leukemogenesis
T13608 6126-6128 IN denotes in
T13609 6129-6136 JJ denotes myeloid
T13610 6137-6141 NN denotes cell
T13611 6142-6149 NN denotes context
T13612 6150-6151 -LRB- denotes (
T13613 6151-6152 LS denotes 3
T13614 6152-6153 -RRB- denotes )
T13615 6153-6154 , denotes ,
T13616 6155-6160 WDT denotes which
T13617 6161-6164 VBD denotes was
T13618 6165-6173 RB denotes recently
T13619 6174-6183 VBN denotes confirmed
T13620 6184-6186 IN denotes in
T13621 6187-6192 NNP denotes IRF-4
T13622 6192-6193 FW denotes −
T13623 6193-6194 FW denotes /
T13624 6194-6195 FW denotes −
T13625 6196-6201 NNP denotes ICSBP
T13626 6201-6202 FW denotes −
T13627 6202-6203 FW denotes /
T13628 6203-6204 FW denotes −
T13629 6205-6211 JJ denotes double
T13630 6212-6221 NN denotes knock-out
T13631 6222-6226 NNS denotes mice
T13632 6227-6228 -LRB- denotes (
T13633 6228-6230 CD denotes 53
T13634 6230-6231 -RRB- denotes )
T13635 6231-6232 , denotes ,
T13636 6233-6238 IN denotes while
T13637 6239-6244 NNP denotes IRF-4
T13638 6245-6258 NN denotes up-regulation
T13639 6259-6262 MD denotes may
T13640 6263-6269 VB denotes induce
T13641 6270-6271 DT denotes a
T13642 6272-6278 NN denotes growth
T13643 6279-6288 NN denotes advantage
T13644 6289-6291 IN denotes in
T13645 6292-6301 NNS denotes lymphomas
T13646 6302-6304 CC denotes or
T13647 6305-6307 NNP denotes MM
T13648 6308-6309 -LRB- denotes (
T13649 6309-6311 CD denotes 48
T13650 6311-6312 -RRB- denotes )
T13651 6312-6313 . denotes .
T13652 6314-6319 VBN denotes Taken
T13653 6320-6328 RB denotes together
T13654 6328-6329 , denotes ,
T13655 6330-6333 PRP$ denotes our
T13656 6334-6338 NNS denotes data
T13657 6339-6346 VBP denotes suggest
T13658 6347-6351 IN denotes that
T13659 6352-6357 JJ denotes IRF-4
T13660 6358-6366 NN denotes promoter
T13661 6367-6378 NN denotes methylation
T13662 6379-6388 VBZ denotes regulates
T13663 6389-6394 JJ denotes IRF-4
T13664 6395-6405 NN denotes expression
T13665 6405-6406 , denotes ,
T13666 6407-6410 CC denotes and
T13667 6411-6415 IN denotes that
T13668 6416-6424 JJ denotes aberrant
T13669 6425-6435 NN denotes expression
T13670 6436-6438 IN denotes of
T13671 6439-6444 NN denotes IRF-4
T13672 6445-6447 IN denotes in
T13673 6448-6455 JJ denotes certain
T13674 6456-6461 NNS denotes types
T13675 6462-6464 IN denotes of
T13676 6465-6473 NN denotes leukemia
T13677 6474-6477 MD denotes may
T13678 6478-6480 VB denotes be
T13679 6481-6482 DT denotes a
T13680 6483-6494 NN denotes consequence
T13681 6495-6497 IN denotes of
T13682 6498-6503 NN denotes IRF-4
T13683 6504-6512 NN denotes promoter
T13684 6513-6529 NN denotes hypermethylation
T13685 6529-6530 . denotes .
R10353 T12531 T12533 amod Many,lesions
R10354 T12532 T12533 amod genetic,lesions
R10355 T12533 T12535 nsubjpass lesions,known
R10356 T12534 T12535 auxpass are,known
R10357 T12535 T12535 ROOT known,known
R10358 T12536 T12537 aux to,influence
R10359 T12537 T12535 xcomp influence,known
R10360 T12538 T12539 compound gene,expression
R10361 T12539 T12537 dobj expression,influence
R10362 T12540 T12539 prep of,expression
R10363 T12541 T12543 compound tumor,genes
R10364 T12542 T12543 compound suppressor,genes
R10365 T12543 T12540 pobj genes,of
R10366 T12544 T12535 punct .,known
R10367 T12545 T12551 mark Whereas,have
R10368 T12546 T12551 nsubj mutations,have
R10369 T12547 T12546 cc and,mutations
R10370 T12548 T12546 conj deletions,mutations
R10371 T12549 T12548 cc or,deletions
R10372 T12550 T12548 conj insertions,deletions
R10373 T12551 T12557 advcl have,are
R10374 T12552 T12553 amod permanent,effects
R10375 T12553 T12551 dobj effects,have
R10376 T12554 T12557 punct ",",are
R10377 T12555 T12556 amod reversible,mechanisms
R10378 T12556 T12557 nsubj mechanisms,are
R10379 T12557 T12557 ROOT are,are
R10380 T12558 T12559 compound gene,methylation
R10381 T12559 T12557 attr methylation,are
R10382 T12560 T12559 punct ",",methylation
R10383 T12561 T12559 cc or,methylation
R10384 T12562 T12559 conj expression,methylation
R10385 T12563 T12562 cc and,expression
R10386 T12564 T12562 conj activation,expression
R10387 T12565 T12562 prep of,expression
R10388 T12566 T12567 compound transcription,factors
R10389 T12567 T12565 pobj factors,of
R10390 T12568 T12559 punct ",",methylation
R10391 T12569 T12557 advmod respectively,are
R10392 T12570 T12557 punct .,are
R10393 T12571 T12572 nsubj We,studied
R10394 T12572 T12572 ROOT studied,studied
R10395 T12573 T12575 det a,cause
R10396 T12574 T12575 amod putative,cause
R10397 T12575 T12572 dobj cause,studied
R10398 T12576 T12575 prep for,cause
R10399 T12577 T12579 amod absent,expression
R10400 T12578 T12579 compound IRF-4,expression
R10401 T12579 T12576 pobj expression,for
R10402 T12580 T12579 prep in,expression
R10403 T12581 T12582 compound leukemia,cells
R10404 T12582 T12580 pobj cells,in
R10405 T12583 T12582 cc and,cells
R10406 T12584 T12585 advmod first,focused
R10407 T12585 T12572 conj focused,studied
R10408 T12586 T12585 prep on,focused
R10409 T12587 T12588 amod genetic,aberrations
R10410 T12588 T12586 pobj aberrations,on
R10411 T12589 T12588 prep of,aberrations
R10412 T12590 T12591 det the,promoter
R10413 T12591 T12589 pobj promoter,of
R10414 T12592 T12572 punct .,studied
R10415 T12593 T12594 nsubj We,observed
R10416 T12594 T12594 ROOT observed,observed
R10417 T12595 T12597 det no,alterations
R10418 T12596 T12597 amod genetic,alterations
R10419 T12597 T12594 dobj alterations,observed
R10420 T12598 T12597 prep in,alterations
R10421 T12599 T12601 det the,promoter
R10422 T12600 T12601 compound IRF-4,promoter
R10423 T12601 T12598 pobj promoter,in
R10424 T12602 T12601 punct ",",promoter
R10425 T12603 T12605 nsubj which,account
R10426 T12604 T12605 aux can,account
R10427 T12605 T12601 relcl account,promoter
R10428 T12606 T12605 prep for,account
R10429 T12607 T12608 det the,lack
R10430 T12608 T12606 pobj lack,for
R10431 T12609 T12608 prep of,lack
R10432 T12610 T12611 amod IRF-4,expression
R10433 T12611 T12609 pobj expression,of
R10434 T12612 T12597 punct :,alterations
R10435 T12613 T12617 det The,changes
R10436 T12614 T12617 amod detected,changes
R10437 T12615 T12616 compound base,pair
R10438 T12616 T12617 compound pair,changes
R10439 T12617 T12597 appos changes,alterations
R10440 T12618 T12617 prep at,changes
R10441 T12619 T12618 pobj position,at
R10442 T12620 T12626 nmod −,substitution
R10443 T12621 T12620 nummod 1081,−
R10444 T12622 T12623 punct (,T
R10445 T12623 T12626 dep T,substitution
R10446 T12624 T12626 nummod →,substitution
R10447 T12625 T12626 compound C,substitution
R10448 T12626 T12617 conj substitution,changes
R10449 T12627 T12626 punct ),substitution
R10450 T12628 T12626 punct ",",substitution
R10451 T12629 T12626 prep at,substitution
R10452 T12630 T12631 compound position,−
R10453 T12631 T12629 pobj −,at
R10454 T12632 T12631 nummod 1068,−
R10455 T12633 T12637 punct (,substitution
R10456 T12634 T12637 det A,substitution
R10457 T12635 T12637 compound →,substitution
R10458 T12636 T12637 compound C,substitution
R10459 T12637 T12637 ROOT substitution,substitution
R10460 T12638 T12637 punct ),substitution
R10461 T12639 T12637 cc and,substitution
R10462 T12640 T12650 prep at,are
R10463 T12641 T12640 pobj position,at
R10464 T12642 T12650 nsubj −,are
R10465 T12643 T12642 nummod 116,−
R10466 T12644 T12642 punct (,−
R10467 T12645 T12648 det A,substitution
R10468 T12646 T12648 compound →,substitution
R10469 T12647 T12648 compound C,substitution
R10470 T12648 T12642 appos substitution,−
R10471 T12649 T12642 punct ),−
R10472 T12650 T12637 conj are,substitution
R10473 T12651 T12652 amod unlikely,responsible
R10474 T12652 T12650 acomp responsible,are
R10475 T12653 T12652 prep for,responsible
R10476 T12654 T12655 amod absent,IRF-4-expression
R10477 T12655 T12653 pobj IRF-4-expression,for
R10478 T12656 T12662 mark since,found
R10479 T12657 T12660 det the,mutations
R10480 T12658 T12660 amod first,mutations
R10481 T12659 T12660 nummod two,mutations
R10482 T12660 T12662 nsubjpass mutations,found
R10483 T12661 T12662 auxpass were,found
R10484 T12662 T12650 advcl found,are
R10485 T12663 T12664 advmod both,in
R10486 T12664 T12662 prep in,found
R10487 T12665 T12669 amod IRF-4-positive,cells
R10488 T12666 T12665 cc and,IRF-4-positive
R10489 T12667 T12665 punct -,IRF-4-positive
R10490 T12668 T12669 amod negative,cells
R10491 T12669 T12664 pobj cells,in
R10492 T12670 T12676 mark whereas,detected
R10493 T12671 T12673 det the,change
R10494 T12672 T12673 amod latter,change
R10495 T12673 T12676 nsubjpass change,detected
R10496 T12674 T12676 auxpass was,detected
R10497 T12675 T12676 neg not,detected
R10498 T12676 T12650 advcl detected,are
R10499 T12677 T12676 advmod consistently,detected
R10500 T12678 T12676 prep in,detected
R10501 T12679 T12680 advmod all,IRF-4-negative
R10502 T12680 T12678 pobj IRF-4-negative,in
R10503 T12681 T12680 cc or,IRF-4-negative
R10504 T12682 T12683 punct -,positive
R10505 T12683 T12684 amod positive,cells
R10506 T12684 T12680 conj cells,IRF-4-negative
R10507 T12685 T12650 cc and,are
R10508 T12686 T12688 aux may,be
R10509 T12687 T12688 advmod thus,be
R10510 T12688 T12650 conj be,are
R10511 T12689 T12690 det a,polymorphism
R10512 T12690 T12688 attr polymorphism,be
R10513 T12691 T12637 punct .,substitution
R10514 T12692 T12694 det All,substitutions
R10515 T12693 T12694 nummod three,substitutions
R10516 T12694 T12697 nsubj substitutions,change
R10517 T12695 T12697 aux did,change
R10518 T12696 T12697 neg not,change
R10519 T12697 T12697 ROOT change,change
R10520 T12698 T12702 det any,factor
R10521 T12699 T12702 amod known,factor
R10522 T12700 T12702 amod putative,factor
R10523 T12701 T12702 compound transcription,factor
R10524 T12702 T12697 dobj factor,change
R10525 T12703 T12704 amod binding,sites
R10526 T12704 T12697 dobj sites,change
R10527 T12705 T12704 punct (,sites
R10528 T12706 T12704 appos "30,31",sites
R10529 T12707 T12704 punct ),sites
R10530 T12708 T12697 cc and,change
R10531 T12709 T12712 advmod also,affect
R10532 T12710 T12712 aux do,affect
R10533 T12711 T12712 neg not,affect
R10534 T12712 T12697 conj affect,change
R10535 T12713 T12715 det any,sites
R10536 T12714 T12715 compound restriction,sites
R10537 T12715 T12712 dobj sites,affect
R10538 T12716 T12715 cc or,sites
R10539 T12717 T12719 amod primer,sites
R10540 T12718 T12719 amod binding,sites
R10541 T12719 T12715 conj sites,sites
R10542 T12720 T12719 prep of,sites
R10543 T12721 T12723 det the,assays
R10544 T12722 T12723 amod used,assays
R10545 T12723 T12720 pobj assays,of
R10546 T12724 T12697 punct .,change
R10547 T12725 T12747 advmod However,excluded
R10548 T12726 T12747 punct ",",excluded
R10549 T12727 T12729 amod permanent,variations
R10550 T12728 T12729 amod genetic,variations
R10551 T12729 T12747 nsubjpass variations,excluded
R10552 T12730 T12729 prep in,variations
R10553 T12731 T12734 det the,sequence
R10554 T12732 T12734 amod IRF-4,sequence
R10555 T12733 T12734 amod coding,sequence
R10556 T12734 T12730 pobj sequence,in
R10557 T12735 T12734 punct ",",sequence
R10558 T12736 T12737 amod such,as
R10559 T12737 T12734 prep as,sequence
R10560 T12738 T12737 pobj deletions,as
R10561 T12739 T12738 cc or,deletions
R10562 T12740 T12738 conj mutations,deletions
R10563 T12741 T12738 acl resulting,deletions
R10564 T12742 T12741 prep in,resulting
R10565 T12743 T12742 pobj stop-codons,in
R10566 T12744 T12747 aux have,excluded
R10567 T12745 T12747 neg not,excluded
R10568 T12746 T12747 auxpass been,excluded
R10569 T12747 T12747 ROOT excluded,excluded
R10570 T12748 T12747 agent by,excluded
R10571 T12749 T12750 compound sequence,analysis
R10572 T12750 T12748 pobj analysis,by
R10573 T12751 T12747 punct .,excluded
R10574 T12752 T12762 prep Since,induced
R10575 T12753 T12754 compound IRF-4,expression
R10576 T12754 T12752 pobj expression,Since
R10577 T12755 T12754 prep in,expression
R10578 T12756 T12757 compound cell,lines
R10579 T12757 T12755 pobj lines,in
R10580 T12758 T12754 cc and,expression
R10581 T12759 T12762 nsubjpass CML,induced
R10582 T12760 T12762 aux can,induced
R10583 T12761 T12762 auxpass be,induced
R10584 T12762 T12781 advcl induced,seems
R10585 T12763 T12762 agent by,induced
R10586 T12764 T12763 pobj demethylation,by
R10587 T12765 T12764 cc and,demethylation
R10588 T12766 T12768 amod successful,therapy
R10589 T12767 T12768 compound IFN-α,therapy
R10590 T12768 T12764 conj therapy,demethylation
R10591 T12769 T12770 punct (,3
R10592 T12770 T12768 parataxis 3,therapy
R10593 T12771 T12770 punct ),3
R10594 T12772 T12770 punct ",",3
R10595 T12773 T12781 advmod respectively,seems
R10596 T12774 T12781 punct ",",seems
R10597 T12775 T12776 det the,existence
R10598 T12776 T12781 nsubj existence,seems
R10599 T12777 T12776 prep of,existence
R10600 T12778 T12780 amod such,aberrations
R10601 T12779 T12780 amod genetic,aberrations
R10602 T12780 T12777 pobj aberrations,of
R10603 T12781 T12781 ROOT seems,seems
R10604 T12782 T12781 oprd unlikely,seems
R10605 T12783 T12781 punct .,seems
R10606 T12784 T12786 nsubj We,investigated
R10607 T12785 T12786 advmod then,investigated
R10608 T12786 T12786 ROOT investigated,investigated
R10609 T12787 T12799 mark whether,was
R10610 T12788 T12791 det the,down-regulation
R10611 T12789 T12790 advmod previously,described
R10612 T12790 T12791 amod described,down-regulation
R10613 T12791 T12799 nsubj down-regulation,was
R10614 T12792 T12791 prep of,down-regulation
R10615 T12793 T12794 compound IRF-4,expression
R10616 T12794 T12792 pobj expression,of
R10617 T12795 T12791 prep in,down-regulation
R10618 T12796 T12798 amod human,leukemias
R10619 T12797 T12798 amod myeloid,leukemias
R10620 T12798 T12795 pobj leukemias,in
R10621 T12799 T12786 ccomp was,investigated
R10622 T12800 T12799 acomp due,was
R10623 T12801 T12800 prep to,due
R10624 T12802 T12804 det a,hypermethylation
R10625 T12803 T12804 compound differential,hypermethylation
R10626 T12804 T12801 pobj hypermethylation,to
R10627 T12805 T12804 prep of,hypermethylation
R10628 T12806 T12807 det the,promoter
R10629 T12807 T12805 pobj promoter,of
R10630 T12808 T12799 punct ",",was
R10631 T12809 T12818 mark since,be
R10632 T12810 T12812 det the,re-expression
R10633 T12811 T12812 amod presented,re-expression
R10634 T12812 T12818 nsubj re-expression,be
R10635 T12813 T12812 amod due,re-expression
R10636 T12814 T12813 prep to,due
R10637 T12815 T12814 pobj AzadC-treatment,to
R10638 T12816 T12818 aux might,be
R10639 T12817 T12818 advmod also,be
R10640 T12818 T12799 advcl be,was
R10641 T12819 T12820 det a,result
R10642 T12820 T12818 attr result,be
R10643 T12821 T12820 prep of,result
R10644 T12822 T12821 pobj activation,of
R10645 T12823 T12822 prep of,activation
R10646 T12824 T12826 amod positive,regulators
R10647 T12825 T12826 amod transcriptional,regulators
R10648 T12826 T12823 pobj regulators,of
R10649 T12827 T12826 prep of,regulators
R10650 T12828 T12827 pobj IRF-4,of
R10651 T12829 T12786 punct .,investigated
R10652 T12830 T12834 nsubj Methylation,is
R10653 T12831 T12830 prep of,Methylation
R10654 T12832 T12833 compound CpG,sites
R10655 T12833 T12831 pobj sites,of
R10656 T12834 T12834 ROOT is,is
R10657 T12835 T12837 det a,mechanism
R10658 T12836 T12837 amod common,mechanism
R10659 T12837 T12834 attr mechanism,is
R10660 T12838 T12837 prep of,mechanism
R10661 T12839 T12838 pcomp silencing,of
R10662 T12840 T12839 dobj genes,silencing
R10663 T12841 T12839 prep in,silencing
R10664 T12842 T12841 pobj leukemia,in
R10665 T12843 T12834 cc and,is
R10666 T12844 T12847 aux has,shown
R10667 T12845 T12847 advmod also,shown
R10668 T12846 T12847 auxpass been,shown
R10669 T12847 T12834 conj shown,is
R10670 T12848 T12847 prep for,shown
R10671 T12849 T12850 det another,IRF
R10672 T12850 T12848 pobj IRF,for
R10673 T12851 T12850 punct ",",IRF
R10674 T12852 T12850 conj IRF-7,IRF
R10675 T12853 T12852 punct (,IRF-7
R10676 T12854 T12852 appos 35,IRF-7
R10677 T12855 T12852 punct ),IRF-7
R10678 T12856 T12848 cc and,for
R10679 T12857 T12848 conj for,for
R10680 T12858 T12857 pobj PU,for
R10681 T12859 T12858 nummod .1,PU
R10682 T12860 T12858 punct (,PU
R10683 T12861 T12858 nummod 36,PU
R10684 T12862 T12858 punct ),PU
R10685 T12863 T12847 punct ",",shown
R10686 T12864 T12866 det an,partner
R10687 T12865 T12866 amod interacting,partner
R10688 T12866 T12847 dobj partner,shown
R10689 T12867 T12866 prep of,partner
R10690 T12868 T12867 pobj IRF-4,of
R10691 T12869 T12834 punct .,is
R10692 T12870 T12871 aux To,elucidate
R10693 T12871 T12888 advcl elucidate,treated
R10694 T12872 T12873 det the,relevance
R10695 T12873 T12871 dobj relevance,elucidate
R10696 T12874 T12873 prep of,relevance
R10697 T12875 T12876 det this,mechanism
R10698 T12876 T12874 pobj mechanism,of
R10699 T12877 T12873 prep for,relevance
R10700 T12878 T12879 det the,regulation
R10701 T12879 T12877 pobj regulation,for
R10702 T12880 T12879 prep of,regulation
R10703 T12881 T12882 compound IRF-4,expression
R10704 T12882 T12880 pobj expression,of
R10705 T12883 T12888 punct ",",treated
R10706 T12884 T12886 amod various,cells
R10707 T12885 T12886 amod leukemic,cells
R10708 T12886 T12888 nsubjpass cells,treated
R10709 T12887 T12888 auxpass were,treated
R10710 T12888 T12888 ROOT treated,treated
R10711 T12889 T12888 prep with,treated
R10712 T12890 T12891 amod demethylating,agents
R10713 T12891 T12889 pobj agents,with
R10714 T12892 T12891 cc and,agents
R10715 T12893 T12891 conj promoters,agents
R10716 T12894 T12895 auxpass were,sequenced
R10717 T12895 T12895 ROOT sequenced,sequenced
R10718 T12896 T12895 prep after,sequenced
R10719 T12897 T12898 amod bisulfite,treatment
R10720 T12898 T12896 pobj treatment,after
R10721 T12899 T12895 punct .,sequenced
R10722 T12900 T12901 nsubj We,found
R10723 T12901 T12901 ROOT found,found
R10724 T12902 T12908 mark that,connected
R10725 T12903 T12904 amod IRF-4,expression
R10726 T12904 T12908 nsubjpass expression,connected
R10727 T12905 T12908 aux could,connected
R10728 T12906 T12908 advmod indeed,connected
R10729 T12907 T12908 auxpass be,connected
R10730 T12908 T12901 ccomp connected,found
R10731 T12909 T12908 prep to,connected
R10732 T12910 T12912 det the,status
R10733 T12911 T12912 amod methylation,status
R10734 T12912 T12909 pobj status,to
R10735 T12913 T12912 prep of,status
R10736 T12914 T12916 amod distinct,motifs
R10737 T12915 T12916 compound CpG,motifs
R10738 T12916 T12913 pobj motifs,of
R10739 T12917 T12912 prep in,status
R10740 T12918 T12920 det the,promoter
R10741 T12919 T12920 compound IRF-4,promoter
R10742 T12920 T12917 pobj promoter,in
R10743 T12921 T12901 punct .,found
R10744 T12922 T12930 prep In,shown
R10745 T12923 T12924 compound Figure,4A
R10746 T12924 T12922 pobj 4A,In
R10747 T12925 T12930 punct ",",shown
R10748 T12926 T12928 det those,sites
R10749 T12927 T12928 compound CpG,sites
R10750 T12928 T12930 nsubjpass sites,shown
R10751 T12929 T12930 auxpass are,shown
R10752 T12930 T12930 ROOT shown,shown
R10753 T12931 T12930 punct (,shown
R10754 T12932 T12933 amod bottom,line
R10755 T12933 T12930 dobj line,shown
R10756 T12934 T12930 punct ),shown
R10757 T12935 T12930 punct ",",shown
R10758 T12936 T12937 poss whose,hypermethylation
R10759 T12937 T12939 nsubj hypermethylation,account
R10760 T12938 T12939 aux may,account
R10761 T12939 T12930 ccomp account,shown
R10762 T12940 T12939 prep for,account
R10763 T12941 T12942 det the,absence
R10764 T12942 T12940 pobj absence,for
R10765 T12943 T12942 prep of,absence
R10766 T12944 T12945 compound IRF-4,expression
R10767 T12945 T12943 pobj expression,of
R10768 T12946 T12942 prep in,absence
R10769 T12947 T12949 det the,cells
R10770 T12948 T12949 amod respective,cells
R10771 T12949 T12946 pobj cells,in
R10772 T12950 T12930 punct .,shown
R10773 T12951 T12958 nsubj One,is
R10774 T12952 T12951 prep of,One
R10775 T12953 T12952 pobj them,of
R10776 T12954 T12953 punct (,them
R10777 T12955 T12956 nmod #,54
R10778 T12956 T12953 appos 54,them
R10779 T12957 T12951 punct ),One
R10780 T12958 T12958 ROOT is,is
R10781 T12959 T12958 acomp adjacent,is
R10782 T12960 T12959 prep to,adjacent
R10783 T12961 T12964 det an,element
R10784 T12962 T12964 amod identified,element
R10785 T12963 T12964 amod regulatory,element
R10786 T12964 T12960 pobj element,to
R10787 T12965 T12966 punct (,NFκB-site
R10788 T12966 T12964 appos NFκB-site,element
R10789 T12967 T12958 punct ),is
R10790 T12968 T12958 punct ",",is
R10791 T12969 T12958 advcl indicating,is
R10792 T12970 T12972 det a,involvement
R10793 T12971 T12972 amod possible,involvement
R10794 T12972 T12969 dobj involvement,indicating
R10795 T12973 T12972 prep of,involvement
R10796 T12974 T12975 det this,site
R10797 T12975 T12973 pobj site,of
R10798 T12976 T12958 punct .,is
R10799 T12977 T12993 prep At,was
R10800 T12978 T12981 nummod two,sites
R10801 T12979 T12981 amod further,sites
R10802 T12980 T12981 compound CpG,sites
R10803 T12981 T12977 pobj sites,At
R10804 T12982 T12981 punct (,sites
R10805 T12983 T12993 meta #,was
R10806 T12984 T12983 nummod 48,#
R10807 T12985 T12983 punct ",",#
R10808 T12986 T12983 appos 45,#
R10809 T12987 T12983 punct ),#
R10810 T12988 T12990 det the,status
R10811 T12989 T12990 compound methylation,status
R10812 T12990 T12993 nsubj status,was
R10813 T12991 T12990 prep in,status
R10814 T12992 T12991 pobj IRF-4-positive,in
R10815 T12993 T12993 ROOT was,was
R10816 T12994 T12993 acomp lower,was
R10817 T12995 T12994 prep than,lower
R10818 T12996 T12995 pobj that,than
R10819 T12997 T12996 prep of,that
R10820 T12998 T12999 amod IRF-4-negative,cells
R10821 T12999 T12997 pobj cells,of
R10822 T13000 T12993 punct .,was
R10823 T13001 T13003 det These,sites
R10824 T13002 T13003 compound CpG,sites
R10825 T13003 T13005 nsubjpass sites,located
R10826 T13004 T13005 auxpass are,located
R10827 T13005 T13005 ROOT located,located
R10828 T13006 T13005 prep in,located
R10829 T13007 T13008 det an,NFκB
R10830 T13008 T13006 pobj NFκB,in
R10831 T13009 T13005 cc and,located
R10832 T13010 T13012 det an,element
R10833 T13011 T13012 nummod SP1,element
R10834 T13012 T13005 conj element,located
R10835 T13013 T13012 punct (,element
R10836 T13014 T13012 appos 31,element
R10837 T13015 T13012 punct ),element
R10838 T13016 T13005 cc and,located
R10839 T13017 T13020 advmod thus,play
R10840 T13018 T13020 aux may,play
R10841 T13019 T13020 advmod also,play
R10842 T13020 T13005 conj play,located
R10843 T13021 T13022 det a,role
R10844 T13022 T13020 dobj role,play
R10845 T13023 T13022 prep in,role
R10846 T13024 T13023 pobj regulation,in
R10847 T13025 T13024 prep of,regulation
R10848 T13026 T13027 amod IRF-4,expression
R10849 T13027 T13025 pobj expression,of
R10850 T13028 T13005 punct .,located
R10851 T13029 T13032 nsubjpass It,shown
R10852 T13030 T13032 aux has,shown
R10853 T13031 T13032 auxpass been,shown
R10854 T13032 T13032 ROOT shown,shown
R10855 T13033 T13036 mark that,play
R10856 T13034 T13035 compound NFκB,elements
R10857 T13035 T13036 nsubj elements,play
R10858 T13036 T13032 ccomp play,shown
R10859 T13037 T13039 det an,role
R10860 T13038 T13039 amod important,role
R10861 T13039 T13036 dobj role,play
R10862 T13040 T13039 prep in,role
R10863 T13041 T13042 compound IRF-4,induction
R10864 T13042 T13040 pobj induction,in
R10865 T13043 T13046 mark as,depends
R10866 T13044 T13045 amod IRF-4,expression
R10867 T13045 T13046 nsubj expression,depends
R10868 T13046 T13036 advcl depends,play
R10869 T13047 T13046 prep on,depends
R10870 T13048 T13047 pobj binding,on
R10871 T13049 T13048 prep of,binding
R10872 T13050 T13052 det the,c-Rel
R10873 T13051 T13052 compound transactivator,c-Rel
R10874 T13052 T13049 pobj c-Rel,of
R10875 T13053 T13052 prep to,c-Rel
R10876 T13054 T13055 det these,elements
R10877 T13055 T13053 pobj elements,to
R10878 T13056 T13055 prep in,elements
R10879 T13057 T13059 det the,promoter
R10880 T13058 T13059 compound IRF-4,promoter
R10881 T13059 T13056 pobj promoter,in
R10882 T13060 T13059 punct (,promoter
R10883 T13061 T13059 appos "31,37",promoter
R10884 T13062 T13059 punct ),promoter
R10885 T13063 T13032 punct .,shown
R10886 T13064 T13075 advmod Furthermore,inhibits
R10887 T13065 T13075 punct ",",inhibits
R10888 T13066 T13075 nsubj methylation,inhibits
R10889 T13067 T13066 prep of,methylation
R10890 T13068 T13070 det the,CpG
R10891 T13069 T13070 amod central,CpG
R10892 T13070 T13067 pobj CpG,of
R10893 T13071 T13066 prep in,methylation
R10894 T13072 T13074 det the,element
R10895 T13073 T13074 compound NFκB,element
R10896 T13074 T13071 pobj element,in
R10897 T13075 T13075 ROOT inhibits,inhibits
R10898 T13076 T13075 dobj binding,inhibits
R10899 T13077 T13076 prep of,binding
R10900 T13078 T13081 det the,complexes
R10901 T13079 T13080 compound NFκB,protein
R10902 T13080 T13081 compound protein,complexes
R10903 T13081 T13077 pobj complexes,of
R10904 T13082 T13081 punct (,complexes
R10905 T13083 T13081 appos 38,complexes
R10906 T13084 T13081 punct ),complexes
R10907 T13085 T13075 punct ",",inhibits
R10908 T13086 T13075 advcl promoting,inhibits
R10909 T13087 T13088 det the,significance
R10910 T13088 T13086 dobj significance,promoting
R10911 T13089 T13088 prep of,significance
R10912 T13090 T13093 det the,differences
R10913 T13091 T13093 amod observed,differences
R10914 T13092 T13093 compound methylation,differences
R10915 T13093 T13089 pobj differences,of
R10916 T13094 T13093 prep in,differences
R10917 T13095 T13094 pobj IRF-4-positive,in
R10918 T13096 T13088 cc and,significance
R10919 T13097 T13098 punct -,negative
R10920 T13098 T13099 amod negative,cells
R10921 T13099 T13088 conj cells,significance
R10922 T13100 T13075 punct .,inhibits
R10923 T13101 T13112 npadvmod Via,appoint
R10924 T13102 T13112 prep in,appoint
R10925 T13103 T13104 amod vitro,methylation
R10926 T13104 T13102 pobj methylation,in
R10927 T13105 T13104 cc and,methylation
R10928 T13106 T13107 compound reporter,gene
R10929 T13107 T13108 compound gene,assays
R10930 T13108 T13102 pobj assays,in
R10931 T13109 T13112 nsubj we,appoint
R10932 T13110 T13112 aux could,appoint
R10933 T13111 T13112 advmod clearly,appoint
R10934 T13112 T13112 ROOT appoint,appoint
R10935 T13113 T13114 det the,silencing
R10936 T13114 T13112 dobj silencing,appoint
R10937 T13115 T13114 prep of,silencing
R10938 T13116 T13118 det the,promoter
R10939 T13117 T13118 compound IRF-4,promoter
R10940 T13118 T13115 pobj promoter,of
R10941 T13119 T13112 prep to,appoint
R10942 T13120 T13122 det a,effect
R10943 T13121 T13122 compound methylation,effect
R10944 T13122 T13119 pobj effect,to
R10945 T13123 T13122 punct ",",effect
R10946 T13124 T13127 nsubj which,be
R10947 T13125 T13127 aux may,be
R10948 T13126 T13127 advmod thus,be
R10949 T13127 T13122 relcl be,effect
R10950 T13128 T13129 det the,mechanism
R10951 T13129 T13127 attr mechanism,be
R10952 T13130 T13129 prep of,mechanism
R10953 T13131 T13132 compound IRF-4,deregulation
R10954 T13132 T13130 pobj deregulation,of
R10955 T13133 T13132 prep in,deregulation
R10956 T13134 T13133 pobj vivo,in
R10957 T13135 T13112 punct .,appoint
R10958 T13136 T13138 nummod One,cause
R10959 T13137 T13138 amod possible,cause
R10960 T13138 T13145 nsubj cause,is
R10961 T13139 T13138 prep for,cause
R10962 T13140 T13142 det the,methylation
R10963 T13141 T13142 amod aberrant,methylation
R10964 T13142 T13139 pobj methylation,for
R10965 T13143 T13142 prep in,methylation
R10966 T13144 T13143 pobj tumorigenesis,in
R10967 T13145 T13145 ROOT is,is
R10968 T13146 T13148 det an,level
R10969 T13147 T13148 amod increased,level
R10970 T13148 T13145 attr level,is
R10971 T13149 T13148 prep of,level
R10972 T13150 T13149 pobj DNMTs,of
R10973 T13151 T13148 prep during,level
R10974 T13152 T13154 det the,process
R10975 T13153 T13154 amod pathogenetic,process
R10976 T13154 T13151 pobj process,during
R10977 T13155 T13145 punct .,is
R10978 T13156 T13174 prep In,detected
R10979 T13157 T13156 pobj colon,In
R10980 T13158 T13157 punct ",",colon
R10981 T13159 T13157 conj lung,colon
R10982 T13160 T13159 cc and,lung
R10983 T13161 T13162 amod hematologic,malignancies
R10984 T13162 T13159 conj malignancies,lung
R10985 T13163 T13157 punct ",",colon
R10986 T13164 T13174 nsubj overexpression,detected
R10987 T13165 T13164 prep of,overexpression
R10988 T13166 T13165 pobj DNMT1,of
R10989 T13167 T13166 punct ",",DNMT1
R10990 T13168 T13170 det a,DNMT
R10991 T13199 T13200 amod known,DNMTs
R10992 T13169 T13170 compound maintenance,DNMT
R10993 T13200 T13196 pobj DNMTs,of
R10994 T13201 T13193 punct ",",exhibited
R10995 T13170 T13166 appos DNMT,DNMT1
R10996 T13202 T13208 mark while,expressed
R10997 T13203 T13204 compound CML,cells
R10998 T13171 T13174 punct ",",detected
R10999 T13204 T13208 nsubj cells,expressed
R11000 T13205 T13204 prep in,cells
R11001 T13206 T13207 amod chronic,phase
R11002 T13172 T13174 aux has,detected
R11003 T13207 T13205 pobj phase,in
R11004 T13208 T13193 advcl expressed,exhibited
R11005 T13209 T13210 amod normal,levels
R11006 T13173 T13174 auxpass been,detected
R11007 T13210 T13208 dobj levels,expressed
R11008 T13211 T13210 prep of,levels
R11009 T13212 T13211 pobj DNMTs,of
R11010 T13174 T13174 ROOT detected,detected
R11011 T13213 T13214 mark if,compared
R11012 T13214 T13208 advcl compared,expressed
R11013 T13215 T13214 prep with,compared
R11014 T13175 T13174 punct (,detected
R11015 T13216 T13219 amod normal,cells
R11016 T13217 T13218 compound bone,marrow
R11017 T13218 T13219 compound marrow,cells
R11018 T13219 T13215 pobj cells,with
R11019 T13220 T13221 punct (,25
R11020 T13176 T13177 nummod 39,41
R11021 T13221 T13219 appos 25,cells
R11022 T13222 T13219 punct ),cells
R11023 T13223 T13185 punct .,shown
R11024 T13177 T13174 npadvmod 41,detected
R11025 T13224 T13239 advmod Interestingly,detected
R11026 T13225 T13239 punct ",",detected
R11027 T13226 T13228 det a,correlation
R11028 T13178 T13174 punct ),detected
R11029 T13227 T13228 amod positive,correlation
R11030 T13179 T13174 punct .,detected
R11031 T13228 T13239 nsubjpass correlation,detected
R11032 T13229 T13228 prep between,correlation
R11033 T13230 T13232 nummod DNMT1,levels
R11034 T13231 T13232 compound expression,levels
R11035 T13232 T13229 pobj levels,between
R11036 T13180 T13185 advmod Furthermore,shown
R11037 T13233 T13232 cc and,levels
R11038 T13181 T13185 punct ",",shown
R11039 T13182 T13185 nsubjpass it,shown
R11040 T13234 T13232 conj hypermethylation,levels
R11041 T13235 T13234 prep of,hypermethylation
R11042 T13183 T13185 aux has,shown
R11043 T13236 T13235 pobj p15INK4b,of
R11044 T13237 T13239 aux has,detected
R11045 T13238 T13239 auxpass been,detected
R11046 T13184 T13185 auxpass been,shown
R11047 T13239 T13239 ROOT detected,detected
R11048 T13240 T13239 prep in,detected
R11049 T13241 T13240 pobj AML,in
R11050 T13185 T13185 ROOT shown,shown
R11051 T13242 T13243 punct (,25
R11052 T13243 T13239 npadvmod 25,detected
R11053 T13244 T13243 punct ),25
R11054 T13186 T13193 mark that,exhibited
R11055 T13245 T13239 punct .,detected
R11056 T13246 T13253 prep In,detect
R11057 T13247 T13248 det this,work
R11058 T13187 T13188 compound CML,cells
R11059 T13248 T13246 pobj work,In
R11060 T13249 T13253 punct ",",detect
R11061 T13188 T13193 nsubj cells,exhibited
R11062 T13250 T13253 nsubj we,detect
R11063 T13251 T13253 aux did,detect
R11064 T13252 T13253 neg not,detect
R11065 T13189 T13188 prep in,cells
R11066 T13253 T13253 ROOT detect,detect
R11067 T13254 T13257 amod significant,differences
R11068 T13255 T13256 compound mRNA,expression
R11069 T13256 T13257 compound expression,differences
R11070 T13257 T13253 dobj differences,detect
R11071 T13258 T13257 prep of,differences
R11072 T13190 T13192 det the,phase
R11073 T13259 T13260 amod selected,DNMT
R11074 T13260 T13258 pobj DNMT,of
R11075 T13261 T13260 cc or,DNMT
R11076 T13191 T13192 amod acute,phase
R11077 T13262 T13260 conj MBP,DNMT
R11078 T13263 T13253 punct ",",detect
R11079 T13192 T13189 pobj phase,in
R11080 T13264 T13253 advcl making,detect
R11081 T13265 T13268 nsubj it,cause
R11082 T13193 T13185 ccomp exhibited,shown
R11083 T13266 T13268 det an,cause
R11084 T13267 T13268 amod unlikely,cause
R11085 T13268 T13264 ccomp cause,making
R11086 T13194 T13195 amod elevated,levels
R11087 T13269 T13268 prep for,cause
R11088 T13270 T13272 det the,methylation
R11089 T13271 T13272 amod observed,methylation
R11090 T13195 T13193 dobj levels,exhibited
R11091 T13272 T13269 pobj methylation,for
R11092 T13273 T13269 cc and,for
R11093 T13196 T13195 prep of,levels
R11094 T13274 T13277 advmod thus,differences
R11095 T13275 T13277 amod IRF-4,differences
R11096 T13276 T13277 compound expression,differences
R11097 T13277 T13268 dep differences,cause
R11098 T13197 T13200 det the,DNMTs
R11099 T13278 T13277 prep in,differences
R11100 T13279 T13280 compound leukemia,cells
R11101 T13280 T13278 pobj cells,in
R11102 T13198 T13200 nummod three,DNMTs
R11103 T13281 T13253 punct .,detect
R11104 T13282 T13283 det The,finding
R11105 T13296 T13297 nsubj that,accounts
R11106 T13283 T13293 nsubj finding,represent
R11107 T13284 T13288 mark that,silenced
R11108 T13297 T13295 relcl accounts,mechanism
R11109 T13285 T13286 compound IRF-4,expression
R11110 T13286 T13288 nsubjpass expression,silenced
R11111 T13287 T13288 auxpass is,silenced
R11112 T13298 T13297 prep for,accounts
R11113 T13288 T13283 acl silenced,finding
R11114 T13289 T13288 agent by,silenced
R11115 T13290 T13291 compound promoter,hypermethylation
R11116 T13291 T13289 pobj hypermethylation,by
R11117 T13292 T13293 aux might,represent
R11118 T13293 T13293 ROOT represent,represent
R11119 T13294 T13295 det a,mechanism
R11120 T13299 T13302 det the,loss
R11121 T13295 T13293 dobj mechanism,represent
R11122 T13300 T13301 advmod previously,observed
R11123 T13301 T13302 amod observed,loss
R11124 T13302 T13298 pobj loss,for
R11125 T13303 T13302 prep of,loss
R11126 T13304 T13305 compound IRF-4,expression
R11127 T13305 T13303 pobj expression,of
R11128 T13306 T13302 prep in,loss
R11129 T13307 T13306 pobj CML,in
R11130 T13393 T13379 prep by,reverted
R11131 T13394 T13393 pobj treatment,by
R11132 T13308 T13293 punct .,represent
R11133 T13395 T13379 prep with,reverted
R11134 T13396 T13395 pobj AzadC,with
R11135 T13397 T13398 punct (,Figure
R11136 T13309 T13322 advmod Indeed,demonstrated
R11137 T13398 T13396 appos Figure,AzadC
R11138 T13399 T13398 nummod 6,Figure
R11139 T13310 T13322 punct ",",demonstrated
R11140 T13400 T13398 punct ),Figure
R11141 T13401 T13396 cc and,AzadC
R11142 T13311 T13313 amod several,trials
R11143 T13402 T13396 conj AzadC,AzadC
R11144 T13403 T13379 conj has,reverted
R11145 T13312 T13313 amod clinical,trials
R11146 T13404 T13405 det no,effect
R11147 T13405 T13403 dobj effect,has
R11148 T13406 T13405 prep on,effect
R11149 T13313 T13322 nsubj trials,demonstrated
R11150 T13407 T13408 compound ICSBP,levels
R11151 T13408 T13406 pobj levels,on
R11152 T13409 T13408 prep in,levels
R11153 T13410 T13412 amod ICSBP-positive,cells
R11154 T13411 T13412 compound U-937,cells
R11155 T13314 T13313 prep with,trials
R11156 T13412 T13409 pobj cells,in
R11157 T13413 T13414 punct (,Figure
R11158 T13414 T13412 appos Figure,cells
R11159 T13315 T13316 compound leukemia,patients
R11160 T13415 T13414 nummod 6,Figure
R11161 T13416 T13414 punct ),Figure
R11162 T13417 T13379 punct .,reverted
R11163 T13316 T13314 pobj patients,with
R11164 T13418 T13419 det These,data
R11165 T13419 T13420 nsubj data,suggest
R11166 T13420 T13420 ROOT suggest,suggest
R11167 T13421 T13424 det a,mechanism
R11168 T13422 T13424 amod distinct,mechanism
R11169 T13423 T13424 amod regulatory,mechanism
R11170 T13317 T13316 cc and,patients
R11171 T13424 T13420 dobj mechanism,suggest
R11172 T13425 T13424 prep for,mechanism
R11173 T13426 T13428 det these,IRFs
R11174 T13318 T13316 conj patients,patients
R11175 T13427 T13428 nummod two,IRFs
R11176 T13428 T13425 pobj IRFs,for
R11177 T13429 T13420 punct .,suggest
R11178 T13430 T13448 nsubj IRF-4,be
R11179 T13319 T13318 prep with,patients
R11180 T13431 T13430 punct ",",IRF-4
R11181 T13432 T13430 amod similar,IRF-4
R11182 T13433 T13432 prep to,similar
R11183 T13320 T13321 amod myelodysplastic,syndromes
R11184 T13434 T13439 amod many,genes
R11185 T13435 T13439 amod other,genes
R11186 T13321 T13319 pobj syndromes,with
R11187 T13436 T13439 amod classical,genes
R11188 T13437 T13438 compound tumor,suppressor
R11189 T13438 T13439 compound suppressor,genes
R11190 T13322 T13322 ROOT demonstrated,demonstrated
R11191 T13439 T13433 pobj genes,to
R11192 T13440 T13439 appos p15INK4b,genes
R11193 T13441 T13440 punct ",",p15INK4b
R11194 T13323 T13326 det the,benefit
R11195 T13442 T13440 conj p16INK4a,p15INK4b
R11196 T13443 T13442 cc or,p16INK4a
R11197 T13444 T13442 conj p53,p16INK4a
R11198 T13324 T13326 amod potential,benefit
R11199 T13445 T13448 punct ",",be
R11200 T13446 T13448 aux may,be
R11201 T13325 T13326 amod clinical,benefit
R11202 T13447 T13448 advmod thus,be
R11203 T13448 T13448 ROOT be,be
R11204 T13449 T13450 det a,subject
R11205 T13326 T13322 dobj benefit,demonstrated
R11206 T13450 T13448 attr subject,be
R11207 T13451 T13450 prep of,subject
R11208 T13452 T13451 pobj alterations,of
R11209 T13327 T13326 prep of,benefit
R11210 T13453 T13452 prep in,alterations
R11211 T13454 T13457 det the,status
R11212 T13455 T13457 compound promoter,status
R11213 T13328 T13329 det a,treatment
R11214 T13456 T13457 compound methylation,status
R11215 T13457 T13453 pobj status,in
R11216 T13458 T13450 acl leading,subject
R11217 T13459 T13458 prep to,leading
R11218 T13460 T13461 compound expression,changes
R11219 T13461 T13459 pobj changes,to
R11220 T13462 T13461 punct ",",changes
R11221 T13329 T13327 pobj treatment,of
R11222 T13463 T13465 nsubj which,contribute
R11223 T13464 T13465 aux might,contribute
R11224 T13465 T13461 relcl contribute,changes
R11225 T13330 T13329 prep with,treatment
R11226 T13466 T13465 prep to,contribute
R11227 T13467 T13468 det the,initiation
R11228 T13468 T13466 pobj initiation,to
R11229 T13331 T13332 amod demethylating,agents
R11230 T13469 T13468 cc and/or,initiation
R11231 T13470 T13468 conj progression,initiation
R11232 T13332 T13330 pobj agents,with
R11233 T13333 T13332 punct (,agents
R11234 T13334 T13332 appos 42,agents
R11235 T13471 T13468 prep of,initiation
R11236 T13472 T13471 pobj cancer,of
R11237 T13473 T13448 punct .,be
R11238 T13335 T13332 appos 45,agents
R11239 T13336 T13332 punct ),agents
R11240 T13337 T13322 punct .,demonstrated
R11241 T13474 T13482 advmod Still,remains
R11242 T13475 T13482 punct ",",remains
R11243 T13338 T13339 det The,expression
R11244 T13476 T13479 det the,diversity
R11245 T13477 T13479 amod obvious,diversity
R11246 T13339 T13355 nsubjpass expression,impaired
R11247 T13478 T13479 amod functional,diversity
R11248 T13479 T13482 nsubj diversity,remains
R11249 T13480 T13479 prep of,diversity
R11250 T13340 T13339 prep of,expression
R11251 T13481 T13480 pobj IRF-4,of
R11252 T13482 T13482 ROOT remains,remains
R11253 T13341 T13355 det another,impaired
R11254 T13483 T13482 acomp remarkable,remains
R11255 T13484 T13482 cc and,remains
R11256 T13485 T13489 aux can,explained
R11257 T13342 T13355 npadvmod IRF,impaired
R11258 T13486 T13489 neg not,explained
R11259 T13487 T13489 auxpass be,explained
R11260 T13488 T13489 advmod fully,explained
R11261 T13343 T13355 punct ",",impaired
R11262 T13489 T13482 conj explained,remains
R11263 T13344 T13346 compound IFN,sequence
R11264 T13345 T13346 compound consensus,sequence
R11265 T13346 T13355 nsubjpass sequence,impaired
R11266 T13490 T13489 agent by,explained
R11267 T13347 T13348 amod binding,protein
R11268 T13491 T13495 det the,status
R11269 T13492 T13495 amod IRF-4,status
R11270 T13493 T13495 compound promoter,status
R11271 T13494 T13495 compound methylation,status
R11272 T13495 T13490 pobj status,by
R11273 T13496 T13482 punct .,remains
R11274 T13348 T13346 dobj protein,sequence
R11275 T13497 T13503 prep For,known
R11276 T13498 T13497 pobj example,For
R11277 T13499 T13503 punct ",",known
R11278 T13349 T13350 punct (,ICSBP/IRF
R11279 T13500 T13503 nsubjpass IRF-4,known
R11280 T13501 T13503 auxpass is,known
R11281 T13350 T13348 appos ICSBP/IRF,protein
R11282 T13502 T13503 advmod primarily,known
R11283 T13503 T13503 ROOT known,known
R11284 T13504 T13503 prep for,known
R11285 T13351 T13350 nummod -8,ICSBP/IRF
R11286 T13505 T13507 poss its,features
R11287 T13506 T13507 amod oncogenic,features
R11288 T13507 T13504 pobj features,for
R11289 T13352 T13350 punct ),ICSBP/IRF
R11290 T13508 T13503 punct .,known
R11291 T13509 T13521 prep In,reported
R11292 T13510 T13511 amod multiple,myeloma
R11293 T13353 T13355 punct ",",impaired
R11294 T13511 T13509 pobj myeloma,In
R11295 T13512 T13513 punct (,MM
R11296 T13354 T13355 auxpass is,impaired
R11297 T13513 T13511 appos MM,myeloma
R11298 T13514 T13513 punct ),MM
R11299 T13515 T13516 det a,translocation
R11300 T13516 T13521 nsubjpass translocation,reported
R11301 T13517 T13516 prep on,translocation
R11302 T13355 T13355 ROOT impaired,impaired
R11303 T13518 T13517 pobj chromosome,on
R11304 T13519 T13518 nummod 14q,chromosome
R11305 T13520 T13521 auxpass was,reported
R11306 T13521 T13521 ROOT reported,reported
R11307 T13356 T13355 prep in,impaired
R11308 T13522 T13523 aux to,lead
R11309 T13523 T13521 xcomp lead,reported
R11310 T13524 T13523 prep to,lead
R11311 T13357 T13358 amod myeloid,leukemias
R11312 T13525 T13527 det a,gene
R11313 T13526 T13527 compound fusion,gene
R11314 T13527 T13524 pobj gene,to
R11315 T13358 T13356 pobj leukemias,in
R11316 T13528 T13527 prep of,gene
R11317 T13529 T13530 compound immunoglobulin,heavy-chain
R11318 T13530 T13528 pobj heavy-chain,of
R11319 T13531 T13532 punct (,IgH
R11320 T13532 T13530 appos IgH,heavy-chain
R11321 T13533 T13532 punct ),IgH
R11322 T13359 T13360 advmod especially,CML
R11323 T13534 T13530 cc and,heavy-chain
R11324 T13535 T13530 conj IRF-4,heavy-chain
R11325 T13536 T13527 acl resulting,gene
R11326 T13360 T13358 appos CML,leukemias
R11327 T13537 T13536 prep in,resulting
R11328 T13538 T13540 det a,overexpression
R11329 T13361 T13360 punct (,CML
R11330 T13539 T13540 amod subsequent,overexpression
R11331 T13540 T13537 pobj overexpression,in
R11332 T13541 T13540 prep of,overexpression
R11333 T13362 T13360 appos "27,46,47",CML
R11334 T13542 T13541 pobj IRF-4,of
R11335 T13543 T13544 punct (,"48,49"
R11336 T13544 T13542 parataxis "48,49",IRF-4
R11337 T13363 T13360 punct ),CML
R11338 T13545 T13540 punct ),overexpression
R11339 T13546 T13521 punct .,reported
R11340 T13364 T13355 punct .,impaired
R11341 T13547 T13554 prep In,found
R11342 T13548 T13547 pobj addition,In
R11343 T13549 T13554 punct ",",found
R11344 T13365 T13379 cc But,reverted
R11345 T13550 T13552 amod abundant,expression
R11346 T13366 T13379 prep in,reverted
R11347 T13367 T13366 pobj contrast,in
R11348 T13551 T13552 compound IRF-4,expression
R11349 T13368 T13367 prep to,contrast
R11350 T13369 T13368 pobj IRF-4,to
R11351 T13552 T13554 nsubjpass expression,found
R11352 T13370 T13369 punct ",",IRF-4
R11353 T13553 T13554 auxpass was,found
R11354 T13371 T13372 det the,loss
R11355 T13554 T13554 ROOT found,found
R11356 T13555 T13556 aux to,be
R11357 T13556 T13554 xcomp be,found
R11358 T13557 T13558 det a,marker
R11359 T13372 T13369 appos loss,IRF-4
R11360 T13558 T13556 attr marker,be
R11361 T13559 T13558 prep for,marker
R11362 T13373 T13372 prep of,loss
R11363 T13560 T13561 amod various,subsets
R11364 T13561 T13559 pobj subsets,for
R11365 T13374 T13375 det this,IRF
R11366 T13562 T13561 prep of,subsets
R11367 T13563 T13562 pobj lymphomas,of
R11368 T13564 T13563 punct ",",lymphomas
R11369 T13565 T13566 amod such,as
R11370 T13566 T13563 prep as,lymphomas
R11371 T13567 T13566 pobj diffuse,as
R11372 T13375 T13373 pobj IRF,of
R11373 T13568 T13570 amod large,lymphomas
R11374 T13569 T13570 compound B-cell,lymphomas
R11375 T13570 T13567 dobj lymphomas,diffuse
R11376 T13376 T13379 aux could,reverted
R11377 T13571 T13570 punct ",",lymphomas
R11378 T13572 T13574 amod primary,lymphoma
R11379 T13573 T13574 compound effusion,lymphoma
R11380 T13377 T13379 neg not,reverted
R11381 T13574 T13570 conj lymphoma,lymphomas
R11382 T13575 T13574 punct ",",lymphoma
R11383 T13576 T13574 cc and,lymphoma
R11384 T13577 T13578 amod marginal,zone
R11385 T13378 T13379 auxpass be,reverted
R11386 T13578 T13574 conj zone,lymphoma
R11387 T13579 T13574 conj lymphoma,lymphoma
R11388 T13580 T13579 punct ",",lymphoma
R11389 T13379 T13379 ROOT reverted,reverted
R11390 T13581 T13579 cc and,lymphoma
R11391 T13582 T13584 compound adult,leukemia
R11392 T13380 T13379 prep in,reverted
R11393 T13583 T13584 compound T-cell,leukemia
R11394 T13584 T13579 conj leukemia,lymphoma
R11395 T13585 T13586 punct (,"11,31,50"
R11396 T13586 T13584 appos "11,31,50",leukemia
R11397 T13381 T13383 amod ICSBP-negative,lines
R11398 T13382 T13383 compound cell,lines
R11399 T13383 T13380 pobj lines,in
R11400 T13587 T13584 appos 52,leukemia
R11401 T13384 T13383 punct (,lines
R11402 T13588 T13584 punct ),leukemia
R11403 T13589 T13554 punct .,found
R11404 T13590 T13591 nsubj This,draws
R11405 T13385 T13383 appos EM-2,lines
R11406 T13591 T13591 ROOT draws,draws
R11407 T13592 T13595 det a,picture
R11408 T13386 T13385 punct ",",EM-2
R11409 T13593 T13594 advmod more,complex
R11410 T13594 T13595 amod complex,picture
R11411 T13387 T13385 conj CML-T1,EM-2
R11412 T13595 T13591 dobj picture,draws
R11413 T13596 T13595 prep of,picture
R11414 T13597 T13598 det the,role
R11415 T13388 T13387 punct ",",CML-T1
R11416 T13598 T13596 pobj role,of
R11417 T13599 T13598 prep of,role
R11418 T13600 T13599 pobj IRF-4,of
R11419 T13601 T13591 punct .,draws
R11420 T13602 T13606 nsubj Down-regulation,promote
R11421 T13603 T13602 prep of,Down-regulation
R11422 T13604 T13603 pobj IRF-4,of
R11423 T13389 T13387 conj K-562,CML-T1
R11424 T13605 T13606 aux may,promote
R11425 T13606 T13606 ROOT promote,promote
R11426 T13607 T13606 dobj leukemogenesis,promote
R11427 T13390 T13389 cc and,K-562
R11428 T13608 T13607 prep in,leukemogenesis
R11429 T13609 T13611 amod myeloid,context
R11430 T13610 T13611 compound cell,context
R11431 T13391 T13389 conj LAMA-84,K-562
R11432 T13611 T13608 pobj context,in
R11433 T13612 T13613 punct (,3
R11434 T13613 T13607 parataxis 3,leukemogenesis
R11435 T13392 T13383 punct ),lines
R11436 T13614 T13613 punct ),3
R11437 T13615 T13613 punct ",",3
R11438 T13616 T13619 nsubjpass which,confirmed
R11439 T13617 T13619 auxpass was,confirmed
R11440 T13653 T13652 advmod together,Taken
R11441 T13618 T13619 advmod recently,confirmed
R11442 T13619 T13613 relcl confirmed,3
R11443 T13620 T13619 prep in,confirmed
R11444 T13621 T13620 pobj IRF-4,in
R11445 T13622 T13631 nmod −,mice
R11446 T13654 T13657 punct ",",suggest
R11447 T13623 T13631 nmod /,mice
R11448 T13624 T13631 nmod −,mice
R11449 T13625 T13631 nmod ICSBP,mice
R11450 T13655 T13656 poss our,data
R11451 T13626 T13631 nmod −,mice
R11452 T13656 T13657 nsubj data,suggest
R11453 T13657 T13657 ROOT suggest,suggest
R11454 T13627 T13631 nmod /,mice
R11455 T13658 T13662 mark that,regulates
R11456 T13628 T13631 nmod −,mice
R11457 T13629 T13631 amod double,mice
R11458 T13659 T13661 amod IRF-4,methylation
R11459 T13660 T13661 compound promoter,methylation
R11460 T13630 T13631 amod knock-out,mice
R11461 T13661 T13662 nsubj methylation,regulates
R11462 T13631 T13619 dobj mice,confirmed
R11463 T13632 T13631 punct (,mice
R11464 T13633 T13631 appos 53,mice
R11465 T13662 T13657 ccomp regulates,suggest
R11466 T13634 T13631 punct ),mice
R11467 T13635 T13619 punct ",",confirmed
R11468 T13636 T13640 mark while,induce
R11469 T13637 T13638 compound IRF-4,up-regulation
R11470 T13638 T13640 nsubj up-regulation,induce
R11471 T13663 T13664 amod IRF-4,expression
R11472 T13639 T13640 aux may,induce
R11473 T13640 T13619 advcl induce,confirmed
R11474 T13641 T13643 det a,advantage
R11475 T13664 T13662 dobj expression,regulates
R11476 T13642 T13643 compound growth,advantage
R11477 T13643 T13640 dobj advantage,induce
R11478 T13644 T13640 prep in,induce
R11479 T13665 T13662 punct ",",regulates
R11480 T13645 T13644 pobj lymphomas,in
R11481 T13646 T13645 cc or,lymphomas
R11482 T13666 T13662 cc and,regulates
R11483 T13647 T13645 conj MM,lymphomas
R11484 T13648 T13647 punct (,MM
R11485 T13649 T13647 appos 48,MM
R11486 T13650 T13647 punct ),MM
R11487 T13667 T13678 mark that,be
R11488 T13651 T13606 punct .,promote
R11489 T13652 T13657 advcl Taken,suggest
R11490 T13668 T13669 amod aberrant,expression
R11491 T13684 T13681 pobj hypermethylation,of
R11492 T13669 T13678 nsubj expression,be
R11493 T13685 T13657 punct .,suggest
R11494 T13670 T13669 prep of,expression
R11495 T13671 T13670 pobj IRF-4,of
R11496 T13672 T13669 prep in,expression
R11497 T13673 T13674 amod certain,types
R11498 T13674 T13672 pobj types,in
R11499 T13675 T13674 prep of,types
R11500 T13676 T13675 pobj leukemia,of
R11501 T13677 T13678 aux may,be
R11502 T13678 T13662 conj be,regulates
R11503 T13679 T13680 det a,consequence
R11504 T13680 T13678 attr consequence,be
R11505 T13681 T13680 prep of,consequence
R11506 T13682 T13684 compound IRF-4,hypermethylation
R11507 T13683 T13684 compound promoter,hypermethylation

UBERON-AE

Id Subject Object Predicate Lexical cue
T11135 3065-3072 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
T11136 3587-3592 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T11137 3594-3598 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T11138 3908-3919 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

GO-BP

Id Subject Object Predicate Lexical cue
T11315 55-70 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T11316 74-90 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressor
T11317 5152-5168 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressor
T11318 199-210 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11319 2246-2257 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11320 2628-2639 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11321 3046-3057 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11322 3193-3204 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11323 3269-3280 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11324 3372-3383 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11325 3491-3502 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11326 4208-4219 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11327 5255-5266 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11328 5496-5507 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11329 6367-6378 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11330 230-265 http://purl.obolibrary.org/obo/GO_0051091 denotes activation of transcription factors
T11331 230-265 http://purl.obolibrary.org/obo/GO_0032793 denotes activation of transcription factors
T11332 230-265 http://purl.obolibrary.org/obo/GO_1901485 denotes activation of transcription factors
T11333 244-257 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T11334 993-1006 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T11335 1760-1775 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T11336 1357-1370 http://purl.obolibrary.org/obo/GO_0070988 denotes demethylation
T11337 1536-1546 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11338 2032-2042 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11339 2806-2816 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11340 6079-6089 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11341 6248-6258 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11342 1847-1862 http://purl.obolibrary.org/obo/GO_0016458 denotes silencing genes
T11343 3908-3925 http://purl.obolibrary.org/obo/GO_0071839 denotes bone marrow cells
T11344 3908-3925 http://purl.obolibrary.org/obo/GO_0071838 denotes bone marrow cells
T11345 6272-6278 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

GO-MF

Id Subject Object Predicate Lexical cue
T13723 230-265 http://purl.obolibrary.org/obo/GO_0033613 denotes activation of transcription factors
T13724 993-1021 http://purl.obolibrary.org/obo/GO_0033613 denotes transcription factor binding
T13725 993-1021 http://purl.obolibrary.org/obo/GO_0008134 denotes transcription factor binding
T13726 993-1021 http://purl.obolibrary.org/obo/GO_0043425 denotes transcription factor binding
T13727 993-1021 http://purl.obolibrary.org/obo/GO_0070491 denotes transcription factor binding
T13728 1014-1021 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13729 1091-1098 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13730 2948-2955 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13731 3106-3113 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13732 4702-4709 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13733 4693-4717 http://purl.obolibrary.org/obo/GO_0005048 denotes sequence binding protein
T13734 4702-4717 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein
T13735 5682-5696 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin

ICD10

Id Subject Object Predicate Lexical cue
T13736 4528-4553 http://purl.bioontology.org/ontology/ICD10/D46 denotes myelodysplastic syndromes
T13737 4528-4553 http://purl.bioontology.org/ontology/ICD10/D46.9 denotes myelodysplastic syndromes
T13738 5585-5601 http://purl.bioontology.org/ontology/ICD10/C90.0 denotes multiple myeloma

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T14312 320-325 Protein denotes IRF-4
T14313 326-336 Gene_expression denotes expression
T14314 313-319 Negative_regulation denotes absent
T14315 455-469 Protein denotes IRF-4 promoter
T14316 505-510 Protein denotes IRF-4
T14317 771-776 Protein denotes IRF-4
T14318 511-521 Gene_expression denotes expression
T14319 777-785 Gene_expression denotes positive
T14320 790-799 Gene_expression denotes -negative
T14321 497-501 Negative_regulation denotes lack
T14322 1170-1191 Protein denotes IRF-4 coding sequence
T14323 1300-1305 Protein denotes IRF-4
T14324 1386-1391 Protein denotes IFN-α
T14325 1306-1316 Gene_expression denotes expression
T14326 1346-1353 Positive_regulation denotes induced
T14327 1550-1555 Protein denotes IRF-4
T14328 1790-1795 Protein denotes IRF-4
T14329 1556-1566 Gene_expression denotes expression
T14330 1531-1546 Negative_regulation denotes down-regulation
T14331 1598-1601 Positive_regulation denotes due
T14332 1911-1926 Protein denotes IRF, IRF-7 (35)
T14333 1972-1977 Protein denotes IRF-4
T14334 1949-1960 Binding denotes interacting
T14335 1949-1960 Binding denotes interacting
T14336 2046-2051 Protein denotes IRF-4
T14337 2052-2062 Gene_expression denotes expression
T14338 2032-2042 Regulation denotes regulation
T14339 2196-2201 Protein denotes IRF-4
T14340 2277-2287 Protein denotes CpG motifs
T14341 2295-2309 Protein denotes IRF-4 promoter
T14342 2202-2212 Gene_expression denotes expression
T14343 2420-2425 Protein denotes IRF-4
T14344 2426-2436 Gene_expression denotes expression
T14345 2409-2416 Negative_regulation denotes absence
T14346 2529-2533 Protein denotes NFκB
T14347 2688-2693 Protein denotes IRF-4
T14348 2694-2702 Gene_expression denotes negative
T14349 2716-2725 Protein denotes CpG sites
T14350 2744-2748 Protein denotes NFκB
T14351 2756-2759 Protein denotes SP1
T14352 2820-2825 Protein denotes IRF-4
T14353 2826-2836 Gene_expression denotes expression
T14354 2806-2816 Regulation denotes regulation
T14355 2861-2874 Protein denotes NFκB elements
T14356 2901-2906 Protein denotes IRF-4
T14357 2920-2925 Protein denotes IRF-4
T14358 2963-2983 Protein denotes transactivator c-Rel
T14359 3009-3023 Protein denotes IRF-4 promoter
T14360 2907-2916 Positive_regulation denotes induction
T14361 2926-2936 Gene_expression denotes expression
T14362 2948-2955 Binding denotes binding
T14363 2893-2897 Regulation denotes role
T14364 2937-2944 Positive_regulation denotes depends
T14365 3084-3088 Protein denotes NFκB
T14366 3121-3133 Protein denotes NFκB protein
T14367 3106-3113 Binding denotes binding
T14368 3097-3105 Negative_regulation denotes inhibits
T14369 3352-3366 Protein denotes IRF-4 promoter
T14370 3427-3432 Protein denotes IRF-4
T14371 3335-3344 Negative_regulation denotes silencing
T14372 3433-3445 Regulation denotes deregulation
T14373 3647-3652 Protein denotes DNMT1
T14374 3629-3643 Positive_regulation denotes overexpression
T14375 3978-3983 Protein denotes DNMT1
T14376 4026-4034 Protein denotes p15INK4b
T14377 3984-3994 Gene_expression denotes expression
T14378 4150-4154 Protein denotes DNMT
T14379 4158-4161 Protein denotes MBP
T14380 4229-4234 Protein denotes IRF-4
T14381 4115-4125 Gene_expression denotes expression
T14382 4115-4125 Gene_expression denotes expression
T14383 4235-4245 Gene_expression denotes expression
T14384 4294-4299 Protein denotes IRF-4
T14385 4430-4435 Protein denotes IRF-4
T14386 4300-4310 Gene_expression denotes expression
T14387 4436-4446 Gene_expression denotes expression
T14388 4422-4426 Negative_regulation denotes loss
T14389 4674-4717 Protein denotes IRF, IFN consensus sequence binding protein
T14390 4719-4724 Protein denotes ICSBP
T14391 4725-4730 Protein denotes IRF-8
T14392 4652-4662 Gene_expression denotes expression
T14393 4652-4662 Gene_expression denotes expression
T14394 4652-4662 Gene_expression denotes expression
T14395 4736-4744 Negative_regulation denotes impaired
T14396 4736-4744 Negative_regulation denotes impaired
T14397 4736-4744 Negative_regulation denotes impaired
T14398 4812-4817 Protein denotes IRF-4
T14399 4836-4839 Protein denotes IRF
T14400 4865-4870 Protein denotes ICSBP
T14401 4964-4969 Protein denotes AzadC
T14402 4987-4992 Protein denotes ICSBP
T14403 5003-5008 Protein denotes ICSBP
T14404 4823-4827 Negative_regulation denotes loss
T14405 4871-4879 Gene_expression denotes negative
T14406 4970-4973 Gene_expression denotes has
T14407 4993-4999 Gene_expression denotes levels
T14408 5009-5017 Gene_expression denotes positive
T14409 5107-5111 Protein denotes IRFs
T14410 5113-5118 Protein denotes IRF-4
T14411 5175-5183 Protein denotes p15INK4b
T14412 5185-5193 Protein denotes p16INK4a
T14413 5197-5200 Protein denotes p53
T14414 5285-5295 Gene_expression denotes expression
T14415 5419-5424 Protein denotes IRF-4
T14416 5481-5514 Protein denotes IRF-4 promoter methylation status
T14417 5682-5708 Protein denotes immunoglobulin heavy-chain
T14418 5710-5713 Protein denotes IgH
T14419 5719-5724 Protein denotes IRF-4
T14420 5769-5774 Protein denotes IRF-4
T14421 5751-5765 Positive_regulation denotes overexpression
T14422 5725-5734 Positive_regulation denotes resulting
T14423 5806-5811 Protein denotes IRF-4
T14424 5812-5822 Gene_expression denotes expression
T14425 6067-6072 Protein denotes IRF-4
T14426 6093-6098 Protein denotes IRF-4
T14427 6187-6201 Protein denotes IRF-4−/− ICSBP
T14428 6239-6244 Protein denotes IRF-4
T14429 6074-6089 Negative_regulation denotes Down-regulation
T14430 6245-6258 Positive_regulation denotes up-regulation
T14431 6352-6366 Protein denotes IRF-4 promoter
T14432 6389-6394 Protein denotes IRF-4
T14433 6439-6444 Protein denotes IRF-4
T14434 6498-6512 Protein denotes IRF-4 promoter
T14435 6395-6405 Gene_expression denotes expression
T14436 6425-6435 Gene_expression denotes expression
T14437 6483-6494 Positive_regulation denotes consequence
T14438 6379-6388 Regulation denotes regulates
R11847 T14312 T14313 themeOf IRF-4,expression
R11849 T14313 T14314 themeOf expression,absent
R11850 T14316 T14318 themeOf IRF-4,expression
R11852 T14317 T14319 themeOf IRF-4,positive
R11853 T14317 T14320 themeOf IRF-4,-negative
R11854 T14318 T14321 themeOf expression,lack
R11856 T14323 T14325 themeOf IRF-4,expression
R11857 T14324 T14326 causeOf IFN-α,induced
R11858 T14325 T14326 themeOf expression,induced
R11860 T14327 T14329 themeOf IRF-4,expression
R11862 T14329 T14330 themeOf expression,down-regulation
R11863 T14330 T14331 themeOf down-regulation,due
R11864 T14370 T14372 themeOf IRF-4,deregulation
R11865 T14332 T14335 themeOf "IRF, IRF-7 (35)",interacting
R11866 T14333 T14334 themeOf IRF-4,interacting
R11867 T14333 T14335 themeOf IRF-4,interacting
R11868 T14336 T14337 themeOf IRF-4,expression
R11869 T14337 T14338 themeOf expression,regulation
R11870 T14339 T14342 themeOf IRF-4,expression
R11871 T14373 T14374 themeOf DNMT1,overexpression
R11872 T14343 T14344 themeOf IRF-4,expression
R11873 T14344 T14345 themeOf expression,absence
R11874 T14375 T14377 themeOf DNMT1,expression
R11875 T14347 T14348 themeOf IRF-4,negative
R11876 T14378 T14381 themeOf DNMT,expression
R11877 T14352 T14353 themeOf IRF-4,expression
R11878 T14353 T14354 themeOf expression,regulation
R11879 T14379 T14382 themeOf MBP,expression
R11880 T14380 T14383 themeOf IRF-4,expression
R11881 T14355 T14363 causeOf NFκB elements,role
R11882 T14356 T14360 themeOf IRF-4,induction
R11883 T14357 T14361 themeOf IRF-4,expression
R11884 T14358 T14362 themeOf transactivator c-Rel,binding
R11885 T14384 T14386 themeOf IRF-4,expression
R11886 T14360 T14363 themeOf induction,role
R11887 T14361 T14364 themeOf expression,depends
R11888 T14362 T14364 causeOf binding,depends
R11889 T14385 T14387 themeOf IRF-4,expression
R11890 T14366 T14367 themeOf NFκB protein,binding
R11891 T14367 T14368 themeOf binding,inhibits
R11892 T14387 T14388 themeOf expression,loss
R11893 T14369 T14371 themeOf IRF-4 promoter,silencing
R11894 T14389 T14392 themeOf "IRF, IFN consensus sequence binding protein",expression
R11895 T14390 T14393 themeOf ICSBP,expression
R11896 T14391 T14394 themeOf IRF-8,expression
R11897 T14392 T14395 themeOf expression,impaired
R11898 T14393 T14396 themeOf expression,impaired
R11899 T14394 T14397 themeOf expression,impaired
R11900 T14399 T14404 themeOf IRF,loss
R11901 T14400 T14405 themeOf ICSBP,negative
R11902 T14401 T14406 themeOf AzadC,has
R11903 T14402 T14407 themeOf ICSBP,levels
R11904 T14403 T14408 themeOf ICSBP,positive
R11905 T14410 T14414 themeOf IRF-4,expression
R11911 T14420 T14421 themeOf IRF-4,overexpression
R11916 T14421 T14422 themeOf overexpression,resulting
R11919 T14423 T14424 themeOf IRF-4,expression
R11922 T14426 T14429 themeOf IRF-4,Down-regulation
R11924 T14428 T14430 themeOf IRF-4,up-regulation
R11925 T14432 T14435 themeOf IRF-4,expression
R11927 T14433 T14436 themeOf IRF-4,expression
R11928 T14435 T14438 themeOf expression,regulates
R11931 T14436 T14437 themeOf expression,consequence

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T11161 1084-1104 Entity denotes primer binding sites
T11162 1170-1175 Protein denotes IRF-4
T11163 1300-1305 Protein denotes IRF-4
T11164 1306-1316 Gene_expression denotes expression
T11165 1346-1353 Positive_regulation denotes induced
T11166 1386-1391 Protein denotes IFN-α
T11167 1531-1546 Negative_regulation denotes down-regulation
T11168 1550-1555 Protein denotes IRF-4
T11169 1556-1566 Gene_expression denotes expression
T11170 1598-1601 Positive_regulation denotes due true
T11171 1674-1687 Gene_expression denotes re-expression
T11172 1727-1733 Positive_regulation denotes result true
T11173 1790-1795 Protein denotes IRF-4
T11174 1916-1921 Protein denotes IRF-7
T11175 1935-1939 Protein denotes PU.1
T11176 1949-1960 Binding denotes interacting
T11177 1972-1977 Protein denotes IRF-4
T11178 2032-2042 Regulation denotes regulation
T11179 2046-2051 Protein denotes IRF-4
T11180 2052-2062 Gene_expression denotes expression
T11181 2196-2201 Protein denotes IRF-4
T11182 2202-2212 Gene_expression denotes expression
T11183 2295-2300 Protein denotes IRF-4
T11184 2393-2400 Positive_regulation denotes account true
T11185 2409-2416 Negative_regulation denotes absence
T11186 2420-2425 Protein denotes IRF-4
T11187 2426-2436 Gene_expression denotes expression
T11188 2650-2655 Protein denotes IRF-4
T11189 2656-2664 Gene_expression denotes positive
T11190 2688-2693 Protein denotes IRF-4
T11191 2798-2802 Regulation denotes role true
T11192 2806-2816 Regulation denotes regulation
T11193 2820-2825 Protein denotes IRF-4
T11194 2826-2836 Gene_expression denotes expression
T11195 2861-2874 Entity denotes NFκB elements
T11196 2883-2897 Regulation denotes important role
T11197 2901-2906 Protein denotes IRF-4
T11198 2907-2916 Positive_regulation denotes induction
T11199 2920-2925 Protein denotes IRF-4
T11200 2926-2936 Gene_expression denotes expression
T11201 2937-2944 Positive_regulation denotes depends
T11202 2948-2955 Binding denotes binding
T11203 2978-2983 Protein denotes c-Rel
T11204 3009-3014 Protein denotes IRF-4
T11205 3073-3076 Entity denotes CpG
T11206 3084-3096 Entity denotes NFκB element
T11207 3097-3105 Negative_regulation denotes inhibits
T11208 3106-3113 Binding denotes binding
T11209 3220-3225 Protein denotes IRF-4
T11210 3226-3234 Gene_expression denotes positive
T11211 3240-3248 Gene_expression denotes negative true
T11212 3335-3344 Negative_regulation denotes silencing
T11213 3352-3357 Protein denotes IRF-4
T11214 3358-3366 Entity denotes promoter
T11215 3427-3432 Protein denotes IRF-4
T11216 3433-3445 Regulation denotes deregulation true
T11217 3629-3643 Positive_regulation denotes overexpression
T11218 3647-3652 Protein denotes DNMT1
T11219 3978-3983 Protein denotes DNMT1
T11220 3984-3994 Gene_expression denotes expression
T11221 4026-4034 Protein denotes p15INK4b
T11222 4229-4234 Protein denotes IRF-4
T11223 4235-4245 Gene_expression denotes expression
T11224 4294-4299 Protein denotes IRF-4
T11225 4300-4310 Gene_expression denotes expression
T11226 4422-4426 Negative_regulation denotes loss
T11227 4430-4435 Protein denotes IRF-4
T11228 4436-4446 Gene_expression denotes expression
T11229 4652-4662 Gene_expression denotes expression
T11230 4679-4717 Protein denotes IFN consensus sequence binding protein
T11231 4719-4724 Protein denotes ICSBP
T11232 4725-4730 Protein denotes IRF-8
T11233 4736-4744 Negative_regulation denotes impaired
T11234 4812-4817 Protein denotes IRF-4
T11235 4823-4827 Negative_regulation denotes loss
T11236 4853-4861 Negative_regulation denotes reverted true
T11237 4865-4870 Protein denotes ICSBP
T11238 4871-4879 Gene_expression denotes negative true
T11239 4977-4983 Regulation denotes effect true
T11240 4987-4992 Protein denotes ICSBP
T11241 4993-4999 Gene_expression denotes levels
T11242 5003-5008 Protein denotes ICSBP
T11243 5009-5017 Gene_expression denotes positive
T11244 5113-5118 Protein denotes IRF-4
T11245 5175-5183 Protein denotes p15INK4b
T11246 5185-5193 Protein denotes p16INK4a
T11247 5197-5200 Protein denotes p53
T11248 5285-5295 Gene_expression denotes expression
T11249 5296-5303 Regulation denotes changes
T11250 5419-5424 Protein denotes IRF-4
T11251 5481-5486 Protein denotes IRF-4
T11252 5529-5534 Protein denotes IRF-4
T11253 5682-5708 Protein denotes immunoglobulin heavy-chain
T11254 5710-5713 Protein denotes IgH
T11255 5719-5724 Protein denotes IRF-4
T11256 5725-5734 Positive_regulation denotes resulting
T11257 5751-5765 Positive_regulation denotes overexpression
T11258 5769-5774 Protein denotes IRF-4
T11259 5806-5811 Protein denotes IRF-4
T11260 5812-5822 Gene_expression denotes expression
T11261 6067-6072 Protein denotes IRF-4
T11262 6074-6089 Negative_regulation denotes Down-regulation
T11263 6093-6098 Protein denotes IRF-4
T11264 6187-6192 Protein denotes IRF-4
T11265 6196-6201 Protein denotes ICSBP
T11266 6212-6221 Gene_expression denotes knock-out true
T11267 6212-6221 Gene_expression denotes knock-out true
T11268 6239-6244 Protein denotes IRF-4
T11269 6245-6258 Positive_regulation denotes up-regulation
T11270 6352-6357 Protein denotes IRF-4
T11271 6379-6388 Regulation denotes regulates true
T11272 6389-6394 Protein denotes IRF-4
T11273 6395-6405 Gene_expression denotes expression
T11274 6425-6435 Gene_expression denotes expression
T11275 6439-6444 Protein denotes IRF-4
T11276 6483-6494 Positive_regulation denotes consequence true
T11277 6498-6503 Protein denotes IRF-4
T11139 313-319 Negative_regulation denotes absent
T11140 320-325 Protein denotes IRF-4
T11141 326-336 Gene_expression denotes expression
T11142 455-460 Protein denotes IRF-4
T11143 497-501 Negative_regulation denotes lack
T11144 505-510 Protein denotes IRF-4
T11145 511-521 Gene_expression denotes expression
T11146 682-693 Positive_regulation denotes responsible true
T11147 698-704 Negative_regulation denotes absent
T11148 705-710 Protein denotes IRF-4
T11149 711-721 Gene_expression denotes expression
T11150 771-776 Protein denotes IRF-4
T11151 777-785 Gene_expression denotes positive
T11152 791-799 Gene_expression denotes negative true
T11153 869-874 Protein denotes IRF-4
T11154 875-883 Gene_expression denotes negative true
T11155 888-896 Gene_expression denotes positive
T11156 967-973 Regulation denotes change true
T11157 993-1027 Entity denotes transcription factor binding sites
T11158 1052-1058 Regulation denotes affect true
T11159 1052-1058 Regulation denotes affect true
T11160 1063-1080 Entity denotes restriction sites
R9141 T11145 T11143 themeOf expression,lack
R9143 T11148 T11149 themeOf IRF-4,expression
R9144 T11149 T11147 themeOf expression,absent
R9145 T11150 T11151 themeOf IRF-4,positive
R9146 T11150 T11152 themeOf IRF-4,negative
R9147 T11153 T11154 themeOf IRF-4,negative
R9148 T11153 T11155 themeOf IRF-4,positive
R9149 T11157 T11156 themeOf transcription factor binding sites,change
R9150 T11157 T11148 partOf transcription factor binding sites,IRF-4
R9151 T11160 T11158 themeOf restriction sites,affect
R9152 T11160 T11148 partOf restriction sites,IRF-4
R9153 T11161 T11159 themeOf primer binding sites,affect
R9154 T11161 T11148 partOf primer binding sites,IRF-4
R9155 T11163 T11164 themeOf IRF-4,expression
R9156 T11164 T11165 themeOf expression,induced
R9157 T11166 T11165 causeOf IFN-α,induced
R9158 T11167 T11170 themeOf down-regulation,due
R9159 T11168 T11169 themeOf IRF-4,expression
R9160 T11168 T11171 themeOf IRF-4,re-expression
R9161 T11169 T11167 themeOf expression,down-regulation
R9162 T11171 T11172 themeOf re-expression,result
R9163 T11175 T11176 themeOf PU.1,interacting
R9164 T11177 T11176 themeOf IRF-4,interacting
R9165 T11179 T11180 themeOf IRF-4,expression
R9166 T11180 T11178 themeOf expression,regulation
R9167 T11181 T11182 themeOf IRF-4,expression
R9168 T11185 T11184 themeOf absence,account
R9169 T11186 T11187 themeOf IRF-4,expression
R9170 T11187 T11185 themeOf expression,absence
R9171 T11188 T11189 themeOf IRF-4,positive
R9172 T11192 T11191 themeOf regulation,role
R9173 T11193 T11194 themeOf IRF-4,expression
R9174 T11194 T11192 themeOf expression,regulation
R9175 T11195 T11196 causeOf NFκB elements,important role
R9176 T11195 T11204 partOf NFκB elements,IRF-4
R9177 T11195 T11202 themeOf NFκB elements,binding
R9178 T11197 T11198 themeOf IRF-4,induction
R9179 T11198 T11196 themeOf induction,important role
R9180 T11199 T11200 themeOf IRF-4,expression
R9181 T11200 T11201 themeOf expression,depends
R9182 T11202 T11201 causeOf binding,depends
R9183 T11203 T11202 themeOf c-Rel,binding
R9184 T11205 T11207 causeOf CpG,inhibits
R9185 T11205 T11204 partOf CpG,IRF-4
R9186 T11206 T11208 themeOf NFκB element,binding
R9187 T11206 T11204 partOf NFκB element,IRF-4
R9188 T11208 T11207 themeOf binding,inhibits
R9189 T11209 T11210 themeOf IRF-4,positive
R9190 T11209 T11211 themeOf IRF-4,negative
R9191 T11214 T11212 themeOf promoter,silencing
R9192 T11214 T11213 partOf promoter,IRF-4
R9193 T11215 T11216 themeOf IRF-4,deregulation
R9194 T11218 T11217 themeOf DNMT1,overexpression
R9195 T11219 T11220 themeOf DNMT1,expression
R9196 T11222 T11223 themeOf IRF-4,expression
R9197 T11224 T11225 themeOf IRF-4,expression
R9198 T11227 T11228 themeOf IRF-4,expression
R9199 T11228 T11226 themeOf expression,loss
R9200 T11229 T11233 themeOf expression,impaired
R9201 T11230 T11229 themeOf IFN consensus sequence binding protein,expression
R9202 T11230 T11235 themeOf IFN consensus sequence binding protein,loss
R9203 T11231 T11230 equivalentTo ICSBP,IFN consensus sequence binding protein
R9204 T11232 T11230 equivalentTo IRF-8,IFN consensus sequence binding protein
R9205 T11235 T11236 themeOf loss,reverted
R9206 T11237 T11238 themeOf ICSBP,negative
R9207 T11240 T11241 themeOf ICSBP,levels
R9208 T11241 T11239 themeOf levels,effect
R9209 T11242 T11243 themeOf ICSBP,positive
R9210 T11244 T11248 themeOf IRF-4,expression
R9211 T11248 T11249 themeOf expression,changes
R9212 T11254 T11253 equivalentTo IgH,immunoglobulin heavy-chain
R9213 T11257 T11256 themeOf overexpression,resulting
R9214 T11258 T11257 themeOf IRF-4,overexpression
R9215 T11259 T11260 themeOf IRF-4,expression
R9216 T11263 T11262 themeOf IRF-4,Down-regulation
R9217 T11264 T11267 themeOf IRF-4,knock-out
R9218 T11265 T11266 themeOf ICSBP,knock-out
R9219 T11268 T11269 themeOf IRF-4,up-regulation
R9220 T11272 T11273 themeOf IRF-4,expression
R9221 T11273 T11271 themeOf expression,regulates
R9222 T11274 T11276 themeOf expression,consequence
R9223 T11275 T11274 themeOf IRF-4,expression
R9138 T11140 T11141 themeOf IRF-4,expression
R9139 T11141 T11139 themeOf expression,absent
R9140 T11144 T11145 themeOf IRF-4,expression
R9142 T11147 T11146 themeOf absent,responsible

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T12446 320-325 Q15306 denotes IRF-4
T12447 455-460 Q15306 denotes IRF-4
T12448 505-510 Q15306 denotes IRF-4
T12449 705-710 Q15306 denotes IRF-4
T12450 771-776 Q15306 denotes IRF-4
T12451 869-874 Q15306 denotes IRF-4
T12452 1170-1175 Q15306 denotes IRF-4
T12453 1300-1305 Q15306 denotes IRF-4
T12454 1386-1391 P01562 denotes IFN-α
T12455 1550-1555 Q15306 denotes IRF-4
T12456 1790-1795 Q15306 denotes IRF-4
T12457 1916-1921 Q92985 denotes IRF-7
T12458 1935-1939 P17947 denotes PU.1
T12459 1972-1977 Q15306 denotes IRF-4
T12460 2046-2051 Q15306 denotes IRF-4
T12461 2196-2201 Q15306 denotes IRF-4
T12462 2295-2300 Q15306 denotes IRF-4
T12463 2420-2425 Q15306 denotes IRF-4
T12464 2650-2655 Q15306 denotes IRF-4
T12465 2688-2693 Q15306 denotes IRF-4
T12466 2756-2759 P08047 denotes SP1
T12467 2820-2825 Q15306 denotes IRF-4
T12468 2901-2906 Q15306 denotes IRF-4
T12469 2920-2925 Q15306 denotes IRF-4
T12470 2978-2983 Q04864 denotes c-Rel
T12471 2980-2983 Q04864 denotes Rel
T12472 3009-3014 Q15306 denotes IRF-4
T12473 3220-3225 Q15306 denotes IRF-4
T12474 3352-3357 Q15306 denotes IRF-4
T12475 3427-3432 Q15306 denotes IRF-4
T12476 3545-3550 P26358 denotes DNMTs
T12477 3647-3652 P26358 denotes DNMT1
T12478 3668-3672 P26358 denotes DNMT
T12479 3811-3816 P26358 denotes DNMTs
T12480 3878-3883 P26358 denotes DNMTs
T12481 3978-3983 P26358 denotes DNMT1
T12482 4026-4034 P42772 denotes p15INK4b
T12483 4150-4154 P26358 denotes DNMT
T12484 4229-4234 Q15306 denotes IRF-4
T12485 4294-4299 Q15306 denotes IRF-4
T12486 4430-4435 Q15306 denotes IRF-4
T12487 4679-4717 Q02556 denotes IFN consensus sequence binding protein
T12488 4719-4724 Q02556 denotes ICSBP
T12489 4725-4730 Q02556 denotes IRF-8
T12490 4812-4817 Q15306 denotes IRF-4
T12491 4865-4870 Q02556 denotes ICSBP
T12492 4987-4992 Q02556 denotes ICSBP
T12493 5003-5008 Q02556 denotes ICSBP
T12494 5113-5118 Q15306 denotes IRF-4
T12495 5175-5183 P42772 denotes p15INK4b
T12496 5185-5193 P42771 denotes p16INK4a
T12497 5197-5200 P04637 denotes p53
T12498 5419-5424 Q15306 denotes IRF-4
T12499 5481-5486 Q15306 denotes IRF-4
T12500 5529-5534 Q15306 denotes IRF-4
T12501 5682-5708 P01860 denotes immunoglobulin heavy-chain
T12502 5682-5708 P01871 denotes immunoglobulin heavy-chain
T12503 5682-5708 P01876 denotes immunoglobulin heavy-chain
T12504 5682-5708 P01877 denotes immunoglobulin heavy-chain
T12505 5682-5708 P01859 denotes immunoglobulin heavy-chain
T12506 5682-5708 P01857 denotes immunoglobulin heavy-chain
T12507 5682-5708 P01854 denotes immunoglobulin heavy-chain
T12508 5682-5708 P01861 denotes immunoglobulin heavy-chain
T12509 5682-5708 P01880 denotes immunoglobulin heavy-chain
T12510 5710-5713 P01876 denotes IgH
T12511 5710-5713 P01854 denotes IgH
T12512 5710-5713 P01857 denotes IgH
T12513 5710-5713 P01859 denotes IgH
T12514 5710-5713 P01860 denotes IgH
T12515 5710-5713 P01861 denotes IgH
T12516 5710-5713 P01871 denotes IgH
T12517 5710-5713 P01877 denotes IgH
T12518 5710-5713 P01880 denotes IgH
T12519 5719-5724 Q15306 denotes IRF-4
T12520 5769-5774 Q15306 denotes IRF-4
T12521 5806-5811 Q15306 denotes IRF-4
T12522 6067-6072 Q15306 denotes IRF-4
T12523 6093-6098 Q15306 denotes IRF-4
T12524 6187-6192 Q15306 denotes IRF-4
T12525 6196-6201 Q02556 denotes ICSBP
T12526 6239-6244 Q15306 denotes IRF-4
T12527 6352-6357 Q15306 denotes IRF-4
T12528 6389-6394 Q15306 denotes IRF-4
T12529 6439-6444 Q15306 denotes IRF-4
T12530 6498-6503 Q15306 denotes IRF-4

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T11012 320-325 Protein denotes IRF-4
T11013 326-336 Gene_expression denotes expression
T11014 455-460 Protein denotes IRF-4
T11015 497-501 Negative_regulation denotes lack
T11016 505-510 Protein denotes IRF-4 true
T11017 511-521 Gene_expression denotes expression
T11018 682-693 Regulation denotes responsible
T11019 705-710 Protein denotes IRF-4
T11020 711-721 Gene_expression denotes expression true
T11021 771-776 Protein denotes IRF-4 true
T11022 777-785 Gene_expression denotes positive
T11023 791-799 Gene_expression denotes negative true
T11024 869-874 Protein denotes IRF-4 true
T11025 875-883 Gene_expression denotes negative true
T11026 888-896 Gene_expression denotes positive
T11027 1007-1027 Entity denotes factor binding sites
T11028 1091-1104 Entity denotes binding sites
T11029 1170-1175 Protein denotes IRF-4
T11030 1300-1305 Protein denotes IRF-4 true
T11031 1306-1316 Gene_expression denotes expression
T11032 1346-1353 Positive_regulation denotes induced true
T11033 1386-1391 Protein denotes IFN-α
T11034 1531-1546 Negative_regulation denotes down-regulation
T11035 1550-1555 Protein denotes IRF-4
T11036 1556-1566 Gene_expression denotes expression
T11037 1598-1601 Positive_regulation denotes due true
T11038 1676-1677 Gene_expression denotes -
T11039 1677-1687 Gene_expression denotes expression
T11040 1760-1775 Transcription denotes transcriptional
T11041 1790-1795 Protein denotes IRF-4 true
T11042 1916-1921 Protein denotes IRF-7
T11043 1935-1939 Protein denotes PU.1
T11044 1949-1960 Binding denotes interacting
T11045 1972-1977 Protein denotes IRF-4
T11046 2032-2042 Regulation denotes regulation
T11047 2046-2051 Protein denotes IRF-4
T11048 2052-2062 Gene_expression denotes expression
T11049 2196-2201 Protein denotes IRF-4
T11050 2202-2212 Gene_expression denotes expression
T11051 2295-2300 Protein denotes IRF-4
T11052 2409-2416 Negative_regulation denotes absence true
T11053 2420-2425 Protein denotes IRF-4
T11054 2426-2436 Gene_expression denotes expression true
T11055 2650-2655 Protein denotes IRF-4
T11056 2656-2664 Gene_expression denotes positive
T11057 2688-2693 Protein denotes IRF-4
T11058 2694-2702 Gene_expression denotes negative
T11059 2798-2802 Regulation denotes role
T11060 2806-2816 Regulation denotes regulation
T11061 2820-2825 Protein denotes IRF-4
T11062 2826-2836 Gene_expression denotes expression
T11063 2893-2897 Regulation denotes role
T11064 2901-2906 Protein denotes IRF-4 true
T11065 2907-2916 Positive_regulation denotes induction true
T11066 2920-2925 Protein denotes IRF-4 true
T11067 2926-2936 Gene_expression denotes expression
T11068 2948-2955 Binding denotes binding
T11069 2978-2983 Protein denotes c-Rel
T11070 3009-3014 Protein denotes IRF-4
T11071 3106-3113 Binding denotes binding
T11072 3220-3225 Protein denotes IRF-4
T11073 3226-3234 Gene_expression denotes positive
T11074 3240-3248 Gene_expression denotes negative
T11075 3335-3344 Negative_regulation denotes silencing true
T11076 3352-3357 Protein denotes IRF-4 true
T11077 3427-3432 Protein denotes IRF-4
T11078 3433-3445 Regulation denotes deregulation true
T11079 3629-3643 Positive_regulation denotes overexpression
T11080 3647-3652 Protein denotes DNMT1
T11081 3978-3983 Protein denotes DNMT1 true
T11082 3984-3994 Gene_expression denotes expression
T11083 4026-4034 Protein denotes p15INK4b
T11084 4229-4234 Protein denotes IRF-4
T11085 4235-4245 Gene_expression denotes expression
T11086 4294-4299 Protein denotes IRF-4
T11087 4300-4310 Gene_expression denotes expression
T11088 4314-4322 Negative_regulation denotes silenced
T11089 4422-4426 Negative_regulation denotes loss
T11090 4430-4435 Protein denotes IRF-4
T11091 4436-4446 Gene_expression denotes expression
T11092 4652-4662 Gene_expression denotes expression
T11093 4679-4717 Protein denotes IFN consensus sequence binding protein
T11094 4719-4724 Protein denotes ICSBP
T11095 4725-4730 Protein denotes IRF-8
T11096 4736-4744 Negative_regulation denotes impaired
T11097 4812-4817 Protein denotes IRF-4
T11098 4823-4827 Negative_regulation denotes loss
T11099 4853-4861 Negative_regulation denotes reverted
T11100 4865-4870 Protein denotes ICSBP
T11101 4871-4879 Gene_expression denotes negative
T11102 4977-4983 Regulation denotes effect
T11103 4987-4992 Protein denotes ICSBP
T11104 5003-5008 Protein denotes ICSBP
T11105 5009-5017 Gene_expression denotes positive
T11106 5113-5118 Protein denotes IRF-4
T11107 5175-5183 Protein denotes p15INK4b
T11108 5185-5193 Protein denotes p16INK4a
T11109 5197-5200 Protein denotes p53
T11110 5419-5424 Protein denotes IRF-4
T11111 5481-5486 Protein denotes IRF-4
T11112 5529-5534 Protein denotes IRF-4
T11113 5682-5708 Protein denotes immunoglobulin heavy-chain
T11114 5710-5713 Protein denotes IgH
T11115 5719-5724 Protein denotes IRF-4
T11116 5725-5734 Positive_regulation denotes resulting
T11117 5751-5765 Positive_regulation denotes overexpression
T11118 5769-5774 Protein denotes IRF-4
T11119 5806-5811 Protein denotes IRF-4
T11120 5812-5822 Gene_expression denotes expression
T11121 6067-6072 Protein denotes IRF-4
T11122 6074-6089 Negative_regulation denotes Down-regulation
T11123 6093-6098 Protein denotes IRF-4
T11124 6187-6192 Protein denotes IRF-4
T11125 6196-6201 Protein denotes ICSBP
T11126 6239-6244 Protein denotes IRF-4
T11127 6245-6258 Positive_regulation denotes up-regulation
T11128 6352-6357 Protein denotes IRF-4
T11129 6379-6388 Regulation denotes regulates
T11130 6389-6394 Protein denotes IRF-4
T11131 6395-6405 Gene_expression denotes expression
T11132 6425-6435 Gene_expression denotes expression
T11133 6439-6444 Protein denotes IRF-4
T11134 6498-6503 Protein denotes IRF-4
R9075 T11012 T11013 themeOf IRF-4,expression
R9076 T11015 T11018 causeOf lack,responsible
R9077 T11016 T11017 themeOf IRF-4,expression
R9078 T11017 T11015 themeOf expression,lack
R9079 T11019 T11020 themeOf IRF-4,expression
R9080 T11020 T11018 themeOf expression,responsible
R9081 T11021 T11023 themeOf IRF-4,negative
R9082 T11021 T11022 themeOf IRF-4,positive
R9083 T11024 T11025 themeOf IRF-4,negative
R9084 T11024 T11026 themeOf IRF-4,positive
R9085 T11030 T11031 themeOf IRF-4,expression
R9086 T11031 T11032 themeOf expression,induced
R9087 T11033 T11032 causeOf IFN-α,induced
R9088 T11034 T11037 themeOf down-regulation,due
R9089 T11035 T11036 themeOf IRF-4,expression
R9090 T11036 T11034 themeOf expression,down-regulation
R9091 T11036 T11037 themeOf expression,due
R9092 T11041 T11040 themeOf IRF-4,transcriptional
R9093 T11042 T11044 themeOf IRF-7,interacting
R9094 T11043 T11044 themeOf PU.1,interacting
R9095 T11045 T11044 themeOf IRF-4,interacting
R9096 T11047 T11048 themeOf IRF-4,expression
R9097 T11048 T11046 themeOf expression,regulation
R9098 T11049 T11050 themeOf IRF-4,expression
R9099 T11053 T11054 themeOf IRF-4,expression
R9100 T11054 T11052 themeOf expression,absence
R9101 T11055 T11056 themeOf IRF-4,positive
R9102 T11057 T11058 themeOf IRF-4,negative
R9103 T11061 T11062 themeOf IRF-4,expression
R9104 T11062 T11060 themeOf expression,regulation
R9105 T11064 T11065 themeOf IRF-4,induction
R9106 T11065 T11063 themeOf induction,role
R9107 T11066 T11067 themeOf IRF-4,expression
R9108 T11069 T11068 themeOf c-Rel,binding
R9109 T11072 T11073 themeOf IRF-4,positive
R9110 T11072 T11074 themeOf IRF-4,negative
R9111 T11077 T11078 themeOf IRF-4,deregulation
R9112 T11080 T11079 themeOf DNMT1,overexpression
R9113 T11081 T11082 themeOf DNMT1,expression
R9114 T11084 T11085 themeOf IRF-4,expression
R9115 T11086 T11087 themeOf IRF-4,expression
R9116 T11087 T11088 themeOf expression,silenced
R9117 T11090 T11091 themeOf IRF-4,expression
R9118 T11091 T11089 themeOf expression,loss
R9119 T11092 T11096 themeOf expression,impaired
R9120 T11093 T11092 themeOf IFN consensus sequence binding protein,expression
R9121 T11094 T11093 equivalentTo ICSBP,IFN consensus sequence binding protein
R9122 T11095 T11093 equivalentTo IRF-8,IFN consensus sequence binding protein
R9123 T11098 T11099 themeOf loss,reverted
R9124 T11100 T11101 themeOf ICSBP,negative
R9125 T11101 T11099 causeOf negative,reverted
R9126 T11104 T11105 themeOf ICSBP,positive
R9127 T11114 T11113 equivalentTo IgH,immunoglobulin heavy-chain
R9128 T11117 T11116 themeOf overexpression,resulting
R9129 T11118 T11117 themeOf IRF-4,overexpression
R9130 T11119 T11120 themeOf IRF-4,expression
R9131 T11123 T11122 themeOf IRF-4,Down-regulation
R9132 T11124 T11127 themeOf IRF-4,up-regulation
R9133 T11125 T11127 themeOf ICSBP,up-regulation
R9134 T11126 T11127 themeOf IRF-4,up-regulation
R9135 T11130 T11131 themeOf IRF-4,expression
R9136 T11131 T11129 themeOf expression,regulates
R9137 T11133 T11132 themeOf IRF-4,expression