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PMC:1310901 / 156-1797 JSONTXT

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bionlp-st-ge-2016-reference-eval

Id Subject Object Predicate Lexical cue
T871 13-16 Protein denotes bcr
T872 17-20 Protein denotes abl
T873 160-172 Regulation denotes deregulation
T874 222-252 Protein denotes interferon regulatory factor 4
T875 254-259 Protein denotes IRF-4
T876 513-518 Protein denotes IRF-4
T877 575-585 Regulation denotes regulation
T878 589-594 Protein denotes IRF-4
T879 595-605 Gene_expression denotes expression
T880 713-720 Regulation denotes altered
T881 721-726 Protein denotes IRF-4
T882 727-737 Gene_expression denotes expression
T883 766-771 Protein denotes IRF-4
T884 827-836 Regulation denotes influence
T885 837-842 Protein denotes IRF-4
T886 843-856 Transcription denotes transcription
T887 878-883 Protein denotes IRF-4
T888 884-892 Gene_expression denotes negative
T889 989-997 Positive_regulation denotes resulted
T890 1037-1045 Positive_regulation denotes increase
T891 1049-1054 Protein denotes IRF-4
T892 1194-1199 Protein denotes IRF-4
T893 1200-1208 Gene_expression denotes negative
T894 1220-1225 Protein denotes IRF-4
T895 1226-1234 Gene_expression denotes positive
T896 1311-1316 Protein denotes IRF-4
T897 1317-1332 Negative_regulation denotes down-regulation
T898 1542-1547 Protein denotes IRF-4
T899 1596-1610 Negative_regulation denotes down-regulated
T900 1611-1616 Protein denotes IRF-4
T901 1617-1627 Gene_expression denotes expression
R632 T874 T873 themeOf interferon regulatory factor 4,deregulation
R633 T875 T874 equivalentTo IRF-4,interferon regulatory factor 4
R634 T878 T879 themeOf IRF-4,expression
R635 T879 T877 themeOf expression,regulation
R636 T881 T882 themeOf IRF-4,expression
R637 T882 T880 themeOf expression,altered
R638 T885 T886 themeOf IRF-4,transcription
R639 T886 T884 themeOf transcription,influence
R640 T887 T888 themeOf IRF-4,negative
R641 T890 T889 themeOf increase,resulted
R642 T891 T890 themeOf IRF-4,increase
R643 T892 T893 themeOf IRF-4,negative
R644 T894 T895 themeOf IRF-4,positive
R645 T896 T897 themeOf IRF-4,down-regulation
R646 T900 T901 themeOf IRF-4,expression
R647 T901 T899 themeOf expression,down-regulated

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T811 254-259 Protein denotes IRF-4
T812 513-518 Protein denotes IRF-4
T813 575-585 Regulation denotes regulation true
T814 589-594 Protein denotes IRF-4
T815 595-605 Gene_expression denotes expression
T816 713-720 Regulation denotes altered
T817 721-726 Protein denotes IRF-4
T818 727-737 Gene_expression denotes expression
T819 766-771 Protein denotes IRF-4
T820 827-836 Regulation denotes influence
T821 837-842 Protein denotes IRF-4
T822 843-856 Transcription denotes transcription
T823 878-883 Protein denotes IRF-4
T824 884-892 Gene_expression denotes negative true
T825 989-997 Positive_regulation denotes resulted
T826 1037-1045 Positive_regulation denotes increase
T827 1049-1054 Protein denotes IRF-4
T828 1194-1199 Protein denotes IRF-4
T829 1200-1208 Gene_expression denotes negative true
T830 1220-1225 Protein denotes IRF-4
T831 1226-1234 Gene_expression denotes positive
T832 1311-1316 Protein denotes IRF-4
T833 1317-1332 Negative_regulation denotes down-regulation
T834 1542-1547 Protein denotes IRF-4
T835 1596-1610 Negative_regulation denotes down-regulated true
T836 1611-1616 Protein denotes IRF-4
T837 1617-1627 Gene_expression denotes expression
T807 13-16 Protein denotes bcr
T808 17-20 Protein denotes abl
T809 160-172 Regulation denotes deregulation true
T810 222-252 Protein denotes interferon regulatory factor 4
R600 T811 T810 equivalentTo IRF-4,interferon regulatory factor 4
R601 T814 T815 themeOf IRF-4,expression
R602 T815 T813 themeOf expression,regulation
R603 T817 T818 themeOf IRF-4,expression
R604 T818 T816 themeOf expression,altered
R605 T821 T822 themeOf IRF-4,transcription
R606 T822 T820 themeOf transcription,influence
R607 T823 T824 themeOf IRF-4,negative
R608 T826 T825 themeOf increase,resulted
R609 T827 T826 themeOf IRF-4,increase
R610 T828 T829 themeOf IRF-4,negative
R611 T830 T831 themeOf IRF-4,positive
R612 T832 T833 themeOf IRF-4,down-regulation
R613 T836 T837 themeOf IRF-4,expression
R614 T837 T835 themeOf expression,down-regulated
R694 T810 T809 themeOf interferon regulatory factor 4,deregulation

GO-CC

Id Subject Object Predicate Lexical cue
T701 1235-1240 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T699 618-623 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T700 755-760 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T106 0-308 Sentence denotes Although the bcr-abl translocation has been shown to be the causative genetic aberration in chronic myeloid leukemia (CML), there is mounting evidence that the deregulation of other genes, such as the transcription factor interferon regulatory factor 4 (IRF-4), is also implicated in the pathogenesis of CML.
T107 309-477 Sentence denotes Promoter methylation of CpG target sites or direct deletions/insertions of genes are mechanisms of a reversible or permanent silencing of gene expression, respectively.
T108 478-624 Sentence denotes Therefore, we investigated whether IRF-4 promoter methylation or mutation may be involved in the regulation of IRF-4 expression in leukemia cells.
T109 625-857 Sentence denotes Whereas promoter mutations or structural rearrangements could be excluded as a cause of altered IRF-4 expression in hematopoietic cells, the IRF-4 promoter methylation status was found to significantly influence IRF-4 transcription.
T110 858-1079 Sentence denotes First, treatment of IRF-4-negative lymphoid, myeloid and monocytic cell lines with the methylation-inhibitor 5-aza-2-deoxycytidine resulted in a time- and concentration-dependent increase of IRF-4 mRNA and protein levels.
T111 1080-1241 Sentence denotes Second, using a restriction-PCR-assay and bisulfite-sequencing we identified specifically methylated CpG sites in IRF-4-negative but not in IRF-4-positive cells.
T112 1242-1494 Sentence denotes Third, we clearly determined promoter methylation as a mechanism for IRF-4 down-regulation via reporter gene assays, but did not detect an association of methylational status and mRNA expression of DNA methyltransferases or methyl-CpG-binding proteins.
T113 1495-1640 Sentence denotes Together, these data suggest CpG site-specific IRF-4 promoter methylation as a putative mechanism of down-regulated IRF-4 expression in leukemia.
T3 0-308 Sentence denotes Although the bcr-abl translocation has been shown to be the causative genetic aberration in chronic myeloid leukemia (CML), there is mounting evidence that the deregulation of other genes, such as the transcription factor interferon regulatory factor 4 (IRF-4), is also implicated in the pathogenesis of CML.
T4 309-477 Sentence denotes Promoter methylation of CpG target sites or direct deletions/insertions of genes are mechanisms of a reversible or permanent silencing of gene expression, respectively.
T5 478-624 Sentence denotes Therefore, we investigated whether IRF-4 promoter methylation or mutation may be involved in the regulation of IRF-4 expression in leukemia cells.
T6 625-857 Sentence denotes Whereas promoter mutations or structural rearrangements could be excluded as a cause of altered IRF-4 expression in hematopoietic cells, the IRF-4 promoter methylation status was found to significantly influence IRF-4 transcription.
T7 858-1079 Sentence denotes First, treatment of IRF-4-negative lymphoid, myeloid and monocytic cell lines with the methylation-inhibitor 5-aza-2-deoxycytidine resulted in a time- and concentration-dependent increase of IRF-4 mRNA and protein levels.
T8 1080-1241 Sentence denotes Second, using a restriction-PCR-assay and bisulfite-sequencing we identified specifically methylated CpG sites in IRF-4-negative but not in IRF-4-positive cells.
T9 1242-1494 Sentence denotes Third, we clearly determined promoter methylation as a mechanism for IRF-4 down-regulation via reporter gene assays, but did not detect an association of methylational status and mRNA expression of DNA methyltransferases or methyl-CpG-binding proteins.
T10 1495-1640 Sentence denotes Together, these data suggest CpG site-specific IRF-4 promoter methylation as a putative mechanism of down-regulated IRF-4 expression in leukemia.

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T150 0-8 IN denotes Although
T151 9-12 DT denotes the
T152 13-20 NN denotes bcr-abl
T153 21-34 NN denotes translocation
T154 35-38 VB denotes has
T155 39-43 VB denotes been
T156 44-49 VB denotes shown
T157 50-52 TO denotes to
T158 53-55 VB denotes be
T159 56-59 DT denotes the
T160 60-69 JJ denotes causative
T161 70-77 JJ denotes genetic
T162 78-88 NN denotes aberration
T163 89-91 IN denotes in
T164 92-99 JJ denotes chronic
T165 100-107 JJ denotes myeloid
T166 108-116 NN denotes leukemia
T167 117-118 -LRB- denotes (
T168 118-121 NN denotes CML
T169 121-122 -RRB- denotes )
T170 122-123 -COMMA- denotes ,
T171 124-129 EX denotes there
T172 130-132 VB denotes is
T173 133-141 VB denotes mounting
T174 142-150 NN denotes evidence
T175 151-155 IN denotes that
T176 156-159 DT denotes the
T177 160-172 NN denotes deregulation
T178 173-175 IN denotes of
T179 176-181 JJ denotes other
T180 182-187 NN denotes genes
T181 187-188 -COMMA- denotes ,
T182 189-193 JJ denotes such
T183 194-196 IN denotes as
T184 197-200 DT denotes the
T185 201-214 NN denotes transcription
T186 215-221 NN denotes factor
T187 222-232 NN denotes interferon
T188 233-243 JJ denotes regulatory
T189 244-250 NN denotes factor
T190 251-252 CD denotes 4
T191 253-254 -LRB- denotes (
T192 254-259 NN denotes IRF-4
T193 259-260 -RRB- denotes )
T194 260-261 -COMMA- denotes ,
T195 262-264 VB denotes is
T196 265-269 RB denotes also
T197 270-280 VB denotes implicated
T198 281-283 IN denotes in
T199 284-287 DT denotes the
T200 288-300 NN denotes pathogenesis
T201 301-303 IN denotes of
T202 304-307 NN denotes CML
T203 309-317 NN denotes Promoter
T204 318-329 NN denotes methylation
T205 330-332 IN denotes of
T206 333-336 NN denotes CpG
T207 337-343 NN denotes target
T208 344-349 NN denotes sites
T209 350-352 CC denotes or
T210 353-359 JJ denotes direct
T211 360-380 NN denotes deletions/insertions
T212 381-383 IN denotes of
T213 384-389 NN denotes genes
T214 390-393 VB denotes are
T215 394-404 NN denotes mechanisms
T216 405-407 IN denotes of
T217 408-409 DT denotes a
T218 410-420 JJ denotes reversible
T219 421-423 CC denotes or
T220 424-433 JJ denotes permanent
T221 434-443 NN denotes silencing
T222 444-446 IN denotes of
T223 447-451 NN denotes gene
T224 452-462 NN denotes expression
T225 462-463 -COMMA- denotes ,
T226 464-476 RB denotes respectively
T227 478-487 RB denotes Therefore
T228 487-488 -COMMA- denotes ,
T229 489-491 PRP denotes we
T230 492-504 VB denotes investigated
T231 505-512 IN denotes whether
T232 513-518 NN denotes IRF-4
T233 519-527 NN denotes promoter
T234 528-539 NN denotes methylation
T235 540-542 CC denotes or
T236 543-551 NN denotes mutation
T237 552-555 MD denotes may
T238 556-558 VB denotes be
T239 559-567 VB denotes involved
T240 568-570 IN denotes in
T241 571-574 DT denotes the
T242 575-585 NN denotes regulation
T243 586-588 IN denotes of
T244 589-594 NN denotes IRF-4
T245 595-605 NN denotes expression
T246 606-608 IN denotes in
T247 609-617 NN denotes leukemia
T248 618-623 NN denotes cells
T249 625-632 IN denotes Whereas
T250 633-641 NN denotes promoter
T251 642-651 NN denotes mutations
T252 652-654 CC denotes or
T253 655-665 JJ denotes structural
T254 666-680 NN denotes rearrangements
T255 681-686 MD denotes could
T256 687-689 VB denotes be
T257 690-698 VB denotes excluded
T258 699-701 IN denotes as
T259 702-703 DT denotes a
T260 704-709 NN denotes cause
T261 710-712 IN denotes of
T262 713-720 VB denotes altered
T263 721-726 NN denotes IRF-4
T264 727-737 NN denotes expression
T265 738-740 IN denotes in
T266 741-754 JJ denotes hematopoietic
T267 755-760 NN denotes cells
T268 760-761 -COMMA- denotes ,
T269 762-765 DT denotes the
T270 766-771 NN denotes IRF-4
T271 772-780 NN denotes promoter
T272 781-792 NN denotes methylation
T273 793-799 NN denotes status
T274 800-803 VB denotes was
T275 804-809 VB denotes found
T276 810-812 TO denotes to
T277 813-826 RB denotes significantly
T278 827-836 VB denotes influence
T279 837-842 NN denotes IRF-4
T280 843-856 NN denotes transcription
T281 858-863 RB denotes First
T282 863-864 -COMMA- denotes ,
T283 865-874 NN denotes treatment
T284 875-877 IN denotes of
T285 878-892 JJ denotes IRF-4-negative
T286 893-901 JJ denotes lymphoid
T287 901-902 -COMMA- denotes ,
T288 903-910 JJ denotes myeloid
T289 911-914 CC denotes and
T290 915-924 JJ denotes monocytic
T291 925-929 NN denotes cell
T292 930-935 NN denotes lines
T293 936-940 IN denotes with
T294 941-944 DT denotes the
T295 945-966 NN denotes methylation-inhibitor
T296 967-988 NN denotes 5-aza-2-deoxycytidine
T297 989-997 VB denotes resulted
T298 998-1000 IN denotes in
T299 1001-1002 DT denotes a
T300 1003-1008 NN denotes time-
T301 1009-1012 CC denotes and
T302 1013-1036 JJ denotes concentration-dependent
T303 1037-1045 NN denotes increase
T304 1046-1048 IN denotes of
T305 1049-1054 NN denotes IRF-4
T306 1055-1059 NN denotes mRNA
T307 1060-1063 CC denotes and
T308 1064-1071 NN denotes protein
T309 1072-1078 NN denotes levels
T310 1080-1086 RB denotes Second
T311 1086-1087 -COMMA- denotes ,
T312 1088-1093 VB denotes using
T313 1094-1095 DT denotes a
T314 1096-1117 NN denotes restriction-PCR-assay
T315 1118-1121 CC denotes and
T316 1122-1142 NN denotes bisulfite-sequencing
T317 1143-1145 PRP denotes we
T318 1146-1156 VB denotes identified
T319 1157-1169 RB denotes specifically
T320 1170-1180 VB denotes methylated
T321 1181-1184 NN denotes CpG
T322 1185-1190 NN denotes sites
T323 1191-1193 IN denotes in
T324 1194-1208 JJ denotes IRF-4-negative
T325 1209-1212 CC denotes but
T326 1213-1216 RB denotes not
T327 1217-1219 IN denotes in
T328 1220-1234 JJ denotes IRF-4-positive
T329 1235-1240 NN denotes cells
T330 1242-1247 RB denotes Third
T331 1247-1248 -COMMA- denotes ,
T332 1249-1251 PRP denotes we
T333 1252-1259 RB denotes clearly
T334 1260-1270 VB denotes determined
T335 1271-1279 NN denotes promoter
T336 1280-1291 NN denotes methylation
T337 1292-1294 IN denotes as
T338 1295-1296 DT denotes a
T339 1297-1306 NN denotes mechanism
T340 1307-1310 IN denotes for
T341 1311-1316 NN denotes IRF-4
T342 1317-1332 NN denotes down-regulation
T343 1333-1336 IN denotes via
T344 1337-1345 NN denotes reporter
T345 1346-1350 NN denotes gene
T346 1351-1357 NN denotes assays
T347 1357-1358 -COMMA- denotes ,
T348 1359-1362 CC denotes but
T349 1363-1366 VB denotes did
T350 1367-1370 RB denotes not
T351 1371-1377 VB denotes detect
T352 1378-1380 DT denotes an
T353 1381-1392 NN denotes association
T354 1393-1395 IN denotes of
T355 1396-1409 JJ denotes methylational
T356 1410-1416 NN denotes status
T357 1417-1420 CC denotes and
T358 1421-1425 NN denotes mRNA
T359 1426-1436 NN denotes expression
T360 1437-1439 IN denotes of
T361 1440-1443 NN denotes DNA
T362 1444-1462 NN denotes methyltransferases
T363 1463-1465 CC denotes or
T364 1466-1484 JJ denotes methyl-CpG-binding
T365 1485-1493 NN denotes proteins
T366 1495-1503 RB denotes Together
T367 1503-1504 -COMMA- denotes ,
T368 1505-1510 DT denotes these
T369 1511-1515 NN denotes data
T370 1516-1523 VB denotes suggest
T371 1524-1527 NN denotes CpG
T372 1528-1541 JJ denotes site-specific
T373 1542-1547 NN denotes IRF-4
T374 1548-1556 NN denotes promoter
T375 1557-1568 NN denotes methylation
T376 1569-1571 IN denotes as
T377 1572-1573 DT denotes a
T378 1574-1582 JJ denotes putative
T379 1583-1592 NN denotes mechanism
T380 1593-1595 IN denotes of
T381 1596-1610 VB denotes down-regulated
T382 1611-1616 NN denotes IRF-4
T383 1617-1627 NN denotes expression
T384 1628-1630 IN denotes in
T385 1631-1639 NN denotes leukemia
R79 T166 T165 arg1Of leukemia,myeloid
R80 T166 T167 arg1Of leukemia,(
R81 T168 T167 arg2Of CML,(
R82 T169 T167 arg3Of ),(
R83 T171 T172 arg1Of there,is
R84 T172 T150 arg1Of is,Although
R85 T172 T170 arg1Of is,","
R86 T174 T172 arg2Of evidence,is
R87 T174 T173 arg1Of evidence,mounting
R88 T177 T176 arg1Of deregulation,the
R89 T177 T178 arg1Of deregulation,of
R90 T177 T195 arg1Of deregulation,is
R91 T177 T197 arg2Of deregulation,implicated
R92 T180 T178 arg2Of genes,of
R93 T180 T179 arg1Of genes,other
R94 T180 T181 arg1Of genes,","
R95 T180 T183 arg1Of genes,as
R96 T183 T182 arg1Of as,such
R97 T189 T183 arg2Of factor,as
R98 T189 T184 arg1Of factor,the
R99 T189 T185 arg1Of factor,transcription
R100 T189 T186 arg1Of factor,factor
R101 T189 T187 arg1Of factor,interferon
R102 T189 T188 arg1Of factor,regulatory
R114 T200 T199 arg1Of pathogenesis,the
R115 T200 T201 arg1Of pathogenesis,of
R116 T202 T201 arg2Of CML,of
R117 T204 T203 arg1Of methylation,Promoter
R118 T204 T205 arg1Of methylation,of
R119 T204 T214 arg1Of methylation,are
R120 T208 T206 arg1Of sites,CpG
R121 T208 T207 arg1Of sites,target
R122 T208 T209 arg1Of sites,or
R123 T209 T205 arg2Of or,of
R124 T211 T209 arg2Of deletions/insertions,or
R125 T211 T210 arg1Of deletions/insertions,direct
R126 T211 T212 arg1Of deletions/insertions,of
R127 T213 T212 arg2Of genes,of
R128 T214 T225 arg1Of are,","
R129 T214 T226 arg1Of are,respectively
R177 T260 T261 arg1Of cause,of
R178 T264 T261 arg2Of expression,of
R179 T264 T262 arg2Of expression,altered
R180 T264 T263 arg1Of expression,IRF-4
R181 T264 T265 arg1Of expression,in
R182 T267 T265 arg2Of cells,in
R183 T267 T266 arg1Of cells,hematopoietic
R184 T273 T269 arg1Of status,the
R185 T273 T270 arg1Of status,IRF-4
R186 T273 T271 arg1Of status,promoter
R187 T273 T272 arg1Of status,methylation
R188 T273 T274 arg1Of status,was
R61 T153 T151 arg1Of translocation,the
R62 T153 T152 arg1Of translocation,bcr-abl
R63 T153 T154 arg1Of translocation,has
R64 T153 T155 arg1Of translocation,been
R65 T153 T156 arg2Of translocation,shown
R66 T153 T158 arg1Of translocation,be
R67 T156 T150 arg2Of shown,Although
R68 T156 T154 arg2Of shown,has
R69 T156 T155 arg2Of shown,been
R70 T158 T156 arg3Of be,shown
R71 T158 T157 arg1Of be,to
R72 T158 T163 arg1Of be,in
R73 T162 T158 arg2Of aberration,be
R74 T162 T159 arg1Of aberration,the
R75 T162 T160 arg1Of aberration,causative
R76 T162 T161 arg1Of aberration,genetic
R77 T166 T163 arg2Of leukemia,in
R78 T166 T164 arg1Of leukemia,chronic
R103 T189 T190 arg1Of factor,4
R104 T189 T191 arg1Of factor,(
R105 T192 T191 arg2Of IRF-4,(
R106 T193 T191 arg3Of ),(
R107 T197 T174 arg2Of implicated,evidence
R108 T197 T175 arg1Of implicated,that
R109 T197 T194 arg1Of implicated,","
R110 T197 T195 arg2Of implicated,is
R111 T197 T196 arg1Of implicated,also
R112 T197 T198 arg1Of implicated,in
R113 T200 T198 arg2Of pathogenesis,in
R130 T215 T214 arg2Of mechanisms,are
R131 T215 T216 arg1Of mechanisms,of
R132 T218 T219 arg1Of reversible,or
R133 T220 T219 arg2Of permanent,or
R134 T221 T216 arg2Of silencing,of
R135 T221 T217 arg1Of silencing,a
R136 T221 T218 arg1Of silencing,reversible
R137 T221 T220 arg1Of silencing,permanent
R138 T221 T222 arg1Of silencing,of
R139 T224 T222 arg2Of expression,of
R140 T224 T223 arg1Of expression,gene
R141 T229 T230 arg1Of we,investigated
R142 T230 T227 arg1Of investigated,Therefore
R143 T230 T228 arg1Of investigated,","
R144 T234 T232 arg1Of methylation,IRF-4
R145 T234 T233 arg1Of methylation,promoter
R146 T234 T235 arg1Of methylation,or
R147 T235 T237 arg1Of or,may
R148 T235 T238 arg1Of or,be
R149 T235 T239 arg2Of or,involved
R150 T236 T235 arg2Of mutation,or
R151 T239 T230 arg2Of involved,investigated
R152 T239 T231 arg1Of involved,whether
R153 T239 T237 arg2Of involved,may
R154 T239 T238 arg2Of involved,be
R155 T239 T240 arg1Of involved,in
R156 T242 T240 arg2Of regulation,in
R157 T242 T241 arg1Of regulation,the
R158 T242 T243 arg1Of regulation,of
R159 T245 T243 arg2Of expression,of
R160 T245 T244 arg1Of expression,IRF-4
R161 T245 T246 arg1Of expression,in
R162 T248 T246 arg2Of cells,in
R163 T248 T247 arg1Of cells,leukemia
R164 T251 T250 arg1Of mutations,promoter
R165 T251 T252 arg1Of mutations,or
R166 T252 T255 arg1Of or,could
R167 T252 T256 arg1Of or,be
R168 T252 T257 arg2Of or,excluded
R169 T254 T252 arg2Of rearrangements,or
R170 T254 T253 arg1Of rearrangements,structural
R171 T257 T249 arg2Of excluded,Whereas
R172 T257 T255 arg2Of excluded,could
R173 T257 T256 arg2Of excluded,be
R174 T257 T258 arg1Of excluded,as
R175 T260 T258 arg2Of cause,as
R176 T260 T259 arg1Of cause,a
R189 T273 T275 arg2Of status,found
R190 T273 T278 arg1Of status,influence
R191 T275 T249 arg1Of found,Whereas
R192 T275 T268 arg1Of found,","
R193 T275 T274 arg2Of found,was
R194 T278 T275 arg3Of influence,found
R195 T278 T276 arg1Of influence,to
R196 T278 T277 arg1Of influence,significantly
R197 T280 T278 arg2Of transcription,influence
R198 T280 T279 arg1Of transcription,IRF-4
R199 T283 T284 arg1Of treatment,of
R200 T283 T297 arg1Of treatment,resulted
R201 T286 T287 arg1Of lymphoid,","
R202 T287 T289 arg1Of ",",and
R203 T288 T287 arg2Of myeloid,","
R204 T290 T289 arg2Of monocytic,and
R205 T292 T284 arg2Of lines,of
R206 T292 T285 arg1Of lines,IRF-4-negative
R207 T292 T286 arg1Of lines,lymphoid
R208 T292 T288 arg1Of lines,myeloid
R209 T292 T290 arg1Of lines,monocytic
R210 T292 T291 arg1Of lines,cell
R211 T292 T293 arg1Of lines,with
R212 T296 T293 arg2Of 5-aza-2-deoxycytidine,with
R213 T296 T294 arg1Of 5-aza-2-deoxycytidine,the
R214 T296 T295 arg1Of 5-aza-2-deoxycytidine,methylation-inhibitor
R215 T297 T281 arg1Of resulted,First
R216 T297 T282 arg1Of resulted,","
R217 T297 T298 arg1Of resulted,in
R218 T300 T301 arg1Of time-,and
R219 T302 T301 arg2Of concentration-dependent,and
R220 T303 T298 arg2Of increase,in
R221 T303 T299 arg1Of increase,a
R222 T303 T300 arg1Of increase,time-
R223 T303 T302 arg1Of increase,concentration-dependent
R224 T303 T304 arg1Of increase,of
R225 T306 T307 arg1Of mRNA,and
R226 T308 T307 arg2Of protein,and
R227 T309 T304 arg2Of levels,of
R228 T309 T305 arg1Of levels,IRF-4
R229 T309 T306 arg1Of levels,mRNA
R230 T309 T308 arg1Of levels,protein
R231 T314 T315 arg1Of restriction-PCR-assay,and
R232 T315 T312 arg2Of and,using
R233 T315 T313 arg1Of and,a
R234 T316 T315 arg2Of bisulfite-sequencing,and
R235 T317 T312 arg1Of we,using
R236 T317 T318 arg1Of we,identified
R237 T318 T310 arg1Of identified,Second
R238 T318 T311 arg1Of identified,","
R239 T318 T312 modOf identified,using
R240 T318 T323 arg1Of identified,in
R241 T318 T327 arg1Of identified,in
R242 T320 T319 arg1Of methylated,specifically
R243 T322 T318 arg2Of sites,identified
R244 T322 T320 arg1Of sites,methylated
R245 T322 T321 arg1Of sites,CpG
R246 T323 T325 arg1Of in,but
R247 T324 T323 arg2Of IRF-4-negative,in
R248 T327 T325 arg2Of in,but
R249 T327 T326 arg1Of in,not
R250 T329 T327 arg2Of cells,in
R251 T329 T328 arg1Of cells,IRF-4-positive
R252 T332 T334 arg1Of we,determined
R253 T332 T349 arg1Of we,did
R254 T332 T351 arg1Of we,detect
R255 T334 T337 arg1Of determined,as
R256 T334 T348 arg1Of determined,but
R257 T336 T334 arg2Of methylation,determined
R258 T336 T335 arg1Of methylation,promoter
R259 T339 T337 arg2Of mechanism,as
R260 T339 T338 arg1Of mechanism,a
R261 T339 T340 arg1Of mechanism,for
R262 T339 T343 arg1Of mechanism,via
R263 T342 T340 arg2Of down-regulation,for
R264 T342 T341 arg1Of down-regulation,IRF-4
R265 T346 T343 arg2Of assays,via
R266 T346 T344 arg1Of assays,reporter
R267 T346 T345 arg1Of assays,gene
R268 T348 T330 arg1Of but,Third
R269 T348 T331 arg1Of but,","
R270 T348 T333 arg1Of but,clearly
R271 T348 T347 arg1Of but,","
R272 T351 T348 arg2Of detect,but
R273 T351 T349 arg2Of detect,did
R274 T351 T350 arg1Of detect,not
R275 T353 T351 arg2Of association,detect
R276 T353 T352 arg1Of association,an
R277 T353 T354 arg1Of association,of
R278 T356 T357 arg1Of status,and
R279 T358 T357 arg2Of mRNA,and
R280 T359 T354 arg2Of expression,of
R281 T359 T355 arg1Of expression,methylational
R282 T359 T356 arg1Of expression,status
R283 T359 T358 arg1Of expression,mRNA
R284 T359 T360 arg1Of expression,of
R285 T362 T361 arg1Of methyltransferases,DNA
R286 T362 T363 arg1Of methyltransferases,or
R287 T363 T360 arg2Of or,of
R288 T365 T363 arg2Of proteins,or
R289 T365 T364 arg1Of proteins,methyl-CpG-binding
R290 T369 T368 arg1Of data,these
R291 T369 T370 arg1Of data,suggest
R292 T370 T366 arg1Of suggest,Together
R293 T370 T367 arg1Of suggest,","
R294 T370 T376 arg1Of suggest,as
R295 T375 T370 arg2Of methylation,suggest
R296 T375 T371 arg1Of methylation,CpG
R297 T375 T372 arg1Of methylation,site-specific
R298 T375 T373 arg1Of methylation,IRF-4
R299 T375 T374 arg1Of methylation,promoter
R300 T379 T376 arg2Of mechanism,as
R301 T379 T377 arg1Of mechanism,a
R302 T379 T378 arg1Of mechanism,putative
R303 T379 T380 arg1Of mechanism,of
R304 T379 T384 arg1Of mechanism,in
R305 T383 T380 arg2Of expression,of
R306 T383 T381 arg2Of expression,down-regulated
R307 T383 T382 arg1Of expression,IRF-4
R308 T385 T384 arg2Of leukemia,in

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T386 176-187 Anaphor denotes other genes
T387 222-252 Antecedent denotes interferon regulatory factor 4
R662 T386 T387 boundBy other genes,interferon regulatory factor 4

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T441 0-8 IN denotes Although
T442 9-12 DT denotes the
T443 13-20 JJ denotes bcr-abl
T444 21-34 NN denotes translocation
T445 35-38 VBZ denotes has
T446 39-43 VBN denotes been
T447 44-49 VBN denotes shown
T448 50-52 TO denotes to
T449 53-55 VB denotes be
T450 56-59 DT denotes the
T451 60-69 JJ denotes causative
T452 70-77 JJ denotes genetic
T453 78-88 NN denotes aberration
T454 89-91 IN denotes in
T455 92-99 JJ denotes chronic
T456 100-107 JJ denotes myeloid
T457 108-116 NN denotes leukemia
T458 117-118 -LRB- denotes (
T459 118-121 NNP denotes CML
T460 121-122 -RRB- denotes )
T461 122-123 , denotes ,
T462 124-129 EX denotes there
T463 130-132 VBZ denotes is
T464 133-141 VBG denotes mounting
T465 142-150 NN denotes evidence
T466 151-155 IN denotes that
T467 156-159 DT denotes the
T468 160-172 NN denotes deregulation
T469 173-175 IN denotes of
T470 176-181 JJ denotes other
T471 182-187 NNS denotes genes
T472 187-188 , denotes ,
T473 189-193 JJ denotes such
T474 194-196 IN denotes as
T475 197-200 DT denotes the
T476 201-214 NN denotes transcription
T477 215-221 NN denotes factor
T478 222-232 NN denotes interferon
T479 233-243 JJ denotes regulatory
T480 244-250 NN denotes factor
T481 251-252 CD denotes 4
T482 253-254 -LRB- denotes (
T483 254-259 NN denotes IRF-4
T484 259-260 -RRB- denotes )
T485 260-261 , denotes ,
T486 262-264 VBZ denotes is
T487 265-269 RB denotes also
T488 270-280 VBN denotes implicated
T489 281-283 IN denotes in
T490 284-287 DT denotes the
T491 288-300 NN denotes pathogenesis
T492 301-303 IN denotes of
T493 304-307 NNP denotes CML
T494 307-308 . denotes .
T495 309-317 NN denotes Promoter
T496 318-329 NN denotes methylation
T497 330-332 IN denotes of
T498 333-336 NNP denotes CpG
T499 337-343 NN denotes target
T500 344-349 NNS denotes sites
T501 350-352 CC denotes or
T502 353-359 JJ denotes direct
T503 360-380 NNS denotes deletions/insertions
T504 381-383 IN denotes of
T505 384-389 NNS denotes genes
T506 390-393 VBP denotes are
T507 394-404 NNS denotes mechanisms
T508 405-407 IN denotes of
T509 408-409 DT denotes a
T510 410-420 JJ denotes reversible
T511 421-423 CC denotes or
T512 424-433 JJ denotes permanent
T513 434-443 NN denotes silencing
T514 444-446 IN denotes of
T515 447-451 NN denotes gene
T516 452-462 NN denotes expression
T517 462-463 , denotes ,
T518 464-476 RB denotes respectively
T519 476-477 . denotes .
T520 478-487 RB denotes Therefore
T521 487-488 , denotes ,
T522 489-491 PRP denotes we
T523 492-504 VBD denotes investigated
T524 505-512 IN denotes whether
T525 513-518 NN denotes IRF-4
T526 519-527 NN denotes promoter
T527 528-539 NN denotes methylation
T528 540-542 CC denotes or
T529 543-551 NN denotes mutation
T530 552-555 MD denotes may
T531 556-558 VB denotes be
T532 559-567 VBN denotes involved
T533 568-570 IN denotes in
T534 571-574 DT denotes the
T535 575-585 NN denotes regulation
T536 586-588 IN denotes of
T537 589-594 NN denotes IRF-4
T538 595-605 NN denotes expression
T539 606-608 IN denotes in
T540 609-617 NN denotes leukemia
T541 618-623 NNS denotes cells
T542 623-624 . denotes .
T543 625-632 IN denotes Whereas
T544 633-641 NN denotes promoter
T545 642-651 NNS denotes mutations
T546 652-654 CC denotes or
T547 655-665 JJ denotes structural
T548 666-680 NNS denotes rearrangements
T549 681-686 MD denotes could
T550 687-689 VB denotes be
T551 690-698 VBN denotes excluded
T552 699-701 IN denotes as
T553 702-703 DT denotes a
T554 704-709 NN denotes cause
T555 710-712 IN denotes of
T556 713-720 JJ denotes altered
T557 721-726 NN denotes IRF-4
T558 727-737 NN denotes expression
T559 738-740 IN denotes in
T560 741-754 JJ denotes hematopoietic
T561 755-760 NNS denotes cells
T562 760-761 , denotes ,
T563 762-765 DT denotes the
T564 766-771 NNP denotes IRF-4
T565 772-780 NN denotes promoter
T566 781-792 NN denotes methylation
T567 793-799 NN denotes status
T568 800-803 VBD denotes was
T569 804-809 VBN denotes found
T570 810-812 TO denotes to
T571 813-826 RB denotes significantly
T572 827-836 VB denotes influence
T573 837-842 JJ denotes IRF-4
T574 843-856 NN denotes transcription
T575 856-857 . denotes .
T576 858-863 RB denotes First
T577 863-864 , denotes ,
T578 865-874 NN denotes treatment
T579 875-877 IN denotes of
T580 878-892 JJ denotes IRF-4-negative
T581 893-901 NN denotes lymphoid
T582 901-902 , denotes ,
T583 903-910 JJ denotes myeloid
T584 911-914 CC denotes and
T585 915-924 JJ denotes monocytic
T586 925-929 NN denotes cell
T587 930-935 NNS denotes lines
T588 936-940 IN denotes with
T589 941-944 DT denotes the
T590 945-966 NN denotes methylation-inhibitor
T591 967-988 JJ denotes 5-aza-2-deoxycytidine
T592 989-997 VBD denotes resulted
T593 998-1000 IN denotes in
T594 1001-1002 DT denotes a
T595 1003-1007 NN denotes time
T596 1007-1008 : denotes -
T597 1009-1012 CC denotes and
T598 1013-1036 JJ denotes concentration-dependent
T599 1037-1045 NN denotes increase
T600 1046-1048 IN denotes of
T601 1049-1054 NNP denotes IRF-4
T602 1055-1059 NNP denotes mRNA
T603 1060-1063 CC denotes and
T604 1064-1071 NN denotes protein
T605 1072-1078 NNS denotes levels
T606 1078-1079 . denotes .
T607 1080-1086 NNP denotes Second
T608 1086-1087 , denotes ,
T609 1088-1093 VBG denotes using
T610 1094-1095 DT denotes a
T611 1096-1117 JJ denotes restriction-PCR-assay
T612 1118-1121 CC denotes and
T613 1122-1142 JJ denotes bisulfite-sequencing
T614 1143-1145 PRP denotes we
T615 1146-1156 VBD denotes identified
T616 1157-1169 RB denotes specifically
T617 1170-1180 VBN denotes methylated
T618 1181-1184 NNP denotes CpG
T619 1185-1190 NNS denotes sites
T620 1191-1193 IN denotes in
T621 1194-1208 JJ denotes IRF-4-negative
T622 1209-1212 CC denotes but
T623 1213-1216 RB denotes not
T624 1217-1219 IN denotes in
T625 1220-1234 JJ denotes IRF-4-positive
T626 1235-1240 NNS denotes cells
T627 1240-1241 . denotes .
T628 1242-1247 NNP denotes Third
T629 1247-1248 , denotes ,
T630 1249-1251 PRP denotes we
T631 1252-1259 RB denotes clearly
T632 1260-1270 VBD denotes determined
T633 1271-1279 NN denotes promoter
T634 1280-1291 NN denotes methylation
T635 1292-1294 IN denotes as
T636 1295-1296 DT denotes a
T637 1297-1306 NN denotes mechanism
T638 1307-1310 IN denotes for
T639 1311-1316 NNP denotes IRF-4
T640 1317-1332 NN denotes down-regulation
T641 1333-1336 IN denotes via
T642 1337-1345 NN denotes reporter
T643 1346-1350 NN denotes gene
T644 1351-1357 NNS denotes assays
T645 1357-1358 , denotes ,
T646 1359-1362 CC denotes but
T647 1363-1366 VBD denotes did
T648 1367-1370 RB denotes not
T649 1371-1377 VB denotes detect
T650 1378-1380 DT denotes an
T651 1381-1392 NN denotes association
T652 1393-1395 IN denotes of
T653 1396-1409 JJ denotes methylational
T654 1410-1416 NN denotes status
T655 1417-1420 CC denotes and
T656 1421-1425 NNP denotes mRNA
T657 1426-1436 NN denotes expression
T658 1437-1439 IN denotes of
T659 1440-1443 NNP denotes DNA
T660 1444-1462 NNS denotes methyltransferases
T661 1463-1465 CC denotes or
T662 1466-1484 JJ denotes methyl-CpG-binding
T663 1485-1493 NNS denotes proteins
T664 1493-1494 . denotes .
T665 1495-1503 RB denotes Together
T666 1503-1504 , denotes ,
T667 1505-1510 DT denotes these
T668 1511-1515 NNS denotes data
T669 1516-1523 VBP denotes suggest
T670 1524-1527 NNP denotes CpG
T671 1528-1541 JJ denotes site-specific
T672 1542-1547 NN denotes IRF-4
T673 1548-1556 NN denotes promoter
T674 1557-1568 NN denotes methylation
T675 1569-1571 IN denotes as
T676 1572-1573 DT denotes a
T677 1574-1582 JJ denotes putative
T678 1583-1592 NN denotes mechanism
T679 1593-1595 IN denotes of
T680 1596-1610 JJ denotes down-regulated
T681 1611-1616 NN denotes IRF-4
T682 1617-1627 NN denotes expression
T683 1628-1630 IN denotes in
T684 1631-1639 NN denotes leukemia
T685 1639-1640 . denotes .
R343 T454 T453 prep in,aberration
R344 T455 T457 amod chronic,leukemia
R345 T456 T457 amod myeloid,leukemia
R346 T457 T454 pobj leukemia,in
R347 T458 T459 punct (,CML
R348 T459 T457 appos CML,leukemia
R445 T556 T558 amod altered,expression
R446 T557 T558 compound IRF-4,expression
R447 T558 T555 pobj expression,of
R448 T559 T558 prep in,expression
R449 T560 T561 amod hematopoietic,cells
R450 T561 T559 pobj cells,in
R451 T562 T569 punct ",",found
R452 T563 T567 det the,status
R453 T564 T567 compound IRF-4,status
R454 T565 T567 compound promoter,status
R515 T626 T624 pobj cells,in
R516 T627 T615 punct .,identified
R517 T628 T632 npadvmod Third,determined
R518 T629 T632 punct ",",determined
R519 T630 T632 nsubj we,determined
R520 T631 T632 advmod clearly,determined
R521 T632 T632 ROOT determined,determined
R522 T633 T634 compound promoter,methylation
R523 T634 T632 dobj methylation,determined
R524 T635 T632 prep as,determined
R525 T636 T637 det a,mechanism
R526 T637 T635 pobj mechanism,as
R527 T638 T637 prep for,mechanism
R528 T639 T640 compound IRF-4,down-regulation
R529 T640 T638 pobj down-regulation,for
R530 T641 T632 prep via,determined
R330 T441 T447 mark Although,shown
R331 T442 T444 det the,translocation
R332 T443 T444 amod bcr-abl,translocation
R333 T444 T447 nsubjpass translocation,shown
R334 T445 T447 aux has,shown
R335 T446 T447 auxpass been,shown
R336 T447 T463 advcl shown,is
R337 T448 T449 aux to,be
R338 T449 T447 xcomp be,shown
R339 T450 T453 det the,aberration
R340 T451 T453 amod causative,aberration
R341 T452 T453 amod genetic,aberration
R342 T453 T449 attr aberration,be
R349 T460 T447 punct ),shown
R350 T461 T463 punct ",",is
R351 T462 T463 expl there,is
R352 T463 T463 ROOT is,is
R353 T464 T465 amod mounting,evidence
R354 T465 T463 attr evidence,is
R355 T466 T488 mark that,implicated
R356 T467 T468 det the,deregulation
R357 T468 T488 nsubjpass deregulation,implicated
R358 T469 T468 prep of,deregulation
R359 T470 T471 amod other,genes
R360 T471 T469 pobj genes,of
R361 T472 T471 punct ",",genes
R362 T473 T474 amod such,as
R363 T474 T471 prep as,genes
R364 T475 T480 det the,factor
R365 T476 T477 compound transcription,factor
R366 T477 T480 nmod factor,factor
R367 T478 T480 nmod interferon,factor
R368 T479 T480 amod regulatory,factor
R369 T480 T474 pobj factor,as
R370 T481 T480 nummod 4,factor
R371 T482 T480 punct (,factor
R372 T483 T480 appos IRF-4,factor
R373 T484 T480 punct ),factor
R374 T485 T486 punct ",",is
R375 T486 T488 auxpass is,implicated
R376 T487 T488 advmod also,implicated
R377 T488 T465 acl implicated,evidence
R378 T489 T488 prep in,implicated
R379 T490 T491 det the,pathogenesis
R380 T491 T489 pobj pathogenesis,in
R381 T492 T491 prep of,pathogenesis
R410 T521 T523 punct ",",investigated
R411 T522 T523 nsubj we,investigated
R412 T523 T523 ROOT investigated,investigated
R413 T524 T532 mark whether,involved
R414 T525 T527 compound IRF-4,methylation
R415 T526 T527 compound promoter,methylation
R416 T527 T532 nsubjpass methylation,involved
R417 T528 T527 cc or,methylation
R418 T529 T527 conj mutation,methylation
R419 T530 T532 aux may,involved
R420 T531 T532 auxpass be,involved
R421 T532 T523 ccomp involved,investigated
R422 T533 T532 prep in,involved
R423 T534 T535 det the,regulation
R424 T535 T533 pobj regulation,in
R425 T536 T535 prep of,regulation
R426 T537 T538 compound IRF-4,expression
R427 T538 T536 pobj expression,of
R428 T539 T535 prep in,regulation
R429 T540 T541 compound leukemia,cells
R430 T541 T539 pobj cells,in
R431 T542 T523 punct .,investigated
R432 T543 T551 mark Whereas,excluded
R433 T544 T545 compound promoter,mutations
R434 T545 T551 nsubjpass mutations,excluded
R435 T546 T545 cc or,mutations
R436 T547 T548 amod structural,rearrangements
R437 T548 T545 conj rearrangements,mutations
R438 T549 T551 aux could,excluded
R439 T550 T551 auxpass be,excluded
R440 T551 T569 advcl excluded,found
R441 T552 T551 prep as,excluded
R442 T553 T554 det a,cause
R443 T554 T552 pobj cause,as
R444 T555 T554 prep of,cause
R455 T566 T567 compound methylation,status
R456 T567 T569 nsubjpass status,found
R457 T568 T569 auxpass was,found
R458 T569 T569 ROOT found,found
R459 T570 T572 aux to,influence
R460 T571 T572 advmod significantly,influence
R461 T572 T569 xcomp influence,found
R462 T573 T574 compound IRF-4,transcription
R463 T574 T572 dobj transcription,influence
R464 T575 T569 punct .,found
R465 T576 T592 advmod First,resulted
R466 T577 T592 punct ",",resulted
R467 T578 T592 nsubj treatment,resulted
R468 T579 T578 prep of,treatment
R469 T580 T581 amod IRF-4-negative,lymphoid
R470 T581 T579 pobj lymphoid,of
R471 T582 T581 punct ",",lymphoid
R472 T583 T581 conj myeloid,lymphoid
R473 T584 T583 cc and,myeloid
R474 T585 T583 conj monocytic,myeloid
R475 T586 T587 compound cell,lines
R476 T587 T578 pobj lines,treatment
R477 T588 T587 prep with,lines
R478 T589 T591 det the,5-aza-2-deoxycytidine
R479 T590 T591 compound methylation-inhibitor,5-aza-2-deoxycytidine
R480 T591 T588 pobj 5-aza-2-deoxycytidine,with
R481 T592 T592 ROOT resulted,resulted
R482 T593 T592 prep in,resulted
R483 T594 T595 det a,time
R484 T595 T593 pobj time,in
R485 T596 T592 punct -,resulted
R486 T597 T592 cc and,resulted
R487 T598 T599 amod concentration-dependent,increase
R488 T599 T605 nmod increase,levels
R489 T600 T599 prep of,increase
R490 T601 T602 compound IRF-4,mRNA
R491 T602 T600 pobj mRNA,of
R492 T603 T599 cc and,increase
R493 T604 T605 compound protein,levels
R494 T605 T592 conj levels,resulted
R495 T606 T592 punct .,resulted
R496 T607 T615 advmod Second,identified
R497 T608 T615 punct ",",identified
R498 T609 T615 advcl using,identified
R499 T610 T615 npadvmod a,identified
R500 T611 T615 npadvmod restriction-PCR-assay,identified
R501 T612 T611 cc and,restriction-PCR-assay
R502 T613 T611 conj bisulfite-sequencing,restriction-PCR-assay
R503 T614 T615 nsubj we,identified
R504 T615 T615 ROOT identified,identified
R505 T616 T617 advmod specifically,methylated
R506 T617 T619 amod methylated,sites
R507 T618 T619 compound CpG,sites
R508 T619 T615 dobj sites,identified
R509 T620 T619 prep in,sites
R510 T621 T620 pobj IRF-4-negative,in
R511 T622 T621 cc but,IRF-4-negative
R512 T623 T620 neg not,in
R513 T624 T620 prep in,in
R514 T625 T626 amod IRF-4-positive,cells
R531 T642 T644 compound reporter,assays
R532 T643 T644 compound gene,assays
R533 T644 T641 pobj assays,via
R534 T645 T632 punct ",",determined
R535 T646 T632 cc but,determined
R536 T647 T649 aux did,detect
R537 T648 T649 neg not,detect
R538 T649 T632 conj detect,determined
R539 T650 T651 det an,association
R540 T651 T649 dobj association,detect
R541 T652 T651 prep of,association
R542 T653 T654 amod methylational,status
R543 T654 T652 pobj status,of
R544 T655 T649 cc and,detect
R545 T656 T657 compound mRNA,expression
R546 T657 T649 conj expression,detect
R547 T658 T657 prep of,expression
R548 T659 T660 compound DNA,methyltransferases
R549 T660 T658 pobj methyltransferases,of
R550 T661 T660 cc or,methyltransferases
R551 T662 T663 amod methyl-CpG-binding,proteins
R552 T663 T660 conj proteins,methyltransferases
R553 T664 T632 punct .,determined
R554 T665 T669 advmod Together,suggest
R555 T666 T669 punct ",",suggest
R556 T667 T668 det these,data
R557 T668 T669 nsubj data,suggest
R558 T669 T669 ROOT suggest,suggest
R559 T670 T674 nmod CpG,methylation
R560 T671 T672 amod site-specific,IRF-4
R561 T672 T674 compound IRF-4,methylation
R562 T673 T674 compound promoter,methylation
R563 T674 T669 dobj methylation,suggest
R564 T675 T669 prep as,suggest
R565 T676 T678 det a,mechanism
R566 T677 T678 amod putative,mechanism
R567 T678 T675 pobj mechanism,as
R568 T679 T678 prep of,mechanism
R569 T680 T682 amod down-regulated,expression
R570 T681 T682 compound IRF-4,expression
R571 T682 T679 pobj expression,of
R572 T683 T678 prep in,mechanism
R573 T684 T683 pobj leukemia,in
R574 T685 T669 punct .,suggest
R400 T511 T510 cc or,reversible
R401 T512 T510 conj permanent,reversible
R402 T513 T508 pobj silencing,of
R403 T514 T513 prep of,silencing
R404 T515 T516 compound gene,expression
R405 T516 T514 pobj expression,of
R406 T517 T513 punct ",",silencing
R407 T518 T506 advmod respectively,are
R408 T519 T506 punct .,are
R409 T520 T523 advmod Therefore,investigated
R382 T493 T492 pobj CML,of
R383 T494 T463 punct .,is
R384 T495 T496 compound Promoter,methylation
R385 T496 T506 nsubj methylation,are
R386 T497 T496 prep of,methylation
R387 T498 T500 compound CpG,sites
R388 T499 T500 compound target,sites
R389 T500 T497 pobj sites,of
R390 T501 T500 cc or,sites
R391 T502 T503 amod direct,deletions/insertions
R392 T503 T500 conj deletions/insertions,sites
R393 T504 T503 prep of,deletions/insertions
R394 T505 T504 pobj genes,of
R395 T506 T506 ROOT are,are
R396 T507 T506 attr mechanisms,are
R397 T508 T507 prep of,mechanisms
R398 T509 T513 det a,silencing
R399 T510 T513 amod reversible,silencing

GO-BP

Id Subject Object Predicate Lexical cue
T115 575-585 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T116 1322-1332 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T118 447-462 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T119 201-214 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T120 843-856 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T121 288-300 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T122 318-329 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T123 528-539 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T124 781-792 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T125 945-956 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T126 1280-1291 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T127 1557-1568 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T128 434-451 http://purl.obolibrary.org/obo/GO_0016458 denotes silencing of gene

GO-MF

Id Subject Object Predicate Lexical cue
T695 1466-1484 http://purl.obolibrary.org/obo/GO_0008327 denotes methyl-CpG-binding
T696 1477-1484 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T697 1477-1493 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T841 13-16 Protein denotes bcr
T842 17-20 Protein denotes abl
T843 222-252 Protein denotes interferon regulatory factor 4
T844 254-259 Protein denotes IRF-4
T845 160-172 Regulation denotes deregulation
T846 160-172 Regulation denotes deregulation
T847 513-527 Protein denotes IRF-4 promoter
T848 589-594 Protein denotes IRF-4
T849 595-605 Gene_expression denotes expression
T850 575-585 Regulation denotes regulation
T851 721-726 Protein denotes IRF-4
T852 766-780 Protein denotes IRF-4 promoter
T853 837-842 Protein denotes IRF-4
T854 727-737 Gene_expression denotes expression
T855 843-856 Transcription denotes transcription
T856 713-720 Regulation denotes altered
T857 827-836 Regulation denotes influence
T858 1049-1059 Protein denotes IRF-4 mRNA
T859 1037-1045 Positive_regulation denotes increase
T860 1220-1225 Protein denotes IRF-4
T861 1226-1234 Gene_expression denotes positive
T862 1311-1316 Protein denotes IRF-4
T863 1317-1332 Negative_regulation denotes down-regulation
T864 1542-1556 Protein denotes IRF-4 promoter
T865 1611-1616 Protein denotes IRF-4
T866 1617-1627 Gene_expression denotes expression
T867 1596-1610 Negative_regulation denotes down-regulated
R617 T843 T845 themeOf interferon regulatory factor 4,deregulation
R618 T844 T846 themeOf IRF-4,deregulation
R619 T848 T849 themeOf IRF-4,expression
R620 T849 T850 themeOf expression,regulation
R621 T851 T854 themeOf IRF-4,expression
R622 T853 T855 themeOf IRF-4,transcription
R623 T854 T856 themeOf expression,altered
R624 T855 T857 themeOf transcription,influence
R625 T858 T859 themeOf IRF-4 mRNA,increase
R626 T860 T861 themeOf IRF-4,positive
R627 T862 T863 themeOf IRF-4,down-regulation
R628 T865 T866 themeOf IRF-4,expression
R629 T866 T867 themeOf expression,down-regulated

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T97 1220-1225 Protein denotes IRF-4
T98 1226-1234 Gene_expression denotes positive
T99 1311-1316 Protein denotes IRF-4
T100 1317-1332 Negative_regulation denotes down-regulation
T101 1542-1547 Protein denotes IRF-4
T102 1596-1610 Negative_regulation denotes down-regulated true
T103 1611-1616 Protein denotes IRF-4
T104 1617-1627 Gene_expression denotes expression
T74 13-16 Protein denotes bcr
T75 17-20 Protein denotes abl
T76 160-172 Regulation denotes deregulation true
T77 222-252 Protein denotes interferon regulatory factor 4
T78 254-259 Protein denotes IRF-4
T79 513-518 Protein denotes IRF-4
T80 575-585 Regulation denotes regulation true
T81 589-594 Protein denotes IRF-4
T82 595-605 Gene_expression denotes expression
T83 713-720 Regulation denotes altered
T84 721-726 Protein denotes IRF-4
T85 727-737 Gene_expression denotes expression
T86 766-771 Protein denotes IRF-4
T87 827-836 Regulation denotes influence
T88 837-842 Protein denotes IRF-4
T89 843-856 Transcription denotes transcription
T90 878-883 Protein denotes IRF-4
T91 884-892 Gene_expression denotes negative true
T92 989-997 Positive_regulation denotes resulted
T93 1037-1045 Positive_regulation denotes increase
T94 1049-1054 Protein denotes IRF-4
T95 1194-1199 Protein denotes IRF-4
T96 1200-1208 Gene_expression denotes negative true
R654 T84 T85 themeOf IRF-4,expression
R656 T88 T89 themeOf IRF-4,transcription
R657 T89 T87 themeOf transcription,influence
R658 T90 T91 themeOf IRF-4,negative
R659 T93 T92 themeOf increase,resulted
R37 T97 T98 themeOf IRF-4,positive
R38 T99 T100 themeOf IRF-4,down-regulation
R39 T103 T104 themeOf IRF-4,expression
R40 T104 T102 themeOf expression,down-regulated
R650 T77 T76 themeOf interferon regulatory factor 4,deregulation
R651 T78 T77 equivalentTo IRF-4,interferon regulatory factor 4
R652 T81 T82 themeOf IRF-4,expression
R653 T82 T80 themeOf expression,regulation
R655 T85 T83 themeOf expression,altered
R660 T94 T93 themeOf IRF-4,increase
R661 T95 T96 themeOf IRF-4,negative

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T393 13-16 P11274 denotes bcr
T394 17-20 P00519 denotes abl
T395 222-252 Q92985 denotes interferon regulatory factor 4
T396 222-252 Q13568 denotes interferon regulatory factor 4
T397 222-252 Q14653 denotes interferon regulatory factor 4
T398 222-252 Q15306 denotes interferon regulatory factor 4
T399 222-252 Q02556 denotes interferon regulatory factor 4
T400 254-259 Q15306 denotes IRF-4
T401 513-518 Q15306 denotes IRF-4
T402 589-594 Q15306 denotes IRF-4
T403 721-726 Q15306 denotes IRF-4
T404 766-771 Q15306 denotes IRF-4
T405 837-842 Q15306 denotes IRF-4
T406 878-883 Q15306 denotes IRF-4
T407 1049-1054 Q15306 denotes IRF-4
T408 1194-1199 Q15306 denotes IRF-4
T409 1220-1225 Q15306 denotes IRF-4
T410 1311-1316 Q15306 denotes IRF-4
T411 1440-1462 O95243 denotes DNA methyltransferases
T412 1440-1462 P26358 denotes DNA methyltransferases
T413 1440-1462 Q9UIS9 denotes DNA methyltransferases
T414 1440-1462 Q9Y6K1 denotes DNA methyltransferases
T415 1440-1462 Q9UBC3 denotes DNA methyltransferases
T416 1440-1462 Q9UBB5 denotes DNA methyltransferases
T417 1466-1493 P51608 denotes methyl-CpG-binding proteins
T418 1542-1547 Q15306 denotes IRF-4
T419 1611-1616 Q15306 denotes IRF-4

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T38 13-16 Protein denotes bcr true
T39 17-20 Protein denotes abl
T40 21-34 Localization denotes translocation
T41 222-252 Protein denotes interferon regulatory factor 4
T42 254-259 Protein denotes IRF-4
T43 513-518 Protein denotes IRF-4
T44 575-585 Regulation denotes regulation true
T45 589-594 Protein denotes IRF-4
T46 595-605 Gene_expression denotes expression
T47 713-720 Regulation denotes altered true
T48 721-726 Protein denotes IRF-4
T49 727-737 Gene_expression denotes expression
T50 766-771 Protein denotes IRF-4 true
T51 827-836 Regulation denotes influence
T52 837-842 Protein denotes IRF-4
T53 843-856 Transcription denotes transcription
T54 878-883 Protein denotes IRF-4
T55 884-892 Gene_expression denotes negative
T56 1027-1036 Regulation denotes dependent
T57 1037-1045 Positive_regulation denotes increase
T58 1049-1054 Protein denotes IRF-4
T59 1194-1199 Protein denotes IRF-4
T60 1200-1208 Gene_expression denotes negative
T61 1220-1225 Protein denotes IRF-4
T62 1226-1234 Gene_expression denotes positive
T63 1311-1316 Protein denotes IRF-4
T64 1317-1332 Negative_regulation denotes down-regulation
T65 1381-1392 Binding denotes association
T66 1421-1425 Transcription denotes mRNA
T67 1542-1547 Protein denotes IRF-4
T68 1596-1610 Negative_regulation denotes down-regulated
T69 1611-1616 Protein denotes IRF-4
T70 1617-1627 Gene_expression denotes expression
R21 T38 T40 themeOf bcr,translocation
R22 T42 T41 equivalentTo IRF-4,interferon regulatory factor 4
R23 T45 T46 themeOf IRF-4,expression
R24 T46 T44 themeOf expression,regulation
R25 T48 T49 themeOf IRF-4,expression
R26 T49 T47 themeOf expression,altered
R27 T52 T53 themeOf IRF-4,transcription
R28 T53 T51 themeOf transcription,influence
R29 T54 T55 themeOf IRF-4,negative
R30 T57 T56 themeOf increase,dependent
R31 T58 T57 themeOf IRF-4,increase
R32 T59 T60 themeOf IRF-4,negative
R33 T61 T62 themeOf IRF-4,positive
R34 T63 T64 themeOf IRF-4,down-regulation
R35 T69 T70 themeOf IRF-4,expression
R36 T70 T68 themeOf expression,down-regulated