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bionlp-st-ge-2016-reference-eval

Id Subject Object Predicate Lexical cue
T868 0-15 Negative_regulation denotes Down-regulation
T869 19-49 Protein denotes interferon regulatory factor 4
T870 55-65 Gene_expression denotes expression
T871 169-172 Protein denotes bcr
T872 173-176 Protein denotes abl
T873 316-328 Regulation denotes deregulation
T874 378-408 Protein denotes interferon regulatory factor 4
T875 410-415 Protein denotes IRF-4
T876 669-674 Protein denotes IRF-4
T877 731-741 Regulation denotes regulation
T878 745-750 Protein denotes IRF-4
T879 751-761 Gene_expression denotes expression
T880 869-876 Regulation denotes altered
T881 877-882 Protein denotes IRF-4
T882 883-893 Gene_expression denotes expression
T883 922-927 Protein denotes IRF-4
T884 983-992 Regulation denotes influence
T885 993-998 Protein denotes IRF-4
T886 999-1012 Transcription denotes transcription
T887 1034-1039 Protein denotes IRF-4
T888 1040-1048 Gene_expression denotes negative
T889 1145-1153 Positive_regulation denotes resulted
T890 1193-1201 Positive_regulation denotes increase
T891 1205-1210 Protein denotes IRF-4
T892 1350-1355 Protein denotes IRF-4
T893 1356-1364 Gene_expression denotes negative
T894 1376-1381 Protein denotes IRF-4
T895 1382-1390 Gene_expression denotes positive
T896 1467-1472 Protein denotes IRF-4
T897 1473-1488 Negative_regulation denotes down-regulation
T898 1698-1703 Protein denotes IRF-4
T899 1752-1766 Negative_regulation denotes down-regulated
T900 1767-1772 Protein denotes IRF-4
T901 1773-1783 Gene_expression denotes expression
T2650 2172-2179 Positive_regulation denotes leading
T2651 3355-3363 Negative_regulation denotes deletion
T2652 3466-3476 Gene_expression denotes expression
T2653 4272-4280 Regulation denotes regulate
T2654 4281-4291 Gene_expression denotes expression
T2655 4272-4280 Regulation denotes regulate
T2656 4281-4291 Gene_expression denotes expression
T2657 4948-4958 Gene_expression denotes expression
T2658 4959-4968 Negative_regulation denotes silencing
T2659 5084-5092 Gene_expression denotes positive
T2660 5098-5106 Gene_expression denotes negative
T2661 2183-2193 Gene_expression denotes expression
T2662 2446-2454 Negative_regulation denotes impaired
T2663 2455-2465 Gene_expression denotes expression
T2664 2592-2601 Negative_regulation denotes silencing
T2665 3002-3012 Gene_expression denotes expression
T2666 3077-3085 Gene_expression denotes positive
T2667 3121-3131 Gene_expression denotes expression
T2668 3151-3158 Positive_regulation denotes induced
T2669 2199-2218 Protein denotes bcr-abl fusion gene
T2670 2951-2954 Protein denotes Pip
T2671 2955-2959 Protein denotes MUM1
T2672 2960-2965 Protein denotes LSIRF
T2673 3071-3076 Protein denotes IRF-4
T2674 3135-3140 Protein denotes IRF-4
T2675 3367-3372 Protein denotes IRF-4
T2676 3480-3485 Protein denotes IRF-4
T2677 3571-3576 Protein denotes IRF-4
T2678 4167-4171 Protein denotes MGMT
T2679 4173-4177 Protein denotes DAPK
T2680 2278-2290 Protein denotes interferon α
T2681 4179-4185 Protein denotes p14ARF
T2682 4187-4195 Protein denotes p15INK4b
T2683 4197-4205 Protein denotes p16INK4a
T2684 4207-4212 Protein denotes BRCA1
T2685 4214-4219 Protein denotes CDH13
T2686 4224-4230 Protein denotes APAF-1
T2687 4299-4304 Protein denotes c-abl
T2688 4310-4313 Protein denotes bcr
T2689 4376-4381 Protein denotes c-abl
T2690 4937-4942 Protein denotes IRF-4
T2691 2292-2297 Protein denotes IFN-α
T2692 5004-5009 Protein denotes IRF-4
T2693 5078-5083 Protein denotes IRF-4
T2694 2473-2503 Protein denotes interferon regulatory factor 4
T2695 2505-2510 Protein denotes IRF-4
T2696 2554-2559 Protein denotes IFN-α
T2697 2605-2610 Protein denotes IRF-4
T2698 2938-2943 Protein denotes IRF-4
T2699 2945-2950 Protein denotes ICSAT
T2700 2635-2664 Protein denotes Interferon regulatory factors
T2852 5482-5490 Gene_expression denotes negative
T2853 5476-5481 Protein denotes IRF-4
T2854 5163-5168 Protein denotes K-562
T2855 5170-5176 Protein denotes Jurkat
T2856 5181-5186 Protein denotes U-937
T3045 5602-5607 Protein denotes Gibco
T3046 5608-5611 Protein denotes BRL
T3361 5991-6005 Protein denotes IRF-4 promoter
T3362 6026-6040 Protein denotes IRF-4 promoter
T4319 6851-6866 Transcription denotes transcriptional
T4320 7273-7283 Gene_expression denotes expression
T4321 7419-7429 Gene_expression denotes expression
T4322 7052-7066 Transcription denotes RNA expression
T4323 7052-7066 Transcription denotes RNA expression
T4324 7273-7283 Gene_expression denotes expression
T4325 7273-7283 Gene_expression denotes expression
T4326 7273-7283 Gene_expression denotes expression
T4327 7273-7283 Gene_expression denotes expression
T4328 7273-7283 Gene_expression denotes expression
T4329 7273-7283 Gene_expression denotes expression
T4330 6845-6850 Protein denotes IRF-4
T4331 7352-7356 Protein denotes MBD4
T4332 7405-7410 Protein denotes IRF-4
T4333 8615-8620 Protein denotes IRF-4
T4334 8621-8626 Protein denotes ICSAT
T4335 8628-8632 Protein denotes M-17
T4336 8692-8699 Protein denotes β-actin
T4337 7080-7085 Protein denotes IRF-4
T4338 7109-7116 Protein denotes β-actin
T4339 7309-7314 Protein denotes DNMT1
T4340 7315-7321 Protein denotes DNMT3A
T4341 7323-7329 Protein denotes DNMT3B
T4342 7331-7335 Protein denotes MeCP
T4343 7337-7341 Protein denotes MBD1
T4344 7343-7347 Protein denotes MBD2
T4345 7296-7300 Protein denotes DNMT
T4346 7304-7307 Protein denotes MBP
T5650 11328-11333 Protein denotes IRF-4
T6113 12569-12579 Gene_expression denotes expressing
T6114 12627-12636 Gene_expression denotes expressed
T6115 12892-12902 Positive_regulation denotes activation
T6116 12107-12112 Protein denotes IRF-4
T6117 12883-12891 Entity denotes promoter
T6118 12414-12424 Protein denotes luciferase
T6119 12592-12602 Protein denotes luciferase
T6120 12779-12789 Protein denotes luciferase
T6121 12877-12882 Protein denotes IRF-4
T6887 13058-13065 Negative_regulation denotes Absence
T6888 13571-13579 Gene_expression denotes positive
T6889 13674-13682 Gene_expression denotes positive
T6890 13782-13789 Negative_regulation denotes absence
T6891 13799-13809 Gene_expression denotes expression
T6892 13970-13978 Gene_expression denotes positive
T6893 14000-14008 Gene_expression denotes negative
T6894 13075-13085 Gene_expression denotes expression
T6895 13111-13114 Positive_regulation denotes due
T6896 13173-13177 Negative_regulation denotes lack
T6897 13187-13197 Gene_expression denotes expression
T6898 13298-13308 Gene_expression denotes expression
T6899 13399-13407 Gene_expression denotes positive
T6900 13438-13445 Gene_expression denotes positve
T6901 13518-13525 Gene_expression denotes positve
T6902 13069-13074 Protein denotes IRF-4
T6903 13793-13798 Protein denotes IRF-4
T6904 13964-13969 Protein denotes IRF-4
T6905 13994-13999 Protein denotes IRF-4
T6906 13181-13186 Protein denotes IRF-4
T6907 13292-13297 Protein denotes IRF-4
T6908 13391-13398 Protein denotes bcr-abl
T6909 13430-13437 Protein denotes bcr-abl
T6910 13510-13517 Protein denotes bcr-abl
T6911 13563-13570 Protein denotes bcr-abl
T6912 13666-13673 Protein denotes bcr-abl
T6913 13740-13745 Protein denotes IRF-4
T7764 15539-15547 Gene_expression denotes positive
T7765 15603-15609 Regulation denotes effect
T7766 15619-15629 Gene_expression denotes expression
T7767 15712-15721 Positive_regulation denotes increased
T7768 15732-15742 Transcription denotes mRNA level
T7769 15828-15835 Regulation denotes control
T7770 15842-15852 Gene_expression denotes expression
T7771 14504-14514 Gene_expression denotes expression
T7772 14925-14935 Positive_regulation denotes activation
T7773 14945-14958 Transcription denotes transcription
T7774 15054-15067 Transcription denotes transcription
T7775 15072-15079 Positive_regulation denotes induced
T7776 15172-15181 Positive_regulation denotes increased
T7777 15261-15272 Transcription denotes transcripts
T7778 15726-15731 Protein denotes IRF-4
T7779 15836-15841 Protein denotes IRF-4
T7780 15945-15950 Protein denotes IRF-4
T7781 14498-14503 Protein denotes IRF-4
T7782 14548-14553 Protein denotes IRF-4
T7783 14939-14944 Protein denotes IRF-4
T7784 15048-15053 Protein denotes IRF-4
T7785 15255-15260 Protein denotes IRF-4
T7786 15465-15470 Protein denotes IRF-4
T7787 15533-15538 Protein denotes IRF-4
T7788 15613-15618 Protein denotes IRF-4
T8464 16157-16167 Gene_expression denotes expression
T8465 16834-16842 Gene_expression denotes negative
T8466 17024-17032 Gene_expression denotes positive
T8467 17151-17159 Gene_expression denotes positive
T8468 17363-17376 Transcription denotes transcription
T8469 17519-17527 Gene_expression denotes negative
T8470 16035-16040 Protein denotes IRF-4
T8471 16146-16151 Protein denotes IRF-4
T8472 16539-16544 Protein denotes IRF-4
T8473 16828-16833 Protein denotes IRF-4
T8474 17018-17023 Protein denotes IRF-4
T8475 17145-17150 Protein denotes IRF-4
T8476 17357-17362 Protein denotes IRF-4
T8477 17513-17518 Protein denotes IRF-4
T9617 18330-18338 Gene_expression denotes positive
T9618 19571-19579 Gene_expression denotes negative
T9619 19703-19713 Regulation denotes regulation
T9620 19723-19733 Gene_expression denotes expression
T9621 18399-18407 Gene_expression denotes negative
T9622 19102-19110 Gene_expression denotes negative
T9623 19216-19224 Gene_expression denotes positive
T9624 19415-19422 Negative_regulation denotes absence
T9625 19432-19442 Gene_expression denotes expression
T9626 19548-19556 Gene_expression denotes positive
T9627 17562-17567 Protein denotes IRF-4
T9628 19096-19101 Protein denotes IRF-4
T9629 19210-19215 Protein denotes IRF-4
T9630 19426-19431 Protein denotes IRF-4
T9631 19542-19547 Protein denotes IRF-4
T9632 19565-19570 Protein denotes IRF-4
T9633 19717-19722 Protein denotes IRF-4
T9634 17672-17677 Protein denotes IRF-4
T9635 18302-18307 Protein denotes IRF-4
T9636 18324-18329 Protein denotes IRF-4
T9637 18367-18372 Protein denotes IRF-4
T9638 18393-18398 Protein denotes IRF-4
T9639 18466-18471 Protein denotes IRF-4
T9640 18486-18491 Protein denotes IRF-4
T9641 18548-18553 Protein denotes IRF-4
T9642 18554-18568 Gene_expression denotes negative cells
T9643 18492-18506 Gene_expression denotes positive cells
T10135 20233-20242 Regulation denotes decreased
T10136 20270-20278 Gene_expression denotes positive
T10137 20380-20388 Gene_expression denotes positive
T10138 20438-20448 Regulation denotes abrogation
T10139 20479-20487 Gene_expression denotes negative
T10140 19781-19786 Protein denotes IRF-4
T10141 20243-20251 Entity denotes promoter
T10142 20452-20460 Entity denotes promoter
T10143 20535-20546 Regulation denotes methylation
T10144 19905-19910 Protein denotes IRF-4
T10145 19968-19973 Protein denotes IRF-4
T10146 20204-20209 Protein denotes IRF-4
T10147 20264-20269 Protein denotes IRF-4
T10148 20374-20379 Protein denotes IRF-4
T10149 20473-20478 Protein denotes IRF-4
T10150 20598-20602 Protein denotes FasL
T10151 20767-20772 Protein denotes IRF-4
T10828 20967-20977 Regulation denotes regulation
T10829 21309-21317 Gene_expression denotes negative
T10830 21386-21397 Transcription denotes mRNA levels
T10831 21386-21397 Transcription denotes mRNA levels
T10832 21386-21397 Transcription denotes mRNA levels
T10833 21386-21397 Transcription denotes mRNA levels
T10834 21386-21397 Transcription denotes mRNA levels
T10835 21386-21397 Transcription denotes mRNA levels
T10836 21386-21397 Transcription denotes mRNA levels
T10837 21443-21453 Transcription denotes expression
T10838 21443-21453 Transcription denotes expression
T10839 21443-21453 Transcription denotes expression
T10840 21443-21453 Transcription denotes expression
T10841 21443-21453 Transcription denotes expression
T10842 21443-21453 Transcription denotes expression
T10843 21443-21453 Transcription denotes expression
T10844 21573-21581 Gene_expression denotes positive
T10845 21587-21595 Gene_expression denotes negative
T10846 21647-21660 Transcription denotes transcription
T10847 21647-21660 Transcription denotes transcription
T10848 21647-21660 Transcription denotes transcription
T10849 21647-21660 Transcription denotes transcription
T10850 21647-21660 Transcription denotes transcription
T10851 21647-21660 Transcription denotes transcription
T10852 21647-21660 Transcription denotes transcription
T10853 21295-21303 Gene_expression denotes positive
T10854 20885-20890 Protein denotes IRF-4
T10855 21289-21294 Protein denotes IRF-4
T10856 21479-21484 Protein denotes IRF-4
T10857 21567-21572 Protein denotes IRF-4
T10858 20958-20966 Entity denotes promoter
T10859 21123-21128 Protein denotes IRF-4
T10860 21204-21209 Protein denotes DNMT1
T10861 21211-21217 Protein denotes DNMT3A
T10862 21222-21228 Protein denotes DNMT3B
T10863 21238-21242 Protein denotes MBD1
T10864 21244-21248 Protein denotes MBD2
T10865 21250-21254 Protein denotes MBD4
T10866 21259-21263 Protein denotes MeCP
T10867 21270-21280 Gene_expression denotes expression
T10868 21270-21280 Gene_expression denotes expression
T10869 21270-21280 Gene_expression denotes expression
T10870 21270-21280 Gene_expression denotes expression
T10871 21270-21280 Gene_expression denotes expression
T10872 21270-21280 Gene_expression denotes expression
T14439 21976-21982 Negative_regulation denotes absent
T14440 22538-22546 Gene_expression denotes negative
T14441 22551-22559 Gene_expression denotes positive
T14442 22630-22636 Regulation denotes change
T14443 22715-22721 Regulation denotes affect
T14444 22715-22721 Regulation denotes affect
T14445 22969-22979 Gene_expression denotes expression
T14446 23009-23016 Positive_regulation denotes induced
T14447 23194-23209 Negative_regulation denotes down-regulation
T14448 23219-23229 Gene_expression denotes expression
T14449 23261-23264 Positive_regulation denotes due
T14450 21989-21999 Gene_expression denotes expression
T14451 23337-23350 Gene_expression denotes re-expression
T14452 23390-23396 Positive_regulation denotes result
T14453 23612-23623 Binding denotes interacting
T14454 23695-23705 Regulation denotes regulation
T14455 23715-23725 Gene_expression denotes expression
T14456 23865-23875 Gene_expression denotes expression
T14457 24056-24063 Positive_regulation denotes account
T14458 24072-24079 Negative_regulation denotes absence
T14459 24089-24099 Gene_expression denotes expression
T14460 24319-24327 Gene_expression denotes positive
T14461 22160-22164 Negative_regulation denotes lack
T14462 24461-24465 Regulation denotes role
T14463 24469-24479 Regulation denotes regulation
T14464 24489-24499 Gene_expression denotes expression
T14465 24546-24560 Regulation denotes important role
T14466 24570-24579 Positive_regulation denotes induction
T14467 24589-24599 Gene_expression denotes expression
T14468 24600-24607 Positive_regulation denotes depends
T14469 24611-24618 Binding denotes binding
T14470 24760-24768 Negative_regulation denotes inhibits
T14471 24769-24776 Binding denotes binding
T14472 22174-22184 Gene_expression denotes expression
T14473 24889-24897 Gene_expression denotes positive
T14474 24903-24911 Gene_expression denotes negative
T14475 24998-25007 Negative_regulation denotes silencing
T14476 25096-25108 Regulation denotes deregulation
T14477 25292-25306 Positive_regulation denotes overexpression
T14478 25647-25657 Gene_expression denotes expression
T14479 25898-25908 Gene_expression denotes expression
T14480 25963-25973 Gene_expression denotes expression
T14481 26085-26089 Negative_regulation denotes loss
T14482 26099-26109 Gene_expression denotes expression
T14483 22345-22356 Positive_regulation denotes responsible
T14484 26315-26325 Gene_expression denotes expression
T14485 26399-26407 Negative_regulation denotes impaired
T14486 26486-26490 Negative_regulation denotes loss
T14487 26516-26524 Negative_regulation denotes reverted
T14488 26534-26542 Gene_expression denotes negative
T14489 26640-26646 Regulation denotes effect
T14490 26656-26662 Gene_expression denotes levels
T14491 26672-26680 Gene_expression denotes positive
T14492 26948-26958 Gene_expression denotes expression
T14493 26959-26966 Regulation denotes changes
T14494 22361-22367 Negative_regulation denotes absent
T14495 27388-27397 Positive_regulation denotes resulting
T14496 27414-27428 Positive_regulation denotes overexpression
T14497 27475-27485 Gene_expression denotes expression
T14498 27737-27752 Negative_regulation denotes Down-regulation
T14499 27875-27884 Gene_expression denotes knock-out
T14500 27875-27884 Gene_expression denotes knock-out
T14501 27908-27921 Positive_regulation denotes up-regulation
T14502 28042-28051 Regulation denotes regulates
T14503 28058-28068 Gene_expression denotes expression
T14504 28088-28098 Gene_expression denotes expression
T14505 22374-22384 Gene_expression denotes expression
T14506 28146-28157 Positive_regulation denotes consequence
T14507 22440-22448 Gene_expression denotes positive
T14508 22454-22462 Gene_expression denotes negative
T14509 21983-21988 Protein denotes IRF-4
T14510 23213-23218 Protein denotes IRF-4
T14511 24736-24739 Entity denotes CpG
T14512 24747-24759 Entity denotes NFκB element
T14513 23453-23458 Protein denotes IRF-4
T14514 25021-25029 Entity denotes promoter
T14515 23579-23584 Protein denotes IRF-7
T14516 23598-23602 Protein denotes PU.1
T14517 23635-23640 Protein denotes IRF-4
T14518 23709-23714 Protein denotes IRF-4
T14519 23859-23864 Protein denotes IRF-4
T14520 23958-23963 Protein denotes IRF-4
T14521 24083-24088 Protein denotes IRF-4
T14522 24313-24318 Protein denotes IRF-4
T14523 22118-22123 Protein denotes IRF-4
T14524 24351-24356 Protein denotes IRF-4
T14525 24483-24488 Protein denotes IRF-4
T14526 24564-24569 Protein denotes IRF-4
T14527 24583-24588 Protein denotes IRF-4
T14528 24641-24646 Protein denotes c-Rel
T14529 24672-24677 Protein denotes IRF-4
T14530 24883-24888 Protein denotes IRF-4
T14531 25015-25020 Protein denotes IRF-4
T14532 25090-25095 Protein denotes IRF-4
T14533 25310-25315 Protein denotes DNMT1
T14534 22168-22173 Protein denotes IRF-4
T14535 25641-25646 Protein denotes DNMT1
T14536 25689-25697 Protein denotes p15INK4b
T14537 25892-25897 Protein denotes IRF-4
T14538 25957-25962 Protein denotes IRF-4
T14539 26093-26098 Protein denotes IRF-4
T14540 26342-26380 Protein denotes IFN consensus sequence binding protein
T14541 26382-26387 Protein denotes ICSBP
T14542 26388-26393 Protein denotes IRF-8
T14543 26475-26480 Protein denotes IRF-4
T14544 26528-26533 Protein denotes ICSBP
T14545 22368-22373 Protein denotes IRF-4
T14546 26650-26655 Protein denotes ICSBP
T14547 26666-26671 Protein denotes ICSBP
T14548 26776-26781 Protein denotes IRF-4
T14549 26838-26846 Protein denotes p15INK4b
T14550 26848-26856 Protein denotes p16INK4a
T14551 26860-26863 Protein denotes p53
T14552 27082-27087 Protein denotes IRF-4
T14553 27144-27149 Protein denotes IRF-4
T14554 27192-27197 Protein denotes IRF-4
T14555 27345-27371 Protein denotes immunoglobulin heavy-chain
T14556 22434-22439 Protein denotes IRF-4
T14557 27373-27376 Protein denotes IgH
T14558 27382-27387 Protein denotes IRF-4
T14559 27432-27437 Protein denotes IRF-4
T14560 27469-27474 Protein denotes IRF-4
T14561 27730-27735 Protein denotes IRF-4
T14562 27756-27761 Protein denotes IRF-4
T14563 27850-27855 Protein denotes IRF-4
T14564 27859-27864 Protein denotes ICSBP
T14565 27902-27907 Protein denotes IRF-4
T14566 28015-28020 Protein denotes IRF-4
T14567 22532-22537 Protein denotes IRF-4
T14568 28052-28057 Protein denotes IRF-4
T14569 28102-28107 Protein denotes IRF-4
T14570 28161-28166 Protein denotes IRF-4
T14571 22833-22838 Protein denotes IRF-4
T14572 22656-22690 Entity denotes transcription factor binding sites
T14573 22726-22743 Entity denotes restriction sites
T14574 22963-22968 Protein denotes IRF-4
T14575 22747-22767 Entity denotes primer binding sites
T14576 23049-23054 Protein denotes IFN-α
T14577 24524-24537 Entity denotes NFκB elements
R630 T869 T870 themeOf interferon regulatory factor 4,expression
R631 T870 T868 themeOf expression,Down-regulation
R632 T874 T873 themeOf interferon regulatory factor 4,deregulation
R633 T875 T874 equivalentTo IRF-4,interferon regulatory factor 4
R634 T878 T879 themeOf IRF-4,expression
R635 T879 T877 themeOf expression,regulation
R636 T881 T882 themeOf IRF-4,expression
R637 T882 T880 themeOf expression,altered
R638 T885 T886 themeOf IRF-4,transcription
R639 T886 T884 themeOf transcription,influence
R640 T887 T888 themeOf IRF-4,negative
R641 T890 T889 themeOf increase,resulted
R642 T891 T890 themeOf IRF-4,increase
R643 T892 T893 themeOf IRF-4,negative
R644 T894 T895 themeOf IRF-4,positive
R645 T896 T897 themeOf IRF-4,down-regulation
R646 T900 T901 themeOf IRF-4,expression
R647 T901 T899 themeOf expression,down-regulated
R2074 T2654 T2653 themeOf expression,regulate
R2075 T2656 T2655 themeOf expression,regulate
R2076 T2657 T2658 themeOf expression,silencing
R2079 T2661 T2650 themeOf expression,leading
R2081 T2663 T2662 themeOf expression,impaired
R2083 T2667 T2668 themeOf expression,induced
R2085 T2669 T2661 themeOf bcr-abl fusion gene,expression
R2087 T2670 T2698 equivalentTo Pip,IRF-4
R2088 T2671 T2698 equivalentTo MUM1,IRF-4
R2089 T2672 T2698 equivalentTo LSIRF,IRF-4
R2091 T2673 T2666 themeOf IRF-4,positive
R2092 T2674 T2667 themeOf IRF-4,expression
R2093 T2675 T2651 themeOf IRF-4,deletion
R2095 T2676 T2652 themeOf IRF-4,expression
R2101 T2687 T2654 themeOf c-abl,expression
R2102 T2688 T2656 themeOf bcr,expression
R2105 T2690 T2657 themeOf IRF-4,expression
R2110 T2691 T2680 equivalentTo IFN-α,interferon α
R2111 T2693 T2659 themeOf IRF-4,positive
R2112 T2693 T2660 themeOf IRF-4,negative
R2113 T2694 T2663 themeOf interferon regulatory factor 4,expression
R2115 T2695 T2694 equivalentTo IRF-4,interferon regulatory factor 4
R2117 T2697 T2664 themeOf IRF-4,silencing
R2118 T2698 T2665 themeOf IRF-4,expression
R2120 T2699 T2698 equivalentTo ICSAT,IRF-4
R2262 T2853 T2852 themeOf IRF-4,negative
R3510 T4330 T4319 themeOf IRF-4,transcriptional
R3511 T4331 T4320 themeOf MBD4,expression
R3512 T4332 T4321 themeOf IRF-4,expression
R3513 T4334 T4333 equivalentTo ICSAT,IRF-4
R3514 T4335 T4333 equivalentTo M-17,IRF-4
R3515 T4337 T4322 themeOf IRF-4,RNA expression
R3516 T4338 T4323 themeOf β-actin,RNA expression
R3517 T4339 T4324 themeOf DNMT1,expression
R3518 T4340 T4325 themeOf DNMT3A,expression
R3519 T4341 T4326 themeOf DNMT3B,expression
R3520 T4342 T4327 themeOf MeCP,expression
R3521 T4343 T4328 themeOf MBD1,expression
R3522 T4344 T4329 themeOf MBD2,expression
R5119 T6117 T6115 themeOf promoter,activation
R5120 T6117 T6121 partOf promoter,IRF-4
R5121 T6119 T6113 themeOf luciferase,expressing
R5122 T6119 T6114 themeOf luciferase,expressed
R5743 T6887 T6895 themeOf Absence,due
R5744 T6891 T6890 themeOf expression,absence
R5745 T6894 T6887 themeOf expression,Absence
R5746 T6897 T6896 themeOf expression,lack
R5747 T6902 T6894 themeOf IRF-4,expression
R5748 T6903 T6891 themeOf IRF-4,expression
R5749 T6904 T6892 themeOf IRF-4,positive
R5750 T6905 T6893 themeOf IRF-4,negative
R5751 T6906 T6897 themeOf IRF-4,expression
R5752 T6907 T6898 themeOf IRF-4,expression
R5753 T6908 T6899 themeOf bcr-abl,positive
R5754 T6909 T6900 themeOf bcr-abl,positve
R5755 T6910 T6901 themeOf bcr-abl,positve
R5756 T6911 T6888 themeOf bcr-abl,positive
R5757 T6912 T6889 themeOf bcr-abl,positive
R6465 T7766 T7765 themeOf expression,effect
R6466 T7768 T7767 themeOf mRNA level,increased
R6467 T7770 T7769 themeOf expression,control
R6468 T7773 T7772 themeOf transcription,activation
R6469 T7774 T7775 themeOf transcription,induced
R6470 T7774 T7776 themeOf transcription,increased
R6471 T7778 T7768 themeOf IRF-4,mRNA level
R6472 T7779 T7770 themeOf IRF-4,expression
R6473 T7781 T7771 themeOf IRF-4,expression
R6474 T7783 T7773 themeOf IRF-4,transcription
R6475 T7784 T7774 themeOf IRF-4,transcription
R6476 T7785 T7777 themeOf IRF-4,transcripts
R6477 T7787 T7764 themeOf IRF-4,positive
R6478 T7788 T7766 themeOf IRF-4,expression
R7043 T8471 T8464 themeOf IRF-4,expression
R7044 T8473 T8465 themeOf IRF-4,negative
R7045 T8476 T8468 themeOf IRF-4,transcription
R8013 T9620 T9619 themeOf expression,regulation
R8014 T9625 T9624 themeOf expression,absence
R8015 T9628 T9622 themeOf IRF-4,negative
R8016 T9629 T9623 themeOf IRF-4,positive
R8017 T9630 T9625 themeOf IRF-4,expression
R8018 T9631 T9626 themeOf IRF-4,positive
R8019 T9632 T9618 themeOf IRF-4,negative
R8020 T9633 T9620 themeOf IRF-4,expression
R8021 T9636 T9617 themeOf IRF-4,positive
R8022 T9638 T9621 themeOf IRF-4,negative
R8023 T9640 T9643 themeOf IRF-4,positive cells
R8024 T9641 T9642 themeOf IRF-4,negative cells
R8404 T10141 T10135 themeOf promoter,decreased
R8405 T10141 T10146 partOf promoter,IRF-4
R8406 T10142 T10138 themeOf promoter,abrogation
R8407 T10142 T10149 partOf promoter,IRF-4
R8408 T10147 T10136 themeOf IRF-4,positive
R8409 T10148 T10137 themeOf IRF-4,positive
R8410 T10149 T10139 themeOf IRF-4,negative
R8411 T10150 T10143 themeOf FasL,methylation
R8956 T10855 T10853 themeOf IRF-4,positive
R8957 T10855 T10829 themeOf IRF-4,negative
R8958 T10857 T10844 themeOf IRF-4,positive
R8959 T10857 T10845 themeOf IRF-4,negative
R8960 T10858 T10828 themeOf promoter,regulation
R8961 T10858 T10859 partOf promoter,IRF-4
R8962 T10860 T10830 themeOf DNMT1,mRNA levels
R8963 T10860 T10837 themeOf DNMT1,expression
R8964 T10860 T10846 themeOf DNMT1,transcription
R8965 T10860 T10867 themeOf DNMT1,expression
R8966 T10861 T10831 themeOf DNMT3A,mRNA levels
R8967 T10861 T10838 themeOf DNMT3A,expression
R8968 T10861 T10847 themeOf DNMT3A,transcription
R8969 T10861 T10868 themeOf DNMT3A,expression
R8970 T10862 T10832 themeOf DNMT3B,mRNA levels
R8971 T10862 T10839 themeOf DNMT3B,expression
R8972 T10862 T10848 themeOf DNMT3B,transcription
R8973 T10862 T10869 themeOf DNMT3B,expression
R8974 T10863 T10833 themeOf MBD1,mRNA levels
R8975 T10863 T10840 themeOf MBD1,expression
R8976 T10863 T10849 themeOf MBD1,transcription
R8977 T10863 T10870 themeOf MBD1,expression
R8978 T10864 T10834 themeOf MBD2,mRNA levels
R8979 T10864 T10841 themeOf MBD2,expression
R8980 T10864 T10850 themeOf MBD2,transcription
R8981 T10864 T10871 themeOf MBD2,expression
R8982 T10865 T10835 themeOf MBD4,mRNA levels
R8983 T10865 T10842 themeOf MBD4,expression
R8984 T10865 T10851 themeOf MBD4,transcription
R8985 T10866 T10836 themeOf MeCP,mRNA levels
R8986 T10866 T10843 themeOf MeCP,expression
R8987 T10866 T10852 themeOf MeCP,transcription
R8988 T10866 T10872 themeOf MeCP,expression
R11906 T14445 T14446 themeOf expression,induced
R11907 T14447 T14449 themeOf down-regulation,due
R11908 T14448 T14447 themeOf expression,down-regulation
R11909 T14450 T14439 themeOf expression,absent
R11910 T14451 T14452 themeOf re-expression,result
R11912 T14455 T14454 themeOf expression,regulation
R11913 T14458 T14457 themeOf absence,account
R11914 T14459 T14458 themeOf expression,absence
R11915 T14463 T14462 themeOf regulation,role
R11917 T14464 T14463 themeOf expression,regulation
R11918 T14466 T14465 themeOf induction,important role
R11920 T14467 T14468 themeOf expression,depends
R11921 T14469 T14468 causeOf binding,depends
R11923 T14471 T14470 themeOf binding,inhibits
R11926 T14472 T14461 themeOf expression,lack
R11929 T14482 T14481 themeOf expression,loss
R11930 T14484 T14485 themeOf expression,impaired
R11932 T14486 T14487 themeOf loss,reverted
R11933 T14516 T14453 themeOf PU.1,interacting
R11934 T14490 T14489 themeOf levels,effect
R11935 T14492 T14493 themeOf expression,changes
R11936 T14494 T14483 themeOf absent,responsible
R11937 T14517 T14453 themeOf IRF-4,interacting
R11938 T14496 T14495 themeOf overexpression,resulting
R11939 T14518 T14455 themeOf IRF-4,expression
R11940 T14519 T14456 themeOf IRF-4,expression
R11941 T14503 T14502 themeOf expression,regulates
R11942 T14521 T14459 themeOf IRF-4,expression
R11943 T14504 T14506 themeOf expression,consequence
R11944 T14505 T14494 themeOf expression,absent
R11945 T14522 T14460 themeOf IRF-4,positive
R11946 T14509 T14450 themeOf IRF-4,expression
R11947 T14525 T14464 themeOf IRF-4,expression
R11948 T14526 T14466 themeOf IRF-4,induction
R11949 T14527 T14467 themeOf IRF-4,expression
R11950 T14510 T14448 themeOf IRF-4,expression
R11951 T14510 T14451 themeOf IRF-4,re-expression
R11952 T14511 T14470 causeOf CpG,inhibits
R11953 T14511 T14529 partOf CpG,IRF-4
R11954 T14528 T14469 themeOf c-Rel,binding
R11955 T14512 T14471 themeOf NFκB element,binding
R11956 T14512 T14529 partOf NFκB element,IRF-4
R11957 T14514 T14475 themeOf promoter,silencing
R11958 T14514 T14531 partOf promoter,IRF-4
R11959 T14530 T14473 themeOf IRF-4,positive
R11960 T14530 T14474 themeOf IRF-4,negative
R11961 T14532 T14476 themeOf IRF-4,deregulation
R11962 T14545 T14505 themeOf IRF-4,expression
R11963 T14546 T14490 themeOf ICSBP,levels
R11964 T14533 T14477 themeOf DNMT1,overexpression
R11965 T14547 T14491 themeOf ICSBP,positive
R11966 T14548 T14492 themeOf IRF-4,expression
R11967 T14534 T14472 themeOf IRF-4,expression
R11968 T14535 T14478 themeOf DNMT1,expression
R11969 T14537 T14479 themeOf IRF-4,expression
R11970 T14556 T14507 themeOf IRF-4,positive
R11971 T14556 T14508 themeOf IRF-4,negative
R11972 T14557 T14555 equivalentTo IgH,immunoglobulin heavy-chain
R11973 T14538 T14480 themeOf IRF-4,expression
R11974 T14559 T14496 themeOf IRF-4,overexpression
R11975 T14560 T14497 themeOf IRF-4,expression
R11976 T14539 T14482 themeOf IRF-4,expression
R11977 T14562 T14498 themeOf IRF-4,Down-regulation
R11978 T14540 T14484 themeOf IFN consensus sequence binding protein,expression
R11979 T14563 T14499 themeOf IRF-4,knock-out
R11980 T14564 T14500 themeOf ICSBP,knock-out
R11981 T14565 T14501 themeOf IRF-4,up-regulation
R11982 T14567 T14440 themeOf IRF-4,negative
R11983 T14567 T14441 themeOf IRF-4,positive
R11984 T14568 T14503 themeOf IRF-4,expression
R11985 T14540 T14486 themeOf IFN consensus sequence binding protein,loss
R11986 T14569 T14504 themeOf IRF-4,expression
R11987 T14541 T14540 equivalentTo ICSBP,IFN consensus sequence binding protein
R11988 T14572 T14442 themeOf transcription factor binding sites,change
R11989 T14572 T14545 partOf transcription factor binding sites,IRF-4
R11990 T14573 T14545 partOf restriction sites,IRF-4
R11991 T14573 T14444 themeOf restriction sites,affect
R11992 T14542 T14540 equivalentTo IRF-8,IFN consensus sequence binding protein
R11993 T14574 T14445 themeOf IRF-4,expression
R11994 T14575 T14545 partOf primer binding sites,IRF-4
R11995 T14575 T14443 themeOf primer binding sites,affect
R11996 T14576 T14446 causeOf IFN-α,induced
R11997 T14544 T14488 themeOf ICSBP,negative
R11998 T14577 T14465 causeOf NFκB elements,important role
R11999 T14577 T14529 partOf NFκB elements,IRF-4
R12000 T14577 T14469 themeOf NFκB elements,binding

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T811 410-415 Protein denotes IRF-4
T812 669-674 Protein denotes IRF-4
T813 731-741 Regulation denotes regulation true
T814 745-750 Protein denotes IRF-4
T815 751-761 Gene_expression denotes expression
T816 869-876 Regulation denotes altered
T817 877-882 Protein denotes IRF-4
T818 883-893 Gene_expression denotes expression
T819 922-927 Protein denotes IRF-4
T820 983-992 Regulation denotes influence
T821 993-998 Protein denotes IRF-4
T822 999-1012 Transcription denotes transcription
T823 1034-1039 Protein denotes IRF-4
T824 1040-1048 Gene_expression denotes negative true
T825 1145-1153 Positive_regulation denotes resulted
T826 1193-1201 Positive_regulation denotes increase
T827 1205-1210 Protein denotes IRF-4
T828 1350-1355 Protein denotes IRF-4
T829 1356-1364 Gene_expression denotes negative true
T830 1376-1381 Protein denotes IRF-4
T831 1382-1390 Gene_expression denotes positive
T832 1467-1472 Protein denotes IRF-4
T833 1473-1488 Negative_regulation denotes down-regulation
T834 1698-1703 Protein denotes IRF-4
T835 1752-1766 Negative_regulation denotes down-regulated true
T836 1767-1772 Protein denotes IRF-4
T837 1773-1783 Gene_expression denotes expression
T2515 2172-2179 Positive_regulation denotes leading
T2516 2183-2193 Gene_expression denotes expression
T2517 2199-2218 Protein denotes bcr-abl fusion gene
T2518 2278-2290 Protein denotes interferon α
T2519 2292-2297 Protein denotes IFN-α
T2520 2446-2454 Negative_regulation denotes impaired
T2521 2455-2465 Gene_expression denotes expression
T2522 2473-2503 Protein denotes interferon regulatory factor 4
T2523 2505-2510 Protein denotes IRF-4
T2524 2554-2559 Protein denotes IFN-α
T2525 2592-2601 Negative_regulation denotes silencing
T2526 2605-2610 Protein denotes IRF-4
T2527 2938-2943 Protein denotes IRF-4
T2528 2945-2950 Protein denotes ICSAT
T2529 2951-2954 Protein denotes Pip
T2530 2955-2959 Protein denotes MUM1
T2531 2960-2965 Protein denotes LSIRF
T2532 3002-3012 Gene_expression denotes expression
T2533 3071-3076 Protein denotes IRF-4
T2534 3077-3085 Gene_expression denotes positive
T2535 3121-3131 Gene_expression denotes expression
T2536 3135-3140 Protein denotes IRF-4
T2537 3151-3158 Positive_regulation denotes induced true
T2538 3355-3363 Negative_regulation denotes deletion
T2539 3367-3372 Protein denotes IRF-4
T2540 3466-3476 Gene_expression denotes expression
T2541 3480-3485 Protein denotes IRF-4
T2542 3571-3576 Protein denotes IRF-4
T2543 4167-4171 Protein denotes MGMT
T2544 4173-4177 Protein denotes DAPK
T2545 4179-4185 Protein denotes p14ARF
T2546 4187-4195 Protein denotes p15INK4b
T2547 4197-4205 Protein denotes p16INK4a
T2548 4207-4212 Protein denotes BRCA1
T2549 4214-4219 Protein denotes CDH13
T2550 4224-4230 Protein denotes APAF-1
T2551 4272-4280 Regulation denotes regulate
T2552 4272-4280 Regulation denotes regulate
T2553 4281-4291 Gene_expression denotes expression
T2554 4281-4291 Gene_expression denotes expression
T2555 4299-4304 Protein denotes c-abl
T2556 4310-4313 Protein denotes bcr
T2557 4376-4381 Protein denotes c-abl
T2558 4937-4942 Protein denotes IRF-4
T2559 4948-4958 Gene_expression denotes expression
T2560 4959-4968 Negative_regulation denotes silencing
T2561 5004-5009 Protein denotes IRF-4
T2562 5078-5083 Protein denotes IRF-4
T2563 5084-5092 Gene_expression denotes positive
T2564 5098-5106 Gene_expression denotes negative true
T2850 5476-5481 Protein denotes IRF-4
T2851 5482-5490 Gene_expression denotes negative true
T3356 5991-5996 Protein denotes IRF-4
T3357 6026-6031 Protein denotes IRF-4
T4269 6845-6850 Protein denotes IRF-4
T4270 6851-6866 Transcription denotes transcriptional
T4271 7052-7066 Transcription denotes RNA expression
T4272 7052-7066 Transcription denotes RNA expression
T4273 7080-7085 Protein denotes IRF-4
T4274 7109-7116 Protein denotes β-actin
T4275 7273-7283 Gene_expression denotes expression true
T4276 7273-7283 Gene_expression denotes expression true
T4277 7273-7283 Gene_expression denotes expression true
T4278 7273-7283 Gene_expression denotes expression true
T4279 7273-7283 Gene_expression denotes expression true
T4280 7273-7283 Gene_expression denotes expression true
T4281 7273-7283 Gene_expression denotes expression true
T4282 7309-7314 Protein denotes DNMT1
T4283 7315-7321 Protein denotes DNMT3A
T4284 7323-7329 Protein denotes DNMT3B
T4285 7331-7335 Protein denotes MeCP
T4286 7337-7341 Protein denotes MBD1
T4287 7343-7347 Protein denotes MBD2
T4288 7352-7356 Protein denotes MBD4
T4289 7405-7410 Protein denotes IRF-4
T4290 7419-7429 Gene_expression denotes expression true
T4291 8615-8620 Protein denotes IRF-4
T4292 8621-8626 Protein denotes ICSAT
T4293 8628-8632 Protein denotes M-17
T4294 8692-8699 Protein denotes β-actin
T4922 9440-9445 Protein denotes IRF-4
T5648 11328-11333 Protein denotes IRF-4
T6091 12107-12112 Protein denotes IRF-4
T6092 12231-12244 Protein denotes CpG Methylase
T6093 12246-12253 Protein denotes M.Sss I
T6094 12414-12424 Protein denotes luciferase
T6095 12569-12579 Gene_expression denotes expressing
T6096 12592-12602 Protein denotes luciferase
T6097 12627-12636 Gene_expression denotes expressed
T6098 12779-12789 Protein denotes luciferase
T6099 12877-12882 Protein denotes IRF-4
T6100 12883-12891 Entity denotes promoter
T6101 12892-12902 Positive_regulation denotes activation
T6817 13058-13065 Negative_regulation denotes Absence
T6818 13069-13074 Protein denotes IRF-4
T6819 13075-13085 Gene_expression denotes expression
T6820 13111-13114 Positive_regulation denotes due true
T6821 13173-13177 Negative_regulation denotes lack
T6822 13181-13186 Protein denotes IRF-4
T6823 13187-13197 Gene_expression denotes expression
T6824 13292-13297 Protein denotes IRF-4
T6825 13298-13308 Gene_expression denotes expression true
T6826 13391-13398 Protein denotes bcr-abl
T6827 13399-13407 Gene_expression denotes positive
T6828 13430-13437 Protein denotes bcr-abl
T6829 13438-13445 Gene_expression denotes positve
T6830 13510-13517 Protein denotes bcr-abl
T6831 13518-13525 Gene_expression denotes positve
T6832 13563-13570 Protein denotes bcr-abl
T6833 13571-13579 Gene_expression denotes positive
T6834 13666-13673 Protein denotes bcr-abl
T6835 13674-13682 Gene_expression denotes positive
T6836 13740-13745 Protein denotes IRF-4
T6837 13782-13789 Negative_regulation denotes absence
T6838 13793-13798 Protein denotes IRF-4
T6839 13799-13809 Gene_expression denotes expression
T6840 13964-13969 Protein denotes IRF-4
T6841 13970-13978 Gene_expression denotes positive
T6842 13994-13999 Protein denotes IRF-4
T6843 14000-14008 Gene_expression denotes negative true
T6844 14300-14306 Regulation denotes affect true true
T6845 14307-14312 Protein denotes IRF-4
T6846 14313-14323 Gene_expression denotes expression
T7704 14326-14334 Positive_regulation denotes Increase
T7705 14338-14343 Protein denotes IRF-4
T7706 14344-14354 Gene_expression denotes expression
T7707 14498-14503 Protein denotes IRF-4
T7708 14504-14514 Gene_expression denotes expression
T7709 14548-14553 Protein denotes IRF-4
T7710 14925-14935 Positive_regulation denotes activation
T7711 14939-14944 Protein denotes IRF-4
T7712 14945-14958 Transcription denotes transcription
T7713 15048-15053 Protein denotes IRF-4
T7714 15054-15067 Transcription denotes transcription
T7715 15072-15079 Positive_regulation denotes induced
T7716 15172-15181 Positive_regulation denotes increased
T7717 15255-15260 Protein denotes IRF-4
T7718 15261-15272 Transcription denotes transcripts
T7719 15465-15470 Protein denotes IRF-4
T7720 15533-15538 Protein denotes IRF-4
T7721 15539-15547 Gene_expression denotes positive
T7722 15603-15609 Regulation denotes effect true
T7723 15613-15618 Protein denotes IRF-4
T7724 15619-15629 Gene_expression denotes expression
T7725 15712-15721 Positive_regulation denotes increased
T7726 15726-15731 Protein denotes IRF-4
T7727 15732-15742 Transcription denotes mRNA level
T7728 15828-15835 Regulation denotes control true
T7729 15836-15841 Protein denotes IRF-4
T7730 15842-15852 Gene_expression denotes expression
T7731 15945-15950 Protein denotes IRF-4
T9598 19723-19733 Gene_expression denotes expression
T10105 19781-19786 Protein denotes IRF-4
T10106 19905-19910 Protein denotes IRF-4
T10107 19968-19973 Protein denotes IRF-4
T10108 20204-20209 Protein denotes IRF-4
T10109 20233-20242 Negative_regulation denotes decreased
T10110 20243-20251 Entity denotes promoter
T10111 20264-20269 Protein denotes IRF-4
T10112 20270-20278 Gene_expression denotes positive
T10113 20374-20379 Protein denotes IRF-4
T10114 20380-20388 Gene_expression denotes positive
T10115 20438-20448 Negative_regulation denotes abrogation
T10116 20452-20460 Entity denotes promoter
T10117 20473-20478 Protein denotes IRF-4
T10118 20479-20487 Gene_expression denotes negative true
T10119 20598-20602 Protein denotes FasL
T10120 20767-20772 Protein denotes IRF-4
T10733 20885-20890 Protein denotes IRF-4
T10734 20958-20966 Entity denotes promoter
T10735 20967-20977 Regulation denotes regulation
T10736 21123-21128 Protein denotes IRF-4
T10737 21204-21209 Protein denotes DNMT1
T10738 21211-21217 Protein denotes DNMT3A
T10739 21222-21228 Protein denotes DNMT3B
T10740 21238-21242 Protein denotes MBD1
T10741 21244-21248 Protein denotes MBD2
T10742 21250-21254 Protein denotes MBD4
T10743 21259-21263 Protein denotes MeCP
T10744 21265-21280 Transcription denotes mRNA expression
T10745 21265-21280 Transcription denotes mRNA expression
T10746 21265-21280 Transcription denotes mRNA expression
T10747 21265-21280 Transcription denotes mRNA expression
T10748 21265-21280 Transcription denotes mRNA expression
T10749 21265-21280 Transcription denotes mRNA expression
T10750 21265-21280 Transcription denotes mRNA expression
T10751 21289-21294 Protein denotes IRF-4
T10752 21295-21303 Gene_expression denotes positive
T10753 21309-21317 Gene_expression denotes negative true
T10754 21386-21397 Transcription denotes mRNA levels
T10755 21386-21397 Transcription denotes mRNA levels
T10756 21386-21397 Transcription denotes mRNA levels
T10757 21386-21397 Transcription denotes mRNA levels
T10758 21386-21397 Transcription denotes mRNA levels
T10759 21386-21397 Transcription denotes mRNA levels
T10760 21386-21397 Transcription denotes mRNA levels
T10761 21443-21453 Transcription denotes expression
T10762 21443-21453 Transcription denotes expression
T10763 21443-21453 Transcription denotes expression
T10764 21443-21453 Transcription denotes expression
T10765 21443-21453 Transcription denotes expression
T10766 21443-21453 Transcription denotes expression
T10767 21443-21453 Transcription denotes expression
T10768 21479-21484 Protein denotes IRF-4
T10769 21567-21572 Protein denotes IRF-4
T10770 21573-21581 Gene_expression denotes positive
T10771 21587-21595 Gene_expression denotes negative true
T10772 21647-21660 Transcription denotes transcription
T10773 21647-21660 Transcription denotes transcription
T10774 21647-21660 Transcription denotes transcription
T10775 21647-21660 Transcription denotes transcription
T10776 21647-21660 Transcription denotes transcription
T10777 21647-21660 Transcription denotes transcription
T10778 21647-21660 Transcription denotes transcription
T14173 21976-21982 Negative_regulation denotes absent
T14174 21983-21988 Protein denotes IRF-4
T14175 21989-21999 Gene_expression denotes expression
T14176 22118-22123 Protein denotes IRF-4
T14177 22160-22164 Negative_regulation denotes lack
T14178 22168-22173 Protein denotes IRF-4
T14179 22174-22184 Gene_expression denotes expression
T14180 22345-22356 Positive_regulation denotes responsible true
T14181 22361-22367 Negative_regulation denotes absent
T14182 22368-22373 Protein denotes IRF-4
T14183 22374-22384 Gene_expression denotes expression
T14184 22434-22439 Protein denotes IRF-4
T14185 22440-22448 Gene_expression denotes positive
T14186 22454-22462 Gene_expression denotes negative true
T14187 22532-22537 Protein denotes IRF-4
T14188 22538-22546 Gene_expression denotes negative true
T14189 22551-22559 Gene_expression denotes positive
T14190 22630-22636 Regulation denotes change true
T14191 22656-22690 Entity denotes transcription factor binding sites
T14192 22715-22721 Regulation denotes affect true
T14193 22715-22721 Regulation denotes affect true
T14194 22726-22743 Entity denotes restriction sites
T14195 22747-22767 Entity denotes primer binding sites
T14196 22833-22838 Protein denotes IRF-4
T14197 22963-22968 Protein denotes IRF-4
T14198 22969-22979 Gene_expression denotes expression
T14199 23009-23016 Positive_regulation denotes induced
T14200 23049-23054 Protein denotes IFN-α
T14201 23194-23209 Negative_regulation denotes down-regulation
T14202 23213-23218 Protein denotes IRF-4
T14203 23219-23229 Gene_expression denotes expression
T14204 23261-23264 Positive_regulation denotes due true
T14205 23337-23350 Gene_expression denotes re-expression
T14206 23390-23396 Positive_regulation denotes result true
T14207 23453-23458 Protein denotes IRF-4
T14208 23579-23584 Protein denotes IRF-7
T14209 23598-23602 Protein denotes PU.1
T14210 23612-23623 Binding denotes interacting
T14211 23635-23640 Protein denotes IRF-4
T14212 23695-23705 Regulation denotes regulation
T14213 23709-23714 Protein denotes IRF-4
T14214 23715-23725 Gene_expression denotes expression
T14215 23859-23864 Protein denotes IRF-4
T14216 23865-23875 Gene_expression denotes expression
T14217 23958-23963 Protein denotes IRF-4
T14218 24056-24063 Positive_regulation denotes account true
T14219 24072-24079 Negative_regulation denotes absence
T14220 24083-24088 Protein denotes IRF-4
T14221 24089-24099 Gene_expression denotes expression
T14222 24313-24318 Protein denotes IRF-4
T14223 24319-24327 Gene_expression denotes positive
T14224 24351-24356 Protein denotes IRF-4
T14225 24461-24465 Regulation denotes role true
T14226 24469-24479 Regulation denotes regulation
T14227 24483-24488 Protein denotes IRF-4
T14228 24489-24499 Gene_expression denotes expression
T14229 24524-24537 Entity denotes NFκB elements
T14230 24546-24560 Regulation denotes important role
T14231 24564-24569 Protein denotes IRF-4
T14232 24570-24579 Positive_regulation denotes induction
T14233 24583-24588 Protein denotes IRF-4
T14234 24589-24599 Gene_expression denotes expression
T14235 24600-24607 Positive_regulation denotes depends
T14236 24611-24618 Binding denotes binding
T14237 24641-24646 Protein denotes c-Rel
T14238 24672-24677 Protein denotes IRF-4
T14239 24736-24739 Entity denotes CpG
T14240 24747-24759 Entity denotes NFκB element
T14241 24760-24768 Negative_regulation denotes inhibits
T14242 24769-24776 Binding denotes binding
T14243 24883-24888 Protein denotes IRF-4
T14244 24889-24897 Gene_expression denotes positive
T14245 24903-24911 Gene_expression denotes negative true
T14246 24998-25007 Negative_regulation denotes silencing
T14247 25015-25020 Protein denotes IRF-4
T14248 25021-25029 Entity denotes promoter
T14249 25090-25095 Protein denotes IRF-4
T14250 25096-25108 Regulation denotes deregulation true
T14251 25292-25306 Positive_regulation denotes overexpression
T14252 25310-25315 Protein denotes DNMT1
T14253 25641-25646 Protein denotes DNMT1
T14254 25647-25657 Gene_expression denotes expression
T14255 25689-25697 Protein denotes p15INK4b
T14256 25892-25897 Protein denotes IRF-4
T14257 25898-25908 Gene_expression denotes expression
T14258 25957-25962 Protein denotes IRF-4
T14259 25963-25973 Gene_expression denotes expression
T14260 26085-26089 Negative_regulation denotes loss
T14261 26093-26098 Protein denotes IRF-4
T14262 26099-26109 Gene_expression denotes expression
T14263 26315-26325 Gene_expression denotes expression
T14264 26342-26380 Protein denotes IFN consensus sequence binding protein
T14265 26382-26387 Protein denotes ICSBP
T14266 26388-26393 Protein denotes IRF-8
T14267 26399-26407 Negative_regulation denotes impaired
T14268 26475-26480 Protein denotes IRF-4
T14269 26486-26490 Negative_regulation denotes loss
T14270 26516-26524 Negative_regulation denotes reverted true
T14271 26528-26533 Protein denotes ICSBP
T14272 26534-26542 Gene_expression denotes negative true
T14273 26640-26646 Regulation denotes effect true
T14274 26650-26655 Protein denotes ICSBP
T14275 26656-26662 Gene_expression denotes levels
T14276 26666-26671 Protein denotes ICSBP
T14277 26672-26680 Gene_expression denotes positive
T14278 26776-26781 Protein denotes IRF-4
T14279 26838-26846 Protein denotes p15INK4b
T14280 26848-26856 Protein denotes p16INK4a
T14281 26860-26863 Protein denotes p53
T14282 26948-26958 Gene_expression denotes expression
T14283 26959-26966 Regulation denotes changes
T14284 27082-27087 Protein denotes IRF-4
T14285 27144-27149 Protein denotes IRF-4
T14286 27192-27197 Protein denotes IRF-4
T14287 27345-27371 Protein denotes immunoglobulin heavy-chain
T14288 27373-27376 Protein denotes IgH
T14289 27382-27387 Protein denotes IRF-4
T14290 27388-27397 Positive_regulation denotes resulting
T14291 27414-27428 Positive_regulation denotes overexpression
T14292 27432-27437 Protein denotes IRF-4
T14293 27469-27474 Protein denotes IRF-4
T14294 27475-27485 Gene_expression denotes expression
T14295 27730-27735 Protein denotes IRF-4
T14296 27737-27752 Negative_regulation denotes Down-regulation
T14297 27756-27761 Protein denotes IRF-4
T14298 27850-27855 Protein denotes IRF-4
T14299 27859-27864 Protein denotes ICSBP
T14300 27875-27884 Gene_expression denotes knock-out true
T14301 27875-27884 Gene_expression denotes knock-out true
T14302 27902-27907 Protein denotes IRF-4
T14303 27908-27921 Positive_regulation denotes up-regulation
T14304 28015-28020 Protein denotes IRF-4
T14305 28042-28051 Regulation denotes regulates true
T14306 28052-28057 Protein denotes IRF-4
T14307 28058-28068 Gene_expression denotes expression
T14308 28088-28098 Gene_expression denotes expression
T14309 28102-28107 Protein denotes IRF-4
T14310 28146-28157 Positive_regulation denotes consequence true
T14311 28161-28166 Protein denotes IRF-4
T804 0-15 Negative_regulation denotes Down-regulation
T805 19-49 Protein denotes interferon regulatory factor 4
T806 55-65 Gene_expression denotes expression
T807 169-172 Protein denotes bcr
T808 173-176 Protein denotes abl
T809 316-328 Regulation denotes deregulation true
T810 378-408 Protein denotes interferon regulatory factor 4
T8433 16035-16040 Protein denotes IRF-4
T8434 16146-16151 Protein denotes IRF-4
T8435 16157-16167 Gene_expression denotes expression
T8436 16539-16544 Protein denotes IRF-4
T8437 16828-16833 Protein denotes IRF-4
T8438 16834-16842 Gene_expression denotes negative true
T8439 17018-17023 Protein denotes IRF-4
T8440 17024-17032 Gene_expression denotes positive
T8441 17145-17150 Protein denotes IRF-4
T8442 17151-17159 Gene_expression denotes positive
T8443 17357-17362 Protein denotes IRF-4
T8444 17363-17376 Transcription denotes transcription
T8445 17513-17518 Protein denotes IRF-4
T8446 17519-17527 Gene_expression denotes negative true
T9572 17562-17567 Protein denotes IRF-4
T9573 17672-17677 Protein denotes IRF-4
T9574 18302-18307 Protein denotes IRF-4
T9575 18324-18329 Protein denotes IRF-4
T9576 18330-18338 Gene_expression denotes positive
T9577 18367-18372 Protein denotes IRF-4
T9578 18393-18398 Protein denotes IRF-4
T9579 18399-18407 Gene_expression denotes negative true
T9580 18466-18471 Protein denotes IRF-4
T9581 18486-18491 Protein denotes IRF-4
T9582 18492-18500 Gene_expression denotes positive
T9583 18548-18553 Protein denotes IRF-4
T9584 18554-18562 Gene_expression denotes negative true
T9585 19096-19101 Protein denotes IRF-4
T9586 19102-19110 Gene_expression denotes negative true
T9587 19210-19215 Protein denotes IRF-4
T9588 19216-19224 Gene_expression denotes positive
T9589 19415-19422 Negative_regulation denotes absence
T9590 19426-19431 Protein denotes IRF-4
T9591 19432-19442 Gene_expression denotes expression
T9592 19542-19547 Protein denotes IRF-4
T9593 19548-19556 Gene_expression denotes positive
T9594 19565-19570 Protein denotes IRF-4
T9595 19571-19579 Gene_expression denotes negative true
T9596 19703-19713 Regulation denotes regulation true
T9597 19717-19722 Protein denotes IRF-4
R2017 T2516 T2515 themeOf expression,leading
R2021 T2517 T2516 themeOf bcr-abl fusion gene,expression
R2024 T2519 T2518 equivalentTo IFN-α,interferon α
R2026 T2521 T2520 themeOf expression,impaired
R2029 T2522 T2521 themeOf interferon regulatory factor 4,expression
R2030 T2523 T2522 equivalentTo IRF-4,interferon regulatory factor 4
R2031 T2526 T2525 themeOf IRF-4,silencing
R2032 T2527 T2532 themeOf IRF-4,expression
R2033 T2528 T2527 equivalentTo ICSAT,IRF-4
R2034 T2529 T2527 equivalentTo Pip,IRF-4
R2035 T2530 T2527 equivalentTo MUM1,IRF-4
R2036 T2531 T2527 equivalentTo LSIRF,IRF-4
R2037 T2533 T2534 themeOf IRF-4,positive
R2038 T2553 T2552 themeOf expression,regulate
R2039 T2554 T2551 themeOf expression,regulate
R2040 T2535 T2537 themeOf expression,induced
R2041 T2555 T2553 themeOf c-abl,expression
R2042 T2556 T2554 themeOf bcr,expression
R2043 T2558 T2559 themeOf IRF-4,expression
R2044 T2536 T2535 themeOf IRF-4,expression
R2045 T2559 T2560 themeOf expression,silencing
R2046 T2539 T2538 themeOf IRF-4,deletion
R2047 T2562 T2563 themeOf IRF-4,positive
R2048 T2562 T2564 themeOf IRF-4,negative
R2049 T2541 T2540 themeOf IRF-4,expression
R2261 T2850 T2851 themeOf IRF-4,negative
R3488 T4269 T4270 themeOf IRF-4,transcriptional
R3489 T4273 T4271 themeOf IRF-4,RNA expression
R3490 T4274 T4272 themeOf β-actin,RNA expression
R3491 T4282 T4276 themeOf DNMT1,expression
R3492 T4283 T4277 themeOf DNMT3A,expression
R3493 T4284 T4278 themeOf DNMT3B,expression
R3494 T4285 T4279 themeOf MeCP,expression
R3495 T4286 T4280 themeOf MBD1,expression
R3496 T4287 T4281 themeOf MBD2,expression
R3497 T4288 T4275 themeOf MBD4,expression
R3498 T4289 T4290 themeOf IRF-4,expression
R3499 T4292 T4291 equivalentTo ICSAT,IRF-4
R3500 T4293 T4291 equivalentTo M-17,IRF-4
R5111 T6093 T6092 equivalentTo M.Sss I,CpG Methylase
R5112 T6096 T6095 themeOf luciferase,expressing
R5113 T6096 T6097 themeOf luciferase,expressed
R5114 T6100 T6101 themeOf promoter,activation
R5115 T6100 T6099 partOf promoter,IRF-4
R5705 T6817 T6820 themeOf Absence,due
R5706 T6818 T6819 themeOf IRF-4,expression
R5707 T6819 T6817 themeOf expression,Absence
R5708 T6822 T6823 themeOf IRF-4,expression
R5709 T6823 T6821 themeOf expression,lack
R5710 T6824 T6825 themeOf IRF-4,expression
R5711 T6826 T6827 themeOf bcr-abl,positive
R5712 T6828 T6829 themeOf bcr-abl,positve
R5713 T6830 T6831 themeOf bcr-abl,positve
R5714 T6832 T6833 themeOf bcr-abl,positive
R5715 T6834 T6835 themeOf bcr-abl,positive
R5716 T6838 T6839 themeOf IRF-4,expression
R5717 T6839 T6837 themeOf expression,absence
R5718 T6840 T6841 themeOf IRF-4,positive
R5719 T6842 T6843 themeOf IRF-4,negative
R5720 T6845 T6846 themeOf IRF-4,expression
R5721 T6846 T6844 themeOf expression,affect
R6438 T7714 T7715 themeOf transcription,induced
R6439 T7714 T7716 themeOf transcription,increased
R6440 T7717 T7718 themeOf IRF-4,transcripts
R7032 T8434 T8435 themeOf IRF-4,expression
R7033 T8437 T8438 themeOf IRF-4,negative
R7034 T8439 T8440 themeOf IRF-4,positive
R7035 T8441 T8442 themeOf IRF-4,positive
R7036 T8443 T8444 themeOf IRF-4,transcription
R7037 T8445 T8446 themeOf IRF-4,negative
R7996 T9575 T9576 themeOf IRF-4,positive
R7997 T9578 T9579 themeOf IRF-4,negative
R7998 T9581 T9582 themeOf IRF-4,positive
R7999 T9583 T9584 themeOf IRF-4,negative
R8000 T9585 T9586 themeOf IRF-4,negative
R8001 T9587 T9588 themeOf IRF-4,positive
R8002 T9590 T9591 themeOf IRF-4,expression
R8003 T9591 T9589 themeOf expression,absence
R8004 T9592 T9593 themeOf IRF-4,positive
R8005 T9594 T9595 themeOf IRF-4,negative
R8006 T9597 T9598 themeOf IRF-4,expression
R8007 T9598 T9596 themeOf expression,regulation
R8393 T10110 T10109 themeOf promoter,decreased
R8394 T10110 T10108 partOf promoter,IRF-4
R8395 T10111 T10112 themeOf IRF-4,positive
R8396 T10113 T10114 themeOf IRF-4,positive
R8397 T10116 T10115 themeOf promoter,abrogation
R8398 T10116 T10117 partOf promoter,IRF-4
R8399 T10117 T10118 themeOf IRF-4,negative
R8893 T10734 T10735 themeOf promoter,regulation
R8894 T10734 T10736 partOf promoter,IRF-4
R8895 T10737 T10747 themeOf DNMT1,mRNA expression
R8896 T10737 T10760 themeOf DNMT1,mRNA levels
R8897 T10737 T10763 themeOf DNMT1,expression
R8898 T10737 T10775 themeOf DNMT1,transcription
R8899 T10738 T10750 themeOf DNMT3A,mRNA expression
R8900 T10738 T10757 themeOf DNMT3A,mRNA levels
R8901 T10738 T10764 themeOf DNMT3A,expression
R8902 T10738 T10773 themeOf DNMT3A,transcription
R8903 T10739 T10749 themeOf DNMT3B,mRNA expression
R8904 T10739 T10758 themeOf DNMT3B,mRNA levels
R8905 T10739 T10767 themeOf DNMT3B,expression
R8906 T10739 T10774 themeOf DNMT3B,transcription
R8907 T10740 T10748 themeOf MBD1,mRNA expression
R8908 T10740 T10759 themeOf MBD1,mRNA levels
R8909 T10740 T10766 themeOf MBD1,expression
R8910 T10740 T10772 themeOf MBD1,transcription
R8911 T10741 T10745 themeOf MBD2,mRNA expression
R8912 T10741 T10756 themeOf MBD2,mRNA levels
R8913 T10741 T10765 themeOf MBD2,expression
R8914 T10741 T10776 themeOf MBD2,transcription
R8915 T10742 T10744 themeOf MBD4,mRNA expression
R8916 T10742 T10754 themeOf MBD4,mRNA levels
R8917 T10742 T10762 themeOf MBD4,expression
R8918 T10742 T10777 themeOf MBD4,transcription
R8919 T10743 T10746 themeOf MeCP,mRNA expression
R8920 T10743 T10755 themeOf MeCP,mRNA levels
R8921 T10743 T10761 themeOf MeCP,expression
R8922 T10743 T10778 themeOf MeCP,transcription
R8923 T10751 T10752 themeOf IRF-4,positive
R8924 T10751 T10753 themeOf IRF-4,negative
R8925 T10769 T10770 themeOf IRF-4,positive
R8926 T10769 T10771 themeOf IRF-4,negative
R11754 T14174 T14175 themeOf IRF-4,expression
R11756 T14175 T14173 themeOf expression,absent
R11757 T14178 T14179 themeOf IRF-4,expression
R11758 T14179 T14177 themeOf expression,lack
R11760 T14181 T14180 themeOf absent,responsible
R11761 T14182 T14183 themeOf IRF-4,expression
R11762 T14183 T14181 themeOf expression,absent
R11766 T14184 T14185 themeOf IRF-4,positive
R11767 T14184 T14186 themeOf IRF-4,negative
R11768 T14187 T14188 themeOf IRF-4,negative
R11769 T14187 T14189 themeOf IRF-4,positive
R11772 T14191 T14190 themeOf transcription factor binding sites,change
R11773 T14191 T14182 partOf transcription factor binding sites,IRF-4
R11775 T14194 T14192 themeOf restriction sites,affect
R11776 T14194 T14182 partOf restriction sites,IRF-4
R11777 T14195 T14193 themeOf primer binding sites,affect
R11778 T14195 T14182 partOf primer binding sites,IRF-4
R11779 T14197 T14198 themeOf IRF-4,expression
R11780 T14198 T14199 themeOf expression,induced
R11781 T14200 T14199 causeOf IFN-α,induced
R11782 T14201 T14204 themeOf down-regulation,due
R11783 T14202 T14203 themeOf IRF-4,expression
R11784 T14202 T14205 themeOf IRF-4,re-expression
R11786 T14203 T14201 themeOf expression,down-regulation
R11787 T14205 T14206 themeOf re-expression,result
R11789 T14209 T14210 themeOf PU.1,interacting
R11790 T14211 T14210 themeOf IRF-4,interacting
R11792 T14213 T14214 themeOf IRF-4,expression
R11794 T14214 T14212 themeOf expression,regulation
R11795 T14215 T14216 themeOf IRF-4,expression
R11796 T14264 T14263 themeOf IFN consensus sequence binding protein,expression
R11797 T14219 T14218 themeOf absence,account
R11798 T14220 T14221 themeOf IRF-4,expression
R11799 T14221 T14219 themeOf expression,absence
R11800 T14222 T14223 themeOf IRF-4,positive
R11801 T14264 T14269 themeOf IFN consensus sequence binding protein,loss
R11802 T14265 T14264 equivalentTo ICSBP,IFN consensus sequence binding protein
R11803 T14266 T14264 equivalentTo IRF-8,IFN consensus sequence binding protein
R11804 T14226 T14225 themeOf regulation,role
R11805 T14227 T14228 themeOf IRF-4,expression
R11806 T14228 T14226 themeOf expression,regulation
R11807 T14269 T14270 themeOf loss,reverted
R11808 T14229 T14230 causeOf NFκB elements,important role
R11809 T14229 T14238 partOf NFκB elements,IRF-4
R11810 T14229 T14236 themeOf NFκB elements,binding
R11811 T14231 T14232 themeOf IRF-4,induction
R11812 T14232 T14230 themeOf induction,important role
R11813 T14233 T14234 themeOf IRF-4,expression
R11814 T14234 T14235 themeOf expression,depends
R11815 T14271 T14272 themeOf ICSBP,negative
R11816 T14236 T14235 causeOf binding,depends
R11817 T14237 T14236 themeOf c-Rel,binding
R11818 T14274 T14275 themeOf ICSBP,levels
R11819 T14239 T14241 causeOf CpG,inhibits
R11820 T14239 T14238 partOf CpG,IRF-4
R11821 T14240 T14242 themeOf NFκB element,binding
R11822 T14240 T14238 partOf NFκB element,IRF-4
R11823 T14242 T14241 themeOf binding,inhibits
R11824 T14243 T14244 themeOf IRF-4,positive
R11825 T14243 T14245 themeOf IRF-4,negative
R11826 T14275 T14273 themeOf levels,effect
R11827 T14276 T14277 themeOf ICSBP,positive
R11828 T14248 T14246 themeOf promoter,silencing
R11829 T14248 T14247 partOf promoter,IRF-4
R11830 T14249 T14250 themeOf IRF-4,deregulation
R11831 T14252 T14251 themeOf DNMT1,overexpression
R11832 T14278 T14282 themeOf IRF-4,expression
R11833 T14253 T14254 themeOf DNMT1,expression
R11834 T14256 T14257 themeOf IRF-4,expression
R11835 T14282 T14283 themeOf expression,changes
R11836 T14258 T14259 themeOf IRF-4,expression
R11837 T14261 T14262 themeOf IRF-4,expression
R11838 T14262 T14260 themeOf expression,loss
R11839 T14263 T14267 themeOf expression,impaired
R11840 T14288 T14287 equivalentTo IgH,immunoglobulin heavy-chain
R11841 T14291 T14290 themeOf overexpression,resulting
R11842 T14292 T14291 themeOf IRF-4,overexpression
R11843 T14293 T14294 themeOf IRF-4,expression
R11844 T14297 T14296 themeOf IRF-4,Down-regulation
R11845 T14298 T14301 themeOf IRF-4,knock-out
R11846 T14299 T14300 themeOf ICSBP,knock-out
R11848 T14302 T14303 themeOf IRF-4,up-regulation
R11851 T14306 T14307 themeOf IRF-4,expression
R11855 T14307 T14305 themeOf expression,regulates
R11859 T14308 T14310 themeOf expression,consequence
R11861 T14309 T14308 themeOf IRF-4,expression
R600 T811 T810 equivalentTo IRF-4,interferon regulatory factor 4
R601 T814 T815 themeOf IRF-4,expression
R602 T815 T813 themeOf expression,regulation
R603 T817 T818 themeOf IRF-4,expression
R604 T818 T816 themeOf expression,altered
R605 T821 T822 themeOf IRF-4,transcription
R606 T822 T820 themeOf transcription,influence
R607 T823 T824 themeOf IRF-4,negative
R608 T826 T825 themeOf increase,resulted
R609 T827 T826 themeOf IRF-4,increase
R610 T828 T829 themeOf IRF-4,negative
R611 T830 T831 themeOf IRF-4,positive
R612 T832 T833 themeOf IRF-4,down-regulation
R613 T836 T837 themeOf IRF-4,expression
R614 T837 T835 themeOf expression,down-regulated
R692 T805 T806 themeOf interferon regulatory factor 4,expression
R693 T806 T804 themeOf expression,Down-regulation
R694 T810 T809 themeOf interferon regulatory factor 4,deregulation
R6432 T7705 T7706 themeOf IRF-4,expression
R6433 T7706 T7704 themeOf expression,Increase
R6434 T7707 T7708 themeOf IRF-4,expression
R6435 T7711 T7712 themeOf IRF-4,transcription
R6436 T7712 T7710 themeOf transcription,activation
R6437 T7713 T7714 themeOf IRF-4,transcription
R6441 T7720 T7721 themeOf IRF-4,positive
R6442 T7723 T7724 themeOf IRF-4,expression
R6443 T7724 T7722 themeOf expression,effect
R6444 T7726 T7727 themeOf IRF-4,mRNA level
R6445 T7727 T7725 themeOf mRNA level,increased
R6446 T7729 T7730 themeOf IRF-4,expression
R6447 T7730 T7728 themeOf expression,control

GO-CC

Id Subject Object Predicate Lexical cue
T701 1391-1396 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3349 6199-6203 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4186 8390-8398 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T4187 8589-8599 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T4188 8320-8328 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T4189 8390-8398 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T4190 8589-8599 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T6720 13098-13103 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6721 13245-13250 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6722 13334-13338 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6723 13366-13370 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6724 13410-13414 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6725 13685-13689 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6726 13830-13834 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T7616 14372-14377 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7617 14982-14987 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7618 15424-15429 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7619 15753-15758 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8387 17167-17172 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8388 17396-17401 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8389 17528-17533 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8390 17396-17415 http://purl.obolibrary.org/obo/GO_0009986 denotes cells is associated
T9481 17609-17614 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9482 17744-17749 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9483 17799-17804 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9484 18501-18506 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9485 18563-18568 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9486 18743-18748 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9487 18915-18920 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9488 19225-19230 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9489 19580-19585 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9490 19746-19751 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10054 20284-20289 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10055 20389-20394 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10056 20495-20500 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13739 22012-22017 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13740 22463-22468 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13741 22560-22565 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13742 23744-23749 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13743 24118-24123 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13744 24366-24371 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13745 24912-24917 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13746 25404-25409 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13747 25491-25496 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13748 25583-25588 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13749 25933-25938 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8383 16067-16072 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8384 16339-16344 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8385 16881-16886 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8386 17038-17043 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T698 78-83 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T699 774-779 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T700 911-916 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2360 2138-2149 http://purl.obolibrary.org/obo/GO_0005694 denotes chromosomal
T2361 3220-3224 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2362 4006-4010 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2363 4981-4986 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2364 5121-5126 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2842 5152-5156 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T2843 5424-5428 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3042 5493-5497 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T3043 5526-5530 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3044 5757-5762 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4180 6897-6902 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4181 7569-7574 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4182 8027-8035 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T4183 8090-8099 http://purl.obolibrary.org/obo/GO_0016020 denotes Membranes
T4184 8472-8481 http://purl.obolibrary.org/obo/GO_0016020 denotes membranes
T4185 8320-8328 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T10592 21318-21323 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10593 21359-21364 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10594 21596-21601 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13750 26687-26692 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13751 27569-27573 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13752 27652-27656 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13753 27800-27804 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13754 24789-24806 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complexes
T13755 27289-27299 http://purl.obolibrary.org/obo/GO_0005694 denotes chromosome

sentences

Id Subject Object Predicate Lexical cue
T105 0-144 Sentence denotes Down-regulation of interferon regulatory factor 4 gene expression in leukemic cells due to hypermethylation of CpG motifs in the promoter region
T106 156-464 Sentence denotes Although the bcr-abl translocation has been shown to be the causative genetic aberration in chronic myeloid leukemia (CML), there is mounting evidence that the deregulation of other genes, such as the transcription factor interferon regulatory factor 4 (IRF-4), is also implicated in the pathogenesis of CML.
T107 465-633 Sentence denotes Promoter methylation of CpG target sites or direct deletions/insertions of genes are mechanisms of a reversible or permanent silencing of gene expression, respectively.
T108 634-780 Sentence denotes Therefore, we investigated whether IRF-4 promoter methylation or mutation may be involved in the regulation of IRF-4 expression in leukemia cells.
T109 781-1013 Sentence denotes Whereas promoter mutations or structural rearrangements could be excluded as a cause of altered IRF-4 expression in hematopoietic cells, the IRF-4 promoter methylation status was found to significantly influence IRF-4 transcription.
T110 1014-1235 Sentence denotes First, treatment of IRF-4-negative lymphoid, myeloid and monocytic cell lines with the methylation-inhibitor 5-aza-2-deoxycytidine resulted in a time- and concentration-dependent increase of IRF-4 mRNA and protein levels.
T111 1236-1397 Sentence denotes Second, using a restriction-PCR-assay and bisulfite-sequencing we identified specifically methylated CpG sites in IRF-4-negative but not in IRF-4-positive cells.
T112 1398-1650 Sentence denotes Third, we clearly determined promoter methylation as a mechanism for IRF-4 down-regulation via reporter gene assays, but did not detect an association of methylational status and mRNA expression of DNA methyltransferases or methyl-CpG-binding proteins.
T113 1651-1796 Sentence denotes Together, these data suggest CpG site-specific IRF-4 promoter methylation as a putative mechanism of down-regulated IRF-4 expression in leukemia.
T1054 1811-2082 Sentence denotes Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder with a typical three phased course (chronic, accelerated and blastic phase) reflecting the loss of differentiation and malignant progress which inevitably leads to death after the blastic phase (1,2).
T1055 2083-2262 Sentence denotes The hallmark genetic aberration of CML is a reciprocal chromosomal translocation t(9;22) leading to expression of a bcr-abl fusion gene, an aberrant activated tyrosine kinase (2).
T1056 2263-2419 Sentence denotes Treatment with interferon α (IFN-α) prolongs survival of CML patients and is associated with a complete cytogenetic response in 5–33% of CML patients (1,2).
T1057 2420-2574 Sentence denotes Recently, we described an impaired expression of the interferon regulatory factor 4 (IRF-4) in CML, correlating with poor response to IFN-α treatment (3).
T1058 2575-2634 Sentence denotes The cause of the silencing of IRF-4 level remained unclear.
T1059 2635-2780 Sentence denotes Interferon regulatory factors (IRFs) are a family of transcriptional regulators defined by a characteristic homology in their DNA-binding domain.
T1060 2781-2937 Sentence denotes They play an important role in the regulation of various genes (such as IFNs, interleukins, MHC class I/II), apoptosis and differentiation/maturation (4–6).
T1061 2938-3021 Sentence denotes IRF-4 (ICSAT/Pip/MUM1/LSIRF) is one member with very restricted expression pattern:
T1062 3022-3093 Sentence denotes Predominately B- and activated T-lymphocytes are IRF-4 positive (7–11).
T1063 3094-3272 Sentence denotes In contrast to other IRFs, expression of IRF-4 cannot be induced by IFNs, but by antigen stimulation, crosslinking of T- or B-cell receptors or phorbol-myristate-acetate (10,11).
T1064 3273-3532 Sentence denotes Consistent with the restriction of expression to immunocompetent cells, mice with deletion of IRF-4 failed to develop mature and functionally active B- and T-lymphocytes (12), and the impaired expression of IRF-4 in CML was predominately found in T-cells (3).
T1065 3533-3609 Sentence denotes These data suggest a crucial role for IRF-4 in the function of immune cells.
T1066 3610-3846 Sentence denotes Methylation of dinucleotide cytosine-guanosine motifs (CpG), especially in CpG islands located in promoter regions, is one of the mechanisms of gene regulation in mammals and a common event of gene silencing in human neoplasias (13,14).
T1067 3847-3964 Sentence denotes As opposed to normal cells, hypermethylation of CpG islands is a frequently observed phenomenon in every cancer type.
T1068 3965-4128 Sentence denotes De novo DNA methylation of genes such as cell cycle, DNA repair, apoptosis and tumor suppressor genes is therefore thought to be involved in tumorigenesis (15–17).
T1069 4129-4239 Sentence denotes Examples for such aberrated genes are MGMT, DAPK, p14ARF, p15INK4b, p16INK4a, BRCA1, CDH13 and APAF-1 (17–19).
T1070 4240-4450 Sentence denotes In CML, methylation is known to regulate expression of the c-abl, the bcr gene and others (20–23), and the extent of methylation in the c-abl promoter has been shown to be associated with advanced disease (24).
T1071 4451-4598 Sentence denotes Hypermethylation due to overexpression of DNA methyltransferases (DNMTs) remains one possible explanation for de novo methylation in tumorigenesis.
T1072 4599-4685 Sentence denotes Recently, DNMTs have been shown to be up-regulated in hematopoietic malignancies (25).
T1073 4686-4897 Sentence denotes Methyl-CpG-binding proteins (MBPs) are thought to inhibit the binding of transcriptional factors to the promoter and are therefore discussed as one mechanism of transcription inhibition by hypermethylation (26).
T1074 4898-4987 Sentence denotes In this work, we studied mechanisms of IRF-4 gene expression silencing in leukemic cells.
T1075 4988-5127 Sentence denotes We analyzed the IRF-4 promoter region for genetic aberrations and methylational status in IRF-4-positive and -negative hematopoietic cells.
T2707 5152-5162 Sentence denotes Cell lines
T2708 5163-5419 Sentence denotes K-562, Jurkat and U-937 were obtained from the ATCC (American Type Culture Collection, Rockville, USA) and EM-2, LAMA-84, CML-T1, BV-173, SD-1 and RPMI-8226 from the DSMZ (Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany).
T2709 5420-5491 Sentence denotes All cell lines, except BV-173, SD-1 and RPMI-8226, were IRF-4-negative.
T2858 5493-5521 Sentence denotes Cell culture and stimulation
T2859 5522-5740 Sentence denotes All cell lines were maintained at 5% CO2 in RPMI 1640 medium with 1% glutamine (Gibco/BRL Eggenstein, Germany) supplemented with 10% fetal calf serum (Gibco/BRL), 1% penicillin/streptomycin (Biochrom, Berlin, Germany).
T2860 5741-5892 Sentence denotes When indicated, cells were treated with 5-aza-2-deoxycytidine (AzadC) or 5-azacytidine (AzaC) (Sigma, Taufkirchen, Germany) for different time periods.
T2861 5893-5971 Sentence denotes Owing to their chemical instability fresh substances were re-added every 24 h.
T3053 5973-6005 Sentence denotes Sequencing of the IRF-4 promoter
T3054 6006-6272 Sentence denotes For analysis of the IRF-4 promoter region for permanent aberrations such as insertions/deletions or mutation, we PCR-amplified two fragments from genomic DNA, which was extracted from depicted cell lines with a commercial kit (Qiagen, Hilde, Germany) as recommended.
T3055 6273-6300 Sentence denotes The primers were 1-forward:
T3056 6301-6341 Sentence denotes 5′-TTGAGATGGAGTCTTGCTCTGT-3′, 1-reverse:
T3057 6342-6383 Sentence denotes 5′-CCAGGACCTCAGGAGGCCAGTCA-3′; 2-forward:
T3058 6384-6427 Sentence denotes 5′-AGCGGTGAAACTGAGAGTGCGAGGT-3′, 2-reverse:
T3059 6428-6455 Sentence denotes 5′-GCCACATCGCTGCAGTTTAG-3′.
T3060 6456-6553 Sentence denotes The products were cloned with the ‘TOPO TA cloning kit’ (Invitrogen, Groningen, The Netherlands).
T3061 6554-6808 Sentence denotes After bacterial amplification of the cloned PCR fragments by standard procedures, at least three clones from each sample were sequenced with an automated sequencer (ABI Prism 377, Applied Bio-systems, Foster City, USA) as recommended by the manufacturer.
T3408 6810-6829 Sentence denotes Expression analysis
T3409 6830-6964 Sentence denotes To analyze the IRF-4 transcriptional level, RNA was extracted from cells using the commercial RNAzol-kit (Paesel, Frankfurt, Germany).
T3410 6965-7051 Sentence denotes An aliquot of 1 μg total RNA was used for cDNA synthesis as described previously (27).
T3411 7052-7189 Sentence denotes RNA expression analysis for IRF-4 and the reference gene β-actin was carried out by semi-quantitative PCR as described previously (3,27).
T3412 7190-7241 Sentence denotes PCR products were verified by automated sequencing.
T3413 7242-7388 Sentence denotes PCR primers and conditions for expression analysis of DNMT or MBP (DNMT1 DNMT3A, DNMT3B, MeCP, MBD1, MBD2 and MBD4) were published elsewhere (28).
T3414 7389-7506 Sentence denotes For analysis of IRF-4 protein expression, a standard immunoblotting assay was performed as described previously (29).
T3415 7507-7797 Sentence denotes Briefly, protein lysates were generated by incubating 1 × 106 cells in 100 µl RIPA buffer (1% NP-40, 0.5% sodiumdesoxycholate, 0.1% SDS, 100 µg/ml phenylmethylsulfonyl fluoride, 10 µl/ml protease-inhibitory-mix, 1 µmol/ml sodiumorthovanadate in phosphate-buffered saline) for 30 min on ice.
T3416 7798-7928 Sentence denotes After centrifugation, protein concentration of the supernatant was determined by BCA-method (Pierce, Rockford, IL) as recommended.
T3417 7929-8089 Sentence denotes Protein lysates (70–100 µg) were electrophoresed on polyacrylamide gels and transferred to a PVDF-membrane (Immobilon P, 0.45 µm; Millipore, Eschborn, Germany).
T3418 8090-8467 Sentence denotes Membranes were blocked with 2.5% blocking reagent (Boehringer Mannheim, Germany) in TBST buffer (4.44 g/l Tris–HCL, 2.65 g/l TrisOH, 8.07 g/l NaCl, 0.2 g/l KCl and 500 µl/l Tween-20 in H2O) and subsequently incubated with primary antibody as indicated and horseradish peroxidase-conjugated secondary antibody, anti-mouse or anti-goat IgG (DAKO, Hamburg, Germany), respectively.
T3419 8468-8576 Sentence denotes The membranes were then developed with an ECL detection kit (Amersham Pharmacia Biotech, Freiburg, Germany).
T3420 8577-8716 Sentence denotes The primary antibodies were goat anti-IRF-4/ICSAT (M-17) (Santa Cruz Biotechnology, Santa Cruz, CA) and mouse anti-β-actin (AC-74) (Sigma).
T4350 8718-8760 Sentence denotes Methylation-specific restriction-PCR-assay
T4351 8761-8825 Sentence denotes DNA was extracted with a commercial kit (Qiagen) as recommended.
T4352 8826-9069 Sentence denotes Since the restriction ability of several endonucleases is inhibited by methylation of their target sequence, we used methylation-sensitive enzymes HpaII and HaeII-isochizomer Bsp143II and Bsh1236I (MBI Fermentas, St Leon-Rot, Germany) (20,24).
T4353 9070-9199 Sentence denotes As control the methylation-resistant enzyme MspI and an enzyme with no recognition site in the target promoter, EcoRI, were used.
T4354 9200-9323 Sentence denotes DNA (0.8 µg) was digested by 40 U the respective enzyme for 6 h and, to ensure complete cleavage, additional 20 U for 16 h.
T4355 9324-9492 Sentence denotes Thereafter 100 ng of digested DNA was used to a PCR amplification of two fragments (F1 and F2) spanning part of the IRF-4 promoter (30) (GenBank U52683; see Figure 3A).
T4356 9493-9538 Sentence denotes The sequences of the primers were F1-forward:
T4357 9539-9631 Sentence denotes 5′-TTGAGATGGAGTCTTGCTCTGT-3′, F1-reverse: ATCACTTCCAGACTTCAGTTCACCT-3′ (341 bp); F2-forward:
T4358 9632-9676 Sentence denotes 5′-AAGGTGAACTGAAGTCTGGAAGTGA-3′, F2-reverse:
T4359 9677-9716 Sentence denotes 5′-CCAGGACCTCAGGAGGCCAGTCA-3′ (474 bp).
T4360 9717-9765 Sentence denotes The PCR conditions were described elsewhere (3).
T4361 9766-9836 Sentence denotes PCR was performed with an annealing temperature of 62°C and 35 cycles.
T4362 9837-10037 Sentence denotes When DNA was methylated at specific sites, the sensitive enzymes were not able to digest the DNA and amplification took place; in case of no methylation, DNA was digested and no product was generated.
T4363 10038-10149 Sentence denotes The PCR products were electrophoresed on a 3% agarose gel, were stained with ethidium bromide and photographed.
T4364 10150-10201 Sentence denotes PCR products were verified by automated sequencing.
T4932 10203-10222 Sentence denotes Bisulfite treatment
T4933 10223-10260 Sentence denotes DNA was extracted as described above.
T4934 10261-10440 Sentence denotes Bisulfite treatment of DNA, leading to conversion of unmethylated cytosine to uracil residues and no change of methylated cytosine residues, was performed as described as follows.
T4935 10441-10609 Sentence denotes Briefly, 1 µg of DNA and 2 µg of poly(dA–dT)(poly(dA–dT) copolymers (Amersham Pharmacia Biotech) were denaturated for 20 min at 42°C in 0.3 M NaOH in a volume of 50 µl.
T4936 10610-10932 Sentence denotes Fresh solutions of 30 µl of 10 mM hydrochinon (Sigma) and 530 µl of 3 M sodium bisulfite (pH 5.0; Sigma) were added, the solution was gently mixed, overlayed with mineral oil and incubated in the dark for 12–13 h at 50°C. The aqueous phase was recovered using the ‘Wizard DNA clean-up system’ (Promega, Mannheim, Germany).
T4937 10933-11089 Sentence denotes The purified DNA was subsequently mixed with 1 M NaOH to a final concentration of 0.3 M and incubated for 20 min at 37°C to ensure complete desulfonisation.
T4938 11090-11223 Sentence denotes DNA was ethanol precipitated in the presence of 1/10 vol of 3 M sodium acetate, washed with 70% ethanol and resuspended in 50 µl H2O.
T4939 11224-11439 Sentence denotes Subsequent PCR amplification of 4 µl bisulfite-treated DNA was used for cloning of two fragments of the IRF-4 promoter (BS-I and BS-II) into pCR2.1 vector with the ‘TOPO TA cloning kit’ (Invitrogen) (see Figure 3A).
T4940 11440-11863 Sentence denotes The primers used for PCR amplification of the BS-I and BS-II fragments contain the putative altered sequence of the sense strand due to bisulfite treatment (converted cytosine residues are written in bold letters): BS-I-forward 5′-TATTTGGATTTTTAGGGAGTTTTTTTT-3′, BS-I-reverse 5′-ACCCAACTCCCTTAAACTATTAAACT-3′ (187 bp); BS-II-forward 5′-AGTTTAATAGTTTAAGGGAGTTGGGT-3′, BS-II-reverse 5′-CTCACCCTAAACTCAAAACTAAAAAC-3′ (674 bp).
T4941 11864-12055 Sentence denotes After bacterial amplification of the cloned PCR fragments by standard procedures, eight clones from each sample were sequenced with an automated sequencer (ABI Prism 377, Applied Biosystems).
T5684 12057-12102 Sentence denotes In vitro methylation and reporter gene assays
T5685 12103-12189 Sentence denotes The IRF-4 promoter-reporter gene construct was generously provided by J. Hiscott (31).
T5686 12190-12377 Sentence denotes Constructs were methylated in vitro with CpG Methylase (M.Sss I) as recommended by the manufacturer (NE Biolabs) and complete methylation was checked via restriction analysis (Figure 5A).
T5687 12378-12489 Sentence denotes Reporter gene assays using the dual luciferase assay (Promega) were performed similar to previous reports (29).
T5688 12490-12657 Sentence denotes Briefly, 5 nM of the reporter construct and the transfection control construct expressing the renilla luciferase gene were transientlyco-expressed via electroporation.
T5689 12658-12740 Sentence denotes The control construct served as an internal reference for transfection efficiency.
T5690 12741-12876 Sentence denotes Forty-eight hours after transfection, luciferase activity was measured with a LB 96 P microlumat (EG&G Berthold, Bad Wildbad, Germany).
T5691 12877-12993 Sentence denotes IRF-4 promoter activation was quantified as a ratio of measured firefly light units (flu) relative to renilla (rlu).
T5692 12994-13047 Sentence denotes Each experiment was carried out at least three times.
T6214 13058-13138 Sentence denotes Absence of IRF-4 expression in leukemia cells is not due to promoter alterations
T6215 13139-13255 Sentence denotes We have previously demonstrated a lack of IRF-4 expression in leukemia patients and specifically in CML T-cells (3).
T6216 13256-13715 Sentence denotes Here, we demonstrate the absence of IRF-4 expression in various hematopoietic cell lines, such as Jurkat, a T-cell leukemia, CML-T1, a bcr-abl-positive T-cell line, K-562, a bcr-abl-positve erythroleukemia, U-937, a monocytic leukemia, EM-2 and LAMA-84, bcr-abl-positve myeloid leukemia, but not in SD-1, a bcr-abl-positive acute lymphoblastic leukemia (pre B-ALL), RPMI-8226, a multiple myeloma and BV-173, a bcr-abl-positive B-cell line (Figures 1A and 5D).
T6217 13716-13872 Sentence denotes After sequencing of the IRF-4 promoter, it could be excluded that absence of IRF-4 expression in any of the above cell lines was due to genetic aberrations.
T6218 13873-14045 Sentence denotes However, 2 bp changes (nucleotide −1081, T→C and −1068, A→C) could be detected in both the IRF-4-positive BV-173 and the IRF-4-negative LAMA-84, EM-2 and K-562 (Figure 1B).
T6219 14046-14251 Sentence denotes At position −116 an A→C substitution was found in EM-2, K-562 and CML-T1, whereas Jurkat, BV-173 and SD-1 exhibited a mixed A/C sequence and U-937, LAMA-84 and RPMI-8226 no substitution at all (Figure 1B).
T6220 14252-14324 Sentence denotes Consequently, these alterations are unlikely to affect IRF-4 expression.
T7004 14326-14407 Sentence denotes Increase of IRF-4 expression in hematopoietic cells after demethylating treatment
T7005 14408-14515 Sentence denotes We next analyzed whether promoter methylation could be responsible for down-regulation of IRF-4 expression.
T7006 14516-14622 Sentence denotes A region including exon1 in the IRF-4 promoter exhibited a large number of CpG-rich sequences (Figure 3A).
T7007 14623-14819 Sentence denotes Several chemical substances such as 5-aza-2-deoxycytidine (AzadC) or 5-azacytidine (AzaC) inhibit de novo and maintenance methylation, and thus can be used to discern promoter methylation (32,33).
T7008 14820-14863 Sentence denotes We used AzadC to generate unmethylated DNA.
T7009 14864-15047 Sentence denotes A 72 h AzadC-treatment resulted in a concentration-dependent activation of IRF-4 transcription in Jurkat and CML-T1 T-cells as well as in U-937, K-562 and EM-2 cell lines (Figure 2A).
T7010 15048-15215 Sentence denotes IRF-4 transcription was induced in a time-dependent manner and was observed as early as 24 h after treatment with AzadC and increased over time until 72 h (Figure 2B).
T7011 15216-15366 Sentence denotes Time and strength of the appearance of IRF-4 transcripts varied among cell lines, i.e. CML-T1 responded strongest to AzadC-treatment (data not shown).
T7012 15367-15502 Sentence denotes In line with this, AzadC-treatment of CML-T1 and LAMA-84 cells also translated in an induction of IRF-4 protein expression (Figure 2C).
T7013 15503-15642 Sentence denotes Accordingly, treatment of the IRF-4-positive cell line BV-173, SD-1 and RPMI-8226 with AzadC had no effect on IRF-4 expression (Figure 2D).
T7014 15643-15784 Sentence denotes There was no difference in the effects of AzaC versus AzadC, as both increased the IRF-4 mRNA level in CML-T1 cells as well (data not shown).
T7015 15785-15970 Sentence denotes This implied that promoter methylation may control IRF-4 expression, but an alternative explanation may be activation of positive transcriptional regulators of IRF-4 by AzadC (or AzaC).
T7831 15972-16072 Sentence denotes Methylation-sensitive enzymes do not cut specific sites in the IRF-4 promoter in hematopoietic cells
T7832 16073-16312 Sentence denotes To further investigate promoter methylation as a regulatory mechanism of IRF-4 gene expression, restriction-PCR-assays were performed (20,24), where only methylated DNA would not be cut enabling subsequent PCR amplification and vice versa.
T7833 16313-16490 Sentence denotes Genomic DNA from leukemic cells Jurkat, CML-T1, U-937, K-562, EM-2 and BV-173 was digested with the methylation-sensitive enzymes HpaII, Bsh1236I and HaeII-isochizomer Bsp143II.
T7834 16491-16616 Sentence denotes EcoRI, which has no recognition site within the IRF-4 promoter, and the methylation-resistant enzyme MspI served as controls.
T7835 16617-16718 Sentence denotes Two separate amplification reactions were performed, generating two fragments, F1 and F2 (Figure 3A).
T7836 16719-17005 Sentence denotes After digestion with HpaII and Bsp143II a sufficient PCR amplification of F1 and F2 was detected in DNA from IRF-4-negative Jurkat, CML-T1, U-937, K-562 and EM-2 cells, suggesting a promoter methylation (and restriction protection) at the respective recognition sites (Figure 3B and C).
T7837 17006-17141 Sentence denotes Notably, in IRF-4-positive SD-1 cells digestion with the methylation-sensitive enzymes completely inhibited amplification of F1 and F2.
T7838 17142-17338 Sentence denotes In IRF-4-positive BV-173 cells a HpaII, but not a Bsh1236I digestion, significantly reduced the amplifiable DNA message of F2 (Figure 3C), whereas amplification of F1 was not affected (Figure 3B).
T7839 17339-17534 Sentence denotes This implied that IRF-4 transcription in SD-1 and BV-173 cells is associated with less promoter methylation (in BV-173 especially at HpaII sites) as compared with the tested IRF-4-negative cells.
T8559 17536-17614 Sentence denotes Specific CpG sites in the IRF-4 promoter are methylated in hematopoietic cells
T8560 17615-17946 Sentence denotes In order to exactly map the methylation sites within the IRF-4 promoter, we treated DNA of Jurkat, CML-T1, U-937, K-562 and EM-2 cells as well as of SD-1, RPMI-8226 and BV-173 control cells with bisulfite, which chemically converts unmethylated cytosine to uracil, whereas it has no effect on methylated cytosine, i.e. in CpG (34).
T8561 17947-18029 Sentence denotes This technique is especially useful for detection of unknown methylation patterns.
T8562 18030-18209 Sentence denotes PCR amplification, cloning and sequencing of the bisulfite-treated DNA showed a specific methylation pattern of the analyzed 62 CpG sites in all cell lines (Figure 4 and Table 1).
T8563 18210-18409 Sentence denotes In general, the methylational status ranged from one cell line with a nearly non-methylated IRF-4 promoter (SD-1, IRF-4-positive) to a completely methylated IRF-4 promoter in CML-T1 (IRF-4-negative).
T8564 18410-18604 Sentence denotes Interestingly, the percentage of CpG methylation in the IRF-4 promoter from IRF-4-positive cells was very low (mean 24%) as compared with IRF-4-negative cells (mean 94%) (Figure 4A and Table 1).
T8565 18605-18971 Sentence denotes A 5′-region (R1) with 13 hypermethylated CpG sites (mean number of methylated clones 5.5 of 8 with 77% methylated CpGs) was found in most cells (except SD-1 and RPMI-8226) and a 3′-region (R3) of 6 hypomethylated CpG sites (mean number of methylated clones 1.7 of 8 with 33% methylated CpGs) was found in most cells (except CML-T1 and U-937) (Figure 4A and Table 1).
T8566 18972-19249 Sentence denotes Intriguingly, a stretch of 13 CpG sites (#10–22; R2) was detected in between these regions, which were highly methylated in IRF-4-negative (mean number of methylated clones 7.1 of 8 with 89% methylated CpGs) but totally non-methylated in IRF-4-positive cells (Figure 4A and B).
T8567 19250-19443 Sentence denotes Furthermore, three CpG sites at the 5′ end (#54, 56, 58) and two CpG motifs at the 3′ end (#1, 2) showed this direct correlation between high methylation status and absence of IRF-4 expression.
T8568 19444-19620 Sentence denotes In addition, two CpG sites located in a NFκB (#48) and a SP1 element (#45) are less methylated in IRF-4-positive than in IRF-4-negative cells (mean number of methylated clones:
T8569 19621-19637 Sentence denotes 1/8 versus 8/8).
T8570 19638-19752 Sentence denotes These results indicate the involvement of CpG methylation in the regulation of IRF-4 expression in leukemic cells.
T9690 19754-19837 Sentence denotes In vitro methylation of an IRF-4 promoter-reporter construct decreases its activity
T9691 19838-20038 Sentence denotes To provide evidence for a direct effect of methylational status on IRF-4 promoter activity we performed reporter gene assays with IRF-4 promoter constructs before and after their in vitro methylation.
T9692 20039-20170 Sentence denotes A complete methylation of these constructs was checked via restriction assays with methylation-sensitive endonucleases (Figure 5A).
T9693 20171-20311 Sentence denotes Intriguingly, methylation of the IRF-4 promoter significantly decreased promoter activity in IRF-4-positive SD-1 cells by 85.0% (Figure 5B).
T9694 20312-20513 Sentence denotes The silencing effect of CpG methylation was not restricted to IRF-4-positive cells, since in vitro methylation led to a 92.9% abrogation of promoter activity in IRF-4-negative Jurkat cells (Figure 5C).
T9695 20514-20687 Sentence denotes In contrast, control methylation of a reporter construct with a different promoter (FasL) as well as an empty vector had no effect on the reporter activity (data not shown).
T9696 20688-20782 Sentence denotes These data proved a direct association between methylation and activity of the IRF-4 promoter.
T10244 20784-20911 Sentence denotes mRNA expression of DNA methyltransferases and methyl-CpG-binding proteins may not be associated with IRF-4 promoter methylation
T10245 20912-21138 Sentence denotes Since abundance of DNMT and MBP contribute to promoter regulation via methylation (25,26,28), we studied their mRNA expression to investigate a possible mechanism for the observed methylation differences in the IRF-4 promoter.
T10246 21139-21336 Sentence denotes To this end, we did not detect a significant difference in DNMT (DNMT1, DNMT3A and DNMT3B) or MBP (MBD1, MBD2, MBD4 and MeCP) mRNA expression between IRF-4-positive and -negative cells (Figure 5D).
T10247 21337-21492 Sentence denotes In fact, all analyzed cells had moderate to high mRNA levels of these tested DNMT/MBPs and differences in expression were not correlated with IRF-4 status.
T10248 21493-21661 Sentence denotes These results indicate a distinct cause of the methylation differences in IRF-4-positive and -negative cells rather than changes in the DNMT and MBP mRNA transcription.
T11278 21674-21760 Sentence denotes Many genetic lesions are known to influence gene expression of tumor suppressor genes.
T11279 21761-21943 Sentence denotes Whereas mutations and deletions or insertions have permanent effects, reversible mechanisms are gene methylation, or expression and activation of transcription factors, respectively.
T11280 21944-22075 Sentence denotes We studied a putative cause for absent IRF-4 expression in leukemia cells and first focused on genetic aberrations of the promoter.
T11281 22076-22185 Sentence denotes We observed no genetic alterations in the IRF-4 promoter, which can account for the lack of IRF-4 expression:
T11282 22186-22597 Sentence denotes The detected base pair changes at position −1081 (T→C substitution), at position −1068 (A→C substitution) and at position −116 (A→C substitution) are unlikely responsible for absent IRF-4-expression since the first two mutations were found both in IRF-4-positive and -negative cells whereas the latter change was not detected consistently in all IRF-4-negative or -positive cells and may thus be a polymorphism.
T11283 22598-22787 Sentence denotes All three substitutions did not change any known putative transcription factor binding sites (30,31) and also do not affect any restriction sites or primer binding sites of the used assays.
T11284 22788-22956 Sentence denotes However, permanent genetic variations in the IRF-4 coding sequence, such as deletions or mutations resulting in stop-codons have not been excluded by sequence analysis.
T11285 22957-23139 Sentence denotes Since IRF-4 expression in cell lines and CML can be induced by demethylation and successful IFN-α therapy (3), respectively, the existence of such genetic aberrations seems unlikely.
T11286 23140-23459 Sentence denotes We then investigated whether the previously described down-regulation of IRF-4 expression in human myeloid leukemias was due to a differential hypermethylation of the promoter, since the presented re-expression due to AzadC-treatment might also be a result of activation of positive transcriptional regulators of IRF-4.
T11287 23460-23641 Sentence denotes Methylation of CpG sites is a common mechanism of silencing genes in leukemia and has also been shown for another IRF, IRF-7 (35) and for PU.1 (36), an interacting partner of IRF-4.
T11288 23642-23844 Sentence denotes To elucidate the relevance of this mechanism for the regulation of IRF-4 expression, various leukemic cells were treated with demethylating agents and promoters were sequenced after bisulfite treatment.
T11289 23845-23973 Sentence denotes We found that IRF-4 expression could indeed be connected to the methylation status of distinct CpG motifs in the IRF-4 promoter.
T11290 23974-24124 Sentence denotes In Figure 4A, those CpG sites are shown (bottom line), whose hypermethylation may account for the absence of IRF-4 expression in the respective cells.
T11291 24125-24251 Sentence denotes One of them (#54) is adjacent to an identified regulatory element (NFκB-site), indicating a possible involvement of this site.
T11292 24252-24372 Sentence denotes At two further CpG sites (#48, 45) the methylation status in IRF-4-positive was lower than that of IRF-4-negative cells.
T11293 24373-24500 Sentence denotes These CpG sites are located in an NFκB and an SP1 element (31) and thus may also play a role in regulation of IRF-4 expression.
T11294 24501-24695 Sentence denotes It has been shown that NFκB elements play an important role in IRF-4 induction as IRF-4 expression depends on binding of the transactivator c-Rel to these elements in the IRF-4 promoter (31,37).
T11295 24696-24918 Sentence denotes Furthermore, methylation of the central CpG in the NFκB element inhibits binding of the NFκB protein complexes (38), promoting the significance of the observed methylation differences in IRF-4-positive and -negative cells.
T11296 24919-25117 Sentence denotes Via in vitro methylation and reporter gene assays we could clearly appoint the silencing of the IRF-4 promoter to a methylation effect, which may thus be the mechanism of IRF-4 deregulation in vivo.
T11297 25118-25246 Sentence denotes One possible cause for the aberrant methylation in tumorigenesis is an increased level of DNMTs during the pathogenetic process.
T11298 25247-25363 Sentence denotes In colon, lung and hematologic malignancies, overexpression of DNMT1, a maintenance DNMT, has been detected (39–41).
T11299 25364-25594 Sentence denotes Furthermore, it has been shown that CML cells in the acute phase exhibited elevated levels of the three known DNMTs, while CML cells in chronic phase expressed normal levels of DNMTs if compared with normal bone marrow cells (25).
T11300 25595-25728 Sentence denotes Interestingly, a positive correlation between DNMT1 expression levels and hypermethylation of p15INK4b has been detected in AML (25).
T11301 25729-25939 Sentence denotes In this work, we did not detect significant mRNA expression differences of selected DNMT or MBP, making it an unlikely cause for the observed methylation and thus IRF-4 expression differences in leukemia cells.
T11302 25940-26117 Sentence denotes The finding that IRF-4 expression is silenced by promoter hypermethylation might represent a mechanism that accounts for the previously observed loss of IRF-4 expression in CML.
T11303 26118-26310 Sentence denotes Indeed, several clinical trials with leukemia patients and patients with myelodysplastic syndromes demonstrated the potential clinical benefit of a treatment with demethylating agents (42–45).
T11304 26311-26455 Sentence denotes The expression of another IRF, IFN consensus sequence binding protein (ICSBP/IRF-8), is impaired in myeloid leukemias especially CML (27,46,47).
T11305 26456-26704 Sentence denotes But in contrast to IRF-4, the loss of this IRF could not be reverted in ICSBP-negative cell lines (EM-2, CML-T1, K-562 and LAMA-84) by treatment with AzadC (Figure 6) and AzadC has no effect on ICSBP levels in ICSBP-positive U-937 cells (Figure 6).
T11306 26705-26775 Sentence denotes These data suggest a distinct regulatory mechanism for these two IRFs.
T11307 26776-27038 Sentence denotes IRF-4, similar to many other classical tumor suppressor genes p15INK4b, p16INK4a or p53, may thus be a subject of alterations in the promoter methylation status leading to expression changes, which might contribute to the initiation and/or progression of cancer.
T11308 27039-27178 Sentence denotes Still, the obvious functional diversity of IRF-4 remains remarkable and cannot be fully explained by the IRF-4 promoter methylation status.
T11309 27179-27244 Sentence denotes For example, IRF-4 is primarily known for its oncogenic features.
T11310 27245-27446 Sentence denotes In multiple myeloma (MM) a translocation on chromosome 14q was reported to lead to a fusion gene of immunoglobulin heavy-chain (IgH) and IRF-4 resulting in a subsequent overexpression of IRF-4 (48,49).
T11311 27447-27680 Sentence denotes In addition, abundant IRF-4 expression was found to be a marker for various subsets of lymphomas, such as diffuse large B-cell lymphomas, primary effusion lymphoma, and marginal zone lymphoma, and adult T-cell leukemia (11,31,50–52).
T11312 27681-27736 Sentence denotes This draws a more complex picture of the role of IRF-4.
T11313 27737-27976 Sentence denotes Down-regulation of IRF-4 may promote leukemogenesis in myeloid cell context (3), which was recently confirmed in IRF-4−/− ICSBP−/− double knock-out mice (53), while IRF-4 up-regulation may induce a growth advantage in lymphomas or MM (48).
T11314 27977-28193 Sentence denotes Taken together, our data suggest that IRF-4 promoter methylation regulates IRF-4 expression, and that aberrant expression of IRF-4 in certain types of leukemia may be a consequence of IRF-4 promoter hypermethylation.
T1 0-144 Sentence denotes Down-regulation of interferon regulatory factor 4 gene expression in leukemic cells due to hypermethylation of CpG motifs in the promoter region
T2 147-155 Sentence denotes Abstract
T3 156-464 Sentence denotes Although the bcr-abl translocation has been shown to be the causative genetic aberration in chronic myeloid leukemia (CML), there is mounting evidence that the deregulation of other genes, such as the transcription factor interferon regulatory factor 4 (IRF-4), is also implicated in the pathogenesis of CML.
T4 465-633 Sentence denotes Promoter methylation of CpG target sites or direct deletions/insertions of genes are mechanisms of a reversible or permanent silencing of gene expression, respectively.
T5 634-780 Sentence denotes Therefore, we investigated whether IRF-4 promoter methylation or mutation may be involved in the regulation of IRF-4 expression in leukemia cells.
T6 781-1013 Sentence denotes Whereas promoter mutations or structural rearrangements could be excluded as a cause of altered IRF-4 expression in hematopoietic cells, the IRF-4 promoter methylation status was found to significantly influence IRF-4 transcription.
T7 1014-1235 Sentence denotes First, treatment of IRF-4-negative lymphoid, myeloid and monocytic cell lines with the methylation-inhibitor 5-aza-2-deoxycytidine resulted in a time- and concentration-dependent increase of IRF-4 mRNA and protein levels.
T8 1236-1397 Sentence denotes Second, using a restriction-PCR-assay and bisulfite-sequencing we identified specifically methylated CpG sites in IRF-4-negative but not in IRF-4-positive cells.
T9 1398-1650 Sentence denotes Third, we clearly determined promoter methylation as a mechanism for IRF-4 down-regulation via reporter gene assays, but did not detect an association of methylational status and mRNA expression of DNA methyltransferases or methyl-CpG-binding proteins.
T10 1651-1796 Sentence denotes Together, these data suggest CpG site-specific IRF-4 promoter methylation as a putative mechanism of down-regulated IRF-4 expression in leukemia.
T11 1798-1810 Sentence denotes INTRODUCTION
T12 1811-2082 Sentence denotes Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder with a typical three phased course (chronic, accelerated and blastic phase) reflecting the loss of differentiation and malignant progress which inevitably leads to death after the blastic phase (1,2).
T13 2083-2262 Sentence denotes The hallmark genetic aberration of CML is a reciprocal chromosomal translocation t(9;22) leading to expression of a bcr-abl fusion gene, an aberrant activated tyrosine kinase (2).
T14 2263-2419 Sentence denotes Treatment with interferon α (IFN-α) prolongs survival of CML patients and is associated with a complete cytogenetic response in 5–33% of CML patients (1,2).
T15 2420-2574 Sentence denotes Recently, we described an impaired expression of the interferon regulatory factor 4 (IRF-4) in CML, correlating with poor response to IFN-α treatment (3).
T16 2575-2634 Sentence denotes The cause of the silencing of IRF-4 level remained unclear.
T17 2635-2780 Sentence denotes Interferon regulatory factors (IRFs) are a family of transcriptional regulators defined by a characteristic homology in their DNA-binding domain.
T18 2781-2937 Sentence denotes They play an important role in the regulation of various genes (such as IFNs, interleukins, MHC class I/II), apoptosis and differentiation/maturation (4–6).
T19 2938-3021 Sentence denotes IRF-4 (ICSAT/Pip/MUM1/LSIRF) is one member with very restricted expression pattern:
T20 3022-3093 Sentence denotes Predominately B- and activated T-lymphocytes are IRF-4 positive (7–11).
T21 3094-3272 Sentence denotes In contrast to other IRFs, expression of IRF-4 cannot be induced by IFNs, but by antigen stimulation, crosslinking of T- or B-cell receptors or phorbol-myristate-acetate (10,11).
T22 3273-3532 Sentence denotes Consistent with the restriction of expression to immunocompetent cells, mice with deletion of IRF-4 failed to develop mature and functionally active B- and T-lymphocytes (12), and the impaired expression of IRF-4 in CML was predominately found in T-cells (3).
T23 3533-3609 Sentence denotes These data suggest a crucial role for IRF-4 in the function of immune cells.
T24 3610-3846 Sentence denotes Methylation of dinucleotide cytosine-guanosine motifs (CpG), especially in CpG islands located in promoter regions, is one of the mechanisms of gene regulation in mammals and a common event of gene silencing in human neoplasias (13,14).
T25 3847-3964 Sentence denotes As opposed to normal cells, hypermethylation of CpG islands is a frequently observed phenomenon in every cancer type.
T26 3965-4128 Sentence denotes De novo DNA methylation of genes such as cell cycle, DNA repair, apoptosis and tumor suppressor genes is therefore thought to be involved in tumorigenesis (15–17).
T27 4129-4239 Sentence denotes Examples for such aberrated genes are MGMT, DAPK, p14ARF, p15INK4b, p16INK4a, BRCA1, CDH13 and APAF-1 (17–19).
T28 4240-4450 Sentence denotes In CML, methylation is known to regulate expression of the c-abl, the bcr gene and others (20–23), and the extent of methylation in the c-abl promoter has been shown to be associated with advanced disease (24).
T29 4451-4598 Sentence denotes Hypermethylation due to overexpression of DNA methyltransferases (DNMTs) remains one possible explanation for de novo methylation in tumorigenesis.
T30 4599-4685 Sentence denotes Recently, DNMTs have been shown to be up-regulated in hematopoietic malignancies (25).
T31 4686-4897 Sentence denotes Methyl-CpG-binding proteins (MBPs) are thought to inhibit the binding of transcriptional factors to the promoter and are therefore discussed as one mechanism of transcription inhibition by hypermethylation (26).
T32 4898-4987 Sentence denotes In this work, we studied mechanisms of IRF-4 gene expression silencing in leukemic cells.
T33 4988-5127 Sentence denotes We analyzed the IRF-4 promoter region for genetic aberrations and methylational status in IRF-4-positive and -negative hematopoietic cells.
T34 5129-5150 Sentence denotes MATERIALS AND METHODS
T35 5152-5162 Sentence denotes Cell lines
T36 5163-5419 Sentence denotes K-562, Jurkat and U-937 were obtained from the ATCC (American Type Culture Collection, Rockville, USA) and EM-2, LAMA-84, CML-T1, BV-173, SD-1 and RPMI-8226 from the DSMZ (Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany).
T37 5420-5491 Sentence denotes All cell lines, except BV-173, SD-1 and RPMI-8226, were IRF-4-negative.
T38 5493-5521 Sentence denotes Cell culture and stimulation
T39 5522-5740 Sentence denotes All cell lines were maintained at 5% CO2 in RPMI 1640 medium with 1% glutamine (Gibco/BRL Eggenstein, Germany) supplemented with 10% fetal calf serum (Gibco/BRL), 1% penicillin/streptomycin (Biochrom, Berlin, Germany).
T40 5741-5892 Sentence denotes When indicated, cells were treated with 5-aza-2-deoxycytidine (AzadC) or 5-azacytidine (AzaC) (Sigma, Taufkirchen, Germany) for different time periods.
T41 5893-5971 Sentence denotes Owing to their chemical instability fresh substances were re-added every 24 h.
T42 5973-6005 Sentence denotes Sequencing of the IRF-4 promoter
T43 6006-6272 Sentence denotes For analysis of the IRF-4 promoter region for permanent aberrations such as insertions/deletions or mutation, we PCR-amplified two fragments from genomic DNA, which was extracted from depicted cell lines with a commercial kit (Qiagen, Hilde, Germany) as recommended.
T44 6273-6300 Sentence denotes The primers were 1-forward:
T45 6301-6341 Sentence denotes 5′-TTGAGATGGAGTCTTGCTCTGT-3′, 1-reverse:
T46 6342-6383 Sentence denotes 5′-CCAGGACCTCAGGAGGCCAGTCA-3′; 2-forward:
T47 6384-6427 Sentence denotes 5′-AGCGGTGAAACTGAGAGTGCGAGGT-3′, 2-reverse:
T48 6428-6455 Sentence denotes 5′-GCCACATCGCTGCAGTTTAG-3′.
T49 6456-6553 Sentence denotes The products were cloned with the ‘TOPO TA cloning kit’ (Invitrogen, Groningen, The Netherlands).
T50 6554-6808 Sentence denotes After bacterial amplification of the cloned PCR fragments by standard procedures, at least three clones from each sample were sequenced with an automated sequencer (ABI Prism 377, Applied Bio-systems, Foster City, USA) as recommended by the manufacturer.
T51 6810-6829 Sentence denotes Expression analysis
T52 6830-6964 Sentence denotes To analyze the IRF-4 transcriptional level, RNA was extracted from cells using the commercial RNAzol-kit (Paesel, Frankfurt, Germany).
T53 6965-7051 Sentence denotes An aliquot of 1 μg total RNA was used for cDNA synthesis as described previously (27).
T54 7052-7189 Sentence denotes RNA expression analysis for IRF-4 and the reference gene β-actin was carried out by semi-quantitative PCR as described previously (3,27).
T55 7190-7241 Sentence denotes PCR products were verified by automated sequencing.
T56 7242-7388 Sentence denotes PCR primers and conditions for expression analysis of DNMT or MBP (DNMT1 DNMT3A, DNMT3B, MeCP, MBD1, MBD2 and MBD4) were published elsewhere (28).
T57 7389-7506 Sentence denotes For analysis of IRF-4 protein expression, a standard immunoblotting assay was performed as described previously (29).
T58 7507-7797 Sentence denotes Briefly, protein lysates were generated by incubating 1 × 106 cells in 100 µl RIPA buffer (1% NP-40, 0.5% sodiumdesoxycholate, 0.1% SDS, 100 µg/ml phenylmethylsulfonyl fluoride, 10 µl/ml protease-inhibitory-mix, 1 µmol/ml sodiumorthovanadate in phosphate-buffered saline) for 30 min on ice.
T59 7798-7928 Sentence denotes After centrifugation, protein concentration of the supernatant was determined by BCA-method (Pierce, Rockford, IL) as recommended.
T60 7929-8089 Sentence denotes Protein lysates (70–100 µg) were electrophoresed on polyacrylamide gels and transferred to a PVDF-membrane (Immobilon P, 0.45 µm; Millipore, Eschborn, Germany).
T61 8090-8467 Sentence denotes Membranes were blocked with 2.5% blocking reagent (Boehringer Mannheim, Germany) in TBST buffer (4.44 g/l Tris–HCL, 2.65 g/l TrisOH, 8.07 g/l NaCl, 0.2 g/l KCl and 500 µl/l Tween-20 in H2O) and subsequently incubated with primary antibody as indicated and horseradish peroxidase-conjugated secondary antibody, anti-mouse or anti-goat IgG (DAKO, Hamburg, Germany), respectively.
T62 8468-8576 Sentence denotes The membranes were then developed with an ECL detection kit (Amersham Pharmacia Biotech, Freiburg, Germany).
T63 8577-8716 Sentence denotes The primary antibodies were goat anti-IRF-4/ICSAT (M-17) (Santa Cruz Biotechnology, Santa Cruz, CA) and mouse anti-β-actin (AC-74) (Sigma).
T64 8718-8760 Sentence denotes Methylation-specific restriction-PCR-assay
T65 8761-8825 Sentence denotes DNA was extracted with a commercial kit (Qiagen) as recommended.
T66 8826-9069 Sentence denotes Since the restriction ability of several endonucleases is inhibited by methylation of their target sequence, we used methylation-sensitive enzymes HpaII and HaeII-isochizomer Bsp143II and Bsh1236I (MBI Fermentas, St Leon-Rot, Germany) (20,24).
T67 9070-9199 Sentence denotes As control the methylation-resistant enzyme MspI and an enzyme with no recognition site in the target promoter, EcoRI, were used.
T68 9200-9323 Sentence denotes DNA (0.8 µg) was digested by 40 U the respective enzyme for 6 h and, to ensure complete cleavage, additional 20 U for 16 h.
T69 9324-9492 Sentence denotes Thereafter 100 ng of digested DNA was used to a PCR amplification of two fragments (F1 and F2) spanning part of the IRF-4 promoter (30) (GenBank U52683; see Figure 3A).
T70 9493-9538 Sentence denotes The sequences of the primers were F1-forward:
T71 9539-9631 Sentence denotes 5′-TTGAGATGGAGTCTTGCTCTGT-3′, F1-reverse: ATCACTTCCAGACTTCAGTTCACCT-3′ (341 bp); F2-forward:
T72 9632-9676 Sentence denotes 5′-AAGGTGAACTGAAGTCTGGAAGTGA-3′, F2-reverse:
T73 9677-9716 Sentence denotes 5′-CCAGGACCTCAGGAGGCCAGTCA-3′ (474 bp).
T74 9717-9765 Sentence denotes The PCR conditions were described elsewhere (3).
T75 9766-9836 Sentence denotes PCR was performed with an annealing temperature of 62°C and 35 cycles.
T76 9837-10037 Sentence denotes When DNA was methylated at specific sites, the sensitive enzymes were not able to digest the DNA and amplification took place; in case of no methylation, DNA was digested and no product was generated.
T77 10038-10149 Sentence denotes The PCR products were electrophoresed on a 3% agarose gel, were stained with ethidium bromide and photographed.
T78 10150-10201 Sentence denotes PCR products were verified by automated sequencing.
T79 10203-10222 Sentence denotes Bisulfite treatment
T80 10223-10260 Sentence denotes DNA was extracted as described above.
T81 10261-10440 Sentence denotes Bisulfite treatment of DNA, leading to conversion of unmethylated cytosine to uracil residues and no change of methylated cytosine residues, was performed as described as follows.
T82 10441-10609 Sentence denotes Briefly, 1 µg of DNA and 2 µg of poly(dA–dT)(poly(dA–dT) copolymers (Amersham Pharmacia Biotech) were denaturated for 20 min at 42°C in 0.3 M NaOH in a volume of 50 µl.
T83 10610-10831 Sentence denotes Fresh solutions of 30 µl of 10 mM hydrochinon (Sigma) and 530 µl of 3 M sodium bisulfite (pH 5.0; Sigma) were added, the solution was gently mixed, overlayed with mineral oil and incubated in the dark for 12–13 h at 50°C.
T84 10832-10932 Sentence denotes The aqueous phase was recovered using the ‘Wizard DNA clean-up system’ (Promega, Mannheim, Germany).
T85 10933-11089 Sentence denotes The purified DNA was subsequently mixed with 1 M NaOH to a final concentration of 0.3 M and incubated for 20 min at 37°C to ensure complete desulfonisation.
T86 11090-11223 Sentence denotes DNA was ethanol precipitated in the presence of 1/10 vol of 3 M sodium acetate, washed with 70% ethanol and resuspended in 50 µl H2O.
T87 11224-11439 Sentence denotes Subsequent PCR amplification of 4 µl bisulfite-treated DNA was used for cloning of two fragments of the IRF-4 promoter (BS-I and BS-II) into pCR2.1 vector with the ‘TOPO TA cloning kit’ (Invitrogen) (see Figure 3A).
T88 11440-11863 Sentence denotes The primers used for PCR amplification of the BS-I and BS-II fragments contain the putative altered sequence of the sense strand due to bisulfite treatment (converted cytosine residues are written in bold letters): BS-I-forward 5′-TATTTGGATTTTTAGGGAGTTTTTTTT-3′, BS-I-reverse 5′-ACCCAACTCCCTTAAACTATTAAACT-3′ (187 bp); BS-II-forward 5′-AGTTTAATAGTTTAAGGGAGTTGGGT-3′, BS-II-reverse 5′-CTCACCCTAAACTCAAAACTAAAAAC-3′ (674 bp).
T89 11864-12055 Sentence denotes After bacterial amplification of the cloned PCR fragments by standard procedures, eight clones from each sample were sequenced with an automated sequencer (ABI Prism 377, Applied Biosystems).
T90 12057-12102 Sentence denotes In vitro methylation and reporter gene assays
T91 12103-12175 Sentence denotes The IRF-4 promoter-reporter gene construct was generously provided by J.
T92 12176-12189 Sentence denotes Hiscott (31).
T93 12190-12377 Sentence denotes Constructs were methylated in vitro with CpG Methylase (M.Sss I) as recommended by the manufacturer (NE Biolabs) and complete methylation was checked via restriction analysis (Figure 5A).
T94 12378-12489 Sentence denotes Reporter gene assays using the dual luciferase assay (Promega) were performed similar to previous reports (29).
T95 12490-12657 Sentence denotes Briefly, 5 nM of the reporter construct and the transfection control construct expressing the renilla luciferase gene were transientlyco-expressed via electroporation.
T96 12658-12740 Sentence denotes The control construct served as an internal reference for transfection efficiency.
T97 12741-12876 Sentence denotes Forty-eight hours after transfection, luciferase activity was measured with a LB 96 P microlumat (EG&G Berthold, Bad Wildbad, Germany).
T98 12877-12993 Sentence denotes IRF-4 promoter activation was quantified as a ratio of measured firefly light units (flu) relative to renilla (rlu).
T99 12994-13047 Sentence denotes Each experiment was carried out at least three times.
T100 13049-13056 Sentence denotes RESULTS
T101 13058-13138 Sentence denotes Absence of IRF-4 expression in leukemia cells is not due to promoter alterations
T102 13139-13255 Sentence denotes We have previously demonstrated a lack of IRF-4 expression in leukemia patients and specifically in CML T-cells (3).
T103 13256-13715 Sentence denotes Here, we demonstrate the absence of IRF-4 expression in various hematopoietic cell lines, such as Jurkat, a T-cell leukemia, CML-T1, a bcr-abl-positive T-cell line, K-562, a bcr-abl-positve erythroleukemia, U-937, a monocytic leukemia, EM-2 and LAMA-84, bcr-abl-positve myeloid leukemia, but not in SD-1, a bcr-abl-positive acute lymphoblastic leukemia (pre B-ALL), RPMI-8226, a multiple myeloma and BV-173, a bcr-abl-positive B-cell line (Figures 1A and 5D).
T104 13716-13872 Sentence denotes After sequencing of the IRF-4 promoter, it could be excluded that absence of IRF-4 expression in any of the above cell lines was due to genetic aberrations.
T105 13873-14045 Sentence denotes However, 2 bp changes (nucleotide −1081, T→C and −1068, A→C) could be detected in both the IRF-4-positive BV-173 and the IRF-4-negative LAMA-84, EM-2 and K-562 (Figure 1B).
T106 14046-14251 Sentence denotes At position −116 an A→C substitution was found in EM-2, K-562 and CML-T1, whereas Jurkat, BV-173 and SD-1 exhibited a mixed A/C sequence and U-937, LAMA-84 and RPMI-8226 no substitution at all (Figure 1B).
T107 14252-14324 Sentence denotes Consequently, these alterations are unlikely to affect IRF-4 expression.
T108 14326-14407 Sentence denotes Increase of IRF-4 expression in hematopoietic cells after demethylating treatment
T109 14408-14515 Sentence denotes We next analyzed whether promoter methylation could be responsible for down-regulation of IRF-4 expression.
T110 14516-14622 Sentence denotes A region including exon1 in the IRF-4 promoter exhibited a large number of CpG-rich sequences (Figure 3A).
T111 14623-14819 Sentence denotes Several chemical substances such as 5-aza-2-deoxycytidine (AzadC) or 5-azacytidine (AzaC) inhibit de novo and maintenance methylation, and thus can be used to discern promoter methylation (32,33).
T112 14820-14863 Sentence denotes We used AzadC to generate unmethylated DNA.
T113 14864-15047 Sentence denotes A 72 h AzadC-treatment resulted in a concentration-dependent activation of IRF-4 transcription in Jurkat and CML-T1 T-cells as well as in U-937, K-562 and EM-2 cell lines (Figure 2A).
T114 15048-15215 Sentence denotes IRF-4 transcription was induced in a time-dependent manner and was observed as early as 24 h after treatment with AzadC and increased over time until 72 h (Figure 2B).
T115 15216-15366 Sentence denotes Time and strength of the appearance of IRF-4 transcripts varied among cell lines, i.e. CML-T1 responded strongest to AzadC-treatment (data not shown).
T116 15367-15502 Sentence denotes In line with this, AzadC-treatment of CML-T1 and LAMA-84 cells also translated in an induction of IRF-4 protein expression (Figure 2C).
T117 15503-15642 Sentence denotes Accordingly, treatment of the IRF-4-positive cell line BV-173, SD-1 and RPMI-8226 with AzadC had no effect on IRF-4 expression (Figure 2D).
T118 15643-15784 Sentence denotes There was no difference in the effects of AzaC versus AzadC, as both increased the IRF-4 mRNA level in CML-T1 cells as well (data not shown).
T119 15785-15970 Sentence denotes This implied that promoter methylation may control IRF-4 expression, but an alternative explanation may be activation of positive transcriptional regulators of IRF-4 by AzadC (or AzaC).
T120 15972-16072 Sentence denotes Methylation-sensitive enzymes do not cut specific sites in the IRF-4 promoter in hematopoietic cells
T121 16073-16312 Sentence denotes To further investigate promoter methylation as a regulatory mechanism of IRF-4 gene expression, restriction-PCR-assays were performed (20,24), where only methylated DNA would not be cut enabling subsequent PCR amplification and vice versa.
T122 16313-16490 Sentence denotes Genomic DNA from leukemic cells Jurkat, CML-T1, U-937, K-562, EM-2 and BV-173 was digested with the methylation-sensitive enzymes HpaII, Bsh1236I and HaeII-isochizomer Bsp143II.
T123 16491-16616 Sentence denotes EcoRI, which has no recognition site within the IRF-4 promoter, and the methylation-resistant enzyme MspI served as controls.
T124 16617-16718 Sentence denotes Two separate amplification reactions were performed, generating two fragments, F1 and F2 (Figure 3A).
T125 16719-17005 Sentence denotes After digestion with HpaII and Bsp143II a sufficient PCR amplification of F1 and F2 was detected in DNA from IRF-4-negative Jurkat, CML-T1, U-937, K-562 and EM-2 cells, suggesting a promoter methylation (and restriction protection) at the respective recognition sites (Figure 3B and C).
T126 17006-17141 Sentence denotes Notably, in IRF-4-positive SD-1 cells digestion with the methylation-sensitive enzymes completely inhibited amplification of F1 and F2.
T127 17142-17338 Sentence denotes In IRF-4-positive BV-173 cells a HpaII, but not a Bsh1236I digestion, significantly reduced the amplifiable DNA message of F2 (Figure 3C), whereas amplification of F1 was not affected (Figure 3B).
T128 17339-17534 Sentence denotes This implied that IRF-4 transcription in SD-1 and BV-173 cells is associated with less promoter methylation (in BV-173 especially at HpaII sites) as compared with the tested IRF-4-negative cells.
T129 17536-17614 Sentence denotes Specific CpG sites in the IRF-4 promoter are methylated in hematopoietic cells
T130 17615-17946 Sentence denotes In order to exactly map the methylation sites within the IRF-4 promoter, we treated DNA of Jurkat, CML-T1, U-937, K-562 and EM-2 cells as well as of SD-1, RPMI-8226 and BV-173 control cells with bisulfite, which chemically converts unmethylated cytosine to uracil, whereas it has no effect on methylated cytosine, i.e. in CpG (34).
T131 17947-18029 Sentence denotes This technique is especially useful for detection of unknown methylation patterns.
T132 18030-18209 Sentence denotes PCR amplification, cloning and sequencing of the bisulfite-treated DNA showed a specific methylation pattern of the analyzed 62 CpG sites in all cell lines (Figure 4 and Table 1).
T133 18210-18409 Sentence denotes In general, the methylational status ranged from one cell line with a nearly non-methylated IRF-4 promoter (SD-1, IRF-4-positive) to a completely methylated IRF-4 promoter in CML-T1 (IRF-4-negative).
T134 18410-18604 Sentence denotes Interestingly, the percentage of CpG methylation in the IRF-4 promoter from IRF-4-positive cells was very low (mean 24%) as compared with IRF-4-negative cells (mean 94%) (Figure 4A and Table 1).
T135 18605-18971 Sentence denotes A 5′-region (R1) with 13 hypermethylated CpG sites (mean number of methylated clones 5.5 of 8 with 77% methylated CpGs) was found in most cells (except SD-1 and RPMI-8226) and a 3′-region (R3) of 6 hypomethylated CpG sites (mean number of methylated clones 1.7 of 8 with 33% methylated CpGs) was found in most cells (except CML-T1 and U-937) (Figure 4A and Table 1).
T136 18972-19249 Sentence denotes Intriguingly, a stretch of 13 CpG sites (#10–22; R2) was detected in between these regions, which were highly methylated in IRF-4-negative (mean number of methylated clones 7.1 of 8 with 89% methylated CpGs) but totally non-methylated in IRF-4-positive cells (Figure 4A and B).
T137 19250-19443 Sentence denotes Furthermore, three CpG sites at the 5′ end (#54, 56, 58) and two CpG motifs at the 3′ end (#1, 2) showed this direct correlation between high methylation status and absence of IRF-4 expression.
T138 19444-19620 Sentence denotes In addition, two CpG sites located in a NFκB (#48) and a SP1 element (#45) are less methylated in IRF-4-positive than in IRF-4-negative cells (mean number of methylated clones:
T139 19621-19637 Sentence denotes 1/8 versus 8/8).
T140 19638-19752 Sentence denotes These results indicate the involvement of CpG methylation in the regulation of IRF-4 expression in leukemic cells.
T141 19754-19837 Sentence denotes In vitro methylation of an IRF-4 promoter-reporter construct decreases its activity
T142 19838-20038 Sentence denotes To provide evidence for a direct effect of methylational status on IRF-4 promoter activity we performed reporter gene assays with IRF-4 promoter constructs before and after their in vitro methylation.
T143 20039-20170 Sentence denotes A complete methylation of these constructs was checked via restriction assays with methylation-sensitive endonucleases (Figure 5A).
T144 20171-20311 Sentence denotes Intriguingly, methylation of the IRF-4 promoter significantly decreased promoter activity in IRF-4-positive SD-1 cells by 85.0% (Figure 5B).
T145 20312-20513 Sentence denotes The silencing effect of CpG methylation was not restricted to IRF-4-positive cells, since in vitro methylation led to a 92.9% abrogation of promoter activity in IRF-4-negative Jurkat cells (Figure 5C).
T146 20514-20687 Sentence denotes In contrast, control methylation of a reporter construct with a different promoter (FasL) as well as an empty vector had no effect on the reporter activity (data not shown).
T147 20688-20782 Sentence denotes These data proved a direct association between methylation and activity of the IRF-4 promoter.
T148 20784-20911 Sentence denotes mRNA expression of DNA methyltransferases and methyl-CpG-binding proteins may not be associated with IRF-4 promoter methylation
T149 20912-21138 Sentence denotes Since abundance of DNMT and MBP contribute to promoter regulation via methylation (25,26,28), we studied their mRNA expression to investigate a possible mechanism for the observed methylation differences in the IRF-4 promoter.
T150 21139-21336 Sentence denotes To this end, we did not detect a significant difference in DNMT (DNMT1, DNMT3A and DNMT3B) or MBP (MBD1, MBD2, MBD4 and MeCP) mRNA expression between IRF-4-positive and -negative cells (Figure 5D).
T151 21337-21492 Sentence denotes In fact, all analyzed cells had moderate to high mRNA levels of these tested DNMT/MBPs and differences in expression were not correlated with IRF-4 status.
T152 21493-21661 Sentence denotes These results indicate a distinct cause of the methylation differences in IRF-4-positive and -negative cells rather than changes in the DNMT and MBP mRNA transcription.
T153 21663-21673 Sentence denotes DISCUSSION
T154 21674-21760 Sentence denotes Many genetic lesions are known to influence gene expression of tumor suppressor genes.
T155 21761-21943 Sentence denotes Whereas mutations and deletions or insertions have permanent effects, reversible mechanisms are gene methylation, or expression and activation of transcription factors, respectively.
T156 21944-22075 Sentence denotes We studied a putative cause for absent IRF-4 expression in leukemia cells and first focused on genetic aberrations of the promoter.
T157 22076-22185 Sentence denotes We observed no genetic alterations in the IRF-4 promoter, which can account for the lack of IRF-4 expression:
T158 22186-22597 Sentence denotes The detected base pair changes at position −1081 (T→C substitution), at position −1068 (A→C substitution) and at position −116 (A→C substitution) are unlikely responsible for absent IRF-4-expression since the first two mutations were found both in IRF-4-positive and -negative cells whereas the latter change was not detected consistently in all IRF-4-negative or -positive cells and may thus be a polymorphism.
T159 22598-22787 Sentence denotes All three substitutions did not change any known putative transcription factor binding sites (30,31) and also do not affect any restriction sites or primer binding sites of the used assays.
T160 22788-22956 Sentence denotes However, permanent genetic variations in the IRF-4 coding sequence, such as deletions or mutations resulting in stop-codons have not been excluded by sequence analysis.
T161 22957-23139 Sentence denotes Since IRF-4 expression in cell lines and CML can be induced by demethylation and successful IFN-α therapy (3), respectively, the existence of such genetic aberrations seems unlikely.
T162 23140-23459 Sentence denotes We then investigated whether the previously described down-regulation of IRF-4 expression in human myeloid leukemias was due to a differential hypermethylation of the promoter, since the presented re-expression due to AzadC-treatment might also be a result of activation of positive transcriptional regulators of IRF-4.
T163 23460-23641 Sentence denotes Methylation of CpG sites is a common mechanism of silencing genes in leukemia and has also been shown for another IRF, IRF-7 (35) and for PU.1 (36), an interacting partner of IRF-4.
T164 23642-23844 Sentence denotes To elucidate the relevance of this mechanism for the regulation of IRF-4 expression, various leukemic cells were treated with demethylating agents and promoters were sequenced after bisulfite treatment.
T165 23845-23973 Sentence denotes We found that IRF-4 expression could indeed be connected to the methylation status of distinct CpG motifs in the IRF-4 promoter.
T166 23974-24124 Sentence denotes In Figure 4A, those CpG sites are shown (bottom line), whose hypermethylation may account for the absence of IRF-4 expression in the respective cells.
T167 24125-24251 Sentence denotes One of them (#54) is adjacent to an identified regulatory element (NFκB-site), indicating a possible involvement of this site.
T168 24252-24372 Sentence denotes At two further CpG sites (#48, 45) the methylation status in IRF-4-positive was lower than that of IRF-4-negative cells.
T169 24373-24500 Sentence denotes These CpG sites are located in an NFκB and an SP1 element (31) and thus may also play a role in regulation of IRF-4 expression.
T170 24501-24695 Sentence denotes It has been shown that NFκB elements play an important role in IRF-4 induction as IRF-4 expression depends on binding of the transactivator c-Rel to these elements in the IRF-4 promoter (31,37).
T171 24696-24918 Sentence denotes Furthermore, methylation of the central CpG in the NFκB element inhibits binding of the NFκB protein complexes (38), promoting the significance of the observed methylation differences in IRF-4-positive and -negative cells.
T172 24919-25117 Sentence denotes Via in vitro methylation and reporter gene assays we could clearly appoint the silencing of the IRF-4 promoter to a methylation effect, which may thus be the mechanism of IRF-4 deregulation in vivo.
T173 25118-25246 Sentence denotes One possible cause for the aberrant methylation in tumorigenesis is an increased level of DNMTs during the pathogenetic process.
T174 25247-25363 Sentence denotes In colon, lung and hematologic malignancies, overexpression of DNMT1, a maintenance DNMT, has been detected (39–41).
T175 25364-25594 Sentence denotes Furthermore, it has been shown that CML cells in the acute phase exhibited elevated levels of the three known DNMTs, while CML cells in chronic phase expressed normal levels of DNMTs if compared with normal bone marrow cells (25).
T176 25595-25728 Sentence denotes Interestingly, a positive correlation between DNMT1 expression levels and hypermethylation of p15INK4b has been detected in AML (25).
T177 25729-25939 Sentence denotes In this work, we did not detect significant mRNA expression differences of selected DNMT or MBP, making it an unlikely cause for the observed methylation and thus IRF-4 expression differences in leukemia cells.
T178 25940-26117 Sentence denotes The finding that IRF-4 expression is silenced by promoter hypermethylation might represent a mechanism that accounts for the previously observed loss of IRF-4 expression in CML.
T179 26118-26310 Sentence denotes Indeed, several clinical trials with leukemia patients and patients with myelodysplastic syndromes demonstrated the potential clinical benefit of a treatment with demethylating agents (42–45).
T180 26311-26455 Sentence denotes The expression of another IRF, IFN consensus sequence binding protein (ICSBP/IRF-8), is impaired in myeloid leukemias especially CML (27,46,47).
T181 26456-26704 Sentence denotes But in contrast to IRF-4, the loss of this IRF could not be reverted in ICSBP-negative cell lines (EM-2, CML-T1, K-562 and LAMA-84) by treatment with AzadC (Figure 6) and AzadC has no effect on ICSBP levels in ICSBP-positive U-937 cells (Figure 6).
T182 26705-26775 Sentence denotes These data suggest a distinct regulatory mechanism for these two IRFs.
T183 26776-27038 Sentence denotes IRF-4, similar to many other classical tumor suppressor genes p15INK4b, p16INK4a or p53, may thus be a subject of alterations in the promoter methylation status leading to expression changes, which might contribute to the initiation and/or progression of cancer.
T184 27039-27178 Sentence denotes Still, the obvious functional diversity of IRF-4 remains remarkable and cannot be fully explained by the IRF-4 promoter methylation status.
T185 27179-27244 Sentence denotes For example, IRF-4 is primarily known for its oncogenic features.
T186 27245-27446 Sentence denotes In multiple myeloma (MM) a translocation on chromosome 14q was reported to lead to a fusion gene of immunoglobulin heavy-chain (IgH) and IRF-4 resulting in a subsequent overexpression of IRF-4 (48,49).
T187 27447-27680 Sentence denotes In addition, abundant IRF-4 expression was found to be a marker for various subsets of lymphomas, such as diffuse large B-cell lymphomas, primary effusion lymphoma, and marginal zone lymphoma, and adult T-cell leukemia (11,31,50–52).
T188 27681-27736 Sentence denotes This draws a more complex picture of the role of IRF-4.
T189 27737-27976 Sentence denotes Down-regulation of IRF-4 may promote leukemogenesis in myeloid cell context (3), which was recently confirmed in IRF-4−/− ICSBP−/− double knock-out mice (53), while IRF-4 up-regulation may induce a growth advantage in lymphomas or MM (48).
T190 27977-28193 Sentence denotes Taken together, our data suggest that IRF-4 promoter methylation regulates IRF-4 expression, and that aberrant expression of IRF-4 in certain types of leukemia may be a consequence of IRF-4 promoter hypermethylation.

2_test

Id Subject Object Predicate Lexical cue
16396836-8605319-76538161 2077-2078 8605319 denotes 1
16396836-10219069-76538162 2079-2080 10219069 denotes 2
16396836-10219069-76538163 2259-2260 10219069 denotes 2
16396836-8605319-76538164 2414-2415 8605319 denotes 1
16396836-10219069-76538165 2416-2417 10219069 denotes 2
16396836-11013272-76538166 2571-2572 11013272 denotes 3
16396836-9620643-76538167 2932-2933 9620643 denotes 4
16396836-10936058-76538167 2932-2933 10936058 denotes 4
16396836-11244049-76538167 2932-2933 11244049 denotes 4
16396836-7797077-76538168 3087-3088 7797077 denotes 7
16396836-7541907-76538168 3087-3088 7541907 denotes 7
16396836-8657101-76538168 3087-3088 8657101 denotes 7
16396836-11846983-76538168 3087-3088 11846983 denotes 7
16396836-11846982-76538168 3087-3088 11846982 denotes 7
16396836-11846983-76538169 3265-3267 11846983 denotes 10
16396836-11846982-76538170 3268-3270 11846982 denotes 11
16396836-8999800-76538171 3444-3446 8999800 denotes 12
16396836-11013272-76538172 3529-3530 11013272 denotes 3
16396836-8982461-76538173 3839-3841 8982461 denotes 13
16396836-10361102-76538174 3842-3844 10361102 denotes 14
16396836-9639410-76538175 4121-4123 9639410 denotes 15
16396836-10729832-76538175 4121-4123 10729832 denotes 15
16396836-11748635-76538175 4121-4123 11748635 denotes 15
16396836-11748635-76538176 4232-4234 11748635 denotes 17
16396836-9041182-76538176 4232-4234 9041182 denotes 17
16396836-12154405-76538176 4232-4234 12154405 denotes 17
16396836-7938018-76538177 4331-4333 7938018 denotes 20
16396836-8822945-76538177 4331-4333 8822945 denotes 20
16396836-10068681-76538177 4331-4333 10068681 denotes 20
16396836-10498618-76538177 4331-4333 10498618 denotes 20
16396836-9389709-76538178 4446-4448 9389709 denotes 24
16396836-11222358-76538179 4681-4683 11222358 denotes 25
16396836-10454587-76538180 4893-4895 10454587 denotes 26
16396836-9414265-76538181 7047-7049 9414265 denotes 27
16396836-11013272-76538182 7183-7184 11013272 denotes 3
16396836-9414265-76538183 7185-7187 9414265 denotes 27
16396836-12101420-76538184 7384-7386 12101420 denotes 28
16396836-14656881-76538185 7502-7504 14656881 denotes 29
16396836-7938018-76538186 9062-9064 7938018 denotes 20
16396836-9389709-76538187 9065-9067 9389709 denotes 24
16396836-8921401-76538188 9456-9458 8921401 denotes 30
16396836-11013272-76538189 9762-9763 11013272 denotes 3
16396836-12218129-76538190 12185-12187 12218129 denotes 31
16396836-14656881-76538191 12485-12487 14656881 denotes 29
16396836-11013272-76538192 13252-13253 11013272 denotes 3
16396836-6156004-76538193 14812-14814 6156004 denotes 32
16396836-2578884-76538194 14815-14817 2578884 denotes 33
16396836-7938018-76538195 16208-16210 7938018 denotes 20
16396836-9389709-76538196 16211-16213 9389709 denotes 24
16396836-10361102-76538197 17942-17944 10361102 denotes 34
16396836-11222358-76538198 20995-20997 11222358 denotes 25
16396836-10454587-76538199 20998-21000 10454587 denotes 26
16396836-12101420-76538200 21001-21003 12101420 denotes 28
16396836-8921401-76538201 22692-22694 8921401 denotes 30
16396836-12218129-76538202 22695-22697 12218129 denotes 31
16396836-11013272-76538203 23064-23065 11013272 denotes 3
16396836-10924517-76538204 23586-23588 10924517 denotes 35
16396836-10619599-76538205 23604-23606 10619599 denotes 36
16396836-12218129-76538206 24432-24434 12218129 denotes 31
16396836-12218129-76538207 24688-24690 12218129 denotes 31
16396836-10770796-76538208 24691-24693 10770796 denotes 37
16396836-1768651-76538209 24808-24810 1768651 denotes 38
16396836-8331684-76538210 25356-25358 8331684 denotes 39
16396836-8633014-76538210 25356-25358 8633014 denotes 39
16396836-9529124-76538210 25356-25358 9529124 denotes 39
16396836-11222358-76538211 25590-25592 11222358 denotes 25
16396836-11222358-76538212 25724-25726 11222358 denotes 25
16396836-11281740-76538213 26303-26305 11281740 denotes 42
16396836-12154409-76538213 26303-26305 12154409 denotes 42
16396836-14669283-76538213 26303-26305 14669283 denotes 42
16396836-14604977-76538213 26303-26305 14604977 denotes 42
16396836-9414265-76538214 26445-26447 9414265 denotes 27
16396836-8861914-76538215 26448-26450 8861914 denotes 46
16396836-11369663-76538216 26451-26453 11369663 denotes 47
16396836-10557056-76538217 27442-27444 10557056 denotes 49
16396836-11846982-76538218 27667-27669 11846982 denotes 11
16396836-12218129-76538219 27670-27672 12218129 denotes 31
16396836-10676951-76538220 27673-27675 10676951 denotes 50
16396836-10720141-76538220 27673-27675 10720141 denotes 50
16396836-11157493-76538220 27673-27675 11157493 denotes 50
16396836-11013272-76538221 27814-27815 11013272 denotes 3

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T129 0-15 NN denotes Down-regulation
T130 16-18 IN denotes of
T131 19-29 NN denotes interferon
T132 30-40 JJ denotes regulatory
T133 41-47 NN denotes factor
T134 48-49 CD denotes 4
T135 50-54 NN denotes gene
T136 55-65 NN denotes expression
T137 66-68 IN denotes in
T138 69-77 JJ denotes leukemic
T139 78-83 NN denotes cells
T140 84-87 JJ denotes due
T141 88-90 TO denotes to
T142 91-107 NN denotes hypermethylation
T143 108-110 IN denotes of
T144 111-114 NN denotes CpG
T145 115-121 NN denotes motifs
T146 122-124 IN denotes in
T147 125-128 DT denotes the
T148 129-137 NN denotes promoter
T149 138-144 NN denotes region
T150 156-164 IN denotes Although
T151 165-168 DT denotes the
T152 169-176 NN denotes bcr-abl
T153 177-190 NN denotes translocation
T154 191-194 VB denotes has
T155 195-199 VB denotes been
T156 200-205 VB denotes shown
T157 206-208 TO denotes to
T158 209-211 VB denotes be
T159 212-215 DT denotes the
T160 216-225 JJ denotes causative
T161 226-233 JJ denotes genetic
T162 234-244 NN denotes aberration
T163 245-247 IN denotes in
T164 248-255 JJ denotes chronic
T165 256-263 JJ denotes myeloid
T166 264-272 NN denotes leukemia
T167 273-274 -LRB- denotes (
T168 274-277 NN denotes CML
T169 277-278 -RRB- denotes )
T170 278-279 -COMMA- denotes ,
T171 280-285 EX denotes there
T172 286-288 VB denotes is
T173 289-297 VB denotes mounting
T174 298-306 NN denotes evidence
T175 307-311 IN denotes that
T176 312-315 DT denotes the
T177 316-328 NN denotes deregulation
T178 329-331 IN denotes of
T179 332-337 JJ denotes other
T180 338-343 NN denotes genes
T181 343-344 -COMMA- denotes ,
T182 345-349 JJ denotes such
T183 350-352 IN denotes as
T184 353-356 DT denotes the
T185 357-370 NN denotes transcription
T186 371-377 NN denotes factor
T187 378-388 NN denotes interferon
T188 389-399 JJ denotes regulatory
T189 400-406 NN denotes factor
T190 407-408 CD denotes 4
T191 409-410 -LRB- denotes (
T192 410-415 NN denotes IRF-4
T193 415-416 -RRB- denotes )
T194 416-417 -COMMA- denotes ,
T195 418-420 VB denotes is
T196 421-425 RB denotes also
T197 426-436 VB denotes implicated
T198 437-439 IN denotes in
T199 440-443 DT denotes the
T200 444-456 NN denotes pathogenesis
T201 457-459 IN denotes of
T202 460-463 NN denotes CML
T203 465-473 NN denotes Promoter
T204 474-485 NN denotes methylation
T205 486-488 IN denotes of
T206 489-492 NN denotes CpG
T207 493-499 NN denotes target
T208 500-505 NN denotes sites
T209 506-508 CC denotes or
T210 509-515 JJ denotes direct
T211 516-536 NN denotes deletions/insertions
T212 537-539 IN denotes of
T213 540-545 NN denotes genes
T214 546-549 VB denotes are
T215 550-560 NN denotes mechanisms
T216 561-563 IN denotes of
T217 564-565 DT denotes a
T218 566-576 JJ denotes reversible
T219 577-579 CC denotes or
T220 580-589 JJ denotes permanent
T221 590-599 NN denotes silencing
T222 600-602 IN denotes of
T223 603-607 NN denotes gene
T224 608-618 NN denotes expression
T225 618-619 -COMMA- denotes ,
T226 620-632 RB denotes respectively
T227 634-643 RB denotes Therefore
T228 643-644 -COMMA- denotes ,
T229 645-647 PRP denotes we
T230 648-660 VB denotes investigated
T231 661-668 IN denotes whether
T232 669-674 NN denotes IRF-4
T233 675-683 NN denotes promoter
T234 684-695 NN denotes methylation
T235 696-698 CC denotes or
T236 699-707 NN denotes mutation
T237 708-711 MD denotes may
T238 712-714 VB denotes be
T239 715-723 VB denotes involved
T240 724-726 IN denotes in
T241 727-730 DT denotes the
T242 731-741 NN denotes regulation
T243 742-744 IN denotes of
T244 745-750 NN denotes IRF-4
T245 751-761 NN denotes expression
T246 762-764 IN denotes in
T247 765-773 NN denotes leukemia
T248 774-779 NN denotes cells
T249 781-788 IN denotes Whereas
T250 789-797 NN denotes promoter
T251 798-807 NN denotes mutations
T252 808-810 CC denotes or
T253 811-821 JJ denotes structural
T254 822-836 NN denotes rearrangements
T255 837-842 MD denotes could
T256 843-845 VB denotes be
T257 846-854 VB denotes excluded
T258 855-857 IN denotes as
T259 858-859 DT denotes a
T260 860-865 NN denotes cause
T261 866-868 IN denotes of
T262 869-876 VB denotes altered
T263 877-882 NN denotes IRF-4
T264 883-893 NN denotes expression
T265 894-896 IN denotes in
T266 897-910 JJ denotes hematopoietic
T267 911-916 NN denotes cells
T268 916-917 -COMMA- denotes ,
T269 918-921 DT denotes the
T270 922-927 NN denotes IRF-4
T271 928-936 NN denotes promoter
T272 937-948 NN denotes methylation
T273 949-955 NN denotes status
T274 956-959 VB denotes was
T275 960-965 VB denotes found
T276 966-968 TO denotes to
T277 969-982 RB denotes significantly
T278 983-992 VB denotes influence
T279 993-998 NN denotes IRF-4
T280 999-1012 NN denotes transcription
T281 1014-1019 RB denotes First
T282 1019-1020 -COMMA- denotes ,
T283 1021-1030 NN denotes treatment
T284 1031-1033 IN denotes of
T285 1034-1048 JJ denotes IRF-4-negative
T286 1049-1057 JJ denotes lymphoid
T287 1057-1058 -COMMA- denotes ,
T288 1059-1066 JJ denotes myeloid
T289 1067-1070 CC denotes and
T290 1071-1080 JJ denotes monocytic
T291 1081-1085 NN denotes cell
T292 1086-1091 NN denotes lines
T293 1092-1096 IN denotes with
T294 1097-1100 DT denotes the
T295 1101-1122 NN denotes methylation-inhibitor
T296 1123-1144 NN denotes 5-aza-2-deoxycytidine
T297 1145-1153 VB denotes resulted
T298 1154-1156 IN denotes in
T299 1157-1158 DT denotes a
T300 1159-1164 NN denotes time-
T301 1165-1168 CC denotes and
T302 1169-1192 JJ denotes concentration-dependent
T303 1193-1201 NN denotes increase
T304 1202-1204 IN denotes of
T305 1205-1210 NN denotes IRF-4
T306 1211-1215 NN denotes mRNA
T307 1216-1219 CC denotes and
T308 1220-1227 NN denotes protein
T309 1228-1234 NN denotes levels
T310 1236-1242 RB denotes Second
T311 1242-1243 -COMMA- denotes ,
T312 1244-1249 VB denotes using
T313 1250-1251 DT denotes a
T314 1252-1273 NN denotes restriction-PCR-assay
T315 1274-1277 CC denotes and
T316 1278-1298 NN denotes bisulfite-sequencing
T317 1299-1301 PRP denotes we
T318 1302-1312 VB denotes identified
T319 1313-1325 RB denotes specifically
T320 1326-1336 VB denotes methylated
T321 1337-1340 NN denotes CpG
T322 1341-1346 NN denotes sites
T323 1347-1349 IN denotes in
T324 1350-1364 JJ denotes IRF-4-negative
T325 1365-1368 CC denotes but
T326 1369-1372 RB denotes not
T327 1373-1375 IN denotes in
T328 1376-1390 JJ denotes IRF-4-positive
T329 1391-1396 NN denotes cells
T330 1398-1403 RB denotes Third
T331 1403-1404 -COMMA- denotes ,
T332 1405-1407 PRP denotes we
T333 1408-1415 RB denotes clearly
T334 1416-1426 VB denotes determined
T335 1427-1435 NN denotes promoter
T336 1436-1447 NN denotes methylation
T337 1448-1450 IN denotes as
T338 1451-1452 DT denotes a
T339 1453-1462 NN denotes mechanism
T340 1463-1466 IN denotes for
T341 1467-1472 NN denotes IRF-4
T342 1473-1488 NN denotes down-regulation
T343 1489-1492 IN denotes via
T344 1493-1501 NN denotes reporter
T345 1502-1506 NN denotes gene
T346 1507-1513 NN denotes assays
T347 1513-1514 -COMMA- denotes ,
T348 1515-1518 CC denotes but
T349 1519-1522 VB denotes did
T350 1523-1526 RB denotes not
T351 1527-1533 VB denotes detect
T352 1534-1536 DT denotes an
T353 1537-1548 NN denotes association
T354 1549-1551 IN denotes of
T355 1552-1565 JJ denotes methylational
T356 1566-1572 NN denotes status
T357 1573-1576 CC denotes and
T358 1577-1581 NN denotes mRNA
T359 1582-1592 NN denotes expression
T360 1593-1595 IN denotes of
T361 1596-1599 NN denotes DNA
T362 1600-1618 NN denotes methyltransferases
T363 1619-1621 CC denotes or
T364 1622-1640 JJ denotes methyl-CpG-binding
T365 1641-1649 NN denotes proteins
T366 1651-1659 RB denotes Together
T367 1659-1660 -COMMA- denotes ,
T368 1661-1666 DT denotes these
T369 1667-1671 NN denotes data
T370 1672-1679 VB denotes suggest
T371 1680-1683 NN denotes CpG
T372 1684-1697 JJ denotes site-specific
T373 1698-1703 NN denotes IRF-4
T374 1704-1712 NN denotes promoter
T375 1713-1724 NN denotes methylation
T376 1725-1727 IN denotes as
T377 1728-1729 DT denotes a
T378 1730-1738 JJ denotes putative
T379 1739-1748 NN denotes mechanism
T380 1749-1751 IN denotes of
T381 1752-1766 VB denotes down-regulated
T382 1767-1772 NN denotes IRF-4
T383 1773-1783 NN denotes expression
T384 1784-1786 IN denotes in
T385 1787-1795 NN denotes leukemia
T1104 1811-1818 JJ denotes Chronic
T1105 1819-1826 JJ denotes myeloid
T1106 1827-1835 NN denotes leukemia
T1107 1836-1837 -LRB- denotes (
T1108 1837-1840 NN denotes CML
T1109 1840-1841 -RRB- denotes )
T1110 1842-1844 VB denotes is
T1111 1845-1846 DT denotes a
T1112 1847-1853 JJ denotes clonal
T1113 1854-1872 JJ denotes myeloproliferative
T1114 1873-1881 NN denotes disorder
T1115 1882-1886 IN denotes with
T1116 1887-1888 DT denotes a
T1117 1889-1896 JJ denotes typical
T1118 1897-1902 CD denotes three
T1119 1903-1909 JJ denotes phased
T1120 1910-1916 NN denotes course
T1121 1917-1918 -LRB- denotes (
T1122 1918-1925 JJ denotes chronic
T1123 1925-1926 -COMMA- denotes ,
T1124 1927-1938 JJ denotes accelerated
T1125 1939-1942 CC denotes and
T1126 1943-1950 JJ denotes blastic
T1127 1951-1956 NN denotes phase
T1128 1956-1957 -RRB- denotes )
T1129 1958-1968 VB denotes reflecting
T1130 1969-1972 DT denotes the
T1131 1973-1977 NN denotes loss
T1132 1978-1980 IN denotes of
T1133 1981-1996 NN denotes differentiation
T1134 1997-2000 CC denotes and
T1135 2001-2010 JJ denotes malignant
T1136 2011-2019 NN denotes progress
T1137 2020-2025 WDT denotes which
T1138 2026-2036 RB denotes inevitably
T1139 2037-2042 VB denotes leads
T1140 2043-2045 TO denotes to
T1141 2046-2051 NN denotes death
T1142 2052-2057 IN denotes after
T1143 2058-2061 DT denotes the
T1144 2062-2069 JJ denotes blastic
T1145 2070-2075 NN denotes phase
T1146 2076-2077 -LRB- denotes (
T1147 2077-2080 CD denotes 1,2
T1148 2080-2081 -RRB- denotes )
T1149 2083-2086 DT denotes The
T1150 2087-2095 NN denotes hallmark
T1151 2096-2103 JJ denotes genetic
T1152 2104-2114 NN denotes aberration
T1153 2115-2117 IN denotes of
T1154 2118-2121 NN denotes CML
T1155 2122-2124 VB denotes is
T1156 2125-2126 DT denotes a
T1157 2127-2137 JJ denotes reciprocal
T1158 2138-2149 JJ denotes chromosomal
T1159 2150-2163 NN denotes translocation
T1160 2164-2165 NN denotes t
T1161 2165-2166 -LRB- denotes (
T1162 2166-2167 CD denotes 9
T1163 2167-2168 -COLON- denotes ;
T1164 2168-2170 CD denotes 22
T1165 2170-2171 -RRB- denotes )
T1166 2172-2179 VB denotes leading
T1167 2180-2182 TO denotes to
T1168 2183-2193 NN denotes expression
T1169 2194-2196 IN denotes of
T1170 2197-2198 DT denotes a
T1171 2199-2206 NN denotes bcr-abl
T1172 2207-2213 NN denotes fusion
T1173 2214-2218 NN denotes gene
T1174 2218-2219 -COMMA- denotes ,
T1175 2220-2222 DT denotes an
T1176 2223-2231 JJ denotes aberrant
T1177 2232-2241 VB denotes activated
T1178 2242-2250 NN denotes tyrosine
T1179 2251-2257 NN denotes kinase
T1180 2258-2259 -LRB- denotes (
T1181 2259-2260 CD denotes 2
T1182 2260-2261 -RRB- denotes )
T1183 2263-2272 NN denotes Treatment
T1184 2273-2277 IN denotes with
T1185 2278-2288 NN denotes interferon
T1186 2289-2290 NN denotes α
T1187 2291-2292 -LRB- denotes (
T1188 2292-2297 NN denotes IFN-α
T1189 2297-2298 -RRB- denotes )
T1190 2299-2307 VB denotes prolongs
T1191 2308-2316 NN denotes survival
T1192 2317-2319 IN denotes of
T1193 2320-2323 NN denotes CML
T1194 2324-2332 NN denotes patients
T1195 2333-2336 CC denotes and
T1196 2337-2339 VB denotes is
T1197 2340-2350 VB denotes associated
T1198 2351-2355 IN denotes with
T1199 2356-2357 DT denotes a
T1200 2358-2366 JJ denotes complete
T1201 2367-2378 JJ denotes cytogenetic
T1202 2379-2387 NN denotes response
T1203 2388-2390 IN denotes in
T1204 2391-2395 CD denotes 5–33
T1205 2395-2396 NN denotes %
T1206 2397-2399 IN denotes of
T1207 2400-2403 NN denotes CML
T1208 2404-2412 NN denotes patients
T1209 2413-2414 -LRB- denotes (
T1210 2414-2417 CD denotes 1,2
T1211 2417-2418 -RRB- denotes )
T1212 2420-2428 RB denotes Recently
T1213 2428-2429 -COMMA- denotes ,
T1214 2430-2432 PRP denotes we
T1215 2433-2442 VB denotes described
T1216 2443-2445 DT denotes an
T1217 2446-2454 JJ denotes impaired
T1218 2455-2465 NN denotes expression
T1219 2466-2468 IN denotes of
T1220 2469-2472 DT denotes the
T1221 2473-2483 NN denotes interferon
T1222 2484-2494 JJ denotes regulatory
T1223 2495-2501 NN denotes factor
T1224 2502-2503 CD denotes 4
T1225 2504-2505 -LRB- denotes (
T1226 2505-2510 NN denotes IRF-4
T1227 2510-2511 -RRB- denotes )
T1228 2512-2514 IN denotes in
T1229 2515-2518 NN denotes CML
T1230 2518-2519 -COMMA- denotes ,
T1231 2520-2531 VB denotes correlating
T1232 2532-2536 IN denotes with
T1233 2537-2541 JJ denotes poor
T1234 2542-2550 NN denotes response
T1235 2551-2553 TO denotes to
T1236 2554-2559 NN denotes IFN-α
T1237 2560-2569 NN denotes treatment
T1238 2570-2571 -LRB- denotes (
T1239 2571-2572 CD denotes 3
T1240 2572-2573 -RRB- denotes )
T1241 2575-2578 DT denotes The
T1242 2579-2584 NN denotes cause
T1243 2585-2587 IN denotes of
T1244 2588-2591 DT denotes the
T1245 2592-2601 NN denotes silencing
T1246 2602-2604 IN denotes of
T1247 2605-2610 NN denotes IRF-4
T1248 2611-2616 NN denotes level
T1249 2617-2625 VB denotes remained
T1250 2626-2633 JJ denotes unclear
T1251 2635-2645 NN denotes Interferon
T1252 2646-2656 JJ denotes regulatory
T1253 2657-2664 NN denotes factors
T1254 2665-2666 -LRB- denotes (
T1255 2666-2670 NN denotes IRFs
T1256 2670-2671 -RRB- denotes )
T1257 2672-2675 VB denotes are
T1258 2676-2677 DT denotes a
T1259 2678-2684 NN denotes family
T1260 2685-2687 IN denotes of
T1261 2688-2703 JJ denotes transcriptional
T1262 2704-2714 NN denotes regulators
T1263 2715-2722 VB denotes defined
T1264 2723-2725 IN denotes by
T1265 2726-2727 DT denotes a
T1266 2728-2742 JJ denotes characteristic
T1267 2743-2751 NN denotes homology
T1268 2752-2754 IN denotes in
T1269 2755-2760 PRP-DOLLAR- denotes their
T1270 2761-2772 JJ denotes DNA-binding
T1271 2773-2779 NN denotes domain
T1272 2781-2785 PRP denotes They
T1273 2786-2790 VB denotes play
T1274 2791-2793 DT denotes an
T1275 2794-2803 JJ denotes important
T1276 2804-2808 NN denotes role
T1277 2809-2811 IN denotes in
T1278 2812-2815 DT denotes the
T1279 2816-2826 NN denotes regulation
T1280 2827-2829 IN denotes of
T1281 2830-2837 JJ denotes various
T1282 2838-2843 NN denotes genes
T1283 2844-2845 -LRB- denotes (
T1284 2845-2849 JJ denotes such
T1285 2850-2852 IN denotes as
T1286 2853-2857 NN denotes IFNs
T1287 2857-2858 -COMMA- denotes ,
T1288 2859-2871 NN denotes interleukins
T1289 2871-2872 -COMMA- denotes ,
T1290 2873-2876 NN denotes MHC
T1291 2877-2882 NN denotes class
T1292 2883-2887 NN denotes I/II
T1293 2887-2888 -RRB- denotes )
T1294 2888-2889 -COMMA- denotes ,
T1295 2890-2899 NN denotes apoptosis
T1296 2900-2903 CC denotes and
T1297 2904-2930 NN denotes differentiation/maturation
T1298 2931-2932 -LRB- denotes (
T1299 2932-2935 CD denotes 4–6
T1300 2935-2936 -RRB- denotes )
T1301 2938-2943 NN denotes IRF-4
T1302 2944-2945 -LRB- denotes (
T1303 2945-2965 NN denotes ICSAT/Pip/MUM1/LSIRF
T1304 2965-2966 -RRB- denotes )
T1305 2967-2969 VB denotes is
T1306 2970-2973 CD denotes one
T1307 2974-2980 NN denotes member
T1308 2981-2985 IN denotes with
T1309 2986-2990 RB denotes very
T1310 2991-3001 JJ denotes restricted
T1311 3002-3012 NN denotes expression
T1312 3013-3020 NN denotes pattern
T1313 3020-3021 -COLON- denotes :
T1314 3022-3035 RB denotes Predominately
T1315 3036-3038 NN denotes B-
T1316 3039-3042 CC denotes and
T1317 3043-3052 VB denotes activated
T1318 3053-3066 NN denotes T-lymphocytes
T1319 3067-3070 VB denotes are
T1320 3071-3076 NN denotes IRF-4
T1321 3077-3085 JJ denotes positive
T1322 3086-3087 -LRB- denotes (
T1323 3087-3091 CD denotes 7–11
T1324 3091-3092 -RRB- denotes )
T1325 3094-3096 IN denotes In
T1326 3097-3105 NN denotes contrast
T1327 3106-3108 TO denotes to
T1328 3109-3114 JJ denotes other
T1329 3115-3119 NN denotes IRFs
T1330 3119-3120 -COMMA- denotes ,
T1331 3121-3131 NN denotes expression
T1332 3132-3134 IN denotes of
T1333 3135-3140 NN denotes IRF-4
T1334 3141-3144 MD denotes can
T1335 3144-3147 RB denotes not
T1336 3148-3150 VB denotes be
T1337 3151-3158 VB denotes induced
T1338 3159-3161 IN denotes by
T1339 3162-3166 NN denotes IFNs
T1340 3166-3167 -COMMA- denotes ,
T1341 3168-3171 CC denotes but
T1342 3172-3174 IN denotes by
T1343 3175-3182 NN denotes antigen
T1344 3183-3194 NN denotes stimulation
T1345 3194-3195 -COMMA- denotes ,
T1346 3196-3208 NN denotes crosslinking
T1347 3209-3211 IN denotes of
T1348 3212-3214 NN denotes T-
T1349 3215-3217 CC denotes or
T1350 3218-3224 NN denotes B-cell
T1351 3225-3234 NN denotes receptors
T1352 3235-3237 CC denotes or
T1353 3238-3263 NN denotes phorbol-myristate-acetate
T1354 3264-3265 -LRB- denotes (
T1355 3265-3270 CD denotes 10,11
T1356 3270-3271 -RRB- denotes )
T1357 3273-3283 JJ denotes Consistent
T1358 3284-3288 IN denotes with
T1359 3289-3292 DT denotes the
T1360 3293-3304 NN denotes restriction
T1361 3305-3307 IN denotes of
T1362 3308-3318 NN denotes expression
T1363 3319-3321 TO denotes to
T1364 3322-3337 JJ denotes immunocompetent
T1365 3338-3343 NN denotes cells
T1366 3343-3344 -COMMA- denotes ,
T1367 3345-3349 NN denotes mice
T1368 3350-3354 IN denotes with
T1369 3355-3363 NN denotes deletion
T1370 3364-3366 IN denotes of
T1371 3367-3372 NN denotes IRF-4
T1372 3373-3379 VB denotes failed
T1373 3380-3382 TO denotes to
T1374 3383-3390 VB denotes develop
T1375 3391-3397 JJ denotes mature
T1376 3398-3401 CC denotes and
T1377 3402-3414 RB denotes functionally
T1378 3415-3421 JJ denotes active
T1379 3422-3424 NN denotes B-
T1380 3425-3428 CC denotes and
T1381 3429-3442 NN denotes T-lymphocytes
T1382 3443-3444 -LRB- denotes (
T1383 3444-3446 CD denotes 12
T1384 3446-3447 -RRB- denotes )
T1385 3447-3448 -COMMA- denotes ,
T1386 3449-3452 CC denotes and
T1387 3453-3456 DT denotes the
T1388 3457-3465 JJ denotes impaired
T1389 3466-3476 NN denotes expression
T1390 3477-3479 IN denotes of
T1391 3480-3485 NN denotes IRF-4
T1392 3486-3488 IN denotes in
T1393 3489-3492 NN denotes CML
T1394 3493-3496 VB denotes was
T1395 3497-3510 RB denotes predominately
T1396 3511-3516 VB denotes found
T1397 3517-3519 IN denotes in
T1398 3520-3527 NN denotes T-cells
T1399 3528-3529 -LRB- denotes (
T1400 3529-3530 CD denotes 3
T1401 3530-3531 -RRB- denotes )
T1402 3533-3538 DT denotes These
T1403 3539-3543 NN denotes data
T1404 3544-3551 VB denotes suggest
T1405 3552-3553 DT denotes a
T1406 3554-3561 JJ denotes crucial
T1407 3562-3566 NN denotes role
T1408 3567-3570 IN denotes for
T1409 3571-3576 NN denotes IRF-4
T1410 3577-3579 IN denotes in
T1411 3580-3583 DT denotes the
T1412 3584-3592 NN denotes function
T1413 3593-3595 IN denotes of
T1414 3596-3602 JJ denotes immune
T1415 3603-3608 NN denotes cells
T1416 3610-3621 NN denotes Methylation
T1417 3622-3624 IN denotes of
T1418 3625-3637 NN denotes dinucleotide
T1419 3638-3656 NN denotes cytosine-guanosine
T1420 3657-3663 NN denotes motifs
T1421 3664-3665 -LRB- denotes (
T1422 3665-3668 NN denotes CpG
T1423 3668-3669 -RRB- denotes )
T1424 3669-3670 -COMMA- denotes ,
T1425 3671-3681 RB denotes especially
T1426 3682-3684 IN denotes in
T1427 3685-3688 NN denotes CpG
T1428 3689-3696 NN denotes islands
T1429 3697-3704 VB denotes located
T1430 3705-3707 IN denotes in
T1431 3708-3716 NN denotes promoter
T1432 3717-3724 NN denotes regions
T1433 3724-3725 -COMMA- denotes ,
T1434 3726-3728 VB denotes is
T1435 3729-3732 CD denotes one
T1436 3733-3735 IN denotes of
T1437 3736-3739 DT denotes the
T1438 3740-3750 NN denotes mechanisms
T1439 3751-3753 IN denotes of
T1440 3754-3758 NN denotes gene
T1441 3759-3769 NN denotes regulation
T1442 3770-3772 IN denotes in
T1443 3773-3780 NN denotes mammals
T1444 3781-3784 CC denotes and
T1445 3785-3786 DT denotes a
T1446 3787-3793 JJ denotes common
T1447 3794-3799 NN denotes event
T1448 3800-3802 IN denotes of
T1449 3803-3807 NN denotes gene
T1450 3808-3817 NN denotes silencing
T1451 3818-3820 IN denotes in
T1452 3821-3826 JJ denotes human
T1453 3827-3837 NN denotes neoplasias
T1454 3838-3839 -LRB- denotes (
T1455 3839-3844 CD denotes 13,14
T1456 3844-3845 -RRB- denotes )
T1457 3847-3849 IN denotes As
T1458 3850-3857 VB denotes opposed
T1459 3858-3860 TO denotes to
T1460 3861-3867 JJ denotes normal
T1461 3868-3873 NN denotes cells
T1462 3873-3874 -COMMA- denotes ,
T1463 3875-3891 NN denotes hypermethylation
T1464 3892-3894 IN denotes of
T1465 3895-3898 NN denotes CpG
T1466 3899-3906 NN denotes islands
T1467 3907-3909 VB denotes is
T1468 3910-3911 DT denotes a
T1469 3912-3922 RB denotes frequently
T1470 3923-3931 VB denotes observed
T1471 3932-3942 NN denotes phenomenon
T1472 3943-3945 IN denotes in
T1473 3946-3951 DT denotes every
T1474 3952-3958 NN denotes cancer
T1475 3959-3963 NN denotes type
T1476 3965-3967 FW denotes De
T1477 3968-3972 FW denotes novo
T1478 3973-3976 NN denotes DNA
T1479 3977-3988 NN denotes methylation
T1480 3989-3991 IN denotes of
T1481 3992-3997 NN denotes genes
T1482 3998-4002 JJ denotes such
T1483 4003-4005 IN denotes as
T1484 4006-4010 NN denotes cell
T1485 4011-4016 NN denotes cycle
T1486 4016-4017 -COMMA- denotes ,
T1487 4018-4021 NN denotes DNA
T1488 4022-4028 NN denotes repair
T1489 4028-4029 -COMMA- denotes ,
T1490 4030-4039 NN denotes apoptosis
T1491 4040-4043 CC denotes and
T1492 4044-4049 NN denotes tumor
T1493 4050-4060 NN denotes suppressor
T1494 4061-4066 NN denotes genes
T1495 4067-4069 VB denotes is
T1496 4070-4079 RB denotes therefore
T1497 4080-4087 VB denotes thought
T1498 4088-4090 TO denotes to
T1499 4091-4093 VB denotes be
T1500 4094-4102 VB denotes involved
T1501 4103-4105 IN denotes in
T1502 4106-4119 NN denotes tumorigenesis
T1503 4120-4121 -LRB- denotes (
T1504 4121-4126 CD denotes 15–17
T1505 4126-4127 -RRB- denotes )
T1506 4129-4137 NN denotes Examples
T1507 4138-4141 IN denotes for
T1508 4142-4146 JJ denotes such
T1509 4147-4156 JJ denotes aberrated
T1510 4157-4162 NN denotes genes
T1511 4163-4166 VB denotes are
T1512 4167-4171 NNP denotes MGMT
T1513 4171-4172 -COMMA- denotes ,
T1514 4173-4177 NNP denotes DAPK
T1515 4177-4178 -COMMA- denotes ,
T1516 4179-4185 NN denotes p14ARF
T1517 4185-4186 -COMMA- denotes ,
T1518 4187-4195 NN denotes p15INK4b
T1519 4195-4196 -COMMA- denotes ,
T1520 4197-4205 NN denotes p16INK4a
T1521 4205-4206 -COMMA- denotes ,
T1522 4207-4212 NN denotes BRCA1
T1523 4212-4213 -COMMA- denotes ,
T1524 4214-4219 NN denotes CDH13
T1525 4220-4223 CC denotes and
T1526 4224-4230 NN denotes APAF-1
T1527 4231-4232 -LRB- denotes (
T1528 4232-4237 CD denotes 17–19
T1529 4237-4238 -RRB- denotes )
T1530 4240-4242 IN denotes In
T1531 4243-4246 NN denotes CML
T1532 4246-4247 -COMMA- denotes ,
T1533 4248-4259 NN denotes methylation
T1534 4260-4262 VB denotes is
T1535 4263-4268 VB denotes known
T1536 4269-4271 TO denotes to
T1537 4272-4280 VB denotes regulate
T1538 4281-4291 NN denotes expression
T1539 4292-4294 IN denotes of
T1540 4295-4298 DT denotes the
T1541 4299-4304 NN denotes c-abl
T1542 4304-4305 -COMMA- denotes ,
T1543 4306-4309 DT denotes the
T1544 4310-4313 NN denotes bcr
T1545 4314-4318 NN denotes gene
T1546 4319-4322 CC denotes and
T1547 4323-4329 NN denotes others
T1548 4330-4331 -LRB- denotes (
T1549 4331-4336 CD denotes 20–23
T1550 4336-4337 -RRB- denotes )
T1551 4337-4338 -COMMA- denotes ,
T1552 4339-4342 CC denotes and
T1553 4343-4346 DT denotes the
T1554 4347-4353 NN denotes extent
T1555 4354-4356 IN denotes of
T1556 4357-4368 NN denotes methylation
T1557 4369-4371 IN denotes in
T1558 4372-4375 DT denotes the
T1559 4376-4381 NN denotes c-abl
T1560 4382-4390 NN denotes promoter
T1561 4391-4394 VB denotes has
T1562 4395-4399 VB denotes been
T1563 4400-4405 VB denotes shown
T1564 4406-4408 TO denotes to
T1565 4409-4411 VB denotes be
T1566 4412-4422 VB denotes associated
T1567 4423-4427 IN denotes with
T1568 4428-4436 VB denotes advanced
T1569 4437-4444 NN denotes disease
T1570 4445-4446 -LRB- denotes (
T1571 4446-4448 CD denotes 24
T1572 4448-4449 -RRB- denotes )
T1573 4451-4467 NN denotes Hypermethylation
T1574 4468-4471 IN denotes due
T1575 4472-4474 TO denotes to
T1576 4475-4489 NN denotes overexpression
T1577 4490-4492 IN denotes of
T1578 4493-4496 NN denotes DNA
T1579 4497-4515 NN denotes methyltransferases
T1580 4516-4517 -LRB- denotes (
T1581 4517-4522 NN denotes DNMTs
T1582 4522-4523 -RRB- denotes )
T1583 4524-4531 VB denotes remains
T1584 4532-4535 CD denotes one
T1585 4536-4544 JJ denotes possible
T1586 4545-4556 NN denotes explanation
T1587 4557-4560 IN denotes for
T1588 4561-4563 FW denotes de
T1589 4564-4568 FW denotes novo
T1590 4569-4580 NN denotes methylation
T1591 4581-4583 IN denotes in
T1592 4584-4597 NN denotes tumorigenesis
T1593 4599-4607 RB denotes Recently
T1594 4607-4608 -COMMA- denotes ,
T1595 4609-4614 NN denotes DNMTs
T1596 4615-4619 VB denotes have
T1597 4620-4624 VB denotes been
T1598 4625-4630 VB denotes shown
T1599 4631-4633 TO denotes to
T1600 4634-4636 VB denotes be
T1601 4637-4649 VB denotes up-regulated
T1602 4650-4652 IN denotes in
T1603 4653-4666 JJ denotes hematopoietic
T1604 4667-4679 NN denotes malignancies
T1605 4680-4681 -LRB- denotes (
T1606 4681-4683 CD denotes 25
T1607 4683-4684 -RRB- denotes )
T1608 4686-4704 JJ denotes Methyl-CpG-binding
T1609 4705-4713 NN denotes proteins
T1610 4714-4715 -LRB- denotes (
T1611 4715-4719 NN denotes MBPs
T1612 4719-4720 -RRB- denotes )
T1613 4721-4724 VB denotes are
T1614 4725-4732 VB denotes thought
T1615 4733-4735 TO denotes to
T1616 4736-4743 VB denotes inhibit
T1617 4744-4747 DT denotes the
T1618 4748-4755 NN denotes binding
T1619 4756-4758 IN denotes of
T1620 4759-4774 JJ denotes transcriptional
T1621 4775-4782 NN denotes factors
T1622 4783-4785 TO denotes to
T1623 4786-4789 DT denotes the
T1624 4790-4798 NN denotes promoter
T1625 4799-4802 CC denotes and
T1626 4803-4806 VB denotes are
T1627 4807-4816 RB denotes therefore
T1628 4817-4826 VB denotes discussed
T1629 4827-4829 IN denotes as
T1630 4830-4833 CD denotes one
T1631 4834-4843 NN denotes mechanism
T1632 4844-4846 IN denotes of
T1633 4847-4860 NN denotes transcription
T1634 4861-4871 NN denotes inhibition
T1635 4872-4874 IN denotes by
T1636 4875-4891 NN denotes hypermethylation
T1637 4892-4893 -LRB- denotes (
T1638 4893-4895 CD denotes 26
T1639 4895-4896 -RRB- denotes )
T1640 4898-4900 IN denotes In
T1641 4901-4905 DT denotes this
T1642 4906-4910 NN denotes work
T1643 4910-4911 -COMMA- denotes ,
T1644 4912-4914 PRP denotes we
T1645 4915-4922 VB denotes studied
T1646 4923-4933 NN denotes mechanisms
T1647 4934-4936 IN denotes of
T1648 4937-4942 NN denotes IRF-4
T1649 4943-4947 NN denotes gene
T1650 4948-4958 NN denotes expression
T1651 4959-4968 NN denotes silencing
T1652 4969-4971 IN denotes in
T1653 4972-4980 JJ denotes leukemic
T1654 4981-4986 NN denotes cells
T1655 4988-4990 PRP denotes We
T1656 4991-4999 VB denotes analyzed
T1657 5000-5003 DT denotes the
T1658 5004-5009 NN denotes IRF-4
T1659 5010-5018 NN denotes promoter
T1660 5019-5025 NN denotes region
T1661 5026-5029 IN denotes for
T1662 5030-5037 JJ denotes genetic
T1663 5038-5049 NN denotes aberrations
T1664 5050-5053 CC denotes and
T1665 5054-5067 JJ denotes methylational
T1666 5068-5074 NN denotes status
T1667 5075-5077 IN denotes in
T1668 5078-5092 JJ denotes IRF-4-positive
T1669 5093-5096 CC denotes and
T1670 5097-5106 JJ denotes -negative
T1671 5107-5120 JJ denotes hematopoietic
T1672 5121-5126 NN denotes cells
T2710 5152-5156 NN denotes Cell
T2711 5157-5162 NN denotes lines
T2712 5163-5168 NN denotes K-562
T2713 5168-5169 -COMMA- denotes ,
T2714 5170-5176 NN denotes Jurkat
T2715 5177-5180 CC denotes and
T2716 5181-5186 NN denotes U-937
T2717 5187-5191 VB denotes were
T2718 5192-5200 VB denotes obtained
T2719 5201-5205 IN denotes from
T2720 5206-5209 DT denotes the
T2721 5210-5214 NN denotes ATCC
T2722 5215-5216 -LRB- denotes (
T2723 5216-5224 JJ denotes American
T2724 5225-5229 NN denotes Type
T2725 5230-5237 NNP denotes Culture
T2726 5238-5248 NNP denotes Collection
T2727 5248-5249 -COMMA- denotes ,
T2728 5250-5259 NNP denotes Rockville
T2729 5259-5260 -COMMA- denotes ,
T2730 5261-5264 NNP denotes USA
T2731 5264-5265 -RRB- denotes )
T2732 5266-5269 CC denotes and
T2733 5270-5274 NN denotes EM-2
T2734 5274-5275 -COMMA- denotes ,
T2735 5276-5283 NN denotes LAMA-84
T2736 5283-5284 -COMMA- denotes ,
T2737 5285-5291 NN denotes CML-T1
T2738 5291-5292 -COMMA- denotes ,
T2739 5293-5299 NN denotes BV-173
T2740 5299-5300 -COMMA- denotes ,
T2741 5301-5305 NN denotes SD-1
T2742 5306-5309 CC denotes and
T2743 5310-5319 NN denotes RPMI-8226
T2744 5320-5324 IN denotes from
T2745 5325-5328 DT denotes the
T2746 5329-5333 NN denotes DSMZ
T2747 5334-5335 -LRB- denotes (
T2748 5335-5343 NNP denotes Deutsche
T2749 5344-5352 NNP denotes Sammlung
T2750 5353-5356 NNP denotes von
T2751 5357-5372 NNP denotes Mikroorganismen
T2752 5373-5376 VB denotes und
T2753 5377-5389 NNP denotes Zellkulturen
T2754 5390-5394 NNP denotes GmbH
T2755 5394-5395 -COMMA- denotes ,
T2756 5396-5408 NNP denotes Braunschweig
T2757 5408-5409 -COMMA- denotes ,
T2758 5410-5417 NNP denotes Germany
T2759 5417-5418 -RRB- denotes )
T2760 5420-5423 DT denotes All
T2761 5424-5428 NN denotes cell
T2762 5429-5434 NN denotes lines
T2763 5434-5435 -COMMA- denotes ,
T2764 5436-5442 IN denotes except
T2765 5443-5449 NN denotes BV-173
T2766 5449-5450 -COMMA- denotes ,
T2767 5451-5455 NN denotes SD-1
T2768 5456-5459 CC denotes and
T2769 5460-5469 NN denotes RPMI-8226
T2770 5469-5470 -COMMA- denotes ,
T2771 5471-5475 VB denotes were
T2772 5476-5490 JJ denotes IRF-4-negative
T2862 5493-5497 NN denotes Cell
T2863 5498-5505 NN denotes culture
T2864 5506-5509 CC denotes and
T2865 5510-5521 NN denotes stimulation
T2866 5522-5525 DT denotes All
T2867 5526-5530 NN denotes cell
T2868 5531-5536 NN denotes lines
T2869 5537-5541 VB denotes were
T2870 5542-5552 VB denotes maintained
T2871 5553-5555 IN denotes at
T2872 5556-5557 CD denotes 5
T2873 5557-5558 NN denotes %
T2874 5559-5562 NN denotes CO2
T2875 5563-5565 IN denotes in
T2876 5566-5570 NN denotes RPMI
T2877 5571-5575 CD denotes 1640
T2878 5576-5582 NN denotes medium
T2879 5583-5587 IN denotes with
T2880 5588-5589 CD denotes 1
T2881 5589-5590 NN denotes %
T2882 5591-5600 NN denotes glutamine
T2883 5601-5602 -LRB- denotes (
T2884 5602-5611 NNP denotes Gibco/BRL
T2885 5612-5622 NNP denotes Eggenstein
T2886 5622-5623 -COMMA- denotes ,
T2887 5624-5631 NNP denotes Germany
T2888 5631-5632 -RRB- denotes )
T2889 5633-5645 VB denotes supplemented
T2890 5646-5650 IN denotes with
T2891 5651-5653 CD denotes 10
T2892 5653-5654 NN denotes %
T2893 5655-5660 JJ denotes fetal
T2894 5661-5665 NN denotes calf
T2895 5666-5671 NN denotes serum
T2896 5672-5673 -LRB- denotes (
T2897 5673-5682 NN denotes Gibco/BRL
T2898 5682-5683 -RRB- denotes )
T2899 5683-5684 -COMMA- denotes ,
T2900 5685-5686 CD denotes 1
T2901 5686-5687 NN denotes %
T2902 5688-5711 NN denotes penicillin/streptomycin
T2903 5712-5713 -LRB- denotes (
T2904 5713-5721 NNP denotes Biochrom
T2905 5721-5722 -COMMA- denotes ,
T2906 5723-5729 NNP denotes Berlin
T2907 5729-5730 -COMMA- denotes ,
T2908 5731-5738 NNP denotes Germany
T2909 5738-5739 -RRB- denotes )
T2910 5741-5745 WRB denotes When
T2911 5746-5755 VB denotes indicated
T2912 5755-5756 -COMMA- denotes ,
T2913 5757-5762 NN denotes cells
T2914 5763-5767 VB denotes were
T2915 5768-5775 VB denotes treated
T2916 5776-5780 IN denotes with
T2917 5781-5802 NN denotes 5-aza-2-deoxycytidine
T2918 5803-5804 -LRB- denotes (
T2919 5804-5809 NN denotes AzadC
T2920 5809-5810 -RRB- denotes )
T2921 5811-5813 CC denotes or
T2922 5814-5827 NN denotes 5-azacytidine
T2923 5828-5829 -LRB- denotes (
T2924 5829-5833 NN denotes AzaC
T2925 5833-5834 -RRB- denotes )
T2926 5835-5836 -LRB- denotes (
T2927 5836-5841 NNP denotes Sigma
T2928 5841-5842 -COMMA- denotes ,
T2929 5843-5854 NNP denotes Taufkirchen
T2930 5854-5855 -COMMA- denotes ,
T2931 5856-5863 NNP denotes Germany
T2932 5863-5864 -RRB- denotes )
T2933 5865-5868 IN denotes for
T2934 5869-5878 JJ denotes different
T2935 5879-5883 NN denotes time
T2936 5884-5891 NN denotes periods
T2937 5893-5898 VB denotes Owing
T2938 5899-5901 TO denotes to
T2939 5902-5907 PRP-DOLLAR- denotes their
T2940 5908-5916 JJ denotes chemical
T2941 5917-5928 NN denotes instability
T2942 5929-5934 JJ denotes fresh
T2943 5935-5945 NN denotes substances
T2944 5946-5950 VB denotes were
T2945 5951-5959 JJ denotes re-added
T2946 5960-5965 DT denotes every
T2947 5966-5968 CD denotes 24
T2948 5969-5970 NN denotes h
T3076 6062-6073 NN denotes aberrations
T3077 6074-6078 JJ denotes such
T3078 6079-6081 IN denotes as
T3079 6082-6102 NN denotes insertions/deletions
T3080 6103-6105 CC denotes or
T3081 6106-6114 NN denotes mutation
T3082 6114-6115 -COMMA- denotes ,
T3083 6116-6118 PRP denotes we
T3084 6119-6132 VB denotes PCR-amplified
T3085 6133-6136 CD denotes two
T3086 6137-6146 NN denotes fragments
T3087 6147-6151 IN denotes from
T3088 6152-6159 JJ denotes genomic
T3089 6160-6163 NN denotes DNA
T3090 6163-6164 -COMMA- denotes ,
T3091 6165-6170 WDT denotes which
T3092 6171-6174 VB denotes was
T3093 6175-6184 VB denotes extracted
T3094 6185-6189 IN denotes from
T3095 6190-6198 VB denotes depicted
T3096 6199-6203 NN denotes cell
T3097 6204-6209 NN denotes lines
T3098 6210-6214 IN denotes with
T3099 6215-6216 DT denotes a
T3100 6217-6227 JJ denotes commercial
T3101 6228-6231 NN denotes kit
T3102 6232-6233 -LRB- denotes (
T3103 6233-6239 NN denotes Qiagen
T3104 6239-6240 -COMMA- denotes ,
T3105 6241-6246 NNP denotes Hilde
T3106 6246-6247 -COMMA- denotes ,
T3107 6248-6255 NNP denotes Germany
T3108 6255-6256 -RRB- denotes )
T3109 6257-6259 IN denotes as
T3110 6260-6271 VB denotes recommended
T3111 6273-6276 DT denotes The
T3112 6277-6284 NN denotes primers
T3113 6285-6289 VB denotes were
T3114 6290-6299 JJ denotes 1-forward
T3115 6299-6300 -COLON- denotes :
T3116 6301-6329 JJ denotes 5′-TTGAGATGGAGTCTTGCTCTGT-3′
T3117 6329-6330 -COMMA- denotes ,
T3118 6331-6340 JJ denotes 1-reverse
T3119 6340-6341 -COLON- denotes :
T3120 6342-6371 NN denotes 5′-CCAGGACCTCAGGAGGCCAGTCA-3′
T3121 6371-6372 -COLON- denotes ;
T3122 6373-6382 CD denotes 2-forward
T3123 6382-6383 -COLON- denotes :
T3124 6384-6415 JJ denotes 5′-AGCGGTGAAACTGAGAGTGCGAGGT-3′
T3125 6415-6416 -COMMA- denotes ,
T3126 6417-6426 JJ denotes 2-reverse
T3127 6426-6427 -COLON- denotes :
T3128 6428-6454 NN denotes 5′-GCCACATCGCTGCAGTTTAG-3′
T3129 6456-6459 DT denotes The
T3130 6460-6468 NN denotes products
T3131 6469-6473 VB denotes were
T3132 6474-6480 VB denotes cloned
T3133 6481-6485 IN denotes with
T3134 6486-6489 DT denotes the
T3135 6490-6495 NN denotes ‘TOPO
T3136 6496-6498 NN denotes TA
T3137 6499-6506 NN denotes cloning
T3138 6507-6511 NN denotes kit’
T3139 6512-6513 -LRB- denotes (
T3140 6513-6523 NN denotes Invitrogen
T3141 6523-6524 -COMMA- denotes ,
T3142 6525-6534 NN denotes Groningen
T3143 6534-6535 -COMMA- denotes ,
T3144 6536-6539 DT denotes The
T3145 6540-6551 NNP denotes Netherlands
T3146 6551-6552 -RRB- denotes )
T3147 6554-6559 IN denotes After
T3148 6560-6569 JJ denotes bacterial
T3149 6570-6583 NN denotes amplification
T3150 6584-6586 IN denotes of
T3151 6587-6590 DT denotes the
T3152 6591-6597 VB denotes cloned
T3153 6598-6601 NN denotes PCR
T3154 6602-6611 NN denotes fragments
T3155 6612-6614 IN denotes by
T3156 6615-6623 JJ denotes standard
T3157 6624-6634 NN denotes procedures
T3158 6634-6635 -COMMA- denotes ,
T3159 6636-6638 IN denotes at
T3160 6639-6644 JJ denotes least
T3161 6645-6650 CD denotes three
T3162 6651-6657 NN denotes clones
T3163 6658-6662 IN denotes from
T3164 6663-6667 DT denotes each
T3165 6668-6674 NN denotes sample
T3166 6675-6679 VB denotes were
T3167 6680-6689 VB denotes sequenced
T3168 6690-6694 IN denotes with
T3169 6695-6697 DT denotes an
T3170 6698-6707 VB denotes automated
T3171 6708-6717 NN denotes sequencer
T3172 6718-6719 -LRB- denotes (
T3173 6719-6722 NNP denotes ABI
T3174 6723-6728 NNP denotes Prism
T3175 6729-6732 CD denotes 377
T3176 6732-6733 -COMMA- denotes ,
T3177 6734-6741 NNP denotes Applied
T3178 6742-6753 NNP denotes Bio-systems
T3179 6753-6754 -COMMA- denotes ,
T3180 6755-6761 NNP denotes Foster
T3181 6762-6766 NNP denotes City
T3182 6766-6767 -COMMA- denotes ,
T3183 6768-6771 NNP denotes USA
T3184 6771-6772 -RRB- denotes )
T3185 6773-6775 IN denotes as
T3186 6776-6787 VB denotes recommended
T3187 6788-6790 IN denotes by
T3188 6791-6794 DT denotes the
T3189 6795-6807 NN denotes manufacturer
T3450 6810-6820 NN denotes Expression
T3451 6821-6829 NN denotes analysis
T3452 6830-6832 TO denotes To
T3453 6833-6840 VB denotes analyze
T3454 6841-6844 DT denotes the
T3455 6845-6850 NN denotes IRF-4
T3456 6851-6866 JJ denotes transcriptional
T3457 6867-6872 NN denotes level
T3458 6872-6873 -COMMA- denotes ,
T3459 6874-6877 NN denotes RNA
T3460 6878-6881 VB denotes was
T3461 6882-6891 VB denotes extracted
T3462 6892-6896 IN denotes from
T3463 6897-6902 NN denotes cells
T3464 6903-6908 VB denotes using
T3465 6909-6912 DT denotes the
T3466 6913-6923 JJ denotes commercial
T3467 6924-6934 NN denotes RNAzol-kit
T3468 6935-6936 -LRB- denotes (
T3469 6936-6942 NNP denotes Paesel
T3470 6942-6943 -COMMA- denotes ,
T3471 6944-6953 NNP denotes Frankfurt
T3472 6953-6954 -COMMA- denotes ,
T3473 6955-6962 NNP denotes Germany
T3474 6962-6963 -RRB- denotes )
T3475 6965-6967 DT denotes An
T3476 6968-6975 NN denotes aliquot
T3477 6976-6978 IN denotes of
T3478 6979-6980 CD denotes 1
T3479 6981-6983 NN denotes μg
T3480 6984-6989 JJ denotes total
T3481 6990-6993 NN denotes RNA
T3482 6994-6997 VB denotes was
T3483 6998-7002 VB denotes used
T3484 7003-7006 IN denotes for
T3485 7007-7011 NN denotes cDNA
T3486 7012-7021 NN denotes synthesis
T3487 7022-7024 IN denotes as
T3488 7025-7034 VB denotes described
T3489 7035-7045 RB denotes previously
T3490 7046-7047 -LRB- denotes (
T3491 7047-7049 CD denotes 27
T3492 7049-7050 -RRB- denotes )
T3493 7052-7055 NN denotes RNA
T3494 7056-7066 NN denotes expression
T3495 7067-7075 NN denotes analysis
T3496 7076-7079 IN denotes for
T3497 7080-7085 NN denotes IRF-4
T3498 7086-7089 CC denotes and
T3499 7090-7093 DT denotes the
T3500 7094-7103 NN denotes reference
T3501 7104-7108 NN denotes gene
T3502 7109-7116 NN denotes β-actin
T3503 7117-7120 VB denotes was
T3504 7121-7128 VB denotes carried
T3505 7129-7132 RP denotes out
T3506 7133-7135 IN denotes by
T3507 7136-7153 JJ denotes semi-quantitative
T3508 7154-7157 NN denotes PCR
T3509 7158-7160 IN denotes as
T3510 7161-7170 VB denotes described
T3511 7171-7181 RB denotes previously
T3512 7182-7183 -LRB- denotes (
T3513 7183-7187 CD denotes 3,27
T3514 7187-7188 -RRB- denotes )
T3515 7190-7193 NN denotes PCR
T3516 7194-7202 NN denotes products
T3517 7203-7207 VB denotes were
T3518 7208-7216 VB denotes verified
T3519 7217-7219 IN denotes by
T3520 7220-7229 VB denotes automated
T3521 7230-7240 NN denotes sequencing
T3522 7242-7245 NN denotes PCR
T3523 7246-7253 NN denotes primers
T3524 7254-7257 CC denotes and
T3525 7258-7268 NN denotes conditions
T3526 7269-7272 IN denotes for
T3527 7273-7283 NN denotes expression
T3528 7284-7292 NN denotes analysis
T3529 7293-7295 IN denotes of
T3530 7296-7300 NN denotes DNMT
T3531 7301-7303 CC denotes or
T3532 7304-7307 NN denotes MBP
T3533 7308-7309 -LRB- denotes (
T3534 7309-7314 NN denotes DNMT1
T3535 7315-7321 NN denotes DNMT3A
T3536 7321-7322 -COMMA- denotes ,
T3537 7323-7329 NN denotes DNMT3B
T3538 7329-7330 -COMMA- denotes ,
T3539 7331-7335 NN denotes MeCP
T3540 7335-7336 -COMMA- denotes ,
T3541 7337-7341 NN denotes MBD1
T3542 7341-7342 -COMMA- denotes ,
T3543 7343-7347 NN denotes MBD2
T3544 7348-7351 CC denotes and
T3545 7352-7356 NN denotes MBD4
T3546 7356-7357 -RRB- denotes )
T3547 7358-7362 VB denotes were
T3548 7363-7372 VB denotes published
T3549 7373-7382 RB denotes elsewhere
T3550 7383-7384 -LRB- denotes (
T3551 7384-7386 CD denotes 28
T3552 7386-7387 -RRB- denotes )
T3553 7389-7392 IN denotes For
T3554 7393-7401 NN denotes analysis
T3555 7402-7404 IN denotes of
T3556 7405-7410 NN denotes IRF-4
T3557 7411-7418 NN denotes protein
T3558 7419-7429 NN denotes expression
T3559 7429-7430 -COMMA- denotes ,
T3560 7431-7432 DT denotes a
T3561 7433-7441 JJ denotes standard
T3562 7442-7456 NN denotes immunoblotting
T3563 7457-7462 NN denotes assay
T3564 7463-7466 VB denotes was
T3565 7467-7476 VB denotes performed
T3566 7477-7479 IN denotes as
T3567 7480-7489 VB denotes described
T3568 7490-7500 RB denotes previously
T3569 7501-7502 -LRB- denotes (
T3570 7502-7504 CD denotes 29
T3571 7504-7505 -RRB- denotes )
T3572 7507-7514 RB denotes Briefly
T3573 7514-7515 -COMMA- denotes ,
T3574 7516-7523 NN denotes protein
T3575 7524-7531 NN denotes lysates
T3576 7532-7536 VB denotes were
T3577 7537-7546 VB denotes generated
T3578 7547-7549 IN denotes by
T3579 7550-7560 VB denotes incubating
T3580 7561-7562 CD denotes 1
T3581 7563-7564 NN denotes ×
T3582 7565-7568 CD denotes 106
T3583 7569-7574 NN denotes cells
T3584 7575-7577 IN denotes in
T3585 7578-7581 CD denotes 100
T3586 7582-7584 NN denotes µl
T3587 7585-7589 NN denotes RIPA
T3588 7590-7596 NN denotes buffer
T3589 7597-7598 -LRB- denotes (
T3590 7598-7599 CD denotes 1
T3591 7599-7600 NN denotes %
T3592 7601-7606 NN denotes NP-40
T3593 7606-7607 -COMMA- denotes ,
T3594 7608-7611 CD denotes 0.5
T3595 7611-7612 NN denotes %
T3596 7613-7632 NN denotes sodiumdesoxycholate
T3597 7632-7633 -COMMA- denotes ,
T3598 7634-7637 CD denotes 0.1
T3599 7637-7638 NN denotes %
T3600 7639-7642 NN denotes SDS
T3601 7642-7643 -COMMA- denotes ,
T3602 7644-7647 CD denotes 100
T3603 7648-7653 NN denotes µg/ml
T3604 7654-7674 NN denotes phenylmethylsulfonyl
T3605 7675-7683 NN denotes fluoride
T3606 7683-7684 -COMMA- denotes ,
T3607 7685-7687 CD denotes 10
T3608 7688-7693 NN denotes µl/ml
T3609 7694-7717 NN denotes protease-inhibitory-mix
T3610 7717-7718 -COMMA- denotes ,
T3611 7719-7720 CD denotes 1
T3612 7721-7728 NN denotes µmol/ml
T3613 7729-7748 NN denotes sodiumorthovanadate
T3614 7749-7751 IN denotes in
T3615 7752-7770 JJ denotes phosphate-buffered
T3616 7771-7777 NN denotes saline
T3617 7777-7778 -RRB- denotes )
T3618 7779-7782 IN denotes for
T3619 7783-7785 CD denotes 30
T3620 7786-7789 NN denotes min
T3621 7790-7792 IN denotes on
T3622 7793-7796 NN denotes ice
T3623 7798-7803 IN denotes After
T3624 7804-7818 NN denotes centrifugation
T3625 7818-7819 -COMMA- denotes ,
T3626 7820-7827 NN denotes protein
T3627 7828-7841 NN denotes concentration
T3628 7842-7844 IN denotes of
T3629 7845-7848 DT denotes the
T3630 7849-7860 NN denotes supernatant
T3631 7861-7864 VB denotes was
T3632 7865-7875 VB denotes determined
T3633 7876-7878 IN denotes by
T3634 7879-7889 NN denotes BCA-method
T3635 7890-7891 -LRB- denotes (
T3636 7891-7897 NNP denotes Pierce
T3637 7897-7898 -COMMA- denotes ,
T3638 7899-7907 NNP denotes Rockford
T3639 7907-7908 -COMMA- denotes ,
T3640 7909-7911 NN denotes IL
T3641 7911-7912 -RRB- denotes )
T3642 7913-7915 IN denotes as
T3643 7916-7927 VB denotes recommended
T3644 7929-7936 NN denotes Protein
T3645 7937-7944 NN denotes lysates
T3646 7945-7946 -LRB- denotes (
T3647 7946-7952 CD denotes 70–100
T3648 7953-7955 NN denotes µg
T3649 7955-7956 -RRB- denotes )
T3650 7957-7961 VB denotes were
T3651 7962-7977 VB denotes electrophoresed
T3652 7978-7980 IN denotes on
T3653 7981-7995 NN denotes polyacrylamide
T3654 7996-8000 NN denotes gels
T3655 8001-8004 CC denotes and
T3656 8005-8016 VB denotes transferred
T3657 8017-8019 TO denotes to
T3658 8020-8021 DT denotes a
T3659 8022-8035 NN denotes PVDF-membrane
T3660 8036-8037 -LRB- denotes (
T3661 8037-8046 NNP denotes Immobilon
T3662 8047-8048 NNP denotes P
T3663 8048-8049 -COMMA- denotes ,
T3664 8050-8054 CD denotes 0.45
T3665 8055-8057 NN denotes µm
T3666 8057-8058 -COLON- denotes ;
T3667 8059-8068 NNP denotes Millipore
T3668 8068-8069 -COMMA- denotes ,
T3669 8070-8078 NNP denotes Eschborn
T3670 8078-8079 -COMMA- denotes ,
T3671 8080-8087 NNP denotes Germany
T3672 8087-8088 -RRB- denotes )
T3673 8090-8099 NN denotes Membranes
T3674 8100-8104 VB denotes were
T3675 8105-8112 VB denotes blocked
T3676 8113-8117 IN denotes with
T3677 8118-8121 CD denotes 2.5
T3678 8121-8122 NN denotes %
T3679 8123-8131 VB denotes blocking
T3680 8132-8139 NN denotes reagent
T3681 8140-8141 -LRB- denotes (
T3682 8141-8151 NNP denotes Boehringer
T3683 8152-8160 NNP denotes Mannheim
T3684 8160-8161 -COMMA- denotes ,
T3685 8162-8169 NNP denotes Germany
T3686 8169-8170 -RRB- denotes )
T3687 8171-8173 IN denotes in
T3688 8174-8178 NN denotes TBST
T3689 8179-8185 NN denotes buffer
T3690 8186-8187 -LRB- denotes (
T3691 8187-8191 CD denotes 4.44
T3692 8192-8195 NN denotes g/l
T3693 8196-8204 NN denotes Tris–HCL
T3694 8204-8205 -COMMA- denotes ,
T3695 8206-8210 CD denotes 2.65
T3696 8211-8214 NN denotes g/l
T3697 8215-8221 NN denotes TrisOH
T3698 8221-8222 -COMMA- denotes ,
T3699 8223-8227 CD denotes 8.07
T3700 8228-8231 NN denotes g/l
T3701 8232-8236 NN denotes NaCl
T3702 8236-8237 -COMMA- denotes ,
T3703 8238-8241 CD denotes 0.2
T3704 8242-8245 NN denotes g/l
T3705 8246-8249 NN denotes KCl
T3706 8250-8253 CC denotes and
T3707 8254-8257 CD denotes 500
T3708 8258-8262 VB denotes µl/l
T3709 8263-8271 CD denotes Tween-20
T3710 8272-8274 IN denotes in
T3711 8275-8278 NN denotes H2O
T3712 8278-8279 -RRB- denotes )
T3713 8280-8283 CC denotes and
T3714 8284-8296 RB denotes subsequently
T3715 8297-8306 VB denotes incubated
T3716 8307-8311 IN denotes with
T3717 8312-8319 JJ denotes primary
T3718 8320-8328 NN denotes antibody
T3719 8329-8331 IN denotes as
T3720 8332-8341 VB denotes indicated
T3721 8342-8345 CC denotes and
T3722 8346-8357 JJ denotes horseradish
T3723 8358-8379 JJ denotes peroxidase-conjugated
T3724 8380-8389 JJ denotes secondary
T3725 8390-8398 NN denotes antibody
T3726 8398-8399 -COMMA- denotes ,
T3727 8400-8410 JJ denotes anti-mouse
T3728 8411-8413 CC denotes or
T3729 8414-8423 JJ denotes anti-goat
T3730 8424-8427 NN denotes IgG
T3731 8428-8429 -LRB- denotes (
T3732 8429-8433 NNP denotes DAKO
T3733 8433-8434 -COMMA- denotes ,
T3734 8435-8442 NNP denotes Hamburg
T3735 8442-8443 -COMMA- denotes ,
T3736 8444-8451 NNP denotes Germany
T3737 8451-8452 -RRB- denotes )
T3738 8452-8453 -COMMA- denotes ,
T3739 8454-8466 RB denotes respectively
T3740 8468-8471 DT denotes The
T3741 8472-8481 NN denotes membranes
T3742 8482-8486 VB denotes were
T3743 8487-8491 RB denotes then
T3744 8492-8501 VB denotes developed
T3745 8502-8506 IN denotes with
T3746 8507-8509 DT denotes an
T3747 8510-8513 NN denotes ECL
T3748 8514-8523 NN denotes detection
T3749 8524-8527 NN denotes kit
T3750 8528-8529 -LRB- denotes (
T3751 8529-8537 NNP denotes Amersham
T3752 8538-8547 NNP denotes Pharmacia
T3753 8548-8555 NNP denotes Biotech
T3754 8555-8556 -COMMA- denotes ,
T3755 8557-8565 NNP denotes Freiburg
T3756 8565-8566 -COMMA- denotes ,
T3757 8567-8574 NNP denotes Germany
T3758 8574-8575 -RRB- denotes )
T3759 8577-8580 DT denotes The
T3760 8581-8588 JJ denotes primary
T3761 8589-8599 NN denotes antibodies
T3762 8600-8604 VB denotes were
T3763 8605-8609 NN denotes goat
T3764 8610-8626 NN denotes anti-IRF-4/ICSAT
T3765 8627-8628 -LRB- denotes (
T3766 8628-8632 NN denotes M-17
T3767 8632-8633 -RRB- denotes )
T3768 8634-8635 -LRB- denotes (
T3769 8635-8640 NNP denotes Santa
T3770 8641-8645 NNP denotes Cruz
T3771 8646-8659 NNP denotes Biotechnology
T3772 8659-8660 -COMMA- denotes ,
T3773 8661-8666 NNP denotes Santa
T3774 8667-8671 NNP denotes Cruz
T3775 8671-8672 -COMMA- denotes ,
T3776 8673-8675 NN denotes CA
T3777 8675-8676 -RRB- denotes )
T3778 8677-8680 CC denotes and
T3779 8681-8686 NN denotes mouse
T3780 8687-8699 JJ denotes anti-β-actin
T3781 8700-8701 -LRB- denotes (
T3782 8701-8706 NN denotes AC-74
T3783 8706-8707 -RRB- denotes )
T3784 8708-8709 -LRB- denotes (
T3785 8709-8714 NN denotes Sigma
T3786 8714-8715 -RRB- denotes )
T4371 8718-8738 JJ denotes Methylation-specific
T4372 8739-8760 NN denotes restriction-PCR-assay
T4373 8761-8764 NN denotes DNA
T4374 8765-8768 VB denotes was
T4375 8769-8778 VB denotes extracted
T4376 8779-8783 IN denotes with
T4377 8784-8785 DT denotes a
T4378 8786-8796 JJ denotes commercial
T4379 8797-8800 NN denotes kit
T4380 8801-8802 -LRB- denotes (
T4381 8802-8808 NN denotes Qiagen
T4382 8808-8809 -RRB- denotes )
T4383 8810-8812 IN denotes as
T4384 8813-8824 VB denotes recommended
T4385 8826-8831 IN denotes Since
T4386 8832-8835 DT denotes the
T4387 8836-8847 NN denotes restriction
T4388 8848-8855 NN denotes ability
T4389 8856-8858 IN denotes of
T4390 8859-8866 JJ denotes several
T4391 8867-8880 NN denotes endonucleases
T4392 8881-8883 VB denotes is
T4393 8884-8893 VB denotes inhibited
T4394 8894-8896 IN denotes by
T4395 8897-8908 NN denotes methylation
T4396 8909-8911 IN denotes of
T4397 8912-8917 PRP-DOLLAR- denotes their
T4398 8918-8924 NN denotes target
T4399 8925-8933 NN denotes sequence
T4400 8933-8934 -COMMA- denotes ,
T4401 8935-8937 PRP denotes we
T4402 8938-8942 VB denotes used
T4403 8943-8964 JJ denotes methylation-sensitive
T4404 8965-8972 NN denotes enzymes
T4405 8973-8978 NN denotes HpaII
T4406 8979-8982 CC denotes and
T4407 8983-9000 NN denotes HaeII-isochizomer
T4408 9001-9009 NN denotes Bsp143II
T4409 9010-9013 CC denotes and
T4410 9014-9022 NN denotes Bsh1236I
T4411 9023-9024 -LRB- denotes (
T4412 9024-9027 NNP denotes MBI
T4413 9028-9037 NNP denotes Fermentas
T4414 9037-9038 -COMMA- denotes ,
T4415 9039-9041 NNP denotes St
T4416 9042-9050 NNP denotes Leon-Rot
T4417 9050-9051 -COMMA- denotes ,
T4418 9052-9059 NNP denotes Germany
T4419 9059-9060 -RRB- denotes )
T4420 9061-9062 -LRB- denotes (
T4421 9062-9067 CD denotes 20,24
T4422 9067-9068 -RRB- denotes )
T4423 9070-9072 IN denotes As
T4424 9073-9080 VB denotes control
T4425 9081-9084 DT denotes the
T4426 9085-9106 JJ denotes methylation-resistant
T4427 9107-9113 NN denotes enzyme
T4428 9114-9118 NN denotes MspI
T4429 9119-9122 CC denotes and
T4430 9123-9125 DT denotes an
T4431 9126-9132 NN denotes enzyme
T4432 9133-9137 IN denotes with
T4433 9138-9140 DT denotes no
T4434 9141-9152 NN denotes recognition
T4435 9153-9157 NN denotes site
T4436 9158-9160 IN denotes in
T4437 9161-9164 DT denotes the
T4438 9165-9171 NN denotes target
T4439 9172-9180 NN denotes promoter
T4440 9180-9181 -COMMA- denotes ,
T4441 9182-9187 NN denotes EcoRI
T4442 9187-9188 -COMMA- denotes ,
T4443 9189-9193 VB denotes were
T4444 9194-9198 VB denotes used
T4445 9200-9203 NN denotes DNA
T4446 9204-9205 -LRB- denotes (
T4447 9205-9208 CD denotes 0.8
T4448 9209-9211 NN denotes µg
T4449 9211-9212 -RRB- denotes )
T4450 9213-9216 VB denotes was
T4451 9217-9225 VB denotes digested
T4452 9226-9228 IN denotes by
T4453 9229-9231 CD denotes 40
T4454 9232-9233 NN denotes U
T4455 9234-9237 DT denotes the
T4456 9238-9248 JJ denotes respective
T4457 9249-9255 NN denotes enzyme
T4458 9256-9259 IN denotes for
T4459 9260-9261 CD denotes 6
T4460 9262-9263 NN denotes h
T4461 9264-9267 CC denotes and
T4462 9267-9268 -COMMA- denotes ,
T4463 9269-9271 TO denotes to
T4464 9272-9278 VB denotes ensure
T4465 9279-9287 JJ denotes complete
T4466 9288-9296 NN denotes cleavage
T4467 9296-9297 -COMMA- denotes ,
T4468 9298-9308 JJ denotes additional
T4469 9309-9311 CD denotes 20
T4470 9312-9313 NN denotes U
T4471 9314-9317 IN denotes for
T4472 9318-9320 CD denotes 16
T4473 9321-9322 NN denotes h
T4474 9324-9334 RB denotes Thereafter
T4475 9335-9338 CD denotes 100
T4476 9339-9341 NN denotes ng
T4477 9342-9344 IN denotes of
T4478 9345-9353 JJ denotes digested
T4479 9354-9357 NN denotes DNA
T4480 9358-9361 VB denotes was
T4481 9362-9366 VB denotes used
T4482 9367-9369 TO denotes to
T4483 9370-9371 DT denotes a
T4484 9372-9375 NN denotes PCR
T4485 9376-9389 NN denotes amplification
T4486 9390-9392 IN denotes of
T4487 9393-9396 CD denotes two
T4488 9397-9406 NN denotes fragments
T4489 9407-9408 -LRB- denotes (
T4490 9408-9410 NN denotes F1
T4491 9411-9414 CC denotes and
T4492 9415-9417 NN denotes F2
T4493 9417-9418 -RRB- denotes )
T4494 9419-9427 VB denotes spanning
T4495 9428-9432 NN denotes part
T4496 9433-9435 IN denotes of
T4497 9436-9439 DT denotes the
T4498 9440-9445 NN denotes IRF-4
T4499 9446-9454 NN denotes promoter
T4500 9455-9456 -LRB- denotes (
T4501 9456-9458 CD denotes 30
T4502 9458-9459 -RRB- denotes )
T4503 9460-9461 -LRB- denotes (
T4504 9461-9468 NN denotes GenBank
T4505 9469-9475 NN denotes U52683
T4506 9475-9476 -COLON- denotes ;
T4507 9477-9480 VB denotes see
T4508 9481-9487 NN denotes Figure
T4509 9488-9490 NN denotes 3A
T4510 9490-9491 -RRB- denotes )
T4511 9493-9496 DT denotes The
T4512 9497-9506 NN denotes sequences
T4513 9507-9509 IN denotes of
T4514 9510-9513 DT denotes the
T4515 9514-9521 NN denotes primers
T4516 9522-9526 VB denotes were
T4517 9527-9537 JJ denotes F1-forward
T4518 9537-9538 -COLON- denotes :
T4519 9539-9567 JJ denotes 5′-TTGAGATGGAGTCTTGCTCTGT-3′
T4520 9567-9568 -COMMA- denotes ,
T4521 9569-9579 JJ denotes F1-reverse
T4522 9579-9580 -COLON- denotes :
T4523 9581-9609 NN denotes ATCACTTCCAGACTTCAGTTCACCT-3′
T4524 9610-9611 -LRB- denotes (
T4525 9611-9614 CD denotes 341
T4526 9615-9617 NN denotes bp
T4527 9617-9618 -RRB- denotes )
T4528 9618-9619 -COLON- denotes ;
T4529 9620-9630 JJ denotes F2-forward
T4530 9630-9631 -COLON- denotes :
T4531 9632-9663 JJ denotes 5′-AAGGTGAACTGAAGTCTGGAAGTGA-3′
T4532 9663-9664 -COMMA- denotes ,
T4533 9665-9675 JJ denotes F2-reverse
T4534 9675-9676 -COLON- denotes :
T4535 9677-9706 NN denotes 5′-CCAGGACCTCAGGAGGCCAGTCA-3′
T4536 9707-9708 -LRB- denotes (
T4537 9708-9711 CD denotes 474
T4538 9712-9714 NN denotes bp
T4539 9714-9715 -RRB- denotes )
T4540 9717-9720 DT denotes The
T4541 9721-9724 NN denotes PCR
T4542 9725-9735 NN denotes conditions
T4543 9736-9740 VB denotes were
T4544 9741-9750 VB denotes described
T4545 9751-9760 RB denotes elsewhere
T4546 9761-9762 -LRB- denotes (
T4547 9762-9763 CD denotes 3
T4548 9763-9764 -RRB- denotes )
T4549 9766-9769 NN denotes PCR
T4550 9770-9773 VB denotes was
T4551 9774-9783 VB denotes performed
T4552 9784-9788 IN denotes with
T4553 9789-9791 DT denotes an
T4554 9792-9801 JJ denotes annealing
T4555 9802-9813 NN denotes temperature
T4556 9814-9816 IN denotes of
T4557 9817-9821 NN denotes 62°C
T4558 9822-9825 CC denotes and
T4559 9826-9828 CD denotes 35
T4560 9829-9835 NN denotes cycles
T4561 9837-9841 WRB denotes When
T4562 9842-9845 NN denotes DNA
T4563 9846-9849 VB denotes was
T4564 9850-9860 VB denotes methylated
T4565 9861-9863 IN denotes at
T4566 9864-9872 JJ denotes specific
T4567 9873-9878 NN denotes sites
T4568 9878-9879 -COMMA- denotes ,
T4569 9880-9883 DT denotes the
T4570 9884-9893 JJ denotes sensitive
T4571 9894-9901 NN denotes enzymes
T4572 9902-9906 VB denotes were
T4573 9907-9910 RB denotes not
T4574 9911-9915 JJ denotes able
T4575 9916-9918 TO denotes to
T4576 9919-9925 VB denotes digest
T4577 9926-9929 DT denotes the
T4578 9930-9933 NN denotes DNA
T4579 9934-9937 CC denotes and
T4580 9938-9951 NN denotes amplification
T4581 9952-9956 VB denotes took
T4582 9957-9962 NN denotes place
T4583 9962-9963 -COLON- denotes ;
T4584 9964-9966 IN denotes in
T4585 9967-9971 NN denotes case
T4586 9972-9974 IN denotes of
T4587 9975-9977 DT denotes no
T4588 9978-9989 NN denotes methylation
T4589 9989-9990 -COMMA- denotes ,
T4590 9991-9994 NN denotes DNA
T4591 9995-9998 VB denotes was
T4592 9999-10007 VB denotes digested
T4593 10008-10011 CC denotes and
T4594 10012-10014 DT denotes no
T4595 10015-10022 NN denotes product
T4596 10023-10026 VB denotes was
T4597 10027-10036 VB denotes generated
T4598 10038-10041 DT denotes The
T4599 10042-10045 NN denotes PCR
T4600 10046-10054 NN denotes products
T4601 10055-10059 VB denotes were
T4602 10060-10075 VB denotes electrophoresed
T4603 10076-10078 IN denotes on
T4604 10079-10080 DT denotes a
T4605 10081-10082 CD denotes 3
T4606 10082-10083 NN denotes %
T4607 10084-10091 NN denotes agarose
T4608 10092-10095 NN denotes gel
T4609 10095-10096 -COMMA- denotes ,
T4610 10097-10101 VB denotes were
T4611 10102-10109 VB denotes stained
T4612 10110-10114 IN denotes with
T4613 10115-10123 NN denotes ethidium
T4614 10124-10131 NN denotes bromide
T4615 10132-10135 CC denotes and
T4616 10136-10148 VB denotes photographed
T4617 10150-10153 NN denotes PCR
T4618 10154-10162 NN denotes products
T4619 10163-10167 VB denotes were
T4620 10168-10176 VB denotes verified
T4621 10177-10179 IN denotes by
T4622 10180-10189 VB denotes automated
T4623 10190-10200 NN denotes sequencing
T4943 10203-10212 NN denotes Bisulfite
T4944 10213-10222 NN denotes treatment
T4945 10223-10226 NN denotes DNA
T4946 10227-10230 VB denotes was
T4947 10231-10240 VB denotes extracted
T4948 10241-10243 IN denotes as
T4949 10244-10253 VB denotes described
T4950 10254-10259 RB denotes above
T4951 10261-10270 NN denotes Bisulfite
T4952 10271-10280 NN denotes treatment
T4953 10281-10283 IN denotes of
T4954 10284-10287 NN denotes DNA
T4955 10287-10288 -COMMA- denotes ,
T4956 10289-10296 VB denotes leading
T4957 10297-10299 TO denotes to
T4958 10300-10310 NN denotes conversion
T4959 10311-10313 IN denotes of
T4960 10314-10326 JJ denotes unmethylated
T4961 10327-10335 NN denotes cytosine
T4962 10336-10338 TO denotes to
T4963 10339-10345 NN denotes uracil
T4964 10346-10354 NN denotes residues
T4965 10355-10358 CC denotes and
T4966 10359-10361 DT denotes no
T4967 10362-10368 NN denotes change
T4968 10369-10371 IN denotes of
T4969 10372-10382 VB denotes methylated
T4970 10383-10391 NN denotes cytosine
T4971 10392-10400 NN denotes residues
T4972 10400-10401 -COMMA- denotes ,
T4973 10402-10405 VB denotes was
T4974 10406-10415 VB denotes performed
T4975 10416-10418 IN denotes as
T4976 10419-10428 VB denotes described
T4977 10429-10431 IN denotes as
T4978 10432-10439 VB denotes follows
T4979 10441-10448 RB denotes Briefly
T4980 10448-10449 -COMMA- denotes ,
T4981 10450-10451 CD denotes 1
T4982 10452-10454 NN denotes µg
T4983 10455-10457 IN denotes of
T4984 10458-10461 NN denotes DNA
T4985 10462-10465 CC denotes and
T4986 10466-10467 CD denotes 2
T4987 10468-10470 NN denotes µg
T4988 10471-10473 IN denotes of
T4989 10474-10478 NN denotes poly
T4990 10478-10479 -LRB- denotes (
T4991 10479-10484 NN denotes dA–dT
T4992 10484-10485 -RRB- denotes )
T4993 10485-10486 -LRB- denotes (
T4994 10486-10490 NN denotes poly
T4995 10490-10491 -LRB- denotes (
T4996 10491-10496 NN denotes dA–dT
T4997 10496-10497 -RRB- denotes )
T4998 10498-10508 NN denotes copolymers
T4999 10509-10510 -LRB- denotes (
T5000 10510-10518 NNP denotes Amersham
T5001 10519-10528 NNP denotes Pharmacia
T5002 10529-10536 NNP denotes Biotech
T5003 10536-10537 -RRB- denotes )
T5004 10538-10542 VB denotes were
T5005 10543-10554 VB denotes denaturated
T5006 10555-10558 IN denotes for
T5007 10559-10561 CD denotes 20
T5008 10562-10565 NN denotes min
T5009 10566-10568 IN denotes at
T5010 10569-10573 NN denotes 42°C
T5011 10574-10576 IN denotes in
T5012 10577-10580 CD denotes 0.3
T5013 10581-10582 NN denotes M
T5014 10583-10587 NN denotes NaOH
T5015 10588-10590 IN denotes in
T5016 10591-10592 DT denotes a
T5017 10593-10599 NN denotes volume
T5018 10600-10602 IN denotes of
T5019 10603-10605 CD denotes 50
T5020 10606-10608 NN denotes µl
T5021 10610-10615 JJ denotes Fresh
T5022 10616-10625 NN denotes solutions
T5023 10626-10628 IN denotes of
T5024 10629-10631 CD denotes 30
T5025 10632-10634 NN denotes µl
T5026 10635-10637 IN denotes of
T5027 10638-10640 CD denotes 10
T5028 10641-10643 NN denotes mM
T5029 10644-10655 NN denotes hydrochinon
T5030 10656-10657 -LRB- denotes (
T5031 10657-10662 NN denotes Sigma
T5032 10662-10663 -RRB- denotes )
T5033 10664-10667 CC denotes and
T5034 10668-10671 CD denotes 530
T5035 10672-10674 NN denotes µl
T5036 10675-10677 IN denotes of
T5037 10678-10679 CD denotes 3
T5038 10680-10681 NN denotes M
T5039 10682-10688 NN denotes sodium
T5040 10689-10698 NN denotes bisulfite
T5041 10699-10700 -LRB- denotes (
T5042 10700-10702 NN denotes pH
T5043 10703-10706 CD denotes 5.0
T5044 10706-10707 -COLON- denotes ;
T5045 10708-10713 NNP denotes Sigma
T5046 10713-10714 -RRB- denotes )
T5047 10715-10719 VB denotes were
T5048 10720-10725 VB denotes added
T5049 10725-10726 -COMMA- denotes ,
T5050 10727-10730 DT denotes the
T5051 10731-10739 NN denotes solution
T5052 10740-10743 VB denotes was
T5053 10744-10750 RB denotes gently
T5054 10751-10756 VB denotes mixed
T5055 10756-10757 -COMMA- denotes ,
T5056 10758-10767 VB denotes overlayed
T5057 10768-10772 IN denotes with
T5058 10773-10780 NN denotes mineral
T5059 10781-10784 NN denotes oil
T5060 10785-10788 CC denotes and
T5061 10789-10798 VB denotes incubated
T5062 10799-10801 IN denotes in
T5063 10802-10805 DT denotes the
T5064 10806-10810 NN denotes dark
T5065 10811-10814 IN denotes for
T5066 10815-10820 CD denotes 12–13
T5067 10821-10822 NN denotes h
T5068 10823-10825 IN denotes at
T5069 10826-10831 NNP denotes 50°C.
T5070 10832-10835 DT denotes The
T5071 10836-10843 JJ denotes aqueous
T5072 10844-10849 NN denotes phase
T5073 10850-10853 VB denotes was
T5074 10854-10863 VB denotes recovered
T5075 10864-10869 VB denotes using
T5076 10870-10873 DT denotes the
T5077 10874-10881 NNP denotes ‘Wizard
T5078 10882-10885 NN denotes DNA
T5079 10886-10894 NN denotes clean-up
T5080 10895-10902 NN denotes system’
T5081 10903-10904 -LRB- denotes (
T5082 10904-10911 NNP denotes Promega
T5083 10911-10912 -COMMA- denotes ,
T5084 10913-10921 NNP denotes Mannheim
T5085 10921-10922 -COMMA- denotes ,
T5086 10923-10930 NNP denotes Germany
T5087 10930-10931 -RRB- denotes )
T5088 10933-10936 DT denotes The
T5089 10937-10945 VB denotes purified
T5090 10946-10949 NN denotes DNA
T5091 10950-10953 VB denotes was
T5092 10954-10966 RB denotes subsequently
T5093 10967-10972 VB denotes mixed
T5094 10973-10977 IN denotes with
T5095 10978-10979 CD denotes 1
T5096 10980-10981 NN denotes M
T5097 10982-10986 NN denotes NaOH
T5098 10987-10989 TO denotes to
T5099 10990-10991 DT denotes a
T5100 10992-10997 JJ denotes final
T5101 10998-11011 NN denotes concentration
T5102 11012-11014 IN denotes of
T5103 11015-11018 CD denotes 0.3
T5104 11019-11020 NN denotes M
T5105 11021-11024 CC denotes and
T5106 11025-11034 VB denotes incubated
T5107 11035-11038 IN denotes for
T5108 11039-11041 CD denotes 20
T5109 11042-11045 NN denotes min
T5110 11046-11048 IN denotes at
T5111 11049-11053 NN denotes 37°C
T5112 11054-11056 TO denotes to
T5113 11057-11063 VB denotes ensure
T5114 11064-11072 JJ denotes complete
T5115 11073-11088 NN denotes desulfonisation
T5116 11090-11093 NN denotes DNA
T5117 11094-11097 VB denotes was
T5118 11098-11105 NN denotes ethanol
T5119 11106-11118 VB denotes precipitated
T5120 11119-11121 IN denotes in
T5121 11122-11125 DT denotes the
T5122 11126-11134 NN denotes presence
T5123 11135-11137 IN denotes of
T5124 11138-11142 CD denotes 1/10
T5125 11143-11146 NN denotes vol
T5126 11147-11149 IN denotes of
T5127 11150-11151 CD denotes 3
T5128 11152-11153 NN denotes M
T5129 11154-11160 NN denotes sodium
T5130 11161-11168 NN denotes acetate
T5131 11168-11169 -COMMA- denotes ,
T5132 11170-11176 VB denotes washed
T5133 11177-11181 IN denotes with
T5134 11182-11184 CD denotes 70
T5135 11184-11185 NN denotes %
T5136 11186-11193 NN denotes ethanol
T5137 11194-11197 CC denotes and
T5138 11198-11209 VB denotes resuspended
T5139 11210-11212 IN denotes in
T5140 11213-11215 CD denotes 50
T5141 11216-11218 NN denotes µl
T5142 11219-11222 NN denotes H2O
T5143 11224-11234 JJ denotes Subsequent
T5144 11235-11238 NN denotes PCR
T5145 11239-11252 NN denotes amplification
T5146 11253-11255 IN denotes of
T5147 11256-11257 CD denotes 4
T5148 11258-11260 NN denotes µl
T5149 11261-11278 JJ denotes bisulfite-treated
T5150 11279-11282 NN denotes DNA
T5151 11283-11286 VB denotes was
T5152 11287-11291 VB denotes used
T5153 11292-11295 IN denotes for
T5154 11296-11303 NN denotes cloning
T5155 11304-11306 IN denotes of
T5156 11307-11310 CD denotes two
T5157 11311-11320 NN denotes fragments
T5158 11321-11323 IN denotes of
T5159 11324-11327 DT denotes the
T5160 11328-11333 NN denotes IRF-4
T5161 11334-11342 NN denotes promoter
T5162 11343-11344 -LRB- denotes (
T5163 11344-11348 NN denotes BS-I
T5164 11349-11352 CC denotes and
T5165 11353-11358 NN denotes BS-II
T5166 11358-11359 -RRB- denotes )
T5167 11360-11364 IN denotes into
T5168 11365-11371 NN denotes pCR2.1
T5169 11372-11378 NN denotes vector
T5170 11379-11383 IN denotes with
T5171 11384-11387 DT denotes the
T5172 11388-11393 NN denotes ‘TOPO
T5173 11394-11396 NN denotes TA
T5174 11397-11404 NN denotes cloning
T5175 11405-11409 NN denotes kit’
T5176 11410-11411 -LRB- denotes (
T5177 11411-11421 NN denotes Invitrogen
T5178 11421-11422 -RRB- denotes )
T5179 11423-11424 -LRB- denotes (
T5180 11424-11427 VB denotes see
T5181 11428-11434 NN denotes Figure
T5182 11435-11437 NN denotes 3A
T5183 11437-11438 -RRB- denotes )
T5184 11440-11443 DT denotes The
T5185 11444-11451 NN denotes primers
T5186 11452-11456 VB denotes used
T5187 11457-11460 IN denotes for
T5188 11461-11464 NN denotes PCR
T5189 11465-11478 NN denotes amplification
T5190 11479-11481 IN denotes of
T5191 11482-11485 DT denotes the
T5192 11486-11490 NN denotes BS-I
T5193 11491-11494 CC denotes and
T5194 11495-11500 NN denotes BS-II
T5195 11501-11510 NN denotes fragments
T5196 11511-11518 VB denotes contain
T5197 11519-11522 DT denotes the
T5198 11523-11531 JJ denotes putative
T5199 11532-11539 JJ denotes altered
T5200 11540-11548 NN denotes sequence
T5201 11549-11551 IN denotes of
T5202 11552-11555 DT denotes the
T5203 11556-11561 NN denotes sense
T5204 11562-11568 NN denotes strand
T5205 11569-11572 JJ denotes due
T5206 11573-11575 TO denotes to
T5207 11576-11585 VB denotes bisulfite
T5208 11586-11595 NN denotes treatment
T5209 11596-11597 -LRB- denotes (
T5210 11597-11606 VB denotes converted
T5211 11607-11615 NN denotes cytosine
T5212 11616-11624 NN denotes residues
T5213 11625-11628 VB denotes are
T5214 11629-11636 VB denotes written
T5215 11637-11639 IN denotes in
T5216 11640-11644 JJ denotes bold
T5217 11645-11652 NN denotes letters
T5218 11652-11653 -RRB- denotes )
T5219 11653-11654 -COLON- denotes :
T5220 11655-11667 JJ denotes BS-I-forward
T5221 11668-11701 NN denotes 5′-TATTTGGATTTTTAGGGAGTTTTTTTT-3′
T5222 11701-11702 -COMMA- denotes ,
T5223 11703-11715 JJ denotes BS-I-reverse
T5224 11716-11748 NN denotes 5′-ACCCAACTCCCTTAAACTATTAAACT-3′
T5225 11749-11750 -LRB- denotes (
T5226 11750-11753 CD denotes 187
T5227 11754-11756 NN denotes bp
T5228 11756-11757 -RRB- denotes )
T5229 11757-11758 -COLON- denotes ;
T5230 11759-11772 JJ denotes BS-II-forward
T5231 11773-11805 NN denotes 5′-AGTTTAATAGTTTAAGGGAGTTGGGT-3′
T5232 11805-11806 -COMMA- denotes ,
T5233 11807-11820 JJ denotes BS-II-reverse
T5234 11821-11853 NN denotes 5′-CTCACCCTAAACTCAAAACTAAAAAC-3′
T5235 11854-11855 -LRB- denotes (
T5236 11855-11858 CD denotes 674
T5237 11859-11861 NN denotes bp
T5238 11861-11862 -RRB- denotes )
T5239 11864-11869 IN denotes After
T5240 11870-11879 JJ denotes bacterial
T5241 11880-11893 NN denotes amplification
T5242 11894-11896 IN denotes of
T5243 11897-11900 DT denotes the
T5244 11901-11907 VB denotes cloned
T5245 11908-11911 NN denotes PCR
T5246 11912-11921 NN denotes fragments
T5247 11922-11924 IN denotes by
T5248 11925-11933 JJ denotes standard
T5249 11934-11944 NN denotes procedures
T5250 11944-11945 -COMMA- denotes ,
T5251 11946-11951 CD denotes eight
T5252 11952-11958 NN denotes clones
T5253 11959-11963 IN denotes from
T5254 11964-11968 DT denotes each
T5255 11969-11975 NN denotes sample
T5256 11976-11980 VB denotes were
T5257 11981-11990 VB denotes sequenced
T5258 11991-11995 IN denotes with
T5259 11996-11998 DT denotes an
T5260 11999-12008 VB denotes automated
T5261 12009-12018 NN denotes sequencer
T5262 12019-12020 -LRB- denotes (
T5263 12020-12023 NNP denotes ABI
T5264 12024-12029 NNP denotes Prism
T5265 12030-12033 CD denotes 377
T5266 12033-12034 -COMMA- denotes ,
T5267 12035-12042 NNP denotes Applied
T5268 12043-12053 NNP denotes Biosystems
T5269 12053-12054 -RRB- denotes )
T5701 12057-12059 FW denotes In
T5702 12060-12065 FW denotes vitro
T5703 12066-12077 NN denotes methylation
T5704 12078-12081 CC denotes and
T5705 12082-12090 NN denotes reporter
T5706 12091-12095 NN denotes gene
T5707 12096-12102 NN denotes assays
T5708 12103-12106 DT denotes The
T5709 12107-12112 NN denotes IRF-4
T5710 12113-12130 JJ denotes promoter-reporter
T5711 12131-12135 NN denotes gene
T5712 12136-12145 NN denotes construct
T5713 12146-12149 VB denotes was
T5714 12150-12160 RB denotes generously
T5715 12161-12169 VB denotes provided
T5716 12170-12172 IN denotes by
T5717 12173-12175 NNP denotes J.
T5718 12176-12183 NNP denotes Hiscott
T5719 12184-12185 -LRB- denotes (
T5720 12185-12187 CD denotes 31
T5721 12187-12188 -RRB- denotes )
T5722 12190-12200 NN denotes Constructs
T5723 12201-12205 VB denotes were
T5724 12206-12216 VB denotes methylated
T5725 12217-12219 FW denotes in
T5726 12220-12225 FW denotes vitro
T5727 12226-12230 IN denotes with
T5728 12231-12234 NN denotes CpG
T5729 12235-12244 NN denotes Methylase
T5730 12245-12246 -LRB- denotes (
T5731 12246-12251 NN denotes M.Sss
T5732 12252-12253 CD denotes I
T5733 12253-12254 -RRB- denotes )
T5734 12255-12257 IN denotes as
T5735 12258-12269 VB denotes recommended
T5736 12270-12272 IN denotes by
T5737 12273-12276 DT denotes the
T5738 12277-12289 NN denotes manufacturer
T5739 12290-12291 -LRB- denotes (
T5740 12291-12293 NN denotes NE
T5741 12294-12301 NN denotes Biolabs
T5742 12301-12302 -RRB- denotes )
T5743 12303-12306 CC denotes and
T5744 12307-12315 JJ denotes complete
T5745 12316-12327 NN denotes methylation
T5746 12328-12331 VB denotes was
T5747 12332-12339 VB denotes checked
T5748 12340-12343 IN denotes via
T5749 12344-12355 NN denotes restriction
T5750 12356-12364 NN denotes analysis
T5751 12365-12366 -LRB- denotes (
T5752 12366-12372 NN denotes Figure
T5753 12373-12375 NN denotes 5A
T5754 12375-12376 -RRB- denotes )
T5755 12378-12386 NN denotes Reporter
T5756 12387-12391 NN denotes gene
T5757 12392-12398 NN denotes assays
T5758 12399-12404 VB denotes using
T5759 12405-12408 DT denotes the
T5760 12409-12413 JJ denotes dual
T5761 12414-12424 NN denotes luciferase
T5762 12425-12430 NN denotes assay
T5763 12431-12432 -LRB- denotes (
T5764 12432-12439 NN denotes Promega
T5765 12439-12440 -RRB- denotes )
T5766 12441-12445 VB denotes were
T5767 12446-12455 VB denotes performed
T5768 12456-12463 JJ denotes similar
T5769 12464-12466 TO denotes to
T5770 12467-12475 JJ denotes previous
T5771 12476-12483 NN denotes reports
T5772 12484-12485 -LRB- denotes (
T5773 12485-12487 CD denotes 29
T5774 12487-12488 -RRB- denotes )
T5775 12490-12497 RB denotes Briefly
T5776 12497-12498 -COMMA- denotes ,
T5777 12499-12500 CD denotes 5
T5778 12501-12503 NN denotes nM
T5779 12504-12506 IN denotes of
T5780 12507-12510 DT denotes the
T5781 12511-12519 NN denotes reporter
T5782 12520-12529 NN denotes construct
T5783 12530-12533 CC denotes and
T5784 12534-12537 DT denotes the
T5785 12538-12550 NN denotes transfection
T5786 12551-12558 NN denotes control
T5787 12559-12568 NN denotes construct
T5788 12569-12579 VB denotes expressing
T5789 12580-12583 DT denotes the
T5790 12584-12591 NN denotes renilla
T5791 12592-12602 NN denotes luciferase
T5792 12603-12607 NN denotes gene
T5793 12608-12612 VB denotes were
T5794 12613-12636 VB denotes transientlyco-expressed
T5795 12637-12640 IN denotes via
T5796 12641-12656 NN denotes electroporation
T5797 12658-12661 DT denotes The
T5798 12662-12669 NN denotes control
T5799 12670-12679 NN denotes construct
T5800 12680-12686 VB denotes served
T5801 12687-12689 IN denotes as
T5802 12690-12692 DT denotes an
T5803 12693-12701 JJ denotes internal
T5804 12702-12711 NN denotes reference
T5805 12712-12715 IN denotes for
T5806 12716-12728 NN denotes transfection
T5807 12729-12739 NN denotes efficiency
T5808 12741-12752 CD denotes Forty-eight
T5809 12753-12758 NN denotes hours
T5810 12759-12764 IN denotes after
T5811 12765-12777 NN denotes transfection
T5812 12777-12778 -COMMA- denotes ,
T5813 12779-12789 NN denotes luciferase
T5814 12790-12798 NN denotes activity
T5815 12799-12802 VB denotes was
T5816 12803-12811 VB denotes measured
T5817 12812-12816 IN denotes with
T5818 12817-12818 DT denotes a
T5819 12819-12821 NN denotes LB
T5820 12822-12824 CD denotes 96
T5821 12825-12826 NN denotes P
T5822 12827-12837 NN denotes microlumat
T5823 12838-12839 -LRB- denotes (
T5824 12839-12841 NNP denotes EG
T5825 12841-12842 CC denotes &
T5826 12842-12843 NNP denotes G
T5827 12844-12852 NNP denotes Berthold
T5828 12852-12853 -COMMA- denotes ,
T5829 12854-12857 NNP denotes Bad
T5830 12858-12865 NNP denotes Wildbad
T5831 12865-12866 -COMMA- denotes ,
T5832 12867-12874 NNP denotes Germany
T5833 12874-12875 -RRB- denotes )
T5834 12877-12882 NN denotes IRF-4
T5835 12883-12891 NN denotes promoter
T5836 12892-12902 NN denotes activation
T5837 12903-12906 VB denotes was
T5838 12907-12917 VB denotes quantified
T5839 12918-12920 IN denotes as
T5840 12921-12922 DT denotes a
T5841 12923-12928 NN denotes ratio
T5842 12929-12931 IN denotes of
T5843 12932-12940 VB denotes measured
T5844 12941-12948 RB denotes firefly
T5845 12949-12954 JJ denotes light
T5846 12955-12960 NN denotes units
T5847 12961-12962 -LRB- denotes (
T5848 12962-12965 NN denotes flu
T5849 12965-12966 -RRB- denotes )
T5850 12967-12975 JJ denotes relative
T5851 12976-12978 TO denotes to
T5852 12979-12986 NN denotes renilla
T5853 12987-12988 -LRB- denotes (
T5854 12988-12991 NN denotes rlu
T5855 12991-12992 -RRB- denotes )
T5856 12994-12998 DT denotes Each
T5857 12999-13009 NN denotes experiment
T5858 13010-13013 VB denotes was
T5859 13014-13021 VB denotes carried
T5860 13022-13025 RP denotes out
T5861 13026-13028 IN denotes at
T5862 13029-13034 JJ denotes least
T5863 13035-13040 CD denotes three
T5864 13041-13046 NN denotes times
T6221 13058-13065 NN denotes Absence
T6222 13066-13068 IN denotes of
T6223 13069-13074 NN denotes IRF-4
T6224 13075-13085 NN denotes expression
T6225 13086-13088 IN denotes in
T6226 13089-13097 NN denotes leukemia
T6227 13098-13103 NN denotes cells
T6228 13104-13106 VB denotes is
T6229 13107-13110 RB denotes not
T6230 13111-13114 JJ denotes due
T6231 13115-13117 TO denotes to
T6232 13118-13126 NN denotes promoter
T6233 13127-13138 NN denotes alterations
T6234 13139-13141 PRP denotes We
T6235 13142-13146 VB denotes have
T6236 13147-13157 RB denotes previously
T6237 13158-13170 VB denotes demonstrated
T6238 13171-13172 DT denotes a
T6239 13173-13177 NN denotes lack
T6240 13178-13180 IN denotes of
T6241 13181-13186 NN denotes IRF-4
T6242 13187-13197 NN denotes expression
T6243 13198-13200 IN denotes in
T6244 13201-13209 NN denotes leukemia
T6245 13210-13218 NN denotes patients
T6246 13219-13222 CC denotes and
T6247 13223-13235 RB denotes specifically
T6248 13236-13238 IN denotes in
T6249 13239-13242 NN denotes CML
T6250 13243-13250 NN denotes T-cells
T6251 13251-13252 -LRB- denotes (
T6252 13252-13253 CD denotes 3
T6253 13253-13254 -RRB- denotes )
T6254 13256-13260 RB denotes Here
T6255 13260-13261 -COMMA- denotes ,
T6256 13262-13264 PRP denotes we
T6257 13265-13276 VB denotes demonstrate
T6258 13277-13280 DT denotes the
T6259 13281-13288 NN denotes absence
T6260 13289-13291 IN denotes of
T6261 13292-13297 NN denotes IRF-4
T6262 13298-13308 NN denotes expression
T6263 13309-13311 IN denotes in
T6264 13312-13319 JJ denotes various
T6265 13320-13333 JJ denotes hematopoietic
T6266 13334-13338 NN denotes cell
T6267 13339-13344 NN denotes lines
T6268 13344-13345 -COMMA- denotes ,
T6269 13346-13350 JJ denotes such
T6270 13351-13353 IN denotes as
T6271 13354-13360 NN denotes Jurkat
T6272 13360-13361 -COMMA- denotes ,
T6273 13362-13363 DT denotes a
T6274 13364-13370 NN denotes T-cell
T6275 13371-13379 NN denotes leukemia
T6276 13379-13380 -COMMA- denotes ,
T6277 13381-13387 NN denotes CML-T1
T6278 13387-13388 -COMMA- denotes ,
T6279 13389-13390 DT denotes a
T6280 13391-13407 JJ denotes bcr-abl-positive
T6281 13408-13414 NN denotes T-cell
T6282 13415-13419 NN denotes line
T6283 13419-13420 -COMMA- denotes ,
T6284 13421-13426 NN denotes K-562
T6285 13426-13427 -COMMA- denotes ,
T6286 13428-13429 DT denotes a
T6287 13430-13445 JJ denotes bcr-abl-positve
T6288 13446-13461 NN denotes erythroleukemia
T6289 13461-13462 -COMMA- denotes ,
T6290 13463-13468 NN denotes U-937
T6291 13468-13469 -COMMA- denotes ,
T6292 13470-13471 DT denotes a
T6293 13472-13481 JJ denotes monocytic
T6294 13482-13490 NN denotes leukemia
T6295 13490-13491 -COMMA- denotes ,
T6296 13492-13496 NN denotes EM-2
T6297 13497-13500 CC denotes and
T6298 13501-13508 NN denotes LAMA-84
T6299 13508-13509 -COMMA- denotes ,
T6300 13510-13525 JJ denotes bcr-abl-positve
T6301 13526-13533 JJ denotes myeloid
T6302 13534-13542 NN denotes leukemia
T6303 13542-13543 -COMMA- denotes ,
T6304 13544-13547 CC denotes but
T6305 13548-13551 RB denotes not
T6306 13552-13554 IN denotes in
T6307 13555-13559 NN denotes SD-1
T6308 13559-13560 -COMMA- denotes ,
T6309 13561-13562 DT denotes a
T6310 13563-13579 JJ denotes bcr-abl-positive
T6311 13580-13585 JJ denotes acute
T6312 13586-13599 JJ denotes lymphoblastic
T6313 13600-13608 NN denotes leukemia
T6314 13609-13610 -LRB- denotes (
T6315 13610-13613 JJ denotes pre
T6316 13614-13619 NN denotes B-ALL
T6317 13619-13620 -RRB- denotes )
T6318 13620-13621 -COMMA- denotes ,
T6319 13622-13631 NN denotes RPMI-8226
T6320 13631-13632 -COMMA- denotes ,
T6321 13633-13634 DT denotes a
T6322 13635-13643 JJ denotes multiple
T6323 13644-13651 NN denotes myeloma
T6324 13652-13655 CC denotes and
T6325 13656-13662 NN denotes BV-173
T6326 13662-13663 -COMMA- denotes ,
T6327 13664-13665 DT denotes a
T6328 13666-13682 JJ denotes bcr-abl-positive
T6329 13683-13689 NN denotes B-cell
T6330 13690-13694 NN denotes line
T6331 13695-13696 -LRB- denotes (
T6332 13696-13703 NN denotes Figures
T6333 13704-13706 NN denotes 1A
T6334 13707-13710 CC denotes and
T6335 13711-13713 NN denotes 5D
T6336 13713-13714 -RRB- denotes )
T6337 13716-13721 IN denotes After
T6338 13722-13732 NN denotes sequencing
T6339 13733-13735 IN denotes of
T6340 13736-13739 DT denotes the
T6341 13740-13745 NN denotes IRF-4
T6342 13746-13754 NN denotes promoter
T6343 13754-13755 -COMMA- denotes ,
T6344 13756-13758 PRP denotes it
T6345 13759-13764 MD denotes could
T6346 13765-13767 VB denotes be
T6347 13768-13776 VB denotes excluded
T6348 13777-13781 IN denotes that
T6349 13782-13789 NN denotes absence
T6350 13790-13792 IN denotes of
T6351 13793-13798 NN denotes IRF-4
T6352 13799-13809 NN denotes expression
T6353 13810-13812 IN denotes in
T6354 13813-13816 DT denotes any
T6355 13817-13819 IN denotes of
T6356 13820-13823 DT denotes the
T6357 13824-13829 JJ denotes above
T6358 13830-13834 NN denotes cell
T6359 13835-13840 NN denotes lines
T6360 13841-13844 VB denotes was
T6361 13845-13848 JJ denotes due
T6362 13849-13851 TO denotes to
T6363 13852-13859 JJ denotes genetic
T6364 13860-13871 NN denotes aberrations
T6365 13873-13880 RB denotes However
T6366 13880-13881 -COMMA- denotes ,
T6367 13882-13883 CD denotes 2
T6368 13884-13886 NN denotes bp
T6369 13887-13894 NN denotes changes
T6370 13895-13896 -LRB- denotes (
T6371 13896-13906 NN denotes nucleotide
T6372 13907-13912 NN denotes −1081
T6373 13912-13913 -COMMA- denotes ,
T6374 13914-13917 NN denotes T→C
T6375 13918-13921 CC denotes and
T6376 13922-13927 CD denotes −1068
T6377 13927-13928 -COMMA- denotes ,
T6378 13929-13932 NN denotes A→C
T6379 13932-13933 -RRB- denotes )
T6380 13934-13939 MD denotes could
T6381 13940-13942 VB denotes be
T6382 13943-13951 VB denotes detected
T6383 13952-13954 IN denotes in
T6384 13955-13959 CC denotes both
T6385 13960-13963 DT denotes the
T6386 13964-13978 JJ denotes IRF-4-positive
T6387 13979-13985 NN denotes BV-173
T6388 13986-13989 CC denotes and
T6389 13990-13993 DT denotes the
T6390 13994-14008 JJ denotes IRF-4-negative
T6391 14009-14016 NN denotes LAMA-84
T6392 14016-14017 -COMMA- denotes ,
T6393 14018-14022 NN denotes EM-2
T6394 14023-14026 CC denotes and
T6395 14027-14032 NN denotes K-562
T6396 14033-14034 -LRB- denotes (
T6397 14034-14040 NN denotes Figure
T6398 14041-14043 NN denotes 1B
T6399 14043-14044 -RRB- denotes )
T6400 14046-14048 IN denotes At
T6401 14049-14057 NN denotes position
T6402 14058-14062 CD denotes −116
T6403 14063-14065 DT denotes an
T6404 14066-14069 NN denotes A→C
T6405 14070-14082 NN denotes substitution
T6406 14083-14086 VB denotes was
T6407 14087-14092 VB denotes found
T6408 14093-14095 IN denotes in
T6409 14096-14100 NN denotes EM-2
T6410 14100-14101 -COMMA- denotes ,
T6411 14102-14107 NN denotes K-562
T6412 14108-14111 CC denotes and
T6413 14112-14118 NN denotes CML-T1
T6414 14118-14119 -COMMA- denotes ,
T6415 14120-14127 IN denotes whereas
T6416 14128-14134 NN denotes Jurkat
T6417 14134-14135 -COMMA- denotes ,
T6418 14136-14142 NN denotes BV-173
T6419 14143-14146 CC denotes and
T6420 14147-14151 NN denotes SD-1
T6421 14152-14161 VB denotes exhibited
T6422 14162-14163 DT denotes a
T6423 14164-14169 VB denotes mixed
T6424 14170-14173 NN denotes A/C
T6425 14174-14182 NN denotes sequence
T6426 14183-14186 CC denotes and
T6427 14187-14192 NN denotes U-937
T6428 14192-14193 -COMMA- denotes ,
T6429 14194-14201 NN denotes LAMA-84
T6430 14202-14205 CC denotes and
T6431 14206-14215 NN denotes RPMI-8226
T6432 14216-14218 DT denotes no
T6433 14219-14231 NN denotes substitution
T6434 14232-14234 IN denotes at
T6435 14235-14238 DT denotes all
T6436 14239-14240 -LRB- denotes (
T6437 14240-14246 NN denotes Figure
T6438 14247-14249 NN denotes 1B
T6439 14249-14250 -RRB- denotes )
T6440 14252-14264 RB denotes Consequently
T6441 14264-14265 -COMMA- denotes ,
T6442 14266-14271 DT denotes these
T6443 14272-14283 NN denotes alterations
T6444 14284-14287 VB denotes are
T6445 14288-14296 JJ denotes unlikely
T6446 14297-14299 TO denotes to
T6447 14300-14306 VB denotes affect
T6448 14307-14312 NN denotes IRF-4
T6449 14313-14323 NN denotes expression
T7025 14326-14334 NN denotes Increase
T7026 14335-14337 IN denotes of
T7027 14338-14343 NN denotes IRF-4
T7028 14344-14354 NN denotes expression
T7029 14355-14357 IN denotes in
T7030 14358-14371 JJ denotes hematopoietic
T7031 14372-14377 NN denotes cells
T7032 14378-14383 IN denotes after
T7033 14384-14397 VB denotes demethylating
T7034 14398-14407 NN denotes treatment
T7035 14408-14410 PRP denotes We
T7036 14411-14415 RB denotes next
T7037 14416-14424 VB denotes analyzed
T7038 14425-14432 IN denotes whether
T7039 14433-14441 NN denotes promoter
T7040 14442-14453 NN denotes methylation
T7041 14454-14459 MD denotes could
T7042 14460-14462 VB denotes be
T7043 14463-14474 JJ denotes responsible
T7044 14475-14478 IN denotes for
T7045 14479-14494 NN denotes down-regulation
T7046 14495-14497 IN denotes of
T7047 14498-14503 NN denotes IRF-4
T7048 14504-14514 NN denotes expression
T7049 14516-14517 DT denotes A
T7050 14518-14524 NN denotes region
T7051 14525-14534 VB denotes including
T7052 14535-14540 NN denotes exon1
T7053 14541-14543 IN denotes in
T7054 14544-14547 DT denotes the
T7055 14548-14553 NN denotes IRF-4
T7056 14554-14562 NN denotes promoter
T7057 14563-14572 VB denotes exhibited
T7058 14573-14574 DT denotes a
T7059 14575-14580 JJ denotes large
T7060 14581-14587 NN denotes number
T7061 14588-14590 IN denotes of
T7062 14591-14599 JJ denotes CpG-rich
T7063 14600-14609 NN denotes sequences
T7064 14610-14611 -LRB- denotes (
T7065 14611-14617 NN denotes Figure
T7066 14618-14620 NN denotes 3A
T7067 14620-14621 -RRB- denotes )
T7068 14623-14630 JJ denotes Several
T7069 14631-14639 JJ denotes chemical
T7070 14640-14650 NN denotes substances
T7071 14651-14655 JJ denotes such
T7072 14656-14658 IN denotes as
T7073 14659-14680 NN denotes 5-aza-2-deoxycytidine
T7074 14681-14682 -LRB- denotes (
T7075 14682-14687 NN denotes AzadC
T7076 14687-14688 -RRB- denotes )
T7077 14689-14691 CC denotes or
T7078 14692-14705 NN denotes 5-azacytidine
T7079 14706-14707 -LRB- denotes (
T7080 14707-14711 NN denotes AzaC
T7081 14711-14712 -RRB- denotes )
T7082 14713-14720 VB denotes inhibit
T7083 14721-14723 FW denotes de
T7084 14724-14728 FW denotes novo
T7085 14729-14732 CC denotes and
T7086 14733-14744 NN denotes maintenance
T7087 14745-14756 NN denotes methylation
T7088 14756-14757 -COMMA- denotes ,
T7089 14758-14761 CC denotes and
T7090 14762-14766 RB denotes thus
T7091 14767-14770 MD denotes can
T7092 14771-14773 VB denotes be
T7093 14774-14778 VB denotes used
T7094 14779-14781 TO denotes to
T7095 14782-14789 VB denotes discern
T7096 14790-14798 NN denotes promoter
T7097 14799-14810 NN denotes methylation
T7098 14811-14812 -LRB- denotes (
T7099 14812-14817 CD denotes 32,33
T7100 14817-14818 -RRB- denotes )
T7101 14820-14822 PRP denotes We
T7102 14823-14827 VB denotes used
T7103 14828-14833 NN denotes AzadC
T7104 14834-14836 TO denotes to
T7105 14837-14845 VB denotes generate
T7106 14846-14858 JJ denotes unmethylated
T7107 14859-14862 NN denotes DNA
T7108 14864-14865 DT denotes A
T7109 14866-14868 CD denotes 72
T7110 14869-14870 NN denotes h
T7111 14871-14886 NN denotes AzadC-treatment
T7112 14887-14895 VB denotes resulted
T7113 14896-14898 IN denotes in
T7114 14899-14900 DT denotes a
T7115 14901-14924 JJ denotes concentration-dependent
T7116 14925-14935 NN denotes activation
T7117 14936-14938 IN denotes of
T7118 14939-14944 NN denotes IRF-4
T7119 14945-14958 NN denotes transcription
T7120 14959-14961 IN denotes in
T7121 14962-14968 NN denotes Jurkat
T7122 14969-14972 CC denotes and
T7123 14973-14979 NN denotes CML-T1
T7124 14980-14987 NN denotes T-cells
T7125 14988-14990 RB denotes as
T7126 14991-14995 RB denotes well
T7127 14996-14998 IN denotes as
T7128 14999-15001 IN denotes in
T7129 15002-15007 NN denotes U-937
T7130 15007-15008 -COMMA- denotes ,
T7131 15009-15014 NN denotes K-562
T7132 15015-15018 CC denotes and
T7133 15019-15023 NN denotes EM-2
T7134 15024-15028 NN denotes cell
T7135 15029-15034 NN denotes lines
T7136 15035-15036 -LRB- denotes (
T7137 15036-15042 NN denotes Figure
T7138 15043-15045 NN denotes 2A
T7139 15045-15046 -RRB- denotes )
T7140 15048-15053 NN denotes IRF-4
T7141 15054-15067 NN denotes transcription
T7142 15068-15071 VB denotes was
T7143 15072-15079 VB denotes induced
T7144 15080-15082 IN denotes in
T7145 15083-15084 DT denotes a
T7146 15085-15099 JJ denotes time-dependent
T7147 15100-15106 NN denotes manner
T7148 15107-15110 CC denotes and
T7149 15111-15114 VB denotes was
T7150 15115-15123 VB denotes observed
T7151 15124-15126 RB denotes as
T7152 15127-15132 RB denotes early
T7153 15133-15135 IN denotes as
T7154 15136-15138 CD denotes 24
T7155 15139-15140 NN denotes h
T7156 15141-15146 IN denotes after
T7157 15147-15156 NN denotes treatment
T7158 15157-15161 IN denotes with
T7159 15162-15167 NN denotes AzadC
T7160 15168-15171 CC denotes and
T7161 15172-15181 VB denotes increased
T7162 15182-15186 IN denotes over
T7163 15187-15191 NN denotes time
T7164 15192-15197 IN denotes until
T7165 15198-15200 CD denotes 72
T7166 15201-15202 NN denotes h
T7167 15203-15204 -LRB- denotes (
T7168 15204-15210 NN denotes Figure
T7169 15211-15213 NN denotes 2B
T7170 15213-15214 -RRB- denotes )
T7171 15216-15220 NN denotes Time
T7172 15221-15224 CC denotes and
T7173 15225-15233 NN denotes strength
T7174 15234-15236 IN denotes of
T7175 15237-15240 DT denotes the
T7176 15241-15251 NN denotes appearance
T7177 15252-15254 IN denotes of
T7178 15255-15260 NN denotes IRF-4
T7179 15261-15272 NN denotes transcripts
T7180 15273-15279 VB denotes varied
T7181 15280-15285 IN denotes among
T7182 15286-15290 NN denotes cell
T7183 15291-15296 NN denotes lines
T7184 15296-15297 -COMMA- denotes ,
T7185 15298-15302 FW denotes i.e.
T7186 15303-15309 NN denotes CML-T1
T7187 15310-15319 VB denotes responded
T7188 15320-15329 JJ denotes strongest
T7189 15330-15332 TO denotes to
T7190 15333-15348 NN denotes AzadC-treatment
T7191 15349-15350 -LRB- denotes (
T7192 15350-15354 NN denotes data
T7193 15355-15358 RB denotes not
T7194 15359-15364 VB denotes shown
T7195 15364-15365 -RRB- denotes )
T7196 15367-15369 IN denotes In
T7197 15370-15374 NN denotes line
T7198 15375-15379 IN denotes with
T7199 15380-15384 DT denotes this
T7200 15384-15385 -COMMA- denotes ,
T7201 15386-15401 NN denotes AzadC-treatment
T7202 15402-15404 IN denotes of
T7203 15405-15411 NN denotes CML-T1
T7204 15412-15415 CC denotes and
T7205 15416-15423 NN denotes LAMA-84
T7206 15424-15429 NN denotes cells
T7207 15430-15434 RB denotes also
T7208 15435-15445 VB denotes translated
T7209 15446-15448 IN denotes in
T7210 15449-15451 DT denotes an
T7211 15452-15461 NN denotes induction
T7212 15462-15464 IN denotes of
T7213 15465-15470 NN denotes IRF-4
T7214 15471-15478 NN denotes protein
T7215 15479-15489 NN denotes expression
T7216 15490-15491 -LRB- denotes (
T7217 15491-15497 NN denotes Figure
T7218 15498-15500 NN denotes 2C
T7219 15500-15501 -RRB- denotes )
T7220 15503-15514 RB denotes Accordingly
T7221 15514-15515 -COMMA- denotes ,
T7222 15516-15525 NN denotes treatment
T7223 15526-15528 IN denotes of
T7224 15529-15532 DT denotes the
T7225 15533-15547 JJ denotes IRF-4-positive
T7226 15548-15552 NN denotes cell
T7227 15553-15557 NN denotes line
T7228 15558-15564 NN denotes BV-173
T7229 15564-15565 -COMMA- denotes ,
T7230 15566-15570 NN denotes SD-1
T7231 15571-15574 CC denotes and
T7232 15575-15584 NN denotes RPMI-8226
T7233 15585-15589 IN denotes with
T7234 15590-15595 NN denotes AzadC
T7235 15596-15599 VB denotes had
T7236 15600-15602 DT denotes no
T7237 15603-15609 NN denotes effect
T7238 15610-15612 IN denotes on
T7239 15613-15618 NN denotes IRF-4
T7240 15619-15629 NN denotes expression
T7241 15630-15631 -LRB- denotes (
T7242 15631-15637 NN denotes Figure
T7243 15638-15640 NN denotes 2D
T7244 15640-15641 -RRB- denotes )
T7245 15643-15648 EX denotes There
T7246 15649-15652 VB denotes was
T7247 15653-15655 DT denotes no
T7248 15656-15666 NN denotes difference
T7249 15667-15669 IN denotes in
T7250 15670-15673 DT denotes the
T7251 15674-15681 NN denotes effects
T7252 15682-15684 IN denotes of
T7253 15685-15689 NN denotes AzaC
T7254 15690-15696 IN denotes versus
T7255 15697-15702 NN denotes AzadC
T7256 15702-15703 -COMMA- denotes ,
T7257 15704-15706 IN denotes as
T7258 15707-15711 DT denotes both
T7259 15712-15721 VB denotes increased
T7260 15722-15725 DT denotes the
T7261 15726-15731 NN denotes IRF-4
T7262 15732-15736 NN denotes mRNA
T7263 15737-15742 NN denotes level
T7264 15743-15745 IN denotes in
T7265 15746-15752 NN denotes CML-T1
T7266 15753-15758 NN denotes cells
T7267 15759-15761 RB denotes as
T7268 15762-15766 RB denotes well
T7269 15767-15768 -LRB- denotes (
T7270 15768-15772 NN denotes data
T7271 15773-15776 RB denotes not
T7272 15777-15782 VB denotes shown
T7273 15782-15783 -RRB- denotes )
T7274 15785-15789 DT denotes This
T7275 15790-15797 VB denotes implied
T7276 15798-15802 IN denotes that
T7277 15803-15811 NN denotes promoter
T7278 15812-15823 NN denotes methylation
T7279 15824-15827 MD denotes may
T7280 15828-15835 VB denotes control
T7281 15836-15841 NN denotes IRF-4
T7282 15842-15852 NN denotes expression
T7283 15852-15853 -COMMA- denotes ,
T7284 15854-15857 CC denotes but
T7285 15858-15860 DT denotes an
T7286 15861-15872 JJ denotes alternative
T7287 15873-15884 NN denotes explanation
T7288 15885-15888 MD denotes may
T7289 15889-15891 VB denotes be
T7290 15892-15902 NN denotes activation
T7291 15903-15905 IN denotes of
T7292 15906-15914 JJ denotes positive
T7293 15915-15930 JJ denotes transcriptional
T7294 15931-15941 NN denotes regulators
T7295 15942-15944 IN denotes of
T7296 15945-15950 NN denotes IRF-4
T7297 15951-15953 IN denotes by
T7298 15954-15959 NN denotes AzadC
T7299 15960-15961 -LRB- denotes (
T7300 15961-15963 CC denotes or
T7301 15964-15968 NN denotes AzaC
T7302 15968-15969 -RRB- denotes )
T7852 15972-15993 JJ denotes Methylation-sensitive
T7853 15994-16001 NN denotes enzymes
T7854 16002-16004 VB denotes do
T7855 16005-16008 RB denotes not
T7856 16009-16012 VB denotes cut
T7857 16013-16021 JJ denotes specific
T7858 16022-16027 NN denotes sites
T7859 16028-16030 IN denotes in
T7860 16031-16034 DT denotes the
T7861 16035-16040 NN denotes IRF-4
T7862 16041-16049 NN denotes promoter
T7863 16050-16052 IN denotes in
T7864 16053-16066 JJ denotes hematopoietic
T7865 16067-16072 NN denotes cells
T7866 16073-16075 TO denotes To
T7867 16076-16083 RB denotes further
T7868 16084-16095 VB denotes investigate
T7869 16096-16104 NN denotes promoter
T7870 16105-16116 NN denotes methylation
T7871 16117-16119 IN denotes as
T7872 16120-16121 DT denotes a
T7873 16122-16132 JJ denotes regulatory
T7874 16133-16142 NN denotes mechanism
T7875 16143-16145 IN denotes of
T7876 16146-16151 NN denotes IRF-4
T7877 16152-16156 NN denotes gene
T7878 16157-16167 NN denotes expression
T7879 16167-16168 -COMMA- denotes ,
T7880 16169-16191 NN denotes restriction-PCR-assays
T7881 16192-16196 VB denotes were
T7882 16197-16206 VB denotes performed
T7883 16207-16208 -LRB- denotes (
T7884 16208-16213 CD denotes 20,24
T7885 16213-16214 -RRB- denotes )
T7886 16214-16215 -COMMA- denotes ,
T7887 16216-16221 WRB denotes where
T7888 16222-16226 RB denotes only
T7889 16227-16237 VB denotes methylated
T7890 16238-16241 NN denotes DNA
T7891 16242-16247 MD denotes would
T7892 16248-16251 RB denotes not
T7893 16252-16254 VB denotes be
T7894 16255-16258 VB denotes cut
T7895 16259-16267 VB denotes enabling
T7896 16268-16278 JJ denotes subsequent
T7897 16279-16282 NN denotes PCR
T7898 16283-16296 NN denotes amplification
T7899 16297-16300 CC denotes and
T7900 16301-16305 NN denotes vice
T7901 16306-16311 NN denotes versa
T7902 16313-16320 JJ denotes Genomic
T7903 16321-16324 NN denotes DNA
T7904 16325-16329 IN denotes from
T7905 16330-16338 JJ denotes leukemic
T7906 16339-16344 NN denotes cells
T7907 16345-16351 NN denotes Jurkat
T7908 16351-16352 -COMMA- denotes ,
T7909 16353-16359 NN denotes CML-T1
T7910 16359-16360 -COMMA- denotes ,
T7911 16361-16366 NN denotes U-937
T7912 16366-16367 -COMMA- denotes ,
T7913 16368-16373 NN denotes K-562
T7914 16373-16374 -COMMA- denotes ,
T7915 16375-16379 NN denotes EM-2
T7916 16380-16383 CC denotes and
T7917 16384-16390 NN denotes BV-173
T7918 16391-16394 VB denotes was
T7919 16395-16403 VB denotes digested
T7920 16404-16408 IN denotes with
T7921 16409-16412 DT denotes the
T7922 16413-16434 JJ denotes methylation-sensitive
T7923 16435-16442 NN denotes enzymes
T7924 16443-16448 NN denotes HpaII
T7925 16448-16449 -COMMA- denotes ,
T7926 16450-16458 NN denotes Bsh1236I
T7927 16459-16462 CC denotes and
T7928 16463-16480 NN denotes HaeII-isochizomer
T7929 16481-16489 NN denotes Bsp143II
T7930 16491-16496 NNP denotes EcoRI
T7931 16496-16497 -COMMA- denotes ,
T7932 16498-16503 WDT denotes which
T7933 16504-16507 VB denotes has
T7934 16508-16510 DT denotes no
T7935 16511-16522 NN denotes recognition
T7936 16523-16527 NN denotes site
T7937 16528-16534 IN denotes within
T7938 16535-16538 DT denotes the
T7939 16539-16544 NN denotes IRF-4
T7940 16545-16553 NN denotes promoter
T7941 16553-16554 -COMMA- denotes ,
T7942 16555-16558 CC denotes and
T7943 16559-16562 DT denotes the
T7944 16563-16584 JJ denotes methylation-resistant
T7945 16585-16591 NN denotes enzyme
T7946 16592-16596 NN denotes MspI
T7947 16597-16603 VB denotes served
T7948 16604-16606 IN denotes as
T7949 16607-16615 NN denotes controls
T7950 16617-16620 CD denotes Two
T7951 16621-16629 JJ denotes separate
T7952 16630-16643 NN denotes amplification
T7953 16644-16653 NN denotes reactions
T7954 16654-16658 VB denotes were
T7955 16659-16668 VB denotes performed
T7956 16668-16669 -COMMA- denotes ,
T7957 16670-16680 VB denotes generating
T7958 16681-16684 CD denotes two
T7959 16685-16694 NN denotes fragments
T7960 16694-16695 -COMMA- denotes ,
T7961 16696-16698 NN denotes F1
T7962 16699-16702 CC denotes and
T7963 16703-16705 NN denotes F2
T7964 16706-16707 -LRB- denotes (
T7965 16707-16713 NN denotes Figure
T7966 16714-16716 NN denotes 3A
T7967 16716-16717 -RRB- denotes )
T7968 16719-16724 IN denotes After
T7969 16725-16734 NN denotes digestion
T7970 16735-16739 IN denotes with
T7971 16740-16745 NN denotes HpaII
T7972 16746-16749 CC denotes and
T7973 16750-16758 NN denotes Bsp143II
T7974 16759-16760 DT denotes a
T7975 16761-16771 JJ denotes sufficient
T7976 16772-16775 NN denotes PCR
T7977 16776-16789 NN denotes amplification
T7978 16790-16792 IN denotes of
T7979 16793-16795 NN denotes F1
T7980 16796-16799 CC denotes and
T7981 16800-16802 NN denotes F2
T7982 16803-16806 VB denotes was
T7983 16807-16815 VB denotes detected
T7984 16816-16818 IN denotes in
T7985 16819-16822 NN denotes DNA
T7986 16823-16827 IN denotes from
T7987 16828-16842 JJ denotes IRF-4-negative
T7988 16843-16849 NN denotes Jurkat
T7989 16849-16850 -COMMA- denotes ,
T7990 16851-16857 NN denotes CML-T1
T7991 16857-16858 -COMMA- denotes ,
T7992 16859-16864 NN denotes U-937
T7993 16864-16865 -COMMA- denotes ,
T7994 16866-16871 NN denotes K-562
T7995 16872-16875 CC denotes and
T7996 16876-16880 NN denotes EM-2
T7997 16881-16886 NN denotes cells
T7998 16886-16887 -COMMA- denotes ,
T7999 16888-16898 VB denotes suggesting
T8000 16899-16900 DT denotes a
T8001 16901-16909 NN denotes promoter
T8002 16910-16921 NN denotes methylation
T8003 16922-16923 -LRB- denotes (
T8004 16923-16926 CC denotes and
T8005 16927-16938 NN denotes restriction
T8006 16939-16949 NN denotes protection
T8007 16949-16950 -RRB- denotes )
T8008 16951-16953 IN denotes at
T8009 16954-16957 DT denotes the
T8010 16958-16968 JJ denotes respective
T8011 16969-16980 NN denotes recognition
T8012 16981-16986 NN denotes sites
T8013 16987-16988 -LRB- denotes (
T8014 16988-16994 NN denotes Figure
T8015 16995-16997 NN denotes 3B
T8016 16998-17001 CC denotes and
T8017 17002-17003 NN denotes C
T8018 17003-17004 -RRB- denotes )
T8019 17006-17013 RB denotes Notably
T8020 17013-17014 -COMMA- denotes ,
T8021 17015-17017 IN denotes in
T8022 17018-17032 JJ denotes IRF-4-positive
T8023 17033-17037 NN denotes SD-1
T8024 17038-17043 NN denotes cells
T8025 17044-17053 NN denotes digestion
T8026 17054-17058 IN denotes with
T8027 17059-17062 DT denotes the
T8028 17063-17084 JJ denotes methylation-sensitive
T8029 17085-17092 NN denotes enzymes
T8030 17093-17103 RB denotes completely
T8031 17104-17113 VB denotes inhibited
T8032 17114-17127 NN denotes amplification
T8033 17128-17130 IN denotes of
T8034 17131-17133 NN denotes F1
T8035 17134-17137 CC denotes and
T8036 17138-17140 NN denotes F2
T8037 17142-17144 IN denotes In
T8038 17145-17159 JJ denotes IRF-4-positive
T8039 17160-17166 NN denotes BV-173
T8040 17167-17172 NN denotes cells
T8041 17173-17174 DT denotes a
T8042 17175-17180 NN denotes HpaII
T8043 17180-17181 -COMMA- denotes ,
T8044 17182-17185 CC denotes but
T8045 17186-17189 RB denotes not
T8046 17190-17191 DT denotes a
T8047 17192-17200 NN denotes Bsh1236I
T8048 17201-17210 NN denotes digestion
T8049 17210-17211 -COMMA- denotes ,
T8050 17212-17225 RB denotes significantly
T8051 17226-17233 VB denotes reduced
T8052 17234-17237 DT denotes the
T8053 17238-17249 JJ denotes amplifiable
T8054 17250-17253 NN denotes DNA
T8055 17254-17261 NN denotes message
T8056 17262-17264 IN denotes of
T8057 17265-17267 NN denotes F2
T8058 17268-17269 -LRB- denotes (
T8059 17269-17275 NN denotes Figure
T8060 17276-17278 NN denotes 3C
T8061 17278-17279 -RRB- denotes )
T8062 17279-17280 -COMMA- denotes ,
T8063 17281-17288 IN denotes whereas
T8064 17289-17302 NN denotes amplification
T8065 17303-17305 IN denotes of
T8066 17306-17308 NN denotes F1
T8067 17309-17312 VB denotes was
T8068 17313-17316 RB denotes not
T8069 17317-17325 VB denotes affected
T8070 17326-17327 -LRB- denotes (
T8071 17327-17333 NN denotes Figure
T8072 17334-17336 NN denotes 3B
T8073 17336-17337 -RRB- denotes )
T8074 17339-17343 DT denotes This
T8075 17344-17351 VB denotes implied
T8076 17352-17356 IN denotes that
T8077 17357-17362 NN denotes IRF-4
T8078 17363-17376 NN denotes transcription
T8079 17377-17379 IN denotes in
T8080 17380-17384 NN denotes SD-1
T8081 17385-17388 CC denotes and
T8082 17389-17395 NN denotes BV-173
T8083 17396-17401 NN denotes cells
T8084 17402-17404 VB denotes is
T8085 17405-17415 VB denotes associated
T8086 17416-17420 IN denotes with
T8087 17421-17425 JJ denotes less
T8088 17426-17434 NN denotes promoter
T8089 17435-17446 NN denotes methylation
T8090 17447-17448 -LRB- denotes (
T8091 17448-17450 IN denotes in
T8092 17451-17457 NN denotes BV-173
T8093 17458-17468 RB denotes especially
T8094 17469-17471 IN denotes at
T8095 17472-17477 NN denotes HpaII
T8096 17478-17483 NN denotes sites
T8097 17483-17484 -RRB- denotes )
T8098 17485-17487 IN denotes as
T8099 17488-17496 VB denotes compared
T8100 17497-17501 IN denotes with
T8101 17502-17505 DT denotes the
T8102 17506-17512 VB denotes tested
T8103 17513-17527 JJ denotes IRF-4-negative
T8104 17528-17533 NN denotes cells
T8578 17536-17544 JJ denotes Specific
T8579 17545-17548 NN denotes CpG
T8580 17549-17554 NN denotes sites
T8581 17555-17557 IN denotes in
T8582 17558-17561 DT denotes the
T8583 17562-17567 NN denotes IRF-4
T8584 17568-17576 NN denotes promoter
T8585 17577-17580 VB denotes are
T8586 17581-17591 VB denotes methylated
T8587 17592-17594 IN denotes in
T8588 17595-17608 JJ denotes hematopoietic
T8589 17609-17614 NN denotes cells
T8590 17615-17617 IN denotes In
T8591 17618-17623 NN denotes order
T8592 17624-17626 TO denotes to
T8593 17627-17634 RB denotes exactly
T8594 17635-17638 VB denotes map
T8595 17639-17642 DT denotes the
T8596 17643-17654 NN denotes methylation
T8597 17655-17660 NN denotes sites
T8598 17661-17667 IN denotes within
T8599 17668-17671 DT denotes the
T8600 17672-17677 NN denotes IRF-4
T8601 17678-17686 NN denotes promoter
T8602 17686-17687 -COMMA- denotes ,
T8603 17688-17690 PRP denotes we
T8604 17691-17698 VB denotes treated
T8605 17699-17702 NN denotes DNA
T8606 17703-17705 IN denotes of
T8607 17706-17712 NN denotes Jurkat
T8608 17712-17713 -COMMA- denotes ,
T8609 17714-17720 NN denotes CML-T1
T8610 17720-17721 -COMMA- denotes ,
T8611 17722-17727 NN denotes U-937
T8612 17727-17728 -COMMA- denotes ,
T8613 17729-17734 NN denotes K-562
T8614 17735-17738 CC denotes and
T8615 17739-17743 NN denotes EM-2
T8616 17744-17749 NN denotes cells
T8617 17750-17752 RB denotes as
T8618 17753-17757 RB denotes well
T8619 17758-17760 IN denotes as
T8620 17761-17763 IN denotes of
T8621 17764-17768 NN denotes SD-1
T8622 17768-17769 -COMMA- denotes ,
T8623 17770-17779 NN denotes RPMI-8226
T8624 17780-17783 CC denotes and
T8625 17784-17790 NN denotes BV-173
T8626 17791-17798 NN denotes control
T8627 17799-17804 NN denotes cells
T8628 17805-17809 IN denotes with
T8629 17810-17819 NN denotes bisulfite
T8630 17819-17820 -COMMA- denotes ,
T8631 17821-17826 WDT denotes which
T8632 17827-17837 RB denotes chemically
T8633 17838-17846 VB denotes converts
T8634 17847-17859 JJ denotes unmethylated
T8635 17860-17868 NN denotes cytosine
T8636 17869-17871 TO denotes to
T8637 17872-17878 NN denotes uracil
T8638 17878-17879 -COMMA- denotes ,
T8639 17880-17887 IN denotes whereas
T8640 17888-17890 PRP denotes it
T8641 17891-17894 VB denotes has
T8642 17895-17897 DT denotes no
T8643 17898-17904 NN denotes effect
T8644 17905-17907 IN denotes on
T8645 17908-17918 VB denotes methylated
T8646 17919-17927 NN denotes cytosine
T8647 17927-17928 -COMMA- denotes ,
T8648 17929-17933 FW denotes i.e.
T8649 17934-17936 IN denotes in
T8650 17937-17940 NN denotes CpG
T8651 17941-17942 -LRB- denotes (
T8652 17942-17944 CD denotes 34
T8653 17944-17945 -RRB- denotes )
T8654 17947-17951 DT denotes This
T8655 17952-17961 NN denotes technique
T8656 17962-17964 VB denotes is
T8657 17965-17975 RB denotes especially
T8658 17976-17982 JJ denotes useful
T8659 17983-17986 IN denotes for
T8660 17987-17996 NN denotes detection
T8661 17997-17999 IN denotes of
T8662 18000-18007 JJ denotes unknown
T8663 18008-18019 NN denotes methylation
T8664 18020-18028 NN denotes patterns
T8665 18030-18033 NN denotes PCR
T8666 18034-18047 NN denotes amplification
T8667 18047-18048 -COMMA- denotes ,
T8668 18049-18056 NN denotes cloning
T8669 18057-18060 CC denotes and
T8670 18061-18071 NN denotes sequencing
T8671 18072-18074 IN denotes of
T8672 18075-18078 DT denotes the
T8673 18079-18096 JJ denotes bisulfite-treated
T8674 18097-18100 NN denotes DNA
T8675 18101-18107 VB denotes showed
T8676 18108-18109 DT denotes a
T8677 18110-18118 JJ denotes specific
T8678 18119-18130 NN denotes methylation
T8679 18131-18138 NN denotes pattern
T8680 18139-18141 IN denotes of
T8681 18142-18145 DT denotes the
T8682 18146-18154 VB denotes analyzed
T8683 18155-18157 CD denotes 62
T8684 18158-18161 NN denotes CpG
T8685 18162-18167 NN denotes sites
T8686 18168-18170 IN denotes in
T8687 18171-18174 DT denotes all
T8688 18175-18179 NN denotes cell
T8689 18180-18185 NN denotes lines
T8690 18186-18187 -LRB- denotes (
T8691 18187-18193 NN denotes Figure
T8692 18194-18195 CD denotes 4
T8693 18196-18199 CC denotes and
T8694 18200-18205 NN denotes Table
T8695 18206-18207 CD denotes 1
T8696 18207-18208 -RRB- denotes )
T8697 18210-18212 IN denotes In
T8698 18213-18220 JJ denotes general
T8699 18220-18221 -COMMA- denotes ,
T8700 18222-18225 DT denotes the
T8701 18226-18239 JJ denotes methylational
T8702 18240-18246 NN denotes status
T8703 18247-18253 VB denotes ranged
T8704 18254-18258 IN denotes from
T8705 18259-18262 CD denotes one
T8706 18263-18267 NN denotes cell
T8707 18268-18272 NN denotes line
T8708 18273-18277 IN denotes with
T8709 18278-18279 DT denotes a
T8710 18280-18286 RB denotes nearly
T8711 18287-18301 JJ denotes non-methylated
T8712 18302-18307 NN denotes IRF-4
T8713 18308-18316 NN denotes promoter
T8714 18317-18318 -LRB- denotes (
T8715 18318-18322 NN denotes SD-1
T8716 18322-18323 -COMMA- denotes ,
T8717 18324-18338 JJ denotes IRF-4-positive
T8718 18338-18339 -RRB- denotes )
T8719 18340-18342 TO denotes to
T8720 18343-18344 DT denotes a
T8721 18345-18355 RB denotes completely
T8722 18356-18366 VB denotes methylated
T8723 18367-18372 NN denotes IRF-4
T8724 18373-18381 NN denotes promoter
T8725 18382-18384 IN denotes in
T8726 18385-18391 NN denotes CML-T1
T8727 18392-18393 -LRB- denotes (
T8728 18393-18407 JJ denotes IRF-4-negative
T8729 18407-18408 -RRB- denotes )
T8730 18410-18423 RB denotes Interestingly
T8731 18423-18424 -COMMA- denotes ,
T8732 18425-18428 DT denotes the
T8733 18429-18439 NN denotes percentage
T8734 18440-18442 IN denotes of
T8735 18443-18446 NN denotes CpG
T8736 18447-18458 NN denotes methylation
T8737 18459-18461 IN denotes in
T8738 18462-18465 DT denotes the
T8739 18466-18471 NN denotes IRF-4
T8740 18472-18480 NN denotes promoter
T8741 18481-18485 IN denotes from
T8742 18486-18500 JJ denotes IRF-4-positive
T8743 18501-18506 NN denotes cells
T8744 18507-18510 VB denotes was
T8745 18511-18515 RB denotes very
T8746 18516-18519 JJ denotes low
T8747 18520-18521 -LRB- denotes (
T8748 18521-18525 NN denotes mean
T8749 18526-18528 CD denotes 24
T8750 18528-18529 NN denotes %
T8751 18529-18530 -RRB- denotes )
T8752 18531-18533 IN denotes as
T8753 18534-18542 VB denotes compared
T8754 18543-18547 IN denotes with
T8755 18548-18562 JJ denotes IRF-4-negative
T8756 18563-18568 NN denotes cells
T8757 18569-18570 -LRB- denotes (
T8758 18570-18574 NN denotes mean
T8759 18575-18577 CD denotes 94
T8760 18577-18578 NN denotes %
T8761 18578-18579 -RRB- denotes )
T8762 18580-18581 -LRB- denotes (
T8763 18581-18587 NN denotes Figure
T8764 18588-18590 NN denotes 4A
T8765 18591-18594 CC denotes and
T8766 18595-18600 JJ denotes Table
T8767 18601-18602 CD denotes 1
T8768 18602-18603 -RRB- denotes )
T8769 18605-18606 DT denotes A
T8770 18607-18616 NN denotes 5′-region
T8771 18617-18618 -LRB- denotes (
T8772 18618-18620 NN denotes R1
T8773 18620-18621 -RRB- denotes )
T8774 18622-18626 IN denotes with
T8775 18627-18629 CD denotes 13
T8776 18630-18645 VB denotes hypermethylated
T8777 18646-18649 NN denotes CpG
T8778 18650-18655 NN denotes sites
T8779 18656-18657 -LRB- denotes (
T8780 18657-18661 JJ denotes mean
T8781 18662-18668 NN denotes number
T8782 18669-18671 IN denotes of
T8783 18672-18682 VB denotes methylated
T8784 18683-18689 NN denotes clones
T8785 18690-18693 CD denotes 5.5
T8786 18694-18696 IN denotes of
T8787 18697-18698 CD denotes 8
T8788 18699-18703 IN denotes with
T8789 18704-18706 CD denotes 77
T8790 18706-18707 NN denotes %
T8791 18708-18718 VB denotes methylated
T8792 18719-18723 NN denotes CpGs
T8793 18723-18724 -RRB- denotes )
T8794 18725-18728 VB denotes was
T8795 18729-18734 VB denotes found
T8796 18735-18737 IN denotes in
T8797 18738-18742 JJ denotes most
T8798 18743-18748 NN denotes cells
T8799 18749-18750 -LRB- denotes (
T8800 18750-18756 IN denotes except
T8801 18757-18761 NN denotes SD-1
T8802 18762-18765 CC denotes and
T8803 18766-18775 NN denotes RPMI-8226
T8804 18775-18776 -RRB- denotes )
T8805 18777-18780 CC denotes and
T8806 18781-18782 DT denotes a
T8807 18783-18792 NN denotes 3′-region
T8808 18793-18794 -LRB- denotes (
T8809 18794-18796 NN denotes R3
T8810 18796-18797 -RRB- denotes )
T8811 18798-18800 IN denotes of
T8812 18801-18802 CD denotes 6
T8813 18803-18817 VB denotes hypomethylated
T8814 18818-18821 NN denotes CpG
T8815 18822-18827 NN denotes sites
T8816 18828-18829 -LRB- denotes (
T8817 18829-18833 JJ denotes mean
T8818 18834-18840 NN denotes number
T8819 18841-18843 IN denotes of
T8820 18844-18854 VB denotes methylated
T8821 18855-18861 NN denotes clones
T8822 18862-18865 CD denotes 1.7
T8823 18866-18868 IN denotes of
T8824 18869-18870 CD denotes 8
T8825 18871-18875 IN denotes with
T8826 18876-18878 CD denotes 33
T8827 18878-18879 NN denotes %
T8828 18880-18890 VB denotes methylated
T8829 18891-18895 NN denotes CpGs
T8830 18895-18896 -RRB- denotes )
T8831 18897-18900 VB denotes was
T8832 18901-18906 VB denotes found
T8833 18907-18909 IN denotes in
T8834 18910-18914 JJ denotes most
T8835 18915-18920 NN denotes cells
T8836 18921-18922 -LRB- denotes (
T8837 18922-18928 IN denotes except
T8838 18929-18935 NN denotes CML-T1
T8839 18936-18939 CC denotes and
T8840 18940-18945 NN denotes U-937
T8841 18945-18946 -RRB- denotes )
T8842 18947-18948 -LRB- denotes (
T8843 18948-18954 NN denotes Figure
T8844 18955-18957 NN denotes 4A
T8845 18958-18961 CC denotes and
T8846 18962-18967 JJ denotes Table
T8847 18968-18969 CD denotes 1
T8848 18969-18970 -RRB- denotes )
T8849 18972-18984 RB denotes Intriguingly
T8850 18984-18985 -COMMA- denotes ,
T8851 18986-18987 DT denotes a
T8852 18988-18995 NN denotes stretch
T8853 18996-18998 IN denotes of
T8854 18999-19001 CD denotes 13
T8855 19002-19005 NN denotes CpG
T8856 19006-19011 NN denotes sites
T8857 19012-19013 -LRB- denotes (
T8858 19013-19014 -SHARP- denotes #
T8859 19014-19019 CD denotes 10–22
T8860 19019-19020 -COLON- denotes ;
T8861 19021-19023 NN denotes R2
T8862 19023-19024 -RRB- denotes )
T8863 19025-19028 VB denotes was
T8864 19029-19037 VB denotes detected
T8865 19038-19040 IN denotes in
T8866 19041-19048 IN denotes between
T8867 19049-19054 DT denotes these
T8868 19055-19062 NN denotes regions
T8869 19062-19063 -COMMA- denotes ,
T8870 19064-19069 WDT denotes which
T8871 19070-19074 VB denotes were
T8872 19075-19081 RB denotes highly
T8873 19082-19092 VB denotes methylated
T8874 19093-19095 IN denotes in
T8875 19096-19110 JJ denotes IRF-4-negative
T8876 19111-19112 -LRB- denotes (
T8877 19112-19116 JJ denotes mean
T8878 19117-19123 NN denotes number
T8879 19124-19126 IN denotes of
T8880 19127-19137 VB denotes methylated
T8881 19138-19144 NN denotes clones
T8882 19145-19148 CD denotes 7.1
T8883 19149-19151 IN denotes of
T8884 19152-19153 CD denotes 8
T8885 19154-19158 IN denotes with
T8886 19159-19161 CD denotes 89
T8887 19161-19162 NN denotes %
T8888 19163-19173 VB denotes methylated
T8889 19174-19178 NN denotes CpGs
T8890 19178-19179 -RRB- denotes )
T8891 19180-19183 CC denotes but
T8892 19184-19191 RB denotes totally
T8893 19192-19206 JJ denotes non-methylated
T8894 19207-19209 IN denotes in
T8895 19210-19224 JJ denotes IRF-4-positive
T8896 19225-19230 NN denotes cells
T8897 19231-19232 -LRB- denotes (
T8898 19232-19238 NN denotes Figure
T8899 19239-19241 NN denotes 4A
T8900 19242-19245 CC denotes and
T8901 19246-19247 NN denotes B
T8902 19247-19248 -RRB- denotes )
T8903 19250-19261 RB denotes Furthermore
T8904 19261-19262 -COMMA- denotes ,
T8905 19263-19268 CD denotes three
T8906 19269-19272 NN denotes CpG
T8907 19273-19278 NN denotes sites
T8908 19279-19281 IN denotes at
T8909 19282-19285 DT denotes the
T8910 19286-19288 NN denotes 5′
T8911 19289-19292 NN denotes end
T8912 19293-19294 -LRB- denotes (
T8913 19294-19295 -SHARP- denotes #
T8914 19295-19297 CD denotes 54
T8915 19297-19298 -COMMA- denotes ,
T8916 19299-19301 CD denotes 56
T8917 19301-19302 -COMMA- denotes ,
T8918 19303-19305 CD denotes 58
T8919 19305-19306 -RRB- denotes )
T8920 19307-19310 CC denotes and
T8921 19311-19314 CD denotes two
T8922 19315-19318 NN denotes CpG
T8923 19319-19325 NN denotes motifs
T8924 19326-19328 IN denotes at
T8925 19329-19332 DT denotes the
T8926 19333-19335 NN denotes 3′
T8927 19336-19339 NN denotes end
T8928 19340-19341 -LRB- denotes (
T8929 19341-19342 -SHARP- denotes #
T8930 19342-19343 CD denotes 1
T8931 19343-19344 -COMMA- denotes ,
T8932 19345-19346 CD denotes 2
T8933 19346-19347 -RRB- denotes )
T8934 19348-19354 VB denotes showed
T8935 19355-19359 DT denotes this
T8936 19360-19366 JJ denotes direct
T8937 19367-19378 NN denotes correlation
T8938 19379-19386 IN denotes between
T8939 19387-19391 JJ denotes high
T8940 19392-19403 NN denotes methylation
T8941 19404-19410 NN denotes status
T8942 19411-19414 CC denotes and
T8943 19415-19422 NN denotes absence
T8944 19423-19425 IN denotes of
T8945 19426-19431 NN denotes IRF-4
T8946 19432-19442 NN denotes expression
T8947 19444-19446 IN denotes In
T8948 19447-19455 NN denotes addition
T8949 19455-19456 -COMMA- denotes ,
T8950 19457-19460 CD denotes two
T8951 19461-19464 NN denotes CpG
T8952 19465-19470 NN denotes sites
T8953 19471-19478 JJ denotes located
T8954 19479-19481 IN denotes in
T8955 19482-19483 DT denotes a
T8956 19484-19488 NN denotes NFκB
T8957 19489-19490 -LRB- denotes (
T8958 19490-19491 -SHARP- denotes #
T8959 19491-19493 CD denotes 48
T8960 19493-19494 -RRB- denotes )
T8961 19495-19498 CC denotes and
T8962 19499-19500 DT denotes a
T8963 19501-19504 NN denotes SP1
T8964 19505-19512 NN denotes element
T8965 19513-19514 -LRB- denotes (
T8966 19514-19515 -SHARP- denotes #
T8967 19515-19517 CD denotes 45
T8968 19517-19518 -RRB- denotes )
T8969 19519-19522 VB denotes are
T8970 19523-19527 RB denotes less
T8971 19528-19538 VB denotes methylated
T8972 19539-19541 IN denotes in
T8973 19542-19556 JJ denotes IRF-4-positive
T8974 19557-19561 IN denotes than
T8975 19562-19564 IN denotes in
T8976 19565-19579 JJ denotes IRF-4-negative
T8977 19580-19585 NN denotes cells
T8978 19586-19587 -LRB- denotes (
T8979 19587-19591 JJ denotes mean
T8980 19592-19598 NN denotes number
T8981 19599-19601 IN denotes of
T8982 19602-19612 VB denotes methylated
T8983 19613-19619 NN denotes clones
T8984 19619-19620 -COLON- denotes :
T8985 19621-19624 CD denotes 1/8
T8986 19625-19631 CC denotes versus
T8987 19632-19635 CD denotes 8/8
T8988 19635-19636 -RRB- denotes )
T8989 19638-19643 DT denotes These
T8990 19644-19651 NN denotes results
T8991 19652-19660 VB denotes indicate
T8992 19661-19664 DT denotes the
T8993 19665-19676 NN denotes involvement
T8994 19677-19679 IN denotes of
T8995 19680-19683 NN denotes CpG
T8996 19684-19695 NN denotes methylation
T8997 19696-19698 IN denotes in
T8998 19699-19702 DT denotes the
T8999 19703-19713 NN denotes regulation
T9000 19714-19716 IN denotes of
T9001 19717-19722 NN denotes IRF-4
T9002 19723-19733 NN denotes expression
T9003 19734-19736 IN denotes in
T9004 19737-19745 JJ denotes leukemic
T9005 19746-19751 NN denotes cells
T11862 24760-24768 VB denotes inhibits
T9706 19754-19756 FW denotes In
T9707 19757-19762 FW denotes vitro
T9708 19763-19774 NN denotes methylation
T9709 19775-19777 IN denotes of
T9710 19778-19780 DT denotes an
T9711 19781-19786 NN denotes IRF-4
T9712 19787-19804 JJ denotes promoter-reporter
T9713 19805-19814 NN denotes construct
T9714 19815-19824 VB denotes decreases
T9715 19825-19828 PRP-DOLLAR- denotes its
T9716 19829-19837 NN denotes activity
T9717 19838-19840 TO denotes To
T9718 19841-19848 VB denotes provide
T9719 19849-19857 NN denotes evidence
T9720 19858-19861 IN denotes for
T9721 19862-19863 DT denotes a
T9722 19864-19870 JJ denotes direct
T9723 19871-19877 NN denotes effect
T9724 19878-19880 IN denotes of
T9725 19881-19894 JJ denotes methylational
T9726 19895-19901 NN denotes status
T9727 19902-19904 IN denotes on
T9728 19905-19910 NN denotes IRF-4
T9729 19911-19919 NN denotes promoter
T9730 19920-19928 NN denotes activity
T9731 19929-19931 PRP denotes we
T9732 19932-19941 VB denotes performed
T9733 19942-19950 NN denotes reporter
T9734 19951-19955 NN denotes gene
T9735 19956-19962 NN denotes assays
T9736 19963-19967 IN denotes with
T9737 19968-19973 NN denotes IRF-4
T9738 19974-19982 NN denotes promoter
T9739 19983-19993 NN denotes constructs
T9740 19994-20000 IN denotes before
T9741 20001-20004 CC denotes and
T9742 20005-20010 IN denotes after
T9743 20011-20016 PRP-DOLLAR- denotes their
T9744 20017-20019 FW denotes in
T9745 20020-20025 FW denotes vitro
T9746 20026-20037 NN denotes methylation
T9747 20039-20040 DT denotes A
T9748 20041-20049 JJ denotes complete
T9749 20050-20061 NN denotes methylation
T9750 20062-20064 IN denotes of
T9751 20065-20070 DT denotes these
T9752 20071-20081 NN denotes constructs
T9753 20082-20085 VB denotes was
T9754 20086-20093 VB denotes checked
T9755 20094-20097 IN denotes via
T9756 20098-20109 NN denotes restriction
T9757 20110-20116 NN denotes assays
T9758 20117-20121 IN denotes with
T9759 20122-20143 JJ denotes methylation-sensitive
T9760 20144-20157 NN denotes endonucleases
T9761 20158-20159 -LRB- denotes (
T9762 20159-20165 NN denotes Figure
T9763 20166-20168 NN denotes 5A
T9764 20168-20169 -RRB- denotes )
T9765 20171-20183 RB denotes Intriguingly
T9766 20183-20184 -COMMA- denotes ,
T9767 20185-20196 NN denotes methylation
T9768 20197-20199 IN denotes of
T9769 20200-20203 DT denotes the
T9770 20204-20209 NN denotes IRF-4
T9771 20210-20218 NN denotes promoter
T9772 20219-20232 RB denotes significantly
T9773 20233-20242 VB denotes decreased
T9774 20243-20251 NN denotes promoter
T9775 20252-20260 NN denotes activity
T9776 20261-20263 IN denotes in
T9777 20264-20278 JJ denotes IRF-4-positive
T9778 20279-20283 NN denotes SD-1
T9779 20284-20289 NN denotes cells
T9780 20290-20292 IN denotes by
T9781 20293-20297 CD denotes 85.0
T9782 20297-20298 NN denotes %
T9783 20299-20300 -LRB- denotes (
T9784 20300-20306 NN denotes Figure
T9785 20307-20309 NN denotes 5B
T9786 20309-20310 -RRB- denotes )
T9787 20312-20315 DT denotes The
T9788 20316-20325 JJ denotes silencing
T9789 20326-20332 NN denotes effect
T9790 20333-20335 IN denotes of
T9791 20336-20339 NN denotes CpG
T9792 20340-20351 NN denotes methylation
T9793 20352-20355 VB denotes was
T9794 20356-20359 RB denotes not
T9795 20360-20370 JJ denotes restricted
T9796 20371-20373 TO denotes to
T9797 20374-20388 JJ denotes IRF-4-positive
T9798 20389-20394 NN denotes cells
T9799 20394-20395 -COMMA- denotes ,
T9800 20396-20401 IN denotes since
T9801 20402-20404 FW denotes in
T9802 20405-20410 FW denotes vitro
T9803 20411-20422 NN denotes methylation
T9804 20423-20426 VB denotes led
T9805 20427-20429 TO denotes to
T9806 20430-20431 DT denotes a
T9807 20432-20436 CD denotes 92.9
T9808 20436-20437 NN denotes %
T9809 20438-20448 NN denotes abrogation
T9810 20449-20451 IN denotes of
T9811 20452-20460 NN denotes promoter
T9812 20461-20469 NN denotes activity
T9813 20470-20472 IN denotes in
T9814 20473-20487 JJ denotes IRF-4-negative
T9815 20488-20494 NN denotes Jurkat
T9816 20495-20500 NN denotes cells
T9817 20501-20502 -LRB- denotes (
T9818 20502-20508 NN denotes Figure
T9819 20509-20511 NN denotes 5C
T9820 20511-20512 -RRB- denotes )
T9821 20514-20516 IN denotes In
T9822 20517-20525 NN denotes contrast
T9823 20525-20526 -COMMA- denotes ,
T9824 20527-20534 NN denotes control
T9825 20535-20546 NN denotes methylation
T9826 20547-20549 IN denotes of
T9827 20550-20551 DT denotes a
T9828 20552-20560 NN denotes reporter
T9829 20561-20570 NN denotes construct
T9830 20571-20575 IN denotes with
T9831 20576-20577 DT denotes a
T9832 20578-20587 JJ denotes different
T9833 20588-20596 NN denotes promoter
T9834 20597-20598 -LRB- denotes (
T9835 20598-20602 NN denotes FasL
T9836 20602-20603 -RRB- denotes )
T9837 20604-20606 RB denotes as
T9838 20607-20611 RB denotes well
T9839 20612-20614 IN denotes as
T9840 20615-20617 DT denotes an
T9841 20618-20623 JJ denotes empty
T9842 20624-20630 NN denotes vector
T9843 20631-20634 VB denotes had
T9844 20635-20637 DT denotes no
T9845 20638-20644 NN denotes effect
T9846 20645-20647 IN denotes on
T9847 20648-20651 DT denotes the
T9848 20652-20660 NN denotes reporter
T9849 20661-20669 NN denotes activity
T9850 20670-20671 -LRB- denotes (
T9851 20671-20675 NN denotes data
T9852 20676-20679 RB denotes not
T9853 20680-20685 VB denotes shown
T9854 20685-20686 -RRB- denotes )
T9855 20688-20693 DT denotes These
T9856 20694-20698 NN denotes data
T9857 20699-20705 VB denotes proved
T9858 20706-20707 DT denotes a
T9859 20708-20714 JJ denotes direct
T9860 20715-20726 NN denotes association
T9861 20727-20734 IN denotes between
T9862 20735-20746 NN denotes methylation
T9863 20747-20750 CC denotes and
T9864 20751-20759 NN denotes activity
T9865 20760-20762 IN denotes of
T9866 20763-20766 DT denotes the
T9867 20767-20772 NN denotes IRF-4
T9868 20773-20781 NN denotes promoter
T10256 20784-20788 NN denotes mRNA
T10257 20789-20799 NN denotes expression
T10258 20800-20802 IN denotes of
T10259 20803-20806 NN denotes DNA
T10260 20807-20825 NN denotes methyltransferases
T10261 20826-20829 CC denotes and
T10262 20830-20848 NN denotes methyl-CpG-binding
T10263 20849-20857 NN denotes proteins
T10264 20858-20861 MD denotes may
T10265 20862-20865 RB denotes not
T10266 20866-20868 VB denotes be
T10267 20869-20879 VB denotes associated
T10268 20880-20884 IN denotes with
T10269 20885-20890 NN denotes IRF-4
T10270 20891-20899 NN denotes promoter
T10271 20900-20911 NN denotes methylation
T10272 20912-20917 IN denotes Since
T10273 20918-20927 NN denotes abundance
T10274 20928-20930 IN denotes of
T10275 20931-20935 NN denotes DNMT
T10276 20936-20939 CC denotes and
T10277 20940-20943 NN denotes MBP
T10278 20944-20954 VB denotes contribute
T10279 20955-20957 TO denotes to
T10280 20958-20966 NN denotes promoter
T10281 20967-20977 NN denotes regulation
T10282 20978-20981 IN denotes via
T10283 20982-20993 NN denotes methylation
T10284 20994-20995 -LRB- denotes (
T10285 20995-21003 CD denotes 25,26,28
T10286 21003-21004 -RRB- denotes )
T10287 21004-21005 -COMMA- denotes ,
T10288 21006-21008 PRP denotes we
T10289 21009-21016 VB denotes studied
T10290 21017-21022 PRP-DOLLAR- denotes their
T10291 21023-21027 NN denotes mRNA
T10292 21028-21038 NN denotes expression
T10293 21039-21041 TO denotes to
T10294 21042-21053 VB denotes investigate
T10295 21054-21055 DT denotes a
T10296 21056-21064 JJ denotes possible
T10297 21065-21074 NN denotes mechanism
T10298 21075-21078 IN denotes for
T10299 21079-21082 DT denotes the
T10300 21083-21091 VB denotes observed
T10301 21092-21103 NN denotes methylation
T10302 21104-21115 NN denotes differences
T10303 21116-21118 IN denotes in
T10304 21119-21122 DT denotes the
T10305 21123-21128 NN denotes IRF-4
T10306 21129-21137 NN denotes promoter
T10307 21139-21141 TO denotes To
T10308 21142-21146 DT denotes this
T10309 21147-21150 NN denotes end
T10310 21150-21151 -COMMA- denotes ,
T10311 21152-21154 PRP denotes we
T10312 21155-21158 VB denotes did
T10313 21159-21162 RB denotes not
T10314 21163-21169 VB denotes detect
T10315 21170-21171 DT denotes a
T10316 21172-21183 JJ denotes significant
T10317 21184-21194 NN denotes difference
T10318 21195-21197 IN denotes in
T10319 21198-21202 NN denotes DNMT
T10320 21203-21204 -LRB- denotes (
T10321 21204-21209 NN denotes DNMT1
T10322 21209-21210 -COMMA- denotes ,
T10323 21211-21217 NN denotes DNMT3A
T10324 21218-21221 CC denotes and
T10325 21222-21228 NN denotes DNMT3B
T10326 21228-21229 -RRB- denotes )
T10327 21230-21232 CC denotes or
T10328 21233-21236 NN denotes MBP
T10329 21237-21238 -LRB- denotes (
T10330 21238-21242 NN denotes MBD1
T10331 21242-21243 -COMMA- denotes ,
T10332 21244-21248 NN denotes MBD2
T10333 21248-21249 -COMMA- denotes ,
T10334 21250-21254 NN denotes MBD4
T10335 21255-21258 CC denotes and
T10336 21259-21263 NN denotes MeCP
T10337 21263-21264 -RRB- denotes )
T10338 21265-21269 NN denotes mRNA
T10339 21270-21280 NN denotes expression
T10340 21281-21288 IN denotes between
T10341 21289-21303 JJ denotes IRF-4-positive
T10342 21304-21307 CC denotes and
T10343 21308-21317 JJ denotes -negative
T10344 21318-21323 NN denotes cells
T10345 21324-21325 -LRB- denotes (
T10346 21325-21331 NN denotes Figure
T10347 21332-21334 NN denotes 5D
T10348 21334-21335 -RRB- denotes )
T10349 21337-21339 IN denotes In
T10350 21340-21344 NN denotes fact
T10351 21344-21345 -COMMA- denotes ,
T10352 21346-21349 DT denotes all
T10353 21350-21358 VB denotes analyzed
T10354 21359-21364 NN denotes cells
T10355 21365-21368 VB denotes had
T10356 21369-21377 JJ denotes moderate
T10357 21378-21380 TO denotes to
T10358 21381-21385 JJ denotes high
T10359 21386-21390 NN denotes mRNA
T10360 21391-21397 NN denotes levels
T10361 21398-21400 IN denotes of
T10362 21401-21406 DT denotes these
T10363 21407-21413 VB denotes tested
T10364 21414-21423 NN denotes DNMT/MBPs
T10365 21424-21427 CC denotes and
T10366 21428-21439 NN denotes differences
T10367 21440-21442 IN denotes in
T10368 21443-21453 NN denotes expression
T10369 21454-21458 VB denotes were
T10370 21459-21462 RB denotes not
T10371 21463-21473 VB denotes correlated
T10372 21474-21478 IN denotes with
T10373 21479-21484 NN denotes IRF-4
T10374 21485-21491 NN denotes status
T10375 21493-21498 DT denotes These
T10376 21499-21506 NN denotes results
T10377 21507-21515 VB denotes indicate
T10378 21516-21517 DT denotes a
T10379 21518-21526 JJ denotes distinct
T10380 21527-21532 NN denotes cause
T10381 21533-21535 IN denotes of
T10382 21536-21539 DT denotes the
T10383 21540-21551 NN denotes methylation
T10384 21552-21563 NN denotes differences
T10385 21564-21566 IN denotes in
T10386 21567-21581 JJ denotes IRF-4-positive
T10387 21582-21585 CC denotes and
T10388 21586-21595 JJ denotes -negative
T10389 21596-21601 NN denotes cells
T10390 21602-21608 RB denotes rather
T10391 21609-21613 IN denotes than
T10392 21614-21621 NN denotes changes
T10393 21622-21624 IN denotes in
T10394 21625-21628 DT denotes the
T10395 21629-21633 NN denotes DNMT
T10396 21634-21637 CC denotes and
T10397 21638-21641 NN denotes MBP
T10398 21642-21646 NN denotes mRNA
T10399 21647-21660 NN denotes transcription
T11346 21674-21678 JJ denotes Many
T11347 21679-21686 JJ denotes genetic
T11348 21687-21694 NN denotes lesions
T11349 21695-21698 VB denotes are
T11350 21699-21704 VB denotes known
T11351 21705-21707 TO denotes to
T11352 21708-21717 VB denotes influence
T11353 21718-21722 NN denotes gene
T11354 21723-21733 NN denotes expression
T11355 21734-21736 IN denotes of
T11356 21737-21742 NN denotes tumor
T11357 21743-21753 NN denotes suppressor
T11358 21754-21759 NN denotes genes
T11359 21761-21768 IN denotes Whereas
T11360 21769-21778 NN denotes mutations
T11361 21779-21782 CC denotes and
T11362 21783-21792 NN denotes deletions
T11363 21793-21795 CC denotes or
T11364 21796-21806 NN denotes insertions
T11365 21807-21811 VB denotes have
T11366 21812-21821 JJ denotes permanent
T11367 21822-21829 NN denotes effects
T11368 21829-21830 -COMMA- denotes ,
T11369 21831-21841 JJ denotes reversible
T11370 21842-21852 NN denotes mechanisms
T11371 21853-21856 VB denotes are
T11372 21857-21861 NN denotes gene
T11373 21862-21873 NN denotes methylation
T11374 21873-21874 -COMMA- denotes ,
T11375 21875-21877 CC denotes or
T11376 21878-21888 NN denotes expression
T11377 21889-21892 CC denotes and
T11378 21893-21903 NN denotes activation
T11379 21904-21906 IN denotes of
T11380 21907-21920 NN denotes transcription
T11381 21921-21928 NN denotes factors
T11382 21928-21929 -COMMA- denotes ,
T11383 21930-21942 RB denotes respectively
T11384 21944-21946 PRP denotes We
T11385 21947-21954 VB denotes studied
T11386 21955-21956 DT denotes a
T11387 21957-21965 JJ denotes putative
T11388 21966-21971 NN denotes cause
T11389 21972-21975 IN denotes for
T11390 21976-21982 JJ denotes absent
T11391 21983-21988 NN denotes IRF-4
T11392 21989-21999 NN denotes expression
T11393 22000-22002 IN denotes in
T11394 22003-22011 NN denotes leukemia
T11395 22012-22017 NN denotes cells
T11396 22018-22021 CC denotes and
T11397 22022-22027 RB denotes first
T11398 22028-22035 VB denotes focused
T11399 22036-22038 IN denotes on
T11400 22039-22046 JJ denotes genetic
T11401 22047-22058 NN denotes aberrations
T11402 22059-22061 IN denotes of
T11403 22062-22065 DT denotes the
T11404 22066-22074 NN denotes promoter
T11405 22076-22078 PRP denotes We
T11406 22079-22087 VB denotes observed
T11407 22088-22090 DT denotes no
T11408 22091-22098 JJ denotes genetic
T11409 22099-22110 NN denotes alterations
T11410 22111-22113 IN denotes in
T11411 22114-22117 DT denotes the
T11412 22118-22123 NN denotes IRF-4
T11413 22124-22132 NN denotes promoter
T11414 22132-22133 -COMMA- denotes ,
T11415 22134-22139 WDT denotes which
T11416 22140-22143 MD denotes can
T11417 22144-22151 VB denotes account
T11418 22152-22155 IN denotes for
T11419 22156-22159 DT denotes the
T11420 22160-22164 NN denotes lack
T11421 22165-22167 IN denotes of
T11422 22168-22173 NN denotes IRF-4
T11423 22174-22184 NN denotes expression
T11424 22184-22185 -COLON- denotes :
T11425 22186-22189 DT denotes The
T11426 22190-22198 VB denotes detected
T11427 22199-22203 NN denotes base
T11428 22204-22208 NN denotes pair
T11429 22209-22216 NN denotes changes
T11430 22217-22219 IN denotes at
T11431 22220-22228 NN denotes position
T11432 22229-22234 NN denotes −1081
T11433 22235-22236 -LRB- denotes (
T11434 22236-22239 NN denotes T→C
T11435 22240-22252 NN denotes substitution
T11436 22252-22253 -RRB- denotes )
T11437 22253-22254 -COMMA- denotes ,
T11438 22255-22257 IN denotes at
T11439 22258-22266 NN denotes position
T11440 22267-22272 CD denotes −1068
T11441 22273-22274 -LRB- denotes (
T11442 22274-22277 NN denotes A→C
T11443 22278-22290 NN denotes substitution
T11444 22290-22291 -RRB- denotes )
T11445 22292-22295 CC denotes and
T11446 22296-22298 IN denotes at
T11447 22299-22307 NN denotes position
T11448 22308-22312 CD denotes −116
T11449 22313-22314 -LRB- denotes (
T11450 22314-22317 NN denotes A→C
T11451 22318-22330 NN denotes substitution
T11452 22330-22331 -RRB- denotes )
T11453 22332-22335 VB denotes are
T11454 22336-22344 JJ denotes unlikely
T11455 22345-22356 JJ denotes responsible
T11456 22357-22360 IN denotes for
T11457 22361-22367 JJ denotes absent
T11458 22368-22384 NN denotes IRF-4-expression
T11459 22385-22390 IN denotes since
T11460 22391-22394 DT denotes the
T11461 22395-22400 JJ denotes first
T11462 22401-22404 CD denotes two
T11463 22405-22414 NN denotes mutations
T11464 22415-22419 VB denotes were
T11465 22420-22425 VB denotes found
T11466 22426-22430 CC denotes both
T11467 22431-22433 IN denotes in
T11468 22434-22448 JJ denotes IRF-4-positive
T11469 22449-22452 CC denotes and
T11470 22453-22462 JJ denotes -negative
T11471 22463-22468 NN denotes cells
T11472 22469-22476 IN denotes whereas
T11473 22477-22480 DT denotes the
T11474 22481-22487 JJ denotes latter
T11475 22488-22494 NN denotes change
T11476 22495-22498 VB denotes was
T11477 22499-22502 RB denotes not
T11478 22503-22511 VB denotes detected
T11479 22512-22524 RB denotes consistently
T11480 22525-22527 IN denotes in
T11481 22528-22531 DT denotes all
T11482 22532-22546 JJ denotes IRF-4-negative
T11483 22547-22549 CC denotes or
T11484 22550-22559 JJ denotes -positive
T11485 22560-22565 NN denotes cells
T11486 22566-22569 CC denotes and
T11487 22570-22573 MD denotes may
T11488 22574-22578 RB denotes thus
T11489 22579-22581 VB denotes be
T11490 22582-22583 DT denotes a
T11491 22584-22596 NN denotes polymorphism
T11492 22598-22601 DT denotes All
T11493 22602-22607 CD denotes three
T11494 22608-22621 NN denotes substitutions
T11495 22622-22625 VB denotes did
T11496 22626-22629 RB denotes not
T11497 22630-22636 VB denotes change
T11498 22637-22640 DT denotes any
T11499 22641-22646 JJ denotes known
T11500 22647-22655 JJ denotes putative
T11501 22656-22669 NN denotes transcription
T11502 22670-22676 NN denotes factor
T11503 22677-22684 NN denotes binding
T11504 22685-22690 NN denotes sites
T11505 22691-22692 -LRB- denotes (
T11506 22692-22697 CD denotes 30,31
T11507 22697-22698 -RRB- denotes )
T11508 22699-22702 CC denotes and
T11509 22703-22707 RB denotes also
T11510 22708-22710 VB denotes do
T11511 22711-22714 RB denotes not
T11512 22715-22721 VB denotes affect
T11513 22722-22725 DT denotes any
T11514 22726-22737 NN denotes restriction
T11515 22738-22743 NN denotes sites
T11516 22744-22746 CC denotes or
T11517 22747-22753 NN denotes primer
T11518 22754-22761 NN denotes binding
T11519 22762-22767 NN denotes sites
T11520 22768-22770 IN denotes of
T11521 22771-22774 DT denotes the
T11522 22775-22779 VB denotes used
T11523 22780-22786 NN denotes assays
T11524 22788-22795 RB denotes However
T11525 22795-22796 -COMMA- denotes ,
T11526 22797-22806 JJ denotes permanent
T11527 22807-22814 JJ denotes genetic
T11528 22815-22825 NN denotes variations
T11529 22826-22828 IN denotes in
T11530 22829-22832 DT denotes the
T11531 22833-22838 NN denotes IRF-4
T11532 22839-22845 NN denotes coding
T11533 22846-22854 NN denotes sequence
T11534 22854-22855 -COMMA- denotes ,
T11535 22856-22860 JJ denotes such
T11536 22861-22863 IN denotes as
T11537 22864-22873 NN denotes deletions
T11538 22874-22876 CC denotes or
T11539 22877-22886 NN denotes mutations
T11540 22887-22896 VB denotes resulting
T11541 22897-22899 IN denotes in
T11542 22900-22911 NN denotes stop-codons
T11543 22912-22916 VB denotes have
T11544 22917-22920 RB denotes not
T11545 22921-22925 VB denotes been
T11546 22926-22934 VB denotes excluded
T11547 22935-22937 IN denotes by
T11548 22938-22946 NN denotes sequence
T11549 22947-22955 NN denotes analysis
T11550 22957-22962 IN denotes Since
T11551 22963-22968 NN denotes IRF-4
T11552 22969-22979 NN denotes expression
T11553 22980-22982 IN denotes in
T11554 22983-22987 NN denotes cell
T11555 22988-22993 NN denotes lines
T11556 22994-22997 CC denotes and
T11557 22998-23001 NN denotes CML
T11558 23002-23005 MD denotes can
T11559 23006-23008 VB denotes be
T11560 23009-23016 VB denotes induced
T11561 23017-23019 IN denotes by
T11562 23020-23033 NN denotes demethylation
T11563 23034-23037 CC denotes and
T11564 23038-23048 JJ denotes successful
T11565 23049-23054 NN denotes IFN-α
T11566 23055-23062 NN denotes therapy
T11567 23063-23064 -LRB- denotes (
T11568 23064-23065 CD denotes 3
T11569 23065-23066 -RRB- denotes )
T11570 23066-23067 -COMMA- denotes ,
T11571 23068-23080 RB denotes respectively
T11572 23080-23081 -COMMA- denotes ,
T11573 23082-23085 DT denotes the
T11574 23086-23095 NN denotes existence
T11575 23096-23098 IN denotes of
T11576 23099-23103 JJ denotes such
T11577 23104-23111 JJ denotes genetic
T11578 23112-23123 NN denotes aberrations
T11579 23124-23129 VB denotes seems
T11580 23130-23138 JJ denotes unlikely
T11581 23140-23142 PRP denotes We
T11582 23143-23147 RB denotes then
T11583 23148-23160 VB denotes investigated
T11584 23161-23168 IN denotes whether
T11585 23169-23172 DT denotes the
T11586 23173-23183 RB denotes previously
T11587 23184-23193 VB denotes described
T11588 23194-23209 NN denotes down-regulation
T11589 23210-23212 IN denotes of
T11590 23213-23218 NN denotes IRF-4
T11591 23219-23229 NN denotes expression
T11592 23230-23232 IN denotes in
T11593 23233-23238 JJ denotes human
T11594 23239-23246 JJ denotes myeloid
T11595 23247-23256 NN denotes leukemias
T11596 23257-23260 VB denotes was
T11597 23261-23264 JJ denotes due
T11598 23265-23267 TO denotes to
T11599 23268-23269 DT denotes a
T11600 23270-23282 JJ denotes differential
T11601 23283-23299 NN denotes hypermethylation
T11602 23300-23302 IN denotes of
T11603 23303-23306 DT denotes the
T11604 23307-23315 NN denotes promoter
T11605 23315-23316 -COMMA- denotes ,
T11606 23317-23322 IN denotes since
T11607 23323-23326 DT denotes the
T11608 23327-23336 VB denotes presented
T11609 23337-23350 NN denotes re-expression
T11610 23351-23354 IN denotes due
T11611 23355-23357 TO denotes to
T11612 23358-23373 NN denotes AzadC-treatment
T11613 23374-23379 MD denotes might
T11614 23380-23384 RB denotes also
T11615 23385-23387 VB denotes be
T11616 23388-23389 DT denotes a
T11617 23390-23396 NN denotes result
T11618 23397-23399 IN denotes of
T11619 23400-23410 NN denotes activation
T11620 23411-23413 IN denotes of
T11621 23414-23422 JJ denotes positive
T11622 23423-23438 JJ denotes transcriptional
T11623 23439-23449 NN denotes regulators
T11624 23450-23452 IN denotes of
T11625 23453-23458 NN denotes IRF-4
T11626 23460-23471 NN denotes Methylation
T11627 23472-23474 IN denotes of
T11628 23475-23478 NN denotes CpG
T11629 23479-23484 NN denotes sites
T11630 23485-23487 VB denotes is
T11631 23488-23489 DT denotes a
T11632 23490-23496 JJ denotes common
T11633 23497-23506 NN denotes mechanism
T11634 23507-23509 IN denotes of
T11635 23510-23519 NN denotes silencing
T11636 23520-23525 NN denotes genes
T11637 23526-23528 IN denotes in
T11638 23529-23537 NN denotes leukemia
T11639 23538-23541 CC denotes and
T11640 23542-23545 VB denotes has
T11641 23546-23550 RB denotes also
T11642 23551-23555 VB denotes been
T11643 23556-23561 VB denotes shown
T11644 23562-23565 IN denotes for
T11645 23566-23573 DT denotes another
T11646 23574-23577 NN denotes IRF
T11647 23577-23578 -COMMA- denotes ,
T11648 23579-23584 NN denotes IRF-7
T11649 23585-23586 -LRB- denotes (
T11650 23586-23588 CD denotes 35
T11651 23588-23589 -RRB- denotes )
T11652 23590-23593 CC denotes and
T11653 23594-23597 IN denotes for
T11654 23598-23602 NN denotes PU.1
T11655 23603-23604 -LRB- denotes (
T11656 23604-23606 CD denotes 36
T11657 23606-23607 -RRB- denotes )
T11658 23607-23608 -COMMA- denotes ,
T11659 23609-23611 DT denotes an
T11660 23612-23623 VB denotes interacting
T11661 23624-23631 NN denotes partner
T11662 23632-23634 IN denotes of
T11663 23635-23640 NN denotes IRF-4
T11664 23642-23644 TO denotes To
T11665 23645-23654 VB denotes elucidate
T11666 23655-23658 DT denotes the
T11667 23659-23668 NN denotes relevance
T11668 23669-23671 IN denotes of
T11669 23672-23676 DT denotes this
T11670 23677-23686 NN denotes mechanism
T11671 23687-23690 IN denotes for
T11672 23691-23694 DT denotes the
T11673 23695-23705 NN denotes regulation
T11674 23706-23708 IN denotes of
T11675 23709-23714 NN denotes IRF-4
T11676 23715-23725 NN denotes expression
T11677 23725-23726 -COMMA- denotes ,
T11678 23727-23734 JJ denotes various
T11679 23735-23743 JJ denotes leukemic
T11680 23744-23749 NN denotes cells
T11681 23750-23754 VB denotes were
T11682 23755-23762 VB denotes treated
T11683 23763-23767 IN denotes with
T11684 23768-23781 VB denotes demethylating
T11685 23782-23788 NN denotes agents
T11686 23789-23792 CC denotes and
T11687 23793-23802 NN denotes promoters
T11688 23803-23807 VB denotes were
T11689 23808-23817 VB denotes sequenced
T11690 23818-23823 IN denotes after
T11691 23824-23833 NN denotes bisulfite
T11692 23834-23843 NN denotes treatment
T11693 23845-23847 PRP denotes We
T11694 23848-23853 VB denotes found
T11695 23854-23858 IN denotes that
T11696 23859-23864 NN denotes IRF-4
T11697 23865-23875 NN denotes expression
T11698 23876-23881 MD denotes could
T11699 23882-23888 RB denotes indeed
T11700 23889-23891 VB denotes be
T11701 23892-23901 VB denotes connected
T11702 23902-23904 TO denotes to
T11703 23905-23908 DT denotes the
T11704 23909-23920 NN denotes methylation
T11705 23921-23927 NN denotes status
T11706 23928-23930 IN denotes of
T11707 23931-23939 JJ denotes distinct
T11708 23940-23943 NN denotes CpG
T11709 23944-23950 NN denotes motifs
T11710 23951-23953 IN denotes in
T11711 23954-23957 DT denotes the
T11712 23958-23963 NN denotes IRF-4
T11713 23964-23972 NN denotes promoter
T11714 23974-23976 IN denotes In
T11715 23977-23983 NN denotes Figure
T11716 23984-23986 NN denotes 4A
T11717 23986-23987 -COMMA- denotes ,
T11718 23988-23993 DT denotes those
T11719 23994-23997 NN denotes CpG
T11720 23998-24003 NN denotes sites
T11721 24004-24007 VB denotes are
T11722 24008-24013 VB denotes shown
T11723 24014-24015 -LRB- denotes (
T11724 24015-24021 JJ denotes bottom
T11725 24022-24026 NN denotes line
T11726 24026-24027 -RRB- denotes )
T11727 24027-24028 -COMMA- denotes ,
T11728 24029-24034 WP-DOLLAR- denotes whose
T11729 24035-24051 NN denotes hypermethylation
T11730 24052-24055 MD denotes may
T11731 24056-24063 VB denotes account
T11732 24064-24067 IN denotes for
T11733 24068-24071 DT denotes the
T11734 24072-24079 NN denotes absence
T11735 24080-24082 IN denotes of
T11736 24083-24088 NN denotes IRF-4
T11737 24089-24099 NN denotes expression
T11738 24100-24102 IN denotes in
T11739 24103-24106 DT denotes the
T11740 24107-24117 JJ denotes respective
T11741 24118-24123 NN denotes cells
T11742 24125-24128 CD denotes One
T11743 24129-24131 IN denotes of
T11744 24132-24136 PRP denotes them
T11745 24137-24138 -LRB- denotes (
T11746 24138-24139 -SHARP- denotes #
T11747 24139-24141 CD denotes 54
T11748 24141-24142 -RRB- denotes )
T11749 24143-24145 VB denotes is
T11750 24146-24154 JJ denotes adjacent
T11751 24155-24157 TO denotes to
T11752 24158-24160 DT denotes an
T11753 24161-24171 VB denotes identified
T11754 24172-24182 JJ denotes regulatory
T11755 24183-24190 NN denotes element
T11756 24191-24192 -LRB- denotes (
T11757 24192-24201 NN denotes NFκB-site
T11758 24201-24202 -RRB- denotes )
T11759 24202-24203 -COMMA- denotes ,
T11760 24204-24214 VB denotes indicating
T11761 24215-24216 DT denotes a
T11762 24217-24225 JJ denotes possible
T11763 24226-24237 NN denotes involvement
T11764 24238-24240 IN denotes of
T11765 24241-24245 DT denotes this
T11766 24246-24250 NN denotes site
T11767 24252-24254 IN denotes At
T11768 24255-24258 CD denotes two
T11769 24259-24266 JJ denotes further
T11770 24267-24270 NN denotes CpG
T11771 24271-24276 NN denotes sites
T11772 24277-24278 -LRB- denotes (
T11773 24278-24279 -SHARP- denotes #
T11774 24279-24281 CD denotes 48
T11775 24281-24282 -COMMA- denotes ,
T11776 24283-24285 CD denotes 45
T11777 24285-24286 -RRB- denotes )
T11778 24287-24290 DT denotes the
T11779 24291-24302 NN denotes methylation
T11780 24303-24309 NN denotes status
T11781 24310-24312 IN denotes in
T11782 24313-24327 JJ denotes IRF-4-positive
T11783 24328-24331 VB denotes was
T11784 24332-24337 JJ denotes lower
T11785 24338-24342 IN denotes than
T11786 24343-24347 DT denotes that
T11787 24348-24350 IN denotes of
T11788 24351-24365 JJ denotes IRF-4-negative
T11789 24366-24371 NN denotes cells
T11790 24373-24378 DT denotes These
T11791 24379-24382 NN denotes CpG
T11792 24383-24388 NN denotes sites
T11793 24389-24392 VB denotes are
T11794 24393-24400 JJ denotes located
T11795 24401-24403 IN denotes in
T11796 24404-24406 DT denotes an
T11797 24407-24411 NN denotes NFκB
T11798 24412-24415 CC denotes and
T11799 24416-24418 DT denotes an
T11800 24419-24422 NN denotes SP1
T11801 24423-24430 NN denotes element
T11802 24431-24432 -LRB- denotes (
T11803 24432-24434 CD denotes 31
T11804 24434-24435 -RRB- denotes )
T11805 24436-24439 CC denotes and
T11806 24440-24444 RB denotes thus
T11807 24445-24448 MD denotes may
T11808 24449-24453 RB denotes also
T11809 24454-24458 VB denotes play
T11810 24459-24460 DT denotes a
T11811 24461-24465 NN denotes role
T11812 24466-24468 IN denotes in
T11813 24469-24479 NN denotes regulation
T11814 24480-24482 IN denotes of
T11815 24483-24488 NN denotes IRF-4
T11816 24489-24499 NN denotes expression
T11817 24501-24503 PRP denotes It
T11818 24504-24507 VB denotes has
T11819 24508-24512 VB denotes been
T11820 24513-24518 VB denotes shown
T11821 24519-24523 IN denotes that
T11822 24524-24528 NN denotes NFκB
T11823 24529-24537 NN denotes elements
T11824 24538-24542 VB denotes play
T11825 24543-24545 DT denotes an
T11826 24546-24555 JJ denotes important
T11827 24556-24560 NN denotes role
T11828 24561-24563 IN denotes in
T11829 24564-24569 NN denotes IRF-4
T11830 24570-24579 NN denotes induction
T11831 24580-24582 IN denotes as
T11832 24583-24588 NN denotes IRF-4
T11833 24589-24599 NN denotes expression
T11834 24600-24607 VB denotes depends
T11835 24608-24610 IN denotes on
T11836 24611-24618 NN denotes binding
T11837 24619-24621 IN denotes of
T11838 24622-24625 DT denotes the
T11839 24626-24640 NN denotes transactivator
T11840 24641-24646 NN denotes c-Rel
T11841 24647-24649 TO denotes to
T11842 24650-24655 DT denotes these
T11843 24656-24664 NN denotes elements
T11844 24665-24667 IN denotes in
T11845 24668-24671 DT denotes the
T11846 24672-24677 NN denotes IRF-4
T11847 24678-24686 NN denotes promoter
T11848 24687-24688 -LRB- denotes (
T11849 24688-24693 CD denotes 31,37
T11850 24693-24694 -RRB- denotes )
T11851 24696-24707 RB denotes Furthermore
T11852 24707-24708 -COMMA- denotes ,
T11853 24709-24720 NN denotes methylation
T11854 24721-24723 IN denotes of
T11855 24724-24727 DT denotes the
T11856 24728-24735 JJ denotes central
T11857 24736-24739 NN denotes CpG
T11858 24740-24742 IN denotes in
T11859 24743-24746 DT denotes the
T11860 24747-24751 NN denotes NFκB
T11861 24752-24759 NN denotes element
T11863 24769-24776 NN denotes binding
T11864 24777-24779 IN denotes of
T11865 24780-24783 DT denotes the
T11866 24784-24788 NN denotes NFκB
T11867 24789-24796 NN denotes protein
T11868 24797-24806 NN denotes complexes
T11869 24807-24808 -LRB- denotes (
T11870 24808-24810 CD denotes 38
T11871 24810-24811 -RRB- denotes )
T11872 24811-24812 -COMMA- denotes ,
T11873 24813-24822 VB denotes promoting
T11874 24823-24826 DT denotes the
T11875 24827-24839 NN denotes significance
T11876 24840-24842 IN denotes of
T11877 24843-24846 DT denotes the
T11878 24847-24855 VB denotes observed
T11879 24856-24867 NN denotes methylation
T11880 24868-24879 NN denotes differences
T11881 24880-24882 IN denotes in
T11882 24883-24897 JJ denotes IRF-4-positive
T11883 24898-24901 CC denotes and
T11884 24902-24911 JJ denotes -negative
T11885 24912-24917 NN denotes cells
T11886 24919-24922 NNP denotes Via
T11887 24923-24925 FW denotes in
T11888 24926-24931 FW denotes vitro
T11889 24932-24943 NN denotes methylation
T11890 24944-24947 CC denotes and
T11891 24948-24956 NN denotes reporter
T11892 24957-24961 NN denotes gene
T11893 24962-24968 NN denotes assays
T11894 24969-24971 PRP denotes we
T11895 24972-24977 MD denotes could
T11896 24978-24985 RB denotes clearly
T11897 24986-24993 VB denotes appoint
T11898 24994-24997 DT denotes the
T11899 24998-25007 NN denotes silencing
T11900 25008-25010 IN denotes of
T11901 25011-25014 DT denotes the
T11902 25015-25020 NN denotes IRF-4
T11903 25021-25029 NN denotes promoter
T11904 25030-25032 TO denotes to
T11905 25033-25034 DT denotes a
T11906 25035-25046 NN denotes methylation
T11907 25047-25053 NN denotes effect
T11908 25053-25054 -COMMA- denotes ,
T11909 25055-25060 WDT denotes which
T11910 25061-25064 MD denotes may
T11911 25065-25069 RB denotes thus
T11912 25070-25072 VB denotes be
T11913 25073-25076 DT denotes the
T11914 25077-25086 NN denotes mechanism
T11915 25087-25089 IN denotes of
T11916 25090-25095 NN denotes IRF-4
T11917 25096-25108 NN denotes deregulation
T11918 25109-25111 FW denotes in
T11919 25112-25116 FW denotes vivo
T11920 25118-25121 CD denotes One
T11921 25122-25130 JJ denotes possible
T11922 25131-25136 NN denotes cause
T11923 25137-25140 IN denotes for
T11924 25141-25144 DT denotes the
T11925 25145-25153 JJ denotes aberrant
T11926 25154-25165 NN denotes methylation
T11927 25166-25168 IN denotes in
T11928 25169-25182 NN denotes tumorigenesis
T11929 25183-25185 VB denotes is
T11930 25186-25188 DT denotes an
T11931 25189-25198 VB denotes increased
T11932 25199-25204 NN denotes level
T11933 25205-25207 IN denotes of
T11934 25208-25213 NN denotes DNMTs
T11935 25214-25220 IN denotes during
T11936 25221-25224 DT denotes the
T11937 25225-25237 JJ denotes pathogenetic
T11938 25238-25245 NN denotes process
T11939 25247-25249 IN denotes In
T11940 25250-25255 NN denotes colon
T11941 25255-25256 -COMMA- denotes ,
T11942 25257-25261 NN denotes lung
T11943 25262-25265 CC denotes and
T11944 25266-25277 JJ denotes hematologic
T11945 25278-25290 NN denotes malignancies
T11946 25290-25291 -COMMA- denotes ,
T11947 25292-25306 NN denotes overexpression
T11948 25307-25309 IN denotes of
T11949 25310-25315 NN denotes DNMT1
T11950 25315-25316 -COMMA- denotes ,
T11951 25317-25318 DT denotes a
T11952 25319-25330 NN denotes maintenance
T11953 25331-25335 NN denotes DNMT
T11954 25335-25336 -COMMA- denotes ,
T11955 25337-25340 VB denotes has
T11956 25341-25345 VB denotes been
T11957 25346-25354 VB denotes detected
T11958 25355-25356 -LRB- denotes (
T11959 25356-25361 CD denotes 39–41
T11960 25361-25362 -RRB- denotes )
T11961 25364-25375 RB denotes Furthermore
T11962 25375-25376 -COMMA- denotes ,
T11963 25377-25379 PRP denotes it
T11964 25380-25383 VB denotes has
T11965 25384-25388 VB denotes been
T11966 25389-25394 VB denotes shown
T11967 25395-25399 IN denotes that
T11968 25400-25403 NN denotes CML
T11969 25404-25409 NN denotes cells
T11970 25410-25412 IN denotes in
T11971 25413-25416 DT denotes the
T11972 25417-25422 JJ denotes acute
T11973 25423-25428 NN denotes phase
T11974 25429-25438 VB denotes exhibited
T11975 25439-25447 JJ denotes elevated
T11976 25448-25454 NN denotes levels
T11977 25455-25457 IN denotes of
T11978 25458-25461 DT denotes the
T11979 25462-25467 CD denotes three
T11980 25468-25473 VB denotes known
T11981 25474-25479 NN denotes DNMTs
T11982 25479-25480 -COMMA- denotes ,
T11983 25481-25486 IN denotes while
T11984 25487-25490 NN denotes CML
T11985 25491-25496 NN denotes cells
T11986 25497-25499 IN denotes in
T11987 25500-25507 JJ denotes chronic
T11988 25508-25513 NN denotes phase
T11989 25514-25523 VB denotes expressed
T11990 25524-25530 JJ denotes normal
T11991 25531-25537 NN denotes levels
T11992 25538-25540 IN denotes of
T11993 25541-25546 NN denotes DNMTs
T11994 25547-25549 IN denotes if
T11995 25550-25558 VB denotes compared
T11996 25559-25563 IN denotes with
T11997 25564-25570 JJ denotes normal
T11998 25571-25575 NN denotes bone
T11999 25576-25582 NN denotes marrow
T12000 25583-25588 NN denotes cells
T12001 25589-25590 -LRB- denotes (
T12002 25590-25592 CD denotes 25
T12003 25592-25593 -RRB- denotes )
T12004 25595-25608 RB denotes Interestingly
T12005 25608-25609 -COMMA- denotes ,
T12006 25610-25611 DT denotes a
T12007 25612-25620 JJ denotes positive
T12008 25621-25632 NN denotes correlation
T12009 25633-25640 IN denotes between
T12010 25641-25646 NN denotes DNMT1
T12011 25647-25657 NN denotes expression
T12012 25658-25664 NN denotes levels
T12013 25665-25668 CC denotes and
T12014 25669-25685 NN denotes hypermethylation
T12015 25686-25688 IN denotes of
T12016 25689-25697 NN denotes p15INK4b
T12017 25698-25701 VB denotes has
T12018 25702-25706 VB denotes been
T12019 25707-25715 VB denotes detected
T12020 25716-25718 IN denotes in
T12021 25719-25722 NN denotes AML
T12022 25723-25724 -LRB- denotes (
T12023 25724-25726 CD denotes 25
T12024 25726-25727 -RRB- denotes )
T12025 25729-25731 IN denotes In
T12026 25732-25736 DT denotes this
T12027 25737-25741 NN denotes work
T12028 25741-25742 -COMMA- denotes ,
T12029 25743-25745 PRP denotes we
T12030 25746-25749 VB denotes did
T12031 25750-25753 RB denotes not
T12032 25754-25760 VB denotes detect
T12033 25761-25772 JJ denotes significant
T12034 25773-25777 NN denotes mRNA
T12035 25778-25788 NN denotes expression
T12036 25789-25800 NN denotes differences
T12037 25801-25803 IN denotes of
T12038 25804-25812 VB denotes selected
T12039 25813-25817 NN denotes DNMT
T12040 25818-25820 CC denotes or
T12041 25821-25824 NN denotes MBP
T12042 25824-25825 -COMMA- denotes ,
T12043 25826-25832 VB denotes making
T12044 25833-25835 PRP denotes it
T12045 25836-25838 DT denotes an
T12046 25839-25847 JJ denotes unlikely
T12047 25848-25853 NN denotes cause
T12048 25854-25857 IN denotes for
T12049 25858-25861 DT denotes the
T12050 25862-25870 VB denotes observed
T12051 25871-25882 NN denotes methylation
T12052 25883-25886 CC denotes and
T12053 25887-25891 RB denotes thus
T12054 25892-25897 NN denotes IRF-4
T12055 25898-25908 NN denotes expression
T12056 25909-25920 NN denotes differences
T12057 25921-25923 IN denotes in
T12058 25924-25932 NN denotes leukemia
T12059 25933-25938 NN denotes cells
T12060 25940-25943 DT denotes The
T12061 25944-25951 NN denotes finding
T12062 25952-25956 IN denotes that
T12063 25957-25962 NN denotes IRF-4
T12064 25963-25973 NN denotes expression
T12065 25974-25976 VB denotes is
T12066 25977-25985 VB denotes silenced
T12067 25986-25988 IN denotes by
T12068 25989-25997 NN denotes promoter
T12069 25998-26014 NN denotes hypermethylation
T12070 26015-26020 MD denotes might
T12071 26021-26030 VB denotes represent
T12072 26031-26032 DT denotes a
T12073 26033-26042 NN denotes mechanism
T12074 26043-26047 WDT denotes that
T12075 26048-26056 VB denotes accounts
T12076 26057-26060 IN denotes for
T12077 26061-26064 DT denotes the
T12078 26065-26075 RB denotes previously
T12079 26076-26084 VB denotes observed
T12080 26085-26089 NN denotes loss
T12081 26090-26092 IN denotes of
T12082 26093-26098 NN denotes IRF-4
T12083 26099-26109 NN denotes expression
T12084 26110-26112 IN denotes in
T12085 26113-26116 NN denotes CML
T12086 26118-26124 RB denotes Indeed
T12087 26124-26125 -COMMA- denotes ,
T12088 26126-26133 JJ denotes several
T12089 26134-26142 JJ denotes clinical
T12090 26143-26149 NN denotes trials
T12091 26150-26154 IN denotes with
T12092 26155-26163 NN denotes leukemia
T12093 26164-26172 NN denotes patients
T12094 26173-26176 CC denotes and
T12095 26177-26185 NN denotes patients
T12096 26186-26190 IN denotes with
T12097 26191-26206 JJ denotes myelodysplastic
T12098 26207-26216 NN denotes syndromes
T12099 26217-26229 VB denotes demonstrated
T12100 26230-26233 DT denotes the
T12101 26234-26243 JJ denotes potential
T12102 26244-26252 JJ denotes clinical
T12103 26253-26260 NN denotes benefit
T12104 26261-26263 IN denotes of
T12105 26264-26265 DT denotes a
T12106 26266-26275 NN denotes treatment
T12107 26276-26280 IN denotes with
T12108 26281-26294 VB denotes demethylating
T12109 26295-26301 NN denotes agents
T12110 26302-26303 -LRB- denotes (
T12111 26303-26308 CD denotes 42–45
T12112 26308-26309 -RRB- denotes )
T12113 26311-26314 DT denotes The
T12114 26315-26325 NN denotes expression
T12115 26326-26328 IN denotes of
T12116 26329-26336 DT denotes another
T12117 26337-26340 NN denotes IRF
T12118 26340-26341 -COMMA- denotes ,
T12119 26342-26345 NN denotes IFN
T12120 26346-26355 NN denotes consensus
T12121 26356-26364 NN denotes sequence
T12122 26365-26372 NN denotes binding
T12123 26373-26380 NN denotes protein
T12124 26381-26382 -LRB- denotes (
T12125 26382-26393 NN denotes ICSBP/IRF-8
T12126 26393-26394 -RRB- denotes )
T12127 26394-26395 -COMMA- denotes ,
T12128 26396-26398 VB denotes is
T12129 26399-26407 JJ denotes impaired
T12130 26408-26410 IN denotes in
T12131 26411-26418 JJ denotes myeloid
T12132 26419-26428 NN denotes leukemias
T12133 26429-26439 RB denotes especially
T12134 26440-26443 NN denotes CML
T12135 26444-26445 -LRB- denotes (
T12136 26445-26453 CD denotes 27,46,47
T12137 26453-26454 -RRB- denotes )
T12138 26456-26459 CC denotes But
T12139 26460-26462 IN denotes in
T12140 26463-26471 NN denotes contrast
T12141 26472-26474 TO denotes to
T12142 26475-26480 NN denotes IRF-4
T12143 26480-26481 -COMMA- denotes ,
T12144 26482-26485 DT denotes the
T12145 26486-26490 NN denotes loss
T12146 26491-26493 IN denotes of
T12147 26494-26498 DT denotes this
T12148 26499-26502 NN denotes IRF
T12149 26503-26508 MD denotes could
T12150 26509-26512 RB denotes not
T12151 26513-26515 VB denotes be
T12152 26516-26524 VB denotes reverted
T12153 26525-26527 IN denotes in
T12154 26528-26542 JJ denotes ICSBP-negative
T12155 26543-26547 NN denotes cell
T12156 26548-26553 NN denotes lines
T12157 26554-26555 -LRB- denotes (
T12158 26555-26559 NN denotes EM-2
T12159 26559-26560 -COMMA- denotes ,
T12160 26561-26567 NN denotes CML-T1
T12161 26567-26568 -COMMA- denotes ,
T12162 26569-26574 NN denotes K-562
T12163 26575-26578 CC denotes and
T12164 26579-26586 NN denotes LAMA-84
T12165 26586-26587 -RRB- denotes )
T12166 26588-26590 IN denotes by
T12167 26591-26600 NN denotes treatment
T12168 26601-26605 IN denotes with
T12169 26606-26611 NN denotes AzadC
T12170 26612-26613 -LRB- denotes (
T12171 26613-26619 NN denotes Figure
T12172 26620-26621 CD denotes 6
T12173 26621-26622 -RRB- denotes )
T12174 26623-26626 CC denotes and
T12175 26627-26632 NN denotes AzadC
T12176 26633-26636 VB denotes has
T12177 26637-26639 DT denotes no
T12178 26640-26646 NN denotes effect
T12179 26647-26649 IN denotes on
T12180 26650-26655 NN denotes ICSBP
T12181 26656-26662 NN denotes levels
T12182 26663-26665 IN denotes in
T12183 26666-26680 JJ denotes ICSBP-positive
T12184 26681-26686 NN denotes U-937
T12185 26687-26692 NN denotes cells
T12186 26693-26694 -LRB- denotes (
T12187 26694-26700 NN denotes Figure
T12188 26701-26702 CD denotes 6
T12189 26702-26703 -RRB- denotes )
T12190 26705-26710 DT denotes These
T12191 26711-26715 NN denotes data
T12192 26716-26723 VB denotes suggest
T12193 26724-26725 DT denotes a
T12194 26726-26734 JJ denotes distinct
T12195 26735-26745 JJ denotes regulatory
T12196 26746-26755 NN denotes mechanism
T12197 26756-26759 IN denotes for
T12198 26760-26765 DT denotes these
T12199 26766-26769 CD denotes two
T12200 26770-26774 NN denotes IRFs
T12201 26776-26781 NN denotes IRF-4
T12202 26781-26782 -COMMA- denotes ,
T12203 26783-26790 JJ denotes similar
T12204 26791-26793 TO denotes to
T12205 26794-26798 JJ denotes many
T12206 26799-26804 JJ denotes other
T12207 26805-26814 JJ denotes classical
T12208 26815-26820 NN denotes tumor
T12209 26821-26831 NN denotes suppressor
T12210 26832-26837 NN denotes genes
T12211 26838-26846 NN denotes p15INK4b
T12212 26846-26847 -COMMA- denotes ,
T12213 26848-26856 NN denotes p16INK4a
T12214 26857-26859 CC denotes or
T12215 26860-26863 NN denotes p53
T12216 26863-26864 -COMMA- denotes ,
T12217 26865-26868 MD denotes may
T12218 26869-26873 RB denotes thus
T12219 26874-26876 VB denotes be
T12220 26877-26878 DT denotes a
T12221 26879-26886 NN denotes subject
T12222 26887-26889 IN denotes of
T12223 26890-26901 NN denotes alterations
T12224 26902-26904 IN denotes in
T12225 26905-26908 DT denotes the
T12226 26909-26917 NN denotes promoter
T12227 26918-26929 NN denotes methylation
T12228 26930-26936 NN denotes status
T12229 26937-26944 VB denotes leading
T12230 26945-26947 TO denotes to
T12231 26948-26958 NN denotes expression
T12232 26959-26966 NN denotes changes
T12233 26966-26967 -COMMA- denotes ,
T12234 26968-26973 WDT denotes which
T12235 26974-26979 MD denotes might
T12236 26980-26990 VB denotes contribute
T12237 26991-26993 TO denotes to
T12238 26994-26997 DT denotes the
T12239 26998-27008 NN denotes initiation
T12240 27009-27015 CC denotes and/or
T12241 27016-27027 NN denotes progression
T12242 27028-27030 IN denotes of
T12243 27031-27037 NN denotes cancer
T12244 27039-27044 RB denotes Still
T12245 27044-27045 -COMMA- denotes ,
T12246 27046-27049 DT denotes the
T12247 27050-27057 JJ denotes obvious
T12248 27058-27068 JJ denotes functional
T12249 27069-27078 NN denotes diversity
T12250 27079-27081 IN denotes of
T12251 27082-27087 NN denotes IRF-4
T12252 27088-27095 VB denotes remains
T12253 27096-27106 JJ denotes remarkable
T12254 27107-27110 CC denotes and
T12255 27111-27114 MD denotes can
T12256 27114-27117 RB denotes not
T12257 27118-27120 VB denotes be
T12258 27121-27126 RB denotes fully
T12259 27127-27136 VB denotes explained
T12260 27137-27139 IN denotes by
T12261 27140-27143 DT denotes the
T12262 27144-27149 NN denotes IRF-4
T12263 27150-27158 NN denotes promoter
T12264 27159-27170 NN denotes methylation
T12265 27171-27177 NN denotes status
T12266 27179-27182 IN denotes For
T12267 27183-27190 NN denotes example
T12268 27190-27191 -COMMA- denotes ,
T12269 27192-27197 NN denotes IRF-4
T12270 27198-27200 VB denotes is
T12271 27201-27210 RB denotes primarily
T12272 27211-27216 VB denotes known
T12273 27217-27220 IN denotes for
T12274 27221-27224 PRP-DOLLAR- denotes its
T12275 27225-27234 JJ denotes oncogenic
T12276 27235-27243 NN denotes features
T12277 27245-27247 IN denotes In
T12278 27248-27256 JJ denotes multiple
T12279 27257-27264 NN denotes myeloma
T12280 27265-27266 -LRB- denotes (
T12281 27266-27268 NN denotes MM
T12282 27268-27269 -RRB- denotes )
T12283 27270-27271 DT denotes a
T12284 27272-27285 NN denotes translocation
T12285 27286-27288 IN denotes on
T12286 27289-27299 NN denotes chromosome
T12287 27300-27303 NN denotes 14q
T12288 27304-27307 VB denotes was
T12289 27308-27316 VB denotes reported
T12290 27317-27319 TO denotes to
T12291 27320-27324 VB denotes lead
T12292 27325-27327 TO denotes to
T12293 27328-27329 DT denotes a
T12294 27330-27336 NN denotes fusion
T12295 27337-27341 NN denotes gene
T12296 27342-27344 IN denotes of
T12297 27345-27359 NN denotes immunoglobulin
T12298 27360-27371 NN denotes heavy-chain
T12299 27372-27373 -LRB- denotes (
T12300 27373-27376 NN denotes IgH
T12301 27376-27377 -RRB- denotes )
T12302 27378-27381 CC denotes and
T12303 27382-27387 NN denotes IRF-4
T12304 27388-27397 VB denotes resulting
T12305 27398-27400 IN denotes in
T12306 27401-27402 DT denotes a
T12307 27403-27413 JJ denotes subsequent
T12308 27414-27428 NN denotes overexpression
T12309 27429-27431 IN denotes of
T12310 27432-27437 NN denotes IRF-4
T12311 27438-27439 -LRB- denotes (
T12312 27439-27444 CD denotes 48,49
T12313 27444-27445 -RRB- denotes )
T12314 27447-27449 IN denotes In
T12315 27450-27458 NN denotes addition
T12316 27458-27459 -COMMA- denotes ,
T12317 27460-27468 JJ denotes abundant
T12318 27469-27474 NN denotes IRF-4
T12319 27475-27485 NN denotes expression
T12320 27486-27489 VB denotes was
T12321 27490-27495 VB denotes found
T12322 27496-27498 TO denotes to
T12323 27499-27501 VB denotes be
T12324 27502-27503 DT denotes a
T12325 27504-27510 NN denotes marker
T12326 27511-27514 IN denotes for
T12327 27515-27522 JJ denotes various
T12328 27523-27530 NN denotes subsets
T12329 27531-27533 IN denotes of
T12330 27534-27543 NN denotes lymphomas
T12331 27543-27544 -COMMA- denotes ,
T12332 27545-27549 JJ denotes such
T12333 27550-27552 IN denotes as
T12334 27553-27560 JJ denotes diffuse
T12335 27561-27566 JJ denotes large
T12336 27567-27573 NN denotes B-cell
T12337 27574-27583 NN denotes lymphomas
T12338 27583-27584 -COMMA- denotes ,
T12339 27585-27592 JJ denotes primary
T12340 27593-27601 NN denotes effusion
T12341 27602-27610 NN denotes lymphoma
T12342 27610-27611 -COMMA- denotes ,
T12343 27612-27615 CC denotes and
T12344 27616-27624 JJ denotes marginal
T12345 27625-27629 NN denotes zone
T12346 27630-27638 NN denotes lymphoma
T12347 27638-27639 -COMMA- denotes ,
T12348 27640-27643 CC denotes and
T12349 27644-27649 JJ denotes adult
T12350 27650-27656 NN denotes T-cell
T12351 27657-27665 NN denotes leukemia
T12352 27666-27667 -LRB- denotes (
T12353 27667-27678 CD denotes 11,31,50–52
T12354 27678-27679 -RRB- denotes )
T12355 27681-27685 DT denotes This
T12356 27686-27691 VB denotes draws
T12357 27692-27693 DT denotes a
T12358 27694-27698 RB denotes more
T12359 27699-27706 JJ denotes complex
T12360 27707-27714 NN denotes picture
T12361 27715-27717 IN denotes of
T12362 27718-27721 DT denotes the
T12363 27722-27726 NN denotes role
T12364 27727-27729 IN denotes of
T12365 27730-27735 NN denotes IRF-4
T12366 27737-27752 NN denotes Down-regulation
T12367 27753-27755 IN denotes of
T12368 27756-27761 NN denotes IRF-4
T12369 27762-27765 MD denotes may
T12370 27766-27773 VB denotes promote
T12371 27774-27788 NN denotes leukemogenesis
T12372 27789-27791 IN denotes in
T12373 27792-27799 JJ denotes myeloid
T12374 27800-27804 NN denotes cell
T12375 27805-27812 NN denotes context
T12376 27813-27814 -LRB- denotes (
T12377 27814-27815 CD denotes 3
T12378 27815-27816 -RRB- denotes )
T12379 27816-27817 -COMMA- denotes ,
T12380 27818-27823 WDT denotes which
T12381 27824-27827 VB denotes was
T12382 27828-27836 RB denotes recently
T12383 27837-27846 VB denotes confirmed
T12384 27847-27849 IN denotes in
T12385 27850-27858 NN denotes IRF-4−/−
T12386 27859-27867 NN denotes ICSBP−/−
T12387 27868-27874 JJ denotes double
T12388 27875-27884 JJ denotes knock-out
T12389 27885-27889 NN denotes mice
T12390 27890-27891 -LRB- denotes (
T12391 27891-27893 CD denotes 53
T12392 27893-27894 -RRB- denotes )
T12393 27894-27895 -COMMA- denotes ,
T12394 27896-27901 IN denotes while
T12395 27902-27907 NN denotes IRF-4
T12396 27908-27921 NN denotes up-regulation
T12397 27922-27925 MD denotes may
T12398 27926-27932 VB denotes induce
T12399 27933-27934 DT denotes a
T12400 27935-27941 NN denotes growth
T12401 27942-27951 NN denotes advantage
T12402 27952-27954 IN denotes in
T12403 27955-27964 NN denotes lymphomas
T12404 27965-27967 CC denotes or
T12405 27968-27970 NN denotes MM
T12406 27971-27972 -LRB- denotes (
T12407 27972-27974 CD denotes 48
T12408 27974-27975 -RRB- denotes )
T12409 27977-27982 VB denotes Taken
T12410 27983-27991 RB denotes together
T12411 27991-27992 -COMMA- denotes ,
T12412 27993-27996 PRP-DOLLAR- denotes our
T12413 27997-28001 NN denotes data
T12414 28002-28009 VB denotes suggest
T12415 28010-28014 IN denotes that
T12416 28015-28020 NN denotes IRF-4
T12417 28021-28029 NN denotes promoter
T12418 28030-28041 NN denotes methylation
T12419 28042-28051 VB denotes regulates
T12420 28052-28057 NN denotes IRF-4
T12421 28058-28068 NN denotes expression
T12422 28068-28069 -COMMA- denotes ,
T12423 28070-28073 CC denotes and
T12424 28074-28078 IN denotes that
T12425 28079-28087 JJ denotes aberrant
T12426 28088-28098 NN denotes expression
T12427 28099-28101 IN denotes of
T12428 28102-28107 NN denotes IRF-4
T12429 28108-28110 IN denotes in
T12430 28111-28118 JJ denotes certain
T12431 28119-28124 NN denotes types
T12432 28125-28127 IN denotes of
T12433 28128-28136 NN denotes leukemia
T12434 28137-28140 MD denotes may
T12435 28141-28143 VB denotes be
T12436 28144-28145 DT denotes a
T12437 28146-28157 NN denotes consequence
T12438 28158-28160 IN denotes of
T12439 28161-28166 NN denotes IRF-4
T12440 28167-28175 NN denotes promoter
T12441 28176-28192 NN denotes hypermethylation
T3062 5973-5983 NN denotes Sequencing
T3063 5984-5986 IN denotes of
T3064 5987-5990 DT denotes the
T3065 5991-5996 NN denotes IRF-4
T3066 5997-6005 NN denotes promoter
T3067 6006-6009 IN denotes For
T3068 6010-6018 NN denotes analysis
T3069 6019-6021 IN denotes of
T3070 6022-6025 DT denotes the
T3071 6026-6031 NN denotes IRF-4
T3072 6032-6040 NN denotes promoter
T3073 6041-6047 NN denotes region
T3074 6048-6051 IN denotes for
T3075 6052-6061 JJ denotes permanent
R41 T129 T130 arg1Of Down-regulation,of
R79 T166 T165 arg1Of leukemia,myeloid
R80 T166 T167 arg1Of leukemia,(
R81 T168 T167 arg2Of CML,(
R82 T169 T167 arg3Of ),(
R83 T171 T172 arg1Of there,is
R84 T172 T150 arg1Of is,Although
R85 T172 T170 arg1Of is,","
R86 T174 T172 arg2Of evidence,is
R87 T174 T173 arg1Of evidence,mounting
R88 T177 T176 arg1Of deregulation,the
R89 T177 T178 arg1Of deregulation,of
R90 T177 T195 arg1Of deregulation,is
R91 T177 T197 arg2Of deregulation,implicated
R92 T180 T178 arg2Of genes,of
R93 T180 T179 arg1Of genes,other
R94 T180 T181 arg1Of genes,","
R95 T180 T183 arg1Of genes,as
R96 T183 T182 arg1Of as,such
R97 T189 T183 arg2Of factor,as
R98 T189 T184 arg1Of factor,the
R99 T189 T185 arg1Of factor,transcription
R100 T189 T186 arg1Of factor,factor
R101 T189 T187 arg1Of factor,interferon
R102 T189 T188 arg1Of factor,regulatory
R114 T200 T199 arg1Of pathogenesis,the
R115 T200 T201 arg1Of pathogenesis,of
R116 T202 T201 arg2Of CML,of
R117 T204 T203 arg1Of methylation,Promoter
R118 T204 T205 arg1Of methylation,of
R119 T204 T214 arg1Of methylation,are
R120 T208 T206 arg1Of sites,CpG
R121 T208 T207 arg1Of sites,target
R122 T208 T209 arg1Of sites,or
R123 T209 T205 arg2Of or,of
R124 T211 T209 arg2Of deletions/insertions,or
R125 T211 T210 arg1Of deletions/insertions,direct
R126 T211 T212 arg1Of deletions/insertions,of
R127 T213 T212 arg2Of genes,of
R128 T214 T225 arg1Of are,","
R129 T214 T226 arg1Of are,respectively
R177 T260 T261 arg1Of cause,of
R178 T264 T261 arg2Of expression,of
R179 T264 T262 arg2Of expression,altered
R180 T264 T263 arg1Of expression,IRF-4
R181 T264 T265 arg1Of expression,in
R182 T267 T265 arg2Of cells,in
R183 T267 T266 arg1Of cells,hematopoietic
R184 T273 T269 arg1Of status,the
R185 T273 T270 arg1Of status,IRF-4
R186 T273 T271 arg1Of status,promoter
R187 T273 T272 arg1Of status,methylation
R188 T273 T274 arg1Of status,was
R42 T129 T137 arg1Of Down-regulation,in
R43 T136 T130 arg2Of expression,of
R44 T136 T131 arg1Of expression,interferon
R45 T136 T132 arg1Of expression,regulatory
R46 T136 T133 arg1Of expression,factor
R47 T136 T134 arg1Of expression,4
R48 T136 T135 arg1Of expression,gene
R49 T139 T137 arg2Of cells,in
R50 T139 T138 arg1Of cells,leukemic
R51 T139 T140 arg1Of cells,due
R52 T140 T141 arg1Of due,to
R53 T142 T141 arg2Of hypermethylation,to
R54 T142 T143 arg1Of hypermethylation,of
R55 T145 T143 arg2Of motifs,of
R56 T145 T144 arg1Of motifs,CpG
R57 T145 T146 arg1Of motifs,in
R58 T149 T146 arg2Of region,in
R59 T149 T147 arg1Of region,the
R60 T149 T148 arg1Of region,promoter
R61 T153 T151 arg1Of translocation,the
R62 T153 T152 arg1Of translocation,bcr-abl
R63 T153 T154 arg1Of translocation,has
R64 T153 T155 arg1Of translocation,been
R65 T153 T156 arg2Of translocation,shown
R66 T153 T158 arg1Of translocation,be
R67 T156 T150 arg2Of shown,Although
R68 T156 T154 arg2Of shown,has
R69 T156 T155 arg2Of shown,been
R70 T158 T156 arg3Of be,shown
R71 T158 T157 arg1Of be,to
R72 T158 T163 arg1Of be,in
R73 T162 T158 arg2Of aberration,be
R74 T162 T159 arg1Of aberration,the
R75 T162 T160 arg1Of aberration,causative
R76 T162 T161 arg1Of aberration,genetic
R77 T166 T163 arg2Of leukemia,in
R78 T166 T164 arg1Of leukemia,chronic
R103 T189 T190 arg1Of factor,4
R104 T189 T191 arg1Of factor,(
R105 T192 T191 arg2Of IRF-4,(
R106 T193 T191 arg3Of ),(
R107 T197 T174 arg2Of implicated,evidence
R108 T197 T175 arg1Of implicated,that
R109 T197 T194 arg1Of implicated,","
R110 T197 T195 arg2Of implicated,is
R111 T197 T196 arg1Of implicated,also
R112 T197 T198 arg1Of implicated,in
R113 T200 T198 arg2Of pathogenesis,in
R130 T215 T214 arg2Of mechanisms,are
R131 T215 T216 arg1Of mechanisms,of
R132 T218 T219 arg1Of reversible,or
R133 T220 T219 arg2Of permanent,or
R134 T221 T216 arg2Of silencing,of
R135 T221 T217 arg1Of silencing,a
R136 T221 T218 arg1Of silencing,reversible
R137 T221 T220 arg1Of silencing,permanent
R138 T221 T222 arg1Of silencing,of
R139 T224 T222 arg2Of expression,of
R140 T224 T223 arg1Of expression,gene
R141 T229 T230 arg1Of we,investigated
R142 T230 T227 arg1Of investigated,Therefore
R143 T230 T228 arg1Of investigated,","
R144 T234 T232 arg1Of methylation,IRF-4
R145 T234 T233 arg1Of methylation,promoter
R146 T234 T235 arg1Of methylation,or
R147 T235 T237 arg1Of or,may
R148 T235 T238 arg1Of or,be
R149 T235 T239 arg2Of or,involved
R150 T236 T235 arg2Of mutation,or
R151 T239 T230 arg2Of involved,investigated
R152 T239 T231 arg1Of involved,whether
R153 T239 T237 arg2Of involved,may
R154 T239 T238 arg2Of involved,be
R155 T239 T240 arg1Of involved,in
R156 T242 T240 arg2Of regulation,in
R157 T242 T241 arg1Of regulation,the
R158 T242 T243 arg1Of regulation,of
R159 T245 T243 arg2Of expression,of
R160 T245 T244 arg1Of expression,IRF-4
R161 T245 T246 arg1Of expression,in
R162 T248 T246 arg2Of cells,in
R163 T248 T247 arg1Of cells,leukemia
R164 T251 T250 arg1Of mutations,promoter
R165 T251 T252 arg1Of mutations,or
R166 T252 T255 arg1Of or,could
R167 T252 T256 arg1Of or,be
R168 T252 T257 arg2Of or,excluded
R169 T254 T252 arg2Of rearrangements,or
R170 T254 T253 arg1Of rearrangements,structural
R171 T257 T249 arg2Of excluded,Whereas
R172 T257 T255 arg2Of excluded,could
R173 T257 T256 arg2Of excluded,be
R174 T257 T258 arg1Of excluded,as
R175 T260 T258 arg2Of cause,as
R176 T260 T259 arg1Of cause,a
R189 T273 T275 arg2Of status,found
R190 T273 T278 arg1Of status,influence
R191 T275 T249 arg1Of found,Whereas
R192 T275 T268 arg1Of found,","
R193 T275 T274 arg2Of found,was
R194 T278 T275 arg3Of influence,found
R195 T278 T276 arg1Of influence,to
R196 T278 T277 arg1Of influence,significantly
R197 T280 T278 arg2Of transcription,influence
R198 T280 T279 arg1Of transcription,IRF-4
R199 T283 T284 arg1Of treatment,of
R200 T283 T297 arg1Of treatment,resulted
R201 T286 T287 arg1Of lymphoid,","
R202 T287 T289 arg1Of ",",and
R203 T288 T287 arg2Of myeloid,","
R204 T290 T289 arg2Of monocytic,and
R205 T292 T284 arg2Of lines,of
R206 T292 T285 arg1Of lines,IRF-4-negative
R207 T292 T286 arg1Of lines,lymphoid
R208 T292 T288 arg1Of lines,myeloid
R209 T292 T290 arg1Of lines,monocytic
R210 T292 T291 arg1Of lines,cell
R211 T292 T293 arg1Of lines,with
R212 T296 T293 arg2Of 5-aza-2-deoxycytidine,with
R213 T296 T294 arg1Of 5-aza-2-deoxycytidine,the
R214 T296 T295 arg1Of 5-aza-2-deoxycytidine,methylation-inhibitor
R215 T297 T281 arg1Of resulted,First
R216 T297 T282 arg1Of resulted,","
R217 T297 T298 arg1Of resulted,in
R218 T300 T301 arg1Of time-,and
R219 T302 T301 arg2Of concentration-dependent,and
R220 T303 T298 arg2Of increase,in
R221 T303 T299 arg1Of increase,a
R222 T303 T300 arg1Of increase,time-
R223 T303 T302 arg1Of increase,concentration-dependent
R224 T303 T304 arg1Of increase,of
R225 T306 T307 arg1Of mRNA,and
R226 T308 T307 arg2Of protein,and
R227 T309 T304 arg2Of levels,of
R228 T309 T305 arg1Of levels,IRF-4
R229 T309 T306 arg1Of levels,mRNA
R230 T309 T308 arg1Of levels,protein
R231 T314 T315 arg1Of restriction-PCR-assay,and
R232 T315 T312 arg2Of and,using
R233 T315 T313 arg1Of and,a
R234 T316 T315 arg2Of bisulfite-sequencing,and
R235 T317 T312 arg1Of we,using
R236 T317 T318 arg1Of we,identified
R237 T318 T310 arg1Of identified,Second
R238 T318 T311 arg1Of identified,","
R239 T318 T312 modOf identified,using
R240 T318 T323 arg1Of identified,in
R241 T318 T327 arg1Of identified,in
R242 T320 T319 arg1Of methylated,specifically
R243 T322 T318 arg2Of sites,identified
R244 T322 T320 arg1Of sites,methylated
R245 T322 T321 arg1Of sites,CpG
R246 T323 T325 arg1Of in,but
R247 T324 T323 arg2Of IRF-4-negative,in
R248 T327 T325 arg2Of in,but
R249 T327 T326 arg1Of in,not
R250 T329 T327 arg2Of cells,in
R251 T329 T328 arg1Of cells,IRF-4-positive
R252 T332 T334 arg1Of we,determined
R253 T332 T349 arg1Of we,did
R254 T332 T351 arg1Of we,detect
R255 T334 T337 arg1Of determined,as
R256 T334 T348 arg1Of determined,but
R257 T336 T334 arg2Of methylation,determined
R258 T336 T335 arg1Of methylation,promoter
R259 T339 T337 arg2Of mechanism,as
R260 T339 T338 arg1Of mechanism,a
R261 T339 T340 arg1Of mechanism,for
R262 T339 T343 arg1Of mechanism,via
R263 T342 T340 arg2Of down-regulation,for
R264 T342 T341 arg1Of down-regulation,IRF-4
R265 T346 T343 arg2Of assays,via
R266 T346 T344 arg1Of assays,reporter
R267 T346 T345 arg1Of assays,gene
R268 T348 T330 arg1Of but,Third
R269 T348 T331 arg1Of but,","
R270 T348 T333 arg1Of but,clearly
R271 T348 T347 arg1Of but,","
R272 T351 T348 arg2Of detect,but
R273 T351 T349 arg2Of detect,did
R274 T351 T350 arg1Of detect,not
R275 T353 T351 arg2Of association,detect
R276 T353 T352 arg1Of association,an
R277 T353 T354 arg1Of association,of
R278 T356 T357 arg1Of status,and
R279 T358 T357 arg2Of mRNA,and
R280 T359 T354 arg2Of expression,of
R281 T359 T355 arg1Of expression,methylational
R282 T359 T356 arg1Of expression,status
R283 T359 T358 arg1Of expression,mRNA
R284 T359 T360 arg1Of expression,of
R285 T362 T361 arg1Of methyltransferases,DNA
R286 T362 T363 arg1Of methyltransferases,or
R287 T363 T360 arg2Of or,of
R288 T365 T363 arg2Of proteins,or
R289 T365 T364 arg1Of proteins,methyl-CpG-binding
R290 T369 T368 arg1Of data,these
R291 T369 T370 arg1Of data,suggest
R292 T370 T366 arg1Of suggest,Together
R293 T370 T367 arg1Of suggest,","
R294 T370 T376 arg1Of suggest,as
R295 T375 T370 arg2Of methylation,suggest
R296 T375 T371 arg1Of methylation,CpG
R297 T375 T372 arg1Of methylation,site-specific
R298 T375 T373 arg1Of methylation,IRF-4
R299 T375 T374 arg1Of methylation,promoter
R300 T379 T376 arg2Of mechanism,as
R301 T379 T377 arg1Of mechanism,a
R302 T379 T378 arg1Of mechanism,putative
R303 T379 T380 arg1Of mechanism,of
R304 T379 T384 arg1Of mechanism,in
R305 T383 T380 arg2Of expression,of
R306 T383 T381 arg2Of expression,down-regulated
R307 T383 T382 arg1Of expression,IRF-4
R308 T385 T384 arg2Of leukemia,in
R772 T1106 T1104 arg1Of leukemia,Chronic
R773 T1106 T1105 arg1Of leukemia,myeloid
R774 T1106 T1107 arg1Of leukemia,(
R775 T1106 T1110 arg1Of leukemia,is
R776 T1108 T1107 arg2Of CML,(
R777 T1109 T1107 arg3Of ),(
R778 T1114 T1110 arg2Of disorder,is
R779 T1114 T1111 arg1Of disorder,a
R780 T1114 T1112 arg1Of disorder,clonal
R781 T1114 T1113 arg1Of disorder,myeloproliferative
R782 T1114 T1115 arg1Of disorder,with
R783 T1120 T1115 arg2Of course,with
R784 T1120 T1116 arg1Of course,a
R785 T1120 T1117 arg1Of course,typical
R786 T1120 T1118 arg1Of course,three
R787 T1120 T1119 arg1Of course,phased
R788 T1120 T1121 arg1Of course,(
R789 T1120 T1129 arg1Of course,reflecting
R790 T1122 T1123 arg1Of chronic,","
R791 T1123 T1125 arg1Of ",",and
R792 T1124 T1123 arg2Of accelerated,","
R793 T1126 T1125 arg2Of blastic,and
R794 T1127 T1121 arg2Of phase,(
R795 T1127 T1122 arg1Of phase,chronic
R796 T1127 T1124 arg1Of phase,accelerated
R797 T1127 T1126 arg1Of phase,blastic
R798 T1128 T1121 arg3Of ),(
R799 T1131 T1129 arg2Of loss,reflecting
R800 T1131 T1130 arg1Of loss,the
R801 T1131 T1132 arg1Of loss,of
R802 T1131 T1137 arg1Of loss,which
R803 T1131 T1139 arg1Of loss,leads
R804 T1133 T1134 arg1Of differentiation,and
R805 T1134 T1132 arg2Of and,of
R806 T1136 T1134 arg2Of progress,and
R807 T1136 T1135 arg1Of progress,malignant
R808 T1139 T1138 arg1Of leads,inevitably
R809 T1139 T1140 arg1Of leads,to
R810 T1139 T1142 arg1Of leads,after
R811 T1141 T1140 arg2Of death,to
R812 T1145 T1142 arg2Of phase,after
R813 T1145 T1143 arg1Of phase,the
R814 T1145 T1144 arg1Of phase,blastic
R815 T1145 T1146 arg1Of phase,(
R816 T1147 T1146 arg2Of "1,2",(
R817 T1148 T1146 arg3Of ),(
R818 T1152 T1149 arg1Of aberration,The
R819 T1152 T1150 arg1Of aberration,hallmark
R820 T1152 T1151 arg1Of aberration,genetic
R821 T1152 T1153 arg1Of aberration,of
R822 T1152 T1155 arg1Of aberration,is
R823 T1154 T1153 arg2Of CML,of
R824 T1160 T1155 arg2Of t,is
R825 T1160 T1156 arg1Of t,a
R826 T1160 T1157 arg1Of t,reciprocal
R827 T1160 T1158 arg1Of t,chromosomal
R828 T1160 T1159 arg1Of t,translocation
R829 T1160 T1161 arg1Of t,(
R830 T1160 T1166 arg1Of t,leading
R831 T1162 T1163 arg1Of 9,;
R832 T1163 T1161 arg2Of ;,(
R833 T1164 T1163 arg2Of 22,;
R834 T1165 T1161 arg3Of ),(
R835 T1166 T1167 arg1Of leading,to
R836 T1168 T1167 arg2Of expression,to
R837 T1168 T1169 arg1Of expression,of
R838 T1173 T1169 arg2Of gene,of
R839 T1173 T1170 arg1Of gene,a
R840 T1173 T1171 arg1Of gene,bcr-abl
R841 T1173 T1172 arg1Of gene,fusion
R842 T1173 T1174 arg1Of gene,","
R843 T1179 T1174 arg2Of kinase,","
R844 T1179 T1175 arg1Of kinase,an
R845 T1179 T1176 arg1Of kinase,aberrant
R846 T1179 T1177 arg2Of kinase,activated
R847 T1179 T1178 arg1Of kinase,tyrosine
R848 T1179 T1180 arg1Of kinase,(
R849 T1181 T1180 arg2Of 2,(
R850 T1182 T1180 arg3Of ),(
R851 T1183 T1184 arg1Of Treatment,with
R852 T1183 T1190 arg1Of Treatment,prolongs
R853 T1183 T1196 arg1Of Treatment,is
R854 T1183 T1197 arg2Of Treatment,associated
R855 T1186 T1184 arg2Of α,with
R856 T1186 T1185 arg1Of α,interferon
R857 T1186 T1187 arg1Of α,(
R858 T1188 T1187 arg2Of IFN-α,(
R859 T1189 T1187 arg3Of ),(
R860 T1190 T1195 arg1Of prolongs,and
R861 T1191 T1190 arg2Of survival,prolongs
R862 T1191 T1192 arg1Of survival,of
R863 T1194 T1192 arg2Of patients,of
R864 T1194 T1193 arg1Of patients,CML
R865 T1197 T1195 arg2Of associated,and
R866 T1197 T1196 arg2Of associated,is
R867 T1197 T1198 arg1Of associated,with
R868 T1202 T1198 arg2Of response,with
R869 T1202 T1199 arg1Of response,a
R870 T1202 T1200 arg1Of response,complete
R871 T1202 T1201 arg1Of response,cytogenetic
R872 T1202 T1203 arg1Of response,in
R873 T1205 T1203 arg2Of %,in
R874 T1205 T1204 arg1Of %,5–33
R875 T1205 T1206 arg1Of %,of
R876 T1208 T1206 arg2Of patients,of
R877 T1208 T1207 arg1Of patients,CML
R878 T1208 T1209 arg1Of patients,(
R879 T1210 T1209 arg2Of "1,2",(
R880 T1211 T1209 arg3Of ),(
R881 T1214 T1215 arg1Of we,described
R882 T1215 T1212 arg1Of described,Recently
R883 T1215 T1213 arg1Of described,","
R884 T1215 T1228 arg1Of described,in
R885 T1215 T1230 arg1Of described,","
R886 T1215 T1231 modOf described,correlating
R887 T1218 T1215 arg2Of expression,described
R888 T1218 T1216 arg1Of expression,an
R889 T1218 T1217 arg1Of expression,impaired
R890 T1218 T1219 arg1Of expression,of
R891 T1223 T1219 arg2Of factor,of
R892 T1223 T1220 arg1Of factor,the
R893 T1223 T1221 arg1Of factor,interferon
R894 T1223 T1222 arg1Of factor,regulatory
R895 T1223 T1224 arg1Of factor,4
R896 T1223 T1225 arg1Of factor,(
R897 T1226 T1225 arg2Of IRF-4,(
R898 T1227 T1225 arg3Of ),(
R899 T1229 T1228 arg2Of CML,in
R900 T1231 T1232 arg1Of correlating,with
R901 T1234 T1232 arg2Of response,with
R902 T1234 T1233 arg1Of response,poor
R903 T1234 T1235 arg1Of response,to
R904 T1237 T1235 arg2Of treatment,to
R905 T1237 T1236 arg1Of treatment,IFN-α
R906 T1237 T1238 arg1Of treatment,(
R907 T1239 T1238 arg2Of 3,(
R908 T1240 T1238 arg3Of ),(
R909 T1242 T1241 arg1Of cause,The
R910 T1242 T1243 arg1Of cause,of
R911 T1242 T1249 arg1Of cause,remained
R912 T1242 T1250 arg1Of cause,unclear
R913 T1245 T1243 arg2Of silencing,of
R914 T1245 T1244 arg1Of silencing,the
R915 T1245 T1246 arg1Of silencing,of
R916 T1248 T1246 arg2Of level,of
R917 T1248 T1247 arg1Of level,IRF-4
R918 T1250 T1249 arg2Of unclear,remained
R919 T1253 T1251 arg1Of factors,Interferon
R920 T1253 T1252 arg1Of factors,regulatory
R921 T1253 T1254 arg1Of factors,(
R922 T1253 T1257 arg1Of factors,are
R923 T1255 T1254 arg2Of IRFs,(
R924 T1256 T1254 arg3Of ),(
R925 T1259 T1257 arg2Of family,are
R926 T1259 T1258 arg1Of family,a
R927 T1259 T1260 arg1Of family,of
R928 T1262 T1260 arg2Of regulators,of
R929 T1262 T1261 arg1Of regulators,transcriptional
R930 T1262 T1263 arg2Of regulators,defined
R931 T1267 T1263 arg1Of homology,defined
R932 T1267 T1264 arg2Of homology,by
R933 T1267 T1265 arg1Of homology,a
R934 T1267 T1266 arg1Of homology,characteristic
R935 T1267 T1268 arg1Of homology,in
R936 T1271 T1268 arg2Of domain,in
R937 T1271 T1269 arg1Of domain,their
R938 T1271 T1270 arg1Of domain,DNA-binding
R939 T1272 T1273 arg1Of They,play
R940 T1273 T1277 arg1Of play,in
R941 T1276 T1273 arg2Of role,play
R942 T1276 T1274 arg1Of role,an
R943 T1276 T1275 arg1Of role,important
R944 T1279 T1280 arg1Of regulation,of
R945 T1279 T1294 arg1Of regulation,","
R946 T1282 T1280 arg2Of genes,of
R947 T1282 T1281 arg1Of genes,various
R948 T1282 T1283 arg1Of genes,(
R949 T1282 T1285 arg1Of genes,as
R950 T1285 T1284 arg1Of as,such
R951 T1286 T1287 arg1Of IFNs,","
R952 T1287 T1289 arg1Of ",",","
R953 T1288 T1287 arg2Of interleukins,","
R954 T1289 T1285 arg2Of ",",as
R955 T1292 T1289 arg2Of I/II,","
R956 T1292 T1290 arg1Of I/II,MHC
R957 T1292 T1291 arg1Of I/II,class
R958 T1292 T1293 arg1Of I/II,)
R959 T1294 T1277 arg2Of ",",in
R960 T1294 T1278 arg1Of ",",the
R961 T1295 T1296 arg1Of apoptosis,and
R962 T1296 T1294 arg2Of and,","
R963 T1296 T1298 arg1Of and,(
R964 T1297 T1296 arg2Of differentiation/maturation,and
R965 T1299 T1298 arg2Of 4–6,(
R966 T1300 T1298 arg3Of ),(
R967 T1301 T1302 arg1Of IRF-4,(
R968 T1301 T1305 arg1Of IRF-4,is
R969 T1303 T1302 arg2Of ICSAT/Pip/MUM1/LSIRF,(
R970 T1304 T1302 arg3Of ),(
R971 T1307 T1305 arg2Of member,is
R972 T1307 T1306 arg1Of member,one
R973 T1307 T1308 arg1Of member,with
R974 T1307 T1313 arg1Of member,:
R975 T1310 T1309 arg1Of restricted,very
R976 T1312 T1308 arg2Of pattern,with
R977 T1312 T1310 arg1Of pattern,restricted
R978 T1312 T1311 arg1Of pattern,expression
R979 T1315 T1314 arg1Of B-,Predominately
R980 T1315 T1316 arg1Of B-,and
R981 T1316 T1319 arg1Of and,are
R982 T1318 T1316 arg2Of T-lymphocytes,and
R983 T1318 T1317 arg2Of T-lymphocytes,activated
R984 T1320 T1319 arg2Of IRF-4,are
R985 T1320 T1321 arg1Of IRF-4,positive
R986 T1320 T1322 arg1Of IRF-4,(
R987 T1323 T1322 arg2Of 7–11,(
R988 T1324 T1322 arg3Of ),(
R989 T1326 T1325 arg2Of contrast,In
R990 T1326 T1327 arg1Of contrast,to
R991 T1329 T1327 arg2Of IRFs,to
R992 T1329 T1328 arg1Of IRFs,other
R993 T1331 T1332 arg1Of expression,of
R994 T1331 T1334 arg1Of expression,can
R995 T1331 T1336 arg1Of expression,be
R996 T1331 T1337 arg2Of expression,induced
R997 T1333 T1332 arg2Of IRF-4,of
R998 T1337 T1325 arg1Of induced,In
R999 T1337 T1330 arg1Of induced,","
R1000 T1337 T1334 arg2Of induced,can
R1001 T1337 T1335 arg1Of induced,not
R1002 T1337 T1336 arg2Of induced,be
R1003 T1337 T1341 arg1Of induced,but
R1004 T1337 T1342 arg1Of induced,by
R1005 T1339 T1337 arg1Of IFNs,induced
R1006 T1339 T1338 arg2Of IFNs,by
R1007 T1341 T1340 arg1Of but,","
R1008 T1344 T1343 arg1Of stimulation,antigen
R1009 T1344 T1345 arg1Of stimulation,","
R1010 T1345 T1352 arg1Of ",",or
R1011 T1346 T1345 arg2Of crosslinking,","
R1012 T1346 T1347 arg1Of crosslinking,of
R1013 T1348 T1349 arg1Of T-,or
R1014 T1350 T1349 arg2Of B-cell,or
R1015 T1351 T1347 arg2Of receptors,of
R1016 T1351 T1348 arg1Of receptors,T-
R1017 T1351 T1350 arg1Of receptors,B-cell
R1018 T1352 T1342 arg2Of or,by
R1019 T1353 T1352 arg2Of phorbol-myristate-acetate,or
R1020 T1353 T1354 arg1Of phorbol-myristate-acetate,(
R1021 T1355 T1354 arg2Of "10,11",(
R1022 T1356 T1354 arg3Of ),(
R1023 T1357 T1358 arg1Of Consistent,with
R1024 T1360 T1358 arg2Of restriction,with
R1025 T1360 T1359 arg1Of restriction,the
R1026 T1360 T1361 arg1Of restriction,of
R1027 T1360 T1363 arg1Of restriction,to
R1028 T1362 T1361 arg2Of expression,of
R1029 T1365 T1363 arg2Of cells,to
R1030 T1365 T1364 arg1Of cells,immunocompetent
R1031 T1367 T1368 arg1Of mice,with
R1032 T1367 T1372 arg1Of mice,failed
R1033 T1367 T1374 arg1Of mice,develop
R1034 T1369 T1368 arg2Of deletion,with
R1035 T1369 T1370 arg1Of deletion,of
R1036 T1371 T1370 arg2Of IRF-4,of
R1037 T1372 T1386 arg1Of failed,and
R1038 T1374 T1372 arg2Of develop,failed
R1039 T1374 T1373 arg1Of develop,to
R1040 T1375 T1376 arg1Of mature,and
R1041 T1378 T1376 arg2Of active,and
R1042 T1378 T1377 arg1Of active,functionally
R1043 T1379 T1375 arg1Of B-,mature
R1044 T1379 T1378 arg1Of B-,active
R1045 T1379 T1380 arg1Of B-,and
R1046 T1380 T1374 arg2Of and,develop
R1047 T1381 T1380 arg2Of T-lymphocytes,and
R1048 T1381 T1382 arg1Of T-lymphocytes,(
R1049 T1383 T1382 arg2Of 12,(
R1050 T1384 T1382 arg3Of ),(
R1051 T1386 T1357 arg1Of and,Consistent
R1052 T1386 T1366 arg1Of and,","
R1053 T1386 T1385 arg1Of and,","
R1054 T1389 T1387 arg1Of expression,the
R1055 T1389 T1388 arg1Of expression,impaired
R1056 T1389 T1390 arg1Of expression,of
R1057 T1389 T1392 arg1Of expression,in
R1058 T1389 T1394 arg1Of expression,was
R1059 T1389 T1396 arg2Of expression,found
R1060 T1391 T1390 arg2Of IRF-4,of
R1061 T1393 T1392 arg2Of CML,in
R1062 T1396 T1386 arg2Of found,and
R1063 T1396 T1394 arg2Of found,was
R1064 T1396 T1395 arg1Of found,predominately
R1065 T1396 T1397 arg1Of found,in
R1066 T1398 T1397 arg2Of T-cells,in
R1067 T1398 T1399 arg1Of T-cells,(
R1068 T1400 T1399 arg2Of 3,(
R1069 T1401 T1399 arg3Of ),(
R1070 T1403 T1402 arg1Of data,These
R1071 T1403 T1404 arg1Of data,suggest
R1072 T1407 T1404 arg2Of role,suggest
R1073 T1407 T1405 arg1Of role,a
R1074 T1407 T1406 arg1Of role,crucial
R1075 T1407 T1408 arg1Of role,for
R1076 T1407 T1410 arg1Of role,in
R1077 T1409 T1408 arg2Of IRF-4,for
R1078 T1412 T1410 arg2Of function,in
R1079 T1412 T1411 arg1Of function,the
R1080 T1412 T1413 arg1Of function,of
R1081 T1415 T1413 arg2Of cells,of
R1082 T1415 T1414 arg1Of cells,immune
R1083 T1416 T1417 arg1Of Methylation,of
R1084 T1416 T1424 arg1Of Methylation,","
R1085 T1416 T1426 arg1Of Methylation,in
R1086 T1416 T1434 arg1Of Methylation,is
R1087 T1420 T1417 arg2Of motifs,of
R1088 T1420 T1418 arg1Of motifs,dinucleotide
R1089 T1420 T1419 arg1Of motifs,cytosine-guanosine
R1090 T1420 T1421 arg1Of motifs,(
R1091 T1422 T1421 arg2Of CpG,(
R1092 T1423 T1421 arg3Of ),(
R1093 T1426 T1425 arg1Of in,especially
R1094 T1428 T1426 arg2Of islands,in
R1095 T1428 T1427 arg1Of islands,CpG
R1096 T1428 T1429 arg2Of islands,located
R1097 T1429 T1430 arg1Of located,in
R1098 T1432 T1430 arg2Of regions,in
R1099 T1432 T1431 arg1Of regions,promoter
R1100 T1434 T1433 arg1Of is,","
R1101 T1435 T1436 arg1Of one,of
R1102 T1435 T1444 arg1Of one,and
R1103 T1438 T1436 arg2Of mechanisms,of
R1104 T1438 T1437 arg1Of mechanisms,the
R1105 T1438 T1439 arg1Of mechanisms,of
R1106 T1438 T1442 arg1Of mechanisms,in
R1107 T1441 T1439 arg2Of regulation,of
R1108 T1441 T1440 arg1Of regulation,gene
R1109 T1443 T1442 arg2Of mammals,in
R1110 T1444 T1434 arg2Of and,is
R1111 T1447 T1444 arg2Of event,and
R1112 T1447 T1445 arg1Of event,a
R1113 T1447 T1446 arg1Of event,common
R1114 T1447 T1448 arg1Of event,of
R1115 T1447 T1451 arg1Of event,in
R1116 T1450 T1448 arg2Of silencing,of
R1117 T1450 T1449 arg1Of silencing,gene
R1118 T1453 T1451 arg2Of neoplasias,in
R1119 T1453 T1452 arg1Of neoplasias,human
R1120 T1453 T1454 arg1Of neoplasias,(
R1121 T1455 T1454 arg2Of "13,14",(
R1122 T1456 T1454 arg3Of ),(
R1123 T1458 T1457 arg2Of opposed,As
R1124 T1458 T1459 arg1Of opposed,to
R1125 T1461 T1459 arg2Of cells,to
R1126 T1461 T1460 arg1Of cells,normal
R1127 T1463 T1464 arg1Of hypermethylation,of
R1128 T1463 T1467 arg1Of hypermethylation,is
R1129 T1466 T1464 arg2Of islands,of
R1130 T1466 T1465 arg1Of islands,CpG
R1131 T1467 T1457 arg1Of is,As
R1132 T1467 T1462 arg1Of is,","
R1133 T1467 T1472 arg1Of is,in
R1134 T1470 T1469 arg1Of observed,frequently
R1135 T1471 T1467 arg2Of phenomenon,is
R1136 T1471 T1468 arg1Of phenomenon,a
R1137 T1471 T1470 arg1Of phenomenon,observed
R1138 T1475 T1472 arg2Of type,in
R1139 T1475 T1473 arg1Of type,every
R1140 T1475 T1474 arg1Of type,cancer
R1141 T1477 T1476 arg1Of novo,De
R1142 T1479 T1477 arg1Of methylation,novo
R1143 T1479 T1478 arg1Of methylation,DNA
R1144 T1479 T1480 arg1Of methylation,of
R1145 T1479 T1495 arg1Of methylation,is
R1146 T1479 T1497 arg2Of methylation,thought
R1147 T1479 T1499 arg1Of methylation,be
R1148 T1479 T1500 arg2Of methylation,involved
R1149 T1481 T1480 arg2Of genes,of
R1150 T1481 T1483 arg1Of genes,as
R1151 T1483 T1482 arg1Of as,such
R1152 T1485 T1484 arg1Of cycle,cell
R1153 T1485 T1486 arg1Of cycle,","
R1154 T1486 T1489 arg1Of ",",","
R1155 T1488 T1486 arg2Of repair,","
R1156 T1488 T1487 arg1Of repair,DNA
R1157 T1489 T1491 arg1Of ",",and
R1158 T1490 T1489 arg2Of apoptosis,","
R1159 T1491 T1483 arg2Of and,as
R1160 T1494 T1491 arg2Of genes,and
R1161 T1494 T1492 arg1Of genes,tumor
R1162 T1494 T1493 arg1Of genes,suppressor
R1163 T1497 T1495 arg2Of thought,is
R1164 T1497 T1496 arg1Of thought,therefore
R1165 T1500 T1497 arg3Of involved,thought
R1166 T1500 T1498 arg1Of involved,to
R1167 T1500 T1499 arg2Of involved,be
R1168 T1500 T1501 arg1Of involved,in
R1169 T1502 T1501 arg2Of tumorigenesis,in
R1170 T1502 T1503 arg1Of tumorigenesis,(
R1171 T1504 T1503 arg2Of 15–17,(
R1172 T1505 T1503 arg3Of ),(
R1173 T1506 T1507 arg1Of Examples,for
R1174 T1506 T1511 arg1Of Examples,are
R1175 T1509 T1508 arg1Of aberrated,such
R1176 T1510 T1507 arg2Of genes,for
R1177 T1510 T1509 arg1Of genes,aberrated
R1178 T1512 T1513 arg1Of MGMT,","
R1179 T1513 T1515 arg1Of ",",","
R1180 T1514 T1513 arg2Of DAPK,","
R1181 T1515 T1517 arg1Of ",",","
R1182 T1516 T1515 arg2Of p14ARF,","
R1183 T1517 T1519 arg1Of ",",","
R1184 T1518 T1517 arg2Of p15INK4b,","
R1185 T1519 T1521 arg1Of ",",","
R1186 T1520 T1519 arg2Of p16INK4a,","
R1187 T1521 T1523 arg1Of ",",","
R1188 T1522 T1521 arg2Of BRCA1,","
R1189 T1523 T1525 arg1Of ",",and
R1190 T1524 T1523 arg2Of CDH13,","
R1191 T1525 T1511 arg2Of and,are
R1192 T1526 T1525 arg2Of APAF-1,and
R1193 T1526 T1527 arg1Of APAF-1,(
R1194 T1528 T1527 arg2Of 17–19,(
R1195 T1529 T1527 arg3Of ),(
R1196 T1531 T1530 arg2Of CML,In
R1197 T1533 T1534 arg1Of methylation,is
R1198 T1533 T1535 arg2Of methylation,known
R1199 T1533 T1537 arg1Of methylation,regulate
R1200 T1535 T1534 arg2Of known,is
R1201 T1535 T1552 arg1Of known,and
R1202 T1537 T1535 arg3Of regulate,known
R1203 T1537 T1536 arg1Of regulate,to
R1204 T1538 T1537 arg2Of expression,regulate
R1205 T1538 T1539 arg1Of expression,of
R1206 T1541 T1540 arg1Of c-abl,the
R1207 T1541 T1542 arg1Of c-abl,","
R1208 T1542 T1546 arg1Of ",",and
R1209 T1545 T1542 arg2Of gene,","
R1210 T1545 T1543 arg1Of gene,the
R1211 T1545 T1544 arg1Of gene,bcr
R1212 T1546 T1539 arg2Of and,of
R1213 T1547 T1546 arg2Of others,and
R1214 T1547 T1548 arg1Of others,(
R1215 T1549 T1548 arg2Of 20–23,(
R1216 T1550 T1548 arg3Of ),(
R1217 T1552 T1530 arg1Of and,In
R1218 T1552 T1532 arg1Of and,","
R1219 T1552 T1551 arg1Of and,","
R1220 T1554 T1553 arg1Of extent,the
R1221 T1554 T1555 arg1Of extent,of
R1222 T1554 T1557 arg1Of extent,in
R1223 T1554 T1561 arg1Of extent,has
R1224 T1554 T1562 arg1Of extent,been
R1225 T1554 T1563 arg2Of extent,shown
R1226 T1554 T1565 arg1Of extent,be
R1227 T1554 T1566 arg2Of extent,associated
R1228 T1556 T1555 arg2Of methylation,of
R1229 T1560 T1557 arg2Of promoter,in
R1230 T1560 T1558 arg1Of promoter,the
R1231 T1560 T1559 arg1Of promoter,c-abl
R1232 T1563 T1552 arg2Of shown,and
R1233 T1563 T1561 arg2Of shown,has
R1234 T1563 T1562 arg2Of shown,been
R1235 T1566 T1563 arg3Of associated,shown
R1236 T1566 T1564 arg1Of associated,to
R1237 T1566 T1565 arg2Of associated,be
R1238 T1566 T1567 arg1Of associated,with
R1239 T1569 T1567 arg2Of disease,with
R1240 T1569 T1568 arg2Of disease,advanced
R1241 T1569 T1570 arg1Of disease,(
R1242 T1571 T1570 arg2Of 24,(
R1243 T1572 T1570 arg3Of ),(
R1244 T1573 T1574 arg1Of Hypermethylation,due
R1245 T1573 T1583 arg1Of Hypermethylation,remains
R1246 T1574 T1575 arg1Of due,to
R1247 T1576 T1574 arg2Of overexpression,due
R1248 T1576 T1577 arg1Of overexpression,of
R1249 T1576 T1580 arg1Of overexpression,(
R1250 T1579 T1577 arg2Of methyltransferases,of
R1251 T1579 T1578 arg1Of methyltransferases,DNA
R1252 T1581 T1580 arg2Of DNMTs,(
R1253 T1582 T1580 arg3Of ),(
R1254 T1586 T1583 arg2Of explanation,remains
R1255 T1586 T1584 arg1Of explanation,one
R1256 T1586 T1585 arg1Of explanation,possible
R1257 T1586 T1587 arg1Of explanation,for
R1258 T1589 T1588 arg1Of novo,de
R1259 T1590 T1587 arg2Of methylation,for
R1260 T1590 T1589 arg1Of methylation,novo
R1261 T1590 T1591 arg1Of methylation,in
R1262 T1592 T1591 arg2Of tumorigenesis,in
R1263 T1595 T1596 arg1Of DNMTs,have
R1264 T1595 T1597 arg1Of DNMTs,been
R1265 T1595 T1598 arg2Of DNMTs,shown
R1266 T1595 T1600 arg1Of DNMTs,be
R1267 T1595 T1601 arg2Of DNMTs,up-regulated
R1268 T1598 T1593 arg1Of shown,Recently
R1269 T1598 T1594 arg1Of shown,","
R1270 T1598 T1596 arg2Of shown,have
R1271 T1598 T1597 arg2Of shown,been
R1272 T1601 T1598 arg3Of up-regulated,shown
R1273 T1601 T1599 arg1Of up-regulated,to
R1274 T1601 T1600 arg2Of up-regulated,be
R1275 T1601 T1602 arg1Of up-regulated,in
R1276 T1604 T1602 arg2Of malignancies,in
R1277 T1604 T1603 arg1Of malignancies,hematopoietic
R1278 T1604 T1605 arg1Of malignancies,(
R1279 T1606 T1605 arg2Of 25,(
R1280 T1607 T1605 arg3Of ),(
R1281 T1609 T1608 arg1Of proteins,Methyl-CpG-binding
R1282 T1609 T1610 arg1Of proteins,(
R1283 T1609 T1613 arg1Of proteins,are
R1284 T1609 T1614 arg2Of proteins,thought
R1285 T1609 T1616 arg1Of proteins,inhibit
R1286 T1609 T1626 arg1Of proteins,are
R1287 T1609 T1628 arg2Of proteins,discussed
R1288 T1611 T1610 arg2Of MBPs,(
R1289 T1612 T1610 arg3Of ),(
R1290 T1614 T1613 arg2Of thought,are
R1291 T1614 T1625 arg1Of thought,and
R1292 T1616 T1614 arg3Of inhibit,thought
R1293 T1616 T1615 arg1Of inhibit,to
R1294 T1618 T1616 arg2Of binding,inhibit
R1295 T1618 T1617 arg1Of binding,the
R1296 T1618 T1619 arg1Of binding,of
R1297 T1618 T1622 arg1Of binding,to
R1298 T1621 T1619 arg2Of factors,of
R1299 T1621 T1620 arg1Of factors,transcriptional
R1300 T1624 T1622 arg2Of promoter,to
R1301 T1624 T1623 arg1Of promoter,the
R1302 T1628 T1625 arg2Of discussed,and
R1303 T1628 T1626 arg2Of discussed,are
R1304 T1628 T1627 arg1Of discussed,therefore
R1305 T1628 T1629 arg1Of discussed,as
R1306 T1631 T1629 arg2Of mechanism,as
R1307 T1631 T1630 arg1Of mechanism,one
R1308 T1631 T1632 arg1Of mechanism,of
R1309 T1631 T1635 arg1Of mechanism,by
R1310 T1634 T1632 arg2Of inhibition,of
R1311 T1634 T1633 arg1Of inhibition,transcription
R1312 T1636 T1635 arg2Of hypermethylation,by
R1313 T1636 T1637 arg1Of hypermethylation,(
R1314 T1638 T1637 arg2Of 26,(
R1315 T1639 T1637 arg3Of ),(
R1316 T1642 T1640 arg2Of work,In
R1317 T1642 T1641 arg1Of work,this
R1318 T1644 T1645 arg1Of we,studied
R1319 T1645 T1640 arg1Of studied,In
R1320 T1645 T1643 arg1Of studied,","
R1321 T1645 T1652 arg1Of studied,in
R1322 T1646 T1645 arg2Of mechanisms,studied
R1323 T1646 T1647 arg1Of mechanisms,of
R1324 T1651 T1647 arg2Of silencing,of
R1325 T1651 T1648 arg1Of silencing,IRF-4
R1326 T1651 T1649 arg1Of silencing,gene
R1327 T1651 T1650 arg1Of silencing,expression
R1328 T1654 T1652 arg2Of cells,in
R1329 T1654 T1653 arg1Of cells,leukemic
R1330 T1655 T1656 arg1Of We,analyzed
R1331 T1656 T1661 arg1Of analyzed,for
R1332 T1660 T1656 arg2Of region,analyzed
R1333 T1660 T1657 arg1Of region,the
R1334 T1660 T1658 arg1Of region,IRF-4
R1335 T1660 T1659 arg1Of region,promoter
R1336 T1663 T1662 arg1Of aberrations,genetic
R1337 T1663 T1664 arg1Of aberrations,and
R1338 T1664 T1661 arg2Of and,for
R1339 T1664 T1667 arg1Of and,in
R1340 T1666 T1664 arg2Of status,and
R1341 T1666 T1665 arg1Of status,methylational
R1342 T1668 T1669 arg1Of IRF-4-positive,and
R1343 T1670 T1669 arg2Of -negative,and
R1344 T1672 T1667 arg2Of cells,in
R1345 T1672 T1668 arg1Of cells,IRF-4-positive
R1346 T1672 T1670 arg1Of cells,-negative
R1347 T1672 T1671 arg1Of cells,hematopoietic
R2131 T2711 T2710 arg1Of lines,Cell
R2132 T2712 T2713 arg1Of K-562,","
R2133 T2713 T2715 arg1Of ",",and
R2134 T2714 T2713 arg2Of Jurkat,","
R2135 T2715 T2717 arg1Of and,were
R2136 T2715 T2718 arg2Of and,obtained
R2137 T2716 T2715 arg2Of U-937,and
R2138 T2718 T2717 arg2Of obtained,were
R2139 T2718 T2719 arg1Of obtained,from
R2140 T2718 T2742 arg1Of obtained,and
R2141 T2721 T2722 arg1Of ATCC,(
R2142 T2721 T2732 arg1Of ATCC,and
R2143 T2726 T2722 arg2Of Collection,(
R2144 T2726 T2723 arg1Of Collection,American
R2145 T2726 T2724 arg1Of Collection,Type
R2146 T2726 T2725 arg1Of Collection,Culture
R2147 T2726 T2727 arg1Of Collection,","
R2148 T2728 T2727 arg2Of Rockville,","
R2149 T2728 T2729 arg1Of Rockville,","
R2150 T2730 T2729 arg2Of USA,","
R2151 T2731 T2722 arg3Of ),(
R2152 T2732 T2719 arg2Of and,from
R2153 T2732 T2720 arg1Of and,the
R2154 T2733 T2734 arg1Of EM-2,","
R2155 T2734 T2736 arg1Of ",",","
R2156 T2735 T2734 arg2Of LAMA-84,","
R2157 T2736 T2738 arg1Of ",",","
R2158 T2737 T2736 arg2Of CML-T1,","
R2159 T2738 T2740 arg1Of ",",","
R2160 T2739 T2738 arg2Of BV-173,","
R2161 T2740 T2732 arg2Of ",",and
R2162 T2741 T2740 arg2Of SD-1,","
R2163 T2743 T2744 arg1Of RPMI-8226,from
R2164 T2743 T2752 arg1Of RPMI-8226,und
R2165 T2751 T2744 arg2Of Mikroorganismen,from
R2166 T2751 T2745 arg1Of Mikroorganismen,the
R2167 T2751 T2746 arg1Of Mikroorganismen,DSMZ
R2168 T2751 T2747 arg1Of Mikroorganismen,(
R2169 T2751 T2748 arg1Of Mikroorganismen,Deutsche
R2170 T2751 T2749 arg1Of Mikroorganismen,Sammlung
R2171 T2751 T2750 arg1Of Mikroorganismen,von
R2172 T2752 T2742 arg2Of und,and
R2173 T2754 T2753 arg1Of GmbH,Zellkulturen
R2174 T2754 T2755 arg1Of GmbH,","
R2175 T2755 T2752 arg2Of ",",und
R2176 T2755 T2757 arg1Of ",",","
R2177 T2756 T2755 arg2Of Braunschweig,","
R2178 T2758 T2757 arg2Of Germany,","
R2179 T2758 T2759 arg1Of Germany,)
R2180 T2762 T2760 arg1Of lines,All
R2181 T2762 T2761 arg1Of lines,cell
R2182 T2762 T2771 arg1Of lines,were
R2183 T2762 T2772 arg1Of lines,IRF-4-negative
R2184 T2765 T2766 arg1Of BV-173,","
R2185 T2766 T2768 arg1Of ",",and
R2186 T2767 T2766 arg2Of SD-1,","
R2187 T2768 T2764 arg2Of and,except
R2188 T2769 T2768 arg2Of RPMI-8226,and
R2189 T2771 T2763 arg1Of were,","
R2190 T2771 T2764 arg1Of were,except
R2191 T2771 T2770 arg1Of were,","
R2192 T2772 T2771 arg2Of IRF-4-negative,were
R2263 T2863 T2864 arg1Of culture,and
R2264 T2864 T2862 arg1Of and,Cell
R2265 T2865 T2864 arg2Of stimulation,and
R2266 T2868 T2866 arg1Of lines,All
R2267 T2868 T2867 arg1Of lines,cell
R2268 T2868 T2869 arg1Of lines,were
R2269 T2868 T2870 arg2Of lines,maintained
R2270 T2870 T2869 arg2Of maintained,were
R2271 T2870 T2871 arg1Of maintained,at
R2272 T2872 T2873 arg1Of 5,%
R2273 T2874 T2871 arg2Of CO2,at
R2274 T2874 T2872 arg1Of CO2,5
R2275 T2874 T2875 arg1Of CO2,in
R2276 T2874 T2879 arg1Of CO2,with
R2277 T2874 T2889 arg2Of CO2,supplemented
R2278 T2878 T2875 arg2Of medium,in
R2279 T2878 T2876 arg1Of medium,RPMI
R2280 T2878 T2877 arg1Of medium,1640
R2281 T2880 T2881 arg1Of 1,%
R2282 T2882 T2879 arg2Of glutamine,with
R2283 T2882 T2880 arg1Of glutamine,1
R2284 T2882 T2883 arg1Of glutamine,(
R2285 T2885 T2883 arg2Of Eggenstein,(
R2286 T2885 T2884 arg1Of Eggenstein,Gibco/BRL
R2287 T2885 T2886 arg1Of Eggenstein,","
R2288 T2887 T2886 arg2Of Germany,","
R2289 T2888 T2883 arg3Of ),(
R2290 T2889 T2890 arg1Of supplemented,with
R2291 T2889 T2903 arg1Of supplemented,(
R2292 T2891 T2892 arg1Of 10,%
R2293 T2895 T2891 arg1Of serum,10
R2294 T2895 T2893 arg1Of serum,fetal
R2295 T2895 T2894 arg1Of serum,calf
R2296 T2895 T2896 arg1Of serum,(
R2297 T2895 T2899 arg1Of serum,","
R2298 T2897 T2896 arg2Of Gibco/BRL,(
R2299 T2898 T2896 arg3Of ),(
R2300 T2899 T2890 arg2Of ",",with
R2301 T2900 T2901 arg1Of 1,%
R2302 T2902 T2899 arg2Of penicillin/streptomycin,","
R2303 T2902 T2900 arg1Of penicillin/streptomycin,1
R2304 T2904 T2905 arg1Of Biochrom,","
R2305 T2905 T2903 arg2Of ",",(
R2306 T2905 T2907 arg1Of ",",","
R2307 T2906 T2905 arg2Of Berlin,","
R2309 T2909 T2903 arg3Of ),(
R2321 T2917 T2921 arg1Of 5-aza-2-deoxycytidine,or
R2322 T2919 T2918 arg2Of AzadC,(
R2323 T2920 T2918 arg3Of ),(
R2324 T2921 T2916 arg2Of or,with
R2325 T2922 T2921 arg2Of 5-azacytidine,or
R2326 T2922 T2923 arg1Of 5-azacytidine,(
R2327 T2924 T2923 arg2Of AzaC,(
R2328 T2925 T2923 arg3Of ),(
R2329 T2927 T2928 arg1Of Sigma,","
R2330 T2928 T2926 arg2Of ",",(
R2331 T2928 T2930 arg1Of ",",","
R2332 T2929 T2928 arg2Of Taufkirchen,","
R2333 T2931 T2930 arg2Of Germany,","
R2334 T2932 T2926 arg3Of ),(
R2335 T2936 T2933 arg2Of periods,for
R2336 T2936 T2934 arg1Of periods,different
R2337 T2936 T2935 arg1Of periods,time
R2338 T2937 T2938 arg1Of Owing,to
R2339 T2937 T2945 arg1Of Owing,re-added
R2340 T2940 T2938 arg2Of chemical,to
R2341 T2940 T2939 arg1Of chemical,their
R2342 T2941 T2937 arg2Of instability,Owing
R2343 T2941 T2944 arg2Of instability,were
R2344 T2943 T2942 arg1Of substances,fresh
R2345 T2943 T2944 arg1Of substances,were
R2346 T2948 T2945 arg2Of h,re-added
R2347 T2948 T2946 arg1Of h,every
R2348 T2948 T2947 arg1Of h,24
R2455 T3081 T3080 arg2Of mutation,or
R2456 T3083 T3084 arg1Of we,PCR-amplified
R2457 T3084 T3067 arg1Of PCR-amplified,For
R2458 T3084 T3082 arg1Of PCR-amplified,","
R2459 T3086 T3084 arg2Of fragments,PCR-amplified
R2460 T3086 T3085 arg1Of fragments,two
R2461 T3086 T3087 arg1Of fragments,from
R2462 T3089 T3087 arg2Of DNA,from
R2463 T3089 T3088 arg1Of DNA,genomic
R2464 T3089 T3090 arg1Of DNA,","
R2465 T3089 T3091 arg1Of DNA,which
R2466 T3089 T3092 arg1Of DNA,was
R2467 T3089 T3093 arg2Of DNA,extracted
R2468 T3093 T3092 arg2Of extracted,was
R2469 T3093 T3094 arg1Of extracted,from
R2470 T3093 T3109 arg1Of extracted,as
R2471 T3097 T3094 arg2Of lines,from
R2472 T3097 T3095 arg2Of lines,depicted
R2473 T3097 T3096 arg1Of lines,cell
R2474 T3097 T3098 arg1Of lines,with
R2475 T3097 T3102 arg1Of lines,(
R2476 T3101 T3098 arg2Of kit,with
R2477 T3101 T3099 arg1Of kit,a
R2478 T3101 T3100 arg1Of kit,commercial
R2479 T3103 T3102 arg2Of Qiagen,(
R2480 T3103 T3104 arg1Of Qiagen,","
R2481 T3103 T3106 arg1Of Qiagen,","
R2482 T3105 T3104 arg2Of Hilde,","
R2483 T3107 T3106 arg2Of Germany,","
R2484 T3108 T3102 arg3Of ),(
R2485 T3110 T3109 arg2Of recommended,as
R2486 T3112 T3111 arg1Of primers,The
R2487 T3112 T3113 arg1Of primers,were
R2488 T3112 T3114 arg1Of primers,1-forward
R2489 T3113 T3115 arg1Of were,:
R2490 T3114 T3113 arg2Of 1-forward,were
R2491 T3116 T3117 arg1Of 5′-TTGAGATGGAGTCTTGCTCTGT-3′,","
R2492 T3117 T3119 arg1Of ",",:
R2493 T3118 T3117 arg2Of 1-reverse,","
R2494 T3120 T3121 arg1Of 5′-CCAGGACCTCAGGAGGCCAGTCA-3′,;
R2495 T3121 T3123 arg1Of ;,:
R2496 T3122 T3121 arg2Of 2-forward,;
R2497 T3124 T3125 arg1Of 5′-AGCGGTGAAACTGAGAGTGCGAGGT-3′,","
R2498 T3125 T3127 arg1Of ",",:
R2499 T3126 T3125 arg2Of 2-reverse,","
R2500 T3130 T3129 arg1Of products,The
R2501 T3130 T3131 arg1Of products,were
R2502 T3130 T3132 arg2Of products,cloned
R2503 T3132 T3131 arg2Of cloned,were
R2504 T3132 T3133 arg1Of cloned,with
R2505 T3138 T3133 arg2Of kit’,with
R2506 T3138 T3134 arg1Of kit’,the
R2507 T3138 T3135 arg1Of kit’,‘TOPO
R2508 T3138 T3136 arg1Of kit’,TA
R2509 T3138 T3137 arg1Of kit’,cloning
R2510 T3138 T3139 arg1Of kit’,(
R2511 T3140 T3139 arg2Of Invitrogen,(
R2512 T3140 T3141 arg1Of Invitrogen,","
R2513 T3140 T3143 arg1Of Invitrogen,","
R2514 T3142 T3141 arg2Of Groningen,","
R2515 T3145 T3143 arg2Of Netherlands,","
R2516 T3145 T3144 arg1Of Netherlands,The
R2517 T3146 T3139 arg3Of ),(
R2518 T3149 T3147 arg2Of amplification,After
R2519 T3149 T3148 arg1Of amplification,bacterial
R2520 T3149 T3150 arg1Of amplification,of
R2521 T3149 T3155 arg1Of amplification,by
R2522 T3154 T3150 arg2Of fragments,of
R2523 T3154 T3151 arg1Of fragments,the
R2524 T3154 T3152 arg2Of fragments,cloned
R2525 T3154 T3153 arg1Of fragments,PCR
R2526 T3157 T3155 arg2Of procedures,by
R2527 T3157 T3156 arg1Of procedures,standard
R2528 T3161 T3159 arg1Of three,at
R2529 T3161 T3160 arg1Of three,least
R2530 T3162 T3161 arg1Of clones,three
R2531 T3162 T3163 arg1Of clones,from
R2532 T3162 T3166 arg1Of clones,were
R2533 T3162 T3167 arg2Of clones,sequenced
R2534 T3165 T3163 arg2Of sample,from
R2535 T3165 T3164 arg1Of sample,each
R2536 T3167 T3147 arg1Of sequenced,After
R2537 T3167 T3158 arg1Of sequenced,","
R2538 T3167 T3166 arg2Of sequenced,were
R2539 T3167 T3168 arg1Of sequenced,with
R2540 T3167 T3172 arg1Of sequenced,(
R2541 T3167 T3185 arg1Of sequenced,as
R2542 T3171 T3168 arg2Of sequencer,with
R2543 T3171 T3169 arg1Of sequencer,an
R2544 T3171 T3170 arg2Of sequencer,automated
R2545 T3174 T3173 arg1Of Prism,ABI
R2546 T3174 T3175 arg1Of Prism,377
R2547 T3174 T3176 arg1Of Prism,","
R2548 T3174 T3179 arg1Of Prism,","
R2549 T3178 T3176 arg2Of Bio-systems,","
R2550 T3178 T3177 arg1Of Bio-systems,Applied
R2551 T3179 T3172 arg2Of ",",(
R2552 T3179 T3182 arg1Of ",",","
R2553 T3179 T3183 arg1Of ",",USA
R2554 T3181 T3179 arg2Of City,","
R2555 T3181 T3180 arg1Of City,Foster
R2556 T3184 T3172 arg3Of ),(
R2557 T3186 T3185 arg2Of recommended,as
R2558 T3189 T3186 arg1Of manufacturer,recommended
R2559 T3189 T3187 arg2Of manufacturer,by
R2560 T3189 T3188 arg1Of manufacturer,the
R2749 T3451 T3450 arg1Of analysis,Expression
R2750 T3453 T3452 arg1Of analyze,To
R2751 T3457 T3453 arg2Of level,analyze
R2752 T3457 T3454 arg1Of level,the
R2753 T3457 T3455 arg1Of level,IRF-4
R2754 T3457 T3456 arg1Of level,transcriptional
R2755 T3459 T3453 arg1Of RNA,analyze
R2756 T3459 T3460 arg1Of RNA,was
R2757 T3459 T3461 arg2Of RNA,extracted
R2758 T3461 T3452 modOf extracted,To
R2759 T3461 T3458 arg1Of extracted,","
R2760 T3461 T3460 arg2Of extracted,was
R2761 T3461 T3462 arg1Of extracted,from
R2762 T3463 T3462 arg2Of cells,from
R2763 T3463 T3464 arg1Of cells,using
R2764 T3467 T3464 arg2Of RNAzol-kit,using
R2765 T3467 T3465 arg1Of RNAzol-kit,the
R2766 T3467 T3466 arg1Of RNAzol-kit,commercial
R2767 T3467 T3468 arg1Of RNAzol-kit,(
R2768 T3469 T3470 arg1Of Paesel,","
R2769 T3470 T3468 arg2Of ",",(
R2770 T3470 T3472 arg1Of ",",","
R2771 T3471 T3470 arg2Of Frankfurt,","
R2772 T3473 T3472 arg2Of Germany,","
R2773 T3474 T3468 arg3Of ),(
R2774 T3476 T3475 arg1Of aliquot,An
R2775 T3476 T3477 arg1Of aliquot,of
R2776 T3476 T3482 arg1Of aliquot,was
R2777 T3476 T3483 arg2Of aliquot,used
R2778 T3481 T3477 arg2Of RNA,of
R2779 T3481 T3478 arg1Of RNA,1
R2780 T3481 T3479 arg1Of RNA,μg
R2781 T3481 T3480 arg1Of RNA,total
R2782 T3483 T3482 arg2Of used,was
R2783 T3483 T3484 arg1Of used,for
R2784 T3486 T3484 arg2Of synthesis,for
R2785 T3486 T3485 arg1Of synthesis,cDNA
R2786 T3487 T3483 arg3Of as,used
R2787 T3488 T3487 arg2Of described,as
R2788 T3488 T3489 arg1Of described,previously
R2789 T3489 T3490 arg1Of previously,(
R2790 T3491 T3490 arg2Of 27,(
R2791 T3492 T3490 arg3Of ),(
R2792 T3495 T3493 arg1Of analysis,RNA
R2793 T3495 T3494 arg1Of analysis,expression
R2794 T3495 T3496 arg1Of analysis,for
R2795 T3495 T3498 arg1Of analysis,and
R2796 T3497 T3496 arg2Of IRF-4,for
R2797 T3498 T3503 arg1Of and,was
R2798 T3498 T3504 arg2Of and,carried
R2799 T3502 T3498 arg2Of β-actin,and
R2800 T3502 T3499 arg1Of β-actin,the
R2801 T3502 T3500 arg1Of β-actin,reference
R2802 T3502 T3501 arg1Of β-actin,gene
R2803 T3504 T3503 arg2Of carried,was
R2804 T3504 T3505 arg1Of carried,out
R2805 T3504 T3509 arg1Of carried,as
R2806 T3508 T3504 arg1Of PCR,carried
R2807 T3508 T3506 arg2Of PCR,by
R2808 T3508 T3507 arg1Of PCR,semi-quantitative
R2809 T3510 T3509 arg2Of described,as
R2810 T3510 T3511 arg1Of described,previously
R2811 T3511 T3512 arg1Of previously,(
R2812 T3513 T3512 arg2Of "3,27",(
R2813 T3514 T3512 arg3Of ),(
R2814 T3516 T3515 arg1Of products,PCR
R2815 T3516 T3517 arg1Of products,were
R2816 T3516 T3518 arg2Of products,verified
R2817 T3518 T3517 arg2Of verified,were
R2818 T3521 T3518 arg1Of sequencing,verified
R2819 T3521 T3519 arg2Of sequencing,by
R2820 T3521 T3520 arg2Of sequencing,automated
R2821 T3523 T3522 arg1Of primers,PCR
R2822 T3523 T3524 arg1Of primers,and
R2823 T3524 T3526 arg1Of and,for
R2824 T3524 T3547 arg1Of and,were
R2825 T3524 T3548 arg2Of and,published
R2826 T3525 T3524 arg2Of conditions,and
R2827 T3528 T3526 arg2Of analysis,for
R2828 T3528 T3527 arg1Of analysis,expression
R2829 T3528 T3529 arg1Of analysis,of
R2830 T3530 T3531 arg1Of DNMT,or
R2831 T3531 T3529 arg2Of or,of
R2832 T3531 T3533 arg1Of or,(
R2833 T3532 T3531 arg2Of MBP,or
R2834 T3535 T3534 arg1Of DNMT3A,DNMT1
R2835 T3535 T3536 arg1Of DNMT3A,","
R2836 T3536 T3538 arg1Of ",",","
R2837 T3537 T3536 arg2Of DNMT3B,","
R2838 T3538 T3540 arg1Of ",",","
R2839 T3539 T3538 arg2Of MeCP,","
R2840 T3540 T3542 arg1Of ",",","
R2841 T3541 T3540 arg2Of MBD1,","
R2842 T3542 T3544 arg1Of ",",and
R2843 T3543 T3542 arg2Of MBD2,","
R2844 T3544 T3533 arg2Of and,(
R2845 T3545 T3544 arg2Of MBD4,and
R2846 T3546 T3533 arg3Of ),(
R2847 T3548 T3547 arg2Of published,were
R2848 T3548 T3549 arg1Of published,elsewhere
R2849 T3549 T3550 arg1Of elsewhere,(
R2850 T3551 T3550 arg2Of 28,(
R2851 T3552 T3550 arg3Of ),(
R2852 T3554 T3553 arg2Of analysis,For
R2853 T3554 T3555 arg1Of analysis,of
R2854 T3558 T3555 arg2Of expression,of
R2855 T3558 T3556 arg1Of expression,IRF-4
R2856 T3558 T3557 arg1Of expression,protein
R2857 T3563 T3560 arg1Of assay,a
R2858 T3563 T3561 arg1Of assay,standard
R2859 T3563 T3562 arg1Of assay,immunoblotting
R2860 T3563 T3564 arg1Of assay,was
R2861 T3563 T3565 arg2Of assay,performed
R2862 T3565 T3553 arg1Of performed,For
R2863 T3565 T3559 arg1Of performed,","
R2864 T3565 T3564 arg2Of performed,was
R2865 T3565 T3566 arg1Of performed,as
R2866 T3567 T3566 arg2Of described,as
R2867 T3567 T3568 arg1Of described,previously
R2868 T3568 T3569 arg1Of previously,(
R2869 T3570 T3569 arg2Of 29,(
R2870 T3571 T3569 arg3Of ),(
R2871 T3575 T3574 arg1Of lysates,protein
R2872 T3575 T3576 arg1Of lysates,were
R2873 T3575 T3577 arg2Of lysates,generated
R2874 T3577 T3572 arg1Of generated,Briefly
R2875 T3577 T3573 arg1Of generated,","
R2876 T3577 T3576 arg2Of generated,were
R2877 T3577 T3578 arg1Of generated,by
R2878 T3579 T3578 arg2Of incubating,by
R2879 T3579 T3618 arg1Of incubating,for
R2880 T3583 T3579 arg2Of cells,incubating
R2881 T3583 T3580 arg1Of cells,1
R2882 T3583 T3581 arg1Of cells,×
R2883 T3583 T3582 arg1Of cells,106
R2884 T3583 T3584 arg1Of cells,in
R2885 T3583 T3589 arg1Of cells,(
R2886 T3588 T3584 arg2Of buffer,in
R2887 T3588 T3585 arg1Of buffer,100
R2888 T3588 T3586 arg1Of buffer,µl
R2889 T3588 T3587 arg1Of buffer,RIPA
R2890 T3590 T3591 arg1Of 1,%
R2891 T3592 T3590 arg1Of NP-40,1
R2892 T3592 T3593 arg1Of NP-40,","
R2893 T3593 T3597 arg1Of ",",","
R2894 T3594 T3595 arg1Of 0.5,%
R2895 T3596 T3593 arg2Of sodiumdesoxycholate,","
R2896 T3596 T3594 arg1Of sodiumdesoxycholate,0.5
R2897 T3597 T3601 arg1Of ",",","
R2898 T3598 T3599 arg1Of 0.1,%
R2899 T3600 T3597 arg2Of SDS,","
R2900 T3600 T3598 arg1Of SDS,0.1
R2901 T3601 T3606 arg1Of ",",","
R2902 T3605 T3601 arg2Of fluoride,","
R2903 T3605 T3602 arg1Of fluoride,100
R2904 T3605 T3603 arg1Of fluoride,µg/ml
R2905 T3605 T3604 arg1Of fluoride,phenylmethylsulfonyl
R2906 T3606 T3610 arg1Of ",",","
R2907 T3609 T3606 arg2Of protease-inhibitory-mix,","
R2908 T3609 T3607 arg1Of protease-inhibitory-mix,10
R2909 T3609 T3608 arg1Of protease-inhibitory-mix,µl/ml
R2910 T3610 T3589 arg2Of ",",(
R2911 T3613 T3610 arg2Of sodiumorthovanadate,","
R2912 T3613 T3611 arg1Of sodiumorthovanadate,1
R2913 T3613 T3612 arg1Of sodiumorthovanadate,µmol/ml
R2914 T3613 T3614 arg1Of sodiumorthovanadate,in
R2915 T3616 T3614 arg2Of saline,in
R2916 T3616 T3615 arg1Of saline,phosphate-buffered
R2917 T3617 T3589 arg3Of ),(
R2918 T3620 T3618 arg2Of min,for
R2919 T3620 T3619 arg1Of min,30
R2920 T3620 T3621 arg1Of min,on
R2921 T3622 T3621 arg2Of ice,on
R2922 T3624 T3623 arg2Of centrifugation,After
R2923 T3627 T3626 arg1Of concentration,protein
R2924 T3627 T3628 arg1Of concentration,of
R2925 T3627 T3631 arg1Of concentration,was
R2926 T3627 T3632 arg2Of concentration,determined
R2927 T3630 T3628 arg2Of supernatant,of
R2928 T3630 T3629 arg1Of supernatant,the
R2929 T3632 T3623 arg1Of determined,After
R2930 T3632 T3625 arg1Of determined,","
R2931 T3632 T3631 arg2Of determined,was
R2932 T3632 T3635 arg1Of determined,(
R2933 T3632 T3642 arg1Of determined,as
R2934 T3634 T3632 arg1Of BCA-method,determined
R2935 T3634 T3633 arg2Of BCA-method,by
R2936 T3636 T3637 arg1Of Pierce,","
R2937 T3637 T3635 arg2Of ",",(
R2938 T3637 T3639 arg1Of ",",","
R2939 T3638 T3637 arg2Of Rockford,","
R2940 T3640 T3639 arg2Of IL,","
R2941 T3641 T3635 arg3Of ),(
R2942 T3643 T3642 arg2Of recommended,as
R2943 T3645 T3644 arg1Of lysates,Protein
R2944 T3645 T3646 arg1Of lysates,(
R2945 T3645 T3650 arg1Of lysates,were
R2946 T3645 T3651 arg2Of lysates,electrophoresed
R2947 T3645 T3656 arg2Of lysates,transferred
R2948 T3648 T3646 arg2Of µg,(
R2949 T3648 T3647 arg1Of µg,70–100
R2950 T3649 T3646 arg3Of ),(
R2951 T3651 T3652 arg1Of electrophoresed,on
R2952 T3651 T3655 arg1Of electrophoresed,and
R2953 T3654 T3652 arg2Of gels,on
R2954 T3654 T3653 arg1Of gels,polyacrylamide
R2955 T3655 T3650 arg2Of and,were
R2956 T3656 T3655 arg2Of transferred,and
R2957 T3656 T3657 arg1Of transferred,to
R2958 T3659 T3657 arg2Of PVDF-membrane,to
R2959 T3659 T3658 arg1Of PVDF-membrane,a
R2960 T3659 T3660 arg1Of PVDF-membrane,(
R2961 T3662 T3660 arg2Of P,(
R2962 T3662 T3661 arg1Of P,Immobilon
R2963 T3662 T3663 arg1Of P,","
R2964 T3662 T3666 arg1Of P,;
R2965 T3665 T3663 arg2Of µm,","
R2966 T3665 T3664 arg1Of µm,0.45
R2967 T3667 T3666 arg2Of Millipore,;
R2968 T3667 T3668 arg1Of Millipore,","
R2969 T3669 T3668 arg2Of Eschborn,","
R2970 T3669 T3670 arg1Of Eschborn,","
R2971 T3671 T3670 arg2Of Germany,","
R2972 T3672 T3660 arg3Of ),(
R2973 T3673 T3674 arg1Of Membranes,were
R2974 T3673 T3675 arg2Of Membranes,blocked
R2975 T3673 T3715 arg2Of Membranes,incubated
R2976 T3675 T3676 arg1Of blocked,with
R2977 T3675 T3713 arg1Of blocked,and
R2978 T3678 T3676 arg2Of %,with
R2979 T3678 T3677 arg1Of %,2.5
R2980 T3678 T3679 arg1Of %,blocking
R2981 T3678 T3690 arg1Of %,(
R2982 T3680 T3679 arg2Of reagent,blocking
R2983 T3680 T3681 arg1Of reagent,(
R2984 T3680 T3687 arg1Of reagent,in
R2985 T3683 T3681 arg2Of Mannheim,(
R2986 T3683 T3682 arg1Of Mannheim,Boehringer
R2987 T3683 T3684 arg1Of Mannheim,","
R2988 T3685 T3684 arg2Of Germany,","
R2989 T3686 T3681 arg3Of ),(
R2990 T3689 T3687 arg2Of buffer,in
R2991 T3689 T3688 arg1Of buffer,TBST
R2992 T3693 T3691 arg1Of Tris–HCL,4.44
R2993 T3693 T3692 arg1Of Tris–HCL,g/l
R2994 T3693 T3694 arg1Of Tris–HCL,","
R2995 T3694 T3698 arg1Of ",",","
R2996 T3697 T3694 arg2Of TrisOH,","
R2997 T3697 T3695 arg1Of TrisOH,2.65
R2998 T3697 T3696 arg1Of TrisOH,g/l
R2999 T3698 T3702 arg1Of ",",","
R3000 T3701 T3698 arg2Of NaCl,","
R3001 T3701 T3699 arg1Of NaCl,8.07
R3002 T3701 T3700 arg1Of NaCl,g/l
R3003 T3702 T3706 arg1Of ",",and
R3004 T3703 T3704 arg1Of 0.2,g/l
R3005 T3705 T3702 arg2Of KCl,","
R3006 T3705 T3703 arg1Of KCl,0.2
R3007 T3706 T3708 arg1Of and,µl/l
R3008 T3707 T3706 arg2Of 500,and
R3009 T3708 T3690 arg2Of µl/l,(
R3010 T3708 T3710 arg1Of µl/l,in
R3011 T3709 T3708 arg2Of Tween-20,µl/l
R3012 T3711 T3710 arg2Of H2O,in
R3013 T3712 T3690 arg3Of ),(
R3014 T3713 T3674 arg2Of and,were
R3015 T3713 T3739 arg1Of and,respectively
R3016 T3715 T3713 arg2Of incubated,and
R3017 T3715 T3714 arg1Of incubated,subsequently
R3018 T3715 T3716 arg1Of incubated,with
R3019 T3715 T3738 arg1Of incubated,","
R3020 T3718 T3716 arg2Of antibody,with
R3021 T3718 T3717 arg1Of antibody,primary
R3022 T3718 T3719 arg1Of antibody,as
R3023 T3723 T3721 arg1Of peroxidase-conjugated,and
R3024 T3723 T3722 arg1Of peroxidase-conjugated,horseradish
R3025 T3725 T3720 arg2Of antibody,indicated
R3026 T3725 T3723 arg1Of antibody,peroxidase-conjugated
R3027 T3725 T3724 arg1Of antibody,secondary
R3028 T3725 T3726 arg1Of antibody,","
R3029 T3726 T3719 arg2Of ",",as
R3030 T3726 T3731 arg1Of ",",(
R3031 T3727 T3728 arg1Of anti-mouse,or
R3032 T3729 T3728 arg2Of anti-goat,or
R3033 T3730 T3726 arg2Of IgG,","
R3034 T3730 T3727 arg1Of IgG,anti-mouse
R3035 T3730 T3729 arg1Of IgG,anti-goat
R3036 T3732 T3733 arg1Of DAKO,","
R3037 T3733 T3735 arg1Of ",",","
R3038 T3734 T3733 arg2Of Hamburg,","
R3039 T3735 T3731 arg2Of ",",(
R3040 T3736 T3735 arg2Of Germany,","
R3041 T3737 T3731 arg3Of ),(
R3042 T3741 T3740 arg1Of membranes,The
R3043 T3741 T3742 arg1Of membranes,were
R3044 T3741 T3744 arg2Of membranes,developed
R3045 T3744 T3742 arg2Of developed,were
R3046 T3744 T3743 arg1Of developed,then
R3047 T3744 T3745 arg1Of developed,with
R3048 T3749 T3745 arg2Of kit,with
R3049 T3749 T3746 arg1Of kit,an
R3050 T3749 T3747 arg1Of kit,ECL
R3051 T3749 T3748 arg1Of kit,detection
R3052 T3749 T3750 arg1Of kit,(
R3053 T3753 T3750 arg2Of Biotech,(
R3054 T3753 T3751 arg1Of Biotech,Amersham
R3055 T3753 T3752 arg1Of Biotech,Pharmacia
R3056 T3753 T3754 arg1Of Biotech,","
R3057 T3755 T3754 arg2Of Freiburg,","
R3058 T3755 T3756 arg1Of Freiburg,","
R3059 T3757 T3756 arg2Of Germany,","
R3060 T3758 T3750 arg3Of ),(
R3061 T3761 T3759 arg1Of antibodies,The
R3062 T3761 T3760 arg1Of antibodies,primary
R3063 T3761 T3762 arg1Of antibodies,were
R3064 T3764 T3763 arg1Of anti-IRF-4/ICSAT,goat
R3065 T3764 T3765 arg1Of anti-IRF-4/ICSAT,(
R3066 T3764 T3768 arg1Of anti-IRF-4/ICSAT,(
R3067 T3764 T3778 arg1Of anti-IRF-4/ICSAT,and
R3068 T3766 T3765 arg2Of M-17,(
R3069 T3767 T3765 arg3Of ),(
R3070 T3771 T3768 arg2Of Biotechnology,(
R3071 T3771 T3769 arg1Of Biotechnology,Santa
R3072 T3771 T3770 arg1Of Biotechnology,Cruz
R3073 T3771 T3772 arg1Of Biotechnology,","
R3074 T3774 T3772 arg2Of Cruz,","
R3075 T3774 T3773 arg1Of Cruz,Santa
R3076 T3774 T3775 arg1Of Cruz,","
R3077 T3776 T3775 arg2Of CA,","
R3078 T3777 T3768 arg3Of ),(
R3079 T3778 T3762 arg2Of and,were
R3080 T3778 T3784 arg1Of and,(
R3081 T3782 T3778 arg2Of AC-74,and
R3082 T3782 T3779 arg1Of AC-74,mouse
R3083 T3782 T3780 arg1Of AC-74,anti-β-actin
R3084 T3782 T3781 arg2Of AC-74,(
R3085 T3783 T3781 arg3Of ),(
R3086 T3785 T3784 arg2Of Sigma,(
R3087 T3786 T3784 arg3Of ),(
R3523 T4372 T4371 arg1Of restriction-PCR-assay,Methylation-specific
R3524 T4373 T4374 arg1Of DNA,was
R3525 T4373 T4375 arg2Of DNA,extracted
R3526 T4375 T4374 arg2Of extracted,was
R3527 T4375 T4376 arg1Of extracted,with
R3528 T4375 T4383 arg1Of extracted,as
R3529 T4379 T4376 arg2Of kit,with
R3530 T4379 T4377 arg1Of kit,a
R3531 T4379 T4378 arg1Of kit,commercial
R3532 T4379 T4380 arg1Of kit,(
R3533 T4381 T4380 arg2Of Qiagen,(
R3534 T4382 T4380 arg3Of ),(
R3535 T4384 T4383 arg2Of recommended,as
R3536 T4388 T4386 arg1Of ability,the
R3537 T4388 T4387 arg1Of ability,restriction
R3538 T4388 T4389 arg1Of ability,of
R3539 T4388 T4392 arg1Of ability,is
R3540 T4388 T4393 arg2Of ability,inhibited
R3541 T4391 T4389 arg2Of endonucleases,of
R3542 T4391 T4390 arg1Of endonucleases,several
R3543 T4393 T4385 arg2Of inhibited,Since
R3544 T4393 T4392 arg2Of inhibited,is
R3545 T4395 T4393 arg1Of methylation,inhibited
R3546 T4395 T4394 arg2Of methylation,by
R3547 T4395 T4396 arg1Of methylation,of
R3548 T4399 T4396 arg2Of sequence,of
R3549 T4399 T4397 arg1Of sequence,their
R3550 T4399 T4398 arg1Of sequence,target
R3551 T4401 T4402 arg1Of we,used
R3552 T4402 T4385 arg1Of used,Since
R3553 T4402 T4400 arg1Of used,","
R3554 T4405 T4403 arg1Of HpaII,methylation-sensitive
R3555 T4405 T4404 arg1Of HpaII,enzymes
R3556 T4405 T4406 arg1Of HpaII,and
R3557 T4406 T4409 arg1Of and,and
R3558 T4408 T4406 arg2Of Bsp143II,and
R3559 T4408 T4407 arg1Of Bsp143II,HaeII-isochizomer
R3560 T4409 T4402 arg2Of and,used
R3561 T4409 T4420 arg1Of and,(
R3562 T4410 T4409 arg2Of Bsh1236I,and
R3563 T4410 T4411 arg1Of Bsh1236I,(
R3564 T4413 T4411 arg2Of Fermentas,(
R3565 T4413 T4412 arg1Of Fermentas,MBI
R3566 T4413 T4414 arg1Of Fermentas,","
R3567 T4416 T4414 arg2Of Leon-Rot,","
R3568 T4416 T4415 arg1Of Leon-Rot,St
R3569 T4416 T4417 arg1Of Leon-Rot,","
R3570 T4418 T4417 arg2Of Germany,","
R3571 T4419 T4411 arg3Of ),(
R3572 T4421 T4420 arg2Of "20,24",(
R3573 T4422 T4420 arg3Of ),(
R3574 T4424 T4423 arg2Of control,As
R3575 T4424 T4432 arg1Of control,with
R3576 T4428 T4425 arg1Of MspI,the
R3577 T4428 T4426 arg1Of MspI,methylation-resistant
R3578 T4428 T4427 arg1Of MspI,enzyme
R3579 T4428 T4429 arg1Of MspI,and
R3580 T4429 T4424 arg2Of and,control
R3581 T4431 T4429 arg2Of enzyme,and
R3582 T4431 T4430 arg1Of enzyme,an
R3583 T4435 T4432 arg2Of site,with
R3584 T4435 T4433 arg1Of site,no
R3585 T4435 T4434 arg1Of site,recognition
R3586 T4435 T4436 arg1Of site,in
R3587 T4439 T4436 arg2Of promoter,in
R3588 T4439 T4437 arg1Of promoter,the
R3589 T4439 T4438 arg1Of promoter,target
R3590 T4441 T4443 arg1Of EcoRI,were
R3591 T4441 T4444 arg2Of EcoRI,used
R3592 T4444 T4423 arg1Of used,As
R3593 T4444 T4440 arg1Of used,","
R3594 T4444 T4442 arg1Of used,","
R3595 T4444 T4443 arg2Of used,were
R3596 T4445 T4446 arg1Of DNA,(
R3597 T4445 T4450 arg1Of DNA,was
R3598 T4445 T4451 arg2Of DNA,digested
R3599 T4448 T4446 arg2Of µg,(
R3600 T4448 T4447 arg1Of µg,0.8
R3601 T4449 T4446 arg3Of ),(
R3602 T4451 T4450 arg2Of digested,was
R3603 T4451 T4462 arg1Of digested,","
R3604 T4451 T4463 modOf digested,to
R3605 T4451 T4467 arg1Of digested,","
R3606 T4451 T4471 arg1Of digested,for
R3607 T4454 T4453 arg1Of U,40
R3608 T4457 T4451 arg1Of enzyme,digested
R3609 T4457 T4452 arg2Of enzyme,by
R3610 T4457 T4454 arg1Of enzyme,U
R3611 T4457 T4455 arg1Of enzyme,the
R3612 T4457 T4456 arg1Of enzyme,respective
R3613 T4457 T4458 arg1Of enzyme,for
R3614 T4457 T4461 arg1Of enzyme,and
R3615 T4460 T4458 arg2Of h,for
R3616 T4460 T4459 arg1Of h,6
R3617 T4464 T4463 arg1Of ensure,to
R3618 T4466 T4464 arg2Of cleavage,ensure
R3619 T4466 T4465 arg1Of cleavage,complete
R3620 T4470 T4468 arg1Of U,additional
R3621 T4470 T4469 arg1Of U,20
R3622 T4471 T4470 arg1Of for,U
R3623 T4473 T4471 arg2Of h,for
R3624 T4473 T4472 arg1Of h,16
R3625 T4475 T4474 arg1Of 100,Thereafter
R3626 T4476 T4475 arg1Of ng,100
R3627 T4476 T4477 arg1Of ng,of
R3628 T4476 T4480 arg1Of ng,was
R3629 T4476 T4481 arg2Of ng,used
R3630 T4479 T4477 arg2Of DNA,of
R3631 T4479 T4478 arg1Of DNA,digested
R3632 T4481 T4480 arg2Of used,was
R3633 T4481 T4482 arg1Of used,to
R3634 T4481 T4510 arg1Of used,)
R3635 T4485 T4482 arg2Of amplification,to
R3636 T4485 T4483 arg1Of amplification,a
R3637 T4485 T4484 arg1Of amplification,PCR
R3638 T4485 T4486 arg1Of amplification,of
R3639 T4485 T4489 arg1Of amplification,(
R3640 T4485 T4494 arg1Of amplification,spanning
R3641 T4485 T4507 modOf amplification,see
R3642 T4488 T4486 arg2Of fragments,of
R3643 T4488 T4487 arg1Of fragments,two
R3644 T4490 T4491 arg1Of F1,and
R3645 T4491 T4489 arg2Of and,(
R3646 T4492 T4491 arg2Of F2,and
R3647 T4493 T4489 arg3Of ),(
R3648 T4494 T4506 arg1Of spanning,;
R3649 T4495 T4494 arg2Of part,spanning
R3650 T4495 T4496 arg1Of part,of
R3651 T4501 T4500 arg2Of 30,(
R3652 T4502 T4500 arg3Of ),(
R3653 T4505 T4496 arg2Of U52683,of
R3654 T4505 T4497 arg1Of U52683,the
R3655 T4505 T4498 arg1Of U52683,IRF-4
R3656 T4505 T4499 arg1Of U52683,promoter
R3657 T4505 T4500 arg1Of U52683,(
R3658 T4505 T4503 arg1Of U52683,(
R3659 T4505 T4504 arg1Of U52683,GenBank
R3660 T4509 T4507 arg2Of 3A,see
R3661 T4509 T4508 arg1Of 3A,Figure
R3662 T4512 T4511 arg1Of sequences,The
R3663 T4512 T4513 arg1Of sequences,of
R3664 T4512 T4516 arg1Of sequences,were
R3665 T4512 T4517 arg1Of sequences,F1-forward
R3666 T4515 T4513 arg2Of primers,of
R3667 T4515 T4514 arg1Of primers,the
R3668 T4516 T4518 arg1Of were,:
R3669 T4517 T4516 arg2Of F1-forward,were
R3670 T4519 T4520 arg1Of 5′-TTGAGATGGAGTCTTGCTCTGT-3′,","
R3671 T4520 T4522 arg1Of ",",:
R3672 T4521 T4520 arg2Of F1-reverse,","
R3673 T4523 T4519 arg1Of ATCACTTCCAGACTTCAGTTCACCT-3′,5′-TTGAGATGGAGTCTTGCTCTGT-3′
R3674 T4523 T4521 arg1Of ATCACTTCCAGACTTCAGTTCACCT-3′,F1-reverse
R3675 T4523 T4524 arg1Of ATCACTTCCAGACTTCAGTTCACCT-3′,(
R3676 T4523 T4528 arg1Of ATCACTTCCAGACTTCAGTTCACCT-3′,;
R3677 T4526 T4524 arg2Of bp,(
R3678 T4526 T4525 arg1Of bp,341
R3679 T4527 T4524 arg3Of ),(
R3680 T4529 T4528 arg2Of F2-forward,;
R3681 T4529 T4530 arg1Of F2-forward,:
R3682 T4531 T4532 arg1Of 5′-AAGGTGAACTGAAGTCTGGAAGTGA-3′,","
R3683 T4532 T4534 arg1Of ",",:
R3684 T4533 T4532 arg2Of F2-reverse,","
R3685 T4535 T4536 arg1Of 5′-CCAGGACCTCAGGAGGCCAGTCA-3′,(
R3686 T4538 T4536 arg2Of bp,(
R3687 T4538 T4537 arg1Of bp,474
R3688 T4539 T4536 arg3Of ),(
R3689 T4542 T4540 arg1Of conditions,The
R3690 T4542 T4541 arg1Of conditions,PCR
R3691 T4542 T4543 arg1Of conditions,were
R3692 T4542 T4544 arg2Of conditions,described
R3693 T4544 T4543 arg2Of described,were
R3694 T4544 T4545 arg1Of described,elsewhere
R3695 T4545 T4546 arg1Of elsewhere,(
R3696 T4547 T4546 arg2Of 3,(
R3697 T4548 T4546 arg3Of ),(
R3698 T4549 T4550 arg1Of PCR,was
R3699 T4549 T4551 arg2Of PCR,performed
R3700 T4551 T4550 arg2Of performed,was
R3701 T4551 T4552 arg1Of performed,with
R3702 T4555 T4552 arg2Of temperature,with
R3703 T4555 T4553 arg1Of temperature,an
R3704 T4555 T4554 arg1Of temperature,annealing
R3705 T4555 T4556 arg1Of temperature,of
R3706 T4557 T4558 arg1Of 62°C,and
R3707 T4558 T4556 arg2Of and,of
R3708 T4560 T4558 arg2Of cycles,and
R3709 T4560 T4559 arg1Of cycles,35
R3710 T4562 T4563 arg1Of DNA,was
R3711 T4562 T4564 arg2Of DNA,methylated
R3712 T4564 T4561 arg2Of methylated,When
R3713 T4564 T4563 arg2Of methylated,was
R3714 T4564 T4565 arg1Of methylated,at
R3715 T4567 T4565 arg2Of sites,at
R3716 T4567 T4566 arg1Of sites,specific
R3717 T4571 T4569 arg1Of enzymes,the
R3718 T4571 T4570 arg1Of enzymes,sensitive
R3719 T4571 T4572 arg1Of enzymes,were
R3720 T4571 T4574 arg1Of enzymes,able
R3721 T4571 T4576 arg1Of enzymes,digest
R3722 T4572 T4573 arg1Of were,not
R3723 T4572 T4579 arg1Of were,and
R3724 T4574 T4572 arg2Of able,were
R3725 T4576 T4574 arg2Of digest,able
R3726 T4576 T4575 arg1Of digest,to
R3727 T4578 T4576 arg2Of DNA,digest
R3728 T4578 T4577 arg1Of DNA,the
R3729 T4579 T4561 arg1Of and,When
R3730 T4579 T4568 arg1Of and,","
R3731 T4579 T4583 arg1Of and,;
R3732 T4580 T4581 arg1Of amplification,took
R3733 T4581 T4579 arg2Of took,and
R3734 T4582 T4581 arg2Of place,took
R3735 T4585 T4584 arg2Of case,in
R3736 T4585 T4586 arg1Of case,of
R3737 T4588 T4586 arg2Of methylation,of
R3738 T4588 T4587 arg1Of methylation,no
R3739 T4590 T4591 arg1Of DNA,was
R3740 T4590 T4592 arg2Of DNA,digested
R3741 T4592 T4591 arg2Of digested,was
R3742 T4592 T4593 arg1Of digested,and
R3743 T4593 T4583 arg2Of and,;
R3744 T4593 T4584 arg1Of and,in
R3745 T4593 T4589 arg1Of and,","
R3746 T4595 T4594 arg1Of product,no
R3747 T4595 T4596 arg1Of product,was
R3748 T4595 T4597 arg2Of product,generated
R3749 T4597 T4593 arg2Of generated,and
R3750 T4597 T4596 arg2Of generated,was
R3751 T4600 T4598 arg1Of products,The
R3752 T4600 T4599 arg1Of products,PCR
R3753 T4600 T4601 arg1Of products,were
R3754 T4600 T4602 arg2Of products,electrophoresed
R3755 T4600 T4610 arg1Of products,were
R3756 T4600 T4611 arg2Of products,stained
R3757 T4600 T4616 arg2Of products,photographed
R3758 T4602 T4601 arg2Of electrophoresed,were
R3759 T4602 T4603 arg1Of electrophoresed,on
R3760 T4602 T4609 arg1Of electrophoresed,","
R3761 T4605 T4606 arg1Of 3,%
R3762 T4608 T4603 arg2Of gel,on
R3763 T4608 T4604 arg1Of gel,a
R3764 T4608 T4605 arg1Of gel,3
R3765 T4608 T4607 arg1Of gel,agarose
R3766 T4611 T4612 arg1Of stained,with
R3767 T4611 T4615 arg1Of stained,and
R3768 T4614 T4612 arg2Of bromide,with
R3769 T4614 T4613 arg1Of bromide,ethidium
R3770 T4615 T4609 arg2Of and,","
R3771 T4615 T4610 arg2Of and,were
R3772 T4616 T4615 arg2Of photographed,and
R3773 T4618 T4617 arg1Of products,PCR
R3774 T4618 T4619 arg1Of products,were
R3775 T4618 T4620 arg2Of products,verified
R3776 T4620 T4619 arg2Of verified,were
R3777 T4623 T4620 arg1Of sequencing,verified
R3778 T4623 T4621 arg2Of sequencing,by
R3779 T4623 T4622 arg2Of sequencing,automated
R4058 T4944 T4943 arg1Of treatment,Bisulfite
R4059 T4945 T4946 arg1Of DNA,was
R4060 T4945 T4947 arg2Of DNA,extracted
R4061 T4947 T4946 arg2Of extracted,was
R4062 T4947 T4948 arg1Of extracted,as
R4063 T4949 T4948 arg2Of described,as
R4064 T4949 T4950 arg1Of described,above
R4065 T4952 T4951 arg1Of treatment,Bisulfite
R4066 T4952 T4953 arg1Of treatment,of
R4067 T4952 T4955 arg1Of treatment,","
R4068 T4952 T4956 arg1Of treatment,leading
R4069 T4952 T4962 modOf treatment,to
R4070 T4952 T4978 arg1Of treatment,follows
R4071 T4954 T4953 arg2Of DNA,of
R4072 T4956 T4957 arg1Of leading,to
R4073 T4958 T4957 arg2Of conversion,to
R4074 T4958 T4959 arg1Of conversion,of
R4075 T4961 T4959 arg2Of cytosine,of
R4076 T4961 T4960 arg1Of cytosine,unmethylated
R4077 T4963 T4972 arg1Of uracil,","
R4078 T4964 T4965 arg1Of residues,and
R4079 T4965 T4963 arg2Of and,uracil
R4080 T4967 T4965 arg2Of change,and
R4081 T4967 T4966 arg1Of change,no
R4082 T4967 T4968 arg1Of change,of
R4083 T4971 T4968 arg2Of residues,of
R4084 T4971 T4969 arg2Of residues,methylated
R4085 T4971 T4970 arg1Of residues,cytosine
R4086 T4972 T4962 arg1Of ",",to
R4087 T4974 T4972 arg2Of performed,","
R4088 T4974 T4973 arg2Of performed,was
R4089 T4974 T4975 arg1Of performed,as
R4090 T4976 T4975 arg2Of described,as
R4091 T4976 T4977 arg1Of described,as
R4092 T4982 T4981 arg1Of µg,1
R4093 T4982 T4983 arg1Of µg,of
R4094 T4982 T4988 arg1Of µg,of
R4095 T4982 T5004 arg1Of µg,were
R4096 T4982 T5005 arg2Of µg,denaturated
R4097 T4984 T4985 arg1Of DNA,and
R4098 T4985 T4983 arg2Of and,of
R4099 T4987 T4985 arg2Of µg,and
R4100 T4987 T4986 arg1Of µg,2
R4101 T4989 T4990 arg1Of poly,(
R4102 T4991 T4990 arg2Of dA–dT,(
R4103 T4992 T4990 arg3Of ),(
R4104 T4996 T4995 arg2Of dA–dT,(
R4105 T4997 T4995 arg3Of ),(
R4106 T4998 T4988 arg2Of copolymers,of
R4107 T4998 T4989 arg1Of copolymers,poly
R4108 T4998 T4993 arg1Of copolymers,(
R4109 T4998 T4994 arg1Of copolymers,poly
R4110 T4998 T4995 arg1Of copolymers,(
R4111 T4998 T4999 arg1Of copolymers,(
R4112 T5002 T4999 arg2Of Biotech,(
R4113 T5002 T5000 arg1Of Biotech,Amersham
R4114 T5002 T5001 arg1Of Biotech,Pharmacia
R4115 T5003 T4999 arg3Of ),(
R4116 T5005 T4979 arg1Of denaturated,Briefly
R4117 T5005 T4980 arg1Of denaturated,","
R4118 T5005 T5004 arg2Of denaturated,were
R4119 T5005 T5006 arg1Of denaturated,for
R4120 T5005 T5009 arg1Of denaturated,at
R4121 T5005 T5011 arg1Of denaturated,in
R4122 T5005 T5015 arg1Of denaturated,in
R4123 T5008 T5006 arg2Of min,for
R4124 T5008 T5007 arg1Of min,20
R4125 T5010 T5009 arg2Of 42°C,at
R4126 T5012 T5013 arg1Of 0.3,M
R4127 T5014 T5011 arg2Of NaOH,in
R4128 T5014 T5012 arg1Of NaOH,0.3
R4129 T5017 T5015 arg2Of volume,in
R4130 T5017 T5016 arg1Of volume,a
R4131 T5017 T5018 arg1Of volume,of
R4132 T5020 T5018 arg2Of µl,of
R4133 T5020 T5019 arg1Of µl,50
R4134 T5022 T5021 arg1Of solutions,Fresh
R4135 T5022 T5023 arg1Of solutions,of
R4136 T5022 T5047 arg1Of solutions,were
R4137 T5022 T5048 arg2Of solutions,added
R4138 T5025 T5024 arg1Of µl,30
R4139 T5025 T5026 arg1Of µl,of
R4140 T5025 T5033 arg1Of µl,and
R4141 T5027 T5028 arg1Of 10,mM
R4142 T5029 T5026 arg2Of hydrochinon,of
R4143 T5029 T5027 arg1Of hydrochinon,10
R4144 T5029 T5030 arg1Of hydrochinon,(
R4145 T5031 T5030 arg2Of Sigma,(
R4146 T5032 T5030 arg3Of ),(
R4147 T5033 T5023 arg2Of and,of
R4148 T5035 T5033 arg2Of µl,and
R4149 T5035 T5034 arg1Of µl,530
R4150 T5035 T5036 arg1Of µl,of
R4151 T5037 T5038 arg1Of 3,M
R4152 T5040 T5036 arg2Of bisulfite,of
R4153 T5040 T5037 arg1Of bisulfite,3
R4154 T5040 T5039 arg1Of bisulfite,sodium
R4155 T5040 T5041 arg1Of bisulfite,(
R4156 T5042 T5041 arg2Of pH,(
R4157 T5042 T5043 arg1Of pH,5.0
R4158 T5042 T5044 arg1Of pH,;
R4159 T5045 T5044 arg2Of Sigma,;
R4160 T5046 T5041 arg3Of ),(
R4161 T5048 T5047 arg2Of added,were
R4162 T5051 T5050 arg1Of solution,the
R4163 T5051 T5052 arg1Of solution,was
R4164 T5051 T5054 arg2Of solution,mixed
R4165 T5051 T5056 arg2Of solution,overlayed
R4166 T5051 T5061 arg2Of solution,incubated
R4167 T5054 T5055 arg1Of mixed,","
R4168 T5055 T5060 arg1Of ",",and
R4169 T5056 T5055 arg2Of overlayed,","
R4170 T5056 T5057 arg1Of overlayed,with
R4171 T5059 T5057 arg2Of oil,with
R4172 T5059 T5058 arg1Of oil,mineral
R4173 T5060 T5049 arg1Of and,","
R4174 T5060 T5052 arg2Of and,was
R4175 T5060 T5053 arg1Of and,gently
R4176 T5061 T5060 arg2Of incubated,and
R4177 T5061 T5062 arg1Of incubated,in
R4178 T5064 T5062 arg2Of dark,in
R4179 T5064 T5063 arg1Of dark,the
R4180 T5067 T5066 arg1Of h,12–13
R4181 T5067 T5068 arg1Of h,at
R4182 T5067 T5073 arg1Of h,was
R4183 T5067 T5074 arg2Of h,recovered
R4184 T5072 T5068 arg2Of phase,at
R4185 T5072 T5069 arg1Of phase,50°C.
R4186 T5072 T5070 arg1Of phase,The
R4187 T5072 T5071 arg1Of phase,aqueous
R4188 T5074 T5073 arg2Of recovered,was
R4189 T5074 T5075 modOf recovered,using
R4190 T5074 T5081 arg1Of recovered,(
R4191 T5080 T5075 arg2Of system’,using
R4192 T5080 T5076 arg1Of system’,the
R4193 T5080 T5077 arg1Of system’,‘Wizard
R4194 T5080 T5078 arg1Of system’,DNA
R4195 T5080 T5079 arg1Of system’,clean-up
R4196 T5082 T5083 arg1Of Promega,","
R4197 T5083 T5081 arg2Of ",",(
R4198 T5083 T5085 arg1Of ",",","
R4199 T5084 T5083 arg2Of Mannheim,","
R4200 T5086 T5085 arg2Of Germany,","
R4201 T5087 T5081 arg3Of ),(
R4202 T5090 T5088 arg1Of DNA,The
R4203 T5090 T5089 arg2Of DNA,purified
R4204 T5090 T5091 arg1Of DNA,was
R4205 T5090 T5093 arg2Of DNA,mixed
R4206 T5090 T5106 arg2Of DNA,incubated
R4207 T5093 T5094 arg1Of mixed,with
R4208 T5093 T5105 arg1Of mixed,and
R4209 T5095 T5096 arg1Of 1,M
R4210 T5097 T5094 arg2Of NaOH,with
R4211 T5097 T5095 arg1Of NaOH,1
R4212 T5097 T5098 arg1Of NaOH,to
R4213 T5101 T5098 arg2Of concentration,to
R4214 T5101 T5099 arg1Of concentration,a
R4215 T5101 T5100 arg1Of concentration,final
R4216 T5101 T5102 arg1Of concentration,of
R4217 T5104 T5102 arg2Of M,of
R4218 T5104 T5103 arg1Of M,0.3
R4219 T5105 T5091 arg2Of and,was
R4220 T5105 T5092 arg1Of and,subsequently
R4221 T5106 T5105 arg2Of incubated,and
R4222 T5106 T5107 arg1Of incubated,for
R4223 T5106 T5110 arg1Of incubated,at
R4224 T5106 T5112 modOf incubated,to
R4225 T5109 T5107 arg2Of min,for
R4226 T5109 T5108 arg1Of min,20
R4227 T5111 T5110 arg2Of 37°C,at
R4228 T5113 T5112 arg1Of ensure,to
R4229 T5115 T5113 arg2Of desulfonisation,ensure
R4230 T5115 T5114 arg1Of desulfonisation,complete
R4231 T5116 T5117 arg1Of DNA,was
R4232 T5116 T5138 arg1Of DNA,resuspended
R4233 T5117 T5137 arg1Of was,and
R4234 T5118 T5117 arg2Of ethanol,was
R4235 T5118 T5119 arg2Of ethanol,precipitated
R4236 T5119 T5120 arg1Of precipitated,in
R4237 T5122 T5120 arg2Of presence,in
R4238 T5122 T5121 arg1Of presence,the
R4239 T5122 T5123 arg1Of presence,of
R4240 T5122 T5131 arg1Of presence,","
R4241 T5122 T5132 arg2Of presence,washed
R4242 T5125 T5123 arg2Of vol,of
R4243 T5125 T5124 arg1Of vol,1/10
R4244 T5125 T5126 arg1Of vol,of
R4245 T5127 T5128 arg1Of 3,M
R4246 T5130 T5126 arg2Of acetate,of
R4247 T5130 T5127 arg1Of acetate,3
R4248 T5130 T5129 arg1Of acetate,sodium
R4249 T5132 T5133 arg1Of washed,with
R4250 T5134 T5135 arg1Of 70,%
R4251 T5136 T5133 arg2Of ethanol,with
R4252 T5136 T5134 arg1Of ethanol,70
R4253 T5138 T5137 arg2Of resuspended,and
R4254 T5138 T5139 arg1Of resuspended,in
R4255 T5142 T5139 arg2Of H2O,in
R4256 T5142 T5140 arg1Of H2O,50
R4257 T5142 T5141 arg1Of H2O,µl
R4258 T5145 T5143 arg1Of amplification,Subsequent
R4259 T5145 T5144 arg1Of amplification,PCR
R4260 T5145 T5146 arg1Of amplification,of
R4261 T5145 T5151 arg1Of amplification,was
R4262 T5145 T5152 arg2Of amplification,used
R4263 T5150 T5146 arg2Of DNA,of
R4264 T5150 T5147 arg1Of DNA,4
R4265 T5150 T5148 arg1Of DNA,µl
R4266 T5150 T5149 arg1Of DNA,bisulfite-treated
R4267 T5152 T5151 arg2Of used,was
R4268 T5152 T5153 arg1Of used,for
R4269 T5152 T5167 arg1Of used,into
R4270 T5152 T5179 arg1Of used,(
R4271 T5154 T5153 arg2Of cloning,for
R4272 T5154 T5155 arg1Of cloning,of
R4273 T5157 T5155 arg2Of fragments,of
R4274 T5157 T5156 arg1Of fragments,two
R4275 T5157 T5158 arg1Of fragments,of
R4276 T5157 T5162 arg1Of fragments,(
R4277 T5161 T5158 arg2Of promoter,of
R4278 T5161 T5159 arg1Of promoter,the
R4279 T5161 T5160 arg1Of promoter,IRF-4
R4280 T5163 T5164 arg1Of BS-I,and
R4281 T5164 T5162 arg2Of and,(
R4282 T5165 T5164 arg2Of BS-II,and
R4283 T5166 T5162 arg3Of ),(
R4284 T5169 T5167 arg2Of vector,into
R4285 T5169 T5168 arg1Of vector,pCR2.1
R4286 T5169 T5170 arg1Of vector,with
R4287 T5175 T5170 arg2Of kit’,with
R4288 T5175 T5171 arg1Of kit’,the
R4289 T5175 T5172 arg1Of kit’,‘TOPO
R4290 T5175 T5173 arg1Of kit’,TA
R4291 T5175 T5174 arg1Of kit’,cloning
R4292 T5175 T5176 arg1Of kit’,(
R4293 T5177 T5176 arg2Of Invitrogen,(
R4294 T5178 T5176 arg3Of ),(
R4295 T5180 T5179 arg2Of see,(
R4296 T5182 T5180 arg2Of 3A,see
R4297 T5182 T5181 arg1Of 3A,Figure
R4298 T5183 T5179 arg3Of ),(
R4299 T5185 T5184 arg1Of primers,The
R4300 T5185 T5186 arg2Of primers,used
R4301 T5185 T5196 arg1Of primers,contain
R4302 T5186 T5187 arg1Of used,for
R4303 T5189 T5187 arg2Of amplification,for
R4304 T5189 T5188 arg1Of amplification,PCR
R4305 T5189 T5190 arg1Of amplification,of
R4306 T5192 T5193 arg1Of BS-I,and
R4307 T5194 T5193 arg2Of BS-II,and
R4308 T5195 T5190 arg2Of fragments,of
R4309 T5195 T5191 arg1Of fragments,the
R4310 T5195 T5192 arg1Of fragments,BS-I
R4311 T5195 T5194 arg1Of fragments,BS-II
R4312 T5196 T5219 arg1Of contain,:
R4313 T5196 T5221 arg1Of contain,5′-TATTTGGATTTTTAGGGAGTTTTTTTT-3′
R4314 T5196 T5229 arg1Of contain,;
R4315 T5196 T5231 arg1Of contain,5′-AGTTTAATAGTTTAAGGGAGTTGGGT-3′
R4316 T5200 T5196 arg2Of sequence,contain
R4317 T5200 T5197 arg1Of sequence,the
R4318 T5200 T5198 arg1Of sequence,putative
R4319 T5200 T5199 arg1Of sequence,altered
R4320 T5200 T5201 arg1Of sequence,of
R4321 T5204 T5201 arg2Of strand,of
R4322 T5204 T5202 arg1Of strand,the
R4323 T5204 T5203 arg1Of strand,sense
R4324 T5204 T5205 arg1Of strand,due
R4325 T5207 T5205 arg2Of bisulfite,due
R4326 T5207 T5206 arg1Of bisulfite,to
R4327 T5208 T5207 arg2Of treatment,bisulfite
R4328 T5208 T5209 arg1Of treatment,(
R4329 T5212 T5210 arg2Of residues,converted
R4330 T5212 T5211 arg1Of residues,cytosine
R4331 T5212 T5213 arg1Of residues,are
R4332 T5212 T5214 arg2Of residues,written
R4333 T5214 T5209 arg2Of written,(
R4334 T5214 T5213 arg2Of written,are
R4335 T5214 T5215 arg1Of written,in
R4336 T5217 T5215 arg2Of letters,in
R4337 T5217 T5216 arg1Of letters,bold
R4338 T5218 T5209 arg3Of ),(
R4339 T5221 T5220 arg1Of 5′-TATTTGGATTTTTAGGGAGTTTTTTTT-3′,BS-I-forward
R4340 T5221 T5222 arg1Of 5′-TATTTGGATTTTTAGGGAGTTTTTTTT-3′,","
R4341 T5224 T5222 arg2Of 5′-ACCCAACTCCCTTAAACTATTAAACT-3′,","
R4342 T5224 T5223 arg1Of 5′-ACCCAACTCCCTTAAACTATTAAACT-3′,BS-I-reverse
R4343 T5224 T5225 arg1Of 5′-ACCCAACTCCCTTAAACTATTAAACT-3′,(
R4344 T5227 T5225 arg2Of bp,(
R4345 T5227 T5226 arg1Of bp,187
R4346 T5228 T5225 arg3Of ),(
R4347 T5231 T5230 arg1Of 5′-AGTTTAATAGTTTAAGGGAGTTGGGT-3′,BS-II-forward
R4348 T5231 T5232 arg1Of 5′-AGTTTAATAGTTTAAGGGAGTTGGGT-3′,","
R4349 T5234 T5232 arg2Of 5′-CTCACCCTAAACTCAAAACTAAAAAC-3′,","
R4350 T5234 T5233 arg1Of 5′-CTCACCCTAAACTCAAAACTAAAAAC-3′,BS-II-reverse
R4351 T5234 T5235 arg1Of 5′-CTCACCCTAAACTCAAAACTAAAAAC-3′,(
R4352 T5237 T5235 arg2Of bp,(
R4353 T5237 T5236 arg1Of bp,674
R4354 T5238 T5235 arg3Of ),(
R4355 T5241 T5239 arg2Of amplification,After
R4356 T5241 T5240 arg1Of amplification,bacterial
R4357 T5241 T5242 arg1Of amplification,of
R4358 T5241 T5247 arg1Of amplification,by
R4359 T5246 T5242 arg2Of fragments,of
R4360 T5246 T5243 arg1Of fragments,the
R4361 T5246 T5244 arg2Of fragments,cloned
R4362 T5246 T5245 arg1Of fragments,PCR
R4363 T5249 T5247 arg2Of procedures,by
R4364 T5249 T5248 arg1Of procedures,standard
R4365 T5252 T5251 arg1Of clones,eight
R4366 T5252 T5253 arg1Of clones,from
R4367 T5252 T5256 arg1Of clones,were
R4368 T5252 T5257 arg2Of clones,sequenced
R4369 T5255 T5253 arg2Of sample,from
R4370 T5255 T5254 arg1Of sample,each
R4371 T5257 T5239 arg1Of sequenced,After
R4372 T5257 T5250 arg1Of sequenced,","
R4373 T5257 T5256 arg2Of sequenced,were
R4374 T5257 T5258 arg1Of sequenced,with
R4375 T5257 T5262 arg1Of sequenced,(
R4376 T5261 T5258 arg2Of sequencer,with
R4377 T5261 T5259 arg1Of sequencer,an
R4378 T5261 T5260 arg2Of sequencer,automated
R4379 T5264 T5262 arg2Of Prism,(
R4380 T5264 T5263 arg1Of Prism,ABI
R4381 T5264 T5265 arg1Of Prism,377
R4382 T5264 T5266 arg1Of Prism,","
R4383 T5268 T5266 arg2Of Biosystems,","
R4384 T5268 T5267 arg1Of Biosystems,Applied
R4385 T5269 T5262 arg3Of ),(
R4762 T5702 T5701 arg1Of vitro,In
R4763 T5703 T5704 arg1Of methylation,and
R4764 T5705 T5704 arg2Of reporter,and
R4765 T5707 T5702 arg1Of assays,vitro
R4766 T5707 T5703 arg1Of assays,methylation
R4767 T5707 T5705 arg1Of assays,reporter
R4768 T5707 T5706 arg1Of assays,gene
R4769 T5712 T5708 arg1Of construct,The
R4770 T5712 T5709 arg1Of construct,IRF-4
R4771 T5712 T5710 arg1Of construct,promoter-reporter
R4772 T5712 T5711 arg1Of construct,gene
R4773 T5712 T5713 arg1Of construct,was
R4774 T5712 T5715 arg2Of construct,provided
R4775 T5715 T5713 arg2Of provided,was
R4776 T5715 T5714 arg1Of provided,generously
R4777 T5718 T5715 arg1Of Hiscott,provided
R4778 T5718 T5716 arg2Of Hiscott,by
R4779 T5718 T5717 arg1Of Hiscott,J.
R4780 T5718 T5719 arg1Of Hiscott,(
R4781 T5720 T5719 arg2Of 31,(
R4782 T5721 T5719 arg3Of ),(
R4783 T5722 T5723 arg1Of Constructs,were
R4784 T5722 T5724 arg2Of Constructs,methylated
R4785 T5724 T5723 arg2Of methylated,were
R4786 T5724 T5726 arg1Of methylated,vitro
R4787 T5724 T5727 arg1Of methylated,with
R4788 T5724 T5734 arg1Of methylated,as
R4789 T5724 T5743 arg1Of methylated,and
R4790 T5726 T5725 arg1Of vitro,in
R4791 T5729 T5727 arg2Of Methylase,with
R4792 T5729 T5728 arg1Of Methylase,CpG
R4793 T5729 T5730 arg1Of Methylase,(
R4794 T5731 T5730 arg2Of M.Sss,(
R4795 T5731 T5732 arg1Of M.Sss,I
R4796 T5733 T5730 arg3Of ),(
R4797 T5735 T5734 arg2Of recommended,as
R4798 T5738 T5735 arg1Of manufacturer,recommended
R4799 T5738 T5736 arg2Of manufacturer,by
R4800 T5738 T5737 arg1Of manufacturer,the
R4801 T5738 T5739 arg1Of manufacturer,(
R4802 T5741 T5739 arg2Of Biolabs,(
R4803 T5741 T5740 arg1Of Biolabs,NE
R4804 T5742 T5739 arg3Of ),(
R4805 T5745 T5744 arg1Of methylation,complete
R4806 T5745 T5746 arg1Of methylation,was
R4807 T5745 T5747 arg2Of methylation,checked
R4808 T5747 T5743 arg2Of checked,and
R4809 T5747 T5746 arg2Of checked,was
R4810 T5747 T5748 arg1Of checked,via
R4811 T5750 T5748 arg2Of analysis,via
R4812 T5750 T5749 arg1Of analysis,restriction
R4813 T5750 T5751 arg1Of analysis,(
R4814 T5753 T5751 arg2Of 5A,(
R4815 T5753 T5752 arg1Of 5A,Figure
R4816 T5754 T5751 arg3Of ),(
R4817 T5756 T5755 arg1Of gene,Reporter
R4818 T5756 T5766 modOf gene,were
R4819 T5756 T5768 arg1Of gene,similar
R4820 T5757 T5758 arg1Of assays,using
R4821 T5757 T5766 arg1Of assays,were
R4822 T5757 T5767 arg2Of assays,performed
R4823 T5762 T5758 arg2Of assay,using
R4824 T5762 T5759 arg1Of assay,the
R4825 T5762 T5760 arg1Of assay,dual
R4826 T5762 T5761 arg1Of assay,luciferase
R4827 T5762 T5763 arg1Of assay,(
R4828 T5764 T5763 arg2Of Promega,(
R4829 T5765 T5763 arg3Of ),(
R4830 T5767 T5766 arg2Of performed,were
R4831 T5768 T5769 arg1Of similar,to
R4832 T5771 T5756 arg1Of reports,gene
R4833 T5771 T5770 arg1Of reports,previous
R4834 T5771 T5772 arg1Of reports,(
R4835 T5773 T5772 arg2Of 29,(
R4836 T5774 T5772 arg3Of ),(
R4837 T5778 T5777 arg1Of nM,5
R4838 T5778 T5779 arg1Of nM,of
R4839 T5778 T5783 arg1Of nM,and
R4840 T5782 T5779 arg2Of construct,of
R4841 T5782 T5780 arg1Of construct,the
R4842 T5782 T5781 arg1Of construct,reporter
R4843 T5783 T5793 arg1Of and,were
R4844 T5783 T5794 arg2Of and,transientlyco-expressed
R4845 T5787 T5783 arg2Of construct,and
R4846 T5787 T5784 arg1Of construct,the
R4847 T5787 T5785 arg1Of construct,transfection
R4848 T5787 T5786 arg1Of construct,control
R4849 T5787 T5788 arg1Of construct,expressing
R4850 T5792 T5788 arg2Of gene,expressing
R4851 T5792 T5789 arg1Of gene,the
R4852 T5792 T5790 arg1Of gene,renilla
R4853 T5792 T5791 arg1Of gene,luciferase
R4854 T5794 T5775 arg1Of transientlyco-expressed,Briefly
R4855 T5794 T5776 arg1Of transientlyco-expressed,","
R4856 T5794 T5793 arg2Of transientlyco-expressed,were
R4857 T5794 T5795 arg1Of transientlyco-expressed,via
R4858 T5796 T5795 arg2Of electroporation,via
R4859 T5799 T5797 arg1Of construct,The
R4860 T5799 T5798 arg1Of construct,control
R4861 T5799 T5800 arg1Of construct,served
R4862 T5800 T5801 arg1Of served,as
R4863 T5804 T5801 arg2Of reference,as
R4864 T5804 T5802 arg1Of reference,an
R4865 T5804 T5803 arg1Of reference,internal
R4866 T5804 T5805 arg1Of reference,for
R4867 T5807 T5805 arg2Of efficiency,for
R4868 T5807 T5806 arg1Of efficiency,transfection
R4869 T5809 T5808 arg1Of hours,Forty-eight
R4870 T5810 T5809 arg1Of after,hours
R4871 T5811 T5810 arg2Of transfection,after
R4872 T5814 T5813 arg1Of activity,luciferase
R4873 T5814 T5815 arg1Of activity,was
R4874 T5814 T5816 arg2Of activity,measured
R4875 T5816 T5810 arg1Of measured,after
R4876 T5816 T5812 arg1Of measured,","
R4877 T5816 T5815 arg2Of measured,was
R4878 T5816 T5817 arg1Of measured,with
R4879 T5816 T5823 arg1Of measured,(
R4880 T5822 T5817 arg2Of microlumat,with
R4881 T5822 T5818 arg1Of microlumat,a
R4882 T5822 T5819 arg1Of microlumat,LB
R4883 T5822 T5820 arg1Of microlumat,96
R4884 T5822 T5821 arg1Of microlumat,P
R4885 T5827 T5823 arg2Of Berthold,(
R4886 T5827 T5824 arg1Of Berthold,EG
R4887 T5827 T5825 arg1Of Berthold,&
R4888 T5827 T5826 arg1Of Berthold,G
R4889 T5827 T5828 arg1Of Berthold,","
R4890 T5830 T5828 arg2Of Wildbad,","
R4891 T5830 T5829 arg1Of Wildbad,Bad
R4892 T5830 T5831 arg1Of Wildbad,","
R4893 T5832 T5831 arg2Of Germany,","
R4894 T5833 T5823 arg3Of ),(
R4895 T5836 T5834 arg1Of activation,IRF-4
R4896 T5836 T5835 arg1Of activation,promoter
R4897 T5836 T5837 arg1Of activation,was
R4898 T5836 T5838 arg2Of activation,quantified
R4899 T5838 T5837 arg2Of quantified,was
R4900 T5838 T5839 arg1Of quantified,as
R4901 T5841 T5839 arg2Of ratio,as
R4902 T5841 T5840 arg1Of ratio,a
R4903 T5841 T5842 arg1Of ratio,of
R4904 T5845 T5844 arg1Of light,firefly
R4905 T5846 T5842 arg2Of units,of
R4906 T5846 T5843 arg2Of units,measured
R4907 T5846 T5845 arg1Of units,light
R4908 T5846 T5847 arg1Of units,(
R4909 T5846 T5850 arg1Of units,relative
R4910 T5848 T5847 arg2Of flu,(
R4911 T5849 T5847 arg3Of ),(
R4912 T5850 T5851 arg1Of relative,to
R4913 T5852 T5851 arg2Of renilla,to
R4914 T5852 T5853 arg1Of renilla,(
R4915 T5854 T5853 arg2Of rlu,(
R4916 T5855 T5853 arg3Of ),(
R4917 T5857 T5856 arg1Of experiment,Each
R4918 T5857 T5858 arg1Of experiment,was
R4919 T5857 T5859 arg2Of experiment,carried
R4920 T5859 T5858 arg2Of carried,was
R4921 T5859 T5860 arg1Of carried,out
R4922 T5859 T5864 arg1Of carried,times
R4923 T5863 T5861 arg1Of three,at
R4924 T5863 T5862 arg1Of three,least
R4925 T5864 T5863 arg1Of times,three
R5176 T6221 T6222 arg1Of Absence,of
R5177 T6221 T6228 arg1Of Absence,is
R5178 T6221 T6230 arg1Of Absence,due
R5179 T6224 T6222 arg2Of expression,of
R5180 T6224 T6223 arg1Of expression,IRF-4
R5181 T6224 T6225 arg1Of expression,in
R5182 T6227 T6225 arg2Of cells,in
R5183 T6227 T6226 arg1Of cells,leukemia
R5184 T6228 T6229 arg1Of is,not
R5185 T6230 T6228 arg2Of due,is
R5186 T6230 T6231 arg1Of due,to
R5187 T6233 T6231 arg2Of alterations,to
R5188 T6233 T6232 arg1Of alterations,promoter
R5189 T6234 T6235 arg1Of We,have
R5190 T6234 T6237 arg1Of We,demonstrated
R5191 T6237 T6235 arg2Of demonstrated,have
R5192 T6237 T6236 arg1Of demonstrated,previously
R5193 T6239 T6237 arg2Of lack,demonstrated
R5194 T6239 T6238 arg1Of lack,a
R5195 T6239 T6240 arg1Of lack,of
R5196 T6239 T6243 arg1Of lack,in
R5197 T6239 T6248 arg1Of lack,in
R5198 T6242 T6240 arg2Of expression,of
R5199 T6242 T6241 arg1Of expression,IRF-4
R5200 T6243 T6246 arg1Of in,and
R5201 T6245 T6243 arg2Of patients,in
R5202 T6245 T6244 arg1Of patients,leukemia
R5203 T6248 T6246 arg2Of in,and
R5204 T6248 T6247 arg1Of in,specifically
R5205 T6250 T6248 arg2Of T-cells,in
R5206 T6250 T6249 arg1Of T-cells,CML
R5207 T6250 T6251 arg1Of T-cells,(
R5208 T6252 T6251 arg2Of 3,(
R5209 T6253 T6251 arg3Of ),(
R5210 T6256 T6257 arg1Of we,demonstrate
R5211 T6257 T6254 arg1Of demonstrate,Here
R5212 T6257 T6255 arg1Of demonstrate,","
R5213 T6259 T6258 arg1Of absence,the
R5214 T6259 T6260 arg1Of absence,of
R5215 T6259 T6306 arg1Of absence,in
R5216 T6259 T6318 arg1Of absence,","
R5217 T6259 T6324 arg1Of absence,and
R5218 T6260 T6304 arg1Of of,but
R5219 T6262 T6260 arg2Of expression,of
R5220 T6262 T6261 arg1Of expression,IRF-4
R5221 T6262 T6263 arg1Of expression,in
R5222 T6262 T6278 arg1Of expression,","
R5223 T6262 T6289 arg1Of expression,","
R5224 T6262 T6291 arg1Of expression,","
R5225 T6267 T6263 arg2Of lines,in
R5226 T6267 T6264 arg1Of lines,various
R5227 T6267 T6265 arg1Of lines,hematopoietic
R5228 T6267 T6266 arg1Of lines,cell
R5229 T6267 T6268 arg1Of lines,","
R5230 T6267 T6270 arg1Of lines,as
R5231 T6270 T6269 arg1Of as,such
R5232 T6271 T6270 arg2Of Jurkat,as
R5233 T6271 T6272 arg1Of Jurkat,","
R5234 T6271 T6276 arg1Of Jurkat,","
R5235 T6275 T6272 arg2Of leukemia,","
R5236 T6275 T6273 arg1Of leukemia,a
R5237 T6275 T6274 arg1Of leukemia,T-cell
R5238 T6277 T6276 arg2Of CML-T1,","
R5239 T6282 T6278 arg2Of line,","
R5240 T6282 T6279 arg1Of line,a
R5241 T6282 T6280 arg1Of line,bcr-abl-positive
R5242 T6282 T6281 arg1Of line,T-cell
R5243 T6282 T6283 arg1Of line,","
R5244 T6282 T6285 arg1Of line,","
R5245 T6284 T6283 arg2Of K-562,","
R5246 T6288 T6285 arg2Of erythroleukemia,","
R5247 T6288 T6286 arg1Of erythroleukemia,a
R5248 T6288 T6287 arg1Of erythroleukemia,bcr-abl-positve
R5249 T6290 T6289 arg2Of U-937,","
R5250 T6294 T6295 arg1Of leukemia,","
R5251 T6295 T6297 arg1Of ",",and
R5252 T6296 T6295 arg2Of EM-2,","
R5253 T6297 T6293 arg1Of and,monocytic
R5254 T6297 T6299 arg1Of and,","
R5255 T6298 T6297 arg2Of LAMA-84,and
R5256 T6299 T6291 arg2Of ",",","
R5257 T6299 T6292 arg1Of ",",a
R5258 T6302 T6299 arg2Of leukemia,","
R5259 T6302 T6300 arg1Of leukemia,bcr-abl-positve
R5260 T6302 T6301 arg1Of leukemia,myeloid
R5261 T6304 T6303 arg1Of but,","
R5262 T6306 T6304 arg2Of in,but
R5263 T6306 T6305 arg1Of in,not
R5264 T6307 T6306 arg2Of SD-1,in
R5265 T6307 T6308 arg1Of SD-1,","
R5266 T6313 T6308 arg2Of leukemia,","
R5267 T6313 T6309 arg1Of leukemia,a
R5268 T6313 T6310 arg1Of leukemia,bcr-abl-positive
R5269 T6313 T6311 arg1Of leukemia,acute
R5270 T6313 T6312 arg1Of leukemia,lymphoblastic
R5271 T6313 T6314 arg1Of leukemia,(
R5272 T6316 T6314 arg2Of B-ALL,(
R5273 T6316 T6315 arg1Of B-ALL,pre
R5274 T6317 T6314 arg3Of ),(
R5275 T6319 T6318 arg2Of RPMI-8226,","
R5276 T6319 T6320 arg1Of RPMI-8226,","
R5277 T6323 T6320 arg2Of myeloma,","
R5278 T6323 T6321 arg1Of myeloma,a
R5279 T6323 T6322 arg1Of myeloma,multiple
R5280 T6324 T6257 arg2Of and,demonstrate
R5281 T6325 T6324 arg2Of BV-173,and
R5282 T6325 T6326 arg1Of BV-173,","
R5283 T6330 T6326 arg2Of line,","
R5284 T6330 T6327 arg1Of line,a
R5285 T6330 T6328 arg1Of line,bcr-abl-positive
R5286 T6330 T6329 arg1Of line,B-cell
R5287 T6330 T6331 arg1Of line,(
R5288 T6333 T6334 arg1Of 1A,and
R5289 T6334 T6331 arg2Of and,(
R5290 T6334 T6332 arg1Of and,Figures
R5291 T6335 T6334 arg2Of 5D,and
R5292 T6336 T6331 arg3Of ),(
R5293 T6338 T6337 arg2Of sequencing,After
R5294 T6338 T6339 arg1Of sequencing,of
R5295 T6342 T6339 arg2Of promoter,of
R5296 T6342 T6340 arg1Of promoter,the
R5297 T6342 T6341 arg1Of promoter,IRF-4
R5298 T6344 T6345 arg1Of it,could
R5299 T6344 T6346 arg1Of it,be
R5300 T6346 T6337 arg1Of be,After
R5301 T6346 T6343 arg1Of be,","
R5302 T6346 T6345 arg2Of be,could
R5303 T6346 T6353 arg1Of be,in
R5304 T6349 T6346 arg2Of absence,be
R5305 T6349 T6347 arg2Of absence,excluded
R5306 T6349 T6348 arg1Of absence,that
R5307 T6349 T6350 arg1Of absence,of
R5308 T6352 T6350 arg2Of expression,of
R5309 T6352 T6351 arg1Of expression,IRF-4
R5310 T6354 T6355 arg1Of any,of
R5311 T6354 T6360 arg1Of any,was
R5312 T6354 T6361 arg1Of any,due
R5313 T6359 T6355 arg2Of lines,of
R5314 T6359 T6356 arg1Of lines,the
R5315 T6359 T6357 arg1Of lines,above
R5316 T6359 T6358 arg1Of lines,cell
R5317 T6360 T6353 arg2Of was,in
R5318 T6361 T6360 arg2Of due,was
R5319 T6361 T6362 arg1Of due,to
R5320 T6364 T6362 arg2Of aberrations,to
R5321 T6364 T6363 arg1Of aberrations,genetic
R5322 T6369 T6367 arg1Of changes,2
R5323 T6369 T6368 arg1Of changes,bp
R5324 T6369 T6370 arg1Of changes,(
R5325 T6369 T6380 arg1Of changes,could
R5326 T6369 T6381 arg1Of changes,be
R5327 T6369 T6382 arg2Of changes,detected
R5328 T6372 T6371 arg1Of −1081,nucleotide
R5329 T6372 T6373 arg1Of −1081,","
R5330 T6373 T6375 arg1Of ",",and
R5331 T6374 T6373 arg2Of T→C,","
R5332 T6375 T6370 arg2Of and,(
R5333 T6375 T6377 arg1Of and,","
R5334 T6376 T6375 arg2Of −1068,and
R5335 T6378 T6377 arg2Of A→C,","
R5336 T6379 T6370 arg3Of ),(
R5337 T6382 T6365 arg1Of detected,However
R5338 T6382 T6366 arg1Of detected,","
R5339 T6382 T6380 arg2Of detected,could
R5340 T6382 T6381 arg2Of detected,be
R5341 T6382 T6383 arg1Of detected,in
R5342 T6387 T6385 arg1Of BV-173,the
R5343 T6387 T6386 arg1Of BV-173,IRF-4-positive
R5344 T6387 T6388 arg1Of BV-173,and
R5345 T6388 T6383 arg2Of and,in
R5346 T6388 T6384 arg1Of and,both
R5347 T6388 T6392 arg1Of and,","
R5348 T6391 T6388 arg2Of LAMA-84,and
R5349 T6391 T6389 arg1Of LAMA-84,the
R5350 T6391 T6390 arg1Of LAMA-84,IRF-4-negative
R5351 T6393 T6394 arg1Of EM-2,and
R5352 T6394 T6392 arg2Of and,","
R5353 T6394 T6396 arg1Of and,(
R5354 T6395 T6394 arg2Of K-562,and
R5355 T6398 T6396 arg2Of 1B,(
R5356 T6398 T6397 arg1Of 1B,Figure
R5357 T6399 T6396 arg3Of ),(
R5358 T6401 T6400 arg2Of position,At
R5359 T6401 T6402 arg1Of position,−116
R5360 T6405 T6403 arg1Of substitution,an
R5361 T6405 T6404 arg1Of substitution,A→C
R5362 T6405 T6406 arg1Of substitution,was
R5363 T6405 T6407 arg2Of substitution,found
R5364 T6407 T6400 arg1Of found,At
R5365 T6407 T6406 arg2Of found,was
R5366 T6407 T6408 arg1Of found,in
R5367 T6407 T6415 arg1Of found,whereas
R5368 T6409 T6410 arg1Of EM-2,","
R5369 T6410 T6412 arg1Of ",",and
R5370 T6411 T6410 arg2Of K-562,","
R5371 T6412 T6408 arg2Of and,in
R5372 T6413 T6412 arg2Of CML-T1,and
R5373 T6415 T6414 arg1Of whereas,","
R5374 T6416 T6417 arg1Of Jurkat,","
R5375 T6417 T6419 arg1Of ",",and
R5376 T6418 T6417 arg2Of BV-173,","
R5377 T6419 T6421 arg1Of and,exhibited
R5378 T6420 T6419 arg2Of SD-1,and
R5379 T6421 T6415 arg2Of exhibited,whereas
R5380 T6422 T6431 arg1Of a,RPMI-8226
R5381 T6425 T6423 arg2Of sequence,mixed
R5382 T6425 T6424 arg1Of sequence,A/C
R5383 T6425 T6426 arg1Of sequence,and
R5384 T6426 T6421 arg2Of and,exhibited
R5385 T6426 T6422 arg1Of and,a
R5386 T6426 T6434 arg1Of and,at
R5387 T6426 T6436 arg1Of and,(
R5388 T6427 T6428 arg1Of U-937,","
R5389 T6428 T6430 arg1Of ",",and
R5390 T6429 T6428 arg2Of LAMA-84,","
R5391 T6430 T6426 arg2Of and,and
R5392 T6431 T6430 arg2Of RPMI-8226,and
R5393 T6433 T6431 arg2Of substitution,RPMI-8226
R5394 T6433 T6432 arg1Of substitution,no
R5395 T6434 T6435 arg1Of at,all
R5396 T6438 T6436 arg2Of 1B,(
R5397 T6438 T6437 arg1Of 1B,Figure
R5398 T6439 T6436 arg3Of ),(
R5399 T6443 T6442 arg1Of alterations,these
R5400 T6443 T6444 arg1Of alterations,are
R5401 T6443 T6445 arg1Of alterations,unlikely
R5402 T6443 T6447 arg1Of alterations,affect
R5403 T6444 T6440 arg1Of are,Consequently
R5404 T6444 T6441 arg1Of are,","
R5405 T6445 T6444 arg2Of unlikely,are
R5406 T6447 T6445 arg2Of affect,unlikely
R5407 T6447 T6446 arg1Of affect,to
R5408 T6449 T6447 arg2Of expression,affect
R5409 T6449 T6448 arg1Of expression,IRF-4
R5814 T7025 T7026 arg1Of Increase,of
R5815 T7025 T7029 arg1Of Increase,in
R5816 T7025 T7032 arg1Of Increase,after
R5817 T7028 T7026 arg2Of expression,of
R5818 T7028 T7027 arg1Of expression,IRF-4
R5819 T7031 T7029 arg2Of cells,in
R5820 T7031 T7030 arg1Of cells,hematopoietic
R5821 T7033 T7032 arg2Of demethylating,after
R5822 T7034 T7033 arg2Of treatment,demethylating
R5823 T7035 T7037 arg1Of We,analyzed
R5824 T7037 T7036 arg1Of analyzed,next
R5825 T7040 T7039 arg1Of methylation,promoter
R5826 T7040 T7041 arg1Of methylation,could
R5827 T7040 T7042 arg1Of methylation,be
R5828 T7040 T7043 arg1Of methylation,responsible
R5829 T7042 T7037 arg2Of be,analyzed
R5830 T7042 T7038 arg1Of be,whether
R5831 T7042 T7041 arg2Of be,could
R5832 T7043 T7042 arg2Of responsible,be
R5833 T7043 T7044 arg1Of responsible,for
R5834 T7045 T7044 arg2Of down-regulation,for
R5835 T7045 T7046 arg1Of down-regulation,of
R5836 T7048 T7046 arg2Of expression,of
R5837 T7048 T7047 arg1Of expression,IRF-4
R5838 T7050 T7049 arg1Of region,A
R5839 T7050 T7051 arg1Of region,including
R5840 T7050 T7057 arg1Of region,exhibited
R5841 T7052 T7051 arg2Of exon1,including
R5842 T7052 T7053 arg1Of exon1,in
R5843 T7056 T7053 arg2Of promoter,in
R5844 T7056 T7054 arg1Of promoter,the
R5845 T7056 T7055 arg1Of promoter,IRF-4
R5846 T7060 T7057 arg2Of number,exhibited
R5847 T7060 T7058 arg1Of number,a
R5848 T7060 T7059 arg1Of number,large
R5849 T7060 T7061 arg1Of number,of
R5850 T7063 T7061 arg2Of sequences,of
R5851 T7063 T7062 arg1Of sequences,CpG-rich
R5852 T7063 T7064 arg1Of sequences,(
R5853 T7066 T7064 arg2Of 3A,(
R5854 T7066 T7065 arg1Of 3A,Figure
R5855 T7067 T7064 arg3Of ),(
R5856 T7070 T7068 arg1Of substances,Several
R5857 T7070 T7069 arg1Of substances,chemical
R5858 T7070 T7072 arg1Of substances,as
R5859 T7070 T7082 arg1Of substances,inhibit
R5860 T7070 T7091 arg1Of substances,can
R5861 T7070 T7092 arg1Of substances,be
R5862 T7070 T7093 arg2Of substances,used
R5863 T7072 T7071 arg1Of as,such
R5864 T7073 T7074 arg1Of 5-aza-2-deoxycytidine,(
R5865 T7073 T7077 arg1Of 5-aza-2-deoxycytidine,or
R5866 T7075 T7074 arg2Of AzadC,(
R5867 T7076 T7074 arg3Of ),(
R5868 T7077 T7072 arg2Of or,as
R5869 T7078 T7077 arg2Of 5-azacytidine,or
R5870 T7078 T7079 arg1Of 5-azacytidine,(
R5871 T7080 T7079 arg2Of AzaC,(
R5872 T7081 T7079 arg3Of ),(
R5873 T7082 T7089 arg1Of inhibit,and
R5874 T7084 T7083 arg1Of novo,de
R5875 T7087 T7082 arg2Of methylation,inhibit
R5876 T7087 T7084 arg1Of methylation,novo
R5877 T7087 T7085 arg1Of methylation,and
R5878 T7087 T7086 arg1Of methylation,maintenance
R5879 T7089 T7088 arg1Of and,","
R5880 T7093 T7089 arg2Of used,and
R5881 T7093 T7090 arg1Of used,thus
R5882 T7093 T7091 arg2Of used,can
R5883 T7093 T7092 arg2Of used,be
R5884 T7095 T7093 arg3Of discern,used
R5885 T7095 T7094 arg1Of discern,to
R5886 T7097 T7095 arg2Of methylation,discern
R5887 T7097 T7096 arg1Of methylation,promoter
R5888 T7097 T7098 arg1Of methylation,(
R5889 T7099 T7098 arg2Of "32,33",(
R5890 T7100 T7098 arg3Of ),(
R5891 T7101 T7102 arg1Of We,used
R5892 T7101 T7105 arg1Of We,generate
R5893 T7103 T7102 arg2Of AzadC,used
R5894 T7105 T7102 arg3Of generate,used
R5895 T7105 T7104 arg1Of generate,to
R5896 T7107 T7105 arg2Of DNA,generate
R5897 T7107 T7106 arg1Of DNA,unmethylated
R5898 T7111 T7108 arg1Of AzadC-treatment,A
R5899 T7111 T7109 arg1Of AzadC-treatment,72
R5900 T7111 T7110 arg1Of AzadC-treatment,h
R5901 T7111 T7112 arg1Of AzadC-treatment,resulted
R5902 T7112 T7113 arg1Of resulted,in
R5903 T7112 T7128 arg1Of resulted,in
R5904 T7113 T7127 arg1Of in,as
R5905 T7116 T7113 arg2Of activation,in
R5906 T7116 T7114 arg1Of activation,a
R5907 T7116 T7115 arg1Of activation,concentration-dependent
R5908 T7116 T7117 arg1Of activation,of
R5909 T7116 T7120 arg1Of activation,in
R5910 T7119 T7117 arg2Of transcription,of
R5911 T7119 T7118 arg1Of transcription,IRF-4
R5912 T7121 T7122 arg1Of Jurkat,and
R5913 T7123 T7122 arg2Of CML-T1,and
R5914 T7124 T7120 arg2Of T-cells,in
R5915 T7124 T7121 arg1Of T-cells,Jurkat
R5916 T7124 T7123 arg1Of T-cells,CML-T1
R5917 T7127 T7125 arg1Of as,as
R5918 T7127 T7126 arg1Of as,well
R5919 T7128 T7127 arg2Of in,as
R5920 T7129 T7130 arg1Of U-937,","
R5921 T7130 T7132 arg1Of ",",and
R5922 T7131 T7130 arg2Of K-562,","
R5923 T7132 T7128 arg2Of and,in
R5924 T7135 T7132 arg2Of lines,and
R5925 T7135 T7133 arg1Of lines,EM-2
R5926 T7135 T7134 arg1Of lines,cell
R5927 T7135 T7136 arg1Of lines,(
R5928 T7138 T7136 arg2Of 2A,(
R5929 T7138 T7137 arg1Of 2A,Figure
R5930 T7139 T7136 arg3Of ),(
R5931 T7141 T7140 arg1Of transcription,IRF-4
R5932 T7141 T7142 arg1Of transcription,was
R5933 T7141 T7143 arg2Of transcription,induced
R5934 T7141 T7149 arg1Of transcription,was
R5935 T7141 T7150 arg2Of transcription,observed
R5936 T7141 T7161 arg1Of transcription,increased
R5937 T7143 T7142 arg2Of induced,was
R5938 T7143 T7144 arg1Of induced,in
R5939 T7143 T7148 arg1Of induced,and
R5940 T7147 T7144 arg2Of manner,in
R5941 T7147 T7145 arg1Of manner,a
R5942 T7147 T7146 arg1Of manner,time-dependent
R5943 T7150 T7149 arg2Of observed,was
R5944 T7150 T7152 arg1Of observed,early
R5945 T7150 T7156 arg1Of observed,after
R5946 T7150 T7160 arg1Of observed,and
R5947 T7152 T7151 arg1Of early,as
R5948 T7152 T7153 arg1Of early,as
R5949 T7155 T7153 arg2Of h,as
R5950 T7155 T7154 arg1Of h,24
R5951 T7157 T7156 arg2Of treatment,after
R5952 T7157 T7158 arg1Of treatment,with
R5953 T7159 T7158 arg2Of AzadC,with
R5954 T7160 T7148 arg2Of and,and
R5955 T7161 T7160 arg2Of increased,and
R5956 T7161 T7162 arg1Of increased,over
R5957 T7161 T7164 arg1Of increased,until
R5958 T7163 T7162 arg2Of time,over
R5959 T7166 T7164 arg2Of h,until
R5960 T7166 T7165 arg1Of h,72
R5961 T7166 T7167 arg1Of h,(
R5962 T7169 T7167 arg2Of 2B,(
R5963 T7169 T7168 arg1Of 2B,Figure
R5964 T7170 T7167 arg3Of ),(
R5965 T7171 T7172 arg1Of Time,and
R5966 T7172 T7174 arg1Of and,of
R5967 T7172 T7180 arg1Of and,varied
R5968 T7173 T7172 arg2Of strength,and
R5969 T7176 T7174 arg2Of appearance,of
R5970 T7176 T7175 arg1Of appearance,the
R5971 T7176 T7177 arg1Of appearance,of
R5972 T7179 T7177 arg2Of transcripts,of
R5973 T7179 T7178 arg1Of transcripts,IRF-4
R5974 T7180 T7181 arg1Of varied,among
R5975 T7180 T7184 arg1Of varied,","
R5976 T7183 T7181 arg2Of lines,among
R5977 T7183 T7182 arg1Of lines,cell
R5978 T7186 T7185 arg1Of CML-T1,i.e.
R5979 T7186 T7187 arg1Of CML-T1,responded
R5980 T7187 T7184 arg2Of responded,","
R5981 T7187 T7189 arg1Of responded,to
R5982 T7188 T7187 arg2Of strongest,responded
R5983 T7190 T7189 arg2Of AzadC-treatment,to
R5984 T7190 T7191 arg1Of AzadC-treatment,(
R5985 T7192 T7191 arg2Of data,(
R5986 T7192 T7194 arg2Of data,shown
R5987 T7194 T7193 arg1Of shown,not
R5988 T7195 T7191 arg3Of ),(
R5989 T7197 T7196 arg2Of line,In
R5990 T7197 T7198 arg1Of line,with
R5991 T7199 T7198 arg2Of this,with
R5992 T7201 T7202 arg1Of AzadC-treatment,of
R5993 T7201 T7208 arg1Of AzadC-treatment,translated
R5994 T7203 T7204 arg1Of CML-T1,and
R5995 T7205 T7204 arg2Of LAMA-84,and
R5996 T7206 T7202 arg2Of cells,of
R5997 T7206 T7203 arg1Of cells,CML-T1
R5998 T7206 T7205 arg1Of cells,LAMA-84
R5999 T7208 T7196 arg1Of translated,In
R6000 T7208 T7200 arg1Of translated,","
R6001 T7208 T7207 arg1Of translated,also
R6002 T7208 T7209 arg1Of translated,in
R6003 T7211 T7209 arg2Of induction,in
R6004 T7211 T7210 arg1Of induction,an
R6005 T7211 T7212 arg1Of induction,of
R6006 T7215 T7212 arg2Of expression,of
R6007 T7215 T7213 arg1Of expression,IRF-4
R6008 T7215 T7214 arg1Of expression,protein
R6009 T7215 T7216 arg1Of expression,(
R6010 T7218 T7216 arg2Of 2C,(
R6011 T7218 T7217 arg1Of 2C,Figure
R6012 T7219 T7216 arg3Of ),(
R6013 T7222 T7223 arg1Of treatment,of
R6014 T7222 T7229 arg1Of treatment,","
R6015 T7228 T7223 arg2Of BV-173,of
R6016 T7228 T7224 arg1Of BV-173,the
R6017 T7228 T7225 arg1Of BV-173,IRF-4-positive
R6018 T7228 T7226 arg1Of BV-173,cell
R6019 T7228 T7227 arg1Of BV-173,line
R6020 T7229 T7235 arg1Of ",",had
R6021 T7230 T7231 arg1Of SD-1,and
R6022 T7231 T7229 arg2Of and,","
R6023 T7231 T7233 arg1Of and,with
R6024 T7232 T7231 arg2Of RPMI-8226,and
R6025 T7234 T7233 arg2Of AzadC,with
R6026 T7235 T7220 arg1Of had,Accordingly
R6027 T7235 T7221 arg1Of had,","
R6028 T7237 T7235 arg2Of effect,had
R6029 T7237 T7236 arg1Of effect,no
R6030 T7237 T7238 arg1Of effect,on
R6031 T7240 T7238 arg2Of expression,on
R6032 T7240 T7239 arg1Of expression,IRF-4
R6033 T7240 T7241 arg1Of expression,(
R6034 T7243 T7241 arg2Of 2D,(
R6035 T7243 T7242 arg1Of 2D,Figure
R6036 T7244 T7241 arg3Of ),(
R6037 T7245 T7246 arg1Of There,was
R6038 T7246 T7249 arg1Of was,in
R6039 T7246 T7256 arg1Of was,","
R6040 T7246 T7257 arg1Of was,as
R6041 T7248 T7246 arg2Of difference,was
R6042 T7248 T7247 arg1Of difference,no
R6043 T7251 T7249 arg2Of effects,in
R6044 T7251 T7250 arg1Of effects,the
R6045 T7251 T7252 arg1Of effects,of
R6046 T7253 T7252 arg2Of AzaC,of
R6047 T7253 T7254 arg1Of AzaC,versus
R6048 T7255 T7254 arg2Of AzadC,versus
R6049 T7258 T7259 arg1Of both,increased
R6050 T7259 T7257 arg2Of increased,as
R6051 T7259 T7267 arg1Of increased,as
R6052 T7263 T7259 arg2Of level,increased
R6053 T7263 T7260 arg1Of level,the
R6054 T7263 T7261 arg1Of level,IRF-4
R6055 T7263 T7262 arg1Of level,mRNA
R6056 T7263 T7264 arg1Of level,in
R6057 T7266 T7264 arg2Of cells,in
R6058 T7266 T7265 arg1Of cells,CML-T1
R6059 T7268 T7267 arg2Of well,as
R6060 T7268 T7269 arg1Of well,(
R6061 T7270 T7269 arg2Of data,(
R6062 T7270 T7272 arg2Of data,shown
R6063 T7272 T7271 arg1Of shown,not
R6064 T7273 T7269 arg3Of ),(
R6065 T7274 T7275 arg1Of This,implied
R6066 T7278 T7277 arg1Of methylation,promoter
R6067 T7278 T7279 arg1Of methylation,may
R6068 T7278 T7280 arg1Of methylation,control
R6069 T7280 T7279 arg2Of control,may
R6070 T7280 T7284 arg1Of control,but
R6071 T7282 T7280 arg2Of expression,control
R6072 T7282 T7281 arg1Of expression,IRF-4
R6073 T7284 T7275 arg2Of but,implied
R6074 T7284 T7276 arg1Of but,that
R6075 T7284 T7283 arg1Of but,","
R6076 T7287 T7285 arg1Of explanation,an
R6077 T7287 T7286 arg1Of explanation,alternative
R6078 T7287 T7288 arg1Of explanation,may
R6079 T7287 T7289 arg1Of explanation,be
R6080 T7289 T7284 arg2Of be,but
R6081 T7289 T7288 arg2Of be,may
R6082 T7289 T7297 arg1Of be,by
R6083 T7290 T7289 arg2Of activation,be
R6084 T7290 T7291 arg1Of activation,of
R6085 T7294 T7291 arg2Of regulators,of
R6086 T7294 T7292 arg1Of regulators,positive
R6087 T7294 T7293 arg1Of regulators,transcriptional
R6088 T7294 T7295 arg1Of regulators,of
R6089 T7296 T7295 arg2Of IRF-4,of
R6090 T7298 T7297 arg2Of AzadC,by
R6091 T7298 T7299 arg1Of AzadC,(
R6092 T7301 T7299 arg2Of AzaC,(
R6093 T7301 T7300 arg1Of AzaC,or
R6094 T7302 T7299 arg3Of ),(
R6497 T7853 T7852 arg1Of enzymes,Methylation-sensitive
R6498 T7853 T7854 arg1Of enzymes,do
R6499 T7853 T7856 arg1Of enzymes,cut
R6500 T7856 T7854 arg2Of cut,do
R6501 T7856 T7855 arg1Of cut,not
R6502 T7858 T7856 arg2Of sites,cut
R6503 T7858 T7857 arg1Of sites,specific
R6504 T7858 T7859 arg1Of sites,in
R6505 T7862 T7859 arg2Of promoter,in
R6506 T7862 T7860 arg1Of promoter,the
R6507 T7862 T7861 arg1Of promoter,IRF-4
R6508 T7862 T7863 arg1Of promoter,in
R6509 T7865 T7863 arg2Of cells,in
R6510 T7865 T7864 arg1Of cells,hematopoietic
R6511 T7868 T7866 arg1Of investigate,To
R6512 T7868 T7867 arg1Of investigate,further
R6513 T7868 T7871 arg1Of investigate,as
R6514 T7870 T7868 arg2Of methylation,investigate
R6515 T7870 T7869 arg1Of methylation,promoter
R6516 T7874 T7871 arg2Of mechanism,as
R6517 T7874 T7872 arg1Of mechanism,a
R6518 T7874 T7873 arg1Of mechanism,regulatory
R6519 T7874 T7875 arg1Of mechanism,of
R6520 T7878 T7875 arg2Of expression,of
R6521 T7878 T7876 arg1Of expression,IRF-4
R6522 T7878 T7877 arg1Of expression,gene
R6523 T7880 T7868 arg1Of restriction-PCR-assays,investigate
R6524 T7880 T7881 arg1Of restriction-PCR-assays,were
R6525 T7880 T7882 arg2Of restriction-PCR-assays,performed
R6526 T7882 T7866 modOf performed,To
R6527 T7882 T7879 arg1Of performed,","
R6528 T7882 T7881 arg2Of performed,were
R6529 T7882 T7883 arg1Of performed,(
R6530 T7882 T7886 arg1Of performed,","
R6531 T7882 T7887 arg1Of performed,where
R6532 T7884 T7883 arg2Of "20,24",(
R6533 T7885 T7883 arg3Of ),(
R6534 T7890 T7888 arg1Of DNA,only
R6535 T7890 T7889 arg2Of DNA,methylated
R6536 T7890 T7891 arg1Of DNA,would
R6537 T7890 T7893 arg1Of DNA,be
R6538 T7890 T7894 arg2Of DNA,cut
R6539 T7890 T7895 arg1Of DNA,enabling
R6540 T7894 T7887 arg2Of cut,where
R6541 T7894 T7891 arg2Of cut,would
R6542 T7894 T7892 arg1Of cut,not
R6543 T7894 T7893 arg2Of cut,be
R6544 T7894 T7895 modOf cut,enabling
R6545 T7898 T7896 arg1Of amplification,subsequent
R6546 T7898 T7897 arg1Of amplification,PCR
R6547 T7898 T7899 arg1Of amplification,and
R6548 T7899 T7895 arg2Of and,enabling
R6549 T7901 T7899 arg2Of versa,and
R6550 T7901 T7900 arg1Of versa,vice
R6551 T7903 T7902 arg1Of DNA,Genomic
R6552 T7903 T7904 arg1Of DNA,from
R6553 T7903 T7918 arg1Of DNA,was
R6554 T7903 T7919 arg2Of DNA,digested
R6555 T7906 T7905 arg1Of cells,leukemic
R6556 T7907 T7908 arg1Of Jurkat,","
R6557 T7908 T7910 arg1Of ",",","
R6558 T7909 T7908 arg2Of CML-T1,","
R6559 T7910 T7912 arg1Of ",",","
R6560 T7911 T7910 arg2Of U-937,","
R6561 T7912 T7914 arg1Of ",",","
R6562 T7913 T7912 arg2Of K-562,","
R6563 T7914 T7906 arg1Of ",",cells
R6564 T7914 T7916 arg1Of ",",and
R6565 T7915 T7914 arg2Of EM-2,","
R6566 T7916 T7904 arg2Of and,from
R6567 T7917 T7916 arg2Of BV-173,and
R6568 T7919 T7918 arg2Of digested,was
R6569 T7919 T7920 arg1Of digested,with
R6570 T7923 T7921 arg1Of enzymes,the
R6571 T7923 T7922 arg1Of enzymes,methylation-sensitive
R6572 T7924 T7925 arg1Of HpaII,","
R6573 T7925 T7927 arg1Of ",",and
R6574 T7926 T7925 arg2Of Bsh1236I,","
R6575 T7927 T7920 arg2Of and,with
R6576 T7927 T7923 arg1Of and,enzymes
R6577 T7929 T7927 arg2Of Bsp143II,and
R6578 T7929 T7928 arg1Of Bsp143II,HaeII-isochizomer
R6579 T7930 T7931 arg1Of EcoRI,","
R6580 T7930 T7932 arg1Of EcoRI,which
R6581 T7930 T7933 arg1Of EcoRI,has
R6582 T7936 T7934 arg1Of site,no
R6583 T7936 T7935 arg1Of site,recognition
R6584 T7936 T7937 arg1Of site,within
R6585 T7936 T7942 arg1Of site,and
R6586 T7940 T7937 arg2Of promoter,within
R6587 T7940 T7938 arg1Of promoter,the
R6588 T7940 T7939 arg1Of promoter,IRF-4
R6589 T7942 T7933 arg2Of and,has
R6590 T7942 T7941 arg1Of and,","
R6591 T7946 T7942 arg2Of MspI,and
R6592 T7946 T7943 arg1Of MspI,the
R6593 T7946 T7944 arg1Of MspI,methylation-resistant
R6594 T7946 T7945 arg1Of MspI,enzyme
R6595 T7946 T7947 arg2Of MspI,served
R6596 T7947 T7948 arg1Of served,as
R6597 T7949 T7948 arg2Of controls,as
R6598 T7953 T7950 arg1Of reactions,Two
R6599 T7953 T7951 arg1Of reactions,separate
R6600 T7953 T7952 arg1Of reactions,amplification
R6601 T7953 T7954 arg1Of reactions,were
R6602 T7953 T7955 arg2Of reactions,performed
R6603 T7955 T7954 arg2Of performed,were
R6604 T7955 T7956 arg1Of performed,","
R6605 T7955 T7957 modOf performed,generating
R6606 T7959 T7957 arg2Of fragments,generating
R6607 T7959 T7958 arg1Of fragments,two
R6608 T7959 T7960 arg1Of fragments,","
R6609 T7961 T7962 arg1Of F1,and
R6610 T7962 T7960 arg2Of and,","
R6611 T7962 T7964 arg1Of and,(
R6612 T7963 T7962 arg2Of F2,and
R6613 T7966 T7964 arg2Of 3A,(
R6614 T7966 T7965 arg1Of 3A,Figure
R6615 T7967 T7964 arg3Of ),(
R6616 T7969 T7968 arg2Of digestion,After
R6617 T7969 T7970 arg1Of digestion,with
R6618 T7971 T7972 arg1Of HpaII,and
R6619 T7972 T7970 arg2Of and,with
R6620 T7973 T7972 arg2Of Bsp143II,and
R6621 T7977 T7974 arg1Of amplification,a
R6622 T7977 T7975 arg1Of amplification,sufficient
R6623 T7977 T7976 arg1Of amplification,PCR
R6624 T7977 T7978 arg1Of amplification,of
R6625 T7977 T7982 arg1Of amplification,was
R6626 T7977 T7983 arg2Of amplification,detected
R6627 T7979 T7980 arg1Of F1,and
R6628 T7980 T7978 arg2Of and,of
R6629 T7981 T7980 arg2Of F2,and
R6630 T7983 T7968 arg1Of detected,After
R6631 T7983 T7982 arg2Of detected,was
R6632 T7983 T7984 arg1Of detected,in
R6633 T7983 T7986 arg1Of detected,from
R6634 T7983 T7998 arg1Of detected,","
R6635 T7983 T7999 modOf detected,suggesting
R6636 T7985 T7984 arg2Of DNA,in
R6637 T7988 T7987 arg1Of Jurkat,IRF-4-negative
R6638 T7988 T7989 arg1Of Jurkat,","
R6639 T7989 T7991 arg1Of ",",","
R6640 T7990 T7989 arg2Of CML-T1,","
R6641 T7991 T7993 arg1Of ",",","
R6642 T7992 T7991 arg2Of U-937,","
R6643 T7993 T7995 arg1Of ",",and
R6644 T7994 T7993 arg2Of K-562,","
R6645 T7995 T7986 arg2Of and,from
R6646 T7997 T7995 arg2Of cells,and
R6647 T7997 T7996 arg1Of cells,EM-2
R6648 T8002 T7999 arg2Of methylation,suggesting
R6649 T8002 T8000 arg1Of methylation,a
R6650 T8002 T8001 arg1Of methylation,promoter
R6651 T8002 T8003 arg1Of methylation,(
R6652 T8002 T8008 arg1Of methylation,at
R6653 T8006 T8003 arg2Of protection,(
R6654 T8006 T8004 arg1Of protection,and
R6655 T8006 T8005 arg1Of protection,restriction
R6656 T8007 T8003 arg3Of ),(
R6657 T8012 T8008 arg2Of sites,at
R6658 T8012 T8009 arg1Of sites,the
R6659 T8012 T8010 arg1Of sites,respective
R6660 T8012 T8011 arg1Of sites,recognition
R6661 T8012 T8013 arg1Of sites,(
R6662 T8015 T8014 arg1Of 3B,Figure
R6663 T8015 T8016 arg1Of 3B,and
R6664 T8016 T8013 arg2Of and,(
R6665 T8017 T8016 arg2Of C,and
R6666 T8018 T8013 arg3Of ),(
R6667 T8024 T8021 arg2Of cells,in
R6668 T8024 T8022 arg1Of cells,IRF-4-positive
R6669 T8024 T8023 arg1Of cells,SD-1
R6670 T8025 T8026 arg1Of digestion,with
R6671 T8025 T8031 arg1Of digestion,inhibited
R6672 T8029 T8026 arg2Of enzymes,with
R6673 T8029 T8027 arg1Of enzymes,the
R6674 T8029 T8028 arg1Of enzymes,methylation-sensitive
R6675 T8031 T8019 arg1Of inhibited,Notably
R6676 T8031 T8020 arg1Of inhibited,","
R6677 T8031 T8021 arg1Of inhibited,in
R6678 T8031 T8030 arg1Of inhibited,completely
R6679 T8032 T8031 arg2Of amplification,inhibited
R6680 T8032 T8033 arg1Of amplification,of
R6681 T8034 T8035 arg1Of F1,and
R6682 T8035 T8033 arg2Of and,of
R6683 T8036 T8035 arg2Of F2,and
R6684 T8040 T8037 arg2Of cells,In
R6685 T8040 T8038 arg1Of cells,IRF-4-positive
R6686 T8040 T8039 arg1Of cells,BV-173
R6687 T8042 T8041 arg1Of HpaII,a
R6688 T8042 T8044 arg1Of HpaII,but
R6689 T8044 T8043 arg1Of but,","
R6690 T8044 T8045 arg1Of but,not
R6691 T8044 T8051 arg1Of but,reduced
R6692 T8048 T8044 arg2Of digestion,but
R6693 T8048 T8046 arg1Of digestion,a
R6694 T8048 T8047 arg1Of digestion,Bsh1236I
R6695 T8051 T8049 arg1Of reduced,","
R6696 T8051 T8050 arg1Of reduced,significantly
R6697 T8051 T8063 arg1Of reduced,whereas
R6698 T8055 T8051 arg2Of message,reduced
R6699 T8055 T8052 arg1Of message,the
R6700 T8055 T8053 arg1Of message,amplifiable
R6701 T8055 T8054 arg1Of message,DNA
R6702 T8055 T8056 arg1Of message,of
R6703 T8057 T8056 arg2Of F2,of
R6704 T8057 T8058 arg1Of F2,(
R6705 T8060 T8058 arg2Of 3C,(
R6706 T8060 T8059 arg1Of 3C,Figure
R6707 T8061 T8058 arg3Of ),(
R6708 T8063 T8037 arg1Of whereas,In
R6709 T8063 T8062 arg1Of whereas,","
R6710 T8064 T8065 arg1Of amplification,of
R6711 T8064 T8067 arg1Of amplification,was
R6712 T8064 T8069 arg2Of amplification,affected
R6713 T8066 T8065 arg2Of F1,of
R6714 T8069 T8063 arg2Of affected,whereas
R6715 T8069 T8067 arg2Of affected,was
R6716 T8069 T8068 arg1Of affected,not
R6717 T8069 T8070 arg1Of affected,(
R6718 T8072 T8070 arg2Of 3B,(
R6719 T8072 T8071 arg1Of 3B,Figure
R6720 T8073 T8070 arg3Of ),(
R6721 T8074 T8075 arg1Of This,implied
R6722 T8078 T8077 arg1Of transcription,IRF-4
R6723 T8078 T8079 arg1Of transcription,in
R6724 T8078 T8084 arg1Of transcription,is
R6725 T8078 T8085 arg2Of transcription,associated
R6726 T8080 T8081 arg1Of SD-1,and
R6727 T8082 T8081 arg2Of BV-173,and
R6728 T8083 T8079 arg2Of cells,in
R6729 T8083 T8080 arg1Of cells,SD-1
R6730 T8083 T8082 arg1Of cells,BV-173
R6731 T8085 T8075 arg2Of associated,implied
R6732 T8085 T8076 arg1Of associated,that
R6733 T8085 T8084 arg2Of associated,is
R6734 T8085 T8086 arg1Of associated,with
R6735 T8085 T8090 arg1Of associated,(
R6736 T8085 T8098 arg1Of associated,as
R6737 T8089 T8086 arg2Of methylation,with
R6738 T8089 T8087 arg1Of methylation,less
R6739 T8089 T8088 arg1Of methylation,promoter
R6740 T8091 T8090 arg2Of in,(
R6741 T8092 T8091 arg2Of BV-173,in
R6742 T8092 T8094 arg1Of BV-173,at
R6743 T8094 T8093 arg1Of at,especially
R6744 T8096 T8094 arg2Of sites,at
R6745 T8096 T8095 arg1Of sites,HpaII
R6746 T8097 T8090 arg3Of ),(
R6747 T8099 T8098 arg2Of compared,as
R6748 T8099 T8100 arg1Of compared,with
R6749 T8104 T8100 arg2Of cells,with
R6750 T8104 T8101 arg1Of cells,the
R6751 T8104 T8102 arg2Of cells,tested
R6752 T8104 T8103 arg1Of cells,IRF-4-negative
R7082 T8580 T8578 arg1Of sites,Specific
R7083 T8580 T8579 arg1Of sites,CpG
R7084 T8580 T8581 arg1Of sites,in
R7085 T8580 T8585 arg1Of sites,are
R7086 T8580 T8586 arg2Of sites,methylated
R7087 T8584 T8581 arg2Of promoter,in
R7088 T8584 T8582 arg1Of promoter,the
R7089 T8584 T8583 arg1Of promoter,IRF-4
R7090 T8586 T8585 arg2Of methylated,are
R7091 T8586 T8587 arg1Of methylated,in
R7092 T8589 T8587 arg2Of cells,in
R7093 T8589 T8588 arg1Of cells,hematopoietic
R7094 T8591 T8590 arg2Of order,In
R7095 T8594 T8590 arg3Of map,In
R7096 T8594 T8592 arg1Of map,to
R7097 T8594 T8593 arg1Of map,exactly
R7098 T8597 T8594 arg2Of sites,map
R7099 T8597 T8595 arg1Of sites,the
R7100 T8597 T8596 arg1Of sites,methylation
R7101 T8597 T8598 arg1Of sites,within
R7102 T8601 T8598 arg2Of promoter,within
R7103 T8601 T8599 arg1Of promoter,the
R7104 T8601 T8600 arg1Of promoter,IRF-4
R7105 T8603 T8594 arg1Of we,map
R7106 T8603 T8604 arg1Of we,treated
R7107 T8604 T8590 arg1Of treated,In
R7108 T8604 T8602 arg1Of treated,","
R7109 T8604 T8638 arg1Of treated,","
R7110 T8604 T8639 arg1Of treated,whereas
R7111 T8605 T8604 arg2Of DNA,treated
R7112 T8605 T8606 arg1Of DNA,of
R7113 T8605 T8620 arg1Of DNA,of
R7114 T8606 T8619 arg1Of of,as
R7115 T8607 T8608 arg1Of Jurkat,","
R7116 T8608 T8610 arg1Of ",",","
R7117 T8609 T8608 arg2Of CML-T1,","
R7118 T8610 T8612 arg1Of ",",","
R7119 T8611 T8610 arg2Of U-937,","
R7120 T8612 T8614 arg1Of ",",and
R7121 T8613 T8612 arg2Of K-562,","
R7122 T8615 T8614 arg2Of EM-2,and
R7123 T8616 T8606 arg2Of cells,of
R7124 T8616 T8607 arg1Of cells,Jurkat
R7125 T8616 T8609 arg1Of cells,CML-T1
R7126 T8616 T8611 arg1Of cells,U-937
R7127 T8616 T8613 arg1Of cells,K-562
R7128 T8616 T8615 arg1Of cells,EM-2
R7129 T8619 T8617 arg1Of as,as
R7130 T8619 T8618 arg1Of as,well
R7131 T8620 T8619 arg2Of of,as
R7132 T8621 T8622 arg1Of SD-1,","
R7133 T8622 T8624 arg1Of ",",and
R7134 T8623 T8622 arg2Of RPMI-8226,","
R7135 T8624 T8620 arg2Of and,of
R7136 T8624 T8628 arg1Of and,with
R7137 T8624 T8630 arg1Of and,","
R7138 T8624 T8631 arg1Of and,which
R7139 T8624 T8633 arg1Of and,converts
R7140 T8627 T8624 arg2Of cells,and
R7141 T8627 T8625 arg1Of cells,BV-173
R7142 T8627 T8626 arg1Of cells,control
R7143 T8629 T8628 arg2Of bisulfite,with
R7144 T8633 T8632 arg1Of converts,chemically
R7145 T8633 T8636 arg1Of converts,to
R7146 T8635 T8633 arg2Of cytosine,converts
R7147 T8635 T8634 arg1Of cytosine,unmethylated
R7148 T8637 T8636 arg2Of uracil,to
R7149 T8640 T8641 arg1Of it,has
R7150 T8641 T8639 arg2Of has,whereas
R7151 T8641 T8644 arg1Of has,on
R7152 T8641 T8647 arg1Of has,","
R7153 T8641 T8648 arg1Of has,i.e.
R7154 T8641 T8649 arg1Of has,in
R7155 T8643 T8641 arg2Of effect,has
R7156 T8643 T8642 arg1Of effect,no
R7157 T8646 T8644 arg2Of cytosine,on
R7158 T8646 T8645 arg2Of cytosine,methylated
R7159 T8650 T8649 arg2Of CpG,in
R7160 T8650 T8651 arg1Of CpG,(
R7161 T8652 T8651 arg2Of 34,(
R7162 T8653 T8651 arg3Of ),(
R7163 T8655 T8654 arg1Of technique,This
R7164 T8655 T8656 arg1Of technique,is
R7165 T8655 T8658 arg1Of technique,useful
R7166 T8658 T8656 arg2Of useful,is
R7167 T8658 T8657 arg1Of useful,especially
R7168 T8658 T8659 arg1Of useful,for
R7169 T8660 T8659 arg2Of detection,for
R7170 T8660 T8661 arg1Of detection,of
R7171 T8664 T8661 arg2Of patterns,of
R7172 T8664 T8662 arg1Of patterns,unknown
R7173 T8664 T8663 arg1Of patterns,methylation
R7174 T8666 T8665 arg1Of amplification,PCR
R7175 T8666 T8667 arg1Of amplification,","
R7176 T8667 T8669 arg1Of ",",and
R7177 T8668 T8667 arg2Of cloning,","
R7178 T8669 T8671 arg1Of and,of
R7179 T8669 T8675 arg1Of and,showed
R7180 T8670 T8669 arg2Of sequencing,and
R7181 T8674 T8671 arg2Of DNA,of
R7182 T8674 T8672 arg1Of DNA,the
R7183 T8674 T8673 arg1Of DNA,bisulfite-treated
R7184 T8679 T8675 arg2Of pattern,showed
R7185 T8679 T8676 arg1Of pattern,a
R7186 T8679 T8677 arg1Of pattern,specific
R7187 T8679 T8678 arg1Of pattern,methylation
R7188 T8679 T8680 arg1Of pattern,of
R7189 T8679 T8686 arg1Of pattern,in
R7190 T8685 T8680 arg2Of sites,of
R7191 T8685 T8681 arg1Of sites,the
R7192 T8685 T8682 arg2Of sites,analyzed
R7193 T8685 T8683 arg1Of sites,62
R7194 T8685 T8684 arg1Of sites,CpG
R7195 T8689 T8686 arg2Of lines,in
R7196 T8689 T8687 arg1Of lines,all
R7197 T8689 T8688 arg1Of lines,cell
R7198 T8689 T8690 arg1Of lines,(
R7199 T8691 T8692 arg1Of Figure,4
R7200 T8691 T8693 arg1Of Figure,and
R7201 T8693 T8690 arg2Of and,(
R7202 T8694 T8693 arg2Of Table,and
R7203 T8694 T8695 arg1Of Table,1
R7204 T8696 T8690 arg3Of ),(
R7205 T8698 T8697 arg2Of general,In
R7206 T8702 T8700 arg1Of status,the
R7207 T8702 T8701 arg1Of status,methylational
R7208 T8702 T8703 arg1Of status,ranged
R7209 T8703 T8697 arg1Of ranged,In
R7210 T8703 T8699 arg1Of ranged,","
R7211 T8703 T8704 arg1Of ranged,from
R7212 T8707 T8704 arg2Of line,from
R7213 T8707 T8705 arg1Of line,one
R7214 T8707 T8706 arg1Of line,cell
R7215 T8707 T8708 arg1Of line,with
R7216 T8711 T8710 arg1Of non-methylated,nearly
R7217 T8713 T8708 arg2Of promoter,with
R7218 T8713 T8709 arg1Of promoter,a
R7219 T8713 T8711 arg1Of promoter,non-methylated
R7220 T8713 T8712 arg1Of promoter,IRF-4
R7221 T8713 T8714 arg1Of promoter,(
R7222 T8713 T8719 arg1Of promoter,to
R7223 T8715 T8714 arg2Of SD-1,(
R7224 T8715 T8716 arg1Of SD-1,","
R7225 T8717 T8716 arg2Of IRF-4-positive,","
R7226 T8718 T8714 arg3Of ),(
R7227 T8722 T8721 arg1Of methylated,completely
R7228 T8724 T8719 arg2Of promoter,to
R7229 T8724 T8720 arg1Of promoter,a
R7230 T8724 T8722 arg1Of promoter,methylated
R7231 T8724 T8723 arg1Of promoter,IRF-4
R7232 T8724 T8725 arg1Of promoter,in
R7233 T8726 T8725 arg2Of CML-T1,in
R7234 T8726 T8727 arg1Of CML-T1,(
R7235 T8728 T8727 arg2Of IRF-4-negative,(
R7236 T8729 T8727 arg3Of ),(
R7237 T8733 T8732 arg1Of percentage,the
R7238 T8733 T8734 arg1Of percentage,of
R7239 T8733 T8737 arg1Of percentage,in
R7240 T8733 T8744 arg1Of percentage,was
R7241 T8733 T8746 arg1Of percentage,low
R7242 T8736 T8734 arg2Of methylation,of
R7243 T8736 T8735 arg1Of methylation,CpG
R7244 T8740 T8737 arg2Of promoter,in
R7245 T8740 T8738 arg1Of promoter,the
R7246 T8740 T8739 arg1Of promoter,IRF-4
R7247 T8740 T8741 arg1Of promoter,from
R7248 T8743 T8741 arg2Of cells,from
R7249 T8743 T8742 arg1Of cells,IRF-4-positive
R7250 T8744 T8730 arg1Of was,Interestingly
R7251 T8744 T8731 arg1Of was,","
R7252 T8746 T8744 arg2Of low,was
R7253 T8746 T8745 arg1Of low,very
R7254 T8746 T8747 arg1Of low,(
R7255 T8750 T8747 arg2Of %,(
R7256 T8750 T8748 arg1Of %,mean
R7257 T8750 T8749 arg1Of %,24
R7258 T8751 T8747 arg3Of ),(
R7259 T8752 T8744 arg3Of as,was
R7260 T8753 T8752 arg2Of compared,as
R7261 T8753 T8754 arg1Of compared,with
R7262 T8756 T8754 arg2Of cells,with
R7263 T8756 T8755 arg1Of cells,IRF-4-negative
R7264 T8756 T8757 arg1Of cells,(
R7265 T8756 T8762 arg1Of cells,(
R7266 T8760 T8757 arg2Of %,(
R7267 T8760 T8758 arg1Of %,mean
R7268 T8760 T8759 arg1Of %,94
R7269 T8761 T8757 arg3Of ),(
R7270 T8764 T8763 arg1Of 4A,Figure
R7271 T8764 T8765 arg1Of 4A,and
R7272 T8765 T8762 arg2Of and,(
R7273 T8767 T8765 arg2Of 1,and
R7274 T8767 T8766 arg1Of 1,Table
R7275 T8768 T8762 arg3Of ),(
R7276 T8770 T8769 arg1Of 5′-region,A
R7277 T8770 T8771 arg1Of 5′-region,(
R7278 T8770 T8774 arg1Of 5′-region,with
R7279 T8770 T8794 arg1Of 5′-region,was
R7280 T8770 T8795 arg2Of 5′-region,found
R7281 T8772 T8771 arg2Of R1,(
R7282 T8773 T8771 arg3Of ),(
R7283 T8778 T8774 arg2Of sites,with
R7284 T8778 T8775 arg1Of sites,13
R7285 T8778 T8776 arg2Of sites,hypermethylated
R7286 T8778 T8777 arg1Of sites,CpG
R7287 T8778 T8779 arg1Of sites,(
R7288 T8781 T8779 arg2Of number,(
R7289 T8781 T8780 arg1Of number,mean
R7290 T8781 T8782 arg1Of number,of
R7291 T8781 T8785 arg1Of number,5.5
R7292 T8784 T8782 arg2Of clones,of
R7293 T8784 T8783 arg2Of clones,methylated
R7294 T8785 T8786 arg1Of 5.5,of
R7295 T8785 T8788 arg1Of 5.5,with
R7296 T8787 T8786 arg2Of 8,of
R7297 T8789 T8790 arg1Of 77,%
R7298 T8792 T8788 arg2Of CpGs,with
R7299 T8792 T8789 arg1Of CpGs,77
R7300 T8792 T8791 arg2Of CpGs,methylated
R7301 T8793 T8779 arg3Of ),(
R7302 T8795 T8794 arg2Of found,was
R7303 T8795 T8796 arg1Of found,in
R7304 T8795 T8799 arg1Of found,(
R7305 T8795 T8805 arg1Of found,and
R7306 T8798 T8796 arg2Of cells,in
R7307 T8798 T8797 arg1Of cells,most
R7308 T8800 T8799 arg2Of except,(
R7309 T8801 T8802 arg1Of SD-1,and
R7310 T8802 T8800 arg2Of and,except
R7311 T8803 T8802 arg2Of RPMI-8226,and
R7312 T8804 T8799 arg3Of ),(
R7313 T8807 T8806 arg1Of 3′-region,a
R7314 T8807 T8808 arg1Of 3′-region,(
R7315 T8807 T8811 arg1Of 3′-region,of
R7316 T8807 T8831 arg1Of 3′-region,was
R7317 T8807 T8832 arg2Of 3′-region,found
R7318 T8809 T8808 arg2Of R3,(
R7319 T8810 T8808 arg3Of ),(
R7320 T8815 T8811 arg2Of sites,of
R7321 T8815 T8812 arg1Of sites,6
R7322 T8815 T8813 arg2Of sites,hypomethylated
R7323 T8815 T8814 arg1Of sites,CpG
R7324 T8815 T8816 arg1Of sites,(
R7325 T8818 T8816 arg2Of number,(
R7326 T8818 T8817 arg1Of number,mean
R7327 T8818 T8819 arg1Of number,of
R7328 T8818 T8822 arg1Of number,1.7
R7329 T8821 T8819 arg2Of clones,of
R7330 T8821 T8820 arg2Of clones,methylated
R7331 T8822 T8823 arg1Of 1.7,of
R7332 T8822 T8825 arg1Of 1.7,with
R7333 T8824 T8823 arg2Of 8,of
R7334 T8826 T8827 arg1Of 33,%
R7335 T8829 T8825 arg2Of CpGs,with
R7336 T8829 T8826 arg1Of CpGs,33
R7337 T8829 T8828 arg2Of CpGs,methylated
R7338 T8830 T8816 arg3Of ),(
R7339 T8832 T8805 arg2Of found,and
R7340 T8832 T8831 arg2Of found,was
R7341 T8832 T8833 arg1Of found,in
R7342 T8835 T8833 arg2Of cells,in
R7343 T8835 T8834 arg1Of cells,most
R7344 T8835 T8836 arg1Of cells,(
R7345 T8835 T8842 arg1Of cells,(
R7346 T8837 T8836 arg2Of except,(
R7347 T8838 T8839 arg1Of CML-T1,and
R7348 T8839 T8837 arg2Of and,except
R7349 T8840 T8839 arg2Of U-937,and
R7350 T8841 T8836 arg3Of ),(
R7351 T8844 T8843 arg1Of 4A,Figure
R7352 T8844 T8845 arg1Of 4A,and
R7353 T8845 T8842 arg2Of and,(
R7354 T8847 T8845 arg2Of 1,and
R7355 T8847 T8846 arg1Of 1,Table
R7356 T8848 T8842 arg3Of ),(
R7357 T8852 T8851 arg1Of stretch,a
R7358 T8852 T8853 arg1Of stretch,of
R7359 T8852 T8863 arg1Of stretch,was
R7360 T8852 T8864 arg2Of stretch,detected
R7361 T8856 T8853 arg2Of sites,of
R7362 T8856 T8854 arg1Of sites,13
R7363 T8856 T8855 arg1Of sites,CpG
R7364 T8856 T8857 arg1Of sites,(
R7365 T8859 T8857 arg2Of 10–22,(
R7366 T8859 T8858 arg1Of 10–22,#
R7367 T8859 T8860 arg1Of 10–22,;
R7368 T8861 T8860 arg2Of R2,;
R7369 T8862 T8857 arg3Of ),(
R7370 T8864 T8849 arg1Of detected,Intriguingly
R7371 T8864 T8850 arg1Of detected,","
R7372 T8864 T8863 arg2Of detected,was
R7373 T8864 T8865 arg1Of detected,in
R7374 T8864 T8866 arg1Of detected,between
R7375 T8868 T8866 arg2Of regions,between
R7376 T8868 T8867 arg1Of regions,these
R7377 T8868 T8869 arg1Of regions,","
R7378 T8868 T8870 arg1Of regions,which
R7379 T8868 T8871 arg1Of regions,were
R7380 T8868 T8873 arg2Of regions,methylated
R7381 T8868 T8893 arg1Of regions,non-methylated
R7382 T8873 T8872 arg1Of methylated,highly
R7383 T8873 T8874 arg1Of methylated,in
R7384 T8873 T8891 arg1Of methylated,but
R7385 T8875 T8874 arg2Of IRF-4-negative,in
R7386 T8875 T8876 arg1Of IRF-4-negative,(
R7387 T8878 T8876 arg2Of number,(
R7388 T8878 T8877 arg1Of number,mean
R7389 T8878 T8879 arg1Of number,of
R7390 T8878 T8882 arg1Of number,7.1
R7391 T8881 T8879 arg2Of clones,of
R7392 T8881 T8880 arg2Of clones,methylated
R7393 T8882 T8883 arg1Of 7.1,of
R7394 T8882 T8885 arg1Of 7.1,with
R7395 T8884 T8883 arg2Of 8,of
R7396 T8886 T8887 arg1Of 89,%
R7397 T8889 T8885 arg2Of CpGs,with
R7398 T8889 T8886 arg1Of CpGs,89
R7399 T8889 T8888 arg2Of CpGs,methylated
R7400 T8890 T8876 arg3Of ),(
R7401 T8891 T8871 arg2Of but,were
R7402 T8893 T8891 arg2Of non-methylated,but
R7403 T8893 T8892 arg1Of non-methylated,totally
R7404 T8893 T8894 arg1Of non-methylated,in
R7405 T8896 T8894 arg2Of cells,in
R7406 T8896 T8895 arg1Of cells,IRF-4-positive
R7407 T8896 T8897 arg1Of cells,(
R7408 T8899 T8898 arg1Of 4A,Figure
R7409 T8899 T8900 arg1Of 4A,and
R7410 T8900 T8897 arg2Of and,(
R7411 T8901 T8900 arg2Of B,and
R7412 T8902 T8897 arg3Of ),(
R7413 T8907 T8905 arg1Of sites,three
R7414 T8907 T8906 arg1Of sites,CpG
R7415 T8907 T8908 arg1Of sites,at
R7416 T8907 T8912 arg1Of sites,(
R7417 T8907 T8920 arg1Of sites,and
R7418 T8911 T8908 arg2Of end,at
R7419 T8911 T8909 arg1Of end,the
R7420 T8911 T8910 arg1Of end,5′
R7421 T8914 T8915 arg1Of 54,","
R7422 T8915 T8912 arg2Of ",",(
R7423 T8915 T8913 arg1Of ",",#
R7424 T8915 T8917 arg1Of ",",","
R7425 T8916 T8915 arg2Of 56,","
R7426 T8918 T8917 arg2Of 58,","
R7427 T8919 T8912 arg3Of ),(
R7428 T8920 T8924 arg1Of and,at
R7429 T8920 T8928 arg1Of and,(
R7430 T8920 T8934 arg1Of and,showed
R7431 T8923 T8920 arg2Of motifs,and
R7432 T8923 T8921 arg1Of motifs,two
R7433 T8923 T8922 arg1Of motifs,CpG
R7434 T8927 T8924 arg2Of end,at
R7435 T8927 T8925 arg1Of end,the
R7436 T8927 T8926 arg1Of end,3′
R7437 T8930 T8928 arg2Of 1,(
R7438 T8930 T8929 arg1Of 1,#
R7439 T8930 T8931 arg1Of 1,","
R7440 T8932 T8931 arg2Of 2,","
R7441 T8933 T8928 arg3Of ),(
R7442 T8934 T8903 arg1Of showed,Furthermore
R7443 T8934 T8904 arg1Of showed,","
R7444 T8937 T8934 arg2Of correlation,showed
R7445 T8937 T8935 arg1Of correlation,this
R7446 T8937 T8936 arg1Of correlation,direct
R7447 T8937 T8938 arg1Of correlation,between
R7448 T8941 T8939 arg1Of status,high
R7449 T8941 T8940 arg1Of status,methylation
R7450 T8941 T8942 arg1Of status,and
R7451 T8942 T8938 arg2Of and,between
R7452 T8943 T8942 arg2Of absence,and
R7453 T8943 T8944 arg1Of absence,of
R7454 T8946 T8944 arg2Of expression,of
R7455 T8946 T8945 arg1Of expression,IRF-4
R7456 T8948 T8947 arg2Of addition,In
R7457 T8952 T8950 arg1Of sites,two
R7458 T8952 T8951 arg1Of sites,CpG
R7459 T8952 T8953 arg1Of sites,located
R7460 T8952 T8969 arg1Of sites,are
R7461 T8952 T8971 arg1Of sites,methylated
R7462 T8953 T8954 arg1Of located,in
R7463 T8956 T8955 arg1Of NFκB,a
R7464 T8956 T8957 arg1Of NFκB,(
R7465 T8956 T8961 arg1Of NFκB,and
R7466 T8959 T8957 arg2Of 48,(
R7467 T8959 T8958 arg1Of 48,#
R7468 T8960 T8957 arg3Of ),(
R7469 T8961 T8954 arg2Of and,in
R7470 T8964 T8961 arg2Of element,and
R7471 T8964 T8962 arg1Of element,a
R7472 T8964 T8963 arg1Of element,SP1
R7473 T8964 T8965 arg1Of element,(
R7474 T8967 T8965 arg2Of 45,(
R7475 T8967 T8966 arg1Of 45,#
R7476 T8968 T8965 arg3Of ),(
R7477 T8969 T8947 arg1Of are,In
R7478 T8969 T8949 arg1Of are,","
R7479 T8971 T8969 arg2Of methylated,are
R7480 T8971 T8970 arg1Of methylated,less
R7481 T8971 T8972 arg1Of methylated,in
R7482 T8971 T8974 arg1Of methylated,than
R7483 T8973 T8972 arg2Of IRF-4-positive,in
R7484 T8975 T8974 arg2Of in,than
R7485 T8980 T8975 arg2Of number,in
R7486 T8980 T8976 arg1Of number,IRF-4-negative
R7487 T8980 T8977 arg1Of number,cells
R7488 T8980 T8978 arg1Of number,(
R7489 T8980 T8979 arg1Of number,mean
R7490 T8980 T8981 arg1Of number,of
R7491 T8983 T8981 arg2Of clones,of
R7492 T8983 T8982 arg2Of clones,methylated
R7493 T8983 T8984 arg1Of clones,:
R7494 T8985 T8986 arg1Of 1/8,versus
R7495 T8986 T8988 arg1Of versus,)
R7496 T8987 T8986 arg2Of 8/8,versus
R7497 T8990 T8989 arg1Of results,These
R7498 T8990 T8991 arg1Of results,indicate
R7499 T8993 T8991 arg2Of involvement,indicate
R7500 T8993 T8992 arg1Of involvement,the
R7501 T8993 T8994 arg1Of involvement,of
R7502 T8993 T8997 arg1Of involvement,in
R7503 T8996 T8994 arg2Of methylation,of
R7504 T8996 T8995 arg1Of methylation,CpG
R7505 T8999 T8997 arg2Of regulation,in
R7506 T8999 T8998 arg1Of regulation,the
R7507 T8999 T9000 arg1Of regulation,of
R7508 T9002 T9000 arg2Of expression,of
R7509 T9002 T9001 arg1Of expression,IRF-4
R7510 T9002 T9003 arg1Of expression,in
R7511 T9005 T9003 arg2Of cells,in
R7512 T9005 T9004 arg1Of cells,leukemic
R8042 T9707 T9706 arg1Of vitro,In
R8043 T9708 T9707 arg1Of methylation,vitro
R8044 T9708 T9709 arg1Of methylation,of
R8045 T9708 T9714 arg1Of methylation,decreases
R8046 T9713 T9709 arg2Of construct,of
R8047 T9713 T9710 arg1Of construct,an
R8048 T9713 T9711 arg1Of construct,IRF-4
R8049 T9713 T9712 arg1Of construct,promoter-reporter
R8050 T9716 T9714 arg2Of activity,decreases
R8051 T9716 T9715 arg1Of activity,its
R8052 T9718 T9717 arg1Of provide,To
R8053 T9719 T9718 arg2Of evidence,provide
R8054 T9719 T9720 arg1Of evidence,for
R8055 T9723 T9720 arg2Of effect,for
R8056 T9723 T9721 arg1Of effect,a
R8057 T9723 T9722 arg1Of effect,direct
R8058 T9723 T9724 arg1Of effect,of
R8059 T9723 T9727 arg1Of effect,on
R8060 T9726 T9724 arg2Of status,of
R8061 T9726 T9725 arg1Of status,methylational
R8062 T9730 T9727 arg2Of activity,on
R8063 T9730 T9728 arg1Of activity,IRF-4
R8064 T9730 T9729 arg1Of activity,promoter
R8065 T9731 T9718 arg1Of we,provide
R8066 T9731 T9732 arg1Of we,performed
R8067 T9732 T9717 modOf performed,To
R8068 T9732 T9740 arg1Of performed,before
R8069 T9732 T9742 arg1Of performed,after
R8070 T9735 T9732 arg2Of assays,performed
R8071 T9735 T9733 arg1Of assays,reporter
R8072 T9735 T9734 arg1Of assays,gene
R8073 T9735 T9736 arg1Of assays,with
R8074 T9739 T9736 arg2Of constructs,with
R8075 T9739 T9737 arg1Of constructs,IRF-4
R8076 T9739 T9738 arg1Of constructs,promoter
R8077 T9740 T9741 arg1Of before,and
R8078 T9742 T9741 arg2Of after,and
R8079 T9745 T9744 arg1Of vitro,in
R8080 T9746 T9740 arg2Of methylation,before
R8081 T9746 T9742 arg2Of methylation,after
R8082 T9746 T9743 arg1Of methylation,their
R8083 T9746 T9745 arg1Of methylation,vitro
R8084 T9749 T9747 arg1Of methylation,A
R8085 T9749 T9748 arg1Of methylation,complete
R8086 T9749 T9750 arg1Of methylation,of
R8087 T9749 T9753 arg1Of methylation,was
R8088 T9749 T9754 arg2Of methylation,checked
R8089 T9752 T9750 arg2Of constructs,of
R8090 T9752 T9751 arg1Of constructs,these
R8091 T9754 T9753 arg2Of checked,was
R8092 T9754 T9755 arg1Of checked,via
R8093 T9757 T9755 arg2Of assays,via
R8094 T9757 T9756 arg1Of assays,restriction
R8095 T9757 T9758 arg1Of assays,with
R8096 T9760 T9758 arg2Of endonucleases,with
R8097 T9760 T9759 arg1Of endonucleases,methylation-sensitive
R8098 T9760 T9761 arg1Of endonucleases,(
R8099 T9763 T9761 arg2Of 5A,(
R8100 T9763 T9762 arg1Of 5A,Figure
R8101 T9764 T9761 arg3Of ),(
R8102 T9767 T9768 arg1Of methylation,of
R8103 T9767 T9773 arg1Of methylation,decreased
R8104 T9771 T9768 arg2Of promoter,of
R8105 T9771 T9769 arg1Of promoter,the
R8106 T9771 T9770 arg1Of promoter,IRF-4
R8107 T9773 T9765 arg1Of decreased,Intriguingly
R8108 T9773 T9766 arg1Of decreased,","
R8109 T9773 T9772 arg1Of decreased,significantly
R8110 T9773 T9780 arg1Of decreased,by
R8111 T9775 T9773 arg2Of activity,decreased
R8112 T9775 T9774 arg1Of activity,promoter
R8113 T9775 T9776 arg1Of activity,in
R8114 T9779 T9776 arg2Of cells,in
R8115 T9779 T9777 arg1Of cells,IRF-4-positive
R8116 T9779 T9778 arg1Of cells,SD-1
R8117 T9782 T9780 arg2Of %,by
R8118 T9782 T9781 arg1Of %,85.0
R8119 T9782 T9783 arg1Of %,(
R8120 T9785 T9783 arg2Of 5B,(
R8121 T9785 T9784 arg1Of 5B,Figure
R8122 T9786 T9783 arg3Of ),(
R8123 T9789 T9787 arg1Of effect,The
R8124 T9789 T9788 arg1Of effect,silencing
R8125 T9789 T9790 arg1Of effect,of
R8126 T9789 T9793 arg1Of effect,was
R8127 T9789 T9795 arg1Of effect,restricted
R8128 T9792 T9790 arg2Of methylation,of
R8129 T9792 T9791 arg1Of methylation,CpG
R8130 T9793 T9794 arg1Of was,not
R8131 T9793 T9799 arg1Of was,","
R8132 T9793 T9800 arg1Of was,since
R8133 T9795 T9793 arg2Of restricted,was
R8134 T9795 T9796 arg1Of restricted,to
R8135 T9798 T9796 arg2Of cells,to
R8136 T9798 T9797 arg1Of cells,IRF-4-positive
R8137 T9802 T9801 arg1Of vitro,in
R8138 T9803 T9802 arg1Of methylation,vitro
R8139 T9803 T9804 arg1Of methylation,led
R8140 T9804 T9800 arg2Of led,since
R8141 T9804 T9805 arg1Of led,to
R8142 T9807 T9808 arg1Of 92.9,%
R8143 T9809 T9805 arg2Of abrogation,to
R8144 T9809 T9806 arg1Of abrogation,a
R8145 T9809 T9807 arg1Of abrogation,92.9
R8146 T9809 T9810 arg1Of abrogation,of
R8147 T9809 T9813 arg1Of abrogation,in
R8148 T9812 T9810 arg2Of activity,of
R8149 T9812 T9811 arg1Of activity,promoter
R8150 T9816 T9813 arg2Of cells,in
R8151 T9816 T9814 arg1Of cells,IRF-4-negative
R8152 T9816 T9815 arg1Of cells,Jurkat
R8153 T9816 T9817 arg1Of cells,(
R8154 T9819 T9817 arg2Of 5C,(
R8155 T9819 T9818 arg1Of 5C,Figure
R8156 T9820 T9817 arg3Of ),(
R8157 T9822 T9821 arg2Of contrast,In
R8158 T9825 T9824 arg1Of methylation,control
R8159 T9825 T9826 arg1Of methylation,of
R8160 T9825 T9830 arg1Of methylation,with
R8161 T9825 T9843 arg1Of methylation,had
R8162 T9829 T9826 arg2Of construct,of
R8163 T9829 T9827 arg1Of construct,a
R8164 T9829 T9828 arg1Of construct,reporter
R8165 T9833 T9831 arg1Of promoter,a
R8166 T9833 T9832 arg1Of promoter,different
R8167 T9833 T9834 arg1Of promoter,(
R8168 T9833 T9839 arg1Of promoter,as
R8169 T9835 T9834 arg2Of FasL,(
R8170 T9836 T9834 arg3Of ),(
R8171 T9839 T9830 arg2Of as,with
R8172 T9839 T9837 arg1Of as,as
R8173 T9839 T9838 arg1Of as,well
R8174 T9842 T9839 arg2Of vector,as
R8175 T9842 T9840 arg1Of vector,an
R8176 T9842 T9841 arg1Of vector,empty
R8177 T9843 T9821 arg1Of had,In
R8178 T9843 T9823 arg1Of had,","
R8179 T9845 T9843 arg2Of effect,had
R8180 T9845 T9844 arg1Of effect,no
R8181 T9845 T9846 arg1Of effect,on
R8182 T9849 T9846 arg2Of activity,on
R8183 T9849 T9847 arg1Of activity,the
R8184 T9849 T9848 arg1Of activity,reporter
R8185 T9849 T9850 arg1Of activity,(
R8186 T9851 T9850 arg2Of data,(
R8187 T9851 T9853 arg2Of data,shown
R8188 T9853 T9852 arg1Of shown,not
R8189 T9854 T9850 arg3Of ),(
R8190 T9856 T9855 arg1Of data,These
R8191 T9856 T9857 arg1Of data,proved
R8192 T9860 T9857 arg2Of association,proved
R8193 T9860 T9858 arg1Of association,a
R8194 T9860 T9859 arg1Of association,direct
R8195 T9860 T9861 arg1Of association,between
R8196 T9862 T9863 arg1Of methylation,and
R8197 T9863 T9861 arg2Of and,between
R8198 T9863 T9865 arg1Of and,of
R8199 T9864 T9863 arg2Of activity,and
R8200 T9868 T9865 arg2Of promoter,of
R8201 T9868 T9866 arg1Of promoter,the
R8202 T9868 T9867 arg1Of promoter,IRF-4
R8480 T10257 T10256 arg1Of expression,mRNA
R8481 T10257 T10258 arg1Of expression,of
R8482 T10257 T10264 arg1Of expression,may
R8483 T10257 T10266 arg1Of expression,be
R8484 T10257 T10267 arg2Of expression,associated
R8485 T10260 T10259 arg1Of methyltransferases,DNA
R8486 T10260 T10261 arg1Of methyltransferases,and
R8487 T10261 T10258 arg2Of and,of
R8488 T10263 T10261 arg2Of proteins,and
R8489 T10263 T10262 arg1Of proteins,methyl-CpG-binding
R8490 T10267 T10264 arg2Of associated,may
R8491 T10267 T10265 arg1Of associated,not
R8492 T10267 T10266 arg2Of associated,be
R8493 T10267 T10268 arg1Of associated,with
R8494 T10271 T10268 arg2Of methylation,with
R8495 T10271 T10269 arg1Of methylation,IRF-4
R8496 T10271 T10270 arg1Of methylation,promoter
R8497 T10273 T10274 arg1Of abundance,of
R8498 T10273 T10278 arg1Of abundance,contribute
R8499 T10275 T10276 arg1Of DNMT,and
R8500 T10276 T10274 arg2Of and,of
R8501 T10277 T10276 arg2Of MBP,and
R8502 T10278 T10272 arg2Of contribute,Since
R8503 T10278 T10279 arg1Of contribute,to
R8504 T10278 T10282 arg1Of contribute,via
R8505 T10281 T10279 arg2Of regulation,to
R8506 T10281 T10280 arg1Of regulation,promoter
R8507 T10283 T10282 arg2Of methylation,via
R8508 T10283 T10284 arg1Of methylation,(
R8509 T10285 T10284 arg2Of "25,26,28",(
R8510 T10286 T10284 arg3Of ),(
R8511 T10288 T10289 arg1Of we,studied
R8512 T10288 T10294 arg1Of we,investigate
R8513 T10289 T10272 arg1Of studied,Since
R8514 T10289 T10287 arg1Of studied,","
R8515 T10289 T10293 modOf studied,to
R8516 T10292 T10289 arg2Of expression,studied
R8517 T10292 T10290 arg1Of expression,their
R8518 T10292 T10291 arg1Of expression,mRNA
R8519 T10294 T10293 arg1Of investigate,to
R8520 T10297 T10294 arg2Of mechanism,investigate
R8521 T10297 T10295 arg1Of mechanism,a
R8522 T10297 T10296 arg1Of mechanism,possible
R8523 T10297 T10298 arg1Of mechanism,for
R8524 T10302 T10298 arg2Of differences,for
R8525 T10302 T10299 arg1Of differences,the
R8526 T10302 T10300 arg2Of differences,observed
R8527 T10302 T10301 arg1Of differences,methylation
R8528 T10302 T10303 arg1Of differences,in
R8529 T10306 T10303 arg2Of promoter,in
R8530 T10306 T10304 arg1Of promoter,the
R8531 T10306 T10305 arg1Of promoter,IRF-4
R8532 T10309 T10307 arg2Of end,To
R8533 T10309 T10308 arg1Of end,this
R8534 T10311 T10312 arg1Of we,did
R8535 T10311 T10314 arg1Of we,detect
R8536 T10314 T10307 arg1Of detect,To
R8537 T10314 T10310 arg1Of detect,","
R8538 T10314 T10312 arg2Of detect,did
R8539 T10314 T10313 arg1Of detect,not
R8540 T10317 T10316 arg1Of difference,significant
R8541 T10317 T10318 arg1Of difference,in
R8542 T10317 T10320 arg1Of difference,(
R8543 T10317 T10327 arg1Of difference,or
R8544 T10319 T10318 arg2Of DNMT,in
R8545 T10321 T10322 arg1Of DNMT1,","
R8546 T10322 T10324 arg1Of ",",and
R8547 T10323 T10322 arg2Of DNMT3A,","
R8548 T10324 T10320 arg2Of and,(
R8549 T10325 T10324 arg2Of DNMT3B,and
R8550 T10326 T10320 arg3Of ),(
R8551 T10327 T10314 arg2Of or,detect
R8552 T10327 T10315 arg1Of or,a
R8553 T10328 T10329 arg1Of MBP,(
R8554 T10330 T10331 arg1Of MBD1,","
R8555 T10331 T10333 arg1Of ",",","
R8556 T10332 T10331 arg2Of MBD2,","
R8557 T10333 T10335 arg1Of ",",and
R8558 T10334 T10333 arg2Of MBD4,","
R8559 T10335 T10329 arg2Of and,(
R8560 T10336 T10335 arg2Of MeCP,and
R8561 T10337 T10329 arg3Of ),(
R8562 T10339 T10327 arg2Of expression,or
R8563 T10339 T10328 arg1Of expression,MBP
R8564 T10339 T10338 arg1Of expression,mRNA
R8565 T10339 T10340 arg1Of expression,between
R8566 T10341 T10342 arg1Of IRF-4-positive,and
R8567 T10343 T10342 arg2Of -negative,and
R8568 T10344 T10340 arg2Of cells,between
R8569 T10344 T10341 arg1Of cells,IRF-4-positive
R8570 T10344 T10343 arg1Of cells,-negative
R8571 T10344 T10345 arg1Of cells,(
R8572 T10347 T10345 arg2Of 5D,(
R8573 T10347 T10346 arg1Of 5D,Figure
R8574 T10348 T10345 arg3Of ),(
R8575 T10350 T10349 arg2Of fact,In
R8576 T10354 T10352 arg1Of cells,all
R8577 T10354 T10353 arg2Of cells,analyzed
R8578 T10354 T10355 arg1Of cells,had
R8579 T10355 T10349 arg1Of had,In
R8580 T10355 T10351 arg1Of had,","
R8581 T10355 T10365 arg1Of had,and
R8582 T10358 T10356 arg1Of high,moderate
R8583 T10358 T10357 arg1Of high,to
R8584 T10360 T10355 arg2Of levels,had
R8585 T10360 T10358 arg1Of levels,high
R8586 T10360 T10359 arg1Of levels,mRNA
R8587 T10360 T10361 arg1Of levels,of
R8588 T10364 T10361 arg2Of DNMT/MBPs,of
R8589 T10364 T10362 arg1Of DNMT/MBPs,these
R8590 T10364 T10363 arg2Of DNMT/MBPs,tested
R8591 T10366 T10367 arg1Of differences,in
R8592 T10366 T10369 arg1Of differences,were
R8593 T10366 T10371 arg2Of differences,correlated
R8594 T10368 T10367 arg2Of expression,in
R8595 T10371 T10365 arg2Of correlated,and
R8596 T10371 T10369 arg2Of correlated,were
R8597 T10371 T10370 arg1Of correlated,not
R8598 T10371 T10372 arg1Of correlated,with
R8599 T10374 T10372 arg2Of status,with
R8600 T10374 T10373 arg1Of status,IRF-4
R8601 T10376 T10375 arg1Of results,These
R8602 T10376 T10377 arg1Of results,indicate
R8603 T10380 T10377 arg2Of cause,indicate
R8604 T10380 T10378 arg1Of cause,a
R8605 T10380 T10379 arg1Of cause,distinct
R8606 T10380 T10381 arg1Of cause,of
R8607 T10380 T10390 arg1Of cause,rather
R8608 T10384 T10381 arg2Of differences,of
R8609 T10384 T10382 arg1Of differences,the
R8610 T10384 T10383 arg1Of differences,methylation
R8611 T10384 T10385 arg1Of differences,in
R8612 T10386 T10387 arg1Of IRF-4-positive,and
R8613 T10388 T10387 arg2Of -negative,and
R8614 T10389 T10385 arg2Of cells,in
R8615 T10389 T10386 arg1Of cells,IRF-4-positive
R8616 T10389 T10388 arg1Of cells,-negative
R8617 T10390 T10391 arg1Of rather,than
R8618 T10392 T10391 arg2Of changes,than
R8619 T10392 T10393 arg1Of changes,in
R8620 T10395 T10396 arg1Of DNMT,and
R8621 T10397 T10396 arg2Of MBP,and
R8622 T10399 T10393 arg2Of transcription,in
R8623 T10399 T10394 arg1Of transcription,the
R8624 T10399 T10395 arg1Of transcription,DNMT
R8625 T10399 T10397 arg1Of transcription,MBP
R8626 T10399 T10398 arg1Of transcription,mRNA
R9224 T11348 T11346 arg1Of lesions,Many
R9225 T11348 T11347 arg1Of lesions,genetic
R9226 T11348 T11349 arg1Of lesions,are
R9227 T11348 T11350 arg2Of lesions,known
R9228 T11348 T11352 arg1Of lesions,influence
R9229 T11350 T11349 arg2Of known,are
R9230 T11352 T11350 arg3Of influence,known
R9231 T11352 T11351 arg1Of influence,to
R9232 T11354 T11352 arg2Of expression,influence
R9233 T11354 T11353 arg1Of expression,gene
R9234 T11354 T11355 arg1Of expression,of
R9235 T11358 T11355 arg2Of genes,of
R9236 T11358 T11356 arg1Of genes,tumor
R9237 T11358 T11357 arg1Of genes,suppressor
R9238 T11360 T11361 arg1Of mutations,and
R9239 T11361 T11365 arg1Of and,have
R9240 T11362 T11363 arg1Of deletions,or
R9241 T11363 T11361 arg2Of or,and
R9242 T11364 T11363 arg2Of insertions,or
R9243 T11365 T11359 arg2Of have,Whereas
R9244 T11367 T11365 arg2Of effects,have
R9245 T11367 T11366 arg1Of effects,permanent
R9246 T11370 T11369 arg1Of mechanisms,reversible
R9247 T11370 T11371 arg1Of mechanisms,are
R9248 T11371 T11359 arg1Of are,Whereas
R9249 T11371 T11368 arg1Of are,","
R9250 T11371 T11382 arg1Of are,","
R9251 T11371 T11383 arg1Of are,respectively
R9252 T11373 T11372 arg1Of methylation,gene
R9253 T11373 T11375 arg1Of methylation,or
R9254 T11375 T11371 arg2Of or,are
R9255 T11375 T11374 arg1Of or,","
R9256 T11375 T11379 arg1Of or,of
R9257 T11376 T11377 arg1Of expression,and
R9258 T11377 T11375 arg2Of and,or
R9259 T11378 T11377 arg2Of activation,and
R9260 T11381 T11379 arg2Of factors,of
R9261 T11381 T11380 arg1Of factors,transcription
R9262 T11384 T11385 arg1Of We,studied
R9263 T11384 T11398 arg1Of We,focused
R9264 T11385 T11396 arg1Of studied,and
R9265 T11388 T11385 arg2Of cause,studied
R9266 T11388 T11386 arg1Of cause,a
R9267 T11388 T11387 arg1Of cause,putative
R9268 T11388 T11389 arg1Of cause,for
R9269 T11392 T11389 arg2Of expression,for
R9270 T11392 T11390 arg1Of expression,absent
R9271 T11392 T11391 arg1Of expression,IRF-4
R9272 T11392 T11393 arg1Of expression,in
R9273 T11395 T11393 arg2Of cells,in
R9274 T11395 T11394 arg1Of cells,leukemia
R9275 T11398 T11396 arg2Of focused,and
R9276 T11398 T11397 arg1Of focused,first
R9277 T11398 T11399 arg1Of focused,on
R9278 T11401 T11399 arg2Of aberrations,on
R9279 T11401 T11400 arg1Of aberrations,genetic
R9280 T11401 T11402 arg1Of aberrations,of
R9281 T11404 T11402 arg2Of promoter,of
R9282 T11404 T11403 arg1Of promoter,the
R9283 T11405 T11406 arg1Of We,observed
R9284 T11406 T11424 arg1Of observed,:
R9285 T11409 T11406 arg2Of alterations,observed
R9286 T11409 T11407 arg1Of alterations,no
R9287 T11409 T11408 arg1Of alterations,genetic
R9288 T11409 T11410 arg1Of alterations,in
R9289 T11413 T11410 arg2Of promoter,in
R9290 T11413 T11411 arg1Of promoter,the
R9291 T11413 T11412 arg1Of promoter,IRF-4
R9292 T11413 T11414 arg1Of promoter,","
R9293 T11413 T11415 arg1Of promoter,which
R9294 T11413 T11416 arg1Of promoter,can
R9295 T11413 T11417 arg1Of promoter,account
R9296 T11417 T11416 arg2Of account,can
R9297 T11417 T11418 arg1Of account,for
R9298 T11420 T11418 arg2Of lack,for
R9299 T11420 T11419 arg1Of lack,the
R9300 T11420 T11421 arg1Of lack,of
R9301 T11423 T11421 arg2Of expression,of
R9302 T11423 T11422 arg1Of expression,IRF-4
R9303 T11429 T11425 arg1Of changes,The
R9304 T11429 T11426 arg2Of changes,detected
R9305 T11429 T11427 arg1Of changes,base
R9306 T11429 T11428 arg1Of changes,pair
R9307 T11429 T11430 arg1Of changes,at
R9308 T11429 T11437 arg1Of changes,","
R9309 T11429 T11438 arg1Of changes,at
R9310 T11429 T11446 arg1Of changes,at
R9311 T11429 T11453 arg1Of changes,are
R9312 T11432 T11430 arg2Of −1081,at
R9313 T11432 T11431 arg1Of −1081,position
R9314 T11432 T11433 arg1Of −1081,(
R9315 T11435 T11433 arg2Of substitution,(
R9316 T11435 T11434 arg1Of substitution,T→C
R9317 T11436 T11433 arg3Of ),(
R9318 T11438 T11445 arg1Of at,and
R9319 T11439 T11438 arg2Of position,at
R9320 T11439 T11440 arg1Of position,−1068
R9321 T11439 T11441 arg1Of position,(
R9322 T11443 T11441 arg2Of substitution,(
R9323 T11443 T11442 arg1Of substitution,A→C
R9324 T11444 T11441 arg3Of ),(
R9325 T11446 T11445 arg2Of at,and
R9326 T11447 T11446 arg2Of position,at
R9327 T11447 T11448 arg1Of position,−116
R9328 T11447 T11449 arg1Of position,(
R9329 T11451 T11449 arg2Of substitution,(
R9330 T11451 T11450 arg1Of substitution,A→C
R9331 T11452 T11449 arg3Of ),(
R9332 T11453 T11472 arg1Of are,whereas
R9333 T11455 T11456 arg1Of responsible,for
R9334 T11455 T11469 arg1Of responsible,and
R9335 T11458 T11456 arg2Of IRF-4-expression,for
R9336 T11458 T11457 arg1Of IRF-4-expression,absent
R9337 T11458 T11459 arg1Of IRF-4-expression,since
R9338 T11463 T11460 arg1Of mutations,the
R9339 T11463 T11461 arg1Of mutations,first
R9340 T11463 T11462 arg1Of mutations,two
R9341 T11463 T11464 arg1Of mutations,were
R9342 T11463 T11465 arg2Of mutations,found
R9343 T11465 T11459 arg2Of found,since
R9344 T11465 T11464 arg2Of found,were
R9345 T11465 T11467 arg1Of found,in
R9346 T11467 T11466 arg1Of in,both
R9347 T11468 T11467 arg2Of IRF-4-positive,in
R9348 T11470 T11469 arg2Of -negative,and
R9349 T11471 T11453 arg2Of cells,are
R9350 T11471 T11454 arg1Of cells,unlikely
R9351 T11471 T11455 arg1Of cells,responsible
R9352 T11471 T11470 arg1Of cells,-negative
R9353 T11475 T11473 arg1Of change,the
R9354 T11475 T11474 arg1Of change,latter
R9355 T11475 T11476 arg1Of change,was
R9356 T11475 T11478 arg2Of change,detected
R9357 T11475 T11487 arg1Of change,may
R9358 T11475 T11489 arg1Of change,be
R9359 T11478 T11476 arg2Of detected,was
R9360 T11478 T11477 arg1Of detected,not
R9361 T11478 T11479 arg1Of detected,consistently
R9362 T11478 T11480 arg1Of detected,in
R9363 T11478 T11486 arg1Of detected,and
R9364 T11482 T11483 arg1Of IRF-4-negative,or
R9365 T11484 T11483 arg2Of -positive,or
R9366 T11485 T11480 arg2Of cells,in
R9367 T11485 T11481 arg1Of cells,all
R9368 T11485 T11482 arg1Of cells,IRF-4-negative
R9369 T11485 T11484 arg1Of cells,-positive
R9370 T11486 T11472 arg2Of and,whereas
R9371 T11489 T11486 arg2Of be,and
R9372 T11489 T11487 arg2Of be,may
R9373 T11489 T11488 arg1Of be,thus
R9374 T11491 T11489 arg2Of polymorphism,be
R9375 T11491 T11490 arg1Of polymorphism,a
R9376 T11494 T11492 arg1Of substitutions,All
R9377 T11494 T11493 arg1Of substitutions,three
R9378 T11494 T11495 arg1Of substitutions,did
R9379 T11494 T11497 arg1Of substitutions,change
R9380 T11494 T11510 arg1Of substitutions,do
R9381 T11494 T11512 arg1Of substitutions,affect
R9382 T11497 T11495 arg2Of change,did
R9383 T11497 T11496 arg1Of change,not
R9384 T11497 T11508 arg1Of change,and
R9385 T11504 T11497 arg2Of sites,change
R9386 T11504 T11498 arg1Of sites,any
R9387 T11504 T11499 arg1Of sites,known
R9388 T11504 T11500 arg1Of sites,putative
R9389 T11504 T11501 arg1Of sites,transcription
R9390 T11504 T11502 arg1Of sites,factor
R9391 T11504 T11503 arg1Of sites,binding
R9392 T11504 T11505 arg1Of sites,(
R9393 T11506 T11505 arg2Of "30,31",(
R9394 T11507 T11505 arg3Of ),(
R9395 T11512 T11508 arg2Of affect,and
R9396 T11512 T11509 arg1Of affect,also
R9397 T11512 T11510 arg2Of affect,do
R9398 T11512 T11511 arg1Of affect,not
R9399 T11515 T11514 arg1Of sites,restriction
R9400 T11515 T11516 arg1Of sites,or
R9401 T11516 T11512 arg2Of or,affect
R9402 T11516 T11513 arg1Of or,any
R9403 T11516 T11520 arg1Of or,of
R9404 T11519 T11516 arg2Of sites,or
R9405 T11519 T11517 arg1Of sites,primer
R9406 T11519 T11518 arg1Of sites,binding
R9407 T11523 T11520 arg2Of assays,of
R9408 T11523 T11521 arg1Of assays,the
R9409 T11523 T11522 arg2Of assays,used
R9410 T11528 T11526 arg1Of variations,permanent
R9411 T11528 T11527 arg1Of variations,genetic
R9412 T11528 T11529 arg1Of variations,in
R9413 T11528 T11534 arg1Of variations,","
R9414 T11528 T11536 arg1Of variations,as
R9415 T11528 T11543 arg1Of variations,have
R9416 T11528 T11545 arg1Of variations,been
R9417 T11528 T11546 arg2Of variations,excluded
R9418 T11533 T11529 arg2Of sequence,in
R9419 T11533 T11530 arg1Of sequence,the
R9420 T11533 T11531 arg1Of sequence,IRF-4
R9421 T11533 T11532 arg1Of sequence,coding
R9422 T11536 T11535 arg1Of as,such
R9423 T11537 T11538 arg1Of deletions,or
R9424 T11538 T11536 arg2Of or,as
R9425 T11538 T11540 arg1Of or,resulting
R9426 T11539 T11538 arg2Of mutations,or
R9427 T11540 T11541 arg1Of resulting,in
R9428 T11542 T11541 arg2Of stop-codons,in
R9429 T11546 T11524 arg1Of excluded,However
R9430 T11546 T11525 arg1Of excluded,","
R9431 T11546 T11543 arg2Of excluded,have
R9432 T11546 T11544 arg1Of excluded,not
R9433 T11546 T11545 arg2Of excluded,been
R9434 T11549 T11546 arg1Of analysis,excluded
R9435 T11549 T11547 arg2Of analysis,by
R9436 T11549 T11548 arg1Of analysis,sequence
R9437 T11552 T11551 arg1Of expression,IRF-4
R9438 T11552 T11553 arg1Of expression,in
R9439 T11552 T11558 arg1Of expression,can
R9440 T11552 T11559 arg1Of expression,be
R9441 T11552 T11560 arg2Of expression,induced
R9442 T11555 T11554 arg1Of lines,cell
R9443 T11555 T11556 arg1Of lines,and
R9444 T11556 T11553 arg2Of and,in
R9445 T11557 T11556 arg2Of CML,and
R9446 T11560 T11550 arg2Of induced,Since
R9447 T11560 T11558 arg2Of induced,can
R9448 T11560 T11559 arg2Of induced,be
R9449 T11560 T11570 arg1Of induced,","
R9450 T11560 T11571 arg1Of induced,respectively
R9451 T11562 T11563 arg1Of demethylation,and
R9452 T11563 T11560 arg1Of and,induced
R9453 T11563 T11561 arg2Of and,by
R9454 T11566 T11563 arg2Of therapy,and
R9455 T11566 T11564 arg1Of therapy,successful
R9456 T11566 T11565 arg1Of therapy,IFN-α
R9457 T11566 T11567 arg1Of therapy,(
R9458 T11568 T11567 arg2Of 3,(
R9459 T11569 T11567 arg3Of ),(
R9460 T11574 T11573 arg1Of existence,the
R9461 T11574 T11575 arg1Of existence,of
R9462 T11574 T11579 arg1Of existence,seems
R9463 T11574 T11580 arg1Of existence,unlikely
R9464 T11578 T11575 arg2Of aberrations,of
R9465 T11578 T11576 arg1Of aberrations,such
R9466 T11578 T11577 arg1Of aberrations,genetic
R9467 T11579 T11550 arg1Of seems,Since
R9468 T11579 T11572 arg1Of seems,","
R9469 T11580 T11579 arg2Of unlikely,seems
R9470 T11581 T11583 arg1Of We,investigated
R9471 T11583 T11582 arg1Of investigated,then
R9472 T11587 T11586 arg1Of described,previously
R9473 T11588 T11585 arg1Of down-regulation,the
R9474 T11588 T11587 arg1Of down-regulation,described
R9475 T11588 T11589 arg1Of down-regulation,of
R9476 T11588 T11596 arg1Of down-regulation,was
R9477 T11588 T11597 arg1Of down-regulation,due
R9478 T11591 T11589 arg2Of expression,of
R9479 T11591 T11590 arg1Of expression,IRF-4
R9480 T11591 T11592 arg1Of expression,in
R9481 T11595 T11592 arg2Of leukemias,in
R9482 T11595 T11593 arg1Of leukemias,human
R9483 T11595 T11594 arg1Of leukemias,myeloid
R9484 T11596 T11583 arg2Of was,investigated
R9485 T11596 T11584 arg1Of was,whether
R9486 T11596 T11605 arg1Of was,","
R9487 T11596 T11606 arg1Of was,since
R9488 T11597 T11596 arg2Of due,was
R9489 T11597 T11598 arg1Of due,to
R9490 T11601 T11598 arg2Of hypermethylation,to
R9491 T11601 T11599 arg1Of hypermethylation,a
R9492 T11601 T11600 arg1Of hypermethylation,differential
R9493 T11601 T11602 arg1Of hypermethylation,of
R9494 T11604 T11602 arg2Of promoter,of
R9495 T11604 T11603 arg1Of promoter,the
R9496 T11609 T11607 arg1Of re-expression,the
R9497 T11609 T11608 arg2Of re-expression,presented
R9498 T11609 T11610 arg1Of re-expression,due
R9499 T11609 T11613 arg1Of re-expression,might
R9500 T11609 T11615 arg1Of re-expression,be
R9501 T11610 T11611 arg1Of due,to
R9502 T11612 T11610 arg2Of AzadC-treatment,due
R9503 T11615 T11606 arg2Of be,since
R9504 T11615 T11613 arg2Of be,might
R9505 T11615 T11614 arg1Of be,also
R9506 T11617 T11615 arg2Of result,be
R9507 T11617 T11616 arg1Of result,a
R9508 T11617 T11618 arg1Of result,of
R9509 T11619 T11618 arg2Of activation,of
R9510 T11619 T11620 arg1Of activation,of
R9511 T11623 T11620 arg2Of regulators,of
R9512 T11623 T11621 arg1Of regulators,positive
R9513 T11623 T11622 arg1Of regulators,transcriptional
R9514 T11623 T11624 arg1Of regulators,of
R9515 T11625 T11624 arg2Of IRF-4,of
R9516 T11626 T11627 arg1Of Methylation,of
R9517 T11626 T11630 arg1Of Methylation,is
R9518 T11626 T11640 arg1Of Methylation,has
R9519 T11626 T11642 arg1Of Methylation,been
R9520 T11626 T11643 arg2Of Methylation,shown
R9521 T11629 T11627 arg2Of sites,of
R9522 T11629 T11628 arg1Of sites,CpG
R9523 T11630 T11639 arg1Of is,and
R9524 T11633 T11630 arg2Of mechanism,is
R9525 T11633 T11631 arg1Of mechanism,a
R9526 T11633 T11632 arg1Of mechanism,common
R9527 T11633 T11634 arg1Of mechanism,of
R9528 T11633 T11637 arg1Of mechanism,in
R9529 T11636 T11634 arg2Of genes,of
R9530 T11636 T11635 arg1Of genes,silencing
R9531 T11638 T11637 arg2Of leukemia,in
R9532 T11643 T11639 arg2Of shown,and
R9533 T11643 T11640 arg2Of shown,has
R9534 T11643 T11641 arg1Of shown,also
R9535 T11643 T11642 arg2Of shown,been
R9536 T11643 T11644 arg1Of shown,for
R9537 T11643 T11653 arg1Of shown,for
R9538 T11644 T11652 arg1Of for,and
R9539 T11646 T11645 arg1Of IRF,another
R9540 T11646 T11647 arg1Of IRF,","
R9541 T11647 T11644 arg2Of ",",for
R9542 T11648 T11647 arg2Of IRF-7,","
R9543 T11648 T11649 arg1Of IRF-7,(
R9544 T11650 T11649 arg2Of 35,(
R9545 T11651 T11649 arg3Of ),(
R9546 T11653 T11652 arg2Of for,and
R9547 T11654 T11653 arg2Of PU.1,for
R9548 T11654 T11655 arg1Of PU.1,(
R9549 T11654 T11658 arg1Of PU.1,","
R9550 T11656 T11655 arg2Of 36,(
R9551 T11657 T11655 arg3Of ),(
R9552 T11661 T11658 arg2Of partner,","
R9553 T11661 T11659 arg1Of partner,an
R9554 T11661 T11660 arg1Of partner,interacting
R9555 T11661 T11662 arg1Of partner,of
R9556 T11663 T11662 arg2Of IRF-4,of
R9557 T11665 T11664 arg1Of elucidate,To
R9558 T11665 T11688 arg1Of elucidate,were
R9559 T11665 T11689 arg2Of elucidate,sequenced
R9560 T11667 T11665 arg2Of relevance,elucidate
R9561 T11667 T11666 arg1Of relevance,the
R9562 T11667 T11668 arg1Of relevance,of
R9563 T11670 T11668 arg2Of mechanism,of
R9564 T11670 T11669 arg1Of mechanism,this
R9565 T11670 T11671 arg1Of mechanism,for
R9566 T11673 T11671 arg2Of regulation,for
R9567 T11673 T11672 arg1Of regulation,the
R9568 T11673 T11674 arg1Of regulation,of
R9569 T11676 T11674 arg2Of expression,of
R9570 T11676 T11675 arg1Of expression,IRF-4
R9571 T11680 T11678 arg1Of cells,various
R9572 T11680 T11679 arg1Of cells,leukemic
R9573 T11680 T11681 arg1Of cells,were
R9574 T11680 T11682 arg2Of cells,treated
R9575 T11682 T11681 arg2Of treated,were
R9576 T11682 T11683 arg1Of treated,with
R9577 T11685 T11686 arg1Of agents,and
R9578 T11686 T11683 arg2Of and,with
R9579 T11686 T11684 arg1Of and,demethylating
R9580 T11687 T11686 arg2Of promoters,and
R9581 T11689 T11677 arg1Of sequenced,","
R9582 T11689 T11681 modOf sequenced,were
R9583 T11689 T11688 arg2Of sequenced,were
R9584 T11689 T11690 arg1Of sequenced,after
R9585 T11692 T11690 arg2Of treatment,after
R9586 T11692 T11691 arg1Of treatment,bisulfite
R9587 T11693 T11694 arg1Of We,found
R9588 T11697 T11696 arg1Of expression,IRF-4
R9589 T11697 T11698 arg1Of expression,could
R9590 T11697 T11700 arg1Of expression,be
R9591 T11697 T11701 arg2Of expression,connected
R9592 T11701 T11694 arg2Of connected,found
R9593 T11701 T11695 arg1Of connected,that
R9594 T11701 T11698 arg2Of connected,could
R9595 T11701 T11699 arg1Of connected,indeed
R9596 T11701 T11700 arg2Of connected,be
R9597 T11701 T11702 arg1Of connected,to
R9598 T11705 T11702 arg2Of status,to
R9599 T11705 T11703 arg1Of status,the
R9600 T11705 T11704 arg1Of status,methylation
R9601 T11705 T11706 arg1Of status,of
R9602 T11709 T11706 arg2Of motifs,of
R9603 T11709 T11707 arg1Of motifs,distinct
R9604 T11709 T11708 arg1Of motifs,CpG
R9605 T11709 T11710 arg1Of motifs,in
R9606 T11713 T11710 arg2Of promoter,in
R9607 T11713 T11711 arg1Of promoter,the
R9608 T11713 T11712 arg1Of promoter,IRF-4
R9609 T11716 T11714 arg2Of 4A,In
R9610 T11716 T11715 arg1Of 4A,Figure
R9611 T11720 T11718 arg1Of sites,those
R9612 T11720 T11719 arg1Of sites,CpG
R9613 T11720 T11721 arg1Of sites,are
R9614 T11720 T11722 arg2Of sites,shown
R9615 T11722 T11714 arg1Of shown,In
R9616 T11722 T11717 arg1Of shown,","
R9617 T11722 T11721 arg2Of shown,are
R9618 T11722 T11723 arg1Of shown,(
R9619 T11722 T11727 arg1Of shown,","
R9620 T11725 T11723 arg2Of line,(
R9621 T11725 T11724 arg1Of line,bottom
R9622 T11726 T11723 arg3Of ),(
R9623 T11728 T11722 arg3Of whose,shown
R9624 T11729 T11728 arg1Of hypermethylation,whose
R9625 T11729 T11730 arg1Of hypermethylation,may
R9626 T11729 T11731 arg1Of hypermethylation,account
R9627 T11731 T11730 arg2Of account,may
R9628 T11731 T11732 arg1Of account,for
R9629 T11734 T11732 arg2Of absence,for
R9630 T11734 T11733 arg1Of absence,the
R9631 T11734 T11735 arg1Of absence,of
R9632 T11737 T11735 arg2Of expression,of
R9633 T11737 T11736 arg1Of expression,IRF-4
R9634 T11737 T11738 arg1Of expression,in
R9635 T11741 T11738 arg2Of cells,in
R9636 T11741 T11739 arg1Of cells,the
R9637 T11741 T11740 arg1Of cells,respective
R9638 T11742 T11743 arg1Of One,of
R9639 T11742 T11749 arg1Of One,is
R9640 T11744 T11743 arg2Of them,of
R9641 T11744 T11745 arg1Of them,(
R9642 T11747 T11745 arg2Of 54,(
R9643 T11747 T11746 arg1Of 54,#
R9644 T11748 T11745 arg3Of ),(
R9645 T11749 T11759 arg1Of is,","
R9646 T11749 T11760 modOf is,indicating
R9647 T11750 T11749 arg2Of adjacent,is
R9648 T11750 T11751 arg1Of adjacent,to
R9649 T11755 T11751 arg2Of element,to
R9650 T11755 T11752 arg1Of element,an
R9651 T11755 T11753 arg2Of element,identified
R9652 T11755 T11754 arg1Of element,regulatory
R9653 T11755 T11756 arg1Of element,(
R9654 T11757 T11756 arg2Of NFκB-site,(
R9655 T11758 T11756 arg3Of ),(
R9656 T11763 T11760 arg2Of involvement,indicating
R9657 T11763 T11761 arg1Of involvement,a
R9658 T11763 T11762 arg1Of involvement,possible
R9659 T11763 T11764 arg1Of involvement,of
R9660 T11766 T11764 arg2Of site,of
R9661 T11766 T11765 arg1Of site,this
R9662 T11771 T11767 arg2Of sites,At
R9663 T11771 T11768 arg1Of sites,two
R9664 T11771 T11769 arg1Of sites,further
R9665 T11771 T11770 arg1Of sites,CpG
R9666 T11771 T11772 arg1Of sites,(
R9667 T11774 T11772 arg2Of 48,(
R9668 T11774 T11773 arg1Of 48,#
R9669 T11774 T11775 arg1Of 48,","
R9670 T11776 T11775 arg2Of 45,","
R9671 T11777 T11772 arg3Of ),(
R9672 T11780 T11778 arg1Of status,the
R9673 T11780 T11779 arg1Of status,methylation
R9674 T11780 T11781 arg1Of status,in
R9675 T11780 T11783 arg1Of status,was
R9676 T11780 T11784 arg1Of status,lower
R9677 T11782 T11781 arg2Of IRF-4-positive,in
R9678 T11783 T11767 arg1Of was,At
R9679 T11784 T11783 arg2Of lower,was
R9680 T11784 T11785 arg1Of lower,than
R9681 T11786 T11785 arg2Of that,than
R9682 T11786 T11787 arg1Of that,of
R9683 T11789 T11787 arg2Of cells,of
R9684 T11789 T11788 arg1Of cells,IRF-4-negative
R9685 T11792 T11790 arg1Of sites,These
R9686 T11792 T11791 arg1Of sites,CpG
R9687 T11792 T11793 arg1Of sites,are
R9688 T11792 T11794 arg1Of sites,located
R9689 T11792 T11807 arg1Of sites,may
R9690 T11792 T11809 arg1Of sites,play
R9691 T11793 T11805 arg1Of are,and
R9692 T11794 T11793 arg2Of located,are
R9693 T11794 T11795 arg1Of located,in
R9694 T11797 T11796 arg1Of NFκB,an
R9695 T11797 T11798 arg1Of NFκB,and
R9696 T11798 T11795 arg2Of and,in
R9697 T11801 T11798 arg2Of element,and
R9698 T11801 T11799 arg1Of element,an
R9699 T11801 T11800 arg1Of element,SP1
R9700 T11801 T11802 arg1Of element,(
R9701 T11803 T11802 arg2Of 31,(
R9702 T11804 T11802 arg3Of ),(
R9703 T11809 T11805 arg2Of play,and
R9704 T11809 T11806 arg1Of play,thus
R9705 T11809 T11807 arg2Of play,may
R9706 T11809 T11808 arg1Of play,also
R9707 T11809 T11812 arg1Of play,in
R9708 T11811 T11809 arg2Of role,play
R9709 T11811 T11810 arg1Of role,a
R9710 T11813 T11812 arg2Of regulation,in
R9711 T11813 T11814 arg1Of regulation,of
R9712 T11816 T11814 arg2Of expression,of
R9713 T11816 T11815 arg1Of expression,IRF-4
R9714 T11817 T11818 arg1Of It,has
R9715 T11817 T11819 arg1Of It,been
R9716 T11817 T11820 arg2Of It,shown
R9717 T11820 T11818 arg2Of shown,has
R9718 T11820 T11819 arg2Of shown,been
R9719 T11823 T11822 arg1Of elements,NFκB
R9720 T11823 T11824 arg1Of elements,play
R9721 T11824 T11820 arg3Of play,shown
R9722 T11824 T11821 arg1Of play,that
R9723 T11824 T11828 arg1Of play,in
R9724 T11824 T11831 arg1Of play,as
R9725 T11827 T11824 arg2Of role,play
R9726 T11827 T11825 arg1Of role,an
R9727 T11827 T11826 arg1Of role,important
R9728 T11830 T11828 arg2Of induction,in
R9729 T11830 T11829 arg1Of induction,IRF-4
R9730 T11833 T11832 arg1Of expression,IRF-4
R9731 T11833 T11834 arg1Of expression,depends
R9732 T11834 T11831 arg2Of depends,as
R9733 T11834 T11835 arg1Of depends,on
R9734 T11836 T11835 arg2Of binding,on
R9735 T11836 T11837 arg1Of binding,of
R9736 T11836 T11841 arg1Of binding,to
R9737 T11840 T11837 arg2Of c-Rel,of
R9738 T11840 T11838 arg1Of c-Rel,the
R9739 T11840 T11839 arg1Of c-Rel,transactivator
R9740 T11843 T11841 arg2Of elements,to
R9741 T11843 T11842 arg1Of elements,these
R9742 T11843 T11844 arg1Of elements,in
R9743 T11847 T11844 arg2Of promoter,in
R9744 T11847 T11845 arg1Of promoter,the
R9745 T11847 T11846 arg1Of promoter,IRF-4
R9746 T11847 T11848 arg1Of promoter,(
R9747 T11849 T11848 arg2Of "31,37",(
R9748 T11850 T11848 arg3Of ),(
R9749 T11853 T11854 arg1Of methylation,of
R9750 T11853 T11862 arg1Of methylation,inhibits
R9751 T11857 T11854 arg2Of CpG,of
R9752 T11857 T11855 arg1Of CpG,the
R9753 T11857 T11856 arg1Of CpG,central
R9754 T11857 T11858 arg1Of CpG,in
R9755 T11861 T11858 arg2Of element,in
R9756 T11861 T11859 arg1Of element,the
R9757 T11861 T11860 arg1Of element,NFκB
R9758 T11862 T11851 arg1Of inhibits,Furthermore
R9759 T11862 T11852 arg1Of inhibits,","
R9760 T11862 T11872 arg1Of inhibits,","
R9761 T11863 T11862 arg2Of binding,inhibits
R9762 T11863 T11864 arg1Of binding,of
R9763 T11868 T11864 arg2Of complexes,of
R9764 T11868 T11865 arg1Of complexes,the
R9765 T11868 T11866 arg1Of complexes,NFκB
R9766 T11868 T11867 arg1Of complexes,protein
R9767 T11868 T11869 arg1Of complexes,(
R9768 T11870 T11869 arg2Of 38,(
R9769 T11871 T11869 arg3Of ),(
R9770 T11873 T11862 arg3Of promoting,inhibits
R9771 T11875 T11873 arg2Of significance,promoting
R9772 T11875 T11874 arg1Of significance,the
R9773 T11875 T11876 arg1Of significance,of
R9774 T11880 T11876 arg2Of differences,of
R9775 T11880 T11877 arg1Of differences,the
R9776 T11880 T11878 arg2Of differences,observed
R9777 T11880 T11879 arg1Of differences,methylation
R9778 T11880 T11881 arg1Of differences,in
R9779 T11882 T11883 arg1Of IRF-4-positive,and
R9780 T11884 T11883 arg2Of -negative,and
R9781 T11885 T11881 arg2Of cells,in
R9782 T11885 T11882 arg1Of cells,IRF-4-positive
R9783 T11885 T11884 arg1Of cells,-negative
R9784 T11888 T11887 arg1Of vitro,in
R9785 T11889 T11890 arg1Of methylation,and
R9786 T11891 T11890 arg2Of reporter,and
R9787 T11893 T11886 arg2Of assays,Via
R9788 T11893 T11888 arg1Of assays,vitro
R9789 T11893 T11889 arg1Of assays,methylation
R9790 T11893 T11891 arg1Of assays,reporter
R9791 T11893 T11892 arg1Of assays,gene
R9792 T11894 T11895 arg1Of we,could
R9793 T11894 T11897 arg1Of we,appoint
R9794 T11897 T11886 modOf appoint,Via
R9795 T11897 T11895 arg2Of appoint,could
R9796 T11897 T11896 arg1Of appoint,clearly
R9797 T11897 T11904 arg1Of appoint,to
R9798 T11899 T11897 arg2Of silencing,appoint
R9799 T11899 T11898 arg1Of silencing,the
R9800 T11899 T11900 arg1Of silencing,of
R9801 T11903 T11900 arg2Of promoter,of
R9802 T11903 T11901 arg1Of promoter,the
R9803 T11903 T11902 arg1Of promoter,IRF-4
R9804 T11907 T11904 arg2Of effect,to
R9805 T11907 T11905 arg1Of effect,a
R9806 T11907 T11906 arg1Of effect,methylation
R9807 T11907 T11908 arg1Of effect,","
R9808 T11907 T11909 arg1Of effect,which
R9809 T11907 T11910 arg1Of effect,may
R9810 T11907 T11912 arg1Of effect,be
R9811 T11912 T11910 arg2Of be,may
R9812 T11912 T11911 arg1Of be,thus
R9813 T11912 T11919 arg1Of be,vivo
R9814 T11914 T11912 arg2Of mechanism,be
R9815 T11914 T11913 arg1Of mechanism,the
R9816 T11914 T11915 arg1Of mechanism,of
R9817 T11917 T11915 arg2Of deregulation,of
R9818 T11917 T11916 arg1Of deregulation,IRF-4
R9819 T11919 T11918 arg1Of vivo,in
R9820 T11922 T11920 arg1Of cause,One
R9821 T11922 T11921 arg1Of cause,possible
R9822 T11922 T11923 arg1Of cause,for
R9823 T11922 T11929 arg1Of cause,is
R9824 T11926 T11923 arg2Of methylation,for
R9825 T11926 T11924 arg1Of methylation,the
R9826 T11926 T11925 arg1Of methylation,aberrant
R9827 T11926 T11927 arg1Of methylation,in
R9828 T11928 T11927 arg2Of tumorigenesis,in
R9829 T11932 T11929 arg2Of level,is
R9830 T11932 T11930 arg1Of level,an
R9831 T11932 T11931 arg2Of level,increased
R9832 T11932 T11933 arg1Of level,of
R9833 T11932 T11935 arg1Of level,during
R9834 T11934 T11933 arg2Of DNMTs,of
R9835 T11938 T11935 arg2Of process,during
R9836 T11938 T11936 arg1Of process,the
R9837 T11938 T11937 arg1Of process,pathogenetic
R9838 T11940 T11941 arg1Of colon,","
R9839 T11941 T11943 arg1Of ",",and
R9840 T11942 T11941 arg2Of lung,","
R9841 T11943 T11939 arg2Of and,In
R9842 T11945 T11943 arg2Of malignancies,and
R9843 T11945 T11944 arg1Of malignancies,hematologic
R9844 T11947 T11948 arg1Of overexpression,of
R9845 T11947 T11955 arg1Of overexpression,has
R9846 T11947 T11956 arg1Of overexpression,been
R9847 T11947 T11957 arg2Of overexpression,detected
R9848 T11949 T11948 arg2Of DNMT1,of
R9849 T11949 T11950 arg1Of DNMT1,","
R9850 T11953 T11950 arg2Of DNMT,","
R9851 T11953 T11951 arg1Of DNMT,a
R9852 T11953 T11952 arg1Of DNMT,maintenance
R9853 T11957 T11939 arg1Of detected,In
R9854 T11957 T11946 arg1Of detected,","
R9855 T11957 T11954 arg1Of detected,","
R9856 T11957 T11955 arg2Of detected,has
R9857 T11957 T11956 arg2Of detected,been
R9858 T11957 T11958 arg1Of detected,(
R9859 T11959 T11958 arg2Of 39–41,(
R9860 T11960 T11958 arg3Of ),(
R9861 T11963 T11964 arg1Of it,has
R9862 T11963 T11965 arg1Of it,been
R9863 T11963 T11966 arg2Of it,shown
R9864 T11966 T11961 arg1Of shown,Furthermore
R9865 T11966 T11962 arg1Of shown,","
R9866 T11966 T11964 arg2Of shown,has
R9867 T11966 T11965 arg2Of shown,been
R9868 T11969 T11968 arg1Of cells,CML
R9869 T11969 T11970 arg1Of cells,in
R9870 T11969 T11974 arg1Of cells,exhibited
R9871 T11973 T11970 arg2Of phase,in
R9872 T11973 T11971 arg1Of phase,the
R9873 T11973 T11972 arg1Of phase,acute
R9874 T11974 T11966 arg3Of exhibited,shown
R9875 T11974 T11967 arg1Of exhibited,that
R9876 T11974 T11982 arg1Of exhibited,","
R9877 T11974 T11983 arg1Of exhibited,while
R9878 T11976 T11974 arg2Of levels,exhibited
R9879 T11976 T11975 arg1Of levels,elevated
R9880 T11976 T11977 arg1Of levels,of
R9881 T11981 T11977 arg2Of DNMTs,of
R9882 T11981 T11978 arg1Of DNMTs,the
R9883 T11981 T11979 arg1Of DNMTs,three
R9884 T11981 T11980 arg2Of DNMTs,known
R9885 T11985 T11984 arg1Of cells,CML
R9886 T11985 T11986 arg1Of cells,in
R9887 T11985 T11989 arg1Of cells,expressed
R9888 T11988 T11986 arg2Of phase,in
R9889 T11988 T11987 arg1Of phase,chronic
R9890 T11989 T11983 arg2Of expressed,while
R9891 T11989 T11994 arg1Of expressed,if
R9892 T11991 T11989 arg2Of levels,expressed
R9893 T11991 T11990 arg1Of levels,normal
R9894 T11991 T11992 arg1Of levels,of
R9895 T11993 T11992 arg2Of DNMTs,of
R9896 T11995 T11994 arg2Of compared,if
R9897 T11995 T11996 arg1Of compared,with
R9898 T12000 T11996 arg2Of cells,with
R9899 T12000 T11997 arg1Of cells,normal
R9900 T12000 T11998 arg1Of cells,bone
R9901 T12000 T11999 arg1Of cells,marrow
R9902 T12000 T12001 arg1Of cells,(
R9903 T12002 T12001 arg2Of 25,(
R9904 T12003 T12001 arg3Of ),(
R9905 T12008 T12006 arg1Of correlation,a
R9906 T12008 T12007 arg1Of correlation,positive
R9907 T12008 T12009 arg1Of correlation,between
R9908 T12008 T12017 arg1Of correlation,has
R9909 T12008 T12018 arg1Of correlation,been
R9910 T12008 T12019 arg2Of correlation,detected
R9911 T12012 T12010 arg1Of levels,DNMT1
R9912 T12012 T12011 arg1Of levels,expression
R9913 T12012 T12013 arg1Of levels,and
R9914 T12013 T12009 arg2Of and,between
R9915 T12014 T12013 arg2Of hypermethylation,and
R9916 T12014 T12015 arg1Of hypermethylation,of
R9917 T12016 T12015 arg2Of p15INK4b,of
R9918 T12019 T12004 arg1Of detected,Interestingly
R9919 T12019 T12005 arg1Of detected,","
R9920 T12019 T12017 arg2Of detected,has
R9921 T12019 T12018 arg2Of detected,been
R9922 T12019 T12020 arg1Of detected,in
R9923 T12021 T12020 arg2Of AML,in
R9924 T12021 T12022 arg1Of AML,(
R9925 T12023 T12022 arg2Of 25,(
R9926 T12024 T12022 arg3Of ),(
R9927 T12027 T12025 arg2Of work,In
R9928 T12027 T12026 arg1Of work,this
R9929 T12029 T12030 arg1Of we,did
R9930 T12029 T12032 arg1Of we,detect
R9931 T12032 T12025 arg1Of detect,In
R9932 T12032 T12028 arg1Of detect,","
R9933 T12032 T12030 arg2Of detect,did
R9934 T12032 T12031 arg1Of detect,not
R9935 T12032 T12042 arg1Of detect,","
R9936 T12032 T12043 modOf detect,making
R9937 T12036 T12032 arg2Of differences,detect
R9938 T12036 T12033 arg1Of differences,significant
R9939 T12036 T12034 arg1Of differences,mRNA
R9940 T12036 T12035 arg1Of differences,expression
R9941 T12036 T12037 arg1Of differences,of
R9942 T12039 T12040 arg1Of DNMT,or
R9943 T12040 T12037 arg2Of or,of
R9944 T12040 T12038 arg2Of or,selected
R9945 T12041 T12040 arg2Of MBP,or
R9946 T12044 T12043 arg2Of it,making
R9947 T12047 T12043 arg3Of cause,making
R9948 T12047 T12045 arg1Of cause,an
R9949 T12047 T12046 arg1Of cause,unlikely
R9950 T12047 T12048 arg1Of cause,for
R9951 T12051 T12050 arg2Of methylation,observed
R9952 T12051 T12052 arg1Of methylation,and
R9953 T12052 T12048 arg2Of and,for
R9954 T12052 T12049 arg1Of and,the
R9955 T12052 T12057 arg1Of and,in
R9956 T12056 T12052 arg2Of differences,and
R9957 T12056 T12053 arg1Of differences,thus
R9958 T12056 T12054 arg1Of differences,IRF-4
R9959 T12056 T12055 arg1Of differences,expression
R9960 T12059 T12057 arg2Of cells,in
R9961 T12059 T12058 arg1Of cells,leukemia
R9962 T12061 T12060 arg1Of finding,The
R9963 T12061 T12070 arg1Of finding,might
R9964 T12061 T12071 arg1Of finding,represent
R9965 T12064 T12063 arg1Of expression,IRF-4
R9966 T12064 T12065 arg1Of expression,is
R9967 T12064 T12066 arg2Of expression,silenced
R9968 T12066 T12061 arg2Of silenced,finding
R9969 T12066 T12062 arg1Of silenced,that
R9970 T12066 T12065 arg2Of silenced,is
R9971 T12069 T12066 arg1Of hypermethylation,silenced
R9972 T12069 T12067 arg2Of hypermethylation,by
R9973 T12069 T12068 arg1Of hypermethylation,promoter
R9974 T12071 T12070 arg2Of represent,might
R9975 T12073 T12071 arg2Of mechanism,represent
R9976 T12073 T12072 arg1Of mechanism,a
R9977 T12073 T12074 arg1Of mechanism,that
R9978 T12073 T12075 arg1Of mechanism,accounts
R9979 T12075 T12076 arg1Of accounts,for
R9980 T12079 T12078 arg1Of observed,previously
R9981 T12080 T12076 arg2Of loss,for
R9982 T12080 T12077 arg1Of loss,the
R9983 T12080 T12079 arg1Of loss,observed
R9984 T12080 T12081 arg1Of loss,of
R9985 T12083 T12081 arg2Of expression,of
R9986 T12083 T12082 arg1Of expression,IRF-4
R9987 T12083 T12084 arg1Of expression,in
R9988 T12085 T12084 arg2Of CML,in
R9989 T12090 T12088 arg1Of trials,several
R9990 T12090 T12089 arg1Of trials,clinical
R9991 T12090 T12091 arg1Of trials,with
R9992 T12090 T12099 arg1Of trials,demonstrated
R9993 T12093 T12092 arg1Of patients,leukemia
R9994 T12093 T12094 arg1Of patients,and
R9995 T12094 T12091 arg2Of and,with
R9996 T12095 T12094 arg2Of patients,and
R9997 T12095 T12096 arg1Of patients,with
R9998 T12098 T12096 arg2Of syndromes,with
R9999 T12098 T12097 arg1Of syndromes,myelodysplastic
R10000 T12099 T12086 arg1Of demonstrated,Indeed
R10001 T12099 T12087 arg1Of demonstrated,","
R10002 T12103 T12099 arg2Of benefit,demonstrated
R10003 T12103 T12100 arg1Of benefit,the
R10004 T12103 T12101 arg1Of benefit,potential
R10005 T12103 T12102 arg1Of benefit,clinical
R10006 T12103 T12104 arg1Of benefit,of
R10007 T12106 T12104 arg2Of treatment,of
R10008 T12106 T12105 arg1Of treatment,a
R10009 T12106 T12107 arg1Of treatment,with
R10010 T12109 T12107 arg2Of agents,with
R10011 T12109 T12108 arg1Of agents,demethylating
R10012 T12109 T12110 arg1Of agents,(
R10013 T12111 T12110 arg2Of 42–45,(
R10014 T12112 T12110 arg3Of ),(
R10015 T12114 T12113 arg1Of expression,The
R10016 T12114 T12115 arg1Of expression,of
R10017 T12114 T12128 arg1Of expression,is
R10018 T12114 T12129 arg1Of expression,impaired
R10019 T12117 T12116 arg1Of IRF,another
R10020 T12117 T12118 arg1Of IRF,","
R10021 T12118 T12115 arg2Of ",",of
R10022 T12123 T12118 arg2Of protein,","
R10023 T12123 T12119 arg1Of protein,IFN
R10024 T12123 T12120 arg1Of protein,consensus
R10025 T12123 T12121 arg1Of protein,sequence
R10026 T12123 T12122 arg1Of protein,binding
R10027 T12123 T12124 arg1Of protein,(
R10028 T12125 T12124 arg2Of ICSBP/IRF-8,(
R10029 T12126 T12124 arg3Of ),(
R10030 T12128 T12127 arg1Of is,","
R10031 T12129 T12128 arg2Of impaired,is
R10032 T12129 T12130 arg1Of impaired,in
R10033 T12134 T12130 arg2Of CML,in
R10034 T12134 T12131 arg1Of CML,myeloid
R10035 T12134 T12132 arg1Of CML,leukemias
R10036 T12134 T12133 arg1Of CML,especially
R10037 T12134 T12135 arg1Of CML,(
R10038 T12136 T12135 arg2Of "27,46,47",(
R10039 T12137 T12135 arg3Of ),(
R10040 T12140 T12139 arg2Of contrast,in
R10041 T12140 T12141 arg1Of contrast,to
R10042 T12142 T12141 arg2Of IRF-4,to
R10043 T12145 T12144 arg1Of loss,the
R10044 T12145 T12146 arg1Of loss,of
R10045 T12145 T12149 arg1Of loss,could
R10046 T12145 T12151 arg1Of loss,be
R10047 T12145 T12152 arg2Of loss,reverted
R10048 T12148 T12146 arg2Of IRF,of
R10049 T12148 T12147 arg1Of IRF,this
R10050 T12152 T12149 arg2Of reverted,could
R10051 T12152 T12150 arg1Of reverted,not
R10052 T12152 T12151 arg2Of reverted,be
R10053 T12152 T12153 arg1Of reverted,in
R10054 T12152 T12166 arg1Of reverted,by
R10055 T12152 T12174 arg1Of reverted,and
R10056 T12156 T12153 arg2Of lines,in
R10057 T12156 T12154 arg1Of lines,ICSBP-negative
R10058 T12156 T12155 arg1Of lines,cell
R10059 T12156 T12157 arg1Of lines,(
R10060 T12158 T12159 arg1Of EM-2,","
R10061 T12159 T12161 arg1Of ",",","
R10062 T12160 T12159 arg2Of CML-T1,","
R10063 T12161 T12163 arg1Of ",",and
R10064 T12162 T12161 arg2Of K-562,","
R10065 T12163 T12157 arg2Of and,(
R10066 T12164 T12163 arg2Of LAMA-84,and
R10067 T12165 T12157 arg3Of ),(
R10068 T12167 T12166 arg2Of treatment,by
R10069 T12167 T12168 arg1Of treatment,with
R10070 T12169 T12168 arg2Of AzadC,with
R10071 T12169 T12170 arg1Of AzadC,(
R10072 T12171 T12170 arg2Of Figure,(
R10073 T12171 T12172 arg1Of Figure,6
R10074 T12173 T12170 arg3Of ),(
R10075 T12174 T12138 arg1Of and,But
R10076 T12174 T12139 arg1Of and,in
R10077 T12174 T12143 arg1Of and,","
R10078 T12175 T12176 arg1Of AzadC,has
R10079 T12176 T12174 arg2Of has,and
R10080 T12176 T12179 arg1Of has,on
R10081 T12178 T12176 arg2Of effect,has
R10082 T12178 T12177 arg1Of effect,no
R10083 T12181 T12179 arg2Of levels,on
R10084 T12181 T12180 arg1Of levels,ICSBP
R10085 T12181 T12182 arg1Of levels,in
R10086 T12185 T12182 arg2Of cells,in
R10087 T12185 T12183 arg1Of cells,ICSBP-positive
R10088 T12185 T12184 arg1Of cells,U-937
R10089 T12185 T12186 arg1Of cells,(
R10090 T12187 T12186 arg2Of Figure,(
R10091 T12187 T12188 arg1Of Figure,6
R10092 T12189 T12186 arg3Of ),(
R10093 T12191 T12190 arg1Of data,These
R10094 T12191 T12192 arg1Of data,suggest
R10095 T12196 T12192 arg2Of mechanism,suggest
R10096 T12196 T12193 arg1Of mechanism,a
R10097 T12196 T12194 arg1Of mechanism,distinct
R10098 T12196 T12195 arg1Of mechanism,regulatory
R10099 T12196 T12197 arg1Of mechanism,for
R10100 T12200 T12197 arg2Of IRFs,for
R10101 T12200 T12198 arg1Of IRFs,these
R10102 T12200 T12199 arg1Of IRFs,two
R10103 T12201 T12202 arg1Of IRF-4,","
R10104 T12201 T12203 arg1Of IRF-4,similar
R10105 T12203 T12204 arg1Of similar,to
R10106 T12210 T12204 arg2Of genes,to
R10107 T12210 T12205 arg1Of genes,many
R10108 T12210 T12206 arg1Of genes,other
R10109 T12210 T12207 arg1Of genes,classical
R10110 T12210 T12208 arg1Of genes,tumor
R10111 T12210 T12209 arg1Of genes,suppressor
R10112 T12211 T12212 arg1Of p15INK4b,","
R10113 T12212 T12214 arg1Of ",",or
R10114 T12213 T12212 arg2Of p16INK4a,","
R10115 T12214 T12201 arg1Of or,IRF-4
R10116 T12214 T12217 arg1Of or,may
R10117 T12214 T12219 arg1Of or,be
R10118 T12215 T12214 arg2Of p53,or
R10119 T12219 T12216 arg1Of be,","
R10120 T12219 T12217 arg2Of be,may
R10121 T12219 T12218 arg1Of be,thus
R10122 T12221 T12219 arg2Of subject,be
R10123 T12221 T12220 arg1Of subject,a
R10124 T12221 T12222 arg1Of subject,of
R10125 T12221 T12224 arg1Of subject,in
R10126 T12221 T12233 arg1Of subject,","
R10127 T12221 T12234 arg1Of subject,which
R10128 T12221 T12235 arg1Of subject,might
R10129 T12221 T12236 arg1Of subject,contribute
R10130 T12223 T12222 arg2Of alterations,of
R10131 T12228 T12224 arg2Of status,in
R10132 T12228 T12225 arg1Of status,the
R10133 T12228 T12226 arg1Of status,promoter
R10134 T12228 T12227 arg1Of status,methylation
R10135 T12228 T12229 arg1Of status,leading
R10136 T12229 T12230 arg1Of leading,to
R10137 T12232 T12230 arg2Of changes,to
R10138 T12232 T12231 arg1Of changes,expression
R10139 T12236 T12235 arg2Of contribute,might
R10140 T12236 T12237 arg1Of contribute,to
R10141 T12239 T12240 arg1Of initiation,and/or
R10142 T12240 T12237 arg2Of and/or,to
R10143 T12240 T12238 arg1Of and/or,the
R10144 T12240 T12242 arg1Of and/or,of
R10145 T12241 T12240 arg2Of progression,and/or
R10146 T12243 T12242 arg2Of cancer,of
R10147 T12249 T12246 arg1Of diversity,the
R10148 T12249 T12247 arg1Of diversity,obvious
R10149 T12249 T12248 arg1Of diversity,functional
R10150 T12249 T12250 arg1Of diversity,of
R10151 T12249 T12252 arg1Of diversity,remains
R10152 T12249 T12253 arg1Of diversity,remarkable
R10153 T12249 T12255 arg1Of diversity,can
R10154 T12249 T12257 arg1Of diversity,be
R10155 T12249 T12259 arg2Of diversity,explained
R10156 T12251 T12250 arg2Of IRF-4,of
R10157 T12252 T12254 arg1Of remains,and
R10158 T12253 T12252 arg2Of remarkable,remains
R10159 T12254 T12244 arg1Of and,Still
R10160 T12254 T12245 arg1Of and,","
R10161 T12259 T12254 arg2Of explained,and
R10162 T12259 T12255 arg2Of explained,can
R10163 T12259 T12256 arg1Of explained,not
R10164 T12259 T12257 arg2Of explained,be
R10165 T12259 T12258 arg1Of explained,fully
R10166 T12265 T12259 arg1Of status,explained
R10167 T12265 T12260 arg2Of status,by
R10168 T12265 T12261 arg1Of status,the
R10169 T12265 T12262 arg1Of status,IRF-4
R10170 T12265 T12263 arg1Of status,promoter
R10171 T12265 T12264 arg1Of status,methylation
R10172 T12267 T12266 arg2Of example,For
R10173 T12269 T12270 arg1Of IRF-4,is
R10174 T12269 T12272 arg2Of IRF-4,known
R10175 T12272 T12266 arg1Of known,For
R10176 T12272 T12268 arg1Of known,","
R10177 T12272 T12270 arg2Of known,is
R10178 T12272 T12271 arg1Of known,primarily
R10179 T12272 T12273 arg1Of known,for
R10180 T12276 T12273 arg2Of features,for
R10181 T12276 T12274 arg1Of features,its
R10182 T12276 T12275 arg1Of features,oncogenic
R10183 T12279 T12277 arg2Of myeloma,In
R10184 T12279 T12278 arg1Of myeloma,multiple
R10185 T12279 T12280 arg1Of myeloma,(
R10186 T12281 T12280 arg2Of MM,(
R10187 T12282 T12280 arg3Of ),(
R10188 T12284 T12283 arg1Of translocation,a
R10189 T12284 T12285 arg1Of translocation,on
R10190 T12284 T12288 arg1Of translocation,was
R10191 T12284 T12289 arg2Of translocation,reported
R10192 T12284 T12291 arg1Of translocation,lead
R10193 T12287 T12285 arg2Of 14q,on
R10194 T12287 T12286 arg1Of 14q,chromosome
R10195 T12289 T12277 arg1Of reported,In
R10196 T12289 T12288 arg2Of reported,was
R10197 T12289 T12304 modOf reported,resulting
R10198 T12291 T12289 arg3Of lead,reported
R10199 T12291 T12290 arg1Of lead,to
R10200 T12291 T12292 arg1Of lead,to
R10201 T12295 T12292 arg2Of gene,to
R10202 T12295 T12293 arg1Of gene,a
R10203 T12295 T12294 arg1Of gene,fusion
R10204 T12295 T12296 arg1Of gene,of
R10205 T12298 T12297 arg1Of heavy-chain,immunoglobulin
R10206 T12298 T12299 arg1Of heavy-chain,(
R10207 T12298 T12302 arg1Of heavy-chain,and
R10208 T12300 T12299 arg2Of IgH,(
R10209 T12301 T12299 arg3Of ),(
R10210 T12302 T12296 arg2Of and,of
R10211 T12303 T12302 arg2Of IRF-4,and
R10212 T12304 T12305 arg1Of resulting,in
R10213 T12308 T12305 arg2Of overexpression,in
R10214 T12308 T12306 arg1Of overexpression,a
R10215 T12308 T12307 arg1Of overexpression,subsequent
R10216 T12308 T12309 arg1Of overexpression,of
R10217 T12310 T12309 arg2Of IRF-4,of
R10218 T12310 T12311 arg1Of IRF-4,(
R10219 T12312 T12311 arg2Of "48,49",(
R10220 T12313 T12311 arg3Of ),(
R10221 T12315 T12314 arg2Of addition,In
R10222 T12319 T12317 arg1Of expression,abundant
R10223 T12319 T12318 arg1Of expression,IRF-4
R10224 T12319 T12320 arg1Of expression,was
R10225 T12319 T12321 arg2Of expression,found
R10226 T12319 T12323 arg1Of expression,be
R10227 T12321 T12314 arg1Of found,In
R10228 T12321 T12316 arg1Of found,","
R10229 T12321 T12320 arg2Of found,was
R10230 T12323 T12321 arg3Of be,found
R10231 T12323 T12322 arg1Of be,to
R10232 T12325 T12323 arg2Of marker,be
R10233 T12325 T12324 arg1Of marker,a
R10234 T12325 T12326 arg1Of marker,for
R10235 T12328 T12326 arg2Of subsets,for
R10236 T12328 T12327 arg1Of subsets,various
R10237 T12328 T12329 arg1Of subsets,of
R10238 T12328 T12331 arg1Of subsets,","
R10239 T12328 T12333 arg1Of subsets,as
R10240 T12330 T12329 arg2Of lymphomas,of
R10241 T12333 T12332 arg1Of as,such
R10242 T12337 T12334 arg1Of lymphomas,diffuse
R10243 T12337 T12335 arg1Of lymphomas,large
R10244 T12337 T12336 arg1Of lymphomas,B-cell
R10245 T12337 T12338 arg1Of lymphomas,","
R10246 T12338 T12343 arg1Of ",",and
R10247 T12341 T12338 arg2Of lymphoma,","
R10248 T12341 T12339 arg1Of lymphoma,primary
R10249 T12341 T12340 arg1Of lymphoma,effusion
R10250 T12343 T12342 arg1Of and,","
R10251 T12343 T12348 arg1Of and,and
R10252 T12346 T12343 arg2Of lymphoma,and
R10253 T12346 T12344 arg1Of lymphoma,marginal
R10254 T12346 T12345 arg1Of lymphoma,zone
R10255 T12348 T12333 arg2Of and,as
R10256 T12348 T12347 arg1Of and,","
R10257 T12351 T12348 arg2Of leukemia,and
R10258 T12351 T12349 arg1Of leukemia,adult
R10259 T12351 T12350 arg1Of leukemia,T-cell
R10260 T12351 T12352 arg1Of leukemia,(
R10261 T12353 T12352 arg2Of "11,31,50–52",(
R10262 T12354 T12352 arg3Of ),(
R10263 T12355 T12356 arg1Of This,draws
R10264 T12359 T12358 arg1Of complex,more
R10265 T12360 T12356 arg2Of picture,draws
R10266 T12360 T12357 arg1Of picture,a
R10267 T12360 T12359 arg1Of picture,complex
R10268 T12360 T12361 arg1Of picture,of
R10269 T12363 T12361 arg2Of role,of
R10270 T12363 T12362 arg1Of role,the
R10271 T12363 T12364 arg1Of role,of
R10272 T12365 T12364 arg2Of IRF-4,of
R10273 T12366 T12367 arg1Of Down-regulation,of
R10274 T12366 T12369 arg1Of Down-regulation,may
R10275 T12366 T12370 arg1Of Down-regulation,promote
R10276 T12368 T12367 arg2Of IRF-4,of
R10277 T12370 T12369 arg2Of promote,may
R10278 T12370 T12372 arg1Of promote,in
R10279 T12371 T12370 arg2Of leukemogenesis,promote
R10280 T12375 T12372 arg2Of context,in
R10281 T12375 T12373 arg1Of context,myeloid
R10282 T12375 T12374 arg1Of context,cell
R10283 T12375 T12376 arg1Of context,(
R10284 T12375 T12379 arg1Of context,","
R10285 T12375 T12380 arg1Of context,which
R10286 T12375 T12381 arg1Of context,was
R10287 T12375 T12383 arg2Of context,confirmed
R10288 T12377 T12376 arg2Of 3,(
R10289 T12378 T12376 arg3Of ),(
R10290 T12383 T12381 arg2Of confirmed,was
R10291 T12383 T12382 arg1Of confirmed,recently
R10292 T12383 T12384 arg1Of confirmed,in
R10293 T12383 T12393 arg1Of confirmed,","
R10294 T12383 T12394 arg1Of confirmed,while
R10295 T12389 T12384 arg2Of mice,in
R10296 T12389 T12385 arg1Of mice,IRF-4−/−
R10297 T12389 T12386 arg1Of mice,ICSBP−/−
R10298 T12389 T12387 arg1Of mice,double
R10299 T12389 T12388 arg1Of mice,knock-out
R10300 T12389 T12390 arg1Of mice,(
R10301 T12391 T12390 arg2Of 53,(
R10302 T12392 T12390 arg3Of ),(
R10303 T12396 T12395 arg1Of up-regulation,IRF-4
R10304 T12396 T12397 arg1Of up-regulation,may
R10305 T12396 T12398 arg1Of up-regulation,induce
R10306 T12398 T12394 arg2Of induce,while
R10307 T12398 T12397 arg2Of induce,may
R10308 T12398 T12402 arg1Of induce,in
R10309 T12401 T12398 arg2Of advantage,induce
R10310 T12401 T12399 arg1Of advantage,a
R10311 T12401 T12400 arg1Of advantage,growth
R10312 T12403 T12404 arg1Of lymphomas,or
R10313 T12404 T12402 arg2Of or,in
R10314 T12405 T12404 arg2Of MM,or
R10315 T12405 T12406 arg1Of MM,(
R10316 T12407 T12406 arg2Of 48,(
R10317 T12408 T12406 arg3Of ),(
R10318 T12409 T12410 arg1Of Taken,together
R10319 T12413 T12412 arg1Of data,our
R10320 T12413 T12414 arg1Of data,suggest
R10321 T12414 T12409 modOf suggest,Taken
R10322 T12414 T12411 arg1Of suggest,","
R10323 T12418 T12416 arg1Of methylation,IRF-4
R10324 T12418 T12417 arg1Of methylation,promoter
R10325 T12418 T12419 arg1Of methylation,regulates
R10326 T12419 T12415 arg1Of regulates,that
R10327 T12419 T12423 arg1Of regulates,and
R10328 T12421 T12419 arg2Of expression,regulates
R10329 T12421 T12420 arg1Of expression,IRF-4
R10330 T12423 T12414 arg2Of and,suggest
R10331 T12423 T12422 arg1Of and,","
R10332 T12424 T12423 arg2Of that,and
R10333 T12426 T12425 arg1Of expression,aberrant
R10334 T12426 T12427 arg1Of expression,of
R10335 T12426 T12429 arg1Of expression,in
R10336 T12426 T12434 arg1Of expression,may
R10337 T12426 T12435 arg1Of expression,be
R10338 T12428 T12427 arg2Of IRF-4,of
R10339 T12431 T12429 arg2Of types,in
R10340 T12431 T12430 arg1Of types,certain
R10341 T12431 T12432 arg1Of types,of
R10342 T12433 T12432 arg2Of leukemia,of
R10343 T12435 T12424 arg2Of be,that
R10344 T12435 T12434 arg2Of be,may
R10345 T12437 T12435 arg2Of consequence,be
R10346 T12437 T12436 arg1Of consequence,a
R10347 T12437 T12438 arg1Of consequence,of
R10348 T12441 T12438 arg2Of hypermethylation,of
R10349 T12441 T12439 arg1Of hypermethylation,IRF-4
R10350 T12441 T12440 arg1Of hypermethylation,promoter
R2438 T3062 T3063 arg1Of Sequencing,of
R2439 T3066 T3063 arg2Of promoter,of
R2440 T3066 T3064 arg1Of promoter,the
R2441 T3066 T3065 arg1Of promoter,IRF-4
R2442 T3068 T3067 arg2Of analysis,For
R2443 T3068 T3069 arg1Of analysis,of
R2444 T3073 T3069 arg2Of region,of
R2445 T3073 T3070 arg1Of region,the
R2446 T3073 T3071 arg1Of region,IRF-4
R2447 T3073 T3072 arg1Of region,promoter
R2448 T3073 T3074 arg1Of region,for
R2449 T3076 T3074 arg2Of aberrations,for
R2450 T3076 T3075 arg1Of aberrations,permanent
R2451 T3076 T3078 arg1Of aberrations,as
R2452 T3078 T3077 arg1Of as,such
R2453 T3079 T3080 arg1Of insertions/deletions,or
R2454 T3080 T3078 arg2Of or,as
R2308 T2908 T2907 arg2Of Germany,","
R2310 T2913 T2911 arg2Of cells,indicated
R2311 T2913 T2914 arg1Of cells,were
R2312 T2913 T2915 arg2Of cells,treated
R2313 T2915 T2910 arg1Of treated,When
R2314 T2915 T2911 modOf treated,indicated
R2315 T2915 T2912 arg1Of treated,","
R2316 T2915 T2914 arg2Of treated,were
R2317 T2915 T2916 arg1Of treated,with
R2318 T2915 T2926 arg1Of treated,(
R2319 T2915 T2933 arg1Of treated,for
R2320 T2917 T2918 arg1Of 5-aza-2-deoxycytidine,(

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T10406 21244-21248 Antecedent denotes MBD2
T10407 21250-21254 Antecedent denotes MBD4
T10408 21259-21263 Antecedent denotes MeCP
T10409 21625-21633 Anaphor denotes the DNMT
T10410 21638-21641 Anaphor denotes MBP
T386 332-343 Anaphor denotes other genes
T387 378-408 Antecedent denotes interferon regulatory factor 4
T10400 21401-21418 Anaphor denotes these tested DNMT
T10401 21204-21209 Antecedent denotes DNMT1
T10402 21211-21217 Antecedent denotes DNMT3A
T10403 21222-21228 Antecedent denotes DNMT3B
T10404 21419-21423 Anaphor denotes MBPs
T10405 21238-21242 Antecedent denotes MBD1
T12442 24650-24664 Anaphor denotes these elements
T12443 24524-24537 Antecedent denotes NFκB elements
T12444 26494-26502 Anaphor denotes this IRF
T12445 26342-26380 Antecedent denotes IFN consensus sequence binding protein
R8634 T10409 T10401 boundBy the DNMT,DNMT1
R8635 T10409 T10402 boundBy the DNMT,DNMT3A
R8636 T10409 T10403 boundBy the DNMT,DNMT3B
R8637 T10410 T10405 boundBy MBP,MBD1
R8638 T10410 T10406 boundBy MBP,MBD2
R8639 T10410 T10407 boundBy MBP,MBD4
R8640 T10410 T10408 boundBy MBP,MeCP
R662 T386 T387 boundBy other genes,interferon regulatory factor 4
R8627 T10400 T10401 boundBy these tested DNMT,DNMT1
R8628 T10400 T10402 boundBy these tested DNMT,DNMT3A
R8629 T10400 T10403 boundBy these tested DNMT,DNMT3B
R8630 T10404 T10405 boundBy MBPs,MBD1
R8631 T10404 T10406 boundBy MBPs,MBD2
R8632 T10404 T10407 boundBy MBPs,MBD4
R8633 T10404 T10408 boundBy MBPs,MeCP
R10351 T12442 T12443 boundBy these elements,NFκB elements
R10352 T12444 T12445 boundBy this IRF,IFN consensus sequence binding protein

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T420 0-15 NN denotes Down-regulation
T421 16-18 IN denotes of
T422 19-29 NN denotes interferon
T423 30-40 JJ denotes regulatory
T424 41-47 NN denotes factor
T425 48-49 CD denotes 4
T426 50-54 NN denotes gene
T427 55-65 NN denotes expression
T428 66-68 IN denotes in
T429 69-77 JJ denotes leukemic
T430 78-83 NNS denotes cells
T431 84-87 JJ denotes due
T432 88-90 TO denotes to
T433 91-107 NN denotes hypermethylation
T434 108-110 IN denotes of
T435 111-114 NNP denotes CpG
T436 115-121 NNS denotes motifs
T437 122-124 IN denotes in
T438 125-128 DT denotes the
T439 129-137 NN denotes promoter
T440 138-144 NN denotes region
T441 156-164 IN denotes Although
T442 165-168 DT denotes the
T443 169-176 JJ denotes bcr-abl
T444 177-190 NN denotes translocation
T445 191-194 VBZ denotes has
T446 195-199 VBN denotes been
T447 200-205 VBN denotes shown
T448 206-208 TO denotes to
T449 209-211 VB denotes be
T450 212-215 DT denotes the
T451 216-225 JJ denotes causative
T452 226-233 JJ denotes genetic
T453 234-244 NN denotes aberration
T454 245-247 IN denotes in
T455 248-255 JJ denotes chronic
T456 256-263 JJ denotes myeloid
T457 264-272 NN denotes leukemia
T458 273-274 -LRB- denotes (
T459 274-277 NNP denotes CML
T460 277-278 -RRB- denotes )
T461 278-279 , denotes ,
T462 280-285 EX denotes there
T463 286-288 VBZ denotes is
T464 289-297 VBG denotes mounting
T465 298-306 NN denotes evidence
T466 307-311 IN denotes that
T467 312-315 DT denotes the
T468 316-328 NN denotes deregulation
T469 329-331 IN denotes of
T470 332-337 JJ denotes other
T471 338-343 NNS denotes genes
T472 343-344 , denotes ,
T473 345-349 JJ denotes such
T474 350-352 IN denotes as
T475 353-356 DT denotes the
T476 357-370 NN denotes transcription
T477 371-377 NN denotes factor
T478 378-388 NN denotes interferon
T479 389-399 JJ denotes regulatory
T480 400-406 NN denotes factor
T481 407-408 CD denotes 4
T482 409-410 -LRB- denotes (
T483 410-415 NN denotes IRF-4
T484 415-416 -RRB- denotes )
T485 416-417 , denotes ,
T486 418-420 VBZ denotes is
T487 421-425 RB denotes also
T488 426-436 VBN denotes implicated
T489 437-439 IN denotes in
T490 440-443 DT denotes the
T491 444-456 NN denotes pathogenesis
T492 457-459 IN denotes of
T493 460-463 NNP denotes CML
T494 463-464 . denotes .
T495 465-473 NN denotes Promoter
T496 474-485 NN denotes methylation
T497 486-488 IN denotes of
T498 489-492 NNP denotes CpG
T499 493-499 NN denotes target
T500 500-505 NNS denotes sites
T501 506-508 CC denotes or
T502 509-515 JJ denotes direct
T503 516-536 NNS denotes deletions/insertions
T504 537-539 IN denotes of
T505 540-545 NNS denotes genes
T506 546-549 VBP denotes are
T507 550-560 NNS denotes mechanisms
T508 561-563 IN denotes of
T509 564-565 DT denotes a
T510 566-576 JJ denotes reversible
T511 577-579 CC denotes or
T512 580-589 JJ denotes permanent
T513 590-599 NN denotes silencing
T514 600-602 IN denotes of
T515 603-607 NN denotes gene
T516 608-618 NN denotes expression
T517 618-619 , denotes ,
T518 620-632 RB denotes respectively
T519 632-633 . denotes .
T520 634-643 RB denotes Therefore
T521 643-644 , denotes ,
T522 645-647 PRP denotes we
T523 648-660 VBD denotes investigated
T524 661-668 IN denotes whether
T525 669-674 NN denotes IRF-4
T526 675-683 NN denotes promoter
T527 684-695 NN denotes methylation
T528 696-698 CC denotes or
T529 699-707 NN denotes mutation
T530 708-711 MD denotes may
T531 712-714 VB denotes be
T532 715-723 VBN denotes involved
T533 724-726 IN denotes in
T534 727-730 DT denotes the
T535 731-741 NN denotes regulation
T536 742-744 IN denotes of
T537 745-750 NN denotes IRF-4
T538 751-761 NN denotes expression
T539 762-764 IN denotes in
T540 765-773 NN denotes leukemia
T541 774-779 NNS denotes cells
T542 779-780 . denotes .
T543 781-788 IN denotes Whereas
T544 789-797 NN denotes promoter
T545 798-807 NNS denotes mutations
T546 808-810 CC denotes or
T547 811-821 JJ denotes structural
T548 822-836 NNS denotes rearrangements
T549 837-842 MD denotes could
T550 843-845 VB denotes be
T551 846-854 VBN denotes excluded
T552 855-857 IN denotes as
T553 858-859 DT denotes a
T554 860-865 NN denotes cause
T555 866-868 IN denotes of
T556 869-876 JJ denotes altered
T557 877-882 NN denotes IRF-4
T558 883-893 NN denotes expression
T559 894-896 IN denotes in
T560 897-910 JJ denotes hematopoietic
T561 911-916 NNS denotes cells
T562 916-917 , denotes ,
T563 918-921 DT denotes the
T564 922-927 NNP denotes IRF-4
T565 928-936 NN denotes promoter
T566 937-948 NN denotes methylation
T567 949-955 NN denotes status
T568 956-959 VBD denotes was
T569 960-965 VBN denotes found
T570 966-968 TO denotes to
T571 969-982 RB denotes significantly
T572 983-992 VB denotes influence
T573 993-998 JJ denotes IRF-4
T574 999-1012 NN denotes transcription
T575 1012-1013 . denotes .
T576 1014-1019 RB denotes First
T577 1019-1020 , denotes ,
T578 1021-1030 NN denotes treatment
T579 1031-1033 IN denotes of
T580 1034-1048 JJ denotes IRF-4-negative
T581 1049-1057 NN denotes lymphoid
T582 1057-1058 , denotes ,
T583 1059-1066 JJ denotes myeloid
T584 1067-1070 CC denotes and
T585 1071-1080 JJ denotes monocytic
T586 1081-1085 NN denotes cell
T587 1086-1091 NNS denotes lines
T588 1092-1096 IN denotes with
T589 1097-1100 DT denotes the
T590 1101-1122 NN denotes methylation-inhibitor
T591 1123-1144 JJ denotes 5-aza-2-deoxycytidine
T592 1145-1153 VBD denotes resulted
T593 1154-1156 IN denotes in
T594 1157-1158 DT denotes a
T595 1159-1163 NN denotes time
T596 1163-1164 : denotes -
T597 1165-1168 CC denotes and
T598 1169-1192 JJ denotes concentration-dependent
T599 1193-1201 NN denotes increase
T600 1202-1204 IN denotes of
T601 1205-1210 NNP denotes IRF-4
T602 1211-1215 NNP denotes mRNA
T603 1216-1219 CC denotes and
T604 1220-1227 NN denotes protein
T605 1228-1234 NNS denotes levels
T606 1234-1235 . denotes .
T607 1236-1242 NNP denotes Second
T608 1242-1243 , denotes ,
T609 1244-1249 VBG denotes using
T610 1250-1251 DT denotes a
T611 1252-1273 JJ denotes restriction-PCR-assay
T612 1274-1277 CC denotes and
T613 1278-1298 JJ denotes bisulfite-sequencing
T614 1299-1301 PRP denotes we
T615 1302-1312 VBD denotes identified
T616 1313-1325 RB denotes specifically
T617 1326-1336 VBN denotes methylated
T618 1337-1340 NNP denotes CpG
T619 1341-1346 NNS denotes sites
T620 1347-1349 IN denotes in
T621 1350-1364 JJ denotes IRF-4-negative
T622 1365-1368 CC denotes but
T623 1369-1372 RB denotes not
T624 1373-1375 IN denotes in
T625 1376-1390 JJ denotes IRF-4-positive
T626 1391-1396 NNS denotes cells
T627 1396-1397 . denotes .
T628 1398-1403 NNP denotes Third
T629 1403-1404 , denotes ,
T630 1405-1407 PRP denotes we
T631 1408-1415 RB denotes clearly
T632 1416-1426 VBD denotes determined
T633 1427-1435 NN denotes promoter
T634 1436-1447 NN denotes methylation
T635 1448-1450 IN denotes as
T636 1451-1452 DT denotes a
T637 1453-1462 NN denotes mechanism
T638 1463-1466 IN denotes for
T639 1467-1472 NNP denotes IRF-4
T640 1473-1488 NN denotes down-regulation
T641 1489-1492 IN denotes via
T642 1493-1501 NN denotes reporter
T643 1502-1506 NN denotes gene
T644 1507-1513 NNS denotes assays
T645 1513-1514 , denotes ,
T646 1515-1518 CC denotes but
T647 1519-1522 VBD denotes did
T648 1523-1526 RB denotes not
T649 1527-1533 VB denotes detect
T650 1534-1536 DT denotes an
T651 1537-1548 NN denotes association
T652 1549-1551 IN denotes of
T653 1552-1565 JJ denotes methylational
T654 1566-1572 NN denotes status
T655 1573-1576 CC denotes and
T656 1577-1581 NNP denotes mRNA
T657 1582-1592 NN denotes expression
T658 1593-1595 IN denotes of
T659 1596-1599 NNP denotes DNA
T660 1600-1618 NNS denotes methyltransferases
T661 1619-1621 CC denotes or
T662 1622-1640 JJ denotes methyl-CpG-binding
T663 1641-1649 NNS denotes proteins
T664 1649-1650 . denotes .
T665 1651-1659 RB denotes Together
T666 1659-1660 , denotes ,
T667 1661-1666 DT denotes these
T668 1667-1671 NNS denotes data
T669 1672-1679 VBP denotes suggest
T670 1680-1683 NNP denotes CpG
T671 1684-1697 JJ denotes site-specific
T672 1698-1703 NN denotes IRF-4
T673 1704-1712 NN denotes promoter
T674 1713-1724 NN denotes methylation
T675 1725-1727 IN denotes as
T676 1728-1729 DT denotes a
T677 1730-1738 JJ denotes putative
T678 1739-1748 NN denotes mechanism
T679 1749-1751 IN denotes of
T680 1752-1766 JJ denotes down-regulated
T681 1767-1772 NN denotes IRF-4
T682 1773-1783 NN denotes expression
T683 1784-1786 IN denotes in
T684 1787-1795 NN denotes leukemia
T685 1795-1796 . denotes .
T1725 1811-1818 JJ denotes Chronic
T1726 1819-1826 JJ denotes myeloid
T1727 1827-1835 NN denotes leukemia
T1728 1836-1837 -LRB- denotes (
T1729 1837-1840 NNP denotes CML
T1730 1840-1841 -RRB- denotes )
T1731 1842-1844 VBZ denotes is
T1732 1845-1846 DT denotes a
T1733 1847-1853 JJ denotes clonal
T1734 1854-1872 JJ denotes myeloproliferative
T1735 1873-1881 NN denotes disorder
T1736 1882-1886 IN denotes with
T1737 1887-1888 DT denotes a
T1738 1889-1896 JJ denotes typical
T1739 1897-1902 CD denotes three
T1740 1903-1909 VBD denotes phased
T1741 1910-1916 NN denotes course
T1742 1917-1918 -LRB- denotes (
T1743 1918-1925 NN denotes chronic
T1744 1925-1926 , denotes ,
T1745 1927-1938 VBD denotes accelerated
T1746 1939-1942 CC denotes and
T1747 1943-1950 JJ denotes blastic
T1748 1951-1956 NN denotes phase
T1749 1956-1957 -RRB- denotes )
T1750 1958-1968 VBG denotes reflecting
T1751 1969-1972 DT denotes the
T1752 1973-1977 NN denotes loss
T1753 1978-1980 IN denotes of
T1754 1981-1996 NN denotes differentiation
T1755 1997-2000 CC denotes and
T1756 2001-2010 JJ denotes malignant
T1757 2011-2019 NN denotes progress
T1758 2020-2025 WDT denotes which
T1759 2026-2036 RB denotes inevitably
T1760 2037-2042 VBZ denotes leads
T1761 2043-2045 TO denotes to
T1762 2046-2051 NN denotes death
T1763 2052-2057 IN denotes after
T1764 2058-2061 DT denotes the
T1765 2062-2069 JJ denotes blastic
T1766 2070-2075 NN denotes phase
T1767 2076-2077 -LRB- denotes (
T1768 2077-2080 CD denotes 1,2
T1769 2080-2081 -RRB- denotes )
T1770 2081-2082 . denotes .
T1771 2083-2086 DT denotes The
T1772 2087-2095 NN denotes hallmark
T1773 2096-2103 JJ denotes genetic
T1774 2104-2114 NN denotes aberration
T1775 2115-2117 IN denotes of
T1776 2118-2121 NNP denotes CML
T1777 2122-2124 VBZ denotes is
T1778 2125-2126 DT denotes a
T1779 2127-2137 JJ denotes reciprocal
T1780 2138-2149 JJ denotes chromosomal
T1781 2150-2163 NN denotes translocation
T1782 2164-2165 NN denotes t
T1783 2165-2166 -LRB- denotes (
T1784 2166-2167 CD denotes 9
T1785 2167-2168 : denotes ;
T1786 2168-2170 CD denotes 22
T1787 2170-2171 -RRB- denotes )
T1788 2172-2179 VBG denotes leading
T1789 2180-2182 TO denotes to
T1790 2183-2193 NN denotes expression
T1791 2194-2196 IN denotes of
T1792 2197-2198 DT denotes a
T1793 2199-2206 JJ denotes bcr-abl
T1794 2207-2213 NN denotes fusion
T1795 2214-2218 NN denotes gene
T1796 2218-2219 , denotes ,
T1797 2220-2222 DT denotes an
T1798 2223-2231 JJ denotes aberrant
T1799 2232-2241 VBN denotes activated
T1800 2242-2250 NN denotes tyrosine
T1801 2251-2257 NN denotes kinase
T1802 2258-2259 -LRB- denotes (
T1803 2259-2260 LS denotes 2
T1804 2260-2261 -RRB- denotes )
T1805 2261-2262 . denotes .
T1806 2263-2272 NNP denotes Treatment
T1807 2273-2277 IN denotes with
T1808 2278-2288 NN denotes interferon
T1809 2289-2290 NN denotes α
T1810 2291-2292 -LRB- denotes (
T1811 2292-2297 NNP denotes IFN-α
T1812 2297-2298 -RRB- denotes )
T1813 2299-2307 NNS denotes prolongs
T1814 2308-2316 NN denotes survival
T1815 2317-2319 IN denotes of
T1816 2320-2323 NNP denotes CML
T1817 2324-2332 NNS denotes patients
T1818 2333-2336 CC denotes and
T1819 2337-2339 VBZ denotes is
T1820 2340-2350 VBN denotes associated
T1821 2351-2355 IN denotes with
T1822 2356-2357 DT denotes a
T1823 2358-2366 JJ denotes complete
T1824 2367-2378 JJ denotes cytogenetic
T1825 2379-2387 NN denotes response
T1826 2388-2390 IN denotes in
T1827 2391-2392 CD denotes 5
T1828 2393-2395 CD denotes 33
T1829 2395-2396 NN denotes %
T1830 2397-2399 IN denotes of
T1831 2400-2403 NNP denotes CML
T1832 2404-2412 NNS denotes patients
T1833 2413-2414 -LRB- denotes (
T1834 2414-2417 CD denotes 1,2
T1835 2417-2418 -RRB- denotes )
T1836 2418-2419 . denotes .
T1837 2420-2428 RB denotes Recently
T1838 2428-2429 , denotes ,
T1839 2430-2432 PRP denotes we
T1840 2433-2442 VBD denotes described
T1841 2443-2445 DT denotes an
T1842 2446-2454 VBN denotes impaired
T1843 2455-2465 NN denotes expression
T1844 2466-2468 IN denotes of
T1845 2469-2472 DT denotes the
T1846 2473-2483 NN denotes interferon
T1847 2484-2494 JJ denotes regulatory
T1848 2495-2501 NN denotes factor
T1849 2502-2503 CD denotes 4
T1850 2504-2505 -LRB- denotes (
T1851 2505-2510 NN denotes IRF-4
T1852 2510-2511 -RRB- denotes )
T1853 2512-2514 IN denotes in
T1854 2515-2518 NNP denotes CML
T1855 2518-2519 , denotes ,
T1856 2520-2531 VBG denotes correlating
T1857 2532-2536 IN denotes with
T1858 2537-2541 JJ denotes poor
T1859 2542-2550 NN denotes response
T1860 2551-2553 TO denotes to
T1861 2554-2559 JJ denotes IFN-α
T1862 2560-2569 NN denotes treatment
T1863 2570-2571 -LRB- denotes (
T1864 2571-2572 LS denotes 3
T1865 2572-2573 -RRB- denotes )
T1866 2573-2574 . denotes .
T1867 2575-2578 DT denotes The
T1868 2579-2584 NN denotes cause
T1869 2585-2587 IN denotes of
T1870 2588-2591 DT denotes the
T1871 2592-2601 NN denotes silencing
T1872 2602-2604 IN denotes of
T1873 2605-2610 JJ denotes IRF-4
T1874 2611-2616 NN denotes level
T1875 2617-2625 VBD denotes remained
T1876 2626-2633 JJ denotes unclear
T1877 2633-2634 . denotes .
T1878 2635-2645 NNP denotes Interferon
T1879 2646-2656 JJ denotes regulatory
T1880 2657-2664 NNS denotes factors
T1881 2665-2666 -LRB- denotes (
T1882 2666-2670 NNS denotes IRFs
T1883 2670-2671 -RRB- denotes )
T1884 2672-2675 VBP denotes are
T1885 2676-2677 DT denotes a
T1886 2678-2684 NN denotes family
T1887 2685-2687 IN denotes of
T1888 2688-2703 JJ denotes transcriptional
T1889 2704-2714 NNS denotes regulators
T1890 2715-2722 VBN denotes defined
T1891 2723-2725 IN denotes by
T1892 2726-2727 DT denotes a
T1893 2728-2742 JJ denotes characteristic
T1894 2743-2751 NN denotes homology
T1895 2752-2754 IN denotes in
T1896 2755-2760 PRP$ denotes their
T1897 2761-2772 JJ denotes DNA-binding
T1898 2773-2779 NN denotes domain
T1899 2779-2780 . denotes .
T1900 2781-2785 PRP denotes They
T1901 2786-2790 VBP denotes play
T1902 2791-2793 DT denotes an
T1903 2794-2803 JJ denotes important
T1904 2804-2808 NN denotes role
T1905 2809-2811 IN denotes in
T1906 2812-2815 DT denotes the
T1907 2816-2826 NN denotes regulation
T1908 2827-2829 IN denotes of
T1909 2830-2837 JJ denotes various
T1910 2838-2843 NNS denotes genes
T1911 2844-2845 -LRB- denotes (
T1912 2845-2849 JJ denotes such
T1913 2850-2852 IN denotes as
T1914 2853-2857 NNS denotes IFNs
T1915 2857-2858 , denotes ,
T1916 2859-2871 NNS denotes interleukins
T1917 2871-2872 , denotes ,
T1918 2873-2876 NNP denotes MHC
T1919 2877-2882 NN denotes class
T1920 2883-2887 NNP denotes I/II
T1921 2887-2888 -RRB- denotes )
T1922 2888-2889 , denotes ,
T1923 2890-2899 NN denotes apoptosis
T1924 2900-2903 CC denotes and
T1925 2904-2930 NN denotes differentiation/maturation
T1926 2931-2932 -LRB- denotes (
T1927 2932-2933 CD denotes 4
T1928 2934-2935 CD denotes 6
T1929 2935-2936 -RRB- denotes )
T1930 2936-2937 . denotes .
T1931 2938-2943 NN denotes IRF-4
T1932 2944-2945 -LRB- denotes (
T1933 2945-2959 JJ denotes ICSAT/Pip/MUM1
T1934 2959-2960 NN denotes /
T1935 2960-2965 NNP denotes LSIRF
T1936 2965-2966 -RRB- denotes )
T1937 2967-2969 VBZ denotes is
T1938 2970-2973 CD denotes one
T1939 2974-2980 NN denotes member
T1940 2981-2985 IN denotes with
T1941 2986-2990 RB denotes very
T1942 2991-3001 VBN denotes restricted
T1943 3002-3012 NN denotes expression
T1944 3013-3020 NN denotes pattern
T1945 3020-3021 : denotes :
T1946 3022-3035 NNP denotes Predominately
T1947 3036-3037 NNP denotes B
T1948 3037-3038 : denotes -
T1949 3039-3042 CC denotes and
T1950 3043-3052 VBN denotes activated
T1951 3053-3066 NNS denotes T-lymphocytes
T1952 3067-3070 VBP denotes are
T1953 3071-3076 JJ denotes IRF-4
T1954 3077-3085 JJ denotes positive
T1955 3086-3087 -LRB- denotes (
T1956 3087-3088 CD denotes 7
T1957 3089-3091 CD denotes 11
T1958 3091-3092 -RRB- denotes )
T1959 3092-3093 . denotes .
T1960 3094-3096 IN denotes In
T1961 3097-3105 NN denotes contrast
T1962 3106-3108 TO denotes to
T1963 3109-3114 JJ denotes other
T1964 3115-3119 NNS denotes IRFs
T1965 3119-3120 , denotes ,
T1966 3121-3131 NN denotes expression
T1967 3132-3134 IN denotes of
T1968 3135-3140 NN denotes IRF-4
T1969 3141-3144 MD denotes can
T1970 3144-3147 RB denotes not
T1971 3148-3150 VB denotes be
T1972 3151-3158 VBN denotes induced
T1973 3159-3161 IN denotes by
T1974 3162-3166 NNS denotes IFNs
T1975 3166-3167 , denotes ,
T1976 3168-3171 CC denotes but
T1977 3172-3174 IN denotes by
T1978 3175-3182 NN denotes antigen
T1979 3183-3194 NN denotes stimulation
T1980 3194-3195 , denotes ,
T1981 3196-3208 NN denotes crosslinking
T1982 3209-3211 IN denotes of
T1983 3212-3213 SYM denotes T
T1984 3213-3214 : denotes -
T1985 3215-3217 CC denotes or
T1986 3218-3224 NNP denotes B-cell
T1987 3225-3234 NNS denotes receptors
T1988 3235-3237 CC denotes or
T1989 3238-3263 NN denotes phorbol-myristate-acetate
T1990 3264-3265 -LRB- denotes (
T1991 3265-3270 CD denotes 10,11
T1992 3270-3271 -RRB- denotes )
T1993 3271-3272 . denotes .
T1994 3273-3283 JJ denotes Consistent
T1995 3284-3288 IN denotes with
T1996 3289-3292 DT denotes the
T1997 3293-3304 NN denotes restriction
T1998 3305-3307 IN denotes of
T1999 3308-3318 NN denotes expression
T2000 3319-3321 TO denotes to
T2001 3322-3337 JJ denotes immunocompetent
T2002 3338-3343 NNS denotes cells
T2003 3343-3344 , denotes ,
T2004 3345-3349 NNS denotes mice
T2005 3350-3354 IN denotes with
T2006 3355-3363 NN denotes deletion
T2007 3364-3366 IN denotes of
T2008 3367-3372 NN denotes IRF-4
T2009 3373-3379 VBD denotes failed
T2010 3380-3382 TO denotes to
T2011 3383-3390 VB denotes develop
T2012 3391-3397 JJ denotes mature
T2013 3398-3401 CC denotes and
T2014 3402-3414 RB denotes functionally
T2015 3415-3421 JJ denotes active
T2016 3422-3423 NNP denotes B
T2017 3423-3424 : denotes -
T2018 3425-3428 CC denotes and
T2019 3429-3442 NNS denotes T-lymphocytes
T2020 3443-3444 -LRB- denotes (
T2021 3444-3446 CD denotes 12
T2022 3446-3447 -RRB- denotes )
T2023 3447-3448 , denotes ,
T2024 3449-3452 CC denotes and
T2025 3453-3456 DT denotes the
T2026 3457-3465 VBN denotes impaired
T2027 3466-3476 NN denotes expression
T2028 3477-3479 IN denotes of
T2029 3480-3485 NN denotes IRF-4
T2030 3486-3488 IN denotes in
T2031 3489-3492 NNP denotes CML
T2032 3493-3496 VBD denotes was
T2033 3497-3510 RB denotes predominately
T2034 3511-3516 VBN denotes found
T2035 3517-3519 IN denotes in
T2036 3520-3527 NNS denotes T-cells
T2037 3528-3529 -LRB- denotes (
T2038 3529-3530 CD denotes 3
T2039 3530-3531 -RRB- denotes )
T2040 3531-3532 . denotes .
T2041 3533-3538 DT denotes These
T2042 3539-3543 NNS denotes data
T2043 3544-3551 VBP denotes suggest
T2044 3552-3553 DT denotes a
T2045 3554-3561 JJ denotes crucial
T2046 3562-3566 NN denotes role
T2047 3567-3570 IN denotes for
T2048 3571-3576 NN denotes IRF-4
T2049 3577-3579 IN denotes in
T2050 3580-3583 DT denotes the
T2051 3584-3592 NN denotes function
T2052 3593-3595 IN denotes of
T2053 3596-3602 JJ denotes immune
T2054 3603-3608 NNS denotes cells
T2055 3608-3609 . denotes .
T2056 3610-3621 NNP denotes Methylation
T2057 3622-3624 IN denotes of
T2058 3625-3637 NN denotes dinucleotide
T2059 3638-3656 JJ denotes cytosine-guanosine
T2060 3657-3663 NNS denotes motifs
T2061 3664-3665 -LRB- denotes (
T2062 3665-3668 NNP denotes CpG
T2063 3668-3669 -RRB- denotes )
T2064 3669-3670 , denotes ,
T2065 3671-3681 RB denotes especially
T2066 3682-3684 IN denotes in
T2067 3685-3688 NNP denotes CpG
T2068 3689-3696 NNS denotes islands
T2069 3697-3704 VBN denotes located
T2070 3705-3707 IN denotes in
T2071 3708-3716 NN denotes promoter
T2072 3717-3724 NNS denotes regions
T2073 3724-3725 , denotes ,
T2074 3726-3728 VBZ denotes is
T2075 3729-3732 CD denotes one
T2076 3733-3735 IN denotes of
T2077 3736-3739 DT denotes the
T2078 3740-3750 NNS denotes mechanisms
T2079 3751-3753 IN denotes of
T2080 3754-3758 NN denotes gene
T2081 3759-3769 NN denotes regulation
T2082 3770-3772 IN denotes in
T2083 3773-3780 NNS denotes mammals
T2084 3781-3784 CC denotes and
T2085 3785-3786 DT denotes a
T2086 3787-3793 JJ denotes common
T2087 3794-3799 NN denotes event
T2088 3800-3802 IN denotes of
T2089 3803-3807 NN denotes gene
T2090 3808-3817 VBG denotes silencing
T2091 3818-3820 IN denotes in
T2092 3821-3826 JJ denotes human
T2093 3827-3837 NNS denotes neoplasias
T2094 3838-3839 -LRB- denotes (
T2095 3839-3844 CD denotes 13,14
T2096 3844-3845 -RRB- denotes )
T2097 3845-3846 . denotes .
T2098 3847-3849 IN denotes As
T2099 3850-3857 VBN denotes opposed
T2100 3858-3860 TO denotes to
T2101 3861-3867 JJ denotes normal
T2102 3868-3873 NNS denotes cells
T2103 3873-3874 , denotes ,
T2104 3875-3891 NN denotes hypermethylation
T2105 3892-3894 IN denotes of
T2106 3895-3898 NNP denotes CpG
T2107 3899-3906 NNS denotes islands
T2108 3907-3909 VBZ denotes is
T2109 3910-3911 DT denotes a
T2110 3912-3922 RB denotes frequently
T2111 3923-3931 JJ denotes observed
T2112 3932-3942 NN denotes phenomenon
T2113 3943-3945 IN denotes in
T2114 3946-3951 DT denotes every
T2115 3952-3958 NN denotes cancer
T2116 3959-3963 NN denotes type
T2117 3963-3964 . denotes .
T2118 3965-3967 NNP denotes De
T2119 3968-3972 NNP denotes novo
T2120 3973-3976 NNP denotes DNA
T2121 3977-3988 NN denotes methylation
T2122 3989-3991 IN denotes of
T2123 3992-3997 NNS denotes genes
T2124 3998-4002 JJ denotes such
T2125 4003-4005 IN denotes as
T2126 4006-4010 NN denotes cell
T2127 4011-4016 NN denotes cycle
T2128 4016-4017 , denotes ,
T2129 4018-4021 NNP denotes DNA
T2130 4022-4028 NN denotes repair
T2131 4028-4029 , denotes ,
T2132 4030-4039 NN denotes apoptosis
T2133 4040-4043 CC denotes and
T2134 4044-4049 NN denotes tumor
T2135 4050-4060 NN denotes suppressor
T2136 4061-4066 NNS denotes genes
T2137 4067-4069 VBZ denotes is
T2138 4070-4079 RB denotes therefore
T2139 4080-4087 VBN denotes thought
T2140 4088-4090 TO denotes to
T2141 4091-4093 VB denotes be
T2142 4094-4102 VBN denotes involved
T2143 4103-4105 IN denotes in
T2144 4106-4119 NN denotes tumorigenesis
T2145 4120-4121 -LRB- denotes (
T2146 4121-4123 CD denotes 15
T2147 4124-4126 CD denotes 17
T2148 4126-4127 -RRB- denotes )
T2149 4127-4128 . denotes .
T2150 4129-4137 NNS denotes Examples
T2151 4138-4141 IN denotes for
T2152 4142-4146 JJ denotes such
T2153 4147-4156 JJ denotes aberrated
T2154 4157-4162 NNS denotes genes
T2155 4163-4166 VBP denotes are
T2156 4167-4171 NNP denotes MGMT
T2157 4171-4172 , denotes ,
T2158 4173-4177 NNP denotes DAPK
T2159 4177-4178 , denotes ,
T2160 4179-4185 NNP denotes p14ARF
T2161 4185-4186 , denotes ,
T2162 4187-4195 NNP denotes p15INK4b
T2163 4195-4196 , denotes ,
T2164 4197-4205 NNP denotes p16INK4a
T2165 4205-4206 , denotes ,
T2166 4207-4212 NNP denotes BRCA1
T2167 4212-4213 , denotes ,
T2168 4214-4219 NNP denotes CDH13
T2169 4220-4223 CC denotes and
T2170 4224-4230 NNP denotes APAF-1
T2171 4231-4232 -LRB- denotes (
T2172 4232-4234 CD denotes 17
T2173 4235-4237 CD denotes 19
T2174 4237-4238 -RRB- denotes )
T2175 4238-4239 . denotes .
T2176 4240-4242 IN denotes In
T2177 4243-4246 NNP denotes CML
T2178 4246-4247 , denotes ,
T2179 4248-4259 NN denotes methylation
T2180 4260-4262 VBZ denotes is
T2181 4263-4268 VBN denotes known
T2182 4269-4271 TO denotes to
T2183 4272-4280 VB denotes regulate
T2184 4281-4291 NN denotes expression
T2185 4292-4294 IN denotes of
T2186 4295-4298 DT denotes the
T2187 4299-4304 NN denotes c-abl
T2188 4304-4305 , denotes ,
T2189 4306-4309 DT denotes the
T2190 4310-4313 NN denotes bcr
T2191 4314-4318 NN denotes gene
T2192 4319-4322 CC denotes and
T2193 4323-4329 NNS denotes others
T2194 4330-4331 -LRB- denotes (
T2195 4331-4333 CD denotes 20
T2196 4334-4336 CD denotes 23
T2197 4336-4337 -RRB- denotes )
T2198 4337-4338 , denotes ,
T2199 4339-4342 CC denotes and
T2200 4343-4346 DT denotes the
T2201 4347-4353 NN denotes extent
T2202 4354-4356 IN denotes of
T2203 4357-4368 NN denotes methylation
T2204 4369-4371 IN denotes in
T2205 4372-4375 DT denotes the
T2206 4376-4381 JJ denotes c-abl
T2207 4382-4390 NN denotes promoter
T2208 4391-4394 VBZ denotes has
T2209 4395-4399 VBN denotes been
T2210 4400-4405 VBN denotes shown
T2211 4406-4408 TO denotes to
T2212 4409-4411 VB denotes be
T2213 4412-4422 VBN denotes associated
T2214 4423-4427 IN denotes with
T2215 4428-4436 JJ denotes advanced
T2216 4437-4444 NN denotes disease
T2217 4445-4446 -LRB- denotes (
T2218 4446-4448 CD denotes 24
T2219 4448-4449 -RRB- denotes )
T2220 4449-4450 . denotes .
T2221 4451-4467 NNP denotes Hypermethylation
T2222 4468-4471 JJ denotes due
T2223 4472-4474 TO denotes to
T2224 4475-4489 NN denotes overexpression
T2225 4490-4492 IN denotes of
T2226 4493-4496 NNP denotes DNA
T2227 4497-4515 NNS denotes methyltransferases
T2228 4516-4517 -LRB- denotes (
T2229 4517-4522 NNS denotes DNMTs
T2230 4522-4523 -RRB- denotes )
T2231 4524-4531 VBZ denotes remains
T2232 4532-4535 CD denotes one
T2233 4536-4544 JJ denotes possible
T2234 4545-4556 NN denotes explanation
T2235 4557-4560 IN denotes for
T2236 4561-4563 FW denotes de
T2237 4564-4568 FW denotes novo
T2238 4569-4580 NN denotes methylation
T2239 4581-4583 IN denotes in
T2240 4584-4597 NN denotes tumorigenesis
T2241 4597-4598 . denotes .
T2242 4599-4607 RB denotes Recently
T2243 4607-4608 , denotes ,
T2244 4609-4614 NNS denotes DNMTs
T2245 4615-4619 VBP denotes have
T2246 4620-4624 VBN denotes been
T2247 4625-4630 VBN denotes shown
T2248 4631-4633 TO denotes to
T2249 4634-4636 VB denotes be
T2250 4637-4649 JJ denotes up-regulated
T2251 4650-4652 IN denotes in
T2252 4653-4666 JJ denotes hematopoietic
T2253 4667-4679 NNS denotes malignancies
T2254 4680-4681 -LRB- denotes (
T2255 4681-4683 CD denotes 25
T2256 4683-4684 -RRB- denotes )
T2257 4684-4685 . denotes .
T2258 4686-4704 VBG denotes Methyl-CpG-binding
T2259 4705-4713 NNS denotes proteins
T2260 4714-4715 -LRB- denotes (
T2261 4715-4719 NNS denotes MBPs
T2262 4719-4720 -RRB- denotes )
T2263 4721-4724 VBP denotes are
T2264 4725-4732 VBN denotes thought
T2265 4733-4735 TO denotes to
T2266 4736-4743 VB denotes inhibit
T2267 4744-4747 DT denotes the
T2268 4748-4755 JJ denotes binding
T2269 4756-4758 IN denotes of
T2270 4759-4774 JJ denotes transcriptional
T2271 4775-4782 NNS denotes factors
T2272 4783-4785 TO denotes to
T2273 4786-4789 DT denotes the
T2274 4790-4798 NN denotes promoter
T2275 4799-4802 CC denotes and
T2276 4803-4806 VBP denotes are
T2277 4807-4816 RB denotes therefore
T2278 4817-4826 VBN denotes discussed
T2279 4827-4829 IN denotes as
T2280 4830-4833 CD denotes one
T2281 4834-4843 NN denotes mechanism
T2282 4844-4846 IN denotes of
T2283 4847-4860 NN denotes transcription
T2284 4861-4871 NN denotes inhibition
T2285 4872-4874 IN denotes by
T2286 4875-4891 NN denotes hypermethylation
T2287 4892-4893 -LRB- denotes (
T2288 4893-4895 CD denotes 26
T2289 4895-4896 -RRB- denotes )
T2290 4896-4897 . denotes .
T2291 4898-4900 IN denotes In
T2292 4901-4905 DT denotes this
T2293 4906-4910 NN denotes work
T2294 4910-4911 , denotes ,
T2295 4912-4914 PRP denotes we
T2296 4915-4922 VBD denotes studied
T2297 4923-4933 NNS denotes mechanisms
T2298 4934-4936 IN denotes of
T2299 4937-4942 NN denotes IRF-4
T2300 4943-4947 NN denotes gene
T2301 4948-4958 NN denotes expression
T2302 4959-4968 VBG denotes silencing
T2303 4969-4971 IN denotes in
T2304 4972-4980 JJ denotes leukemic
T2305 4981-4986 NNS denotes cells
T2306 4986-4987 . denotes .
T2307 4988-4990 PRP denotes We
T2308 4991-4999 VBD denotes analyzed
T2309 5000-5003 DT denotes the
T2310 5004-5009 NN denotes IRF-4
T2311 5010-5018 NN denotes promoter
T2312 5019-5025 NN denotes region
T2313 5026-5029 IN denotes for
T2314 5030-5037 JJ denotes genetic
T2315 5038-5049 NNS denotes aberrations
T2316 5050-5053 CC denotes and
T2317 5054-5067 JJ denotes methylational
T2318 5068-5074 NN denotes status
T2319 5075-5077 IN denotes in
T2320 5078-5092 JJ denotes IRF-4-positive
T2321 5093-5096 CC denotes and
T2322 5097-5098 : denotes -
T2323 5098-5106 JJ denotes negative
T2324 5107-5120 JJ denotes hematopoietic
T2325 5121-5126 NNS denotes cells
T2326 5126-5127 . denotes .
T2774 5152-5156 NN denotes Cell
T2775 5157-5162 NNS denotes lines
T2776 5163-5168 NNP denotes K-562
T2777 5168-5169 , denotes ,
T2778 5170-5176 NNP denotes Jurkat
T2779 5177-5180 CC denotes and
T2780 5181-5186 NNP denotes U-937
T2781 5187-5191 VBD denotes were
T2782 5192-5200 VBN denotes obtained
T2783 5201-5205 IN denotes from
T2784 5206-5209 DT denotes the
T2785 5210-5214 NNP denotes ATCC
T2786 5215-5216 -LRB- denotes (
T2787 5216-5224 NNP denotes American
T2788 5225-5229 NNP denotes Type
T2789 5230-5237 NNP denotes Culture
T2790 5238-5248 NNP denotes Collection
T2791 5248-5249 , denotes ,
T2792 5250-5259 NNP denotes Rockville
T2793 5259-5260 , denotes ,
T2794 5261-5264 NNP denotes USA
T2795 5264-5265 -RRB- denotes )
T2796 5266-5269 CC denotes and
T2797 5270-5274 NNP denotes EM-2
T2798 5274-5275 , denotes ,
T2799 5276-5283 NNP denotes LAMA-84
T2800 5283-5284 , denotes ,
T2801 5285-5291 NNP denotes CML-T1
T2802 5291-5292 , denotes ,
T2803 5293-5299 NNP denotes BV-173
T2804 5299-5300 , denotes ,
T2805 5301-5305 NNP denotes SD-1
T2806 5306-5309 CC denotes and
T2807 5310-5319 NNP denotes RPMI-8226
T2808 5320-5324 IN denotes from
T2809 5325-5328 DT denotes the
T2810 5329-5333 NNP denotes DSMZ
T2811 5334-5335 -LRB- denotes (
T2812 5335-5343 NNP denotes Deutsche
T2813 5344-5352 NNP denotes Sammlung
T2814 5353-5356 NNP denotes von
T2815 5357-5372 NNP denotes Mikroorganismen
T2816 5373-5376 NN denotes und
T2817 5377-5389 NNP denotes Zellkulturen
T2818 5390-5394 NNP denotes GmbH
T2819 5394-5395 , denotes ,
T2820 5396-5408 NNP denotes Braunschweig
T2821 5408-5409 , denotes ,
T2822 5410-5417 NNP denotes Germany
T2823 5417-5418 -RRB- denotes )
T2824 5418-5419 . denotes .
T2825 5420-5423 DT denotes All
T2826 5424-5428 NN denotes cell
T2827 5429-5434 NNS denotes lines
T2828 5434-5435 , denotes ,
T2829 5436-5442 IN denotes except
T2830 5443-5449 NNP denotes BV-173
T2831 5449-5450 , denotes ,
T2832 5451-5455 NNP denotes SD-1
T2833 5456-5459 CC denotes and
T2834 5460-5469 NNP denotes RPMI-8226
T2835 5469-5470 , denotes ,
T2836 5471-5475 VBD denotes were
T2837 5476-5490 JJ denotes IRF-4-negative
T2838 5490-5491 . denotes .
T2949 5493-5497 NNP denotes Cell
T2950 5498-5505 NN denotes culture
T2951 5506-5509 CC denotes and
T2952 5510-5521 NN denotes stimulation
T2953 5522-5525 DT denotes All
T2954 5526-5530 NN denotes cell
T2955 5531-5536 NNS denotes lines
T2956 5537-5541 VBD denotes were
T2957 5542-5552 VBN denotes maintained
T2958 5553-5555 IN denotes at
T2959 5556-5557 CD denotes 5
T2960 5557-5558 NN denotes %
T2961 5559-5562 CD denotes CO2
T2962 5563-5565 IN denotes in
T2963 5566-5570 NNP denotes RPMI
T2964 5571-5575 CD denotes 1640
T2965 5576-5582 NN denotes medium
T2966 5583-5587 IN denotes with
T2967 5588-5589 CD denotes 1
T2968 5589-5590 NN denotes %
T2969 5591-5600 NN denotes glutamine
T2970 5601-5602 -LRB- denotes (
T2971 5602-5611 NNP denotes Gibco/BRL
T2972 5612-5622 NNP denotes Eggenstein
T2973 5622-5623 , denotes ,
T2974 5624-5631 NNP denotes Germany
T2975 5631-5632 -RRB- denotes )
T2976 5633-5645 VBN denotes supplemented
T2977 5646-5650 IN denotes with
T2978 5651-5653 CD denotes 10
T2979 5653-5654 NN denotes %
T2980 5655-5660 JJ denotes fetal
T2981 5661-5665 NN denotes calf
T2982 5666-5671 NN denotes serum
T2983 5672-5673 -LRB- denotes (
T2984 5673-5682 NNP denotes Gibco/BRL
T2985 5682-5683 -RRB- denotes )
T2986 5683-5684 , denotes ,
T2987 5685-5686 CD denotes 1
T2988 5686-5687 NN denotes %
T2989 5688-5711 NN denotes penicillin/streptomycin
T2990 5712-5713 -LRB- denotes (
T2991 5713-5721 NNP denotes Biochrom
T2992 5721-5722 , denotes ,
T2993 5723-5729 NNP denotes Berlin
T2994 5729-5730 , denotes ,
T2995 5731-5738 NNP denotes Germany
T2996 5738-5739 -RRB- denotes )
T2997 5739-5740 . denotes .
T2998 5741-5745 WRB denotes When
T2999 5746-5755 VBN denotes indicated
T3000 5755-5756 , denotes ,
T3001 5757-5762 NNS denotes cells
T3002 5763-5767 VBD denotes were
T3003 5768-5775 VBN denotes treated
T3004 5776-5780 IN denotes with
T3005 5781-5802 JJ denotes 5-aza-2-deoxycytidine
T3006 5803-5804 -LRB- denotes (
T3007 5804-5809 NNP denotes AzadC
T3008 5809-5810 -RRB- denotes )
T3009 5811-5813 CC denotes or
T3010 5814-5827 JJ denotes 5-azacytidine
T3011 5828-5829 -LRB- denotes (
T3012 5829-5833 NNP denotes AzaC
T3013 5833-5834 -RRB- denotes )
T3014 5835-5836 -LRB- denotes (
T3015 5836-5841 NNP denotes Sigma
T3016 5841-5842 , denotes ,
T3017 5843-5854 NNP denotes Taufkirchen
T3018 5854-5855 , denotes ,
T3019 5856-5863 NNP denotes Germany
T3020 5863-5864 -RRB- denotes )
T3021 5865-5868 IN denotes for
T3022 5869-5878 JJ denotes different
T3023 5879-5883 NN denotes time
T3024 5884-5891 NNS denotes periods
T3025 5891-5892 . denotes .
T3026 5893-5898 VBG denotes Owing
T3027 5899-5901 TO denotes to
T3028 5902-5907 PRP$ denotes their
T3029 5908-5916 NN denotes chemical
T3030 5917-5928 NN denotes instability
T3031 5929-5934 JJ denotes fresh
T3032 5935-5945 NNS denotes substances
T3033 5946-5950 VBD denotes were
T3034 5951-5959 JJ denotes re-added
T3035 5960-5965 DT denotes every
T3036 5966-5968 CD denotes 24
T3037 5969-5971 NN denotes h.
T3192 5973-5983 VBG denotes Sequencing
T3193 5984-5986 IN denotes of
T3194 5987-5990 DT denotes the
T3195 5991-5996 NN denotes IRF-4
T3196 5997-6005 NN denotes promoter
T3197 6006-6009 IN denotes For
T3198 6010-6018 NN denotes analysis
T3199 6019-6021 IN denotes of
T3200 6022-6025 DT denotes the
T3201 6026-6031 NN denotes IRF-4
T3202 6032-6040 NN denotes promoter
T3203 6041-6047 NN denotes region
T3204 6048-6051 IN denotes for
T3205 6052-6061 JJ denotes permanent
T3206 6062-6073 NNS denotes aberrations
T3207 6074-6078 JJ denotes such
T3208 6079-6081 IN denotes as
T3209 6082-6102 NNS denotes insertions/deletions
T3210 6103-6105 CC denotes or
T3211 6106-6114 NN denotes mutation
T3212 6114-6115 , denotes ,
T3213 6116-6118 PRP denotes we
T3214 6119-6132 VBD denotes PCR-amplified
T3215 6133-6136 CD denotes two
T3216 6137-6146 NNS denotes fragments
T3217 6147-6151 IN denotes from
T3218 6152-6159 JJ denotes genomic
T3219 6160-6163 NN denotes DNA
T3220 6163-6164 , denotes ,
T3221 6165-6170 WDT denotes which
T3222 6171-6174 VBD denotes was
T3223 6175-6184 VBN denotes extracted
T3224 6185-6189 IN denotes from
T3225 6190-6198 VBN denotes depicted
T3226 6199-6203 NN denotes cell
T3227 6204-6209 NNS denotes lines
T3228 6210-6214 IN denotes with
T3229 6215-6216 DT denotes a
T3230 6217-6227 JJ denotes commercial
T3231 6228-6231 NN denotes kit
T3232 6232-6233 -LRB- denotes (
T3233 6233-6239 NNP denotes Qiagen
T3234 6239-6240 , denotes ,
T3235 6241-6246 NNP denotes Hilde
T3236 6246-6247 , denotes ,
T3237 6248-6255 NNP denotes Germany
T3238 6255-6256 -RRB- denotes )
T3239 6257-6259 IN denotes as
T3240 6260-6271 VBN denotes recommended
T3241 6271-6272 . denotes .
T3242 6273-6276 DT denotes The
T3243 6277-6284 NNS denotes primers
T3244 6285-6289 VBD denotes were
T3245 6290-6299 JJ denotes 1-forward
T3246 6299-6300 : denotes :
T3247 6301-6302 CD denotes 5
T3248 6302-6303 SYM denotes ′
T3249 6303-6304 : denotes -
T3250 6304-6328 NN denotes TTGAGATGGAGTCTTGCTCTGT-3
T3251 6328-6329 NN denotes ′
T3252 6329-6330 , denotes ,
T3253 6331-6340 JJ denotes 1-reverse
T3254 6340-6341 : denotes :
T3255 6342-6343 CD denotes 5
T3256 6343-6344 SYM denotes ′
T3257 6344-6345 : denotes -
T3258 6345-6370 NN denotes CCAGGACCTCAGGAGGCCAGTCA-3
T3259 6370-6371 NN denotes ′
T3260 6371-6372 : denotes ;
T3261 6373-6382 JJ denotes 2-forward
T3262 6382-6383 : denotes :
T3263 6384-6385 CD denotes 5
T3264 6385-6386 SYM denotes ′
T3265 6386-6387 : denotes -
T3266 6387-6414 NN denotes AGCGGTGAAACTGAGAGTGCGAGGT-3
T3267 6414-6415 NN denotes ′
T3268 6415-6416 , denotes ,
T3269 6417-6426 JJ denotes 2-reverse
T3270 6426-6427 : denotes :
T3271 6428-6429 CD denotes 5
T3272 6429-6430 SYM denotes ′
T3273 6430-6431 : denotes -
T3274 6431-6453 NN denotes GCCACATCGCTGCAGTTTAG-3
T3275 6453-6454 NN denotes ′
T3276 6454-6455 . denotes .
T3277 6456-6459 DT denotes The
T3278 6460-6468 NNS denotes products
T3279 6469-6473 VBD denotes were
T3280 6474-6480 VBN denotes cloned
T3281 6481-6485 IN denotes with
T3282 6486-6489 DT denotes the
T3283 6491-6495 NNP denotes TOPO
T3284 6496-6498 NNP denotes TA
T3285 6499-6506 VBG denotes cloning
T3286 6507-6510 NN denotes kit
T3287 6512-6513 -LRB- denotes (
T3288 6513-6523 NNP denotes Invitrogen
T3289 6523-6524 , denotes ,
T3290 6525-6534 NNP denotes Groningen
T3291 6534-6535 , denotes ,
T3292 6536-6539 DT denotes The
T3293 6540-6551 NNP denotes Netherlands
T3294 6551-6552 -RRB- denotes )
T3295 6552-6553 . denotes .
T3296 6554-6559 IN denotes After
T3297 6560-6569 JJ denotes bacterial
T3298 6570-6583 NN denotes amplification
T3299 6584-6586 IN denotes of
T3300 6587-6590 DT denotes the
T3301 6591-6597 VBN denotes cloned
T3302 6598-6601 NNP denotes PCR
T3303 6602-6611 NNS denotes fragments
T3304 6612-6614 IN denotes by
T3305 6615-6623 JJ denotes standard
T3306 6624-6634 NNS denotes procedures
T3307 6634-6635 , denotes ,
T3308 6636-6638 IN denotes at
T3309 6639-6644 JJS denotes least
T3310 6645-6650 CD denotes three
T3311 6651-6657 NNS denotes clones
T3312 6658-6662 IN denotes from
T3313 6663-6667 DT denotes each
T3314 6668-6674 NN denotes sample
T3315 6675-6679 VBD denotes were
T3316 6680-6689 VBN denotes sequenced
T3317 6690-6694 IN denotes with
T3318 6695-6697 DT denotes an
T3319 6698-6707 VBN denotes automated
T3320 6708-6717 NN denotes sequencer
T3321 6718-6719 -LRB- denotes (
T3322 6719-6722 NNP denotes ABI
T3323 6723-6728 NNP denotes Prism
T3324 6729-6732 CD denotes 377
T3325 6732-6733 , denotes ,
T3326 6734-6741 NNP denotes Applied
T3327 6742-6753 NNPS denotes Bio-systems
T3328 6753-6754 , denotes ,
T3329 6755-6761 NNP denotes Foster
T3330 6762-6766 NNP denotes City
T3331 6766-6767 , denotes ,
T3332 6768-6771 NNP denotes USA
T3333 6771-6772 -RRB- denotes )
T3334 6773-6775 IN denotes as
T3335 6776-6787 VBN denotes recommended
T3336 6788-6790 IN denotes by
T3337 6791-6794 DT denotes the
T3338 6795-6807 NN denotes manufacturer
T3339 6807-6808 . denotes .
T3802 6810-6820 NN denotes Expression
T3803 6821-6829 NN denotes analysis
T3804 6830-6832 TO denotes To
T3805 6833-6840 VB denotes analyze
T3806 6841-6844 DT denotes the
T3807 6845-6850 NN denotes IRF-4
T3808 6851-6866 JJ denotes transcriptional
T3809 6867-6872 NN denotes level
T3810 6872-6873 , denotes ,
T3811 6874-6877 NNP denotes RNA
T3812 6878-6881 VBD denotes was
T3813 6882-6891 VBN denotes extracted
T3814 6892-6896 IN denotes from
T3815 6897-6902 NNS denotes cells
T3816 6903-6908 VBG denotes using
T3817 6909-6912 DT denotes the
T3818 6913-6923 JJ denotes commercial
T3819 6924-6934 NN denotes RNAzol-kit
T3820 6935-6936 -LRB- denotes (
T3821 6936-6942 NNP denotes Paesel
T3822 6942-6943 , denotes ,
T3823 6944-6953 NNP denotes Frankfurt
T3824 6953-6954 , denotes ,
T3825 6955-6962 NNP denotes Germany
T3826 6962-6963 -RRB- denotes )
T3827 6963-6964 . denotes .
T3828 6965-6967 DT denotes An
T3829 6968-6975 NN denotes aliquot
T3830 6976-6978 IN denotes of
T3831 6979-6980 CD denotes 1
T3832 6981-6983 NN denotes μg
T3833 6984-6989 JJ denotes total
T3834 6990-6993 NNP denotes RNA
T3835 6994-6997 VBD denotes was
T3836 6998-7002 VBN denotes used
T3837 7003-7006 IN denotes for
T3838 7007-7011 NNP denotes cDNA
T3839 7012-7021 NN denotes synthesis
T3840 7022-7024 IN denotes as
T3841 7025-7034 VBN denotes described
T3842 7035-7045 RB denotes previously
T3843 7046-7047 -LRB- denotes (
T3844 7047-7049 CD denotes 27
T3845 7049-7050 -RRB- denotes )
T3846 7050-7051 . denotes .
T3847 7052-7055 NNP denotes RNA
T3848 7056-7066 NN denotes expression
T3849 7067-7075 NN denotes analysis
T3850 7076-7079 IN denotes for
T3851 7080-7085 NNP denotes IRF-4
T3852 7086-7089 CC denotes and
T3853 7090-7093 DT denotes the
T3854 7094-7103 NN denotes reference
T3855 7104-7108 NN denotes gene
T3856 7109-7116 NN denotes β-actin
T3857 7117-7120 VBD denotes was
T3858 7121-7128 VBN denotes carried
T3859 7129-7132 RP denotes out
T3860 7133-7135 IN denotes by
T3861 7136-7153 JJ denotes semi-quantitative
T3862 7154-7157 NNP denotes PCR
T3863 7158-7160 IN denotes as
T3864 7161-7170 VBN denotes described
T3865 7171-7181 RB denotes previously
T3866 7182-7183 -LRB- denotes (
T3867 7183-7187 CD denotes 3,27
T3868 7187-7188 -RRB- denotes )
T3869 7188-7189 . denotes .
T3870 7190-7193 NNP denotes PCR
T3871 7194-7202 NNS denotes products
T3872 7203-7207 VBD denotes were
T3873 7208-7216 VBN denotes verified
T3874 7217-7219 IN denotes by
T3875 7220-7229 JJ denotes automated
T3876 7230-7240 NN denotes sequencing
T3877 7240-7241 . denotes .
T3878 7242-7245 NNP denotes PCR
T3879 7246-7253 NNS denotes primers
T3880 7254-7257 CC denotes and
T3881 7258-7268 NNS denotes conditions
T3882 7269-7272 IN denotes for
T3883 7273-7283 NN denotes expression
T3884 7284-7292 NN denotes analysis
T3885 7293-7295 IN denotes of
T3886 7296-7300 NNP denotes DNMT
T3887 7301-7303 CC denotes or
T3888 7304-7307 NNP denotes MBP
T3889 7308-7309 -LRB- denotes (
T3890 7309-7314 NNP denotes DNMT1
T3891 7315-7321 NNP denotes DNMT3A
T3892 7321-7322 , denotes ,
T3893 7323-7329 NNP denotes DNMT3B
T3894 7329-7330 , denotes ,
T3895 7331-7335 NNP denotes MeCP
T3896 7335-7336 , denotes ,
T3897 7337-7341 NNP denotes MBD1
T3898 7341-7342 , denotes ,
T3899 7343-7347 NNP denotes MBD2
T3900 7348-7351 CC denotes and
T3901 7352-7356 NNP denotes MBD4
T3902 7356-7357 -RRB- denotes )
T3903 7358-7362 VBD denotes were
T3904 7363-7372 VBN denotes published
T3905 7373-7382 RB denotes elsewhere
T3906 7383-7384 -LRB- denotes (
T3907 7384-7386 CD denotes 28
T3908 7386-7387 -RRB- denotes )
T3909 7387-7388 . denotes .
T3910 7389-7392 IN denotes For
T3911 7393-7401 NN denotes analysis
T3912 7402-7404 IN denotes of
T3913 7405-7410 NN denotes IRF-4
T3914 7411-7418 NN denotes protein
T3915 7419-7429 NN denotes expression
T3916 7429-7430 , denotes ,
T3917 7431-7432 DT denotes a
T3918 7433-7441 JJ denotes standard
T3919 7442-7456 NN denotes immunoblotting
T3920 7457-7462 NN denotes assay
T3921 7463-7466 VBD denotes was
T3922 7467-7476 VBN denotes performed
T3923 7477-7479 IN denotes as
T3924 7480-7489 VBN denotes described
T3925 7490-7500 RB denotes previously
T3926 7501-7502 -LRB- denotes (
T3927 7502-7504 CD denotes 29
T3928 7504-7505 -RRB- denotes )
T3929 7505-7506 . denotes .
T3930 7507-7514 RB denotes Briefly
T3931 7514-7515 , denotes ,
T3932 7516-7523 NN denotes protein
T3933 7524-7531 NNS denotes lysates
T3934 7532-7536 VBD denotes were
T3935 7537-7546 VBN denotes generated
T3936 7547-7549 IN denotes by
T3937 7550-7560 VBG denotes incubating
T3938 7561-7562 CD denotes 1
T3939 7563-7564 CD denotes ×
T3940 7565-7568 CD denotes 106
T3941 7569-7574 NNS denotes cells
T3942 7575-7577 IN denotes in
T3943 7578-7581 CD denotes 100
T3944 7582-7584 NN denotes µl
T3945 7585-7589 NNP denotes RIPA
T3946 7590-7596 NN denotes buffer
T3947 7597-7598 -LRB- denotes (
T3948 7598-7599 CD denotes 1
T3949 7599-7600 NN denotes %
T3950 7601-7606 NN denotes NP-40
T3951 7606-7607 , denotes ,
T3952 7608-7611 CD denotes 0.5
T3953 7611-7612 NN denotes %
T3954 7613-7632 NN denotes sodiumdesoxycholate
T3955 7632-7633 , denotes ,
T3956 7634-7637 CD denotes 0.1
T3957 7637-7638 NN denotes %
T3958 7639-7642 NNP denotes SDS
T3959 7642-7643 , denotes ,
T3960 7644-7647 CD denotes 100
T3961 7648-7650 NN denotes µg
T3962 7650-7651 NN denotes /
T3963 7651-7653 NN denotes ml
T3964 7654-7674 NN denotes phenylmethylsulfonyl
T3965 7675-7683 NN denotes fluoride
T3966 7683-7684 , denotes ,
T3967 7685-7687 CD denotes 10
T3968 7688-7690 NN denotes µl
T3969 7690-7691 NN denotes /
T3970 7691-7693 NN denotes ml
T3971 7694-7717 NN denotes protease-inhibitory-mix
T3972 7717-7718 , denotes ,
T3973 7719-7720 CD denotes 1
T3974 7721-7725 NN denotes µmol
T3975 7725-7726 CD denotes /
T3976 7726-7728 NN denotes ml
T3977 7729-7748 NN denotes sodiumorthovanadate
T3978 7749-7751 IN denotes in
T3979 7752-7770 JJ denotes phosphate-buffered
T3980 7771-7777 NN denotes saline
T3981 7777-7778 -RRB- denotes )
T3982 7779-7782 IN denotes for
T3983 7783-7785 CD denotes 30
T3984 7786-7789 NN denotes min
T3985 7790-7792 IN denotes on
T3986 7793-7796 NN denotes ice
T3987 7796-7797 . denotes .
T3988 7798-7803 IN denotes After
T3989 7804-7818 NN denotes centrifugation
T3990 7818-7819 , denotes ,
T3991 7820-7827 NN denotes protein
T3992 7828-7841 NN denotes concentration
T3993 7842-7844 IN denotes of
T3994 7845-7848 DT denotes the
T3995 7849-7860 NN denotes supernatant
T3996 7861-7864 VBD denotes was
T3997 7865-7875 VBN denotes determined
T3998 7876-7878 IN denotes by
T3999 7879-7889 JJ denotes BCA-method
T4000 7890-7891 -LRB- denotes (
T4001 7891-7897 NNP denotes Pierce
T4002 7897-7898 , denotes ,
T4003 7899-7907 NNP denotes Rockford
T4004 7907-7908 , denotes ,
T4005 7909-7911 NNP denotes IL
T4006 7911-7912 -RRB- denotes )
T4007 7913-7915 IN denotes as
T4008 7916-7927 VBN denotes recommended
T4009 7927-7928 . denotes .
T4010 7929-7936 NNP denotes Protein
T4011 7937-7944 VBZ denotes lysates
T4012 7945-7946 -LRB- denotes (
T4013 7946-7948 CD denotes 70
T4014 7949-7952 CD denotes 100
T4015 7953-7955 NN denotes µg
T4016 7955-7956 -RRB- denotes )
T4017 7957-7961 VBD denotes were
T4018 7962-7977 VBN denotes electrophoresed
T4019 7978-7980 IN denotes on
T4020 7981-7995 NN denotes polyacrylamide
T4021 7996-8000 NNS denotes gels
T4022 8001-8004 CC denotes and
T4023 8005-8016 VBN denotes transferred
T4024 8017-8019 TO denotes to
T4025 8020-8021 DT denotes a
T4026 8022-8035 NN denotes PVDF-membrane
T4027 8036-8037 -LRB- denotes (
T4028 8037-8046 NNP denotes Immobilon
T4029 8047-8048 NNP denotes P
T4030 8048-8049 , denotes ,
T4031 8050-8054 CD denotes 0.45
T4032 8055-8057 NN denotes µm
T4033 8057-8058 : denotes ;
T4034 8059-8068 NNP denotes Millipore
T4035 8068-8069 , denotes ,
T4036 8070-8078 NNP denotes Eschborn
T4037 8078-8079 , denotes ,
T4038 8080-8087 NNP denotes Germany
T4039 8087-8088 -RRB- denotes )
T4040 8088-8089 . denotes .
T4041 8090-8099 NNS denotes Membranes
T4042 8100-8104 VBD denotes were
T4043 8105-8112 VBN denotes blocked
T4044 8113-8117 IN denotes with
T4045 8118-8121 CD denotes 2.5
T4046 8121-8122 NN denotes %
T4047 8123-8131 VBG denotes blocking
T4048 8132-8139 NN denotes reagent
T4049 8140-8141 -LRB- denotes (
T4050 8141-8151 NNP denotes Boehringer
T4051 8152-8160 NNP denotes Mannheim
T4052 8160-8161 , denotes ,
T4053 8162-8169 NNP denotes Germany
T4054 8169-8170 -RRB- denotes )
T4055 8171-8173 IN denotes in
T4056 8174-8178 NNP denotes TBST
T4057 8179-8185 NN denotes buffer
T4058 8186-8187 -LRB- denotes (
T4059 8187-8191 CD denotes 4.44
T4060 8192-8195 NN denotes g/l
T4061 8196-8200 NNP denotes Tris
T4062 8201-8204 NNP denotes HCL
T4063 8204-8205 , denotes ,
T4064 8206-8210 CD denotes 2.65
T4065 8211-8214 NN denotes g/l
T4066 8215-8221 NNP denotes TrisOH
T4067 8221-8222 , denotes ,
T4068 8223-8227 CD denotes 8.07
T4069 8228-8231 NN denotes g/l
T4070 8232-8236 NNP denotes NaCl
T4071 8236-8237 , denotes ,
T4072 8238-8241 CD denotes 0.2
T4073 8242-8245 NN denotes g/l
T4074 8246-8249 NNP denotes KCl
T4075 8250-8253 CC denotes and
T4076 8254-8257 CD denotes 500
T4077 8258-8260 NN denotes µl
T4078 8260-8261 NN denotes /
T4079 8261-8262 NN denotes l
T4080 8263-8271 NN denotes Tween-20
T4081 8272-8274 IN denotes in
T4082 8275-8278 CD denotes H2O
T4083 8278-8279 -RRB- denotes )
T4084 8280-8283 CC denotes and
T4085 8284-8296 RB denotes subsequently
T4086 8297-8306 VBN denotes incubated
T4087 8307-8311 IN denotes with
T4088 8312-8319 JJ denotes primary
T4089 8320-8328 NN denotes antibody
T4090 8329-8331 IN denotes as
T4091 8332-8341 VBN denotes indicated
T4092 8342-8345 CC denotes and
T4093 8346-8357 JJ denotes horseradish
T4094 8358-8379 JJ denotes peroxidase-conjugated
T4095 8380-8389 JJ denotes secondary
T4096 8390-8398 NN denotes antibody
T4097 8398-8399 , denotes ,
T4098 8400-8410 JJ denotes anti-mouse
T4099 8411-8413 CC denotes or
T4100 8414-8423 JJ denotes anti-goat
T4101 8424-8427 NNP denotes IgG
T4102 8428-8429 -LRB- denotes (
T4103 8429-8433 NNP denotes DAKO
T4104 8433-8434 , denotes ,
T4105 8435-8442 NNP denotes Hamburg
T4106 8442-8443 , denotes ,
T4107 8444-8451 NNP denotes Germany
T4108 8451-8452 -RRB- denotes )
T4109 8452-8453 , denotes ,
T4110 8454-8466 RB denotes respectively
T4111 8466-8467 . denotes .
T4112 8468-8471 DT denotes The
T4113 8472-8481 NNS denotes membranes
T4114 8482-8486 VBD denotes were
T4115 8487-8491 RB denotes then
T4116 8492-8501 VBN denotes developed
T4117 8502-8506 IN denotes with
T4118 8507-8509 DT denotes an
T4119 8510-8513 NNP denotes ECL
T4120 8514-8523 NN denotes detection
T4121 8524-8527 NN denotes kit
T4122 8528-8529 -LRB- denotes (
T4123 8529-8537 NNP denotes Amersham
T4124 8538-8547 NNP denotes Pharmacia
T4125 8548-8555 NNP denotes Biotech
T4126 8555-8556 , denotes ,
T4127 8557-8565 NNP denotes Freiburg
T4128 8565-8566 , denotes ,
T4129 8567-8574 NNP denotes Germany
T4130 8574-8575 -RRB- denotes )
T4131 8575-8576 . denotes .
T4132 8577-8580 DT denotes The
T4133 8581-8588 JJ denotes primary
T4134 8589-8599 NNS denotes antibodies
T4135 8600-8604 VBD denotes were
T4136 8605-8609 JJ denotes goat
T4137 8610-8620 JJ denotes anti-IRF-4
T4138 8620-8621 NN denotes /
T4139 8621-8626 NNP denotes ICSAT
T4140 8627-8628 -LRB- denotes (
T4141 8628-8632 NNP denotes M-17
T4142 8632-8633 -RRB- denotes )
T4143 8634-8635 -LRB- denotes (
T4144 8635-8640 NNP denotes Santa
T4145 8641-8645 NNP denotes Cruz
T4146 8646-8659 NNP denotes Biotechnology
T4147 8659-8660 , denotes ,
T4148 8661-8666 NNP denotes Santa
T4149 8667-8671 NNP denotes Cruz
T4150 8671-8672 , denotes ,
T4151 8673-8675 NNP denotes CA
T4152 8675-8676 -RRB- denotes )
T4153 8677-8680 CC denotes and
T4154 8681-8686 NN denotes mouse
T4155 8687-8699 NN denotes anti-β-actin
T4156 8700-8701 -LRB- denotes (
T4157 8701-8706 NN denotes AC-74
T4158 8706-8707 -RRB- denotes )
T4159 8708-8709 -LRB- denotes (
T4160 8709-8714 NNP denotes Sigma
T4161 8714-8715 -RRB- denotes )
T4162 8715-8716 . denotes .
T4626 8718-8738 JJ denotes Methylation-specific
T4627 8739-8760 JJ denotes restriction-PCR-assay
T4628 8761-8764 NN denotes DNA
T4629 8765-8768 VBD denotes was
T4630 8769-8778 VBN denotes extracted
T4631 8779-8783 IN denotes with
T4632 8784-8785 DT denotes a
T4633 8786-8796 JJ denotes commercial
T4634 8797-8800 NN denotes kit
T4635 8801-8802 -LRB- denotes (
T4636 8802-8808 NNP denotes Qiagen
T4637 8808-8809 -RRB- denotes )
T4638 8810-8812 IN denotes as
T4639 8813-8824 VBN denotes recommended
T4640 8824-8825 . denotes .
T4641 8826-8831 IN denotes Since
T4642 8832-8835 DT denotes the
T4643 8836-8847 NN denotes restriction
T4644 8848-8855 NN denotes ability
T4645 8856-8858 IN denotes of
T4646 8859-8866 JJ denotes several
T4647 8867-8880 NNS denotes endonucleases
T4648 8881-8883 VBZ denotes is
T4649 8884-8893 VBN denotes inhibited
T4650 8894-8896 IN denotes by
T4651 8897-8908 NN denotes methylation
T4652 8909-8911 IN denotes of
T4653 8912-8917 PRP$ denotes their
T4654 8918-8924 NN denotes target
T4655 8925-8933 NN denotes sequence
T4656 8933-8934 , denotes ,
T4657 8935-8937 PRP denotes we
T4658 8938-8942 VBD denotes used
T4659 8943-8964 JJ denotes methylation-sensitive
T4660 8965-8972 NNS denotes enzymes
T4661 8973-8978 NNP denotes HpaII
T4662 8979-8982 CC denotes and
T4663 8983-9000 NNP denotes HaeII-isochizomer
T4664 9001-9009 NNP denotes Bsp143II
T4665 9010-9013 CC denotes and
T4666 9014-9022 NNP denotes Bsh1236I
T4667 9023-9024 -LRB- denotes (
T4668 9024-9027 NNP denotes MBI
T4669 9028-9037 NNP denotes Fermentas
T4670 9037-9038 , denotes ,
T4671 9039-9041 NNP denotes St
T4672 9042-9050 NNP denotes Leon-Rot
T4673 9050-9051 , denotes ,
T4674 9052-9059 NNP denotes Germany
T4675 9059-9060 -RRB- denotes )
T4676 9061-9062 -LRB- denotes (
T4677 9062-9067 CD denotes 20,24
T4678 9067-9068 -RRB- denotes )
T4679 9068-9069 . denotes .
T4680 9070-9072 IN denotes As
T4681 9073-9080 NN denotes control
T4682 9081-9084 DT denotes the
T4683 9085-9106 JJ denotes methylation-resistant
T4684 9107-9113 NN denotes enzyme
T4685 9114-9118 NNP denotes MspI
T4686 9119-9122 CC denotes and
T4687 9123-9125 DT denotes an
T4688 9126-9132 NN denotes enzyme
T4689 9133-9137 IN denotes with
T4690 9138-9140 DT denotes no
T4691 9141-9152 NN denotes recognition
T4692 9153-9157 NN denotes site
T4693 9158-9160 IN denotes in
T4694 9161-9164 DT denotes the
T4695 9165-9171 NN denotes target
T4696 9172-9180 NN denotes promoter
T4697 9180-9181 , denotes ,
T4698 9182-9187 NNP denotes EcoRI
T4699 9187-9188 , denotes ,
T4700 9189-9193 VBD denotes were
T4701 9194-9198 VBN denotes used
T4702 9198-9199 . denotes .
T4703 9200-9203 NNP denotes DNA
T4704 9204-9205 -LRB- denotes (
T4705 9205-9208 CD denotes 0.8
T4706 9209-9211 NN denotes µg
T4707 9211-9212 -RRB- denotes )
T4708 9213-9216 VBD denotes was
T4709 9217-9225 VBN denotes digested
T4710 9226-9228 IN denotes by
T4711 9229-9231 CD denotes 40
T4712 9232-9233 NNP denotes U
T4713 9234-9237 DT denotes the
T4714 9238-9248 JJ denotes respective
T4715 9249-9255 NN denotes enzyme
T4716 9256-9259 IN denotes for
T4717 9260-9261 CD denotes 6
T4718 9262-9263 NN denotes h
T4719 9264-9267 CC denotes and
T4720 9267-9268 , denotes ,
T4721 9269-9271 TO denotes to
T4722 9272-9278 VB denotes ensure
T4723 9279-9287 JJ denotes complete
T4724 9288-9296 NN denotes cleavage
T4725 9296-9297 , denotes ,
T4726 9298-9308 JJ denotes additional
T4727 9309-9311 CD denotes 20
T4728 9312-9313 NNP denotes U
T4729 9314-9317 IN denotes for
T4730 9318-9320 CD denotes 16
T4731 9321-9323 NN denotes h.
T4732 9324-9334 RB denotes Thereafter
T4733 9335-9338 CD denotes 100
T4734 9339-9341 NN denotes ng
T4735 9342-9344 IN denotes of
T4736 9345-9353 VBN denotes digested
T4737 9354-9357 NN denotes DNA
T4738 9358-9361 VBD denotes was
T4739 9362-9366 VBN denotes used
T4740 9367-9369 TO denotes to
T4741 9370-9371 DT denotes a
T4742 9372-9375 NNP denotes PCR
T4743 9376-9389 NN denotes amplification
T4744 9390-9392 IN denotes of
T4745 9393-9396 CD denotes two
T4746 9397-9406 NNS denotes fragments
T4747 9407-9408 -LRB- denotes (
T4748 9408-9410 CD denotes F1
T4749 9411-9414 CC denotes and
T4750 9415-9417 CD denotes F2
T4751 9417-9418 -RRB- denotes )
T4752 9419-9427 VBG denotes spanning
T4753 9428-9432 NN denotes part
T4754 9433-9435 IN denotes of
T4755 9436-9439 DT denotes the
T4756 9440-9445 NN denotes IRF-4
T4757 9446-9454 NN denotes promoter
T4758 9455-9456 -LRB- denotes (
T4759 9456-9458 CD denotes 30
T4760 9458-9459 -RRB- denotes )
T4761 9460-9461 -LRB- denotes (
T4762 9461-9468 NNP denotes GenBank
T4763 9469-9475 NNP denotes U52683
T4764 9475-9476 : denotes ;
T4765 9477-9480 VB denotes see
T4766 9481-9487 NN denotes Figure
T4767 9488-9490 NN denotes 3A
T4768 9490-9491 -RRB- denotes )
T4769 9491-9492 . denotes .
T4770 9493-9496 DT denotes The
T4771 9497-9506 NNS denotes sequences
T4772 9507-9509 IN denotes of
T4773 9510-9513 DT denotes the
T4774 9514-9521 NNS denotes primers
T4775 9522-9526 VBD denotes were
T4776 9527-9537 JJ denotes F1-forward
T4777 9537-9538 : denotes :
T4778 9539-9540 CD denotes 5
T4779 9540-9541 SYM denotes ′
T4780 9541-9542 : denotes -
T4781 9542-9566 NN denotes TTGAGATGGAGTCTTGCTCTGT-3
T4782 9566-9567 NN denotes ′
T4783 9567-9568 , denotes ,
T4784 9569-9579 NN denotes F1-reverse
T4785 9579-9580 : denotes :
T4786 9581-9608 JJ denotes ATCACTTCCAGACTTCAGTTCACCT-3
T4787 9608-9609 NN denotes ′
T4788 9610-9611 -LRB- denotes (
T4789 9611-9614 CD denotes 341
T4790 9615-9617 NN denotes bp
T4791 9617-9618 -RRB- denotes )
T4792 9618-9619 : denotes ;
T4793 9620-9630 NNP denotes F2-forward
T4794 9630-9631 : denotes :
T4795 9632-9633 CD denotes 5
T4796 9633-9634 SYM denotes ′
T4797 9634-9635 : denotes -
T4798 9635-9662 NN denotes AAGGTGAACTGAAGTCTGGAAGTGA-3
T4799 9662-9663 NN denotes ′
T4800 9663-9664 , denotes ,
T4801 9665-9675 NN denotes F2-reverse
T4802 9675-9676 : denotes :
T4803 9677-9678 CD denotes 5
T4804 9678-9679 SYM denotes ′
T4805 9679-9680 : denotes -
T4806 9680-9705 NN denotes CCAGGACCTCAGGAGGCCAGTCA-3
T4807 9705-9706 NN denotes ′
T4808 9707-9708 -LRB- denotes (
T4809 9708-9711 CD denotes 474
T4810 9712-9714 NN denotes bp
T4811 9714-9715 -RRB- denotes )
T4812 9715-9716 . denotes .
T4813 9717-9720 DT denotes The
T4814 9721-9724 NNP denotes PCR
T4815 9725-9735 NNS denotes conditions
T4816 9736-9740 VBD denotes were
T4817 9741-9750 VBN denotes described
T4818 9751-9760 RB denotes elsewhere
T4819 9761-9762 -LRB- denotes (
T4820 9762-9763 LS denotes 3
T4821 9763-9764 -RRB- denotes )
T4822 9764-9765 . denotes .
T4823 9766-9769 NNP denotes PCR
T4824 9770-9773 VBD denotes was
T4825 9774-9783 VBN denotes performed
T4826 9784-9788 IN denotes with
T4827 9789-9791 DT denotes an
T4828 9792-9801 NN denotes annealing
T4829 9802-9813 NN denotes temperature
T4830 9814-9816 IN denotes of
T4831 9817-9819 CD denotes 62
T4832 9819-9820 CD denotes °
T4833 9820-9821 NNP denotes C
T4834 9822-9825 CC denotes and
T4835 9826-9828 CD denotes 35
T4836 9829-9835 NNS denotes cycles
T4837 9835-9836 . denotes .
T4838 9837-9841 WRB denotes When
T4839 9842-9845 NNP denotes DNA
T4840 9846-9849 VBD denotes was
T4841 9850-9860 VBN denotes methylated
T4842 9861-9863 IN denotes at
T4843 9864-9872 JJ denotes specific
T4844 9873-9878 NNS denotes sites
T4845 9878-9879 , denotes ,
T4846 9880-9883 DT denotes the
T4847 9884-9893 JJ denotes sensitive
T4848 9894-9901 NNS denotes enzymes
T4849 9902-9906 VBD denotes were
T4850 9907-9910 RB denotes not
T4851 9911-9915 JJ denotes able
T4852 9916-9918 TO denotes to
T4853 9919-9925 VB denotes digest
T4854 9926-9929 DT denotes the
T4855 9930-9933 NN denotes DNA
T4856 9934-9937 CC denotes and
T4857 9938-9951 NN denotes amplification
T4858 9952-9956 VBD denotes took
T4859 9957-9962 NN denotes place
T4860 9962-9963 : denotes ;
T4861 9964-9966 IN denotes in
T4862 9967-9971 NN denotes case
T4863 9972-9974 IN denotes of
T4864 9975-9977 DT denotes no
T4865 9978-9989 NN denotes methylation
T4866 9989-9990 , denotes ,
T4867 9991-9994 NNP denotes DNA
T4868 9995-9998 VBD denotes was
T4869 9999-10007 VBN denotes digested
T4870 10008-10011 CC denotes and
T4871 10012-10014 DT denotes no
T4872 10015-10022 NN denotes product
T4873 10023-10026 VBD denotes was
T4874 10027-10036 VBN denotes generated
T4875 10036-10037 . denotes .
T4876 10038-10041 DT denotes The
T4877 10042-10045 NNP denotes PCR
T4878 10046-10054 NNS denotes products
T4879 10055-10059 VBD denotes were
T4880 10060-10075 VBN denotes electrophoresed
T4881 10076-10078 IN denotes on
T4882 10079-10080 DT denotes a
T4883 10081-10082 CD denotes 3
T4884 10082-10083 NN denotes %
T4885 10084-10091 JJ denotes agarose
T4886 10092-10095 NN denotes gel
T4887 10095-10096 , denotes ,
T4888 10097-10101 VBD denotes were
T4889 10102-10109 VBN denotes stained
T4890 10110-10114 IN denotes with
T4891 10115-10123 NN denotes ethidium
T4892 10124-10131 NN denotes bromide
T4893 10132-10135 CC denotes and
T4894 10136-10148 VBD denotes photographed
T4895 10148-10149 . denotes .
T4896 10150-10153 NNP denotes PCR
T4897 10154-10162 NNS denotes products
T4898 10163-10167 VBD denotes were
T4899 10168-10176 VBN denotes verified
T4900 10177-10179 IN denotes by
T4901 10180-10189 JJ denotes automated
T4902 10190-10200 NN denotes sequencing
T4903 10200-10201 . denotes .
T5272 10203-10212 NNP denotes Bisulfite
T5273 10213-10222 NN denotes treatment
T5274 10223-10226 NN denotes DNA
T5275 10227-10230 VBD denotes was
T5276 10231-10240 VBN denotes extracted
T5277 10241-10243 IN denotes as
T5278 10244-10253 VBN denotes described
T5279 10254-10259 IN denotes above
T5280 10259-10260 . denotes .
T5281 10261-10270 NNP denotes Bisulfite
T5282 10271-10280 NN denotes treatment
T5283 10281-10283 IN denotes of
T5284 10284-10287 NNP denotes DNA
T5285 10287-10288 , denotes ,
T5286 10289-10296 VBG denotes leading
T5287 10297-10299 TO denotes to
T5288 10300-10310 NN denotes conversion
T5289 10311-10313 IN denotes of
T5290 10314-10326 JJ denotes unmethylated
T5291 10327-10335 NN denotes cytosine
T5292 10336-10338 TO denotes to
T5293 10339-10345 VB denotes uracil
T5294 10346-10354 NNS denotes residues
T5295 10355-10358 CC denotes and
T5296 10359-10361 DT denotes no
T5297 10362-10368 NN denotes change
T5298 10369-10371 IN denotes of
T5299 10372-10382 JJ denotes methylated
T5300 10383-10391 NN denotes cytosine
T5301 10392-10400 NNS denotes residues
T5302 10400-10401 , denotes ,
T5303 10402-10405 VBD denotes was
T5304 10406-10415 VBN denotes performed
T5305 10416-10418 IN denotes as
T5306 10419-10428 VBN denotes described
T5307 10429-10431 IN denotes as
T5308 10432-10439 VBZ denotes follows
T5309 10439-10440 . denotes .
T5310 10441-10448 RB denotes Briefly
T5311 10448-10449 , denotes ,
T5312 10450-10451 CD denotes 1
T5313 10452-10454 NN denotes µg
T5314 10455-10457 IN denotes of
T5315 10458-10461 NNP denotes DNA
T5316 10462-10465 CC denotes and
T5317 10466-10467 CD denotes 2
T5318 10468-10470 NN denotes µg
T5319 10471-10473 IN denotes of
T5320 10474-10478 NN denotes poly
T5321 10478-10479 -LRB- denotes (
T5322 10479-10481 NN denotes dA
T5323 10482-10484 NN denotes dT
T5324 10484-10485 -RRB- denotes )
T5325 10485-10486 -LRB- denotes (
T5326 10486-10490 NN denotes poly
T5327 10490-10491 -LRB- denotes (
T5328 10491-10493 NN denotes dA
T5329 10494-10496 NN denotes dT
T5330 10496-10497 -RRB- denotes )
T5331 10498-10508 NNS denotes copolymers
T5332 10509-10510 -LRB- denotes (
T5333 10510-10518 NNP denotes Amersham
T5334 10519-10528 NNP denotes Pharmacia
T5335 10529-10536 NNP denotes Biotech
T5336 10536-10537 -RRB- denotes )
T5337 10538-10542 VBD denotes were
T5338 10543-10554 VBN denotes denaturated
T5339 10555-10558 IN denotes for
T5340 10559-10561 CD denotes 20
T5341 10562-10565 NN denotes min
T5342 10566-10568 IN denotes at
T5343 10569-10571 CD denotes 42
T5344 10571-10572 CD denotes °
T5345 10572-10573 NNP denotes C
T5346 10574-10576 IN denotes in
T5347 10577-10580 CD denotes 0.3
T5348 10581-10582 NNP denotes M
T5349 10583-10587 NNP denotes NaOH
T5350 10588-10590 IN denotes in
T5351 10591-10592 DT denotes a
T5352 10593-10599 NN denotes volume
T5353 10600-10602 IN denotes of
T5354 10603-10605 CD denotes 50
T5355 10606-10608 NN denotes µl
T5356 10608-10609 . denotes .
T5357 10610-10615 JJ denotes Fresh
T5358 10616-10625 NNS denotes solutions
T5359 10626-10628 IN denotes of
T5360 10629-10631 CD denotes 30
T5361 10632-10634 NN denotes µl
T5362 10635-10637 IN denotes of
T5363 10638-10640 CD denotes 10
T5364 10641-10643 NN denotes mM
T5365 10644-10655 NN denotes hydrochinon
T5366 10656-10657 -LRB- denotes (
T5367 10657-10662 NNP denotes Sigma
T5368 10662-10663 -RRB- denotes )
T5369 10664-10667 CC denotes and
T5370 10668-10671 CD denotes 530
T5371 10672-10674 NN denotes µl
T5372 10675-10677 IN denotes of
T5373 10678-10679 CD denotes 3
T5374 10680-10681 NNP denotes M
T5375 10682-10688 NN denotes sodium
T5376 10689-10698 NN denotes bisulfite
T5377 10699-10700 -LRB- denotes (
T5378 10700-10702 NNP denotes pH
T5379 10703-10706 CD denotes 5.0
T5380 10706-10707 : denotes ;
T5381 10708-10713 NNP denotes Sigma
T5382 10713-10714 -RRB- denotes )
T5383 10715-10719 VBD denotes were
T5384 10720-10725 VBN denotes added
T5385 10725-10726 , denotes ,
T5386 10727-10730 DT denotes the
T5387 10731-10739 NN denotes solution
T5388 10740-10743 VBD denotes was
T5389 10744-10750 RB denotes gently
T5390 10751-10756 JJ denotes mixed
T5391 10756-10757 , denotes ,
T5392 10758-10767 VBN denotes overlayed
T5393 10768-10772 IN denotes with
T5394 10773-10780 NN denotes mineral
T5395 10781-10784 NN denotes oil
T5396 10785-10788 CC denotes and
T5397 10789-10798 VBN denotes incubated
T5398 10799-10801 IN denotes in
T5399 10802-10805 DT denotes the
T5400 10806-10810 NN denotes dark
T5401 10811-10814 IN denotes for
T5402 10815-10817 CD denotes 12
T5403 10818-10820 CD denotes 13
T5404 10821-10822 NN denotes h
T5405 10823-10825 IN denotes at
T5406 10826-10828 CD denotes 50
T5407 10828-10829 CD denotes °
T5408 10829-10830 NNP denotes C
T5409 10830-10831 . denotes .
T5410 10832-10835 DT denotes The
T5411 10836-10843 JJ denotes aqueous
T5412 10844-10849 NN denotes phase
T5413 10850-10853 VBD denotes was
T5414 10854-10863 VBN denotes recovered
T5415 10864-10869 VBG denotes using
T5416 10870-10873 DT denotes the
T5417 10875-10881 NNP denotes Wizard
T5418 10882-10885 NNP denotes DNA
T5419 10886-10894 JJ denotes clean-up
T5420 10895-10901 NN denotes system
T5421 10903-10904 -LRB- denotes (
T5422 10904-10911 NNP denotes Promega
T5423 10911-10912 , denotes ,
T5424 10913-10921 NNP denotes Mannheim
T5425 10921-10922 , denotes ,
T5426 10923-10930 NNP denotes Germany
T5427 10930-10931 -RRB- denotes )
T5428 10931-10932 . denotes .
T5429 10933-10936 DT denotes The
T5430 10937-10945 JJ denotes purified
T5431 10946-10949 NN denotes DNA
T5432 10950-10953 VBD denotes was
T5433 10954-10966 RB denotes subsequently
T5434 10967-10972 VBN denotes mixed
T5435 10973-10977 IN denotes with
T5436 10978-10979 CD denotes 1
T5437 10980-10981 NNP denotes M
T5438 10982-10986 NNP denotes NaOH
T5439 10987-10989 TO denotes to
T5440 10990-10991 DT denotes a
T5441 10992-10997 JJ denotes final
T5442 10998-11011 NN denotes concentration
T5443 11012-11014 IN denotes of
T5444 11015-11018 CD denotes 0.3
T5445 11019-11020 NNP denotes M
T5446 11021-11024 CC denotes and
T5447 11025-11034 VBN denotes incubated
T5448 11035-11038 IN denotes for
T5449 11039-11041 CD denotes 20
T5450 11042-11045 NN denotes min
T5451 11046-11048 IN denotes at
T5452 11049-11051 CD denotes 37
T5453 11051-11052 CD denotes °
T5454 11052-11053 NNP denotes C
T5455 11054-11056 TO denotes to
T5456 11057-11063 VB denotes ensure
T5457 11064-11072 JJ denotes complete
T5458 11073-11088 NN denotes desulfonisation
T5459 11088-11089 . denotes .
T5460 11090-11093 NNP denotes DNA
T5461 11094-11097 VBD denotes was
T5462 11098-11105 NN denotes ethanol
T5463 11106-11118 VBN denotes precipitated
T5464 11119-11121 IN denotes in
T5465 11122-11125 DT denotes the
T5466 11126-11134 NN denotes presence
T5467 11135-11137 IN denotes of
T5468 11138-11142 CD denotes 1/10
T5469 11143-11146 NN denotes vol
T5470 11147-11149 IN denotes of
T5471 11150-11151 CD denotes 3
T5472 11152-11153 NNP denotes M
T5473 11154-11160 NN denotes sodium
T5474 11161-11168 NN denotes acetate
T5475 11168-11169 , denotes ,
T5476 11170-11176 VBN denotes washed
T5477 11177-11181 IN denotes with
T5478 11182-11184 CD denotes 70
T5479 11184-11185 NN denotes %
T5480 11186-11193 NN denotes ethanol
T5481 11194-11197 CC denotes and
T5482 11198-11209 VBD denotes resuspended
T5483 11210-11212 IN denotes in
T5484 11213-11215 CD denotes 50
T5485 11216-11218 NN denotes µl
T5486 11219-11222 CD denotes H2O
T5487 11222-11223 . denotes .
T5488 11224-11234 JJ denotes Subsequent
T5489 11235-11238 NNP denotes PCR
T5490 11239-11252 NN denotes amplification
T5491 11253-11255 IN denotes of
T5492 11256-11257 CD denotes 4
T5493 11258-11260 NN denotes µl
T5494 11261-11278 JJ denotes bisulfite-treated
T5495 11279-11282 NN denotes DNA
T5496 11283-11286 VBD denotes was
T5497 11287-11291 VBN denotes used
T5498 11292-11295 IN denotes for
T5499 11296-11303 NN denotes cloning
T5500 11304-11306 IN denotes of
T5501 11307-11310 CD denotes two
T5502 11311-11320 NNS denotes fragments
T5503 11321-11323 IN denotes of
T5504 11324-11327 DT denotes the
T5505 11328-11333 NN denotes IRF-4
T5506 11334-11342 NN denotes promoter
T5507 11343-11344 -LRB- denotes (
T5508 11344-11348 NNP denotes BS-I
T5509 11349-11352 CC denotes and
T5510 11353-11358 NNP denotes BS-II
T5511 11358-11359 -RRB- denotes )
T5512 11360-11364 IN denotes into
T5513 11365-11369 JJ denotes pCR2
T5514 11369-11371 CD denotes .1
T5515 11372-11378 NN denotes vector
T5516 11379-11383 IN denotes with
T5517 11384-11387 DT denotes the
T5518 11389-11393 NNP denotes TOPO
T5519 11394-11396 NNP denotes TA
T5520 11397-11404 VBG denotes cloning
T5521 11405-11408 NN denotes kit
T5522 11410-11411 -LRB- denotes (
T5523 11411-11421 NNP denotes Invitrogen
T5524 11421-11422 -RRB- denotes )
T5525 11423-11424 -LRB- denotes (
T5526 11424-11427 VB denotes see
T5527 11428-11434 NN denotes Figure
T5528 11435-11437 NN denotes 3A
T5529 11437-11438 -RRB- denotes )
T5530 11438-11439 . denotes .
T5531 11440-11443 DT denotes The
T5532 11444-11451 NNS denotes primers
T5533 11452-11456 VBN denotes used
T5534 11457-11460 IN denotes for
T5535 11461-11464 NNP denotes PCR
T5536 11465-11478 NN denotes amplification
T5537 11479-11481 IN denotes of
T5538 11482-11485 DT denotes the
T5539 11486-11490 NNP denotes BS-I
T5540 11491-11494 CC denotes and
T5541 11495-11500 NNP denotes BS-II
T5542 11501-11510 NNS denotes fragments
T5543 11511-11518 VBP denotes contain
T5544 11519-11522 DT denotes the
T5545 11523-11531 JJ denotes putative
T5546 11532-11539 JJ denotes altered
T5547 11540-11548 NN denotes sequence
T5548 11549-11551 IN denotes of
T5549 11552-11555 DT denotes the
T5550 11556-11561 NN denotes sense
T5551 11562-11568 NN denotes strand
T5552 11569-11572 JJ denotes due
T5553 11573-11575 TO denotes to
T5554 11576-11585 VB denotes bisulfite
T5555 11586-11595 NN denotes treatment
T5556 11596-11597 -LRB- denotes (
T5557 11597-11606 JJ denotes converted
T5558 11607-11615 NN denotes cytosine
T5559 11616-11624 NNS denotes residues
T5560 11625-11628 VBP denotes are
T5561 11629-11636 VBN denotes written
T5562 11637-11639 IN denotes in
T5563 11640-11644 JJ denotes bold
T5564 11645-11652 NNS denotes letters
T5565 11652-11653 -RRB- denotes )
T5566 11653-11654 : denotes :
T5567 11655-11667 JJ denotes BS-I-forward
T5568 11668-11669 CD denotes 5
T5569 11669-11670 SYM denotes ′
T5570 11670-11671 : denotes -
T5571 11671-11700 NN denotes TATTTGGATTTTTAGGGAGTTTTTTTT-3
T5572 11700-11701 NN denotes ′
T5573 11701-11702 , denotes ,
T5574 11703-11715 JJ denotes BS-I-reverse
T5575 11716-11717 CD denotes 5
T5576 11717-11718 SYM denotes ′
T5577 11718-11719 : denotes -
T5578 11719-11747 NN denotes ACCCAACTCCCTTAAACTATTAAACT-3
T5579 11747-11748 NN denotes ′
T5580 11749-11750 -LRB- denotes (
T5581 11750-11753 CD denotes 187
T5582 11754-11756 NN denotes bp
T5583 11756-11757 -RRB- denotes )
T5584 11757-11758 : denotes ;
T5585 11759-11772 JJ denotes BS-II-forward
T5586 11773-11774 CD denotes 5
T5587 11774-11775 SYM denotes ′
T5588 11775-11776 : denotes -
T5589 11776-11804 NN denotes AGTTTAATAGTTTAAGGGAGTTGGGT-3
T5590 11804-11805 NN denotes ′
T5591 11805-11806 , denotes ,
T5592 11807-11820 JJ denotes BS-II-reverse
T5593 11821-11822 CD denotes 5
T5594 11822-11823 SYM denotes ′
T5595 11823-11824 : denotes -
T5596 11824-11852 NN denotes CTCACCCTAAACTCAAAACTAAAAAC-3
T5597 11852-11853 NN denotes ′
T5598 11854-11855 -LRB- denotes (
T5599 11855-11858 CD denotes 674
T5600 11859-11861 NN denotes bp
T5601 11861-11862 -RRB- denotes )
T5602 11862-11863 . denotes .
T5603 11864-11869 IN denotes After
T5604 11870-11879 JJ denotes bacterial
T5605 11880-11893 NN denotes amplification
T5606 11894-11896 IN denotes of
T5607 11897-11900 DT denotes the
T5608 11901-11907 VBN denotes cloned
T5609 11908-11911 NNP denotes PCR
T5610 11912-11921 NNS denotes fragments
T5611 11922-11924 IN denotes by
T5612 11925-11933 JJ denotes standard
T5613 11934-11944 NNS denotes procedures
T5614 11944-11945 , denotes ,
T5615 11946-11951 CD denotes eight
T5616 11952-11958 NNS denotes clones
T5617 11959-11963 IN denotes from
T5618 11964-11968 DT denotes each
T5619 11969-11975 NN denotes sample
T5620 11976-11980 VBD denotes were
T5621 11981-11990 VBN denotes sequenced
T5622 11991-11995 IN denotes with
T5623 11996-11998 DT denotes an
T5624 11999-12008 VBN denotes automated
T5625 12009-12018 NN denotes sequencer
T5626 12019-12020 -LRB- denotes (
T5627 12020-12023 NNP denotes ABI
T5628 12024-12029 NNP denotes Prism
T5629 12030-12033 CD denotes 377
T5630 12033-12034 , denotes ,
T5631 12035-12042 NNP denotes Applied
T5632 12043-12053 NNPS denotes Biosystems
T5633 12053-12054 -RRB- denotes )
T5634 12054-12055 . denotes .
T5873 12057-12059 IN denotes In
T5874 12060-12065 NN denotes vitro
T5875 12066-12077 NN denotes methylation
T5876 12078-12081 CC denotes and
T5877 12082-12090 NN denotes reporter
T5878 12091-12095 NN denotes gene
T5879 12096-12102 VBZ denotes assays
T5880 12103-12106 DT denotes The
T5881 12107-12112 JJ denotes IRF-4
T5882 12113-12130 NN denotes promoter-reporter
T5883 12131-12135 NN denotes gene
T5884 12136-12145 VBP denotes construct
T5885 12146-12149 VBD denotes was
T5886 12150-12160 RB denotes generously
T5887 12161-12169 VBN denotes provided
T5888 12170-12172 IN denotes by
T5889 12173-12175 NNP denotes J.
T5890 12176-12183 NNP denotes Hiscott
T5891 12184-12185 -LRB- denotes (
T5892 12185-12187 CD denotes 31
T5893 12187-12188 -RRB- denotes )
T5894 12188-12189 . denotes .
T5895 12190-12200 NNS denotes Constructs
T5896 12201-12205 VBD denotes were
T5897 12206-12216 VBN denotes methylated
T5898 12217-12219 IN denotes in
T5899 12220-12225 NN denotes vitro
T5900 12226-12230 IN denotes with
T5901 12231-12234 NNP denotes CpG
T5902 12235-12244 NNP denotes Methylase
T5903 12245-12246 -LRB- denotes (
T5904 12246-12251 NNP denotes M.Sss
T5905 12252-12253 PRP denotes I
T5906 12253-12254 -RRB- denotes )
T5907 12255-12257 IN denotes as
T5908 12258-12269 VBN denotes recommended
T5909 12270-12272 IN denotes by
T5910 12273-12276 DT denotes the
T5911 12277-12289 NN denotes manufacturer
T5912 12290-12291 -LRB- denotes (
T5913 12291-12293 NNP denotes NE
T5914 12294-12301 NNPS denotes Biolabs
T5915 12301-12302 -RRB- denotes )
T5916 12303-12306 CC denotes and
T5917 12307-12315 JJ denotes complete
T5918 12316-12327 NN denotes methylation
T5919 12328-12331 VBD denotes was
T5920 12332-12339 VBN denotes checked
T5921 12340-12343 IN denotes via
T5922 12344-12355 NN denotes restriction
T5923 12356-12364 NN denotes analysis
T5924 12365-12366 -LRB- denotes (
T5925 12366-12372 NN denotes Figure
T5926 12373-12375 NN denotes 5A
T5927 12375-12376 -RRB- denotes )
T5928 12376-12377 . denotes .
T5929 12378-12386 NN denotes Reporter
T5930 12387-12391 NN denotes gene
T5931 12392-12398 NNS denotes assays
T5932 12399-12404 VBG denotes using
T5933 12405-12408 DT denotes the
T5934 12409-12413 JJ denotes dual
T5935 12414-12424 NN denotes luciferase
T5936 12425-12430 NN denotes assay
T5937 12431-12432 -LRB- denotes (
T5938 12432-12439 NNP denotes Promega
T5939 12439-12440 -RRB- denotes )
T5940 12441-12445 VBD denotes were
T5941 12446-12455 VBN denotes performed
T5942 12456-12463 JJ denotes similar
T5943 12464-12466 TO denotes to
T5944 12467-12475 JJ denotes previous
T5945 12476-12483 NNS denotes reports
T5946 12484-12485 -LRB- denotes (
T5947 12485-12487 CD denotes 29
T5948 12487-12488 -RRB- denotes )
T5949 12488-12489 . denotes .
T5950 12490-12497 RB denotes Briefly
T5951 12497-12498 , denotes ,
T5952 12499-12500 CD denotes 5
T5953 12501-12503 NN denotes nM
T5954 12504-12506 IN denotes of
T5955 12507-12510 DT denotes the
T5956 12511-12519 NN denotes reporter
T5957 12520-12529 VB denotes construct
T5958 12530-12533 CC denotes and
T5959 12534-12537 DT denotes the
T5960 12538-12550 NN denotes transfection
T5961 12551-12558 NN denotes control
T5962 12559-12568 VBP denotes construct
T5963 12569-12579 VBG denotes expressing
T5964 12580-12583 DT denotes the
T5965 12584-12591 NN denotes renilla
T5966 12592-12602 NN denotes luciferase
T5967 12603-12607 NN denotes gene
T5968 12608-12612 VBD denotes were
T5969 12613-12636 JJ denotes transientlyco-expressed
T5970 12637-12640 IN denotes via
T5971 12641-12656 NN denotes electroporation
T5972 12656-12657 . denotes .
T5973 12658-12661 DT denotes The
T5974 12662-12669 NN denotes control
T5975 12670-12679 VBP denotes construct
T5976 12680-12686 VBN denotes served
T5977 12687-12689 IN denotes as
T5978 12690-12692 DT denotes an
T5979 12693-12701 JJ denotes internal
T5980 12702-12711 NN denotes reference
T5981 12712-12715 IN denotes for
T5982 12716-12728 NN denotes transfection
T5983 12729-12739 NN denotes efficiency
T5984 12739-12740 . denotes .
T5985 12741-12752 JJ denotes Forty-eight
T5986 12753-12758 NNS denotes hours
T5987 12759-12764 IN denotes after
T5988 12765-12777 NN denotes transfection
T5989 12777-12778 , denotes ,
T5990 12779-12789 NN denotes luciferase
T5991 12790-12798 NN denotes activity
T5992 12799-12802 VBD denotes was
T5993 12803-12811 VBN denotes measured
T5994 12812-12816 IN denotes with
T5995 12817-12818 DT denotes a
T5996 12819-12821 NNP denotes LB
T5997 12822-12824 CD denotes 96
T5998 12825-12826 NNP denotes P
T5999 12827-12837 NN denotes microlumat
T6000 12838-12839 -LRB- denotes (
T6001 12839-12843 NNP denotes EG&G
T6002 12844-12852 NNP denotes Berthold
T6003 12852-12853 , denotes ,
T6004 12854-12857 NNP denotes Bad
T6005 12858-12865 NNP denotes Wildbad
T6006 12865-12866 , denotes ,
T6007 12867-12874 NNP denotes Germany
T6008 12874-12875 -RRB- denotes )
T6009 12875-12876 . denotes .
T6010 12877-12882 CD denotes IRF-4
T6011 12883-12891 NN denotes promoter
T6012 12892-12902 NN denotes activation
T6013 12903-12906 VBD denotes was
T6014 12907-12917 VBN denotes quantified
T6015 12918-12920 IN denotes as
T6016 12921-12922 DT denotes a
T6017 12923-12928 NN denotes ratio
T6018 12929-12931 IN denotes of
T6019 12932-12940 VBN denotes measured
T6020 12941-12948 RB denotes firefly
T6021 12949-12954 JJ denotes light
T6022 12955-12960 NNS denotes units
T6023 12961-12962 -LRB- denotes (
T6024 12962-12965 NN denotes flu
T6025 12965-12966 -RRB- denotes )
T6026 12967-12975 JJ denotes relative
T6027 12976-12978 TO denotes to
T6028 12979-12986 NN denotes renilla
T6029 12987-12988 -LRB- denotes (
T6030 12988-12991 NN denotes rlu
T6031 12991-12992 -RRB- denotes )
T6032 12992-12993 . denotes .
T6033 12994-12998 DT denotes Each
T6034 12999-13009 NN denotes experiment
T6035 13010-13013 VBD denotes was
T6036 13014-13021 VBN denotes carried
T6037 13022-13025 RP denotes out
T6038 13026-13028 IN denotes at
T6039 13029-13034 JJS denotes least
T6040 13035-13040 CD denotes three
T6041 13041-13046 NNS denotes times
T6042 13046-13047 . denotes .
T6468 13058-13065 NN denotes Absence
T6469 13066-13068 IN denotes of
T6470 13069-13074 NN denotes IRF-4
T6471 13075-13085 NN denotes expression
T6472 13086-13088 IN denotes in
T6473 13089-13097 NN denotes leukemia
T6474 13098-13103 NNS denotes cells
T6475 13104-13106 VBZ denotes is
T6476 13107-13110 RB denotes not
T6477 13111-13114 JJ denotes due
T6478 13115-13117 TO denotes to
T6479 13118-13126 NN denotes promoter
T6480 13127-13138 NNS denotes alterations
T6481 13139-13141 PRP denotes We
T6482 13142-13146 VBP denotes have
T6483 13147-13157 RB denotes previously
T6484 13158-13170 VBN denotes demonstrated
T6485 13171-13172 DT denotes a
T6486 13173-13177 NN denotes lack
T6487 13178-13180 IN denotes of
T6488 13181-13186 NN denotes IRF-4
T6489 13187-13197 NN denotes expression
T6490 13198-13200 IN denotes in
T6491 13201-13209 NN denotes leukemia
T6492 13210-13218 NNS denotes patients
T6493 13219-13222 CC denotes and
T6494 13223-13235 RB denotes specifically
T6495 13236-13238 IN denotes in
T6496 13239-13242 NNP denotes CML
T6497 13243-13250 NNS denotes T-cells
T6498 13251-13252 -LRB- denotes (
T6499 13252-13253 CD denotes 3
T6500 13253-13254 -RRB- denotes )
T6501 13254-13255 . denotes .
T6502 13256-13260 RB denotes Here
T6503 13260-13261 , denotes ,
T6504 13262-13264 PRP denotes we
T6505 13265-13276 VBP denotes demonstrate
T6506 13277-13280 DT denotes the
T6507 13281-13288 NN denotes absence
T6508 13289-13291 IN denotes of
T6509 13292-13297 NN denotes IRF-4
T6510 13298-13308 NN denotes expression
T6511 13309-13311 IN denotes in
T6512 13312-13319 JJ denotes various
T6513 13320-13333 JJ denotes hematopoietic
T6514 13334-13338 NN denotes cell
T6515 13339-13344 NNS denotes lines
T6516 13344-13345 , denotes ,
T6517 13346-13350 JJ denotes such
T6518 13351-13353 IN denotes as
T6519 13354-13360 NNP denotes Jurkat
T6520 13360-13361 , denotes ,
T6521 13362-13363 DT denotes a
T6522 13364-13370 NNP denotes T-cell
T6523 13371-13379 NN denotes leukemia
T6524 13379-13380 , denotes ,
T6525 13381-13387 NNP denotes CML-T1
T6526 13387-13388 , denotes ,
T6527 13389-13390 DT denotes a
T6528 13391-13407 JJ denotes bcr-abl-positive
T6529 13408-13414 NNP denotes T-cell
T6530 13415-13419 NN denotes line
T6531 13419-13420 , denotes ,
T6532 13421-13426 NNP denotes K-562
T6533 13426-13427 , denotes ,
T6534 13428-13429 DT denotes a
T6535 13430-13445 JJ denotes bcr-abl-positve
T6536 13446-13461 NN denotes erythroleukemia
T6537 13461-13462 , denotes ,
T6538 13463-13468 NNP denotes U-937
T6539 13468-13469 , denotes ,
T6540 13470-13471 DT denotes a
T6541 13472-13481 JJ denotes monocytic
T6542 13482-13490 NN denotes leukemia
T6543 13490-13491 , denotes ,
T6544 13492-13496 NN denotes EM-2
T6545 13497-13500 CC denotes and
T6546 13501-13508 NN denotes LAMA-84
T6547 13508-13509 , denotes ,
T6548 13510-13525 JJ denotes bcr-abl-positve
T6549 13526-13533 JJ denotes myeloid
T6550 13534-13542 NN denotes leukemia
T6551 13542-13543 , denotes ,
T6552 13544-13547 CC denotes but
T6553 13548-13551 RB denotes not
T6554 13552-13554 IN denotes in
T6555 13555-13559 NN denotes SD-1
T6556 13559-13560 , denotes ,
T6557 13561-13562 DT denotes a
T6558 13563-13579 JJ denotes bcr-abl-positive
T6559 13580-13585 JJ denotes acute
T6560 13586-13599 JJ denotes lymphoblastic
T6561 13600-13608 NN denotes leukemia
T6562 13609-13610 -LRB- denotes (
T6563 13610-13613 FW denotes pre
T6564 13614-13619 NNP denotes B-ALL
T6565 13619-13620 -RRB- denotes )
T6566 13620-13621 , denotes ,
T6567 13622-13631 NNP denotes RPMI-8226
T6568 13631-13632 , denotes ,
T6569 13633-13634 DT denotes a
T6570 13635-13643 JJ denotes multiple
T6571 13644-13651 NN denotes myeloma
T6572 13652-13655 CC denotes and
T6573 13656-13662 NN denotes BV-173
T6574 13662-13663 , denotes ,
T6575 13664-13665 DT denotes a
T6576 13666-13682 JJ denotes bcr-abl-positive
T6577 13683-13689 NNP denotes B-cell
T6578 13690-13694 NN denotes line
T6579 13695-13696 -LRB- denotes (
T6580 13696-13703 NNS denotes Figures
T6581 13704-13706 NNP denotes 1A
T6582 13707-13710 CC denotes and
T6583 13711-13713 NNP denotes 5D
T6584 13713-13714 -RRB- denotes )
T6585 13714-13715 . denotes .
T6586 13716-13721 IN denotes After
T6587 13722-13732 VBG denotes sequencing
T6588 13733-13735 IN denotes of
T6589 13736-13739 DT denotes the
T6590 13740-13745 NN denotes IRF-4
T6591 13746-13754 NN denotes promoter
T6592 13754-13755 , denotes ,
T6593 13756-13758 PRP denotes it
T6594 13759-13764 MD denotes could
T6595 13765-13767 VB denotes be
T6596 13768-13776 VBN denotes excluded
T6597 13777-13781 IN denotes that
T6598 13782-13789 NN denotes absence
T6599 13790-13792 IN denotes of
T6600 13793-13798 NN denotes IRF-4
T6601 13799-13809 NN denotes expression
T6602 13810-13812 IN denotes in
T6603 13813-13816 DT denotes any
T6604 13817-13819 IN denotes of
T6605 13820-13823 DT denotes the
T6606 13824-13829 JJ denotes above
T6607 13830-13834 NN denotes cell
T6608 13835-13840 NNS denotes lines
T6609 13841-13844 VBD denotes was
T6610 13845-13848 JJ denotes due
T6611 13849-13851 TO denotes to
T6612 13852-13859 JJ denotes genetic
T6613 13860-13871 NNS denotes aberrations
T6614 13871-13872 . denotes .
T6615 13873-13880 RB denotes However
T6616 13880-13881 , denotes ,
T6617 13882-13883 CD denotes 2
T6618 13884-13886 NN denotes bp
T6619 13887-13894 NNS denotes changes
T6620 13895-13896 -LRB- denotes (
T6621 13896-13906 JJ denotes nucleotide
T6622 13907-13908 NN denotes −
T6623 13908-13912 CD denotes 1081
T6624 13912-13913 , denotes ,
T6625 13914-13915 NNP denotes T
T6626 13915-13916 VBD denotes →
T6627 13916-13917 NNP denotes C
T6628 13918-13921 CC denotes and
T6629 13922-13923 NNP denotes −
T6630 13923-13927 CD denotes 1068
T6631 13927-13928 , denotes ,
T6632 13929-13930 DT denotes A
T6633 13930-13931 NN denotes →
T6634 13931-13932 NNP denotes C
T6635 13932-13933 -RRB- denotes )
T6636 13934-13939 MD denotes could
T6637 13940-13942 VB denotes be
T6638 13943-13951 VBN denotes detected
T6639 13952-13954 IN denotes in
T6640 13955-13959 DT denotes both
T6641 13960-13963 DT denotes the
T6642 13964-13978 JJ denotes IRF-4-positive
T6643 13979-13985 NN denotes BV-173
T6644 13986-13989 CC denotes and
T6645 13990-13993 DT denotes the
T6646 13994-14008 JJ denotes IRF-4-negative
T6647 14009-14016 NN denotes LAMA-84
T6648 14016-14017 , denotes ,
T6649 14018-14022 NN denotes EM-2
T6650 14023-14026 CC denotes and
T6651 14027-14032 NN denotes K-562
T6652 14033-14034 -LRB- denotes (
T6653 14034-14040 NN denotes Figure
T6654 14041-14043 NN denotes 1B
T6655 14043-14044 -RRB- denotes )
T6656 14044-14045 . denotes .
T6657 14046-14048 IN denotes At
T6658 14049-14057 NN denotes position
T6659 14058-14059 NN denotes −
T6660 14059-14062 CD denotes 116
T6661 14063-14065 DT denotes an
T6662 14066-14067 DT denotes A
T6663 14067-14068 NN denotes →
T6664 14068-14069 NNP denotes C
T6665 14070-14082 NN denotes substitution
T6666 14083-14086 VBD denotes was
T6667 14087-14092 VBN denotes found
T6668 14093-14095 IN denotes in
T6669 14096-14100 NNP denotes EM-2
T6670 14100-14101 , denotes ,
T6671 14102-14107 NNP denotes K-562
T6672 14108-14111 CC denotes and
T6673 14112-14118 NNP denotes CML-T1
T6674 14118-14119 , denotes ,
T6675 14120-14127 IN denotes whereas
T6676 14128-14134 NNP denotes Jurkat
T6677 14134-14135 , denotes ,
T6678 14136-14142 NNP denotes BV-173
T6679 14143-14146 CC denotes and
T6680 14147-14151 NNP denotes SD-1
T6681 14152-14161 VBD denotes exhibited
T6682 14162-14163 DT denotes a
T6683 14164-14169 JJ denotes mixed
T6684 14170-14173 NNP denotes A/C
T6685 14174-14182 NN denotes sequence
T6686 14183-14186 CC denotes and
T6687 14187-14192 NNP denotes U-937
T6688 14192-14193 , denotes ,
T6689 14194-14201 NNP denotes LAMA-84
T6690 14202-14205 CC denotes and
T6691 14206-14215 NNP denotes RPMI-8226
T6692 14216-14218 DT denotes no
T6693 14219-14231 NN denotes substitution
T6694 14232-14234 IN denotes at
T6695 14235-14238 DT denotes all
T6696 14239-14240 -LRB- denotes (
T6697 14240-14246 NN denotes Figure
T6698 14247-14249 NN denotes 1B
T6699 14249-14250 -RRB- denotes )
T6700 14250-14251 . denotes .
T6701 14252-14264 RB denotes Consequently
T6702 14264-14265 , denotes ,
T6703 14266-14271 DT denotes these
T6704 14272-14283 NNS denotes alterations
T6705 14284-14287 VBP denotes are
T6706 14288-14296 JJ denotes unlikely
T6707 14297-14299 TO denotes to
T6708 14300-14306 VB denotes affect
T6709 14307-14312 JJ denotes IRF-4
T6710 14313-14323 NN denotes expression
T6711 14323-14324 . denotes .
T7315 14326-14334 VB denotes Increase
T7316 14335-14337 IN denotes of
T7317 14338-14343 NN denotes IRF-4
T7318 14344-14354 NN denotes expression
T7319 14355-14357 IN denotes in
T7320 14358-14371 JJ denotes hematopoietic
T7321 14372-14377 NNS denotes cells
T7322 14378-14383 IN denotes after
T7323 14384-14397 VBG denotes demethylating
T7324 14398-14407 NN denotes treatment
T7325 14408-14410 PRP denotes We
T7326 14411-14415 JJ denotes next
T7327 14416-14424 VBD denotes analyzed
T7328 14425-14432 IN denotes whether
T7329 14433-14441 NN denotes promoter
T7330 14442-14453 NN denotes methylation
T7331 14454-14459 MD denotes could
T7332 14460-14462 VB denotes be
T7333 14463-14474 JJ denotes responsible
T7334 14475-14478 IN denotes for
T7335 14479-14494 NN denotes down-regulation
T7336 14495-14497 IN denotes of
T7337 14498-14503 NN denotes IRF-4
T7338 14504-14514 NN denotes expression
T7339 14514-14515 . denotes .
T7340 14516-14517 DT denotes A
T7341 14518-14524 NN denotes region
T7342 14525-14534 VBG denotes including
T7343 14535-14540 CD denotes exon1
T7344 14541-14543 IN denotes in
T7345 14544-14547 DT denotes the
T7346 14548-14553 NN denotes IRF-4
T7347 14554-14562 NN denotes promoter
T7348 14563-14572 VBD denotes exhibited
T7349 14573-14574 DT denotes a
T7350 14575-14580 JJ denotes large
T7351 14581-14587 NN denotes number
T7352 14588-14590 IN denotes of
T7353 14591-14599 NNP denotes CpG-rich
T7354 14600-14609 NNS denotes sequences
T7355 14610-14611 -LRB- denotes (
T7356 14611-14617 NN denotes Figure
T7357 14618-14620 NN denotes 3A
T7358 14620-14621 -RRB- denotes )
T7359 14621-14622 . denotes .
T7360 14623-14630 JJ denotes Several
T7361 14631-14639 NN denotes chemical
T7362 14640-14650 NNS denotes substances
T7363 14651-14655 JJ denotes such
T7364 14656-14658 IN denotes as
T7365 14659-14680 JJ denotes 5-aza-2-deoxycytidine
T7366 14681-14682 -LRB- denotes (
T7367 14682-14687 NNP denotes AzadC
T7368 14687-14688 -RRB- denotes )
T7369 14689-14691 CC denotes or
T7370 14692-14705 JJ denotes 5-azacytidine
T7371 14706-14707 -LRB- denotes (
T7372 14707-14711 NNP denotes AzaC
T7373 14711-14712 -RRB- denotes )
T7374 14713-14720 VBP denotes inhibit
T7375 14721-14723 IN denotes de
T7376 14724-14728 NN denotes novo
T7377 14729-14732 CC denotes and
T7378 14733-14744 NN denotes maintenance
T7379 14745-14756 NN denotes methylation
T7380 14756-14757 , denotes ,
T7381 14758-14761 CC denotes and
T7382 14762-14766 RB denotes thus
T7383 14767-14770 MD denotes can
T7384 14771-14773 VB denotes be
T7385 14774-14778 VBN denotes used
T7386 14779-14781 TO denotes to
T7387 14782-14789 VB denotes discern
T7388 14790-14798 NN denotes promoter
T7389 14799-14810 NN denotes methylation
T7390 14811-14812 -LRB- denotes (
T7391 14812-14817 CD denotes 32,33
T7392 14817-14818 -RRB- denotes )
T7393 14818-14819 . denotes .
T7394 14820-14822 PRP denotes We
T7395 14823-14827 VBD denotes used
T7396 14828-14833 NNP denotes AzadC
T7397 14834-14836 TO denotes to
T7398 14837-14845 VB denotes generate
T7399 14846-14858 JJ denotes unmethylated
T7400 14859-14862 NN denotes DNA
T7401 14862-14863 . denotes .
T7402 14864-14865 DT denotes A
T7403 14866-14868 CD denotes 72
T7404 14869-14870 NN denotes h
T7405 14871-14886 NNP denotes AzadC-treatment
T7406 14887-14895 VBD denotes resulted
T7407 14896-14898 IN denotes in
T7408 14899-14900 DT denotes a
T7409 14901-14924 JJ denotes concentration-dependent
T7410 14925-14935 NN denotes activation
T7411 14936-14938 IN denotes of
T7412 14939-14944 NN denotes IRF-4
T7413 14945-14958 NN denotes transcription
T7414 14959-14961 IN denotes in
T7415 14962-14968 NNP denotes Jurkat
T7416 14969-14972 CC denotes and
T7417 14973-14979 NNP denotes CML-T1
T7418 14980-14987 NNS denotes T-cells
T7419 14988-14990 RB denotes as
T7420 14991-14995 RB denotes well
T7421 14996-14998 IN denotes as
T7422 14999-15001 IN denotes in
T7423 15002-15007 NNP denotes U-937
T7424 15007-15008 , denotes ,
T7425 15009-15014 NNP denotes K-562
T7426 15015-15018 CC denotes and
T7427 15019-15023 NNP denotes EM-2
T7428 15024-15028 NN denotes cell
T7429 15029-15034 NNS denotes lines
T7430 15035-15036 -LRB- denotes (
T7431 15036-15042 NN denotes Figure
T7432 15043-15045 NN denotes 2A
T7433 15045-15046 -RRB- denotes )
T7434 15046-15047 . denotes .
T7435 15048-15053 CD denotes IRF-4
T7436 15054-15067 NN denotes transcription
T7437 15068-15071 VBD denotes was
T7438 15072-15079 VBN denotes induced
T7439 15080-15082 IN denotes in
T7440 15083-15084 DT denotes a
T7441 15085-15099 JJ denotes time-dependent
T7442 15100-15106 NN denotes manner
T7443 15107-15110 CC denotes and
T7444 15111-15114 VBD denotes was
T7445 15115-15123 VBN denotes observed
T7446 15124-15126 RB denotes as
T7447 15127-15132 RB denotes early
T7448 15133-15135 IN denotes as
T7449 15136-15138 CD denotes 24
T7450 15139-15140 NN denotes h
T7451 15141-15146 IN denotes after
T7452 15147-15156 NN denotes treatment
T7453 15157-15161 IN denotes with
T7454 15162-15167 NNP denotes AzadC
T7455 15168-15171 CC denotes and
T7456 15172-15181 VBD denotes increased
T7457 15182-15186 IN denotes over
T7458 15187-15191 NN denotes time
T7459 15192-15197 IN denotes until
T7460 15198-15200 CD denotes 72
T7461 15201-15202 NN denotes h
T7462 15203-15204 -LRB- denotes (
T7463 15204-15210 NN denotes Figure
T7464 15211-15213 NN denotes 2B
T7465 15213-15214 -RRB- denotes )
T7466 15214-15215 . denotes .
T7467 15216-15220 NNP denotes Time
T7468 15221-15224 CC denotes and
T7469 15225-15233 NN denotes strength
T7470 15234-15236 IN denotes of
T7471 15237-15240 DT denotes the
T7472 15241-15251 NN denotes appearance
T7473 15252-15254 IN denotes of
T7474 15255-15260 NN denotes IRF-4
T7475 15261-15272 NNS denotes transcripts
T7476 15273-15279 VBD denotes varied
T7477 15280-15285 IN denotes among
T7478 15286-15290 NN denotes cell
T7479 15291-15296 NNS denotes lines
T7480 15296-15297 , denotes ,
T7481 15298-15302 FW denotes i.e.
T7482 15303-15309 NN denotes CML-T1
T7483 15310-15319 VBD denotes responded
T7484 15320-15329 JJS denotes strongest
T7485 15330-15332 TO denotes to
T7486 15333-15348 NNP denotes AzadC-treatment
T7487 15349-15350 -LRB- denotes (
T7488 15350-15354 NNS denotes data
T7489 15355-15358 RB denotes not
T7490 15359-15364 VBN denotes shown
T7491 15364-15365 -RRB- denotes )
T7492 15365-15366 . denotes .
T7493 15367-15369 IN denotes In
T7494 15370-15374 NN denotes line
T7495 15375-15379 IN denotes with
T7496 15380-15384 DT denotes this
T7497 15384-15385 , denotes ,
T7498 15386-15401 NNP denotes AzadC-treatment
T7499 15402-15404 IN denotes of
T7500 15405-15411 NNP denotes CML-T1
T7501 15412-15415 CC denotes and
T7502 15416-15423 NNP denotes LAMA-84
T7503 15424-15429 NNS denotes cells
T7504 15430-15434 RB denotes also
T7505 15435-15445 VBN denotes translated
T7506 15446-15448 IN denotes in
T7507 15449-15451 DT denotes an
T7508 15452-15461 NN denotes induction
T7509 15462-15464 IN denotes of
T7510 15465-15470 NN denotes IRF-4
T7511 15471-15478 NN denotes protein
T7512 15479-15489 NN denotes expression
T7513 15490-15491 -LRB- denotes (
T7514 15491-15497 NN denotes Figure
T7515 15498-15500 CD denotes 2C
T7516 15500-15501 -RRB- denotes )
T7517 15501-15502 . denotes .
T7518 15503-15514 RB denotes Accordingly
T7519 15514-15515 , denotes ,
T7520 15516-15525 NN denotes treatment
T7521 15526-15528 IN denotes of
T7522 15529-15532 DT denotes the
T7523 15533-15547 JJ denotes IRF-4-positive
T7524 15548-15552 NN denotes cell
T7525 15553-15557 NN denotes line
T7526 15558-15564 NN denotes BV-173
T7527 15564-15565 , denotes ,
T7528 15566-15570 NN denotes SD-1
T7529 15571-15574 CC denotes and
T7530 15575-15584 NN denotes RPMI-8226
T7531 15585-15589 IN denotes with
T7532 15590-15595 NNP denotes AzadC
T7533 15596-15599 VBD denotes had
T7534 15600-15602 DT denotes no
T7535 15603-15609 NN denotes effect
T7536 15610-15612 IN denotes on
T7537 15613-15618 NN denotes IRF-4
T7538 15619-15629 NN denotes expression
T7539 15630-15631 -LRB- denotes (
T7540 15631-15637 NN denotes Figure
T7541 15638-15640 CD denotes 2D
T7542 15640-15641 -RRB- denotes )
T7543 15641-15642 . denotes .
T7544 15643-15648 EX denotes There
T7545 15649-15652 VBD denotes was
T7546 15653-15655 DT denotes no
T7547 15656-15666 NN denotes difference
T7548 15667-15669 IN denotes in
T7549 15670-15673 DT denotes the
T7550 15674-15681 NNS denotes effects
T7551 15682-15684 IN denotes of
T7552 15685-15689 NNP denotes AzaC
T7553 15690-15696 CC denotes versus
T7554 15697-15702 NNP denotes AzadC
T7555 15702-15703 , denotes ,
T7556 15704-15706 IN denotes as
T7557 15707-15711 DT denotes both
T7558 15712-15721 VBD denotes increased
T7559 15722-15725 DT denotes the
T7560 15726-15731 NNP denotes IRF-4
T7561 15732-15736 NNP denotes mRNA
T7562 15737-15742 NN denotes level
T7563 15743-15745 IN denotes in
T7564 15746-15752 NNP denotes CML-T1
T7565 15753-15758 NNS denotes cells
T7566 15759-15761 RB denotes as
T7567 15762-15766 RB denotes well
T7568 15767-15768 -LRB- denotes (
T7569 15768-15772 NNS denotes data
T7570 15773-15776 RB denotes not
T7571 15777-15782 VBN denotes shown
T7572 15782-15783 -RRB- denotes )
T7573 15783-15784 . denotes .
T7574 15785-15789 DT denotes This
T7575 15790-15797 VBD denotes implied
T7576 15798-15802 IN denotes that
T7577 15803-15811 NN denotes promoter
T7578 15812-15823 NN denotes methylation
T7579 15824-15827 MD denotes may
T7580 15828-15835 VB denotes control
T7581 15836-15841 JJ denotes IRF-4
T7582 15842-15852 NN denotes expression
T7583 15852-15853 , denotes ,
T7584 15854-15857 CC denotes but
T7585 15858-15860 DT denotes an
T7586 15861-15872 JJ denotes alternative
T7587 15873-15884 NN denotes explanation
T7588 15885-15888 MD denotes may
T7589 15889-15891 VB denotes be
T7590 15892-15902 NN denotes activation
T7591 15903-15905 IN denotes of
T7592 15906-15914 JJ denotes positive
T7593 15915-15930 JJ denotes transcriptional
T7594 15931-15941 NNS denotes regulators
T7595 15942-15944 IN denotes of
T7596 15945-15950 NN denotes IRF-4
T7597 15951-15953 IN denotes by
T7598 15954-15959 NNP denotes AzadC
T7599 15960-15961 -LRB- denotes (
T7600 15961-15963 CC denotes or
T7601 15964-15968 NNP denotes AzaC
T7602 15968-15969 -RRB- denotes )
T7603 15969-15970 . denotes .
T8113 15972-15993 JJ denotes Methylation-sensitive
T8114 15994-16001 NNS denotes enzymes
T8115 16002-16004 VBP denotes do
T8116 16005-16008 RB denotes not
T8117 16009-16012 VB denotes cut
T8118 16013-16021 JJ denotes specific
T8119 16022-16027 NNS denotes sites
T8120 16028-16030 IN denotes in
T8121 16031-16034 DT denotes the
T8122 16035-16040 NN denotes IRF-4
T8123 16041-16049 NN denotes promoter
T8124 16050-16052 IN denotes in
T8125 16053-16066 JJ denotes hematopoietic
T8126 16067-16072 NNS denotes cells
T8127 16073-16075 TO denotes To
T8128 16076-16083 RBR denotes further
T8129 16084-16095 VB denotes investigate
T8130 16096-16104 NN denotes promoter
T8131 16105-16116 NN denotes methylation
T8132 16117-16119 IN denotes as
T8133 16120-16121 DT denotes a
T8134 16122-16132 JJ denotes regulatory
T8135 16133-16142 NN denotes mechanism
T8136 16143-16145 IN denotes of
T8137 16146-16151 NNP denotes IRF-4
T8138 16152-16156 NN denotes gene
T8139 16157-16167 NN denotes expression
T8140 16167-16168 , denotes ,
T8141 16169-16191 NNPS denotes restriction-PCR-assays
T8142 16192-16196 VBD denotes were
T8143 16197-16206 VBN denotes performed
T8144 16207-16208 -LRB- denotes (
T8145 16208-16213 CD denotes 20,24
T8146 16213-16214 -RRB- denotes )
T8147 16214-16215 , denotes ,
T8148 16216-16221 WRB denotes where
T8149 16222-16226 RB denotes only
T8150 16227-16237 JJ denotes methylated
T8151 16238-16241 NN denotes DNA
T8152 16242-16247 MD denotes would
T8153 16248-16251 RB denotes not
T8154 16252-16254 VB denotes be
T8155 16255-16258 VBN denotes cut
T8156 16259-16267 VBG denotes enabling
T8157 16268-16278 JJ denotes subsequent
T8158 16279-16282 NNP denotes PCR
T8159 16283-16296 NN denotes amplification
T8160 16297-16300 CC denotes and
T8161 16301-16305 NN denotes vice
T8162 16306-16311 RB denotes versa
T8163 16311-16312 . denotes .
T8164 16313-16320 NNP denotes Genomic
T8165 16321-16324 NNP denotes DNA
T8166 16325-16329 IN denotes from
T8167 16330-16338 JJ denotes leukemic
T8168 16339-16344 NNS denotes cells
T8169 16345-16351 NNP denotes Jurkat
T8170 16351-16352 , denotes ,
T8171 16353-16359 NNP denotes CML-T1
T8172 16359-16360 , denotes ,
T8173 16361-16366 NNP denotes U-937
T8174 16366-16367 , denotes ,
T8175 16368-16373 NNP denotes K-562
T8176 16373-16374 , denotes ,
T8177 16375-16379 NNP denotes EM-2
T8178 16380-16383 CC denotes and
T8179 16384-16390 NNP denotes BV-173
T8180 16391-16394 VBD denotes was
T8181 16395-16403 VBN denotes digested
T8182 16404-16408 IN denotes with
T8183 16409-16412 DT denotes the
T8184 16413-16434 JJ denotes methylation-sensitive
T8185 16435-16442 NNS denotes enzymes
T8186 16443-16448 NNP denotes HpaII
T8187 16448-16449 , denotes ,
T8188 16450-16458 NNP denotes Bsh1236I
T8189 16459-16462 CC denotes and
T8190 16463-16480 NNP denotes HaeII-isochizomer
T8191 16481-16489 NNP denotes Bsp143II
T8192 16489-16490 . denotes .
T8193 16491-16496 NNP denotes EcoRI
T8194 16496-16497 , denotes ,
T8195 16498-16503 WDT denotes which
T8196 16504-16507 VBZ denotes has
T8197 16508-16510 DT denotes no
T8198 16511-16522 NN denotes recognition
T8199 16523-16527 NN denotes site
T8200 16528-16534 IN denotes within
T8201 16535-16538 DT denotes the
T8202 16539-16544 NN denotes IRF-4
T8203 16545-16553 NN denotes promoter
T8204 16553-16554 , denotes ,
T8205 16555-16558 CC denotes and
T8206 16559-16562 DT denotes the
T8207 16563-16584 JJ denotes methylation-resistant
T8208 16585-16591 NN denotes enzyme
T8209 16592-16596 NNP denotes MspI
T8210 16597-16603 VBD denotes served
T8211 16604-16606 IN denotes as
T8212 16607-16615 NNS denotes controls
T8213 16615-16616 . denotes .
T8214 16617-16620 CD denotes Two
T8215 16621-16629 JJ denotes separate
T8216 16630-16643 NN denotes amplification
T8217 16644-16653 NNS denotes reactions
T8218 16654-16658 VBD denotes were
T8219 16659-16668 VBN denotes performed
T8220 16668-16669 , denotes ,
T8221 16670-16680 VBG denotes generating
T8222 16681-16684 CD denotes two
T8223 16685-16694 NNS denotes fragments
T8224 16694-16695 , denotes ,
T8225 16696-16698 NNP denotes F1
T8226 16699-16702 CC denotes and
T8227 16703-16705 NNP denotes F2
T8228 16706-16707 -LRB- denotes (
T8229 16707-16713 NNP denotes Figure
T8230 16714-16716 NNP denotes 3A
T8231 16716-16717 -RRB- denotes )
T8232 16717-16718 . denotes .
T8233 16719-16724 IN denotes After
T8234 16725-16734 NN denotes digestion
T8235 16735-16739 IN denotes with
T8236 16740-16745 NNP denotes HpaII
T8237 16746-16749 CC denotes and
T8238 16750-16758 NNP denotes Bsp143II
T8239 16759-16760 DT denotes a
T8240 16761-16771 JJ denotes sufficient
T8241 16772-16775 NNP denotes PCR
T8242 16776-16789 NN denotes amplification
T8243 16790-16792 IN denotes of
T8244 16793-16795 CD denotes F1
T8245 16796-16799 CC denotes and
T8246 16800-16802 CD denotes F2
T8247 16803-16806 VBD denotes was
T8248 16807-16815 VBN denotes detected
T8249 16816-16818 IN denotes in
T8250 16819-16822 NNP denotes DNA
T8251 16823-16827 IN denotes from
T8252 16828-16842 JJ denotes IRF-4-negative
T8253 16843-16849 NNP denotes Jurkat
T8254 16849-16850 , denotes ,
T8255 16851-16857 NNP denotes CML-T1
T8256 16857-16858 , denotes ,
T8257 16859-16864 NNP denotes U-937
T8258 16864-16865 , denotes ,
T8259 16866-16871 NNP denotes K-562
T8260 16872-16875 CC denotes and
T8261 16876-16880 NNP denotes EM-2
T8262 16881-16886 NNS denotes cells
T8263 16886-16887 , denotes ,
T8264 16888-16898 VBG denotes suggesting
T8265 16899-16900 DT denotes a
T8266 16901-16909 NN denotes promoter
T8267 16910-16921 NN denotes methylation
T8268 16922-16923 -LRB- denotes (
T8269 16923-16926 CC denotes and
T8270 16927-16938 NN denotes restriction
T8271 16939-16949 NN denotes protection
T8272 16949-16950 -RRB- denotes )
T8273 16951-16953 IN denotes at
T8274 16954-16957 DT denotes the
T8275 16958-16968 JJ denotes respective
T8276 16969-16980 NN denotes recognition
T8277 16981-16986 NNS denotes sites
T8278 16987-16988 -LRB- denotes (
T8279 16988-16994 NN denotes Figure
T8280 16995-16997 NN denotes 3B
T8281 16998-17001 CC denotes and
T8282 17002-17003 NNP denotes C
T8283 17003-17004 -RRB- denotes )
T8284 17004-17005 . denotes .
T8285 17006-17013 RB denotes Notably
T8286 17013-17014 , denotes ,
T8287 17015-17017 IN denotes in
T8288 17018-17032 JJ denotes IRF-4-positive
T8289 17033-17037 NN denotes SD-1
T8290 17038-17043 NNS denotes cells
T8291 17044-17053 NN denotes digestion
T8292 17054-17058 IN denotes with
T8293 17059-17062 DT denotes the
T8294 17063-17084 JJ denotes methylation-sensitive
T8295 17085-17092 NNS denotes enzymes
T8296 17093-17103 RB denotes completely
T8297 17104-17113 VBD denotes inhibited
T8298 17114-17127 NN denotes amplification
T8299 17128-17130 IN denotes of
T8300 17131-17133 CD denotes F1
T8301 17134-17137 CC denotes and
T8302 17138-17140 CD denotes F2
T8303 17140-17141 . denotes .
T8304 17142-17144 IN denotes In
T8305 17145-17159 JJ denotes IRF-4-positive
T8306 17160-17166 JJ denotes BV-173
T8307 17167-17172 NNS denotes cells
T8308 17173-17174 DT denotes a
T8309 17175-17180 NNP denotes HpaII
T8310 17180-17181 , denotes ,
T8311 17182-17185 CC denotes but
T8312 17186-17189 RB denotes not
T8313 17190-17191 DT denotes a
T8314 17192-17200 JJ denotes Bsh1236I
T8315 17201-17210 NN denotes digestion
T8316 17210-17211 , denotes ,
T8317 17212-17225 RB denotes significantly
T8318 17226-17233 VBD denotes reduced
T8319 17234-17237 DT denotes the
T8320 17238-17249 JJ denotes amplifiable
T8321 17250-17253 NNP denotes DNA
T8322 17254-17261 NN denotes message
T8323 17262-17264 IN denotes of
T8324 17265-17267 CD denotes F2
T8325 17268-17269 -LRB- denotes (
T8326 17269-17275 NN denotes Figure
T8327 17276-17278 NN denotes 3C
T8328 17278-17279 -RRB- denotes )
T8329 17279-17280 , denotes ,
T8330 17281-17288 IN denotes whereas
T8331 17289-17302 NN denotes amplification
T8332 17303-17305 IN denotes of
T8333 17306-17308 CD denotes F1
T8334 17309-17312 VBD denotes was
T8335 17313-17316 RB denotes not
T8336 17317-17325 VBN denotes affected
T8337 17326-17327 -LRB- denotes (
T8338 17327-17333 NN denotes Figure
T8339 17334-17336 NN denotes 3B
T8340 17336-17337 -RRB- denotes )
T8341 17337-17338 . denotes .
T8342 17339-17343 DT denotes This
T8343 17344-17351 VBD denotes implied
T8344 17352-17356 IN denotes that
T8345 17357-17362 JJ denotes IRF-4
T8346 17363-17376 NN denotes transcription
T8347 17377-17379 IN denotes in
T8348 17380-17384 NN denotes SD-1
T8349 17385-17388 CC denotes and
T8350 17389-17395 JJ denotes BV-173
T8351 17396-17401 NNS denotes cells
T8352 17402-17404 VBZ denotes is
T8353 17405-17415 VBN denotes associated
T8354 17416-17420 IN denotes with
T8355 17421-17425 JJR denotes less
T8356 17426-17434 NN denotes promoter
T8357 17435-17446 NN denotes methylation
T8358 17447-17448 -LRB- denotes (
T8359 17448-17450 IN denotes in
T8360 17451-17457 NN denotes BV-173
T8361 17458-17468 RB denotes especially
T8362 17469-17471 IN denotes at
T8363 17472-17477 NNP denotes HpaII
T8364 17478-17483 NNS denotes sites
T8365 17483-17484 -RRB- denotes )
T8366 17485-17487 IN denotes as
T8367 17488-17496 VBN denotes compared
T8368 17497-17501 IN denotes with
T8369 17502-17505 DT denotes the
T8370 17506-17512 VBN denotes tested
T8371 17513-17527 JJ denotes IRF-4-negative
T8372 17528-17533 NNS denotes cells
T8373 17533-17534 . denotes .
T9022 17536-17544 JJ denotes Specific
T9023 17545-17548 NNP denotes CpG
T9024 17549-17554 NNS denotes sites
T9025 17555-17557 IN denotes in
T9026 17558-17561 DT denotes the
T9027 17562-17567 NN denotes IRF-4
T9028 17568-17576 NN denotes promoter
T9029 17577-17580 VBP denotes are
T9030 17581-17591 VBN denotes methylated
T9031 17592-17594 IN denotes in
T9032 17595-17608 JJ denotes hematopoietic
T9033 17609-17614 NNS denotes cells
T9034 17615-17617 IN denotes In
T9035 17618-17623 NN denotes order
T9036 17624-17626 TO denotes to
T9037 17627-17634 RB denotes exactly
T9038 17635-17638 VB denotes map
T9039 17639-17642 DT denotes the
T9040 17643-17654 NN denotes methylation
T9041 17655-17660 NNS denotes sites
T9042 17661-17667 IN denotes within
T9043 17668-17671 DT denotes the
T9044 17672-17677 NN denotes IRF-4
T9045 17678-17686 NN denotes promoter
T9046 17686-17687 , denotes ,
T9047 17688-17690 PRP denotes we
T9048 17691-17698 VBD denotes treated
T9049 17699-17702 NNP denotes DNA
T9050 17703-17705 IN denotes of
T9051 17706-17712 NNP denotes Jurkat
T9052 17712-17713 , denotes ,
T9053 17714-17720 NNP denotes CML-T1
T9054 17720-17721 , denotes ,
T9055 17722-17727 NNP denotes U-937
T9056 17727-17728 , denotes ,
T9057 17729-17734 NNP denotes K-562
T9058 17735-17738 CC denotes and
T9059 17739-17743 NNP denotes EM-2
T9060 17744-17749 NNS denotes cells
T9061 17750-17752 RB denotes as
T9062 17753-17757 RB denotes well
T9063 17758-17760 IN denotes as
T9064 17761-17763 IN denotes of
T9065 17764-17768 NN denotes SD-1
T9066 17768-17769 , denotes ,
T9067 17770-17779 NN denotes RPMI-8226
T9068 17780-17783 CC denotes and
T9069 17784-17790 NN denotes BV-173
T9070 17791-17798 NN denotes control
T9071 17799-17804 NNS denotes cells
T9072 17805-17809 IN denotes with
T9073 17810-17819 NN denotes bisulfite
T9074 17819-17820 , denotes ,
T9075 17821-17826 WDT denotes which
T9076 17827-17837 RB denotes chemically
T9077 17838-17846 VBZ denotes converts
T9078 17847-17859 JJ denotes unmethylated
T9079 17860-17868 NN denotes cytosine
T9080 17869-17871 TO denotes to
T9081 17872-17878 VB denotes uracil
T9082 17878-17879 , denotes ,
T9083 17880-17887 IN denotes whereas
T9084 17888-17890 PRP denotes it
T9085 17891-17894 VBZ denotes has
T9086 17895-17897 DT denotes no
T9087 17898-17904 NN denotes effect
T9088 17905-17907 IN denotes on
T9089 17908-17918 JJ denotes methylated
T9090 17919-17927 NN denotes cytosine
T9091 17927-17928 , denotes ,
T9092 17929-17933 FW denotes i.e.
T9093 17934-17936 IN denotes in
T9094 17937-17940 NNP denotes CpG
T9095 17941-17942 -LRB- denotes (
T9096 17942-17944 CD denotes 34
T9097 17944-17945 -RRB- denotes )
T9098 17945-17946 . denotes .
T9099 17947-17951 DT denotes This
T9100 17952-17961 NN denotes technique
T9101 17962-17964 VBZ denotes is
T9102 17965-17975 RB denotes especially
T9103 17976-17982 JJ denotes useful
T9104 17983-17986 IN denotes for
T9105 17987-17996 NN denotes detection
T9106 17997-17999 IN denotes of
T9107 18000-18007 JJ denotes unknown
T9108 18008-18019 NN denotes methylation
T9109 18020-18028 NNS denotes patterns
T9110 18028-18029 . denotes .
T9111 18030-18033 NNP denotes PCR
T9112 18034-18047 NN denotes amplification
T9113 18047-18048 , denotes ,
T9114 18049-18056 VBG denotes cloning
T9115 18057-18060 CC denotes and
T9116 18061-18071 VBG denotes sequencing
T9117 18072-18074 IN denotes of
T9118 18075-18078 DT denotes the
T9119 18079-18096 JJ denotes bisulfite-treated
T9120 18097-18100 NN denotes DNA
T9121 18101-18107 VBD denotes showed
T9122 18108-18109 DT denotes a
T9123 18110-18118 JJ denotes specific
T9124 18119-18130 NN denotes methylation
T9125 18131-18138 NN denotes pattern
T9126 18139-18141 IN denotes of
T9127 18142-18145 DT denotes the
T9128 18146-18154 VBN denotes analyzed
T9129 18155-18157 CD denotes 62
T9130 18158-18161 NNP denotes CpG
T9131 18162-18167 NNS denotes sites
T9132 18168-18170 IN denotes in
T9133 18171-18174 DT denotes all
T9134 18175-18179 NN denotes cell
T9135 18180-18185 NNS denotes lines
T9136 18186-18187 -LRB- denotes (
T9137 18187-18193 NN denotes Figure
T9138 18194-18195 CD denotes 4
T9139 18196-18199 CC denotes and
T9140 18200-18205 NNP denotes Table
T9141 18206-18207 CD denotes 1
T9142 18207-18208 -RRB- denotes )
T9143 18208-18209 . denotes .
T9144 18210-18212 IN denotes In
T9145 18213-18220 JJ denotes general
T9146 18220-18221 , denotes ,
T9147 18222-18225 DT denotes the
T9148 18226-18239 JJ denotes methylational
T9149 18240-18246 NN denotes status
T9150 18247-18253 VBD denotes ranged
T9151 18254-18258 IN denotes from
T9152 18259-18262 CD denotes one
T9153 18263-18267 NN denotes cell
T9154 18268-18272 NN denotes line
T9155 18273-18277 IN denotes with
T9156 18278-18279 DT denotes a
T9157 18280-18286 RB denotes nearly
T9158 18287-18301 JJ denotes non-methylated
T9159 18302-18307 NN denotes IRF-4
T9160 18308-18316 NN denotes promoter
T9161 18317-18318 -LRB- denotes (
T9162 18318-18322 NN denotes SD-1
T9163 18322-18323 , denotes ,
T9164 18324-18338 JJ denotes IRF-4-positive
T9165 18338-18339 -RRB- denotes )
T9166 18340-18342 TO denotes to
T9167 18343-18344 DT denotes a
T9168 18345-18355 RB denotes completely
T9169 18356-18366 VBN denotes methylated
T9170 18367-18372 NN denotes IRF-4
T9171 18373-18381 NN denotes promoter
T9172 18382-18384 IN denotes in
T9173 18385-18391 NNP denotes CML-T1
T9174 18392-18393 -LRB- denotes (
T9175 18393-18407 JJ denotes IRF-4-negative
T9176 18407-18408 -RRB- denotes )
T9177 18408-18409 . denotes .
T9178 18410-18423 RB denotes Interestingly
T9179 18423-18424 , denotes ,
T9180 18425-18428 DT denotes the
T9181 18429-18439 NN denotes percentage
T9182 18440-18442 IN denotes of
T9183 18443-18446 NNP denotes CpG
T9184 18447-18458 NN denotes methylation
T9185 18459-18461 IN denotes in
T9186 18462-18465 DT denotes the
T9187 18466-18471 NN denotes IRF-4
T9188 18472-18480 NN denotes promoter
T9189 18481-18485 IN denotes from
T9190 18486-18500 JJ denotes IRF-4-positive
T9191 18501-18506 NNS denotes cells
T9192 18507-18510 VBD denotes was
T9193 18511-18515 RB denotes very
T9194 18516-18519 JJ denotes low
T9195 18520-18521 -LRB- denotes (
T9196 18521-18525 JJ denotes mean
T9197 18526-18528 CD denotes 24
T9198 18528-18529 NN denotes %
T9199 18529-18530 -RRB- denotes )
T9200 18531-18533 IN denotes as
T9201 18534-18542 VBN denotes compared
T9202 18543-18547 IN denotes with
T9203 18548-18562 JJ denotes IRF-4-negative
T9204 18563-18568 NNS denotes cells
T9205 18569-18570 -LRB- denotes (
T9206 18570-18574 VB denotes mean
T9207 18575-18577 CD denotes 94
T9208 18577-18578 NN denotes %
T9209 18578-18579 -RRB- denotes )
T9210 18580-18581 -LRB- denotes (
T9211 18581-18587 NN denotes Figure
T9212 18588-18590 NN denotes 4A
T9213 18591-18594 CC denotes and
T9214 18595-18600 NNP denotes Table
T9215 18601-18602 CD denotes 1
T9216 18602-18603 -RRB- denotes )
T9217 18603-18604 . denotes .
T9218 18605-18606 DT denotes A
T9219 18607-18608 CD denotes 5
T9220 18608-18609 SYM denotes ′
T9221 18609-18610 : denotes -
T9222 18610-18616 NN denotes region
T9223 18617-18618 -LRB- denotes (
T9224 18618-18620 CD denotes R1
T9225 18620-18621 -RRB- denotes )
T9226 18622-18626 IN denotes with
T9227 18627-18629 CD denotes 13
T9228 18630-18645 VBD denotes hypermethylated
T9229 18646-18649 NNP denotes CpG
T9230 18650-18655 NNS denotes sites
T9231 18656-18657 -LRB- denotes (
T9232 18657-18661 JJ denotes mean
T9233 18662-18668 NN denotes number
T9234 18669-18671 IN denotes of
T9235 18672-18682 JJ denotes methylated
T9236 18683-18689 NNS denotes clones
T9237 18690-18693 CD denotes 5.5
T9238 18694-18696 IN denotes of
T9239 18697-18698 CD denotes 8
T9240 18699-18703 IN denotes with
T9241 18704-18706 CD denotes 77
T9242 18706-18707 NN denotes %
T9243 18708-18718 VBD denotes methylated
T9244 18719-18723 NNS denotes CpGs
T9245 18723-18724 -RRB- denotes )
T9246 18725-18728 VBD denotes was
T9247 18729-18734 VBN denotes found
T9248 18735-18737 IN denotes in
T9249 18738-18742 JJS denotes most
T9250 18743-18748 NNS denotes cells
T9251 18749-18750 -LRB- denotes (
T9252 18750-18756 IN denotes except
T9253 18757-18761 NNP denotes SD-1
T9254 18762-18765 CC denotes and
T9255 18766-18775 NNP denotes RPMI-8226
T9256 18775-18776 -RRB- denotes )
T9257 18777-18780 CC denotes and
T9258 18781-18782 DT denotes a
T9259 18783-18784 CD denotes 3
T9260 18784-18785 SYM denotes ′
T9261 18785-18786 : denotes -
T9262 18786-18792 NN denotes region
T9263 18793-18794 -LRB- denotes (
T9264 18794-18796 CD denotes R3
T9265 18796-18797 -RRB- denotes )
T9266 18798-18800 IN denotes of
T9267 18801-18802 CD denotes 6
T9268 18803-18817 VBD denotes hypomethylated
T9269 18818-18821 NNP denotes CpG
T9270 18822-18827 NNS denotes sites
T9271 18828-18829 -LRB- denotes (
T9272 18829-18833 JJ denotes mean
T9273 18834-18840 NN denotes number
T9274 18841-18843 IN denotes of
T9275 18844-18854 JJ denotes methylated
T9276 18855-18861 NNS denotes clones
T9277 18862-18865 CD denotes 1.7
T9278 18866-18868 IN denotes of
T9279 18869-18870 CD denotes 8
T9280 18871-18875 IN denotes with
T9281 18876-18878 CD denotes 33
T9282 18878-18879 NN denotes %
T9283 18880-18890 VBD denotes methylated
T9284 18891-18895 NNS denotes CpGs
T9285 18895-18896 -RRB- denotes )
T9286 18897-18900 VBD denotes was
T9287 18901-18906 VBN denotes found
T9288 18907-18909 IN denotes in
T9289 18910-18914 JJS denotes most
T9290 18915-18920 NNS denotes cells
T9291 18921-18922 -LRB- denotes (
T9292 18922-18928 IN denotes except
T9293 18929-18935 NNP denotes CML-T1
T9294 18936-18939 CC denotes and
T9295 18940-18945 NNP denotes U-937
T9296 18945-18946 -RRB- denotes )
T9297 18947-18948 -LRB- denotes (
T9298 18948-18954 NN denotes Figure
T9299 18955-18957 NN denotes 4A
T9300 18958-18961 CC denotes and
T9301 18962-18967 NNP denotes Table
T9302 18968-18969 CD denotes 1
T9303 18969-18970 -RRB- denotes )
T9304 18970-18971 . denotes .
T9305 18972-18984 RB denotes Intriguingly
T9306 18984-18985 , denotes ,
T9307 18986-18987 DT denotes a
T9308 18988-18995 NN denotes stretch
T9309 18996-18998 IN denotes of
T9310 18999-19001 CD denotes 13
T9311 19002-19005 NNP denotes CpG
T9312 19006-19011 NNS denotes sites
T9313 19012-19013 -LRB- denotes (
T9314 19013-19014 # denotes #
T9315 19014-19016 CD denotes 10
T9316 19017-19019 CD denotes 22
T9317 19019-19020 : denotes ;
T9318 19021-19023 NNP denotes R2
T9319 19023-19024 -RRB- denotes )
T9320 19025-19028 VBD denotes was
T9321 19029-19037 VBN denotes detected
T9322 19038-19040 IN denotes in
T9323 19041-19048 IN denotes between
T9324 19049-19054 DT denotes these
T9325 19055-19062 NNS denotes regions
T9326 19062-19063 , denotes ,
T9327 19064-19069 WDT denotes which
T9328 19070-19074 VBD denotes were
T9329 19075-19081 RB denotes highly
T9330 19082-19092 VBN denotes methylated
T9331 19093-19095 IN denotes in
T9332 19096-19110 JJ denotes IRF-4-negative
T9333 19111-19112 -LRB- denotes (
T9334 19112-19116 JJ denotes mean
T9335 19117-19123 NN denotes number
T9336 19124-19126 IN denotes of
T9337 19127-19137 JJ denotes methylated
T9338 19138-19144 NNS denotes clones
T9339 19145-19148 CD denotes 7.1
T9340 19149-19151 IN denotes of
T9341 19152-19153 CD denotes 8
T9342 19154-19158 IN denotes with
T9343 19159-19161 CD denotes 89
T9344 19161-19162 NN denotes %
T9345 19163-19173 VBD denotes methylated
T9346 19174-19178 NNS denotes CpGs
T9347 19178-19179 -RRB- denotes )
T9348 19180-19183 CC denotes but
T9349 19184-19191 RB denotes totally
T9350 19192-19206 JJ denotes non-methylated
T9351 19207-19209 IN denotes in
T9352 19210-19224 JJ denotes IRF-4-positive
T9353 19225-19230 NNS denotes cells
T9354 19231-19232 -LRB- denotes (
T9355 19232-19238 NN denotes Figure
T9356 19239-19241 CD denotes 4A
T9357 19242-19245 CC denotes and
T9358 19246-19247 NNP denotes B
T9359 19247-19248 -RRB- denotes )
T9360 19248-19249 . denotes .
T9361 19250-19261 RB denotes Furthermore
T9362 19261-19262 , denotes ,
T9363 19263-19268 CD denotes three
T9364 19269-19272 NNP denotes CpG
T9365 19273-19278 NNS denotes sites
T9366 19279-19281 IN denotes at
T9367 19282-19285 DT denotes the
T9368 19286-19287 CD denotes 5
T9369 19287-19288 NN denotes ′
T9370 19289-19292 NN denotes end
T9371 19293-19294 -LRB- denotes (
T9372 19294-19295 # denotes #
T9373 19295-19297 CD denotes 54
T9374 19297-19298 , denotes ,
T9375 19299-19301 CD denotes 56
T9376 19301-19302 , denotes ,
T9377 19303-19305 CD denotes 58
T9378 19305-19306 -RRB- denotes )
T9379 19307-19310 CC denotes and
T9380 19311-19314 CD denotes two
T9381 19315-19318 NNP denotes CpG
T9382 19319-19325 NNS denotes motifs
T9383 19326-19328 IN denotes at
T9384 19329-19332 DT denotes the
T9385 19333-19334 CD denotes 3
T9386 19334-19335 NN denotes ′
T9387 19336-19339 NN denotes end
T9388 19340-19341 -LRB- denotes (
T9389 19341-19342 # denotes #
T9390 19342-19343 CD denotes 1
T9391 19343-19344 , denotes ,
T9392 19345-19346 CD denotes 2
T9393 19346-19347 -RRB- denotes )
T9394 19348-19354 VBD denotes showed
T9395 19355-19359 DT denotes this
T9396 19360-19366 JJ denotes direct
T9397 19367-19378 NN denotes correlation
T9398 19379-19386 IN denotes between
T9399 19387-19391 JJ denotes high
T9400 19392-19403 NN denotes methylation
T9401 19404-19410 NN denotes status
T9402 19411-19414 CC denotes and
T9403 19415-19422 NN denotes absence
T9404 19423-19425 IN denotes of
T9405 19426-19431 NN denotes IRF-4
T9406 19432-19442 NN denotes expression
T9407 19442-19443 . denotes .
T9408 19444-19446 IN denotes In
T9409 19447-19455 NN denotes addition
T9410 19455-19456 , denotes ,
T9411 19457-19460 CD denotes two
T9412 19461-19464 NNP denotes CpG
T9413 19465-19470 NNS denotes sites
T9414 19471-19478 VBN denotes located
T9415 19479-19481 IN denotes in
T9416 19482-19483 DT denotes a
T9417 19484-19488 NNP denotes NFκB
T9418 19489-19490 -LRB- denotes (
T9419 19490-19491 # denotes #
T9420 19491-19493 CD denotes 48
T9421 19493-19494 -RRB- denotes )
T9422 19495-19498 CC denotes and
T9423 19499-19500 DT denotes a
T9424 19501-19504 NNP denotes SP1
T9425 19505-19512 NN denotes element
T9426 19513-19514 -LRB- denotes (
T9427 19514-19515 # denotes #
T9428 19515-19517 CD denotes 45
T9429 19517-19518 -RRB- denotes )
T9430 19519-19522 VBP denotes are
T9431 19523-19527 RBR denotes less
T9432 19528-19538 VBN denotes methylated
T9433 19539-19541 IN denotes in
T9434 19542-19556 JJ denotes IRF-4-positive
T9435 19557-19561 IN denotes than
T9436 19562-19564 IN denotes in
T9437 19565-19579 JJ denotes IRF-4-negative
T9438 19580-19585 NNS denotes cells
T9439 19586-19587 -LRB- denotes (
T9440 19587-19591 JJ denotes mean
T9441 19592-19598 NN denotes number
T9442 19599-19601 IN denotes of
T9443 19602-19612 JJ denotes methylated
T9444 19613-19619 NNS denotes clones
T9445 19619-19620 : denotes :
T9446 19621-19624 CD denotes 1/8
T9447 19625-19631 CC denotes versus
T9448 19632-19635 CD denotes 8/8
T9449 19635-19636 -RRB- denotes )
T9450 19636-19637 . denotes .
T9451 19638-19643 DT denotes These
T9452 19644-19651 NNS denotes results
T9453 19652-19660 VBP denotes indicate
T9454 19661-19664 DT denotes the
T9455 19665-19676 NN denotes involvement
T9456 19677-19679 IN denotes of
T9457 19680-19683 NNP denotes CpG
T9458 19684-19695 NN denotes methylation
T9459 19696-19698 IN denotes in
T9460 19699-19702 DT denotes the
T9461 19703-19713 NN denotes regulation
T9462 19714-19716 IN denotes of
T9463 19717-19722 NN denotes IRF-4
T9464 19723-19733 NN denotes expression
T9465 19734-19736 IN denotes in
T9466 19737-19745 JJ denotes leukemic
T9467 19746-19751 NNS denotes cells
T9468 19751-19752 . denotes .
T9878 19754-19756 IN denotes In
T9879 19757-19762 NN denotes vitro
T9880 19763-19774 NN denotes methylation
T9881 19775-19777 IN denotes of
T9882 19778-19780 DT denotes an
T9883 19781-19786 JJ denotes IRF-4
T9884 19787-19804 NN denotes promoter-reporter
T9885 19805-19814 VBP denotes construct
T9886 19815-19824 VBZ denotes decreases
T9887 19825-19828 PRP$ denotes its
T9888 19829-19837 NN denotes activity
T9889 19838-19840 TO denotes To
T9890 19841-19848 VB denotes provide
T9891 19849-19857 NN denotes evidence
T9892 19858-19861 IN denotes for
T9893 19862-19863 DT denotes a
T9894 19864-19870 JJ denotes direct
T9913 20001-20004 CC denotes and
T9914 20005-20010 IN denotes after
T9915 20011-20016 PRP$ denotes their
T9916 20017-20019 IN denotes in
T9917 20020-20025 NN denotes vitro
T9918 20026-20037 NN denotes methylation
T9919 20037-20038 . denotes .
T9920 20039-20040 DT denotes A
T9921 20041-20049 JJ denotes complete
T9922 20050-20061 NN denotes methylation
T9923 20062-20064 IN denotes of
T9924 20065-20070 DT denotes these
T9925 20071-20081 NNS denotes constructs
T9926 20082-20085 VBD denotes was
T9927 20086-20093 VBN denotes checked
T9928 20094-20097 IN denotes via
T9929 20098-20109 NN denotes restriction
T9930 20110-20116 NNS denotes assays
T9931 20117-20121 IN denotes with
T9932 20122-20143 JJ denotes methylation-sensitive
T9933 20144-20157 NNS denotes endonucleases
T9934 20158-20159 -LRB- denotes (
T9935 20159-20165 NN denotes Figure
T9936 20166-20168 NN denotes 5A
T9937 20168-20169 -RRB- denotes )
T9938 20169-20170 . denotes .
T9939 20171-20183 RB denotes Intriguingly
T9940 20183-20184 , denotes ,
T9941 20185-20196 NN denotes methylation
T9942 20197-20199 IN denotes of
T9943 20200-20203 DT denotes the
T9944 20204-20209 NN denotes IRF-4
T9945 20210-20218 NN denotes promoter
T9946 20219-20232 RB denotes significantly
T9947 20233-20242 VBD denotes decreased
T9948 20243-20251 NN denotes promoter
T9949 20252-20260 NN denotes activity
T9950 20261-20263 IN denotes in
T9951 20264-20278 JJ denotes IRF-4-positive
T9952 20279-20283 NN denotes SD-1
T9953 20284-20289 NNS denotes cells
T9954 20290-20292 IN denotes by
T9955 20293-20297 CD denotes 85.0
T9956 20297-20298 NN denotes %
T9957 20299-20300 -LRB- denotes (
T9958 20300-20306 NN denotes Figure
T9959 20307-20309 NN denotes 5B
T9960 20309-20310 -RRB- denotes )
T9961 20310-20311 . denotes .
T9962 20312-20315 DT denotes The
T9963 20316-20325 VBG denotes silencing
T9964 20326-20332 NN denotes effect
T9965 20333-20335 IN denotes of
T9966 20336-20339 NNP denotes CpG
T9967 20340-20351 NN denotes methylation
T9968 20352-20355 VBD denotes was
T9969 20356-20359 RB denotes not
T9970 20360-20370 VBN denotes restricted
T9971 20371-20373 TO denotes to
T9972 20374-20388 JJ denotes IRF-4-positive
T9973 20389-20394 NNS denotes cells
T9974 20394-20395 , denotes ,
T9975 20396-20401 IN denotes since
T9976 20402-20404 IN denotes in
T9977 20405-20410 NN denotes vitro
T9978 20411-20422 NN denotes methylation
T9979 20423-20426 VBD denotes led
T9980 20427-20429 TO denotes to
T9981 20430-20431 DT denotes a
T9982 20432-20436 CD denotes 92.9
T9983 20436-20437 NN denotes %
T9984 20438-20448 NN denotes abrogation
T9985 20449-20451 IN denotes of
T9986 20452-20460 NN denotes promoter
T9987 20461-20469 NN denotes activity
T9988 20470-20472 IN denotes in
T9989 20473-20487 JJ denotes IRF-4-negative
T9990 20488-20494 NNP denotes Jurkat
T9991 20495-20500 NNS denotes cells
T9992 20501-20502 -LRB- denotes (
T9993 20502-20508 NN denotes Figure
T9994 20509-20511 NN denotes 5C
T9995 20511-20512 -RRB- denotes )
T9996 20512-20513 . denotes .
T9997 20514-20516 IN denotes In
T9998 20517-20525 NN denotes contrast
T9999 20525-20526 , denotes ,
T10000 20527-20534 NN denotes control
T10001 20535-20546 NN denotes methylation
T10002 20547-20549 IN denotes of
T10003 20550-20551 DT denotes a
T10004 20552-20560 NN denotes reporter
T10005 20561-20570 VBP denotes construct
T10006 20571-20575 IN denotes with
T10007 20576-20577 DT denotes a
T10008 20578-20587 JJ denotes different
T10009 20588-20596 NN denotes promoter
T10010 20597-20598 -LRB- denotes (
T10011 20598-20602 NNP denotes FasL
T10012 20602-20603 -RRB- denotes )
T10013 20604-20606 RB denotes as
T10014 20607-20611 RB denotes well
T10015 20612-20614 IN denotes as
T10016 20615-20617 DT denotes an
T10017 20618-20623 JJ denotes empty
T10018 20624-20630 NN denotes vector
T10019 20631-20634 VBD denotes had
T10020 20635-20637 DT denotes no
T10021 20638-20644 NN denotes effect
T10022 20645-20647 IN denotes on
T10023 20648-20651 DT denotes the
T10024 20652-20660 NN denotes reporter
T10025 20661-20669 NN denotes activity
T10026 20670-20671 -LRB- denotes (
T10027 20671-20675 NNS denotes data
T10028 20676-20679 RB denotes not
T10029 20680-20685 VBN denotes shown
T10030 20685-20686 -RRB- denotes )
T10031 20686-20687 . denotes .
T10032 20688-20693 DT denotes These
T10033 20694-20698 NNS denotes data
T10034 20699-20705 VBD denotes proved
T10035 20706-20707 DT denotes a
T10036 20708-20714 JJ denotes direct
T10037 20715-20726 NN denotes association
T10038 20727-20734 IN denotes between
T10039 20735-20746 NN denotes methylation
T10040 20747-20750 CC denotes and
T10041 20751-20759 NN denotes activity
T10042 20760-20762 IN denotes of
T10043 20763-20766 DT denotes the
T10044 20767-20772 NN denotes IRF-4
T10045 20773-20781 NN denotes promoter
T10046 20781-20782 . denotes .
T10434 20784-20788 NNP denotes mRNA
T10435 20789-20799 NN denotes expression
T10436 20800-20802 IN denotes of
T10437 20803-20806 NNP denotes DNA
T10438 20807-20825 NNS denotes methyltransferases
T10439 20826-20829 CC denotes and
T10440 20830-20848 JJ denotes methyl-CpG-binding
T10441 20849-20857 NNS denotes proteins
T10442 20858-20861 MD denotes may
T10443 20862-20865 RB denotes not
T10444 20866-20868 VB denotes be
T10445 20869-20879 VBN denotes associated
T10446 20880-20884 IN denotes with
T10447 20885-20890 JJ denotes IRF-4
T10448 20891-20899 NN denotes promoter
T10449 20900-20911 NN denotes methylation
T10450 20912-20917 IN denotes Since
T10451 20918-20927 NN denotes abundance
T10452 20928-20930 IN denotes of
T10453 20931-20935 NNP denotes DNMT
T10454 20936-20939 CC denotes and
T10455 20940-20943 NNP denotes MBP
T10456 20944-20954 VBP denotes contribute
T10457 20955-20957 TO denotes to
T10458 20958-20966 NN denotes promoter
T10459 20967-20977 NN denotes regulation
T10460 20978-20981 IN denotes via
T10461 20982-20993 NN denotes methylation
T10462 20994-20995 -LRB- denotes (
T10463 20995-21003 CD denotes 25,26,28
T10464 21003-21004 -RRB- denotes )
T10465 21004-21005 , denotes ,
T10466 21006-21008 PRP denotes we
T10467 21009-21016 VBD denotes studied
T10468 21017-21022 PRP$ denotes their
T10469 21023-21027 NNP denotes mRNA
T10470 21028-21038 NN denotes expression
T10471 21039-21041 TO denotes to
T10472 21042-21053 VB denotes investigate
T10473 21054-21055 DT denotes a
T10474 21056-21064 JJ denotes possible
T10475 21065-21074 NN denotes mechanism
T10476 21075-21078 IN denotes for
T10477 21079-21082 DT denotes the
T10478 21083-21091 JJ denotes observed
T10479 21092-21103 NN denotes methylation
T10480 21104-21115 NNS denotes differences
T10481 21116-21118 IN denotes in
T10482 21119-21122 DT denotes the
T10483 21123-21128 NN denotes IRF-4
T10484 21129-21137 NN denotes promoter
T10485 21137-21138 . denotes .
T10486 21139-21141 TO denotes To
T10487 21142-21146 DT denotes this
T10488 21147-21150 NN denotes end
T10489 21150-21151 , denotes ,
T10490 21152-21154 PRP denotes we
T10491 21155-21158 VBD denotes did
T10492 21159-21162 RB denotes not
T10493 21163-21169 VB denotes detect
T10494 21170-21171 DT denotes a
T10495 21172-21183 JJ denotes significant
T10496 21184-21194 NN denotes difference
T10497 21195-21197 IN denotes in
T10498 21198-21202 NNP denotes DNMT
T10499 21203-21204 -LRB- denotes (
T10500 21204-21209 NNP denotes DNMT1
T10501 21209-21210 , denotes ,
T10502 21211-21217 NNP denotes DNMT3A
T10503 21218-21221 CC denotes and
T10504 21222-21228 NNP denotes DNMT3B
T10505 21228-21229 -RRB- denotes )
T10506 21230-21232 CC denotes or
T10507 21233-21236 NNP denotes MBP
T10508 21237-21238 -LRB- denotes (
T10509 21238-21242 NNP denotes MBD1
T10510 21242-21243 , denotes ,
T10511 21244-21248 NNP denotes MBD2
T10512 21248-21249 , denotes ,
T10513 21250-21254 NNP denotes MBD4
T10514 21255-21258 CC denotes and
T10515 21259-21263 NNP denotes MeCP
T10516 21263-21264 -RRB- denotes )
T10517 21265-21269 NNP denotes mRNA
T10518 21270-21280 NN denotes expression
T10519 21281-21288 IN denotes between
T10520 21289-21303 JJ denotes IRF-4-positive
T10521 21304-21307 CC denotes and
T10522 21308-21309 : denotes -
T10523 21309-21317 JJ denotes negative
T10524 21318-21323 NNS denotes cells
T10525 21324-21325 -LRB- denotes (
T10526 21325-21331 NN denotes Figure
T10527 21332-21334 CD denotes 5D
T10528 21334-21335 -RRB- denotes )
T10529 21335-21336 . denotes .
T10530 21337-21339 IN denotes In
T10531 21340-21344 NN denotes fact
T10532 21344-21345 , denotes ,
T10533 21346-21349 DT denotes all
T10534 21350-21358 VBD denotes analyzed
T10535 21359-21364 NNS denotes cells
T10536 21365-21368 VBD denotes had
T10537 21369-21377 JJ denotes moderate
T10538 21378-21380 TO denotes to
T10539 21381-21385 JJ denotes high
T10540 21386-21390 NN denotes mRNA
T10541 21391-21397 NNS denotes levels
T10542 21398-21400 IN denotes of
T10543 21401-21406 DT denotes these
T10544 21407-21413 VBN denotes tested
T10545 21414-21423 NNP denotes DNMT/MBPs
T10546 21424-21427 CC denotes and
T10547 21428-21439 NNS denotes differences
T10548 21440-21442 IN denotes in
T10549 21443-21453 NN denotes expression
T10550 21454-21458 VBD denotes were
T10551 21459-21462 RB denotes not
T10552 21463-21473 VBN denotes correlated
T10553 21474-21478 IN denotes with
T10554 21479-21484 JJ denotes IRF-4
T10555 21485-21491 NN denotes status
T10556 21491-21492 . denotes .
T10557 21493-21498 DT denotes These
T10558 21499-21506 NNS denotes results
T10559 21507-21515 VBP denotes indicate
T10560 21516-21517 DT denotes a
T10561 21518-21526 JJ denotes distinct
T10562 21527-21532 NN denotes cause
T10563 21533-21535 IN denotes of
T10564 21536-21539 DT denotes the
T10565 21540-21551 NN denotes methylation
T10566 21552-21563 NNS denotes differences
T10567 21564-21566 IN denotes in
T10568 21567-21581 JJ denotes IRF-4-positive
T10569 21582-21585 CC denotes and
T10570 21586-21587 : denotes -
T10571 21587-21595 JJ denotes negative
T10572 21596-21601 NNS denotes cells
T10573 21602-21608 RB denotes rather
T10574 21609-21613 IN denotes than
T10575 21614-21621 NNS denotes changes
T10576 21622-21624 IN denotes in
T10577 21625-21628 DT denotes the
T10578 21629-21633 NNP denotes DNMT
T10579 21634-21637 CC denotes and
T10580 21638-21641 NNP denotes MBP
T10581 21642-21646 NNP denotes mRNA
T10582 21647-21660 NN denotes transcription
T10583 21660-21661 . denotes .
T12531 21674-21678 JJ denotes Many
T12532 21679-21686 JJ denotes genetic
T12533 21687-21694 NNS denotes lesions
T12534 21695-21698 VBP denotes are
T12535 21699-21704 VBN denotes known
T12536 21705-21707 TO denotes to
T12537 21708-21717 VB denotes influence
T12538 21718-21722 NN denotes gene
T12539 21723-21733 NN denotes expression
T12540 21734-21736 IN denotes of
T12541 21737-21742 NN denotes tumor
T12542 21743-21753 NN denotes suppressor
T12543 21754-21759 NNS denotes genes
T12544 21759-21760 . denotes .
T12545 21761-21768 IN denotes Whereas
T12546 21769-21778 NNS denotes mutations
T12547 21779-21782 CC denotes and
T12548 21783-21792 NNS denotes deletions
T12549 21793-21795 CC denotes or
T12550 21796-21806 NNS denotes insertions
T12551 21807-21811 VBP denotes have
T12552 21812-21821 JJ denotes permanent
T12553 21822-21829 NNS denotes effects
T12554 21829-21830 , denotes ,
T12555 21831-21841 JJ denotes reversible
T12556 21842-21852 NNS denotes mechanisms
T12557 21853-21856 VBP denotes are
T12558 21857-21861 NN denotes gene
T12559 21862-21873 NN denotes methylation
T12560 21873-21874 , denotes ,
T12561 21875-21877 CC denotes or
T12562 21878-21888 NN denotes expression
T12563 21889-21892 CC denotes and
T12564 21893-21903 NN denotes activation
T12565 21904-21906 IN denotes of
T12566 21907-21920 NN denotes transcription
T12567 21921-21928 NNS denotes factors
T12568 21928-21929 , denotes ,
T12569 21930-21942 RB denotes respectively
T12570 21942-21943 . denotes .
T12571 21944-21946 PRP denotes We
T12572 21947-21954 VBD denotes studied
T12573 21955-21956 DT denotes a
T12574 21957-21965 JJ denotes putative
T12575 21966-21971 NN denotes cause
T12576 21972-21975 IN denotes for
T12577 21976-21982 JJ denotes absent
T12578 21983-21988 NN denotes IRF-4
T12579 21989-21999 NN denotes expression
T12580 22000-22002 IN denotes in
T12581 22003-22011 NN denotes leukemia
T12582 22012-22017 NNS denotes cells
T12583 22018-22021 CC denotes and
T12584 22022-22027 JJ denotes first
T12585 22028-22035 VBN denotes focused
T12586 22036-22038 IN denotes on
T12587 22039-22046 JJ denotes genetic
T12588 22047-22058 NNS denotes aberrations
T12589 22059-22061 IN denotes of
T12590 22062-22065 DT denotes the
T12591 22066-22074 NN denotes promoter
T12592 22074-22075 . denotes .
T12593 22076-22078 PRP denotes We
T12594 22079-22087 VBD denotes observed
T12595 22088-22090 DT denotes no
T12596 22091-22098 JJ denotes genetic
T12597 22099-22110 NNS denotes alterations
T12598 22111-22113 IN denotes in
T12599 22114-22117 DT denotes the
T12600 22118-22123 NN denotes IRF-4
T12601 22124-22132 NN denotes promoter
T12602 22132-22133 , denotes ,
T12603 22134-22139 WDT denotes which
T12604 22140-22143 MD denotes can
T12605 22144-22151 VB denotes account
T12606 22152-22155 IN denotes for
T12607 22156-22159 DT denotes the
T12608 22160-22164 NN denotes lack
T12609 22165-22167 IN denotes of
T12610 22168-22173 NN denotes IRF-4
T12611 22174-22184 NN denotes expression
T12612 22184-22185 : denotes :
T12613 22186-22189 DT denotes The
T12614 22190-22198 VBN denotes detected
T12615 22199-22203 NN denotes base
T12616 22204-22208 NN denotes pair
T12617 22209-22216 NNS denotes changes
T12618 22217-22219 IN denotes at
T12619 22220-22228 NN denotes position
T12620 22229-22230 NN denotes −
T12621 22230-22234 CD denotes 1081
T12622 22235-22236 -LRB- denotes (
T12623 22236-22237 NNP denotes T
T12624 22237-22238 CD denotes →
T12625 22238-22239 NNP denotes C
T12626 22240-22252 NN denotes substitution
T12627 22252-22253 -RRB- denotes )
T12628 22253-22254 , denotes ,
T12629 22255-22257 IN denotes at
T12630 22258-22266 NN denotes position
T12631 22267-22268 NN denotes −
T12632 22268-22272 CD denotes 1068
T12633 22273-22274 -LRB- denotes (
T12634 22274-22275 DT denotes A
T12635 22275-22276 NN denotes →
T12636 22276-22277 NNP denotes C
T12637 22278-22290 NN denotes substitution
T12638 22290-22291 -RRB- denotes )
T12639 22292-22295 CC denotes and
T12640 22296-22298 IN denotes at
T12641 22299-22307 NN denotes position
T12642 22308-22309 NN denotes −
T12643 22309-22312 CD denotes 116
T12644 22313-22314 -LRB- denotes (
T12645 22314-22315 DT denotes A
T12646 22315-22316 NN denotes →
T12647 22316-22317 NNP denotes C
T12648 22318-22330 NN denotes substitution
T12649 22330-22331 -RRB- denotes )
T12650 22332-22335 VBP denotes are
T12651 22336-22344 JJ denotes unlikely
T12652 22345-22356 JJ denotes responsible
T12653 22357-22360 IN denotes for
T12654 22361-22367 JJ denotes absent
T12655 22368-22384 NN denotes IRF-4-expression
T12656 22385-22390 IN denotes since
T12657 22391-22394 DT denotes the
T12658 22395-22400 JJ denotes first
T12659 22401-22404 CD denotes two
T12660 22405-22414 NNS denotes mutations
T12661 22415-22419 VBD denotes were
T12662 22420-22425 VBN denotes found
T12663 22426-22430 DT denotes both
T12664 22431-22433 IN denotes in
T12665 22434-22448 JJ denotes IRF-4-positive
T12666 22449-22452 CC denotes and
T12667 22453-22454 : denotes -
T12668 22454-22462 JJ denotes negative
T12669 22463-22468 NNS denotes cells
T12670 22469-22476 IN denotes whereas
T12671 22477-22480 DT denotes the
T12672 22481-22487 JJ denotes latter
T12673 22488-22494 NN denotes change
T12674 22495-22498 VBD denotes was
T12675 22499-22502 RB denotes not
T12676 22503-22511 VBN denotes detected
T12677 22512-22524 RB denotes consistently
T12678 22525-22527 IN denotes in
T12679 22528-22531 DT denotes all
T12680 22532-22546 JJ denotes IRF-4-negative
T12681 22547-22549 CC denotes or
T12682 22550-22551 : denotes -
T12683 22551-22559 JJ denotes positive
T12684 22560-22565 NNS denotes cells
T12685 22566-22569 CC denotes and
T12686 22570-22573 MD denotes may
T12687 22574-22578 RB denotes thus
T12688 22579-22581 VB denotes be
T12689 22582-22583 DT denotes a
T12690 22584-22596 NN denotes polymorphism
T12691 22596-22597 . denotes .
T12692 22598-22601 DT denotes All
T12693 22602-22607 CD denotes three
T12694 22608-22621 NNS denotes substitutions
T12695 22622-22625 VBD denotes did
T12696 22626-22629 RB denotes not
T12697 22630-22636 VB denotes change
T12698 22637-22640 DT denotes any
T12699 22641-22646 JJ denotes known
T12700 22647-22655 JJ denotes putative
T12701 22656-22669 NN denotes transcription
T12702 22670-22676 NN denotes factor
T12703 22677-22684 JJ denotes binding
T12704 22685-22690 NNS denotes sites
T12705 22691-22692 -LRB- denotes (
T12706 22692-22697 CD denotes 30,31
T12707 22697-22698 -RRB- denotes )
T12708 22699-22702 CC denotes and
T12709 22703-22707 RB denotes also
T12710 22708-22710 VBP denotes do
T12711 22711-22714 RB denotes not
T12712 22715-22721 VB denotes affect
T12713 22722-22725 DT denotes any
T12714 22726-22737 NN denotes restriction
T12715 22738-22743 NNS denotes sites
T12716 22744-22746 CC denotes or
T12717 22747-22753 JJR denotes primer
T12718 22754-22761 JJ denotes binding
T12719 22762-22767 NNS denotes sites
T12720 22768-22770 IN denotes of
T12721 22771-22774 DT denotes the
T12722 22775-22779 VBN denotes used
T12723 22780-22786 NNS denotes assays
T12724 22786-22787 . denotes .
T12725 22788-22795 RB denotes However
T12726 22795-22796 , denotes ,
T12727 22797-22806 JJ denotes permanent
T12728 22807-22814 JJ denotes genetic
T12729 22815-22825 NNS denotes variations
T12730 22826-22828 IN denotes in
T12731 22829-22832 DT denotes the
T12732 22833-22838 NN denotes IRF-4
T12733 22839-22845 VBG denotes coding
T12734 22846-22854 NN denotes sequence
T12735 22854-22855 , denotes ,
T12736 22856-22860 JJ denotes such
T12737 22861-22863 IN denotes as
T12738 22864-22873 NNS denotes deletions
T12739 22874-22876 CC denotes or
T12740 22877-22886 NNS denotes mutations
T12741 22887-22896 VBG denotes resulting
T12742 22897-22899 IN denotes in
T12743 22900-22911 NNS denotes stop-codons
T12744 22912-22916 VBP denotes have
T12745 22917-22920 RB denotes not
T12746 22921-22925 VBN denotes been
T12747 22926-22934 VBN denotes excluded
T12748 22935-22937 IN denotes by
T12749 22938-22946 NN denotes sequence
T12750 22947-22955 NN denotes analysis
T12751 22955-22956 . denotes .
T12752 22957-22962 IN denotes Since
T12753 22963-22968 NNP denotes IRF-4
T12754 22969-22979 NN denotes expression
T12755 22980-22982 IN denotes in
T12756 22983-22987 NN denotes cell
T12757 22988-22993 NNS denotes lines
T12758 22994-22997 CC denotes and
T12759 22998-23001 NNP denotes CML
T12760 23002-23005 MD denotes can
T12761 23006-23008 VB denotes be
T12762 23009-23016 VBN denotes induced
T12763 23017-23019 IN denotes by
T12764 23020-23033 NN denotes demethylation
T12765 23034-23037 CC denotes and
T12766 23038-23048 JJ denotes successful
T12767 23049-23054 JJ denotes IFN-α
T12768 23055-23062 NN denotes therapy
T12769 23063-23064 -LRB- denotes (
T12770 23064-23065 LS denotes 3
T12771 23065-23066 -RRB- denotes )
T12772 23066-23067 , denotes ,
T12773 23068-23080 RB denotes respectively
T12774 23080-23081 , denotes ,
T12775 23082-23085 DT denotes the
T12776 23086-23095 NN denotes existence
T12777 23096-23098 IN denotes of
T12778 23099-23103 JJ denotes such
T12779 23104-23111 JJ denotes genetic
T12780 23112-23123 NNS denotes aberrations
T12781 23124-23129 VBZ denotes seems
T12782 23130-23138 JJ denotes unlikely
T12783 23138-23139 . denotes .
T12784 23140-23142 PRP denotes We
T12785 23143-23147 RB denotes then
T12786 23148-23160 VBD denotes investigated
T12787 23161-23168 IN denotes whether
T12788 23169-23172 DT denotes the
T12789 23173-23183 RB denotes previously
T12790 23184-23193 VBN denotes described
T12791 23194-23209 NN denotes down-regulation
T12792 23210-23212 IN denotes of
T12793 23213-23218 NN denotes IRF-4
T12794 23219-23229 NN denotes expression
T12795 23230-23232 IN denotes in
T12796 23233-23238 JJ denotes human
T12797 23239-23246 JJ denotes myeloid
T12798 23247-23256 NNS denotes leukemias
T12799 23257-23260 VBD denotes was
T12800 23261-23264 JJ denotes due
T12801 23265-23267 TO denotes to
T12802 23268-23269 DT denotes a
T12803 23270-23282 JJ denotes differential
T12804 23283-23299 NN denotes hypermethylation
T12805 23300-23302 IN denotes of
T12806 23303-23306 DT denotes the
T12807 23307-23315 NN denotes promoter
T12808 23315-23316 , denotes ,
T12809 23317-23322 IN denotes since
T12810 23323-23326 DT denotes the
T12811 23327-23336 VBN denotes presented
T12812 23337-23350 NN denotes re-expression
T12813 23351-23354 JJ denotes due
T12814 23355-23357 TO denotes to
T12815 23358-23373 NNP denotes AzadC-treatment
T12816 23374-23379 MD denotes might
T12817 23380-23384 RB denotes also
T12818 23385-23387 VB denotes be
T12819 23388-23389 DT denotes a
T12820 23390-23396 NN denotes result
T12821 23397-23399 IN denotes of
T12822 23400-23410 NN denotes activation
T12823 23411-23413 IN denotes of
T12824 23414-23422 JJ denotes positive
T12825 23423-23438 JJ denotes transcriptional
T12826 23439-23449 NNS denotes regulators
T12827 23450-23452 IN denotes of
T12828 23453-23458 NN denotes IRF-4
T12829 23458-23459 . denotes .
T12830 23460-23471 NNP denotes Methylation
T12831 23472-23474 IN denotes of
T12832 23475-23478 NNP denotes CpG
T12833 23479-23484 NNS denotes sites
T12834 23485-23487 VBZ denotes is
T12835 23488-23489 DT denotes a
T12836 23490-23496 JJ denotes common
T12837 23497-23506 NN denotes mechanism
T12838 23507-23509 IN denotes of
T12839 23510-23519 VBG denotes silencing
T12840 23520-23525 NNS denotes genes
T12841 23526-23528 IN denotes in
T12842 23529-23537 NN denotes leukemia
T12843 23538-23541 CC denotes and
T12844 23542-23545 VBZ denotes has
T12845 23546-23550 RB denotes also
T12846 23551-23555 VBN denotes been
T12847 23556-23561 VBN denotes shown
T12848 23562-23565 IN denotes for
T12849 23566-23573 DT denotes another
T12850 23574-23577 NNP denotes IRF
T12851 23577-23578 , denotes ,
T12852 23579-23584 NNP denotes IRF-7
T12853 23585-23586 -LRB- denotes (
T12854 23586-23588 CD denotes 35
T12855 23588-23589 -RRB- denotes )
T12856 23590-23593 CC denotes and
T12857 23594-23597 IN denotes for
T12858 23598-23600 NNP denotes PU
T12859 23600-23602 CD denotes .1
T12860 23603-23604 -LRB- denotes (
T12861 23604-23606 CD denotes 36
T12862 23606-23607 -RRB- denotes )
T12863 23607-23608 , denotes ,
T12864 23609-23611 DT denotes an
T12865 23612-23623 VBG denotes interacting
T12866 23624-23631 NN denotes partner
T12867 23632-23634 IN denotes of
T12868 23635-23640 NN denotes IRF-4
T12869 23640-23641 . denotes .
T12870 23642-23644 TO denotes To
T12871 23645-23654 VB denotes elucidate
T12872 23655-23658 DT denotes the
T12873 23659-23668 NN denotes relevance
T12874 23669-23671 IN denotes of
T12875 23672-23676 DT denotes this
T12876 23677-23686 NN denotes mechanism
T12877 23687-23690 IN denotes for
T12878 23691-23694 DT denotes the
T12879 23695-23705 NN denotes regulation
T12880 23706-23708 IN denotes of
T12881 23709-23714 NN denotes IRF-4
T12882 23715-23725 NN denotes expression
T12883 23725-23726 , denotes ,
T12884 23727-23734 JJ denotes various
T12885 23735-23743 JJ denotes leukemic
T12886 23744-23749 NNS denotes cells
T12887 23750-23754 VBD denotes were
T12888 23755-23762 VBN denotes treated
T12889 23763-23767 IN denotes with
T12890 23768-23781 VBG denotes demethylating
T12891 23782-23788 NNS denotes agents
T12892 23789-23792 CC denotes and
T12893 23793-23802 NNS denotes promoters
T12894 23803-23807 VBD denotes were
T12895 23808-23817 VBN denotes sequenced
T12896 23818-23823 IN denotes after
T12897 23824-23833 JJ denotes bisulfite
T12898 23834-23843 NN denotes treatment
T12899 23843-23844 . denotes .
T12900 23845-23847 PRP denotes We
T12901 23848-23853 VBD denotes found
T12902 23854-23858 IN denotes that
T12903 23859-23864 JJ denotes IRF-4
T12904 23865-23875 NN denotes expression
T12905 23876-23881 MD denotes could
T12906 23882-23888 RB denotes indeed
T12907 23889-23891 VB denotes be
T12908 23892-23901 VBN denotes connected
T12909 23902-23904 TO denotes to
T12910 23905-23908 DT denotes the
T12911 23909-23920 NN denotes methylation
T12912 23921-23927 NN denotes status
T12913 23928-23930 IN denotes of
T12914 23931-23939 JJ denotes distinct
T12915 23940-23943 NNP denotes CpG
T12916 23944-23950 NNS denotes motifs
T12917 23951-23953 IN denotes in
T12918 23954-23957 DT denotes the
T12919 23958-23963 NN denotes IRF-4
T12920 23964-23972 NN denotes promoter
T12921 23972-23973 . denotes .
T12922 23974-23976 IN denotes In
T12923 23977-23983 NNP denotes Figure
T12924 23984-23986 NNP denotes 4A
T12925 23986-23987 , denotes ,
T12926 23988-23993 DT denotes those
T12927 23994-23997 NNP denotes CpG
T12928 23998-24003 NNS denotes sites
T12929 24004-24007 VBP denotes are
T12930 24008-24013 VBN denotes shown
T12931 24014-24015 -LRB- denotes (
T12932 24015-24021 JJ denotes bottom
T12933 24022-24026 NN denotes line
T12934 24026-24027 -RRB- denotes )
T12935 24027-24028 , denotes ,
T12936 24029-24034 WP$ denotes whose
T12937 24035-24051 NN denotes hypermethylation
T12938 24052-24055 MD denotes may
T12939 24056-24063 VB denotes account
T12940 24064-24067 IN denotes for
T12941 24068-24071 DT denotes the
T12942 24072-24079 NN denotes absence
T12943 24080-24082 IN denotes of
T12944 24083-24088 NN denotes IRF-4
T12945 24089-24099 NN denotes expression
T12946 24100-24102 IN denotes in
T12947 24103-24106 DT denotes the
T12948 24107-24117 JJ denotes respective
T12949 24118-24123 NNS denotes cells
T12950 24123-24124 . denotes .
T12951 24125-24128 CD denotes One
T12952 24129-24131 IN denotes of
T12953 24132-24136 PRP denotes them
T12954 24137-24138 -LRB- denotes (
T12955 24138-24139 # denotes #
T12956 24139-24141 CD denotes 54
T12957 24141-24142 -RRB- denotes )
T12958 24143-24145 VBZ denotes is
T12959 24146-24154 JJ denotes adjacent
T12960 24155-24157 TO denotes to
T12961 24158-24160 DT denotes an
T12962 24161-24171 VBN denotes identified
T12963 24172-24182 JJ denotes regulatory
T12964 24183-24190 NN denotes element
T12965 24191-24192 -LRB- denotes (
T12966 24192-24201 JJ denotes NFκB-site
T12967 24201-24202 -RRB- denotes )
T12968 24202-24203 , denotes ,
T12969 24204-24214 VBG denotes indicating
T12970 24215-24216 DT denotes a
T12971 24217-24225 JJ denotes possible
T12972 24226-24237 NN denotes involvement
T12973 24238-24240 IN denotes of
T12974 24241-24245 DT denotes this
T12975 24246-24250 NN denotes site
T12976 24250-24251 . denotes .
T12977 24252-24254 IN denotes At
T12978 24255-24258 CD denotes two
T12979 24259-24266 JJ denotes further
T12980 24267-24270 NNP denotes CpG
T12981 24271-24276 NNS denotes sites
T12982 24277-24278 -LRB- denotes (
T12983 24278-24279 # denotes #
T12984 24279-24281 CD denotes 48
T12985 24281-24282 , denotes ,
T12986 24283-24285 CD denotes 45
T12987 24285-24286 -RRB- denotes )
T12988 24287-24290 DT denotes the
T12989 24291-24302 NN denotes methylation
T12990 24303-24309 NN denotes status
T12991 24310-24312 IN denotes in
T12992 24313-24327 JJ denotes IRF-4-positive
T12993 24328-24331 VBD denotes was
T12994 24332-24337 JJR denotes lower
T12995 24338-24342 IN denotes than
T12996 24343-24347 DT denotes that
T12997 24348-24350 IN denotes of
T12998 24351-24365 JJ denotes IRF-4-negative
T12999 24366-24371 NNS denotes cells
T13000 24371-24372 . denotes .
T13001 24373-24378 DT denotes These
T13002 24379-24382 NNP denotes CpG
T13003 24383-24388 NNS denotes sites
T13004 24389-24392 VBP denotes are
T13005 24393-24400 VBN denotes located
T13006 24401-24403 IN denotes in
T13007 24404-24406 DT denotes an
T13008 24407-24411 NNP denotes NFκB
T13009 24412-24415 CC denotes and
T13010 24416-24418 DT denotes an
T13011 24419-24422 CD denotes SP1
T13012 24423-24430 NN denotes element
T13013 24431-24432 -LRB- denotes (
T13014 24432-24434 CD denotes 31
T13015 24434-24435 -RRB- denotes )
T13016 24436-24439 CC denotes and
T13017 24440-24444 RB denotes thus
T13018 24445-24448 MD denotes may
T13019 24449-24453 RB denotes also
T13020 24454-24458 VB denotes play
T13021 24459-24460 DT denotes a
T13022 24461-24465 NN denotes role
T13023 24466-24468 IN denotes in
T13024 24469-24479 NN denotes regulation
T13025 24480-24482 IN denotes of
T13026 24483-24488 NN denotes IRF-4
T13027 24489-24499 NN denotes expression
T13028 24499-24500 . denotes .
T13029 24501-24503 PRP denotes It
T13030 24504-24507 VBZ denotes has
T13031 24508-24512 VBN denotes been
T13032 24513-24518 VBN denotes shown
T13033 24519-24523 IN denotes that
T13034 24524-24528 NNP denotes NFκB
T13035 24529-24537 NNS denotes elements
T13036 24538-24542 VBP denotes play
T13037 24543-24545 DT denotes an
T13038 24546-24555 JJ denotes important
T13039 24556-24560 NN denotes role
T13040 24561-24563 IN denotes in
T13041 24564-24569 NN denotes IRF-4
T13042 24570-24579 NN denotes induction
T13043 24580-24582 IN denotes as
T13044 24583-24588 JJ denotes IRF-4
T13045 24589-24599 NN denotes expression
T13046 24600-24607 VBZ denotes depends
T13047 24608-24610 IN denotes on
T13048 24611-24618 JJ denotes binding
T13049 24619-24621 IN denotes of
T13050 24622-24625 DT denotes the
T13051 24626-24640 NN denotes transactivator
T13052 24641-24646 NN denotes c-Rel
T13053 24647-24649 TO denotes to
T13054 24650-24655 DT denotes these
T13055 24656-24664 NNS denotes elements
T13056 24665-24667 IN denotes in
T13057 24668-24671 DT denotes the
T13058 24672-24677 NN denotes IRF-4
T13059 24678-24686 NN denotes promoter
T13060 24687-24688 -LRB- denotes (
T13061 24688-24693 CD denotes 31,37
T13062 24693-24694 -RRB- denotes )
T13063 24694-24695 . denotes .
T13064 24696-24707 RB denotes Furthermore
T13065 24707-24708 , denotes ,
T13066 24709-24720 NN denotes methylation
T13067 24721-24723 IN denotes of
T13068 24724-24727 DT denotes the
T13069 24728-24735 JJ denotes central
T13070 24736-24739 NNP denotes CpG
T13071 24740-24742 IN denotes in
T13072 24743-24746 DT denotes the
T13073 24747-24751 NNP denotes NFκB
T13074 24752-24759 NN denotes element
T13075 24760-24768 VBZ denotes inhibits
T13076 24769-24776 JJ denotes binding
T13077 24777-24779 IN denotes of
T13078 24780-24783 DT denotes the
T13079 24784-24788 NNP denotes NFκB
T13080 24789-24796 NN denotes protein
T13081 24797-24806 NNS denotes complexes
T13082 24807-24808 -LRB- denotes (
T13083 24808-24810 CD denotes 38
T13084 24810-24811 -RRB- denotes )
T13085 24811-24812 , denotes ,
T13086 24813-24822 VBG denotes promoting
T13087 24823-24826 DT denotes the
T13088 24827-24839 NN denotes significance
T13089 24840-24842 IN denotes of
T13090 24843-24846 DT denotes the
T13091 24847-24855 JJ denotes observed
T13092 24856-24867 NN denotes methylation
T13093 24868-24879 NNS denotes differences
T13094 24880-24882 IN denotes in
T13095 24883-24897 JJ denotes IRF-4-positive
T13096 24898-24901 CC denotes and
T13097 24902-24903 : denotes -
T13098 24903-24911 JJ denotes negative
T13099 24912-24917 NNS denotes cells
T13100 24917-24918 . denotes .
T13101 24919-24922 NNP denotes Via
T13102 24923-24925 IN denotes in
T13103 24926-24931 NN denotes vitro
T13104 24932-24943 NN denotes methylation
T13105 24944-24947 CC denotes and
T13106 24948-24956 NN denotes reporter
T13107 24957-24961 NN denotes gene
T13108 24962-24968 IN denotes assays
T13109 24969-24971 PRP denotes we
T13110 24972-24977 MD denotes could
T13111 24978-24985 RB denotes clearly
T13112 24986-24993 VB denotes appoint
T13113 24994-24997 DT denotes the
T13114 24998-25007 NN denotes silencing
T13115 25008-25010 IN denotes of
T13116 25011-25014 DT denotes the
T13117 25015-25020 NN denotes IRF-4
T13118 25021-25029 NN denotes promoter
T13119 25030-25032 TO denotes to
T13120 25033-25034 DT denotes a
T13121 25035-25046 NN denotes methylation
T13122 25047-25053 NN denotes effect
T13123 25053-25054 , denotes ,
T13124 25055-25060 WDT denotes which
T13125 25061-25064 MD denotes may
T13126 25065-25069 RB denotes thus
T13127 25070-25072 VB denotes be
T13128 25073-25076 DT denotes the
T13129 25077-25086 NN denotes mechanism
T13130 25087-25089 IN denotes of
T13131 25090-25095 NN denotes IRF-4
T13132 25096-25108 NN denotes deregulation
T13133 25109-25111 IN denotes in
T13134 25112-25116 NN denotes vivo
T13135 25116-25117 . denotes .
T13136 25118-25121 CD denotes One
T13137 25122-25130 JJ denotes possible
T13138 25131-25136 NN denotes cause
T13139 25137-25140 IN denotes for
T13140 25141-25144 DT denotes the
T13141 25145-25153 JJ denotes aberrant
T13142 25154-25165 NN denotes methylation
T13143 25166-25168 IN denotes in
T13144 25169-25182 NN denotes tumorigenesis
T13145 25183-25185 VBZ denotes is
T13146 25186-25188 DT denotes an
T13147 25189-25198 JJ denotes increased
T13148 25199-25204 NN denotes level
T13149 25205-25207 IN denotes of
T13150 25208-25213 NNS denotes DNMTs
T13151 25214-25220 IN denotes during
T13152 25221-25224 DT denotes the
T13153 25225-25237 JJ denotes pathogenetic
T13154 25238-25245 NN denotes process
T13155 25245-25246 . denotes .
T13156 25247-25249 IN denotes In
T13157 25250-25255 NN denotes colon
T13158 25255-25256 , denotes ,
T13159 25257-25261 NN denotes lung
T13160 25262-25265 CC denotes and
T13161 25266-25277 JJ denotes hematologic
T13162 25278-25290 NNS denotes malignancies
T13163 25290-25291 , denotes ,
T13164 25292-25306 NN denotes overexpression
T13165 25307-25309 IN denotes of
T13166 25310-25315 NNP denotes DNMT1
T13167 25315-25316 , denotes ,
T13168 25317-25318 DT denotes a
T13169 25319-25330 NN denotes maintenance
T13170 25331-25335 NNP denotes DNMT
T13171 25335-25336 , denotes ,
T13172 25337-25340 VBZ denotes has
T13173 25341-25345 VBN denotes been
T13174 25346-25354 VBN denotes detected
T13175 25355-25356 -LRB- denotes (
T13176 25356-25358 CD denotes 39
T13177 25359-25361 CD denotes 41
T13178 25361-25362 -RRB- denotes )
T13179 25362-25363 . denotes .
T13180 25364-25375 RB denotes Furthermore
T13181 25375-25376 , denotes ,
T13182 25377-25379 PRP denotes it
T13183 25380-25383 VBZ denotes has
T13184 25384-25388 VBN denotes been
T13185 25389-25394 VBN denotes shown
T13186 25395-25399 IN denotes that
T13187 25400-25403 NNP denotes CML
T13188 25404-25409 NNS denotes cells
T13189 25410-25412 IN denotes in
T13190 25413-25416 DT denotes the
T13191 25417-25422 JJ denotes acute
T13192 25423-25428 NN denotes phase
T13193 25429-25438 VBD denotes exhibited
T13194 25439-25447 JJ denotes elevated
T13195 25448-25454 NNS denotes levels
T13196 25455-25457 IN denotes of
T13197 25458-25461 DT denotes the
T13198 25462-25467 CD denotes three
T13199 25468-25473 VBN denotes known
T13200 25474-25479 NNP denotes DNMTs
T13201 25479-25480 , denotes ,
T13202 25481-25486 IN denotes while
T13203 25487-25490 NNP denotes CML
T13204 25491-25496 NNS denotes cells
T13205 25497-25499 IN denotes in
T13206 25500-25507 JJ denotes chronic
T13207 25508-25513 NN denotes phase
T13208 25514-25523 VBD denotes expressed
T13209 25524-25530 JJ denotes normal
T13210 25531-25537 NNS denotes levels
T13211 25538-25540 IN denotes of
T13212 25541-25546 NNP denotes DNMTs
T13213 25547-25549 IN denotes if
T13214 25550-25558 VBN denotes compared
T13215 25559-25563 IN denotes with
T13216 25564-25570 JJ denotes normal
T13217 25571-25575 NN denotes bone
T13218 25576-25582 NN denotes marrow
T13219 25583-25588 NNS denotes cells
T13220 25589-25590 -LRB- denotes (
T13221 25590-25592 CD denotes 25
T13222 25592-25593 -RRB- denotes )
T13223 25593-25594 . denotes .
T13224 25595-25608 RB denotes Interestingly
T13225 25608-25609 , denotes ,
T13226 25610-25611 DT denotes a
T13227 25612-25620 JJ denotes positive
T13228 25621-25632 NN denotes correlation
T13229 25633-25640 IN denotes between
T13230 25641-25646 CD denotes DNMT1
T13231 25647-25657 NN denotes expression
T13232 25658-25664 NNS denotes levels
T13233 25665-25668 CC denotes and
T13234 25669-25685 NN denotes hypermethylation
T13235 25686-25688 IN denotes of
T13236 25689-25697 NNP denotes p15INK4b
T13237 25698-25701 VBZ denotes has
T13238 25702-25706 VBN denotes been
T13239 25707-25715 VBN denotes detected
T13240 25716-25718 IN denotes in
T13241 25719-25722 NNP denotes AML
T13242 25723-25724 -LRB- denotes (
T13243 25724-25726 CD denotes 25
T13244 25726-25727 -RRB- denotes )
T13245 25727-25728 . denotes .
T13246 25729-25731 IN denotes In
T13247 25732-25736 DT denotes this
T13248 25737-25741 NN denotes work
T13249 25741-25742 , denotes ,
T13250 25743-25745 PRP denotes we
T13251 25746-25749 VBD denotes did
T13252 25750-25753 RB denotes not
T13253 25754-25760 VB denotes detect
T13254 25761-25772 JJ denotes significant
T13255 25773-25777 NNP denotes mRNA
T13256 25778-25788 NN denotes expression
T13257 25789-25800 NNS denotes differences
T13258 25801-25803 IN denotes of
T13259 25804-25812 VBN denotes selected
T13260 25813-25817 NNP denotes DNMT
T13261 25818-25820 CC denotes or
T13262 25821-25824 NNP denotes MBP
T13263 25824-25825 , denotes ,
T13264 25826-25832 VBG denotes making
T13265 25833-25835 PRP denotes it
T13266 25836-25838 DT denotes an
T13267 25839-25847 JJ denotes unlikely
T13268 25848-25853 NN denotes cause
T13269 25854-25857 IN denotes for
T13270 25858-25861 DT denotes the
T13271 25862-25870 JJ denotes observed
T13272 25871-25882 NN denotes methylation
T13273 25883-25886 CC denotes and
T13274 25887-25891 RB denotes thus
T13275 25892-25897 JJ denotes IRF-4
T13276 25898-25908 NN denotes expression
T13277 25909-25920 NNS denotes differences
T13278 25921-25923 IN denotes in
T13279 25924-25932 NN denotes leukemia
T13280 25933-25938 NNS denotes cells
T13281 25938-25939 . denotes .
T13282 25940-25943 DT denotes The
T13283 25944-25951 NN denotes finding
T13284 25952-25956 WDT denotes that
T13285 25957-25962 NNP denotes IRF-4
T13286 25963-25973 NN denotes expression
T13287 25974-25976 VBZ denotes is
T13288 25977-25985 VBN denotes silenced
T13289 25986-25988 IN denotes by
T13290 25989-25997 NN denotes promoter
T13291 25998-26014 NN denotes hypermethylation
T13292 26015-26020 MD denotes might
T13293 26021-26030 VB denotes represent
T13294 26031-26032 DT denotes a
T13295 26033-26042 NN denotes mechanism
T13296 26043-26047 WDT denotes that
T13297 26048-26056 VBZ denotes accounts
T13298 26057-26060 IN denotes for
T13299 26061-26064 DT denotes the
T13300 26065-26075 RB denotes previously
T13301 26076-26084 JJ denotes observed
T13302 26085-26089 NN denotes loss
T13303 26090-26092 IN denotes of
T13304 26093-26098 NN denotes IRF-4
T13305 26099-26109 NN denotes expression
T13306 26110-26112 IN denotes in
T13307 26113-26116 NNP denotes CML
T13308 26116-26117 . denotes .
T13309 26118-26124 RB denotes Indeed
T13310 26124-26125 , denotes ,
T13311 26126-26133 JJ denotes several
T13312 26134-26142 JJ denotes clinical
T13313 26143-26149 NNS denotes trials
T13314 26150-26154 IN denotes with
T13315 26155-26163 NN denotes leukemia
T13316 26164-26172 NNS denotes patients
T13317 26173-26176 CC denotes and
T13318 26177-26185 NNS denotes patients
T13319 26186-26190 IN denotes with
T13320 26191-26206 JJ denotes myelodysplastic
T13321 26207-26216 NNS denotes syndromes
T13322 26217-26229 VBD denotes demonstrated
T13323 26230-26233 DT denotes the
T13324 26234-26243 JJ denotes potential
T13325 26244-26252 JJ denotes clinical
T13326 26253-26260 NN denotes benefit
T13327 26261-26263 IN denotes of
T13328 26264-26265 DT denotes a
T13329 26266-26275 NN denotes treatment
T13330 26276-26280 IN denotes with
T13331 26281-26294 VBG denotes demethylating
T13332 26295-26301 NNS denotes agents
T13333 26302-26303 -LRB- denotes (
T13334 26303-26305 CD denotes 42
T13335 26306-26308 CD denotes 45
T13336 26308-26309 -RRB- denotes )
T13337 26309-26310 . denotes .
T13338 26311-26314 DT denotes The
T13339 26315-26325 NN denotes expression
T13340 26326-26328 IN denotes of
T13341 26329-26336 DT denotes another
T13342 26337-26340 NNP denotes IRF
T13343 26340-26341 , denotes ,
T13344 26342-26345 NNP denotes IFN
T13345 26346-26355 NN denotes consensus
T13346 26356-26364 NN denotes sequence
T13347 26365-26372 JJ denotes binding
T13348 26373-26380 NN denotes protein
T13349 26381-26382 -LRB- denotes (
T13350 26382-26391 NNP denotes ICSBP/IRF
T13351 26391-26393 CD denotes -8
T13352 26393-26394 -RRB- denotes )
T13353 26394-26395 , denotes ,
T13354 26396-26398 VBZ denotes is
T13355 26399-26407 VBN denotes impaired
T13356 26408-26410 IN denotes in
T13357 26411-26418 JJ denotes myeloid
T13358 26419-26428 NNS denotes leukemias
T13359 26429-26439 RB denotes especially
T13360 26440-26443 NNP denotes CML
T13361 26444-26445 -LRB- denotes (
T13362 26445-26453 CD denotes 27,46,47
T13363 26453-26454 -RRB- denotes )
T13364 26454-26455 . denotes .
T13365 26456-26459 CC denotes But
T13366 26460-26462 IN denotes in
T13367 26463-26471 NN denotes contrast
T13368 26472-26474 TO denotes to
T13369 26475-26480 NNP denotes IRF-4
T13370 26480-26481 , denotes ,
T13371 26482-26485 DT denotes the
T13372 26486-26490 NN denotes loss
T13373 26491-26493 IN denotes of
T13374 26494-26498 DT denotes this
T13375 26499-26502 NNP denotes IRF
T13376 26503-26508 MD denotes could
T13377 26509-26512 RB denotes not
T13378 26513-26515 VB denotes be
T13379 26516-26524 VBN denotes reverted
T13380 26525-26527 IN denotes in
T13381 26528-26542 JJ denotes ICSBP-negative
T13382 26543-26547 NN denotes cell
T13383 26548-26553 NNS denotes lines
T13384 26554-26555 -LRB- denotes (
T13385 26555-26559 NN denotes EM-2
T13386 26559-26560 , denotes ,
T13387 26561-26567 NNP denotes CML-T1
T13388 26567-26568 , denotes ,
T13389 26569-26574 NNP denotes K-562
T13390 26575-26578 CC denotes and
T13391 26579-26586 NNP denotes LAMA-84
T13392 26586-26587 -RRB- denotes )
T13393 26588-26590 IN denotes by
T13394 26591-26600 NN denotes treatment
T13395 26601-26605 IN denotes with
T13396 26606-26611 NNP denotes AzadC
T13397 26612-26613 -LRB- denotes (
T13398 26613-26619 NNP denotes Figure
T13399 26620-26621 CD denotes 6
T13400 26621-26622 -RRB- denotes )
T13401 26623-26626 CC denotes and
T13402 26627-26632 NNP denotes AzadC
T13403 26633-26636 VBZ denotes has
T13404 26637-26639 DT denotes no
T13405 26640-26646 NN denotes effect
T13406 26647-26649 IN denotes on
T13407 26650-26655 NNP denotes ICSBP
T13408 26656-26662 NNS denotes levels
T13409 26663-26665 IN denotes in
T13410 26666-26680 JJ denotes ICSBP-positive
T13411 26681-26686 NNP denotes U-937
T13412 26687-26692 NNS denotes cells
T13413 26693-26694 -LRB- denotes (
T13414 26694-26700 NN denotes Figure
T13415 26701-26702 CD denotes 6
T13416 26702-26703 -RRB- denotes )
T13417 26703-26704 . denotes .
T13418 26705-26710 DT denotes These
T13419 26711-26715 NNS denotes data
T13420 26716-26723 VBP denotes suggest
T13421 26724-26725 DT denotes a
T13422 26726-26734 JJ denotes distinct
T13423 26735-26745 JJ denotes regulatory
T13424 26746-26755 NN denotes mechanism
T13425 26756-26759 IN denotes for
T13426 26760-26765 DT denotes these
T13427 26766-26769 CD denotes two
T13428 26770-26774 NNS denotes IRFs
T13429 26774-26775 . denotes .
T13430 26776-26781 NN denotes IRF-4
T13431 26781-26782 , denotes ,
T13432 26783-26790 JJ denotes similar
T13433 26791-26793 TO denotes to
T13434 26794-26798 JJ denotes many
T13435 26799-26804 JJ denotes other
T13436 26805-26814 JJ denotes classical
T13437 26815-26820 NN denotes tumor
T13438 26821-26831 NN denotes suppressor
T13439 26832-26837 NNS denotes genes
T13440 26838-26846 NNP denotes p15INK4b
T13441 26846-26847 , denotes ,
T13442 26848-26856 NNP denotes p16INK4a
T13443 26857-26859 CC denotes or
T13444 26860-26863 NN denotes p53
T13445 26863-26864 , denotes ,
T13446 26865-26868 MD denotes may
T13447 26869-26873 RB denotes thus
T13448 26874-26876 VB denotes be
T13449 26877-26878 DT denotes a
T13450 26879-26886 NN denotes subject
T13451 26887-26889 IN denotes of
T13452 26890-26901 NNS denotes alterations
T13453 26902-26904 IN denotes in
T13454 26905-26908 DT denotes the
T13455 26909-26917 NN denotes promoter
T13456 26918-26929 NN denotes methylation
T13457 26930-26936 NN denotes status
T13458 26937-26944 VBG denotes leading
T13459 26945-26947 TO denotes to
T13460 26948-26958 NN denotes expression
T13461 26959-26966 NNS denotes changes
T13462 26966-26967 , denotes ,
T13463 26968-26973 WDT denotes which
T13464 26974-26979 MD denotes might
T13465 26980-26990 VB denotes contribute
T13466 26991-26993 TO denotes to
T13467 26994-26997 DT denotes the
T13468 26998-27008 NN denotes initiation
T13469 27009-27015 CC denotes and/or
T13470 27016-27027 NN denotes progression
T13471 27028-27030 IN denotes of
T13472 27031-27037 NN denotes cancer
T13473 27037-27038 . denotes .
T13474 27039-27044 RB denotes Still
T13475 27044-27045 , denotes ,
T13476 27046-27049 DT denotes the
T13477 27050-27057 JJ denotes obvious
T13478 27058-27068 JJ denotes functional
T13479 27069-27078 NN denotes diversity
T13480 27079-27081 IN denotes of
T13481 27082-27087 NN denotes IRF-4
T13482 27088-27095 VBZ denotes remains
T13483 27096-27106 JJ denotes remarkable
T13484 27107-27110 CC denotes and
T13485 27111-27114 MD denotes can
T13486 27114-27117 RB denotes not
T13487 27118-27120 VB denotes be
T13488 27121-27126 RB denotes fully
T13489 27127-27136 VBN denotes explained
T13490 27137-27139 IN denotes by
T13491 27140-27143 DT denotes the
T13492 27144-27149 NN denotes IRF-4
T13493 27150-27158 NN denotes promoter
T13494 27159-27170 NN denotes methylation
T13495 27171-27177 NN denotes status
T13496 27177-27178 . denotes .
T13497 27179-27182 IN denotes For
T13498 27183-27190 NN denotes example
T13499 27190-27191 , denotes ,
T13500 27192-27197 NN denotes IRF-4
T13501 27198-27200 VBZ denotes is
T13502 27201-27210 RB denotes primarily
T13503 27211-27216 VBN denotes known
T13504 27217-27220 IN denotes for
T13505 27221-27224 PRP$ denotes its
T13506 27225-27234 JJ denotes oncogenic
T13507 27235-27243 NNS denotes features
T13508 27243-27244 . denotes .
T13509 27245-27247 IN denotes In
T13510 27248-27256 JJ denotes multiple
T13511 27257-27264 NN denotes myeloma
T13512 27265-27266 -LRB- denotes (
T13513 27266-27268 NNP denotes MM
T13514 27268-27269 -RRB- denotes )
T13515 27270-27271 DT denotes a
T13516 27272-27285 NN denotes translocation
T13517 27286-27288 IN denotes on
T13518 27289-27299 NN denotes chromosome
T13519 27300-27303 CD denotes 14q
T13520 27304-27307 VBD denotes was
T13521 27308-27316 VBN denotes reported
T13522 27317-27319 TO denotes to
T13523 27320-27324 VB denotes lead
T13524 27325-27327 TO denotes to
T13525 27328-27329 DT denotes a
T13526 27330-27336 NN denotes fusion
T13527 27337-27341 NN denotes gene
T13528 27342-27344 IN denotes of
T13529 27345-27359 NN denotes immunoglobulin
T13530 27360-27371 NN denotes heavy-chain
T13531 27372-27373 -LRB- denotes (
T13532 27373-27376 NNP denotes IgH
T13533 27376-27377 -RRB- denotes )
T13534 27378-27381 CC denotes and
T13535 27382-27387 JJ denotes IRF-4
T13536 27388-27397 VBG denotes resulting
T13537 27398-27400 IN denotes in
T13538 27401-27402 DT denotes a
T13539 27403-27413 JJ denotes subsequent
T13540 27414-27428 NN denotes overexpression
T13541 27429-27431 IN denotes of
T13542 27432-27437 NNP denotes IRF-4
T13543 27438-27439 -LRB- denotes (
T13544 27439-27444 CD denotes 48,49
T13545 27444-27445 -RRB- denotes )
T13546 27445-27446 . denotes .
T13547 27447-27449 IN denotes In
T13548 27450-27458 NN denotes addition
T13549 27458-27459 , denotes ,
T13550 27460-27468 JJ denotes abundant
T13551 27469-27474 NN denotes IRF-4
T13552 27475-27485 NN denotes expression
T13553 27486-27489 VBD denotes was
T13554 27490-27495 VBN denotes found
T13555 27496-27498 TO denotes to
T13556 27499-27501 VB denotes be
T13557 27502-27503 DT denotes a
T13558 27504-27510 NN denotes marker
T13559 27511-27514 IN denotes for
T13560 27515-27522 JJ denotes various
T13561 27523-27530 NNS denotes subsets
T13562 27531-27533 IN denotes of
T13563 27534-27543 NNS denotes lymphomas
T13564 27543-27544 , denotes ,
T13565 27545-27549 JJ denotes such
T13566 27550-27552 IN denotes as
T13567 27553-27560 NN denotes diffuse
T13568 27561-27566 JJ denotes large
T13569 27567-27573 NNP denotes B-cell
T13570 27574-27583 NNS denotes lymphomas
T13571 27583-27584 , denotes ,
T13572 27585-27592 JJ denotes primary
T13573 27593-27601 NN denotes effusion
T13574 27602-27610 NN denotes lymphoma
T13575 27610-27611 , denotes ,
T13576 27612-27615 CC denotes and
T13577 27616-27624 JJ denotes marginal
T13578 27625-27629 NN denotes zone
T13579 27630-27638 NN denotes lymphoma
T13580 27638-27639 , denotes ,
T13581 27640-27643 CC denotes and
T13582 27644-27649 NN denotes adult
T13583 27650-27656 NN denotes T-cell
T13584 27657-27665 NN denotes leukemia
T13585 27666-27667 -LRB- denotes (
T13586 27667-27675 CD denotes 11,31,50
T13587 27676-27678 CD denotes 52
T13588 27678-27679 -RRB- denotes )
T13589 27679-27680 . denotes .
T13590 27681-27685 DT denotes This
T13591 27686-27691 VBZ denotes draws
T13592 27692-27693 DT denotes a
T13593 27694-27698 RBR denotes more
T13594 27699-27706 JJ denotes complex
T13595 27707-27714 NN denotes picture
T13596 27715-27717 IN denotes of
T13597 27718-27721 DT denotes the
T13598 27722-27726 NN denotes role
T13599 27727-27729 IN denotes of
T13600 27730-27735 NN denotes IRF-4
T13601 27735-27736 . denotes .
T13602 27737-27752 NN denotes Down-regulation
T13603 27753-27755 IN denotes of
T13604 27756-27761 NN denotes IRF-4
T13605 27762-27765 MD denotes may
T13606 27766-27773 VB denotes promote
T13607 27774-27788 NN denotes leukemogenesis
T13608 27789-27791 IN denotes in
T13609 27792-27799 JJ denotes myeloid
T13610 27800-27804 NN denotes cell
T13611 27805-27812 NN denotes context
T13612 27813-27814 -LRB- denotes (
T13613 27814-27815 LS denotes 3
T13614 27815-27816 -RRB- denotes )
T13615 27816-27817 , denotes ,
T13616 27818-27823 WDT denotes which
T13617 27824-27827 VBD denotes was
T13618 27828-27836 RB denotes recently
T13619 27837-27846 VBN denotes confirmed
T13620 27847-27849 IN denotes in
T13621 27850-27855 NNP denotes IRF-4
T13622 27855-27856 FW denotes −
T13623 27856-27857 FW denotes /
T13624 27857-27858 FW denotes −
T13625 27859-27864 NNP denotes ICSBP
T13626 27864-27865 FW denotes −
T13627 27865-27866 FW denotes /
T13628 27866-27867 FW denotes −
T13629 27868-27874 JJ denotes double
T13630 27875-27884 NN denotes knock-out
T13631 27885-27889 NNS denotes mice
T13632 27890-27891 -LRB- denotes (
T13633 27891-27893 CD denotes 53
T13634 27893-27894 -RRB- denotes )
T13635 27894-27895 , denotes ,
T13636 27896-27901 IN denotes while
T13637 27902-27907 NNP denotes IRF-4
T13638 27908-27921 NN denotes up-regulation
T13639 27922-27925 MD denotes may
T13640 27926-27932 VB denotes induce
T13641 27933-27934 DT denotes a
T13642 27935-27941 NN denotes growth
T13643 27942-27951 NN denotes advantage
T13644 27952-27954 IN denotes in
T13645 27955-27964 NNS denotes lymphomas
T13646 27965-27967 CC denotes or
T13647 27968-27970 NNP denotes MM
T13648 27971-27972 -LRB- denotes (
T13649 27972-27974 CD denotes 48
T13650 27974-27975 -RRB- denotes )
T13651 27975-27976 . denotes .
T13652 27977-27982 VBN denotes Taken
T13653 27983-27991 RB denotes together
T13654 27991-27992 , denotes ,
T13655 27993-27996 PRP$ denotes our
T13656 27997-28001 NNS denotes data
T13657 28002-28009 VBP denotes suggest
T13658 28010-28014 IN denotes that
T13659 28015-28020 JJ denotes IRF-4
T13660 28021-28029 NN denotes promoter
T13661 28030-28041 NN denotes methylation
T13662 28042-28051 VBZ denotes regulates
T13663 28052-28057 JJ denotes IRF-4
T13664 28058-28068 NN denotes expression
T13665 28068-28069 , denotes ,
T13666 28070-28073 CC denotes and
T13667 28074-28078 IN denotes that
T13668 28079-28087 JJ denotes aberrant
T13669 28088-28098 NN denotes expression
T13670 28099-28101 IN denotes of
T13671 28102-28107 NN denotes IRF-4
T13672 28108-28110 IN denotes in
T13673 28111-28118 JJ denotes certain
T13674 28119-28124 NNS denotes types
T13675 28125-28127 IN denotes of
T13676 28128-28136 NN denotes leukemia
T13677 28137-28140 MD denotes may
T13678 28141-28143 VB denotes be
T13679 28144-28145 DT denotes a
T13680 28146-28157 NN denotes consequence
T13681 28158-28160 IN denotes of
T13682 28161-28166 NN denotes IRF-4
T13683 28167-28175 NN denotes promoter
T13684 28176-28192 NN denotes hypermethylation
T13685 28192-28193 . denotes .
T9895 19871-19877 NN denotes effect
T9896 19878-19880 IN denotes of
T9897 19881-19894 JJ denotes methylational
T9898 19895-19901 NN denotes status
T9899 19902-19904 IN denotes on
T9900 19905-19910 NN denotes IRF-4
T9901 19911-19919 NN denotes promoter
T9902 19920-19928 NN denotes activity
T9903 19929-19931 PRP denotes we
T9904 19932-19941 VBD denotes performed
T9905 19942-19950 NN denotes reporter
T9906 19951-19955 NN denotes gene
T9907 19956-19962 NNS denotes assays
T9908 19963-19967 IN denotes with
T9909 19968-19973 JJ denotes IRF-4
T9910 19974-19982 NN denotes promoter
T9911 19983-19993 NNS denotes constructs
T9912 19994-20000 IN denotes before
R343 T454 T453 prep in,aberration
R344 T455 T457 amod chronic,leukemia
R345 T456 T457 amod myeloid,leukemia
R346 T457 T454 pobj leukemia,in
R347 T458 T459 punct (,CML
R348 T459 T457 appos CML,leukemia
R445 T556 T558 amod altered,expression
R446 T557 T558 compound IRF-4,expression
R447 T558 T555 pobj expression,of
R448 T559 T558 prep in,expression
R449 T560 T561 amod hematopoietic,cells
R450 T561 T559 pobj cells,in
R451 T562 T569 punct ",",found
R452 T563 T567 det the,status
R453 T564 T567 compound IRF-4,status
R454 T565 T567 compound promoter,status
R515 T626 T624 pobj cells,in
R516 T627 T615 punct .,identified
R517 T628 T632 npadvmod Third,determined
R518 T629 T632 punct ",",determined
R519 T630 T632 nsubj we,determined
R520 T631 T632 advmod clearly,determined
R521 T632 T632 ROOT determined,determined
R522 T633 T634 compound promoter,methylation
R523 T634 T632 dobj methylation,determined
R524 T635 T632 prep as,determined
R525 T636 T637 det a,mechanism
R526 T637 T635 pobj mechanism,as
R527 T638 T637 prep for,mechanism
R528 T639 T640 compound IRF-4,down-regulation
R529 T640 T638 pobj down-regulation,for
R530 T641 T632 prep via,determined
R326 T437 T433 prep in,hypermethylation
R327 T438 T440 det the,region
R328 T439 T440 compound promoter,region
R329 T440 T437 pobj region,in
R330 T441 T447 mark Although,shown
R331 T442 T444 det the,translocation
R332 T443 T444 amod bcr-abl,translocation
R333 T444 T447 nsubjpass translocation,shown
R334 T445 T447 aux has,shown
R335 T446 T447 auxpass been,shown
R336 T447 T463 advcl shown,is
R337 T448 T449 aux to,be
R338 T449 T447 xcomp be,shown
R339 T450 T453 det the,aberration
R340 T451 T453 amod causative,aberration
R341 T452 T453 amod genetic,aberration
R342 T453 T449 attr aberration,be
R349 T460 T447 punct ),shown
R350 T461 T463 punct ",",is
R351 T462 T463 expl there,is
R352 T463 T463 ROOT is,is
R353 T464 T465 amod mounting,evidence
R354 T465 T463 attr evidence,is
R355 T466 T488 mark that,implicated
R356 T467 T468 det the,deregulation
R357 T468 T488 nsubjpass deregulation,implicated
R358 T469 T468 prep of,deregulation
R359 T470 T471 amod other,genes
R360 T471 T469 pobj genes,of
R361 T472 T471 punct ",",genes
R362 T473 T474 amod such,as
R363 T474 T471 prep as,genes
R364 T475 T480 det the,factor
R365 T476 T477 compound transcription,factor
R366 T477 T480 nmod factor,factor
R367 T478 T480 nmod interferon,factor
R368 T479 T480 amod regulatory,factor
R369 T480 T474 pobj factor,as
R370 T481 T480 nummod 4,factor
R371 T482 T480 punct (,factor
R372 T483 T480 appos IRF-4,factor
R373 T484 T480 punct ),factor
R374 T485 T486 punct ",",is
R375 T486 T488 auxpass is,implicated
R376 T487 T488 advmod also,implicated
R377 T488 T465 acl implicated,evidence
R378 T489 T488 prep in,implicated
R379 T490 T491 det the,pathogenesis
R380 T491 T489 pobj pathogenesis,in
R381 T492 T491 prep of,pathogenesis
R410 T521 T523 punct ",",investigated
R411 T522 T523 nsubj we,investigated
R412 T523 T523 ROOT investigated,investigated
R413 T524 T532 mark whether,involved
R414 T525 T527 compound IRF-4,methylation
R415 T526 T527 compound promoter,methylation
R416 T527 T532 nsubjpass methylation,involved
R417 T528 T527 cc or,methylation
R418 T529 T527 conj mutation,methylation
R419 T530 T532 aux may,involved
R420 T531 T532 auxpass be,involved
R421 T532 T523 ccomp involved,investigated
R422 T533 T532 prep in,involved
R423 T534 T535 det the,regulation
R424 T535 T533 pobj regulation,in
R425 T536 T535 prep of,regulation
R426 T537 T538 compound IRF-4,expression
R427 T538 T536 pobj expression,of
R428 T539 T535 prep in,regulation
R429 T540 T541 compound leukemia,cells
R430 T541 T539 pobj cells,in
R431 T542 T523 punct .,investigated
R432 T543 T551 mark Whereas,excluded
R433 T544 T545 compound promoter,mutations
R434 T545 T551 nsubjpass mutations,excluded
R435 T546 T545 cc or,mutations
R436 T547 T548 amod structural,rearrangements
R437 T548 T545 conj rearrangements,mutations
R438 T549 T551 aux could,excluded
R439 T550 T551 auxpass be,excluded
R440 T551 T569 advcl excluded,found
R441 T552 T551 prep as,excluded
R442 T553 T554 det a,cause
R443 T554 T552 pobj cause,as
R444 T555 T554 prep of,cause
R455 T566 T567 compound methylation,status
R456 T567 T569 nsubjpass status,found
R457 T568 T569 auxpass was,found
R458 T569 T569 ROOT found,found
R459 T570 T572 aux to,influence
R460 T571 T572 advmod significantly,influence
R461 T572 T569 xcomp influence,found
R462 T573 T574 compound IRF-4,transcription
R463 T574 T572 dobj transcription,influence
R464 T575 T569 punct .,found
R465 T576 T592 advmod First,resulted
R466 T577 T592 punct ",",resulted
R467 T578 T592 nsubj treatment,resulted
R468 T579 T578 prep of,treatment
R469 T580 T581 amod IRF-4-negative,lymphoid
R470 T581 T579 pobj lymphoid,of
R471 T582 T581 punct ",",lymphoid
R472 T583 T581 conj myeloid,lymphoid
R473 T584 T583 cc and,myeloid
R474 T585 T583 conj monocytic,myeloid
R475 T586 T587 compound cell,lines
R476 T587 T578 pobj lines,treatment
R477 T588 T587 prep with,lines
R478 T589 T591 det the,5-aza-2-deoxycytidine
R479 T590 T591 compound methylation-inhibitor,5-aza-2-deoxycytidine
R480 T591 T588 pobj 5-aza-2-deoxycytidine,with
R481 T592 T592 ROOT resulted,resulted
R482 T593 T592 prep in,resulted
R483 T594 T595 det a,time
R484 T595 T593 pobj time,in
R485 T596 T592 punct -,resulted
R486 T597 T592 cc and,resulted
R487 T598 T599 amod concentration-dependent,increase
R488 T599 T605 nmod increase,levels
R489 T600 T599 prep of,increase
R490 T601 T602 compound IRF-4,mRNA
R491 T602 T600 pobj mRNA,of
R492 T603 T599 cc and,increase
R493 T604 T605 compound protein,levels
R494 T605 T592 conj levels,resulted
R495 T606 T592 punct .,resulted
R496 T607 T615 advmod Second,identified
R497 T608 T615 punct ",",identified
R498 T609 T615 advcl using,identified
R499 T610 T615 npadvmod a,identified
R500 T611 T615 npadvmod restriction-PCR-assay,identified
R501 T612 T611 cc and,restriction-PCR-assay
R502 T613 T611 conj bisulfite-sequencing,restriction-PCR-assay
R503 T614 T615 nsubj we,identified
R504 T615 T615 ROOT identified,identified
R505 T616 T617 advmod specifically,methylated
R506 T617 T619 amod methylated,sites
R507 T618 T619 compound CpG,sites
R508 T619 T615 dobj sites,identified
R509 T620 T619 prep in,sites
R510 T621 T620 pobj IRF-4-negative,in
R511 T622 T621 cc but,IRF-4-negative
R512 T623 T620 neg not,in
R513 T624 T620 prep in,in
R514 T625 T626 amod IRF-4-positive,cells
R531 T642 T644 compound reporter,assays
R532 T643 T644 compound gene,assays
R533 T644 T641 pobj assays,via
R534 T645 T632 punct ",",determined
R535 T646 T632 cc but,determined
R536 T647 T649 aux did,detect
R537 T648 T649 neg not,detect
R538 T649 T632 conj detect,determined
R539 T650 T651 det an,association
R540 T651 T649 dobj association,detect
R541 T652 T651 prep of,association
R542 T653 T654 amod methylational,status
R543 T654 T652 pobj status,of
R544 T655 T649 cc and,detect
R545 T656 T657 compound mRNA,expression
R546 T657 T649 conj expression,detect
R547 T658 T657 prep of,expression
R548 T659 T660 compound DNA,methyltransferases
R549 T660 T658 pobj methyltransferases,of
R550 T661 T660 cc or,methyltransferases
R551 T662 T663 amod methyl-CpG-binding,proteins
R552 T663 T660 conj proteins,methyltransferases
R553 T664 T632 punct .,determined
R554 T665 T669 advmod Together,suggest
R555 T666 T669 punct ",",suggest
R556 T667 T668 det these,data
R557 T668 T669 nsubj data,suggest
R558 T669 T669 ROOT suggest,suggest
R559 T670 T674 nmod CpG,methylation
R560 T671 T672 amod site-specific,IRF-4
R561 T672 T674 compound IRF-4,methylation
R562 T673 T674 compound promoter,methylation
R563 T674 T669 dobj methylation,suggest
R564 T675 T669 prep as,suggest
R565 T676 T678 det a,mechanism
R566 T677 T678 amod putative,mechanism
R567 T678 T675 pobj mechanism,as
R568 T679 T678 prep of,mechanism
R569 T680 T682 amod down-regulated,expression
R570 T681 T682 compound IRF-4,expression
R571 T682 T679 pobj expression,of
R572 T683 T678 prep in,mechanism
R573 T684 T683 pobj leukemia,in
R574 T685 T669 punct .,suggest
R1351 T1728 T1729 punct (,CML
R1352 T1729 T1727 appos CML,leukemia
R1353 T1730 T1727 punct ),leukemia
R1354 T1731 T1731 ROOT is,is
R1355 T1732 T1735 det a,disorder
R1356 T1733 T1735 amod clonal,disorder
R1357 T1734 T1735 amod myeloproliferative,disorder
R1358 T1735 T1731 attr disorder,is
R1359 T1736 T1735 prep with,disorder
R1360 T1737 T1741 det a,course
R1361 T1738 T1741 amod typical,course
R1362 T1739 T1741 nummod three,course
R1363 T1740 T1741 amod phased,course
R1364 T1741 T1736 pobj course,with
R1365 T1742 T1741 punct (,course
R1366 T1743 T1741 appos chronic,course
R1367 T1744 T1741 punct ",",course
R1368 T1745 T1748 amod accelerated,phase
R1369 T1746 T1745 cc and,accelerated
R1370 T1747 T1748 compound blastic,phase
R1371 T1748 T1731 attr phase,is
R1372 T1749 T1731 punct ),is
R1373 T1750 T1731 advcl reflecting,is
R1374 T1751 T1752 det the,loss
R1375 T1752 T1750 dobj loss,reflecting
R1376 T1753 T1752 prep of,loss
R1377 T1754 T1753 pobj differentiation,of
R1378 T1755 T1754 cc and,differentiation
R1379 T1756 T1757 amod malignant,progress
R1380 T1757 T1754 conj progress,differentiation
R1381 T1758 T1760 nsubj which,leads
R1382 T1759 T1760 advmod inevitably,leads
R1383 T1760 T1757 relcl leads,progress
R1384 T1761 T1760 prep to,leads
R1385 T1762 T1761 pobj death,to
R1386 T1763 T1760 prep after,leads
R1387 T1764 T1766 det the,phase
R1388 T1765 T1766 amod blastic,phase
R1389 T1766 T1763 pobj phase,after
R1390 T1767 T1768 punct (,"1,2"
R1391 T1768 T1766 parataxis "1,2",phase
R1392 T1769 T1731 punct ),is
R1393 T1770 T1731 punct .,is
R1394 T1771 T1774 det The,aberration
R1395 T1772 T1774 nmod hallmark,aberration
R1396 T1773 T1774 amod genetic,aberration
R1397 T1774 T1777 nsubj aberration,is
R1398 T1775 T1774 prep of,aberration
R1399 T1776 T1775 pobj CML,of
R1400 T1777 T1777 ROOT is,is
R1401 T1778 T1782 det a,t
R1402 T1779 T1782 amod reciprocal,t
R1403 T1780 T1782 amod chromosomal,t
R1404 T1781 T1782 compound translocation,t
R1405 T1782 T1777 attr t,is
R1406 T1783 T1786 punct (,22
R1407 T1784 T1786 nummod 9,22
R1408 T1785 T1786 punct ;,22
R1409 T1786 T1782 appos 22,t
R1410 T1787 T1782 punct ),t
R1411 T1788 T1777 advcl leading,is
R1412 T1789 T1788 prep to,leading
R1413 T1790 T1789 pobj expression,to
R1414 T1791 T1790 prep of,expression
R1415 T1792 T1795 det a,gene
R1416 T1793 T1795 amod bcr-abl,gene
R1417 T1794 T1795 compound fusion,gene
R1418 T1795 T1791 pobj gene,of
R1419 T1796 T1795 punct ",",gene
R1420 T1797 T1801 det an,kinase
R1421 T1798 T1801 amod aberrant,kinase
R1422 T1799 T1801 amod activated,kinase
R1423 T1800 T1801 compound tyrosine,kinase
R1424 T1801 T1795 appos kinase,gene
R1425 T1802 T1803 punct (,2
R1426 T1803 T1801 appos 2,kinase
R1427 T1804 T1803 punct ),2
R1428 T1805 T1777 punct .,is
R1429 T1806 T1813 nsubj Treatment,prolongs
R1430 T1807 T1806 prep with,Treatment
R1431 T1808 T1809 compound interferon,α
R1432 T1809 T1807 pobj α,with
R1433 T1810 T1811 punct (,IFN-α
R1434 T1811 T1809 appos IFN-α,α
R1435 T1812 T1806 punct ),Treatment
R1436 T1813 T1813 ROOT prolongs,prolongs
R1437 T1814 T1813 dobj survival,prolongs
R1438 T1815 T1814 prep of,survival
R1439 T1816 T1817 compound CML,patients
R1440 T1817 T1815 pobj patients,of
R1441 T1818 T1813 cc and,prolongs
R1442 T1819 T1820 auxpass is,associated
R1443 T1820 T1813 conj associated,prolongs
R1444 T1821 T1820 prep with,associated
R1445 T1822 T1825 det a,response
R1446 T1823 T1825 amod complete,response
R1447 T1824 T1825 amod cytogenetic,response
R1448 T1825 T1821 pobj response,with
R1449 T1826 T1825 prep in,response
R1450 T1827 T1826 pobj 5,in
R1451 T1828 T1829 nummod 33,%
R1452 T1829 T1820 npadvmod %,associated
R1453 T1830 T1829 prep of,%
R1454 T1831 T1832 compound CML,patients
R1455 T1832 T1830 pobj patients,of
R1456 T1833 T1832 punct (,patients
R1457 T1834 T1832 appos "1,2",patients
R1458 T1835 T1820 punct ),associated
R1459 T1836 T1813 punct .,prolongs
R1460 T1837 T1840 advmod Recently,described
R1461 T1838 T1840 punct ",",described
R1462 T1839 T1840 nsubj we,described
R1463 T1840 T1840 ROOT described,described
R1464 T1841 T1843 det an,expression
R1465 T1842 T1843 amod impaired,expression
R1466 T1843 T1840 dobj expression,described
R1467 T1844 T1843 prep of,expression
R1468 T1845 T1848 det the,factor
R1469 T1846 T1848 nmod interferon,factor
R1470 T1847 T1848 amod regulatory,factor
R1471 T1848 T1844 pobj factor,of
R1472 T1849 T1848 nummod 4,factor
R1473 T1850 T1848 punct (,factor
R1474 T1851 T1848 appos IRF-4,factor
R1475 T1852 T1848 punct ),factor
R1476 T1853 T1843 prep in,expression
R1477 T1854 T1853 pobj CML,in
R1478 T1855 T1840 punct ",",described
R1479 T1856 T1840 advcl correlating,described
R1480 T1857 T1856 prep with,correlating
R1481 T1858 T1859 amod poor,response
R1482 T1859 T1857 pobj response,with
R1483 T1860 T1859 prep to,response
R1484 T1861 T1862 amod IFN-α,treatment
R1485 T1862 T1860 pobj treatment,to
R1486 T1863 T1864 punct (,3
R1487 T1864 T1856 parataxis 3,correlating
R1488 T1865 T1864 punct ),3
R1489 T1866 T1840 punct .,described
R1490 T1867 T1868 det The,cause
R1491 T1868 T1875 nsubj cause,remained
R1492 T1869 T1868 prep of,cause
R1493 T1870 T1871 det the,silencing
R1494 T1871 T1869 pobj silencing,of
R1495 T1872 T1871 prep of,silencing
R1496 T1873 T1874 amod IRF-4,level
R1497 T1874 T1872 pobj level,of
R1498 T1875 T1875 ROOT remained,remained
R1499 T1876 T1875 acomp unclear,remained
R1500 T1877 T1875 punct .,remained
R1501 T1878 T1884 nsubj Interferon,are
R1502 T1879 T1880 amod regulatory,factors
R1503 T1880 T1884 nsubj factors,are
R1504 T1881 T1882 punct (,IRFs
R1505 T1882 T1880 appos IRFs,factors
R1506 T1883 T1880 punct ),factors
R1507 T1884 T1884 ROOT are,are
R1508 T1885 T1886 det a,family
R1509 T1886 T1884 attr family,are
R1510 T1887 T1886 prep of,family
R1511 T1888 T1889 amod transcriptional,regulators
R1512 T1889 T1887 pobj regulators,of
R1513 T1890 T1886 acl defined,family
R1514 T1891 T1890 agent by,defined
R1515 T1892 T1894 det a,homology
R1516 T1893 T1894 compound characteristic,homology
R1517 T1894 T1891 pobj homology,by
R1518 T1895 T1894 prep in,homology
R1519 T1896 T1898 poss their,domain
R1520 T1897 T1898 amod DNA-binding,domain
R1521 T1898 T1895 pobj domain,in
R1522 T1899 T1884 punct .,are
R1523 T1900 T1901 nsubj They,play
R1524 T1901 T1901 ROOT play,play
R1525 T1902 T1904 det an,role
R1526 T1903 T1904 amod important,role
R1527 T1904 T1901 dobj role,play
R1528 T1905 T1901 prep in,play
R1529 T1906 T1907 det the,regulation
R1530 T1907 T1905 pobj regulation,in
R1531 T1908 T1907 prep of,regulation
R1532 T1909 T1910 amod various,genes
R1533 T1910 T1908 pobj genes,of
R1534 T1911 T1910 punct (,genes
R1535 T1912 T1913 amod such,as
R1536 T1913 T1910 prep as,genes
R1537 T1914 T1913 pobj IFNs,as
R1538 T1915 T1914 punct ",",IFNs
R1539 T1916 T1914 conj interleukins,IFNs
R1540 T1917 T1916 punct ",",interleukins
R1541 T1955 T1957 punct (,11
R1542 T1918 T1919 amod MHC,class
R1543 T1956 T1957 nummod 7,11
R1544 T1957 T1958 nmod 11,)
R1545 T1919 T1920 compound class,I/II
R1546 T1958 T1952 punct ),are
R1547 T1959 T1937 punct .,is
R1548 T1960 T1972 prep In,induced
R1549 T1920 T1907 appos I/II,regulation
R1550 T1961 T1960 pobj contrast,In
R1551 T1962 T1961 prep to,contrast
R1552 T1921 T1907 punct ),regulation
R1553 T1963 T1964 amod other,IRFs
R1554 T1964 T1962 pobj IRFs,to
R1555 T1965 T1964 punct ",",IRFs
R1556 T1966 T1972 nsubjpass expression,induced
R1557 T1967 T1966 prep of,expression
R1558 T1968 T1967 pobj IRF-4,of
R1559 T1922 T1907 punct ",",regulation
R1560 T1969 T1972 aux can,induced
R1561 T1923 T1901 conj apoptosis,play
R1562 T1970 T1972 neg not,induced
R1563 T1924 T1923 cc and,apoptosis
R1564 T1971 T1972 auxpass be,induced
R1565 T1972 T1972 ROOT induced,induced
R1566 T1973 T1972 agent by,induced
R1567 T1925 T1923 conj differentiation/maturation,apoptosis
R1568 T1974 T1973 pobj IFNs,by
R1569 T1975 T1972 punct ",",induced
R1570 T1976 T1972 cc but,induced
R1571 T1926 T1925 punct (,differentiation/maturation
R1572 T1977 T1972 conj by,induced
R1573 T1978 T1979 compound antigen,stimulation
R1574 T1927 T1925 nummod 4,differentiation/maturation
R1575 T1979 T1977 pobj stimulation,by
R1576 T1980 T1972 punct ",",induced
R1577 T1928 T1925 appos 6,differentiation/maturation
R1578 T1981 T1972 conj crosslinking,induced
R1579 T1982 T1981 prep of,crosslinking
R1580 T1983 T1982 punct T,of
R1581 T1929 T1925 punct ),differentiation/maturation
R1582 T1930 T1901 punct .,play
R1583 T1984 T1983 punct -,T
R1584 T1985 T1981 cc or,crosslinking
R1585 T1986 T1987 compound B-cell,receptors
R1586 T1987 T1981 conj receptors,crosslinking
R1587 T1988 T1987 cc or,receptors
R1588 T1989 T1987 conj phorbol-myristate-acetate,receptors
R1589 T1931 T1937 nsubj IRF-4,is
R1590 T1990 T1991 punct (,"10,11"
R1591 T1991 T1989 appos "10,11",phorbol-myristate-acetate
R1592 T1992 T1989 punct ),phorbol-myristate-acetate
R1593 T1932 T1935 punct (,LSIRF
R1594 T1993 T1981 punct .,crosslinking
R1595 T1994 T2009 nsubj Consistent,failed
R1596 T1933 T1934 amod ICSAT/Pip/MUM1,/
R1597 T1995 T1994 prep with,Consistent
R1598 T1996 T1997 det the,restriction
R1599 T1997 T1995 pobj restriction,with
R1600 T1998 T1997 prep of,restriction
R1601 T1934 T1935 compound /,LSIRF
R1602 T1999 T1998 pobj expression,of
R1603 T2000 T1999 prep to,expression
R1604 T2001 T2002 amod immunocompetent,cells
R1605 T2002 T2000 pobj cells,to
R1606 T2003 T1997 punct ",",restriction
R1607 T2004 T1997 appos mice,restriction
R1608 T1935 T1931 appos LSIRF,IRF-4
R1609 T2005 T1997 prep with,restriction
R1610 T2006 T2005 pobj deletion,with
R1611 T2007 T2006 prep of,deletion
R1612 T1936 T1935 punct ),LSIRF
R1613 T2008 T2007 pobj IRF-4,of
R1614 T2009 T2009 ROOT failed,failed
R1615 T2010 T2011 aux to,develop
R1616 T1937 T1937 ROOT is,is
R1617 T2011 T2009 xcomp develop,failed
R1618 T2012 T2016 amod mature,B
R1619 T1938 T1939 nummod one,member
R1620 T2013 T2012 cc and,mature
R1621 T2014 T2015 advmod functionally,active
R1622 T2015 T2012 conj active,mature
R1623 T1939 T1937 attr member,is
R1624 T2016 T2011 dobj B,develop
R1625 T2017 T2016 punct -,B
R1626 T1940 T1939 prep with,member
R1627 T1941 T1942 advmod very,restricted
R1628 T2018 T2016 cc and,B
R1629 T1942 T1944 amod restricted,pattern
R1630 T1943 T1944 compound expression,pattern
R1631 T2019 T2016 conj T-lymphocytes,B
R1632 T1944 T1940 pobj pattern,with
R1633 T1945 T1937 punct :,is
R1634 T2020 T2019 punct (,T-lymphocytes
R1635 T1946 T1947 compound Predominately,B
R1636 T2021 T2019 appos 12,T-lymphocytes
R1637 T1947 T1952 nsubj B,are
R1638 T2022 T2019 punct ),T-lymphocytes
R1639 T2023 T2009 punct ",",failed
R1640 T1948 T1947 punct -,B
R1641 T2024 T2009 cc and,failed
R1642 T2025 T2027 det the,expression
R1643 T1949 T1947 cc and,B
R1644 T2026 T2027 amod impaired,expression
R1645 T2027 T2034 nsubjpass expression,found
R1646 T2028 T2027 prep of,expression
R1647 T1950 T1951 amod activated,T-lymphocytes
R1648 T2029 T2028 pobj IRF-4,of
R1649 T2030 T2029 prep in,IRF-4
R1650 T2031 T2030 pobj CML,in
R1651 T1951 T1947 conj T-lymphocytes,B
R1652 T2032 T2034 auxpass was,found
R1653 T1952 T1952 ROOT are,are
R1654 T2033 T2034 advmod predominately,found
R1655 T2034 T2009 conj found,failed
R1656 T2035 T2034 prep in,found
R1657 T2036 T2035 pobj T-cells,in
R1658 T2037 T2036 punct (,T-cells
R1659 T1953 T1954 amod IRF-4,positive
R1660 T2038 T2036 appos 3,T-cells
R1661 T2039 T2036 punct ),T-cells
R1662 T2040 T2034 punct .,found
R1663 T1954 T1952 acomp positive,are
R1664 T2041 T2042 det These,data
R1665 T2042 T2043 nsubj data,suggest
R1666 T2043 T2043 ROOT suggest,suggest
R1667 T2052 T2051 prep of,function
R1668 T2044 T2046 det a,role
R1669 T2045 T2046 amod crucial,role
R1670 T2053 T2054 amod immune,cells
R1671 T2046 T2043 dobj role,suggest
R1672 T2047 T2046 prep for,role
R1673 T2048 T2047 pobj IRF-4,for
R1674 T2054 T2052 pobj cells,of
R1675 T2049 T2048 prep in,IRF-4
R1676 T2050 T2051 det the,function
R1677 T2051 T2049 pobj function,in
R1678 T2055 T2043 punct .,suggest
R1679 T2056 T2074 nsubj Methylation,is
R1680 T2057 T2056 prep of,Methylation
R1681 T2058 T2060 nmod dinucleotide,motifs
R1682 T2059 T2060 amod cytosine-guanosine,motifs
R1683 T2149 T2139 punct .,thought
R1684 T2150 T2155 nsubj Examples,are
R1685 T2060 T2057 pobj motifs,of
R1686 T2151 T2150 prep for,Examples
R1687 T2152 T2154 amod such,genes
R1688 T2153 T2154 amod aberrated,genes
R1689 T2061 T2060 punct (,motifs
R1690 T2154 T2151 pobj genes,for
R1691 T2155 T2155 ROOT are,are
R1692 T2156 T2155 attr MGMT,are
R1693 T2062 T2060 appos CpG,motifs
R1694 T2157 T2156 punct ",",MGMT
R1695 T2063 T2060 punct ),motifs
R1696 T2158 T2156 conj DAPK,MGMT
R1697 T2159 T2158 punct ",",DAPK
R1698 T2160 T2158 conj p14ARF,DAPK
R1699 T2161 T2160 punct ",",p14ARF
R1700 T2064 T2056 punct ",",Methylation
R1701 T2162 T2160 conj p15INK4b,p14ARF
R1702 T2065 T2066 advmod especially,in
R1703 T2163 T2162 punct ",",p15INK4b
R1704 T2066 T2056 prep in,Methylation
R1705 T2164 T2162 conj p16INK4a,p15INK4b
R1706 T2165 T2164 punct ",",p16INK4a
R1707 T2166 T2164 conj BRCA1,p16INK4a
R1708 T2167 T2166 punct ",",BRCA1
R1709 T2168 T2166 conj CDH13,BRCA1
R1710 T2067 T2068 compound CpG,islands
R1711 T2169 T2168 cc and,CDH13
R1712 T2170 T2168 conj APAF-1,CDH13
R1713 T2171 T2170 punct (,APAF-1
R1714 T2068 T2066 pobj islands,in
R1715 T2172 T2170 nummod 17,APAF-1
R1716 T2173 T2170 nummod 19,APAF-1
R1717 T2069 T2068 acl located,islands
R1718 T2174 T2170 punct ),APAF-1
R1719 T2175 T2155 punct .,are
R1720 T2176 T2181 prep In,known
R1721 T2070 T2069 prep in,located
R1722 T2177 T2176 pobj CML,In
R1723 T2178 T2181 punct ",",known
R1724 T2179 T2181 nsubjpass methylation,known
R1725 T2071 T2072 compound promoter,regions
R1726 T2180 T2181 auxpass is,known
R1727 T2181 T2181 ROOT known,known
R1728 T2182 T2183 aux to,regulate
R1729 T2072 T2070 pobj regions,in
R1730 T2183 T2181 xcomp regulate,known
R1731 T2184 T2183 dobj expression,regulate
R1732 T2185 T2184 prep of,expression
R1733 T2073 T2074 punct ",",is
R1734 T2186 T2187 det the,c-abl
R1735 T2187 T2185 pobj c-abl,of
R1736 T2074 T2074 ROOT is,is
R1737 T2188 T2187 punct ",",c-abl
R1738 T2189 T2191 det the,gene
R1739 T2190 T2191 compound bcr,gene
R1740 T2075 T2074 attr one,is
R1741 T2191 T2187 conj gene,c-abl
R1742 T2192 T2191 cc and,gene
R1743 T2193 T2191 conj others,gene
R1744 T2194 T2193 punct (,others
R1745 T2076 T2075 prep of,one
R1746 T2195 T2193 appos 20,others
R1747 T2077 T2078 det the,mechanisms
R1748 T2196 T2193 appos 23,others
R1749 T2197 T2193 punct ),others
R1750 T2198 T2181 punct ",",known
R1751 T2199 T2181 cc and,known
R1752 T2078 T2076 pobj mechanisms,of
R1753 T2200 T2201 det the,extent
R1754 T2201 T2210 nsubjpass extent,shown
R1755 T2202 T2201 prep of,extent
R1756 T2079 T2078 prep of,mechanisms
R1757 T2203 T2202 pobj methylation,of
R1758 T2204 T2201 prep in,extent
R1759 T2205 T2207 det the,promoter
R1760 T2206 T2207 amod c-abl,promoter
R1761 T2207 T2204 pobj promoter,in
R1762 T2208 T2210 aux has,shown
R1763 T2080 T2081 compound gene,regulation
R1764 T2209 T2210 auxpass been,shown
R1765 T2210 T2181 conj shown,known
R1766 T2211 T2213 aux to,associated
R1767 T2081 T2079 pobj regulation,of
R1768 T2082 T2081 prep in,regulation
R1769 T2212 T2213 auxpass be,associated
R1770 T2083 T2082 pobj mammals,in
R1771 T2213 T2210 xcomp associated,shown
R1772 T2214 T2213 prep with,associated
R1773 T2215 T2216 amod advanced,disease
R1774 T2084 T2081 cc and,regulation
R1775 T2085 T2087 det a,event
R1776 T2216 T2214 pobj disease,with
R1777 T2217 T2218 punct (,24
R1778 T2218 T2216 appos 24,disease
R1779 T2219 T2210 punct ),shown
R1780 T2220 T2181 punct .,known
R1781 T2221 T2231 nsubj Hypermethylation,remains
R1782 T2086 T2087 amod common,event
R1783 T2222 T2221 amod due,Hypermethylation
R1784 T2223 T2222 prep to,due
R1785 T2224 T2223 pobj overexpression,to
R1786 T2225 T2224 prep of,overexpression
R1787 T2087 T2075 appos event,one
R1788 T2226 T2227 compound DNA,methyltransferases
R1789 T2227 T2225 pobj methyltransferases,of
R1790 T2088 T2087 prep of,event
R1791 T2228 T2231 punct (,remains
R1792 T2229 T2231 nsubj DNMTs,remains
R1793 T2230 T2229 punct ),DNMTs
R1794 T2089 T2090 nsubj gene,silencing
R1795 T2231 T2231 ROOT remains,remains
R1796 T2232 T2234 nummod one,explanation
R1797 T2233 T2234 amod possible,explanation
R1798 T2090 T2088 pcomp silencing,of
R1799 T2234 T2231 attr explanation,remains
R1800 T2235 T2234 prep for,explanation
R1801 T2236 T2237 advmod de,novo
R1802 T2091 T2090 prep in,silencing
R1803 T2237 T2238 amod novo,methylation
R1804 T2238 T2235 pobj methylation,for
R1805 T2239 T2238 prep in,methylation
R1806 T2092 T2093 amod human,neoplasias
R1807 T2240 T2239 pobj tumorigenesis,in
R1808 T2093 T2091 pobj neoplasias,in
R1809 T2241 T2231 punct .,remains
R1810 T2242 T2247 advmod Recently,shown
R1811 T2094 T2093 punct (,neoplasias
R1812 T2243 T2247 punct ",",shown
R1813 T2244 T2247 nsubjpass DNMTs,shown
R1814 T2245 T2247 aux have,shown
R1815 T2095 T2093 appos "13,14",neoplasias
R1816 T2096 T2093 punct ),neoplasias
R1817 T2097 T2074 punct .,is
R1818 T2246 T2247 auxpass been,shown
R1819 T2098 T2099 mark As,opposed
R1820 T2247 T2247 ROOT shown,shown
R1821 T2248 T2249 aux to,be
R1822 T2249 T2247 xcomp be,shown
R1823 T2099 T2108 advcl opposed,is
R1824 T2250 T2249 acomp up-regulated,be
R1825 T2251 T2250 prep in,up-regulated
R1826 T2100 T2099 prep to,opposed
R1827 T2252 T2253 amod hematopoietic,malignancies
R1828 T2253 T2251 pobj malignancies,in
R1829 T2254 T2255 punct (,25
R1830 T2101 T2102 amod normal,cells
R1831 T2255 T2250 appos 25,up-regulated
R1832 T2256 T2247 punct ),shown
R1833 T2102 T2100 pobj cells,to
R1834 T2257 T2247 punct .,shown
R1835 T2258 T2258 ROOT Methyl-CpG-binding,Methyl-CpG-binding
R1836 T2259 T2258 dobj proteins,Methyl-CpG-binding
R1837 T2260 T2259 punct (,proteins
R1838 T2103 T2108 punct ",",is
R1839 T2261 T2259 appos MBPs,proteins
R1840 T2262 T2259 punct ),proteins
R1841 T2263 T2264 auxpass are,thought
R1842 T2104 T2108 nsubj hypermethylation,is
R1843 T2264 T2258 dep thought,Methyl-CpG-binding
R1844 T2265 T2266 aux to,inhibit
R1845 T2105 T2104 prep of,hypermethylation
R1846 T2266 T2264 xcomp inhibit,thought
R1847 T2267 T2268 det the,binding
R1848 T2268 T2266 dobj binding,inhibit
R1849 T2269 T2268 prep of,binding
R1850 T2106 T2107 compound CpG,islands
R1851 T2270 T2271 amod transcriptional,factors
R1852 T2271 T2269 pobj factors,of
R1853 T2107 T2105 pobj islands,of
R1854 T2272 T2266 prep to,inhibit
R1855 T2273 T2274 det the,promoter
R1856 T2274 T2272 pobj promoter,to
R1857 T2108 T2108 ROOT is,is
R1858 T2275 T2264 cc and,thought
R1859 T2276 T2278 auxpass are,discussed
R1860 T2277 T2278 advmod therefore,discussed
R1861 T2278 T2264 conj discussed,thought
R1862 T2279 T2278 prep as,discussed
R1863 T2280 T2281 nummod one,mechanism
R1864 T2109 T2112 det a,phenomenon
R1865 T2281 T2279 pobj mechanism,as
R1866 T2282 T2281 prep of,mechanism
R1867 T2283 T2284 compound transcription,inhibition
R1868 T2110 T2111 advmod frequently,observed
R1869 T2284 T2282 pobj inhibition,of
R1870 T2285 T2278 agent by,discussed
R1871 T2286 T2285 pobj hypermethylation,by
R1872 T2111 T2112 amod observed,phenomenon
R1873 T2287 T2288 punct (,26
R1874 T2288 T2286 parataxis 26,hypermethylation
R1875 T2289 T2288 punct ),26
R1876 T2290 T2258 punct .,Methyl-CpG-binding
R1877 T2112 T2108 attr phenomenon,is
R1878 T2291 T2296 prep In,studied
R1879 T2292 T2293 det this,work
R1880 T2113 T2112 prep in,phenomenon
R1881 T2293 T2291 pobj work,In
R1882 T2294 T2296 punct ",",studied
R1883 T2295 T2296 nsubj we,studied
R1884 T2114 T2116 det every,type
R1885 T2296 T2296 ROOT studied,studied
R1886 T2297 T2296 dobj mechanisms,studied
R1887 T2298 T2297 prep of,mechanisms
R1888 T2115 T2116 compound cancer,type
R1889 T2299 T2301 amod IRF-4,expression
R1890 T2300 T2301 compound gene,expression
R1891 T2301 T2298 pobj expression,of
R1892 T2116 T2113 pobj type,in
R1893 T2302 T2301 acl silencing,expression
R1894 T2303 T2302 prep in,silencing
R1895 T2304 T2305 amod leukemic,cells
R1896 T2117 T2108 punct .,is
R1897 T2305 T2303 pobj cells,in
R1898 T2306 T2296 punct .,studied
R1899 T2307 T2308 nsubj We,analyzed
R1900 T2118 T2120 compound De,DNA
R1901 T2308 T2308 ROOT analyzed,analyzed
R1902 T2309 T2312 det the,region
R1903 T2119 T2120 compound novo,DNA
R1904 T2310 T2312 amod IRF-4,region
R1905 T2311 T2312 compound promoter,region
R1906 T2312 T2308 dobj region,analyzed
R1907 T2120 T2121 compound DNA,methylation
R1908 T2313 T2308 prep for,analyzed
R1909 T2314 T2315 amod genetic,aberrations
R1910 T2315 T2313 pobj aberrations,for
R1911 T2316 T2315 cc and,aberrations
R1912 T2317 T2318 amod methylational,status
R1913 T2318 T2315 conj status,aberrations
R1914 T2121 T2139 nsubjpass methylation,thought
R1915 T2319 T2315 prep in,aberrations
R1916 T2320 T2319 pobj IRF-4-positive,in
R1917 T2321 T2308 cc and,analyzed
R1918 T2122 T2121 prep of,methylation
R1919 T2322 T2325 punct -,cells
R1920 T2323 T2325 amod negative,cells
R1921 T2324 T2325 amod hematopoietic,cells
R1922 T2123 T2122 pobj genes,of
R1923 T2325 T2308 conj cells,analyzed
R1924 T2124 T2125 amod such,as
R1925 T2326 T2308 punct .,analyzed
R1926 T2125 T2123 prep as,genes
R1927 T2126 T2127 compound cell,cycle
R1928 T2127 T2125 pobj cycle,as
R1929 T2128 T2121 punct ",",methylation
R1930 T2129 T2130 compound DNA,repair
R1931 T2130 T2121 conj repair,methylation
R1932 T2131 T2130 punct ",",repair
R1933 T2132 T2130 conj apoptosis,repair
R1934 T2133 T2132 cc and,apoptosis
R1935 T2134 T2136 compound tumor,genes
R1936 T2135 T2136 compound suppressor,genes
R1937 T2136 T2132 conj genes,apoptosis
R1938 T2137 T2139 auxpass is,thought
R1939 T2138 T2139 advmod therefore,thought
R1940 T2139 T2139 ROOT thought,thought
R1941 T2140 T2142 aux to,involved
R1942 T2141 T2142 auxpass be,involved
R1943 T2142 T2139 xcomp involved,thought
R1944 T2143 T2142 prep in,involved
R1945 T2144 T2143 pobj tumorigenesis,in
R1946 T2145 T2147 punct (,17
R1947 T2146 T2147 nummod 15,17
R1948 T2147 T2147 ROOT 17,17
R1949 T2148 T2147 punct ),17
R2193 T2774 T2775 compound Cell,lines
R2194 T2775 T2782 nsubjpass lines,obtained
R2195 T2776 T2782 nsubjpass K-562,obtained
R2196 T2777 T2776 punct ",",K-562
R2197 T2778 T2776 conj Jurkat,K-562
R2198 T2779 T2778 cc and,Jurkat
R2199 T2780 T2778 conj U-937,Jurkat
R2200 T2781 T2782 auxpass were,obtained
R2201 T2782 T2782 ROOT obtained,obtained
R2202 T2783 T2782 prep from,obtained
R2203 T2784 T2785 det the,ATCC
R2204 T2785 T2783 pobj ATCC,from
R2205 T2786 T2785 punct (,ATCC
R2206 T2787 T2790 compound American,Collection
R2207 T2788 T2790 compound Type,Collection
R2208 T2789 T2790 compound Culture,Collection
R2209 T2790 T2785 appos Collection,ATCC
R2210 T2791 T2790 punct ",",Collection
R2211 T2792 T2790 conj Rockville,Collection
R2212 T2793 T2792 punct ",",Rockville
R2213 T2794 T2792 conj USA,Rockville
R2214 T2795 T2792 punct ),Rockville
R2215 T2796 T2790 cc and,Collection
R2216 T2797 T2790 conj EM-2,Collection
R2217 T2798 T2797 punct ",",EM-2
R2218 T2799 T2797 conj LAMA-84,EM-2
R2219 T2800 T2799 punct ",",LAMA-84
R2220 T2801 T2799 conj CML-T1,LAMA-84
R2221 T2802 T2801 punct ",",CML-T1
R2222 T2803 T2801 conj BV-173,CML-T1
R2223 T2804 T2803 punct ",",BV-173
R2224 T2805 T2803 conj SD-1,BV-173
R2225 T2806 T2805 cc and,SD-1
R2226 T2807 T2805 conj RPMI-8226,SD-1
R2227 T2808 T2807 prep from,RPMI-8226
R2228 T2809 T2810 det the,DSMZ
R2229 T2810 T2808 pobj DSMZ,from
R2230 T2811 T2810 punct (,DSMZ
R2231 T2812 T2816 compound Deutsche,und
R2232 T2813 T2816 compound Sammlung,und
R2233 T2814 T2815 compound von,Mikroorganismen
R2234 T2815 T2816 compound Mikroorganismen,und
R2235 T2816 T2818 compound und,GmbH
R2236 T2817 T2818 compound Zellkulturen,GmbH
R2237 T2818 T2807 conj GmbH,RPMI-8226
R2238 T2819 T2818 punct ",",GmbH
R2239 T2820 T2818 conj Braunschweig,GmbH
R2240 T2821 T2820 punct ",",Braunschweig
R2241 T2822 T2820 conj Germany,Braunschweig
R2242 T2823 T2818 punct ),GmbH
R2243 T2824 T2782 punct .,obtained
R2244 T2825 T2827 det All,lines
R2245 T2826 T2827 compound cell,lines
R2246 T2827 T2836 nsubj lines,were
R2247 T2828 T2827 punct ",",lines
R2248 T2829 T2827 prep except,lines
R2249 T2830 T2829 pobj BV-173,except
R2250 T2831 T2830 punct ",",BV-173
R2251 T2832 T2830 conj SD-1,BV-173
R2252 T2833 T2832 cc and,SD-1
R2253 T2834 T2832 conj RPMI-8226,SD-1
R2254 T2835 T2836 punct ",",were
R2255 T2836 T2836 ROOT were,were
R2256 T2837 T2836 acomp IRF-4-negative,were
R2257 T2838 T2836 punct .,were
R2349 T2949 T2950 compound Cell,culture
R2350 T2950 T2957 nsubjpass culture,maintained
R2351 T2951 T2950 cc and,culture
R2352 T2952 T2950 conj stimulation,culture
R2353 T2953 T2955 det All,lines
R2354 T2954 T2955 compound cell,lines
R2355 T2955 T2957 nsubjpass lines,maintained
R2356 T2956 T2957 auxpass were,maintained
R2357 T2957 T2957 ROOT maintained,maintained
R2358 T2958 T2957 prep at,maintained
R2359 T2959 T2960 nummod 5,%
R2360 T2960 T2958 pobj %,at
R2361 T2961 T2960 nummod CO2,%
R2362 T2962 T2961 prep in,CO2
R2363 T2963 T2965 compound RPMI,medium
R2364 T2964 T2965 compound 1640,medium
R2365 T2965 T2962 pobj medium,in
R2366 T2966 T2957 prep with,maintained
R2367 T2967 T2968 nummod 1,%
R2368 T2968 T2969 compound %,glutamine
R2369 T2969 T2966 pobj glutamine,with
R2370 T2970 T2969 punct (,glutamine
R2371 T2971 T2972 compound Gibco/BRL,Eggenstein
R2372 T2972 T2969 appos Eggenstein,glutamine
R2373 T2973 T2972 punct ",",Eggenstein
R2374 T2974 T2972 appos Germany,Eggenstein
R2375 T2975 T2976 punct ),supplemented
R2376 T2976 T2957 advcl supplemented,maintained
R2377 T2977 T2976 prep with,supplemented
R2378 T2978 T2979 nummod 10,%
R2379 T2979 T2982 compound %,serum
R2380 T2980 T2981 amod fetal,calf
R2381 T2981 T2982 compound calf,serum
R2382 T2982 T2977 pobj serum,with
R2383 T2983 T2982 punct (,serum
R2384 T2984 T2982 appos Gibco/BRL,serum
R2385 T2985 T2982 punct ),serum
R2386 T2986 T2982 punct ",",serum
R2387 T2987 T2988 nummod 1,%
R2388 T2988 T2989 compound %,penicillin/streptomycin
R2389 T2989 T2982 appos penicillin/streptomycin,serum
R2390 T2990 T2991 punct (,Biochrom
R2391 T2991 T2989 appos Biochrom,penicillin/streptomycin
R2392 T2992 T2991 punct ",",Biochrom
R2393 T2993 T2991 conj Berlin,Biochrom
R2394 T2994 T2993 punct ",",Berlin
R2395 T2995 T2993 conj Germany,Berlin
R2396 T2996 T2991 punct ),Biochrom
R2397 T2997 T2957 punct .,maintained
R2398 T2998 T2999 advmod When,indicated
R2399 T2999 T3003 advcl indicated,treated
R2400 T3000 T3003 punct ",",treated
R2401 T3001 T3003 nsubjpass cells,treated
R2402 T3002 T3003 auxpass were,treated
R2403 T3003 T3003 ROOT treated,treated
R2404 T3004 T3003 prep with,treated
R2405 T3005 T3004 pobj 5-aza-2-deoxycytidine,with
R2406 T3006 T3005 punct (,5-aza-2-deoxycytidine
R2407 T3007 T3005 appos AzadC,5-aza-2-deoxycytidine
R2408 T3008 T3007 punct ),AzadC
R2409 T3009 T3005 cc or,5-aza-2-deoxycytidine
R2410 T3010 T3005 conj 5-azacytidine,5-aza-2-deoxycytidine
R2411 T3011 T3012 punct (,AzaC
R2412 T3012 T3010 appos AzaC,5-azacytidine
R2413 T3013 T3012 punct ),AzaC
R2414 T3014 T3015 punct (,Sigma
R2415 T3015 T3010 appos Sigma,5-azacytidine
R2416 T3016 T3015 punct ",",Sigma
R2417 T3017 T3015 conj Taufkirchen,Sigma
R2418 T3018 T3017 punct ",",Taufkirchen
R2419 T3019 T3017 conj Germany,Taufkirchen
R2420 T3020 T3003 punct ),treated
R2421 T3021 T3003 prep for,treated
R2422 T3022 T3024 amod different,periods
R2423 T3023 T3024 compound time,periods
R2424 T3024 T3021 pobj periods,for
R2425 T3025 T3003 punct .,treated
R2426 T3026 T3026 ROOT Owing,Owing
R2427 T3027 T3026 prep to,Owing
R2428 T3028 T3030 poss their,instability
R2429 T3029 T3030 compound chemical,instability
R2430 T3030 T3033 dep instability,were
R2431 T3031 T3032 amod fresh,substances
R2432 T3032 T3033 nsubj substances,were
R2433 T3033 T3026 aux were,Owing
R2434 T3034 T3037 advmod re-added,h.
R2435 T3035 T3037 det every,h.
R2436 T3036 T3037 nummod 24,h.
R2437 T3037 T3033 attr h.,were
R2561 T3192 T3192 ROOT Sequencing,Sequencing
R2562 T3193 T3192 prep of,Sequencing
R2563 T3194 T3196 det the,promoter
R2564 T3195 T3196 compound IRF-4,promoter
R2565 T3196 T3193 pobj promoter,of
R2566 T3197 T3214 prep For,PCR-amplified
R2567 T3198 T3197 pobj analysis,For
R2568 T3199 T3198 prep of,analysis
R2569 T3200 T3203 det the,region
R2570 T3201 T3203 amod IRF-4,region
R2571 T3202 T3203 compound promoter,region
R2572 T3203 T3199 pobj region,of
R2573 T3204 T3198 prep for,analysis
R2574 T3205 T3206 amod permanent,aberrations
R2575 T3206 T3204 pobj aberrations,for
R2576 T3207 T3208 amod such,as
R2577 T3208 T3206 prep as,aberrations
R2578 T3209 T3208 pobj insertions/deletions,as
R2579 T3210 T3209 cc or,insertions/deletions
R2580 T3211 T3209 conj mutation,insertions/deletions
R2581 T3212 T3214 punct ",",PCR-amplified
R2582 T3213 T3214 nsubj we,PCR-amplified
R2583 T3214 T3214 ROOT PCR-amplified,PCR-amplified
R2584 T3215 T3216 nummod two,fragments
R2585 T3216 T3214 dobj fragments,PCR-amplified
R2586 T3217 T3216 prep from,fragments
R2587 T3218 T3219 amod genomic,DNA
R2588 T3219 T3217 pobj DNA,from
R2589 T3220 T3219 punct ",",DNA
R2590 T3221 T3223 nsubjpass which,extracted
R2591 T3222 T3223 auxpass was,extracted
R2592 T3223 T3216 relcl extracted,fragments
R2593 T3224 T3223 prep from,extracted
R2594 T3225 T3227 amod depicted,lines
R2595 T3226 T3227 compound cell,lines
R2596 T3227 T3224 pobj lines,from
R2597 T3228 T3223 prep with,extracted
R2598 T3229 T3231 det a,kit
R2599 T3230 T3231 amod commercial,kit
R2600 T3231 T3228 pobj kit,with
R2601 T3232 T3231 punct (,kit
R2602 T3233 T3231 appos Qiagen,kit
R2603 T3234 T3233 punct ",",Qiagen
R2604 T3235 T3233 conj Hilde,Qiagen
R2605 T3236 T3235 punct ",",Hilde
R2606 T3237 T3235 appos Germany,Hilde
R2607 T3238 T3235 punct ),Hilde
R2608 T3239 T3240 mark as,recommended
R2609 T3240 T3223 advcl recommended,extracted
R2610 T3241 T3214 punct .,PCR-amplified
R2611 T3242 T3243 det The,primers
R2612 T3243 T3244 nsubj primers,were
R2613 T3244 T3244 ROOT were,were
R2614 T3245 T3244 acomp 1-forward,were
R2615 T3246 T3247 punct :,5
R2616 T3247 T3251 nummod 5,′
R2617 T3248 T3250 punct ′,TTGAGATGGAGTCTTGCTCTGT-3
R2618 T3249 T3250 punct -,TTGAGATGGAGTCTTGCTCTGT-3
R2619 T3250 T3251 compound TTGAGATGGAGTCTTGCTCTGT-3,′
R2620 T3251 T3275 dep ′,′
R2621 T3252 T3251 punct ",",′
R2622 T3253 T3275 dep 1-reverse,′
R2623 T3254 T3255 punct :,5
R2624 T3255 T3253 nummod 5,1-reverse
R2625 T3256 T3255 punct ′,5
R2626 T3257 T3258 punct -,CCAGGACCTCAGGAGGCCAGTCA-3
R2627 T3258 T3259 compound CCAGGACCTCAGGAGGCCAGTCA-3,′
R2628 T3259 T3255 dep ′,5
R2629 T3260 T3275 punct ;,′
R2630 T3261 T3275 amod 2-forward,′
R2631 T3262 T3267 punct :,′
R2632 T3263 T3267 nummod 5,′
R2633 T3264 T3266 punct ′,AGCGGTGAAACTGAGAGTGCGAGGT-3
R2634 T3265 T3266 punct -,AGCGGTGAAACTGAGAGTGCGAGGT-3
R2635 T3266 T3267 compound AGCGGTGAAACTGAGAGTGCGAGGT-3,′
R2636 T3267 T3275 nmod ′,′
R2637 T3268 T3267 punct ",",′
R2638 T3269 T3275 nmod 2-reverse,′
R2639 T3270 T3271 punct :,5
R2640 T3271 T3269 nummod 5,2-reverse
R2641 T3272 T3274 punct ′,GCCACATCGCTGCAGTTTAG-3
R2642 T3273 T3274 punct -,GCCACATCGCTGCAGTTTAG-3
R2643 T3274 T3275 compound GCCACATCGCTGCAGTTTAG-3,′
R2644 T3275 T3244 acomp ′,were
R2645 T3276 T3244 punct .,were
R2646 T3277 T3278 det The,products
R2647 T3278 T3280 nsubjpass products,cloned
R2648 T3279 T3280 auxpass were,cloned
R2649 T3280 T3280 ROOT cloned,cloned
R2650 T3281 T3280 prep with,cloned
R2651 T3282 T3286 det the,kit
R2652 T3283 T3284 compound TOPO,TA
R2653 T3284 T3285 nsubj TA,cloning
R2654 T3285 T3286 amod cloning,kit
R2655 T3286 T3281 pobj kit,with
R2656 T3287 T3286 punct (,kit
R2657 T3288 T3286 appos Invitrogen,kit
R2658 T3289 T3288 punct ",",Invitrogen
R2659 T3290 T3288 conj Groningen,Invitrogen
R2660 T3291 T3290 punct ",",Groningen
R2661 T3292 T3293 det The,Netherlands
R2662 T3293 T3290 appos Netherlands,Groningen
R2663 T3294 T3290 punct ),Groningen
R2664 T3295 T3280 punct .,cloned
R2665 T3296 T3316 prep After,sequenced
R2666 T3297 T3298 amod bacterial,amplification
R2667 T3298 T3296 pobj amplification,After
R2668 T3299 T3298 prep of,amplification
R2669 T3300 T3303 det the,fragments
R2670 T3301 T3303 amod cloned,fragments
R2671 T3302 T3303 compound PCR,fragments
R2672 T3303 T3299 pobj fragments,of
R2673 T3304 T3298 prep by,amplification
R2674 T3305 T3306 amod standard,procedures
R2675 T3306 T3304 pobj procedures,by
R2676 T3307 T3316 punct ",",sequenced
R2677 T3308 T3309 advmod at,least
R2678 T3309 T3310 advmod least,three
R2679 T3310 T3311 nummod three,clones
R2680 T3311 T3316 nsubjpass clones,sequenced
R2681 T3312 T3311 prep from,clones
R2682 T3313 T3314 det each,sample
R2683 T3314 T3312 pobj sample,from
R2684 T3315 T3316 auxpass were,sequenced
R2685 T3316 T3316 ROOT sequenced,sequenced
R2686 T3317 T3316 prep with,sequenced
R2687 T3318 T3320 det an,sequencer
R2688 T3319 T3320 amod automated,sequencer
R2689 T3320 T3317 pobj sequencer,with
R2690 T3321 T3320 punct (,sequencer
R2691 T3322 T3323 compound ABI,Prism
R2692 T3323 T3320 appos Prism,sequencer
R2693 T3324 T3323 nummod 377,Prism
R2694 T3325 T3323 punct ",",Prism
R2695 T3326 T3327 compound Applied,Bio-systems
R2696 T3327 T3323 appos Bio-systems,Prism
R2697 T3328 T3323 punct ",",Prism
R2698 T3329 T3330 compound Foster,City
R2699 T3330 T3323 appos City,Prism
R2700 T3331 T3330 punct ",",City
R2701 T3332 T3330 npadvmod USA,City
R2702 T3333 T3320 punct ),sequencer
R2703 T3334 T3335 mark as,recommended
R2704 T3335 T3316 advcl recommended,sequenced
R2705 T3336 T3335 agent by,recommended
R2706 T3337 T3338 det the,manufacturer
R2707 T3338 T3336 pobj manufacturer,by
R2708 T3339 T3316 punct .,sequenced
R3088 T3802 T3803 compound Expression,analysis
R3089 T3803 T3813 nsubjpass analysis,extracted
R3090 T3804 T3805 aux To,analyze
R3091 T3805 T3813 advcl analyze,extracted
R3092 T3806 T3809 det the,level
R3093 T3807 T3809 nmod IRF-4,level
R3094 T3808 T3809 amod transcriptional,level
R3095 T3809 T3805 dobj level,analyze
R3096 T3810 T3813 punct ",",extracted
R3097 T3811 T3813 nsubjpass RNA,extracted
R3098 T3812 T3813 auxpass was,extracted
R3099 T3813 T3813 ROOT extracted,extracted
R3100 T3814 T3813 prep from,extracted
R3101 T3815 T3814 pobj cells,from
R3102 T3816 T3813 advcl using,extracted
R3103 T3817 T3819 det the,RNAzol-kit
R3104 T3818 T3819 amod commercial,RNAzol-kit
R3105 T3819 T3816 dobj RNAzol-kit,using
R3106 T3820 T3819 punct (,RNAzol-kit
R3107 T3821 T3819 appos Paesel,RNAzol-kit
R3108 T3822 T3821 punct ",",Paesel
R3109 T3823 T3821 npadvmod Frankfurt,Paesel
R3110 T3824 T3823 punct ",",Frankfurt
R3111 T3825 T3823 conj Germany,Frankfurt
R3112 T3826 T3821 punct ),Paesel
R3113 T3827 T3813 punct .,extracted
R3114 T3828 T3829 det An,aliquot
R3115 T3829 T3836 nsubjpass aliquot,used
R3116 T3830 T3829 prep of,aliquot
R3117 T3831 T3832 nummod 1,μg
R3118 T3832 T3830 pobj μg,of
R3119 T3833 T3834 amod total,RNA
R3120 T3834 T3829 appos RNA,aliquot
R3121 T3835 T3836 auxpass was,used
R3122 T3836 T3836 ROOT used,used
R3123 T3837 T3836 prep for,used
R3124 T3838 T3839 compound cDNA,synthesis
R3125 T3839 T3837 pobj synthesis,for
R3126 T3840 T3841 mark as,described
R3127 T3841 T3836 advcl described,used
R3128 T3842 T3841 advmod previously,described
R3129 T3843 T3844 punct (,27
R3130 T3844 T3841 npadvmod 27,described
R3131 T3845 T3836 punct ),used
R3132 T3846 T3836 punct .,used
R3133 T3847 T3849 compound RNA,analysis
R3134 T3848 T3849 compound expression,analysis
R3135 T3849 T3858 nsubjpass analysis,carried
R3136 T3850 T3849 prep for,analysis
R3137 T3851 T3850 pobj IRF-4,for
R3138 T3852 T3851 cc and,IRF-4
R3139 T3853 T3855 det the,gene
R3140 T3854 T3855 compound reference,gene
R3141 T3855 T3856 compound gene,β-actin
R3142 T3856 T3858 nsubjpass β-actin,carried
R3143 T3857 T3858 auxpass was,carried
R3144 T3858 T3858 ROOT carried,carried
R3145 T3859 T3858 prt out,carried
R3146 T3860 T3858 agent by,carried
R3147 T3861 T3862 compound semi-quantitative,PCR
R3148 T3862 T3860 pobj PCR,by
R3149 T3863 T3864 mark as,described
R3150 T3864 T3858 advcl described,carried
R3151 T3865 T3864 advmod previously,described
R3152 T3866 T3864 punct (,described
R3153 T3867 T3864 npadvmod "3,27",described
R3154 T3868 T3864 punct ),described
R3155 T3869 T3858 punct .,carried
R3156 T3870 T3871 compound PCR,products
R3157 T3871 T3873 nsubjpass products,verified
R3158 T3872 T3873 auxpass were,verified
R3159 T3873 T3873 ROOT verified,verified
R3160 T3874 T3873 agent by,verified
R3161 T3875 T3876 amod automated,sequencing
R3162 T3876 T3874 pobj sequencing,by
R3163 T3877 T3873 punct .,verified
R3164 T3878 T3879 compound PCR,primers
R3165 T3879 T3904 nsubjpass primers,published
R3166 T3880 T3879 cc and,primers
R3167 T3881 T3879 conj conditions,primers
R3168 T3882 T3879 prep for,primers
R3169 T3883 T3884 compound expression,analysis
R3170 T3884 T3882 pobj analysis,for
R3171 T3885 T3884 prep of,analysis
R3172 T3886 T3885 pobj DNMT,of
R3173 T3887 T3886 cc or,DNMT
R3174 T3888 T3886 conj MBP,DNMT
R3175 T3889 T3888 punct (,MBP
R3176 T3890 T3891 compound DNMT1,DNMT3A
R3177 T3891 T3888 appos DNMT3A,MBP
R3178 T3892 T3891 punct ",",DNMT3A
R3179 T3893 T3891 conj DNMT3B,DNMT3A
R3180 T3894 T3893 punct ",",DNMT3B
R3181 T3895 T3893 conj MeCP,DNMT3B
R3182 T3896 T3895 punct ",",MeCP
R3183 T3897 T3895 conj MBD1,MeCP
R3184 T3898 T3897 punct ",",MBD1
R3185 T3899 T3897 conj MBD2,MBD1
R3186 T3900 T3899 cc and,MBD2
R3187 T3901 T3899 conj MBD4,MBD2
R3188 T3902 T3888 punct ),MBP
R3189 T3903 T3904 auxpass were,published
R3190 T3904 T3904 ROOT published,published
R3191 T3905 T3904 advmod elsewhere,published
R3192 T3906 T3904 punct (,published
R3193 T3907 T3904 npadvmod 28,published
R3194 T3908 T3904 punct ),published
R3195 T3909 T3904 punct .,published
R3196 T3910 T3922 prep For,performed
R3197 T3911 T3910 pobj analysis,For
R3198 T3912 T3911 prep of,analysis
R3199 T3913 T3915 compound IRF-4,expression
R3200 T3914 T3915 compound protein,expression
R3201 T3915 T3912 pobj expression,of
R3202 T3916 T3922 punct ",",performed
R3203 T3917 T3920 det a,assay
R3204 T3918 T3920 amod standard,assay
R3205 T3919 T3920 compound immunoblotting,assay
R3206 T3920 T3922 nsubjpass assay,performed
R3207 T3921 T3922 auxpass was,performed
R3208 T3922 T3922 ROOT performed,performed
R3209 T3923 T3924 mark as,described
R3210 T3924 T3922 advcl described,performed
R3211 T3925 T3924 advmod previously,described
R3212 T3926 T3927 punct (,29
R3213 T3927 T3924 npadvmod 29,described
R3214 T3928 T3922 punct ),performed
R3215 T3929 T3922 punct .,performed
R3216 T3930 T3935 advmod Briefly,generated
R3217 T3931 T3935 punct ",",generated
R3218 T3932 T3933 compound protein,lysates
R3219 T3933 T3935 nsubjpass lysates,generated
R3220 T3934 T3935 auxpass were,generated
R3221 T3935 T3935 ROOT generated,generated
R3222 T3936 T3935 prep by,generated
R3223 T3937 T3936 pcomp incubating,by
R3224 T3938 T3941 nummod 1,cells
R3225 T3939 T3941 nummod ×,cells
R3226 T3940 T3941 nummod 106,cells
R3227 T3941 T3937 dobj cells,incubating
R3228 T3942 T3937 prep in,incubating
R3229 T3943 T3944 nummod 100,µl
R3230 T3944 T3946 compound µl,buffer
R3231 T3945 T3946 compound RIPA,buffer
R3232 T3946 T3942 pobj buffer,in
R3233 T3947 T3950 punct (,NP-40
R3234 T3948 T3949 nummod 1,%
R3235 T3949 T3950 compound %,NP-40
R3236 T3950 T3946 appos NP-40,buffer
R3237 T3951 T3950 punct ",",NP-40
R3238 T3952 T3953 nummod 0.5,%
R3239 T3953 T3954 compound %,sodiumdesoxycholate
R3240 T3954 T3950 appos sodiumdesoxycholate,NP-40
R3241 T3955 T3954 punct ",",sodiumdesoxycholate
R3242 T3956 T3957 nummod 0.1,%
R3243 T3957 T3958 compound %,SDS
R3244 T3958 T3950 appos SDS,NP-40
R3245 T3959 T3958 punct ",",SDS
R3246 T3960 T3961 nummod 100,µg
R3247 T3961 T3965 nmod µg,fluoride
R3248 T3962 T3965 nmod /,fluoride
R3249 T3963 T3965 nmod ml,fluoride
R3250 T3964 T3965 compound phenylmethylsulfonyl,fluoride
R3251 T3965 T3958 appos fluoride,SDS
R3252 T3966 T3965 punct ",",fluoride
R3253 T3967 T3968 nummod 10,µl
R3254 T3968 T3971 nmod µl,protease-inhibitory-mix
R3255 T3969 T3971 nmod /,protease-inhibitory-mix
R3256 T3970 T3971 compound ml,protease-inhibitory-mix
R3257 T3971 T3965 conj protease-inhibitory-mix,fluoride
R3258 T3972 T3971 punct ",",protease-inhibitory-mix
R3259 T3973 T3975 quantmod 1,/
R3260 T3974 T3975 quantmod µmol,/
R3261 T3975 T3977 nummod /,sodiumorthovanadate
R3262 T3976 T3977 compound ml,sodiumorthovanadate
R3263 T3977 T3971 appos sodiumorthovanadate,protease-inhibitory-mix
R3264 T3978 T3977 prep in,sodiumorthovanadate
R3265 T3979 T3980 amod phosphate-buffered,saline
R3266 T3980 T3978 pobj saline,in
R3267 T3981 T3971 punct ),protease-inhibitory-mix
R3268 T3982 T3965 prep for,fluoride
R3269 T3983 T3984 nummod 30,min
R3270 T3984 T3982 pobj min,for
R3271 T3985 T3984 prep on,min
R3272 T3986 T3985 pobj ice,on
R3273 T3987 T3935 punct .,generated
R3274 T3988 T3997 prep After,determined
R3275 T3989 T3988 pobj centrifugation,After
R3276 T3990 T3997 punct ",",determined
R3277 T3991 T3992 compound protein,concentration
R3278 T3992 T3997 nsubjpass concentration,determined
R3279 T3993 T3992 prep of,concentration
R3280 T3994 T3995 det the,supernatant
R3281 T3995 T3993 pobj supernatant,of
R3282 T3996 T3997 auxpass was,determined
R3283 T3997 T3997 ROOT determined,determined
R3284 T3998 T3997 agent by,determined
R3285 T3999 T4001 amod BCA-method,Pierce
R3286 T4000 T4001 punct (,Pierce
R3287 T4001 T3998 pobj Pierce,by
R3288 T4002 T4001 punct ",",Pierce
R3289 T4003 T4006 nmod Rockford,)
R3290 T4004 T4003 punct ",",Rockford
R3291 T4005 T4003 conj IL,Rockford
R3292 T4006 T4001 punct ),Pierce
R3293 T4007 T4008 mark as,recommended
R3294 T4008 T4001 advcl recommended,Pierce
R3295 T4009 T3997 punct .,determined
R3296 T4010 T4011 compound Protein,lysates
R3297 T4011 T4018 nsubjpass lysates,electrophoresed
R3298 T4012 T4011 punct (,lysates
R3299 T4013 T4011 appos 70,lysates
R3300 T4014 T4015 nummod 100,µg
R3301 T4015 T4013 appos µg,70
R3302 T4016 T4013 punct ),70
R3303 T4017 T4018 auxpass were,electrophoresed
R3304 T4018 T4018 ROOT electrophoresed,electrophoresed
R3305 T4019 T4018 prep on,electrophoresed
R3306 T4020 T4021 compound polyacrylamide,gels
R3307 T4021 T4019 pobj gels,on
R3308 T4022 T4018 cc and,electrophoresed
R3309 T4023 T4018 conj transferred,electrophoresed
R3310 T4024 T4023 prep to,transferred
R3311 T4025 T4026 det a,PVDF-membrane
R3312 T4026 T4024 pobj PVDF-membrane,to
R3313 T4027 T4029 punct (,P
R3314 T4028 T4029 compound Immobilon,P
R3315 T4029 T4026 appos P,PVDF-membrane
R3316 T4030 T4029 punct ",",P
R3317 T4031 T4032 nummod 0.45,µm
R3318 T4032 T4029 appos µm,P
R3319 T4033 T4029 punct ;,P
R3320 T4034 T4029 conj Millipore,P
R3321 T4035 T4034 punct ",",Millipore
R3322 T4036 T4034 conj Eschborn,Millipore
R3323 T4037 T4036 punct ",",Eschborn
R3324 T4038 T4036 conj Germany,Eschborn
R3325 T4039 T4029 punct ),P
R3326 T4040 T4018 punct .,electrophoresed
R3327 T4041 T4043 nsubjpass Membranes,blocked
R3328 T4042 T4043 auxpass were,blocked
R3329 T4043 T4043 ROOT blocked,blocked
R3330 T4044 T4043 prep with,blocked
R3331 T4045 T4046 nummod 2.5,%
R3332 T4046 T4047 nsubj %,blocking
R3333 T4047 T4044 pcomp blocking,with
R3334 T4048 T4047 dobj reagent,blocking
R3335 T4049 T4051 punct (,Mannheim
R3336 T4050 T4051 compound Boehringer,Mannheim
R3337 T4051 T4086 nsubj Mannheim,incubated
R3338 T4052 T4051 punct ",",Mannheim
R3339 T4053 T4051 npadvmod Germany,Mannheim
R3340 T4054 T4051 punct ),Mannheim
R3341 T4055 T4051 prep in,Mannheim
R3342 T4056 T4057 compound TBST,buffer
R3343 T4057 T4055 pobj buffer,in
R3344 T4058 T4051 punct (,Mannheim
R3345 T4059 T4060 nummod 4.44,g/l
R3346 T4060 T4061 compound g/l,Tris
R3347 T4061 T4051 appos Tris,Mannheim
R3348 T4062 T4051 appos HCL,Mannheim
R3349 T4063 T4062 punct ",",HCL
R3350 T4064 T4065 nummod 2.65,g/l
R3351 T4065 T4066 compound g/l,TrisOH
R3352 T4066 T4051 appos TrisOH,Mannheim
R3353 T4067 T4051 punct ",",Mannheim
R3354 T4068 T4069 nummod 8.07,g/l
R3355 T4069 T4070 compound g/l,NaCl
R3356 T4070 T4051 appos NaCl,Mannheim
R3357 T4071 T4070 punct ",",NaCl
R3358 T4072 T4073 nummod 0.2,g/l
R3359 T4073 T4074 compound g/l,KCl
R3360 T4074 T4070 conj KCl,NaCl
R3361 T4075 T4074 cc and,KCl
R3362 T4076 T4077 nummod 500,µl
R3363 T4077 T4078 compound µl,/
R3364 T4078 T4080 compound /,Tween-20
R3365 T4079 T4080 compound l,Tween-20
R3366 T4080 T4074 conj Tween-20,KCl
R3367 T4081 T4080 prep in,Tween-20
R3368 T4082 T4081 pobj H2O,in
R3369 T4083 T4080 punct ),Tween-20
R3370 T4084 T4080 cc and,Tween-20
R3371 T4085 T4086 advmod subsequently,incubated
R3372 T4086 T4047 advcl incubated,blocking
R3373 T4087 T4086 prep with,incubated
R3374 T4088 T4089 amod primary,antibody
R3375 T4089 T4087 pobj antibody,with
R3376 T4090 T4091 mark as,indicated
R3377 T4091 T4086 advcl indicated,incubated
R3378 T4092 T4091 cc and,indicated
R3379 T4093 T4096 amod horseradish,antibody
R3380 T4094 T4096 amod peroxidase-conjugated,antibody
R3381 T4095 T4096 amod secondary,antibody
R3382 T4096 T4103 nmod antibody,DAKO
R3383 T4097 T4096 punct ",",antibody
R3384 T4098 T4096 conj anti-mouse,antibody
R3385 T4099 T4098 cc or,anti-mouse
R3386 T4100 T4098 conj anti-goat,anti-mouse
R3387 T4101 T4103 nmod IgG,DAKO
R3388 T4102 T4103 punct (,DAKO
R3389 T4103 T4086 conj DAKO,incubated
R3390 T4104 T4103 punct ",",DAKO
R3391 T4105 T4103 conj Hamburg,DAKO
R3392 T4106 T4105 punct ",",Hamburg
R3393 T4107 T4105 conj Germany,Hamburg
R3394 T4108 T4105 punct ),Hamburg
R3395 T4109 T4103 punct ",",DAKO
R3396 T4110 T4103 npadvmod respectively,DAKO
R3397 T4111 T4043 punct .,blocked
R3398 T4112 T4113 det The,membranes
R3399 T4113 T4116 nsubjpass membranes,developed
R3400 T4114 T4116 auxpass were,developed
R3401 T4115 T4116 advmod then,developed
R3402 T4116 T4116 ROOT developed,developed
R3403 T4117 T4116 prep with,developed
R3404 T4118 T4121 det an,kit
R3405 T4119 T4121 compound ECL,kit
R3406 T4120 T4121 compound detection,kit
R3407 T4121 T4117 pobj kit,with
R3408 T4122 T4121 punct (,kit
R3409 T4123 T4125 compound Amersham,Biotech
R3410 T4124 T4125 compound Pharmacia,Biotech
R3411 T4125 T4121 appos Biotech,kit
R3412 T4126 T4125 punct ",",Biotech
R3413 T4127 T4125 conj Freiburg,Biotech
R3414 T4128 T4127 punct ",",Freiburg
R3415 T4129 T4127 appos Germany,Freiburg
R3416 T4130 T4127 punct ),Freiburg
R3417 T4131 T4116 punct .,developed
R3418 T4132 T4134 det The,antibodies
R3419 T4133 T4134 amod primary,antibodies
R3420 T4134 T4135 nsubj antibodies,were
R3421 T4135 T4135 ROOT were,were
R3422 T4136 T4139 amod goat,ICSAT
R3423 T4137 T4139 amod anti-IRF-4,ICSAT
R3424 T4138 T4139 compound /,ICSAT
R3425 T4139 T4135 attr ICSAT,were
R3426 T4140 T4139 punct (,ICSAT
R3427 T4141 T4139 appos M-17,ICSAT
R3428 T4142 T4139 punct ),ICSAT
R3429 T4143 T4146 punct (,Biotechnology
R3430 T4144 T4145 compound Santa,Cruz
R3431 T4145 T4146 compound Cruz,Biotechnology
R3432 T4146 T4139 conj Biotechnology,ICSAT
R3433 T4147 T4146 punct ",",Biotechnology
R3434 T4148 T4149 compound Santa,Cruz
R3435 T4149 T4146 conj Cruz,Biotechnology
R3436 T4150 T4149 punct ",",Cruz
R3437 T4151 T4149 conj CA,Cruz
R3438 T4152 T4146 punct ),Biotechnology
R3439 T4153 T4146 cc and,Biotechnology
R3440 T4154 T4155 compound mouse,anti-β-actin
R3441 T4155 T4139 conj anti-β-actin,ICSAT
R3442 T4156 T4157 punct (,AC-74
R3443 T4157 T4155 appos AC-74,anti-β-actin
R3444 T4158 T4155 punct ),anti-β-actin
R3445 T4159 T4160 punct (,Sigma
R3446 T4160 T4139 appos Sigma,ICSAT
R3447 T4161 T4139 punct ),ICSAT
R3448 T4162 T4135 punct .,were
R3780 T4626 T4628 amod Methylation-specific,DNA
R3781 T4627 T4628 amod restriction-PCR-assay,DNA
R3782 T4628 T4630 nsubjpass DNA,extracted
R3783 T4629 T4630 auxpass was,extracted
R3784 T4630 T4630 ROOT extracted,extracted
R3785 T4631 T4630 prep with,extracted
R3786 T4632 T4634 det a,kit
R3787 T4633 T4634 amod commercial,kit
R3788 T4634 T4631 pobj kit,with
R3789 T4635 T4634 punct (,kit
R3790 T4636 T4634 appos Qiagen,kit
R3791 T4637 T4634 punct ),kit
R3792 T4638 T4639 mark as,recommended
R3793 T4639 T4630 advcl recommended,extracted
R3794 T4640 T4630 punct .,extracted
R3795 T4641 T4649 mark Since,inhibited
R3796 T4642 T4644 det the,ability
R3797 T4643 T4644 compound restriction,ability
R3798 T4644 T4649 nsubjpass ability,inhibited
R3799 T4645 T4644 prep of,ability
R3800 T4646 T4647 amod several,endonucleases
R3801 T4647 T4645 pobj endonucleases,of
R3802 T4648 T4649 auxpass is,inhibited
R3803 T4649 T4658 advcl inhibited,used
R3804 T4650 T4649 agent by,inhibited
R3805 T4651 T4650 pobj methylation,by
R3806 T4652 T4651 prep of,methylation
R3807 T4653 T4655 poss their,sequence
R3808 T4654 T4655 compound target,sequence
R3809 T4655 T4652 pobj sequence,of
R3810 T4656 T4658 punct ",",used
R3811 T4657 T4658 nsubj we,used
R3812 T4658 T4658 ROOT used,used
R3813 T4659 T4660 amod methylation-sensitive,enzymes
R3814 T4660 T4658 dobj enzymes,used
R3815 T4661 T4660 appos HpaII,enzymes
R3816 T4662 T4661 cc and,HpaII
R3817 T4663 T4664 compound HaeII-isochizomer,Bsp143II
R3818 T4664 T4661 conj Bsp143II,HpaII
R3819 T4665 T4664 cc and,Bsp143II
R3820 T4666 T4664 conj Bsh1236I,Bsp143II
R3821 T4667 T4669 punct (,Fermentas
R3822 T4668 T4669 compound MBI,Fermentas
R3823 T4669 T4664 conj Fermentas,Bsp143II
R3824 T4670 T4669 punct ",",Fermentas
R3825 T4671 T4672 compound St,Leon-Rot
R3826 T4672 T4669 conj Leon-Rot,Fermentas
R3827 T4673 T4672 punct ",",Leon-Rot
R3828 T4674 T4672 appos Germany,Leon-Rot
R3829 T4675 T4672 punct ),Leon-Rot
R3830 T4676 T4677 punct (,"20,24"
R3831 T4677 T4672 appos "20,24",Leon-Rot
R3832 T4678 T4677 punct ),"20,24"
R3833 T4679 T4658 punct .,used
R3834 T4680 T4701 prep As,used
R3835 T4681 T4680 pobj control,As
R3836 T4682 T4684 det the,enzyme
R3837 T4683 T4684 compound methylation-resistant,enzyme
R3838 T4684 T4701 nsubjpass enzyme,used
R3839 T4685 T4684 appos MspI,enzyme
R3840 T4686 T4685 cc and,MspI
R3841 T4687 T4688 det an,enzyme
R3842 T4688 T4685 conj enzyme,MspI
R3843 T4689 T4688 prep with,enzyme
R3844 T4690 T4692 det no,site
R3845 T4691 T4692 compound recognition,site
R3846 T4692 T4689 pobj site,with
R3847 T4693 T4692 prep in,site
R3848 T4694 T4696 det the,promoter
R3849 T4695 T4696 compound target,promoter
R3850 T4696 T4693 pobj promoter,in
R3851 T4697 T4696 punct ",",promoter
R3852 T4698 T4696 appos EcoRI,promoter
R3853 T4699 T4701 punct ",",used
R3854 T4700 T4701 auxpass were,used
R3855 T4701 T4701 ROOT used,used
R3856 T4702 T4701 punct .,used
R3857 T4703 T4709 nsubjpass DNA,digested
R3858 T4704 T4706 punct (,µg
R3859 T4705 T4706 nummod 0.8,µg
R3860 T4706 T4703 appos µg,DNA
R3861 T4707 T4706 punct ),µg
R3862 T4708 T4709 auxpass was,digested
R3863 T4709 T4709 ROOT digested,digested
R3864 T4710 T4709 agent by,digested
R3865 T4711 T4715 nummod 40,enzyme
R3866 T4712 T4715 nmod U,enzyme
R3867 T4713 T4715 det the,enzyme
R3868 T4714 T4715 amod respective,enzyme
R3869 T4715 T4710 pobj enzyme,by
R3870 T4716 T4709 prep for,digested
R3871 T4717 T4718 nummod 6,h
R3872 T4718 T4716 pobj h,for
R3873 T4719 T4718 cc and,h
R3874 T4720 T4718 punct ",",h
R3875 T4721 T4722 aux to,ensure
R3876 T4722 T4709 advcl ensure,digested
R3877 T4723 T4724 amod complete,cleavage
R3878 T4724 T4722 dobj cleavage,ensure
R3879 T4725 T4724 punct ",",cleavage
R3880 T4726 T4728 amod additional,U
R3881 T4727 T4728 nummod 20,U
R3882 T4728 T4724 appos U,cleavage
R3883 T4729 T4722 prep for,ensure
R3884 T4730 T4731 nummod 16,h.
R3885 T4731 T4729 pobj h.,for
R3886 T4732 T4739 advmod Thereafter,used
R3887 T4733 T4734 nummod 100,ng
R3888 T4734 T4739 nsubjpass ng,used
R3889 T4735 T4734 prep of,ng
R3890 T4736 T4737 amod digested,DNA
R3891 T4737 T4735 pobj DNA,of
R3892 T4738 T4739 auxpass was,used
R3893 T4739 T4739 ROOT used,used
R3894 T4740 T4739 prep to,used
R3895 T4741 T4743 det a,amplification
R3896 T4742 T4743 compound PCR,amplification
R3897 T4743 T4740 pobj amplification,to
R3898 T4744 T4743 prep of,amplification
R3899 T4745 T4746 nummod two,fragments
R3900 T4746 T4744 pobj fragments,of
R3901 T4747 T4746 punct (,fragments
R3902 T4748 T4746 appos F1,fragments
R3903 T4749 T4748 cc and,F1
R3904 T4750 T4748 conj F2,F1
R3905 T4751 T4746 punct ),fragments
R3906 T4752 T4743 acl spanning,amplification
R3907 T4753 T4752 dobj part,spanning
R3908 T4754 T4753 prep of,part
R3909 T4755 T4757 det the,promoter
R3910 T4756 T4757 compound IRF-4,promoter
R3911 T4757 T4754 pobj promoter,of
R3912 T4758 T4757 punct (,promoter
R3913 T4759 T4757 appos 30,promoter
R3914 T4760 T4757 punct ),promoter
R3915 T4761 T4763 punct (,U52683
R3916 T4762 T4763 compound GenBank,U52683
R3917 T4763 T4743 appos U52683,amplification
R3918 T4764 T4765 punct ;,see
R3919 T4765 T4765 ROOT see,see
R3920 T4766 T4767 compound Figure,3A
R3921 T4767 T4765 dobj 3A,see
R3922 T4768 T4765 punct ),see
R3923 T4769 T4765 punct .,see
R3924 T4770 T4771 det The,sequences
R3925 T4771 T4775 nsubj sequences,were
R3926 T4772 T4771 prep of,sequences
R3927 T4773 T4774 det the,primers
R3928 T4774 T4772 pobj primers,of
R3929 T4775 T4775 ROOT were,were
R3930 T4776 T4775 acomp F1-forward,were
R3931 T4777 T4775 punct :,were
R3932 T4778 T4782 nummod 5,′
R3933 T4779 T4781 punct ′,TTGAGATGGAGTCTTGCTCTGT-3
R3934 T4780 T4781 punct -,TTGAGATGGAGTCTTGCTCTGT-3
R3935 T4781 T4782 compound TTGAGATGGAGTCTTGCTCTGT-3,′
R3936 T4782 T4793 npadvmod ′,F2-forward
R3937 T4783 T4784 punct ",",F1-reverse
R3938 T4784 T4793 nmod F1-reverse,F2-forward
R3939 T4785 T4784 punct :,F1-reverse
R3940 T4786 T4787 compound ATCACTTCCAGACTTCAGTTCACCT-3,′
R3941 T4787 T4784 appos ′,F1-reverse
R3942 T4788 T4790 punct (,bp
R3943 T4789 T4790 nummod 341,bp
R3944 T4790 T4787 appos bp,′
R3945 T4791 T4787 punct ),′
R3946 T4792 T4793 punct ;,F2-forward
R3947 T4793 T4775 dep F2-forward,were
R3948 T4794 T4793 punct :,F2-forward
R3949 T4795 T4799 nummod 5,′
R3950 T4796 T4798 punct ′,AAGGTGAACTGAAGTCTGGAAGTGA-3
R3951 T4797 T4798 punct -,AAGGTGAACTGAAGTCTGGAAGTGA-3
R3952 T4798 T4799 compound AAGGTGAACTGAAGTCTGGAAGTGA-3,′
R3953 T4799 T4793 appos ′,F2-forward
R3954 T4800 T4799 punct ",",′
R3955 T4801 T4799 conj F2-reverse,′
R3956 T4802 T4801 punct :,F2-reverse
R3957 T4803 T4807 nummod 5,′
R3958 T4804 T4806 punct ′,CCAGGACCTCAGGAGGCCAGTCA-3
R3959 T4805 T4806 punct -,CCAGGACCTCAGGAGGCCAGTCA-3
R3960 T4806 T4807 compound CCAGGACCTCAGGAGGCCAGTCA-3,′
R3961 T4807 T4801 appos ′,F2-reverse
R3962 T4808 T4810 punct (,bp
R3963 T4809 T4810 nummod 474,bp
R3964 T4810 T4807 appos bp,′
R3965 T4811 T4807 punct ),′
R3966 T4812 T4775 punct .,were
R3967 T4813 T4815 det The,conditions
R3968 T4814 T4815 compound PCR,conditions
R3969 T4815 T4817 nsubjpass conditions,described
R3970 T4816 T4817 auxpass were,described
R3971 T4817 T4817 ROOT described,described
R3972 T4818 T4817 advmod elsewhere,described
R3973 T4819 T4820 punct (,3
R3974 T4820 T4817 parataxis 3,described
R3975 T4821 T4820 punct ),3
R3976 T4822 T4817 punct .,described
R3977 T4823 T4825 nsubjpass PCR,performed
R3978 T4824 T4825 auxpass was,performed
R3979 T4825 T4825 ROOT performed,performed
R3980 T4826 T4825 prep with,performed
R3981 T4827 T4829 det an,temperature
R3982 T4828 T4829 compound annealing,temperature
R3983 T4829 T4826 pobj temperature,with
R3984 T4830 T4829 prep of,temperature
R3985 T4831 T4833 nummod 62,C
R3986 T4832 T4833 nummod °,C
R3987 T4833 T4830 pobj C,of
R3988 T4834 T4829 cc and,temperature
R3989 T4835 T4836 nummod 35,cycles
R3990 T4836 T4829 conj cycles,temperature
R3991 T4837 T4825 punct .,performed
R3992 T4838 T4841 advmod When,methylated
R3993 T4839 T4841 nsubjpass DNA,methylated
R3994 T4840 T4841 auxpass was,methylated
R3995 T4841 T4849 advcl methylated,were
R3996 T4842 T4841 prep at,methylated
R3997 T4843 T4844 amod specific,sites
R3998 T4844 T4842 pobj sites,at
R3999 T4845 T4849 punct ",",were
R4000 T4846 T4848 det the,enzymes
R4001 T4847 T4848 amod sensitive,enzymes
R4002 T4848 T4849 nsubj enzymes,were
R4003 T4849 T4869 ccomp were,digested
R4004 T4850 T4849 neg not,were
R4005 T4851 T4849 acomp able,were
R4006 T4852 T4853 aux to,digest
R4007 T4853 T4851 xcomp digest,able
R4008 T4854 T4855 det the,DNA
R4009 T4855 T4853 dobj DNA,digest
R4010 T4856 T4855 cc and,DNA
R4011 T4857 T4855 conj amplification,DNA
R4012 T4858 T4849 conj took,were
R4013 T4859 T4858 dobj place,took
R4014 T4860 T4869 punct ;,digested
R4015 T4861 T4869 prep in,digested
R4016 T4862 T4861 pobj case,in
R4017 T4863 T4862 prep of,case
R4018 T4864 T4865 det no,methylation
R4019 T4865 T4863 pobj methylation,of
R4020 T4866 T4869 punct ",",digested
R4021 T4867 T4869 nsubjpass DNA,digested
R4022 T4868 T4869 auxpass was,digested
R4023 T4869 T4869 ROOT digested,digested
R4024 T4870 T4869 cc and,digested
R4025 T4871 T4872 det no,product
R4026 T4872 T4874 nsubjpass product,generated
R4027 T4873 T4874 auxpass was,generated
R4028 T4874 T4869 conj generated,digested
R4029 T4875 T4874 punct .,generated
R4030 T4876 T4878 det The,products
R4031 T4877 T4878 compound PCR,products
R4032 T4878 T4880 nsubjpass products,electrophoresed
R4033 T4879 T4880 auxpass were,electrophoresed
R4034 T4880 T4880 ROOT electrophoresed,electrophoresed
R4035 T4881 T4880 prep on,electrophoresed
R4036 T4882 T4886 det a,gel
R4037 T4883 T4884 nummod 3,%
R4038 T4884 T4886 nmod %,gel
R4039 T4885 T4886 amod agarose,gel
R4040 T4886 T4881 pobj gel,on
R4041 T4887 T4889 punct ",",stained
R4042 T4888 T4889 auxpass were,stained
R4043 T4889 T4880 conj stained,electrophoresed
R4044 T4890 T4889 prep with,stained
R4045 T4891 T4892 compound ethidium,bromide
R4046 T4892 T4890 pobj bromide,with
R4047 T4893 T4889 cc and,stained
R4048 T4894 T4889 conj photographed,stained
R4049 T4895 T4889 punct .,stained
R4050 T4896 T4897 compound PCR,products
R4051 T4897 T4899 nsubjpass products,verified
R4052 T4898 T4899 auxpass were,verified
R4053 T4899 T4899 ROOT verified,verified
R4054 T4900 T4899 agent by,verified
R4055 T4901 T4902 amod automated,sequencing
R4056 T4902 T4900 pobj sequencing,by
R4057 T4903 T4899 punct .,verified
R4386 T5272 T5274 compound Bisulfite,DNA
R4387 T5273 T5274 compound treatment,DNA
R4388 T5274 T5276 nsubjpass DNA,extracted
R4389 T5275 T5276 auxpass was,extracted
R4390 T5276 T5276 ROOT extracted,extracted
R4391 T5277 T5278 mark as,described
R4392 T5278 T5276 advcl described,extracted
R4393 T5279 T5278 advmod above,described
R4394 T5280 T5276 punct .,extracted
R4395 T5281 T5282 amod Bisulfite,treatment
R4396 T5282 T5304 advcl treatment,performed
R4397 T5283 T5282 prep of,treatment
R4398 T5284 T5283 pobj DNA,of
R4399 T5285 T5282 punct ",",treatment
R4400 T5286 T5304 advcl leading,performed
R4401 T5287 T5286 prep to,leading
R4402 T5288 T5287 pobj conversion,to
R4403 T5289 T5288 prep of,conversion
R4404 T5290 T5291 amod unmethylated,cytosine
R4405 T5291 T5289 pobj cytosine,of
R4406 T5292 T5293 aux to,uracil
R4407 T5293 T5286 xcomp uracil,leading
R4408 T5294 T5293 dobj residues,uracil
R4409 T5295 T5294 cc and,residues
R4410 T5296 T5297 det no,change
R4411 T5297 T5293 dobj change,uracil
R4412 T5298 T5297 prep of,change
R4413 T5299 T5301 amod methylated,residues
R4414 T5300 T5301 compound cytosine,residues
R4415 T5301 T5298 pobj residues,of
R4416 T5302 T5304 punct ",",performed
R4417 T5303 T5304 auxpass was,performed
R4418 T5304 T5304 ROOT performed,performed
R4419 T5305 T5306 advmod as,described
R4420 T5306 T5304 advcl described,performed
R4421 T5307 T5308 mark as,follows
R4422 T5308 T5304 advcl follows,performed
R4423 T5309 T5304 punct .,performed
R4424 T5310 T5338 advmod Briefly,denaturated
R4425 T5311 T5338 punct ",",denaturated
R4426 T5312 T5313 nummod 1,µg
R4427 T5313 T5338 nsubjpass µg,denaturated
R4428 T5314 T5313 prep of,µg
R4429 T5315 T5314 pobj DNA,of
R4430 T5316 T5313 cc and,µg
R4431 T5317 T5318 nummod 2,µg
R4432 T5318 T5313 conj µg,µg
R4433 T5319 T5318 prep of,µg
R4434 T5320 T5319 pobj poly,of
R4435 T5321 T5322 punct (,dA
R4436 T5322 T5318 appos dA,µg
R4437 T5323 T5322 appos dT,dA
R4438 T5324 T5322 punct ),dA
R4439 T5325 T5328 punct (,dA
R4440 T5326 T5328 nmod poly,dA
R4441 T5327 T5328 punct (,dA
R4442 T5328 T5322 appos dA,dA
R4443 T5329 T5322 appos dT,dA
R4444 T5330 T5322 punct ),dA
R4445 T5331 T5318 conj copolymers,µg
R4446 T5332 T5331 punct (,copolymers
R4447 T5333 T5335 compound Amersham,Biotech
R4448 T5334 T5335 compound Pharmacia,Biotech
R4449 T5335 T5331 appos Biotech,copolymers
R4450 T5336 T5331 punct ),copolymers
R4451 T5337 T5338 auxpass were,denaturated
R4452 T5338 T5338 ROOT denaturated,denaturated
R4453 T5339 T5338 prep for,denaturated
R4454 T5340 T5341 nummod 20,min
R4455 T5341 T5339 pobj min,for
R4456 T5342 T5338 prep at,denaturated
R4457 T5343 T5344 nummod 42,°
R4458 T5344 T5345 nummod °,C
R4459 T5345 T5342 pobj C,at
R4460 T5346 T5338 prep in,denaturated
R4461 T5347 T5349 nummod 0.3,NaOH
R4462 T5348 T5349 compound M,NaOH
R4463 T5349 T5346 pobj NaOH,in
R4464 T5350 T5338 prep in,denaturated
R4465 T5351 T5352 det a,volume
R4466 T5352 T5350 pobj volume,in
R4467 T5353 T5352 prep of,volume
R4468 T5354 T5355 nummod 50,µl
R4469 T5355 T5353 pobj µl,of
R4470 T5356 T5338 punct .,denaturated
R4471 T5357 T5358 amod Fresh,solutions
R4472 T5358 T5384 nsubjpass solutions,added
R4473 T5359 T5358 prep of,solutions
R4474 T5360 T5361 nummod 30,µl
R4475 T5361 T5359 pobj µl,of
R4476 T5362 T5361 prep of,µl
R4477 T5363 T5365 nummod 10,hydrochinon
R4478 T5364 T5365 compound mM,hydrochinon
R4479 T5365 T5362 pobj hydrochinon,of
R4480 T5366 T5367 punct (,Sigma
R4481 T5367 T5365 appos Sigma,hydrochinon
R4482 T5368 T5367 punct ),Sigma
R4483 T5369 T5365 cc and,hydrochinon
R4484 T5370 T5371 nummod 530,µl
R4485 T5371 T5361 appos µl,µl
R4486 T5372 T5371 prep of,µl
R4487 T5373 T5376 nummod 3,bisulfite
R4488 T5374 T5375 compound M,sodium
R4489 T5375 T5376 compound sodium,bisulfite
R4490 T5376 T5372 pobj bisulfite,of
R4491 T5377 T5376 punct (,bisulfite
R4492 T5378 T5376 appos pH,bisulfite
R4493 T5379 T5378 nummod 5.0,pH
R4494 T5380 T5358 punct ;,solutions
R4495 T5381 T5358 appos Sigma,solutions
R4496 T5382 T5358 punct ),solutions
R4497 T5383 T5384 auxpass were,added
R4498 T5384 T5384 ROOT added,added
R4499 T5385 T5384 punct ",",added
R4500 T5386 T5387 det the,solution
R4501 T5387 T5388 nsubj solution,was
R4502 T5388 T5384 conj was,added
R4503 T5389 T5390 advmod gently,mixed
R4504 T5390 T5388 acomp mixed,was
R4505 T5391 T5388 punct ",",was
R4506 T5392 T5388 prep overlayed,was
R4507 T5393 T5392 prep with,overlayed
R4508 T5394 T5395 compound mineral,oil
R4509 T5395 T5393 pobj oil,with
R4510 T5396 T5392 cc and,overlayed
R4511 T5397 T5392 conj incubated,overlayed
R4512 T5398 T5397 prep in,incubated
R4513 T5399 T5400 det the,dark
R4514 T5400 T5398 pobj dark,in
R4515 T5401 T5397 prep for,incubated
R4516 T5402 T5401 pobj 12,for
R4517 T5403 T5404 nummod 13,h
R4518 T5404 T5402 appos h,12
R4519 T5405 T5404 prep at,h
R4520 T5406 T5407 nummod 50,°
R4521 T5407 T5405 pobj °,at
R4522 T5408 T5404 npadvmod C,h
R4523 T5409 T5388 punct .,was
R4524 T5410 T5412 det The,phase
R4525 T5411 T5412 amod aqueous,phase
R4526 T5412 T5414 nsubjpass phase,recovered
R4527 T5413 T5414 auxpass was,recovered
R4528 T5414 T5414 ROOT recovered,recovered
R4529 T5415 T5414 advcl using,recovered
R4530 T5416 T5420 det the,system
R4531 T5417 T5420 compound Wizard,system
R4532 T5418 T5420 compound DNA,system
R4533 T5419 T5420 compound clean-up,system
R4534 T5420 T5415 dobj system,using
R4535 T5421 T5420 punct (,system
R4536 T5422 T5420 appos Promega,system
R4537 T5423 T5422 punct ",",Promega
R4538 T5424 T5422 conj Mannheim,Promega
R4539 T5425 T5424 punct ",",Mannheim
R4540 T5426 T5424 conj Germany,Mannheim
R4541 T5427 T5420 punct ),system
R4542 T5428 T5414 punct .,recovered
R4543 T5429 T5431 det The,DNA
R4544 T5430 T5431 amod purified,DNA
R4545 T5431 T5432 nsubj DNA,was
R4546 T5432 T5432 ROOT was,was
R4547 T5433 T5434 advmod subsequently,mixed
R4548 T5434 T5432 acomp mixed,was
R4549 T5435 T5434 prep with,mixed
R4550 T5436 T5438 nummod 1,NaOH
R4551 T5437 T5438 compound M,NaOH
R4552 T5438 T5435 pobj NaOH,with
R4553 T5439 T5434 prep to,mixed
R4554 T5440 T5442 det a,concentration
R4555 T5441 T5442 amod final,concentration
R4556 T5442 T5439 pobj concentration,to
R4557 T5443 T5442 prep of,concentration
R4558 T5444 T5445 nummod 0.3,M
R4559 T5445 T5443 pobj M,of
R4560 T5446 T5434 cc and,mixed
R4561 T5447 T5434 conj incubated,mixed
R4562 T5448 T5447 prep for,incubated
R4563 T5449 T5450 nummod 20,min
R4564 T5450 T5448 pobj min,for
R4565 T5451 T5447 prep at,incubated
R4566 T5452 T5453 nummod 37,°
R4567 T5453 T5454 nummod °,C
R4568 T5454 T5451 pobj C,at
R4569 T5455 T5456 aux to,ensure
R4570 T5456 T5447 advcl ensure,incubated
R4571 T5457 T5458 amod complete,desulfonisation
R4572 T5458 T5456 dobj desulfonisation,ensure
R4573 T5459 T5432 punct .,was
R4574 T5460 T5461 nsubj DNA,was
R4575 T5461 T5461 ROOT was,was
R4576 T5462 T5461 attr ethanol,was
R4577 T5463 T5462 acl precipitated,ethanol
R4578 T5464 T5463 prep in,precipitated
R4579 T5465 T5466 det the,presence
R4580 T5466 T5464 pobj presence,in
R4581 T5467 T5466 prep of,presence
R4582 T5468 T5469 compound 1/10,vol
R4583 T5469 T5467 pobj vol,of
R4584 T5470 T5469 prep of,vol
R4585 T5471 T5474 nummod 3,acetate
R4586 T5472 T5474 compound M,acetate
R4587 T5473 T5474 compound sodium,acetate
R4588 T5474 T5470 pobj acetate,of
R4589 T5475 T5466 punct ",",presence
R4590 T5476 T5461 conj washed,was
R4591 T5477 T5476 prep with,washed
R4592 T5478 T5479 nummod 70,%
R4593 T5479 T5480 compound %,ethanol
R4594 T5480 T5477 pobj ethanol,with
R4595 T5481 T5480 cc and,ethanol
R4596 T5482 T5476 conj resuspended,washed
R4597 T5483 T5482 prep in,resuspended
R4598 T5484 T5485 nummod 50,µl
R4599 T5485 T5483 pobj µl,in
R4600 T5486 T5485 appos H2O,µl
R4601 T5487 T5461 punct .,was
R4602 T5488 T5490 amod Subsequent,amplification
R4603 T5489 T5490 compound PCR,amplification
R4604 T5490 T5497 nsubjpass amplification,used
R4605 T5491 T5490 prep of,amplification
R4606 T5492 T5493 nummod 4,µl
R4607 T5493 T5495 nmod µl,DNA
R4608 T5494 T5495 amod bisulfite-treated,DNA
R4609 T5495 T5491 pobj DNA,of
R4610 T5496 T5497 auxpass was,used
R4611 T5497 T5497 ROOT used,used
R4612 T5498 T5497 prep for,used
R4613 T5499 T5498 pobj cloning,for
R4614 T5500 T5499 prep of,cloning
R4615 T5501 T5502 nummod two,fragments
R4616 T5502 T5500 pobj fragments,of
R4617 T5503 T5502 prep of,fragments
R4618 T5504 T5506 det the,promoter
R4619 T5505 T5506 compound IRF-4,promoter
R4620 T5506 T5503 pobj promoter,of
R4621 T5507 T5506 punct (,promoter
R4622 T5508 T5506 appos BS-I,promoter
R4623 T5509 T5508 cc and,BS-I
R4624 T5510 T5508 conj BS-II,BS-I
R4625 T5511 T5506 punct ),promoter
R4626 T5512 T5497 prep into,used
R4627 T5513 T5515 amod pCR2,vector
R4628 T5514 T5515 nummod .1,vector
R4629 T5515 T5512 pobj vector,into
R4630 T5516 T5515 prep with,vector
R4631 T5517 T5521 det the,kit
R4632 T5518 T5519 compound TOPO,TA
R4633 T5519 T5520 nsubj TA,cloning
R4634 T5520 T5521 compound cloning,kit
R4635 T5521 T5516 pobj kit,with
R4636 T5522 T5521 punct (,kit
R4637 T5523 T5521 appos Invitrogen,kit
R4638 T5524 T5521 punct ),kit
R4639 T5525 T5521 punct (,kit
R4640 T5526 T5497 xcomp see,used
R4641 T5527 T5528 compound Figure,3A
R4642 T5528 T5526 dobj 3A,see
R4643 T5529 T5526 punct ),see
R4644 T5530 T5497 punct .,used
R4645 T5531 T5532 det The,primers
R4646 T5532 T5543 nsubj primers,contain
R4647 T5533 T5532 acl used,primers
R4648 T5534 T5533 prep for,used
R4649 T5535 T5536 compound PCR,amplification
R4650 T5536 T5534 pobj amplification,for
R4651 T5537 T5536 prep of,amplification
R4652 T5538 T5539 det the,BS-I
R4653 T5539 T5537 pobj BS-I,of
R4654 T5540 T5539 cc and,BS-I
R4655 T5541 T5539 conj BS-II,BS-I
R4656 T5542 T5543 nsubj fragments,contain
R4657 T5543 T5543 ROOT contain,contain
R4658 T5544 T5547 det the,sequence
R4659 T5545 T5547 amod putative,sequence
R4660 T5546 T5547 amod altered,sequence
R4661 T5547 T5543 dobj sequence,contain
R4662 T5548 T5547 prep of,sequence
R4663 T5549 T5551 det the,strand
R4664 T5550 T5551 compound sense,strand
R4665 T5551 T5548 pobj strand,of
R4666 T5552 T5547 amod due,sequence
R4667 T5553 T5554 aux to,bisulfite
R4668 T5554 T5552 xcomp bisulfite,due
R4669 T5555 T5554 dobj treatment,bisulfite
R4670 T5556 T5561 punct (,written
R4671 T5557 T5559 amod converted,residues
R4672 T5558 T5559 compound cytosine,residues
R4673 T5559 T5561 nsubjpass residues,written
R4674 T5560 T5561 auxpass are,written
R4675 T5561 T5543 parataxis written,contain
R4676 T5562 T5561 prep in,written
R4677 T5563 T5564 amod bold,letters
R4678 T5564 T5562 pobj letters,in
R4679 T5565 T5561 punct ),written
R4680 T5566 T5561 punct :,written
R4681 T5567 T5572 nmod BS-I-forward,′
R4682 T5568 T5567 nummod 5,BS-I-forward
R4683 T5569 T5571 punct ′,TATTTGGATTTTTAGGGAGTTTTTTTT-3
R4684 T5570 T5571 punct -,TATTTGGATTTTTAGGGAGTTTTTTTT-3
R4685 T5571 T5572 compound TATTTGGATTTTTAGGGAGTTTTTTTT-3,′
R4686 T5572 T5561 dep ′,written
R4687 T5573 T5572 punct ",",′
R4688 T5574 T5578 dep BS-I-reverse,ACCCAACTCCCTTAAACTATTAAACT-3
R4689 T5575 T5574 nummod 5,BS-I-reverse
R4690 T5576 T5578 punct ′,ACCCAACTCCCTTAAACTATTAAACT-3
R4691 T5577 T5578 punct -,ACCCAACTCCCTTAAACTATTAAACT-3
R4692 T5578 T5579 compound ACCCAACTCCCTTAAACTATTAAACT-3,′
R4693 T5579 T5572 appos ′,′
R4694 T5580 T5579 punct (,′
R4695 T5581 T5582 nummod 187,bp
R4696 T5582 T5579 appos bp,′
R4697 T5583 T5579 punct ),′
R4698 T5584 T5572 punct ;,′
R4699 T5585 T5590 nmod BS-II-forward,′
R4700 T5586 T5585 nummod 5,BS-II-forward
R4701 T5587 T5589 punct ′,AGTTTAATAGTTTAAGGGAGTTGGGT-3
R4702 T5588 T5589 punct -,AGTTTAATAGTTTAAGGGAGTTGGGT-3
R4703 T5589 T5590 compound AGTTTAATAGTTTAAGGGAGTTGGGT-3,′
R4704 T5590 T5572 appos ′,′
R4705 T5591 T5590 punct ",",′
R4706 T5592 T5596 dep BS-II-reverse,CTCACCCTAAACTCAAAACTAAAAAC-3
R4707 T5593 T5592 nummod 5,BS-II-reverse
R4708 T5594 T5596 punct ′,CTCACCCTAAACTCAAAACTAAAAAC-3
R4709 T5595 T5596 punct -,CTCACCCTAAACTCAAAACTAAAAAC-3
R4710 T5596 T5597 compound CTCACCCTAAACTCAAAACTAAAAAC-3,′
R4711 T5597 T5590 appos ′,′
R4712 T5598 T5597 punct (,′
R4713 T5599 T5600 nummod 674,bp
R4714 T5600 T5597 appos bp,′
R4715 T5601 T5597 punct ),′
R4716 T5602 T5543 punct .,contain
R4717 T5603 T5621 prep After,sequenced
R4718 T5604 T5605 amod bacterial,amplification
R4719 T5605 T5603 pobj amplification,After
R4720 T5606 T5605 prep of,amplification
R4721 T5607 T5610 det the,fragments
R4722 T5608 T5610 amod cloned,fragments
R4723 T5609 T5610 compound PCR,fragments
R4724 T5610 T5606 pobj fragments,of
R4725 T5611 T5605 prep by,amplification
R4726 T5612 T5613 amod standard,procedures
R4727 T5613 T5611 pobj procedures,by
R4728 T5614 T5621 punct ",",sequenced
R4729 T5615 T5616 nummod eight,clones
R4730 T5616 T5621 nsubjpass clones,sequenced
R4731 T5617 T5616 prep from,clones
R4732 T5618 T5619 det each,sample
R4733 T5619 T5617 pobj sample,from
R4734 T5620 T5621 auxpass were,sequenced
R4735 T5621 T5621 ROOT sequenced,sequenced
R4736 T5622 T5621 prep with,sequenced
R4737 T5623 T5625 det an,sequencer
R4738 T5624 T5625 amod automated,sequencer
R4739 T5625 T5622 pobj sequencer,with
R4740 T5626 T5625 punct (,sequencer
R4741 T5627 T5628 compound ABI,Prism
R4742 T5628 T5625 appos Prism,sequencer
R4743 T5629 T5628 nummod 377,Prism
R4744 T5630 T5628 punct ",",Prism
R4745 T5631 T5632 compound Applied,Biosystems
R4746 T5632 T5628 appos Biosystems,Prism
R4747 T5633 T5625 punct ),sequencer
R4748 T5634 T5621 punct .,sequenced
R4926 T5873 T5887 prep In,provided
R4927 T5874 T5875 amod vitro,methylation
R4928 T5875 T5873 pobj methylation,In
R4929 T5876 T5875 cc and,methylation
R4930 T5877 T5878 compound reporter,gene
R4931 T5878 T5879 compound gene,assays
R4932 T5879 T5884 nsubj assays,construct
R4933 T5880 T5883 det The,gene
R4934 T5881 T5883 amod IRF-4,gene
R4935 T5882 T5883 compound promoter-reporter,gene
R4936 T5883 T5884 compound gene,construct
R4937 T5884 T5887 csubjpass construct,provided
R4938 T5885 T5887 auxpass was,provided
R4939 T5886 T5887 advmod generously,provided
R4940 T5887 T5887 ROOT provided,provided
R4941 T5888 T5887 agent by,provided
R4942 T5889 T5890 compound J.,Hiscott
R4943 T5890 T5888 pobj Hiscott,by
R4944 T5891 T5890 punct (,Hiscott
R4945 T5892 T5890 appos 31,Hiscott
R4946 T5893 T5890 punct ),Hiscott
R4947 T5894 T5887 punct .,provided
R4948 T5895 T5897 nsubjpass Constructs,methylated
R4949 T5896 T5897 auxpass were,methylated
R4950 T5897 T5897 ROOT methylated,methylated
R4951 T5898 T5897 prep in,methylated
R4952 T5899 T5898 pobj vitro,in
R4953 T5900 T5897 prep with,methylated
R4954 T5901 T5902 compound CpG,Methylase
R4955 T5902 T5900 pobj Methylase,with
R4956 T5903 T5904 punct (,M.Sss
R4957 T5904 T5902 appos M.Sss,Methylase
R4958 T5905 T5904 appos I,M.Sss
R4959 T5906 T5904 punct ),M.Sss
R4960 T5907 T5908 mark as,recommended
R4961 T5908 T5897 advcl recommended,methylated
R4962 T5909 T5908 agent by,recommended
R4963 T5910 T5911 det the,manufacturer
R4964 T5911 T5909 pobj manufacturer,by
R4965 T5912 T5914 punct (,Biolabs
R4966 T5913 T5914 compound NE,Biolabs
R4967 T5914 T5911 appos Biolabs,manufacturer
R4968 T5915 T5914 punct ),Biolabs
R4969 T5916 T5908 cc and,recommended
R4970 T5917 T5918 amod complete,methylation
R4971 T5918 T5920 nsubjpass methylation,checked
R4972 T5919 T5920 auxpass was,checked
R4973 T5920 T5897 conj checked,methylated
R4974 T5921 T5920 prep via,checked
R4975 T5922 T5923 compound restriction,analysis
R4976 T5923 T5921 pobj analysis,via
R4977 T5924 T5926 punct (,5A
R4978 T5925 T5926 nmod Figure,5A
R4979 T5926 T5923 appos 5A,analysis
R4980 T5927 T5926 punct ),5A
R4981 T5928 T5920 punct .,checked
R4982 T5929 T5931 compound Reporter,assays
R4983 T5930 T5931 compound gene,assays
R4984 T5931 T5941 nsubjpass assays,performed
R4985 T5932 T5931 acl using,assays
R4986 T5933 T5936 det the,assay
R4987 T5934 T5935 amod dual,luciferase
R4988 T5935 T5936 compound luciferase,assay
R4989 T5936 T5932 dobj assay,using
R4990 T5937 T5936 punct (,assay
R4991 T5938 T5936 appos Promega,assay
R4992 T5939 T5936 punct ),assay
R4993 T5940 T5941 auxpass were,performed
R4994 T5941 T5941 ROOT performed,performed
R4995 T5942 T5941 oprd similar,performed
R4996 T5943 T5942 prep to,similar
R4997 T5944 T5945 amod previous,reports
R4998 T5945 T5943 pobj reports,to
R4999 T5946 T5947 punct (,29
R5000 T5947 T5945 appos 29,reports
R5001 T5948 T5941 punct ),performed
R5002 T5949 T5941 punct .,performed
R5003 T5950 T5957 advmod Briefly,construct
R5004 T5951 T5957 punct ",",construct
R5005 T5952 T5953 nummod 5,nM
R5006 T5953 T5957 nsubj nM,construct
R5007 T5954 T5953 prep of,nM
R5008 T5955 T5956 det the,reporter
R5009 T5956 T5954 pobj reporter,of
R5010 T5957 T5957 ROOT construct,construct
R5011 T5958 T5957 cc and,construct
R5012 T5959 T5961 det the,control
R5013 T5960 T5961 compound transfection,control
R5014 T5961 T5969 nsubjpass control,transientlyco-expressed
R5015 T5962 T5969 csubjpass construct,transientlyco-expressed
R5016 T5963 T5962 xcomp expressing,construct
R5017 T5964 T5967 det the,gene
R5018 T5965 T5967 nmod renilla,gene
R5019 T5966 T5967 compound luciferase,gene
R5020 T5967 T5963 dobj gene,expressing
R5021 T5968 T5969 auxpass were,transientlyco-expressed
R5022 T5969 T5957 conj transientlyco-expressed,construct
R5023 T5970 T5969 prep via,transientlyco-expressed
R5024 T5971 T5970 pobj electroporation,via
R5025 T5972 T5957 punct .,construct
R5026 T5973 T5974 det The,control
R5027 T5974 T5976 nsubj control,served
R5028 T5975 T5976 nsubj construct,served
R5029 T5976 T5976 ROOT served,served
R5030 T5977 T5976 prep as,served
R5031 T5978 T5980 det an,reference
R5032 T5979 T5980 amod internal,reference
R5033 T5980 T5977 pobj reference,as
R5034 T5981 T5980 prep for,reference
R5035 T5982 T5983 compound transfection,efficiency
R5036 T5983 T5981 pobj efficiency,for
R5037 T5984 T5976 punct .,served
R5038 T5985 T5986 amod Forty-eight,hours
R5039 T5986 T5987 npadvmod hours,after
R5040 T5987 T5993 prep after,measured
R5041 T5988 T5987 pobj transfection,after
R5042 T5989 T5993 punct ",",measured
R5043 T5990 T5991 compound luciferase,activity
R5044 T5991 T5993 nsubjpass activity,measured
R5045 T5992 T5993 auxpass was,measured
R5046 T5993 T5993 ROOT measured,measured
R5047 T5994 T5993 prep with,measured
R5048 T5995 T5999 det a,microlumat
R5049 T5996 T5999 nmod LB,microlumat
R5050 T5997 T5999 nummod 96,microlumat
R5051 T5998 T5999 compound P,microlumat
R5052 T5999 T5994 pobj microlumat,with
R5053 T6000 T5999 punct (,microlumat
R5054 T6001 T6002 compound EG&G,Berthold
R5055 T6002 T5999 appos Berthold,microlumat
R5056 T6003 T6002 punct ",",Berthold
R5057 T6004 T6005 compound Bad,Wildbad
R5058 T6005 T6002 appos Wildbad,Berthold
R5059 T6006 T6005 punct ",",Wildbad
R5060 T6007 T6005 appos Germany,Wildbad
R5061 T6008 T6005 punct ),Wildbad
R5062 T6009 T5993 punct .,measured
R5063 T6010 T6012 nummod IRF-4,activation
R5064 T6011 T6012 compound promoter,activation
R5065 T6012 T6014 nsubjpass activation,quantified
R5066 T6013 T6014 auxpass was,quantified
R5067 T6014 T6014 ROOT quantified,quantified
R5068 T6015 T6014 prep as,quantified
R5069 T6016 T6017 det a,ratio
R5070 T6017 T6015 pobj ratio,as
R5071 T6018 T6017 prep of,ratio
R5072 T6019 T6022 amod measured,units
R5073 T6020 T6021 advmod firefly,light
R5074 T6021 T6022 amod light,units
R5075 T6022 T6018 pobj units,of
R5076 T6023 T6022 punct (,units
R5077 T6024 T6022 appos flu,units
R5078 T6025 T6022 punct ),units
R5079 T6026 T6017 amod relative,ratio
R5080 T6027 T6026 prep to,relative
R5081 T6028 T6027 pobj renilla,to
R5082 T6029 T6030 punct (,rlu
R5083 T6030 T6028 appos rlu,renilla
R5084 T6031 T6030 punct ),rlu
R5085 T6032 T6014 punct .,quantified
R5086 T6033 T6034 det Each,experiment
R5087 T6034 T6036 nsubjpass experiment,carried
R5088 T6035 T6036 auxpass was,carried
R5089 T6036 T6036 ROOT carried,carried
R5090 T6037 T6036 prt out,carried
R5091 T6038 T6039 advmod at,least
R5092 T6039 T6040 advmod least,three
R5093 T6040 T6041 nummod three,times
R5094 T6041 T6036 npadvmod times,carried
R5095 T6042 T6036 punct .,carried
R5410 T6468 T6475 nsubj Absence,is
R5411 T6469 T6468 prep of,Absence
R5412 T6470 T6471 compound IRF-4,expression
R5413 T6471 T6469 pobj expression,of
R5414 T6472 T6468 prep in,Absence
R5415 T6473 T6474 compound leukemia,cells
R5416 T6474 T6472 pobj cells,in
R5417 T6475 T6475 ROOT is,is
R5418 T6476 T6475 neg not,is
R5419 T6477 T6475 acomp due,is
R5420 T6478 T6479 aux to,promoter
R5421 T6479 T6477 xcomp promoter,due
R5422 T6480 T6475 conj alterations,is
R5423 T6481 T6484 nsubj We,demonstrated
R5424 T6482 T6484 aux have,demonstrated
R5425 T6483 T6484 advmod previously,demonstrated
R5426 T6484 T6480 relcl demonstrated,alterations
R5427 T6485 T6486 det a,lack
R5428 T6486 T6484 dobj lack,demonstrated
R5429 T6487 T6486 prep of,lack
R5430 T6488 T6489 compound IRF-4,expression
R5431 T6489 T6487 pobj expression,of
R5432 T6490 T6484 prep in,demonstrated
R5433 T6491 T6492 compound leukemia,patients
R5434 T6492 T6490 pobj patients,in
R5435 T6493 T6484 cc and,demonstrated
R5436 T6494 T6495 advmod specifically,in
R5437 T6495 T6484 conj in,demonstrated
R5438 T6496 T6497 compound CML,T-cells
R5439 T6497 T6495 pobj T-cells,in
R5440 T6498 T6497 punct (,T-cells
R5441 T6499 T6497 appos 3,T-cells
R5442 T6500 T6497 punct ),T-cells
R5443 T6501 T6475 punct .,is
R5444 T6502 T6505 advmod Here,demonstrate
R5445 T6503 T6505 punct ",",demonstrate
R5446 T6504 T6505 nsubj we,demonstrate
R5447 T6505 T6505 ROOT demonstrate,demonstrate
R5448 T6506 T6507 det the,absence
R5449 T6507 T6505 dobj absence,demonstrate
R5450 T6508 T6507 prep of,absence
R5451 T6509 T6510 compound IRF-4,expression
R5452 T6510 T6508 pobj expression,of
R5453 T6511 T6507 prep in,absence
R5454 T6512 T6515 amod various,lines
R5455 T6513 T6515 amod hematopoietic,lines
R5456 T6514 T6515 compound cell,lines
R5457 T6515 T6511 pobj lines,in
R5458 T6516 T6515 punct ",",lines
R5459 T6517 T6518 amod such,as
R5460 T6518 T6515 prep as,lines
R5461 T6519 T6518 pobj Jurkat,as
R5462 T6520 T6519 punct ",",Jurkat
R5463 T6521 T6523 det a,leukemia
R5464 T6522 T6523 compound T-cell,leukemia
R5465 T6523 T6519 conj leukemia,Jurkat
R5466 T6524 T6523 punct ",",leukemia
R5467 T6525 T6561 nmod CML-T1,leukemia
R5468 T6526 T6525 punct ",",CML-T1
R5469 T6527 T6530 det a,line
R5470 T6528 T6530 amod bcr-abl-positive,line
R5471 T6529 T6530 compound T-cell,line
R5472 T6530 T6525 appos line,CML-T1
R5473 T6531 T6532 punct ",",K-562
R5474 T6532 T6525 conj K-562,CML-T1
R5475 T6533 T6532 punct ",",K-562
R5476 T6534 T6536 det a,erythroleukemia
R5477 T6535 T6536 amod bcr-abl-positve,erythroleukemia
R5478 T6536 T6532 appos erythroleukemia,K-562
R5479 T6537 T6536 punct ",",erythroleukemia
R5480 T6538 T6536 conj U-937,erythroleukemia
R5481 T6539 T6538 punct ",",U-937
R5482 T6540 T6542 det a,leukemia
R5483 T6541 T6542 amod monocytic,leukemia
R5484 T6542 T6538 appos leukemia,U-937
R5485 T6543 T6542 punct ",",leukemia
R5486 T6544 T6542 conj EM-2,leukemia
R5487 T6545 T6544 cc and,EM-2
R5488 T6546 T6544 conj LAMA-84,EM-2
R5489 T6547 T6546 punct ",",LAMA-84
R5490 T6548 T6550 amod bcr-abl-positve,leukemia
R5491 T6549 T6550 amod myeloid,leukemia
R5492 T6550 T6546 conj leukemia,LAMA-84
R5493 T6551 T6550 punct ",",leukemia
R5494 T6552 T6550 cc but,leukemia
R5495 T6553 T6554 neg not,in
R5496 T6554 T6542 prep in,leukemia
R5497 T6555 T6554 pobj SD-1,in
R5498 T6556 T6554 punct ",",in
R5499 T6557 T6561 det a,leukemia
R5500 T6558 T6561 amod bcr-abl-positive,leukemia
R5501 T6559 T6561 amod acute,leukemia
R5502 T6560 T6561 amod lymphoblastic,leukemia
R5503 T6561 T6523 appos leukemia,leukemia
R5504 T6562 T6564 punct (,B-ALL
R5505 T6563 T6564 compound pre,B-ALL
R5506 T6564 T6561 appos B-ALL,leukemia
R5507 T6565 T6564 punct ),B-ALL
R5508 T6566 T6561 punct ",",leukemia
R5509 T6567 T6561 appos RPMI-8226,leukemia
R5510 T6568 T6567 punct ",",RPMI-8226
R5511 T6569 T6571 det a,myeloma
R5512 T6570 T6571 amod multiple,myeloma
R5513 T6571 T6567 appos myeloma,RPMI-8226
R5514 T6572 T6571 cc and,myeloma
R5515 T6573 T6571 conj BV-173,myeloma
R5516 T6574 T6573 punct ",",BV-173
R5517 T6575 T6578 det a,line
R5518 T6576 T6578 amod bcr-abl-positive,line
R5519 T6577 T6578 compound B-cell,line
R5520 T6578 T6573 appos line,BV-173
R5521 T6579 T6581 punct (,1A
R5522 T6580 T6581 compound Figures,1A
R5523 T6581 T6578 appos 1A,line
R5524 T6582 T6581 cc and,1A
R5525 T6583 T6581 conj 5D,1A
R5526 T6584 T6581 punct ),1A
R5527 T6585 T6505 punct .,demonstrate
R5528 T6586 T6596 prep After,excluded
R5529 T6587 T6586 pcomp sequencing,After
R5530 T6588 T6587 prep of,sequencing
R5531 T6589 T6591 det the,promoter
R5532 T6590 T6591 compound IRF-4,promoter
R5533 T6591 T6588 pobj promoter,of
R5534 T6592 T6596 punct ",",excluded
R5535 T6593 T6596 nsubjpass it,excluded
R5536 T6594 T6596 aux could,excluded
R5537 T6595 T6596 auxpass be,excluded
R5538 T6596 T6596 ROOT excluded,excluded
R5539 T6597 T6598 det that,absence
R5540 T6598 T6596 dobj absence,excluded
R5541 T6599 T6598 prep of,absence
R5542 T6600 T6601 compound IRF-4,expression
R5543 T6601 T6599 pobj expression,of
R5544 T6602 T6596 prep in,excluded
R5545 T6603 T6602 pobj any,in
R5546 T6604 T6603 prep of,any
R5547 T6605 T6608 det the,lines
R5548 T6606 T6608 amod above,lines
R5549 T6607 T6608 compound cell,lines
R5550 T6608 T6604 pobj lines,of
R5551 T6609 T6596 conj was,excluded
R5552 T6610 T6609 acomp due,was
R5553 T6611 T6610 xcomp to,due
R5554 T6612 T6613 amod genetic,aberrations
R5555 T6613 T6611 pobj aberrations,to
R5556 T6614 T6596 punct .,excluded
R5557 T6615 T6638 advmod However,detected
R5558 T6616 T6638 punct ",",detected
R5559 T6617 T6619 nummod 2,changes
R5560 T6618 T6619 compound bp,changes
R5561 T6619 T6638 nsubjpass changes,detected
R5562 T6620 T6619 punct (,changes
R5563 T6621 T6622 amod nucleotide,−
R5564 T6622 T6619 appos −,changes
R5565 T6623 T6622 appos 1081,−
R5566 T6624 T6638 punct ",",detected
R5567 T6625 T6638 nsubj T,detected
R5568 T6626 T6638 parataxis →,detected
R5569 T6627 T6626 dobj C,→
R5570 T6628 T6627 cc and,C
R5571 T6629 T6627 conj −,C
R5572 T6630 T6627 appos 1068,C
R5573 T6631 T6627 punct ",",C
R5574 T6632 T6634 det A,C
R5575 T6633 T6634 compound →,C
R5576 T6634 T6627 appos C,C
R5577 T6635 T6627 punct ),C
R5578 T6636 T6638 aux could,detected
R5579 T6637 T6638 auxpass be,detected
R5580 T6638 T6638 ROOT detected,detected
R5581 T6639 T6638 prep in,detected
R5582 T6640 T6643 preconj both,BV-173
R5583 T6641 T6643 det the,BV-173
R5584 T6642 T6643 compound IRF-4-positive,BV-173
R5585 T6643 T6639 pobj BV-173,in
R5586 T6644 T6643 cc and,BV-173
R5587 T6645 T6647 det the,LAMA-84
R5588 T6646 T6647 amod IRF-4-negative,LAMA-84
R5589 T6647 T6643 conj LAMA-84,BV-173
R5590 T6648 T6647 punct ",",LAMA-84
R5591 T6649 T6647 conj EM-2,LAMA-84
R5592 T6650 T6649 cc and,EM-2
R5593 T6651 T6649 conj K-562,EM-2
R5594 T6652 T6654 punct (,1B
R5595 T6653 T6654 compound Figure,1B
R5596 T6654 T6651 appos 1B,K-562
R5597 T6655 T6654 punct ),1B
R5598 T6656 T6638 punct .,detected
R5599 T6657 T6667 prep At,found
R5600 T6658 T6659 compound position,−
R5601 T6659 T6657 pobj −,At
R5602 T6660 T6659 nummod 116,−
R5603 T6661 T6665 det an,substitution
R5604 T6662 T6665 det A,substitution
R5605 T6663 T6665 amod →,substitution
R5606 T6664 T6665 compound C,substitution
R5607 T6665 T6667 nsubjpass substitution,found
R5608 T6666 T6667 auxpass was,found
R5609 T6667 T6667 ROOT found,found
R5610 T6668 T6667 prep in,found
R5611 T6669 T6668 pobj EM-2,in
R5612 T6670 T6669 punct ",",EM-2
R5613 T6671 T6669 conj K-562,EM-2
R5614 T6672 T6671 cc and,K-562
R5615 T6673 T6671 conj CML-T1,K-562
R5616 T6674 T6667 punct ",",found
R5617 T6675 T6681 mark whereas,exhibited
R5618 T6676 T6681 nsubj Jurkat,exhibited
R5619 T6677 T6676 punct ",",Jurkat
R5620 T6678 T6676 conj BV-173,Jurkat
R5621 T6679 T6678 cc and,BV-173
R5622 T6680 T6678 conj SD-1,BV-173
R5623 T6681 T6667 advcl exhibited,found
R5624 T6682 T6685 det a,sequence
R5625 T6683 T6685 amod mixed,sequence
R5626 T6684 T6685 compound A/C,sequence
R5627 T6685 T6681 dobj sequence,exhibited
R5628 T6686 T6685 cc and,sequence
R5629 T6687 T6685 conj U-937,sequence
R5630 T6688 T6687 punct ",",U-937
R5631 T6689 T6687 conj LAMA-84,U-937
R5632 T6690 T6689 cc and,LAMA-84
R5633 T6691 T6689 conj RPMI-8226,LAMA-84
R5634 T6692 T6693 det no,substitution
R5635 T6693 T6685 conj substitution,sequence
R5636 T6694 T6695 advmod at,all
R5637 T6695 T6693 advmod all,substitution
R5638 T6696 T6698 punct (,1B
R5639 T6697 T6698 compound Figure,1B
R5640 T6698 T6693 appos 1B,substitution
R5641 T6699 T6698 punct ),1B
R5642 T6700 T6667 punct .,found
R5643 T6701 T6705 advmod Consequently,are
R5644 T6702 T6705 punct ",",are
R5645 T6703 T6704 det these,alterations
R5646 T6704 T6705 nsubj alterations,are
R5647 T6705 T6705 ROOT are,are
R5648 T6706 T6705 acomp unlikely,are
R5649 T6707 T6708 aux to,affect
R5650 T6708 T6706 xcomp affect,unlikely
R5651 T6709 T6710 amod IRF-4,expression
R5652 T6710 T6708 dobj expression,affect
R5653 T6711 T6705 punct .,are
R6095 T7315 T7315 ROOT Increase,Increase
R6096 T7316 T7315 prep of,Increase
R6097 T7317 T7318 amod IRF-4,expression
R6098 T7318 T7316 pobj expression,of
R6099 T7319 T7318 prep in,expression
R6100 T7320 T7321 amod hematopoietic,cells
R6101 T7321 T7319 pobj cells,in
R6102 T7322 T7315 prep after,Increase
R6103 T7323 T7322 pcomp demethylating,after
R6104 T7324 T7323 dobj treatment,demethylating
R6105 T7325 T7327 nsubj We,analyzed
R6106 T7326 T7327 advmod next,analyzed
R6107 T7327 T7315 conj analyzed,Increase
R6108 T7328 T7332 mark whether,be
R6109 T7329 T7330 compound promoter,methylation
R6110 T7330 T7332 nsubj methylation,be
R6111 T7331 T7332 aux could,be
R6112 T7332 T7327 ccomp be,analyzed
R6113 T7333 T7332 acomp responsible,be
R6114 T7334 T7333 prep for,responsible
R6115 T7335 T7334 pobj down-regulation,for
R6116 T7336 T7335 prep of,down-regulation
R6117 T7337 T7338 compound IRF-4,expression
R6118 T7338 T7336 pobj expression,of
R6119 T7339 T7327 punct .,analyzed
R6120 T7340 T7341 det A,region
R6121 T7341 T7348 nsubj region,exhibited
R6122 T7342 T7341 prep including,region
R6123 T7343 T7342 pobj exon1,including
R6124 T7344 T7343 prep in,exon1
R6125 T7345 T7347 det the,promoter
R6126 T7346 T7347 compound IRF-4,promoter
R6127 T7347 T7344 pobj promoter,in
R6128 T7348 T7348 ROOT exhibited,exhibited
R6129 T7349 T7351 det a,number
R6130 T7350 T7351 amod large,number
R6131 T7351 T7348 dobj number,exhibited
R6132 T7352 T7351 prep of,number
R6133 T7353 T7354 compound CpG-rich,sequences
R6134 T7354 T7352 pobj sequences,of
R6135 T7355 T7357 punct (,3A
R6136 T7356 T7357 compound Figure,3A
R6137 T7357 T7351 appos 3A,number
R6138 T7358 T7351 punct ),number
R6139 T7359 T7348 punct .,exhibited
R6140 T7360 T7362 amod Several,substances
R6141 T7361 T7362 amod chemical,substances
R6142 T7362 T7374 nsubj substances,inhibit
R6143 T7363 T7364 amod such,as
R6144 T7364 T7362 prep as,substances
R6145 T7365 T7364 pobj 5-aza-2-deoxycytidine,as
R6146 T7366 T7365 punct (,5-aza-2-deoxycytidine
R6147 T7367 T7365 appos AzadC,5-aza-2-deoxycytidine
R6148 T7368 T7367 punct ),AzadC
R6149 T7369 T7365 cc or,5-aza-2-deoxycytidine
R6150 T7370 T7365 conj 5-azacytidine,5-aza-2-deoxycytidine
R6151 T7371 T7372 punct (,AzaC
R6152 T7372 T7370 appos AzaC,5-azacytidine
R6153 T7373 T7362 punct ),substances
R6154 T7374 T7374 ROOT inhibit,inhibit
R6155 T7375 T7376 compound de,novo
R6156 T7376 T7374 dobj novo,inhibit
R6157 T7377 T7376 cc and,novo
R6158 T7378 T7379 compound maintenance,methylation
R6159 T7379 T7376 conj methylation,novo
R6160 T7380 T7379 punct ",",methylation
R6161 T7381 T7374 cc and,inhibit
R6162 T7382 T7385 advmod thus,used
R6163 T7383 T7385 aux can,used
R6164 T7384 T7385 auxpass be,used
R6165 T7385 T7374 conj used,inhibit
R6166 T7386 T7387 aux to,discern
R6167 T7387 T7385 xcomp discern,used
R6168 T7388 T7389 compound promoter,methylation
R6169 T7389 T7387 dobj methylation,discern
R6170 T7390 T7389 punct (,methylation
R6171 T7391 T7389 appos "32,33",methylation
R6172 T7392 T7389 punct ),methylation
R6173 T7393 T7374 punct .,inhibit
R6174 T7394 T7395 nsubj We,used
R6175 T7395 T7395 ROOT used,used
R6176 T7396 T7395 dobj AzadC,used
R6177 T7397 T7398 aux to,generate
R6178 T7398 T7395 xcomp generate,used
R6179 T7399 T7400 amod unmethylated,DNA
R6180 T7400 T7398 dobj DNA,generate
R6181 T7401 T7395 punct .,used
R6182 T7402 T7405 det A,AzadC-treatment
R6183 T7403 T7404 nummod 72,h
R6184 T7404 T7405 compound h,AzadC-treatment
R6185 T7405 T7406 nsubj AzadC-treatment,resulted
R6186 T7406 T7406 ROOT resulted,resulted
R6187 T7407 T7406 prep in,resulted
R6188 T7408 T7410 det a,activation
R6189 T7409 T7410 amod concentration-dependent,activation
R6190 T7410 T7407 pobj activation,in
R6191 T7411 T7410 prep of,activation
R6192 T7412 T7413 compound IRF-4,transcription
R6193 T7413 T7411 pobj transcription,of
R6194 T7414 T7413 prep in,transcription
R6195 T7415 T7414 pobj Jurkat,in
R6196 T7416 T7415 cc and,Jurkat
R6197 T7417 T7415 conj CML-T1,Jurkat
R6198 T7418 T7414 pobj T-cells,in
R6199 T7419 T7421 advmod as,as
R6200 T7420 T7421 advmod well,as
R6201 T7421 T7414 cc as,in
R6202 T7422 T7414 conj in,in
R6203 T7423 T7429 nmod U-937,lines
R6204 T7424 T7423 punct ",",U-937
R6205 T7425 T7423 conj K-562,U-937
R6206 T7426 T7425 cc and,K-562
R6207 T7427 T7425 conj EM-2,K-562
R6208 T7428 T7429 compound cell,lines
R6209 T7429 T7422 pobj lines,in
R6210 T7430 T7432 punct (,2A
R6211 T7431 T7432 compound Figure,2A
R6212 T7432 T7429 appos 2A,lines
R6213 T7433 T7432 punct ),2A
R6214 T7434 T7406 punct .,resulted
R6215 T7435 T7436 nummod IRF-4,transcription
R6216 T7436 T7438 nsubjpass transcription,induced
R6217 T7437 T7438 auxpass was,induced
R6218 T7438 T7438 ROOT induced,induced
R6219 T7439 T7438 prep in,induced
R6220 T7440 T7442 det a,manner
R6221 T7441 T7442 amod time-dependent,manner
R6222 T7442 T7439 pobj manner,in
R6223 T7443 T7438 cc and,induced
R6224 T7444 T7445 auxpass was,observed
R6225 T7445 T7438 conj observed,induced
R6226 T7446 T7447 advmod as,early
R6227 T7447 T7445 advmod early,observed
R6228 T7448 T7456 mark as,increased
R6229 T7449 T7450 nummod 24,h
R6230 T7450 T7456 nsubj h,increased
R6231 T7451 T7450 prep after,h
R6232 T7452 T7451 pobj treatment,after
R6233 T7453 T7452 prep with,treatment
R6234 T7454 T7453 pobj AzadC,with
R6235 T7455 T7450 cc and,h
R6236 T7456 T7445 advcl increased,observed
R6237 T7457 T7456 prep over,increased
R6238 T7458 T7457 pobj time,over
R6239 T7459 T7456 prep until,increased
R6240 T7460 T7461 nummod 72,h
R6241 T7461 T7459 pobj h,until
R6242 T7462 T7463 punct (,Figure
R6243 T7463 T7464 compound Figure,2B
R6244 T7464 T7461 appos 2B,h
R6245 T7465 T7461 punct ),h
R6246 T7466 T7438 punct .,induced
R6247 T7467 T7476 nsubj Time,varied
R6248 T7468 T7467 cc and,Time
R6249 T7469 T7467 conj strength,Time
R6250 T7470 T7469 prep of,strength
R6251 T7471 T7472 det the,appearance
R6252 T7472 T7470 pobj appearance,of
R6253 T7473 T7472 prep of,appearance
R6254 T7474 T7475 compound IRF-4,transcripts
R6255 T7475 T7473 pobj transcripts,of
R6256 T7476 T7476 ROOT varied,varied
R6257 T7477 T7476 prep among,varied
R6258 T7478 T7479 compound cell,lines
R6259 T7479 T7477 pobj lines,among
R6260 T7480 T7483 punct ",",responded
R6261 T7481 T7482 advmod i.e.,CML-T1
R6262 T7482 T7483 nsubj CML-T1,responded
R6263 T7483 T7476 conj responded,varied
R6264 T7484 T7483 advmod strongest,responded
R6265 T7485 T7483 prep to,responded
R6266 T7486 T7485 pobj AzadC-treatment,to
R6267 T7487 T7490 punct (,shown
R6268 T7488 T7490 nsubjpass data,shown
R6269 T7489 T7490 neg not,shown
R6270 T7490 T7483 parataxis shown,responded
R6271 T7491 T7490 punct ),shown
R6272 T7492 T7483 punct .,responded
R6273 T7493 T7505 prep In,translated
R6274 T7494 T7493 pobj line,In
R6275 T7495 T7494 prep with,line
R6276 T7496 T7495 pobj this,with
R6277 T7497 T7505 punct ",",translated
R6278 T7498 T7503 nmod AzadC-treatment,cells
R6279 T7499 T7498 prep of,AzadC-treatment
R6280 T7500 T7499 pobj CML-T1,of
R6281 T7501 T7500 cc and,CML-T1
R6282 T7502 T7500 conj LAMA-84,CML-T1
R6283 T7503 T7505 nsubj cells,translated
R6284 T7504 T7505 advmod also,translated
R6285 T7505 T7505 ROOT translated,translated
R6286 T7506 T7505 prep in,translated
R6287 T7507 T7508 det an,induction
R6288 T7508 T7506 pobj induction,in
R6289 T7509 T7508 prep of,induction
R6290 T7510 T7512 compound IRF-4,expression
R6291 T7511 T7512 compound protein,expression
R6292 T7512 T7509 pobj expression,of
R6293 T7513 T7514 punct (,Figure
R6294 T7514 T7512 appos Figure,expression
R6295 T7515 T7514 nummod 2C,Figure
R6296 T7516 T7514 punct ),Figure
R6297 T7517 T7505 punct .,translated
R6298 T7518 T7533 advmod Accordingly,had
R6299 T7519 T7533 punct ",",had
R6300 T7520 T7533 nsubj treatment,had
R6301 T7521 T7520 prep of,treatment
R6302 T7522 T7526 det the,BV-173
R6303 T7523 T7526 amod IRF-4-positive,BV-173
R6304 T7524 T7525 compound cell,line
R6305 T7525 T7526 compound line,BV-173
R6306 T7526 T7521 pobj BV-173,of
R6307 T7527 T7526 punct ",",BV-173
R6308 T7528 T7526 conj SD-1,BV-173
R6309 T7529 T7528 cc and,SD-1
R6310 T7530 T7528 conj RPMI-8226,SD-1
R6311 T7531 T7526 prep with,BV-173
R6312 T7532 T7531 pobj AzadC,with
R6313 T7533 T7533 ROOT had,had
R6314 T7534 T7535 det no,effect
R6315 T7535 T7533 dobj effect,had
R6316 T7536 T7535 prep on,effect
R6317 T7537 T7538 amod IRF-4,expression
R6318 T7538 T7536 pobj expression,on
R6319 T7539 T7540 punct (,Figure
R6320 T7540 T7538 appos Figure,expression
R6321 T7541 T7540 nummod 2D,Figure
R6322 T7542 T7540 punct ),Figure
R6323 T7543 T7533 punct .,had
R6324 T7544 T7545 expl There,was
R6325 T7545 T7545 ROOT was,was
R6326 T7546 T7547 det no,difference
R6327 T7547 T7545 attr difference,was
R6328 T7548 T7547 prep in,difference
R6329 T7549 T7550 det the,effects
R6330 T7550 T7548 pobj effects,in
R6331 T7551 T7550 prep of,effects
R6332 T7552 T7551 pobj AzaC,of
R6333 T7553 T7552 cc versus,AzaC
R6334 T7554 T7552 conj AzadC,AzaC
R6335 T7555 T7545 punct ",",was
R6336 T7556 T7558 mark as,increased
R6337 T7557 T7558 nsubj both,increased
R6338 T7558 T7545 advcl increased,was
R6339 T7559 T7562 det the,level
R6340 T7560 T7561 compound IRF-4,mRNA
R6341 T7561 T7562 compound mRNA,level
R6342 T7562 T7558 dobj level,increased
R6343 T7563 T7558 prep in,increased
R6344 T7564 T7565 compound CML-T1,cells
R6345 T7565 T7563 pobj cells,in
R6346 T7566 T7567 advmod as,well
R6347 T7567 T7558 advmod well,increased
R6348 T7568 T7569 punct (,data
R6349 T7569 T7558 parataxis data,increased
R6350 T7570 T7571 neg not,shown
R6351 T7571 T7569 acl shown,data
R6352 T7572 T7569 punct ),data
R6353 T7573 T7545 punct .,was
R6354 T7574 T7575 nsubj This,implied
R6355 T7575 T7575 ROOT implied,implied
R6356 T7576 T7580 mark that,control
R6357 T7577 T7578 compound promoter,methylation
R6358 T7578 T7580 nsubj methylation,control
R6359 T7579 T7580 aux may,control
R6360 T7580 T7575 ccomp control,implied
R6361 T7581 T7582 amod IRF-4,expression
R6362 T7582 T7580 dobj expression,control
R6363 T7583 T7580 punct ",",control
R6364 T7584 T7575 cc but,implied
R6365 T7585 T7587 det an,explanation
R6366 T7586 T7587 amod alternative,explanation
R6367 T7587 T7589 nsubj explanation,be
R6368 T7588 T7589 aux may,be
R6369 T7589 T7575 conj be,implied
R6370 T7590 T7589 attr activation,be
R6371 T7591 T7590 prep of,activation
R6372 T7592 T7594 amod positive,regulators
R6373 T7593 T7594 amod transcriptional,regulators
R6374 T7594 T7591 pobj regulators,of
R6375 T7595 T7594 prep of,regulators
R6376 T7596 T7595 pobj IRF-4,of
R6377 T7597 T7589 prep by,be
R6378 T7598 T7597 pobj AzadC,by
R6379 T7599 T7598 punct (,AzadC
R6380 T7600 T7598 cc or,AzadC
R6381 T7601 T7598 conj AzaC,AzadC
R6382 T7602 T7589 punct ),be
R6383 T7603 T7589 punct .,be
R6753 T8113 T8114 amod Methylation-sensitive,enzymes
R6754 T8114 T8117 nsubj enzymes,cut
R6755 T8115 T8117 aux do,cut
R6756 T8116 T8117 neg not,cut
R6757 T8117 T8117 ROOT cut,cut
R6758 T8118 T8119 amod specific,sites
R6759 T8119 T8117 dobj sites,cut
R6760 T8120 T8119 prep in,sites
R6761 T8121 T8123 det the,promoter
R6762 T8122 T8123 compound IRF-4,promoter
R6763 T8123 T8120 pobj promoter,in
R6764 T8124 T8123 prep in,promoter
R6765 T8125 T8126 amod hematopoietic,cells
R6766 T8126 T8124 pobj cells,in
R6767 T8127 T8129 aux To,investigate
R6768 T8128 T8129 advmod further,investigate
R6769 T8129 T8117 conj investigate,cut
R6770 T8130 T8131 compound promoter,methylation
R6771 T8131 T8129 dobj methylation,investigate
R6772 T8132 T8129 prep as,investigate
R6773 T8133 T8135 det a,mechanism
R6774 T8134 T8135 amod regulatory,mechanism
R6775 T8135 T8132 pobj mechanism,as
R6776 T8136 T8135 prep of,mechanism
R6777 T8137 T8139 compound IRF-4,expression
R6778 T8138 T8139 compound gene,expression
R6779 T8139 T8136 pobj expression,of
R6780 T8140 T8143 punct ",",performed
R6781 T8141 T8143 nsubjpass restriction-PCR-assays,performed
R6782 T8142 T8143 auxpass were,performed
R6783 T8143 T8117 conj performed,cut
R6784 T8144 T8143 punct (,performed
R6785 T8145 T8143 npadvmod "20,24",performed
R6786 T8146 T8143 punct ),performed
R6787 T8147 T8143 punct ",",performed
R6788 T8148 T8155 advmod where,cut
R6789 T8149 T8151 amod only,DNA
R6790 T8150 T8151 amod methylated,DNA
R6791 T8151 T8155 nsubjpass DNA,cut
R6792 T8152 T8155 aux would,cut
R6793 T8153 T8155 neg not,cut
R6794 T8154 T8155 auxpass be,cut
R6795 T8155 T8143 advcl cut,performed
R6796 T8156 T8155 xcomp enabling,cut
R6797 T8157 T8159 amod subsequent,amplification
R6798 T8158 T8159 compound PCR,amplification
R6799 T8159 T8156 dobj amplification,enabling
R6800 T8160 T8159 cc and,amplification
R6801 T8161 T8162 compound vice,versa
R6802 T8162 T8159 conj versa,amplification
R6803 T8163 T8143 punct .,performed
R6804 T8164 T8165 compound Genomic,DNA
R6805 T8165 T8181 nsubjpass DNA,digested
R6806 T8166 T8165 prep from,DNA
R6807 T8167 T8168 amod leukemic,cells
R6808 T8168 T8166 pobj cells,from
R6809 T8169 T8165 conj Jurkat,DNA
R6810 T8170 T8169 punct ",",Jurkat
R6811 T8171 T8169 conj CML-T1,Jurkat
R6812 T8172 T8171 punct ",",CML-T1
R6813 T8173 T8171 conj U-937,CML-T1
R6814 T8174 T8173 punct ",",U-937
R6815 T8175 T8173 conj K-562,U-937
R6816 T8176 T8175 punct ",",K-562
R6817 T8177 T8175 conj EM-2,K-562
R6818 T8178 T8177 cc and,EM-2
R6819 T8179 T8177 conj BV-173,EM-2
R6820 T8180 T8181 auxpass was,digested
R6821 T8181 T8181 ROOT digested,digested
R6822 T8182 T8181 prep with,digested
R6823 T8183 T8185 det the,enzymes
R6824 T8184 T8185 amod methylation-sensitive,enzymes
R6825 T8185 T8182 pobj enzymes,with
R6826 T8186 T8185 appos HpaII,enzymes
R6827 T8187 T8186 punct ",",HpaII
R6828 T8188 T8186 conj Bsh1236I,HpaII
R6829 T8189 T8188 cc and,Bsh1236I
R6830 T8190 T8191 compound HaeII-isochizomer,Bsp143II
R6831 T8191 T8188 conj Bsp143II,Bsh1236I
R6832 T8192 T8181 punct .,digested
R6833 T8193 T8210 nsubj EcoRI,served
R6834 T8194 T8193 punct ",",EcoRI
R6835 T8195 T8196 nsubj which,has
R6836 T8196 T8193 relcl has,EcoRI
R6837 T8197 T8199 det no,site
R6838 T8198 T8199 compound recognition,site
R6839 T8199 T8196 dobj site,has
R6840 T8200 T8199 prep within,site
R6841 T8201 T8203 det the,promoter
R6842 T8202 T8203 compound IRF-4,promoter
R6843 T8203 T8200 pobj promoter,within
R6844 T8204 T8193 punct ",",EcoRI
R6845 T8205 T8193 cc and,EcoRI
R6846 T8206 T8208 det the,enzyme
R6847 T8207 T8208 amod methylation-resistant,enzyme
R6848 T8208 T8210 nsubj enzyme,served
R6849 T8209 T8208 appos MspI,enzyme
R6850 T8210 T8210 ROOT served,served
R6851 T8211 T8210 prep as,served
R6852 T8212 T8211 pobj controls,as
R6853 T8213 T8210 punct .,served
R6854 T8214 T8217 nummod Two,reactions
R6855 T8215 T8217 amod separate,reactions
R6856 T8216 T8217 compound amplification,reactions
R6857 T8217 T8219 nsubjpass reactions,performed
R6858 T8218 T8219 auxpass were,performed
R6859 T8219 T8219 ROOT performed,performed
R6860 T8220 T8219 punct ",",performed
R6861 T8221 T8219 advcl generating,performed
R6862 T8222 T8223 nummod two,fragments
R6863 T8223 T8221 dobj fragments,generating
R6864 T8224 T8223 punct ",",fragments
R6865 T8225 T8223 appos F1,fragments
R6866 T8226 T8225 cc and,F1
R6867 T8227 T8230 compound F2,3A
R6868 T8228 T8229 punct (,Figure
R6869 T8229 T8230 compound Figure,3A
R6870 T8230 T8225 conj 3A,F1
R6871 T8231 T8223 punct ),fragments
R6872 T8232 T8219 punct .,performed
R6873 T8233 T8248 prep After,detected
R6874 T8234 T8233 pobj digestion,After
R6875 T8235 T8234 prep with,digestion
R6876 T8236 T8235 pobj HpaII,with
R6877 T8237 T8236 cc and,HpaII
R6878 T8238 T8236 conj Bsp143II,HpaII
R6879 T8239 T8242 det a,amplification
R6880 T8240 T8242 amod sufficient,amplification
R6881 T8241 T8242 compound PCR,amplification
R6882 T8242 T8248 nsubjpass amplification,detected
R6883 T8243 T8242 prep of,amplification
R6884 T8244 T8243 pobj F1,of
R6885 T8245 T8244 cc and,F1
R6886 T8246 T8244 conj F2,F1
R6887 T8247 T8248 auxpass was,detected
R6888 T8248 T8248 ROOT detected,detected
R6889 T8249 T8248 prep in,detected
R6890 T8250 T8249 pobj DNA,in
R6891 T8251 T8248 prep from,detected
R6892 T8252 T8253 compound IRF-4-negative,Jurkat
R6893 T8253 T8251 pobj Jurkat,from
R6894 T8254 T8253 punct ",",Jurkat
R6895 T8255 T8253 conj CML-T1,Jurkat
R6896 T8256 T8255 punct ",",CML-T1
R6897 T8257 T8255 conj U-937,CML-T1
R6898 T8258 T8257 punct ",",U-937
R6899 T8259 T8257 conj K-562,U-937
R6900 T8260 T8259 cc and,K-562
R6901 T8261 T8259 conj EM-2,K-562
R6902 T8262 T8251 pobj cells,from
R6903 T8263 T8248 punct ",",detected
R6904 T8264 T8248 advcl suggesting,detected
R6905 T8265 T8267 det a,methylation
R6906 T8266 T8267 compound promoter,methylation
R6907 T8267 T8264 dobj methylation,suggesting
R6908 T8268 T8267 punct (,methylation
R6909 T8269 T8267 cc and,methylation
R6910 T8270 T8271 compound restriction,protection
R6911 T8271 T8267 conj protection,methylation
R6912 T8272 T8267 punct ),methylation
R6913 T8273 T8264 prep at,suggesting
R6914 T8274 T8277 det the,sites
R6915 T8275 T8277 amod respective,sites
R6916 T8276 T8277 compound recognition,sites
R6917 T8277 T8273 pobj sites,at
R6918 T8278 T8280 punct (,3B
R6919 T8279 T8280 amod Figure,3B
R6920 T8280 T8277 appos 3B,sites
R6921 T8281 T8280 cc and,3B
R6922 T8282 T8280 conj C,3B
R6923 T8283 T8282 punct ),C
R6924 T8284 T8248 punct .,detected
R6925 T8285 T8297 advmod Notably,inhibited
R6926 T8286 T8297 punct ",",inhibited
R6927 T8287 T8297 prep in,inhibited
R6928 T8288 T8290 amod IRF-4-positive,cells
R6929 T8289 T8290 amod SD-1,cells
R6930 T8290 T8291 compound cells,digestion
R6931 T8291 T8287 pobj digestion,in
R6932 T8292 T8291 prep with,digestion
R6933 T8293 T8295 det the,enzymes
R6934 T8294 T8295 amod methylation-sensitive,enzymes
R6935 T8295 T8292 pobj enzymes,with
R6936 T8296 T8297 advmod completely,inhibited
R6937 T8297 T8297 ROOT inhibited,inhibited
R6938 T8298 T8297 dobj amplification,inhibited
R6939 T8299 T8298 prep of,amplification
R6940 T8300 T8299 pobj F1,of
R6941 T8301 T8300 cc and,F1
R6942 T8302 T8300 conj F2,F1
R6943 T8303 T8297 punct .,inhibited
R6944 T8304 T8318 prep In,reduced
R6945 T8305 T8307 amod IRF-4-positive,cells
R6946 T8306 T8307 amod BV-173,cells
R6947 T8307 T8304 pobj cells,In
R6948 T8308 T8309 det a,HpaII
R6949 T8309 T8318 nsubj HpaII,reduced
R6950 T8310 T8309 punct ",",HpaII
R6951 T8311 T8315 cc but,digestion
R6952 T8312 T8315 neg not,digestion
R6953 T8313 T8315 det a,digestion
R6954 T8314 T8315 amod Bsh1236I,digestion
R6955 T8315 T8309 conj digestion,HpaII
R6956 T8316 T8318 punct ",",reduced
R6957 T8317 T8318 advmod significantly,reduced
R6958 T8318 T8318 ROOT reduced,reduced
R6959 T8319 T8322 det the,message
R6960 T8320 T8322 amod amplifiable,message
R6961 T8321 T8322 compound DNA,message
R6962 T8322 T8318 dobj message,reduced
R6963 T8323 T8322 prep of,message
R6964 T8324 T8323 pobj F2,of
R6965 T8325 T8327 punct (,3C
R6966 T8326 T8327 nmod Figure,3C
R6967 T8327 T8324 appos 3C,F2
R6968 T8328 T8327 punct ),3C
R6969 T8329 T8318 punct ",",reduced
R6970 T8330 T8336 mark whereas,affected
R6971 T8331 T8336 nsubjpass amplification,affected
R6972 T8332 T8331 prep of,amplification
R6973 T8333 T8332 pobj F1,of
R6974 T8334 T8336 auxpass was,affected
R6975 T8335 T8336 neg not,affected
R6976 T8336 T8318 advcl affected,reduced
R6977 T8337 T8339 punct (,3B
R6978 T8338 T8339 compound Figure,3B
R6979 T8339 T8336 npadvmod 3B,affected
R6980 T8340 T8336 punct ),affected
R6981 T8341 T8318 punct .,reduced
R6982 T8342 T8343 nsubj This,implied
R6983 T8343 T8343 ROOT implied,implied
R6984 T8344 T8353 mark that,associated
R6985 T8345 T8346 amod IRF-4,transcription
R6986 T8346 T8353 nsubjpass transcription,associated
R6987 T8347 T8346 prep in,transcription
R6988 T8348 T8347 pobj SD-1,in
R6989 T8349 T8348 cc and,SD-1
R7009 T8369 T8372 det the,cells
R7010 T8370 T8372 amod tested,cells
R7011 T8371 T8372 amod IRF-4-negative,cells
R7012 T8372 T8368 pobj cells,with
R7013 T8373 T8343 punct .,implied
R7513 T9022 T9024 amod Specific,sites
R7514 T9023 T9024 compound CpG,sites
R7515 T9024 T9030 nsubjpass sites,methylated
R7516 T9025 T9024 prep in,sites
R7517 T9026 T9028 det the,promoter
R7518 T9027 T9028 compound IRF-4,promoter
R7519 T9028 T9025 pobj promoter,in
R7520 T9029 T9030 auxpass are,methylated
R7521 T9030 T9030 ROOT methylated,methylated
R7522 T9031 T9030 prep in,methylated
R7523 T9032 T9033 amod hematopoietic,cells
R7524 T9033 T9031 pobj cells,in
R7525 T9034 T9048 prep In,treated
R7526 T9035 T9034 pobj order,In
R7527 T9036 T9038 aux to,map
R7528 T9037 T9038 advmod exactly,map
R7529 T9038 T9035 acl map,order
R7530 T9039 T9041 det the,sites
R7531 T9040 T9041 compound methylation,sites
R7532 T9041 T9038 dobj sites,map
R7533 T9042 T9041 prep within,sites
R7534 T9043 T9045 det the,promoter
R7535 T9044 T9045 compound IRF-4,promoter
R7536 T9045 T9042 pobj promoter,within
R7537 T9046 T9048 punct ",",treated
R7538 T9047 T9048 nsubj we,treated
R7539 T9048 T9048 ROOT treated,treated
R7540 T9049 T9060 nmod DNA,cells
R7541 T9050 T9049 prep of,DNA
R7542 T9051 T9050 pobj Jurkat,of
R7543 T9052 T9051 punct ",",Jurkat
R7544 T9053 T9051 conj CML-T1,Jurkat
R7545 T9054 T9053 punct ",",CML-T1
R7546 T9055 T9053 conj U-937,CML-T1
R7547 T9056 T9055 punct ",",U-937
R7548 T9057 T9055 conj K-562,U-937
R7549 T9058 T9057 cc and,K-562
R7550 T9059 T9057 conj EM-2,K-562
R7551 T9060 T9048 dobj cells,treated
R7552 T9061 T9063 advmod as,as
R7553 T9062 T9063 advmod well,as
R7554 T9063 T9048 prep as,treated
R7555 T9064 T9063 prep of,as
R7556 T9065 T9064 pobj SD-1,of
R7557 T9066 T9065 punct ",",SD-1
R7558 T9067 T9065 conj RPMI-8226,SD-1
R7559 T9068 T9067 cc and,RPMI-8226
R7560 T9069 T9067 conj BV-173,RPMI-8226
R7561 T9070 T9071 compound control,cells
R7562 T9071 T9048 advcl cells,treated
R7563 T9072 T9071 prep with,cells
R7564 T9073 T9072 pobj bisulfite,with
R7565 T9074 T9073 punct ",",bisulfite
R7566 T9075 T9077 nsubj which,converts
R7567 T9076 T9077 advmod chemically,converts
R7568 T9077 T9073 relcl converts,bisulfite
R7569 T9078 T9079 amod unmethylated,cytosine
R7570 T9079 T9077 dobj cytosine,converts
R7571 T9080 T9081 aux to,uracil
R7572 T9081 T9077 xcomp uracil,converts
R7573 T9082 T9048 punct ",",treated
R7574 T9083 T9085 mark whereas,has
R7575 T9084 T9085 nsubj it,has
R7576 T9085 T9048 advcl has,treated
R7577 T9086 T9087 det no,effect
R7578 T9087 T9085 dobj effect,has
R7579 T9088 T9087 prep on,effect
R7580 T9089 T9090 amod methylated,cytosine
R7581 T9090 T9088 pobj cytosine,on
R7582 T9091 T9085 punct ",",has
R7583 T9092 T9093 advmod i.e.,in
R7584 T9093 T9085 prep in,has
R7585 T9094 T9093 pobj CpG,in
R7586 T9095 T9094 punct (,CpG
R7587 T9096 T9094 appos 34,CpG
R7588 T9097 T9094 punct ),CpG
R7589 T9098 T9048 punct .,treated
R7590 T9099 T9100 det This,technique
R7591 T9100 T9101 nsubj technique,is
R7592 T9101 T9101 ROOT is,is
R7593 T9102 T9103 advmod especially,useful
R7594 T9103 T9101 acomp useful,is
R7595 T9104 T9103 prep for,useful
R7596 T9105 T9104 pobj detection,for
R7597 T9106 T9105 prep of,detection
R7598 T9107 T9109 amod unknown,patterns
R7599 T9108 T9109 compound methylation,patterns
R7600 T9109 T9106 pobj patterns,of
R7601 T9110 T9101 punct .,is
R7602 T9111 T9112 compound PCR,amplification
R7603 T9112 T9121 nsubj amplification,showed
R7604 T9113 T9112 punct ",",amplification
R7605 T9114 T9112 conj cloning,amplification
R7606 T9115 T9114 cc and,cloning
R7607 T9116 T9114 conj sequencing,cloning
R7608 T9117 T9116 prep of,sequencing
R7609 T9118 T9120 det the,DNA
R7610 T9119 T9120 amod bisulfite-treated,DNA
R7611 T9120 T9117 pobj DNA,of
R7612 T9121 T9121 ROOT showed,showed
R7613 T9122 T9125 det a,pattern
R7614 T9123 T9125 amod specific,pattern
R7615 T9124 T9125 compound methylation,pattern
R7616 T9125 T9121 dobj pattern,showed
R7617 T9126 T9125 prep of,pattern
R7618 T9127 T9131 det the,sites
R7619 T9128 T9131 amod analyzed,sites
R7620 T9129 T9131 nummod 62,sites
R7621 T9130 T9131 compound CpG,sites
R7622 T9131 T9126 pobj sites,of
R7623 T9132 T9131 prep in,sites
R7624 T9133 T9135 det all,lines
R7625 T9134 T9135 compound cell,lines
R7626 T9135 T9132 pobj lines,in
R7627 T9136 T9137 punct (,Figure
R7628 T9137 T9125 appos Figure,pattern
R7629 T9138 T9137 nummod 4,Figure
R7630 T9139 T9137 cc and,Figure
R7631 T9140 T9137 conj Table,Figure
R7632 T9141 T9140 nummod 1,Table
R7633 T9142 T9125 punct ),pattern
R7634 T9143 T9121 punct .,showed
R7635 T9144 T9150 prep In,ranged
R7636 T9145 T9144 amod general,In
R7637 T9146 T9150 punct ",",ranged
R7638 T9147 T9149 det the,status
R7639 T9148 T9149 amod methylational,status
R7640 T9149 T9150 nsubj status,ranged
R7641 T9150 T9150 ROOT ranged,ranged
R7642 T9151 T9150 prep from,ranged
R7643 T9152 T9154 nummod one,line
R7644 T9153 T9154 compound cell,line
R7645 T9154 T9151 pobj line,from
R7646 T9155 T9154 prep with,line
R7647 T9156 T9160 det a,promoter
R7648 T9157 T9158 advmod nearly,non-methylated
R7649 T9158 T9160 amod non-methylated,promoter
R7650 T9159 T9160 compound IRF-4,promoter
R7651 T9160 T9155 pobj promoter,with
R7652 T9161 T9160 punct (,promoter
R7653 T9162 T9160 appos SD-1,promoter
R7654 T9163 T9162 punct ",",SD-1
R7655 T9164 T9162 appos IRF-4-positive,SD-1
R7656 T9165 T9162 punct ),SD-1
R7657 T9166 T9160 prep to,promoter
R7658 T9167 T9171 det a,promoter
R7659 T9168 T9169 advmod completely,methylated
R7660 T9169 T9171 amod methylated,promoter
R7661 T9170 T9171 compound IRF-4,promoter
R7662 T9171 T9166 pobj promoter,to
R7663 T9172 T9171 prep in,promoter
R7664 T9173 T9172 pobj CML-T1,in
R7665 T9174 T9175 punct (,IRF-4-negative
R7666 T9175 T9173 appos IRF-4-negative,CML-T1
R7667 T9176 T9175 punct ),IRF-4-negative
R7668 T9177 T9150 punct .,ranged
R7669 T9178 T9192 advmod Interestingly,was
R7670 T9179 T9192 punct ",",was
R7671 T9180 T9181 det the,percentage
R7672 T9181 T9192 nsubj percentage,was
R7673 T9182 T9181 prep of,percentage
R7674 T9183 T9184 compound CpG,methylation
R7675 T9184 T9182 pobj methylation,of
R7676 T9185 T9181 prep in,percentage
R7677 T9186 T9188 det the,promoter
R7678 T9187 T9188 compound IRF-4,promoter
R7679 T9188 T9185 pobj promoter,in
R7680 T9189 T9188 prep from,promoter
R7681 T9190 T9191 amod IRF-4-positive,cells
R7682 T9191 T9189 pobj cells,from
R7683 T9192 T9192 ROOT was,was
R7684 T9193 T9194 advmod very,low
R7685 T9194 T9192 acomp low,was
R7686 T9195 T9206 punct (,mean
R7687 T9196 T9206 meta mean,mean
R7688 T9197 T9198 nummod 24,%
R7689 T9198 T9196 dobj %,mean
R7690 T9199 T9196 punct ),mean
R7691 T9200 T9206 prep as,mean
R7692 T9201 T9200 prep compared,as
R7693 T9202 T9201 prep with,compared
R7694 T9203 T9204 amod IRF-4-negative,cells
R7695 T9204 T9202 pobj cells,with
R7696 T9205 T9206 punct (,mean
R7697 T9206 T9192 parataxis mean,was
R7698 T9207 T9208 nummod 94,%
R7699 T9208 T9206 dobj %,mean
R7700 T9209 T9206 punct ),mean
R7701 T9210 T9212 punct (,4A
R7702 T9211 T9212 compound Figure,4A
R7703 T9212 T9192 attr 4A,was
R7704 T9213 T9212 cc and,4A
R7705 T9214 T9212 conj Table,4A
R7706 T9215 T9214 nummod 1,Table
R7707 T9216 T9214 punct ),Table
R7708 T9217 T9192 punct .,was
R7709 T9218 T9222 det A,region
R7710 T9219 T9222 nummod 5,region
R7711 T9220 T9222 punct ′,region
R7712 T9221 T9222 punct -,region
R7713 T9222 T9247 nsubjpass region,found
R7714 T9223 T9222 punct (,region
R7715 T9224 T9222 appos R1,region
R7716 T9225 T9222 punct ),region
R7717 T9226 T9222 prep with,region
R7718 T9227 T9230 nummod 13,sites
R7719 T9228 T9230 amod hypermethylated,sites
R7720 T9229 T9230 compound CpG,sites
R7721 T9230 T9226 pobj sites,with
R7722 T9231 T9230 punct (,sites
R7723 T9232 T9233 amod mean,number
R7724 T9233 T9230 appos number,sites
R7725 T9234 T9233 prep of,number
R7726 T9235 T9236 amod methylated,clones
R7727 T9236 T9234 pobj clones,of
R7728 T9237 T9233 appos 5.5,number
R7729 T9238 T9237 prep of,5.5
R7730 T9239 T9238 pobj 8,of
R7731 T9240 T9237 prep with,5.5
R7732 T9241 T9242 nummod 77,%
R7733 T9242 T9240 pobj %,with
R7734 T9243 T9244 amod methylated,CpGs
R7735 T9244 T9242 appos CpGs,%
R7736 T9245 T9233 punct ),number
R7737 T9246 T9247 auxpass was,found
R7738 T9247 T9247 ROOT found,found
R7739 T9248 T9247 prep in,found
R7740 T9249 T9250 amod most,cells
R7741 T9250 T9248 pobj cells,in
R7742 T9251 T9247 punct (,found
R7743 T9252 T9247 prep except,found
R7744 T9253 T9252 pobj SD-1,except
R7745 T9254 T9253 cc and,SD-1
R7746 T9255 T9253 conj RPMI-8226,SD-1
R7747 T9256 T9255 punct ),RPMI-8226
R7748 T9257 T9247 cc and,found
R7749 T9258 T9262 det a,region
R7750 T9259 T9262 nummod 3,region
R7751 T9260 T9262 punct ′,region
R7752 T9261 T9262 punct -,region
R7753 T9262 T9268 nsubj region,hypomethylated
R7754 T9263 T9262 punct (,region
R7755 T9264 T9262 appos R3,region
R7756 T9265 T9262 punct ),region
R7757 T9266 T9262 prep of,region
R7758 T9267 T9266 pobj 6,of
R7759 T9268 T9247 conj hypomethylated,found
R7760 T9269 T9270 compound CpG,sites
R7761 T9270 T9268 dobj sites,hypomethylated
R7762 T9271 T9270 punct (,sites
R7763 T9272 T9273 amod mean,number
R7764 T9273 T9287 nsubjpass number,found
R7765 T9274 T9273 prep of,number
R7766 T9275 T9276 amod methylated,clones
R7767 T9276 T9274 pobj clones,of
R7768 T9277 T9273 appos 1.7,number
R7769 T9278 T9277 prep of,1.7
R7770 T9279 T9278 pobj 8,of
R7771 T9280 T9277 prep with,1.7
R7772 T9281 T9282 nummod 33,%
R7773 T9282 T9284 compound %,CpGs
R7774 T9283 T9284 compound methylated,CpGs
R7775 T9284 T9280 pobj CpGs,with
R7776 T9285 T9273 punct ),number
R7777 T9286 T9287 auxpass was,found
R7778 T9287 T9268 conj found,hypomethylated
R7779 T9288 T9287 prep in,found
R7780 T9289 T9290 amod most,cells
R7781 T9290 T9288 pobj cells,in
R7782 T9291 T9287 punct (,found
R7783 T9292 T9287 prep except,found
R7784 T9293 T9292 pobj CML-T1,except
R7785 T9294 T9293 cc and,CML-T1
R7786 T9295 T9293 conj U-937,CML-T1
R7787 T9296 T9293 punct ),CML-T1
R7788 T9297 T9299 punct (,4A
R7789 T9298 T9299 compound Figure,4A
R7790 T9299 T9293 appos 4A,CML-T1
R7791 T9300 T9299 cc and,4A
R7792 T9301 T9299 conj Table,4A
R7793 T9302 T9301 nummod 1,Table
R7794 T9303 T9301 punct ),Table
R7795 T9304 T9287 punct .,found
R7796 T9305 T9321 advmod Intriguingly,detected
R7797 T9306 T9321 punct ",",detected
R7798 T9307 T9308 det a,stretch
R7799 T9308 T9321 nsubjpass stretch,detected
R7800 T9309 T9308 prep of,stretch
R7801 T9310 T9312 nummod 13,sites
R7802 T9311 T9312 compound CpG,sites
R7803 T9312 T9309 pobj sites,of
R7804 T9313 T9312 punct (,sites
R7805 T9314 T9315 nmod #,10
R7806 T9315 T9312 appos 10,sites
R7807 T9316 T9315 appos 22,10
R7808 T9317 T9315 punct ;,10
R7809 T9318 T9315 appos R2,10
R7810 T9319 T9312 punct ),sites
R7811 T9320 T9321 auxpass was,detected
R7812 T9321 T9321 ROOT detected,detected
R7813 T9322 T9321 prep in,detected
R7814 T9323 T9322 prep between,in
R7815 T9324 T9325 det these,regions
R7816 T9325 T9323 pobj regions,between
R7817 T9326 T9325 punct ",",regions
R7818 T9327 T9330 nsubjpass which,methylated
R7819 T9328 T9330 auxpass were,methylated
R7820 T9329 T9330 advmod highly,methylated
R7821 T9330 T9325 relcl methylated,regions
R7822 T9331 T9330 prep in,methylated
R7823 T9332 T9335 amod IRF-4-negative,number
R7824 T9333 T9335 punct (,number
R7825 T9334 T9335 amod mean,number
R7826 T9335 T9331 pobj number,in
R7827 T9336 T9335 prep of,number
R7828 T9337 T9338 amod methylated,clones
R7829 T9338 T9336 pobj clones,of
R7830 T9339 T9335 nummod 7.1,number
R7831 T9340 T9339 prep of,7.1
R7832 T9341 T9340 pobj 8,of
R7833 T9342 T9330 prep with,methylated
R7834 T9343 T9344 nummod 89,%
R7835 T9344 T9342 pobj %,with
R7836 T9345 T9346 amod methylated,CpGs
R7837 T9346 T9344 appos CpGs,%
R7838 T9347 T9330 punct ),methylated
R7839 T9348 T9330 cc but,methylated
R7840 T9349 T9350 advmod totally,non-methylated
R7841 T9350 T9321 conj non-methylated,detected
R7842 T9351 T9350 prep in,non-methylated
R7843 T9352 T9353 amod IRF-4-positive,cells
R7844 T9353 T9351 pobj cells,in
R7845 T9354 T9355 punct (,Figure
R7846 T9355 T9355 ROOT Figure,Figure
R7847 T9356 T9355 nummod 4A,Figure
R7848 T9357 T9355 cc and,Figure
R7849 T9358 T9355 conj B,Figure
R7850 T9359 T9355 punct ),Figure
R7851 T9360 T9321 punct .,detected
R7852 T9361 T9394 advmod Furthermore,showed
R7853 T9362 T9394 punct ",",showed
R7854 T9363 T9365 nummod three,sites
R7855 T9364 T9365 compound CpG,sites
R7856 T9365 T9394 nsubj sites,showed
R7857 T9366 T9365 prep at,sites
R7858 T9367 T9370 det the,end
R7859 T9368 T9369 nummod 5,′
R7860 T9369 T9370 compound ′,end
R7861 T9370 T9366 pobj end,at
R7862 T9371 T9370 punct (,end
R7863 T9372 T9377 punct #,58
R7864 T9373 T9372 nummod 54,#
R7865 T9374 T9375 punct ",",56
R7866 T9375 T9377 dep 56,58
R7867 T9376 T9377 punct ",",58
R7868 T9377 T9370 appos 58,end
R7869 T9378 T9370 punct ),end
R7870 T9379 T9365 cc and,sites
R7871 T9380 T9382 nummod two,motifs
R7872 T9381 T9382 compound CpG,motifs
R7873 T9382 T9365 conj motifs,sites
R7874 T9383 T9382 prep at,motifs
R7875 T9384 T9387 det the,end
R7876 T9385 T9386 nummod 3,′
R7877 T9386 T9387 compound ′,end
R7878 T9387 T9383 pobj end,at
R7879 T9388 T9394 punct (,showed
R7880 T9389 T9394 nsubj #,showed
R7881 T9390 T9389 nummod 1,#
R7882 T9391 T9389 punct ",",#
R7883 T9392 T9389 appos 2,#
R7884 T9393 T9394 punct ),showed
R7885 T9394 T9394 ROOT showed,showed
R7886 T9395 T9397 det this,correlation
R7887 T9396 T9397 amod direct,correlation
R7888 T9397 T9394 dobj correlation,showed
R7889 T9398 T9397 prep between,correlation
R7890 T9399 T9400 amod high,methylation
R7891 T9400 T9401 compound methylation,status
R7892 T9401 T9398 pobj status,between
R7893 T9402 T9401 cc and,status
R7894 T9403 T9401 conj absence,status
R7895 T9404 T9401 prep of,status
R7896 T9405 T9406 compound IRF-4,expression
R7897 T9406 T9404 pobj expression,of
R7898 T9407 T9394 punct .,showed
R7899 T9408 T9430 prep In,are
R7900 T9409 T9408 pobj addition,In
R7901 T9410 T9430 punct ",",are
R7902 T9411 T9413 nummod two,sites
R7903 T9412 T9413 compound CpG,sites
R7904 T9413 T9430 nsubj sites,are
R7905 T9414 T9413 acl located,sites
R7906 T9415 T9414 prep in,located
R7907 T9416 T9417 det a,NFκB
R7908 T9417 T9415 pobj NFκB,in
R7909 T9418 T9417 punct (,NFκB
R7910 T9419 T9420 nmod #,48
R7911 T9420 T9414 npadvmod 48,located
R7912 T9421 T9414 punct ),located
R7913 T9422 T9414 cc and,located
R7914 T9423 T9425 det a,element
R7915 T9424 T9425 compound SP1,element
R7916 T9425 T9413 conj element,sites
R7917 T9426 T9425 punct (,element
R7918 T9427 T9428 nmod #,45
R7919 T9428 T9425 appos 45,element
R7920 T9429 T9425 punct ),element
R7921 T9430 T9430 ROOT are,are
R7922 T9431 T9432 advmod less,methylated
R7923 T9432 T9430 attr methylated,are
R7924 T9433 T9432 prep in,methylated
R7925 T9434 T9433 pobj IRF-4-positive,in
R7926 T9435 T9432 prep than,methylated
R7927 T9436 T9435 prep in,than
R7928 T9437 T9438 amod IRF-4-negative,cells
R7929 T9438 T9436 pobj cells,in
R7930 T9439 T9432 punct (,methylated
R7931 T9440 T9441 amod mean,number
R7932 T9441 T9432 appos number,methylated
R7933 T9442 T9441 prep of,number
R7934 T9443 T9444 amod methylated,clones
R7935 T9444 T9442 pobj clones,of
R7936 T9445 T9441 punct :,number
R7937 T9446 T9441 appos 1/8,number
R7938 T9447 T9446 cc versus,1/8
R7939 T9448 T9446 conj 8/8,1/8
R7940 T9449 T9441 punct ),number
R7941 T9450 T9430 punct .,are
R7942 T9451 T9452 det These,results
R7943 T9452 T9453 nsubj results,indicate
R7944 T9453 T9453 ROOT indicate,indicate
R7945 T9454 T9455 det the,involvement
R7946 T9455 T9453 dobj involvement,indicate
R7947 T9456 T9455 prep of,involvement
R7948 T9457 T9458 compound CpG,methylation
R7949 T9458 T9456 pobj methylation,of
R7950 T9459 T9458 prep in,methylation
R7951 T9460 T9461 det the,regulation
R7952 T9461 T9459 pobj regulation,in
R7953 T9462 T9461 prep of,regulation
R7954 T9463 T9464 compound IRF-4,expression
R7955 T9464 T9462 pobj expression,of
R7956 T9465 T9461 prep in,regulation
R7957 T9466 T9467 amod leukemic,cells
R7958 T9467 T9465 pobj cells,in
R7959 T9468 T9453 punct .,indicate
R8203 T9878 T9886 prep In,decreases
R8204 T9879 T9880 amod vitro,methylation
R8205 T9880 T9878 pobj methylation,In
R8206 T9881 T9880 prep of,methylation
R8207 T9882 T9884 det an,promoter-reporter
R8208 T9883 T9884 amod IRF-4,promoter-reporter
R8209 T9884 T9881 pobj promoter-reporter,of
R8210 T9885 T9886 nsubj construct,decreases
R8211 T9886 T9886 ROOT decreases,decreases
R8212 T9887 T9888 poss its,activity
R8213 T9888 T9886 dobj activity,decreases
R8214 T9889 T9890 aux To,provide
R8215 T9890 T9886 advcl provide,decreases
R8216 T9891 T9890 dobj evidence,provide
R8217 T9892 T9891 prep for,evidence
R8218 T9893 T9895 det a,effect
R8219 T9894 T9895 amod direct,effect
R8220 T9895 T9892 pobj effect,for
R8221 T9896 T9895 prep of,effect
R8222 T9897 T9898 amod methylational,status
R8223 T9898 T9896 pobj status,of
R8224 T9899 T9898 prep on,status
R8225 T9900 T9902 compound IRF-4,activity
R8226 T9901 T9902 compound promoter,activity
R8227 T9902 T9899 pobj activity,on
R8228 T9903 T9904 nsubj we,performed
R8229 T9904 T9904 ROOT performed,performed
R8230 T9905 T9907 compound reporter,assays
R8231 T9906 T9907 compound gene,assays
R8232 T9907 T9904 dobj assays,performed
R8233 T9908 T9907 prep with,assays
R8234 T9909 T9911 amod IRF-4,constructs
R8235 T9910 T9911 compound promoter,constructs
R8236 T9911 T9908 pobj constructs,with
R8237 T9912 T9904 advmod before,performed
R8238 T9913 T9912 cc and,before
R8239 T9914 T9912 conj after,before
R8240 T9915 T9916 poss their,in
R8241 T9916 T9914 prep in,after
R8242 T9917 T9918 amod vitro,methylation
R8243 T9918 T9916 pobj methylation,in
R8244 T9919 T9904 punct .,performed
R8245 T9920 T9922 det A,methylation
R8246 T9921 T9922 amod complete,methylation
R8247 T9922 T9927 nsubjpass methylation,checked
R8248 T9923 T9922 prep of,methylation
R8249 T9924 T9925 det these,constructs
R8250 T9925 T9923 pobj constructs,of
R8251 T9926 T9927 auxpass was,checked
R8252 T9927 T9927 ROOT checked,checked
R8253 T9928 T9927 prep via,checked
R8254 T9929 T9930 compound restriction,assays
R8255 T9930 T9928 pobj assays,via
R8256 T9931 T9930 prep with,assays
R8257 T9932 T9933 amod methylation-sensitive,endonucleases
R8258 T9933 T9931 pobj endonucleases,with
R8259 T9934 T9936 punct (,5A
R8260 T9935 T9936 compound Figure,5A
R8261 T9936 T9933 appos 5A,endonucleases
R8262 T9937 T9936 punct ),5A
R8263 T9938 T9927 punct .,checked
R8264 T9939 T9947 advmod Intriguingly,decreased
R8265 T9940 T9947 punct ",",decreased
R8266 T9941 T9947 nsubj methylation,decreased
R8267 T9942 T9941 prep of,methylation
R8268 T9943 T9945 det the,promoter
R8269 T9944 T9945 compound IRF-4,promoter
R8270 T9945 T9942 pobj promoter,of
R8271 T9946 T9947 advmod significantly,decreased
R8272 T9947 T9947 ROOT decreased,decreased
R8273 T9948 T9949 compound promoter,activity
R8274 T9949 T9947 dobj activity,decreased
R8275 T9950 T9949 prep in,activity
R8276 T9951 T9953 amod IRF-4-positive,cells
R8277 T9952 T9953 compound SD-1,cells
R8278 T9953 T9950 pobj cells,in
R8279 T9954 T9947 prep by,decreased
R8280 T9955 T9956 nummod 85.0,%
R8281 T9956 T9954 pobj %,by
R8282 T9957 T9959 punct (,5B
R8283 T9958 T9959 compound Figure,5B
R8284 T9959 T9956 appos 5B,%
R8285 T9960 T9959 punct ),5B
R8286 T9961 T9947 punct .,decreased
R8287 T9962 T9964 det The,effect
R8288 T9963 T9964 amod silencing,effect
R8289 T9964 T9970 nsubjpass effect,restricted
R8290 T9965 T9964 prep of,effect
R8291 T9966 T9967 compound CpG,methylation
R8292 T9967 T9965 pobj methylation,of
R8293 T9968 T9970 auxpass was,restricted
R8294 T9969 T9970 neg not,restricted
R8295 T9970 T9970 ROOT restricted,restricted
R8296 T9971 T9970 prep to,restricted
R8297 T9972 T9973 amod IRF-4-positive,cells
R8298 T9973 T9971 pobj cells,to
R8299 T9974 T9970 punct ",",restricted
R8300 T9975 T9979 mark since,led
R8301 T9976 T9979 prep in,led
R8302 T9977 T9978 amod vitro,methylation
R8303 T9978 T9976 pobj methylation,in
R8304 T9979 T9970 advcl led,restricted
R8305 T9980 T9979 prep to,led
R8306 T9981 T9984 det a,abrogation
R8307 T9982 T9983 nummod 92.9,%
R8308 T9983 T9984 compound %,abrogation
R8309 T9984 T9980 pobj abrogation,to
R8310 T9985 T9984 prep of,abrogation
R8311 T9986 T9987 compound promoter,activity
R8312 T9987 T9985 pobj activity,of
R8313 T9988 T9987 prep in,activity
R8314 T9989 T9991 amod IRF-4-negative,cells
R8315 T9990 T9991 compound Jurkat,cells
R8316 T9991 T9988 pobj cells,in
R8317 T9992 T9994 punct (,5C
R8318 T9993 T9994 compound Figure,5C
R8319 T9994 T9987 appos 5C,activity
R8320 T9995 T9994 punct ),5C
R8321 T9996 T9970 punct .,restricted
R8322 T9997 T10005 prep In,construct
R8323 T9998 T9997 pobj contrast,In
R8324 T9999 T10005 punct ",",construct
R8325 T10000 T10005 nsubj control,construct
R8326 T10001 T10000 dobj methylation,control
R8327 T10002 T10000 prep of,control
R8328 T10003 T10004 det a,reporter
R8329 T10004 T10002 pobj reporter,of
R8330 T10005 T10005 ROOT construct,construct
R8331 T10006 T10005 prep with,construct
R8332 T10007 T10009 det a,promoter
R8333 T10008 T10009 amod different,promoter
R8334 T10009 T10006 pobj promoter,with
R8335 T10010 T10009 punct (,promoter
R8336 T10011 T10009 appos FasL,promoter
R8337 T10012 T10009 punct ),promoter
R8338 T10013 T10015 advmod as,as
R8339 T10014 T10015 advmod well,as
R8340 T10015 T10009 cc as,promoter
R8341 T10016 T10018 det an,vector
R8342 T10017 T10018 amod empty,vector
R8343 T10018 T10009 conj vector,promoter
R8344 T10019 T10005 conj had,construct
R8345 T10020 T10021 det no,effect
R8346 T10021 T10019 dobj effect,had
R8347 T10022 T10021 prep on,effect
R8348 T10023 T10025 det the,activity
R8349 T10024 T10025 compound reporter,activity
R8350 T10025 T10022 pobj activity,on
R8351 T10026 T10027 punct (,data
R8352 T10027 T10025 appos data,activity
R8353 T10028 T10029 neg not,shown
R8354 T10029 T10027 acl shown,data
R8355 T10030 T10027 punct ),data
R8356 T10031 T10005 punct .,construct
R8357 T10032 T10033 det These,data
R8358 T10033 T10034 nsubj data,proved
R8359 T10034 T10034 ROOT proved,proved
R8360 T10035 T10037 det a,association
R8361 T10036 T10037 amod direct,association
R8362 T10037 T10034 dobj association,proved
R8363 T10038 T10037 prep between,association
R8364 T10039 T10038 pobj methylation,between
R8365 T10040 T10039 cc and,methylation
R8366 T10041 T10039 conj activity,methylation
R8367 T10042 T10039 prep of,methylation
R8368 T10043 T10045 det the,promoter
R8369 T10044 T10045 compound IRF-4,promoter
R8370 T10045 T10042 pobj promoter,of
R8371 T10046 T10034 punct .,proved
R8641 T10434 T10435 compound mRNA,expression
R8642 T10435 T10445 nsubjpass expression,associated
R8643 T10436 T10435 prep of,expression
R8644 T10437 T10438 compound DNA,methyltransferases
R8645 T10438 T10436 pobj methyltransferases,of
R8646 T10439 T10438 cc and,methyltransferases
R8647 T10440 T10441 amod methyl-CpG-binding,proteins
R8648 T10441 T10438 conj proteins,methyltransferases
R8649 T10442 T10445 aux may,associated
R8650 T10443 T10445 neg not,associated
R8651 T10444 T10445 auxpass be,associated
R8652 T10445 T10445 ROOT associated,associated
R8653 T10446 T10445 prep with,associated
R8654 T10447 T10449 amod IRF-4,methylation
R8655 T10448 T10449 compound promoter,methylation
R8656 T10449 T10446 pobj methylation,with
R8657 T10450 T10456 mark Since,contribute
R8658 T10451 T10456 nsubj abundance,contribute
R8659 T10452 T10451 prep of,abundance
R8660 T10453 T10452 pobj DNMT,of
R8661 T10454 T10453 cc and,DNMT
R8662 T10455 T10453 conj MBP,DNMT
R8663 T10456 T10467 advcl contribute,studied
R8664 T10457 T10458 aux to,promoter
R8665 T10458 T10459 compound promoter,regulation
R8666 T10459 T10456 dobj regulation,contribute
R8667 T10460 T10459 prep via,regulation
R8668 T10461 T10460 pobj methylation,via
R8669 T10462 T10461 punct (,methylation
R8670 T10463 T10461 appos "25,26,28",methylation
R8671 T10464 T10461 punct ),methylation
R8672 T10465 T10467 punct ",",studied
R8698 T10491 T10493 aux did,detect
R8699 T10492 T10493 neg not,detect
R8700 T10493 T10493 ROOT detect,detect
R8701 T10494 T10496 det a,difference
R8702 T10495 T10496 amod significant,difference
R8703 T10496 T10493 dobj difference,detect
R8704 T10497 T10496 prep in,difference
R8705 T10498 T10497 pobj DNMT,in
R8706 T10499 T10500 punct (,DNMT1
R8707 T10500 T10498 appos DNMT1,DNMT
R8708 T10501 T10500 punct ",",DNMT1
R8709 T10502 T10500 conj DNMT3A,DNMT1
R8710 T10503 T10502 cc and,DNMT3A
R8725 T10518 T10496 conj expression,difference
R8726 T10519 T10518 prep between,expression
R8727 T10520 T10519 pobj IRF-4-positive,between
R8728 T10521 T10520 cc and,IRF-4-positive
R8729 T10522 T10523 punct -,negative
R8730 T10523 T10524 amod negative,cells
R8731 T10524 T10520 conj cells,IRF-4-positive
R8732 T10525 T10526 punct (,Figure
R8733 T10526 T10524 appos Figure,cells
R8734 T10527 T10526 nummod 5D,Figure
R8735 T10528 T10526 punct ),Figure
R8736 T10529 T10493 punct .,detect
R8737 T10530 T10534 prep In,analyzed
R8738 T10531 T10530 pobj fact,In
R8739 T10532 T10534 punct ",",analyzed
R8740 T10533 T10534 nsubj all,analyzed
R8741 T10534 T10534 ROOT analyzed,analyzed
R8742 T10535 T10536 nsubj cells,had
R8743 T10536 T10534 ccomp had,analyzed
R8744 T10537 T10536 dobj moderate,had
R8745 T10538 T10552 prep to,correlated
R8746 T10539 T10541 amod high,levels
R8747 T10540 T10541 compound mRNA,levels
R8748 T10541 T10538 pobj levels,to
R8749 T10542 T10541 prep of,levels
R8750 T10543 T10545 det these,DNMT/MBPs
R8751 T10544 T10545 amod tested,DNMT/MBPs
R8752 T10545 T10542 pobj DNMT/MBPs,of
R8753 T10546 T10545 cc and,DNMT/MBPs
R8754 T10547 T10541 conj differences,levels
R8755 T10548 T10547 prep in,differences
R8756 T10549 T10548 pobj expression,in
R8757 T10550 T10552 auxpass were,correlated
R8758 T10551 T10552 neg not,correlated
R8759 T10552 T10534 conj correlated,analyzed
R8760 T10553 T10552 prep with,correlated
R8761 T10554 T10555 amod IRF-4,status
R8762 T10555 T10553 pobj status,with
R8763 T10556 T10534 punct .,analyzed
R8764 T10557 T10558 det These,results
R8765 T10558 T10559 nsubj results,indicate
R8766 T10559 T10559 ROOT indicate,indicate
R8767 T10560 T10562 det a,cause
R8768 T10561 T10562 amod distinct,cause
R8769 T10562 T10559 dobj cause,indicate
R8770 T10563 T10562 prep of,cause
R8771 T10564 T10566 det the,differences
R8772 T10565 T10566 compound methylation,differences
R8773 T10566 T10563 pobj differences,of
R8774 T10567 T10566 prep in,differences
R8775 T10568 T10572 amod IRF-4-positive,cells
R8776 T10569 T10568 cc and,IRF-4-positive
R8777 T10570 T10571 punct -,negative
R8778 T10571 T10572 amod negative,cells
R8779 T10572 T10567 pobj cells,in
R8780 T10573 T10574 advmod rather,than
R8781 T10574 T10572 cc than,cells
R8782 T10575 T10574 pobj changes,than
R8783 T10576 T10575 prep in,changes
R8784 T10577 T10578 det the,DNMT
R8785 T10578 T10576 pobj DNMT,in
R8786 T10579 T10578 cc and,DNMT
R8787 T10580 T10581 compound MBP,mRNA
R8788 T10581 T10578 conj mRNA,DNMT
R8789 T10582 T10575 conj transcription,changes
R8790 T10583 T10559 punct .,indicate
R10353 T12531 T12533 amod Many,lesions
R10354 T12532 T12533 amod genetic,lesions
R10355 T12533 T12535 nsubjpass lesions,known
R10356 T12534 T12535 auxpass are,known
R10357 T12535 T12535 ROOT known,known
R10358 T12536 T12537 aux to,influence
R10359 T12537 T12535 xcomp influence,known
R10360 T12538 T12539 compound gene,expression
R10361 T12539 T12537 dobj expression,influence
R10362 T12540 T12539 prep of,expression
R10363 T12541 T12543 compound tumor,genes
R10364 T12542 T12543 compound suppressor,genes
R10365 T12543 T12540 pobj genes,of
R10366 T12544 T12535 punct .,known
R10367 T12545 T12551 mark Whereas,have
R10368 T12546 T12551 nsubj mutations,have
R10369 T12547 T12546 cc and,mutations
R10370 T12548 T12546 conj deletions,mutations
R10371 T12549 T12548 cc or,deletions
R10372 T12550 T12548 conj insertions,deletions
R10373 T12551 T12557 advcl have,are
R10374 T12552 T12553 amod permanent,effects
R10375 T12553 T12551 dobj effects,have
R10376 T12554 T12557 punct ",",are
R10377 T12555 T12556 amod reversible,mechanisms
R10378 T12556 T12557 nsubj mechanisms,are
R10379 T12557 T12557 ROOT are,are
R10380 T12558 T12559 compound gene,methylation
R10381 T12559 T12557 attr methylation,are
R10382 T12560 T12559 punct ",",methylation
R10383 T12561 T12559 cc or,methylation
R10384 T12562 T12559 conj expression,methylation
R10385 T12563 T12562 cc and,expression
R10386 T12564 T12562 conj activation,expression
R10387 T12565 T12562 prep of,expression
R10388 T12566 T12567 compound transcription,factors
R10389 T12567 T12565 pobj factors,of
R10390 T12568 T12559 punct ",",methylation
R10391 T12569 T12557 advmod respectively,are
R10392 T12570 T12557 punct .,are
R10393 T12571 T12572 nsubj We,studied
R10394 T12572 T12572 ROOT studied,studied
R10395 T12573 T12575 det a,cause
R10396 T12574 T12575 amod putative,cause
R10397 T12575 T12572 dobj cause,studied
R10398 T12576 T12575 prep for,cause
R10399 T12577 T12579 amod absent,expression
R10400 T12578 T12579 compound IRF-4,expression
R10401 T12579 T12576 pobj expression,for
R10402 T12580 T12579 prep in,expression
R10403 T12581 T12582 compound leukemia,cells
R10404 T12582 T12580 pobj cells,in
R10405 T12583 T12582 cc and,cells
R10406 T12584 T12585 advmod first,focused
R10407 T12585 T12572 conj focused,studied
R10408 T12586 T12585 prep on,focused
R10409 T12587 T12588 amod genetic,aberrations
R10410 T12588 T12586 pobj aberrations,on
R10411 T12589 T12588 prep of,aberrations
R10412 T12590 T12591 det the,promoter
R10413 T12591 T12589 pobj promoter,of
R10414 T12592 T12572 punct .,studied
R10415 T12593 T12594 nsubj We,observed
R10416 T12594 T12594 ROOT observed,observed
R10417 T12595 T12597 det no,alterations
R10418 T12596 T12597 amod genetic,alterations
R10419 T12597 T12594 dobj alterations,observed
R10420 T12598 T12597 prep in,alterations
R10421 T12599 T12601 det the,promoter
R10422 T12600 T12601 compound IRF-4,promoter
R10423 T12601 T12598 pobj promoter,in
R10424 T12602 T12601 punct ",",promoter
R10425 T12603 T12605 nsubj which,account
R10426 T12604 T12605 aux can,account
R10427 T12605 T12601 relcl account,promoter
R10428 T12606 T12605 prep for,account
R10429 T12607 T12608 det the,lack
R10430 T12608 T12606 pobj lack,for
R10431 T12609 T12608 prep of,lack
R10432 T12610 T12611 amod IRF-4,expression
R10433 T12611 T12609 pobj expression,of
R10434 T12612 T12597 punct :,alterations
R10435 T12613 T12617 det The,changes
R10436 T12614 T12617 amod detected,changes
R10437 T12615 T12616 compound base,pair
R10438 T12616 T12617 compound pair,changes
R10439 T12617 T12597 appos changes,alterations
R10440 T12618 T12617 prep at,changes
R10441 T12619 T12618 pobj position,at
R10442 T12620 T12626 nmod −,substitution
R10443 T12621 T12620 nummod 1081,−
R10444 T12622 T12623 punct (,T
R10445 T12623 T12626 dep T,substitution
R10446 T12624 T12626 nummod →,substitution
R10447 T12625 T12626 compound C,substitution
R10448 T12626 T12617 conj substitution,changes
R10449 T12627 T12626 punct ),substitution
R10450 T12628 T12626 punct ",",substitution
R10451 T12629 T12626 prep at,substitution
R10452 T12630 T12631 compound position,−
R10453 T12631 T12629 pobj −,at
R10454 T12632 T12631 nummod 1068,−
R10455 T12633 T12637 punct (,substitution
R10456 T12634 T12637 det A,substitution
R10457 T12635 T12637 compound →,substitution
R10458 T12636 T12637 compound C,substitution
R10459 T12637 T12637 ROOT substitution,substitution
R10460 T12638 T12637 punct ),substitution
R10461 T12639 T12637 cc and,substitution
R10462 T12640 T12650 prep at,are
R10463 T12641 T12640 pobj position,at
R10464 T12642 T12650 nsubj −,are
R10465 T12643 T12642 nummod 116,−
R10466 T12644 T12642 punct (,−
R10467 T12645 T12648 det A,substitution
R10468 T12646 T12648 compound →,substitution
R10469 T12647 T12648 compound C,substitution
R10470 T12648 T12642 appos substitution,−
R10471 T12649 T12642 punct ),−
R10472 T12650 T12637 conj are,substitution
R10473 T12651 T12652 amod unlikely,responsible
R10474 T12652 T12650 acomp responsible,are
R10475 T12653 T12652 prep for,responsible
R10476 T12654 T12655 amod absent,IRF-4-expression
R10477 T12655 T12653 pobj IRF-4-expression,for
R10478 T12656 T12662 mark since,found
R10479 T12657 T12660 det the,mutations
R10480 T12658 T12660 amod first,mutations
R10481 T12659 T12660 nummod two,mutations
R10482 T12660 T12662 nsubjpass mutations,found
R10483 T12661 T12662 auxpass were,found
R10484 T12662 T12650 advcl found,are
R10485 T12663 T12664 advmod both,in
R10486 T12664 T12662 prep in,found
R10487 T12665 T12669 amod IRF-4-positive,cells
R10488 T12666 T12665 cc and,IRF-4-positive
R10489 T12667 T12665 punct -,IRF-4-positive
R10490 T12668 T12669 amod negative,cells
R10491 T12669 T12664 pobj cells,in
R10492 T12670 T12676 mark whereas,detected
R10493 T12671 T12673 det the,change
R10494 T12672 T12673 amod latter,change
R10495 T12673 T12676 nsubjpass change,detected
R10496 T12674 T12676 auxpass was,detected
R10497 T12675 T12676 neg not,detected
R10498 T12676 T12650 advcl detected,are
R10499 T12677 T12676 advmod consistently,detected
R10500 T12678 T12676 prep in,detected
R10501 T12679 T12680 advmod all,IRF-4-negative
R10502 T12680 T12678 pobj IRF-4-negative,in
R10503 T12681 T12680 cc or,IRF-4-negative
R10504 T12682 T12683 punct -,positive
R10505 T12683 T12684 amod positive,cells
R10506 T12684 T12680 conj cells,IRF-4-negative
R10507 T12685 T12650 cc and,are
R10508 T12686 T12688 aux may,be
R10509 T12687 T12688 advmod thus,be
R10510 T12688 T12650 conj be,are
R10511 T12689 T12690 det a,polymorphism
R10512 T12690 T12688 attr polymorphism,be
R10513 T12691 T12637 punct .,substitution
R10514 T12692 T12694 det All,substitutions
R10515 T12693 T12694 nummod three,substitutions
R10516 T12694 T12697 nsubj substitutions,change
R10517 T12695 T12697 aux did,change
R10518 T12696 T12697 neg not,change
R10519 T12697 T12697 ROOT change,change
R10520 T12698 T12702 det any,factor
R10521 T12699 T12702 amod known,factor
R10522 T12700 T12702 amod putative,factor
R10523 T12701 T12702 compound transcription,factor
R10524 T12702 T12697 dobj factor,change
R10525 T12703 T12704 amod binding,sites
R10526 T12704 T12697 dobj sites,change
R10527 T12705 T12704 punct (,sites
R10528 T12706 T12704 appos "30,31",sites
R10529 T12707 T12704 punct ),sites
R10530 T12708 T12697 cc and,change
R10531 T12709 T12712 advmod also,affect
R10532 T12710 T12712 aux do,affect
R10533 T12711 T12712 neg not,affect
R10534 T12712 T12697 conj affect,change
R10535 T12713 T12715 det any,sites
R10536 T12714 T12715 compound restriction,sites
R10537 T12715 T12712 dobj sites,affect
R10538 T12716 T12715 cc or,sites
R10539 T12717 T12719 amod primer,sites
R10540 T12718 T12719 amod binding,sites
R10541 T12719 T12715 conj sites,sites
R10542 T12720 T12719 prep of,sites
R10543 T12721 T12723 det the,assays
R10544 T12722 T12723 amod used,assays
R10545 T12723 T12720 pobj assays,of
R10546 T12724 T12697 punct .,change
R10547 T12725 T12747 advmod However,excluded
R10548 T12726 T12747 punct ",",excluded
R10549 T12727 T12729 amod permanent,variations
R10550 T12728 T12729 amod genetic,variations
R10551 T12729 T12747 nsubjpass variations,excluded
R10552 T12730 T12729 prep in,variations
R10553 T12731 T12734 det the,sequence
R10554 T12732 T12734 amod IRF-4,sequence
R10555 T12733 T12734 amod coding,sequence
R10556 T12734 T12730 pobj sequence,in
R10557 T12735 T12734 punct ",",sequence
R10558 T12736 T12737 amod such,as
R10559 T12737 T12734 prep as,sequence
R10560 T12738 T12737 pobj deletions,as
R10561 T12739 T12738 cc or,deletions
R10562 T12740 T12738 conj mutations,deletions
R10563 T12741 T12738 acl resulting,deletions
R10564 T12742 T12741 prep in,resulting
R10565 T12743 T12742 pobj stop-codons,in
R10566 T12744 T12747 aux have,excluded
R10567 T12745 T12747 neg not,excluded
R10568 T12746 T12747 auxpass been,excluded
R10569 T12747 T12747 ROOT excluded,excluded
R10570 T12748 T12747 agent by,excluded
R10571 T12749 T12750 compound sequence,analysis
R10572 T12750 T12748 pobj analysis,by
R10573 T12751 T12747 punct .,excluded
R10574 T12752 T12762 prep Since,induced
R10575 T12753 T12754 compound IRF-4,expression
R10576 T12754 T12752 pobj expression,Since
R10577 T12755 T12754 prep in,expression
R10578 T12756 T12757 compound cell,lines
R10579 T12757 T12755 pobj lines,in
R10580 T12758 T12754 cc and,expression
R10581 T12759 T12762 nsubjpass CML,induced
R10582 T12760 T12762 aux can,induced
R10583 T12761 T12762 auxpass be,induced
R10584 T12762 T12781 advcl induced,seems
R10585 T12763 T12762 agent by,induced
R10586 T12764 T12763 pobj demethylation,by
R10587 T12765 T12764 cc and,demethylation
R10588 T12766 T12768 amod successful,therapy
R10589 T12767 T12768 compound IFN-α,therapy
R10590 T12768 T12764 conj therapy,demethylation
R10591 T12769 T12770 punct (,3
R10592 T12770 T12768 parataxis 3,therapy
R10593 T12771 T12770 punct ),3
R10594 T12772 T12770 punct ",",3
R10595 T12773 T12781 advmod respectively,seems
R10596 T12774 T12781 punct ",",seems
R10597 T12775 T12776 det the,existence
R10598 T12776 T12781 nsubj existence,seems
R10599 T12777 T12776 prep of,existence
R10600 T12778 T12780 amod such,aberrations
R10601 T12779 T12780 amod genetic,aberrations
R10602 T12780 T12777 pobj aberrations,of
R10603 T12781 T12781 ROOT seems,seems
R10604 T12782 T12781 oprd unlikely,seems
R10605 T12783 T12781 punct .,seems
R10606 T12784 T12786 nsubj We,investigated
R10607 T12785 T12786 advmod then,investigated
R10608 T12786 T12786 ROOT investigated,investigated
R10609 T12787 T12799 mark whether,was
R10610 T12788 T12791 det the,down-regulation
R10611 T12789 T12790 advmod previously,described
R10612 T12790 T12791 amod described,down-regulation
R10613 T12791 T12799 nsubj down-regulation,was
R10614 T12792 T12791 prep of,down-regulation
R10615 T12793 T12794 compound IRF-4,expression
R10616 T12794 T12792 pobj expression,of
R10617 T12795 T12791 prep in,down-regulation
R10618 T12796 T12798 amod human,leukemias
R10619 T12797 T12798 amod myeloid,leukemias
R10620 T12798 T12795 pobj leukemias,in
R10621 T12799 T12786 ccomp was,investigated
R10622 T12800 T12799 acomp due,was
R10623 T12801 T12800 prep to,due
R10624 T12802 T12804 det a,hypermethylation
R10625 T12803 T12804 compound differential,hypermethylation
R10626 T12804 T12801 pobj hypermethylation,to
R10627 T12805 T12804 prep of,hypermethylation
R10628 T12806 T12807 det the,promoter
R10629 T12807 T12805 pobj promoter,of
R10630 T12808 T12799 punct ",",was
R10631 T12809 T12818 mark since,be
R10632 T12810 T12812 det the,re-expression
R10633 T12811 T12812 amod presented,re-expression
R10634 T12812 T12818 nsubj re-expression,be
R10635 T12813 T12812 amod due,re-expression
R10636 T12814 T12813 prep to,due
R10637 T12815 T12814 pobj AzadC-treatment,to
R10638 T12816 T12818 aux might,be
R10639 T12817 T12818 advmod also,be
R10640 T12818 T12799 advcl be,was
R10641 T12819 T12820 det a,result
R10642 T12820 T12818 attr result,be
R10643 T12821 T12820 prep of,result
R10644 T12822 T12821 pobj activation,of
R10645 T12823 T12822 prep of,activation
R10646 T12824 T12826 amod positive,regulators
R10647 T12825 T12826 amod transcriptional,regulators
R10648 T12826 T12823 pobj regulators,of
R10649 T12827 T12826 prep of,regulators
R10650 T12828 T12827 pobj IRF-4,of
R10651 T12829 T12786 punct .,investigated
R10652 T12830 T12834 nsubj Methylation,is
R10653 T12831 T12830 prep of,Methylation
R10654 T12832 T12833 compound CpG,sites
R10655 T12833 T12831 pobj sites,of
R10656 T12834 T12834 ROOT is,is
R10657 T12835 T12837 det a,mechanism
R10658 T12836 T12837 amod common,mechanism
R10659 T12837 T12834 attr mechanism,is
R10660 T12838 T12837 prep of,mechanism
R10661 T12839 T12838 pcomp silencing,of
R10662 T12840 T12839 dobj genes,silencing
R10663 T12841 T12839 prep in,silencing
R10664 T12842 T12841 pobj leukemia,in
R10665 T12843 T12834 cc and,is
R10666 T12844 T12847 aux has,shown
R10667 T12845 T12847 advmod also,shown
R10668 T12846 T12847 auxpass been,shown
R10669 T12847 T12834 conj shown,is
R10670 T12848 T12847 prep for,shown
R10671 T12849 T12850 det another,IRF
R10672 T12850 T12848 pobj IRF,for
R10673 T12851 T12850 punct ",",IRF
R10674 T12852 T12850 conj IRF-7,IRF
R10675 T12853 T12852 punct (,IRF-7
R10676 T12854 T12852 appos 35,IRF-7
R10677 T12855 T12852 punct ),IRF-7
R10678 T12856 T12848 cc and,for
R10679 T12857 T12848 conj for,for
R10680 T12858 T12857 pobj PU,for
R10681 T12859 T12858 nummod .1,PU
R10682 T12860 T12858 punct (,PU
R10683 T12861 T12858 nummod 36,PU
R10684 T12862 T12858 punct ),PU
R10685 T12863 T12847 punct ",",shown
R10686 T12864 T12866 det an,partner
R10687 T12865 T12866 amod interacting,partner
R10688 T12866 T12847 dobj partner,shown
R10689 T12867 T12866 prep of,partner
R10690 T12868 T12867 pobj IRF-4,of
R10691 T12869 T12834 punct .,is
R10692 T12870 T12871 aux To,elucidate
R10693 T12871 T12888 advcl elucidate,treated
R10694 T12872 T12873 det the,relevance
R10695 T12873 T12871 dobj relevance,elucidate
R10696 T12874 T12873 prep of,relevance
R10697 T12875 T12876 det this,mechanism
R10698 T12876 T12874 pobj mechanism,of
R10699 T12877 T12873 prep for,relevance
R10700 T12878 T12879 det the,regulation
R10701 T12879 T12877 pobj regulation,for
R10702 T12880 T12879 prep of,regulation
R10703 T12881 T12882 compound IRF-4,expression
R10704 T12882 T12880 pobj expression,of
R10705 T12883 T12888 punct ",",treated
R10706 T12884 T12886 amod various,cells
R10707 T12885 T12886 amod leukemic,cells
R10708 T12886 T12888 nsubjpass cells,treated
R10709 T12887 T12888 auxpass were,treated
R10710 T12888 T12888 ROOT treated,treated
R10711 T12889 T12888 prep with,treated
R10712 T12890 T12891 amod demethylating,agents
R10713 T12891 T12889 pobj agents,with
R10714 T12892 T12891 cc and,agents
R10715 T12893 T12891 conj promoters,agents
R10716 T12894 T12895 auxpass were,sequenced
R10717 T12895 T12895 ROOT sequenced,sequenced
R10718 T12896 T12895 prep after,sequenced
R10719 T12897 T12898 amod bisulfite,treatment
R10720 T12898 T12896 pobj treatment,after
R10721 T12899 T12895 punct .,sequenced
R10722 T12900 T12901 nsubj We,found
R10723 T12901 T12901 ROOT found,found
R10724 T12902 T12908 mark that,connected
R10725 T12903 T12904 amod IRF-4,expression
R10726 T12904 T12908 nsubjpass expression,connected
R10727 T12905 T12908 aux could,connected
R10728 T12906 T12908 advmod indeed,connected
R10729 T12907 T12908 auxpass be,connected
R10730 T12908 T12901 ccomp connected,found
R10731 T12909 T12908 prep to,connected
R10732 T12910 T12912 det the,status
R10733 T12911 T12912 amod methylation,status
R10734 T12912 T12909 pobj status,to
R10735 T12913 T12912 prep of,status
R10736 T12914 T12916 amod distinct,motifs
R10737 T12915 T12916 compound CpG,motifs
R10738 T12916 T12913 pobj motifs,of
R10739 T12917 T12912 prep in,status
R10740 T12918 T12920 det the,promoter
R10741 T12919 T12920 compound IRF-4,promoter
R10742 T12920 T12917 pobj promoter,in
R10743 T12921 T12901 punct .,found
R10744 T12922 T12930 prep In,shown
R10745 T12923 T12924 compound Figure,4A
R10746 T12924 T12922 pobj 4A,In
R10747 T12925 T12930 punct ",",shown
R10748 T12926 T12928 det those,sites
R10749 T12927 T12928 compound CpG,sites
R10750 T12928 T12930 nsubjpass sites,shown
R10751 T12929 T12930 auxpass are,shown
R10752 T12930 T12930 ROOT shown,shown
R10753 T12931 T12930 punct (,shown
R10754 T12932 T12933 amod bottom,line
R10755 T12933 T12930 dobj line,shown
R10756 T12934 T12930 punct ),shown
R10757 T12935 T12930 punct ",",shown
R10758 T12936 T12937 poss whose,hypermethylation
R10759 T12937 T12939 nsubj hypermethylation,account
R10760 T12938 T12939 aux may,account
R10761 T12939 T12930 ccomp account,shown
R10762 T12940 T12939 prep for,account
R10763 T12941 T12942 det the,absence
R10764 T12942 T12940 pobj absence,for
R10765 T12943 T12942 prep of,absence
R10766 T12944 T12945 compound IRF-4,expression
R10767 T12945 T12943 pobj expression,of
R10768 T12946 T12942 prep in,absence
R10769 T12947 T12949 det the,cells
R10770 T12948 T12949 amod respective,cells
R10771 T12949 T12946 pobj cells,in
R10772 T12950 T12930 punct .,shown
R10773 T12951 T12958 nsubj One,is
R10774 T12952 T12951 prep of,One
R10775 T12953 T12952 pobj them,of
R10776 T12954 T12953 punct (,them
R10777 T12955 T12956 nmod #,54
R10778 T12956 T12953 appos 54,them
R10779 T12957 T12951 punct ),One
R10780 T12958 T12958 ROOT is,is
R10781 T12959 T12958 acomp adjacent,is
R10782 T12960 T12959 prep to,adjacent
R10783 T12961 T12964 det an,element
R10784 T12962 T12964 amod identified,element
R10785 T12963 T12964 amod regulatory,element
R10786 T12964 T12960 pobj element,to
R10787 T12965 T12966 punct (,NFκB-site
R10788 T12966 T12964 appos NFκB-site,element
R10789 T12967 T12958 punct ),is
R10790 T12968 T12958 punct ",",is
R10791 T12969 T12958 advcl indicating,is
R10792 T12970 T12972 det a,involvement
R10793 T12971 T12972 amod possible,involvement
R10794 T12972 T12969 dobj involvement,indicating
R10795 T12973 T12972 prep of,involvement
R10796 T12974 T12975 det this,site
R10797 T12975 T12973 pobj site,of
R10798 T12976 T12958 punct .,is
R10799 T12977 T12993 prep At,was
R10800 T12978 T12981 nummod two,sites
R10801 T12979 T12981 amod further,sites
R10802 T12980 T12981 compound CpG,sites
R10803 T12981 T12977 pobj sites,At
R10804 T12982 T12981 punct (,sites
R10805 T12983 T12993 meta #,was
R10806 T12984 T12983 nummod 48,#
R10807 T12985 T12983 punct ",",#
R10808 T12986 T12983 appos 45,#
R10809 T12987 T12983 punct ),#
R10810 T12988 T12990 det the,status
R10811 T12989 T12990 compound methylation,status
R10812 T12990 T12993 nsubj status,was
R10813 T12991 T12990 prep in,status
R10814 T12992 T12991 pobj IRF-4-positive,in
R10815 T12993 T12993 ROOT was,was
R10816 T12994 T12993 acomp lower,was
R10817 T12995 T12994 prep than,lower
R10818 T12996 T12995 pobj that,than
R10819 T12997 T12996 prep of,that
R10820 T12998 T12999 amod IRF-4-negative,cells
R10821 T12999 T12997 pobj cells,of
R10822 T13000 T12993 punct .,was
R10823 T13001 T13003 det These,sites
R10824 T13002 T13003 compound CpG,sites
R10825 T13003 T13005 nsubjpass sites,located
R10826 T13004 T13005 auxpass are,located
R10827 T13005 T13005 ROOT located,located
R10828 T13006 T13005 prep in,located
R10829 T13007 T13008 det an,NFκB
R10830 T13008 T13006 pobj NFκB,in
R10831 T13009 T13005 cc and,located
R10832 T13010 T13012 det an,element
R10833 T13011 T13012 nummod SP1,element
R10834 T13012 T13005 conj element,located
R10835 T13013 T13012 punct (,element
R10836 T13014 T13012 appos 31,element
R10837 T13015 T13012 punct ),element
R10838 T13016 T13005 cc and,located
R10839 T13017 T13020 advmod thus,play
R10840 T13018 T13020 aux may,play
R10841 T13019 T13020 advmod also,play
R10842 T13020 T13005 conj play,located
R10843 T13021 T13022 det a,role
R10844 T13022 T13020 dobj role,play
R10845 T13023 T13022 prep in,role
R10846 T13024 T13023 pobj regulation,in
R10847 T13025 T13024 prep of,regulation
R10848 T13026 T13027 amod IRF-4,expression
R10849 T13027 T13025 pobj expression,of
R10850 T13028 T13005 punct .,located
R10851 T13029 T13032 nsubjpass It,shown
R10852 T13030 T13032 aux has,shown
R10853 T13031 T13032 auxpass been,shown
R10854 T13032 T13032 ROOT shown,shown
R10855 T13033 T13036 mark that,play
R10856 T13034 T13035 compound NFκB,elements
R10857 T13035 T13036 nsubj elements,play
R10858 T13036 T13032 ccomp play,shown
R10859 T13037 T13039 det an,role
R10860 T13038 T13039 amod important,role
R10861 T13039 T13036 dobj role,play
R10862 T13040 T13039 prep in,role
R10863 T13041 T13042 compound IRF-4,induction
R10864 T13042 T13040 pobj induction,in
R10865 T13043 T13046 mark as,depends
R10866 T13044 T13045 amod IRF-4,expression
R10867 T13045 T13046 nsubj expression,depends
R10868 T13046 T13036 advcl depends,play
R10869 T13047 T13046 prep on,depends
R10870 T13048 T13047 pobj binding,on
R10871 T13049 T13048 prep of,binding
R10872 T13050 T13052 det the,c-Rel
R10873 T13051 T13052 compound transactivator,c-Rel
R10874 T13052 T13049 pobj c-Rel,of
R10875 T13053 T13052 prep to,c-Rel
R10876 T13054 T13055 det these,elements
R10877 T13055 T13053 pobj elements,to
R10878 T13056 T13055 prep in,elements
R10879 T13057 T13059 det the,promoter
R10880 T13058 T13059 compound IRF-4,promoter
R10881 T13059 T13056 pobj promoter,in
R10882 T13060 T13059 punct (,promoter
R10883 T13061 T13059 appos "31,37",promoter
R10884 T13062 T13059 punct ),promoter
R10885 T13063 T13032 punct .,shown
R10886 T13064 T13075 advmod Furthermore,inhibits
R10887 T13065 T13075 punct ",",inhibits
R10888 T13066 T13075 nsubj methylation,inhibits
R10889 T13067 T13066 prep of,methylation
R10890 T13068 T13070 det the,CpG
R10891 T13069 T13070 amod central,CpG
R10892 T13070 T13067 pobj CpG,of
R10893 T13071 T13066 prep in,methylation
R10894 T13072 T13074 det the,element
R10895 T13073 T13074 compound NFκB,element
R10896 T13074 T13071 pobj element,in
R10897 T13075 T13075 ROOT inhibits,inhibits
R10898 T13076 T13075 dobj binding,inhibits
R10899 T13077 T13076 prep of,binding
R10900 T13078 T13081 det the,complexes
R10901 T13079 T13080 compound NFκB,protein
R10902 T13080 T13081 compound protein,complexes
R10903 T13081 T13077 pobj complexes,of
R10904 T13082 T13081 punct (,complexes
R10905 T13083 T13081 appos 38,complexes
R10906 T13084 T13081 punct ),complexes
R10907 T13085 T13075 punct ",",inhibits
R10908 T13086 T13075 advcl promoting,inhibits
R10909 T13087 T13088 det the,significance
R10910 T13088 T13086 dobj significance,promoting
R10911 T13089 T13088 prep of,significance
R10912 T13090 T13093 det the,differences
R10913 T13091 T13093 amod observed,differences
R10914 T13092 T13093 compound methylation,differences
R10915 T13093 T13089 pobj differences,of
R10916 T13094 T13093 prep in,differences
R10917 T13095 T13094 pobj IRF-4-positive,in
R10918 T13096 T13088 cc and,significance
R10919 T13097 T13098 punct -,negative
R10920 T13098 T13099 amod negative,cells
R10921 T13099 T13088 conj cells,significance
R10922 T13100 T13075 punct .,inhibits
R10923 T13101 T13112 npadvmod Via,appoint
R10924 T13102 T13112 prep in,appoint
R10925 T13103 T13104 amod vitro,methylation
R10926 T13104 T13102 pobj methylation,in
R10927 T13105 T13104 cc and,methylation
R10928 T13106 T13107 compound reporter,gene
R10929 T13107 T13108 compound gene,assays
R10930 T13108 T13102 pobj assays,in
R10931 T13109 T13112 nsubj we,appoint
R10932 T13110 T13112 aux could,appoint
R10933 T13111 T13112 advmod clearly,appoint
R10934 T13112 T13112 ROOT appoint,appoint
R10935 T13113 T13114 det the,silencing
R10936 T13114 T13112 dobj silencing,appoint
R10937 T13115 T13114 prep of,silencing
R10938 T13116 T13118 det the,promoter
R10939 T13117 T13118 compound IRF-4,promoter
R10940 T13118 T13115 pobj promoter,of
R10941 T13119 T13112 prep to,appoint
R10942 T13120 T13122 det a,effect
R10943 T13121 T13122 compound methylation,effect
R10944 T13122 T13119 pobj effect,to
R10945 T13123 T13122 punct ",",effect
R10946 T13124 T13127 nsubj which,be
R10947 T13125 T13127 aux may,be
R10948 T13126 T13127 advmod thus,be
R10949 T13127 T13122 relcl be,effect
R10950 T13128 T13129 det the,mechanism
R10951 T13129 T13127 attr mechanism,be
R10952 T13130 T13129 prep of,mechanism
R10953 T13131 T13132 compound IRF-4,deregulation
R10954 T13132 T13130 pobj deregulation,of
R10955 T13133 T13132 prep in,deregulation
R10956 T13134 T13133 pobj vivo,in
R10957 T13135 T13112 punct .,appoint
R10958 T13136 T13138 nummod One,cause
R10959 T13137 T13138 amod possible,cause
R10960 T13138 T13145 nsubj cause,is
R10961 T13139 T13138 prep for,cause
R10962 T13140 T13142 det the,methylation
R10963 T13141 T13142 amod aberrant,methylation
R10964 T13142 T13139 pobj methylation,for
R10965 T13143 T13142 prep in,methylation
R10966 T13144 T13143 pobj tumorigenesis,in
R10967 T13145 T13145 ROOT is,is
R10968 T13146 T13148 det an,level
R10969 T13147 T13148 amod increased,level
R10970 T13148 T13145 attr level,is
R10971 T13149 T13148 prep of,level
R10972 T13150 T13149 pobj DNMTs,of
R10973 T13151 T13148 prep during,level
R10974 T13152 T13154 det the,process
R10975 T13153 T13154 amod pathogenetic,process
R10976 T13154 T13151 pobj process,during
R10977 T13155 T13145 punct .,is
R10978 T13156 T13174 prep In,detected
R10979 T13157 T13156 pobj colon,In
R10980 T13158 T13157 punct ",",colon
R10981 T13159 T13157 conj lung,colon
R10982 T13160 T13159 cc and,lung
R10983 T13161 T13162 amod hematologic,malignancies
R10984 T13162 T13159 conj malignancies,lung
R10985 T13163 T13157 punct ",",colon
R10986 T13164 T13174 nsubj overexpression,detected
R10987 T13165 T13164 prep of,overexpression
R10988 T13166 T13165 pobj DNMT1,of
R10989 T13167 T13166 punct ",",DNMT1
R10990 T13168 T13170 det a,DNMT
R10991 T13199 T13200 amod known,DNMTs
R10992 T13169 T13170 compound maintenance,DNMT
R10993 T13200 T13196 pobj DNMTs,of
R10994 T13201 T13193 punct ",",exhibited
R10995 T13170 T13166 appos DNMT,DNMT1
R10996 T13202 T13208 mark while,expressed
R10997 T13203 T13204 compound CML,cells
R10998 T13171 T13174 punct ",",detected
R10999 T13204 T13208 nsubj cells,expressed
R11000 T13205 T13204 prep in,cells
R11001 T13206 T13207 amod chronic,phase
R11002 T13172 T13174 aux has,detected
R11003 T13207 T13205 pobj phase,in
R11004 T13208 T13193 advcl expressed,exhibited
R11005 T13209 T13210 amod normal,levels
R11006 T13173 T13174 auxpass been,detected
R11007 T13210 T13208 dobj levels,expressed
R11008 T13211 T13210 prep of,levels
R11009 T13212 T13211 pobj DNMTs,of
R11010 T13174 T13174 ROOT detected,detected
R11011 T13213 T13214 mark if,compared
R11012 T13214 T13208 advcl compared,expressed
R11013 T13215 T13214 prep with,compared
R11014 T13175 T13174 punct (,detected
R11015 T13216 T13219 amod normal,cells
R11016 T13217 T13218 compound bone,marrow
R11017 T13218 T13219 compound marrow,cells
R11018 T13219 T13215 pobj cells,with
R11019 T13220 T13221 punct (,25
R11020 T13176 T13177 nummod 39,41
R11021 T13221 T13219 appos 25,cells
R11022 T13222 T13219 punct ),cells
R11023 T13223 T13185 punct .,shown
R11024 T13177 T13174 npadvmod 41,detected
R11025 T13224 T13239 advmod Interestingly,detected
R11026 T13225 T13239 punct ",",detected
R11027 T13226 T13228 det a,correlation
R11028 T13178 T13174 punct ),detected
R11029 T13227 T13228 amod positive,correlation
R11030 T13179 T13174 punct .,detected
R11031 T13228 T13239 nsubjpass correlation,detected
R11032 T13229 T13228 prep between,correlation
R11033 T13230 T13232 nummod DNMT1,levels
R11034 T13231 T13232 compound expression,levels
R11035 T13232 T13229 pobj levels,between
R11036 T13180 T13185 advmod Furthermore,shown
R11037 T13233 T13232 cc and,levels
R11038 T13181 T13185 punct ",",shown
R11039 T13182 T13185 nsubjpass it,shown
R11040 T13234 T13232 conj hypermethylation,levels
R11041 T13235 T13234 prep of,hypermethylation
R11042 T13183 T13185 aux has,shown
R11043 T13236 T13235 pobj p15INK4b,of
R11044 T13237 T13239 aux has,detected
R11045 T13238 T13239 auxpass been,detected
R11046 T13184 T13185 auxpass been,shown
R11047 T13239 T13239 ROOT detected,detected
R11048 T13240 T13239 prep in,detected
R11049 T13241 T13240 pobj AML,in
R11050 T13185 T13185 ROOT shown,shown
R11051 T13242 T13243 punct (,25
R11052 T13243 T13239 npadvmod 25,detected
R11053 T13244 T13243 punct ),25
R11054 T13186 T13193 mark that,exhibited
R11055 T13245 T13239 punct .,detected
R11056 T13246 T13253 prep In,detect
R11057 T13247 T13248 det this,work
R11058 T13187 T13188 compound CML,cells
R11059 T13248 T13246 pobj work,In
R11060 T13249 T13253 punct ",",detect
R11061 T13188 T13193 nsubj cells,exhibited
R11062 T13250 T13253 nsubj we,detect
R11063 T13251 T13253 aux did,detect
R11064 T13252 T13253 neg not,detect
R11065 T13189 T13188 prep in,cells
R11066 T13253 T13253 ROOT detect,detect
R11067 T13254 T13257 amod significant,differences
R11068 T13255 T13256 compound mRNA,expression
R11069 T13256 T13257 compound expression,differences
R11070 T13257 T13253 dobj differences,detect
R11071 T13258 T13257 prep of,differences
R11072 T13190 T13192 det the,phase
R11073 T13259 T13260 amod selected,DNMT
R11074 T13260 T13258 pobj DNMT,of
R11075 T13261 T13260 cc or,DNMT
R11076 T13191 T13192 amod acute,phase
R11077 T13262 T13260 conj MBP,DNMT
R11078 T13263 T13253 punct ",",detect
R11079 T13192 T13189 pobj phase,in
R11080 T13264 T13253 advcl making,detect
R11081 T13265 T13268 nsubj it,cause
R11082 T13193 T13185 ccomp exhibited,shown
R11083 T13266 T13268 det an,cause
R11084 T13267 T13268 amod unlikely,cause
R11085 T13268 T13264 ccomp cause,making
R11086 T13194 T13195 amod elevated,levels
R11087 T13269 T13268 prep for,cause
R11088 T13270 T13272 det the,methylation
R11089 T13271 T13272 amod observed,methylation
R11090 T13195 T13193 dobj levels,exhibited
R11091 T13272 T13269 pobj methylation,for
R11092 T13273 T13269 cc and,for
R11093 T13196 T13195 prep of,levels
R11094 T13274 T13277 advmod thus,differences
R11095 T13275 T13277 amod IRF-4,differences
R11096 T13276 T13277 compound expression,differences
R11097 T13277 T13268 dep differences,cause
R11098 T13197 T13200 det the,DNMTs
R11099 T13278 T13277 prep in,differences
R11100 T13279 T13280 compound leukemia,cells
R11101 T13280 T13278 pobj cells,in
R11102 T13198 T13200 nummod three,DNMTs
R11103 T13281 T13253 punct .,detect
R11104 T13282 T13283 det The,finding
R11105 T13296 T13297 nsubj that,accounts
R11106 T13283 T13293 nsubj finding,represent
R11107 T13284 T13288 mark that,silenced
R11108 T13297 T13295 relcl accounts,mechanism
R11109 T13285 T13286 compound IRF-4,expression
R11110 T13286 T13288 nsubjpass expression,silenced
R11111 T13287 T13288 auxpass is,silenced
R11112 T13298 T13297 prep for,accounts
R11113 T13288 T13283 acl silenced,finding
R11114 T13289 T13288 agent by,silenced
R11115 T13290 T13291 compound promoter,hypermethylation
R11116 T13291 T13289 pobj hypermethylation,by
R11117 T13292 T13293 aux might,represent
R11118 T13293 T13293 ROOT represent,represent
R11119 T13294 T13295 det a,mechanism
R11120 T13299 T13302 det the,loss
R11121 T13295 T13293 dobj mechanism,represent
R11122 T13300 T13301 advmod previously,observed
R11123 T13301 T13302 amod observed,loss
R11124 T13302 T13298 pobj loss,for
R11125 T13303 T13302 prep of,loss
R11126 T13304 T13305 compound IRF-4,expression
R11127 T13305 T13303 pobj expression,of
R11128 T13306 T13302 prep in,loss
R11129 T13307 T13306 pobj CML,in
R11130 T13393 T13379 prep by,reverted
R11131 T13394 T13393 pobj treatment,by
R11132 T13308 T13293 punct .,represent
R11133 T13395 T13379 prep with,reverted
R11134 T13396 T13395 pobj AzadC,with
R11135 T13397 T13398 punct (,Figure
R11136 T13309 T13322 advmod Indeed,demonstrated
R11137 T13398 T13396 appos Figure,AzadC
R11138 T13399 T13398 nummod 6,Figure
R11139 T13310 T13322 punct ",",demonstrated
R11140 T13400 T13398 punct ),Figure
R11141 T13401 T13396 cc and,AzadC
R11142 T13311 T13313 amod several,trials
R11143 T13402 T13396 conj AzadC,AzadC
R11144 T13403 T13379 conj has,reverted
R11145 T13312 T13313 amod clinical,trials
R11146 T13404 T13405 det no,effect
R11147 T13405 T13403 dobj effect,has
R11148 T13406 T13405 prep on,effect
R11149 T13313 T13322 nsubj trials,demonstrated
R11150 T13407 T13408 compound ICSBP,levels
R11151 T13408 T13406 pobj levels,on
R11152 T13409 T13408 prep in,levels
R11153 T13410 T13412 amod ICSBP-positive,cells
R11154 T13411 T13412 compound U-937,cells
R11155 T13314 T13313 prep with,trials
R11156 T13412 T13409 pobj cells,in
R11157 T13413 T13414 punct (,Figure
R11158 T13414 T13412 appos Figure,cells
R11159 T13315 T13316 compound leukemia,patients
R11160 T13415 T13414 nummod 6,Figure
R11161 T13416 T13414 punct ),Figure
R11162 T13417 T13379 punct .,reverted
R11163 T13316 T13314 pobj patients,with
R11164 T13418 T13419 det These,data
R11165 T13419 T13420 nsubj data,suggest
R11166 T13420 T13420 ROOT suggest,suggest
R11167 T13421 T13424 det a,mechanism
R11168 T13422 T13424 amod distinct,mechanism
R11169 T13423 T13424 amod regulatory,mechanism
R11170 T13317 T13316 cc and,patients
R11171 T13424 T13420 dobj mechanism,suggest
R11172 T13425 T13424 prep for,mechanism
R11173 T13426 T13428 det these,IRFs
R11174 T13318 T13316 conj patients,patients
R11175 T13427 T13428 nummod two,IRFs
R11176 T13428 T13425 pobj IRFs,for
R11177 T13429 T13420 punct .,suggest
R11178 T13430 T13448 nsubj IRF-4,be
R11179 T13319 T13318 prep with,patients
R11180 T13431 T13430 punct ",",IRF-4
R11181 T13432 T13430 amod similar,IRF-4
R11182 T13433 T13432 prep to,similar
R11183 T13320 T13321 amod myelodysplastic,syndromes
R11184 T13434 T13439 amod many,genes
R11185 T13435 T13439 amod other,genes
R11186 T13321 T13319 pobj syndromes,with
R11187 T13436 T13439 amod classical,genes
R11188 T13437 T13438 compound tumor,suppressor
R11189 T13438 T13439 compound suppressor,genes
R11190 T13322 T13322 ROOT demonstrated,demonstrated
R11191 T13439 T13433 pobj genes,to
R11192 T13440 T13439 appos p15INK4b,genes
R11193 T13441 T13440 punct ",",p15INK4b
R11194 T13323 T13326 det the,benefit
R11195 T13442 T13440 conj p16INK4a,p15INK4b
R11196 T13443 T13442 cc or,p16INK4a
R11197 T13444 T13442 conj p53,p16INK4a
R11198 T13324 T13326 amod potential,benefit
R11199 T13445 T13448 punct ",",be
R11200 T13446 T13448 aux may,be
R11201 T13325 T13326 amod clinical,benefit
R11202 T13447 T13448 advmod thus,be
R11203 T13448 T13448 ROOT be,be
R11204 T13449 T13450 det a,subject
R11205 T13326 T13322 dobj benefit,demonstrated
R11206 T13450 T13448 attr subject,be
R11207 T13451 T13450 prep of,subject
R11208 T13452 T13451 pobj alterations,of
R11209 T13327 T13326 prep of,benefit
R11210 T13453 T13452 prep in,alterations
R11211 T13454 T13457 det the,status
R11212 T13455 T13457 compound promoter,status
R11213 T13328 T13329 det a,treatment
R11214 T13456 T13457 compound methylation,status
R11215 T13457 T13453 pobj status,in
R11216 T13458 T13450 acl leading,subject
R11217 T13459 T13458 prep to,leading
R11218 T13460 T13461 compound expression,changes
R11219 T13461 T13459 pobj changes,to
R11220 T13462 T13461 punct ",",changes
R11221 T13329 T13327 pobj treatment,of
R11222 T13463 T13465 nsubj which,contribute
R11223 T13464 T13465 aux might,contribute
R11224 T13465 T13461 relcl contribute,changes
R11225 T13330 T13329 prep with,treatment
R11226 T13466 T13465 prep to,contribute
R11227 T13467 T13468 det the,initiation
R11228 T13468 T13466 pobj initiation,to
R11229 T13331 T13332 amod demethylating,agents
R11230 T13469 T13468 cc and/or,initiation
R11231 T13470 T13468 conj progression,initiation
R11232 T13332 T13330 pobj agents,with
R11233 T13333 T13332 punct (,agents
R11234 T13334 T13332 appos 42,agents
R11235 T13471 T13468 prep of,initiation
R11236 T13472 T13471 pobj cancer,of
R11237 T13473 T13448 punct .,be
R11238 T13335 T13332 appos 45,agents
R11239 T13336 T13332 punct ),agents
R11240 T13337 T13322 punct .,demonstrated
R11241 T13474 T13482 advmod Still,remains
R11242 T13475 T13482 punct ",",remains
R11243 T13338 T13339 det The,expression
R11244 T13476 T13479 det the,diversity
R11245 T13477 T13479 amod obvious,diversity
R11246 T13339 T13355 nsubjpass expression,impaired
R11247 T13478 T13479 amod functional,diversity
R11248 T13479 T13482 nsubj diversity,remains
R11249 T13480 T13479 prep of,diversity
R11250 T13340 T13339 prep of,expression
R11251 T13481 T13480 pobj IRF-4,of
R11252 T13482 T13482 ROOT remains,remains
R11253 T13341 T13355 det another,impaired
R11254 T13483 T13482 acomp remarkable,remains
R11255 T13484 T13482 cc and,remains
R11256 T13485 T13489 aux can,explained
R11257 T13342 T13355 npadvmod IRF,impaired
R11258 T13486 T13489 neg not,explained
R11259 T13487 T13489 auxpass be,explained
R11260 T13488 T13489 advmod fully,explained
R11261 T13343 T13355 punct ",",impaired
R11262 T13489 T13482 conj explained,remains
R11263 T13344 T13346 compound IFN,sequence
R11264 T13345 T13346 compound consensus,sequence
R11265 T13346 T13355 nsubjpass sequence,impaired
R11266 T13490 T13489 agent by,explained
R11267 T13347 T13348 amod binding,protein
R11268 T13491 T13495 det the,status
R11269 T13492 T13495 amod IRF-4,status
R11270 T13493 T13495 compound promoter,status
R11271 T13494 T13495 compound methylation,status
R11272 T13495 T13490 pobj status,by
R11273 T13496 T13482 punct .,remains
R11274 T13348 T13346 dobj protein,sequence
R11275 T13497 T13503 prep For,known
R11276 T13498 T13497 pobj example,For
R11277 T13499 T13503 punct ",",known
R11278 T13349 T13350 punct (,ICSBP/IRF
R11279 T13500 T13503 nsubjpass IRF-4,known
R11280 T13501 T13503 auxpass is,known
R11281 T13350 T13348 appos ICSBP/IRF,protein
R11282 T13502 T13503 advmod primarily,known
R11283 T13503 T13503 ROOT known,known
R11284 T13504 T13503 prep for,known
R11285 T13351 T13350 nummod -8,ICSBP/IRF
R11286 T13505 T13507 poss its,features
R11287 T13506 T13507 amod oncogenic,features
R11288 T13507 T13504 pobj features,for
R11289 T13352 T13350 punct ),ICSBP/IRF
R11290 T13508 T13503 punct .,known
R11291 T13509 T13521 prep In,reported
R11292 T13510 T13511 amod multiple,myeloma
R11293 T13353 T13355 punct ",",impaired
R11294 T13511 T13509 pobj myeloma,In
R11295 T13512 T13513 punct (,MM
R11296 T13354 T13355 auxpass is,impaired
R11297 T13513 T13511 appos MM,myeloma
R11298 T13514 T13513 punct ),MM
R11299 T13515 T13516 det a,translocation
R11300 T13516 T13521 nsubjpass translocation,reported
R11301 T13517 T13516 prep on,translocation
R11302 T13355 T13355 ROOT impaired,impaired
R11303 T13518 T13517 pobj chromosome,on
R11304 T13519 T13518 nummod 14q,chromosome
R11305 T13520 T13521 auxpass was,reported
R11306 T13521 T13521 ROOT reported,reported
R11307 T13356 T13355 prep in,impaired
R11308 T13522 T13523 aux to,lead
R11309 T13523 T13521 xcomp lead,reported
R11310 T13524 T13523 prep to,lead
R11311 T13357 T13358 amod myeloid,leukemias
R11312 T13525 T13527 det a,gene
R11313 T13526 T13527 compound fusion,gene
R11314 T13527 T13524 pobj gene,to
R11315 T13358 T13356 pobj leukemias,in
R11316 T13528 T13527 prep of,gene
R11317 T13529 T13530 compound immunoglobulin,heavy-chain
R11318 T13530 T13528 pobj heavy-chain,of
R11319 T13531 T13532 punct (,IgH
R11320 T13532 T13530 appos IgH,heavy-chain
R11321 T13533 T13532 punct ),IgH
R11322 T13359 T13360 advmod especially,CML
R11323 T13534 T13530 cc and,heavy-chain
R11324 T13535 T13530 conj IRF-4,heavy-chain
R11325 T13536 T13527 acl resulting,gene
R11326 T13360 T13358 appos CML,leukemias
R11327 T13537 T13536 prep in,resulting
R11328 T13538 T13540 det a,overexpression
R11329 T13361 T13360 punct (,CML
R11330 T13539 T13540 amod subsequent,overexpression
R11331 T13540 T13537 pobj overexpression,in
R11332 T13541 T13540 prep of,overexpression
R11333 T13362 T13360 appos "27,46,47",CML
R11334 T13542 T13541 pobj IRF-4,of
R11335 T13543 T13544 punct (,"48,49"
R11336 T13544 T13542 parataxis "48,49",IRF-4
R11337 T13363 T13360 punct ),CML
R11338 T13545 T13540 punct ),overexpression
R11339 T13546 T13521 punct .,reported
R11340 T13364 T13355 punct .,impaired
R11341 T13547 T13554 prep In,found
R11342 T13548 T13547 pobj addition,In
R11343 T13549 T13554 punct ",",found
R11344 T13365 T13379 cc But,reverted
R11345 T13550 T13552 amod abundant,expression
R11346 T13366 T13379 prep in,reverted
R11347 T13367 T13366 pobj contrast,in
R11348 T13551 T13552 compound IRF-4,expression
R11349 T13368 T13367 prep to,contrast
R11350 T13369 T13368 pobj IRF-4,to
R11351 T13552 T13554 nsubjpass expression,found
R11352 T13370 T13369 punct ",",IRF-4
R11353 T13553 T13554 auxpass was,found
R11354 T13371 T13372 det the,loss
R11355 T13554 T13554 ROOT found,found
R11356 T13555 T13556 aux to,be
R11357 T13556 T13554 xcomp be,found
R11358 T13557 T13558 det a,marker
R11359 T13372 T13369 appos loss,IRF-4
R11360 T13558 T13556 attr marker,be
R11361 T13559 T13558 prep for,marker
R11362 T13373 T13372 prep of,loss
R11363 T13560 T13561 amod various,subsets
R11364 T13561 T13559 pobj subsets,for
R11365 T13374 T13375 det this,IRF
R11366 T13562 T13561 prep of,subsets
R11367 T13563 T13562 pobj lymphomas,of
R11368 T13564 T13563 punct ",",lymphomas
R11369 T13565 T13566 amod such,as
R11370 T13566 T13563 prep as,lymphomas
R11371 T13567 T13566 pobj diffuse,as
R11372 T13375 T13373 pobj IRF,of
R11373 T13568 T13570 amod large,lymphomas
R11374 T13569 T13570 compound B-cell,lymphomas
R11375 T13570 T13567 dobj lymphomas,diffuse
R11376 T13376 T13379 aux could,reverted
R11377 T13571 T13570 punct ",",lymphomas
R11378 T13572 T13574 amod primary,lymphoma
R11379 T13573 T13574 compound effusion,lymphoma
R11380 T13377 T13379 neg not,reverted
R11381 T13574 T13570 conj lymphoma,lymphomas
R11382 T13575 T13574 punct ",",lymphoma
R11383 T13576 T13574 cc and,lymphoma
R11384 T13577 T13578 amod marginal,zone
R11385 T13378 T13379 auxpass be,reverted
R11386 T13578 T13574 conj zone,lymphoma
R11387 T13579 T13574 conj lymphoma,lymphoma
R11388 T13580 T13579 punct ",",lymphoma
R11389 T13379 T13379 ROOT reverted,reverted
R11390 T13581 T13579 cc and,lymphoma
R11391 T13582 T13584 compound adult,leukemia
R11392 T13380 T13379 prep in,reverted
R11393 T13583 T13584 compound T-cell,leukemia
R11394 T13584 T13579 conj leukemia,lymphoma
R11395 T13585 T13586 punct (,"11,31,50"
R11396 T13586 T13584 appos "11,31,50",leukemia
R11397 T13381 T13383 amod ICSBP-negative,lines
R11398 T13382 T13383 compound cell,lines
R11399 T13383 T13380 pobj lines,in
R11400 T13587 T13584 appos 52,leukemia
R11401 T13384 T13383 punct (,lines
R11402 T13588 T13584 punct ),leukemia
R11403 T13589 T13554 punct .,found
R11404 T13590 T13591 nsubj This,draws
R11405 T13385 T13383 appos EM-2,lines
R11406 T13591 T13591 ROOT draws,draws
R11407 T13592 T13595 det a,picture
R11408 T13386 T13385 punct ",",EM-2
R11409 T13593 T13594 advmod more,complex
R11410 T13594 T13595 amod complex,picture
R11411 T13387 T13385 conj CML-T1,EM-2
R11412 T13595 T13591 dobj picture,draws
R11413 T13596 T13595 prep of,picture
R11414 T13597 T13598 det the,role
R11415 T13388 T13387 punct ",",CML-T1
R11416 T13598 T13596 pobj role,of
R11417 T13599 T13598 prep of,role
R11418 T13600 T13599 pobj IRF-4,of
R11419 T13601 T13591 punct .,draws
R11420 T13602 T13606 nsubj Down-regulation,promote
R11421 T13603 T13602 prep of,Down-regulation
R11422 T13604 T13603 pobj IRF-4,of
R11423 T13389 T13387 conj K-562,CML-T1
R11424 T13605 T13606 aux may,promote
R11425 T13606 T13606 ROOT promote,promote
R11426 T13607 T13606 dobj leukemogenesis,promote
R11427 T13390 T13389 cc and,K-562
R11428 T13608 T13607 prep in,leukemogenesis
R11429 T13609 T13611 amod myeloid,context
R11430 T13610 T13611 compound cell,context
R11431 T13391 T13389 conj LAMA-84,K-562
R11432 T13611 T13608 pobj context,in
R11433 T13612 T13613 punct (,3
R11434 T13613 T13607 parataxis 3,leukemogenesis
R11435 T13392 T13383 punct ),lines
R11436 T13614 T13613 punct ),3
R11437 T13615 T13613 punct ",",3
R11438 T13616 T13619 nsubjpass which,confirmed
R11439 T13617 T13619 auxpass was,confirmed
R11440 T13653 T13652 advmod together,Taken
R11441 T13618 T13619 advmod recently,confirmed
R11442 T13619 T13613 relcl confirmed,3
R11443 T13620 T13619 prep in,confirmed
R11444 T13621 T13620 pobj IRF-4,in
R11445 T13622 T13631 nmod −,mice
R11446 T13654 T13657 punct ",",suggest
R11447 T13623 T13631 nmod /,mice
R11448 T13624 T13631 nmod −,mice
R11449 T13625 T13631 nmod ICSBP,mice
R11450 T13655 T13656 poss our,data
R11451 T13626 T13631 nmod −,mice
R11452 T13656 T13657 nsubj data,suggest
R11453 T13657 T13657 ROOT suggest,suggest
R11454 T13627 T13631 nmod /,mice
R11455 T13658 T13662 mark that,regulates
R11456 T13628 T13631 nmod −,mice
R11457 T13629 T13631 amod double,mice
R11458 T13659 T13661 amod IRF-4,methylation
R11459 T13660 T13661 compound promoter,methylation
R11460 T13630 T13631 amod knock-out,mice
R11461 T13661 T13662 nsubj methylation,regulates
R11462 T13631 T13619 dobj mice,confirmed
R11463 T13632 T13631 punct (,mice
R11464 T13633 T13631 appos 53,mice
R11465 T13662 T13657 ccomp regulates,suggest
R11466 T13634 T13631 punct ),mice
R11467 T13635 T13619 punct ",",confirmed
R11468 T13636 T13640 mark while,induce
R11469 T13637 T13638 compound IRF-4,up-regulation
R11470 T13638 T13640 nsubj up-regulation,induce
R11471 T13663 T13664 amod IRF-4,expression
R11472 T13639 T13640 aux may,induce
R11473 T13640 T13619 advcl induce,confirmed
R11474 T13641 T13643 det a,advantage
R11475 T13664 T13662 dobj expression,regulates
R11476 T13642 T13643 compound growth,advantage
R11477 T13643 T13640 dobj advantage,induce
R11478 T13644 T13640 prep in,induce
R11479 T13665 T13662 punct ",",regulates
R11480 T13645 T13644 pobj lymphomas,in
R11481 T13646 T13645 cc or,lymphomas
R11482 T13666 T13662 cc and,regulates
R11483 T13647 T13645 conj MM,lymphomas
R11484 T13648 T13647 punct (,MM
R11485 T13649 T13647 appos 48,MM
R11486 T13650 T13647 punct ),MM
R11487 T13667 T13678 mark that,be
R11488 T13651 T13606 punct .,promote
R11489 T13652 T13657 advcl Taken,suggest
R11490 T13668 T13669 amod aberrant,expression
R11491 T13684 T13681 pobj hypermethylation,of
R11492 T13669 T13678 nsubj expression,be
R11493 T13685 T13657 punct .,suggest
R11494 T13670 T13669 prep of,expression
R11495 T13671 T13670 pobj IRF-4,of
R11496 T13672 T13669 prep in,expression
R11497 T13673 T13674 amod certain,types
R11498 T13674 T13672 pobj types,in
R11499 T13675 T13674 prep of,types
R11500 T13676 T13675 pobj leukemia,of
R11501 T13677 T13678 aux may,be
R11502 T13678 T13662 conj be,regulates
R11503 T13679 T13680 det a,consequence
R11504 T13680 T13678 attr consequence,be
R11505 T13681 T13680 prep of,consequence
R11506 T13682 T13684 compound IRF-4,hypermethylation
R11507 T13683 T13684 compound promoter,hypermethylation
R1348 T1725 T1727 nmod Chronic,leukemia
R1349 T1726 T1727 amod myeloid,leukemia
R318 T429 T430 amod leukemic,cells
R319 T430 T428 pobj cells,in
R320 T431 T420 amod due,Down-regulation
R321 T432 T431 pcomp to,due
R322 T433 T432 pobj hypermethylation,to
R323 T434 T433 prep of,hypermethylation
R324 T435 T436 compound CpG,motifs
R325 T436 T434 pobj motifs,of
R400 T511 T510 cc or,reversible
R401 T512 T510 conj permanent,reversible
R402 T513 T508 pobj silencing,of
R403 T514 T513 prep of,silencing
R404 T515 T516 compound gene,expression
R405 T516 T514 pobj expression,of
R406 T517 T513 punct ",",silencing
R407 T518 T506 advmod respectively,are
R408 T519 T506 punct .,are
R409 T520 T523 advmod Therefore,investigated
R1350 T1727 T1731 nsubj leukemia,is
R309 T420 T420 ROOT Down-regulation,Down-regulation
R310 T421 T420 prep of,Down-regulation
R311 T422 T424 nmod interferon,factor
R312 T423 T424 amod regulatory,factor
R313 T424 T421 pobj factor,of
R314 T425 T427 nummod 4,expression
R315 T426 T427 compound gene,expression
R316 T427 T420 conj expression,Down-regulation
R317 T428 T427 prep in,expression
R382 T493 T492 pobj CML,of
R383 T494 T463 punct .,is
R384 T495 T496 compound Promoter,methylation
R385 T496 T506 nsubj methylation,are
R386 T497 T496 prep of,methylation
R387 T498 T500 compound CpG,sites
R388 T499 T500 compound target,sites
R389 T500 T497 pobj sites,of
R390 T501 T500 cc or,sites
R391 T502 T503 amod direct,deletions/insertions
R392 T503 T500 conj deletions/insertions,sites
R393 T504 T503 prep of,deletions/insertions
R394 T505 T504 pobj genes,of
R395 T506 T506 ROOT are,are
R396 T507 T506 attr mechanisms,are
R397 T508 T507 prep of,mechanisms
R398 T509 T513 det a,silencing
R399 T510 T513 amod reversible,silencing
R6990 T8350 T8351 amod BV-173,cells
R6991 T8351 T8348 conj cells,SD-1
R6992 T8352 T8353 auxpass is,associated
R6993 T8353 T8343 ccomp associated,implied
R6994 T8354 T8353 prep with,associated
R6995 T8355 T8356 amod less,promoter
R6996 T8356 T8357 compound promoter,methylation
R6997 T8357 T8354 pobj methylation,with
R6998 T8358 T8357 punct (,methylation
R6999 T8359 T8357 prep in,methylation
R7000 T8360 T8359 pobj BV-173,in
R7001 T8361 T8362 advmod especially,at
R7002 T8362 T8357 prep at,methylation
R7003 T8363 T8364 compound HpaII,sites
R7004 T8364 T8362 pobj sites,at
R7005 T8365 T8353 punct ),associated
R7006 T8366 T8367 mark as,compared
R7007 T8367 T8343 advcl compared,implied
R7008 T8368 T8367 prep with,compared
R8673 T10466 T10467 nsubj we,studied
R8674 T10467 T10445 advcl studied,associated
R8675 T10468 T10470 poss their,expression
R8676 T10469 T10470 compound mRNA,expression
R8677 T10470 T10467 dobj expression,studied
R8678 T10471 T10472 aux to,investigate
R8679 T10472 T10467 advcl investigate,studied
R8680 T10473 T10475 det a,mechanism
R8681 T10474 T10475 amod possible,mechanism
R8682 T10475 T10472 dobj mechanism,investigate
R8683 T10476 T10475 prep for,mechanism
R8684 T10477 T10480 det the,differences
R8685 T10478 T10480 amod observed,differences
R8686 T10479 T10480 compound methylation,differences
R8687 T10480 T10476 pobj differences,for
R8688 T10481 T10480 prep in,differences
R8689 T10482 T10484 det the,promoter
R8690 T10483 T10484 compound IRF-4,promoter
R8691 T10484 T10481 pobj promoter,in
R8692 T10485 T10445 punct .,associated
R8693 T10486 T10493 prep To,detect
R8694 T10487 T10488 det this,end
R8695 T10488 T10486 pobj end,To
R8696 T10489 T10493 punct ",",detect
R8697 T10490 T10493 nsubj we,detect
R8711 T10504 T10502 conj DNMT3B,DNMT3A
R8712 T10505 T10504 punct ),DNMT3B
R8713 T10506 T10504 cc or,DNMT3B
R8714 T10507 T10504 conj MBP,DNMT3B
R8715 T10508 T10509 punct (,MBD1
R8716 T10509 T10504 conj MBD1,DNMT3B
R8717 T10510 T10509 punct ",",MBD1
R8718 T10511 T10509 conj MBD2,MBD1
R8719 T10512 T10511 punct ",",MBD2
R8720 T10513 T10511 conj MBD4,MBD2
R8721 T10514 T10513 cc and,MBD4
R8722 T10515 T10513 conj MeCP,MBD4
R8723 T10516 T10509 punct ),MBD1
R8724 T10517 T10518 compound mRNA,expression

UBERON-AE

Id Subject Object Predicate Lexical cue
T2857 5666-5671 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T5672 12839-12843 http://purl.obolibrary.org/obo/UBERON_0007379 denotes EG&G
T6183 13614-13619 http://purl.obolibrary.org/obo/UBERON_2000006 denotes B-ALL
T11135 24728-24735 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
T11136 25250-25255 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T11137 25257-25261 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T11138 25571-25582 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

GO-BP

Id Subject Object Predicate Lexical cue
T114 5-15 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T115 731-741 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T116 1478-1488 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T117 50-65 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T118 603-618 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T119 357-370 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T120 999-1012 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T121 444-456 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T122 474-485 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T123 684-695 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T124 937-948 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T125 1101-1112 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T126 1436-1447 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T127 1713-1724 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T128 590-607 http://purl.obolibrary.org/obo/GO_0016458 denotes silencing of gene
T1076 2046-2051 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T1077 2688-2703 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T1078 4759-4774 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T1079 4847-4860 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1080 2816-2826 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1081 3759-3769 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1082 2890-2899 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T1083 4030-4039 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T1084 2890-2899 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T1085 4030-4039 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T1086 3043-3066 http://purl.obolibrary.org/obo/GO_0050798 denotes activated T-lymphocytes
T1087 3043-3066 http://purl.obolibrary.org/obo/GO_0051132 denotes activated T-lymphocytes
T1088 3043-3066 http://purl.obolibrary.org/obo/GO_0042110 denotes activated T-lymphocytes
T1089 3043-3066 http://purl.obolibrary.org/obo/GO_0050863 denotes activated T-lymphocytes
T1090 3218-3234 http://purl.obolibrary.org/obo/GO_0002452 denotes B-cell receptors
T1091 3610-3621 http://purl.obolibrary.org/obo/GO_0032259 denotes Methylation
T1092 3977-3988 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T1093 4248-4259 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T1094 4357-4368 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T1095 4569-4580 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T1096 3803-3817 http://purl.obolibrary.org/obo/GO_0016458 denotes gene silencing
T1097 3875-3906 http://purl.obolibrary.org/obo/GO_0044027 denotes hypermethylation of CpG islands
T1098 4006-4016 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T1099 4006-4021 http://purl.obolibrary.org/obo/GO_0044786 denotes cell cycle, DNA
T1100 4018-4028 http://purl.obolibrary.org/obo/GO_0006281 denotes DNA repair
T1101 4044-4060 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressor
T1102 4167-4171 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T1103 4943-4958 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T3421 6851-6866 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T3422 7012-7021 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T3423 8673-8675 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T4365 8718-8729 http://purl.obolibrary.org/obo/GO_0032259 denotes Methylation
T4366 8897-8908 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T4367 8943-8954 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T4368 9085-9096 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T4369 9978-9989 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T4370 9930-9951 http://purl.obolibrary.org/obo/GO_0006277 denotes DNA and amplification
T4942 10773-10780 http://purl.obolibrary.org/obo/GO_0031214 denotes mineral
T5693 12066-12077 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T5694 12316-12327 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T5695 12235-12244 http://purl.obolibrary.org/obo/GO_0008168 denotes Methylase
T5696 12779-12798 http://purl.obolibrary.org/obo/GO_0045289 denotes luciferase activity
T5697 12779-12798 http://purl.obolibrary.org/obo/GO_0047077 denotes luciferase activity
T5698 12779-12798 http://purl.obolibrary.org/obo/GO_0047712 denotes luciferase activity
T5699 12779-12798 http://purl.obolibrary.org/obo/GO_0050248 denotes luciferase activity
T5700 12779-12798 http://purl.obolibrary.org/obo/GO_0050397 denotes luciferase activity
T7016 14442-14453 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T7017 14745-14756 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T7018 14799-14810 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T7019 15812-15823 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T7020 14484-14494 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T7021 14945-14958 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T7022 15054-15067 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T7023 15915-15930 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T7024 15435-15445 http://purl.obolibrary.org/obo/GO_0006412 denotes translated
T7840 15972-15983 http://purl.obolibrary.org/obo/GO_0032259 denotes Methylation
T7841 16105-16116 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T7842 16413-16424 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T7843 16563-16574 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T7844 16910-16921 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T7845 17063-17074 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T7846 17435-17446 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T7847 16152-16167 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T7848 16725-16734 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T7849 17044-17053 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T7850 17201-17210 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T7851 17363-17376 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T8571 17643-17654 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T8572 18008-18019 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T8573 18119-18130 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T8574 18447-18458 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T8575 19392-19403 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T8576 19684-19695 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T8577 19703-19713 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T9697 19763-19774 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T9698 20026-20037 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T9699 20050-20061 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T9700 20122-20133 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T9701 20185-20196 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T9702 20340-20351 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T9703 20411-20422 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T9704 20535-20546 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T9705 20735-20746 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T10249 20900-20911 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T10250 20982-20993 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T10251 21092-21103 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T10252 21540-21551 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T10253 20967-20977 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10254 21642-21660 http://purl.obolibrary.org/obo/GO_0009299 denotes mRNA transcription
T10255 21647-21660 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T11315 21718-21733 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T11316 21737-21753 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressor
T11317 26815-26831 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressor
T11318 21862-21873 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11319 23909-23920 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11320 24291-24302 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11321 24709-24720 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11322 24856-24867 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11323 24932-24943 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11324 25035-25046 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11325 25154-25165 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11326 25871-25882 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11327 26918-26929 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11328 27159-27170 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11329 28030-28041 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11330 21893-21928 http://purl.obolibrary.org/obo/GO_0051091 denotes activation of transcription factors
T11331 21893-21928 http://purl.obolibrary.org/obo/GO_0032793 denotes activation of transcription factors
T11332 21893-21928 http://purl.obolibrary.org/obo/GO_1901485 denotes activation of transcription factors
T11333 21907-21920 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T11334 22656-22669 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T11335 23423-23438 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T11336 23020-23033 http://purl.obolibrary.org/obo/GO_0070988 denotes demethylation
T11337 23199-23209 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11338 23695-23705 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11339 24469-24479 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11340 27742-27752 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11341 27911-27921 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11342 23510-23525 http://purl.obolibrary.org/obo/GO_0016458 denotes silencing genes
T11343 25571-25588 http://purl.obolibrary.org/obo/GO_0071839 denotes bone marrow cells
T11344 25571-25588 http://purl.obolibrary.org/obo/GO_0071838 denotes bone marrow cells
T11345 27935-27941 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

GO-MF

Id Subject Object Predicate Lexical cue
T695 1622-1640 http://purl.obolibrary.org/obo/GO_0008327 denotes methyl-CpG-binding
T696 1633-1640 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T697 1633-1649 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T2349 2761-2772 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA-binding
T2350 2761-2779 http://purl.obolibrary.org/obo/GO_0050692 denotes DNA-binding domain
T2351 2765-2772 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T2352 4697-4704 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T2353 4748-4755 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T2354 4167-4171 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T2355 4697-4713 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T2356 4748-4782 http://purl.obolibrary.org/obo/GO_0008134 denotes binding of transcriptional factors
T2357 4748-4782 http://purl.obolibrary.org/obo/GO_0033613 denotes binding of transcriptional factors
T2358 4748-4782 http://purl.obolibrary.org/obo/GO_0043425 denotes binding of transcriptional factors
T2359 4748-4782 http://purl.obolibrary.org/obo/GO_0070491 denotes binding of transcriptional factors
T4176 8320-8328 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T4177 8390-8398 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T4178 8589-8599 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T4179 8673-8675 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T6052 12235-12244 http://purl.obolibrary.org/obo/GO_0008168 denotes Methylase
T6053 12779-12798 http://purl.obolibrary.org/obo/GO_0045289 denotes luciferase activity
T6054 12779-12798 http://purl.obolibrary.org/obo/GO_0047077 denotes luciferase activity
T6055 12779-12798 http://purl.obolibrary.org/obo/GO_0047712 denotes luciferase activity
T6056 12779-12798 http://purl.obolibrary.org/obo/GO_0050248 denotes luciferase activity
T6057 12779-12798 http://purl.obolibrary.org/obo/GO_0050397 denotes luciferase activity
T10589 20830-20848 http://purl.obolibrary.org/obo/GO_0008327 denotes methyl-CpG-binding
T10590 20841-20848 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10591 20841-20857 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T13723 21893-21928 http://purl.obolibrary.org/obo/GO_0033613 denotes activation of transcription factors
T13724 22656-22684 http://purl.obolibrary.org/obo/GO_0033613 denotes transcription factor binding
T13725 22656-22684 http://purl.obolibrary.org/obo/GO_0008134 denotes transcription factor binding
T13726 22656-22684 http://purl.obolibrary.org/obo/GO_0043425 denotes transcription factor binding
T13727 22656-22684 http://purl.obolibrary.org/obo/GO_0070491 denotes transcription factor binding
T13728 22677-22684 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13729 22754-22761 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13730 24611-24618 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13731 24769-24776 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13732 26365-26372 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13733 26356-26380 http://purl.obolibrary.org/obo/GO_0005048 denotes sequence binding protein
T13734 26365-26380 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein
T13735 27345-27359 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin

ICD10

Id Subject Object Predicate Lexical cue
T6719 13635-13651 http://purl.bioontology.org/ontology/ICD10/C90.0 denotes multiple myeloma
T13736 26191-26216 http://purl.bioontology.org/ontology/ICD10/D46 denotes myelodysplastic syndromes
T13737 26191-26216 http://purl.bioontology.org/ontology/ICD10/D46.9 denotes myelodysplastic syndromes
T13738 27248-27264 http://purl.bioontology.org/ontology/ICD10/C90.0 denotes multiple myeloma

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T838 19-54 Protein denotes interferon regulatory factor 4 gene
T839 55-65 Gene_expression denotes expression
T840 0-15 Negative_regulation denotes Down-regulation
T841 169-172 Protein denotes bcr
T842 173-176 Protein denotes abl
T843 378-408 Protein denotes interferon regulatory factor 4
T844 410-415 Protein denotes IRF-4
T845 316-328 Regulation denotes deregulation
T846 316-328 Regulation denotes deregulation
T847 669-683 Protein denotes IRF-4 promoter
T848 745-750 Protein denotes IRF-4
T849 751-761 Gene_expression denotes expression
T850 731-741 Regulation denotes regulation
T851 877-882 Protein denotes IRF-4
T852 922-936 Protein denotes IRF-4 promoter
T853 993-998 Protein denotes IRF-4
T854 883-893 Gene_expression denotes expression
T855 999-1012 Transcription denotes transcription
T856 869-876 Regulation denotes altered
T857 983-992 Regulation denotes influence
T858 1205-1215 Protein denotes IRF-4 mRNA
T859 1193-1201 Positive_regulation denotes increase
T860 1376-1381 Protein denotes IRF-4
T861 1382-1390 Gene_expression denotes positive
T862 1467-1472 Protein denotes IRF-4
T863 1473-1488 Negative_regulation denotes down-regulation
T864 1698-1712 Protein denotes IRF-4 promoter
T865 1767-1772 Protein denotes IRF-4
T866 1773-1783 Gene_expression denotes expression
T867 1752-1766 Negative_regulation denotes down-regulated
T2565 2199-2202 Protein denotes bcr
T2566 2203-2206 Protein denotes abl
T2567 2183-2193 Gene_expression denotes expression
T2568 2183-2193 Gene_expression denotes expression
T2569 2172-2179 Positive_regulation denotes leading
T2570 2172-2179 Positive_regulation denotes leading
T2571 2278-2290 Protein denotes interferon α
T2572 2292-2297 Protein denotes IFN-α
T2573 2473-2503 Protein denotes interferon regulatory factor 4
T2574 2505-2510 Protein denotes IRF-4
T2575 2554-2559 Protein denotes IFN-α
T2576 2455-2465 Gene_expression denotes expression
T2577 2455-2465 Gene_expression denotes expression
T2578 2446-2454 Negative_regulation denotes impaired
T2579 2446-2454 Negative_regulation denotes impaired
T2580 2605-2610 Protein denotes IRF-4
T2581 2592-2601 Negative_regulation denotes silencing
T2582 2635-2664 Protein denotes Interferon regulatory factors
T2583 2666-2670 Protein denotes IRFs
T2584 2853-2857 Protein denotes IFNs
T2585 2859-2871 Protein denotes interleukins
T2586 2873-2887 Protein denotes MHC class I/II
T2587 2816-2826 Regulation denotes regulation
T2588 2816-2826 Regulation denotes regulation
T2589 2816-2826 Regulation denotes regulation
T2590 2938-2943 Protein denotes IRF-4
T2591 2945-2950 Protein denotes ICSAT
T2592 2951-2954 Protein denotes Pip
T2593 2955-2959 Protein denotes MUM1
T2594 2960-2965 Protein denotes LSIRF
T2595 3071-3076 Protein denotes IRF-4
T2596 3002-3012 Gene_expression denotes expression
T2597 3002-3012 Gene_expression denotes expression
T2598 3002-3012 Gene_expression denotes expression
T2599 3002-3012 Gene_expression denotes expression
T2600 3002-3012 Gene_expression denotes expression
T2601 3077-3085 Gene_expression denotes positive
T2602 3115-3119 Protein denotes IRFs
T2603 3135-3140 Protein denotes IRF-4
T2604 3162-3166 Protein denotes IFNs
T2605 3121-3131 Gene_expression denotes expression
T2606 3151-3158 Positive_regulation denotes induced
T2607 3367-3372 Protein denotes IRF-4
T2608 3480-3485 Protein denotes IRF-4
T2609 3355-3363 Negative_regulation denotes deletion
T2610 3466-3476 Gene_expression denotes expression
T2611 3571-3576 Protein denotes IRF-4
T2612 4167-4171 Protein denotes MGMT
T2613 4173-4177 Protein denotes DAPK
T2614 4179-4185 Protein denotes p14ARF
T2615 4187-4195 Protein denotes p15INK4b
T2616 4197-4205 Protein denotes p16INK4a
T2617 4207-4212 Protein denotes BRCA1
T2618 4214-4219 Protein denotes CDH13
T2619 4224-4230 Protein denotes APAF-1
T2620 4299-4304 Protein denotes c-abl
T2621 4310-4318 Protein denotes bcr gene
T2622 4376-4390 Protein denotes c-abl promoter
T2623 4281-4291 Gene_expression denotes expression
T2624 4281-4291 Gene_expression denotes expression
T2625 4272-4280 Regulation denotes regulate
T2626 4272-4280 Regulation denotes regulate
T2627 4493-4515 Protein denotes DNA methyltransferases
T2628 4517-4522 Protein denotes DNMTs
T2629 4475-4489 Gene_expression denotes overexpression
T2630 4475-4489 Gene_expression denotes overexpression
T2631 4475-4489 Positive_regulation denotes overexpression
T2632 4475-4489 Positive_regulation denotes overexpression
T2633 4686-4713 Protein denotes Methyl-CpG-binding proteins
T2634 4715-4719 Protein denotes MBPs
T2635 4790-4798 Entity denotes promoter
T2636 4748-4755 Binding denotes binding
T2637 4748-4755 Binding denotes binding
T2638 4748-4755 Binding denotes binding
T2639 4736-4743 Negative_regulation denotes inhibit
T2640 4736-4743 Negative_regulation denotes inhibit
T2641 4736-4743 Negative_regulation denotes inhibit
T2642 4736-4743 Negative_regulation denotes inhibit
T2643 4736-4743 Negative_regulation denotes inhibit
T2644 4736-4743 Negative_regulation denotes inhibit
T2645 4937-4947 Protein denotes IRF-4 gene
T2646 4948-4958 Gene_expression denotes expression
T2647 4959-4968 Negative_regulation denotes silencing
T2648 5004-5025 Protein denotes IRF-4 promoter region
T2649 5097-5106 Gene_expression denotes -negative
T4923 8973-8978 Protein denotes HpaII
T4924 8983-9009 Protein denotes HaeII-isochizomer Bsp143II
T4925 9014-9022 Protein denotes Bsh1236I
T4926 9024-9027 Protein denotes MBI
T4927 9182-9187 Protein denotes EcoRI
T4928 9440-9454 Protein denotes IRF-4 promoter
T6102 12107-12145 Protein denotes IRF-4 promoter-reporter gene construct
T6103 12231-12244 Protein denotes CpG Methylase
T6104 12246-12247 Protein denotes M
T6105 12248-12253 Protein denotes Sss I
T6106 12414-12424 Protein denotes luciferase
T6107 12584-12607 Protein denotes renilla luciferase gene
T6108 12569-12579 Gene_expression denotes expressing
T6109 12613-12636 Gene_expression denotes transientlyco-expressed
T6110 12779-12789 Protein denotes luciferase
T6111 12877-12891 Protein denotes IRF-4 promoter
T6112 12892-12902 Positive_regulation denotes activation
T6847 13069-13074 Protein denotes IRF-4
T6848 13075-13085 Gene_expression denotes expression
T6849 13058-13065 Negative_regulation denotes Absence
T6850 13111-13114 Positive_regulation denotes due
T6851 13181-13186 Protein denotes IRF-4
T6852 13187-13197 Gene_expression denotes expression
T6853 13173-13177 Negative_regulation denotes lack
T6854 13292-13297 Protein denotes IRF-4
T6855 13391-13394 Protein denotes bcr
T6856 13395-13398 Protein denotes abl
T6857 13430-13433 Protein denotes bcr
T6858 13434-13437 Protein denotes abl
T6859 13492-13496 Protein denotes EM-2
T6860 13501-13508 Protein denotes LAMA-84
T6861 13510-13513 Protein denotes bcr
T6862 13514-13517 Protein denotes abl
T6863 13563-13566 Protein denotes bcr
T6864 13567-13570 Protein denotes abl
T6865 13666-13669 Protein denotes bcr
T6866 13670-13673 Protein denotes abl
T6867 13298-13308 Gene_expression denotes expression
T6868 13399-13407 Gene_expression denotes positive
T6869 13399-13407 Gene_expression denotes positive
T6870 13438-13445 Gene_expression denotes positve
T6871 13438-13445 Gene_expression denotes positve
T6872 13518-13525 Gene_expression denotes positve
T6873 13518-13525 Gene_expression denotes positve
T6874 13571-13579 Gene_expression denotes positive
T6875 13571-13579 Gene_expression denotes positive
T6876 13674-13682 Gene_expression denotes positive
T6877 13674-13682 Gene_expression denotes positive
T6878 13740-13754 Protein denotes IRF-4 promoter
T6879 13793-13798 Protein denotes IRF-4
T6880 13799-13809 Gene_expression denotes expression
T6881 13782-13789 Negative_regulation denotes absence
T6882 13964-13969 Protein denotes IRF-4
T6883 13970-13978 Gene_expression denotes positive
T6884 14307-14312 Protein denotes IRF-4
T6885 14313-14323 Gene_expression denotes expression
T6886 14300-14306 Regulation denotes affect
T7746 15255-15272 Protein denotes IRF-4 transcripts
T7747 15333-15338 Protein denotes AzadC
T7748 15465-15478 Protein denotes IRF-4 protein
T7749 15479-15489 Gene_expression denotes expression
T7750 15452-15461 Positive_regulation denotes induction
T7751 15533-15538 Protein denotes IRF-4
T7752 15590-15595 Protein denotes AzadC
T7753 15613-15618 Protein denotes IRF-4
T7754 15539-15547 Gene_expression denotes positive
T7755 15619-15629 Gene_expression denotes expression
T7756 15603-15609 Regulation denotes effect
T7757 15726-15736 Protein denotes IRF-4 mRNA
T7758 15712-15721 Positive_regulation denotes increased
T7759 15836-15841 Protein denotes IRF-4
T7760 15945-15950 Protein denotes IRF-4
T7761 15954-15959 Protein denotes AzadC
T7762 15842-15852 Gene_expression denotes expression
T7763 15828-15835 Regulation denotes control
T8447 16035-16049 Protein denotes IRF-4 promoter
T8448 16146-16156 Protein denotes IRF-4 gene
T8449 16157-16167 Gene_expression denotes expression
T8450 16443-16448 Protein denotes HpaII
T8451 16450-16489 Protein denotes Bsh1236I and HaeII-isochizomer Bsp143II
T8452 16491-16496 Protein denotes EcoRI
T8453 16539-16553 Protein denotes IRF-4 promoter
T8454 16740-16745 Protein denotes HpaII
T8455 16750-16758 Protein denotes Bsp143II
T8456 16725-16734 Gene_expression denotes digestion
T8457 16725-16734 Gene_expression denotes digestion
T8458 17018-17023 Protein denotes IRF-4
T8459 17024-17032 Gene_expression denotes positive
T8460 17175-17180 Protein denotes HpaII
T8461 17357-17362 Protein denotes IRF-4
T8462 17472-17483 Protein denotes HpaII sites
T8463 17363-17376 Transcription denotes transcription
T9599 17545-17554 Protein denotes CpG sites
T9600 17562-17576 Protein denotes IRF-4 promoter
T9601 17672-17686 Protein denotes IRF-4 promoter
T9602 18367-18381 Protein denotes IRF-4 promoter
T9603 18466-18480 Protein denotes IRF-4 promoter
T9604 18486-18491 Protein denotes IRF-4
T9605 18492-18500 Gene_expression denotes positive
T9606 19269-19278 Protein denotes CpG sites
T9607 19426-19431 Protein denotes IRF-4
T9608 19432-19442 Gene_expression denotes expression
T9609 19461-19470 Protein denotes CpG sites
T9610 19484-19488 Protein denotes NFκB
T9611 19501-19504 Protein denotes SP1
T9612 19680-19683 Protein denotes CpG
T9613 19717-19722 Protein denotes IRF-4
T9614 19723-19733 Gene_expression denotes expression
T9615 19703-19713 Regulation denotes regulation
T9616 19665-19676 Regulation denotes involvement
T10121 19781-19814 Protein denotes IRF-4 promoter-reporter construct
T10122 19815-19824 Negative_regulation denotes decreases
T10123 19905-19919 Protein denotes IRF-4 promoter
T10124 20204-20218 Protein denotes IRF-4 promoter
T10125 20264-20269 Protein denotes IRF-4
T10126 20243-20251 Entity denotes promoter
T10127 20270-20278 Gene_expression denotes positive
T10128 20374-20379 Protein denotes IRF-4
T10129 20473-20478 Protein denotes IRF-4
T10130 20380-20388 Gene_expression denotes positive
T10131 20452-20460 Entity denotes promoter
T10132 20479-20487 Gene_expression denotes negative
T10133 20598-20602 Protein denotes FasL
T10134 20767-20781 Protein denotes IRF-4 promoter
T10779 20803-20825 Protein denotes DNA methyltransferases
T10780 20830-20857 Protein denotes methyl-CpG-binding proteins
T10781 20885-20899 Protein denotes IRF-4 promoter
T10782 20789-20799 Gene_expression denotes expression
T10783 20789-20799 Gene_expression denotes expression
T10784 20869-20879 Positive_regulation denotes associated
T10785 20869-20879 Positive_regulation denotes associated
T10786 20931-20935 Protein denotes DNMT
T10787 20940-20943 Protein denotes MBP
T10788 21123-21137 Protein denotes IRF-4 promoter
T10789 20918-20927 Localization denotes abundance
T10790 20918-20927 Localization denotes abundance
T10791 21198-21202 Protein denotes DNMT
T10792 21204-21209 Protein denotes DNMT1
T10793 21211-21217 Protein denotes DNMT3A
T10794 21222-21228 Protein denotes DNMT3B
T10795 21233-21236 Protein denotes MBP
T10796 21238-21242 Protein denotes MBD1
T10797 21244-21248 Protein denotes MBD2
T10798 21250-21254 Protein denotes MBD4
T10799 21259-21263 Protein denotes MeCP
T10800 21184-21194 Regulation denotes difference
T10801 21270-21280 Transcription denotes expression
T10802 21270-21280 Transcription denotes expression
T10803 21270-21280 Transcription denotes expression
T10804 21270-21280 Transcription denotes expression
T10805 21270-21280 Transcription denotes expression
T10806 21270-21280 Transcription denotes expression
T10807 21270-21280 Transcription denotes expression
T10808 21270-21280 Transcription denotes expression
T10809 21270-21280 Transcription denotes expression
T10810 21184-21194 Regulation denotes difference
T10811 21184-21194 Regulation denotes difference
T10812 21184-21194 Regulation denotes difference
T10813 21184-21194 Regulation denotes difference
T10814 21184-21194 Regulation denotes difference
T10815 21184-21194 Regulation denotes difference
T10816 21184-21194 Regulation denotes difference
T10817 21184-21194 Regulation denotes difference
T10818 21184-21194 Regulation denotes difference
T10819 21414-21418 Protein denotes DNMT
T10820 21419-21423 Protein denotes MBPs
T10821 21479-21484 Protein denotes IRF-4
T10822 21391-21397 Transcription denotes levels
T10823 21391-21397 Transcription denotes levels
T10824 21629-21633 Protein denotes DNMT
T10825 21638-21646 Protein denotes MBP mRNA
T10826 21647-21660 Transcription denotes transcription
T10827 21647-21660 Transcription denotes transcription
T14312 21983-21988 Protein denotes IRF-4
T14313 21989-21999 Gene_expression denotes expression
T14314 21976-21982 Negative_regulation denotes absent
T14315 22118-22132 Protein denotes IRF-4 promoter
T14316 22168-22173 Protein denotes IRF-4
T14317 22434-22439 Protein denotes IRF-4
T14318 22174-22184 Gene_expression denotes expression
T14319 22440-22448 Gene_expression denotes positive
T14320 22453-22462 Gene_expression denotes -negative
T14321 22160-22164 Negative_regulation denotes lack
T14322 22833-22854 Protein denotes IRF-4 coding sequence
T14323 22963-22968 Protein denotes IRF-4
T14324 23049-23054 Protein denotes IFN-α
T14325 22969-22979 Gene_expression denotes expression
T14326 23009-23016 Positive_regulation denotes induced
T14327 23213-23218 Protein denotes IRF-4
T14328 23453-23458 Protein denotes IRF-4
T14329 23219-23229 Gene_expression denotes expression
T14330 23194-23209 Negative_regulation denotes down-regulation
T14331 23261-23264 Positive_regulation denotes due
T14332 23574-23589 Protein denotes IRF, IRF-7 (35)
T14333 23635-23640 Protein denotes IRF-4
T14334 23612-23623 Binding denotes interacting
T14335 23612-23623 Binding denotes interacting
T14336 23709-23714 Protein denotes IRF-4
T14337 23715-23725 Gene_expression denotes expression
T14338 23695-23705 Regulation denotes regulation
T14339 23859-23864 Protein denotes IRF-4
T14340 23940-23950 Protein denotes CpG motifs
T14341 23958-23972 Protein denotes IRF-4 promoter
T14342 23865-23875 Gene_expression denotes expression
T14343 24083-24088 Protein denotes IRF-4
T14344 24089-24099 Gene_expression denotes expression
T14345 24072-24079 Negative_regulation denotes absence
T14346 24192-24196 Protein denotes NFκB
T14347 24351-24356 Protein denotes IRF-4
T14348 24357-24365 Gene_expression denotes negative
T14349 24379-24388 Protein denotes CpG sites
T14350 24407-24411 Protein denotes NFκB
T14351 24419-24422 Protein denotes SP1
T14352 24483-24488 Protein denotes IRF-4
T14353 24489-24499 Gene_expression denotes expression
T14354 24469-24479 Regulation denotes regulation
T14355 24524-24537 Protein denotes NFκB elements
T14356 24564-24569 Protein denotes IRF-4
T14357 24583-24588 Protein denotes IRF-4
T14358 24626-24646 Protein denotes transactivator c-Rel
T14359 24672-24686 Protein denotes IRF-4 promoter
T14360 24570-24579 Positive_regulation denotes induction
T14361 24589-24599 Gene_expression denotes expression
T14362 24611-24618 Binding denotes binding
T14363 24556-24560 Regulation denotes role
T14364 24600-24607 Positive_regulation denotes depends
T14365 24747-24751 Protein denotes NFκB
T14366 24784-24796 Protein denotes NFκB protein
T14367 24769-24776 Binding denotes binding
T14368 24760-24768 Negative_regulation denotes inhibits
T14369 25015-25029 Protein denotes IRF-4 promoter
T14370 25090-25095 Protein denotes IRF-4
T14371 24998-25007 Negative_regulation denotes silencing
T14372 25096-25108 Regulation denotes deregulation
T14373 25310-25315 Protein denotes DNMT1
T14374 25292-25306 Positive_regulation denotes overexpression
T14375 25641-25646 Protein denotes DNMT1
T14376 25689-25697 Protein denotes p15INK4b
T14377 25647-25657 Gene_expression denotes expression
T14378 25813-25817 Protein denotes DNMT
T14379 25821-25824 Protein denotes MBP
T14380 25892-25897 Protein denotes IRF-4
T14381 25778-25788 Gene_expression denotes expression
T14382 25778-25788 Gene_expression denotes expression
T14383 25898-25908 Gene_expression denotes expression
T14384 25957-25962 Protein denotes IRF-4
T14385 26093-26098 Protein denotes IRF-4
T14386 25963-25973 Gene_expression denotes expression
T14387 26099-26109 Gene_expression denotes expression
T14388 26085-26089 Negative_regulation denotes loss
T14389 26337-26380 Protein denotes IRF, IFN consensus sequence binding protein
T14390 26382-26387 Protein denotes ICSBP
T14391 26388-26393 Protein denotes IRF-8
T14392 26315-26325 Gene_expression denotes expression
T14393 26315-26325 Gene_expression denotes expression
T14394 26315-26325 Gene_expression denotes expression
T14395 26399-26407 Negative_regulation denotes impaired
T14396 26399-26407 Negative_regulation denotes impaired
T14397 26399-26407 Negative_regulation denotes impaired
T14398 26475-26480 Protein denotes IRF-4
T14399 26499-26502 Protein denotes IRF
T14400 26528-26533 Protein denotes ICSBP
T14401 26627-26632 Protein denotes AzadC
T14402 26650-26655 Protein denotes ICSBP
T14403 26666-26671 Protein denotes ICSBP
T14404 26486-26490 Negative_regulation denotes loss
T14405 26534-26542 Gene_expression denotes negative
T14406 26633-26636 Gene_expression denotes has
T14407 26656-26662 Gene_expression denotes levels
T14408 26672-26680 Gene_expression denotes positive
T14409 26770-26774 Protein denotes IRFs
T14410 26776-26781 Protein denotes IRF-4
T14411 26838-26846 Protein denotes p15INK4b
T14412 26848-26856 Protein denotes p16INK4a
T14413 26860-26863 Protein denotes p53
T14414 26948-26958 Gene_expression denotes expression
T14415 27082-27087 Protein denotes IRF-4
T14416 27144-27177 Protein denotes IRF-4 promoter methylation status
T14417 27345-27371 Protein denotes immunoglobulin heavy-chain
T14418 27373-27376 Protein denotes IgH
T14419 27382-27387 Protein denotes IRF-4
T14420 27432-27437 Protein denotes IRF-4
T14421 27414-27428 Positive_regulation denotes overexpression
T14422 27388-27397 Positive_regulation denotes resulting
T14423 27469-27474 Protein denotes IRF-4
T14424 27475-27485 Gene_expression denotes expression
T14425 27730-27735 Protein denotes IRF-4
T14426 27756-27761 Protein denotes IRF-4
T14427 27850-27864 Protein denotes IRF-4−/− ICSBP
T14428 27902-27907 Protein denotes IRF-4
T14429 27737-27752 Negative_regulation denotes Down-regulation
T14430 27908-27921 Positive_regulation denotes up-regulation
T14431 28015-28029 Protein denotes IRF-4 promoter
T14432 28052-28057 Protein denotes IRF-4
T14433 28102-28107 Protein denotes IRF-4
T14434 28161-28175 Protein denotes IRF-4 promoter
T14435 28058-28068 Gene_expression denotes expression
T14436 28088-28098 Gene_expression denotes expression
T14437 28146-28157 Positive_regulation denotes consequence
T14438 28042-28051 Regulation denotes regulates
T3358 5991-6005 Protein denotes IRF-4 promoter
T3359 5973-5983 Gene_expression denotes Sequencing
T3360 6026-6031 Protein denotes IRF-4
T4295 6845-6850 Protein denotes IRF-4
T4296 7080-7085 Protein denotes IRF-4
T4297 7094-7110 Protein denotes reference gene β
T4298 7111-7116 Protein denotes actin
T4299 7296-7300 Protein denotes DNMT
T4300 7304-7307 Protein denotes MBP
T4301 7309-7321 Protein denotes DNMT1 DNMT3A
T4302 7323-7329 Protein denotes DNMT3B
T4303 7331-7335 Protein denotes MeCP
T4304 7337-7341 Protein denotes MBD1
T4305 7343-7347 Protein denotes MBD2
T4306 7352-7356 Protein denotes MBD4
T4307 7273-7283 Gene_expression denotes expression
T4308 7273-7283 Gene_expression denotes expression
T4309 7273-7283 Gene_expression denotes expression
T4310 7273-7283 Gene_expression denotes expression
T4311 7273-7283 Gene_expression denotes expression
T4312 7273-7283 Gene_expression denotes expression
T4313 7273-7283 Gene_expression denotes expression
T4314 7273-7283 Gene_expression denotes expression
T4315 7405-7418 Protein denotes IRF-4 protein
T4316 7419-7429 Gene_expression denotes expression
T4317 8346-8368 Protein denotes horseradish peroxidase
T4318 8414-8427 Protein denotes anti-goat IgG
T5649 11328-11342 Protein denotes IRF-4 promoter
T7732 14338-14343 Protein denotes IRF-4
T7733 14344-14354 Gene_expression denotes expression
T7734 14326-14334 Positive_regulation denotes Increase
T7735 14498-14503 Protein denotes IRF-4
T7736 14504-14514 Gene_expression denotes expression
T7737 14479-14494 Negative_regulation denotes down-regulation
T7738 14548-14553 Protein denotes IRF-4
T7739 14939-14944 Protein denotes IRF-4
T7740 14945-14958 Transcription denotes transcription
T7741 14925-14935 Positive_regulation denotes activation
T7742 15048-15053 Protein denotes IRF-4
T7743 15054-15067 Transcription denotes transcription
T7744 15072-15079 Positive_regulation denotes induced
T7745 15172-15181 Positive_regulation denotes increased
R615 T838 T839 themeOf interferon regulatory factor 4 gene,expression
R616 T839 T840 themeOf expression,Down-regulation
R617 T843 T845 themeOf interferon regulatory factor 4,deregulation
R618 T844 T846 themeOf IRF-4,deregulation
R619 T848 T849 themeOf IRF-4,expression
R620 T849 T850 themeOf expression,regulation
R621 T851 T854 themeOf IRF-4,expression
R622 T853 T855 themeOf IRF-4,transcription
R623 T854 T856 themeOf expression,altered
R624 T855 T857 themeOf transcription,influence
R625 T858 T859 themeOf IRF-4 mRNA,increase
R626 T860 T861 themeOf IRF-4,positive
R627 T862 T863 themeOf IRF-4,down-regulation
R628 T865 T866 themeOf IRF-4,expression
R629 T866 T867 themeOf expression,down-regulated
R2050 T2590 T2596 themeOf IRF-4,expression
R2051 T2591 T2597 themeOf ICSAT,expression
R2052 T2565 T2567 themeOf bcr,expression
R2053 T2566 T2568 themeOf abl,expression
R2054 T2592 T2598 themeOf Pip,expression
R2055 T2567 T2569 themeOf expression,leading
R2056 T2568 T2570 themeOf expression,leading
R2057 T2593 T2599 themeOf MUM1,expression
R2058 T2594 T2600 themeOf LSIRF,expression
R2059 T2573 T2576 themeOf interferon regulatory factor 4,expression
R2060 T2574 T2577 themeOf IRF-4,expression
R2061 T2576 T2578 themeOf expression,impaired
R2062 T2577 T2579 themeOf expression,impaired
R2063 T2595 T2601 themeOf IRF-4,positive
R2064 T2580 T2581 themeOf IRF-4,silencing
R2065 T2603 T2605 themeOf IRF-4,expression
R2066 T2584 T2587 themeOf IFNs,regulation
R2067 T2585 T2588 themeOf interleukins,regulation
R2068 T2586 T2589 themeOf MHC class I/II,regulation
R2069 T2604 T2606 causeOf IFNs,induced
R2070 T2605 T2606 themeOf expression,induced
R2071 T2607 T2609 themeOf IRF-4,deletion
R2072 T2608 T2610 themeOf IRF-4,expression
R2073 T2620 T2623 themeOf c-abl,expression
R2077 T2621 T2624 themeOf bcr gene,expression
R2078 T2623 T2625 themeOf expression,regulate
R2080 T2624 T2626 themeOf expression,regulate
R2082 T2627 T2629 themeOf DNA methyltransferases,overexpression
R2084 T2628 T2630 themeOf DNMTs,overexpression
R2086 T2629 T2631 themeOf overexpression,overexpression
R2090 T2630 T2632 themeOf overexpression,overexpression
R2094 T2633 T2636 themeOf Methyl-CpG-binding proteins,binding
R2096 T2633 T2638 themeOf Methyl-CpG-binding proteins,binding
R2097 T2633 T2639 causeOf Methyl-CpG-binding proteins,inhibit
R2098 T2633 T2640 causeOf Methyl-CpG-binding proteins,inhibit
R2099 T2633 T2641 causeOf Methyl-CpG-binding proteins,inhibit
R2100 T2634 T2637 themeOf MBPs,binding
R2103 T2634 T2638 themeOf MBPs,binding
R2104 T2634 T2642 causeOf MBPs,inhibit
R2106 T2634 T2643 causeOf MBPs,inhibit
R2107 T2634 T2644 causeOf MBPs,inhibit
R2108 T2635 T2636 Site promoter,binding
R2109 T2635 T2637 Site promoter,binding
R2114 T2635 T2638 Site promoter,binding
R2116 T2636 T2639 themeOf binding,inhibit
R2119 T2636 T2642 themeOf binding,inhibit
R2121 T2637 T2640 themeOf binding,inhibit
R2122 T2637 T2643 themeOf binding,inhibit
R2123 T2638 T2641 themeOf binding,inhibit
R2124 T2638 T2644 themeOf binding,inhibit
R2125 T2645 T2646 themeOf IRF-4 gene,expression
R2126 T2646 T2647 themeOf expression,silencing
R2127 T2648 T2649 themeOf IRF-4 promoter region,-negative
R2709 T3358 T3359 themeOf IRF-4 promoter,Sequencing
R3506 T4304 T4312 themeOf MBD1,expression
R3507 T4305 T4313 themeOf MBD2,expression
R3508 T4306 T4314 themeOf MBD4,expression
R3509 T4315 T4316 themeOf IRF-4 protein,expression
R5116 T6107 T6108 themeOf renilla luciferase gene,expressing
R5117 T6107 T6109 themeOf renilla luciferase gene,transientlyco-expressed
R5118 T6111 T6112 themeOf IRF-4 promoter,activation
R5722 T6847 T6848 themeOf IRF-4,expression
R5723 T6848 T6849 themeOf expression,Absence
R5724 T6849 T6850 themeOf Absence,due
R5725 T6851 T6852 themeOf IRF-4,expression
R5726 T6852 T6853 themeOf expression,lack
R5727 T6854 T6867 themeOf IRF-4,expression
R5728 T6855 T6868 themeOf bcr,positive
R5729 T6856 T6869 themeOf abl,positive
R5730 T6857 T6870 themeOf bcr,positve
R5731 T6858 T6871 themeOf abl,positve
R5732 T6861 T6872 themeOf bcr,positve
R5733 T6862 T6873 themeOf abl,positve
R5734 T6863 T6874 themeOf bcr,positive
R5735 T6864 T6875 themeOf abl,positive
R5736 T6865 T6876 themeOf bcr,positive
R5737 T6866 T6877 themeOf abl,positive
R5738 T6879 T6880 themeOf IRF-4,expression
R5739 T6880 T6881 themeOf expression,absence
R5740 T6882 T6883 themeOf IRF-4,positive
R5741 T6884 T6885 themeOf IRF-4,expression
R5742 T6885 T6886 themeOf expression,affect
R6448 T7732 T7733 themeOf IRF-4,expression
R6449 T7733 T7734 themeOf expression,Increase
R6450 T7735 T7736 themeOf IRF-4,expression
R6451 T7736 T7737 themeOf expression,down-regulation
R6452 T7739 T7740 themeOf IRF-4,transcription
R6453 T7740 T7741 themeOf transcription,activation
R6454 T7742 T7743 themeOf IRF-4,transcription
R6455 T7743 T7744 themeOf transcription,induced
R6456 T7743 T7745 themeOf transcription,increased
R6457 T7748 T7749 themeOf IRF-4 protein,expression
R6458 T7749 T7750 themeOf expression,induction
R6459 T7751 T7754 themeOf IRF-4,positive
R6460 T7753 T7755 themeOf IRF-4,expression
R6461 T7755 T7756 themeOf expression,effect
R6462 T7757 T7758 themeOf IRF-4 mRNA,increased
R6463 T7759 T7762 themeOf IRF-4,expression
R6464 T7762 T7763 themeOf expression,control
R7038 T8448 T8449 themeOf IRF-4 gene,expression
R7039 T8454 T8456 themeOf HpaII,digestion
R7040 T8455 T8457 themeOf Bsp143II,digestion
R7041 T8458 T8459 themeOf IRF-4,positive
R7042 T8461 T8463 themeOf IRF-4,transcription
R8008 T9604 T9605 themeOf IRF-4,positive
R8009 T9607 T9608 themeOf IRF-4,expression
R8010 T9613 T9614 themeOf IRF-4,expression
R8011 T9614 T9615 themeOf expression,regulation
R8012 T9615 T9616 themeOf regulation,involvement
R8400 T10121 T10122 themeOf IRF-4 promoter-reporter construct,decreases
R8401 T10125 T10127 themeOf IRF-4,positive
R8402 T10128 T10130 themeOf IRF-4,positive
R8403 T10129 T10132 themeOf IRF-4,negative
R8927 T10779 T10782 themeOf DNA methyltransferases,expression
R8928 T10780 T10783 themeOf methyl-CpG-binding proteins,expression
R8929 T10782 T10784 themeOf expression,associated
R8930 T10783 T10785 themeOf expression,associated
R8931 T10786 T10789 themeOf DNMT,abundance
R8932 T10787 T10790 themeOf MBP,abundance
R8933 T10791 T10800 themeOf DNMT,difference
R8934 T10791 T10801 themeOf DNMT,expression
R8935 T10792 T10802 themeOf DNMT1,expression
R8936 T10793 T10803 themeOf DNMT3A,expression
R8937 T10794 T10804 themeOf DNMT3B,expression
R8938 T10795 T10805 themeOf MBP,expression
R8939 T10796 T10806 themeOf MBD1,expression
R8940 T10797 T10807 themeOf MBD2,expression
R8941 T10798 T10808 themeOf MBD4,expression
R8942 T10799 T10809 themeOf MeCP,expression
R8943 T10801 T10810 themeOf expression,difference
R8944 T10802 T10811 themeOf expression,difference
R8945 T10803 T10812 themeOf expression,difference
R8946 T10804 T10813 themeOf expression,difference
R8947 T10805 T10814 themeOf expression,difference
R8948 T10806 T10815 themeOf expression,difference
R8949 T10807 T10816 themeOf expression,difference
R8950 T10808 T10817 themeOf expression,difference
R8951 T10809 T10818 themeOf expression,difference
R8952 T10819 T10822 themeOf DNMT,levels
R8953 T10820 T10823 themeOf MBPs,levels
R8954 T10824 T10826 themeOf DNMT,transcription
R8955 T10825 T10827 themeOf MBP mRNA,transcription
R11847 T14312 T14313 themeOf IRF-4,expression
R11849 T14313 T14314 themeOf expression,absent
R11850 T14316 T14318 themeOf IRF-4,expression
R11852 T14317 T14319 themeOf IRF-4,positive
R11853 T14317 T14320 themeOf IRF-4,-negative
R11854 T14318 T14321 themeOf expression,lack
R11856 T14323 T14325 themeOf IRF-4,expression
R11857 T14324 T14326 causeOf IFN-α,induced
R11858 T14325 T14326 themeOf expression,induced
R11860 T14327 T14329 themeOf IRF-4,expression
R11862 T14329 T14330 themeOf expression,down-regulation
R11863 T14330 T14331 themeOf down-regulation,due
R11864 T14370 T14372 themeOf IRF-4,deregulation
R11865 T14332 T14335 themeOf "IRF, IRF-7 (35)",interacting
R11866 T14333 T14334 themeOf IRF-4,interacting
R11867 T14333 T14335 themeOf IRF-4,interacting
R11868 T14336 T14337 themeOf IRF-4,expression
R11869 T14337 T14338 themeOf expression,regulation
R11870 T14339 T14342 themeOf IRF-4,expression
R11871 T14373 T14374 themeOf DNMT1,overexpression
R11872 T14343 T14344 themeOf IRF-4,expression
R11873 T14344 T14345 themeOf expression,absence
R11874 T14375 T14377 themeOf DNMT1,expression
R11875 T14347 T14348 themeOf IRF-4,negative
R11876 T14378 T14381 themeOf DNMT,expression
R11877 T14352 T14353 themeOf IRF-4,expression
R11878 T14353 T14354 themeOf expression,regulation
R11879 T14379 T14382 themeOf MBP,expression
R11880 T14380 T14383 themeOf IRF-4,expression
R11881 T14355 T14363 causeOf NFκB elements,role
R11882 T14356 T14360 themeOf IRF-4,induction
R11883 T14357 T14361 themeOf IRF-4,expression
R11884 T14358 T14362 themeOf transactivator c-Rel,binding
R11885 T14384 T14386 themeOf IRF-4,expression
R11886 T14360 T14363 themeOf induction,role
R11887 T14361 T14364 themeOf expression,depends
R11888 T14362 T14364 causeOf binding,depends
R11889 T14385 T14387 themeOf IRF-4,expression
R11890 T14366 T14367 themeOf NFκB protein,binding
R11891 T14367 T14368 themeOf binding,inhibits
R11892 T14387 T14388 themeOf expression,loss
R11893 T14369 T14371 themeOf IRF-4 promoter,silencing
R11894 T14389 T14392 themeOf "IRF, IFN consensus sequence binding protein",expression
R11895 T14390 T14393 themeOf ICSBP,expression
R11896 T14391 T14394 themeOf IRF-8,expression
R11897 T14392 T14395 themeOf expression,impaired
R11898 T14393 T14396 themeOf expression,impaired
R11899 T14394 T14397 themeOf expression,impaired
R11900 T14399 T14404 themeOf IRF,loss
R11901 T14400 T14405 themeOf ICSBP,negative
R11902 T14401 T14406 themeOf AzadC,has
R11903 T14402 T14407 themeOf ICSBP,levels
R11904 T14403 T14408 themeOf ICSBP,positive
R11905 T14410 T14414 themeOf IRF-4,expression
R11911 T14420 T14421 themeOf IRF-4,overexpression
R11916 T14421 T14422 themeOf overexpression,resulting
R11919 T14423 T14424 themeOf IRF-4,expression
R11922 T14426 T14429 themeOf IRF-4,Down-regulation
R11924 T14428 T14430 themeOf IRF-4,up-regulation
R11925 T14432 T14435 themeOf IRF-4,expression
R11927 T14433 T14436 themeOf IRF-4,expression
R11928 T14435 T14438 themeOf expression,regulates
R11931 T14436 T14437 themeOf expression,consequence
R3501 T4299 T4307 themeOf DNMT,expression
R3502 T4300 T4308 themeOf MBP,expression
R3503 T4301 T4309 themeOf DNMT1 DNMT3A,expression
R3504 T4302 T4310 themeOf DNMT3B,expression
R3505 T4303 T4311 themeOf MeCP,expression

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T97 1376-1381 Protein denotes IRF-4
T98 1382-1390 Gene_expression denotes positive
T99 1467-1472 Protein denotes IRF-4
T100 1473-1488 Negative_regulation denotes down-regulation
T101 1698-1703 Protein denotes IRF-4
T102 1752-1766 Negative_regulation denotes down-regulated true
T103 1767-1772 Protein denotes IRF-4
T104 1773-1783 Gene_expression denotes expression
T1004 2172-2179 Positive_regulation denotes leading
T1005 2183-2193 Gene_expression denotes expression
T1006 2199-2218 Protein denotes bcr-abl fusion gene
T1007 2278-2290 Protein denotes interferon α
T1008 2292-2297 Protein denotes IFN-α
T1009 2446-2454 Negative_regulation denotes impaired
T1010 2455-2465 Gene_expression denotes expression
T1011 2473-2503 Protein denotes interferon regulatory factor 4
T1012 2505-2510 Protein denotes IRF-4
T1013 2554-2559 Protein denotes IFN-α
T1014 2592-2601 Negative_regulation denotes silencing
T1015 2605-2610 Protein denotes IRF-4
T1016 2938-2943 Protein denotes IRF-4
T1017 2945-2950 Protein denotes ICSAT
T1018 2951-2954 Protein denotes Pip
T1019 2955-2959 Protein denotes MUM1
T1020 2960-2965 Protein denotes LSIRF
T1021 3002-3012 Gene_expression denotes expression
T1022 3071-3076 Protein denotes IRF-4
T1023 3077-3085 Gene_expression denotes positive
T1024 3121-3131 Gene_expression denotes expression
T1025 3135-3140 Protein denotes IRF-4
T1026 3151-3158 Positive_regulation denotes induced true
T1027 3355-3363 Negative_regulation denotes deletion
T1028 3367-3372 Protein denotes IRF-4
T1029 3466-3476 Gene_expression denotes expression
T1030 3480-3485 Protein denotes IRF-4
T1031 3571-3576 Protein denotes IRF-4
T1032 4167-4171 Protein denotes MGMT
T1033 4173-4177 Protein denotes DAPK
T1034 4179-4185 Protein denotes p14ARF
T1035 4187-4195 Protein denotes p15INK4b
T1036 4197-4205 Protein denotes p16INK4a
T1037 4207-4212 Protein denotes BRCA1
T1038 4214-4219 Protein denotes CDH13
T1039 4224-4230 Protein denotes APAF-1
T1040 4272-4280 Regulation denotes regulate
T1041 4272-4280 Regulation denotes regulate
T1042 4281-4291 Gene_expression denotes expression
T1043 4281-4291 Gene_expression denotes expression
T1044 4299-4304 Protein denotes c-abl
T1045 4310-4313 Protein denotes bcr
T1046 4376-4381 Protein denotes c-abl
T1047 4937-4942 Protein denotes IRF-4
T1048 4948-4958 Gene_expression denotes expression
T1049 4959-4968 Negative_regulation denotes silencing
T1050 5004-5009 Protein denotes IRF-4
T1051 5078-5083 Protein denotes IRF-4
T1052 5084-5092 Gene_expression denotes positive
T1053 5098-5106 Gene_expression denotes negative true
T3424 6851-6866 Transcription denotes transcriptional
T3425 7273-7283 Gene_expression denotes expression true
T3426 7419-7429 Gene_expression denotes expression true
T3427 7052-7066 Transcription denotes RNA expression
T3428 7052-7066 Transcription denotes RNA expression
T3429 7273-7283 Gene_expression denotes expression true
T3430 7273-7283 Gene_expression denotes expression true
T3431 7273-7283 Gene_expression denotes expression true
T3432 7273-7283 Gene_expression denotes expression true
T3433 7273-7283 Gene_expression denotes expression true
T3434 7273-7283 Gene_expression denotes expression true
T3435 6845-6850 Protein denotes IRF-4
T3436 7352-7356 Protein denotes MBD4
T3437 7405-7410 Protein denotes IRF-4
T3438 8615-8620 Protein denotes IRF-4
T3439 8621-8626 Protein denotes ICSAT
T3440 8628-8632 Protein denotes M-17
T3441 8692-8699 Protein denotes β-actin
T3442 7080-7085 Protein denotes IRF-4
T3443 7109-7116 Protein denotes β-actin
T3444 7315-7321 Protein denotes DNMT3A
T3445 7323-7329 Protein denotes DNMT3B
T3446 7331-7335 Protein denotes MeCP
T3447 7337-7341 Protein denotes MBD1
T3448 7343-7347 Protein denotes MBD2
T3449 7309-7314 Protein denotes DNMT1
T6190 13187-13197 Gene_expression denotes expression
T6191 13292-13297 Protein denotes IRF-4
T6192 13298-13308 Gene_expression denotes expression true
T6193 13391-13398 Protein denotes bcr-abl
T6194 13399-13407 Gene_expression denotes positive
T6195 13430-13437 Protein denotes bcr-abl
T6196 13438-13445 Gene_expression denotes positve
T6197 13510-13517 Protein denotes bcr-abl
T6198 13518-13525 Gene_expression denotes positve
T6199 13563-13570 Protein denotes bcr-abl
T6200 13571-13579 Gene_expression denotes positive
T6201 13666-13673 Protein denotes bcr-abl
T6202 13674-13682 Gene_expression denotes positive
T6203 13740-13745 Protein denotes IRF-4
T6204 13782-13789 Negative_regulation denotes absence
T6205 13793-13798 Protein denotes IRF-4
T6206 13799-13809 Gene_expression denotes expression
T6207 13964-13969 Protein denotes IRF-4
T6208 13970-13978 Gene_expression denotes positive
T6209 13994-13999 Protein denotes IRF-4
T6210 14000-14008 Gene_expression denotes negative true
T6211 14300-14306 Regulation denotes affect true true
T6212 14307-14312 Protein denotes IRF-4
T6213 14313-14323 Gene_expression denotes expression
T6976 14326-14334 Positive_regulation denotes Increase
T6977 14338-14343 Protein denotes IRF-4
T6978 14344-14354 Gene_expression denotes expression
T6979 14498-14503 Protein denotes IRF-4
T6980 14504-14514 Gene_expression denotes expression
T6981 14548-14553 Protein denotes IRF-4
T6982 14925-14935 Positive_regulation denotes activation
T6983 14939-14944 Protein denotes IRF-4
T6984 14945-14958 Transcription denotes transcription
T6985 15048-15053 Protein denotes IRF-4
T6986 15054-15067 Transcription denotes transcription
T6987 15072-15079 Positive_regulation denotes induced
T6988 15172-15181 Positive_regulation denotes increased
T6989 15255-15260 Protein denotes IRF-4
T6990 15261-15272 Transcription denotes transcripts
T6991 15465-15470 Protein denotes IRF-4
T6992 15533-15538 Protein denotes IRF-4
T6993 15539-15547 Gene_expression denotes positive
T6994 15603-15609 Regulation denotes effect true
T6995 15613-15618 Protein denotes IRF-4
T6996 15619-15629 Gene_expression denotes expression
T6997 15712-15721 Positive_regulation denotes increased
T6998 15726-15731 Protein denotes IRF-4
T6999 15732-15742 Transcription denotes mRNA level
T8548 19216-19224 Gene_expression denotes positive
T8549 19415-19422 Negative_regulation denotes absence
T8550 19426-19431 Protein denotes IRF-4
T8551 19432-19442 Gene_expression denotes expression
T8552 19542-19547 Protein denotes IRF-4
T8553 19548-19556 Gene_expression denotes positive
T8554 19565-19570 Protein denotes IRF-4
T8555 19571-19579 Gene_expression denotes negative true
T8556 19703-19713 Regulation denotes regulation true
T8557 19717-19722 Protein denotes IRF-4
T8558 19723-19733 Gene_expression denotes expression
T9682 20374-20379 Protein denotes IRF-4
T9683 20380-20388 Gene_expression denotes positive
T9684 20438-20448 Negative_regulation denotes abrogation
T9685 20452-20460 Entity denotes promoter
T9686 20473-20478 Protein denotes IRF-4
T9687 20479-20487 Gene_expression denotes negative true
T9688 20598-20602 Protein denotes FasL
T9689 20767-20772 Protein denotes IRF-4
T10212 21265-21280 Transcription denotes mRNA expression
T10213 21265-21280 Transcription denotes mRNA expression
T10214 21265-21280 Transcription denotes mRNA expression
T10215 21265-21280 Transcription denotes mRNA expression
T10216 21289-21294 Protein denotes IRF-4
T10217 21295-21303 Gene_expression denotes positive
T10218 21309-21317 Gene_expression denotes negative true
T10219 21386-21397 Transcription denotes mRNA levels
T10220 21386-21397 Transcription denotes mRNA levels
T10221 21386-21397 Transcription denotes mRNA levels
T10222 21386-21397 Transcription denotes mRNA levels
T10223 21386-21397 Transcription denotes mRNA levels
T10224 21386-21397 Transcription denotes mRNA levels
T10225 21386-21397 Transcription denotes mRNA levels
T10226 21443-21453 Transcription denotes expression
T10227 21443-21453 Transcription denotes expression
T10228 21443-21453 Transcription denotes expression
T10229 21443-21453 Transcription denotes expression
T10230 21443-21453 Transcription denotes expression
T10231 21443-21453 Transcription denotes expression
T10232 21443-21453 Transcription denotes expression
T10233 21479-21484 Protein denotes IRF-4
T10234 21567-21572 Protein denotes IRF-4
T10235 21573-21581 Gene_expression denotes positive
T10236 21587-21595 Gene_expression denotes negative true
T10237 21647-21660 Transcription denotes transcription
T10238 21647-21660 Transcription denotes transcription
T10239 21647-21660 Transcription denotes transcription
T10240 21647-21660 Transcription denotes transcription
T10241 21647-21660 Transcription denotes transcription
T10242 21647-21660 Transcription denotes transcription
T10243 21647-21660 Transcription denotes transcription
T11161 22747-22767 Entity denotes primer binding sites
T11162 22833-22838 Protein denotes IRF-4
T11163 22963-22968 Protein denotes IRF-4
T11164 22969-22979 Gene_expression denotes expression
T11165 23009-23016 Positive_regulation denotes induced
T11166 23049-23054 Protein denotes IFN-α
T11167 23194-23209 Negative_regulation denotes down-regulation
T11168 23213-23218 Protein denotes IRF-4
T11169 23219-23229 Gene_expression denotes expression
T11170 23261-23264 Positive_regulation denotes due true
T11171 23337-23350 Gene_expression denotes re-expression
T11172 23390-23396 Positive_regulation denotes result true
T11173 23453-23458 Protein denotes IRF-4
T11174 23579-23584 Protein denotes IRF-7
T11175 23598-23602 Protein denotes PU.1
T11176 23612-23623 Binding denotes interacting
T11177 23635-23640 Protein denotes IRF-4
T11178 23695-23705 Regulation denotes regulation
T11179 23709-23714 Protein denotes IRF-4
T11180 23715-23725 Gene_expression denotes expression
T11181 23859-23864 Protein denotes IRF-4
T11182 23865-23875 Gene_expression denotes expression
T11183 23958-23963 Protein denotes IRF-4
T11184 24056-24063 Positive_regulation denotes account true
T11185 24072-24079 Negative_regulation denotes absence
T11186 24083-24088 Protein denotes IRF-4
T11187 24089-24099 Gene_expression denotes expression
T11188 24313-24318 Protein denotes IRF-4
T11189 24319-24327 Gene_expression denotes positive
T11190 24351-24356 Protein denotes IRF-4
T11191 24461-24465 Regulation denotes role true
T11192 24469-24479 Regulation denotes regulation
T11193 24483-24488 Protein denotes IRF-4
T11194 24489-24499 Gene_expression denotes expression
T11195 24524-24537 Entity denotes NFκB elements
T11196 24546-24560 Regulation denotes important role
T11197 24564-24569 Protein denotes IRF-4
T11198 24570-24579 Positive_regulation denotes induction
T11199 24583-24588 Protein denotes IRF-4
T11200 24589-24599 Gene_expression denotes expression
T11201 24600-24607 Positive_regulation denotes depends
T11202 24611-24618 Binding denotes binding
T11203 24641-24646 Protein denotes c-Rel
T11204 24672-24677 Protein denotes IRF-4
T11205 24736-24739 Entity denotes CpG
T11206 24747-24759 Entity denotes NFκB element
T11207 24760-24768 Negative_regulation denotes inhibits
T11208 24769-24776 Binding denotes binding
T11209 24883-24888 Protein denotes IRF-4
T11210 24889-24897 Gene_expression denotes positive
T11211 24903-24911 Gene_expression denotes negative true
T11212 24998-25007 Negative_regulation denotes silencing
T11213 25015-25020 Protein denotes IRF-4
T11214 25021-25029 Entity denotes promoter
T11215 25090-25095 Protein denotes IRF-4
T11216 25096-25108 Regulation denotes deregulation true
T11217 25292-25306 Positive_regulation denotes overexpression
T11218 25310-25315 Protein denotes DNMT1
T11219 25641-25646 Protein denotes DNMT1
T11220 25647-25657 Gene_expression denotes expression
T11221 25689-25697 Protein denotes p15INK4b
T11222 25892-25897 Protein denotes IRF-4
T11223 25898-25908 Gene_expression denotes expression
T11224 25957-25962 Protein denotes IRF-4
T11225 25963-25973 Gene_expression denotes expression
T11226 26085-26089 Negative_regulation denotes loss
T11227 26093-26098 Protein denotes IRF-4
T11228 26099-26109 Gene_expression denotes expression
T11229 26315-26325 Gene_expression denotes expression
T11230 26342-26380 Protein denotes IFN consensus sequence binding protein
T11231 26382-26387 Protein denotes ICSBP
T11232 26388-26393 Protein denotes IRF-8
T11233 26399-26407 Negative_regulation denotes impaired
T11234 26475-26480 Protein denotes IRF-4
T11235 26486-26490 Negative_regulation denotes loss
T11236 26516-26524 Negative_regulation denotes reverted true
T11237 26528-26533 Protein denotes ICSBP
T11238 26534-26542 Gene_expression denotes negative true
T11239 26640-26646 Regulation denotes effect true
T11240 26650-26655 Protein denotes ICSBP
T11241 26656-26662 Gene_expression denotes levels
T11242 26666-26671 Protein denotes ICSBP
T11243 26672-26680 Gene_expression denotes positive
T11244 26776-26781 Protein denotes IRF-4
T11245 26838-26846 Protein denotes p15INK4b
T11246 26848-26856 Protein denotes p16INK4a
T11247 26860-26863 Protein denotes p53
T11248 26948-26958 Gene_expression denotes expression
T11249 26959-26966 Regulation denotes changes
T11250 27082-27087 Protein denotes IRF-4
T11251 27144-27149 Protein denotes IRF-4
T11252 27192-27197 Protein denotes IRF-4
T11253 27345-27371 Protein denotes immunoglobulin heavy-chain
T11254 27373-27376 Protein denotes IgH
T11255 27382-27387 Protein denotes IRF-4
T11256 27388-27397 Positive_regulation denotes resulting
T11257 27414-27428 Positive_regulation denotes overexpression
T11258 27432-27437 Protein denotes IRF-4
T11259 27469-27474 Protein denotes IRF-4
T11260 27475-27485 Gene_expression denotes expression
T11261 27730-27735 Protein denotes IRF-4
T11262 27737-27752 Negative_regulation denotes Down-regulation
T11263 27756-27761 Protein denotes IRF-4
T11264 27850-27855 Protein denotes IRF-4
T11265 27859-27864 Protein denotes ICSBP
T11266 27875-27884 Gene_expression denotes knock-out true
T11267 27875-27884 Gene_expression denotes knock-out true
T11268 27902-27907 Protein denotes IRF-4
T11269 27908-27921 Positive_regulation denotes up-regulation
T11270 28015-28020 Protein denotes IRF-4
T11271 28042-28051 Regulation denotes regulates true
T11272 28052-28057 Protein denotes IRF-4
T11273 28058-28068 Gene_expression denotes expression
T11274 28088-28098 Gene_expression denotes expression
T11275 28102-28107 Protein denotes IRF-4
T11276 28146-28157 Positive_regulation denotes consequence true
T11277 28161-28166 Protein denotes IRF-4
T4931 11328-11333 Protein denotes IRF-4
T10198 20885-20890 Protein denotes IRF-4
T10199 20958-20966 Entity denotes promoter
T10200 20967-20977 Regulation denotes regulation
T10201 21123-21128 Protein denotes IRF-4
T10202 21204-21209 Protein denotes DNMT1
T10203 21211-21217 Protein denotes DNMT3A
T10204 21222-21228 Protein denotes DNMT3B
T10205 21238-21242 Protein denotes MBD1
T10206 21244-21248 Protein denotes MBD2
T10207 21250-21254 Protein denotes MBD4
T10208 21259-21263 Protein denotes MeCP
T10209 21265-21280 Transcription denotes mRNA expression
T10210 21265-21280 Transcription denotes mRNA expression
T10211 21265-21280 Transcription denotes mRNA expression
T6184 13058-13065 Negative_regulation denotes Absence
T6185 13069-13074 Protein denotes IRF-4
T6186 13075-13085 Gene_expression denotes expression
T6187 13111-13114 Positive_regulation denotes due true
T6188 13173-13177 Negative_regulation denotes lack
T6189 13181-13186 Protein denotes IRF-4
T5673 12107-12112 Protein denotes IRF-4
T5674 12231-12244 Protein denotes CpG Methylase
T5675 12246-12253 Protein denotes M.Sss I
T5676 12414-12424 Protein denotes luciferase
T5677 12569-12579 Gene_expression denotes expressing
T5678 12592-12602 Protein denotes luciferase
T5679 12627-12636 Gene_expression denotes expressed
T5680 12779-12789 Protein denotes luciferase
T5681 12877-12882 Protein denotes IRF-4
T5682 12883-12891 Entity denotes promoter
T5683 12892-12902 Positive_regulation denotes activation
T2705 5476-5481 Protein denotes IRF-4
T2706 5482-5490 Gene_expression denotes negative true
T9674 19781-19786 Protein denotes IRF-4
T9675 19905-19910 Protein denotes IRF-4
T9676 19968-19973 Protein denotes IRF-4
T9677 20204-20209 Protein denotes IRF-4
T9678 20233-20242 Negative_regulation denotes decreased
T9679 20243-20251 Entity denotes promoter
T9680 20264-20269 Protein denotes IRF-4
T9681 20270-20278 Gene_expression denotes positive
T7817 16035-16040 Protein denotes IRF-4
T7818 16146-16151 Protein denotes IRF-4
T7819 16157-16167 Gene_expression denotes expression
T7820 16539-16544 Protein denotes IRF-4
T7821 16828-16833 Protein denotes IRF-4
T7822 16834-16842 Gene_expression denotes negative true
T7823 17018-17023 Protein denotes IRF-4
T7824 17024-17032 Gene_expression denotes positive
T7825 17145-17150 Protein denotes IRF-4
T7826 17151-17159 Gene_expression denotes positive
T7827 17357-17362 Protein denotes IRF-4
T7828 17363-17376 Transcription denotes transcription
T7829 17513-17518 Protein denotes IRF-4
T7830 17519-17527 Gene_expression denotes negative true
T11139 21976-21982 Negative_regulation denotes absent
T11140 21983-21988 Protein denotes IRF-4
T11141 21989-21999 Gene_expression denotes expression
T11142 22118-22123 Protein denotes IRF-4
T11143 22160-22164 Negative_regulation denotes lack
T11144 22168-22173 Protein denotes IRF-4
T11145 22174-22184 Gene_expression denotes expression
T11146 22345-22356 Positive_regulation denotes responsible true
T11147 22361-22367 Negative_regulation denotes absent
T11148 22368-22373 Protein denotes IRF-4
T11149 22374-22384 Gene_expression denotes expression
T11150 22434-22439 Protein denotes IRF-4
T11151 22440-22448 Gene_expression denotes positive
T11152 22454-22462 Gene_expression denotes negative true
T11153 22532-22537 Protein denotes IRF-4
T11154 22538-22546 Gene_expression denotes negative true
T11155 22551-22559 Gene_expression denotes positive
T11156 22630-22636 Regulation denotes change true
T11157 22656-22690 Entity denotes transcription factor binding sites
T11158 22715-22721 Regulation denotes affect true
T11159 22715-22721 Regulation denotes affect true
T11160 22726-22743 Entity denotes restriction sites
T4349 9440-9445 Protein denotes IRF-4
T71 0-15 Negative_regulation denotes Down-regulation
T72 19-49 Protein denotes interferon regulatory factor 4
T73 55-65 Gene_expression denotes expression
T74 169-172 Protein denotes bcr
T75 173-176 Protein denotes abl
T76 316-328 Regulation denotes deregulation true
T77 378-408 Protein denotes interferon regulatory factor 4
T78 410-415 Protein denotes IRF-4
T79 669-674 Protein denotes IRF-4
T80 731-741 Regulation denotes regulation true
T81 745-750 Protein denotes IRF-4
T82 751-761 Gene_expression denotes expression
T83 869-876 Regulation denotes altered
T84 877-882 Protein denotes IRF-4
T85 883-893 Gene_expression denotes expression
T86 922-927 Protein denotes IRF-4
T87 983-992 Regulation denotes influence
T88 993-998 Protein denotes IRF-4
T89 999-1012 Transcription denotes transcription
T90 1034-1039 Protein denotes IRF-4
T91 1040-1048 Gene_expression denotes negative true
T92 1145-1153 Positive_regulation denotes resulted
T93 1193-1201 Positive_regulation denotes increase
T94 1205-1210 Protein denotes IRF-4
T95 1350-1355 Protein denotes IRF-4
T96 1356-1364 Gene_expression denotes negative true
T7000 15828-15835 Regulation denotes control true
T7001 15836-15841 Protein denotes IRF-4
T7002 15842-15852 Gene_expression denotes expression
T7003 15945-15950 Protein denotes IRF-4
T8532 17562-17567 Protein denotes IRF-4
T3051 5991-5996 Protein denotes IRF-4
T3052 6026-6031 Protein denotes IRF-4
T8533 17672-17677 Protein denotes IRF-4
T8534 18302-18307 Protein denotes IRF-4
T8535 18324-18329 Protein denotes IRF-4
T8536 18330-18338 Gene_expression denotes positive
T8537 18367-18372 Protein denotes IRF-4
T8538 18393-18398 Protein denotes IRF-4
T8539 18399-18407 Gene_expression denotes negative true
T8540 18466-18471 Protein denotes IRF-4
T8541 18486-18491 Protein denotes IRF-4
T8542 18492-18500 Gene_expression denotes positive
T8543 18548-18553 Protein denotes IRF-4
T8544 18554-18562 Gene_expression denotes negative true
T8545 19096-19101 Protein denotes IRF-4
T8546 19102-19110 Gene_expression denotes negative true
T8547 19210-19215 Protein denotes IRF-4
R751 T1011 T1010 themeOf interferon regulatory factor 4,expression
R752 T1012 T1011 equivalentTo IRF-4,interferon regulatory factor 4
R753 T1015 T1014 themeOf IRF-4,silencing
R754 T1016 T1021 themeOf IRF-4,expression
R755 T1017 T1016 equivalentTo ICSAT,IRF-4
R756 T1018 T1016 equivalentTo Pip,IRF-4
R757 T1019 T1016 equivalentTo MUM1,IRF-4
R758 T1020 T1016 equivalentTo LSIRF,IRF-4
R759 T1022 T1023 themeOf IRF-4,positive
R760 T1024 T1026 themeOf expression,induced
R761 T1025 T1024 themeOf IRF-4,expression
R762 T1028 T1027 themeOf IRF-4,deletion
R763 T1030 T1029 themeOf IRF-4,expression
R764 T1042 T1041 themeOf expression,regulate
R765 T1043 T1040 themeOf expression,regulate
R766 T1044 T1042 themeOf c-abl,expression
R767 T1045 T1043 themeOf bcr,expression
R768 T1047 T1048 themeOf IRF-4,expression
R769 T1048 T1049 themeOf expression,silencing
R749 T1008 T1007 equivalentTo IFN-α,interferon α
R750 T1010 T1009 themeOf expression,impaired
R770 T1051 T1052 themeOf IRF-4,positive
R771 T1051 T1053 themeOf IRF-4,negative
R2739 T3439 T3438 equivalentTo ICSAT,IRF-4
R2740 T3440 T3438 equivalentTo M-17,IRF-4
R2741 T3442 T3427 themeOf IRF-4,RNA expression
R2742 T3443 T3428 themeOf β-actin,RNA expression
R2743 T3444 T3430 themeOf DNMT3A,expression
R2744 T3445 T3431 themeOf DNMT3B,expression
R2745 T3446 T3432 themeOf MeCP,expression
R2746 T3447 T3433 themeOf MBD1,expression
R2747 T3448 T3434 themeOf MBD2,expression
R2748 T3449 T3429 themeOf DNMT1,expression
R4761 T5682 T5681 partOf promoter,IRF-4
R5171 T6206 T6204 themeOf expression,absence
R5172 T6207 T6208 themeOf IRF-4,positive
R5173 T6209 T6210 themeOf IRF-4,negative
R5174 T6212 T6213 themeOf IRF-4,expression
R5175 T6213 T6211 themeOf expression,affect
R5798 T6977 T6978 themeOf IRF-4,expression
R5799 T6978 T6976 themeOf expression,Increase
R5800 T6979 T6980 themeOf IRF-4,expression
R5801 T6983 T6984 themeOf IRF-4,transcription
R5802 T6984 T6982 themeOf transcription,activation
R5803 T6985 T6986 themeOf IRF-4,transcription
R5804 T6986 T6987 themeOf transcription,induced
R5805 T6986 T6988 themeOf transcription,increased
R5807 T6992 T6993 themeOf IRF-4,positive
R5808 T6995 T6996 themeOf IRF-4,expression
R5809 T6996 T6994 themeOf expression,effect
R5810 T6998 T6999 themeOf IRF-4,mRNA level
R5811 T6999 T6997 themeOf mRNA level,increased
R5812 T7001 T7002 themeOf IRF-4,expression
R5813 T7002 T7000 themeOf expression,control
R8449 T10202 T10225 themeOf DNMT1,mRNA levels
R8450 T10202 T10228 themeOf DNMT1,expression
R8451 T10202 T10240 themeOf DNMT1,transcription
R8452 T10203 T10215 themeOf DNMT3A,mRNA expression
R8453 T10203 T10222 themeOf DNMT3A,mRNA levels
R8454 T10203 T10229 themeOf DNMT3A,expression
R8455 T10203 T10238 themeOf DNMT3A,transcription
R8456 T10204 T10214 themeOf DNMT3B,mRNA expression
R8457 T10204 T10223 themeOf DNMT3B,mRNA levels
R8458 T10204 T10232 themeOf DNMT3B,expression
R8459 T10204 T10239 themeOf DNMT3B,transcription
R8460 T10205 T10213 themeOf MBD1,mRNA expression
R8461 T10205 T10224 themeOf MBD1,mRNA levels
R8462 T10205 T10231 themeOf MBD1,expression
R8463 T10205 T10237 themeOf MBD1,transcription
R8464 T10206 T10210 themeOf MBD2,mRNA expression
R8465 T10206 T10221 themeOf MBD2,mRNA levels
R8466 T10206 T10230 themeOf MBD2,expression
R8467 T10206 T10241 themeOf MBD2,transcription
R8468 T10207 T10209 themeOf MBD4,mRNA expression
R8469 T10207 T10219 themeOf MBD4,mRNA levels
R8470 T10207 T10227 themeOf MBD4,expression
R8471 T10207 T10242 themeOf MBD4,transcription
R8472 T10208 T10211 themeOf MeCP,mRNA expression
R8473 T10208 T10220 themeOf MeCP,mRNA levels
R8474 T10208 T10226 themeOf MeCP,expression
R8475 T10208 T10243 themeOf MeCP,transcription
R8476 T10216 T10217 themeOf IRF-4,positive
R8477 T10216 T10218 themeOf IRF-4,negative
R8478 T10234 T10235 themeOf IRF-4,positive
R8479 T10234 T10236 themeOf IRF-4,negative
R9141 T11145 T11143 themeOf expression,lack
R9143 T11148 T11149 themeOf IRF-4,expression
R9144 T11149 T11147 themeOf expression,absent
R9145 T11150 T11151 themeOf IRF-4,positive
R9146 T11150 T11152 themeOf IRF-4,negative
R9147 T11153 T11154 themeOf IRF-4,negative
R9148 T11153 T11155 themeOf IRF-4,positive
R9149 T11157 T11156 themeOf transcription factor binding sites,change
R9150 T11157 T11148 partOf transcription factor binding sites,IRF-4
R9151 T11160 T11158 themeOf restriction sites,affect
R9152 T11160 T11148 partOf restriction sites,IRF-4
R9153 T11161 T11159 themeOf primer binding sites,affect
R9154 T11161 T11148 partOf primer binding sites,IRF-4
R9155 T11163 T11164 themeOf IRF-4,expression
R9156 T11164 T11165 themeOf expression,induced
R9157 T11166 T11165 causeOf IFN-α,induced
R9158 T11167 T11170 themeOf down-regulation,due
R9159 T11168 T11169 themeOf IRF-4,expression
R9160 T11168 T11171 themeOf IRF-4,re-expression
R9161 T11169 T11167 themeOf expression,down-regulation
R9162 T11171 T11172 themeOf re-expression,result
R9163 T11175 T11176 themeOf PU.1,interacting
R9164 T11177 T11176 themeOf IRF-4,interacting
R9165 T11179 T11180 themeOf IRF-4,expression
R9166 T11180 T11178 themeOf expression,regulation
R9167 T11181 T11182 themeOf IRF-4,expression
R9168 T11185 T11184 themeOf absence,account
R9169 T11186 T11187 themeOf IRF-4,expression
R9170 T11187 T11185 themeOf expression,absence
R9171 T11188 T11189 themeOf IRF-4,positive
R9172 T11192 T11191 themeOf regulation,role
R9173 T11193 T11194 themeOf IRF-4,expression
R9174 T11194 T11192 themeOf expression,regulation
R9175 T11195 T11196 causeOf NFκB elements,important role
R9176 T11195 T11204 partOf NFκB elements,IRF-4
R9177 T11195 T11202 themeOf NFκB elements,binding
R9178 T11197 T11198 themeOf IRF-4,induction
R9179 T11198 T11196 themeOf induction,important role
R9180 T11199 T11200 themeOf IRF-4,expression
R9181 T11200 T11201 themeOf expression,depends
R9182 T11202 T11201 causeOf binding,depends
R9183 T11203 T11202 themeOf c-Rel,binding
R9184 T11205 T11207 causeOf CpG,inhibits
R9185 T11205 T11204 partOf CpG,IRF-4
R9186 T11206 T11208 themeOf NFκB element,binding
R9187 T11206 T11204 partOf NFκB element,IRF-4
R9188 T11208 T11207 themeOf binding,inhibits
R9189 T11209 T11210 themeOf IRF-4,positive
R9190 T11209 T11211 themeOf IRF-4,negative
R9191 T11214 T11212 themeOf promoter,silencing
R9192 T11214 T11213 partOf promoter,IRF-4
R9193 T11215 T11216 themeOf IRF-4,deregulation
R9194 T11218 T11217 themeOf DNMT1,overexpression
R9195 T11219 T11220 themeOf DNMT1,expression
R9196 T11222 T11223 themeOf IRF-4,expression
R9197 T11224 T11225 themeOf IRF-4,expression
R9198 T11227 T11228 themeOf IRF-4,expression
R9199 T11228 T11226 themeOf expression,loss
R9200 T11229 T11233 themeOf expression,impaired
R9201 T11230 T11229 themeOf IFN consensus sequence binding protein,expression
R9202 T11230 T11235 themeOf IFN consensus sequence binding protein,loss
R9203 T11231 T11230 equivalentTo ICSBP,IFN consensus sequence binding protein
R9204 T11232 T11230 equivalentTo IRF-8,IFN consensus sequence binding protein
R9205 T11235 T11236 themeOf loss,reverted
R9206 T11237 T11238 themeOf ICSBP,negative
R9207 T11240 T11241 themeOf ICSBP,levels
R9208 T11241 T11239 themeOf levels,effect
R9209 T11242 T11243 themeOf ICSBP,positive
R9210 T11244 T11248 themeOf IRF-4,expression
R9211 T11248 T11249 themeOf expression,changes
R9212 T11254 T11253 equivalentTo IgH,immunoglobulin heavy-chain
R9213 T11257 T11256 themeOf overexpression,resulting
R9214 T11258 T11257 themeOf IRF-4,overexpression
R9215 T11259 T11260 themeOf IRF-4,expression
R9216 T11263 T11262 themeOf IRF-4,Down-regulation
R9217 T11264 T11267 themeOf IRF-4,knock-out
R9218 T11265 T11266 themeOf ICSBP,knock-out
R9219 T11268 T11269 themeOf IRF-4,up-regulation
R9220 T11272 T11273 themeOf IRF-4,expression
R9221 T11273 T11271 themeOf expression,regulates
R9222 T11274 T11276 themeOf expression,consequence
R9223 T11275 T11274 themeOf IRF-4,expression
R8446 T10199 T10200 themeOf promoter,regulation
R8447 T10199 T10201 partOf promoter,IRF-4
R8448 T10202 T10212 themeOf DNMT1,mRNA expression
R5159 T6184 T6187 themeOf Absence,due
R5160 T6185 T6186 themeOf IRF-4,expression
R5161 T6186 T6184 themeOf expression,Absence
R5162 T6189 T6190 themeOf IRF-4,expression
R5163 T6190 T6188 themeOf expression,lack
R5164 T6191 T6192 themeOf IRF-4,expression
R5165 T6193 T6194 themeOf bcr-abl,positive
R5166 T6195 T6196 themeOf bcr-abl,positve
R5167 T6197 T6198 themeOf bcr-abl,positve
R5168 T6199 T6200 themeOf bcr-abl,positive
R5169 T6201 T6202 themeOf bcr-abl,positive
R5170 T6205 T6206 themeOf IRF-4,expression
R4757 T5675 T5674 equivalentTo M.Sss I,CpG Methylase
R4758 T5678 T5677 themeOf luciferase,expressing
R4759 T5678 T5679 themeOf luciferase,expressed
R4760 T5682 T5683 themeOf promoter,activation
R2130 T2705 T2706 themeOf IRF-4,negative
R8035 T9679 T9678 themeOf promoter,decreased
R8036 T9679 T9677 partOf promoter,IRF-4
R8037 T9680 T9681 themeOf IRF-4,positive
R8038 T9682 T9683 themeOf IRF-4,positive
R8039 T9685 T9684 themeOf promoter,abrogation
R8040 T9685 T9686 partOf promoter,IRF-4
R8041 T9686 T9687 themeOf IRF-4,negative
R6491 T7818 T7819 themeOf IRF-4,expression
R6492 T7821 T7822 themeOf IRF-4,negative
R6493 T7823 T7824 themeOf IRF-4,positive
R6494 T7825 T7826 themeOf IRF-4,positive
R6495 T7827 T7828 themeOf IRF-4,transcription
R6496 T7829 T7830 themeOf IRF-4,negative
R9138 T11140 T11141 themeOf IRF-4,expression
R9139 T11141 T11139 themeOf expression,absent
R9140 T11144 T11145 themeOf IRF-4,expression
R9142 T11147 T11146 themeOf absent,responsible
R654 T84 T85 themeOf IRF-4,expression
R656 T88 T89 themeOf IRF-4,transcription
R657 T89 T87 themeOf transcription,influence
R658 T90 T91 themeOf IRF-4,negative
R659 T93 T92 themeOf increase,resulted
R37 T97 T98 themeOf IRF-4,positive
R38 T99 T100 themeOf IRF-4,down-regulation
R39 T103 T104 themeOf IRF-4,expression
R40 T104 T102 themeOf expression,down-regulated
R648 T72 T73 themeOf interferon regulatory factor 4,expression
R649 T73 T71 themeOf expression,Down-regulation
R650 T77 T76 themeOf interferon regulatory factor 4,deregulation
R651 T78 T77 equivalentTo IRF-4,interferon regulatory factor 4
R652 T81 T82 themeOf IRF-4,expression
R653 T82 T80 themeOf expression,regulation
R655 T85 T83 themeOf expression,altered
R660 T94 T93 themeOf IRF-4,increase
R661 T95 T96 themeOf IRF-4,negative
R747 T1005 T1004 themeOf expression,leading
R748 T1006 T1005 themeOf bcr-abl fusion gene,expression
R5806 T6989 T6990 themeOf IRF-4,transcripts
R7070 T8535 T8536 themeOf IRF-4,positive
R7071 T8538 T8539 themeOf IRF-4,negative
R7072 T8541 T8542 themeOf IRF-4,positive
R7073 T8543 T8544 themeOf IRF-4,negative
R7074 T8545 T8546 themeOf IRF-4,negative
R7075 T8547 T8548 themeOf IRF-4,positive
R7076 T8550 T8551 themeOf IRF-4,expression
R7077 T8551 T8549 themeOf expression,absence
R7078 T8552 T8553 themeOf IRF-4,positive
R7079 T8554 T8555 themeOf IRF-4,negative
R7080 T8557 T8558 themeOf IRF-4,expression
R7081 T8558 T8556 themeOf expression,regulation
R2736 T3435 T3424 themeOf IRF-4,transcriptional
R2737 T3436 T3425 themeOf MBD4,expression
R2738 T3437 T3426 themeOf IRF-4,expression

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T388 19-49 Q02556 denotes interferon regulatory factor 4
T389 19-49 Q14653 denotes interferon regulatory factor 4
T390 19-49 Q92985 denotes interferon regulatory factor 4
T391 19-49 Q15306 denotes interferon regulatory factor 4
T392 19-49 Q13568 denotes interferon regulatory factor 4
T393 169-172 P11274 denotes bcr
T394 173-176 P00519 denotes abl
T395 378-408 Q92985 denotes interferon regulatory factor 4
T396 378-408 Q13568 denotes interferon regulatory factor 4
T397 378-408 Q14653 denotes interferon regulatory factor 4
T398 378-408 Q15306 denotes interferon regulatory factor 4
T399 378-408 Q02556 denotes interferon regulatory factor 4
T400 410-415 Q15306 denotes IRF-4
T401 669-674 Q15306 denotes IRF-4
T402 745-750 Q15306 denotes IRF-4
T403 877-882 Q15306 denotes IRF-4
T404 922-927 Q15306 denotes IRF-4
T405 993-998 Q15306 denotes IRF-4
T406 1034-1039 Q15306 denotes IRF-4
T407 1205-1210 Q15306 denotes IRF-4
T408 1350-1355 Q15306 denotes IRF-4
T409 1376-1381 Q15306 denotes IRF-4
T410 1467-1472 Q15306 denotes IRF-4
T411 1596-1618 O95243 denotes DNA methyltransferases
T412 1596-1618 P26358 denotes DNA methyltransferases
T413 1596-1618 Q9UIS9 denotes DNA methyltransferases
T414 1596-1618 Q9Y6K1 denotes DNA methyltransferases
T415 1596-1618 Q9UBC3 denotes DNA methyltransferases
T416 1596-1618 Q9UBB5 denotes DNA methyltransferases
T417 1622-1649 P51608 denotes methyl-CpG-binding proteins
T418 1698-1703 Q15306 denotes IRF-4
T419 1767-1772 Q15306 denotes IRF-4
T1673 2199-2202 P11274 denotes bcr
T1674 2203-2206 P00519 denotes abl
T1675 2292-2297 P01562 denotes IFN-α
T1676 2473-2503 Q92985 denotes interferon regulatory factor 4
T1677 2473-2503 Q02556 denotes interferon regulatory factor 4
T1678 2473-2503 Q15306 denotes interferon regulatory factor 4
T1679 2473-2503 Q14653 denotes interferon regulatory factor 4
T1680 2473-2503 Q13568 denotes interferon regulatory factor 4
T1681 2505-2510 Q15306 denotes IRF-4
T1682 2554-2559 P01562 denotes IFN-α
T1683 2605-2610 Q15306 denotes IRF-4
T1684 2635-2664 Q14653 denotes Interferon regulatory factors
T1685 2635-2664 Q13568 denotes Interferon regulatory factors
T1686 2635-2664 Q92985 denotes Interferon regulatory factors
T1687 2635-2664 Q02556 denotes Interferon regulatory factors
T1688 2635-2664 Q15306 denotes Interferon regulatory factors
T1689 2938-2943 Q15306 denotes IRF-4
T1690 2945-2950 Q99419 denotes ICSAT
T1691 2951-2954 P12273 denotes Pip
T1692 2955-2959 Q15306 denotes MUM1
T1693 2955-2959 Q2TAK8 denotes MUM1
T1694 2960-2965 Q15306 denotes LSIRF
T1695 3071-3076 Q15306 denotes IRF-4
T1696 3135-3140 Q15306 denotes IRF-4
T1697 3367-3372 Q15306 denotes IRF-4
T1698 3480-3485 Q15306 denotes IRF-4
T1699 3571-3576 Q15306 denotes IRF-4
T1700 4167-4171 P16455 denotes MGMT
T1701 4173-4177 P53355 denotes DAPK
T1702 4179-4185 Q8N726 denotes p14ARF
T1703 4187-4195 P42772 denotes p15INK4b
T1704 4197-4205 P42771 denotes p16INK4a
T1705 4207-4212 Q3B891 denotes BRCA1
T1706 4214-4219 P55290 denotes CDH13
T1707 4224-4230 O14727 denotes APAF-1
T1708 4299-4304 P00519 denotes c-abl
T1709 4301-4304 P00519 denotes abl
T1710 4310-4313 P11274 denotes bcr
T1711 4376-4381 P00519 denotes c-abl
T1712 4378-4381 P00519 denotes abl
T1713 4493-4515 O95243 denotes DNA methyltransferases
T1714 4493-4515 Q9UIS9 denotes DNA methyltransferases
T1715 4493-4515 Q9Y6K1 denotes DNA methyltransferases
T1716 4493-4515 Q9UBC3 denotes DNA methyltransferases
T1717 4493-4515 Q9UBB5 denotes DNA methyltransferases
T1718 4493-4515 P26358 denotes DNA methyltransferases
T1719 4517-4522 P26358 denotes DNMTs
T1720 4609-4614 P26358 denotes DNMTs
T1721 4686-4713 P51608 denotes Methyl-CpG-binding proteins
T1722 4937-4942 Q15306 denotes IRF-4
T1723 5004-5009 Q15306 denotes IRF-4
T1724 5078-5083 Q15306 denotes IRF-4
T5865 12107-12112 Q15306 denotes IRF-4
T5866 12231-12244 P15840 denotes CpG Methylase
T5867 12414-12424 P08659 denotes luciferase
T5868 12592-12602 P08659 denotes luciferase
T5869 12779-12789 P08659 denotes luciferase
T5870 12854-12857 Q92934 denotes Bad
T5871 12877-12882 Q15306 denotes IRF-4
T5872 12967-12975 Q04864 denotes relative
T6450 13069-13074 Q15306 denotes IRF-4
T6451 13181-13186 Q15306 denotes IRF-4
T6452 13292-13297 Q15306 denotes IRF-4
T6453 13391-13394 P11274 denotes bcr
T6454 13395-13398 P00519 denotes abl
T6455 13430-13433 P11274 denotes bcr
T6456 13434-13437 P00519 denotes abl
T6457 13510-13513 P11274 denotes bcr
T6458 13514-13517 P00519 denotes abl
T6459 13563-13566 P11274 denotes bcr
T6460 13567-13570 P00519 denotes abl
T6461 13666-13669 P11274 denotes bcr
T6462 13670-13673 P00519 denotes abl
T6463 13740-13745 Q15306 denotes IRF-4
T6464 13793-13798 Q15306 denotes IRF-4
T6465 13964-13969 Q15306 denotes IRF-4
T6466 13994-13999 Q15306 denotes IRF-4
T6467 14307-14312 Q15306 denotes IRF-4
T7314 15945-15950 Q15306 denotes IRF-4
T8105 16035-16040 Q15306 denotes IRF-4
T8106 16146-16151 Q15306 denotes IRF-4
T8107 16539-16544 Q15306 denotes IRF-4
T8108 16828-16833 Q15306 denotes IRF-4
T8109 17018-17023 Q15306 denotes IRF-4
T8110 17145-17150 Q15306 denotes IRF-4
T8111 17357-17362 Q15306 denotes IRF-4
T8112 17513-17518 Q15306 denotes IRF-4
T9869 19781-19786 Q15306 denotes IRF-4
T9870 19905-19910 Q15306 denotes IRF-4
T9871 19968-19973 Q15306 denotes IRF-4
T9872 20204-20209 Q15306 denotes IRF-4
T9873 20264-20269 Q15306 denotes IRF-4
T9874 20374-20379 Q15306 denotes IRF-4
T9875 20473-20478 Q15306 denotes IRF-4
T9876 20598-20602 P48023 denotes FasL
T9877 20767-20772 Q15306 denotes IRF-4
T10411 20803-20825 Q9Y6K1 denotes DNA methyltransferases
T10412 20803-20825 Q9UIS9 denotes DNA methyltransferases
T10413 20803-20825 Q9UBC3 denotes DNA methyltransferases
T10414 20803-20825 Q9UBB5 denotes DNA methyltransferases
T10415 20803-20825 P26358 denotes DNA methyltransferases
T10416 20803-20825 O95243 denotes DNA methyltransferases
T10417 20830-20857 P51608 denotes methyl-CpG-binding proteins
T10418 20885-20890 Q15306 denotes IRF-4
T10419 20931-20935 P26358 denotes DNMT
T10420 21123-21128 Q15306 denotes IRF-4
T10421 21198-21202 P26358 denotes DNMT
T10422 21204-21209 P26358 denotes DNMT1
T10423 21211-21217 Q9Y6K1 denotes DNMT3A
T10424 21222-21228 Q9UBC3 denotes DNMT3B
T10425 21238-21242 Q9UIS9 denotes MBD1
T10426 21244-21248 Q9UBB5 denotes MBD2
T10427 21250-21254 O95243 denotes MBD4
T10428 21259-21263 P51608 denotes MeCP
T10429 21289-21294 Q15306 denotes IRF-4
T10430 21414-21418 P26358 denotes DNMT
T10431 21479-21484 Q15306 denotes IRF-4
T10432 21567-21572 Q15306 denotes IRF-4
T10433 21629-21633 P26358 denotes DNMT
T12446 21983-21988 Q15306 denotes IRF-4
T12447 22118-22123 Q15306 denotes IRF-4
T12448 22168-22173 Q15306 denotes IRF-4
T12449 22368-22373 Q15306 denotes IRF-4
T12450 22434-22439 Q15306 denotes IRF-4
T12451 22532-22537 Q15306 denotes IRF-4
T12452 22833-22838 Q15306 denotes IRF-4
T12453 22963-22968 Q15306 denotes IRF-4
T12454 23049-23054 P01562 denotes IFN-α
T12455 23213-23218 Q15306 denotes IRF-4
T12456 23453-23458 Q15306 denotes IRF-4
T12457 23579-23584 Q92985 denotes IRF-7
T12458 23598-23602 P17947 denotes PU.1
T12459 23635-23640 Q15306 denotes IRF-4
T12460 23709-23714 Q15306 denotes IRF-4
T12461 23859-23864 Q15306 denotes IRF-4
T12462 23958-23963 Q15306 denotes IRF-4
T12463 24083-24088 Q15306 denotes IRF-4
T12464 24313-24318 Q15306 denotes IRF-4
T12465 24351-24356 Q15306 denotes IRF-4
T12466 24419-24422 P08047 denotes SP1
T12467 24483-24488 Q15306 denotes IRF-4
T12468 24564-24569 Q15306 denotes IRF-4
T12469 24583-24588 Q15306 denotes IRF-4
T12470 24641-24646 Q04864 denotes c-Rel
T12471 24643-24646 Q04864 denotes Rel
T12472 24672-24677 Q15306 denotes IRF-4
T12473 24883-24888 Q15306 denotes IRF-4
T12474 25015-25020 Q15306 denotes IRF-4
T12475 25090-25095 Q15306 denotes IRF-4
T12476 25208-25213 P26358 denotes DNMTs
T12477 25310-25315 P26358 denotes DNMT1
T12478 25331-25335 P26358 denotes DNMT
T12479 25474-25479 P26358 denotes DNMTs
T12480 25541-25546 P26358 denotes DNMTs
T12481 25641-25646 P26358 denotes DNMT1
T12482 25689-25697 P42772 denotes p15INK4b
T12483 25813-25817 P26358 denotes DNMT
T12484 25892-25897 Q15306 denotes IRF-4
T12485 25957-25962 Q15306 denotes IRF-4
T12486 26093-26098 Q15306 denotes IRF-4
T12487 26342-26380 Q02556 denotes IFN consensus sequence binding protein
T12488 26382-26387 Q02556 denotes ICSBP
T12489 26388-26393 Q02556 denotes IRF-8
T12490 26475-26480 Q15306 denotes IRF-4
T12491 26528-26533 Q02556 denotes ICSBP
T12492 26650-26655 Q02556 denotes ICSBP
T12493 26666-26671 Q02556 denotes ICSBP
T12494 26776-26781 Q15306 denotes IRF-4
T12495 26838-26846 P42772 denotes p15INK4b
T12496 26848-26856 P42771 denotes p16INK4a
T12497 26860-26863 P04637 denotes p53
T12498 27082-27087 Q15306 denotes IRF-4
T12499 27144-27149 Q15306 denotes IRF-4
T12500 27192-27197 Q15306 denotes IRF-4
T12501 27345-27371 P01860 denotes immunoglobulin heavy-chain
T12502 27345-27371 P01871 denotes immunoglobulin heavy-chain
T12503 27345-27371 P01876 denotes immunoglobulin heavy-chain
T12504 27345-27371 P01877 denotes immunoglobulin heavy-chain
T12505 27345-27371 P01859 denotes immunoglobulin heavy-chain
T12506 27345-27371 P01857 denotes immunoglobulin heavy-chain
T12507 27345-27371 P01854 denotes immunoglobulin heavy-chain
T12508 27345-27371 P01861 denotes immunoglobulin heavy-chain
T12509 27345-27371 P01880 denotes immunoglobulin heavy-chain
T12510 27373-27376 P01876 denotes IgH
T12511 27373-27376 P01854 denotes IgH
T12512 27373-27376 P01857 denotes IgH
T12513 27373-27376 P01859 denotes IgH
T12514 27373-27376 P01860 denotes IgH
T12515 27373-27376 P01861 denotes IgH
T12516 27373-27376 P01871 denotes IgH
T12517 27373-27376 P01877 denotes IgH
T12518 27373-27376 P01880 denotes IgH
T12519 27382-27387 Q15306 denotes IRF-4
T12520 27432-27437 Q15306 denotes IRF-4
T12521 27469-27474 Q15306 denotes IRF-4
T12522 27730-27735 Q15306 denotes IRF-4
T12523 27756-27761 Q15306 denotes IRF-4
T12524 27850-27855 Q15306 denotes IRF-4
T12525 27859-27864 Q02556 denotes ICSBP
T12526 27902-27907 Q15306 denotes IRF-4
T12527 28015-28020 Q15306 denotes IRF-4
T12528 28052-28057 Q15306 denotes IRF-4
T12529 28102-28107 Q15306 denotes IRF-4
T12530 28161-28166 Q15306 denotes IRF-4
T7303 14338-14343 Q15306 denotes IRF-4
T7304 14498-14503 Q15306 denotes IRF-4
T7305 14548-14553 Q15306 denotes IRF-4
T7306 14939-14944 Q15306 denotes IRF-4
T7307 15048-15053 Q15306 denotes IRF-4
T7308 15255-15260 Q15306 denotes IRF-4
T7309 15465-15470 Q15306 denotes IRF-4
T7310 15533-15538 Q15306 denotes IRF-4
T7311 15613-15618 Q15306 denotes IRF-4
T7312 15726-15731 Q15306 denotes IRF-4
T7313 15836-15841 Q15306 denotes IRF-4
T9006 17562-17567 Q15306 denotes IRF-4
T9007 17672-17677 Q15306 denotes IRF-4
T9008 18302-18307 Q15306 denotes IRF-4
T9009 18324-18329 Q15306 denotes IRF-4
T9010 18367-18372 Q15306 denotes IRF-4
T9011 18393-18398 Q15306 denotes IRF-4
T9012 18466-18471 Q15306 denotes IRF-4
T9013 18486-18491 Q15306 denotes IRF-4
T9014 18548-18553 Q15306 denotes IRF-4
T9015 19096-19101 Q15306 denotes IRF-4
T9016 19210-19215 Q15306 denotes IRF-4
T9017 19426-19431 Q15306 denotes IRF-4
T9018 19501-19504 P08047 denotes SP1
T9019 19542-19547 Q15306 denotes IRF-4
T9020 19565-19570 Q15306 denotes IRF-4
T9021 19717-19722 Q15306 denotes IRF-4
T2773 5476-5481 Q15306 denotes IRF-4
T3190 5991-5996 Q15306 denotes IRF-4
T3191 6026-6031 Q15306 denotes IRF-4
T3787 6845-6850 Q15306 denotes IRF-4
T3788 7080-7085 Q15306 denotes IRF-4
T3789 7109-7116 P60709 denotes β-actin
T3790 7296-7300 P26358 denotes DNMT
T3791 7309-7314 P26358 denotes DNMT1
T3792 7315-7321 Q9Y6K1 denotes DNMT3A
T3793 7323-7329 Q9UBC3 denotes DNMT3B
T3794 7331-7335 P51608 denotes MeCP
T3795 7337-7341 Q9UIS9 denotes MBD1
T3796 7343-7347 Q9UBB5 denotes MBD2
T3797 7352-7356 O95243 denotes MBD4
T3798 7405-7410 Q15306 denotes IRF-4
T3799 8615-8620 Q15306 denotes IRF-4
T3800 8621-8626 Q99419 denotes ICSAT
T3801 8692-8699 P60709 denotes β-actin
T4624 9440-9445 Q15306 denotes IRF-4
T4625 9911-9915 P00519 denotes able
T5270 10700-10702 P0A7Z4 denotes pH
T5271 11328-11333 Q15306 denotes IRF-4

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T2703 5476-5481 Protein denotes IRF-4 true
T2704 5482-5490 Gene_expression denotes negative
T3049 5991-5996 Protein denotes IRF-4
T3050 6026-6031 Protein denotes IRF-4
T3389 6845-6850 Protein denotes IRF-4
T3390 6851-6866 Transcription denotes transcriptional
T3391 7052-7066 Transcription denotes RNA expression
T3392 7080-7085 Protein denotes IRF-4 true
T3393 7109-7116 Protein denotes β-actin true
T3394 7273-7283 Gene_expression denotes expression true
T3395 7309-7314 Protein denotes DNMT1 true
T3396 7315-7321 Protein denotes DNMT3A true
T3397 7323-7329 Protein denotes DNMT3B true
T3398 7331-7335 Protein denotes MeCP true
T3399 7337-7341 Protein denotes MBD1 true
T3400 7343-7347 Protein denotes MBD2
T3401 7352-7356 Protein denotes MBD4
T3402 7405-7410 Protein denotes IRF-4
T3403 7419-7429 Gene_expression denotes expression
T3404 8615-8620 Protein denotes IRF-4
T3405 8621-8626 Protein denotes ICSAT
T3406 8628-8632 Protein denotes M-17
T3407 8692-8699 Protein denotes β-actin
T4348 9440-9445 Protein denotes IRF-4
T4930 11328-11333 Protein denotes IRF-4
T5662 12107-12112 Protein denotes IRF-4
T35 0-15 Negative_regulation denotes Down-regulation
T36 19-49 Protein denotes interferon regulatory factor 4
T37 55-65 Gene_expression denotes expression true
T38 169-172 Protein denotes bcr true
T39 173-176 Protein denotes abl
T40 177-190 Localization denotes translocation
T41 378-408 Protein denotes interferon regulatory factor 4
T42 410-415 Protein denotes IRF-4
T43 669-674 Protein denotes IRF-4
T44 731-741 Regulation denotes regulation true
T45 745-750 Protein denotes IRF-4
T46 751-761 Gene_expression denotes expression
T47 869-876 Regulation denotes altered true
T48 877-882 Protein denotes IRF-4
T49 883-893 Gene_expression denotes expression
T50 922-927 Protein denotes IRF-4 true
T51 983-992 Regulation denotes influence
T52 993-998 Protein denotes IRF-4
T53 999-1012 Transcription denotes transcription
T54 1034-1039 Protein denotes IRF-4
T55 1040-1048 Gene_expression denotes negative
T56 1183-1192 Regulation denotes dependent
T57 1193-1201 Positive_regulation denotes increase
T58 1205-1210 Protein denotes IRF-4
T59 1350-1355 Protein denotes IRF-4
T60 1356-1364 Gene_expression denotes negative
T61 1376-1381 Protein denotes IRF-4
T62 1382-1390 Gene_expression denotes positive
T63 1467-1472 Protein denotes IRF-4
T64 1473-1488 Negative_regulation denotes down-regulation
T65 1537-1548 Binding denotes association
T66 1577-1581 Transcription denotes mRNA
T67 1698-1703 Protein denotes IRF-4
T68 1752-1766 Negative_regulation denotes down-regulated
T69 1767-1772 Protein denotes IRF-4
T70 1773-1783 Gene_expression denotes expression
T952 2172-2179 Positive_regulation denotes leading
T953 2183-2193 Gene_expression denotes expression
T954 2199-2218 Protein denotes bcr-abl fusion gene
T955 2278-2290 Protein denotes interferon α
T956 2292-2297 Protein denotes IFN-α
T957 2446-2454 Negative_regulation denotes impaired
T958 2455-2465 Gene_expression denotes expression
T959 2473-2503 Protein denotes interferon regulatory factor 4
T960 2505-2510 Protein denotes IRF-4 true
T961 2554-2559 Protein denotes IFN-α
T962 2592-2601 Negative_regulation denotes silencing
T963 2605-2610 Protein denotes IRF-4
T964 2938-2943 Protein denotes IRF-4
T965 2945-2950 Protein denotes ICSAT
T966 2951-2954 Protein denotes Pip
T967 2955-2959 Protein denotes MUM1
T968 2960-2965 Protein denotes LSIRF
T969 3002-3012 Gene_expression denotes expression
T970 3071-3076 Protein denotes IRF-4 true
T971 3077-3085 Gene_expression denotes positive
T972 3121-3131 Gene_expression denotes expression
T973 3135-3140 Protein denotes IRF-4
T974 3151-3158 Positive_regulation denotes induced
T975 3355-3363 Negative_regulation denotes deletion
T976 3367-3372 Protein denotes IRF-4
T977 3457-3465 Negative_regulation denotes impaired
T978 3466-3476 Gene_expression denotes expression
T979 3480-3485 Protein denotes IRF-4
T980 3571-3576 Protein denotes IRF-4
T981 4167-4171 Protein denotes MGMT
T982 4173-4177 Protein denotes DAPK
T983 4179-4185 Protein denotes p14ARF
T984 4187-4195 Protein denotes p15INK4b
T985 4197-4205 Protein denotes p16INK4a
T986 4207-4212 Protein denotes BRCA1
T987 4214-4219 Protein denotes CDH13
T988 4224-4230 Protein denotes APAF-1
T989 4272-4280 Regulation denotes regulate
T990 4281-4291 Gene_expression denotes expression
T991 4299-4304 Protein denotes c-abl
T992 4310-4313 Protein denotes bcr
T993 4376-4381 Protein denotes c-abl
T994 4736-4743 Negative_regulation denotes inhibit
T995 4748-4755 Binding denotes binding
T996 4923-4933 Regulation denotes mechanisms
T997 4937-4942 Protein denotes IRF-4
T998 4948-4958 Gene_expression denotes expression
T999 4959-4968 Negative_regulation denotes silencing
T1000 5004-5009 Protein denotes IRF-4
T1001 5078-5083 Protein denotes IRF-4
T1002 5084-5092 Gene_expression denotes positive
T1003 5098-5106 Gene_expression denotes negative
T5663 12231-12244 Protein denotes CpG Methylase
T5664 12246-12253 Protein denotes M.Sss I
T5665 12414-12424 Protein denotes luciferase
T5666 12569-12579 Gene_expression denotes expressing
T5667 12592-12602 Protein denotes luciferase
T5668 12627-12636 Gene_expression denotes expressed
T5669 12779-12789 Protein denotes luciferase
T5670 12877-12882 Protein denotes IRF-4
T5671 12892-12902 Positive_regulation denotes activation
T6152 13058-13065 Negative_regulation denotes Absence
T6153 13069-13074 Protein denotes IRF-4
T6154 13075-13085 Gene_expression denotes expression true
T6155 13111-13114 Positive_regulation denotes due
T6156 13173-13177 Negative_regulation denotes lack
T6157 13181-13186 Protein denotes IRF-4 true
T6158 13187-13197 Gene_expression denotes expression
T6159 13281-13288 Negative_regulation denotes absence
T6160 13292-13297 Protein denotes IRF-4
T6161 13298-13308 Gene_expression denotes expression
T6162 13391-13398 Protein denotes bcr-abl
T6163 13399-13407 Gene_expression denotes positive
T6164 13430-13437 Protein denotes bcr-abl
T6165 13438-13445 Gene_expression denotes positve
T6166 13510-13517 Protein denotes bcr-abl true
T6167 13518-13525 Gene_expression denotes positve true true
T6168 13563-13570 Protein denotes bcr-abl
T6169 13571-13579 Gene_expression denotes positive
T6170 13666-13673 Protein denotes bcr-abl
T6171 13674-13682 Gene_expression denotes positive
T6172 13740-13745 Protein denotes IRF-4
T6173 13782-13789 Negative_regulation denotes absence
T6174 13793-13798 Protein denotes IRF-4
T6175 13799-13809 Gene_expression denotes expression
T6176 13964-13969 Protein denotes IRF-4
T6177 13970-13978 Gene_expression denotes positive
T6178 13994-13999 Protein denotes IRF-4
T6179 14000-14008 Gene_expression denotes negative
T6180 14300-14306 Regulation denotes affect
T6181 14307-14312 Protein denotes IRF-4
T6182 14313-14323 Gene_expression denotes expression
T6942 14326-14334 Positive_regulation denotes Increase
T6943 14338-14343 Protein denotes IRF-4
T6944 14344-14354 Gene_expression denotes expression
T6945 14463-14474 Regulation denotes responsible
T6946 14479-14494 Negative_regulation denotes down-regulation
T6947 14498-14503 Protein denotes IRF-4
T6948 14504-14514 Gene_expression denotes expression
T6949 14548-14553 Protein denotes IRF-4
T6950 14925-14935 Positive_regulation denotes activation
T6951 14939-14944 Protein denotes IRF-4
T6952 14945-14958 Transcription denotes transcription true
T6953 15048-15053 Protein denotes IRF-4
T6954 15054-15067 Transcription denotes transcription
T6955 15072-15079 Positive_regulation denotes induced
T6956 15090-15099 Regulation denotes dependent true
T6957 15172-15181 Positive_regulation denotes increased
T6958 15255-15260 Protein denotes IRF-4
T6959 15261-15272 Transcription denotes transcripts
T6960 15452-15461 Positive_regulation denotes induction
T6961 15465-15470 Protein denotes IRF-4
T6962 15479-15489 Gene_expression denotes expression
T6963 15533-15538 Protein denotes IRF-4
T6964 15539-15547 Gene_expression denotes positive
T6965 15603-15609 Regulation denotes effect
T6966 15613-15618 Protein denotes IRF-4
T6967 15619-15629 Gene_expression denotes expression
T6968 15712-15721 Positive_regulation denotes increased
T6969 15726-15731 Protein denotes IRF-4
T6970 15732-15742 Transcription denotes mRNA level
T6971 15828-15835 Regulation denotes control
T6972 15836-15841 Protein denotes IRF-4
T6973 15842-15852 Gene_expression denotes expression
T6974 15892-15902 Positive_regulation denotes activation
T6975 15945-15950 Protein denotes IRF-4
T7803 16035-16040 Protein denotes IRF-4
T7804 16146-16151 Protein denotes IRF-4 true
T7805 16157-16167 Gene_expression denotes expression
T7806 16539-16544 Protein denotes IRF-4
T7807 16828-16833 Protein denotes IRF-4
T7808 16834-16842 Gene_expression denotes negative true
T7809 17018-17023 Protein denotes IRF-4
T7810 17024-17032 Gene_expression denotes positive
T7811 17145-17150 Protein denotes IRF-4
T7812 17151-17159 Gene_expression denotes positive
T7813 17357-17362 Protein denotes IRF-4
T7814 17363-17376 Transcription denotes transcription
T7815 17513-17518 Protein denotes IRF-4
T7816 17519-17527 Gene_expression denotes negative
T8505 17562-17567 Protein denotes IRF-4
T8506 17672-17677 Protein denotes IRF-4 true
T8507 18302-18307 Protein denotes IRF-4
T8508 18324-18329 Protein denotes IRF-4 true
T8509 18330-18338 Gene_expression denotes positive true
T8510 18367-18372 Protein denotes IRF-4
T8511 18393-18398 Protein denotes IRF-4
T8512 18399-18407 Gene_expression denotes negative
T8513 18466-18471 Protein denotes IRF-4
T8514 18486-18491 Protein denotes IRF-4 true
T8515 18492-18500 Gene_expression denotes positive true
T8516 18548-18553 Protein denotes IRF-4
T8517 18554-18562 Gene_expression denotes negative
T8518 19096-19101 Protein denotes IRF-4
T8519 19102-19110 Gene_expression denotes negative
T8520 19210-19215 Protein denotes IRF-4
T8521 19216-19224 Gene_expression denotes positive
T8522 19415-19422 Negative_regulation denotes absence
T8523 19426-19431 Protein denotes IRF-4
T8524 19432-19442 Gene_expression denotes expression
T8525 19542-19547 Protein denotes IRF-4
T8526 19548-19556 Gene_expression denotes positive
T8527 19565-19570 Protein denotes IRF-4
T8528 19571-19579 Gene_expression denotes negative
T8529 19703-19713 Regulation denotes regulation
T8530 19717-19722 Protein denotes IRF-4
T8531 19723-19733 Gene_expression denotes expression
T9660 19781-19786 Protein denotes IRF-4
T9661 19905-19910 Protein denotes IRF-4
T9662 19968-19973 Protein denotes IRF-4
T9663 20204-20209 Protein denotes IRF-4
T9664 20233-20242 Negative_regulation denotes decreased true
T9665 20264-20269 Protein denotes IRF-4
T9666 20270-20278 Gene_expression denotes positive
T9667 20374-20379 Protein denotes IRF-4
T9668 20380-20388 Gene_expression denotes positive
T9669 20473-20478 Protein denotes IRF-4
T9670 20479-20487 Gene_expression denotes negative
T9671 20598-20602 Protein denotes FasL
T9672 20715-20726 Binding denotes association
T9673 20767-20772 Protein denotes IRF-4
T11012 21983-21988 Protein denotes IRF-4
T11013 21989-21999 Gene_expression denotes expression
T11014 22118-22123 Protein denotes IRF-4
T11015 22160-22164 Negative_regulation denotes lack
T11016 22168-22173 Protein denotes IRF-4 true
T11017 22174-22184 Gene_expression denotes expression
T11018 22345-22356 Regulation denotes responsible
T11019 22368-22373 Protein denotes IRF-4
T11020 22374-22384 Gene_expression denotes expression true
T11021 22434-22439 Protein denotes IRF-4 true
T11022 22440-22448 Gene_expression denotes positive
T11023 22454-22462 Gene_expression denotes negative true
T11024 22532-22537 Protein denotes IRF-4 true
T11025 22538-22546 Gene_expression denotes negative true
T11026 22551-22559 Gene_expression denotes positive
T11027 22670-22690 Entity denotes factor binding sites
T11028 22754-22767 Entity denotes binding sites
T11029 22833-22838 Protein denotes IRF-4
T11030 22963-22968 Protein denotes IRF-4 true
T11031 22969-22979 Gene_expression denotes expression
T11032 23009-23016 Positive_regulation denotes induced true
T11033 23049-23054 Protein denotes IFN-α
T11034 23194-23209 Negative_regulation denotes down-regulation
T11035 23213-23218 Protein denotes IRF-4
T11036 23219-23229 Gene_expression denotes expression
T11037 23261-23264 Positive_regulation denotes due true
T11038 23339-23340 Gene_expression denotes -
T11039 23340-23350 Gene_expression denotes expression
T11040 23423-23438 Transcription denotes transcriptional
T11041 23453-23458 Protein denotes IRF-4 true
T11042 23579-23584 Protein denotes IRF-7
T11043 23598-23602 Protein denotes PU.1
T11044 23612-23623 Binding denotes interacting
T11045 23635-23640 Protein denotes IRF-4
T11046 23695-23705 Regulation denotes regulation
T11047 23709-23714 Protein denotes IRF-4
T11048 23715-23725 Gene_expression denotes expression
T11049 23859-23864 Protein denotes IRF-4
T11050 23865-23875 Gene_expression denotes expression
T11051 23958-23963 Protein denotes IRF-4
T11052 24072-24079 Negative_regulation denotes absence true
T11053 24083-24088 Protein denotes IRF-4
T11054 24089-24099 Gene_expression denotes expression true
T11055 24313-24318 Protein denotes IRF-4
T11056 24319-24327 Gene_expression denotes positive
T11057 24351-24356 Protein denotes IRF-4
T11058 24357-24365 Gene_expression denotes negative
T11059 24461-24465 Regulation denotes role
T11060 24469-24479 Regulation denotes regulation
T11061 24483-24488 Protein denotes IRF-4
T11062 24489-24499 Gene_expression denotes expression
T11063 24556-24560 Regulation denotes role
T11064 24564-24569 Protein denotes IRF-4 true
T11065 24570-24579 Positive_regulation denotes induction true
T11066 24583-24588 Protein denotes IRF-4 true
T11067 24589-24599 Gene_expression denotes expression
T11068 24611-24618 Binding denotes binding
T11069 24641-24646 Protein denotes c-Rel
T11070 24672-24677 Protein denotes IRF-4
T11071 24769-24776 Binding denotes binding
T11072 24883-24888 Protein denotes IRF-4
T11073 24889-24897 Gene_expression denotes positive
T11074 24903-24911 Gene_expression denotes negative
T11075 24998-25007 Negative_regulation denotes silencing true
T11076 25015-25020 Protein denotes IRF-4 true
T11077 25090-25095 Protein denotes IRF-4
T11078 25096-25108 Regulation denotes deregulation true
T11079 25292-25306 Positive_regulation denotes overexpression
T11080 25310-25315 Protein denotes DNMT1
T11081 25641-25646 Protein denotes DNMT1 true
T11082 25647-25657 Gene_expression denotes expression
T11083 25689-25697 Protein denotes p15INK4b
T11084 25892-25897 Protein denotes IRF-4
T11085 25898-25908 Gene_expression denotes expression
T11086 25957-25962 Protein denotes IRF-4
T11087 25963-25973 Gene_expression denotes expression
T11088 25977-25985 Negative_regulation denotes silenced
T11089 26085-26089 Negative_regulation denotes loss
T11090 26093-26098 Protein denotes IRF-4
T11091 26099-26109 Gene_expression denotes expression
T11092 26315-26325 Gene_expression denotes expression
T11093 26342-26380 Protein denotes IFN consensus sequence binding protein
T11094 26382-26387 Protein denotes ICSBP
T11095 26388-26393 Protein denotes IRF-8
T11096 26399-26407 Negative_regulation denotes impaired
T11097 26475-26480 Protein denotes IRF-4
T11098 26486-26490 Negative_regulation denotes loss
T11099 26516-26524 Negative_regulation denotes reverted
T11100 26528-26533 Protein denotes ICSBP
T11101 26534-26542 Gene_expression denotes negative
T11102 26640-26646 Regulation denotes effect
T11103 26650-26655 Protein denotes ICSBP
T11104 26666-26671 Protein denotes ICSBP
T11105 26672-26680 Gene_expression denotes positive
T11106 26776-26781 Protein denotes IRF-4
T11107 26838-26846 Protein denotes p15INK4b
T11108 26848-26856 Protein denotes p16INK4a
T11109 26860-26863 Protein denotes p53
T11110 27082-27087 Protein denotes IRF-4
T11111 27144-27149 Protein denotes IRF-4
T11112 27192-27197 Protein denotes IRF-4
T11113 27345-27371 Protein denotes immunoglobulin heavy-chain
T11114 27373-27376 Protein denotes IgH
T11115 27382-27387 Protein denotes IRF-4
T11116 27388-27397 Positive_regulation denotes resulting
T11117 27414-27428 Positive_regulation denotes overexpression
T11118 27432-27437 Protein denotes IRF-4
T11119 27469-27474 Protein denotes IRF-4
T11120 27475-27485 Gene_expression denotes expression
T11121 27730-27735 Protein denotes IRF-4
T11122 27737-27752 Negative_regulation denotes Down-regulation
T11123 27756-27761 Protein denotes IRF-4
T11124 27850-27855 Protein denotes IRF-4
T11125 27859-27864 Protein denotes ICSBP
T11126 27902-27907 Protein denotes IRF-4
T11127 27908-27921 Positive_regulation denotes up-regulation
T11128 28015-28020 Protein denotes IRF-4
T11129 28042-28051 Regulation denotes regulates
T11130 28052-28057 Protein denotes IRF-4
T11131 28058-28068 Gene_expression denotes expression
T11132 28088-28098 Gene_expression denotes expression
T11133 28102-28107 Protein denotes IRF-4
T11134 28161-28166 Protein denotes IRF-4
R19 T36 T37 themeOf interferon regulatory factor 4,expression
R20 T37 T35 themeOf expression,Down-regulation
R21 T38 T40 themeOf bcr,translocation
R22 T42 T41 equivalentTo IRF-4,interferon regulatory factor 4
R23 T45 T46 themeOf IRF-4,expression
R24 T46 T44 themeOf expression,regulation
R25 T48 T49 themeOf IRF-4,expression
R26 T49 T47 themeOf expression,altered
R27 T52 T53 themeOf IRF-4,transcription
R28 T53 T51 themeOf transcription,influence
R29 T54 T55 themeOf IRF-4,negative
R30 T57 T56 themeOf increase,dependent
R31 T58 T57 themeOf IRF-4,increase
R32 T59 T60 themeOf IRF-4,negative
R33 T61 T62 themeOf IRF-4,positive
R34 T63 T64 themeOf IRF-4,down-regulation
R35 T69 T70 themeOf IRF-4,expression
R36 T70 T68 themeOf expression,down-regulated
R720 T953 T952 themeOf expression,leading
R721 T954 T953 themeOf bcr-abl fusion gene,expression
R722 T956 T955 equivalentTo IFN-α,interferon α
R723 T958 T957 themeOf expression,impaired
R724 T959 T958 themeOf interferon regulatory factor 4,expression
R725 T960 T959 equivalentTo IRF-4,interferon regulatory factor 4
R726 T963 T962 themeOf IRF-4,silencing
R727 T964 T969 themeOf IRF-4,expression
R728 T965 T964 equivalentTo ICSAT,IRF-4
R729 T966 T964 equivalentTo Pip,IRF-4
R730 T967 T964 equivalentTo MUM1,IRF-4
R731 T968 T964 equivalentTo LSIRF,IRF-4
R732 T970 T971 themeOf IRF-4,positive
R733 T972 T974 themeOf expression,induced
R734 T973 T972 themeOf IRF-4,expression
R735 T976 T975 themeOf IRF-4,deletion
R736 T978 T977 themeOf expression,impaired
R737 T979 T978 themeOf IRF-4,expression
R738 T990 T989 themeOf expression,regulate
R739 T991 T990 themeOf c-abl,expression
R740 T992 T990 themeOf bcr,expression
R741 T995 T994 themeOf binding,inhibit
R742 T997 T998 themeOf IRF-4,expression
R743 T998 T996 themeOf expression,mechanisms
R744 T999 T996 causeOf silencing,mechanisms
R745 T1001 T1003 themeOf IRF-4,negative
R746 T1001 T1002 themeOf IRF-4,positive
R2129 T2703 T2704 themeOf IRF-4,negative
R2723 T3389 T3390 themeOf IRF-4,transcriptional
R2724 T3392 T3391 themeOf IRF-4,RNA expression
R2725 T3393 T3391 themeOf β-actin,RNA expression
R2726 T3395 T3394 themeOf DNMT1,expression
R2727 T3396 T3394 themeOf DNMT3A,expression
R2728 T3397 T3394 themeOf DNMT3B,expression
R2729 T3398 T3394 themeOf MeCP,expression
R2730 T3399 T3394 themeOf MBD1,expression
R2731 T3400 T3394 themeOf MBD2,expression
R2732 T3401 T3394 themeOf MBD4,expression
R2733 T3402 T3403 themeOf IRF-4,expression
R2734 T3405 T3404 equivalentTo ICSAT,IRF-4
R2735 T3406 T3404 equivalentTo M-17,IRF-4
R4754 T5664 T5663 equivalentTo M.Sss I,CpG Methylase
R4755 T5667 T5668 themeOf luciferase,expressed
R4756 T5667 T5666 themeOf luciferase,expressing
R5140 T6152 T6155 themeOf Absence,due
R5141 T6153 T6154 themeOf IRF-4,expression
R5142 T6154 T6152 themeOf expression,Absence
R5143 T6154 T6155 themeOf expression,due
R5144 T6157 T6158 themeOf IRF-4,expression
R5145 T6158 T6156 themeOf expression,lack
R5146 T6160 T6161 themeOf IRF-4,expression
R5147 T6161 T6159 themeOf expression,absence
R5148 T6162 T6163 themeOf bcr-abl,positive
R5149 T6164 T6165 themeOf bcr-abl,positve
R5150 T6166 T6167 themeOf bcr-abl,positve
R5151 T6168 T6169 themeOf bcr-abl,positive
R5152 T6170 T6171 themeOf bcr-abl,positive
R5153 T6174 T6175 themeOf IRF-4,expression
R5154 T6175 T6173 themeOf expression,absence
R5155 T6176 T6177 themeOf IRF-4,positive
R5156 T6178 T6179 themeOf IRF-4,negative
R5157 T6181 T6182 themeOf IRF-4,expression
R5158 T6182 T6180 themeOf expression,affect
R5774 T6943 T6944 themeOf IRF-4,expression
R5775 T6944 T6942 themeOf expression,Increase
R5776 T6946 T6945 themeOf down-regulation,responsible
R5777 T6947 T6948 themeOf IRF-4,expression
R5778 T6948 T6946 themeOf expression,down-regulation
R5779 T6951 T6952 themeOf IRF-4,transcription
R5780 T6952 T6950 themeOf transcription,activation
R5781 T6953 T6954 themeOf IRF-4,transcription
R5782 T6954 T6955 themeOf transcription,induced
R5783 T6954 T6957 themeOf transcription,increased
R5784 T6955 T6956 themeOf induced,dependent
R5785 T6955 T6957 themeOf induced,increased
R5786 T6958 T6959 themeOf IRF-4,transcripts
R5787 T6961 T6962 themeOf IRF-4,expression
R5788 T6962 T6960 themeOf expression,induction
R5789 T6963 T6964 themeOf IRF-4,positive
R5790 T6966 T6967 themeOf IRF-4,expression
R5791 T6967 T6965 themeOf expression,effect
R5792 T6969 T6968 themeOf IRF-4,increased
R5793 T6969 T6970 themeOf IRF-4,mRNA level
R5794 T6970 T6968 themeOf mRNA level,increased
R5795 T6972 T6973 themeOf IRF-4,expression
R5796 T6973 T6971 themeOf expression,control
R5797 T6975 T6974 causeOf IRF-4,activation
R6485 T7804 T7805 themeOf IRF-4,expression
R6486 T7807 T7808 themeOf IRF-4,negative
R6487 T7809 T7810 themeOf IRF-4,positive
R6488 T7811 T7812 themeOf IRF-4,positive
R6489 T7813 T7814 themeOf IRF-4,transcription
R6490 T7815 T7816 themeOf IRF-4,negative
R7058 T8508 T8509 themeOf IRF-4,positive
R7059 T8511 T8512 themeOf IRF-4,negative
R7060 T8514 T8515 themeOf IRF-4,positive
R7061 T8516 T8517 themeOf IRF-4,negative
R7062 T8518 T8519 themeOf IRF-4,negative
R7063 T8520 T8521 themeOf IRF-4,positive
R7064 T8523 T8524 themeOf IRF-4,expression
R7065 T8524 T8522 themeOf expression,absence
R7066 T8525 T8526 themeOf IRF-4,positive
R7067 T8527 T8528 themeOf IRF-4,negative
R7068 T8530 T8531 themeOf IRF-4,expression
R7069 T8531 T8529 themeOf expression,regulation
R8032 T9665 T9666 themeOf IRF-4,positive
R8033 T9667 T9668 themeOf IRF-4,positive
R8034 T9669 T9670 themeOf IRF-4,negative
R9075 T11012 T11013 themeOf IRF-4,expression
R9076 T11015 T11018 causeOf lack,responsible
R9077 T11016 T11017 themeOf IRF-4,expression
R9078 T11017 T11015 themeOf expression,lack
R9079 T11019 T11020 themeOf IRF-4,expression
R9080 T11020 T11018 themeOf expression,responsible
R9081 T11021 T11023 themeOf IRF-4,negative
R9082 T11021 T11022 themeOf IRF-4,positive
R9083 T11024 T11025 themeOf IRF-4,negative
R9084 T11024 T11026 themeOf IRF-4,positive
R9085 T11030 T11031 themeOf IRF-4,expression
R9086 T11031 T11032 themeOf expression,induced
R9087 T11033 T11032 causeOf IFN-α,induced
R9088 T11034 T11037 themeOf down-regulation,due
R9089 T11035 T11036 themeOf IRF-4,expression
R9090 T11036 T11034 themeOf expression,down-regulation
R9091 T11036 T11037 themeOf expression,due
R9092 T11041 T11040 themeOf IRF-4,transcriptional
R9093 T11042 T11044 themeOf IRF-7,interacting
R9094 T11043 T11044 themeOf PU.1,interacting
R9095 T11045 T11044 themeOf IRF-4,interacting
R9096 T11047 T11048 themeOf IRF-4,expression
R9097 T11048 T11046 themeOf expression,regulation
R9098 T11049 T11050 themeOf IRF-4,expression
R9099 T11053 T11054 themeOf IRF-4,expression
R9100 T11054 T11052 themeOf expression,absence
R9101 T11055 T11056 themeOf IRF-4,positive
R9102 T11057 T11058 themeOf IRF-4,negative
R9103 T11061 T11062 themeOf IRF-4,expression
R9104 T11062 T11060 themeOf expression,regulation
R9105 T11064 T11065 themeOf IRF-4,induction
R9106 T11065 T11063 themeOf induction,role
R9107 T11066 T11067 themeOf IRF-4,expression
R9108 T11069 T11068 themeOf c-Rel,binding
R9109 T11072 T11073 themeOf IRF-4,positive
R9110 T11072 T11074 themeOf IRF-4,negative
R9111 T11077 T11078 themeOf IRF-4,deregulation
R9112 T11080 T11079 themeOf DNMT1,overexpression
R9113 T11081 T11082 themeOf DNMT1,expression
R9114 T11084 T11085 themeOf IRF-4,expression
R9115 T11086 T11087 themeOf IRF-4,expression
R9116 T11087 T11088 themeOf expression,silenced
R9117 T11090 T11091 themeOf IRF-4,expression
R9118 T11091 T11089 themeOf expression,loss
R9119 T11092 T11096 themeOf expression,impaired
R9120 T11093 T11092 themeOf IFN consensus sequence binding protein,expression
R9121 T11094 T11093 equivalentTo ICSBP,IFN consensus sequence binding protein
R9122 T11095 T11093 equivalentTo IRF-8,IFN consensus sequence binding protein
R9123 T11098 T11099 themeOf loss,reverted
R9124 T11100 T11101 themeOf ICSBP,negative
R9125 T11101 T11099 causeOf negative,reverted
R9126 T11104 T11105 themeOf ICSBP,positive
R9127 T11114 T11113 equivalentTo IgH,immunoglobulin heavy-chain
R9128 T11117 T11116 themeOf overexpression,resulting
R9129 T11118 T11117 themeOf IRF-4,overexpression
R9130 T11119 T11120 themeOf IRF-4,expression
R9131 T11123 T11122 themeOf IRF-4,Down-regulation
R9132 T11124 T11127 themeOf IRF-4,up-regulation
R9133 T11125 T11127 themeOf ICSBP,up-regulation
R9134 T11126 T11127 themeOf IRF-4,up-regulation
R9135 T11130 T11131 themeOf IRF-4,expression
R9136 T11131 T11129 themeOf expression,regulates
R9137 T11133 T11132 themeOf IRF-4,expression