Id |
Subject |
Object |
Predicate |
Lexical cue |
T5280 |
0-13 |
JJ |
denotes |
Epidemiologic |
T5281 |
14-24 |
NN |
denotes |
assessment |
T5282 |
129-133 |
VBN |
denotes |
been |
T5283 |
25-27 |
IN |
denotes |
of |
T5284 |
28-31 |
DT |
denotes |
the |
T5285 |
32-43 |
NN |
denotes |
correlation |
T5286 |
44-51 |
IN |
denotes |
between |
T5287 |
52-53 |
DT |
denotes |
a |
T5288 |
65-74 |
NN |
denotes |
variation |
T5289 |
54-64 |
JJ |
denotes |
particular |
T5290 |
75-77 |
IN |
denotes |
in |
T5291 |
78-81 |
NN |
denotes |
DNA |
T5292 |
82-90 |
NN |
denotes |
sequence |
T5293 |
90-92 |
, |
denotes |
, |
T5294 |
92-94 |
CC |
denotes |
or |
T5295 |
95-107 |
NN |
denotes |
polymorphism |
T5296 |
107-109 |
, |
denotes |
, |
T5297 |
109-112 |
CC |
denotes |
and |
T5298 |
113-117 |
NN |
denotes |
risk |
T5299 |
118-121 |
IN |
denotes |
for |
T5300 |
122-124 |
NN |
denotes |
BC |
T5301 |
125-128 |
VBZ |
denotes |
has |
T5302 |
134-135 |
DT |
denotes |
a |
T5303 |
145-153 |
NN |
denotes |
paradigm |
T5304 |
136-144 |
JJ |
denotes |
dominant |
T5305 |
154-157 |
IN |
denotes |
for |
T5306 |
158-162 |
JJ |
denotes |
many |
T5307 |
163-168 |
NNS |
denotes |
years |
T5308 |
168-169 |
. |
denotes |
. |
T5309 |
169-227 |
sentence |
denotes |
Thus far, these efforts have met with scant success [26]. |
T5310 |
170-174 |
RB |
denotes |
Thus |
T5311 |
175-178 |
RB |
denotes |
far |
T5312 |
199-202 |
VBN |
denotes |
met |
T5313 |
178-180 |
, |
denotes |
, |
T5314 |
180-185 |
DT |
denotes |
these |
T5315 |
186-193 |
NNS |
denotes |
efforts |
T5316 |
194-198 |
VBP |
denotes |
have |
T5317 |
203-207 |
IN |
denotes |
with |
T5318 |
208-213 |
JJ |
denotes |
scant |
T5319 |
214-221 |
NN |
denotes |
success |
T5320 |
222-223 |
-LRB- |
denotes |
[ |
T5321 |
223-225 |
CD |
denotes |
26 |
T5322 |
225-226 |
-RRB- |
denotes |
] |
T5323 |
226-227 |
. |
denotes |
. |
T5324 |
227-368 |
sentence |
denotes |
A common limitation in design of such studies is that they involve assessment of a single polymorphism or occasionally, a few polymorphisms. |
T5325 |
228-229 |
DT |
denotes |
A |
T5326 |
237-247 |
NN |
denotes |
limitation |
T5327 |
230-236 |
JJ |
denotes |
common |
T5328 |
274-276 |
VBZ |
denotes |
is |
T5329 |
248-250 |
IN |
denotes |
in |
T5330 |
251-257 |
NN |
denotes |
design |
T5331 |
258-260 |
IN |
denotes |
of |
T5332 |
261-265 |
JJ |
denotes |
such |
T5333 |
266-273 |
NNS |
denotes |
studies |
T5334 |
277-281 |
IN |
denotes |
that |
T5335 |
287-294 |
VBP |
denotes |
involve |
T5336 |
282-286 |
PRP |
denotes |
they |
T5337 |
295-305 |
NN |
denotes |
assessment |
T5338 |
306-308 |
IN |
denotes |
of |
T5339 |
309-310 |
DT |
denotes |
a |
T5340 |
318-330 |
NN |
denotes |
polymorphism |
T5341 |
311-317 |
JJ |
denotes |
single |
T5342 |
331-333 |
CC |
denotes |
or |
T5343 |
334-346 |
RB |
denotes |
occasionally |
T5344 |
354-367 |
NNS |
denotes |
polymorphisms |
T5345 |
346-348 |
, |
denotes |
, |
T5346 |
348-349 |
DT |
denotes |
a |
T5347 |
350-353 |
JJ |
denotes |
few |
T5348 |
367-368 |
. |
denotes |
. |
T5349 |
368-646 |
sentence |
denotes |
Further, although the polymorphism assessed typically resides within a gene known to protect bronchial epithelium from carcinogens, oxidants, or DNA damage, the selection of the particular polymorphism for study is largely empiric, and not based on known functional properties. |
T5350 |
369-376 |
RB |
denotes |
Further |
T5351 |
581-583 |
VBZ |
denotes |
is |
T5352 |
376-378 |
, |
denotes |
, |
T5353 |
378-386 |
IN |
denotes |
although |
T5354 |
423-430 |
VBZ |
denotes |
resides |
T5355 |
387-390 |
DT |
denotes |
the |
T5356 |
391-403 |
NN |
denotes |
polymorphism |
T5357 |
404-412 |
VBN |
denotes |
assessed |
T5358 |
413-422 |
RB |
denotes |
typically |
T5359 |
431-437 |
IN |
denotes |
within |
T5360 |
438-439 |
DT |
denotes |
a |
T5361 |
440-444 |
NN |
denotes |
gene |
T5362 |
445-450 |
VBN |
denotes |
known |
T5363 |
451-453 |
TO |
denotes |
to |
T5364 |
454-461 |
VB |
denotes |
protect |
T5365 |
462-471 |
JJ |
denotes |
bronchial |
T5366 |
472-482 |
NN |
denotes |
epithelium |
T5367 |
483-487 |
IN |
denotes |
from |
T5368 |
488-499 |
NNS |
denotes |
carcinogens |
T5369 |
499-501 |
, |
denotes |
, |
T5370 |
501-509 |
NNS |
denotes |
oxidants |
T5371 |
509-511 |
, |
denotes |
, |
T5372 |
511-513 |
CC |
denotes |
or |
T5373 |
514-517 |
NN |
denotes |
DNA |
T5374 |
518-524 |
NN |
denotes |
damage |
T5375 |
524-526 |
, |
denotes |
, |
T5376 |
526-529 |
DT |
denotes |
the |
T5377 |
530-539 |
NN |
denotes |
selection |
T5378 |
540-542 |
IN |
denotes |
of |
T5379 |
543-546 |
DT |
denotes |
the |
T5380 |
558-570 |
NN |
denotes |
polymorphism |
T5381 |
547-557 |
JJ |
denotes |
particular |
T5382 |
571-574 |
IN |
denotes |
for |
T5383 |
575-580 |
NN |
denotes |
study |
T5384 |
584-591 |
RB |
denotes |
largely |
T5385 |
592-599 |
JJ |
denotes |
empiric |
T5386 |
599-601 |
, |
denotes |
, |
T5387 |
601-604 |
CC |
denotes |
and |
T5388 |
605-608 |
RB |
denotes |
not |
T5389 |
609-614 |
VBN |
denotes |
based |
T5390 |
615-617 |
IN |
denotes |
on |
T5391 |
618-623 |
JJ |
denotes |
known |
T5392 |
635-645 |
NNS |
denotes |
properties |
T5393 |
624-634 |
JJ |
denotes |
functional |
T5394 |
645-646 |
. |
denotes |
. |
T5395 |
646-914 |
sentence |
denotes |
These are problems because multiple infrequent polymorphisms at different sites may all contribute to risk and unless the key polymorphisms can be identified through a functional test, a statistically valid assessment would require much larger study populations [27]. |
T5396 |
647-652 |
DT |
denotes |
These |
T5397 |
653-656 |
VBP |
denotes |
are |
T5398 |
657-665 |
NNS |
denotes |
problems |
T5399 |
666-673 |
IN |
denotes |
because |
T5400 |
735-745 |
VB |
denotes |
contribute |
T5401 |
674-682 |
JJ |
denotes |
multiple |
T5402 |
694-707 |
NNS |
denotes |
polymorphisms |
T5403 |
683-693 |
JJ |
denotes |
infrequent |
T5404 |
708-710 |
IN |
denotes |
at |
T5405 |
711-720 |
JJ |
denotes |
different |
T5406 |
721-726 |
NNS |
denotes |
sites |
T5407 |
727-730 |
MD |
denotes |
may |
T5408 |
731-734 |
RB |
denotes |
all |
T5409 |
746-748 |
IN |
denotes |
to |
T5410 |
749-753 |
NN |
denotes |
risk |
T5411 |
754-757 |
CC |
denotes |
and |
T5412 |
758-764 |
IN |
denotes |
unless |
T5413 |
794-804 |
VBN |
denotes |
identified |
T5414 |
765-768 |
DT |
denotes |
the |
T5415 |
773-786 |
NNS |
denotes |
polymorphisms |
T5416 |
769-772 |
JJ |
denotes |
key |
T5417 |
787-790 |
MD |
denotes |
can |
T5418 |
791-793 |
VB |
denotes |
be |
T5419 |
871-878 |
VB |
denotes |
require |
T5420 |
805-812 |
IN |
denotes |
through |
T5421 |
813-814 |
DT |
denotes |
a |
T5422 |
826-830 |
NN |
denotes |
test |
T5423 |
815-825 |
JJ |
denotes |
functional |
T5424 |
830-832 |
, |
denotes |
, |
T5425 |
832-833 |
DT |
denotes |
a |
T5426 |
854-864 |
NN |
denotes |
assessment |
T5427 |
834-847 |
RB |
denotes |
statistically |
T5428 |
848-853 |
JJ |
denotes |
valid |
T5429 |
865-870 |
MD |
denotes |
would |
T5430 |
879-883 |
RB |
denotes |
much |
T5431 |
884-890 |
JJR |
denotes |
larger |
T5432 |
897-908 |
NNS |
denotes |
populations |
T5433 |
891-896 |
NN |
denotes |
study |
T5434 |
909-910 |
-LRB- |
denotes |
[ |
T5435 |
910-912 |
CD |
denotes |
27 |
T5436 |
912-913 |
-RRB- |
denotes |
] |
T5437 |
913-914 |
. |
denotes |
. |
R3240 |
T5281 |
T5282 |
nsubj |
assessment,been |
R3245 |
T5283 |
T5281 |
prep |
of,assessment |
R3253 |
T5284 |
T5285 |
det |
the,correlation |
R3257 |
T5285 |
T5283 |
pobj |
correlation,of |
R3261 |
T5286 |
T5285 |
prep |
between,correlation |
R3266 |
T5287 |
T5288 |
det |
a,variation |
R3270 |
T5288 |
T5286 |
pobj |
variation,between |
R3275 |
T5289 |
T5288 |
amod |
particular,variation |
R3278 |
T5290 |
T5288 |
prep |
in,variation |
R3281 |
T5291 |
T5292 |
compound |
DNA,sequence |
R3282 |
T5292 |
T5290 |
pobj |
sequence,in |
R3285 |
T5293 |
T5288 |
punct |
", ",variation |
R3291 |
T5294 |
T5288 |
cc |
or,variation |
R3295 |
T5295 |
T5288 |
conj |
polymorphism,variation |
R3299 |
T5296 |
T5288 |
punct |
", ",variation |
R3304 |
T5297 |
T5288 |
cc |
and,variation |
R3308 |
T5298 |
T5288 |
conj |
risk,variation |
R3313 |
T5299 |
T5298 |
prep |
for,risk |
R3317 |
T5300 |
T5299 |
pobj |
BC,for |
R3321 |
T5301 |
T5282 |
aux |
has,been |
R3323 |
T5302 |
T5303 |
det |
a,paradigm |
R3328 |
T5303 |
T5282 |
attr |
paradigm,been |
R3332 |
T5304 |
T5303 |
amod |
dominant,paradigm |
R3336 |
T5305 |
T5282 |
prep |
for,been |
R3343 |
T5306 |
T5307 |
amod |
many,years |
R3347 |
T5307 |
T5305 |
pobj |
years,for |
R3352 |
T5308 |
T5282 |
punct |
.,been |
R3356 |
T5310 |
T5311 |
advmod |
Thus,far |
R3363 |
T5280 |
T5281 |
amod |
Epidemiologic,assessment |
R3364 |
T5313 |
T5312 |
punct |
", ",met |
R3365 |
T5314 |
T5315 |
det |
these,efforts |
R3366 |
T5315 |
T5312 |
nsubj |
efforts,met |
R3367 |
T5387 |
T5385 |
cc |
and,empiric |
R3368 |
T5316 |
T5312 |
aux |
have,met |
R3369 |
T5388 |
T5387 |
neg |
not,and |
R3370 |
T5389 |
T5385 |
conj |
based,empiric |
R3371 |
T5317 |
T5312 |
prep |
with,met |
R3372 |
T5390 |
T5389 |
prep |
on,based |
R3373 |
T5391 |
T5392 |
amod |
known,properties |
R3374 |
T5318 |
T5319 |
amod |
scant,success |
R3375 |
T5392 |
T5390 |
pobj |
properties,on |
R3376 |
T5393 |
T5392 |
amod |
functional,properties |
R3377 |
T5394 |
T5351 |
punct |
.,is |
R3378 |
T5319 |
T5317 |
pobj |
success,with |
R3379 |
T5396 |
T5397 |
nsubj |
These,are |
R3380 |
T5320 |
T5321 |
punct |
[,26 |
R3381 |
T5398 |
T5397 |
attr |
problems,are |
R3382 |
T5399 |
T5400 |
mark |
because,contribute |
R3383 |
T5321 |
T5312 |
parataxis |
26,met |
R3384 |
T5400 |
T5397 |
advcl |
contribute,are |
R3385 |
T5322 |
T5321 |
punct |
],26 |
R3386 |
T5401 |
T5402 |
amod |
multiple,polymorphisms |
R3387 |
T5323 |
T5312 |
punct |
.,met |
R3388 |
T5402 |
T5400 |
nsubj |
polymorphisms,contribute |
R3389 |
T5403 |
T5402 |
amod |
infrequent,polymorphisms |
R3390 |
T5325 |
T5326 |
det |
A,limitation |
R3391 |
T5404 |
T5402 |
prep |
at,polymorphisms |
R3392 |
T5405 |
T5406 |
amod |
different,sites |
R3393 |
T5406 |
T5404 |
pobj |
sites,at |
R3394 |
T5407 |
T5400 |
aux |
may,contribute |
R3395 |
T5408 |
T5400 |
advmod |
all,contribute |
R3396 |
T5409 |
T5400 |
prep |
to,contribute |
R3397 |
T5410 |
T5409 |
pobj |
risk,to |
R3398 |
T5411 |
T5400 |
cc |
and,contribute |
R3399 |
T5326 |
T5328 |
nsubj |
limitation,is |
R3400 |
T5412 |
T5413 |
mark |
unless,identified |
R3401 |
T5413 |
T5419 |
advcl |
identified,require |
R3402 |
T5414 |
T5415 |
det |
the,polymorphisms |
R3403 |
T5327 |
T5326 |
amod |
common,limitation |
R3404 |
T5415 |
T5413 |
nsubjpass |
polymorphisms,identified |
R3405 |
T5329 |
T5326 |
prep |
in,limitation |
R3406 |
T5416 |
T5415 |
amod |
key,polymorphisms |
R3407 |
T5417 |
T5413 |
aux |
can,identified |
R3408 |
T5418 |
T5413 |
auxpass |
be,identified |
R3409 |
T5419 |
T5400 |
conj |
require,contribute |
R3410 |
T5420 |
T5413 |
prep |
through,identified |
R3411 |
T5330 |
T5329 |
pobj |
design,in |
R3412 |
T5421 |
T5422 |
det |
a,test |
R3413 |
T5422 |
T5420 |
pobj |
test,through |
R3414 |
T5423 |
T5422 |
amod |
functional,test |
R3415 |
T5331 |
T5330 |
prep |
of,design |
R3416 |
T5424 |
T5419 |
punct |
", ",require |
R3417 |
T5425 |
T5426 |
det |
a,assessment |
R3418 |
T5426 |
T5419 |
nsubj |
assessment,require |
R3419 |
T5332 |
T5333 |
amod |
such,studies |
R3420 |
T5427 |
T5428 |
advmod |
statistically,valid |
R3421 |
T5428 |
T5426 |
amod |
valid,assessment |
R3422 |
T5429 |
T5419 |
aux |
would,require |
R3423 |
T5333 |
T5331 |
pobj |
studies,of |
R3424 |
T5430 |
T5431 |
advmod |
much,larger |
R3425 |
T5431 |
T5432 |
amod |
larger,populations |
R3426 |
T5432 |
T5419 |
dobj |
populations,require |
R3427 |
T5433 |
T5432 |
compound |
study,populations |
R3428 |
T5334 |
T5335 |
mark |
that,involve |
R3429 |
T5434 |
T5435 |
punct |
[,27 |
R3430 |
T5435 |
T5397 |
parataxis |
27,are |
R3431 |
T5436 |
T5435 |
punct |
],27 |
R3432 |
T5335 |
T5328 |
ccomp |
involve,is |
R3433 |
T5437 |
T5397 |
punct |
.,are |
R3434 |
T5336 |
T5335 |
nsubj |
they,involve |
R3437 |
T5337 |
T5335 |
dobj |
assessment,involve |
R3441 |
T5338 |
T5337 |
prep |
of,assessment |
R3448 |
T5339 |
T5340 |
det |
a,polymorphism |
R3452 |
T5340 |
T5338 |
pobj |
polymorphism,of |
R3454 |
T5341 |
T5340 |
amod |
single,polymorphism |
R3455 |
T5342 |
T5340 |
cc |
or,polymorphism |
R3457 |
T5343 |
T5344 |
advmod |
occasionally,polymorphisms |
R3459 |
T5344 |
T5340 |
conj |
polymorphisms,polymorphism |
R3464 |
T5345 |
T5344 |
punct |
", ",polymorphisms |
R3468 |
T5346 |
T5344 |
det |
a,polymorphisms |
R3472 |
T5347 |
T5344 |
amod |
few,polymorphisms |
R3476 |
T5348 |
T5328 |
punct |
.,is |
R3479 |
T5350 |
T5351 |
advmod |
Further,is |
R3481 |
T5352 |
T5351 |
punct |
", ",is |
R3486 |
T5353 |
T5354 |
mark |
although,resides |
R3489 |
T5354 |
T5351 |
advcl |
resides,is |
R3494 |
T5355 |
T5356 |
det |
the,polymorphism |
R3501 |
T5356 |
T5354 |
nsubj |
polymorphism,resides |
R3504 |
T5357 |
T5356 |
acl |
assessed,polymorphism |
R3505 |
T5358 |
T5354 |
advmod |
typically,resides |
R3506 |
T5359 |
T5354 |
prep |
within,resides |
R3507 |
T5360 |
T5361 |
det |
a,gene |
R3510 |
T5361 |
T5359 |
pobj |
gene,within |
R3513 |
T5362 |
T5361 |
acl |
known,gene |
R3517 |
T5363 |
T5364 |
aux |
to,protect |
R3521 |
T5364 |
T5362 |
xcomp |
protect,known |
R3524 |
T5365 |
T5366 |
amod |
bronchial,epithelium |
R3529 |
T5366 |
T5364 |
dobj |
epithelium,protect |
R3532 |
T5367 |
T5364 |
prep |
from,protect |
R3537 |
T5368 |
T5367 |
pobj |
carcinogens,from |
R3541 |
T5369 |
T5368 |
punct |
", ",carcinogens |
R3544 |
T5370 |
T5368 |
conj |
oxidants,carcinogens |
R3547 |
T5371 |
T5370 |
punct |
", ",oxidants |
R3552 |
T5372 |
T5370 |
cc |
or,oxidants |
R3557 |
T5373 |
T5374 |
compound |
DNA,damage |
R3560 |
T5374 |
T5370 |
conj |
damage,oxidants |
R3564 |
T5375 |
T5351 |
punct |
", ",is |
R3567 |
T5376 |
T5377 |
det |
the,selection |
R3570 |
T5377 |
T5351 |
nsubj |
selection,is |
R3573 |
T5378 |
T5377 |
prep |
of,selection |
R3576 |
T5379 |
T5380 |
det |
the,polymorphism |
R3580 |
T5380 |
T5378 |
pobj |
polymorphism,of |
R3584 |
T5381 |
T5380 |
amod |
particular,polymorphism |
R3588 |
T5382 |
T5377 |
prep |
for,selection |
R3592 |
T5383 |
T5382 |
pobj |
study,for |
R3593 |
T5384 |
T5385 |
advmod |
largely,empiric |
R3597 |
T5385 |
T5351 |
acomp |
empiric,is |
R3603 |
T5386 |
T5385 |
punct |
", ",empiric |
R3361 |
T5311 |
T5312 |
advmod |
far,met |