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PMC:1310620 / 174-2442 JSONTXT

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Id Subject Object Predicate Lexical cue
T289 0-10 sentence denotes Background
T290 0-10 NN denotes Background
T291 10-207 sentence denotes Cigarette smoking is the primary cause of bronchogenic carcinoma (BC), yet only 10–15% of heavy smokers develop BC and it is likely that this variation in risk is, in part, genetically determined.
T292 11-20 NN denotes Cigarette
T293 21-28 NN denotes smoking
T294 29-31 VBZ denotes is
T295 32-35 DT denotes the
T296 44-49 NN denotes cause
T297 36-43 JJ denotes primary
T298 50-52 IN denotes of
T299 53-65 JJ denotes bronchogenic
T300 66-75 NN denotes carcinoma
T301 76-77 -LRB- denotes (
T302 77-79 NN denotes BC
T303 79-80 -RRB- denotes )
T304 80-82 , denotes ,
T305 82-85 CC denotes yet
T306 86-90 RB denotes only
T307 94-96 CD denotes 15
T308 91-93 CD denotes 10
T309 93-94 SYM denotes –
T310 96-97 NN denotes %
T311 115-122 VBP denotes develop
T312 98-100 IN denotes of
T313 101-106 JJ denotes heavy
T314 107-114 NNS denotes smokers
T315 123-125 NN denotes BC
T316 126-129 CC denotes and
T317 130-132 PRP denotes it
T318 133-135 VBZ denotes is
T319 136-142 JJ denotes likely
T320 143-147 IN denotes that
T321 196-206 VBN denotes determined
T322 148-152 DT denotes this
T323 153-162 NN denotes variation
T324 163-165 IN denotes in
T325 166-170 NN denotes risk
T326 171-173 VBZ denotes is
T327 173-175 , denotes ,
T328 175-177 IN denotes in
T329 178-182 JJ denotes part
T330 182-184 , denotes ,
T331 184-195 RB denotes genetically
T332 206-207 . denotes .
T333 207-392 sentence denotes We previously reported a set of antioxidant genes for which transcript abundance was lower in normal bronchial epithelial cells (NBEC) of BC individuals compared to non-BC individuals.
T334 208-210 PRP denotes We
T335 222-230 VBD denotes reported
T336 211-221 RB denotes previously
T337 231-232 DT denotes a
T338 233-236 NN denotes set
T339 237-239 IN denotes of
T340 240-251 NN denotes antioxidant
T341 252-257 NNS denotes genes
T342 258-261 IN denotes for
T343 289-292 VBD denotes was
T344 262-267 WDT denotes which
T345 268-278 NN denotes transcript
T346 279-288 NN denotes abundance
T347 293-298 JJR denotes lower
T348 299-301 IN denotes in
T349 302-308 JJ denotes normal
T350 330-335 NNS denotes cells
T351 309-318 JJ denotes bronchial
T352 319-329 JJ denotes epithelial
T353 336-337 -LRB- denotes (
T354 337-341 NN denotes NBEC
T355 341-342 -RRB- denotes )
T356 343-345 IN denotes of
T357 346-348 NN denotes BC
T358 349-360 NNS denotes individuals
T359 361-369 VBN denotes compared
T360 370-372 IN denotes to
T361 373-379 JJ denotes non-BC
T362 380-391 NNS denotes individuals
T363 391-392 . denotes .
T364 392-544 sentence denotes In unpublished studies of the same NBEC samples, transcript abundance values for several DNA repair genes were correlated with these antioxidant genes.
T365 393-395 IN denotes In
T366 504-514 VBN denotes correlated
T367 396-407 JJ denotes unpublished
T368 408-415 NNS denotes studies
T369 416-418 IN denotes of
T370 419-422 DT denotes the
T371 433-440 NNS denotes samples
T372 423-427 JJ denotes same
T373 428-432 NN denotes NBEC
T374 440-442 , denotes ,
T375 442-452 NN denotes transcript
T376 463-469 NNS denotes values
T377 453-462 NN denotes abundance
T378 470-473 IN denotes for
T379 474-481 JJ denotes several
T380 493-498 NNS denotes genes
T381 482-485 NN denotes DNA
T382 486-492 NN denotes repair
T383 499-503 VBD denotes were
T384 515-519 IN denotes with
T385 520-525 DT denotes these
T386 538-543 NNS denotes genes
T387 526-537 NN denotes antioxidant
T388 543-544 . denotes .
T389 544-843 sentence denotes From these data, we hypothesized that antioxidant and DNA repair genes are co-regulated by one or more transcription factors and that inter-individual variation in expression and/or function of one or more of these transcription factors is responsible for inter-individual variation in risk for BC.
T390 545-549 IN denotes From
T391 565-577 VBD denotes hypothesized
T392 550-555 DT denotes these
T393 556-560 NNS denotes data
T394 560-562 , denotes ,
T395 562-564 PRP denotes we
T396 578-582 IN denotes that
T397 620-632 VBN denotes co-regulated
T398 583-594 NN denotes antioxidant
T399 610-615 NNS denotes genes
T400 595-598 CC denotes and
T401 599-602 NN denotes DNA
T402 603-609 NN denotes repair
T403 616-619 VBP denotes are
T404 633-635 IN denotes by
T405 636-639 CD denotes one
T406 662-669 NNS denotes factors
T407 640-642 CC denotes or
T408 643-647 JJR denotes more
T409 648-661 NN denotes transcription
T410 670-673 CC denotes and
T411 674-678 IN denotes that
T412 782-784 VBZ denotes is
T413 679-695 JJ denotes inter-individual
T414 696-705 NN denotes variation
T415 706-708 IN denotes in
T416 709-719 NN denotes expression
T417 720-723 CC denotes and
T418 723-724 HYPH denotes /
T419 724-726 CC denotes or
T420 727-735 NN denotes function
T421 736-738 IN denotes of
T422 739-742 CD denotes one
T423 743-745 CC denotes or
T424 746-750 JJR denotes more
T425 751-753 IN denotes of
T426 754-759 DT denotes these
T427 774-781 NNS denotes factors
T428 760-773 NN denotes transcription
T429 785-796 JJ denotes responsible
T430 797-800 IN denotes for
T431 801-817 JJ denotes inter-individual
T432 818-827 NN denotes variation
T433 828-830 IN denotes in
T434 831-835 NN denotes risk
T435 836-839 IN denotes for
T436 840-842 NN denotes BC
T437 842-843 . denotes .
T438 843-852 sentence denotes Methods
T439 845-852 NNS denotes Methods
T440 852-1000 sentence denotes The putative transcription factor recognition sites common to six of the antioxidant genes were identified through in silico DNA sequence analysis.
T441 853-856 DT denotes The
T442 899-904 NNS denotes sites
T443 857-865 JJ denotes putative
T444 866-879 NN denotes transcription
T445 880-886 NN denotes factor
T446 887-898 NN denotes recognition
T447 949-959 VBN denotes identified
T448 905-911 JJ denotes common
T449 912-914 IN denotes to
T450 915-918 CD denotes six
T451 919-921 IN denotes of
T452 922-925 DT denotes the
T453 938-943 NNS denotes genes
T454 926-937 NN denotes antioxidant
T455 944-948 VBD denotes were
T456 960-967 IN denotes through
T457 968-970 FW denotes in
T458 971-977 FW denotes silico
T459 991-999 NN denotes analysis
T460 978-981 NN denotes DNA
T461 982-990 NN denotes sequence
T462 999-1000 . denotes .
T463 1000-1231 sentence denotes The transcript abundance values of these transcription factors (n = 6) and an expanded group of antioxidant and DNA repair genes (n = 16) were measured simultaneously by quantitative PCR in NBEC of 24 non-BC and 25 BC individuals.
T464 1001-1004 DT denotes The
T465 1026-1032 NNS denotes values
T466 1005-1015 NN denotes transcript
T467 1016-1025 NN denotes abundance
T468 1144-1152 VBN denotes measured
T469 1033-1035 IN denotes of
T470 1036-1041 DT denotes these
T471 1056-1063 NNS denotes factors
T472 1042-1055 NN denotes transcription
T473 1064-1065 -LRB- denotes (
T474 1069-1070 CD denotes 6
T475 1065-1066 NN denotes n
T476 1067-1068 SYM denotes =
T477 1070-1071 -RRB- denotes )
T478 1072-1075 CC denotes and
T479 1076-1078 DT denotes an
T480 1088-1093 NN denotes group
T481 1079-1087 VBN denotes expanded
T482 1094-1096 IN denotes of
T483 1097-1108 NN denotes antioxidant
T484 1124-1129 NNS denotes genes
T485 1109-1112 CC denotes and
T486 1113-1116 NN denotes DNA
T487 1117-1123 NN denotes repair
T488 1130-1131 -LRB- denotes (
T489 1135-1137 CD denotes 16
T490 1131-1132 NN denotes n
T491 1133-1134 SYM denotes =
T492 1137-1138 -RRB- denotes )
T493 1139-1143 VBD denotes were
T494 1153-1167 RB denotes simultaneously
T495 1168-1170 IN denotes by
T496 1171-1183 JJ denotes quantitative
T497 1184-1187 NN denotes PCR
T498 1188-1190 IN denotes in
T499 1191-1195 NN denotes NBEC
T500 1196-1198 IN denotes of
T501 1199-1201 CD denotes 24
T502 1202-1208 JJ denotes non-BC
T503 1209-1212 CC denotes and
T504 1213-1215 CD denotes 25
T505 1216-1218 NN denotes BC
T506 1219-1230 NNS denotes individuals
T507 1230-1231 . denotes .
T508 1231-1240 sentence denotes Results
T509 1233-1240 NNS denotes Results
T510 1240-1406 sentence denotes CEBPG transcription factor was significantly (p < 0.01) correlated with eight of the antioxidant or DNA repair genes in non-BC individuals but not in BC individuals.
T511 1241-1246 NN denotes CEBPG
T512 1261-1267 NN denotes factor
T513 1247-1260 NN denotes transcription
T514 1297-1307 VBN denotes correlated
T515 1268-1271 VBD denotes was
T516 1272-1285 RB denotes significantly
T517 1286-1287 -LRB- denotes (
T518 1291-1295 CD denotes 0.01
T519 1287-1288 NN denotes p
T520 1289-1290 SYM denotes <
T521 1295-1296 -RRB- denotes )
T522 1308-1312 IN denotes with
T523 1313-1318 CD denotes eight
T524 1319-1321 IN denotes of
T525 1322-1325 DT denotes the
T526 1352-1357 NNS denotes genes
T527 1326-1337 NN denotes antioxidant
T528 1338-1340 CC denotes or
T529 1341-1344 NN denotes DNA
T530 1345-1351 NN denotes repair
T531 1358-1360 IN denotes in
T532 1361-1367 JJ denotes non-BC
T533 1368-1379 NNS denotes individuals
T534 1380-1383 CC denotes but
T535 1384-1387 RB denotes not
T536 1388-1390 IN denotes in
T537 1391-1393 NN denotes BC
T538 1394-1405 NNS denotes individuals
T539 1405-1406 . denotes .
T540 1406-1624 sentence denotes In BC individuals the correlation with CEBPG was significantly (p < 0.01) lower than that of non-BC individuals for four of the genes (XRCC1, ERCC5, GSTP1, and SOD1) and the difference was nearly significant for GPX1.
T541 1407-1409 IN denotes In
T542 1452-1455 VBD denotes was
T543 1410-1412 NN denotes BC
T544 1413-1424 NNS denotes individuals
T545 1425-1428 DT denotes the
T546 1429-1440 NN denotes correlation
T547 1441-1445 IN denotes with
T548 1446-1451 NN denotes CEBPG
T549 1456-1469 RB denotes significantly
T550 1481-1486 JJR denotes lower
T551 1470-1471 -LRB- denotes (
T552 1475-1479 CD denotes 0.01
T553 1471-1472 NN denotes p
T554 1473-1474 SYM denotes <
T555 1479-1480 -RRB- denotes )
T556 1487-1491 IN denotes than
T557 1492-1496 DT denotes that
T558 1497-1499 IN denotes of
T559 1500-1506 JJ denotes non-BC
T560 1507-1518 NNS denotes individuals
T561 1519-1522 IN denotes for
T562 1523-1527 CD denotes four
T563 1528-1530 IN denotes of
T564 1531-1534 DT denotes the
T565 1535-1540 NNS denotes genes
T566 1541-1542 -LRB- denotes (
T567 1542-1547 NN denotes XRCC1
T568 1547-1549 , denotes ,
T569 1549-1554 NN denotes ERCC5
T570 1554-1556 , denotes ,
T571 1556-1561 NN denotes GSTP1
T572 1561-1563 , denotes ,
T573 1563-1566 CC denotes and
T574 1567-1571 NN denotes SOD1
T575 1571-1572 -RRB- denotes )
T576 1573-1576 CC denotes and
T577 1577-1580 DT denotes the
T578 1581-1591 NN denotes difference
T579 1592-1595 VBD denotes was
T580 1596-1602 RB denotes nearly
T581 1603-1614 JJ denotes significant
T582 1615-1618 IN denotes for
T583 1619-1623 NN denotes GPX1
T584 1623-1624 . denotes .
T585 1624-1739 sentence denotes The only other transcription factor correlated with any of these five target genes in non-BC individuals was E2F1.
T586 1625-1628 DT denotes The
T587 1654-1660 NN denotes factor
T588 1629-1633 JJ denotes only
T589 1634-1639 JJ denotes other
T590 1640-1653 NN denotes transcription
T591 1730-1733 VBD denotes was
T592 1661-1671 VBN denotes correlated
T593 1672-1676 IN denotes with
T594 1677-1680 DT denotes any
T595 1681-1683 IN denotes of
T596 1684-1689 DT denotes these
T597 1702-1707 NNS denotes genes
T598 1690-1694 CD denotes five
T599 1695-1701 NN denotes target
T600 1708-1710 IN denotes in
T601 1711-1717 JJ denotes non-BC
T602 1718-1729 NNS denotes individuals
T603 1734-1738 NN denotes E2F1
T604 1738-1739 . denotes .
T605 1739-1928 sentence denotes E2F1 was correlated with GSTP1 among non-BC individuals, but in contrast to CEBPG, there was no significant difference in this correlation in non-BC individuals compared to BC individuals.
T606 1740-1744 NN denotes E2F1
T607 1749-1759 VBN denotes correlated
T608 1745-1748 VBD denotes was
T609 1760-1764 IN denotes with
T610 1765-1770 NN denotes GSTP1
T611 1771-1776 IN denotes among
T612 1777-1783 JJ denotes non-BC
T613 1784-1795 NNS denotes individuals
T614 1795-1797 , denotes ,
T615 1797-1800 CC denotes but
T616 1801-1803 IN denotes in
T617 1829-1832 VBD denotes was
T618 1804-1812 NN denotes contrast
T619 1813-1815 IN denotes to
T620 1816-1821 NN denotes CEBPG
T621 1821-1823 , denotes ,
T622 1823-1828 EX denotes there
T623 1833-1835 DT denotes no
T624 1848-1858 NN denotes difference
T625 1836-1847 JJ denotes significant
T626 1859-1861 IN denotes in
T627 1862-1866 DT denotes this
T628 1867-1878 NN denotes correlation
T629 1879-1881 IN denotes in
T630 1882-1888 JJ denotes non-BC
T631 1889-1900 NNS denotes individuals
T632 1901-1909 VBN denotes compared
T633 1910-1912 IN denotes to
T634 1913-1915 NN denotes BC
T635 1916-1927 NNS denotes individuals
T636 1927-1928 . denotes .
T637 1928-1940 sentence denotes Conclusion
T638 1930-1940 NN denotes Conclusion
T639 1940-2105 sentence denotes We conclude that CEBPG is the transcription factor primarily responsible for regulating transcription of key antioxidant and DNA repair genes in non-BC individuals.
T640 1941-1943 PRP denotes We
T641 1944-1952 VBP denotes conclude
T642 1953-1957 IN denotes that
T643 1964-1966 VBZ denotes is
T644 1958-1963 NN denotes CEBPG
T645 1967-1970 DT denotes the
T646 1985-1991 NN denotes factor
T647 1971-1984 NN denotes transcription
T648 1992-2001 RB denotes primarily
T649 2002-2013 JJ denotes responsible
T650 2014-2017 IN denotes for
T651 2018-2028 VBG denotes regulating
T652 2029-2042 NN denotes transcription
T653 2043-2045 IN denotes of
T654 2046-2049 JJ denotes key
T655 2077-2082 NNS denotes genes
T656 2050-2061 NN denotes antioxidant
T657 2062-2065 CC denotes and
T658 2066-2069 NN denotes DNA
T659 2070-2076 NN denotes repair
T660 2083-2085 IN denotes in
T661 2086-2092 JJ denotes non-BC
T662 2093-2104 NNS denotes individuals
T663 2104-2105 . denotes .
T664 2105-2268 sentence denotes Further, we conclude that the heavy smokers selected for development of BC are those who have sub-optimal regulation of antioxidant and DNA repair genes by CEBPG.
T665 2106-2113 RB denotes Further
T666 2118-2126 VBP denotes conclude
T667 2113-2115 , denotes ,
T668 2115-2117 PRP denotes we
T669 2127-2131 IN denotes that
T670 2181-2184 VBP denotes are
T671 2132-2135 DT denotes the
T672 2142-2149 NNS denotes smokers
T673 2136-2141 JJ denotes heavy
T674 2150-2158 VBN denotes selected
T675 2159-2162 IN denotes for
T676 2163-2174 NN denotes development
T677 2175-2177 IN denotes of
T678 2178-2180 NN denotes BC
T679 2185-2190 DT denotes those
T680 2191-2194 WP denotes who
T681 2195-2199 VBP denotes have
T682 2200-2211 JJ denotes sub-optimal
T683 2212-2222 NN denotes regulation
T684 2223-2225 IN denotes of
T685 2226-2237 NN denotes antioxidant
T686 2253-2258 NNS denotes genes
T687 2238-2241 CC denotes and
T688 2242-2245 NN denotes DNA
T689 2246-2252 NN denotes repair
T690 2259-2261 IN denotes by
T691 2262-2267 NN denotes CEBPG
T692 2267-2268 . denotes .
R94 T370 T371 det the,samples
R95 T371 T369 pobj samples,of
R21 T292 T293 compound Cigarette,smoking
R22 T293 T294 nsubj smoking,is
R23 T295 T296 det the,cause
R24 T296 T294 attr cause,is
R26 T298 T296 prep of,cause
R27 T299 T300 amod bronchogenic,carcinoma
R28 T300 T298 pobj carcinoma,of
R29 T301 T300 punct (,carcinoma
R30 T302 T300 appos BC,carcinoma
R31 T303 T294 punct ),is
R32 T304 T294 punct ", ",is
R33 T305 T294 cc yet,is
R34 T306 T307 advmod only,15
R35 T307 T310 nummod 15,%
R38 T310 T311 nsubj %,develop
R39 T311 T294 conj develop,is
R43 T315 T311 dobj BC,develop
R44 T316 T311 cc and,develop
R45 T317 T318 nsubj it,is
R46 T318 T311 conj is,develop
R47 T319 T318 acomp likely,is
R48 T320 T321 mark that,determined
R49 T321 T318 ccomp determined,is
R60 T332 T311 punct .,develop
R61 T334 T335 nsubj We,reported
R62 T336 T335 advmod previously,reported
R63 T337 T338 det a,set
R64 T338 T335 dobj set,reported
R65 T339 T338 prep of,set
R66 T340 T341 compound antioxidant,genes
R67 T341 T339 pobj genes,of
R68 T342 T343 prep for,was
R69 T343 T341 relcl was,genes
R73 T347 T343 acomp lower,was
R74 T348 T343 prep in,was
R75 T349 T350 amod normal,cells
R76 T350 T348 pobj cells,in
R79 T353 T350 punct (,cells
R80 T354 T350 appos NBEC,cells
R81 T355 T350 punct ),cells
R82 T356 T350 prep of,cells
R83 T357 T358 compound BC,individuals
R84 T358 T356 pobj individuals,of
R85 T359 T343 prep compared,was
R86 T360 T359 prep to,compared
R87 T361 T362 amod non-BC,individuals
R88 T362 T360 pobj individuals,to
R89 T363 T335 punct .,reported
R90 T365 T366 prep In,correlated
R91 T367 T368 amod unpublished,studies
R92 T368 T365 pobj studies,In
R93 T369 T368 prep of,studies
R98 T374 T366 punct ", ",correlated
R99 T375 T376 compound transcript,values
R100 T376 T366 nsubjpass values,correlated
R102 T378 T376 prep for,values
R103 T379 T380 amod several,genes
R104 T380 T378 pobj genes,for
R107 T383 T366 auxpass were,correlated
R108 T384 T366 prep with,correlated
R109 T385 T386 det these,genes
R110 T386 T384 pobj genes,with
R112 T388 T366 punct .,correlated
R113 T390 T391 prep From,hypothesized
R114 T392 T393 det these,data
R115 T393 T390 pobj data,From
R116 T394 T391 punct ", ",hypothesized
R117 T395 T391 nsubj we,hypothesized
R118 T396 T397 mark that,co-regulated
R119 T397 T391 advcl co-regulated,hypothesized
R121 T399 T397 nsubjpass genes,co-regulated
R122 T400 T398 cc and,antioxidant
R123 T401 T402 compound DNA,repair
R124 T402 T398 conj repair,antioxidant
R126 T404 T397 agent by,co-regulated
R127 T405 T406 nummod one,factors
R128 T406 T404 pobj factors,by
R132 T410 T397 cc and,co-regulated
R133 T411 T412 mark that,is
R134 T412 T397 conj is,co-regulated
R149 T427 T425 pobj factors,of
R150 T428 T427 compound transcription,factors
R151 T429 T412 acomp responsible,is
R152 T430 T429 prep for,responsible
R153 T431 T432 amod inter-individual,variation
R154 T432 T430 pobj variation,for
R155 T433 T432 prep in,variation
R156 T434 T433 pobj risk,in
R157 T435 T434 prep for,risk
R158 T436 T435 pobj BC,for
R159 T437 T391 punct .,hypothesized
R160 T441 T442 det The,sites
R161 T442 T447 nsubjpass sites,identified
R166 T448 T442 amod common,sites
R167 T449 T448 prep to,common
R168 T450 T449 pobj six,to
R169 T451 T450 prep of,six
R170 T452 T453 det the,genes
R171 T453 T451 pobj genes,of
R173 T455 T447 auxpass were,identified
R174 T456 T447 prep through,identified
R175 T457 T458 advmod in,silico
R176 T458 T459 amod silico,analysis
R177 T459 T456 pobj analysis,through
R180 T462 T447 punct .,identified
R181 T464 T465 det The,values
R182 T465 T468 nsubjpass values,measured
R185 T469 T465 prep of,values
R186 T470 T471 det these,factors
R187 T471 T469 pobj factors,of
R189 T473 T474 punct (,6
R190 T474 T465 parataxis 6,values
R193 T477 T474 punct ),6
R194 T478 T465 cc and,values
R195 T479 T480 det an,group
R196 T480 T465 conj group,values
R198 T482 T480 prep of,group
R199 T483 T484 nmod antioxidant,genes
R200 T484 T482 pobj genes,of
R204 T488 T489 punct (,16
R205 T489 T480 parataxis 16,group
R208 T492 T489 punct ),16
R209 T493 T468 auxpass were,measured
R210 T494 T468 advmod simultaneously,measured
R211 T495 T468 prep by,measured
R212 T496 T497 amod quantitative,PCR
R213 T497 T495 pobj PCR,by
R214 T498 T468 prep in,measured
R215 T499 T498 pobj NBEC,in
R216 T500 T499 prep of,NBEC
R217 T501 T500 pobj 24,of
R218 T502 T501 amod non-BC,24
R219 T503 T501 cc and,24
R220 T504 T505 nummod 25,BC
R221 T505 T506 compound BC,individuals
R222 T506 T501 conj individuals,24
R223 T507 T468 punct .,measured
R224 T511 T512 compound CEBPG,factor
R225 T512 T514 nsubjpass factor,correlated
R227 T515 T514 auxpass was,correlated
R228 T516 T514 advmod significantly,correlated
R229 T517 T518 punct (,0.01
R230 T518 T516 parataxis 0.01,significantly
R233 T521 T518 punct ),0.01
R234 T522 T514 prep with,correlated
R235 T523 T522 pobj eight,with
R236 T524 T523 prep of,eight
R237 T525 T526 det the,genes
R238 T526 T524 pobj genes,of
R243 T531 T514 prep in,correlated
R244 T532 T533 amod non-BC,individuals
R245 T533 T531 pobj individuals,in
R246 T534 T531 cc but,in
R247 T535 T534 neg not,but
R248 T536 T531 conj in,in
R249 T537 T538 compound BC,individuals
R250 T538 T536 pobj individuals,in
R251 T539 T514 punct .,correlated
R252 T541 T542 prep In,was
R253 T543 T544 compound BC,individuals
R254 T544 T541 pobj individuals,In
R255 T545 T546 det the,correlation
R256 T546 T542 nsubj correlation,was
R257 T547 T546 prep with,correlation
R258 T548 T547 pobj CEBPG,with
R259 T549 T550 advmod significantly,lower
R260 T550 T542 acomp lower,was
R262 T552 T549 parataxis 0.01,significantly
R263 T553 T552 nsubj p,0.01
R264 T554 T552 punct <,0.01
R266 T556 T550 prep than,lower
R267 T557 T556 pobj that,than
R268 T558 T557 prep of,that
R269 T559 T560 amod non-BC,individuals
R270 T560 T558 pobj individuals,of
R271 T561 T542 prep for,was
R272 T562 T561 pobj four,for
R273 T563 T562 prep of,four
R274 T564 T565 det the,genes
R275 T565 T563 pobj genes,of
R276 T566 T562 punct (,four
R277 T567 T562 appos XRCC1,four
R278 T568 T567 punct ", ",XRCC1
R279 T569 T567 conj ERCC5,XRCC1
R280 T570 T569 punct ", ",ERCC5
R281 T571 T569 conj GSTP1,ERCC5
R282 T572 T571 punct ", ",GSTP1
R283 T573 T571 cc and,GSTP1
R284 T574 T571 conj SOD1,GSTP1
R285 T575 T542 punct ),was
R286 T576 T542 cc and,was
R287 T577 T578 det the,difference
R288 T578 T579 nsubj difference,was
R289 T579 T542 conj was,was
R290 T580 T581 advmod nearly,significant
R291 T581 T579 acomp significant,was
R292 T582 T579 prep for,was
R293 T583 T582 pobj GPX1,for
R294 T584 T579 punct .,was
R295 T586 T587 det The,factor
R296 T587 T591 nsubj factor,was
R300 T592 T587 acl correlated,factor
R301 T593 T592 prep with,correlated
R302 T594 T593 pobj any,with
R303 T595 T594 prep of,any
R304 T596 T597 det these,genes
R305 T597 T595 pobj genes,of
R308 T600 T592 prep in,correlated
R309 T601 T602 amod non-BC,individuals
R310 T602 T600 pobj individuals,in
R311 T603 T591 attr E2F1,was
R312 T604 T591 punct .,was
R313 T606 T607 nsubjpass E2F1,correlated
R314 T608 T607 auxpass was,correlated
R315 T609 T607 prep with,correlated
R316 T610 T609 pobj GSTP1,with
R317 T611 T607 prep among,correlated
R318 T612 T613 amod non-BC,individuals
R319 T613 T611 pobj individuals,among
R320 T614 T607 punct ", ",correlated
R321 T615 T607 cc but,correlated
R322 T616 T617 prep in,was
R323 T617 T607 conj was,correlated
R329 T623 T624 det no,difference
R330 T624 T617 attr difference,was
R332 T626 T624 prep in,difference
R333 T627 T628 det this,correlation
R334 T628 T626 pobj correlation,in
R335 T629 T624 prep in,difference
R336 T630 T631 amod non-BC,individuals
R337 T631 T629 pobj individuals,in
R338 T632 T624 prep compared,difference
R339 T633 T632 prep to,compared
R340 T634 T635 compound BC,individuals
R341 T635 T633 pobj individuals,to
R342 T636 T617 punct .,was
R343 T640 T641 nsubj We,conclude
R344 T642 T643 mark that,is
R345 T643 T641 ccomp is,conclude
R347 T645 T646 det the,factor
R348 T646 T643 attr factor,is
R350 T648 T649 advmod primarily,responsible
R351 T649 T646 amod responsible,factor
R352 T650 T649 prep for,responsible
R353 T651 T650 pcomp regulating,for
R354 T652 T651 dobj transcription,regulating
R355 T653 T652 prep of,transcription
R356 T654 T655 amod key,genes
R357 T655 T653 pobj genes,of
R362 T660 T643 prep in,is
R363 T661 T662 amod non-BC,individuals
R364 T662 T660 pobj individuals,in
R365 T663 T641 punct .,conclude
R366 T665 T666 advmod Further,conclude
R367 T667 T666 punct ", ",conclude
R368 T668 T666 nsubj we,conclude
R369 T669 T670 mark that,are
R370 T670 T666 ccomp are,conclude
R372 T672 T670 nsubj smokers,are
R373 T673 T672 amod heavy,smokers
R379 T679 T670 attr those,are
R380 T680 T681 dep who,have
R381 T681 T679 relcl have,those
R382 T682 T683 amod sub-optimal,regulation
R383 T683 T681 dobj regulation,have
R384 T684 T683 prep of,regulation
R385 T685 T686 nmod antioxidant,genes
R386 T686 T684 pobj genes,of
R390 T690 T683 prep by,regulation
R391 T691 T690 pobj CEBPG,by
R392 T692 T666 punct .,conclude
R25 T297 T296 amod primary,cause
R36 T308 T307 quantmod 10,15
R37 T309 T307 punct –,15
R40 T312 T310 prep of,%
R41 T313 T314 amod heavy,smokers
R42 T314 T312 pobj smokers,of
R50 T322 T323 det this,variation
R51 T323 T321 nsubjpass variation,determined
R52 T324 T323 prep in,variation
R53 T325 T324 pobj risk,in
R54 T326 T321 auxpass is,determined
R55 T327 T321 punct ", ",determined
R56 T328 T321 prep in,determined
R57 T329 T328 amod part,in
R58 T330 T321 punct ", ",determined
R59 T331 T321 advmod genetically,determined
R70 T344 T342 pobj which,for
R71 T345 T346 compound transcript,abundance
R72 T346 T343 nsubj abundance,was
R77 T351 T350 amod bronchial,cells
R78 T352 T350 amod epithelial,cells
R96 T372 T371 amod same,samples
R97 T373 T371 compound NBEC,samples
R101 T377 T376 compound abundance,values
R105 T381 T382 compound DNA,repair
R106 T382 T380 compound repair,genes
R111 T387 T386 compound antioxidant,genes
R120 T398 T399 nmod antioxidant,genes
R125 T403 T397 auxpass are,co-regulated
R129 T407 T405 cc or,one
R130 T408 T405 conj more,one
R131 T409 T406 compound transcription,factors
R135 T413 T414 amod inter-individual,variation
R136 T414 T412 nsubj variation,is
R137 T415 T414 prep in,variation
R138 T416 T415 pobj expression,in
R139 T417 T416 cc and,expression
R140 T418 T417 punct /,and
R141 T419 T417 cc or,and
R142 T420 T416 conj function,expression
R143 T421 T416 prep of,expression
R144 T422 T421 pobj one,of
R145 T423 T422 cc or,one
R146 T424 T422 conj more,one
R147 T425 T422 prep of,one
R148 T426 T427 det these,factors
R162 T443 T442 amod putative,sites
R163 T444 T445 compound transcription,factor
R164 T445 T446 compound factor,recognition
R165 T446 T442 compound recognition,sites
R172 T454 T453 compound antioxidant,genes
R178 T460 T461 compound DNA,sequence
R179 T461 T459 compound sequence,analysis
R183 T466 T465 compound transcript,values
R184 T467 T465 compound abundance,values
R188 T472 T471 compound transcription,factors
R191 T475 T474 nsubj n,6
R192 T476 T474 punct =,6
R197 T481 T480 amod expanded,group
R201 T485 T483 cc and,antioxidant
R202 T486 T487 compound DNA,repair
R203 T487 T483 conj repair,antioxidant
R206 T490 T489 nsubj n,16
R207 T491 T489 punct =,16
R226 T513 T512 compound transcription,factor
R231 T519 T518 nsubj p,0.01
R232 T520 T518 punct <,0.01
R239 T527 T526 nmod antioxidant,genes
R240 T528 T527 cc or,antioxidant
R241 T529 T530 compound DNA,repair
R242 T530 T527 conj repair,antioxidant
R261 T551 T552 punct (,0.01
R265 T555 T552 punct ),0.01
R297 T588 T587 amod only,factor
R298 T589 T587 amod other,factor
R299 T590 T587 compound transcription,factor
R306 T598 T597 nummod five,genes
R307 T599 T597 compound target,genes
R324 T618 T616 pobj contrast,in
R325 T619 T618 prep to,contrast
R326 T620 T619 pobj CEBPG,to
R327 T621 T617 punct ", ",was
R328 T622 T617 expl there,was
R331 T625 T624 amod significant,difference
R346 T644 T643 nsubj CEBPG,is
R349 T647 T646 compound transcription,factor
R358 T656 T655 nmod antioxidant,genes
R359 T657 T656 cc and,antioxidant
R360 T658 T659 compound DNA,repair
R361 T659 T656 conj repair,antioxidant
R371 T671 T672 det the,smokers
R374 T674 T672 acl selected,smokers
R375 T675 T674 prep for,selected
R376 T676 T675 pobj development,for
R377 T677 T676 prep of,development
R378 T678 T677 pobj BC,of
R387 T687 T685 cc and,antioxidant
R388 T688 T689 compound DNA,repair
R389 T689 T685 conj repair,antioxidant

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T109 184-195 SO_EXT:0000704 denotes genetically
T110 240-251 CHEBI_GO_EXT:antioxidant denotes antioxidant
T111 244-251 CHEBI_MOP_EXT:oxidising_agent_or_oxidation denotes oxidant
T112 252-257 SO_EXT:0000704 denotes genes
T113 268-278 SO_EXT:0000673 denotes transcript
T114 309-329 UBERON:0002031 denotes bronchial epithelial
T115 309-335 CL:0002328 denotes bronchial epithelial cells
T116 330-335 CL_GO_EXT:cell denotes cells
T117 349-360 NCBITaxon:1 denotes individuals
T118 380-391 NCBITaxon:1 denotes individuals
T119 442-452 SO_EXT:0000673 denotes transcript
T120 482-485 CHEBI_SO_EXT:DNA denotes DNA
T121 482-492 GO:0006281 denotes DNA repair
T122 493-498 SO_EXT:0000704 denotes genes
T123 526-537 CHEBI_GO_EXT:antioxidant denotes antioxidant
T124 530-537 CHEBI_MOP_EXT:oxidising_agent_or_oxidation denotes oxidant
T125 538-543 SO_EXT:0000704 denotes genes
T126 583-594 CHEBI_GO_EXT:antioxidant denotes antioxidant
T127 587-594 CHEBI_MOP_EXT:oxidising_agent_or_oxidation denotes oxidant
T128 599-602 CHEBI_SO_EXT:DNA denotes DNA
T129 599-609 GO:0006281 denotes DNA repair
T130 610-615 SO_EXT:0000704 denotes genes
T131 623-632 GO:0065007 denotes regulated
T132 648-661 GO_EXT:transcription denotes transcription
T133 648-669 GO_EXT:transcription_factor denotes transcription factors
T134 685-695 NCBITaxon:1 denotes individual
T135 709-719 GO:0010467 denotes expression
T136 760-773 GO_EXT:transcription denotes transcription
T137 760-781 GO_EXT:transcription_factor denotes transcription factors
T138 807-817 NCBITaxon:1 denotes individual
T139 866-879 GO_EXT:transcription denotes transcription
T140 866-886 GO_EXT:transcription_factor denotes transcription factor
T141 866-904 SO_EXT:0000235 denotes transcription factor recognition sites
T142 926-937 CHEBI_GO_EXT:antioxidant denotes antioxidant
T143 930-937 CHEBI_MOP_EXT:oxidising_agent_or_oxidation denotes oxidant
T144 938-943 SO_EXT:0000704 denotes genes
T145 978-981 CHEBI_SO_EXT:DNA denotes DNA
T146 982-990 SO_EXT:biological_sequence denotes sequence
T147 1005-1015 SO_EXT:0000673 denotes transcript
T148 1042-1055 GO_EXT:transcription denotes transcription
T149 1042-1063 GO_EXT:transcription_factor denotes transcription factors
T150 1097-1108 CHEBI_GO_EXT:antioxidant denotes antioxidant
T151 1101-1108 CHEBI_MOP_EXT:oxidising_agent_or_oxidation denotes oxidant
T152 1113-1116 CHEBI_SO_EXT:DNA denotes DNA
T153 1113-1123 GO:0006281 denotes DNA repair
T154 1124-1129 SO_EXT:0000704 denotes genes
T155 1219-1230 NCBITaxon:1 denotes individuals
T156 1241-1246 PR_EXT:000005311 denotes CEBPG
T157 1247-1260 GO_EXT:transcription denotes transcription
T158 1247-1267 GO_EXT:transcription_factor denotes transcription factor
T159 1326-1337 CHEBI_GO_EXT:antioxidant denotes antioxidant
T160 1330-1337 CHEBI_MOP_EXT:oxidising_agent_or_oxidation denotes oxidant
T161 1341-1344 CHEBI_SO_EXT:DNA denotes DNA
T162 1341-1351 GO:0006281 denotes DNA repair
T163 1352-1357 SO_EXT:0000704 denotes genes
T164 1368-1379 NCBITaxon:1 denotes individuals
T165 1394-1405 NCBITaxon:1 denotes individuals
T166 1413-1424 NCBITaxon:1 denotes individuals
T167 1446-1451 PR_EXT:000005311 denotes CEBPG
T168 1507-1518 NCBITaxon:1 denotes individuals
T169 1535-1540 SO_EXT:0000704 denotes genes
T170 1542-1547 PR_EXT:000017504 denotes XRCC1
T171 1549-1554 PR_EXT:000007167 denotes ERCC5
T172 1556-1561 PR_EXT:000029950 denotes GSTP1
T173 1567-1571 PR_EXT:000015399 denotes SOD1
T174 1619-1623 PR_EXT:000008210 denotes GPX1
T175 1640-1653 GO_EXT:transcription denotes transcription
T176 1640-1660 GO_EXT:transcription_factor denotes transcription factor
T177 1702-1707 SO_EXT:0000704 denotes genes
T178 1718-1729 NCBITaxon:1 denotes individuals
T179 1734-1738 PR_EXT:000006852 denotes E2F1
T180 1740-1744 PR_EXT:000006852 denotes E2F1
T181 1765-1770 PR_EXT:000029950 denotes GSTP1
T182 1784-1795 NCBITaxon:1 denotes individuals
T183 1816-1821 PR_EXT:000005311 denotes CEBPG
T184 1889-1900 NCBITaxon:1 denotes individuals
T185 1916-1927 NCBITaxon:1 denotes individuals
T186 1958-1963 PR_EXT:000005311 denotes CEBPG
T187 1971-1984 GO_EXT:transcription denotes transcription
T188 1971-1991 GO_EXT:transcription_factor denotes transcription factor
T189 2018-2028 GO:0065007 denotes regulating
T190 2029-2042 GO_EXT:transcription denotes transcription
T191 2050-2061 CHEBI_GO_EXT:antioxidant denotes antioxidant
T192 2054-2061 CHEBI_MOP_EXT:oxidising_agent_or_oxidation denotes oxidant
T193 2066-2069 CHEBI_SO_EXT:DNA denotes DNA
T194 2066-2076 GO:0006281 denotes DNA repair
T195 2077-2082 SO_EXT:0000704 denotes genes
T196 2093-2104 NCBITaxon:1 denotes individuals
T197 2212-2222 GO:0065007 denotes regulation
T198 2226-2237 CHEBI_GO_EXT:antioxidant denotes antioxidant
T199 2230-2237 CHEBI_MOP_EXT:oxidising_agent_or_oxidation denotes oxidant
T200 2242-2245 CHEBI_SO_EXT:DNA denotes DNA
T201 2242-2252 GO:0006281 denotes DNA repair
T202 2253-2258 SO_EXT:0000704 denotes genes
T203 2262-2267 PR_EXT:000005311 denotes CEBPG

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T210 184-195 SO:0000704 denotes genetically
T211 252-257 SO:0000704 denotes genes
T212 268-278 SO:0000673 denotes transcript
T213 309-329 UBERON:0002031 denotes bronchial epithelial
T214 309-335 CL:0002328 denotes bronchial epithelial cells
T215 349-360 NCBITaxon:1 denotes individuals
T216 380-391 NCBITaxon:1 denotes individuals
T217 442-452 SO:0000673 denotes transcript
T218 482-492 GO:0006281 denotes DNA repair
T219 493-498 SO:0000704 denotes genes
T220 538-543 SO:0000704 denotes genes
T221 599-609 GO:0006281 denotes DNA repair
T222 610-615 SO:0000704 denotes genes
T223 623-632 GO:0065007 denotes regulated
T224 685-695 NCBITaxon:1 denotes individual
T225 709-719 GO:0010467 denotes expression
T226 807-817 NCBITaxon:1 denotes individual
T227 866-904 SO:0000235 denotes transcription factor recognition sites
T228 938-943 SO:0000704 denotes genes
T229 1005-1015 SO:0000673 denotes transcript
T230 1113-1123 GO:0006281 denotes DNA repair
T231 1124-1129 SO:0000704 denotes genes
T232 1219-1230 NCBITaxon:1 denotes individuals
T233 1241-1246 PR:000005311 denotes CEBPG
T234 1341-1351 GO:0006281 denotes DNA repair
T235 1352-1357 SO:0000704 denotes genes
T236 1368-1379 NCBITaxon:1 denotes individuals
T237 1394-1405 NCBITaxon:1 denotes individuals
T238 1413-1424 NCBITaxon:1 denotes individuals
T239 1446-1451 PR:000005311 denotes CEBPG
T240 1507-1518 NCBITaxon:1 denotes individuals
T241 1535-1540 SO:0000704 denotes genes
T242 1542-1547 PR:000017504 denotes XRCC1
T243 1549-1554 PR:000007167 denotes ERCC5
T244 1556-1561 PR:000029950 denotes GSTP1
T245 1567-1571 PR:000015399 denotes SOD1
T246 1619-1623 PR:000008210 denotes GPX1
T247 1702-1707 SO:0000704 denotes genes
T248 1718-1729 NCBITaxon:1 denotes individuals
T249 1734-1738 PR:000006852 denotes E2F1
T250 1740-1744 PR:000006852 denotes E2F1
T251 1765-1770 PR:000029950 denotes GSTP1
T252 1784-1795 NCBITaxon:1 denotes individuals
T253 1816-1821 PR:000005311 denotes CEBPG
T254 1889-1900 NCBITaxon:1 denotes individuals
T255 1916-1927 NCBITaxon:1 denotes individuals
T256 1958-1963 PR:000005311 denotes CEBPG
T257 2018-2028 GO:0065007 denotes regulating
T258 2066-2076 GO:0006281 denotes DNA repair
T259 2077-2082 SO:0000704 denotes genes
T260 2093-2104 NCBITaxon:1 denotes individuals
T261 2212-2222 GO:0065007 denotes regulation
T262 2242-2252 GO:0006281 denotes DNA repair
T263 2253-2258 SO:0000704 denotes genes
T264 2262-2267 PR:000005311 denotes CEBPG