PMC:1310620 JSON TXT

Annnotations TAB JSON ListView MergeView

craft-sa-dev

Id	Subject	Object	Predicate	Lexical cue
T266	20-26	NN	denotes	factor
T267	0-163	sentence	denotes	CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma
T268	6-19	NN	denotes	transcription
T269	27-37	VBZ	denotes	correlates
T270	38-42	IN	denotes	with
T271	43-54	NN	denotes	antioxidant
T272	70-75	NNS	denotes	genes
T273	55-58	CC	denotes	and
T274	59-62	NN	denotes	DNA
T275	63-69	NN	denotes	repair
T276	76-78	IN	denotes	in
T277	79-85	JJ	denotes	normal
T278	107-112	NNS	denotes	cells
T279	86-95	JJ	denotes	bronchial
T280	96-106	JJ	denotes	epithelial
T281	113-116	CC	denotes	but
T282	117-120	RB	denotes	not
T283	121-123	IN	denotes	in
T284	124-135	NNS	denotes	individuals
T285	136-140	IN	denotes	with
T286	141-153	JJ	denotes	bronchogenic
T287	154-163	NN	denotes	carcinoma
T288	163-164	sentence	denotes
T289	174-184	sentence	denotes	Background
T290	174-184	NN	denotes	Background
T291	184-381	sentence	denotes	Cigarette smoking is the primary cause of bronchogenic carcinoma (BC), yet only 10–15% of heavy smokers develop BC and it is likely that this variation in risk is, in part, genetically determined.
T292	185-194	NN	denotes	Cigarette
T293	195-202	NN	denotes	smoking
T294	203-205	VBZ	denotes	is
T295	206-209	DT	denotes	the
T296	218-223	NN	denotes	cause
T297	210-217	JJ	denotes	primary
T298	224-226	IN	denotes	of
T299	227-239	JJ	denotes	bronchogenic
T300	240-249	NN	denotes	carcinoma
T301	250-251	-LRB-	denotes	(
T302	251-253	NN	denotes	BC
T303	253-254	-RRB-	denotes	)
T304	254-256	,	denotes	,
T305	256-259	CC	denotes	yet
T306	260-264	RB	denotes	only
T307	268-270	CD	denotes	15
T308	265-267	CD	denotes	10
T309	267-268	SYM	denotes	–
T310	270-271	NN	denotes	%
T311	289-296	VBP	denotes	develop
T312	272-274	IN	denotes	of
T313	275-280	JJ	denotes	heavy
T314	281-288	NNS	denotes	smokers
T315	297-299	NN	denotes	BC
T316	300-303	CC	denotes	and
T317	304-306	PRP	denotes	it
T318	307-309	VBZ	denotes	is
T319	310-316	JJ	denotes	likely
T320	317-321	IN	denotes	that
T321	370-380	VBN	denotes	determined
T322	322-326	DT	denotes	this
T323	327-336	NN	denotes	variation
T324	337-339	IN	denotes	in
T325	340-344	NN	denotes	risk
T326	345-347	VBZ	denotes	is
T327	347-349	,	denotes	,
T328	349-351	IN	denotes	in
T329	352-356	JJ	denotes	part
T330	356-358	,	denotes	,
T331	358-369	RB	denotes	genetically
T332	380-381	.	denotes	.
T333	381-566	sentence	denotes	We previously reported a set of antioxidant genes for which transcript abundance was lower in normal bronchial epithelial cells (NBEC) of BC individuals compared to non-BC individuals.
T334	382-384	PRP	denotes	We
T335	396-404	VBD	denotes	reported
T336	385-395	RB	denotes	previously
T337	405-406	DT	denotes	a
T338	407-410	NN	denotes	set
T339	411-413	IN	denotes	of
T340	414-425	NN	denotes	antioxidant
T341	426-431	NNS	denotes	genes
T342	432-435	IN	denotes	for
T343	463-466	VBD	denotes	was
T344	436-441	WDT	denotes	which
T345	442-452	NN	denotes	transcript
T346	453-462	NN	denotes	abundance
T347	467-472	JJR	denotes	lower
T348	473-475	IN	denotes	in
T349	476-482	JJ	denotes	normal
T350	504-509	NNS	denotes	cells
T351	483-492	JJ	denotes	bronchial
T352	493-503	JJ	denotes	epithelial
T353	510-511	-LRB-	denotes	(
T354	511-515	NN	denotes	NBEC
T355	515-516	-RRB-	denotes	)
T356	517-519	IN	denotes	of
T357	520-522	NN	denotes	BC
T358	523-534	NNS	denotes	individuals
T359	535-543	VBN	denotes	compared
T360	544-546	IN	denotes	to
T361	547-553	JJ	denotes	non-BC
T362	554-565	NNS	denotes	individuals
T363	565-566	.	denotes	.
T364	566-718	sentence	denotes	In unpublished studies of the same NBEC samples, transcript abundance values for several DNA repair genes were correlated with these antioxidant genes.
T365	567-569	IN	denotes	In
T366	678-688	VBN	denotes	correlated
T367	570-581	JJ	denotes	unpublished
T368	582-589	NNS	denotes	studies
T369	590-592	IN	denotes	of
T370	593-596	DT	denotes	the
T371	607-614	NNS	denotes	samples
T372	597-601	JJ	denotes	same
T373	602-606	NN	denotes	NBEC
T374	614-616	,	denotes	,
T375	616-626	NN	denotes	transcript
T376	637-643	NNS	denotes	values
T377	627-636	NN	denotes	abundance
T378	644-647	IN	denotes	for
T379	648-655	JJ	denotes	several
T380	667-672	NNS	denotes	genes
T381	656-659	NN	denotes	DNA
T382	660-666	NN	denotes	repair
T383	673-677	VBD	denotes	were
T384	689-693	IN	denotes	with
T385	694-699	DT	denotes	these
T386	712-717	NNS	denotes	genes
T387	700-711	NN	denotes	antioxidant
T388	717-718	.	denotes	.
T389	718-1017	sentence	denotes	From these data, we hypothesized that antioxidant and DNA repair genes are co-regulated by one or more transcription factors and that inter-individual variation in expression and/or function of one or more of these transcription factors is responsible for inter-individual variation in risk for BC.
T390	719-723	IN	denotes	From
T391	739-751	VBD	denotes	hypothesized
T392	724-729	DT	denotes	these
T393	730-734	NNS	denotes	data
T394	734-736	,	denotes	,
T395	736-738	PRP	denotes	we
T396	752-756	IN	denotes	that
T397	794-806	VBN	denotes	co-regulated
T398	757-768	NN	denotes	antioxidant
T399	784-789	NNS	denotes	genes
T400	769-772	CC	denotes	and
T401	773-776	NN	denotes	DNA
T402	777-783	NN	denotes	repair
T403	790-793	VBP	denotes	are
T404	807-809	IN	denotes	by
T405	810-813	CD	denotes	one
T406	836-843	NNS	denotes	factors
T407	814-816	CC	denotes	or
T408	817-821	JJR	denotes	more
T409	822-835	NN	denotes	transcription
T410	844-847	CC	denotes	and
T411	848-852	IN	denotes	that
T412	956-958	VBZ	denotes	is
T413	853-869	JJ	denotes	inter-individual
T414	870-879	NN	denotes	variation
T415	880-882	IN	denotes	in
T416	883-893	NN	denotes	expression
T417	894-897	CC	denotes	and
T418	897-898	HYPH	denotes	/
T419	898-900	CC	denotes	or
T420	901-909	NN	denotes	function
T421	910-912	IN	denotes	of
T422	913-916	CD	denotes	one
T423	917-919	CC	denotes	or
T424	920-924	JJR	denotes	more
T425	925-927	IN	denotes	of
T426	928-933	DT	denotes	these
T427	948-955	NNS	denotes	factors
T428	934-947	NN	denotes	transcription
T429	959-970	JJ	denotes	responsible
T430	971-974	IN	denotes	for
T431	975-991	JJ	denotes	inter-individual
T432	992-1001	NN	denotes	variation
T433	1002-1004	IN	denotes	in
T434	1005-1009	NN	denotes	risk
T435	1010-1013	IN	denotes	for
T436	1014-1016	NN	denotes	BC
T437	1016-1017	.	denotes	.
T438	1017-1026	sentence	denotes	Methods
T439	1019-1026	NNS	denotes	Methods
T440	1026-1174	sentence	denotes	The putative transcription factor recognition sites common to six of the antioxidant genes were identified through in silico DNA sequence analysis.
T441	1027-1030	DT	denotes	The
T442	1073-1078	NNS	denotes	sites
T443	1031-1039	JJ	denotes	putative
T444	1040-1053	NN	denotes	transcription
T445	1054-1060	NN	denotes	factor
T446	1061-1072	NN	denotes	recognition
T447	1123-1133	VBN	denotes	identified
T448	1079-1085	JJ	denotes	common
T449	1086-1088	IN	denotes	to
T450	1089-1092	CD	denotes	six
T451	1093-1095	IN	denotes	of
T452	1096-1099	DT	denotes	the
T453	1112-1117	NNS	denotes	genes
T454	1100-1111	NN	denotes	antioxidant
T455	1118-1122	VBD	denotes	were
T456	1134-1141	IN	denotes	through
T457	1142-1144	FW	denotes	in
T458	1145-1151	FW	denotes	silico
T459	1165-1173	NN	denotes	analysis
T460	1152-1155	NN	denotes	DNA
T461	1156-1164	NN	denotes	sequence
T462	1173-1174	.	denotes	.
T463	1174-1405	sentence	denotes	The transcript abundance values of these transcription factors (n = 6) and an expanded group of antioxidant and DNA repair genes (n = 16) were measured simultaneously by quantitative PCR in NBEC of 24 non-BC and 25 BC individuals.
T464	1175-1178	DT	denotes	The
T465	1200-1206	NNS	denotes	values
T466	1179-1189	NN	denotes	transcript
T467	1190-1199	NN	denotes	abundance
T468	1318-1326	VBN	denotes	measured
T469	1207-1209	IN	denotes	of
T470	1210-1215	DT	denotes	these
T471	1230-1237	NNS	denotes	factors
T472	1216-1229	NN	denotes	transcription
T473	1238-1239	-LRB-	denotes	(
T474	1243-1244	CD	denotes	6
T475	1239-1240	NN	denotes	n
T476	1241-1242	SYM	denotes	=
T477	1244-1245	-RRB-	denotes	)
T478	1246-1249	CC	denotes	and
T479	1250-1252	DT	denotes	an
T480	1262-1267	NN	denotes	group
T481	1253-1261	VBN	denotes	expanded
T482	1268-1270	IN	denotes	of
T483	1271-1282	NN	denotes	antioxidant
T484	1298-1303	NNS	denotes	genes
T485	1283-1286	CC	denotes	and
T486	1287-1290	NN	denotes	DNA
T487	1291-1297	NN	denotes	repair
T488	1304-1305	-LRB-	denotes	(
T489	1309-1311	CD	denotes	16
T490	1305-1306	NN	denotes	n
T491	1307-1308	SYM	denotes	=
T492	1311-1312	-RRB-	denotes	)
T493	1313-1317	VBD	denotes	were
T494	1327-1341	RB	denotes	simultaneously
T495	1342-1344	IN	denotes	by
T496	1345-1357	JJ	denotes	quantitative
T497	1358-1361	NN	denotes	PCR
T498	1362-1364	IN	denotes	in
T499	1365-1369	NN	denotes	NBEC
T500	1370-1372	IN	denotes	of
T501	1373-1375	CD	denotes	24
T502	1376-1382	JJ	denotes	non-BC
T503	1383-1386	CC	denotes	and
T504	1387-1389	CD	denotes	25
T505	1390-1392	NN	denotes	BC
T506	1393-1404	NNS	denotes	individuals
T507	1404-1405	.	denotes	.
T508	1405-1414	sentence	denotes	Results
T509	1407-1414	NNS	denotes	Results
T510	1414-1580	sentence	denotes	CEBPG transcription factor was significantly (p < 0.01) correlated with eight of the antioxidant or DNA repair genes in non-BC individuals but not in BC individuals.
T511	1415-1420	NN	denotes	CEBPG
T512	1435-1441	NN	denotes	factor
T513	1421-1434	NN	denotes	transcription
T514	1471-1481	VBN	denotes	correlated
T515	1442-1445	VBD	denotes	was
T516	1446-1459	RB	denotes	significantly
T517	1460-1461	-LRB-	denotes	(
T518	1465-1469	CD	denotes	0.01
T519	1461-1462	NN	denotes	p
T520	1463-1464	SYM	denotes	<
T521	1469-1470	-RRB-	denotes	)
T522	1482-1486	IN	denotes	with
T523	1487-1492	CD	denotes	eight
T524	1493-1495	IN	denotes	of
T525	1496-1499	DT	denotes	the
T526	1526-1531	NNS	denotes	genes
T527	1500-1511	NN	denotes	antioxidant
T528	1512-1514	CC	denotes	or
T529	1515-1518	NN	denotes	DNA
T530	1519-1525	NN	denotes	repair
T531	1532-1534	IN	denotes	in
T532	1535-1541	JJ	denotes	non-BC
T533	1542-1553	NNS	denotes	individuals
T534	1554-1557	CC	denotes	but
T535	1558-1561	RB	denotes	not
T536	1562-1564	IN	denotes	in
T537	1565-1567	NN	denotes	BC
T538	1568-1579	NNS	denotes	individuals
T539	1579-1580	.	denotes	.
T540	1580-1798	sentence	denotes	In BC individuals the correlation with CEBPG was significantly (p < 0.01) lower than that of non-BC individuals for four of the genes (XRCC1, ERCC5, GSTP1, and SOD1) and the difference was nearly significant for GPX1.
T541	1581-1583	IN	denotes	In
T542	1626-1629	VBD	denotes	was
T543	1584-1586	NN	denotes	BC
T544	1587-1598	NNS	denotes	individuals
T545	1599-1602	DT	denotes	the
T546	1603-1614	NN	denotes	correlation
T547	1615-1619	IN	denotes	with
T548	1620-1625	NN	denotes	CEBPG
T549	1630-1643	RB	denotes	significantly
T550	1655-1660	JJR	denotes	lower
T551	1644-1645	-LRB-	denotes	(
T552	1649-1653	CD	denotes	0.01
T553	1645-1646	NN	denotes	p
T554	1647-1648	SYM	denotes	<
T555	1653-1654	-RRB-	denotes	)
T556	1661-1665	IN	denotes	than
T557	1666-1670	DT	denotes	that
T558	1671-1673	IN	denotes	of
T559	1674-1680	JJ	denotes	non-BC
T560	1681-1692	NNS	denotes	individuals
T561	1693-1696	IN	denotes	for
T562	1697-1701	CD	denotes	four
T563	1702-1704	IN	denotes	of
T564	1705-1708	DT	denotes	the
T565	1709-1714	NNS	denotes	genes
T566	1715-1716	-LRB-	denotes	(
T567	1716-1721	NN	denotes	XRCC1
T568	1721-1723	,	denotes	,
T569	1723-1728	NN	denotes	ERCC5
T570	1728-1730	,	denotes	,
T571	1730-1735	NN	denotes	GSTP1
T572	1735-1737	,	denotes	,
T573	1737-1740	CC	denotes	and
T574	1741-1745	NN	denotes	SOD1
T575	1745-1746	-RRB-	denotes	)
T576	1747-1750	CC	denotes	and
T577	1751-1754	DT	denotes	the
T578	1755-1765	NN	denotes	difference
T579	1766-1769	VBD	denotes	was
T580	1770-1776	RB	denotes	nearly
T581	1777-1788	JJ	denotes	significant
T582	1789-1792	IN	denotes	for
T583	1793-1797	NN	denotes	GPX1
T584	1797-1798	.	denotes	.
T585	1798-1913	sentence	denotes	The only other transcription factor correlated with any of these five target genes in non-BC individuals was E2F1.
T586	1799-1802	DT	denotes	The
T587	1828-1834	NN	denotes	factor
T588	1803-1807	JJ	denotes	only
T589	1808-1813	JJ	denotes	other
T590	1814-1827	NN	denotes	transcription
T591	1904-1907	VBD	denotes	was
T592	1835-1845	VBN	denotes	correlated
T593	1846-1850	IN	denotes	with
T594	1851-1854	DT	denotes	any
T595	1855-1857	IN	denotes	of
T596	1858-1863	DT	denotes	these
T597	1876-1881	NNS	denotes	genes
T598	1864-1868	CD	denotes	five
T599	1869-1875	NN	denotes	target
T600	1882-1884	IN	denotes	in
T601	1885-1891	JJ	denotes	non-BC
T602	1892-1903	NNS	denotes	individuals
T603	1908-1912	NN	denotes	E2F1
T604	1912-1913	.	denotes	.
T605	1913-2102	sentence	denotes	E2F1 was correlated with GSTP1 among non-BC individuals, but in contrast to CEBPG, there was no significant difference in this correlation in non-BC individuals compared to BC individuals.
T606	1914-1918	NN	denotes	E2F1
T607	1923-1933	VBN	denotes	correlated
T608	1919-1922	VBD	denotes	was
T609	1934-1938	IN	denotes	with
T610	1939-1944	NN	denotes	GSTP1
T611	1945-1950	IN	denotes	among
T612	1951-1957	JJ	denotes	non-BC
T613	1958-1969	NNS	denotes	individuals
T614	1969-1971	,	denotes	,
T615	1971-1974	CC	denotes	but
T616	1975-1977	IN	denotes	in
T617	2003-2006	VBD	denotes	was
T618	1978-1986	NN	denotes	contrast
T619	1987-1989	IN	denotes	to
T620	1990-1995	NN	denotes	CEBPG
T621	1995-1997	,	denotes	,
T622	1997-2002	EX	denotes	there
T623	2007-2009	DT	denotes	no
T624	2022-2032	NN	denotes	difference
T625	2010-2021	JJ	denotes	significant
T626	2033-2035	IN	denotes	in
T627	2036-2040	DT	denotes	this
T628	2041-2052	NN	denotes	correlation
T629	2053-2055	IN	denotes	in
T630	2056-2062	JJ	denotes	non-BC
T631	2063-2074	NNS	denotes	individuals
T632	2075-2083	VBN	denotes	compared
T633	2084-2086	IN	denotes	to
T634	2087-2089	NN	denotes	BC
T635	2090-2101	NNS	denotes	individuals
T636	2101-2102	.	denotes	.
T637	2102-2114	sentence	denotes	Conclusion
T638	2104-2114	NN	denotes	Conclusion
T639	2114-2279	sentence	denotes	We conclude that CEBPG is the transcription factor primarily responsible for regulating transcription of key antioxidant and DNA repair genes in non-BC individuals.
T640	2115-2117	PRP	denotes	We
T641	2118-2126	VBP	denotes	conclude
T642	2127-2131	IN	denotes	that
T643	2138-2140	VBZ	denotes	is
T644	2132-2137	NN	denotes	CEBPG
T645	2141-2144	DT	denotes	the
T646	2159-2165	NN	denotes	factor
T647	2145-2158	NN	denotes	transcription
T648	2166-2175	RB	denotes	primarily
T649	2176-2187	JJ	denotes	responsible
T650	2188-2191	IN	denotes	for
T651	2192-2202	VBG	denotes	regulating
T652	2203-2216	NN	denotes	transcription
T653	2217-2219	IN	denotes	of
T654	2220-2223	JJ	denotes	key
T655	2251-2256	NNS	denotes	genes
T656	2224-2235	NN	denotes	antioxidant
T657	2236-2239	CC	denotes	and
T658	2240-2243	NN	denotes	DNA
T659	2244-2250	NN	denotes	repair
T660	2257-2259	IN	denotes	in
T661	2260-2266	JJ	denotes	non-BC
T662	2267-2278	NNS	denotes	individuals
T663	2278-2279	.	denotes	.
T664	2279-2442	sentence	denotes	Further, we conclude that the heavy smokers selected for development of BC are those who have sub-optimal regulation of antioxidant and DNA repair genes by CEBPG.
T665	2280-2287	RB	denotes	Further
T666	2292-2300	VBP	denotes	conclude
T667	2287-2289	,	denotes	,
T668	2289-2291	PRP	denotes	we
T669	2301-2305	IN	denotes	that
T670	2355-2358	VBP	denotes	are
T671	2306-2309	DT	denotes	the
T672	2316-2323	NNS	denotes	smokers
T673	2310-2315	JJ	denotes	heavy
T674	2324-2332	VBN	denotes	selected
T675	2333-2336	IN	denotes	for
T676	2337-2348	NN	denotes	development
T677	2349-2351	IN	denotes	of
T678	2352-2354	NN	denotes	BC
T679	2359-2364	DT	denotes	those
T680	2365-2368	WP	denotes	who
T681	2369-2373	VBP	denotes	have
T682	2374-2385	JJ	denotes	sub-optimal
T683	2386-2396	NN	denotes	regulation
T684	2397-2399	IN	denotes	of
T685	2400-2411	NN	denotes	antioxidant
T686	2427-2432	NNS	denotes	genes
T687	2412-2415	CC	denotes	and
T688	2416-2419	NN	denotes	DNA
T689	2420-2426	NN	denotes	repair
T690	2433-2435	IN	denotes	by
T691	2436-2441	NN	denotes	CEBPG
T692	2441-2442	.	denotes	.
T923	2455-2457	NN	denotes	BC
T924	2458-2460	VBZ	denotes	is
T925	2461-2470	RB	denotes	currently
T926	2471-2474	DT	denotes	the
T927	2483-2488	NN	denotes	cause
T928	2475-2482	VBG	denotes	leading
T929	2489-2491	IN	denotes	of
T930	2492-2498	NN	denotes	cancer
T931	2499-2506	VBN	denotes	related
T932	2498-2499	HYPH	denotes	-
T933	2507-2512	NN	denotes	death
T934	2513-2515	IN	denotes	in
T935	2516-2519	DT	denotes	the
T936	2527-2533	NNP	denotes	States
T937	2520-2526	NNP	denotes	United
T938	2533-2535	,	denotes	,
T939	2535-2542	VBG	denotes	causing
T940	2543-2545	CD	denotes	28
T941	2545-2546	NN	denotes	%
T942	2547-2549	IN	denotes	of
T943	2550-2553	DT	denotes	all
T944	2561-2567	NNS	denotes	deaths
T945	2554-2560	NN	denotes	cancer
T946	2568-2569	-LRB-	denotes	[
T947	2569-2570	CD	denotes	1
T948	2570-2571	-RRB-	denotes	]
T949	2571-2572	.	denotes	.
T950	2572-2703	sentence	denotes	Although cigarette smoking is the primary risk factor, only 10–15% of heavy smokers (greater than 20 pack years) develop BC [1-3].
T951	2573-2581	IN	denotes	Although
T952	2600-2602	VBZ	denotes	is
T953	2582-2591	NN	denotes	cigarette
T954	2592-2599	NN	denotes	smoking
T955	2686-2693	VBP	denotes	develop
T956	2603-2606	DT	denotes	the
T957	2620-2626	NN	denotes	factor
T958	2607-2614	JJ	denotes	primary
T959	2615-2619	NN	denotes	risk
T960	2626-2628	,	denotes	,
T961	2628-2632	RB	denotes	only
T962	2636-2638	CD	denotes	15
T963	2633-2635	CD	denotes	10
T964	2635-2636	SYM	denotes	–
T965	2638-2639	NN	denotes	%
T966	2640-2642	IN	denotes	of
T967	2643-2648	JJ	denotes	heavy
T968	2649-2656	NNS	denotes	smokers
T969	2657-2658	-LRB-	denotes	(
T970	2679-2684	NNS	denotes	years
T971	2658-2665	JJR	denotes	greater
T972	2671-2673	CD	denotes	20
T973	2666-2670	IN	denotes	than
T974	2674-2678	NN	denotes	pack
T975	2684-2685	-RRB-	denotes	)
T976	2694-2696	NN	denotes	BC
T977	2697-2698	-LRB-	denotes	[
T978	2698-2699	CD	denotes	1
T979	2699-2700	SYM	denotes	-
T980	2700-2701	CD	denotes	3
T981	2701-2702	-RRB-	denotes	]
T982	2702-2703	.	denotes	.
T983	2703-2890	sentence	denotes	Antioxidant and DNA repair enzymes that provide protection from the effects of cigarette smoke are expressed in the progenitor cells for BC, normal bronchial epithelial cells (NBEC) [1].
T984	2704-2715	NN	denotes	Antioxidant
T985	2731-2738	NNS	denotes	enzymes
T986	2716-2719	CC	denotes	and
T987	2720-2723	NN	denotes	DNA
T988	2724-2730	NN	denotes	repair
T989	2803-2812	VBN	denotes	expressed
T990	2739-2743	WDT	denotes	that
T991	2744-2751	VBP	denotes	provide
T992	2752-2762	NN	denotes	protection
T993	2763-2767	IN	denotes	from
T994	2768-2771	DT	denotes	the
T995	2772-2779	NNS	denotes	effects
T996	2780-2782	IN	denotes	of
T997	2783-2792	NN	denotes	cigarette
T998	2793-2798	NN	denotes	smoke
T999	2799-2802	VBP	denotes	are
T1000	2813-2815	IN	denotes	in
T1001	2816-2819	DT	denotes	the
T1002	2831-2836	NNS	denotes	cells
T1003	2820-2830	NN	denotes	progenitor
T1004	2837-2840	IN	denotes	for
T1005	2841-2843	NN	denotes	BC
T1006	2843-2845	,	denotes	,
T1007	2845-2851	JJ	denotes	normal
T1008	2873-2878	NNS	denotes	cells
T1009	2852-2861	JJ	denotes	bronchial
T1010	2862-2872	JJ	denotes	epithelial
T1011	2879-2880	-LRB-	denotes	(
T1012	2880-2884	NN	denotes	NBEC
T1013	2884-2885	-RRB-	denotes	)
T1014	2886-2887	-LRB-	denotes	[
T1015	2887-2888	CD	denotes	1
T1016	2888-2889	-RRB-	denotes	]
T1017	2889-2890	.	denotes	.
T1018	2890-3005	sentence	denotes	Inherited inter-individual variation in the function of these genes plays a role in determining risk for BC [4-6].
T1019	2891-2900	VBN	denotes	Inherited
T1020	2918-2927	NN	denotes	variation
T1021	2901-2917	JJ	denotes	inter-individual
T1022	2959-2964	VBZ	denotes	plays
T1023	2928-2930	IN	denotes	in
T1024	2931-2934	DT	denotes	the
T1025	2935-2943	NN	denotes	function
T1026	2944-2946	IN	denotes	of
T1027	2947-2952	DT	denotes	these
T1028	2953-2958	NNS	denotes	genes
T1029	2965-2966	DT	denotes	a
T1030	2967-2971	NN	denotes	role
T1031	2972-2974	IN	denotes	in
T1032	2975-2986	VBG	denotes	determining
T1033	2987-2991	NN	denotes	risk
T1034	2992-2995	IN	denotes	for
T1035	2996-2998	NN	denotes	BC
T1036	2999-3000	-LRB-	denotes	[
T1037	3000-3001	CD	denotes	4
T1038	3001-3002	SYM	denotes	-
T1039	3002-3003	CD	denotes	6
T1040	3003-3004	-RRB-	denotes	]
T1041	3004-3005	.	denotes	.
T1042	3005-3227	sentence	denotes	Antioxidant enzymes protect NBEC from reactive oxygen species produced by interaction with and metabolism of xenobiotics such as pollution and cigarette smoke [4-7] as well as those produced by normal cellular metabolism.
T1043	3006-3017	NN	denotes	Antioxidant
T1044	3018-3025	NNS	denotes	enzymes
T1045	3026-3033	VBP	denotes	protect
T1046	3034-3038	NN	denotes	NBEC
T1047	3039-3043	IN	denotes	from
T1048	3044-3052	JJ	denotes	reactive
T1049	3060-3067	NNS	denotes	species
T1050	3053-3059	NN	denotes	oxygen
T1051	3068-3076	VBN	denotes	produced
T1052	3077-3079	IN	denotes	by
T1053	3080-3091	NN	denotes	interaction
T1054	3092-3096	IN	denotes	with
T1055	3097-3100	CC	denotes	and
T1056	3101-3111	NN	denotes	metabolism
T1057	3115-3126	NNS	denotes	xenobiotics
T1058	3112-3114	IN	denotes	of
T1059	3127-3131	JJ	denotes	such
T1060	3132-3134	IN	denotes	as
T1061	3135-3144	NN	denotes	pollution
T1062	3145-3148	CC	denotes	and
T1063	3149-3158	NN	denotes	cigarette
T1064	3159-3164	NN	denotes	smoke
T1065	3165-3166	-LRB-	denotes	[
T1066	3166-3167	CD	denotes	4
T1067	3167-3168	SYM	denotes	-
T1068	3168-3169	CD	denotes	7
T1069	3169-3170	-RRB-	denotes	]
T1070	3171-3173	RB	denotes	as
T1071	3179-3181	IN	denotes	as
T1072	3174-3178	RB	denotes	well
T1073	3182-3187	DT	denotes	those
T1074	3188-3196	VBN	denotes	produced
T1075	3197-3199	IN	denotes	by
T1076	3200-3206	JJ	denotes	normal
T1077	3216-3226	NN	denotes	metabolism
T1078	3207-3215	JJ	denotes	cellular
T1079	3226-3227	.	denotes	.
T1080	3227-3424	sentence	denotes	Reactive oxygen species cause many damaging reactions including denaturation of proteins, cross-linking of lipids and proteins and modification of nucleic acid bases, which can lead to cancer [7].
T1081	3228-3236	JJ	denotes	Reactive
T1082	3244-3251	NNS	denotes	species
T1083	3237-3243	NN	denotes	oxygen
T1084	3252-3257	VBP	denotes	cause
T1085	3258-3262	JJ	denotes	many
T1086	3272-3281	NNS	denotes	reactions
T1087	3263-3271	VBG	denotes	damaging
T1088	3282-3291	VBG	denotes	including
T1089	3292-3304	NN	denotes	denaturation
T1090	3305-3307	IN	denotes	of
T1091	3308-3316	NN	denotes	proteins
T1092	3316-3318	,	denotes	,
T1093	3318-3331	NN	denotes	cross-linking
T1094	3332-3334	IN	denotes	of
T1095	3335-3341	NNS	denotes	lipids
T1096	3342-3345	CC	denotes	and
T1097	3346-3354	NN	denotes	proteins
T1098	3355-3358	CC	denotes	and
T1099	3359-3371	NN	denotes	modification
T1100	3372-3374	IN	denotes	of
T1101	3375-3382	JJ	denotes	nucleic
T1102	3383-3387	NN	denotes	acid
T1103	3388-3393	NNS	denotes	bases
T1104	3393-3395	,	denotes	,
T1105	3395-3400	WDT	denotes	which
T1106	3405-3409	VB	denotes	lead
T1107	3401-3404	MD	denotes	can
T1108	3410-3412	IN	denotes	to
T1109	3413-3419	NN	denotes	cancer
T1110	3420-3421	-LRB-	denotes	[
T1111	3421-3422	CD	denotes	7
T1112	3422-3423	-RRB-	denotes	]
T1113	3423-3424	.	denotes	.
T1114	3424-3602	sentence	denotes	DNA repair enzymes repair the frequent damage to DNA caused by oxidant stress as well as other stresses, including bulky adducts derived from carcinogens in cigarette smoke [8].
T1115	3425-3428	NN	denotes	DNA
T1116	3429-3435	NN	denotes	repair
T1117	3436-3443	NNS	denotes	enzymes
T1118	3444-3450	VBP	denotes	repair
T1119	3451-3454	DT	denotes	the
T1120	3464-3470	NN	denotes	damage
T1121	3455-3463	JJ	denotes	frequent
T1122	3471-3473	IN	denotes	to
T1123	3474-3477	NN	denotes	DNA
T1124	3478-3484	VBN	denotes	caused
T1125	3485-3487	IN	denotes	by
T1126	3488-3495	NN	denotes	oxidant
T1127	3496-3502	NN	denotes	stress
T1128	3503-3505	RB	denotes	as
T1129	3511-3513	IN	denotes	as
T1130	3506-3510	RB	denotes	well
T1131	3514-3519	JJ	denotes	other
T1132	3520-3528	NNS	denotes	stresses
T1133	3528-3530	,	denotes	,
T1134	3530-3539	VBG	denotes	including
T1135	3540-3545	JJ	denotes	bulky
T1136	3546-3553	NNS	denotes	adducts
T1137	3554-3561	VBN	denotes	derived
T1138	3562-3566	IN	denotes	from
T1139	3567-3578	NNS	denotes	carcinogens
T1140	3579-3581	IN	denotes	in
T1141	3582-3591	NN	denotes	cigarette
T1142	3592-3597	NN	denotes	smoke
T1143	3598-3599	-LRB-	denotes	[
T1144	3599-3600	CD	denotes	8
T1145	3600-3601	-RRB-	denotes	]
T1146	3601-3602	.	denotes	.
T1147	3602-3862	sentence	denotes	We previously reported that an interactive transcript abundance index comprising antioxidant genes was lower in NBEC of BC individuals compared to non-BC individuals, suggesting that BC individuals are selected on the basis of poor antioxidant protection [9].
T1148	3603-3605	PRP	denotes	We
T1149	3617-3625	VBD	denotes	reported
T1150	3606-3616	RB	denotes	previously
T1151	3626-3630	IN	denotes	that
T1152	3702-3705	VBD	denotes	was
T1153	3631-3633	DT	denotes	an
T1154	3667-3672	NN	denotes	index
T1155	3634-3645	JJ	denotes	interactive
T1156	3646-3656	NN	denotes	transcript
T1157	3657-3666	NN	denotes	abundance
T1158	3673-3683	VBG	denotes	comprising
T1159	3684-3695	NN	denotes	antioxidant
T1160	3696-3701	NNS	denotes	genes
T1161	3706-3711	JJR	denotes	lower
T1162	3712-3714	IN	denotes	in
T1163	3715-3719	NN	denotes	NBEC
T1164	3720-3722	IN	denotes	of
T1165	3723-3725	NN	denotes	BC
T1166	3726-3737	NNS	denotes	individuals
T1167	3738-3746	VBN	denotes	compared
T1168	3747-3749	IN	denotes	to
T1169	3750-3756	JJ	denotes	non-BC
T1170	3757-3768	NNS	denotes	individuals
T1171	3768-3770	,	denotes	,
T1172	3770-3780	VBG	denotes	suggesting
T1173	3781-3785	IN	denotes	that
T1174	3805-3813	VBN	denotes	selected
T1175	3786-3788	NN	denotes	BC
T1176	3789-3800	NNS	denotes	individuals
T1177	3801-3804	VBP	denotes	are
T1178	3814-3816	IN	denotes	on
T1179	3817-3820	DT	denotes	the
T1180	3821-3826	NN	denotes	basis
T1181	3827-3829	IN	denotes	of
T1182	3830-3834	JJ	denotes	poor
T1183	3847-3857	NN	denotes	protection
T1184	3835-3846	NN	denotes	antioxidant
T1185	3858-3859	-LRB-	denotes	[
T1186	3859-3860	CD	denotes	9
T1187	3860-3861	-RRB-	denotes	]
T1188	3861-3862	.	denotes	.
T1189	3862-4049	sentence	denotes	In that study, there was a tendency towards correlation in transcript abundance between several pairs of antioxidant or DNA repair genes in non-BC individuals, but not in BC individuals.
T1190	3863-3865	IN	denotes	In
T1191	3884-3887	VBD	denotes	was
T1192	3866-3870	DT	denotes	that
T1193	3871-3876	NN	denotes	study
T1194	3876-3878	,	denotes	,
T1195	3878-3883	EX	denotes	there
T1196	3888-3889	DT	denotes	a
T1197	3890-3898	NN	denotes	tendency
T1198	3899-3906	IN	denotes	towards
T1199	3907-3918	NN	denotes	correlation
T1200	3919-3921	IN	denotes	in
T1201	3922-3932	NN	denotes	transcript
T1202	3933-3942	NN	denotes	abundance
T1203	3943-3950	IN	denotes	between
T1204	3951-3958	JJ	denotes	several
T1205	3959-3964	NNS	denotes	pairs
T1206	3965-3967	IN	denotes	of
T1207	3968-3979	NN	denotes	antioxidant
T1208	3994-3999	NNS	denotes	genes
T1209	3980-3982	CC	denotes	or
T1210	3983-3986	NN	denotes	DNA
T1211	3987-3993	NN	denotes	repair
T1212	4000-4002	IN	denotes	in
T1213	4003-4009	JJ	denotes	non-BC
T1214	4010-4021	NNS	denotes	individuals
T1215	4021-4023	,	denotes	,
T1216	4023-4026	CC	denotes	but
T1217	4027-4030	RB	denotes	not
T1218	4031-4033	IN	denotes	in
T1219	4034-4036	NN	denotes	BC
T1220	4037-4048	NNS	denotes	individuals
T1221	4048-4049	.	denotes	.
T1222	4049-4131	sentence	denotes	Gene pairs included in that observation were GSTP1/GPX1, CAT/GPX3, and GPX3/SOD1.
T1223	4050-4054	NN	denotes	Gene
T1224	4055-4060	NNS	denotes	pairs
T1225	4090-4094	VBD	denotes	were
T1226	4061-4069	VBN	denotes	included
T1227	4070-4072	IN	denotes	in
T1228	4073-4077	DT	denotes	that
T1229	4078-4089	NN	denotes	observation
T1230	4095-4100	NN	denotes	GSTP1
T1231	4101-4105	NN	denotes	GPX1
T1232	4100-4101	HYPH	denotes	/
T1233	4105-4107	,	denotes	,
T1234	4107-4110	NN	denotes	CAT
T1235	4111-4115	NN	denotes	GPX3
T1236	4110-4111	HYPH	denotes	/
T1237	4115-4117	,	denotes	,
T1238	4117-4120	CC	denotes	and
T1239	4121-4125	NN	denotes	GPX3
T1240	4126-4130	NN	denotes	SOD1
T1241	4125-4126	HYPH	denotes	/
T1242	4130-4131	.	denotes	.
T1243	4131-4196	sentence	denotes	Correlation is one typical characteristic of co-regulated genes.
T1244	4132-4143	NN	denotes	Correlation
T1245	4144-4146	VBZ	denotes	is
T1246	4147-4150	CD	denotes	one
T1247	4159-4173	NN	denotes	characteristic
T1248	4151-4158	JJ	denotes	typical
T1249	4174-4176	IN	denotes	of
T1250	4177-4189	VBN	denotes	co-regulated
T1251	4190-4195	NNS	denotes	genes
T1252	4195-4196	.	denotes	.
T1253	4196-4300	sentence	denotes	Another is shared transcription factor recognition sites in the regulatory regions of those genes [10].
T1254	4197-4204	DT	denotes	Another
T1255	4205-4207	VBZ	denotes	is
T1256	4208-4214	VBN	denotes	shared
T1257	4248-4253	NNS	denotes	sites
T1258	4215-4228	NN	denotes	transcription
T1259	4229-4235	NN	denotes	factor
T1260	4236-4247	NN	denotes	recognition
T1261	4254-4256	IN	denotes	in
T1262	4257-4260	DT	denotes	the
T1263	4272-4279	NNS	denotes	regions
T1264	4261-4271	JJ	denotes	regulatory
T1265	4280-4282	IN	denotes	of
T1266	4283-4288	DT	denotes	those
T1267	4289-4294	NNS	denotes	genes
T1268	4295-4296	-LRB-	denotes	[
T1269	4296-4298	CD	denotes	10
T1270	4298-4299	-RRB-	denotes	]
T1271	4299-4300	.	denotes	.
T1272	4300-4606	sentence	denotes	Based on the above findings, it was hypothesized first, that there is inter-individual variation in regulation of key antioxidant and DNA repair genes by one or more transcription factors and second, that individuals with sub-optimal regulation are selected for development of BC if they smoke cigarettes.
T1273	4301-4306	VBN	denotes	Based
T1274	4337-4349	VBN	denotes	hypothesized
T1275	4307-4309	IN	denotes	on
T1276	4310-4313	DT	denotes	the
T1277	4320-4328	NNS	denotes	findings
T1278	4314-4319	JJ	denotes	above
T1279	4328-4330	,	denotes	,
T1280	4330-4332	PRP	denotes	it
T1281	4333-4336	VBD	denotes	was
T1282	4350-4355	RB	denotes	first
T1283	4368-4370	VBZ	denotes	is
T1284	4355-4357	,	denotes	,
T1285	4357-4361	IN	denotes	that
T1286	4362-4367	EX	denotes	there
T1287	4371-4387	JJ	denotes	inter-individual
T1288	4388-4397	NN	denotes	variation
T1289	4398-4400	IN	denotes	in
T1290	4401-4411	NN	denotes	regulation
T1291	4412-4414	IN	denotes	of
T1292	4415-4418	JJ	denotes	key
T1293	4446-4451	NNS	denotes	genes
T1294	4419-4430	NN	denotes	antioxidant
T1295	4431-4434	CC	denotes	and
T1296	4435-4438	NN	denotes	DNA
T1297	4439-4445	NN	denotes	repair
T1298	4452-4454	IN	denotes	by
T1299	4455-4458	CD	denotes	one
T1300	4481-4488	NNS	denotes	factors
T1301	4459-4461	CC	denotes	or
T1302	4462-4466	JJR	denotes	more
T1303	4467-4480	NN	denotes	transcription
T1304	4489-4492	CC	denotes	and
T1305	4493-4499	RB	denotes	second
T1306	4550-4558	VBN	denotes	selected
T1307	4499-4501	,	denotes	,
T1308	4501-4505	IN	denotes	that
T1309	4506-4517	NNS	denotes	individuals
T1310	4518-4522	IN	denotes	with
T1311	4523-4534	JJ	denotes	sub-optimal
T1312	4535-4545	NN	denotes	regulation
T1313	4546-4549	VBP	denotes	are
T1314	4559-4562	IN	denotes	for
T1315	4563-4574	NN	denotes	development
T1316	4575-4577	IN	denotes	of
T1317	4578-4580	NN	denotes	BC
T1318	4581-4583	IN	denotes	if
T1319	4589-4594	VBP	denotes	smoke
T1320	4584-4588	PRP	denotes	they
T1321	4595-4605	NNS	denotes	cigarettes
T1322	4605-4606	.	denotes	.
T1323	4606-4919	sentence	denotes	To test these hypotheses, transcription factor recognition sites common to the regulatory regions of the above correlated gene pairs were identified through in silico DNA sequence analysis, and their transcript abundance measured simultaneously with an expanded group of ten antioxidant and six DNA repair genes.
T1324	4607-4609	TO	denotes	To
T1325	4610-4614	VB	denotes	test
T1326	4745-4755	VBN	denotes	identified
T1327	4615-4620	DT	denotes	these
T1328	4621-4631	NNS	denotes	hypotheses
T1329	4631-4633	,	denotes	,
T1330	4633-4646	NN	denotes	transcription
T1331	4647-4653	NN	denotes	factor
T1332	4666-4671	NNS	denotes	sites
T1333	4654-4665	NN	denotes	recognition
T1334	4672-4678	JJ	denotes	common
T1335	4679-4681	IN	denotes	to
T1336	4682-4685	DT	denotes	the
T1337	4697-4704	NNS	denotes	regions
T1338	4686-4696	JJ	denotes	regulatory
T1339	4705-4707	IN	denotes	of
T1340	4708-4711	DT	denotes	the
T1341	4734-4739	NNS	denotes	pairs
T1342	4712-4717	JJ	denotes	above
T1343	4718-4728	VBN	denotes	correlated
T1344	4729-4733	NN	denotes	gene
T1345	4740-4744	VBD	denotes	were
T1346	4756-4763	IN	denotes	through
T1347	4764-4766	FW	denotes	in
T1348	4767-4773	FW	denotes	silico
T1349	4787-4795	NN	denotes	analysis
T1350	4774-4777	NN	denotes	DNA
T1351	4778-4786	NN	denotes	sequence
T1352	4795-4797	,	denotes	,
T1353	4797-4800	CC	denotes	and
T1354	4801-4806	PRP$	denotes	their
T1355	4818-4827	NN	denotes	abundance
T1356	4807-4817	NN	denotes	transcript
T1357	4828-4836	VBN	denotes	measured
T1358	4837-4851	RB	denotes	simultaneously
T1359	4852-4856	IN	denotes	with
T1360	4857-4859	DT	denotes	an
T1361	4869-4874	NN	denotes	group
T1362	4860-4868	VBN	denotes	expanded
T1363	4875-4877	IN	denotes	of
T1364	4878-4881	CD	denotes	ten
T1365	4882-4893	NN	denotes	antioxidant
T1366	4913-4918	NNS	denotes	genes
T1367	4894-4897	CC	denotes	and
T1368	4898-4901	CD	denotes	six
T1369	4906-4912	NN	denotes	repair
T1370	4902-4905	NN	denotes	DNA
T1371	4918-4919	.	denotes	.
T1390	4930-4934	NN	denotes	NBEC
T1391	4935-4941	NN	denotes	sample
T1392	4942-4953	NN	denotes	procurement
T1393	4953-5129	sentence	denotes	Brush biopsy samples of normal bronchial epithelium were obtained for research studies at the time of diagnostic bronchoscopy according to previously described methods [9,11].
T1394	4954-4959	NN	denotes	Brush
T1395	4967-4974	NNS	denotes	samples
T1396	4960-4966	NN	denotes	biopsy
T1397	5011-5019	VBN	denotes	obtained
T1398	4975-4977	IN	denotes	of
T1399	4978-4984	JJ	denotes	normal
T1400	4995-5005	NN	denotes	epithelium
T1401	4985-4994	JJ	denotes	bronchial
T1402	5006-5010	VBD	denotes	were
T1403	5020-5023	IN	denotes	for
T1404	5024-5032	NN	denotes	research
T1405	5033-5040	NNS	denotes	studies
T1406	5041-5043	IN	denotes	at
T1407	5044-5047	DT	denotes	the
T1408	5048-5052	NN	denotes	time
T1409	5053-5055	IN	denotes	of
T1410	5056-5066	JJ	denotes	diagnostic
T1411	5067-5079	NN	denotes	bronchoscopy
T1412	5080-5089	VBG	denotes	according
T1413	5090-5092	IN	denotes	to
T1414	5093-5103	RB	denotes	previously
T1415	5104-5113	VBN	denotes	described
T1416	5114-5121	NNS	denotes	methods
T1417	5122-5123	-LRB-	denotes	[
T1418	5125-5127	CD	denotes	11
T1419	5123-5124	CD	denotes	9
T1420	5124-5125	,	denotes	,
T1421	5127-5128	-RRB-	denotes	]
T1422	5128-5129	.	denotes	.
T1423	5129-5255	sentence	denotes	Normal bronchial epithelium in the lung not involved with cancer was brushed prior to biopsy of the suspected cancerous area.
T1424	5130-5136	JJ	denotes	Normal
T1425	5147-5157	NN	denotes	epithelium
T1426	5137-5146	JJ	denotes	bronchial
T1427	5199-5206	VBN	denotes	brushed
T1428	5158-5160	IN	denotes	in
T1429	5161-5164	DT	denotes	the
T1430	5165-5169	NN	denotes	lung
T1431	5170-5173	RB	denotes	not
T1432	5174-5182	VBN	denotes	involved
T1433	5183-5187	IN	denotes	with
T1434	5188-5194	NN	denotes	cancer
T1435	5195-5198	VBD	denotes	was
T1436	5207-5212	JJ	denotes	prior
T1437	5213-5215	IN	denotes	to
T1438	5216-5222	NN	denotes	biopsy
T1439	5223-5225	IN	denotes	of
T1440	5226-5229	DT	denotes	the
T1441	5250-5254	NN	denotes	area
T1442	5230-5239	VBN	denotes	suspected
T1443	5240-5249	JJ	denotes	cancerous
T1444	5254-5255	.	denotes	.
T1445	5255-5388	sentence	denotes	Samples were collected in a manner satisfying all requirements of the Institutional Review Board for the Medical University of Ohio.
T1446	5256-5263	NNS	denotes	Samples
T1447	5269-5278	VBN	denotes	collected
T1448	5264-5268	VBD	denotes	were
T1449	5279-5281	IN	denotes	in
T1450	5282-5283	DT	denotes	a
T1451	5284-5290	NN	denotes	manner
T1452	5291-5301	VBG	denotes	satisfying
T1453	5302-5305	DT	denotes	all
T1454	5306-5318	NNS	denotes	requirements
T1455	5319-5321	IN	denotes	of
T1456	5322-5325	DT	denotes	the
T1457	5347-5352	NNP	denotes	Board
T1458	5326-5339	NNP	denotes	Institutional
T1459	5340-5346	NNP	denotes	Review
T1460	5353-5356	IN	denotes	for
T1461	5357-5360	DT	denotes	the
T1462	5369-5379	NNP	denotes	University
T1463	5361-5368	NNP	denotes	Medical
T1464	5380-5382	IN	denotes	of
T1465	5383-5387	NNP	denotes	Ohio
T1466	5387-5388	.	denotes	.
T1467	5388-5547	sentence	denotes	Each BC diagnosis and subtype identification was determined by histopathological examination in the Department of Pathology at the Medical University of Ohio.
T1468	5389-5393	DT	denotes	Each
T1469	5397-5406	NN	denotes	diagnosis
T1470	5394-5396	NN	denotes	BC
T1471	5438-5448	VBN	denotes	determined
T1472	5407-5410	CC	denotes	and
T1473	5411-5418	NN	denotes	subtype
T1474	5419-5433	NN	denotes	identification
T1475	5434-5437	VBD	denotes	was
T1476	5449-5451	IN	denotes	by
T1477	5452-5469	JJ	denotes	histopathological
T1478	5470-5481	NN	denotes	examination
T1479	5482-5484	IN	denotes	in
T1480	5485-5488	DT	denotes	the
T1481	5489-5499	NNP	denotes	Department
T1482	5500-5502	IN	denotes	of
T1483	5503-5512	NNP	denotes	Pathology
T1484	5513-5515	IN	denotes	at
T1485	5516-5519	DT	denotes	the
T1486	5528-5538	NNP	denotes	University
T1487	5520-5527	NNP	denotes	Medical
T1488	5539-5541	IN	denotes	of
T1489	5542-5546	NNP	denotes	Ohio
T1490	5546-5547	.	denotes	.
T1491	5547-5677	sentence	denotes	NBEC samples from a total of 49 individuals, including 24 non-BC individuals and 25 BC individuals, were evaluated in this study.
T1492	5548-5552	NN	denotes	NBEC
T1493	5553-5560	NNS	denotes	samples
T1494	5653-5662	VBN	denotes	evaluated
T1495	5561-5565	IN	denotes	from
T1496	5566-5567	DT	denotes	a
T1497	5568-5573	NN	denotes	total
T1498	5574-5576	IN	denotes	of
T1499	5577-5579	CD	denotes	49
T1500	5580-5591	NNS	denotes	individuals
T1501	5591-5593	,	denotes	,
T1502	5593-5602	VBG	denotes	including
T1503	5603-5605	CD	denotes	24
T1504	5613-5624	NNS	denotes	individuals
T1505	5606-5612	JJ	denotes	non-BC
T1506	5625-5628	CC	denotes	and
T1507	5629-5631	CD	denotes	25
T1508	5635-5646	NNS	denotes	individuals
T1509	5632-5634	NN	denotes	BC
T1510	5646-5648	,	denotes	,
T1511	5648-5652	VBD	denotes	were
T1512	5663-5665	IN	denotes	in
T1513	5666-5670	DT	denotes	this
T1514	5671-5676	NN	denotes	study
T1515	5676-5677	.	denotes	.
T1516	5677-5757	sentence	denotes	The biographical characteristics of these individuals are presented in Table 1.
T1517	5678-5681	DT	denotes	The
T1518	5695-5710	NNS	denotes	characteristics
T1519	5682-5694	JJ	denotes	biographical
T1520	5736-5745	VBN	denotes	presented
T1521	5711-5713	IN	denotes	of
T1522	5714-5719	DT	denotes	these
T1523	5720-5731	NNS	denotes	individuals
T1524	5732-5735	VBP	denotes	are
T1525	5746-5748	IN	denotes	in
T1526	5749-5754	NN	denotes	Table
T1527	5755-5756	CD	denotes	1
T1528	5756-5757	.	denotes	.
T1605	5759-5769	NN	denotes	Transcript
T1606	5770-5779	NN	denotes	abundance
T1607	5780-5791	NN	denotes	measurement
T1608	5791-5941	sentence	denotes	Total RNA samples extracted from NBEC were reverse transcribed using M-MLV reverse transcriptase and oligo dT primers as previously described [9,11].
T1609	5792-5797	JJ	denotes	Total
T1610	5802-5809	NNS	denotes	samples
T1611	5798-5801	NN	denotes	RNA
T1612	5843-5854	VBN	denotes	transcribed
T1613	5810-5819	VBN	denotes	extracted
T1614	5820-5824	IN	denotes	from
T1615	5825-5829	NN	denotes	NBEC
T1616	5830-5834	VBD	denotes	were
T1617	5835-5842	RB	denotes	reverse
T1618	5855-5860	VBG	denotes	using
T1619	5861-5862	NN	denotes	M
T1620	5863-5866	NN	denotes	MLV
T1621	5862-5863	HYPH	denotes	-
T1622	5875-5888	NN	denotes	transcriptase
T1623	5867-5874	JJ	denotes	reverse
T1624	5889-5892	CC	denotes	and
T1625	5893-5898	NN	denotes	oligo
T1626	5899-5901	NN	denotes	dT
T1627	5902-5909	NNS	denotes	primers
T1628	5910-5912	IN	denotes	as
T1629	5924-5933	VBN	denotes	described
T1630	5913-5923	RB	denotes	previously
T1631	5934-5935	-LRB-	denotes	[
T1632	5937-5939	CD	denotes	11
T1633	5935-5936	CD	denotes	9
T1634	5936-5937	,	denotes	,
T1635	5939-5940	-RRB-	denotes	]
T1636	5940-5941	.	denotes	.
T1637	5941-6033	sentence	denotes	Standardized RT (StaRT)-PCR was used for transcript abundance measurement in these studies.
T1638	5942-5954	VBN	denotes	Standardized
T1639	5955-5957	NN	denotes	RT
T1640	5966-5969	NN	denotes	PCR
T1641	5958-5959	-LRB-	denotes	(
T1642	5959-5964	NN	denotes	StaRT
T1643	5964-5965	-RRB-	denotes	)
T1644	5965-5966	HYPH	denotes	-
T1645	5974-5978	VBN	denotes	used
T1646	5970-5973	VBD	denotes	was
T1647	5979-5982	IN	denotes	for
T1648	5983-5993	NN	denotes	transcript
T1649	5994-6003	NN	denotes	abundance
T1650	6004-6015	NN	denotes	measurement
T1651	6016-6018	IN	denotes	in
T1652	6019-6024	DT	denotes	these
T1653	6025-6032	NNS	denotes	studies
T1654	6032-6033	.	denotes	.
T1655	6033-6177	sentence	denotes	With StaRT-PCR, an internal standard for each gene within a standardized mixture of internal standards (SMIS) is included in each PCR reaction.
T1656	6034-6038	IN	denotes	With
T1657	6147-6155	VBN	denotes	included
T1658	6039-6044	NN	denotes	StaRT
T1659	6045-6048	NN	denotes	PCR
T1660	6044-6045	HYPH	denotes	-
T1661	6048-6050	,	denotes	,
T1662	6050-6052	DT	denotes	an
T1663	6062-6070	NN	denotes	standard
T1664	6053-6061	JJ	denotes	internal
T1665	6071-6074	IN	denotes	for
T1666	6075-6079	DT	denotes	each
T1667	6080-6084	NN	denotes	gene
T1668	6085-6091	IN	denotes	within
T1669	6092-6093	DT	denotes	a
T1670	6107-6114	NN	denotes	mixture
T1671	6094-6106	VBN	denotes	standardized
T1672	6115-6117	IN	denotes	of
T1673	6118-6126	JJ	denotes	internal
T1674	6127-6136	NNS	denotes	standards
T1675	6137-6138	-LRB-	denotes	(
T1676	6138-6142	NN	denotes	SMIS
T1677	6142-6143	-RRB-	denotes	)
T1678	6144-6146	VBZ	denotes	is
T1679	6156-6158	IN	denotes	in
T1680	6159-6163	DT	denotes	each
T1681	6168-6176	NN	denotes	reaction
T1682	6164-6167	NN	denotes	PCR
T1683	6176-6177	.	denotes	.
T1684	6177-6422	sentence	denotes	After amplification, products were electrophoresed on an Agilent 2100 Bioanalyzer using DNA Chips with DNA 1000 Kit reagents for visualization according to the manufacturer's protocol (Agilent Technologies Deutschland GmbH, Waldbronn, Germany).
T1685	6178-6183	IN	denotes	After
T1686	6213-6228	VBN	denotes	electrophoresed
T1687	6184-6197	NN	denotes	amplification
T1688	6197-6199	,	denotes	,
T1689	6199-6207	NNS	denotes	products
T1690	6208-6212	VBD	denotes	were
T1691	6229-6231	IN	denotes	on
T1692	6232-6234	DT	denotes	an
T1693	6248-6259	NNP	denotes	Bioanalyzer
T1694	6235-6242	NNP	denotes	Agilent
T1695	6243-6247	CD	denotes	2100
T1696	6260-6265	VBG	denotes	using
T1697	6266-6269	NN	denotes	DNA
T1698	6270-6275	NNS	denotes	Chips
T1699	6276-6280	IN	denotes	with
T1700	6281-6284	NN	denotes	DNA
T1701	6290-6293	NN	denotes	Kit
T1702	6285-6289	CD	denotes	1000
T1703	6294-6302	NNS	denotes	reagents
T1704	6303-6306	IN	denotes	for
T1705	6307-6320	NN	denotes	visualization
T1706	6321-6330	VBG	denotes	according
T1707	6331-6333	IN	denotes	to
T1708	6334-6337	DT	denotes	the
T1709	6338-6350	NN	denotes	manufacturer
T1710	6353-6361	NN	denotes	protocol
T1711	6350-6352	POS	denotes	's
T1712	6362-6363	-LRB-	denotes	(
T1713	6396-6400	NNP	denotes	GmbH
T1714	6363-6370	NNP	denotes	Agilent
T1715	6371-6383	NNP	denotes	Technologies
T1716	6384-6395	NNP	denotes	Deutschland
T1717	6400-6402	,	denotes	,
T1718	6402-6411	NNP	denotes	Waldbronn
T1719	6411-6413	,	denotes	,
T1720	6413-6420	NNP	denotes	Germany
T1721	6420-6421	-RRB-	denotes	)
T1722	6421-6422	.	denotes	.
T1723	6422-6495	sentence	denotes	The StaRT-PCR technology is licensed to Gene Express, Inc. (Toledo, OH).
T1724	6423-6426	DT	denotes	The
T1725	6437-6447	NN	denotes	technology
T1726	6427-6432	NN	denotes	StaRT
T1727	6433-6436	NN	denotes	PCR
T1728	6432-6433	HYPH	denotes	-
T1729	6451-6459	VBN	denotes	licensed
T1730	6448-6450	VBZ	denotes	is
T1731	6460-6462	IN	denotes	to
T1732	6463-6467	NNP	denotes	Gene
T1733	6468-6475	NNP	denotes	Express
T1734	6475-6477	,	denotes	,
T1735	6477-6481	NNP	denotes	Inc.
T1736	6482-6483	-LRB-	denotes	(
T1737	6483-6489	NNP	denotes	Toledo
T1738	6489-6491	,	denotes	,
T1739	6491-6493	NNP	denotes	OH
T1740	6493-6494	-RRB-	denotes	)
T1741	6494-6495	.	denotes	.
T1742	6495-6604	sentence	denotes	Many of the reagents are available commercially and were obtained through Gene Express, Inc. for this study.
T1743	6496-6500	JJ	denotes	Many
T1744	6517-6520	VBP	denotes	are
T1745	6501-6503	IN	denotes	of
T1746	6504-6507	DT	denotes	the
T1747	6508-6516	NNS	denotes	reagents
T1748	6521-6530	JJ	denotes	available
T1749	6531-6543	RB	denotes	commercially
T1750	6544-6547	CC	denotes	and
T1751	6548-6552	VBD	denotes	were
T1752	6553-6561	VBN	denotes	obtained
T1753	6562-6569	IN	denotes	through
T1754	6570-6574	NNP	denotes	Gene
T1755	6575-6582	NNP	denotes	Express
T1756	6582-6584	,	denotes	,
T1757	6584-6588	NNP	denotes	Inc.
T1758	6589-6592	IN	denotes	for
T1759	6593-6597	DT	denotes	this
T1760	6598-6603	NN	denotes	study
T1761	6603-6604	.	denotes	.
T1762	6604-6785	sentence	denotes	StaRT-PCR reagents for each of the measured genes that were not commercially available, including primers and SMIS, were prepared according to previously described methods [11,12].
T1763	6605-6610	NN	denotes	StaRT
T1764	6611-6614	NN	denotes	PCR
T1765	6610-6611	HYPH	denotes	-
T1766	6615-6623	NNS	denotes	reagents
T1767	6726-6734	VBN	denotes	prepared
T1768	6624-6627	IN	denotes	for
T1769	6628-6632	DT	denotes	each
T1770	6633-6635	IN	denotes	of
T1771	6636-6639	DT	denotes	the
T1772	6649-6654	NNS	denotes	genes
T1773	6640-6648	VBN	denotes	measured
T1774	6655-6659	WDT	denotes	that
T1775	6660-6664	VBD	denotes	were
T1776	6665-6668	RB	denotes	not
T1777	6669-6681	RB	denotes	commercially
T1778	6682-6691	JJ	denotes	available
T1779	6691-6693	,	denotes	,
T1780	6693-6702	VBG	denotes	including
T1781	6703-6710	NNS	denotes	primers
T1782	6711-6714	CC	denotes	and
T1783	6715-6719	NN	denotes	SMIS
T1784	6719-6721	,	denotes	,
T1785	6721-6725	VBD	denotes	were
T1786	6735-6744	VBG	denotes	according
T1787	6745-6747	IN	denotes	to
T1788	6748-6758	RB	denotes	previously
T1789	6759-6768	VBN	denotes	described
T1790	6769-6776	NNS	denotes	methods
T1791	6777-6778	-LRB-	denotes	[
T1792	6781-6783	CD	denotes	12
T1793	6778-6780	CD	denotes	11
T1794	6780-6781	,	denotes	,
T1795	6783-6784	-RRB-	denotes	]
T1796	6784-6785	.	denotes	.
T1797	6785-6846	sentence	denotes	Sequence information for the primers is provided in Table 2.
T1798	6786-6794	NN	denotes	Sequence
T1799	6795-6806	NN	denotes	information
T1800	6826-6834	VBN	denotes	provided
T1801	6807-6810	IN	denotes	for
T1802	6811-6814	DT	denotes	the
T1803	6815-6822	NNS	denotes	primers
T1804	6823-6825	VBZ	denotes	is
T1805	6835-6837	IN	denotes	in
T1806	6838-6843	NN	denotes	Table
T1807	6844-6845	CD	denotes	2
T1808	6845-6846	.	denotes	.
T1809	6846-7142	sentence	denotes	Including an internal standard within a SMIS in each measurement controls for all known sources of variation during PCR, including inhibitors in samples, and generates virtually-multiplexed transcript abundance data that are directly comparable across multiple experiments and institutions [13].
T1810	6847-6856	VBG	denotes	Including
T1811	6912-6920	VBZ	denotes	controls
T1812	6857-6859	DT	denotes	an
T1813	6869-6877	NN	denotes	standard
T1814	6860-6868	JJ	denotes	internal
T1815	6878-6884	IN	denotes	within
T1816	6885-6886	DT	denotes	a
T1817	6887-6891	NN	denotes	SMIS
T1818	6892-6894	IN	denotes	in
T1819	6895-6899	DT	denotes	each
T1820	6900-6911	NN	denotes	measurement
T1821	6921-6924	IN	denotes	for
T1822	6925-6928	DT	denotes	all
T1823	6935-6942	NNS	denotes	sources
T1824	6929-6934	JJ	denotes	known
T1825	6943-6945	IN	denotes	of
T1826	6946-6955	NN	denotes	variation
T1827	6956-6962	IN	denotes	during
T1828	6963-6966	NN	denotes	PCR
T1829	6966-6968	,	denotes	,
T1830	6968-6977	VBG	denotes	including
T1831	6978-6988	NNS	denotes	inhibitors
T1832	6989-6991	IN	denotes	in
T1833	6992-6999	NNS	denotes	samples
T1834	6999-7001	,	denotes	,
T1835	7001-7004	CC	denotes	and
T1836	7005-7014	VBZ	denotes	generates
T1837	7015-7024	RB	denotes	virtually
T1838	7025-7036	VBN	denotes	multiplexed
T1839	7024-7025	HYPH	denotes	-
T1840	7058-7062	NNS	denotes	data
T1841	7037-7047	NN	denotes	transcript
T1842	7048-7057	NN	denotes	abundance
T1843	7063-7067	WDT	denotes	that
T1844	7068-7071	VBP	denotes	are
T1845	7072-7080	RB	denotes	directly
T1846	7081-7091	JJ	denotes	comparable
T1847	7092-7098	IN	denotes	across
T1848	7099-7107	JJ	denotes	multiple
T1849	7108-7119	NNS	denotes	experiments
T1850	7120-7123	CC	denotes	and
T1851	7124-7136	NNS	denotes	institutions
T1852	7137-7138	-LRB-	denotes	[
T1853	7138-7140	CD	denotes	13
T1854	7140-7141	-RRB-	denotes	]
T1855	7141-7142	.	denotes	.
T1856	7142-7306	sentence	denotes	The performance characteristics of StaRT-PCR are superior to other forms of commercially available quantitative PCR technology in the areas critical to this study.
T1857	7143-7146	DT	denotes	The
T1858	7159-7174	NNS	denotes	characteristics
T1859	7147-7158	NN	denotes	performance
T1860	7188-7191	VBP	denotes	are
T1861	7175-7177	IN	denotes	of
T1862	7178-7183	NN	denotes	StaRT
T1863	7184-7187	NN	denotes	PCR
T1864	7183-7184	HYPH	denotes	-
T1865	7192-7200	JJ	denotes	superior
T1866	7201-7203	IN	denotes	to
T1867	7204-7209	JJ	denotes	other
T1868	7210-7215	NNS	denotes	forms
T1869	7216-7218	IN	denotes	of
T1870	7219-7231	RB	denotes	commercially
T1871	7232-7241	JJ	denotes	available
T1872	7259-7269	NN	denotes	technology
T1873	7242-7254	JJ	denotes	quantitative
T1874	7255-7258	NN	denotes	PCR
T1875	7270-7272	IN	denotes	in
T1876	7273-7276	DT	denotes	the
T1877	7277-7282	NNS	denotes	areas
T1878	7283-7291	JJ	denotes	critical
T1879	7292-7294	IN	denotes	to
T1880	7295-7299	DT	denotes	this
T1881	7300-7305	NN	denotes	study
T1882	7305-7306	.	denotes	.
T1883	7306-7532	sentence	denotes	With respect to these studies, the key property of a quantitative PCR method is not whether the PCR products are measured kinetically or at endpoint, but rather whether there are internal standards in each measurement or not.
T1884	7307-7311	IN	denotes	With
T1885	7384-7386	VBZ	denotes	is
T1886	7312-7319	NN	denotes	respect
T1887	7320-7322	IN	denotes	to
T1888	7323-7328	DT	denotes	these
T1889	7329-7336	NNS	denotes	studies
T1890	7336-7338	,	denotes	,
T1891	7338-7341	DT	denotes	the
T1892	7346-7354	NN	denotes	property
T1893	7342-7345	JJ	denotes	key
T1894	7355-7357	IN	denotes	of
T1895	7358-7359	DT	denotes	a
T1896	7377-7383	NN	denotes	method
T1897	7360-7372	JJ	denotes	quantitative
T1898	7373-7376	NN	denotes	PCR
T1899	7387-7390	RB	denotes	not
T1900	7391-7398	IN	denotes	whether
T1901	7420-7428	VBN	denotes	measured
T1902	7399-7402	DT	denotes	the
T1903	7407-7415	NNS	denotes	products
T1904	7403-7406	NN	denotes	PCR
T1905	7416-7419	VBP	denotes	are
T1906	7429-7440	RB	denotes	kinetically
T1907	7444-7446	IN	denotes	at
T1908	7441-7443	CC	denotes	or
T1909	7447-7455	NN	denotes	endpoint
T1910	7455-7457	,	denotes	,
T1911	7457-7460	CC	denotes	but
T1912	7461-7467	RB	denotes	rather
T1913	7468-7475	IN	denotes	whether
T1914	7482-7485	VBP	denotes	are
T1915	7476-7481	EX	denotes	there
T1916	7486-7494	JJ	denotes	internal
T1917	7495-7504	NNS	denotes	standards
T1918	7505-7507	IN	denotes	in
T1919	7508-7512	DT	denotes	each
T1920	7513-7524	NN	denotes	measurement
T1921	7525-7527	CC	denotes	or
T1922	7528-7531	RB	denotes	not
T1923	7531-7532	.	denotes	.
T1924	7532-7728	sentence	denotes	The overall performance characteristics of StaRT-PCR, including extensive validation of the method in independent laboratories have been presented in several recent articles and chapters [13-15].
T1925	7533-7536	DT	denotes	The
T1926	7557-7572	NNS	denotes	characteristics
T1927	7537-7544	JJ	denotes	overall
T1928	7545-7556	NN	denotes	performance
T1929	7670-7679	VBN	denotes	presented
T1930	7573-7575	IN	denotes	of
T1931	7576-7581	NN	denotes	StaRT
T1932	7582-7585	NN	denotes	PCR
T1933	7581-7582	HYPH	denotes	-
T1934	7585-7587	,	denotes	,
T1935	7587-7596	VBG	denotes	including
T1936	7597-7606	JJ	denotes	extensive
T1937	7607-7617	NN	denotes	validation
T1938	7618-7620	IN	denotes	of
T1939	7621-7624	DT	denotes	the
T1940	7625-7631	NN	denotes	method
T1941	7632-7634	IN	denotes	in
T1942	7635-7646	JJ	denotes	independent
T1943	7647-7659	NNS	denotes	laboratories
T1944	7660-7664	VBP	denotes	have
T1945	7665-7669	VBN	denotes	been
T1946	7680-7682	IN	denotes	in
T1947	7683-7690	JJ	denotes	several
T1948	7698-7706	NNS	denotes	articles
T1949	7691-7697	JJ	denotes	recent
T1950	7707-7710	CC	denotes	and
T1951	7711-7719	NNS	denotes	chapters
T1952	7720-7721	-LRB-	denotes	[
T1953	7721-7723	CD	denotes	13
T1954	7723-7724	SYM	denotes	-
T1955	7724-7726	CD	denotes	15
T1956	7726-7727	-RRB-	denotes	]
T1957	7727-7728	.	denotes	.
T1958	7728-8008	sentence	denotes	With respect to the genes measured in this study, for each gene the StaRT-PCR reagents had lower detection threshold of less than 10 molecules, linear dynamic range of more than six orders of magnitude (less than 10 to over 107 molecules), and signal-to-analyte response of 100%.
T1959	7729-7733	IN	denotes	With
T1960	7816-7819	VBD	denotes	had
T1961	7734-7741	NN	denotes	respect
T1962	7742-7744	IN	denotes	to
T1963	7745-7748	DT	denotes	the
T1964	7749-7754	NNS	denotes	genes
T1965	7755-7763	VBN	denotes	measured
T1966	7764-7766	IN	denotes	in
T1967	7767-7771	DT	denotes	this
T1968	7772-7777	NN	denotes	study
T1969	7777-7779	,	denotes	,
T1970	7779-7782	IN	denotes	for
T1971	7783-7787	DT	denotes	each
T1972	7788-7792	NN	denotes	gene
T1973	7793-7796	DT	denotes	the
T1974	7807-7815	NNS	denotes	reagents
T1975	7797-7802	NN	denotes	StaRT
T1976	7803-7806	NN	denotes	PCR
T1977	7802-7803	HYPH	denotes	-
T1978	7820-7825	JJR	denotes	lower
T1979	7836-7845	NN	denotes	threshold
T1980	7826-7835	NN	denotes	detection
T1981	7846-7848	IN	denotes	of
T1982	7849-7853	JJR	denotes	less
T1983	7859-7861	CD	denotes	10
T1984	7854-7858	IN	denotes	than
T1985	7862-7871	NNS	denotes	molecules
T1986	7871-7873	,	denotes	,
T1987	7873-7879	JJ	denotes	linear
T1988	7888-7893	NN	denotes	range
T1989	7880-7887	JJ	denotes	dynamic
T1990	7894-7896	IN	denotes	of
T1991	7897-7901	JJR	denotes	more
T1992	7907-7910	CD	denotes	six
T1993	7902-7906	IN	denotes	than
T1994	7911-7917	NNS	denotes	orders
T1995	7918-7920	IN	denotes	of
T1996	7921-7930	NN	denotes	magnitude
T1997	7931-7932	-LRB-	denotes	(
T1998	7942-7944	CD	denotes	10
T1999	7932-7936	JJR	denotes	less
T2000	7937-7941	IN	denotes	than
T2001	7945-7947	IN	denotes	to
T2002	7948-7952	IN	denotes	over
T2003	7953-7956	CD	denotes	107
T2004	7957-7966	NNS	denotes	molecules
T2005	7966-7967	-RRB-	denotes	)
T2006	7967-7969	,	denotes	,
T2007	7969-7972	CC	denotes	and
T2008	7973-7979	NN	denotes	signal
T2009	7991-7999	NN	denotes	response
T2010	7979-7980	HYPH	denotes	-
T2011	7980-7982	IN	denotes	to
T2012	7982-7983	HYPH	denotes	-
T2013	7983-7990	NN	denotes	analyte
T2014	8000-8002	IN	denotes	of
T2015	8003-8006	CD	denotes	100
T2016	8006-8007	NN	denotes	%
T2017	8007-8008	.	denotes	.
T2018	8008-8289	sentence	denotes	In addition, the presence of an internal standard controls for inter-sample variation in presence of PCR inhibitors (which often are gene-specific) and ensures no false negatives (if the PCR fails the internal standard PCR product is not observed and there are no data to report).
T2019	8009-8011	IN	denotes	In
T2020	8059-8067	VBZ	denotes	controls
T2021	8012-8020	NN	denotes	addition
T2022	8020-8022	,	denotes	,
T2023	8022-8025	DT	denotes	the
T2024	8026-8034	NN	denotes	presence
T2025	8035-8037	IN	denotes	of
T2026	8038-8040	DT	denotes	an
T2027	8050-8058	JJ	denotes	standard
T2028	8041-8049	JJ	denotes	internal
T2029	8068-8071	IN	denotes	for
T2030	8072-8084	JJ	denotes	inter-sample
T2031	8085-8094	NN	denotes	variation
T2032	8095-8097	IN	denotes	in
T2033	8098-8106	NN	denotes	presence
T2034	8107-8109	IN	denotes	of
T2035	8110-8113	NN	denotes	PCR
T2036	8114-8124	NNS	denotes	inhibitors
T2037	8125-8126	-LRB-	denotes	(
T2038	8126-8131	WDT	denotes	which
T2039	8138-8141	VBP	denotes	are
T2040	8132-8137	RB	denotes	often
T2041	8142-8146	NN	denotes	gene
T2042	8147-8155	JJ	denotes	specific
T2043	8146-8147	HYPH	denotes	-
T2044	8155-8156	-RRB-	denotes	)
T2045	8157-8160	CC	denotes	and
T2046	8161-8168	VBZ	denotes	ensures
T2047	8169-8171	DT	denotes	no
T2048	8178-8187	NNS	denotes	negatives
T2049	8172-8177	JJ	denotes	false
T2050	8188-8189	-LRB-	denotes	(
T2051	8247-8255	VBN	denotes	observed
T2052	8189-8191	IN	denotes	if
T2053	8200-8205	VBZ	denotes	fails
T2054	8192-8195	DT	denotes	the
T2055	8196-8199	NN	denotes	PCR
T2056	8206-8209	DT	denotes	the
T2057	8232-8239	NN	denotes	product
T2058	8210-8218	JJ	denotes	internal
T2059	8219-8227	JJ	denotes	standard
T2060	8228-8231	NN	denotes	PCR
T2061	8240-8242	VBZ	denotes	is
T2062	8243-8246	RB	denotes	not
T2063	8256-8259	CC	denotes	and
T2064	8260-8265	EX	denotes	there
T2065	8266-8269	VBP	denotes	are
T2066	8270-8272	DT	denotes	no
T2067	8273-8277	NNS	denotes	data
T2068	8278-8280	TO	denotes	to
T2069	8281-8287	VB	denotes	report
T2070	8287-8288	-RRB-	denotes	)
T2071	8288-8289	.	denotes	.
T2072	8289-8378	sentence	denotes	False positives are eliminated through use of a control PCR reaction with no cDNA in it.
T2073	8290-8295	JJ	denotes	False
T2074	8296-8305	NNS	denotes	positives
T2075	8310-8320	VBN	denotes	eliminated
T2076	8306-8309	VBP	denotes	are
T2077	8321-8328	IN	denotes	through
T2078	8329-8332	NN	denotes	use
T2079	8333-8335	IN	denotes	of
T2080	8336-8337	DT	denotes	a
T2081	8350-8358	NN	denotes	reaction
T2082	8338-8345	NN	denotes	control
T2083	8346-8349	NN	denotes	PCR
T2084	8359-8363	IN	denotes	with
T2085	8364-8366	DT	denotes	no
T2086	8367-8371	NN	denotes	cDNA
T2087	8372-8374	IN	denotes	in
T2088	8375-8377	PRP	denotes	it
T2089	8377-8378	.	denotes	.
T2162	8380-8391	JJ	denotes	Statistical
T2163	8392-8400	NN	denotes	analysis
T2164	8400-8672	sentence	denotes	More than 6,000 transcript abundance measurements were conducted in multiple experiments over two years to assess the six transcription factors and sixteen antioxidant and DNA repair genes in NBEC samples from 49 individuals (24 non-BC individuals and 25 BC individuals).
T2165	8401-8405	JJR	denotes	More
T2166	8411-8416	CD	denotes	6,000
T2167	8406-8410	IN	denotes	than
T2168	8438-8450	NNS	denotes	measurements
T2169	8417-8427	NN	denotes	transcript
T2170	8428-8437	NN	denotes	abundance
T2171	8456-8465	VBN	denotes	conducted
T2172	8451-8455	VBD	denotes	were
T2173	8466-8468	IN	denotes	in
T2174	8469-8477	JJ	denotes	multiple
T2175	8478-8489	NNS	denotes	experiments
T2176	8490-8494	IN	denotes	over
T2177	8495-8498	CD	denotes	two
T2178	8499-8504	NNS	denotes	years
T2179	8505-8507	TO	denotes	to
T2180	8508-8514	VB	denotes	assess
T2181	8515-8518	DT	denotes	the
T2182	8537-8544	NNS	denotes	factors
T2183	8519-8522	CD	denotes	six
T2184	8523-8536	NN	denotes	transcription
T2185	8545-8548	CC	denotes	and
T2186	8549-8556	CD	denotes	sixteen
T2187	8584-8589	NNS	denotes	genes
T2188	8557-8568	NN	denotes	antioxidant
T2189	8569-8572	CC	denotes	and
T2190	8573-8576	NN	denotes	DNA
T2191	8577-8583	NN	denotes	repair
T2192	8590-8592	IN	denotes	in
T2193	8593-8597	NN	denotes	NBEC
T2194	8598-8605	NNS	denotes	samples
T2195	8606-8610	IN	denotes	from
T2196	8611-8613	CD	denotes	49
T2197	8614-8625	NNS	denotes	individuals
T2198	8626-8627	-LRB-	denotes	(
T2199	8637-8648	NNS	denotes	individuals
T2200	8627-8629	CD	denotes	24
T2201	8630-8636	JJ	denotes	non-BC
T2202	8649-8652	CC	denotes	and
T2203	8653-8655	CD	denotes	25
T2204	8659-8670	NNS	denotes	individuals
T2205	8656-8658	NN	denotes	BC
T2206	8670-8671	-RRB-	denotes	)
T2207	8671-8672	.	denotes	.
T2208	8672-8852	sentence	denotes	Correlation of each of the six transcription factors with each of the antioxidant or DNA repair genes was determined by Pearson's correlation following logarithmic transformation.
T2209	8673-8684	NN	denotes	Correlation
T2210	8779-8789	VBN	denotes	determined
T2211	8685-8687	IN	denotes	of
T2212	8688-8692	DT	denotes	each
T2213	8693-8695	IN	denotes	of
T2214	8696-8699	DT	denotes	the
T2215	8718-8725	NNS	denotes	factors
T2216	8700-8703	CD	denotes	six
T2217	8704-8717	NN	denotes	transcription
T2218	8726-8730	IN	denotes	with
T2219	8731-8735	DT	denotes	each
T2220	8736-8738	IN	denotes	of
T2221	8739-8742	DT	denotes	the
T2222	8769-8774	NNS	denotes	genes
T2223	8743-8754	NN	denotes	antioxidant
T2224	8755-8757	CC	denotes	or
T2225	8758-8761	NN	denotes	DNA
T2226	8762-8768	NN	denotes	repair
T2227	8775-8778	VBD	denotes	was
T2228	8790-8792	IN	denotes	by
T2229	8793-8800	NNP	denotes	Pearson
T2230	8803-8814	NN	denotes	correlation
T2231	8800-8802	POS	denotes	's
T2232	8815-8824	VBG	denotes	following
T2233	8825-8836	JJ	denotes	logarithmic
T2234	8837-8851	NN	denotes	transformation
T2235	8851-8852	.	denotes	.
T2236	8852-8972	sentence	denotes	The transformation was necessary due to the wide biological variation in expression of each gene among the individuals.
T2237	8853-8856	DT	denotes	The
T2238	8857-8871	NN	denotes	transformation
T2239	8872-8875	VBD	denotes	was
T2240	8876-8885	JJ	denotes	necessary
T2241	8886-8889	IN	denotes	due
T2242	8890-8892	IN	denotes	to
T2243	8893-8896	DT	denotes	the
T2244	8913-8922	NN	denotes	variation
T2245	8897-8901	JJ	denotes	wide
T2246	8902-8912	JJ	denotes	biological
T2247	8923-8925	IN	denotes	in
T2248	8926-8936	NN	denotes	expression
T2249	8937-8939	IN	denotes	of
T2250	8940-8944	DT	denotes	each
T2251	8945-8949	NN	denotes	gene
T2252	8950-8955	IN	denotes	among
T2253	8956-8959	DT	denotes	the
T2254	8960-8971	NNS	denotes	individuals
T2255	8971-8972	.	denotes	.
T2256	8972-9181	sentence	denotes	Significance level was defined as p < 0.01 following Bonferroni adjustment for multiple comparison, specifically comparison of each of six transcription factors to each of the antioxidant or DNA repair genes.
T2257	8973-8985	NN	denotes	Significance
T2258	8986-8991	NN	denotes	level
T2259	8996-9003	VBN	denotes	defined
T2260	8992-8995	VBD	denotes	was
T2261	9004-9006	IN	denotes	as
T2262	9007-9008	NN	denotes	p
T2263	9009-9010	SYM	denotes	<
T2264	9011-9015	CD	denotes	0.01
T2265	9016-9025	VBG	denotes	following
T2266	9026-9036	NNP	denotes	Bonferroni
T2267	9037-9047	NN	denotes	adjustment
T2268	9048-9051	IN	denotes	for
T2269	9052-9060	JJ	denotes	multiple
T2270	9061-9071	NN	denotes	comparison
T2271	9071-9073	,	denotes	,
T2272	9073-9085	RB	denotes	specifically
T2273	9086-9096	NN	denotes	comparison
T2274	9097-9099	IN	denotes	of
T2275	9100-9104	DT	denotes	each
T2276	9105-9107	IN	denotes	of
T2277	9108-9111	CD	denotes	six
T2278	9126-9133	NNS	denotes	factors
T2279	9112-9125	NN	denotes	transcription
T2280	9134-9136	IN	denotes	to
T2281	9137-9141	DT	denotes	each
T2282	9142-9144	IN	denotes	of
T2283	9145-9148	DT	denotes	the
T2284	9175-9180	NNS	denotes	genes
T2285	9149-9160	NN	denotes	antioxidant
T2286	9161-9163	CC	denotes	or
T2287	9164-9167	NN	denotes	DNA
T2288	9168-9174	NN	denotes	repair
T2289	9180-9181	.	denotes	.
T2290	9181-9311	sentence	denotes	Comparison for significant differences between pairs of correlation coefficients was done by Fisher's Z-transformation test [16].
T2291	9182-9192	NN	denotes	Comparison
T2292	9267-9271	VBN	denotes	done
T2293	9193-9196	IN	denotes	for
T2294	9197-9208	JJ	denotes	significant
T2295	9209-9220	NNS	denotes	differences
T2296	9221-9228	IN	denotes	between
T2297	9229-9234	NNS	denotes	pairs
T2298	9235-9237	IN	denotes	of
T2299	9238-9249	NN	denotes	correlation
T2300	9250-9262	NNS	denotes	coefficients
T2301	9263-9266	VBD	denotes	was
T2302	9272-9274	IN	denotes	by
T2303	9275-9281	NNP	denotes	Fisher
T2304	9301-9305	NN	denotes	test
T2305	9281-9283	POS	denotes	's
T2306	9284-9285	NN	denotes	Z
T2307	9286-9300	NN	denotes	transformation
T2308	9285-9286	HYPH	denotes	-
T2309	9306-9307	-LRB-	denotes	[
T2310	9307-9309	CD	denotes	16
T2311	9309-9310	-RRB-	denotes	]
T2312	9310-9311	.	denotes	.
T2313	9311-9542	sentence	denotes	Analysis of the relationship between virtually-multiplexed transcript abundance data for each gene with age was assessed by Pearson's correlation, with gender by t-test, and with smoking history by ANOVA followed by Duncan's test.
T2314	9312-9320	NN	denotes	Analysis
T2315	9424-9432	VBN	denotes	assessed
T2316	9321-9323	IN	denotes	of
T2317	9324-9327	DT	denotes	the
T2318	9328-9340	NN	denotes	relationship
T2319	9341-9348	IN	denotes	between
T2320	9349-9358	RB	denotes	virtually
T2321	9359-9370	VBN	denotes	multiplexed
T2322	9358-9359	HYPH	denotes	-
T2323	9392-9396	NNS	denotes	data
T2324	9371-9381	NN	denotes	transcript
T2325	9382-9391	NN	denotes	abundance
T2326	9397-9400	IN	denotes	for
T2327	9401-9405	DT	denotes	each
T2328	9406-9410	NN	denotes	gene
T2329	9411-9415	IN	denotes	with
T2330	9416-9419	NN	denotes	age
T2331	9420-9423	VBD	denotes	was
T2332	9433-9435	IN	denotes	by
T2333	9436-9443	NNP	denotes	Pearson
T2334	9446-9457	NN	denotes	correlation
T2335	9443-9445	POS	denotes	's
T2336	9457-9459	,	denotes	,
T2337	9459-9463	IN	denotes	with
T2338	9464-9470	NN	denotes	gender
T2339	9471-9473	IN	denotes	by
T2340	9474-9475	NN	denotes	t
T2341	9476-9480	NN	denotes	test
T2342	9475-9476	HYPH	denotes	-
T2343	9480-9482	,	denotes	,
T2344	9482-9485	CC	denotes	and
T2345	9486-9490	IN	denotes	with
T2346	9491-9498	NN	denotes	smoking
T2347	9499-9506	NN	denotes	history
T2348	9507-9509	IN	denotes	by
T2349	9510-9515	NN	denotes	ANOVA
T2350	9516-9524	VBN	denotes	followed
T2351	9525-9527	IN	denotes	by
T2352	9528-9534	NNP	denotes	Duncan
T2353	9537-9541	NN	denotes	test
T2354	9534-9536	POS	denotes	's
T2355	9541-9542	.	denotes	.
T2482	9544-9557	NN	denotes	Transcription
T2483	9558-9564	NN	denotes	factor
T2484	9577-9581	NN	denotes	site
T2485	9565-9576	NN	denotes	recognition
T2486	9582-9590	NN	denotes	analysis
T2487	9590-9915	sentence	denotes	The El Dorado (Build 35) program from the Genomatix software package was used to locate the correlated genes within the genome and define 1101 base pairs of the promoter regions (1000 base pairs upstream of and 100 base pairs into the transcription start site) for each gene (Genomatix Software GmbH, Munich, Germany, [17]).
T2488	9591-9594	DT	denotes	The
T2489	9616-9623	NN	denotes	program
T2490	9595-9597	NNP	denotes	El
T2491	9598-9604	NNP	denotes	Dorado
T2492	9605-9606	-LRB-	denotes	(
T2493	9606-9611	NNP	denotes	Build
T2494	9612-9614	CD	denotes	35
T2495	9614-9615	-RRB-	denotes	)
T2496	9664-9668	VBN	denotes	used
T2497	9624-9628	IN	denotes	from
T2498	9629-9632	DT	denotes	the
T2499	9652-9659	NN	denotes	package
T2500	9633-9642	NNP	denotes	Genomatix
T2501	9643-9651	NN	denotes	software
T2502	9660-9663	VBD	denotes	was
T2503	9669-9671	TO	denotes	to
T2504	9672-9678	VB	denotes	locate
T2505	9679-9682	DT	denotes	the
T2506	9694-9699	NNS	denotes	genes
T2507	9683-9693	VBN	denotes	correlated
T2508	9700-9706	IN	denotes	within
T2509	9707-9710	DT	denotes	the
T2510	9711-9717	NN	denotes	genome
T2511	9718-9721	CC	denotes	and
T2512	9722-9728	VB	denotes	define
T2513	9729-9733	CD	denotes	1101
T2514	9739-9744	NNS	denotes	pairs
T2515	9734-9738	NN	denotes	base
T2516	9745-9747	IN	denotes	of
T2517	9748-9751	DT	denotes	the
T2518	9761-9768	NNS	denotes	regions
T2519	9752-9760	NN	denotes	promoter
T2520	9769-9770	-LRB-	denotes	(
T2521	9780-9785	NNS	denotes	pairs
T2522	9770-9774	CD	denotes	1000
T2523	9775-9779	NN	denotes	base
T2524	9786-9794	RB	denotes	upstream
T2525	9795-9797	IN	denotes	of
T2526	9798-9801	CC	denotes	and
T2527	9802-9805	CD	denotes	100
T2528	9811-9816	NNS	denotes	pairs
T2529	9806-9810	NN	denotes	base
T2530	9846-9850	NN	denotes	site
T2531	9817-9821	IN	denotes	into
T2532	9822-9825	DT	denotes	the
T2533	9826-9839	NN	denotes	transcription
T2534	9840-9845	NN	denotes	start
T2535	9850-9851	-RRB-	denotes	)
T2536	9852-9855	IN	denotes	for
T2537	9856-9860	DT	denotes	each
T2538	9861-9865	NN	denotes	gene
T2539	9866-9867	-LRB-	denotes	(
T2540	9886-9890	NNP	denotes	GmbH
T2541	9867-9876	NNP	denotes	Genomatix
T2542	9877-9885	NNP	denotes	Software
T2543	9890-9892	,	denotes	,
T2544	9892-9898	NNP	denotes	Munich
T2545	9898-9900	,	denotes	,
T2546	9900-9907	NNP	denotes	Germany
T2547	9907-9909	,	denotes	,
T2548	9909-9910	-LRB-	denotes	[
T2549	9910-9912	CD	denotes	17
T2550	9912-9913	-RRB-	denotes	]
T2551	9913-9914	-RRB-	denotes	)
T2552	9914-9915	.	denotes	.
T2553	9915-10228	sentence	denotes	The 1101 base pair sequences obtained from the El Dorado program then were used as the target sequences for putative transcription factor recognition site identification using the MatInspector Version 4.2 program, which yielded sites for 11 transcription factors (Genomatix Software GmbH, Munich, Germany, [17]).
T2554	9916-9919	DT	denotes	The
T2555	9935-9944	NNS	denotes	sequences
T2556	9920-9924	CD	denotes	1101
T2557	9930-9934	NN	denotes	pair
T2558	9925-9929	NN	denotes	base
T2559	9991-9995	VBN	denotes	used
T2560	9945-9953	VBN	denotes	obtained
T2561	9954-9958	IN	denotes	from
T2562	9959-9962	DT	denotes	the
T2563	9973-9980	NN	denotes	program
T2564	9963-9965	NNP	denotes	El
T2565	9966-9972	NNP	denotes	Dorado
T2566	9981-9985	RB	denotes	then
T2567	9986-9990	VBD	denotes	were
T2568	9996-9998	IN	denotes	as
T2569	9999-10002	DT	denotes	the
T2570	10010-10019	NNS	denotes	sequences
T2571	10003-10009	NN	denotes	target
T2572	10020-10023	IN	denotes	for
T2573	10024-10032	JJ	denotes	putative
T2574	10071-10085	NN	denotes	identification
T2575	10033-10046	NN	denotes	transcription
T2576	10047-10053	NN	denotes	factor
T2577	10066-10070	NN	denotes	site
T2578	10054-10065	NN	denotes	recognition
T2579	10086-10091	VBG	denotes	using
T2580	10092-10095	DT	denotes	the
T2581	10121-10128	NN	denotes	program
T2582	10096-10108	NNP	denotes	MatInspector
T2583	10109-10116	NNP	denotes	Version
T2584	10117-10120	CD	denotes	4.2
T2585	10128-10130	,	denotes	,
T2586	10130-10135	WDT	denotes	which
T2587	10136-10143	VBD	denotes	yielded
T2588	10144-10149	NNS	denotes	sites
T2589	10150-10153	IN	denotes	for
T2590	10154-10156	CD	denotes	11
T2591	10171-10178	NNS	denotes	factors
T2592	10157-10170	NN	denotes	transcription
T2593	10179-10180	-LRB-	denotes	(
T2594	10199-10203	NNP	denotes	GmbH
T2595	10180-10189	NNP	denotes	Genomatix
T2596	10190-10198	NNP	denotes	Software
T2597	10203-10205	,	denotes	,
T2598	10205-10211	NNP	denotes	Munich
T2599	10211-10213	,	denotes	,
T2600	10213-10220	NNP	denotes	Germany
T2601	10220-10222	,	denotes	,
T2602	10222-10223	-LRB-	denotes	[
T2603	10223-10225	CD	denotes	17
T2604	10225-10226	-RRB-	denotes	]
T2605	10226-10227	-RRB-	denotes	)
T2606	10227-10228	.	denotes	.
T2607	10228-10331	sentence	denotes	The parameters used were the standard (0.75) core similarity and the optimized matrix similarity [18].
T2608	10229-10232	DT	denotes	The
T2609	10233-10243	NNS	denotes	parameters
T2610	10249-10253	VBD	denotes	were
T2611	10244-10248	VBN	denotes	used
T2612	10254-10257	DT	denotes	the
T2613	10279-10289	NN	denotes	similarity
T2614	10258-10266	JJ	denotes	standard
T2615	10267-10268	-LRB-	denotes	(
T2616	10268-10272	CD	denotes	0.75
T2617	10272-10273	-RRB-	denotes	)
T2618	10274-10278	NN	denotes	core
T2619	10290-10293	CC	denotes	and
T2620	10294-10297	DT	denotes	the
T2621	10315-10325	NN	denotes	similarity
T2622	10298-10307	VBN	denotes	optimized
T2623	10308-10314	NN	denotes	matrix
T2624	10326-10327	-LRB-	denotes	[
T2625	10327-10329	CD	denotes	18
T2626	10329-10330	-RRB-	denotes	]
T2627	10330-10331	.	denotes	.
T2628	10331-10482	sentence	denotes	StaRT-PCR reagents were optimized for ten of these transcription factors, including CEBPB, CEBPE, CEBPG, E2F1, E2F3, E2F4, E2F5, E2F6, EVI1, and PAX5.
T2629	10332-10337	NN	denotes	StaRT
T2630	10338-10341	NN	denotes	PCR
T2631	10337-10338	HYPH	denotes	-
T2632	10342-10350	NNS	denotes	reagents
T2633	10356-10365	VBN	denotes	optimized
T2634	10351-10355	VBD	denotes	were
T2635	10366-10369	IN	denotes	for
T2636	10370-10373	CD	denotes	ten
T2637	10374-10376	IN	denotes	of
T2638	10377-10382	DT	denotes	these
T2639	10397-10404	NNS	denotes	factors
T2640	10383-10396	NN	denotes	transcription
T2641	10404-10406	,	denotes	,
T2642	10406-10415	VBG	denotes	including
T2643	10416-10421	NN	denotes	CEBPB
T2644	10421-10423	,	denotes	,
T2645	10423-10428	NN	denotes	CEBPE
T2646	10428-10430	,	denotes	,
T2647	10430-10435	NN	denotes	CEBPG
T2648	10435-10437	,	denotes	,
T2649	10437-10441	NN	denotes	E2F1
T2650	10441-10443	,	denotes	,
T2651	10443-10447	NN	denotes	E2F3
T2652	10447-10449	,	denotes	,
T2653	10449-10453	NN	denotes	E2F4
T2654	10453-10455	,	denotes	,
T2655	10455-10459	NN	denotes	E2F5
T2656	10459-10461	,	denotes	,
T2657	10461-10465	NN	denotes	E2F6
T2658	10465-10467	,	denotes	,
T2659	10467-10471	NN	denotes	EVI1
T2660	10471-10473	,	denotes	,
T2661	10473-10476	CC	denotes	and
T2662	10477-10481	NN	denotes	PAX5
T2663	10481-10482	.	denotes	.
T2664	10482-10624	sentence	denotes	Four transcription factors were expressed at low and invariant levels among multiple NBEC samples and were therefore excluded from the study.
T2665	10483-10487	CD	denotes	Four
T2666	10502-10509	NNS	denotes	factors
T2667	10488-10501	NN	denotes	transcription
T2668	10515-10524	VBN	denotes	expressed
T2669	10510-10514	VBD	denotes	were
T2670	10525-10527	IN	denotes	at
T2671	10528-10531	JJ	denotes	low
T2672	10546-10552	NNS	denotes	levels
T2673	10532-10535	CC	denotes	and
T2674	10536-10545	JJ	denotes	invariant
T2675	10553-10558	IN	denotes	among
T2676	10559-10567	JJ	denotes	multiple
T2677	10573-10580	NNS	denotes	samples
T2678	10568-10572	NN	denotes	NBEC
T2679	10581-10584	CC	denotes	and
T2680	10585-10589	VBD	denotes	were
T2681	10600-10608	VBN	denotes	excluded
T2682	10590-10599	RB	denotes	therefore
T2683	10609-10613	IN	denotes	from
T2684	10614-10617	DT	denotes	the
T2685	10618-10623	NN	denotes	study
T2686	10623-10624	.	denotes	.
T2687	10624-10783	sentence	denotes	The remaining six, CEBPB, CEBPG, E2F1, E2F3, E2F6, and EVI, were evaluated for correlation with an expanded group of ten antioxidant and six DNA repair genes.
T2688	10625-10628	DT	denotes	The
T2689	10639-10642	CD	denotes	six
T2690	10629-10638	VBG	denotes	remaining
T2691	10690-10699	VBN	denotes	evaluated
T2692	10642-10644	,	denotes	,
T2693	10644-10649	NN	denotes	CEBPB
T2694	10649-10651	,	denotes	,
T2695	10651-10656	NN	denotes	CEBPG
T2696	10656-10658	,	denotes	,
T2697	10658-10662	NN	denotes	E2F1
T2698	10662-10664	,	denotes	,
T2699	10664-10668	NN	denotes	E2F3
T2700	10668-10670	,	denotes	,
T2701	10670-10674	NN	denotes	E2F6
T2702	10674-10676	,	denotes	,
T2703	10676-10679	CC	denotes	and
T2704	10680-10683	NN	denotes	EVI
T2705	10683-10685	,	denotes	,
T2706	10685-10689	VBD	denotes	were
T2707	10700-10703	IN	denotes	for
T2708	10704-10715	NN	denotes	correlation
T2709	10716-10720	IN	denotes	with
T2710	10721-10723	DT	denotes	an
T2711	10733-10738	NN	denotes	group
T2712	10724-10732	VBN	denotes	expanded
T2713	10739-10741	IN	denotes	of
T2714	10742-10745	CD	denotes	ten
T2715	10746-10757	NN	denotes	antioxidant
T2716	10758-10761	CC	denotes	and
T2717	10762-10765	CD	denotes	six
T2718	10770-10776	NN	denotes	repair
T2719	10766-10769	NN	denotes	DNA
T2720	10777-10782	NNS	denotes	genes
T2721	10782-10783	.	denotes	.
T2747	7015-7024	RB	denotes	virtually
T2748	7025-7036	VBN	denotes	multiplexed
T2749	7024-7025	HYPH	denotes	-
T2750	7058-7062	NNS	denotes	data
T2751	7037-7047	NN	denotes	transcript
T2752	7048-7057	NN	denotes	abundance
T2753	10846-10854	VBN	denotes	obtained
T2754	10841-10845	VBD	denotes	were
T2755	10855-10858	IN	denotes	for
T2756	10859-10863	DT	denotes	each
T2757	10864-10868	NN	denotes	gene
T2758	10869-10871	IN	denotes	in
T2759	10872-10876	DT	denotes	each
T2760	10877-10879	IN	denotes	of
T2761	10880-10883	DT	denotes	the
T2762	10887-10894	NNS	denotes	samples
T2763	10884-10886	CD	denotes	49
T2764	10894-10896	,	denotes	,
T2765	10896-10902	IN	denotes	except
T2766	10903-10906	IN	denotes	for
T2767	10907-10911	NN	denotes	E2F1
T2768	10912-10923	NN	denotes	measurement
T2769	10924-10926	IN	denotes	in
T2770	10927-10933	NN	denotes	sample
T2771	10934-10937	CD	denotes	147
T2772	10938-10939	-LRB-	denotes	(
T2773	10939-10944	NN	denotes	Table
T2774	10945-10946	CD	denotes	3
T2775	10946-10947	-RRB-	denotes	)
T2776	10947-10948	.	denotes	.
T2777	10948-11021	sentence	denotes	A gene-specific inhibitor in sample 147 prevented amplification of E2F1.
T2778	10949-10950	DT	denotes	A
T2779	10965-10974	NN	denotes	inhibitor
T2780	10951-10955	NN	denotes	gene
T2781	10956-10964	JJ	denotes	specific
T2782	10955-10956	HYPH	denotes	-
T2783	10989-10998	VBD	denotes	prevented
T2784	10975-10977	IN	denotes	in
T2785	10978-10984	NN	denotes	sample
T2786	10985-10988	CD	denotes	147
T2787	10999-11012	NN	denotes	amplification
T2788	11013-11015	IN	denotes	of
T2789	11016-11020	NN	denotes	E2F1
T2790	11020-11021	.	denotes	.
T2791	11021-11098	sentence	denotes	Neither the internal standard, nor the native cDNA PCR product was observed.
T2792	11022-11029	CC	denotes	Neither
T2793	11043-11051	NN	denotes	standard
T2794	11030-11033	DT	denotes	the
T2795	11034-11042	JJ	denotes	internal
T2796	11089-11097	VBN	denotes	observed
T2797	11051-11053	,	denotes	,
T2798	11053-11056	CC	denotes	nor
T2799	11057-11060	DT	denotes	the
T2800	11077-11084	NN	denotes	product
T2801	11061-11067	JJ	denotes	native
T2802	11068-11072	NN	denotes	cDNA
T2803	11073-11076	NN	denotes	PCR
T2804	11085-11088	VBD	denotes	was
T2805	11097-11098	.	denotes	.
T2806	11098-11361	sentence	denotes	The presence of gene-specific PCR inhibition was observable in some other samples as reduction in peak heights in internal standard PCR products relative to that expected for the number of internal standard molecules present at the beginning of the PCR reaction.
T2807	11099-11102	DT	denotes	The
T2808	11103-11111	NN	denotes	presence
T2809	11144-11147	VBD	denotes	was
T2810	11112-11114	IN	denotes	of
T2811	11115-11119	NN	denotes	gene
T2812	11120-11128	JJ	denotes	specific
T2813	11119-11120	HYPH	denotes	-
T2814	11133-11143	NN	denotes	inhibition
T2815	11129-11132	NN	denotes	PCR
T2816	11148-11158	JJ	denotes	observable
T2817	11159-11161	IN	denotes	in
T2818	11162-11166	DT	denotes	some
T2819	11173-11180	NNS	denotes	samples
T2820	11167-11172	JJ	denotes	other
T2821	11181-11183	IN	denotes	as
T2822	11184-11193	NN	denotes	reduction
T2823	11194-11196	IN	denotes	in
T2824	11197-11201	NN	denotes	peak
T2825	11202-11209	NNS	denotes	heights
T2826	11210-11212	IN	denotes	in
T2827	11213-11221	JJ	denotes	internal
T2828	11235-11243	NNS	denotes	products
T2829	11222-11230	JJ	denotes	standard
T2830	11231-11234	NN	denotes	PCR
T2831	11244-11252	JJ	denotes	relative
T2832	11253-11255	IN	denotes	to
T2833	11256-11260	DT	denotes	that
T2834	11261-11269	VBN	denotes	expected
T2835	11270-11273	IN	denotes	for
T2836	11274-11277	DT	denotes	the
T2837	11278-11284	NN	denotes	number
T2838	11285-11287	IN	denotes	of
T2839	11288-11296	JJ	denotes	internal
T2840	11306-11315	NNS	denotes	molecules
T2841	11297-11305	JJ	denotes	standard
T2842	11316-11323	JJ	denotes	present
T2843	11324-11326	IN	denotes	at
T2844	11327-11330	DT	denotes	the
T2845	11331-11340	NN	denotes	beginning
T2846	11341-11343	IN	denotes	of
T2847	11344-11347	DT	denotes	the
T2848	11352-11360	NN	denotes	reaction
T2849	11348-11351	NN	denotes	PCR
T2850	11360-11361	.	denotes	.
T2851	11361-11458	sentence	denotes	However, in each such case, the PCR amplification was efficient enough to enable quantification.
T2852	11362-11369	RB	denotes	However
T2853	11412-11415	VBD	denotes	was
T2854	11369-11371	,	denotes	,
T2855	11371-11373	IN	denotes	in
T2856	11374-11378	DT	denotes	each
T2857	11384-11388	NN	denotes	case
T2858	11379-11383	JJ	denotes	such
T2859	11388-11390	,	denotes	,
T2860	11390-11393	DT	denotes	the
T2861	11398-11411	NN	denotes	amplification
T2862	11394-11397	NN	denotes	PCR
T2863	11416-11425	JJ	denotes	efficient
T2864	11426-11432	RB	denotes	enough
T2865	11433-11435	TO	denotes	to
T2866	11436-11442	VB	denotes	enable
T2867	11443-11457	NN	denotes	quantification
T2868	11457-11458	.	denotes	.
T3076	11460-11469	NN	denotes	Bivariate
T3077	11470-11478	NN	denotes	analysis
T3078	11478-11690	sentence	denotes	In non-BC individuals there was significant (p < 0.01) correlation between CEBPG and eight of the 16 antioxidant or DNA repair genes, specifically XRCC1, ERCC5, GSTP1, SOD1, GPX1, ERCC1, CAT and ERCC2 (Table 4).
T3079	11479-11481	IN	denotes	In
T3080	11507-11510	VBD	denotes	was
T3081	11482-11488	JJ	denotes	non-BC
T3082	11489-11500	NNS	denotes	individuals
T3083	11501-11506	EX	denotes	there
T3084	11511-11522	JJ	denotes	significant
T3085	11534-11545	NN	denotes	correlation
T3086	11523-11524	-LRB-	denotes	(
T3087	11528-11532	CD	denotes	0.01
T3088	11524-11525	NN	denotes	p
T3089	11526-11527	SYM	denotes	<
T3090	11532-11533	-RRB-	denotes	)
T3091	11546-11553	IN	denotes	between
T3092	11554-11559	NN	denotes	CEBPG
T3093	11560-11563	CC	denotes	and
T3094	11564-11569	CD	denotes	eight
T3095	11577-11579	CD	denotes	16
T3096	11570-11572	IN	denotes	of
T3097	11573-11576	DT	denotes	the
T3098	11606-11611	NNS	denotes	genes
T3099	11580-11591	NN	denotes	antioxidant
T3100	11592-11594	CC	denotes	or
T3101	11595-11598	NN	denotes	DNA
T3102	11599-11605	NN	denotes	repair
T3103	11611-11613	,	denotes	,
T3104	11613-11625	RB	denotes	specifically
T3105	11626-11631	NN	denotes	XRCC1
T3106	11631-11633	,	denotes	,
T3107	11633-11638	NN	denotes	ERCC5
T3108	11638-11640	,	denotes	,
T3109	11640-11645	NN	denotes	GSTP1
T3110	11645-11647	,	denotes	,
T3111	11647-11651	NN	denotes	SOD1
T3112	11651-11653	,	denotes	,
T3113	11653-11657	NN	denotes	GPX1
T3114	11657-11659	,	denotes	,
T3115	11659-11664	NN	denotes	ERCC1
T3116	11664-11666	,	denotes	,
T3117	11666-11669	NN	denotes	CAT
T3118	11670-11673	CC	denotes	and
T3119	11674-11679	NN	denotes	ERCC2
T3120	11680-11681	-LRB-	denotes	(
T3121	11681-11686	NN	denotes	Table
T3122	11687-11688	CD	denotes	4
T3123	11688-11689	-RRB-	denotes	)
T3124	11689-11690	.	denotes	.
T3125	11690-11803	sentence	denotes	In contrast, in BC individuals samples CEBPG was not correlated with any of the antioxidant or DNA repair genes.
T3126	11691-11693	IN	denotes	In
T3127	11744-11754	VBN	denotes	correlated
T3128	11694-11702	NN	denotes	contrast
T3129	11702-11704	,	denotes	,
T3130	11704-11706	IN	denotes	in
T3131	11707-11709	NN	denotes	BC
T3132	11710-11721	NNS	denotes	individuals
T3133	11722-11729	NNS	denotes	samples
T3134	11730-11735	NN	denotes	CEBPG
T3135	11736-11739	VBD	denotes	was
T3136	11740-11743	RB	denotes	not
T3137	11755-11759	IN	denotes	with
T3138	11760-11763	DT	denotes	any
T3139	11764-11766	IN	denotes	of
T3140	11767-11770	DT	denotes	the
T3141	11797-11802	NNS	denotes	genes
T3142	11771-11782	NN	denotes	antioxidant
T3143	11783-11785	CC	denotes	or
T3144	11786-11789	NN	denotes	DNA
T3145	11790-11796	NN	denotes	repair
T3146	11802-11803	.	denotes	.
T3147	11803-11894	sentence	denotes	These relationships were not observed with any of the other transcription factors studied.
T3148	11804-11809	DT	denotes	These
T3149	11810-11823	NNS	denotes	relationships
T3150	11833-11841	VBN	denotes	observed
T3151	11824-11828	VBD	denotes	were
T3152	11829-11832	RB	denotes	not
T3153	11842-11846	IN	denotes	with
T3154	11847-11850	DT	denotes	any
T3155	11851-11853	IN	denotes	of
T3156	11854-11857	DT	denotes	the
T3157	11878-11885	NNS	denotes	factors
T3158	11858-11863	JJ	denotes	other
T3159	11864-11877	NN	denotes	transcription
T3160	11886-11893	VBN	denotes	studied
T3161	11893-11894	.	denotes	.
T3162	11894-12090	sentence	denotes	For XRCC1, ERCC5, GSTP1, and SOD1 the correlation with CEBPG was significantly lower in BC individuals compared to non-BC individuals and the difference was nearly significant for GPX1 (Fig. 1b).
T3163	11895-11898	IN	denotes	For
T3164	11956-11959	VBD	denotes	was
T3165	11899-11904	NN	denotes	XRCC1
T3166	11904-11906	,	denotes	,
T3167	11906-11911	NN	denotes	ERCC5
T3168	11911-11913	,	denotes	,
T3169	11913-11918	NN	denotes	GSTP1
T3170	11918-11920	,	denotes	,
T3171	11920-11923	CC	denotes	and
T3172	11924-11928	NN	denotes	SOD1
T3173	11929-11932	DT	denotes	the
T3174	11933-11944	NN	denotes	correlation
T3175	11945-11949	IN	denotes	with
T3176	11950-11955	NN	denotes	CEBPG
T3177	11960-11973	RB	denotes	significantly
T3178	11974-11979	JJR	denotes	lower
T3179	11980-11982	IN	denotes	in
T3180	11983-11985	NN	denotes	BC
T3181	11986-11997	NNS	denotes	individuals
T3182	11998-12006	VBN	denotes	compared
T3183	12007-12009	IN	denotes	to
T3184	12010-12016	JJ	denotes	non-BC
T3185	12017-12028	NNS	denotes	individuals
T3186	12029-12032	CC	denotes	and
T3187	12033-12036	DT	denotes	the
T3188	12037-12047	NN	denotes	difference
T3189	12048-12051	VBD	denotes	was
T3190	12052-12058	RB	denotes	nearly
T3191	12059-12070	JJ	denotes	significant
T3192	12071-12074	IN	denotes	for
T3193	12075-12079	NN	denotes	GPX1
T3194	12080-12081	-LRB-	denotes	(
T3195	12081-12085	NN	denotes	Fig.
T3196	12086-12088	CD	denotes	1b
T3197	12088-12089	-RRB-	denotes	)
T3198	12089-12090	.	denotes	.
T3199	12090-12244	sentence	denotes	Scatter plots of the relationship between CEBPG and XRCC1 in non-BC individuals or BC individuals (Fig. 2a,b) are representative of the other four genes.
T3200	12091-12098	NN	denotes	Scatter
T3201	12099-12104	NNS	denotes	plots
T3202	12201-12204	VBP	denotes	are
T3203	12105-12107	IN	denotes	of
T3204	12108-12111	DT	denotes	the
T3205	12112-12124	NN	denotes	relationship
T3206	12125-12132	IN	denotes	between
T3207	12133-12138	NN	denotes	CEBPG
T3208	12139-12142	CC	denotes	and
T3209	12143-12148	NN	denotes	XRCC1
T3210	12149-12151	IN	denotes	in
T3211	12152-12158	JJ	denotes	non-BC
T3212	12159-12170	NNS	denotes	individuals
T3213	12171-12173	CC	denotes	or
T3214	12174-12176	NN	denotes	BC
T3215	12177-12188	NNS	denotes	individuals
T3216	12189-12190	-LRB-	denotes	(
T3217	12198-12199	NN	denotes	b
T3218	12190-12194	NN	denotes	Fig.
T3219	12195-12197	CD	denotes	2a
T3220	12197-12198	,	denotes	,
T3221	12199-12200	-RRB-	denotes	)
T3222	12205-12219	JJ	denotes	representative
T3223	12220-12222	IN	denotes	of
T3224	12223-12226	DT	denotes	the
T3225	12238-12243	NNS	denotes	genes
T3226	12227-12232	JJ	denotes	other
T3227	12233-12237	CD	denotes	four
T3228	12243-12244	.	denotes	.
T3229	12244-12425	sentence	denotes	Neither CEBPG, nor XRCC1, ERCC5, GSTP1, SOD1 or GPX1 was significantly correlated with age, gender, or smoking history in non-BC individuals, BC individuals, or the combined group.
T3230	12245-12252	CC	denotes	Neither
T3231	12253-12258	NN	denotes	CEBPG
T3232	12316-12326	VBN	denotes	correlated
T3233	12258-12260	,	denotes	,
T3234	12260-12263	CC	denotes	nor
T3235	12264-12269	NN	denotes	XRCC1
T3236	12269-12271	,	denotes	,
T3237	12271-12276	NN	denotes	ERCC5
T3238	12276-12278	,	denotes	,
T3239	12278-12283	NN	denotes	GSTP1
T3240	12283-12285	,	denotes	,
T3241	12285-12289	NN	denotes	SOD1
T3242	12290-12292	CC	denotes	or
T3243	12293-12297	NN	denotes	GPX1
T3244	12298-12301	VBD	denotes	was
T3245	12302-12315	RB	denotes	significantly
T3246	12327-12331	IN	denotes	with
T3247	12332-12335	NN	denotes	age
T3248	12335-12337	,	denotes	,
T3249	12337-12343	NN	denotes	gender
T3250	12343-12345	,	denotes	,
T3251	12345-12347	CC	denotes	or
T3252	12348-12355	NN	denotes	smoking
T3253	12356-12363	NN	denotes	history
T3254	12364-12366	IN	denotes	in
T3255	12367-12373	JJ	denotes	non-BC
T3256	12374-12385	NNS	denotes	individuals
T3257	12385-12387	,	denotes	,
T3258	12387-12389	NN	denotes	BC
T3259	12390-12401	NNS	denotes	individuals
T3260	12401-12403	,	denotes	,
T3261	12403-12405	CC	denotes	or
T3262	12406-12409	DT	denotes	the
T3263	12419-12424	NN	denotes	group
T3264	12410-12418	JJ	denotes	combined
T3265	12424-12425	.	denotes	.
T3266	12425-12632	sentence	denotes	In non-BC individuals, based on the r2 values from Pearson's correlation analysis, CEBPG accounts for much of the variance in expression of XRCC1 (69%), ERCC5 (62%), GSTP1 (55%), SOD1 (44%), and GPX1 (52%).
T3267	12426-12428	IN	denotes	In
T3268	12515-12523	VBZ	denotes	accounts
T3269	12429-12435	JJ	denotes	non-BC
T3270	12436-12447	NNS	denotes	individuals
T3271	12447-12449	,	denotes	,
T3272	12449-12454	VBN	denotes	based
T3273	12455-12457	IN	denotes	on
T3274	12458-12461	DT	denotes	the
T3275	12465-12471	NNS	denotes	values
T3276	12462-12464	NN	denotes	r2
T3277	12472-12476	IN	denotes	from
T3278	12477-12484	NNP	denotes	Pearson
T3279	12499-12507	NN	denotes	analysis
T3280	12484-12486	POS	denotes	's
T3281	12487-12498	NN	denotes	correlation
T3282	12507-12509	,	denotes	,
T3283	12509-12514	NN	denotes	CEBPG
T3284	12524-12527	IN	denotes	for
T3285	12528-12532	JJ	denotes	much
T3286	12533-12535	IN	denotes	of
T3287	12536-12539	DT	denotes	the
T3288	12540-12548	NN	denotes	variance
T3289	12549-12551	IN	denotes	in
T3290	12552-12562	NN	denotes	expression
T3291	12563-12565	IN	denotes	of
T3292	12566-12571	NN	denotes	XRCC1
T3293	12572-12573	-LRB-	denotes	(
T3294	12575-12576	NN	denotes	%
T3295	12573-12575	CD	denotes	69
T3296	12576-12577	-RRB-	denotes	)
T3297	12577-12579	,	denotes	,
T3298	12579-12584	NN	denotes	ERCC5
T3299	12585-12586	-LRB-	denotes	(
T3300	12588-12589	NN	denotes	%
T3301	12586-12588	CD	denotes	62
T3302	12589-12590	-RRB-	denotes	)
T3303	12590-12592	,	denotes	,
T3304	12592-12597	NN	denotes	GSTP1
T3305	12598-12599	-LRB-	denotes	(
T3306	12601-12602	NN	denotes	%
T3307	12599-12601	CD	denotes	55
T3308	12602-12603	-RRB-	denotes	)
T3309	12603-12605	,	denotes	,
T3310	12605-12609	NN	denotes	SOD1
T3311	12610-12611	-LRB-	denotes	(
T3312	12613-12614	NN	denotes	%
T3313	12611-12613	CD	denotes	44
T3314	12614-12615	-RRB-	denotes	)
T3315	12615-12617	,	denotes	,
T3316	12617-12620	CC	denotes	and
T3317	12621-12625	NN	denotes	GPX1
T3318	12626-12627	-LRB-	denotes	(
T3319	12629-12630	NN	denotes	%
T3320	12627-12629	CD	denotes	52
T3321	12630-12631	-RRB-	denotes	)
T3322	12631-12632	.	denotes	.
T3323	12632-12682	sentence	denotes	E2F1 accounts for some of the remaining variance.
T3324	12633-12637	NN	denotes	E2F1
T3325	12638-12646	VBZ	denotes	accounts
T3326	12647-12650	IN	denotes	for
T3327	12651-12655	DT	denotes	some
T3328	12656-12658	IN	denotes	of
T3329	12659-12662	DT	denotes	the
T3330	12673-12681	NN	denotes	variance
T3331	12663-12672	VBG	denotes	remaining
T3332	12681-12682	.	denotes	.
T3333	12682-12863	sentence	denotes	For example, when samples from all 49 non-BC individuals and BC individuals were assessed as a single group, E2F1 was significantly correlated with ERCC5, GSTP1 and SOD1 (Table 4).
T3334	12683-12686	IN	denotes	For
T3335	12815-12825	VBN	denotes	correlated
T3336	12687-12694	NN	denotes	example
T3337	12694-12696	,	denotes	,
T3338	12696-12700	WRB	denotes	when
T3339	12764-12772	VBN	denotes	assessed
T3340	12701-12708	NNS	denotes	samples
T3341	12709-12713	IN	denotes	from
T3342	12714-12717	PDT	denotes	all
T3343	12728-12739	NNS	denotes	individuals
T3344	12718-12720	CD	denotes	49
T3345	12721-12727	JJ	denotes	non-BC
T3346	12740-12743	CC	denotes	and
T3347	12744-12746	NN	denotes	BC
T3348	12747-12758	NNS	denotes	individuals
T3349	12759-12763	VBD	denotes	were
T3350	12773-12775	IN	denotes	as
T3351	12776-12777	DT	denotes	a
T3352	12785-12790	NN	denotes	group
T3353	12778-12784	JJ	denotes	single
T3354	12790-12792	,	denotes	,
T3355	12792-12796	NN	denotes	E2F1
T3356	12797-12800	VBD	denotes	was
T3357	12801-12814	RB	denotes	significantly
T3358	12826-12830	IN	denotes	with
T3359	12831-12836	NN	denotes	ERCC5
T3360	12836-12838	,	denotes	,
T3361	12838-12843	NN	denotes	GSTP1
T3362	12844-12847	CC	denotes	and
T3363	12848-12852	NN	denotes	SOD1
T3364	12853-12854	-LRB-	denotes	(
T3365	12854-12859	NN	denotes	Table
T3366	12860-12861	CD	denotes	4
T3367	12861-12862	-RRB-	denotes	)
T3368	12862-12863	.	denotes	.
T3369	12863-12985	sentence	denotes	Further, in non-BC individuals, E2F1 was correlated with GSTP1 (Fig. 1c) and the correlation was lower in BC individuals.
T3370	12864-12871	RB	denotes	Further
T3371	12905-12915	VBN	denotes	correlated
T3372	12871-12873	,	denotes	,
T3373	12873-12875	IN	denotes	in
T3374	12876-12882	JJ	denotes	non-BC
T3375	12883-12894	NNS	denotes	individuals
T3376	12894-12896	,	denotes	,
T3377	12896-12900	NN	denotes	E2F1
T3378	12901-12904	VBD	denotes	was
T3379	12916-12920	IN	denotes	with
T3380	12921-12926	NN	denotes	GSTP1
T3381	12927-12928	-LRB-	denotes	(
T3382	12928-12932	NN	denotes	Fig.
T3383	12933-12935	CD	denotes	1c
T3384	12935-12936	-RRB-	denotes	)
T3385	12937-12940	CC	denotes	and
T3386	12941-12944	DT	denotes	the
T3387	12945-12956	NN	denotes	correlation
T3388	12957-12960	VBD	denotes	was
T3389	12961-12966	JJR	denotes	lower
T3390	12967-12969	IN	denotes	in
T3391	12970-12972	NN	denotes	BC
T3392	12973-12984	NNS	denotes	individuals
T3393	12984-12985	.	denotes	.
T3394	12985-13091	sentence	denotes	However, the difference in correlation between non-BC individuals and BC individuals was not significant.
T3395	12986-12993	RB	denotes	However
T3396	13071-13074	VBD	denotes	was
T3397	12993-12995	,	denotes	,
T3398	12995-12998	DT	denotes	the
T3399	12999-13009	NN	denotes	difference
T3400	13010-13012	IN	denotes	in
T3401	13013-13024	NN	denotes	correlation
T3402	13025-13032	IN	denotes	between
T3403	13033-13039	JJ	denotes	non-BC
T3404	13040-13051	NNS	denotes	individuals
T3405	13052-13055	CC	denotes	and
T3406	13056-13058	NN	denotes	BC
T3407	13059-13070	NNS	denotes	individuals
T3408	13075-13078	RB	denotes	not
T3409	13079-13090	JJ	denotes	significant
T3410	13090-13091	.	denotes	.
T3411	13091-13204	sentence	denotes	None of the other transcription factors were correlated with XRCC1, ERCC5, GSTP1, SOD1, or GPX1 (Fig. 1a,d,e,f).
T3412	13092-13096	NN	denotes	None
T3413	13137-13147	VBN	denotes	correlated
T3414	13097-13099	IN	denotes	of
T3415	13100-13103	DT	denotes	the
T3416	13124-13131	NNS	denotes	factors
T3417	13104-13109	JJ	denotes	other
T3418	13110-13123	NN	denotes	transcription
T3419	13132-13136	VBD	denotes	were
T3420	13148-13152	IN	denotes	with
T3421	13153-13158	NN	denotes	XRCC1
T3422	13158-13160	,	denotes	,
T3423	13160-13165	NN	denotes	ERCC5
T3424	13165-13167	,	denotes	,
T3425	13167-13172	NN	denotes	GSTP1
T3426	13172-13174	,	denotes	,
T3427	13174-13178	NN	denotes	SOD1
T3428	13178-13180	,	denotes	,
T3429	13180-13182	CC	denotes	or
T3430	13183-13187	NN	denotes	GPX1
T3431	13188-13189	-LRB-	denotes	(
T3432	13201-13202	NN	denotes	f
T3433	13189-13193	NN	denotes	Fig.
T3434	13194-13196	CD	denotes	1a
T3435	13196-13197	,	denotes	,
T3436	13197-13198	NN	denotes	d
T3437	13198-13199	,	denotes	,
T3438	13199-13200	NN	denotes	e
T3439	13200-13201	,	denotes	,
T3440	13202-13203	-RRB-	denotes	)
T3441	13203-13204	.	denotes	.
T3467	13206-13216	NN	denotes	Comparison
T3468	13217-13219	IN	denotes	of
T3469	13220-13224	NN	denotes	gene
T3470	13225-13235	NN	denotes	expression
T3471	13236-13240	IN	denotes	with
T3472	13241-13252	JJ	denotes	demographic
T3473	13253-13268	NNS	denotes	characteristics
T3474	13268-13325	sentence	denotes	E2F1 and GSTZ1 each were positively correlated with age.
T3475	13269-13273	NN	denotes	E2F1
T3476	13305-13315	VBN	denotes	correlated
T3477	13274-13277	CC	denotes	and
T3478	13278-13283	NN	denotes	GSTZ1
T3479	13284-13288	DT	denotes	each
T3480	13289-13293	VBD	denotes	were
T3481	13294-13304	RB	denotes	positively
T3482	13316-13320	IN	denotes	with
T3483	13321-13324	NN	denotes	age
T3484	13324-13325	.	denotes	.
T3485	13325-13394	sentence	denotes	GSTM1-5 was the only gene with a difference in expression by gender.
T3486	13326-13331	NN	denotes	GSTM1
T3487	13334-13337	VBD	denotes	was
T3488	13331-13332	HYPH	denotes	-
T3489	13332-13333	CD	denotes	5
T3490	13338-13341	DT	denotes	the
T3491	13347-13351	NN	denotes	gene
T3492	13342-13346	JJ	denotes	only
T3493	13352-13356	IN	denotes	with
T3494	13357-13358	DT	denotes	a
T3495	13359-13369	NN	denotes	difference
T3496	13370-13372	IN	denotes	in
T3497	13373-13383	NN	denotes	expression
T3498	13384-13386	IN	denotes	by
T3499	13387-13393	NN	denotes	gender
T3500	13393-13394	.	denotes	.
T3501	13394-13471	sentence	denotes	There was a difference in ERCC2 expression between former and never smokers.
T3502	13395-13400	EX	denotes	There
T3503	13401-13404	VBD	denotes	was
T3504	13405-13406	DT	denotes	a
T3505	13407-13417	NN	denotes	difference
T3506	13418-13420	IN	denotes	in
T3507	13421-13426	NN	denotes	ERCC2
T3508	13427-13437	NN	denotes	expression
T3509	13438-13445	IN	denotes	between
T3510	13446-13452	JJ	denotes	former
T3511	13463-13470	NNS	denotes	smokers
T3512	13453-13456	CC	denotes	and
T3513	13457-13462	JJ	denotes	never
T3514	13470-13471	.	denotes	.
T4175	13484-13486	IN	denotes	In
T4176	13502-13508	VBD	denotes	tested
T4177	13487-13491	DT	denotes	this
T4178	13492-13497	NN	denotes	study
T4179	13497-13499	,	denotes	,
T4180	13499-13501	PRP	denotes	we
T4181	13509-13512	CD	denotes	two
T4182	13513-13523	NNS	denotes	hypotheses
T4183	13523-13524	.	denotes	.
T4184	13524-13664	sentence	denotes	First, that there is inter-individual variation in regulation of key antioxidant and DNA repair genes by one or more transcription factors.
T4185	13525-13530	RB	denotes	First
T4186	13543-13545	VBZ	denotes	is
T4187	13530-13532	,	denotes	,
T4188	13532-13536	IN	denotes	that
T4189	13537-13542	EX	denotes	there
T4190	13546-13562	JJ	denotes	inter-individual
T4191	13563-13572	NN	denotes	variation
T4192	13573-13575	IN	denotes	in
T4193	13576-13586	NN	denotes	regulation
T4194	13587-13589	IN	denotes	of
T4195	13590-13593	JJ	denotes	key
T4196	13621-13626	NNS	denotes	genes
T4197	13594-13605	NN	denotes	antioxidant
T4198	13606-13609	CC	denotes	and
T4199	13610-13613	NN	denotes	DNA
T4200	13614-13620	NN	denotes	repair
T4201	13627-13629	IN	denotes	by
T4202	13630-13633	CD	denotes	one
T4203	13656-13663	NNS	denotes	factors
T4204	13634-13636	CC	denotes	or
T4205	13637-13641	JJR	denotes	more
T4206	13642-13655	NN	denotes	transcription
T4207	13663-13664	.	denotes	.
T4208	13664-13778	sentence	denotes	Second, that individuals with sub-optimal regulation are selected for development of BC if they smoke cigarettes.
T4209	13665-13671	RB	denotes	Second
T4210	13722-13730	VBN	denotes	selected
T4211	13671-13673	,	denotes	,
T4212	13673-13677	IN	denotes	that
T4213	13678-13689	NNS	denotes	individuals
T4214	13690-13694	IN	denotes	with
T4215	13695-13706	JJ	denotes	sub-optimal
T4216	13707-13717	NN	denotes	regulation
T4217	13718-13721	VBP	denotes	are
T4218	13731-13734	IN	denotes	for
T4219	13735-13746	NN	denotes	development
T4220	13747-13749	IN	denotes	of
T4221	13750-13752	NN	denotes	BC
T4222	13753-13755	IN	denotes	if
T4223	13761-13766	VBP	denotes	smoke
T4224	13756-13760	PRP	denotes	they
T4225	13767-13777	NNS	denotes	cigarettes
T4226	13777-13778	.	denotes	.
T4227	13778-14242	sentence	denotes	These hypotheses are supported by the findings that a) there was large inter-individual variation in transcript levels of CEBPG and each of the target genes and in non-BC individuals, b) CEBPG transcript abundance values were significantly correlated by bivariate analysis with the transcript abundance values of four key antioxidant and DNA repair genes in non-BC individuals, and c) that there was no correlation between CEBPG and these genes in BC individuals.
T4228	13779-13784	DT	denotes	These
T4229	13785-13795	NNS	denotes	hypotheses
T4230	13800-13809	VBN	denotes	supported
T4231	13796-13799	VBP	denotes	are
T4232	13810-13812	IN	denotes	by
T4233	13813-13816	DT	denotes	the
T4234	13817-13825	NNS	denotes	findings
T4235	13826-13830	IN	denotes	that
T4236	14019-14029	VBN	denotes	correlated
T4237	13831-13832	LS	denotes	a
T4238	13840-13843	VBD	denotes	was
T4239	13832-13833	-RRB-	denotes	)
T4240	13834-13839	EX	denotes	there
T4241	13844-13849	JJ	denotes	large
T4242	13867-13876	NN	denotes	variation
T4243	13850-13866	JJ	denotes	inter-individual
T4244	13877-13879	IN	denotes	in
T4245	13880-13890	NN	denotes	transcript
T4246	13891-13897	NNS	denotes	levels
T4247	13898-13900	IN	denotes	of
T4248	13901-13906	NN	denotes	CEBPG
T4249	13907-13910	CC	denotes	and
T4250	13911-13915	DT	denotes	each
T4251	13916-13918	IN	denotes	of
T4252	13919-13922	DT	denotes	the
T4253	13930-13935	NNS	denotes	genes
T4254	13923-13929	NN	denotes	target
T4255	13936-13939	CC	denotes	and
T4256	13940-13942	IN	denotes	in
T4257	13943-13949	JJ	denotes	non-BC
T4258	13950-13961	NNS	denotes	individuals
T4259	13961-13963	,	denotes	,
T4260	13963-13964	LS	denotes	b
T4261	13964-13965	-RRB-	denotes	)
T4262	13966-13971	NN	denotes	CEBPG
T4263	13993-13999	NNS	denotes	values
T4264	13972-13982	NN	denotes	transcript
T4265	13983-13992	NN	denotes	abundance
T4266	14000-14004	VBD	denotes	were
T4267	14005-14018	RB	denotes	significantly
T4268	14030-14032	IN	denotes	by
T4269	14033-14042	JJ	denotes	bivariate
T4270	14043-14051	NN	denotes	analysis
T4271	14052-14056	IN	denotes	with
T4272	14057-14060	DT	denotes	the
T4273	14082-14088	NNS	denotes	values
T4274	14061-14071	NN	denotes	transcript
T4275	14072-14081	NN	denotes	abundance
T4276	14089-14091	IN	denotes	of
T4277	14092-14096	CD	denotes	four
T4278	14128-14133	NNS	denotes	genes
T4279	14097-14100	JJ	denotes	key
T4280	14101-14112	NN	denotes	antioxidant
T4281	14113-14116	CC	denotes	and
T4282	14117-14120	NN	denotes	DNA
T4283	14121-14127	NN	denotes	repair
T4284	14134-14136	IN	denotes	in
T4285	14137-14143	JJ	denotes	non-BC
T4286	14144-14155	NNS	denotes	individuals
T4287	14155-14157	,	denotes	,
T4288	14157-14160	CC	denotes	and
T4289	14161-14162	LS	denotes	c
T4290	14175-14178	VBD	denotes	was
T4291	14162-14163	-RRB-	denotes	)
T4292	14164-14168	IN	denotes	that
T4293	14169-14174	EX	denotes	there
T4294	14179-14181	DT	denotes	no
T4295	14182-14193	NN	denotes	correlation
T4296	14194-14201	IN	denotes	between
T4297	14202-14207	NN	denotes	CEBPG
T4298	14208-14211	CC	denotes	and
T4299	14212-14217	DT	denotes	these
T4300	14218-14223	NNS	denotes	genes
T4301	14224-14226	IN	denotes	in
T4302	14227-14229	NN	denotes	BC
T4303	14230-14241	NNS	denotes	individuals
T4304	14241-14242	.	denotes	.
T4305	14242-14395	sentence	denotes	These results support the hypothesis that each of the antioxidant or DNA repair genes correlated with CEBPG in non-BC individuals is regulated by CEBPG.
T4306	14243-14248	DT	denotes	These
T4307	14249-14256	NNS	denotes	results
T4308	14257-14264	VBP	denotes	support
T4309	14265-14268	DT	denotes	the
T4310	14269-14279	NN	denotes	hypothesis
T4311	14280-14284	IN	denotes	that
T4312	14376-14385	VBN	denotes	regulated
T4313	14285-14289	DT	denotes	each
T4314	14290-14292	IN	denotes	of
T4315	14293-14296	DT	denotes	the
T4316	14323-14328	NNS	denotes	genes
T4317	14297-14308	NN	denotes	antioxidant
T4318	14309-14311	CC	denotes	or
T4319	14312-14315	NN	denotes	DNA
T4320	14316-14322	NN	denotes	repair
T4321	14329-14339	VBN	denotes	correlated
T4322	14340-14344	IN	denotes	with
T4323	14345-14350	NN	denotes	CEBPG
T4324	14351-14353	IN	denotes	in
T4325	14354-14360	JJ	denotes	non-BC
T4326	14361-14372	NNS	denotes	individuals
T4327	14373-14375	VBZ	denotes	is
T4328	14386-14388	IN	denotes	by
T4329	14389-14394	NN	denotes	CEBPG
T4330	14394-14395	.	denotes	.
T4331	14395-14458	sentence	denotes	This is supported by the specificity of the CEBPG correlation.
T4332	14396-14400	DT	denotes	This
T4333	14404-14413	VBN	denotes	supported
T4334	14401-14403	VBZ	denotes	is
T4335	14414-14416	IN	denotes	by
T4336	14417-14420	DT	denotes	the
T4337	14421-14432	NN	denotes	specificity
T4338	14433-14435	IN	denotes	of
T4339	14436-14439	DT	denotes	the
T4340	14446-14457	NN	denotes	correlation
T4341	14440-14445	NN	denotes	CEBPG
T4342	14457-14458	.	denotes	.
T4343	14458-14582	sentence	denotes	That is, there was lack of correlation between any of the other five transcription factors assessed and these target genes.
T4344	14459-14463	RB	denotes	That
T4345	14464-14466	RB	denotes	is
T4346	14474-14477	VBD	denotes	was
T4347	14466-14468	,	denotes	,
T4348	14468-14473	EX	denotes	there
T4349	14478-14482	NN	denotes	lack
T4350	14483-14485	IN	denotes	of
T4351	14486-14497	NN	denotes	correlation
T4352	14498-14505	IN	denotes	between
T4353	14506-14509	DT	denotes	any
T4354	14510-14512	IN	denotes	of
T4355	14513-14516	DT	denotes	the
T4356	14542-14549	NNS	denotes	factors
T4357	14517-14522	JJ	denotes	other
T4358	14523-14527	CD	denotes	five
T4359	14528-14541	NN	denotes	transcription
T4360	14550-14558	VBN	denotes	assessed
T4361	14559-14562	CC	denotes	and
T4362	14563-14568	DT	denotes	these
T4363	14576-14581	NNS	denotes	genes
T4364	14569-14575	NN	denotes	target
T4365	14581-14582	.	denotes	.
T4366	14582-14795	sentence	denotes	Of particular note is the lack of correlation of the target genes with CEBPB, which binds to the same recognition site as CEBPG, and shares its recognition site within each of the antioxidant or DNA repair genes.
T4367	14583-14585	IN	denotes	Of
T4368	14602-14604	VBZ	denotes	is
T4369	14586-14596	JJ	denotes	particular
T4370	14597-14601	NN	denotes	note
T4371	14605-14608	DT	denotes	the
T4372	14609-14613	NN	denotes	lack
T4373	14614-14616	IN	denotes	of
T4374	14617-14628	NN	denotes	correlation
T4375	14629-14631	IN	denotes	of
T4376	14632-14635	DT	denotes	the
T4377	14643-14648	NNS	denotes	genes
T4378	14636-14642	NN	denotes	target
T4379	14649-14653	IN	denotes	with
T4380	14654-14659	NN	denotes	CEBPB
T4381	14659-14661	,	denotes	,
T4382	14661-14666	WDT	denotes	which
T4383	14667-14672	VBZ	denotes	binds
T4384	14673-14675	IN	denotes	to
T4385	14676-14679	DT	denotes	the
T4386	14697-14701	NN	denotes	site
T4387	14680-14684	JJ	denotes	same
T4388	14685-14696	NN	denotes	recognition
T4389	14702-14704	IN	denotes	as
T4390	14705-14710	NN	denotes	CEBPG
T4391	14710-14712	,	denotes	,
T4392	14712-14715	CC	denotes	and
T4393	14716-14722	VBZ	denotes	shares
T4394	14723-14726	PRP$	denotes	its
T4395	14739-14743	NN	denotes	site
T4396	14727-14738	NN	denotes	recognition
T4397	14744-14750	IN	denotes	within
T4398	14751-14755	DT	denotes	each
T4399	14756-14758	IN	denotes	of
T4400	14759-14762	DT	denotes	the
T4401	14789-14794	NNS	denotes	genes
T4402	14763-14774	NN	denotes	antioxidant
T4403	14775-14777	CC	denotes	or
T4404	14778-14781	NN	denotes	DNA
T4405	14782-14788	NN	denotes	repair
T4406	14794-14795	.	denotes	.
T4407	14795-14938	sentence	denotes	However, there are alternative explanations for the observed correlation of CEBPG with antioxidant and DNA repair genes in non-BC individuals.
T4408	14796-14803	RB	denotes	However
T4409	14811-14814	VBP	denotes	are
T4410	14803-14805	,	denotes	,
T4411	14805-14810	EX	denotes	there
T4412	14815-14826	JJ	denotes	alternative
T4413	14827-14839	NNS	denotes	explanations
T4414	14840-14843	IN	denotes	for
T4415	14844-14847	DT	denotes	the
T4416	14857-14868	NN	denotes	correlation
T4417	14848-14856	VBN	denotes	observed
T4418	14869-14871	IN	denotes	of
T4419	14872-14877	NN	denotes	CEBPG
T4420	14878-14882	IN	denotes	with
T4421	14883-14894	NN	denotes	antioxidant
T4422	14910-14915	NNS	denotes	genes
T4423	14895-14898	CC	denotes	and
T4424	14899-14902	NN	denotes	DNA
T4425	14903-14909	NN	denotes	repair
T4426	14916-14918	IN	denotes	in
T4427	14919-14925	JJ	denotes	non-BC
T4428	14926-14937	NNS	denotes	individuals
T4429	14937-14938	.	denotes	.
T4430	14938-15195	sentence	denotes	One possibility is that CEBPG and each of the correlated antioxidant or DNA repair genes is regulated by a transcription factor that is as yet undiscovered, and/or has a recognition site that is not yet known and was not in the Genomatix software database.
T4431	14939-14942	CD	denotes	One
T4432	14943-14954	NN	denotes	possibility
T4433	14955-14957	VBZ	denotes	is
T4434	14958-14962	IN	denotes	that
T4435	15031-15040	VBN	denotes	regulated
T4436	14963-14968	NN	denotes	CEBPG
T4437	14969-14972	CC	denotes	and
T4438	14973-14977	DT	denotes	each
T4439	14978-14980	IN	denotes	of
T4440	14981-14984	DT	denotes	the
T4441	15022-15027	NNS	denotes	genes
T4442	14985-14995	VBN	denotes	correlated
T4443	14996-15007	NN	denotes	antioxidant
T4444	15008-15010	CC	denotes	or
T4445	15011-15014	NN	denotes	DNA
T4446	15015-15021	NN	denotes	repair
T4447	15028-15030	VBZ	denotes	is
T4448	15041-15043	IN	denotes	by
T4449	15044-15045	DT	denotes	a
T4450	15060-15066	NN	denotes	factor
T4451	15046-15059	NN	denotes	transcription
T4452	15067-15071	WDT	denotes	that
T4453	15072-15074	VBZ	denotes	is
T4454	15075-15077	RB	denotes	as
T4455	15078-15081	RB	denotes	yet
T4456	15082-15094	JJ	denotes	undiscovered
T4457	15094-15096	,	denotes	,
T4458	15096-15099	CC	denotes	and
T4459	15099-15100	HYPH	denotes	/
T4460	15100-15102	CC	denotes	or
T4461	15103-15106	VBZ	denotes	has
T4462	15107-15108	DT	denotes	a
T4463	15121-15125	NN	denotes	site
T4464	15109-15120	NN	denotes	recognition
T4465	15126-15130	WDT	denotes	that
T4466	15142-15147	VBN	denotes	known
T4467	15131-15133	VBZ	denotes	is
T4468	15134-15137	RB	denotes	not
T4469	15138-15141	RB	denotes	yet
T4470	15148-15151	CC	denotes	and
T4471	15152-15155	VBD	denotes	was
T4472	15156-15159	RB	denotes	not
T4473	15160-15162	IN	denotes	in
T4474	15163-15166	DT	denotes	the
T4475	15186-15194	NN	denotes	database
T4476	15167-15176	NNP	denotes	Genomatix
T4477	15177-15185	NN	denotes	software
T4478	15194-15195	.	denotes	.
T4479	15195-15350	sentence	denotes	There also is more than one possible explanation for the observed lack of correlation between CEBPG and antioxidant or DNA repair genes in BC individuals.
T4480	15196-15201	EX	denotes	There
T4481	15207-15209	VBZ	denotes	is
T4482	15202-15206	RB	denotes	also
T4483	15210-15214	JJR	denotes	more
T4484	15220-15223	CD	denotes	one
T4485	15215-15219	IN	denotes	than
T4486	15233-15244	NN	denotes	explanation
T4487	15224-15232	JJ	denotes	possible
T4488	15245-15248	IN	denotes	for
T4489	15249-15252	DT	denotes	the
T4490	15262-15266	NN	denotes	lack
T4491	15253-15261	VBN	denotes	observed
T4492	15267-15269	IN	denotes	of
T4493	15270-15281	NN	denotes	correlation
T4494	15282-15289	IN	denotes	between
T4495	15290-15295	NN	denotes	CEBPG
T4496	15296-15299	CC	denotes	and
T4497	15300-15311	NN	denotes	antioxidant
T4498	15326-15331	NNS	denotes	genes
T4499	15312-15314	CC	denotes	or
T4500	15315-15318	NN	denotes	DNA
T4501	15319-15325	NN	denotes	repair
T4502	15332-15334	IN	denotes	in
T4503	15335-15337	NN	denotes	BC
T4504	15338-15349	NNS	denotes	individuals
T4505	15349-15350	.	denotes	.
T4506	15350-15594	sentence	denotes	For example, the non-BC individual and BC individual groups are not perfectly matched with respect to age, gender or smoking history (Table 1) and each of these factors could contribute to the observed difference in correlation between groups.
T4507	15351-15354	IN	denotes	For
T4508	15429-15436	VBN	denotes	matched
T4509	15355-15362	NN	denotes	example
T4510	15362-15364	,	denotes	,
T4511	15364-15367	DT	denotes	the
T4512	15404-15410	NNS	denotes	groups
T4513	15368-15374	JJ	denotes	non-BC
T4514	15375-15385	NN	denotes	individual
T4515	15386-15389	CC	denotes	and
T4516	15390-15392	NN	denotes	BC
T4517	15393-15403	JJ	denotes	individual
T4518	15411-15414	VBP	denotes	are
T4519	15415-15418	RB	denotes	not
T4520	15419-15428	RB	denotes	perfectly
T4521	15437-15441	IN	denotes	with
T4522	15442-15449	NN	denotes	respect
T4523	15450-15452	IN	denotes	to
T4524	15453-15456	NN	denotes	age
T4525	15456-15458	,	denotes	,
T4526	15458-15464	NN	denotes	gender
T4527	15465-15467	CC	denotes	or
T4528	15468-15475	NN	denotes	smoking
T4529	15476-15483	NN	denotes	history
T4530	15484-15485	-LRB-	denotes	(
T4531	15485-15490	NN	denotes	Table
T4532	15491-15492	CD	denotes	1
T4533	15492-15493	-RRB-	denotes	)
T4534	15494-15497	CC	denotes	and
T4535	15498-15502	DT	denotes	each
T4536	15526-15536	VB	denotes	contribute
T4537	15503-15505	IN	denotes	of
T4538	15506-15511	DT	denotes	these
T4539	15512-15519	NNS	denotes	factors
T4540	15520-15525	MD	denotes	could
T4541	15537-15539	IN	denotes	to
T4542	15540-15543	DT	denotes	the
T4543	15553-15563	NN	denotes	difference
T4544	15544-15552	VBN	denotes	observed
T4545	15564-15566	IN	denotes	in
T4546	15567-15578	NN	denotes	correlation
T4547	15579-15586	IN	denotes	between
T4548	15587-15593	NNS	denotes	groups
T4549	15593-15594	.	denotes	.
T4550	15594-15775	sentence	denotes	However, the lack of association of transcript abundance level for CEBPG, XRCC1, ERCC5, GSTP1, SOD1, or GPX1 with age, gender or smoking history argues against such an explanation.
T4551	15595-15602	RB	denotes	However
T4552	15740-15746	VBZ	denotes	argues
T4553	15602-15604	,	denotes	,
T4554	15604-15607	DT	denotes	the
T4555	15608-15612	NN	denotes	lack
T4556	15613-15615	IN	denotes	of
T4557	15616-15627	NN	denotes	association
T4558	15628-15630	IN	denotes	of
T4559	15631-15641	NN	denotes	transcript
T4560	15642-15651	NN	denotes	abundance
T4561	15652-15657	NN	denotes	level
T4562	15658-15661	IN	denotes	for
T4563	15662-15667	NN	denotes	CEBPG
T4564	15667-15669	,	denotes	,
T4565	15669-15674	NN	denotes	XRCC1
T4566	15674-15676	,	denotes	,
T4567	15676-15681	NN	denotes	ERCC5
T4568	15681-15683	,	denotes	,
T4569	15683-15688	NN	denotes	GSTP1
T4570	15688-15690	,	denotes	,
T4571	15690-15694	NN	denotes	SOD1
T4572	15694-15696	,	denotes	,
T4573	15696-15698	CC	denotes	or
T4574	15699-15703	NN	denotes	GPX1
T4575	15704-15708	IN	denotes	with
T4576	15709-15712	NN	denotes	age
T4577	15712-15714	,	denotes	,
T4578	15714-15720	NN	denotes	gender
T4579	15721-15723	CC	denotes	or
T4580	15724-15731	NN	denotes	smoking
T4581	15732-15739	NN	denotes	history
T4582	15747-15754	IN	denotes	against
T4583	15755-15759	PDT	denotes	such
T4584	15763-15774	NN	denotes	explanation
T4585	15760-15762	DT	denotes	an
T4586	15774-15775	.	denotes	.
T4587	15775-15872	sentence	denotes	One way to examine this possibility is through additional, larger, more closely matched studies.
T4588	15776-15779	CD	denotes	One
T4589	15780-15783	NN	denotes	way
T4590	15812-15814	VBZ	denotes	is
T4591	15784-15786	TO	denotes	to
T4592	15787-15794	VB	denotes	examine
T4593	15795-15799	DT	denotes	this
T4594	15800-15811	NN	denotes	possibility
T4595	15815-15822	IN	denotes	through
T4596	15823-15833	JJ	denotes	additional
T4597	15864-15871	NNS	denotes	studies
T4598	15833-15835	,	denotes	,
T4599	15835-15841	JJR	denotes	larger
T4600	15841-15843	,	denotes	,
T4601	15843-15847	RBR	denotes	more
T4602	15848-15855	RB	denotes	closely
T4603	15856-15863	VBN	denotes	matched
T4604	15871-15872	.	denotes	.
T4605	15872-16083	sentence	denotes	Another possible explanation is that any differences in NBEC from BC individuals compared to non-BC individuals resulted from development of BC, instead of being a hereditary cause of increased risk for cancer.
T4606	15873-15880	DT	denotes	Another
T4607	15890-15901	NN	denotes	explanation
T4608	15881-15889	JJ	denotes	possible
T4609	15902-15904	VBZ	denotes	is
T4610	15905-15909	IN	denotes	that
T4611	15985-15993	VBD	denotes	resulted
T4612	15910-15913	DT	denotes	any
T4613	15914-15925	NNS	denotes	differences
T4614	15926-15928	IN	denotes	in
T4615	15929-15933	NN	denotes	NBEC
T4616	15934-15938	IN	denotes	from
T4617	15939-15941	NN	denotes	BC
T4618	15942-15953	NNS	denotes	individuals
T4619	15954-15962	VBN	denotes	compared
T4620	15963-15965	IN	denotes	to
T4621	15966-15972	JJ	denotes	non-BC
T4622	15973-15984	NNS	denotes	individuals
T4623	15994-15998	IN	denotes	from
T4624	15999-16010	NN	denotes	development
T4625	16011-16013	IN	denotes	of
T4626	16014-16016	NN	denotes	BC
T4627	16016-16018	,	denotes	,
T4628	16018-16025	RB	denotes	instead
T4629	16026-16028	IN	denotes	of
T4630	16029-16034	VBG	denotes	being
T4631	16035-16036	DT	denotes	a
T4632	16048-16053	NN	denotes	cause
T4633	16037-16047	JJ	denotes	hereditary
T4634	16054-16056	IN	denotes	of
T4635	16057-16066	VBN	denotes	increased
T4636	16067-16071	NN	denotes	risk
T4637	16072-16075	IN	denotes	for
T4638	16076-16082	NN	denotes	cancer
T4639	16082-16083	.	denotes	.
T4640	16083-16154	sentence	denotes	The best way to determine this will be to conduct a prospective study.
T4641	16084-16087	DT	denotes	The
T4642	16093-16096	NN	denotes	way
T4643	16088-16092	JJS	denotes	best
T4644	16120-16122	VB	denotes	be
T4645	16097-16099	TO	denotes	to
T4646	16100-16109	VB	denotes	determine
T4647	16110-16114	DT	denotes	this
T4648	16115-16119	MD	denotes	will
T4649	16123-16125	TO	denotes	to
T4650	16126-16133	VB	denotes	conduct
T4651	16134-16135	DT	denotes	a
T4652	16148-16153	NN	denotes	study
T4653	16136-16147	JJ	denotes	prospective
T4654	16153-16154	.	denotes	.
T4655	16154-16262	sentence	denotes	In such a study, individuals matched for smoking history will be monitored for development of BC over time.
T4656	16155-16157	IN	denotes	In
T4657	16220-16229	VBN	denotes	monitored
T4658	16158-16162	PDT	denotes	such
T4659	16165-16170	NN	denotes	study
T4660	16163-16164	DT	denotes	a
T4661	16170-16172	,	denotes	,
T4662	16172-16183	NNS	denotes	individuals
T4663	16184-16191	VBN	denotes	matched
T4664	16192-16195	IN	denotes	for
T4665	16196-16203	NN	denotes	smoking
T4666	16204-16211	NN	denotes	history
T4667	16212-16216	MD	denotes	will
T4668	16217-16219	VB	denotes	be
T4669	16230-16233	IN	denotes	for
T4670	16234-16245	NN	denotes	development
T4671	16246-16248	IN	denotes	of
T4672	16249-16251	NN	denotes	BC
T4673	16252-16256	IN	denotes	over
T4674	16257-16261	NN	denotes	time
T4675	16261-16262	.	denotes	.
T4676	16262-16425	sentence	denotes	The correlation of transcript abundance values for CEBPG relative to transcript abundance values for each of the antioxidant or DNA repair genes will be assessed.
T4677	16263-16266	DT	denotes	The
T4678	16267-16278	NN	denotes	correlation
T4679	16416-16424	VBN	denotes	assessed
T4680	16279-16281	IN	denotes	of
T4681	16282-16292	NN	denotes	transcript
T4682	16293-16302	NN	denotes	abundance
T4683	16303-16309	NNS	denotes	values
T4684	16310-16313	IN	denotes	for
T4685	16314-16319	NN	denotes	CEBPG
T4686	16320-16328	JJ	denotes	relative
T4687	16329-16331	IN	denotes	to
T4688	16332-16342	NN	denotes	transcript
T4689	16343-16352	NN	denotes	abundance
T4690	16353-16359	NNS	denotes	values
T4691	16360-16363	IN	denotes	for
T4692	16364-16368	DT	denotes	each
T4693	16369-16371	IN	denotes	of
T4694	16372-16375	DT	denotes	the
T4695	16402-16407	NNS	denotes	genes
T4696	16376-16387	NN	denotes	antioxidant
T4697	16388-16390	CC	denotes	or
T4698	16391-16394	NN	denotes	DNA
T4699	16395-16401	NN	denotes	repair
T4700	16408-16412	MD	denotes	will
T4701	16413-16415	VB	denotes	be
T4702	16424-16425	.	denotes	.
T4703	16425-16510	sentence	denotes	It is expected that the greatest incidence of BC will be among the heaviest smokers.
T4704	16426-16428	PRP	denotes	It
T4705	16432-16440	VBN	denotes	expected
T4706	16429-16431	VBZ	denotes	is
T4707	16441-16445	IN	denotes	that
T4708	16480-16482	VB	denotes	be
T4709	16446-16449	DT	denotes	the
T4710	16459-16468	NN	denotes	incidence
T4711	16450-16458	JJS	denotes	greatest
T4712	16469-16471	IN	denotes	of
T4713	16472-16474	NN	denotes	BC
T4714	16475-16479	MD	denotes	will
T4715	16483-16488	IN	denotes	among
T4716	16489-16492	DT	denotes	the
T4717	16502-16509	NNS	denotes	smokers
T4718	16493-16501	JJS	denotes	heaviest
T4719	16509-16510	.	denotes	.
T4720	16510-16721	sentence	denotes	Among the matched heaviest smokers, it is expected that CEBPG will be significantly correlated with each of the antioxidant or DNA repair genes among the non-BC individuals but not correlated in BC individuals.
T4721	16511-16516	IN	denotes	Among
T4722	16553-16561	VBN	denotes	expected
T4723	16517-16520	DT	denotes	the
T4724	16538-16545	NNS	denotes	smokers
T4725	16521-16528	VBN	denotes	matched
T4726	16529-16537	JJS	denotes	heaviest
T4727	16545-16547	,	denotes	,
T4728	16547-16549	PRP	denotes	it
T4729	16550-16552	VBZ	denotes	is
T4730	16562-16566	IN	denotes	that
T4731	16595-16605	VBN	denotes	correlated
T4732	16567-16572	NN	denotes	CEBPG
T4733	16573-16577	MD	denotes	will
T4734	16578-16580	VB	denotes	be
T4735	16581-16594	RB	denotes	significantly
T4736	16606-16610	IN	denotes	with
T4737	16611-16615	DT	denotes	each
T4738	16616-16618	IN	denotes	of
T4739	16619-16622	DT	denotes	the
T4740	16649-16654	NNS	denotes	genes
T4741	16623-16634	NN	denotes	antioxidant
T4742	16635-16637	CC	denotes	or
T4743	16638-16641	NN	denotes	DNA
T4744	16642-16648	NN	denotes	repair
T4745	16655-16660	IN	denotes	among
T4746	16661-16664	DT	denotes	the
T4747	16672-16683	NNS	denotes	individuals
T4748	16665-16671	JJ	denotes	non-BC
T4749	16684-16687	CC	denotes	but
T4750	16688-16691	RB	denotes	not
T4751	16692-16702	VBN	denotes	correlated
T4752	16703-16705	IN	denotes	in
T4753	16706-16708	NN	denotes	BC
T4754	16709-16720	NNS	denotes	individuals
T4755	16720-16721	.	denotes	.
T4756	16721-16795	sentence	denotes	Thus, there are multiple possible explanations for the observed findings.
T4757	16722-16726	RB	denotes	Thus
T4758	16734-16737	VBP	denotes	are
T4759	16726-16728	,	denotes	,
T4760	16728-16733	EX	denotes	there
T4761	16738-16746	JJ	denotes	multiple
T4762	16756-16768	NNS	denotes	explanations
T4763	16747-16755	JJ	denotes	possible
T4764	16769-16772	IN	denotes	for
T4765	16773-16776	DT	denotes	the
T4766	16786-16794	NNS	denotes	findings
T4767	16777-16785	VBN	denotes	observed
T4768	16794-16795	.	denotes	.
T4769	16795-17079	sentence	denotes	However, based on the preponderance of data thus far available, we conclude that CEBPG is responsible for optimal transcriptional regulation of key antioxidant or DNA repair genes in NBEC and that there is inter-individual variation in the regulation of each of these genes by CEBPG.
T4770	16796-16803	RB	denotes	However
T4771	16863-16871	VBP	denotes	conclude
T4772	16803-16805	,	denotes	,
T4773	16805-16810	VBN	denotes	based
T4774	16811-16813	IN	denotes	on
T4775	16814-16817	DT	denotes	the
T4776	16818-16831	NN	denotes	preponderance
T4777	16832-16834	IN	denotes	of
T4778	16835-16839	NNS	denotes	data
T4779	16840-16844	RB	denotes	thus
T4780	16845-16848	RB	denotes	far
T4781	16849-16858	JJ	denotes	available
T4782	16858-16860	,	denotes	,
T4783	16860-16862	PRP	denotes	we
T4784	16872-16876	IN	denotes	that
T4785	16883-16885	VBZ	denotes	is
T4786	16877-16882	NN	denotes	CEBPG
T4787	16886-16897	JJ	denotes	responsible
T4788	16898-16901	IN	denotes	for
T4789	16902-16909	JJ	denotes	optimal
T4790	16926-16936	NN	denotes	regulation
T4791	16910-16925	JJ	denotes	transcriptional
T4792	16937-16939	IN	denotes	of
T4793	16940-16943	JJ	denotes	key
T4794	16970-16975	NNS	denotes	genes
T4795	16944-16955	JJ	denotes	antioxidant
T4796	16956-16958	CC	denotes	or
T4797	16959-16962	NN	denotes	DNA
T4798	16963-16969	NN	denotes	repair
T4799	16976-16978	IN	denotes	in
T4800	16979-16983	NN	denotes	NBEC
T4801	16984-16987	CC	denotes	and
T4802	16988-16992	IN	denotes	that
T4803	16999-17001	VBZ	denotes	is
T4804	16993-16998	EX	denotes	there
T4805	17002-17018	JJ	denotes	inter-individual
T4806	17019-17028	NN	denotes	variation
T4807	17029-17031	IN	denotes	in
T4808	17032-17035	DT	denotes	the
T4809	17036-17046	NN	denotes	regulation
T4810	17047-17049	IN	denotes	of
T4811	17050-17054	DT	denotes	each
T4812	17055-17057	IN	denotes	of
T4813	17058-17063	DT	denotes	these
T4814	17064-17069	NNS	denotes	genes
T4815	17070-17072	IN	denotes	by
T4816	17073-17078	NN	denotes	CEBPG
T4817	17078-17079	.	denotes	.
T4818	17079-17298	sentence	denotes	If this conclusion is correct, the individuals at greatest risk for BC will be those with the most extreme smoking history combined with sub-optimal regulation of the largest number of antioxidant and DNA repair genes.
T4819	17080-17082	IN	denotes	If
T4820	17099-17101	VBZ	denotes	is
T4821	17083-17087	DT	denotes	this
T4822	17088-17098	NN	denotes	conclusion
T4823	17156-17158	VB	denotes	be
T4824	17102-17109	JJ	denotes	correct
T4825	17109-17111	,	denotes	,
T4826	17111-17114	DT	denotes	the
T4827	17115-17126	NNS	denotes	individuals
T4828	17127-17129	IN	denotes	at
T4829	17130-17138	JJS	denotes	greatest
T4830	17139-17143	NN	denotes	risk
T4831	17144-17147	IN	denotes	for
T4832	17148-17150	NN	denotes	BC
T4833	17151-17155	MD	denotes	will
T4834	17159-17164	DT	denotes	those
T4835	17165-17169	IN	denotes	with
T4836	17170-17173	DT	denotes	the
T4837	17195-17202	NN	denotes	history
T4838	17174-17178	RBS	denotes	most
T4839	17179-17186	JJ	denotes	extreme
T4840	17187-17194	NN	denotes	smoking
T4841	17203-17211	VBN	denotes	combined
T4842	17212-17216	IN	denotes	with
T4843	17217-17228	JJ	denotes	sub-optimal
T4844	17229-17239	NN	denotes	regulation
T4845	17240-17242	IN	denotes	of
T4846	17243-17246	DT	denotes	the
T4847	17255-17261	NN	denotes	number
T4848	17247-17254	JJS	denotes	largest
T4849	17262-17264	IN	denotes	of
T4850	17265-17276	NN	denotes	antioxidant
T4851	17292-17297	NNS	denotes	genes
T4852	17277-17280	CC	denotes	and
T4853	17281-17284	NN	denotes	DNA
T4854	17285-17291	NN	denotes	repair
T4855	17297-17298	.	denotes	.
T4856	17298-17484	sentence	denotes	This, in turn, leads to increased representation among BC individuals of individuals with lack of correlation between CEBPG and each of the affected antioxidant and/or DNA repair genes.
T4857	17299-17303	DT	denotes	This
T4858	17314-17319	VBZ	denotes	leads
T4859	17303-17305	,	denotes	,
T4860	17305-17307	IN	denotes	in
T4861	17308-17312	NN	denotes	turn
T4862	17312-17314	,	denotes	,
T4863	17320-17322	IN	denotes	to
T4864	17323-17332	VBN	denotes	increased
T4865	17333-17347	NN	denotes	representation
T4866	17348-17353	IN	denotes	among
T4867	17354-17356	NN	denotes	BC
T4868	17357-17368	NNS	denotes	individuals
T4869	17369-17371	IN	denotes	of
T4870	17372-17383	NNS	denotes	individuals
T4871	17384-17388	IN	denotes	with
T4872	17389-17393	NN	denotes	lack
T4873	17394-17396	IN	denotes	of
T4874	17397-17408	NN	denotes	correlation
T4875	17409-17416	IN	denotes	between
T4876	17417-17422	NN	denotes	CEBPG
T4877	17423-17426	CC	denotes	and
T4878	17427-17431	DT	denotes	each
T4879	17432-17434	IN	denotes	of
T4880	17435-17438	DT	denotes	the
T4881	17478-17483	NNS	denotes	genes
T4882	17439-17447	VBN	denotes	affected
T4883	17448-17459	NN	denotes	antioxidant
T4884	17460-17463	CC	denotes	and
T4885	17463-17464	HYPH	denotes	/
T4886	17464-17466	CC	denotes	or
T4887	17467-17470	NN	denotes	DNA
T4888	17471-17477	NN	denotes	repair
T4889	17483-17484	.	denotes	.
T4890	17484-17677	sentence	denotes	CEBPG is a truncated CEBP transcription factor [19] and possesses the sequences necessary for DNA binding and heterodimer formation, but lacks the sequences necessary for transactivation [20].
T4891	17485-17490	NN	denotes	CEBPG
T4892	17491-17493	VBZ	denotes	is
T4893	17494-17495	DT	denotes	a
T4894	17525-17531	NN	denotes	factor
T4895	17496-17505	VBN	denotes	truncated
T4896	17506-17510	NN	denotes	CEBP
T4897	17511-17524	NN	denotes	transcription
T4898	17532-17533	-LRB-	denotes	[
T4899	17533-17535	CD	denotes	19
T4900	17535-17536	-RRB-	denotes	]
T4901	17537-17540	CC	denotes	and
T4902	17541-17550	VBZ	denotes	possesses
T4903	17551-17554	DT	denotes	the
T4904	17555-17564	NNS	denotes	sequences
T4905	17565-17574	JJ	denotes	necessary
T4906	17575-17578	IN	denotes	for
T4907	17579-17582	NN	denotes	DNA
T4908	17583-17590	NN	denotes	binding
T4909	17591-17594	CC	denotes	and
T4910	17595-17606	NN	denotes	heterodimer
T4911	17607-17616	NN	denotes	formation
T4912	17616-17618	,	denotes	,
T4913	17618-17621	CC	denotes	but
T4914	17622-17627	VBZ	denotes	lacks
T4915	17628-17631	DT	denotes	the
T4916	17632-17641	NNS	denotes	sequences
T4917	17642-17651	JJ	denotes	necessary
T4918	17652-17655	IN	denotes	for
T4919	17656-17671	NN	denotes	transactivation
T4920	17672-17673	-LRB-	denotes	[
T4921	17673-17675	CD	denotes	20
T4922	17675-17676	-RRB-	denotes	]
T4923	17676-17677	.	denotes	.
T4924	17677-17838	sentence	denotes	CEBPG forms heterodimers with other CEBP family members and in other tissues this leads to increased [21] or decreased [20] transcription of the regulated gene.
T4925	17678-17683	NN	denotes	CEBPG
T4926	17684-17689	VBZ	denotes	forms
T4927	17690-17702	NNS	denotes	heterodimers
T4928	17703-17707	IN	denotes	with
T4929	17708-17713	JJ	denotes	other
T4930	17726-17733	NNS	denotes	members
T4931	17714-17718	NN	denotes	CEBP
T4932	17719-17725	NN	denotes	family
T4933	17734-17737	CC	denotes	and
T4934	17738-17740	IN	denotes	in
T4935	17760-17765	VBZ	denotes	leads
T4936	17741-17746	JJ	denotes	other
T4937	17747-17754	NNS	denotes	tissues
T4938	17755-17759	DT	denotes	this
T4939	17766-17768	IN	denotes	to
T4940	17769-17778	VBN	denotes	increased
T4941	17802-17815	NN	denotes	transcription
T4942	17779-17780	-LRB-	denotes	[
T4943	17780-17782	CD	denotes	21
T4944	17782-17783	-RRB-	denotes	]
T4945	17784-17786	CC	denotes	or
T4946	17787-17796	VBN	denotes	decreased
T4947	17797-17798	-LRB-	denotes	[
T4948	17798-17800	CD	denotes	20
T4949	17800-17801	-RRB-	denotes	]
T4950	17816-17818	IN	denotes	of
T4951	17819-17822	DT	denotes	the
T4952	17833-17837	NN	denotes	gene
T4953	17823-17832	VBN	denotes	regulated
T4954	17837-17838	.	denotes	.
T4955	17838-18039	sentence	denotes	CEBPG is known to have stimulatory effect on the IL-6 and IL-8 promoters in B cell lines [21], and can also act as a dominant negative regulator of CEBPA and CEBPB in fibroblast and B cell lines [20].
T4956	17839-17844	NN	denotes	CEBPG
T4957	17848-17853	VBN	denotes	known
T4958	17845-17847	VBZ	denotes	is
T4959	17854-17856	TO	denotes	to
T4960	17857-17861	VB	denotes	have
T4961	17862-17873	JJ	denotes	stimulatory
T4962	17874-17880	NN	denotes	effect
T4963	17881-17883	IN	denotes	on
T4964	17884-17887	DT	denotes	the
T4965	17902-17911	NNS	denotes	promoters
T4966	17888-17890	NN	denotes	IL
T4967	17890-17891	HYPH	denotes	-
T4968	17891-17892	CD	denotes	6
T4969	17893-17896	CC	denotes	and
T4970	17897-17899	NN	denotes	IL
T4971	17899-17900	HYPH	denotes	-
T4972	17900-17901	CD	denotes	8
T4973	17912-17914	IN	denotes	in
T4974	17915-17916	NN	denotes	B
T4975	17917-17921	NN	denotes	cell
T4976	17922-17927	NNS	denotes	lines
T4977	17928-17929	-LRB-	denotes	[
T4978	17929-17931	CD	denotes	21
T4979	17931-17932	-RRB-	denotes	]
T4980	17932-17934	,	denotes	,
T4981	17934-17937	CC	denotes	and
T4982	17938-17941	MD	denotes	can
T4983	17947-17950	VB	denotes	act
T4984	17942-17946	RB	denotes	also
T4985	17951-17953	IN	denotes	as
T4986	17954-17955	DT	denotes	a
T4987	17974-17983	NN	denotes	regulator
T4988	17956-17964	JJ	denotes	dominant
T4989	17965-17973	JJ	denotes	negative
T4990	17984-17986	IN	denotes	of
T4991	17987-17992	NN	denotes	CEBPA
T4992	17993-17996	CC	denotes	and
T4993	17997-18002	NN	denotes	CEBPB
T4994	18003-18005	IN	denotes	in
T4995	18006-18016	NN	denotes	fibroblast
T4996	18028-18033	NNS	denotes	lines
T4997	18017-18020	CC	denotes	and
T4998	18021-18022	NN	denotes	B
T4999	18023-18027	NN	denotes	cell
T5000	18034-18035	-LRB-	denotes	[
T5001	18035-18037	CD	denotes	20
T5002	18037-18038	-RRB-	denotes	]
T5003	18038-18039	.	denotes	.
T5004	18039-18139	sentence	denotes	The data from CEBPG knockout mice support a role for CEBPG in protecting lungs from oxidant damage.
T5005	18040-18043	DT	denotes	The
T5006	18044-18048	NNS	denotes	data
T5007	18074-18081	VBP	denotes	support
T5008	18049-18053	IN	denotes	from
T5009	18054-18059	NN	denotes	CEBPG
T5010	18069-18073	NNS	denotes	mice
T5011	18060-18068	NN	denotes	knockout
T5012	18082-18083	DT	denotes	a
T5013	18084-18088	NN	denotes	role
T5014	18089-18092	IN	denotes	for
T5015	18093-18098	NN	denotes	CEBPG
T5016	18099-18101	IN	denotes	in
T5017	18102-18112	VBG	denotes	protecting
T5018	18113-18118	NNS	denotes	lungs
T5019	18119-18123	IN	denotes	from
T5020	18124-18131	NN	denotes	oxidant
T5021	18132-18138	NN	denotes	damage
T5022	18138-18139	.	denotes	.
T5023	18139-18280	sentence	denotes	CEBPG-/- knockout mice are healthy at birth but begin to die within 24 hours, and histological examination reveals emphysematous lungs [22].
T5024	18140-18145	NN	denotes	CEBPG
T5025	18149-18157	NN	denotes	knockout
T5026	18145-18146	SYM	denotes	-
T5027	18146-18147	HYPH	denotes	/
T5028	18147-18148	SYM	denotes	-
T5029	18158-18162	NNS	denotes	mice
T5030	18163-18166	VBP	denotes	are
T5031	18167-18174	JJ	denotes	healthy
T5032	18175-18177	IN	denotes	at
T5033	18178-18183	NN	denotes	birth
T5034	18184-18187	CC	denotes	but
T5035	18188-18193	VB	denotes	begin
T5036	18194-18196	TO	denotes	to
T5037	18197-18200	VB	denotes	die
T5038	18201-18207	IN	denotes	within
T5039	18208-18210	CD	denotes	24
T5040	18211-18216	NNS	denotes	hours
T5041	18216-18218	,	denotes	,
T5042	18218-18221	CC	denotes	and
T5043	18222-18234	JJ	denotes	histological
T5044	18235-18246	NN	denotes	examination
T5045	18247-18254	VBZ	denotes	reveals
T5046	18255-18268	JJ	denotes	emphysematous
T5047	18269-18274	NNS	denotes	lungs
T5048	18275-18276	-LRB-	denotes	[
T5049	18276-18278	CD	denotes	22
T5050	18278-18279	-RRB-	denotes	]
T5051	18279-18280	.	denotes	.
T5052	18280-18434	sentence	denotes	In humans, risk for emphysema is associated with antioxidant capacity [23], and there is a strong correlation between risk for emphysema and risk for BC.
T5053	18281-18283	IN	denotes	In
T5054	18314-18324	VBN	denotes	associated
T5055	18284-18290	NNS	denotes	humans
T5056	18290-18292	,	denotes	,
T5057	18292-18296	NN	denotes	risk
T5058	18297-18300	IN	denotes	for
T5059	18301-18310	NN	denotes	emphysema
T5060	18311-18313	VBZ	denotes	is
T5061	18325-18329	IN	denotes	with
T5062	18330-18341	NN	denotes	antioxidant
T5063	18342-18350	NN	denotes	capacity
T5064	18351-18352	-LRB-	denotes	[
T5065	18352-18354	CD	denotes	23
T5066	18354-18355	-RRB-	denotes	]
T5067	18355-18357	,	denotes	,
T5068	18357-18360	CC	denotes	and
T5069	18361-18366	EX	denotes	there
T5070	18367-18369	VBZ	denotes	is
T5071	18370-18371	DT	denotes	a
T5072	18379-18390	NN	denotes	correlation
T5073	18372-18378	JJ	denotes	strong
T5074	18391-18398	IN	denotes	between
T5075	18399-18403	NN	denotes	risk
T5076	18404-18407	IN	denotes	for
T5077	18408-18417	NN	denotes	emphysema
T5078	18418-18421	CC	denotes	and
T5079	18422-18426	NN	denotes	risk
T5080	18427-18430	IN	denotes	for
T5081	18431-18433	NN	denotes	BC
T5082	18433-18434	.	denotes	.
T5083	18434-18609	sentence	denotes	However, it will be important to obtain direct experimental evidence in NBECs for the role of CEBPG in regulating the antioxidant and DNA repair genes included in this study.
T5084	18435-18442	RB	denotes	However
T5085	18452-18454	VB	denotes	be
T5086	18442-18444	,	denotes	,
T5087	18444-18446	PRP	denotes	it
T5088	18447-18451	MD	denotes	will
T5089	18455-18464	JJ	denotes	important
T5090	18465-18467	TO	denotes	to
T5091	18468-18474	VB	denotes	obtain
T5092	18475-18481	JJ	denotes	direct
T5093	18495-18503	NN	denotes	evidence
T5094	18482-18494	JJ	denotes	experimental
T5095	18504-18506	IN	denotes	in
T5096	18507-18512	NNS	denotes	NBECs
T5097	18513-18516	IN	denotes	for
T5098	18517-18520	DT	denotes	the
T5099	18521-18525	NN	denotes	role
T5100	18526-18528	IN	denotes	of
T5101	18529-18534	NN	denotes	CEBPG
T5102	18535-18537	IN	denotes	in
T5103	18538-18548	VBG	denotes	regulating
T5104	18549-18552	DT	denotes	the
T5105	18580-18585	NNS	denotes	genes
T5106	18553-18564	NN	denotes	antioxidant
T5107	18565-18568	CC	denotes	and
T5108	18569-18572	NN	denotes	DNA
T5109	18573-18579	NN	denotes	repair
T5110	18586-18594	VBN	denotes	included
T5111	18595-18597	IN	denotes	in
T5112	18598-18602	DT	denotes	this
T5113	18603-18608	NN	denotes	study
T5114	18608-18609	.	denotes	.
T5115	18609-18730	sentence	denotes	Correlation between CEBPG and target gene transcript levels may not be associated with correlation at the protein level.
T5116	18610-18621	NN	denotes	Correlation
T5117	18681-18691	VBN	denotes	associated
T5118	18622-18629	IN	denotes	between
T5119	18630-18635	NN	denotes	CEBPG
T5120	18636-18639	CC	denotes	and
T5121	18640-18646	NN	denotes	target
T5122	18647-18651	NN	denotes	gene
T5123	18663-18669	NNS	denotes	levels
T5124	18652-18662	NN	denotes	transcript
T5125	18670-18673	MD	denotes	may
T5126	18674-18677	RB	denotes	not
T5127	18678-18680	VB	denotes	be
T5128	18692-18696	IN	denotes	with
T5129	18697-18708	NN	denotes	correlation
T5130	18709-18711	IN	denotes	at
T5131	18712-18715	DT	denotes	the
T5132	18724-18729	NN	denotes	level
T5133	18716-18723	NN	denotes	protein
T5134	18729-18730	.	denotes	.
T5135	18730-18943	sentence	denotes	In this study, E2F1 correlation with DNA repair and antioxidant genes was less than the correlation observed with CEBPG, and the E2F1 correlation was observed in both non-BC individuals as well as BC individuals.
T5136	18731-18733	IN	denotes	In
T5137	18801-18804	VBD	denotes	was
T5138	18734-18738	DT	denotes	this
T5139	18739-18744	NN	denotes	study
T5140	18744-18746	,	denotes	,
T5141	18746-18750	NN	denotes	E2F1
T5142	18751-18762	NN	denotes	correlation
T5143	18763-18767	IN	denotes	with
T5144	18768-18771	NN	denotes	DNA
T5145	18772-18778	NN	denotes	repair
T5146	18795-18800	NNS	denotes	genes
T5147	18779-18782	CC	denotes	and
T5148	18783-18794	NN	denotes	antioxidant
T5149	18805-18809	JJR	denotes	less
T5150	18810-18814	IN	denotes	than
T5151	18815-18818	DT	denotes	the
T5152	18819-18830	NN	denotes	correlation
T5153	18831-18839	VBN	denotes	observed
T5154	18840-18844	IN	denotes	with
T5155	18845-18850	NN	denotes	CEBPG
T5156	18850-18852	,	denotes	,
T5157	18852-18855	CC	denotes	and
T5158	18856-18859	DT	denotes	the
T5159	18865-18876	NN	denotes	correlation
T5160	18860-18864	NN	denotes	E2F1
T5161	18881-18889	VBN	denotes	observed
T5162	18877-18880	VBD	denotes	was
T5163	18890-18892	IN	denotes	in
T5164	18893-18897	CC	denotes	both
T5165	18905-18916	NNS	denotes	individuals
T5166	18898-18904	JJ	denotes	non-BC
T5167	18917-18919	RB	denotes	as
T5168	18925-18927	IN	denotes	as
T5169	18920-18924	RB	denotes	well
T5170	18928-18930	NN	denotes	BC
T5171	18931-18942	NNS	denotes	individuals
T5172	18942-18943	.	denotes	.
T5173	18943-19165	sentence	denotes	The maintained correlation of E2F1 with DNA repair and antioxidant genes in BC individuals suggests that this function is more tightly controlled in the population and does not play a role in determination of risk for BC.
T5174	18944-18947	DT	denotes	The
T5175	18959-18970	NN	denotes	correlation
T5176	18948-18958	VBN	denotes	maintained
T5177	19035-19043	VBZ	denotes	suggests
T5178	18971-18973	IN	denotes	of
T5179	18974-18978	NN	denotes	E2F1
T5180	18979-18983	IN	denotes	with
T5181	18984-18987	NN	denotes	DNA
T5182	18988-18994	NN	denotes	repair
T5183	19011-19016	NNS	denotes	genes
T5184	18995-18998	CC	denotes	and
T5185	18999-19010	NN	denotes	antioxidant
T5186	19017-19019	IN	denotes	in
T5187	19020-19022	NN	denotes	BC
T5188	19023-19034	NNS	denotes	individuals
T5189	19044-19048	IN	denotes	that
T5190	19079-19089	VBN	denotes	controlled
T5191	19049-19053	DT	denotes	this
T5192	19054-19062	NN	denotes	function
T5193	19063-19065	VBZ	denotes	is
T5194	19066-19070	RBR	denotes	more
T5195	19071-19078	RB	denotes	tightly
T5196	19090-19092	IN	denotes	in
T5197	19093-19096	DT	denotes	the
T5198	19097-19107	NN	denotes	population
T5199	19108-19111	CC	denotes	and
T5200	19112-19116	VBZ	denotes	does
T5201	19121-19125	VB	denotes	play
T5202	19117-19120	RB	denotes	not
T5203	19126-19127	DT	denotes	a
T5204	19128-19132	NN	denotes	role
T5205	19133-19135	IN	denotes	in
T5206	19136-19149	NN	denotes	determination
T5207	19150-19152	IN	denotes	of
T5208	19153-19157	NN	denotes	risk
T5209	19158-19161	IN	denotes	for
T5210	19162-19164	NN	denotes	BC
T5211	19164-19165	.	denotes	.
T5212	19165-19344	sentence	denotes	E2F1 has previously been reported to regulate transcription of DNA repair enzyme genes in other cell types, including primary human fibroblasts and mouse epidermal cells [24,25].
T5213	19166-19170	NN	denotes	E2F1
T5214	19191-19199	VBN	denotes	reported
T5215	19171-19174	VBZ	denotes	has
T5216	19175-19185	RB	denotes	previously
T5217	19186-19190	VBN	denotes	been
T5218	19200-19202	TO	denotes	to
T5219	19203-19211	VB	denotes	regulate
T5220	19212-19225	NN	denotes	transcription
T5221	19226-19228	IN	denotes	of
T5222	19229-19232	NN	denotes	DNA
T5223	19233-19239	NN	denotes	repair
T5224	19247-19252	NNS	denotes	genes
T5225	19240-19246	NN	denotes	enzyme
T5226	19253-19255	IN	denotes	in
T5227	19256-19261	JJ	denotes	other
T5228	19267-19272	NNS	denotes	types
T5229	19262-19266	NN	denotes	cell
T5230	19272-19274	,	denotes	,
T5231	19274-19283	VBG	denotes	including
T5232	19284-19291	JJ	denotes	primary
T5233	19298-19309	NNS	denotes	fibroblasts
T5234	19292-19297	JJ	denotes	human
T5235	19310-19313	CC	denotes	and
T5236	19314-19319	NN	denotes	mouse
T5237	19330-19335	NNS	denotes	cells
T5238	19320-19329	JJ	denotes	epidermal
T5239	19336-19337	-LRB-	denotes	[
T5240	19340-19342	CD	denotes	25
T5241	19337-19339	CD	denotes	24
T5242	19339-19340	,	denotes	,
T5243	19342-19343	-RRB-	denotes	]
T5244	19343-19344	.	denotes	.
T5245	19344-19540	sentence	denotes	Clearly this would have survival value since DNA repair gene up-regulation in response to E2F1 provides additional DNA repair when the DNA is replicating and is particularly vulnerable to damage.
T5246	19345-19352	RB	denotes	Clearly
T5247	19364-19368	VB	denotes	have
T5248	19353-19357	DT	denotes	this
T5249	19358-19363	MD	denotes	would
T5250	19369-19377	NN	denotes	survival
T5251	19378-19383	NN	denotes	value
T5252	19384-19389	IN	denotes	since
T5253	19440-19448	VBZ	denotes	provides
T5254	19390-19393	NN	denotes	DNA
T5255	19394-19400	NN	denotes	repair
T5256	19401-19405	NN	denotes	gene
T5257	19409-19419	NN	denotes	regulation
T5258	19406-19408	JJ	denotes	up
T5259	19408-19409	HYPH	denotes	-
T5260	19420-19422	IN	denotes	in
T5261	19423-19431	NN	denotes	response
T5262	19432-19434	IN	denotes	to
T5263	19435-19439	NN	denotes	E2F1
T5264	19449-19459	JJ	denotes	additional
T5265	19464-19470	NN	denotes	repair
T5266	19460-19463	NN	denotes	DNA
T5267	19471-19475	WRB	denotes	when
T5268	19487-19498	VBG	denotes	replicating
T5269	19476-19479	DT	denotes	the
T5270	19480-19483	NN	denotes	DNA
T5271	19484-19486	VBZ	denotes	is
T5272	19499-19502	CC	denotes	and
T5273	19503-19505	VBZ	denotes	is
T5274	19506-19518	RB	denotes	particularly
T5275	19519-19529	JJ	denotes	vulnerable
T5276	19530-19532	IN	denotes	to
T5277	19533-19539	NN	denotes	damage
T5278	19539-19540	.	denotes	.
T5279	19540-19710	sentence	denotes	Epidemiologic assessment of the correlation between a particular variation in DNA sequence, or polymorphism, and risk for BC has been a dominant paradigm for many years.
T5280	19541-19554	JJ	denotes	Epidemiologic
T5281	19555-19565	NN	denotes	assessment
T5282	19670-19674	VBN	denotes	been
T5283	19566-19568	IN	denotes	of
T5284	19569-19572	DT	denotes	the
T5285	19573-19584	NN	denotes	correlation
T5286	19585-19592	IN	denotes	between
T5287	19593-19594	DT	denotes	a
T5288	19606-19615	NN	denotes	variation
T5289	19595-19605	JJ	denotes	particular
T5290	19616-19618	IN	denotes	in
T5291	19619-19622	NN	denotes	DNA
T5292	19623-19631	NN	denotes	sequence
T5293	19631-19633	,	denotes	,
T5294	19633-19635	CC	denotes	or
T5295	19636-19648	NN	denotes	polymorphism
T5296	19648-19650	,	denotes	,
T5297	19650-19653	CC	denotes	and
T5298	19654-19658	NN	denotes	risk
T5299	19659-19662	IN	denotes	for
T5300	19663-19665	NN	denotes	BC
T5301	19666-19669	VBZ	denotes	has
T5302	19675-19676	DT	denotes	a
T5303	19686-19694	NN	denotes	paradigm
T5304	19677-19685	JJ	denotes	dominant
T5305	19695-19698	IN	denotes	for
T5306	19699-19703	JJ	denotes	many
T5307	19704-19709	NNS	denotes	years
T5308	19709-19710	.	denotes	.
T5309	19710-19768	sentence	denotes	Thus far, these efforts have met with scant success [26].
T5310	19711-19715	RB	denotes	Thus
T5311	19716-19719	RB	denotes	far
T5312	19740-19743	VBN	denotes	met
T5313	19719-19721	,	denotes	,
T5314	19721-19726	DT	denotes	these
T5315	19727-19734	NNS	denotes	efforts
T5316	19735-19739	VBP	denotes	have
T5317	19744-19748	IN	denotes	with
T5318	19749-19754	JJ	denotes	scant
T5319	19755-19762	NN	denotes	success
T5320	19763-19764	-LRB-	denotes	[
T5321	19764-19766	CD	denotes	26
T5322	19766-19767	-RRB-	denotes	]
T5323	19767-19768	.	denotes	.
T5324	19768-19909	sentence	denotes	A common limitation in design of such studies is that they involve assessment of a single polymorphism or occasionally, a few polymorphisms.
T5325	19769-19770	DT	denotes	A
T5326	19778-19788	NN	denotes	limitation
T5327	19771-19777	JJ	denotes	common
T5328	19815-19817	VBZ	denotes	is
T5329	19789-19791	IN	denotes	in
T5330	19792-19798	NN	denotes	design
T5331	19799-19801	IN	denotes	of
T5332	19802-19806	JJ	denotes	such
T5333	19807-19814	NNS	denotes	studies
T5334	19818-19822	IN	denotes	that
T5335	19828-19835	VBP	denotes	involve
T5336	19823-19827	PRP	denotes	they
T5337	19836-19846	NN	denotes	assessment
T5338	19847-19849	IN	denotes	of
T5339	19850-19851	DT	denotes	a
T5340	19859-19871	NN	denotes	polymorphism
T5341	19852-19858	JJ	denotes	single
T5342	19872-19874	CC	denotes	or
T5343	19875-19887	RB	denotes	occasionally
T5344	19895-19908	NNS	denotes	polymorphisms
T5345	19887-19889	,	denotes	,
T5346	19889-19890	DT	denotes	a
T5347	19891-19894	JJ	denotes	few
T5348	19908-19909	.	denotes	.
T5349	19909-20187	sentence	denotes	Further, although the polymorphism assessed typically resides within a gene known to protect bronchial epithelium from carcinogens, oxidants, or DNA damage, the selection of the particular polymorphism for study is largely empiric, and not based on known functional properties.
T5350	19910-19917	RB	denotes	Further
T5351	20122-20124	VBZ	denotes	is
T5352	19917-19919	,	denotes	,
T5353	19919-19927	IN	denotes	although
T5354	19964-19971	VBZ	denotes	resides
T5355	19928-19931	DT	denotes	the
T5356	19932-19944	NN	denotes	polymorphism
T5357	19945-19953	VBN	denotes	assessed
T5358	19954-19963	RB	denotes	typically
T5359	19972-19978	IN	denotes	within
T5360	19979-19980	DT	denotes	a
T5361	19981-19985	NN	denotes	gene
T5362	19986-19991	VBN	denotes	known
T5363	19992-19994	TO	denotes	to
T5364	19995-20002	VB	denotes	protect
T5365	20003-20012	JJ	denotes	bronchial
T5366	20013-20023	NN	denotes	epithelium
T5367	20024-20028	IN	denotes	from
T5368	20029-20040	NNS	denotes	carcinogens
T5369	20040-20042	,	denotes	,
T5370	20042-20050	NNS	denotes	oxidants
T5371	20050-20052	,	denotes	,
T5372	20052-20054	CC	denotes	or
T5373	20055-20058	NN	denotes	DNA
T5374	20059-20065	NN	denotes	damage
T5375	20065-20067	,	denotes	,
T5376	20067-20070	DT	denotes	the
T5377	20071-20080	NN	denotes	selection
T5378	20081-20083	IN	denotes	of
T5379	20084-20087	DT	denotes	the
T5380	20099-20111	NN	denotes	polymorphism
T5381	20088-20098	JJ	denotes	particular
T5382	20112-20115	IN	denotes	for
T5383	20116-20121	NN	denotes	study
T5384	20125-20132	RB	denotes	largely
T5385	20133-20140	JJ	denotes	empiric
T5386	20140-20142	,	denotes	,
T5387	20142-20145	CC	denotes	and
T5388	20146-20149	RB	denotes	not
T5389	20150-20155	VBN	denotes	based
T5390	20156-20158	IN	denotes	on
T5391	20159-20164	JJ	denotes	known
T5392	20176-20186	NNS	denotes	properties
T5393	20165-20175	JJ	denotes	functional
T5394	20186-20187	.	denotes	.
T5395	20187-20455	sentence	denotes	These are problems because multiple infrequent polymorphisms at different sites may all contribute to risk and unless the key polymorphisms can be identified through a functional test, a statistically valid assessment would require much larger study populations [27].
T5396	20188-20193	DT	denotes	These
T5397	20194-20197	VBP	denotes	are
T5398	20198-20206	NNS	denotes	problems
T5399	20207-20214	IN	denotes	because
T5400	20276-20286	VB	denotes	contribute
T5401	20215-20223	JJ	denotes	multiple
T5402	20235-20248	NNS	denotes	polymorphisms
T5403	20224-20234	JJ	denotes	infrequent
T5404	20249-20251	IN	denotes	at
T5405	20252-20261	JJ	denotes	different
T5406	20262-20267	NNS	denotes	sites
T5407	20268-20271	MD	denotes	may
T5408	20272-20275	RB	denotes	all
T5409	20287-20289	IN	denotes	to
T5410	20290-20294	NN	denotes	risk
T5411	20295-20298	CC	denotes	and
T5412	20299-20305	IN	denotes	unless
T5413	20335-20345	VBN	denotes	identified
T5414	20306-20309	DT	denotes	the
T5415	20314-20327	NNS	denotes	polymorphisms
T5416	20310-20313	JJ	denotes	key
T5417	20328-20331	MD	denotes	can
T5418	20332-20334	VB	denotes	be
T5419	20412-20419	VB	denotes	require
T5420	20346-20353	IN	denotes	through
T5421	20354-20355	DT	denotes	a
T5422	20367-20371	NN	denotes	test
T5423	20356-20366	JJ	denotes	functional
T5424	20371-20373	,	denotes	,
T5425	20373-20374	DT	denotes	a
T5426	20395-20405	NN	denotes	assessment
T5427	20375-20388	RB	denotes	statistically
T5428	20389-20394	JJ	denotes	valid
T5429	20406-20411	MD	denotes	would
T5430	20420-20424	RB	denotes	much
T5431	20425-20431	JJR	denotes	larger
T5432	20438-20449	NNS	denotes	populations
T5433	20432-20437	NN	denotes	study
T5434	20450-20451	-LRB-	denotes	[
T5435	20451-20453	CD	denotes	27
T5436	20453-20454	-RRB-	denotes	]
T5437	20454-20455	.	denotes	.
T5438	20455-20552	sentence	denotes	The findings of this study support a novel approach to identifying clinically useful biomarkers.
T5439	20456-20459	DT	denotes	The
T5440	20460-20468	NNS	denotes	findings
T5441	20483-20490	VBP	denotes	support
T5442	20469-20471	IN	denotes	of
T5443	20472-20476	DT	denotes	this
T5444	20477-20482	NN	denotes	study
T5445	20491-20492	DT	denotes	a
T5446	20499-20507	NN	denotes	approach
T5447	20493-20498	JJ	denotes	novel
T5448	20508-20510	IN	denotes	to
T5449	20511-20522	VBG	denotes	identifying
T5450	20523-20533	RB	denotes	clinically
T5451	20534-20540	JJ	denotes	useful
T5452	20541-20551	NNS	denotes	biomarkers
T5453	20551-20552	.	denotes	.
T5454	20552-20953	sentence	denotes	According to the paradigm used in this study, a) a normal phenotype results from regulated transcription of a group of genes by one or more transcription factors, b) the corresponding risk-conferring or disease phenotype results from sub-optimal interaction among those same genes, and c) each phenotype is identifiable and distinguishable through virtually-multiplexed transcript abundance analysis.
T5455	20553-20562	VBG	denotes	According
T5456	20621-20628	VBZ	denotes	results
T5457	20563-20565	IN	denotes	to
T5458	20566-20569	DT	denotes	the
T5459	20570-20578	NN	denotes	paradigm
T5460	20579-20583	VBN	denotes	used
T5461	20584-20586	IN	denotes	in
T5462	20587-20591	DT	denotes	this
T5463	20592-20597	NN	denotes	study
T5464	20597-20599	,	denotes	,
T5465	20599-20600	LS	denotes	a
T5466	20600-20601	-RRB-	denotes	)
T5467	20602-20603	DT	denotes	a
T5468	20611-20620	NN	denotes	phenotype
T5469	20604-20610	JJ	denotes	normal
T5470	20629-20633	IN	denotes	from
T5471	20634-20643	VBN	denotes	regulated
T5472	20644-20657	NN	denotes	transcription
T5473	20658-20660	IN	denotes	of
T5474	20661-20662	DT	denotes	a
T5475	20663-20668	NN	denotes	group
T5476	20669-20671	IN	denotes	of
T5477	20672-20677	NNS	denotes	genes
T5478	20678-20680	IN	denotes	by
T5479	20681-20684	CD	denotes	one
T5480	20707-20714	NNS	denotes	factors
T5481	20685-20687	CC	denotes	or
T5482	20688-20692	JJR	denotes	more
T5483	20693-20706	NN	denotes	transcription
T5484	20714-20716	,	denotes	,
T5485	20716-20717	LS	denotes	b
T5486	20774-20781	VBZ	denotes	results
T5487	20717-20718	-RRB-	denotes	)
T5488	20719-20722	DT	denotes	the
T5489	20764-20773	NN	denotes	phenotype
T5490	20723-20736	VBG	denotes	corresponding
T5491	20737-20741	NN	denotes	risk
T5492	20742-20752	VBG	denotes	conferring
T5493	20741-20742	HYPH	denotes	-
T5494	20753-20755	CC	denotes	or
T5495	20756-20763	NN	denotes	disease
T5496	20782-20786	IN	denotes	from
T5497	20787-20798	JJ	denotes	sub-optimal
T5498	20799-20810	NN	denotes	interaction
T5499	20811-20816	IN	denotes	among
T5500	20817-20822	DT	denotes	those
T5501	20828-20833	NNS	denotes	genes
T5502	20823-20827	JJ	denotes	same
T5503	20833-20835	,	denotes	,
T5504	20835-20838	CC	denotes	and
T5505	20839-20840	LS	denotes	c
T5506	20857-20859	VBZ	denotes	is
T5507	20840-20841	-RRB-	denotes	)
T5508	20842-20846	DT	denotes	each
T5509	20847-20856	NN	denotes	phenotype
T5510	20860-20872	JJ	denotes	identifiable
T5511	20873-20876	CC	denotes	and
T5512	20877-20892	JJ	denotes	distinguishable
T5513	20893-20900	IN	denotes	through
T5514	20901-20910	RB	denotes	virtually
T5515	20911-20922	VBN	denotes	multiplexed
T5516	20910-20911	HYPH	denotes	-
T5517	20944-20952	NN	denotes	analysis
T5518	20923-20933	NN	denotes	transcript
T5519	20934-20943	NN	denotes	abundance
T5520	20952-20953	.	denotes	.
T5521	20953-21064	sentence	denotes	The data presented here support the utility of this paradigm in identifying genes associated with risk for BC.
T5522	20954-20957	DT	denotes	The
T5523	20958-20962	NNS	denotes	data
T5524	20978-20985	VBP	denotes	support
T5525	20963-20972	VBN	denotes	presented
T5526	20973-20977	RB	denotes	here
T5527	20986-20989	DT	denotes	the
T5528	20990-20997	NN	denotes	utility
T5529	20998-21000	IN	denotes	of
T5530	21001-21005	DT	denotes	this
T5531	21006-21014	NN	denotes	paradigm
T5532	21015-21017	IN	denotes	in
T5533	21018-21029	VBG	denotes	identifying
T5534	21030-21035	NNS	denotes	genes
T5535	21036-21046	VBN	denotes	associated
T5536	21047-21051	IN	denotes	with
T5537	21052-21056	NN	denotes	risk
T5538	21057-21060	IN	denotes	for
T5539	21061-21063	NN	denotes	BC
T5540	21063-21064	.	denotes	.
T5541	21064-21184	sentence	denotes	The next step will be to identify polymorphisms that affect regulation of XRCC1, ERCC5, GSTP1, SOD1, and GPX1 by CEBPG.
T5542	21065-21068	DT	denotes	The
T5543	21074-21078	NN	denotes	step
T5544	21069-21073	JJ	denotes	next
T5545	21084-21086	VB	denotes	be
T5546	21079-21083	MD	denotes	will
T5547	21087-21089	TO	denotes	to
T5548	21090-21098	VB	denotes	identify
T5549	21099-21112	NNS	denotes	polymorphisms
T5550	21113-21117	WDT	denotes	that
T5551	21118-21124	VBP	denotes	affect
T5552	21125-21135	NN	denotes	regulation
T5553	21136-21138	IN	denotes	of
T5554	21139-21144	NN	denotes	XRCC1
T5555	21144-21146	,	denotes	,
T5556	21146-21151	NN	denotes	ERCC5
T5557	21151-21153	,	denotes	,
T5558	21153-21158	NN	denotes	GSTP1
T5559	21158-21160	,	denotes	,
T5560	21160-21164	NN	denotes	SOD1
T5561	21164-21166	,	denotes	,
T5562	21166-21169	CC	denotes	and
T5563	21170-21174	NN	denotes	GPX1
T5564	21175-21177	IN	denotes	by
T5565	21178-21183	NN	denotes	CEBPG
T5566	21183-21184	.	denotes	.
T5567	21184-21316	sentence	denotes	Such polymorphisms should yield biomarkers suitable for more readily accessible samples, such as peripheral blood or buccal smears.
T5568	21185-21189	JJ	denotes	Such
T5569	21190-21203	NNS	denotes	polymorphisms
T5570	21211-21216	VB	denotes	yield
T5571	21204-21210	MD	denotes	should
T5572	21217-21227	NNS	denotes	biomarkers
T5573	21228-21236	JJ	denotes	suitable
T5574	21237-21240	IN	denotes	for
T5575	21241-21245	RBR	denotes	more
T5576	21246-21253	RB	denotes	readily
T5577	21254-21264	JJ	denotes	accessible
T5578	21265-21272	NNS	denotes	samples
T5579	21272-21274	,	denotes	,
T5580	21274-21278	JJ	denotes	such
T5581	21279-21281	IN	denotes	as
T5582	21282-21292	JJ	denotes	peripheral
T5583	21293-21298	NN	denotes	blood
T5584	21299-21301	CC	denotes	or
T5585	21302-21308	JJ	denotes	buccal
T5586	21309-21315	NNS	denotes	smears
T5587	21315-21316	.	denotes	.
T5588	21316-21521	sentence	denotes	A biomarker combining polymorphisms that affect regulation with those that affect function of antioxidant and DNA repair genes is likely to be the most accurate for identifying individuals at risk for BC.
T5589	21317-21318	DT	denotes	A
T5590	21319-21328	NN	denotes	biomarker
T5591	21444-21446	VBZ	denotes	is
T5592	21329-21338	VBG	denotes	combining
T5593	21339-21352	NNS	denotes	polymorphisms
T5594	21353-21357	WDT	denotes	that
T5595	21358-21364	VBP	denotes	affect
T5596	21365-21375	NN	denotes	regulation
T5597	21376-21380	IN	denotes	with
T5598	21381-21386	DT	denotes	those
T5599	21387-21391	WDT	denotes	that
T5600	21392-21398	VBP	denotes	affect
T5601	21399-21407	NN	denotes	function
T5602	21408-21410	IN	denotes	of
T5603	21411-21422	NN	denotes	antioxidant
T5604	21438-21443	NNS	denotes	genes
T5605	21423-21426	CC	denotes	and
T5606	21427-21430	NN	denotes	DNA
T5607	21431-21437	NN	denotes	repair
T5608	21447-21453	JJ	denotes	likely
T5609	21454-21456	TO	denotes	to
T5610	21457-21459	VB	denotes	be
T5611	21460-21463	DT	denotes	the
T5612	21469-21477	JJ	denotes	accurate
T5613	21464-21468	RBS	denotes	most
T5614	21478-21481	IN	denotes	for
T5615	21482-21493	VBG	denotes	identifying
T5616	21494-21505	NNS	denotes	individuals
T5617	21506-21508	IN	denotes	at
T5618	21509-21513	NN	denotes	risk
T5619	21514-21517	IN	denotes	for
T5620	21518-21520	NN	denotes	BC
T5621	21520-21521	.	denotes	.
T5622	21521-21662	sentence	denotes	Biomarkers that accurately identify individuals at risk for BC will improve efficacy of chemoprevention and early detection clinical trials.
T5623	21522-21532	NNS	denotes	Biomarkers
T5624	21590-21597	VB	denotes	improve
T5625	21533-21537	WDT	denotes	that
T5626	21549-21557	VBP	denotes	identify
T5627	21538-21548	RB	denotes	accurately
T5628	21558-21569	NNS	denotes	individuals
T5629	21570-21572	IN	denotes	at
T5630	21573-21577	NN	denotes	risk
T5631	21578-21581	IN	denotes	for
T5632	21582-21584	NN	denotes	BC
T5633	21585-21589	MD	denotes	will
T5634	21598-21606	NN	denotes	efficacy
T5635	21607-21609	IN	denotes	of
T5636	21610-21625	NN	denotes	chemoprevention
T5637	21626-21629	CC	denotes	and
T5638	21630-21635	JJ	denotes	early
T5639	21636-21645	NN	denotes	detection
T5640	21655-21661	NNS	denotes	trials
T5641	21646-21654	JJ	denotes	clinical
T5642	21661-21662	.	denotes	.
T5643	21662-21884	sentence	denotes	The observed inter-sample variation in the presence of gene-specific inhibitors of PCR provides evidence supporting the need for inclusion of an internal standard in each quantitative PCR transcript abundance measurement.
T5644	21663-21666	DT	denotes	The
T5645	21689-21698	NN	denotes	variation
T5646	21667-21675	VBN	denotes	observed
T5647	21676-21688	JJ	denotes	inter-sample
T5648	21750-21758	VBZ	denotes	provides
T5649	21699-21701	IN	denotes	in
T5650	21702-21705	DT	denotes	the
T5651	21706-21714	NN	denotes	presence
T5652	21715-21717	IN	denotes	of
T5653	21718-21722	NN	denotes	gene
T5654	21723-21731	JJ	denotes	specific
T5655	21722-21723	HYPH	denotes	-
T5656	21732-21742	NNS	denotes	inhibitors
T5657	21743-21745	IN	denotes	of
T5658	21746-21749	NN	denotes	PCR
T5659	21759-21767	NN	denotes	evidence
T5660	21768-21778	VBG	denotes	supporting
T5661	21779-21782	DT	denotes	the
T5662	21783-21787	NN	denotes	need
T5663	21788-21791	IN	denotes	for
T5664	21792-21801	NN	denotes	inclusion
T5665	21802-21804	IN	denotes	of
T5666	21805-21807	DT	denotes	an
T5667	21817-21825	NN	denotes	standard
T5668	21808-21816	JJ	denotes	internal
T5669	21826-21828	IN	denotes	in
T5670	21829-21833	DT	denotes	each
T5671	21872-21883	NN	denotes	measurement
T5672	21834-21846	JJ	denotes	quantitative
T5673	21847-21850	NN	denotes	PCR
T5674	21851-21861	NN	denotes	transcript
T5675	21862-21871	NN	denotes	abundance
T5676	21883-21884	.	denotes	.
T5677	21884-22153	sentence	denotes	Including such internal standards in the form of standardized mixtures of internal standards improves the reproducibility of transcript abundance measurement and enables development of a standardized database comprising virtually-multiplexed transcript abundance data.
T5678	21885-21894	VBG	denotes	Including
T5679	21978-21986	VBZ	denotes	improves
T5680	21895-21899	JJ	denotes	such
T5681	21909-21918	NNS	denotes	standards
T5682	21900-21908	JJ	denotes	internal
T5683	21919-21921	IN	denotes	in
T5684	21922-21925	DT	denotes	the
T5685	21926-21930	NN	denotes	form
T5686	21931-21933	IN	denotes	of
T5687	21934-21946	JJ	denotes	standardized
T5688	21947-21955	NNS	denotes	mixtures
T5689	21956-21958	IN	denotes	of
T5690	21959-21967	JJ	denotes	internal
T5691	21968-21977	NNS	denotes	standards
T5692	21987-21990	DT	denotes	the
T5693	21991-22006	NN	denotes	reproducibility
T5694	22007-22009	IN	denotes	of
T5695	22010-22020	NN	denotes	transcript
T5696	22021-22030	NN	denotes	abundance
T5697	22031-22042	NN	denotes	measurement
T5698	22043-22046	CC	denotes	and
T5699	22047-22054	VBZ	denotes	enables
T5700	22055-22066	NN	denotes	development
T5701	22067-22069	IN	denotes	of
T5702	22070-22071	DT	denotes	a
T5703	22085-22093	NN	denotes	database
T5704	22072-22084	VBN	denotes	standardized
T5705	22094-22104	VBG	denotes	comprising
T5735	22297-22308	NN	denotes	Correlation
T5736	22343-22345	VBZ	denotes	is
T5737	22309-22311	IN	denotes	at
T5738	22312-22315	DT	denotes	the
T5739	22337-22342	NN	denotes	level
T5740	22316-22326	NN	denotes	transcript
T5741	22327-22336	NN	denotes	abundance
T5742	22346-22348	DT	denotes	an
T5743	22359-22367	NN	denotes	property
T5744	22349-22358	JJ	denotes	important
T5745	22368-22370	IN	denotes	of
T5746	22371-22376	NNS	denotes	genes
T5747	22377-22381	WDT	denotes	that
T5748	22386-22398	VBN	denotes	co-regulated
T5749	22382-22385	VBP	denotes	are
T5750	22399-22401	IN	denotes	at
T5751	22402-22405	DT	denotes	the
T5752	22420-22425	NN	denotes	level
T5753	22406-22419	NN	denotes	transcription
T5754	22425-22426	.	denotes	.
T5794	22439-22441	PRP	denotes	We
T5795	22442-22450	VBP	denotes	conclude
T5796	22451-22455	IN	denotes	that
T5797	22485-22494	VBZ	denotes	regulates
T5798	22456-22458	IN	denotes	in
T5799	22459-22465	JJ	denotes	non-BC
T5800	22466-22477	NNS	denotes	individuals
T5801	22477-22479	,	denotes	,
T5802	22479-22484	NN	denotes	CEBPG
T5803	22495-22508	NN	denotes	transcription
T5804	22509-22511	IN	denotes	of
T5805	22512-22515	JJ	denotes	key
T5806	22542-22547	NNS	denotes	genes
T5807	22516-22527	NN	denotes	antioxidant
T5808	22528-22530	CC	denotes	or
T5809	22531-22534	NN	denotes	DNA
T5810	22535-22541	NN	denotes	repair
T5811	22548-22550	IN	denotes	in
T5812	22551-22555	NN	denotes	NBEC
T5813	22556-22559	CC	denotes	and
T5814	22560-22564	IN	denotes	that
T5815	22609-22611	VBZ	denotes	is
T5816	22565-22567	IN	denotes	in
T5817	22568-22575	NNS	denotes	smokers
T5818	22576-22579	WP	denotes	who
T5819	22580-22587	VBP	denotes	develop
T5820	22588-22590	NN	denotes	BC
T5821	22590-22592	,	denotes	,
T5822	22592-22597	NN	denotes	CEBPG
T5823	22598-22608	NN	denotes	regulation
T5824	22612-22623	JJ	denotes	sub-optimal
T5825	22624-22627	IN	denotes	for
T5826	22690-22695	VB	denotes	cause
T5827	22628-22629	DT	denotes	a
T5828	22641-22647	NN	denotes	number
T5829	22630-22640	JJ	denotes	sufficient
T5830	22648-22650	IN	denotes	of
T5831	22651-22662	NN	denotes	antioxidant
T5832	22681-22686	NNS	denotes	genes
T5833	22663-22666	CC	denotes	and
T5834	22666-22667	HYPH	denotes	/
T5835	22667-22669	CC	denotes	or
T5836	22670-22673	NN	denotes	DNA
T5837	22674-22680	NN	denotes	repair
T5838	22687-22689	TO	denotes	to
T5839	22696-22705	VBN	denotes	increased
T5840	22706-22710	NN	denotes	risk
T5841	22710-22711	.	denotes	.
T5842	23570-23573	DT	denotes	The
T5843	23590-23597	NN	denotes	history
T5844	23574-23589	JJ	denotes	pre-publication
T5845	23620-23628	VBN	denotes	accessed
T5846	23598-23601	IN	denotes	for
T5847	23602-23606	DT	denotes	this
T5848	23607-23612	NN	denotes	paper
T5849	23613-23616	MD	denotes	can
T5850	23617-23619	VB	denotes	be
T5851	23629-23633	RB	denotes	here
T5852	23633-23634	:	denotes	:
T265	0-5	NN	denotes	CEBPG
T5706	22105-22114	RB	denotes	virtually
T5707	22115-22126	VBN	denotes	multiplexed
T5708	22114-22115	HYPH	denotes	-
T5709	22148-22152	NNS	denotes	data
T5710	22127-22137	NN	denotes	transcript
T5711	22138-22147	NN	denotes	abundance
T5712	22152-22153	.	denotes	.
T5713	22153-22296	sentence	denotes	Virtually-multiplexed transcript abundance data are highly suited to identification of genes that have correlated transcript abundance values.
T5714	22154-22163	RB	denotes	Virtually
T5715	22164-22175	VBN	denotes	multiplexed
T5716	22163-22164	HYPH	denotes	-
T5717	22197-22201	NNS	denotes	data
T5718	22176-22186	NN	denotes	transcript
T5719	22187-22196	NN	denotes	abundance
T5720	22202-22205	VBP	denotes	are
T5721	22206-22212	RB	denotes	highly
T5722	22213-22219	JJ	denotes	suited
T5723	22220-22222	IN	denotes	to
T5724	22223-22237	NN	denotes	identification
T5725	22238-22240	IN	denotes	of
T5726	22241-22246	NNS	denotes	genes
T5727	22247-22251	WDT	denotes	that
T5728	22252-22256	VBP	denotes	have
T5729	22257-22267	VBN	denotes	correlated
T5730	22289-22295	NNS	denotes	values
T5731	22268-22278	NN	denotes	transcript
T5732	22279-22288	NN	denotes	abundance
T5733	22295-22296	.	denotes	.
T5734	22296-22426	sentence	denotes	Correlation at the transcript abundance level is an important property of genes that are co-regulated at the transcription level.
R94	T370	T371	det	the,samples
R95	T371	T369	pobj	samples,of
R1	T266	T269	nsubj	factor,correlates
R3	T270	T269	prep	with,correlates
R4	T271	T272	nmod	antioxidant,genes
R5	T272	T270	pobj	genes,with
R9	T276	T269	prep	in,correlates
R10	T277	T278	amod	normal,cells
R11	T278	T276	pobj	cells,in
R14	T281	T276	cc	but,in
R15	T282	T281	neg	not,but
R16	T283	T276	conj	in,in
R17	T284	T283	pobj	individuals,in
R18	T285	T284	prep	with,individuals
R19	T286	T287	amod	bronchogenic,carcinoma
R20	T287	T285	pobj	carcinoma,with
R21	T292	T293	compound	Cigarette,smoking
R22	T293	T294	nsubj	smoking,is
R23	T295	T296	det	the,cause
R24	T296	T294	attr	cause,is
R26	T298	T296	prep	of,cause
R27	T299	T300	amod	bronchogenic,carcinoma
R28	T300	T298	pobj	carcinoma,of
R29	T301	T300	punct	(,carcinoma
R30	T302	T300	appos	BC,carcinoma
R31	T303	T294	punct	),is
R32	T304	T294	punct	", ",is
R33	T305	T294	cc	yet,is
R34	T306	T307	advmod	only,15
R35	T307	T310	nummod	15,%
R38	T310	T311	nsubj	%,develop
R39	T311	T294	conj	develop,is
R43	T315	T311	dobj	BC,develop
R44	T316	T311	cc	and,develop
R45	T317	T318	nsubj	it,is
R46	T318	T311	conj	is,develop
R47	T319	T318	acomp	likely,is
R48	T320	T321	mark	that,determined
R49	T321	T318	ccomp	determined,is
R60	T332	T311	punct	.,develop
R61	T334	T335	nsubj	We,reported
R62	T336	T335	advmod	previously,reported
R63	T337	T338	det	a,set
R64	T338	T335	dobj	set,reported
R65	T339	T338	prep	of,set
R66	T340	T341	compound	antioxidant,genes
R67	T341	T339	pobj	genes,of
R68	T342	T343	prep	for,was
R69	T343	T341	relcl	was,genes
R73	T347	T343	acomp	lower,was
R74	T348	T343	prep	in,was
R75	T349	T350	amod	normal,cells
R76	T350	T348	pobj	cells,in
R79	T353	T350	punct	(,cells
R80	T354	T350	appos	NBEC,cells
R81	T355	T350	punct	),cells
R82	T356	T350	prep	of,cells
R83	T357	T358	compound	BC,individuals
R84	T358	T356	pobj	individuals,of
R85	T359	T343	prep	compared,was
R86	T360	T359	prep	to,compared
R87	T361	T362	amod	non-BC,individuals
R88	T362	T360	pobj	individuals,to
R89	T363	T335	punct	.,reported
R90	T365	T366	prep	In,correlated
R91	T367	T368	amod	unpublished,studies
R92	T368	T365	pobj	studies,In
R93	T369	T368	prep	of,studies
R98	T374	T366	punct	", ",correlated
R99	T375	T376	compound	transcript,values
R100	T376	T366	nsubjpass	values,correlated
R102	T378	T376	prep	for,values
R103	T379	T380	amod	several,genes
R104	T380	T378	pobj	genes,for
R107	T383	T366	auxpass	were,correlated
R108	T384	T366	prep	with,correlated
R109	T385	T386	det	these,genes
R110	T386	T384	pobj	genes,with
R112	T388	T366	punct	.,correlated
R113	T390	T391	prep	From,hypothesized
R114	T392	T393	det	these,data
R115	T393	T390	pobj	data,From
R116	T394	T391	punct	", ",hypothesized
R117	T395	T391	nsubj	we,hypothesized
R118	T396	T397	mark	that,co-regulated
R119	T397	T391	advcl	co-regulated,hypothesized
R121	T399	T397	nsubjpass	genes,co-regulated
R122	T400	T398	cc	and,antioxidant
R123	T401	T402	compound	DNA,repair
R124	T402	T398	conj	repair,antioxidant
R126	T404	T397	agent	by,co-regulated
R127	T405	T406	nummod	one,factors
R128	T406	T404	pobj	factors,by
R132	T410	T397	cc	and,co-regulated
R133	T411	T412	mark	that,is
R134	T412	T397	conj	is,co-regulated
R149	T427	T425	pobj	factors,of
R150	T428	T427	compound	transcription,factors
R151	T429	T412	acomp	responsible,is
R152	T430	T429	prep	for,responsible
R153	T431	T432	amod	inter-individual,variation
R154	T432	T430	pobj	variation,for
R155	T433	T432	prep	in,variation
R156	T434	T433	pobj	risk,in
R157	T435	T434	prep	for,risk
R158	T436	T435	pobj	BC,for
R159	T437	T391	punct	.,hypothesized
R160	T441	T442	det	The,sites
R161	T442	T447	nsubjpass	sites,identified
R166	T448	T442	amod	common,sites
R167	T449	T448	prep	to,common
R168	T450	T449	pobj	six,to
R169	T451	T450	prep	of,six
R170	T452	T453	det	the,genes
R171	T453	T451	pobj	genes,of
R173	T455	T447	auxpass	were,identified
R174	T456	T447	prep	through,identified
R175	T457	T458	advmod	in,silico
R176	T458	T459	amod	silico,analysis
R177	T459	T456	pobj	analysis,through
R180	T462	T447	punct	.,identified
R181	T464	T465	det	The,values
R182	T465	T468	nsubjpass	values,measured
R185	T469	T465	prep	of,values
R186	T470	T471	det	these,factors
R187	T471	T469	pobj	factors,of
R189	T473	T474	punct	(,6
R190	T474	T465	parataxis	6,values
R193	T477	T474	punct	),6
R194	T478	T465	cc	and,values
R195	T479	T480	det	an,group
R196	T480	T465	conj	group,values
R198	T482	T480	prep	of,group
R199	T483	T484	nmod	antioxidant,genes
R200	T484	T482	pobj	genes,of
R204	T488	T489	punct	(,16
R205	T489	T480	parataxis	16,group
R208	T492	T489	punct	),16
R209	T493	T468	auxpass	were,measured
R210	T494	T468	advmod	simultaneously,measured
R211	T495	T468	prep	by,measured
R212	T496	T497	amod	quantitative,PCR
R213	T497	T495	pobj	PCR,by
R214	T498	T468	prep	in,measured
R215	T499	T498	pobj	NBEC,in
R216	T500	T499	prep	of,NBEC
R217	T501	T500	pobj	24,of
R218	T502	T501	amod	non-BC,24
R219	T503	T501	cc	and,24
R220	T504	T505	nummod	25,BC
R221	T505	T506	compound	BC,individuals
R222	T506	T501	conj	individuals,24
R223	T507	T468	punct	.,measured
R224	T511	T512	compound	CEBPG,factor
R225	T512	T514	nsubjpass	factor,correlated
R227	T515	T514	auxpass	was,correlated
R228	T516	T514	advmod	significantly,correlated
R229	T517	T518	punct	(,0.01
R230	T518	T516	parataxis	0.01,significantly
R233	T521	T518	punct	),0.01
R234	T522	T514	prep	with,correlated
R235	T523	T522	pobj	eight,with
R236	T524	T523	prep	of,eight
R237	T525	T526	det	the,genes
R238	T526	T524	pobj	genes,of
R243	T531	T514	prep	in,correlated
R244	T532	T533	amod	non-BC,individuals
R245	T533	T531	pobj	individuals,in
R246	T534	T531	cc	but,in
R247	T535	T534	neg	not,but
R248	T536	T531	conj	in,in
R249	T537	T538	compound	BC,individuals
R250	T538	T536	pobj	individuals,in
R251	T539	T514	punct	.,correlated
R252	T541	T542	prep	In,was
R253	T543	T544	compound	BC,individuals
R254	T544	T541	pobj	individuals,In
R255	T545	T546	det	the,correlation
R256	T546	T542	nsubj	correlation,was
R257	T547	T546	prep	with,correlation
R258	T548	T547	pobj	CEBPG,with
R259	T549	T550	advmod	significantly,lower
R260	T550	T542	acomp	lower,was
R262	T552	T549	parataxis	0.01,significantly
R263	T553	T552	nsubj	p,0.01
R264	T554	T552	punct	<,0.01
R266	T556	T550	prep	than,lower
R267	T557	T556	pobj	that,than
R268	T558	T557	prep	of,that
R269	T559	T560	amod	non-BC,individuals
R270	T560	T558	pobj	individuals,of
R271	T561	T542	prep	for,was
R272	T562	T561	pobj	four,for
R273	T563	T562	prep	of,four
R274	T564	T565	det	the,genes
R275	T565	T563	pobj	genes,of
R276	T566	T562	punct	(,four
R277	T567	T562	appos	XRCC1,four
R278	T568	T567	punct	", ",XRCC1
R279	T569	T567	conj	ERCC5,XRCC1
R280	T570	T569	punct	", ",ERCC5
R281	T571	T569	conj	GSTP1,ERCC5
R282	T572	T571	punct	", ",GSTP1
R283	T573	T571	cc	and,GSTP1
R284	T574	T571	conj	SOD1,GSTP1
R285	T575	T542	punct	),was
R286	T576	T542	cc	and,was
R287	T577	T578	det	the,difference
R288	T578	T579	nsubj	difference,was
R289	T579	T542	conj	was,was
R290	T580	T581	advmod	nearly,significant
R291	T581	T579	acomp	significant,was
R292	T582	T579	prep	for,was
R293	T583	T582	pobj	GPX1,for
R294	T584	T579	punct	.,was
R295	T586	T587	det	The,factor
R296	T587	T591	nsubj	factor,was
R300	T592	T587	acl	correlated,factor
R301	T593	T592	prep	with,correlated
R302	T594	T593	pobj	any,with
R303	T595	T594	prep	of,any
R304	T596	T597	det	these,genes
R305	T597	T595	pobj	genes,of
R308	T600	T592	prep	in,correlated
R309	T601	T602	amod	non-BC,individuals
R310	T602	T600	pobj	individuals,in
R311	T603	T591	attr	E2F1,was
R312	T604	T591	punct	.,was
R313	T606	T607	nsubjpass	E2F1,correlated
R314	T608	T607	auxpass	was,correlated
R315	T609	T607	prep	with,correlated
R316	T610	T609	pobj	GSTP1,with
R317	T611	T607	prep	among,correlated
R318	T612	T613	amod	non-BC,individuals
R319	T613	T611	pobj	individuals,among
R320	T614	T607	punct	", ",correlated
R321	T615	T607	cc	but,correlated
R322	T616	T617	prep	in,was
R323	T617	T607	conj	was,correlated
R329	T623	T624	det	no,difference
R330	T624	T617	attr	difference,was
R332	T626	T624	prep	in,difference
R333	T627	T628	det	this,correlation
R334	T628	T626	pobj	correlation,in
R335	T629	T624	prep	in,difference
R336	T630	T631	amod	non-BC,individuals
R337	T631	T629	pobj	individuals,in
R338	T632	T624	prep	compared,difference
R339	T633	T632	prep	to,compared
R340	T634	T635	compound	BC,individuals
R341	T635	T633	pobj	individuals,to
R342	T636	T617	punct	.,was
R343	T640	T641	nsubj	We,conclude
R344	T642	T643	mark	that,is
R345	T643	T641	ccomp	is,conclude
R347	T645	T646	det	the,factor
R348	T646	T643	attr	factor,is
R350	T648	T649	advmod	primarily,responsible
R351	T649	T646	amod	responsible,factor
R352	T650	T649	prep	for,responsible
R353	T651	T650	pcomp	regulating,for
R354	T652	T651	dobj	transcription,regulating
R355	T653	T652	prep	of,transcription
R356	T654	T655	amod	key,genes
R357	T655	T653	pobj	genes,of
R362	T660	T643	prep	in,is
R363	T661	T662	amod	non-BC,individuals
R364	T662	T660	pobj	individuals,in
R365	T663	T641	punct	.,conclude
R366	T665	T666	advmod	Further,conclude
R367	T667	T666	punct	", ",conclude
R368	T668	T666	nsubj	we,conclude
R369	T669	T670	mark	that,are
R370	T670	T666	ccomp	are,conclude
R372	T672	T670	nsubj	smokers,are
R373	T673	T672	amod	heavy,smokers
R379	T679	T670	attr	those,are
R380	T680	T681	dep	who,have
R381	T681	T679	relcl	have,those
R382	T682	T683	amod	sub-optimal,regulation
R383	T683	T681	dobj	regulation,have
R384	T684	T683	prep	of,regulation
R385	T685	T686	nmod	antioxidant,genes
R386	T686	T684	pobj	genes,of
R390	T690	T683	prep	by,regulation
R391	T691	T690	pobj	CEBPG,by
R392	T692	T666	punct	.,conclude
R393	T265	T266	compound	CEBPG,factor
R397	T927	T924	attr	cause,is
R398	T928	T927	amod	leading,cause
R401	T931	T933	amod	related,death
R402	T932	T931	punct	-,related
R406	T936	T934	pobj	States,in
R407	T937	T936	compound	United,States
R414	T944	T942	pobj	deaths,of
R415	T945	T944	compound	cancer,deaths
R421	T952	T955	advcl	is,develop
R422	T953	T954	compound	cigarette,smoking
R423	T954	T952	nsubj	smoking,is
R425	T957	T952	attr	factor,is
R426	T958	T957	amod	primary,factor
R427	T959	T957	compound	risk,factor
R430	T962	T965	nummod	15,%
R431	T963	T962	quantmod	10,15
R432	T964	T962	punct	–,15
R438	T970	T968	parataxis	years,smokers
R439	T971	T972	amod	greater,20
R441	T973	T972	quantmod	than,20
R442	T974	T970	compound	pack,years
R452	T985	T989	nsubjpass	enzymes,expressed
R453	T986	T984	cc	and,Antioxidant
R454	T987	T988	compound	DNA,repair
R455	T988	T984	conj	repair,Antioxidant
R468	T1002	T1000	pobj	cells,in
R469	T1003	T1002	compound	progenitor,cells
R474	T1008	T1002	appos	cells,cells
R475	T1009	T1008	amod	bronchial,cells
R476	T1010	T1008	amod	epithelial,cells
R485	T1020	T1022	nsubj	variation,plays
R486	T1021	T1020	amod	inter-individual,variation
R511	T1049	T1047	pobj	species,from
R512	T1050	T1049	compound	oxygen,species
R519	T1057	T1053	conj	xenobiotics,interaction
R520	T1058	T1056	prep	of,metabolism
R533	T1071	T1049	cc	as,species
R534	T1072	T1071	advmod	well,as
R539	T1077	T1075	pobj	metabolism,by
R540	T1078	T1077	amod	cellular,metabolism
R543	T1082	T1084	nsubj	species,cause
R544	T1083	T1082	compound	oxygen,species
R546	T1086	T1084	dobj	reactions,cause
R547	T1087	T1086	amod	damaging,reactions
R566	T1106	T1086	relcl	lead,reactions
R567	T1107	T1106	aux	can,lead
R578	T1120	T1118	dobj	damage,repair
R579	T1121	T1120	amod	frequent,damage
R587	T1129	T1127	cc	as,stress
R588	T1130	T1129	advmod	well,as
R608	T1152	T1149	ccomp	was,reported
R609	T1153	T1154	det	an,index
R610	T1154	T1152	nsubj	index,was
R611	T1155	T1154	amod	interactive,index
R612	T1156	T1157	compound	transcript,abundance
R613	T1157	T1154	compound	abundance,index
R614	T1158	T1154	acl	comprising,index
R615	T1159	T1160	compound	antioxidant,genes
R616	T1160	T1158	dobj	genes,comprising
R630	T1174	T1172	ccomp	selected,suggesting
R631	T1175	T1176	compound	BC,individuals
R632	T1176	T1174	nsubjpass	individuals,selected
R633	T1177	T1174	auxpass	are,selected
R639	T1183	T1181	pobj	protection,of
R640	T1184	T1183	compound	antioxidant,protection
R662	T1208	T1206	pobj	genes,of
R663	T1209	T1207	cc	or,antioxidant
R664	T1210	T1211	compound	DNA,repair
R665	T1211	T1207	conj	repair,antioxidant
R683	T1231	T1225	attr	GPX1,were
R684	T1232	T1231	punct	/,GPX1
R687	T1235	T1231	conj	GPX3,GPX1
R688	T1236	T1235	punct	/,GPX3
R692	T1240	T1235	conj	SOD1,GPX3
R693	T1241	T1240	punct	/,SOD1
R697	T1247	T1245	attr	characteristic,is
R698	T1248	T1247	amod	typical,characteristic
R705	T1257	T1255	attr	sites,is
R706	T1258	T1259	compound	transcription,factor
R707	T1259	T1260	compound	factor,recognition
R708	T1260	T1257	compound	recognition,sites
R711	T1263	T1261	pobj	regions,in
R712	T1264	T1263	amod	regulatory,regions
R723	T1277	T1275	pobj	findings,on
R724	T1278	T1277	amod	above,findings
R729	T1283	T1274	advcl	is,hypothesized
R730	T1284	T1283	punct	", ",is
R731	T1285	T1283	mark	that,is
R732	T1286	T1283	expl	there,is
R739	T1293	T1291	pobj	genes,of
R740	T1294	T1293	nmod	antioxidant,genes
R741	T1295	T1294	cc	and,antioxidant
R742	T1296	T1297	compound	DNA,repair
R743	T1297	T1294	conj	repair,antioxidant
R746	T1300	T1298	pobj	factors,by
R747	T1301	T1299	cc	or,one
R748	T1302	T1299	conj	more,one
R749	T1303	T1300	compound	transcription,factors
R752	T1306	T1283	conj	selected,is
R753	T1307	T1306	punct	", ",selected
R754	T1308	T1306	mark	that,selected
R755	T1309	T1306	nsubjpass	individuals,selected
R756	T1310	T1309	prep	with,individuals
R757	T1311	T1312	amod	sub-optimal,regulation
R758	T1312	T1310	pobj	regulation,with
R759	T1313	T1306	auxpass	are,selected
R765	T1319	T1306	advcl	smoke,selected
R766	T1320	T1319	nsubj	they,smoke
R776	T1332	T1326	nsubjpass	sites,identified
R777	T1333	T1332	compound	recognition,sites
R781	T1337	T1335	pobj	regions,to
R782	T1338	T1337	amod	regulatory,regions
R785	T1341	T1339	pobj	pairs,of
R786	T1342	T1343	amod	above,correlated
R787	T1343	T1341	amod	correlated,pairs
R788	T1344	T1341	compound	gene,pairs
R793	T1349	T1346	pobj	analysis,through
R794	T1350	T1351	compound	DNA,sequence
R795	T1351	T1349	compound	sequence,analysis
R799	T1355	T1357	nsubj	abundance,measured
R800	T1356	T1355	compound	transcript,abundance
R805	T1361	T1359	pobj	group,with
R806	T1362	T1361	amod	expanded,group
R810	T1366	T1363	pobj	genes,of
R811	T1367	T1365	cc	and,antioxidant
R812	T1368	T1369	nummod	six,repair
R814	T1370	T1369	compound	DNA,repair
R819	T1395	T1397	nsubjpass	samples,obtained
R820	T1396	T1395	compound	biopsy,samples
R823	T1400	T1398	pobj	epithelium,of
R824	T1401	T1400	amod	bronchial,epithelium
R841	T1418	T1397	parataxis	11,obtained
R842	T1419	T1418	nummod	9,11
R843	T1420	T1418	punct	",",11
R847	T1425	T1427	nsubjpass	epithelium,brushed
R848	T1426	T1425	amod	bronchial,epithelium
R862	T1441	T1439	pobj	area,of
R863	T1442	T1441	amod	suspected,area
R864	T1443	T1441	amod	cancerous,area
R876	T1457	T1455	pobj	Board,of
R877	T1458	T1457	compound	Institutional,Board
R878	T1459	T1457	compound	Review,Board
R881	T1462	T1460	pobj	University,for
R882	T1463	T1462	compound	Medical,University
R887	T1469	T1471	nsubjpass	diagnosis,determined
R888	T1470	T1469	compound	BC,diagnosis
R903	T1486	T1484	pobj	University,at
R904	T1487	T1486	compound	Medical,University
R919	T1504	T1502	pobj	individuals,including
R920	T1505	T1504	amod	non-BC,individuals
R923	T1508	T1504	conj	individuals,individuals
R924	T1509	T1508	compound	BC,individuals
R932	T1518	T1520	nsubjpass	characteristics,presented
R933	T1519	T1518	amod	biographical,characteristics
R945	T1610	T1612	nsubjpass	samples,transcribed
R946	T1611	T1610	compound	RNA,samples
R954	T1620	T1622	nmod	MLV,transcriptase
R955	T1621	T1620	punct	-,MLV
R956	T1622	T1618	dobj	transcriptase,using
R957	T1623	T1622	amod	reverse,transcriptase
R963	T1629	T1612	advcl	described,transcribed
R964	T1630	T1629	advmod	previously,described
R966	T1632	T1612	parataxis	11,transcribed
R967	T1633	T1632	nummod	9,11
R968	T1634	T1632	punct	",",11
R973	T1640	T1645	nsubjpass	PCR,used
R974	T1641	T1639	punct	(,RT
R975	T1642	T1639	appos	StaRT,RT
R976	T1643	T1640	punct	),PCR
R977	T1644	T1640	punct	-,PCR
R989	T1659	T1656	pobj	PCR,With
R990	T1660	T1659	punct	-,PCR
R993	T1663	T1657	nsubjpass	standard,included
R994	T1664	T1663	amod	internal,standard
R1000	T1670	T1668	pobj	mixture,within
R1001	T1671	T1670	amod	standardized,mixture
R1011	T1681	T1679	pobj	reaction,in
R1012	T1682	T1681	compound	PCR,reaction
R1021	T1693	T1691	pobj	Bioanalyzer,on
R1022	T1694	T1693	nmod	Agilent,Bioanalyzer
R1023	T1695	T1694	nummod	2100,Agilent
R1029	T1701	T1703	compound	Kit,reagents
R1030	T1702	T1701	nummod	1000,Kit
R1038	T1710	T1707	pobj	protocol,to
R1039	T1711	T1709	case	's,manufacturer
R1041	T1713	T1696	parataxis	GmbH,using
R1042	T1714	T1715	compound	Agilent,Technologies
R1043	T1715	T1713	compound	Technologies,GmbH
R1044	T1716	T1713	compound	Deutschland,GmbH
R1052	T1725	T1729	nsubjpass	technology,licensed
R1053	T1726	T1727	compound	StaRT,PCR
R1055	T1728	T1727	punct	-,PCR
R1087	T1764	T1766	compound	PCR,reagents
R1088	T1765	T1764	punct	-,PCR
R1094	T1772	T1770	pobj	genes,of
R1095	T1773	T1772	amod	measured,genes
R1114	T1792	T1767	parataxis	12,prepared
R1115	T1793	T1792	nummod	11,12
R1116	T1794	T1792	punct	",",12
R1131	T1813	T1810	dobj	standard,Including
R1132	T1814	T1813	amod	internal,standard
R1141	T1823	T1821	pobj	sources,for
R1142	T1824	T1823	amod	known,sources
R1156	T1838	T1840	amod	multiplexed,data
R1157	T1839	T1838	punct	-,multiplexed
R1158	T1840	T1836	dobj	data,generates
R1159	T1841	T1842	compound	transcript,abundance
R1160	T1842	T1840	compound	abundance,data
R1175	T1858	T1860	nsubj	characteristics,are
R1176	T1859	T1858	compound	performance,characteristics
R1179	T1863	T1861	pobj	PCR,of
R1180	T1864	T1863	punct	-,PCR
R1188	T1872	T1869	pobj	technology,of
R1189	T1873	T1874	amod	quantitative,PCR
R1190	T1874	T1872	compound	PCR,technology
R1206	T1892	T1885	nsubj	property,is
R1207	T1893	T1892	amod	key,property
R1210	T1896	T1894	pobj	method,of
R1211	T1897	T1898	amod	quantitative,PCR
R1212	T1898	T1896	compound	PCR,method
R1215	T1901	T1885	attr	measured,is
R1216	T1902	T1903	det	the,products
R1218	T1904	T1903	compound	PCR,products
R1219	T1905	T1901	auxpass	are,measured
R1221	T1907	T1901	prep	at,measured
R1222	T1908	T1907	cc	or,at
R1228	T1914	T1901	conj	are,measured
R1229	T1915	T1914	expl	there,are
R1239	T1926	T1929	nsubjpass	characteristics,presented
R1240	T1927	T1926	amod	overall,characteristics
R1241	T1928	T1926	compound	performance,characteristics
R1244	T1932	T1930	pobj	PCR,of
R1245	T1933	T1932	punct	-,PCR
R1260	T1948	T1946	pobj	articles,in
R1261	T1949	T1948	amod	recent,articles
R1284	T1974	T1960	nsubj	reagents,had
R1285	T1975	T1976	compound	StaRT,PCR
R1287	T1977	T1976	punct	-,PCR
R1289	T1979	T1960	dobj	threshold,had
R1290	T1980	T1979	compound	detection,threshold
R1293	T1983	T1985	nummod	10,molecules
R1294	T1984	T1983	quantmod	than,10
R1298	T1988	T1979	conj	range,threshold
R1299	T1989	T1988	amod	dynamic,range
R1302	T1992	T1994	nummod	six,orders
R1303	T1993	T1992	quantmod	than,six
R1308	T1998	T1994	parataxis	10,orders
R1309	T1999	T1998	amod	less,10
R1310	T2000	T1998	quantmod	than,10
R1319	T2009	T1988	conj	response,range
R1320	T2010	T2008	punct	-,signal
R1321	T2011	T2008	prep	to,signal
R1322	T2012	T2011	punct	-,to
R1323	T2013	T2011	pobj	analyte,to
R1335	T2027	T2025	pobj	standard,of
R1336	T2028	T2027	amod	internal,standard
R1347	T2039	T2036	relcl	are,inhibitors
R1348	T2040	T2039	advmod	often,are
R1350	T2042	T2039	acomp	specific,are
R1351	T2043	T2042	punct	-,specific
R1356	T2048	T2046	dobj	negatives,ensures
R1357	T2049	T2048	amod	false,negatives
R1359	T2051	T2046	parataxis	observed,ensures
R1360	T2052	T2053	mark	if,fails
R1361	T2053	T2051	advcl	fails,observed
R1362	T2054	T2055	det	the,PCR
R1363	T2055	T2053	nsubj	PCR,fails
R1364	T2056	T2057	det	the,product
R1365	T2057	T2051	nsubjpass	product,observed
R1366	T2058	T2057	amod	internal,product
R1367	T2059	T2057	amod	standard,product
R1368	T2060	T2057	compound	PCR,product
R1369	T2061	T2051	auxpass	is,observed
R1370	T2062	T2051	neg	not,observed
R1387	T2081	T2079	pobj	reaction,of
R1388	T2082	T2081	compound	control,reaction
R1389	T2083	T2081	compound	PCR,reaction
R1398	T2166	T2168	nummod	"6,000",measurements
R1399	T2167	T2166	quantmod	than,"6,000"
R1400	T2168	T2171	nsubjpass	measurements,conducted
R1401	T2169	T2170	compound	transcript,abundance
R1402	T2170	T2168	compound	abundance,measurements
R1413	T2182	T2180	dobj	factors,assess
R1414	T2183	T2182	nummod	six,factors
R1415	T2184	T2182	compound	transcription,factors
R1418	T2187	T2182	conj	genes,factors
R1419	T2188	T2187	nmod	antioxidant,genes
R1420	T2189	T2188	cc	and,antioxidant
R1421	T2190	T2191	compound	DNA,repair
R1422	T2191	T2188	conj	repair,antioxidant
R1430	T2199	T2197	parataxis	individuals,individuals
R1431	T2200	T2199	nummod	24,individuals
R1432	T2201	T2199	amod	non-BC,individuals
R1435	T2204	T2199	conj	individuals,individuals
R1436	T2205	T2204	compound	BC,individuals
R1444	T2215	T2213	pobj	factors,of
R1445	T2216	T2215	nummod	six,factors
R1446	T2217	T2215	compound	transcription,factors
R1451	T2222	T2220	pobj	genes,of
R1452	T2223	T2222	nmod	antioxidant,genes
R1453	T2224	T2223	cc	or,antioxidant
R1454	T2225	T2226	compound	DNA,repair
R1455	T2226	T2223	conj	repair,antioxidant
R1459	T2230	T2228	pobj	correlation,by
R1460	T2231	T2229	case	's,Pearson
R1471	T2244	T2241	pobj	variation,due
R1472	T2245	T2244	amod	wide,variation
R1473	T2246	T2244	amod	biological,variation
R1503	T2278	T2276	pobj	factors,of
R1504	T2279	T2278	compound	transcription,factors
R1509	T2284	T2282	pobj	genes,of
R1510	T2285	T2284	nmod	antioxidant,genes
R1511	T2286	T2285	cc	or,antioxidant
R1512	T2287	T2288	compound	DNA,repair
R1513	T2288	T2285	conj	repair,antioxidant
R1527	T2304	T2302	pobj	test,by
R1528	T2305	T2303	case	's,Fisher
R1529	T2306	T2307	compound	Z,transformation
R1531	T2308	T2307	punct	-,transformation
R1542	T2321	T2323	amod	multiplexed,data
R1543	T2322	T2321	punct	-,multiplexed
R1544	T2323	T2319	pobj	data,between
R1545	T2324	T2325	compound	transcript,abundance
R1546	T2325	T2323	compound	abundance,data
R1555	T2334	T2332	pobj	correlation,by
R1556	T2335	T2333	case	's,Pearson
R1562	T2341	T2339	pobj	test,by
R1563	T2342	T2341	punct	-,test
R1574	T2353	T2351	pobj	test,by
R1575	T2354	T2352	case	's,Duncan
R1579	T2482	T2483	compound	Transcription,factor
R1580	T2483	T2484	compound	factor,site
R1581	T2484	T2486	compound	site,analysis
R1582	T2485	T2484	compound	recognition,site
R1583	T2488	T2489	det	The,program
R1584	T2489	T2496	nsubjpass	program,used
R1585	T2490	T2491	nmod	El,Dorado
R1586	T2491	T2489	nmod	Dorado,program
R1587	T2492	T2493	punct	(,Build
R1588	T2493	T2491	parataxis	Build,Dorado
R1589	T2494	T2493	nummod	35,Build
R1590	T2495	T2493	punct	),Build
R1591	T2497	T2489	prep	from,program
R1592	T2498	T2499	det	the,package
R1594	T2500	T2499	compound	Genomatix,package
R1595	T2501	T2499	compound	software,package
R1596	T2502	T2496	auxpass	was,used
R1597	T2503	T2504	aux	to,locate
R1598	T2504	T2496	advcl	locate,used
R1599	T2505	T2506	det	the,genes
R1600	T2506	T2504	dobj	genes,locate
R1601	T2507	T2506	amod	correlated,genes
R1602	T2508	T2504	prep	within,locate
R1603	T2509	T2510	det	the,genome
R1604	T2510	T2508	pobj	genome,within
R1605	T2511	T2504	cc	and,locate
R1606	T2512	T2504	conj	define,locate
R1607	T2513	T2514	nummod	1101,pairs
R1608	T2514	T2512	dobj	pairs,define
R1609	T2515	T2514	compound	base,pairs
R1610	T2516	T2514	prep	of,pairs
R1611	T2517	T2518	det	the,regions
R1612	T2518	T2516	pobj	regions,of
R1613	T2519	T2518	compound	promoter,regions
R1614	T2520	T2521	punct	(,pairs
R1616	T2522	T2521	nummod	1000,pairs
R1617	T2523	T2521	compound	base,pairs
R1618	T2524	T2521	advmod	upstream,pairs
R1619	T2525	T2524	prep	of,upstream
R1620	T2526	T2521	cc	and,pairs
R1621	T2527	T2528	nummod	100,pairs
R1622	T2528	T2530	nmod	pairs,site
R1623	T2529	T2528	nmod	base,pairs
R1624	T2530	T2521	conj	site,pairs
R1625	T2531	T2528	prep	into,pairs
R1626	T2532	T2530	det	the,site
R1627	T2533	T2530	compound	transcription,site
R1628	T2534	T2530	compound	start,site
R1629	T2535	T2521	punct	),pairs
R1630	T2536	T2512	prep	for,define
R1631	T2537	T2538	det	each,gene
R1632	T2538	T2536	pobj	gene,for
R1633	T2539	T2540	punct	(,GmbH
R1635	T2541	T2540	compound	Genomatix,GmbH
R1636	T2542	T2540	compound	Software,GmbH
R1637	T2543	T2540	punct	", ",GmbH
R1638	T2544	T2540	npadvmod	Munich,GmbH
R1639	T2545	T2540	punct	", ",GmbH
R1640	T2546	T2540	npadvmod	Germany,GmbH
R1641	T2547	T2540	punct	", ",GmbH
R1642	T2548	T2549	punct	[,17
R1643	T2549	T2540	parataxis	17,GmbH
R1644	T2550	T2549	punct	],17
R1645	T2551	T2540	punct	),GmbH
R1646	T2552	T2496	punct	.,used
R1647	T2554	T2555	det	The,sequences
R1648	T2555	T2559	nsubjpass	sequences,used
R1649	T2556	T2557	nummod	1101,pair
R1650	T2557	T2555	compound	pair,sequences
R1651	T2558	T2557	compound	base,pair
R1652	T2560	T2555	acl	obtained,sequences
R1653	T2561	T2560	prep	from,obtained
R1654	T2562	T2563	det	the,program
R1656	T2564	T2565	compound	El,Dorado
R1657	T2565	T2563	compound	Dorado,program
R1658	T2566	T2559	advmod	then,used
R1659	T2567	T2559	auxpass	were,used
R1660	T2568	T2559	prep	as,used
R1661	T2569	T2570	det	the,sequences
R1662	T2570	T2568	pobj	sequences,as
R1663	T2571	T2570	compound	target,sequences
R1664	T2572	T2570	prep	for,sequences
R1665	T2573	T2574	amod	putative,identification
R1666	T2574	T2572	pobj	identification,for
R1667	T2575	T2576	compound	transcription,factor
R1668	T2576	T2577	compound	factor,site
R1669	T2577	T2574	compound	site,identification
R1670	T2578	T2577	compound	recognition,site
R1671	T2579	T2559	advcl	using,used
R1672	T2580	T2581	det	the,program
R1673	T2581	T2579	dobj	program,using
R1674	T2582	T2581	nmod	MatInspector,program
R1675	T2583	T2581	nmod	Version,program
R1676	T2584	T2583	nummod	4.2,Version
R1677	T2585	T2581	punct	", ",program
R1678	T2586	T2587	dep	which,yielded
R1679	T2587	T2581	relcl	yielded,program
R1680	T2588	T2587	dobj	sites,yielded
R1681	T2589	T2588	prep	for,sites
R1682	T2590	T2591	nummod	11,factors
R1683	T2591	T2589	pobj	factors,for
R1684	T2592	T2591	compound	transcription,factors
R1685	T2593	T2594	punct	(,GmbH
R1687	T2595	T2594	compound	Genomatix,GmbH
R1688	T2596	T2594	compound	Software,GmbH
R1689	T2597	T2594	punct	", ",GmbH
R1690	T2598	T2594	npadvmod	Munich,GmbH
R1691	T2599	T2594	punct	", ",GmbH
R1692	T2600	T2594	npadvmod	Germany,GmbH
R1693	T2601	T2594	punct	", ",GmbH
R1694	T2602	T2603	punct	[,17
R1695	T2603	T2594	parataxis	17,GmbH
R1696	T2604	T2603	punct	],17
R1697	T2605	T2594	punct	),GmbH
R1698	T2606	T2559	punct	.,used
R1699	T2608	T2609	det	The,parameters
R1700	T2609	T2610	nsubj	parameters,were
R1701	T2611	T2609	acl	used,parameters
R1702	T2612	T2613	det	the,similarity
R1703	T2613	T2610	attr	similarity,were
R1704	T2614	T2613	nmod	standard,similarity
R1705	T2615	T2616	punct	(,0.75
R1706	T2616	T2614	parataxis	0.75,standard
R1707	T2617	T2616	punct	),0.75
R1708	T2618	T2613	compound	core,similarity
R1709	T2619	T2613	cc	and,similarity
R1710	T2620	T2621	det	the,similarity
R1712	T2622	T2621	amod	optimized,similarity
R1713	T2623	T2621	compound	matrix,similarity
R1714	T2624	T2625	punct	[,18
R1715	T2625	T2610	parataxis	18,were
R1716	T2626	T2625	punct	],18
R1717	T2627	T2610	punct	.,were
R1718	T2629	T2630	compound	StaRT,PCR
R1719	T2630	T2632	compound	PCR,reagents
R1720	T2631	T2630	punct	-,PCR
R1721	T2632	T2633	nsubjpass	reagents,optimized
R1722	T2634	T2633	auxpass	were,optimized
R1723	T2635	T2633	prep	for,optimized
R1724	T2636	T2635	pobj	ten,for
R1725	T2637	T2636	prep	of,ten
R1726	T2638	T2639	det	these,factors
R1727	T2639	T2637	pobj	factors,of
R1728	T2640	T2639	compound	transcription,factors
R1729	T2641	T2636	punct	", ",ten
R1730	T2642	T2636	prep	including,ten
R1731	T2643	T2642	pobj	CEBPB,including
R1732	T2644	T2643	punct	", ",CEBPB
R1733	T2645	T2643	conj	CEBPE,CEBPB
R1734	T2646	T2645	punct	", ",CEBPE
R1735	T2647	T2645	conj	CEBPG,CEBPE
R1736	T2648	T2647	punct	", ",CEBPG
R1737	T2649	T2647	conj	E2F1,CEBPG
R1738	T2650	T2649	punct	", ",E2F1
R1739	T2651	T2649	conj	E2F3,E2F1
R1740	T2652	T2651	punct	", ",E2F3
R1741	T2653	T2651	conj	E2F4,E2F3
R1742	T2654	T2653	punct	", ",E2F4
R1743	T2655	T2653	conj	E2F5,E2F4
R1744	T2656	T2655	punct	", ",E2F5
R1745	T2657	T2655	conj	E2F6,E2F5
R1746	T2658	T2657	punct	", ",E2F6
R1747	T2659	T2657	conj	EVI1,E2F6
R1748	T2660	T2659	punct	", ",EVI1
R1749	T2661	T2659	cc	and,EVI1
R1750	T2662	T2659	conj	PAX5,EVI1
R1751	T2663	T2633	punct	.,optimized
R1752	T2665	T2666	nummod	Four,factors
R1753	T2666	T2668	nsubjpass	factors,expressed
R1754	T2667	T2666	compound	transcription,factors
R1755	T2669	T2668	auxpass	were,expressed
R1756	T2670	T2668	prep	at,expressed
R1757	T2671	T2672	amod	low,levels
R1759	T2673	T2671	cc	and,low
R1760	T2674	T2671	conj	invariant,low
R1761	T2675	T2668	prep	among,expressed
R1762	T2676	T2677	amod	multiple,samples
R1763	T2677	T2675	pobj	samples,among
R1764	T2678	T2677	compound	NBEC,samples
R1765	T2679	T2668	cc	and,expressed
R1766	T2680	T2681	auxpass	were,excluded
R1767	T2681	T2668	conj	excluded,expressed
R1768	T2682	T2681	advmod	therefore,excluded
R1769	T2683	T2681	prep	from,excluded
R1770	T2684	T2685	det	the,study
R1771	T2685	T2683	pobj	study,from
R1772	T2686	T2668	punct	.,expressed
R1773	T2688	T2689	det	The,six
R1774	T2689	T2691	nsubjpass	six,evaluated
R1775	T2690	T2689	amod	remaining,six
R1776	T2692	T2689	punct	", ",six
R1777	T2693	T2689	appos	CEBPB,six
R1778	T2694	T2693	punct	", ",CEBPB
R1779	T2695	T2693	conj	CEBPG,CEBPB
R1780	T2696	T2695	punct	", ",CEBPG
R1781	T2697	T2695	conj	E2F1,CEBPG
R1782	T2698	T2697	punct	", ",E2F1
R1783	T2699	T2697	conj	E2F3,E2F1
R1784	T2700	T2699	punct	", ",E2F3
R1785	T2701	T2699	conj	E2F6,E2F3
R1786	T2702	T2701	punct	", ",E2F6
R1787	T2703	T2701	cc	and,E2F6
R1788	T2704	T2701	conj	EVI,E2F6
R1789	T2705	T2691	punct	", ",evaluated
R1790	T2706	T2691	auxpass	were,evaluated
R1791	T2707	T2691	prep	for,evaluated
R1792	T2708	T2707	pobj	correlation,for
R1793	T2709	T2708	prep	with,correlation
R1794	T2710	T2711	det	an,group
R1795	T2711	T2709	pobj	group,with
R1796	T2712	T2711	amod	expanded,group
R1797	T2713	T2711	prep	of,group
R1798	T2714	T2715	nummod	ten,antioxidant
R1799	T2715	T2713	pobj	antioxidant,of
R1800	T2716	T2715	cc	and,antioxidant
R1801	T2717	T2718	nummod	six,repair
R1802	T2718	T2720	compound	repair,genes
R1803	T2719	T2718	compound	DNA,repair
R1804	T2720	T2715	conj	genes,antioxidant
R1805	T2721	T2691	punct	.,evaluated
R1806	T2747	T2748	advmod	virtually,multiplexed
R1807	T2748	T2750	amod	multiplexed,data
R1808	T2749	T2748	punct	-,multiplexed
R1810	T2751	T2752	compound	transcript,abundance
R1811	T2752	T2750	compound	abundance,data
R1812	T2754	T2753	auxpass	were,obtained
R1813	T2755	T2753	prep	for,obtained
R1814	T2756	T2757	det	each,gene
R1815	T2757	T2755	pobj	gene,for
R1816	T2758	T2753	prep	in,obtained
R1817	T2759	T2758	pobj	each,in
R1818	T2760	T2759	prep	of,each
R1819	T2761	T2762	det	the,samples
R1820	T2762	T2760	pobj	samples,of
R1821	T2763	T2762	nummod	49,samples
R1822	T2764	T2753	punct	", ",obtained
R1823	T2765	T2753	prep	except,obtained
R1824	T2766	T2765	prep	for,except
R1825	T2767	T2768	compound	E2F1,measurement
R1826	T2768	T2766	pobj	measurement,for
R1827	T2769	T2768	prep	in,measurement
R1828	T2770	T2769	pobj	sample,in
R1829	T2771	T2770	nummod	147,sample
R1830	T2772	T2773	punct	(,Table
R1831	T2773	T2753	parataxis	Table,obtained
R1832	T2774	T2773	nummod	3,Table
R1833	T2775	T2773	punct	),Table
R1834	T2776	T2753	punct	.,obtained
R1835	T2778	T2779	det	A,inhibitor
R1836	T2779	T2783	nsubj	inhibitor,prevented
R1837	T2780	T2781	npadvmod	gene,specific
R1838	T2781	T2779	amod	specific,inhibitor
R1839	T2782	T2781	punct	-,specific
R1840	T2784	T2779	prep	in,inhibitor
R1841	T2785	T2784	pobj	sample,in
R1842	T2786	T2785	nummod	147,sample
R1843	T2787	T2783	dobj	amplification,prevented
R1844	T2788	T2787	prep	of,amplification
R1845	T2789	T2788	pobj	E2F1,of
R1846	T2790	T2783	punct	.,prevented
R1847	T2792	T2793	preconj	Neither,standard
R1849	T2794	T2793	det	the,standard
R1850	T2795	T2793	amod	internal,standard
R1851	T2797	T2793	punct	", ",standard
R1852	T2798	T2793	cc	nor,standard
R1853	T2799	T2800	det	the,product
R1854	T2800	T2793	conj	product,standard
R1855	T2801	T2800	amod	native,product
R1856	T2802	T2800	compound	cDNA,product
R1857	T2803	T2800	compound	PCR,product
R1858	T2804	T2796	auxpass	was,observed
R1859	T2805	T2796	punct	.,observed
R1860	T2807	T2808	det	The,presence
R1861	T2808	T2809	nsubj	presence,was
R1862	T2810	T2808	prep	of,presence
R1863	T2811	T2812	npadvmod	gene,specific
R1864	T2812	T2814	amod	specific,inhibition
R1865	T2813	T2812	punct	-,specific
R1866	T2814	T2810	pobj	inhibition,of
R1867	T2815	T2814	compound	PCR,inhibition
R1868	T2816	T2809	acomp	observable,was
R1869	T2817	T2809	prep	in,was
R1870	T2818	T2819	det	some,samples
R1871	T2819	T2817	pobj	samples,in
R1872	T2820	T2819	amod	other,samples
R1873	T2821	T2809	prep	as,was
R1874	T2822	T2821	pobj	reduction,as
R1875	T2823	T2822	prep	in,reduction
R1876	T2824	T2825	compound	peak,heights
R1877	T2825	T2823	pobj	heights,in
R1878	T2826	T2822	prep	in,reduction
R1879	T2827	T2828	amod	internal,products
R1881	T2829	T2828	amod	standard,products
R1882	T2830	T2828	compound	PCR,products
R1883	T2831	T2822	amod	relative,reduction
R1884	T2832	T2831	prep	to,relative
R1885	T2833	T2832	pobj	that,to
R1886	T2834	T2833	acl	expected,that
R1887	T2835	T2834	prep	for,expected
R1888	T2836	T2837	det	the,number
R1889	T2837	T2835	pobj	number,for
R1890	T2838	T2837	prep	of,number
R1891	T2839	T2840	amod	internal,molecules
R1892	T2840	T2838	pobj	molecules,of
R1893	T2841	T2840	amod	standard,molecules
R1894	T2842	T2840	amod	present,molecules
R1895	T2843	T2842	prep	at,present
R1896	T2844	T2845	det	the,beginning
R1897	T2845	T2843	pobj	beginning,at
R1898	T2846	T2845	prep	of,beginning
R1899	T2847	T2848	det	the,reaction
R1900	T2848	T2846	pobj	reaction,of
R1901	T2849	T2848	compound	PCR,reaction
R1902	T2850	T2809	punct	.,was
R1903	T2852	T2853	advmod	However,was
R1904	T2854	T2853	punct	", ",was
R1905	T2855	T2853	prep	in,was
R1906	T2856	T2857	det	each,case
R1907	T2857	T2855	pobj	case,in
R1908	T2858	T2857	amod	such,case
R1909	T2859	T2853	punct	", ",was
R1910	T2860	T2861	det	the,amplification
R1911	T2861	T2853	nsubj	amplification,was
R1912	T2862	T2861	compound	PCR,amplification
R1913	T2863	T2853	acomp	efficient,was
R1914	T2864	T2863	advmod	enough,efficient
R1915	T2865	T2866	aux	to,enable
R1916	T2866	T2863	xcomp	enable,efficient
R1917	T2867	T2866	dobj	quantification,enable
R1918	T2868	T2853	punct	.,was
R1919	T3076	T3077	compound	Bivariate,analysis
R1920	T3079	T3080	prep	In,was
R1921	T3081	T3082	amod	non-BC,individuals
R1922	T3082	T3079	pobj	individuals,In
R1923	T3083	T3080	expl	there,was
R1924	T3084	T3085	amod	significant,correlation
R1925	T3085	T3080	attr	correlation,was
R1926	T3086	T3087	punct	(,0.01
R1927	T3087	T3084	parataxis	0.01,significant
R1928	T3088	T3087	nsubj	p,0.01
R1929	T3089	T3087	punct	<,0.01
R1930	T3090	T3087	punct	),0.01
R1931	T3091	T3085	prep	between,correlation
R1932	T3092	T3091	pobj	CEBPG,between
R1933	T3093	T3092	cc	and,CEBPG
R1934	T3094	T3095	quantmod	eight,16
R1936	T3096	T3095	quantmod	of,16
R1937	T3097	T3095	quantmod	the,16
R1938	T3098	T3092	conj	genes,CEBPG
R1939	T3099	T3098	nmod	antioxidant,genes
R1940	T3100	T3099	cc	or,antioxidant
R1941	T3101	T3102	compound	DNA,repair
R1942	T3102	T3099	conj	repair,antioxidant
R1943	T3103	T3098	punct	", ",genes
R1944	T3104	T3105	advmod	specifically,XRCC1
R1945	T3105	T3098	appos	XRCC1,genes
R1946	T3106	T3105	punct	", ",XRCC1
R1947	T3107	T3105	conj	ERCC5,XRCC1
R1948	T3108	T3107	punct	", ",ERCC5
R1949	T3109	T3107	conj	GSTP1,ERCC5
R1950	T3110	T3109	punct	", ",GSTP1
R1951	T3111	T3109	conj	SOD1,GSTP1
R1952	T3112	T3111	punct	", ",SOD1
R1953	T3113	T3111	conj	GPX1,SOD1
R1954	T3114	T3113	punct	", ",GPX1
R1955	T3115	T3113	conj	ERCC1,GPX1
R1956	T3116	T3115	punct	", ",ERCC1
R1957	T3117	T3115	conj	CAT,ERCC1
R1958	T3118	T3117	cc	and,CAT
R1959	T3119	T3117	conj	ERCC2,CAT
R1960	T3120	T3121	punct	(,Table
R1961	T3121	T3080	parataxis	Table,was
R1962	T3122	T3121	nummod	4,Table
R1963	T3123	T3121	punct	),Table
R1964	T3124	T3080	punct	.,was
R1965	T3126	T3127	prep	In,correlated
R1966	T3128	T3126	pobj	contrast,In
R1967	T3129	T3127	punct	", ",correlated
R1968	T3130	T3127	prep	in,correlated
R1969	T3131	T3132	compound	BC,individuals
R1970	T3132	T3130	pobj	individuals,in
R1971	T3133	T3134	compound	samples,CEBPG
R1972	T3134	T3127	nsubjpass	CEBPG,correlated
R1973	T3135	T3127	auxpass	was,correlated
R1974	T3136	T3127	neg	not,correlated
R1975	T3137	T3127	prep	with,correlated
R1976	T3138	T3137	pobj	any,with
R1977	T3139	T3138	prep	of,any
R1978	T3140	T3141	det	the,genes
R1979	T3141	T3139	pobj	genes,of
R1980	T3142	T3141	nmod	antioxidant,genes
R1981	T3143	T3142	cc	or,antioxidant
R1982	T3144	T3145	compound	DNA,repair
R1983	T3145	T3142	conj	repair,antioxidant
R1984	T3146	T3127	punct	.,correlated
R1985	T3148	T3149	det	These,relationships
R1986	T3149	T3150	nsubjpass	relationships,observed
R1987	T3151	T3150	auxpass	were,observed
R1988	T3152	T3150	neg	not,observed
R1989	T3153	T3150	prep	with,observed
R1990	T3154	T3153	pobj	any,with
R1991	T3155	T3154	prep	of,any
R1992	T3156	T3157	det	the,factors
R1994	T3158	T3157	amod	other,factors
R1995	T3159	T3157	compound	transcription,factors
R1996	T3160	T3157	acl	studied,factors
R1997	T3161	T3150	punct	.,observed
R1998	T3163	T3164	prep	For,was
R1999	T3165	T3163	pobj	XRCC1,For
R2000	T3166	T3165	punct	", ",XRCC1
R2001	T3167	T3165	conj	ERCC5,XRCC1
R2002	T3168	T3167	punct	", ",ERCC5
R2003	T3169	T3167	conj	GSTP1,ERCC5
R2004	T3170	T3169	punct	", ",GSTP1
R2005	T3171	T3169	cc	and,GSTP1
R2006	T3172	T3169	conj	SOD1,GSTP1
R2007	T3173	T3174	det	the,correlation
R2008	T3174	T3164	nsubj	correlation,was
R2009	T3175	T3174	prep	with,correlation
R2010	T3176	T3175	pobj	CEBPG,with
R2011	T3177	T3178	advmod	significantly,lower
R2012	T3178	T3164	acomp	lower,was
R2013	T3179	T3164	prep	in,was
R2014	T3180	T3181	compound	BC,individuals
R2015	T3181	T3179	pobj	individuals,in
R2016	T3182	T3164	prep	compared,was
R2017	T3183	T3182	prep	to,compared
R2018	T3184	T3185	amod	non-BC,individuals
R2019	T3185	T3183	pobj	individuals,to
R2020	T3186	T3164	cc	and,was
R2021	T3187	T3188	det	the,difference
R2022	T3188	T3189	nsubj	difference,was
R2023	T3189	T3164	conj	was,was
R2024	T3190	T3191	advmod	nearly,significant
R2025	T3191	T3189	acomp	significant,was
R2026	T3192	T3189	prep	for,was
R2027	T3193	T3192	pobj	GPX1,for
R2028	T3194	T3195	punct	(,Fig.
R2029	T3195	T3189	parataxis	Fig.,was
R2030	T3196	T3195	nummod	1b,Fig.
R2031	T3197	T3195	punct	),Fig.
R2032	T3198	T3164	punct	.,was
R2033	T3200	T3201	compound	Scatter,plots
R2034	T3201	T3202	nsubj	plots,are
R2035	T3203	T3201	prep	of,plots
R2036	T3204	T3205	det	the,relationship
R2037	T3205	T3203	pobj	relationship,of
R2038	T3206	T3205	prep	between,relationship
R2039	T3207	T3206	pobj	CEBPG,between
R2040	T3208	T3207	cc	and,CEBPG
R2041	T3209	T3207	conj	XRCC1,CEBPG
R2042	T3210	T3205	prep	in,relationship
R2043	T3211	T3212	amod	non-BC,individuals
R2044	T3212	T3210	pobj	individuals,in
R2045	T3213	T3212	cc	or,individuals
R2046	T3214	T3215	compound	BC,individuals
R2047	T3215	T3212	conj	individuals,individuals
R2048	T3216	T3217	punct	(,b
R2049	T3217	T3201	parataxis	b,plots
R2050	T3218	T3217	nmod	Fig.,b
R2051	T3219	T3217	nummod	2a,b
R2052	T3220	T3217	punct	",",b
R2053	T3221	T3217	punct	),b
R2054	T3222	T3202	acomp	representative,are
R2055	T3223	T3222	prep	of,representative
R2056	T3224	T3225	det	the,genes
R2058	T3226	T3225	amod	other,genes
R2059	T3227	T3225	nummod	four,genes
R2060	T3228	T3202	punct	.,are
R2061	T3230	T3231	preconj	Neither,CEBPG
R2062	T3231	T3232	nsubjpass	CEBPG,correlated
R2063	T3233	T3231	punct	", ",CEBPG
R2064	T3234	T3231	cc	nor,CEBPG
R2065	T3235	T3231	conj	XRCC1,CEBPG
R2066	T3236	T3235	punct	", ",XRCC1
R2067	T3237	T3235	conj	ERCC5,XRCC1
R2068	T3238	T3237	punct	", ",ERCC5
R2069	T3239	T3237	conj	GSTP1,ERCC5
R2070	T3240	T3239	punct	", ",GSTP1
R2071	T3241	T3239	conj	SOD1,GSTP1
R2072	T3242	T3241	cc	or,SOD1
R2073	T3243	T3241	conj	GPX1,SOD1
R2074	T3244	T3232	auxpass	was,correlated
R2075	T3245	T3232	advmod	significantly,correlated
R2076	T3246	T3232	prep	with,correlated
R2077	T3247	T3246	pobj	age,with
R2078	T3248	T3247	punct	", ",age
R2079	T3249	T3247	conj	gender,age
R2080	T3250	T3249	punct	", ",gender
R2081	T3251	T3249	cc	or,gender
R2082	T3252	T3253	compound	smoking,history
R2083	T3253	T3249	conj	history,gender
R2084	T3254	T3232	prep	in,correlated
R2085	T3255	T3256	amod	non-BC,individuals
R2086	T3256	T3254	pobj	individuals,in
R2087	T3257	T3256	punct	", ",individuals
R2088	T3258	T3259	compound	BC,individuals
R2089	T3259	T3256	conj	individuals,individuals
R2090	T3260	T3259	punct	", ",individuals
R2091	T3261	T3259	cc	or,individuals
R2092	T3262	T3263	det	the,group
R2093	T3263	T3259	conj	group,individuals
R2094	T3264	T3263	amod	combined,group
R2095	T3265	T3232	punct	.,correlated
R2096	T3267	T3268	prep	In,accounts
R2097	T3269	T3270	amod	non-BC,individuals
R2098	T3270	T3267	pobj	individuals,In
R2099	T3271	T3268	punct	", ",accounts
R2100	T3272	T3268	prep	based,accounts
R2101	T3273	T3272	prep	on,based
R2102	T3274	T3275	det	the,values
R2103	T3275	T3273	pobj	values,on
R2104	T3276	T3275	compound	r2,values
R2105	T3277	T3275	prep	from,values
R2106	T3278	T3279	poss	Pearson,analysis
R2108	T3280	T3278	case	's,Pearson
R2109	T3281	T3279	compound	correlation,analysis
R2110	T3282	T3268	punct	", ",accounts
R2111	T3283	T3268	nsubj	CEBPG,accounts
R2112	T3284	T3268	prep	for,accounts
R2113	T3285	T3284	pobj	much,for
R2114	T3286	T3285	prep	of,much
R2115	T3287	T3288	det	the,variance
R2116	T3288	T3286	pobj	variance,of
R2117	T3289	T3288	prep	in,variance
R2118	T3290	T3289	pobj	expression,in
R2119	T3291	T3290	prep	of,expression
R2120	T3292	T3291	pobj	XRCC1,of
R2121	T3293	T3294	punct	(,%
R2122	T3294	T3292	parataxis	%,XRCC1
R2123	T3295	T3294	nummod	69,%
R2124	T3296	T3294	punct	),%
R2125	T3297	T3292	punct	", ",XRCC1
R2126	T3298	T3292	conj	ERCC5,XRCC1
R2127	T3299	T3300	punct	(,%
R2128	T3300	T3298	parataxis	%,ERCC5
R2129	T3301	T3300	nummod	62,%
R2130	T3302	T3300	punct	),%
R2131	T3303	T3298	punct	", ",ERCC5
R2132	T3304	T3298	conj	GSTP1,ERCC5
R2133	T3305	T3306	punct	(,%
R2134	T3306	T3304	parataxis	%,GSTP1
R2135	T3307	T3306	nummod	55,%
R2136	T3308	T3306	punct	),%
R2137	T3309	T3304	punct	", ",GSTP1
R2138	T3310	T3304	conj	SOD1,GSTP1
R2139	T3311	T3312	punct	(,%
R2140	T3312	T3310	parataxis	%,SOD1
R2141	T3313	T3312	nummod	44,%
R2142	T3314	T3312	punct	),%
R2143	T3315	T3310	punct	", ",SOD1
R2144	T3316	T3310	cc	and,SOD1
R2145	T3317	T3310	conj	GPX1,SOD1
R2146	T3318	T3319	punct	(,%
R2147	T3319	T3317	parataxis	%,GPX1
R2148	T3320	T3319	nummod	52,%
R2149	T3321	T3319	punct	),%
R2150	T3322	T3268	punct	.,accounts
R2151	T3324	T3325	nsubj	E2F1,accounts
R2152	T3326	T3325	prep	for,accounts
R2153	T3327	T3326	pobj	some,for
R2154	T3328	T3327	prep	of,some
R2155	T3329	T3330	det	the,variance
R2156	T3330	T3328	pobj	variance,of
R2157	T3331	T3330	amod	remaining,variance
R2158	T3332	T3325	punct	.,accounts
R2159	T3334	T3335	prep	For,correlated
R2160	T3336	T3334	pobj	example,For
R2161	T3337	T3335	punct	", ",correlated
R2162	T3338	T3339	advmod	when,assessed
R2163	T3339	T3335	advcl	assessed,correlated
R2164	T3340	T3339	nsubjpass	samples,assessed
R2165	T3341	T3340	prep	from,samples
R2166	T3342	T3343	predet	all,individuals
R2167	T3343	T3341	pobj	individuals,from
R2168	T3344	T3343	nummod	49,individuals
R2169	T3345	T3343	amod	non-BC,individuals
R2170	T3346	T3343	cc	and,individuals
R2171	T3347	T3348	compound	BC,individuals
R2172	T3348	T3343	conj	individuals,individuals
R2173	T3349	T3339	auxpass	were,assessed
R2174	T3350	T3339	prep	as,assessed
R2175	T3351	T3352	det	a,group
R2176	T3352	T3350	pobj	group,as
R2177	T3353	T3352	amod	single,group
R2178	T3354	T3335	punct	", ",correlated
R2179	T3355	T3335	nsubjpass	E2F1,correlated
R2180	T3356	T3335	auxpass	was,correlated
R2181	T3357	T3335	advmod	significantly,correlated
R2182	T3358	T3335	prep	with,correlated
R2183	T3359	T3358	pobj	ERCC5,with
R2184	T3360	T3359	punct	", ",ERCC5
R2185	T3361	T3359	conj	GSTP1,ERCC5
R2186	T3362	T3361	cc	and,GSTP1
R2187	T3363	T3361	conj	SOD1,GSTP1
R2188	T3364	T3365	punct	(,Table
R2189	T3365	T3335	parataxis	Table,correlated
R2190	T3366	T3365	nummod	4,Table
R2191	T3367	T3365	punct	),Table
R2192	T3368	T3335	punct	.,correlated
R2193	T3370	T3371	advmod	Further,correlated
R2194	T3372	T3371	punct	", ",correlated
R2195	T3373	T3371	prep	in,correlated
R2196	T3374	T3375	amod	non-BC,individuals
R2197	T3375	T3373	pobj	individuals,in
R2198	T3376	T3371	punct	", ",correlated
R2199	T3377	T3371	nsubjpass	E2F1,correlated
R2200	T3378	T3371	auxpass	was,correlated
R2201	T3379	T3371	prep	with,correlated
R2202	T3380	T3379	pobj	GSTP1,with
R2203	T3381	T3382	punct	(,Fig.
R2204	T3382	T3371	parataxis	Fig.,correlated
R2205	T3383	T3382	nummod	1c,Fig.
R2206	T3384	T3382	punct	),Fig.
R2207	T3385	T3371	cc	and,correlated
R2208	T3386	T3387	det	the,correlation
R2209	T3387	T3388	nsubj	correlation,was
R2210	T3388	T3371	conj	was,correlated
R2211	T3389	T3388	acomp	lower,was
R2212	T3390	T3388	prep	in,was
R2213	T3391	T3392	compound	BC,individuals
R2214	T3392	T3390	pobj	individuals,in
R2215	T3393	T3371	punct	.,correlated
R2216	T3395	T3396	advmod	However,was
R2217	T3397	T3396	punct	", ",was
R2218	T3398	T3399	det	the,difference
R2219	T3399	T3396	nsubj	difference,was
R2220	T3400	T3399	prep	in,difference
R2221	T3401	T3400	pobj	correlation,in
R2222	T3402	T3399	prep	between,difference
R2223	T3403	T3404	amod	non-BC,individuals
R2224	T3404	T3402	pobj	individuals,between
R2225	T3405	T3404	cc	and,individuals
R2226	T3406	T3407	compound	BC,individuals
R2227	T3407	T3404	conj	individuals,individuals
R2228	T3408	T3396	neg	not,was
R2229	T3409	T3396	acomp	significant,was
R2230	T3410	T3396	punct	.,was
R2231	T3412	T3413	nsubjpass	None,correlated
R2232	T3414	T3412	prep	of,None
R2233	T3415	T3416	det	the,factors
R2235	T3417	T3416	amod	other,factors
R2236	T3418	T3416	compound	transcription,factors
R2237	T3419	T3413	auxpass	were,correlated
R2238	T3420	T3413	prep	with,correlated
R2239	T3421	T3420	pobj	XRCC1,with
R2240	T3422	T3421	punct	", ",XRCC1
R2241	T3423	T3421	conj	ERCC5,XRCC1
R2242	T3424	T3423	punct	", ",ERCC5
R2243	T3425	T3423	conj	GSTP1,ERCC5
R2244	T3426	T3425	punct	", ",GSTP1
R2245	T3427	T3425	conj	SOD1,GSTP1
R2246	T3428	T3427	punct	", ",SOD1
R2247	T3429	T3427	cc	or,SOD1
R2248	T3430	T3427	conj	GPX1,SOD1
R2249	T3431	T3432	punct	(,f
R2250	T3432	T3413	parataxis	f,correlated
R2251	T3433	T3432	nmod	Fig.,f
R2252	T3434	T3432	nummod	1a,f
R2253	T3435	T3432	punct	",",f
R2254	T3436	T3432	nmod	d,f
R2255	T3437	T3432	punct	",",f
R2256	T3438	T3432	nmod	e,f
R2257	T3439	T3432	punct	",",f
R2258	T3440	T3432	punct	),f
R2259	T3441	T3413	punct	.,correlated
R2260	T3468	T3467	prep	of,Comparison
R2261	T3469	T3470	compound	gene,expression
R2262	T3470	T3468	pobj	expression,of
R2263	T3471	T3467	prep	with,Comparison
R2264	T3472	T3473	amod	demographic,characteristics
R2265	T3473	T3471	pobj	characteristics,with
R2266	T3475	T3476	nsubjpass	E2F1,correlated
R2267	T3477	T3475	cc	and,E2F1
R2268	T3478	T3475	conj	GSTZ1,E2F1
R2269	T3479	T3475	appos	each,E2F1
R2270	T3480	T3476	auxpass	were,correlated
R2271	T3481	T3476	advmod	positively,correlated
R2272	T3482	T3476	prep	with,correlated
R2273	T3483	T3482	pobj	age,with
R2274	T3484	T3476	punct	.,correlated
R2275	T3486	T3487	nsubj	GSTM1,was
R2276	T3488	T3486	punct	-,GSTM1
R2277	T3489	T3486	nummod	5,GSTM1
R2278	T3490	T3491	det	the,gene
R2279	T3491	T3487	attr	gene,was
R2280	T3492	T3491	amod	only,gene
R2281	T3493	T3491	prep	with,gene
R2282	T3494	T3495	det	a,difference
R2283	T3495	T3493	pobj	difference,with
R2284	T3496	T3495	prep	in,difference
R2285	T3497	T3496	pobj	expression,in
R2286	T3498	T3495	prep	by,difference
R2287	T3499	T3498	pobj	gender,by
R2288	T3500	T3487	punct	.,was
R2289	T3502	T3503	expl	There,was
R2290	T3504	T3505	det	a,difference
R2291	T3505	T3503	attr	difference,was
R2292	T3506	T3505	prep	in,difference
R2293	T3507	T3508	compound	ERCC2,expression
R2294	T3508	T3506	pobj	expression,in
R2295	T3509	T3505	prep	between,difference
R2296	T3510	T3511	amod	former,smokers
R2298	T3512	T3510	cc	and,former
R2299	T3513	T3510	conj	never,former
R2300	T3514	T3503	punct	.,was
R2301	T4175	T4176	prep	In,tested
R2302	T4177	T4178	det	this,study
R2303	T4178	T4175	pobj	study,In
R2304	T4179	T4176	punct	", ",tested
R2305	T4180	T4176	nsubj	we,tested
R2306	T4181	T4182	nummod	two,hypotheses
R2307	T4182	T4176	dobj	hypotheses,tested
R2308	T4183	T4176	punct	.,tested
R2309	T4185	T4186	advmod	First,is
R2310	T4187	T4186	punct	", ",is
R2311	T4188	T4186	mark	that,is
R2312	T4189	T4186	expl	there,is
R2313	T4190	T4191	amod	inter-individual,variation
R2314	T4191	T4186	attr	variation,is
R2315	T4192	T4186	prep	in,is
R2316	T4193	T4192	pobj	regulation,in
R2317	T4194	T4193	prep	of,regulation
R2318	T4195	T4196	amod	key,genes
R2319	T4196	T4194	pobj	genes,of
R2320	T4197	T4196	nmod	antioxidant,genes
R2321	T4198	T4197	cc	and,antioxidant
R2322	T4199	T4200	compound	DNA,repair
R2323	T4200	T4197	conj	repair,antioxidant
R2324	T4201	T4193	prep	by,regulation
R2325	T4202	T4203	nummod	one,factors
R2326	T4203	T4201	pobj	factors,by
R2327	T4204	T4202	cc	or,one
R2328	T4205	T4202	conj	more,one
R2329	T4206	T4203	compound	transcription,factors
R2330	T4207	T4186	punct	.,is
R2331	T4209	T4210	advmod	Second,selected
R2332	T4211	T4210	punct	", ",selected
R2333	T4212	T4210	mark	that,selected
R2334	T4213	T4210	nsubjpass	individuals,selected
R2335	T4214	T4213	prep	with,individuals
R2336	T4215	T4216	amod	sub-optimal,regulation
R2337	T4216	T4214	pobj	regulation,with
R2338	T4217	T4210	auxpass	are,selected
R2339	T4218	T4210	prep	for,selected
R2340	T4219	T4218	pobj	development,for
R2341	T4220	T4219	prep	of,development
R2342	T4221	T4220	pobj	BC,of
R2343	T4222	T4223	mark	if,smoke
R2344	T4223	T4210	advcl	smoke,selected
R2345	T4224	T4223	nsubj	they,smoke
R2346	T4225	T4223	dobj	cigarettes,smoke
R2347	T4226	T4210	punct	.,selected
R2348	T4228	T4229	det	These,hypotheses
R2349	T4229	T4230	nsubjpass	hypotheses,supported
R2350	T4231	T4230	auxpass	are,supported
R2351	T4232	T4230	agent	by,supported
R2352	T4233	T4234	det	the,findings
R2353	T4234	T4232	pobj	findings,by
R2354	T4235	T4236	mark	that,correlated
R2355	T4236	T4234	advcl	correlated,findings
R2356	T4237	T4238	meta	a,was
R2357	T4238	T4236	ccomp	was,correlated
R2358	T4239	T4237	punct	),a
R2359	T4240	T4238	expl	there,was
R2360	T4241	T4242	amod	large,variation
R2361	T4242	T4238	attr	variation,was
R2362	T4243	T4242	amod	inter-individual,variation
R2363	T4244	T4238	prep	in,was
R2364	T4245	T4246	compound	transcript,levels
R2365	T4246	T4244	pobj	levels,in
R2366	T4247	T4246	prep	of,levels
R2367	T4248	T4247	pobj	CEBPG,of
R2368	T4249	T4248	cc	and,CEBPG
R2369	T4250	T4248	conj	each,CEBPG
R2370	T4251	T4250	prep	of,each
R2371	T4252	T4253	det	the,genes
R2372	T4253	T4251	pobj	genes,of
R2373	T4254	T4253	compound	target,genes
R2374	T4255	T4244	cc	and,in
R2375	T4256	T4244	conj	in,in
R2376	T4257	T4258	amod	non-BC,individuals
R2377	T4258	T4256	pobj	individuals,in
R2378	T4259	T4236	punct	", ",correlated
R2379	T4260	T4236	meta	b,correlated
R2380	T4261	T4260	punct	),b
R2381	T4262	T4263	compound	CEBPG,values
R2382	T4263	T4236	nsubjpass	values,correlated
R2383	T4264	T4265	compound	transcript,abundance
R2384	T4265	T4263	compound	abundance,values
R2385	T4266	T4236	auxpass	were,correlated
R2386	T4267	T4236	advmod	significantly,correlated
R2387	T4268	T4236	prep	by,correlated
R2388	T4269	T4270	amod	bivariate,analysis
R2389	T4270	T4268	pobj	analysis,by
R2390	T4271	T4236	prep	with,correlated
R2391	T4272	T4273	det	the,values
R2393	T4274	T4275	compound	transcript,abundance
R2394	T4275	T4273	compound	abundance,values
R2395	T4276	T4273	prep	of,values
R2396	T4277	T4278	nummod	four,genes
R2397	T4278	T4276	pobj	genes,of
R2398	T4279	T4278	amod	key,genes
R2399	T4280	T4278	nmod	antioxidant,genes
R2400	T4281	T4280	cc	and,antioxidant
R2401	T4282	T4283	compound	DNA,repair
R2402	T4283	T4280	conj	repair,antioxidant
R2403	T4284	T4236	prep	in,correlated
R2404	T4285	T4286	amod	non-BC,individuals
R2405	T4286	T4284	pobj	individuals,in
R2406	T4287	T4236	punct	", ",correlated
R2407	T4288	T4236	cc	and,correlated
R2408	T4289	T4290	meta	c,was
R2409	T4290	T4236	conj	was,correlated
R2410	T4291	T4289	punct	),c
R2411	T4292	T4290	mark	that,was
R2412	T4293	T4290	expl	there,was
R2413	T4294	T4295	det	no,correlation
R2414	T4295	T4290	attr	correlation,was
R2415	T4296	T4295	prep	between,correlation
R2416	T4297	T4296	pobj	CEBPG,between
R2417	T4298	T4297	cc	and,CEBPG
R2418	T4299	T4300	det	these,genes
R2419	T4300	T4297	conj	genes,CEBPG
R2420	T4301	T4290	prep	in,was
R2421	T4302	T4303	compound	BC,individuals
R2422	T4303	T4301	pobj	individuals,in
R2423	T4304	T4230	punct	.,supported
R2424	T4306	T4307	det	These,results
R2425	T4307	T4308	nsubj	results,support
R2426	T4309	T4310	det	the,hypothesis
R2427	T4310	T4308	dobj	hypothesis,support
R2428	T4311	T4312	mark	that,regulated
R2429	T4312	T4310	acl	regulated,hypothesis
R2430	T4313	T4312	nsubjpass	each,regulated
R2431	T4314	T4313	prep	of,each
R2432	T4315	T4316	det	the,genes
R2433	T4316	T4314	pobj	genes,of
R2434	T4317	T4316	nmod	antioxidant,genes
R2435	T4318	T4317	cc	or,antioxidant
R2436	T4319	T4320	compound	DNA,repair
R2437	T4320	T4317	conj	repair,antioxidant
R2438	T4321	T4316	acl	correlated,genes
R2439	T4322	T4321	prep	with,correlated
R2440	T4323	T4322	pobj	CEBPG,with
R2441	T4324	T4321	prep	in,correlated
R2442	T4325	T4326	amod	non-BC,individuals
R2443	T4326	T4324	pobj	individuals,in
R2444	T4327	T4312	auxpass	is,regulated
R2445	T4328	T4312	agent	by,regulated
R2446	T4329	T4328	pobj	CEBPG,by
R2447	T4330	T4308	punct	.,support
R2448	T4332	T4333	nsubjpass	This,supported
R2449	T4334	T4333	auxpass	is,supported
R2450	T4335	T4333	agent	by,supported
R2451	T4336	T4337	det	the,specificity
R2452	T4337	T4335	pobj	specificity,by
R2453	T4338	T4337	prep	of,specificity
R2454	T4339	T4340	det	the,correlation
R2455	T4340	T4338	pobj	correlation,of
R2456	T4341	T4340	compound	CEBPG,correlation
R2457	T4342	T4333	punct	.,supported
R2458	T4344	T4345	advmod	That,is
R2459	T4345	T4346	advmod	is,was
R2460	T4347	T4346	punct	", ",was
R2461	T4348	T4346	expl	there,was
R2462	T4349	T4346	attr	lack,was
R2463	T4350	T4349	prep	of,lack
R2464	T4351	T4350	pobj	correlation,of
R2465	T4352	T4351	prep	between,correlation
R2466	T4353	T4352	pobj	any,between
R2467	T4354	T4353	prep	of,any
R2468	T4355	T4356	det	the,factors
R2469	T4356	T4354	pobj	factors,of
R2470	T4357	T4356	amod	other,factors
R2471	T4358	T4356	nummod	five,factors
R2472	T4359	T4356	compound	transcription,factors
R2473	T4360	T4356	acl	assessed,factors
R2474	T4361	T4353	cc	and,any
R2475	T4362	T4363	det	these,genes
R2476	T4363	T4353	conj	genes,any
R2477	T4364	T4363	compound	target,genes
R2478	T4365	T4346	punct	.,was
R2479	T4367	T4368	prep	Of,is
R2480	T4369	T4370	amod	particular,note
R2481	T4370	T4367	pobj	note,Of
R2482	T4371	T4372	det	the,lack
R2483	T4372	T4368	nsubj	lack,is
R2484	T4373	T4372	prep	of,lack
R2485	T4374	T4373	pobj	correlation,of
R2486	T4375	T4374	prep	of,correlation
R2487	T4376	T4377	det	the,genes
R2488	T4377	T4375	pobj	genes,of
R2489	T4378	T4377	compound	target,genes
R2490	T4379	T4374	prep	with,correlation
R2491	T4380	T4379	pobj	CEBPB,with
R2492	T4381	T4380	punct	", ",CEBPB
R2493	T4382	T4383	dep	which,binds
R2494	T4383	T4380	relcl	binds,CEBPB
R2495	T4384	T4383	prep	to,binds
R2496	T4385	T4386	det	the,site
R2498	T4387	T4386	amod	same,site
R2499	T4388	T4386	compound	recognition,site
R2500	T4389	T4386	prep	as,site
R2501	T4390	T4389	pobj	CEBPG,as
R2502	T4391	T4383	punct	", ",binds
R2503	T4392	T4383	cc	and,binds
R2504	T4393	T4383	conj	shares,binds
R2505	T4394	T4395	poss	its,site
R2506	T4395	T4393	dobj	site,shares
R2507	T4396	T4395	compound	recognition,site
R2508	T4397	T4393	prep	within,shares
R2509	T4398	T4397	pobj	each,within
R2510	T4399	T4398	prep	of,each
R2511	T4400	T4401	det	the,genes
R2512	T4401	T4399	pobj	genes,of
R2513	T4402	T4401	nmod	antioxidant,genes
R2514	T4403	T4402	cc	or,antioxidant
R2515	T4404	T4405	compound	DNA,repair
R2516	T4405	T4402	conj	repair,antioxidant
R2517	T4406	T4368	punct	.,is
R2518	T4408	T4409	advmod	However,are
R2519	T4410	T4409	punct	", ",are
R2520	T4411	T4409	expl	there,are
R2521	T4412	T4413	amod	alternative,explanations
R2522	T4413	T4409	attr	explanations,are
R2523	T4414	T4413	prep	for,explanations
R2524	T4415	T4416	det	the,correlation
R2525	T4416	T4414	pobj	correlation,for
R2526	T4417	T4416	amod	observed,correlation
R2527	T4418	T4416	prep	of,correlation
R2528	T4419	T4418	pobj	CEBPG,of
R2529	T4420	T4416	prep	with,correlation
R2530	T4421	T4422	nmod	antioxidant,genes
R2531	T4422	T4420	pobj	genes,with
R2532	T4423	T4421	cc	and,antioxidant
R2533	T4424	T4425	compound	DNA,repair
R2534	T4425	T4421	conj	repair,antioxidant
R2535	T4426	T4416	prep	in,correlation
R2536	T4427	T4428	amod	non-BC,individuals
R2537	T4428	T4426	pobj	individuals,in
R2538	T4429	T4409	punct	.,are
R2539	T4431	T4432	nummod	One,possibility
R2540	T4432	T4433	nsubj	possibility,is
R2541	T4434	T4435	mark	that,regulated
R2542	T4435	T4433	ccomp	regulated,is
R2543	T4436	T4435	nsubjpass	CEBPG,regulated
R2544	T4437	T4436	cc	and,CEBPG
R2545	T4438	T4436	conj	each,CEBPG
R2546	T4439	T4438	prep	of,each
R2547	T4440	T4441	det	the,genes
R2548	T4441	T4439	pobj	genes,of
R2549	T4442	T4441	amod	correlated,genes
R2550	T4443	T4441	nmod	antioxidant,genes
R2551	T4444	T4443	cc	or,antioxidant
R2552	T4445	T4446	compound	DNA,repair
R2553	T4446	T4443	conj	repair,antioxidant
R2554	T4447	T4435	auxpass	is,regulated
R2555	T4448	T4435	agent	by,regulated
R2556	T4449	T4450	det	a,factor
R2557	T4450	T4448	pobj	factor,by
R2558	T4451	T4450	compound	transcription,factor
R2559	T4452	T4453	dep	that,is
R2560	T4453	T4450	relcl	is,factor
R2561	T4454	T4455	advmod	as,yet
R2562	T4455	T4453	advmod	yet,is
R2563	T4456	T4453	acomp	undiscovered,is
R2564	T4457	T4453	punct	", ",is
R2565	T4458	T4453	cc	and,is
R2566	T4459	T4458	punct	/,and
R2567	T4460	T4458	cc	or,and
R2568	T4461	T4453	conj	has,is
R2569	T4462	T4463	det	a,site
R2570	T4463	T4461	dobj	site,has
R2571	T4464	T4463	compound	recognition,site
R2572	T4465	T4466	dep	that,known
R2573	T4466	T4463	relcl	known,site
R2574	T4467	T4466	auxpass	is,known
R2575	T4468	T4466	neg	not,known
R2576	T4469	T4466	advmod	yet,known
R2577	T4470	T4466	cc	and,known
R2578	T4471	T4466	conj	was,known
R2579	T4472	T4471	neg	not,was
R2580	T4473	T4471	prep	in,was
R2581	T4474	T4475	det	the,database
R2583	T4476	T4475	compound	Genomatix,database
R2584	T4477	T4475	compound	software,database
R2585	T4478	T4433	punct	.,is
R2586	T4480	T4481	expl	There,is
R2587	T4482	T4481	advmod	also,is
R2588	T4483	T4484	amod	more,one
R2589	T4484	T4486	nummod	one,explanation
R2590	T4485	T4484	quantmod	than,one
R2591	T4486	T4481	attr	explanation,is
R2592	T4487	T4486	amod	possible,explanation
R2593	T4488	T4486	prep	for,explanation
R2594	T4489	T4490	det	the,lack
R2595	T4490	T4488	pobj	lack,for
R2596	T4491	T4490	amod	observed,lack
R2597	T4492	T4490	prep	of,lack
R2598	T4493	T4492	pobj	correlation,of
R2599	T4494	T4493	prep	between,correlation
R2600	T4495	T4494	pobj	CEBPG,between
R2601	T4496	T4495	cc	and,CEBPG
R2602	T4497	T4498	nmod	antioxidant,genes
R2603	T4498	T4495	conj	genes,CEBPG
R2604	T4499	T4497	cc	or,antioxidant
R2605	T4500	T4501	compound	DNA,repair
R2606	T4501	T4497	conj	repair,antioxidant
R2607	T4502	T4490	prep	in,lack
R2608	T4503	T4504	compound	BC,individuals
R2609	T4504	T4502	pobj	individuals,in
R2610	T4505	T4481	punct	.,is
R2611	T4507	T4508	prep	For,matched
R2612	T4509	T4507	pobj	example,For
R2613	T4510	T4508	punct	", ",matched
R2614	T4511	T4512	det	the,groups
R2615	T4512	T4508	nsubjpass	groups,matched
R2616	T4513	T4514	amod	non-BC,individual
R2617	T4514	T4512	nmod	individual,groups
R2618	T4515	T4514	cc	and,individual
R2619	T4516	T4514	conj	BC,individual
R2620	T4517	T4516	amod	individual,BC
R2621	T4518	T4508	auxpass	are,matched
R2622	T4519	T4508	neg	not,matched
R2623	T4520	T4508	advmod	perfectly,matched
R2624	T4521	T4508	prep	with,matched
R2625	T4522	T4521	pobj	respect,with
R2626	T4523	T4522	prep	to,respect
R2627	T4524	T4523	pobj	age,to
R2628	T4525	T4524	punct	", ",age
R2629	T4526	T4524	conj	gender,age
R2630	T4527	T4526	cc	or,gender
R2631	T4528	T4529	compound	smoking,history
R2632	T4529	T4526	conj	history,gender
R2633	T4530	T4531	punct	(,Table
R2634	T4531	T4508	parataxis	Table,matched
R2635	T4532	T4531	nummod	1,Table
R2636	T4533	T4531	punct	),Table
R2637	T4534	T4508	cc	and,matched
R2638	T4535	T4536	nsubj	each,contribute
R2639	T4536	T4508	conj	contribute,matched
R2640	T4537	T4535	prep	of,each
R2641	T4538	T4539	det	these,factors
R2642	T4539	T4537	pobj	factors,of
R2643	T4540	T4536	aux	could,contribute
R2644	T4541	T4536	prep	to,contribute
R2645	T4542	T4543	det	the,difference
R2646	T4543	T4541	pobj	difference,to
R2647	T4544	T4543	amod	observed,difference
R2648	T4545	T4543	prep	in,difference
R2649	T4546	T4545	pobj	correlation,in
R2650	T4547	T4546	prep	between,correlation
R2651	T4548	T4547	pobj	groups,between
R2652	T4549	T4508	punct	.,matched
R2653	T4551	T4552	advmod	However,argues
R2654	T4553	T4552	punct	", ",argues
R2655	T4554	T4555	det	the,lack
R2656	T4555	T4552	nsubj	lack,argues
R2657	T4556	T4555	prep	of,lack
R2658	T4557	T4556	pobj	association,of
R2659	T4558	T4557	prep	of,association
R2660	T4559	T4560	compound	transcript,abundance
R2661	T4560	T4561	compound	abundance,level
R2662	T4561	T4558	pobj	level,of
R2663	T4562	T4561	prep	for,level
R2664	T4563	T4562	pobj	CEBPG,for
R2665	T4564	T4563	punct	", ",CEBPG
R2666	T4565	T4563	conj	XRCC1,CEBPG
R2667	T4566	T4565	punct	", ",XRCC1
R2668	T4567	T4565	conj	ERCC5,XRCC1
R2669	T4568	T4567	punct	", ",ERCC5
R2670	T4569	T4567	conj	GSTP1,ERCC5
R2671	T4570	T4569	punct	", ",GSTP1
R2672	T4571	T4569	conj	SOD1,GSTP1
R2673	T4572	T4571	punct	", ",SOD1
R2674	T4573	T4571	cc	or,SOD1
R2675	T4574	T4571	conj	GPX1,SOD1
R2676	T4575	T4557	prep	with,association
R2677	T4576	T4575	pobj	age,with
R2678	T4577	T4576	punct	", ",age
R2679	T4578	T4576	conj	gender,age
R2680	T4579	T4578	cc	or,gender
R2681	T4580	T4581	compound	smoking,history
R2682	T4581	T4578	conj	history,gender
R2683	T4582	T4552	prep	against,argues
R2684	T4583	T4584	predet	such,explanation
R2685	T4584	T4582	pobj	explanation,against
R2686	T4585	T4584	det	an,explanation
R2687	T4586	T4552	punct	.,argues
R2688	T4588	T4589	nummod	One,way
R2689	T4589	T4590	nsubj	way,is
R2690	T4591	T4592	aux	to,examine
R2691	T4592	T4589	advcl	examine,way
R2692	T4593	T4594	det	this,possibility
R2693	T4594	T4592	dobj	possibility,examine
R2694	T4595	T4590	prep	through,is
R2695	T4596	T4597	amod	additional,studies
R2696	T4597	T4595	pobj	studies,through
R2697	T4598	T4597	punct	", ",studies
R2698	T4599	T4597	amod	larger,studies
R2699	T4600	T4597	punct	", ",studies
R2700	T4601	T4602	advmod	more,closely
R2701	T4602	T4603	advmod	closely,matched
R2702	T4603	T4597	amod	matched,studies
R2703	T4604	T4590	punct	.,is
R2704	T4606	T4607	det	Another,explanation
R2705	T4607	T4609	nsubj	explanation,is
R2706	T4608	T4607	amod	possible,explanation
R2707	T4610	T4611	mark	that,resulted
R2708	T4611	T4609	ccomp	resulted,is
R2709	T4612	T4613	det	any,differences
R2710	T4613	T4611	nsubj	differences,resulted
R2711	T4614	T4613	prep	in,differences
R2712	T4615	T4614	pobj	NBEC,in
R2713	T4616	T4615	prep	from,NBEC
R2714	T4617	T4618	compound	BC,individuals
R2715	T4618	T4616	pobj	individuals,from
R2716	T4619	T4618	prep	compared,individuals
R2717	T4620	T4619	prep	to,compared
R2718	T4621	T4622	amod	non-BC,individuals
R2719	T4622	T4620	pobj	individuals,to
R2720	T4623	T4611	prep	from,resulted
R2721	T4624	T4623	pobj	development,from
R2722	T4625	T4624	prep	of,development
R2723	T4626	T4625	pobj	BC,of
R2724	T4627	T4611	punct	", ",resulted
R2725	T4628	T4629	advmod	instead,of
R2726	T4629	T4611	prep	of,resulted
R2727	T4630	T4629	pcomp	being,of
R2728	T4631	T4632	det	a,cause
R2729	T4632	T4630	attr	cause,being
R2730	T4633	T4632	amod	hereditary,cause
R2731	T4634	T4632	prep	of,cause
R2732	T4635	T4636	amod	increased,risk
R2733	T4636	T4634	pobj	risk,of
R2734	T4637	T4636	prep	for,risk
R2735	T4638	T4637	pobj	cancer,for
R2736	T4639	T4609	punct	.,is
R2737	T4641	T4642	det	The,way
R2738	T4642	T4644	nsubj	way,be
R2739	T4643	T4642	amod	best,way
R2740	T4645	T4646	aux	to,determine
R2741	T4646	T4642	advcl	determine,way
R2742	T4647	T4646	dobj	this,determine
R2743	T4648	T4644	aux	will,be
R2744	T4649	T4650	aux	to,conduct
R2745	T4650	T4644	xcomp	conduct,be
R2746	T4651	T4652	det	a,study
R2747	T4652	T4650	dobj	study,conduct
R2748	T4653	T4652	amod	prospective,study
R2749	T4654	T4644	punct	.,be
R2750	T4656	T4657	prep	In,monitored
R2751	T4658	T4659	predet	such,study
R2752	T4659	T4656	pobj	study,In
R2753	T4660	T4659	det	a,study
R2754	T4661	T4657	punct	", ",monitored
R2755	T4662	T4657	nsubjpass	individuals,monitored
R2756	T4663	T4662	acl	matched,individuals
R2757	T4664	T4663	prep	for,matched
R2758	T4665	T4666	compound	smoking,history
R2759	T4666	T4664	pobj	history,for
R2760	T4667	T4657	aux	will,monitored
R2761	T4668	T4657	auxpass	be,monitored
R2762	T4669	T4657	prep	for,monitored
R2763	T4670	T4669	pobj	development,for
R2764	T4671	T4670	prep	of,development
R2765	T4672	T4671	pobj	BC,of
R2766	T4673	T4657	prep	over,monitored
R2767	T4674	T4673	pobj	time,over
R2768	T4675	T4657	punct	.,monitored
R2769	T4677	T4678	det	The,correlation
R2770	T4678	T4679	nsubjpass	correlation,assessed
R2771	T4680	T4678	prep	of,correlation
R2772	T4681	T4682	compound	transcript,abundance
R2773	T4682	T4683	compound	abundance,values
R2774	T4683	T4680	pobj	values,of
R2775	T4684	T4683	prep	for,values
R2776	T4685	T4684	pobj	CEBPG,for
R2777	T4686	T4683	amod	relative,values
R2778	T4687	T4686	prep	to,relative
R2779	T4688	T4689	compound	transcript,abundance
R2780	T4689	T4690	compound	abundance,values
R2781	T4690	T4687	pobj	values,to
R2782	T4691	T4690	prep	for,values
R2783	T4692	T4691	pobj	each,for
R2784	T4693	T4692	prep	of,each
R2785	T4694	T4695	det	the,genes
R2786	T4695	T4693	pobj	genes,of
R2787	T4696	T4695	nmod	antioxidant,genes
R2788	T4697	T4696	cc	or,antioxidant
R2789	T4698	T4699	compound	DNA,repair
R2790	T4699	T4696	conj	repair,antioxidant
R2791	T4700	T4679	aux	will,assessed
R2792	T4701	T4679	auxpass	be,assessed
R2793	T4702	T4679	punct	.,assessed
R2794	T4704	T4705	nsubjpass	It,expected
R2795	T4706	T4705	auxpass	is,expected
R2796	T4707	T4708	mark	that,be
R2797	T4708	T4705	ccomp	be,expected
R2798	T4709	T4710	det	the,incidence
R2799	T4710	T4708	nsubj	incidence,be
R2800	T4711	T4710	amod	greatest,incidence
R2801	T4712	T4710	prep	of,incidence
R2802	T4713	T4712	pobj	BC,of
R2803	T4714	T4708	aux	will,be
R2804	T4715	T4708	prep	among,be
R2805	T4716	T4717	det	the,smokers
R2806	T4717	T4715	pobj	smokers,among
R2807	T4718	T4717	amod	heaviest,smokers
R2808	T4719	T4705	punct	.,expected
R2809	T4721	T4722	prep	Among,expected
R2810	T4723	T4724	det	the,smokers
R2812	T4725	T4724	amod	matched,smokers
R2813	T4726	T4724	amod	heaviest,smokers
R2814	T4727	T4722	punct	", ",expected
R2815	T4728	T4722	nsubjpass	it,expected
R2816	T4729	T4722	auxpass	is,expected
R2817	T4730	T4731	mark	that,correlated
R2818	T4731	T4722	ccomp	correlated,expected
R2819	T4732	T4731	nsubjpass	CEBPG,correlated
R2820	T4733	T4731	aux	will,correlated
R2821	T4734	T4731	auxpass	be,correlated
R2822	T4735	T4731	advmod	significantly,correlated
R2823	T4736	T4731	prep	with,correlated
R2824	T4737	T4736	pobj	each,with
R2825	T4738	T4737	prep	of,each
R2826	T4739	T4740	det	the,genes
R2827	T4740	T4738	pobj	genes,of
R2828	T4741	T4740	nmod	antioxidant,genes
R2829	T4742	T4741	cc	or,antioxidant
R2830	T4743	T4744	compound	DNA,repair
R2831	T4744	T4741	conj	repair,antioxidant
R2832	T4745	T4731	prep	among,correlated
R2833	T4746	T4747	det	the,individuals
R2834	T4747	T4745	pobj	individuals,among
R2835	T4748	T4747	amod	non-BC,individuals
R2836	T4749	T4731	cc	but,correlated
R2837	T4750	T4751	neg	not,correlated
R2838	T4751	T4731	conj	correlated,correlated
R2839	T4752	T4751	prep	in,correlated
R2840	T4753	T4754	compound	BC,individuals
R2841	T4754	T4752	pobj	individuals,in
R2842	T4755	T4722	punct	.,expected
R2843	T4757	T4758	advmod	Thus,are
R2844	T4759	T4758	punct	", ",are
R2845	T4760	T4758	expl	there,are
R2846	T4761	T4762	amod	multiple,explanations
R2847	T4762	T4758	attr	explanations,are
R2848	T4763	T4762	amod	possible,explanations
R2849	T4764	T4762	prep	for,explanations
R2850	T4765	T4766	det	the,findings
R2851	T4766	T4764	pobj	findings,for
R2852	T4767	T4766	amod	observed,findings
R2853	T4768	T4758	punct	.,are
R2854	T4770	T4771	advmod	However,conclude
R2855	T4772	T4771	punct	", ",conclude
R2856	T4773	T4771	prep	based,conclude
R2857	T4774	T4773	prep	on,based
R2858	T4775	T4776	det	the,preponderance
R2859	T4776	T4774	pobj	preponderance,on
R2860	T4777	T4776	prep	of,preponderance
R2861	T4778	T4777	pobj	data,of
R2862	T4779	T4780	advmod	thus,far
R2863	T4780	T4781	advmod	far,available
R2864	T4781	T4778	amod	available,data
R2865	T4782	T4771	punct	", ",conclude
R2866	T4783	T4771	nsubj	we,conclude
R2867	T4784	T4785	mark	that,is
R2868	T4785	T4771	advcl	is,conclude
R2869	T4786	T4785	nsubj	CEBPG,is
R2870	T4787	T4785	acomp	responsible,is
R2871	T4788	T4787	prep	for,responsible
R2872	T4789	T4790	amod	optimal,regulation
R2873	T4790	T4788	pobj	regulation,for
R2874	T4791	T4790	amod	transcriptional,regulation
R2875	T4792	T4790	prep	of,regulation
R2876	T4793	T4794	amod	key,genes
R2877	T4794	T4792	pobj	genes,of
R2878	T4795	T4794	amod	antioxidant,genes
R2879	T4796	T4795	cc	or,antioxidant
R2880	T4797	T4798	compound	DNA,repair
R2881	T4798	T4795	conj	repair,antioxidant
R2882	T4799	T4785	prep	in,is
R2883	T4800	T4799	pobj	NBEC,in
R2884	T4801	T4785	cc	and,is
R2885	T4802	T4803	mark	that,is
R2886	T4803	T4785	conj	is,is
R2887	T4804	T4803	expl	there,is
R2888	T4805	T4806	amod	inter-individual,variation
R2889	T4806	T4803	attr	variation,is
R2890	T4807	T4803	prep	in,is
R2891	T4808	T4809	det	the,regulation
R2892	T4809	T4807	pobj	regulation,in
R2893	T4810	T4809	prep	of,regulation
R2894	T4811	T4810	pobj	each,of
R2895	T4812	T4811	prep	of,each
R2896	T4813	T4814	det	these,genes
R2897	T4814	T4812	pobj	genes,of
R2898	T4815	T4809	prep	by,regulation
R2899	T4816	T4815	pobj	CEBPG,by
R2900	T4817	T4771	punct	.,conclude
R2901	T4819	T4820	mark	If,is
R2903	T4821	T4822	det	this,conclusion
R2904	T4822	T4820	nsubj	conclusion,is
R2905	T4824	T4820	acomp	correct,is
R2906	T4825	T4823	punct	", ",be
R2907	T4826	T4827	det	the,individuals
R2908	T4827	T4823	nsubj	individuals,be
R2909	T4828	T4827	prep	at,individuals
R2910	T4829	T4830	amod	greatest,risk
R2911	T4830	T4828	pobj	risk,at
R2912	T4831	T4830	prep	for,risk
R2913	T4832	T4831	pobj	BC,for
R2914	T4833	T4823	aux	will,be
R2915	T4834	T4823	attr	those,be
R2916	T4835	T4834	prep	with,those
R2917	T4836	T4837	det	the,history
R2918	T4837	T4835	pobj	history,with
R2919	T4838	T4839	advmod	most,extreme
R2920	T4839	T4837	amod	extreme,history
R2921	T4840	T4837	compound	smoking,history
R2922	T4841	T4837	acl	combined,history
R2923	T4842	T4841	prep	with,combined
R2924	T4843	T4844	amod	sub-optimal,regulation
R2925	T4844	T4842	pobj	regulation,with
R2926	T4845	T4844	prep	of,regulation
R2927	T4846	T4847	det	the,number
R2928	T4847	T4845	pobj	number,of
R2929	T4848	T4847	amod	largest,number
R2930	T4849	T4847	prep	of,number
R2931	T4850	T4851	nmod	antioxidant,genes
R2932	T4851	T4849	pobj	genes,of
R2933	T4852	T4850	cc	and,antioxidant
R2934	T4853	T4854	compound	DNA,repair
R2935	T4854	T4850	conj	repair,antioxidant
R2936	T4855	T4823	punct	.,be
R2937	T4857	T4858	nsubj	This,leads
R2938	T4859	T4858	punct	", ",leads
R2939	T4860	T4858	prep	in,leads
R2940	T4861	T4860	pobj	turn,in
R2941	T4862	T4858	punct	", ",leads
R2942	T4863	T4858	prep	to,leads
R2943	T4864	T4865	amod	increased,representation
R2944	T4865	T4863	pobj	representation,to
R2945	T4866	T4865	prep	among,representation
R2946	T4867	T4868	compound	BC,individuals
R2947	T4868	T4866	pobj	individuals,among
R2948	T4869	T4865	prep	of,representation
R2949	T4870	T4869	pobj	individuals,of
R2950	T4871	T4870	prep	with,individuals
R2951	T4872	T4871	pobj	lack,with
R2952	T4873	T4872	prep	of,lack
R2953	T4874	T4873	pobj	correlation,of
R2954	T4875	T4874	prep	between,correlation
R2955	T4876	T4875	pobj	CEBPG,between
R2956	T4877	T4876	cc	and,CEBPG
R2957	T4878	T4876	conj	each,CEBPG
R2958	T4879	T4878	prep	of,each
R2959	T4880	T4881	det	the,genes
R2960	T4881	T4879	pobj	genes,of
R2961	T4882	T4881	amod	affected,genes
R2962	T4883	T4881	nmod	antioxidant,genes
R2963	T4884	T4883	cc	and,antioxidant
R2964	T4885	T4884	punct	/,and
R2965	T4886	T4884	cc	or,and
R2966	T4887	T4888	compound	DNA,repair
R2967	T4888	T4883	conj	repair,antioxidant
R2968	T4889	T4858	punct	.,leads
R2969	T4891	T4892	nsubj	CEBPG,is
R2970	T4893	T4894	det	a,factor
R2971	T4894	T4892	attr	factor,is
R2972	T4895	T4894	amod	truncated,factor
R2973	T4896	T4894	compound	CEBP,factor
R2974	T4897	T4894	compound	transcription,factor
R2975	T4898	T4899	punct	[,19
R2976	T4899	T4892	parataxis	19,is
R2977	T4900	T4899	punct	],19
R2978	T4901	T4892	cc	and,is
R2979	T4902	T4892	conj	possesses,is
R2980	T4903	T4904	det	the,sequences
R2981	T4904	T4902	dobj	sequences,possesses
R2982	T4905	T4904	amod	necessary,sequences
R2983	T4906	T4905	prep	for,necessary
R2984	T4907	T4908	compound	DNA,binding
R2985	T4908	T4906	pobj	binding,for
R2986	T4909	T4908	cc	and,binding
R2987	T4910	T4911	compound	heterodimer,formation
R2988	T4911	T4908	conj	formation,binding
R2989	T4912	T4892	punct	", ",is
R2990	T4913	T4892	cc	but,is
R2991	T4914	T4892	conj	lacks,is
R2992	T4915	T4916	det	the,sequences
R2993	T4916	T4914	dobj	sequences,lacks
R2994	T4917	T4916	amod	necessary,sequences
R2995	T4918	T4917	prep	for,necessary
R2996	T4919	T4918	pobj	transactivation,for
R2997	T4920	T4921	punct	[,20
R2998	T4921	T4914	parataxis	20,lacks
R2999	T4922	T4921	punct	],20
R3000	T4923	T4892	punct	.,is
R3001	T4925	T4926	nsubj	CEBPG,forms
R3002	T4927	T4926	dobj	heterodimers,forms
R3003	T4928	T4926	prep	with,forms
R3004	T4929	T4930	amod	other,members
R3006	T4931	T4930	compound	CEBP,members
R3007	T4932	T4930	compound	family,members
R3008	T4933	T4926	cc	and,forms
R3009	T4934	T4935	prep	in,leads
R3010	T4935	T4926	conj	leads,forms
R3011	T4936	T4937	amod	other,tissues
R3012	T4937	T4934	pobj	tissues,in
R3013	T4938	T4935	nsubj	this,leads
R3014	T4939	T4935	prep	to,leads
R3015	T4940	T4941	amod	increased,transcription
R3016	T4941	T4939	pobj	transcription,to
R3017	T4942	T4943	punct	[,21
R3018	T4943	T4940	parataxis	21,increased
R3019	T4944	T4943	punct	],21
R3020	T4945	T4940	cc	or,increased
R3021	T4946	T4940	conj	decreased,increased
R3022	T4947	T4948	punct	[,20
R3023	T4948	T4946	parataxis	20,decreased
R3024	T4949	T4948	punct	],20
R3025	T4950	T4941	prep	of,transcription
R3026	T4951	T4952	det	the,gene
R3027	T4952	T4950	pobj	gene,of
R3028	T4953	T4952	amod	regulated,gene
R3029	T4954	T4935	punct	.,leads
R3030	T4956	T4957	nsubjpass	CEBPG,known
R3031	T4958	T4957	auxpass	is,known
R3032	T4959	T4960	aux	to,have
R3033	T4960	T4957	xcomp	have,known
R3034	T4961	T4962	amod	stimulatory,effect
R3035	T4962	T4960	dobj	effect,have
R3036	T4963	T4962	prep	on,effect
R3037	T4964	T4965	det	the,promoters
R3038	T4965	T4963	pobj	promoters,on
R3039	T4966	T4965	nmod	IL,promoters
R3040	T4967	T4966	punct	-,IL
R3041	T4968	T4966	nummod	6,IL
R3042	T4969	T4966	cc	and,IL
R3043	T4970	T4966	conj	IL,IL
R3044	T4971	T4970	punct	-,IL
R3045	T4972	T4970	nummod	8,IL
R3046	T4973	T4962	prep	in,effect
R3047	T4974	T4975	compound	B,cell
R3048	T4975	T4976	compound	cell,lines
R3049	T4976	T4973	pobj	lines,in
R3050	T4977	T4978	punct	[,21
R3051	T4978	T4957	parataxis	21,known
R3052	T4979	T4978	punct	],21
R3053	T4980	T4957	punct	", ",known
R3054	T4981	T4957	cc	and,known
R3055	T4982	T4983	aux	can,act
R3056	T4983	T4957	conj	act,known
R3057	T4984	T4983	advmod	also,act
R3058	T4985	T4983	prep	as,act
R3059	T4986	T4987	det	a,regulator
R3061	T4988	T4987	amod	dominant,regulator
R3062	T4989	T4987	amod	negative,regulator
R3063	T4990	T4987	prep	of,regulator
R3064	T4991	T4990	pobj	CEBPA,of
R3065	T4992	T4991	cc	and,CEBPA
R3066	T4993	T4991	conj	CEBPB,CEBPA
R3067	T4994	T4983	prep	in,act
R3068	T4995	T4996	nmod	fibroblast,lines
R3069	T4996	T4994	pobj	lines,in
R3070	T4997	T4995	cc	and,fibroblast
R3071	T4998	T4995	conj	B,fibroblast
R3072	T4999	T4996	compound	cell,lines
R3073	T5000	T5001	punct	[,20
R3074	T5001	T4983	parataxis	20,act
R3075	T5002	T5001	punct	],20
R3076	T5003	T4957	punct	.,known
R3077	T5005	T5006	det	The,data
R3078	T5006	T5007	nsubj	data,support
R3079	T5008	T5006	prep	from,data
R3080	T5009	T5010	compound	CEBPG,mice
R3081	T5010	T5008	pobj	mice,from
R3082	T5011	T5010	compound	knockout,mice
R3083	T5012	T5013	det	a,role
R3084	T5013	T5007	dobj	role,support
R3085	T5014	T5013	prep	for,role
R3086	T5015	T5014	pobj	CEBPG,for
R3087	T5016	T5013	prep	in,role
R3088	T5017	T5016	pcomp	protecting,in
R3089	T5018	T5017	dobj	lungs,protecting
R3090	T5019	T5017	prep	from,protecting
R3091	T5020	T5021	compound	oxidant,damage
R3092	T5021	T5019	pobj	damage,from
R3093	T5022	T5007	punct	.,support
R3094	T5024	T5025	nmod	CEBPG,knockout
R3095	T5068	T5054	cc	and,associated
R3097	T5069	T5070	expl	there,is
R3098	T5026	T5024	punct	-,CEBPG
R3099	T5070	T5054	conj	is,associated
R3100	T5027	T5024	punct	/,CEBPG
R3101	T5071	T5072	det	a,correlation
R3102	T5072	T5070	attr	correlation,is
R3103	T5073	T5072	amod	strong,correlation
R3104	T5028	T5024	punct	-,CEBPG
R3105	T5074	T5072	prep	between,correlation
R3106	T5075	T5074	pobj	risk,between
R3107	T5029	T5030	nsubj	mice,are
R3108	T5076	T5075	prep	for,risk
R3109	T5077	T5076	pobj	emphysema,for
R3110	T5078	T5075	cc	and,risk
R3111	T5031	T5030	acomp	healthy,are
R3112	T5079	T5075	conj	risk,risk
R3113	T5080	T5079	prep	for,risk
R3114	T5081	T5080	pobj	BC,for
R3115	T5082	T5054	punct	.,associated
R3116	T5032	T5030	prep	at,are
R3117	T5084	T5085	advmod	However,be
R3118	T5033	T5032	pobj	birth,at
R3119	T5086	T5085	punct	", ",be
R3120	T5087	T5085	nsubj	it,be
R3121	T5034	T5030	cc	but,are
R3122	T5088	T5085	aux	will,be
R3123	T5089	T5085	acomp	important,be
R3124	T5035	T5030	conj	begin,are
R3125	T5090	T5091	aux	to,obtain
R3126	T5091	T5085	xcomp	obtain,be
R3127	T5092	T5093	amod	direct,evidence
R3128	T5036	T5037	aux	to,die
R3129	T5093	T5091	dobj	evidence,obtain
R3130	T5094	T5093	amod	experimental,evidence
R3131	T5095	T5093	prep	in,evidence
R3132	T5096	T5095	pobj	NBECs,in
R3133	T5097	T5093	prep	for,evidence
R3134	T5098	T5099	det	the,role
R3135	T5037	T5035	xcomp	die,begin
R3136	T5099	T5097	pobj	role,for
R3137	T5038	T5035	prep	within,begin
R3138	T5100	T5099	prep	of,role
R3139	T5101	T5100	pobj	CEBPG,of
R3140	T5102	T5099	prep	in,role
R3141	T5103	T5102	pcomp	regulating,in
R3142	T5104	T5105	det	the,genes
R3143	T5039	T5040	nummod	24,hours
R3144	T5105	T5103	dobj	genes,regulating
R3145	T5106	T5105	nmod	antioxidant,genes
R3146	T5107	T5106	cc	and,antioxidant
R3147	T5040	T5038	pobj	hours,within
R3148	T5108	T5109	compound	DNA,repair
R3149	T5109	T5106	conj	repair,antioxidant
R3150	T5110	T5105	acl	included,genes
R3151	T5041	T5030	punct	", ",are
R3152	T5111	T5110	prep	in,included
R3153	T5112	T5113	det	this,study
R3154	T5113	T5111	pobj	study,in
R3155	T5042	T5030	cc	and,are
R3156	T5114	T5085	punct	.,be
R3157	T5043	T5044	amod	histological,examination
R3158	T5116	T5117	nsubjpass	Correlation,associated
R3159	T5118	T5116	prep	between,Correlation
R3160	T5044	T5045	nsubj	examination,reveals
R3161	T5119	T5118	pobj	CEBPG,between
R3162	T5120	T5119	cc	and,CEBPG
R3163	T5121	T5122	compound	target,gene
R3164	T5045	T5030	conj	reveals,are
R3165	T5122	T5123	compound	gene,levels
R3166	T5123	T5119	conj	levels,CEBPG
R3167	T5124	T5123	compound	transcript,levels
R3168	T5046	T5047	amod	emphysematous,lungs
R3169	T5125	T5117	aux	may,associated
R3170	T5126	T5117	neg	not,associated
R3171	T5127	T5117	auxpass	be,associated
R3172	T5047	T5045	dobj	lungs,reveals
R3173	T5048	T5049	punct	[,22
R3174	T5128	T5117	prep	with,associated
R3175	T5129	T5128	pobj	correlation,with
R3176	T5130	T5129	prep	at,correlation
R3177	T5049	T5045	parataxis	22,reveals
R3178	T5131	T5132	det	the,level
R3179	T5132	T5130	pobj	level,at
R3180	T5050	T5049	punct	],22
R3181	T5133	T5132	compound	protein,level
R3182	T5134	T5117	punct	.,associated
R3183	T5051	T5045	punct	.,reveals
R3184	T5136	T5137	prep	In,was
R3185	T5138	T5139	det	this,study
R3186	T5139	T5136	pobj	study,In
R3187	T5140	T5137	punct	", ",was
R3188	T5053	T5054	prep	In,associated
R3189	T5141	T5142	compound	E2F1,correlation
R3190	T5142	T5137	nsubj	correlation,was
R3191	T5143	T5142	prep	with,correlation
R3192	T5144	T5145	nmod	DNA,repair
R3193	T5055	T5053	pobj	humans,In
R3194	T5145	T5146	nmod	repair,genes
R3195	T5146	T5143	pobj	genes,with
R3196	T5147	T5145	cc	and,repair
R3197	T5148	T5145	conj	antioxidant,repair
R3198	T5056	T5054	punct	", ",associated
R3199	T5149	T5137	acomp	less,was
R3200	T5150	T5149	prep	than,less
R3201	T5151	T5152	det	the,correlation
R3202	T5057	T5054	nsubjpass	risk,associated
R3203	T5152	T5150	pobj	correlation,than
R3204	T5153	T5152	acl	observed,correlation
R3205	T5154	T5153	prep	with,observed
R3206	T5058	T5057	prep	for,risk
R3207	T5155	T5154	pobj	CEBPG,with
R3208	T5156	T5137	punct	", ",was
R3209	T5157	T5137	cc	and,was
R3210	T5059	T5058	pobj	emphysema,for
R3211	T5158	T5159	det	the,correlation
R3212	T5159	T5161	nsubjpass	correlation,observed
R3213	T5160	T5159	compound	E2F1,correlation
R3214	T5060	T5054	auxpass	is,associated
R3215	T5161	T5137	conj	observed,was
R3216	T5162	T5161	auxpass	was,observed
R3217	T5163	T5161	prep	in,observed
R3218	T5061	T5054	prep	with,associated
R3219	T5164	T5165	preconj	both,individuals
R3220	T5165	T5163	pobj	individuals,in
R3221	T5166	T5165	amod	non-BC,individuals
R3222	T5062	T5063	compound	antioxidant,capacity
R3223	T5167	T5168	advmod	as,as
R3224	T5168	T5165	cc	as,individuals
R3225	T5169	T5168	advmod	well,as
R3226	T5063	T5061	pobj	capacity,with
R3227	T5170	T5171	compound	BC,individuals
R3228	T5171	T5165	conj	individuals,individuals
R3229	T5172	T5161	punct	.,observed
R3230	T5064	T5065	punct	[,23
R3231	T5174	T5175	det	The,correlation
R3232	T5065	T5054	parataxis	23,associated
R3233	T5066	T5065	punct	],23
R3234	T5067	T5054	punct	", ",associated
R3235	T5175	T5177	nsubj	correlation,suggests
R3236	T5176	T5175	amod	maintained,correlation
R3237	T5178	T5175	prep	of,correlation
R3238	T5179	T5178	pobj	E2F1,of
R3239	T5180	T5175	prep	with,correlation
R3240	T5281	T5282	nsubj	assessment,been
R3241	T5181	T5182	nmod	DNA,repair
R3242	T5182	T5183	nmod	repair,genes
R3243	T5183	T5180	pobj	genes,with
R3244	T5184	T5182	cc	and,repair
R3245	T5283	T5281	prep	of,assessment
R3246	T5185	T5182	conj	antioxidant,repair
R3247	T5186	T5175	prep	in,correlation
R3248	T5187	T5188	compound	BC,individuals
R3249	T5188	T5186	pobj	individuals,in
R3250	T5189	T5190	mark	that,controlled
R3251	T5190	T5177	ccomp	controlled,suggests
R3252	T5191	T5192	det	this,function
R3253	T5284	T5285	det	the,correlation
R3254	T5192	T5190	nsubjpass	function,controlled
R3255	T5193	T5190	auxpass	is,controlled
R3256	T5194	T5195	advmod	more,tightly
R3257	T5285	T5283	pobj	correlation,of
R3258	T5195	T5190	advmod	tightly,controlled
R3259	T5196	T5190	prep	in,controlled
R3260	T5197	T5198	det	the,population
R3261	T5286	T5285	prep	between,correlation
R3262	T5198	T5196	pobj	population,in
R3263	T5199	T5190	cc	and,controlled
R3264	T5200	T5201	aux	does,play
R3265	T5201	T5190	conj	play,controlled
R3266	T5287	T5288	det	a,variation
R3267	T5202	T5201	neg	not,play
R3268	T5203	T5204	det	a,role
R3269	T5204	T5201	dobj	role,play
R3270	T5288	T5286	pobj	variation,between
R3271	T5205	T5201	prep	in,play
R3272	T5206	T5205	pobj	determination,in
R3273	T5207	T5206	prep	of,determination
R3274	T5208	T5207	pobj	risk,of
R3275	T5289	T5288	amod	particular,variation
R3276	T5209	T5208	prep	for,risk
R3277	T5210	T5209	pobj	BC,for
R3278	T5290	T5288	prep	in,variation
R3279	T5211	T5177	punct	.,suggests
R3280	T5213	T5214	nsubjpass	E2F1,reported
R3281	T5291	T5292	compound	DNA,sequence
R3282	T5292	T5290	pobj	sequence,in
R3283	T5215	T5214	aux	has,reported
R3284	T5216	T5214	advmod	previously,reported
R3285	T5293	T5288	punct	", ",variation
R3286	T5217	T5214	auxpass	been,reported
R3287	T5218	T5219	aux	to,regulate
R3288	T5219	T5214	xcomp	regulate,reported
R3289	T5220	T5219	dobj	transcription,regulate
R3290	T5221	T5220	prep	of,transcription
R3291	T5294	T5288	cc	or,variation
R3292	T5222	T5223	compound	DNA,repair
R3293	T5223	T5224	compound	repair,genes
R3294	T5224	T5221	pobj	genes,of
R3295	T5295	T5288	conj	polymorphism,variation
R3296	T5225	T5224	compound	enzyme,genes
R3297	T5226	T5219	prep	in,regulate
R3298	T5227	T5228	amod	other,types
R3299	T5296	T5288	punct	", ",variation
R3300	T5228	T5226	pobj	types,in
R3301	T5229	T5228	compound	cell,types
R3302	T5230	T5228	punct	", ",types
R3303	T5231	T5228	prep	including,types
R3304	T5297	T5288	cc	and,variation
R3305	T5232	T5233	amod	primary,fibroblasts
R3306	T5233	T5231	pobj	fibroblasts,including
R3307	T5234	T5233	amod	human,fibroblasts
R3308	T5298	T5288	conj	risk,variation
R3309	T5235	T5233	cc	and,fibroblasts
R3310	T5236	T5237	nmod	mouse,cells
R3311	T5237	T5233	conj	cells,fibroblasts
R3312	T5238	T5237	amod	epidermal,cells
R3313	T5299	T5298	prep	for,risk
R3314	T5239	T5240	punct	[,25
R3315	T5240	T5214	parataxis	25,reported
R3316	T5241	T5240	nummod	24,25
R3317	T5300	T5299	pobj	BC,for
R3318	T5242	T5240	punct	",",25
R3319	T5243	T5240	punct	],25
R3320	T5244	T5214	punct	.,reported
R3321	T5301	T5282	aux	has,been
R3322	T5246	T5247	advmod	Clearly,have
R3323	T5302	T5303	det	a,paradigm
R3324	T5248	T5247	nsubj	this,have
R3325	T5249	T5247	aux	would,have
R3326	T5250	T5251	compound	survival,value
R3327	T5251	T5247	dobj	value,have
R3328	T5303	T5282	attr	paradigm,been
R3329	T5252	T5253	mark	since,provides
R3330	T5253	T5247	advcl	provides,have
R3331	T5254	T5255	nmod	DNA,repair
R3332	T5304	T5303	amod	dominant,paradigm
R3333	T5255	T5256	nmod	repair,gene
R3334	T5256	T5257	nmod	gene,regulation
R3335	T5257	T5253	nsubj	regulation,provides
R3336	T5305	T5282	prep	for,been
R3337	T5258	T5257	amod	up,regulation
R3338	T5259	T5257	punct	-,regulation
R3339	T5260	T5257	prep	in,regulation
R3340	T5261	T5260	pobj	response,in
R3341	T5262	T5261	prep	to,response
R3342	T5263	T5262	pobj	E2F1,to
R3343	T5306	T5307	amod	many,years
R3344	T5264	T5265	amod	additional,repair
R3345	T5265	T5253	dobj	repair,provides
R3346	T5266	T5265	compound	DNA,repair
R3347	T5307	T5305	pobj	years,for
R3348	T5267	T5268	advmod	when,replicating
R3349	T5268	T5253	advcl	replicating,provides
R3350	T5269	T5270	det	the,DNA
R3351	T5270	T5268	nsubj	DNA,replicating
R3352	T5308	T5282	punct	.,been
R3353	T5271	T5268	aux	is,replicating
R3354	T5272	T5268	cc	and,replicating
R3355	T5273	T5268	conj	is,replicating
R3356	T5310	T5311	advmod	Thus,far
R3357	T5274	T5275	advmod	particularly,vulnerable
R3358	T5275	T5273	acomp	vulnerable,is
R3359	T5276	T5275	prep	to,vulnerable
R3360	T5277	T5276	pobj	damage,to
R3362	T5278	T5247	punct	.,have
R3363	T5280	T5281	amod	Epidemiologic,assessment
R3364	T5313	T5312	punct	", ",met
R3365	T5314	T5315	det	these,efforts
R3366	T5315	T5312	nsubj	efforts,met
R3367	T5387	T5385	cc	and,empiric
R3368	T5316	T5312	aux	have,met
R3369	T5388	T5387	neg	not,and
R3370	T5389	T5385	conj	based,empiric
R3371	T5317	T5312	prep	with,met
R3372	T5390	T5389	prep	on,based
R3373	T5391	T5392	amod	known,properties
R3374	T5318	T5319	amod	scant,success
R3375	T5392	T5390	pobj	properties,on
R3376	T5393	T5392	amod	functional,properties
R3377	T5394	T5351	punct	.,is
R3378	T5319	T5317	pobj	success,with
R3379	T5396	T5397	nsubj	These,are
R3380	T5320	T5321	punct	[,26
R3381	T5398	T5397	attr	problems,are
R3382	T5399	T5400	mark	because,contribute
R3383	T5321	T5312	parataxis	26,met
R3384	T5400	T5397	advcl	contribute,are
R3385	T5322	T5321	punct	],26
R3386	T5401	T5402	amod	multiple,polymorphisms
R3387	T5323	T5312	punct	.,met
R3388	T5402	T5400	nsubj	polymorphisms,contribute
R3389	T5403	T5402	amod	infrequent,polymorphisms
R3390	T5325	T5326	det	A,limitation
R3391	T5404	T5402	prep	at,polymorphisms
R3392	T5405	T5406	amod	different,sites
R3393	T5406	T5404	pobj	sites,at
R3394	T5407	T5400	aux	may,contribute
R3395	T5408	T5400	advmod	all,contribute
R3396	T5409	T5400	prep	to,contribute
R3397	T5410	T5409	pobj	risk,to
R3398	T5411	T5400	cc	and,contribute
R3399	T5326	T5328	nsubj	limitation,is
R3400	T5412	T5413	mark	unless,identified
R3401	T5413	T5419	advcl	identified,require
R3402	T5414	T5415	det	the,polymorphisms
R3403	T5327	T5326	amod	common,limitation
R3404	T5415	T5413	nsubjpass	polymorphisms,identified
R3405	T5329	T5326	prep	in,limitation
R3406	T5416	T5415	amod	key,polymorphisms
R3407	T5417	T5413	aux	can,identified
R3408	T5418	T5413	auxpass	be,identified
R3409	T5419	T5400	conj	require,contribute
R3410	T5420	T5413	prep	through,identified
R3411	T5330	T5329	pobj	design,in
R3412	T5421	T5422	det	a,test
R3413	T5422	T5420	pobj	test,through
R3414	T5423	T5422	amod	functional,test
R3415	T5331	T5330	prep	of,design
R3416	T5424	T5419	punct	", ",require
R3417	T5425	T5426	det	a,assessment
R3418	T5426	T5419	nsubj	assessment,require
R3419	T5332	T5333	amod	such,studies
R3420	T5427	T5428	advmod	statistically,valid
R3421	T5428	T5426	amod	valid,assessment
R3422	T5429	T5419	aux	would,require
R3423	T5333	T5331	pobj	studies,of
R3424	T5430	T5431	advmod	much,larger
R3425	T5431	T5432	amod	larger,populations
R3426	T5432	T5419	dobj	populations,require
R3427	T5433	T5432	compound	study,populations
R3428	T5334	T5335	mark	that,involve
R3429	T5434	T5435	punct	[,27
R3430	T5435	T5397	parataxis	27,are
R3431	T5436	T5435	punct	],27
R3432	T5335	T5328	ccomp	involve,is
R3433	T5437	T5397	punct	.,are
R3434	T5336	T5335	nsubj	they,involve
R3435	T5439	T5440	det	The,findings
R3436	T5440	T5441	nsubj	findings,support
R3437	T5337	T5335	dobj	assessment,involve
R3438	T5442	T5440	prep	of,findings
R3439	T5443	T5444	det	this,study
R3440	T5444	T5442	pobj	study,of
R3441	T5338	T5337	prep	of,assessment
R3442	T5445	T5446	det	a,approach
R3443	T5446	T5441	dobj	approach,support
R3444	T5447	T5446	amod	novel,approach
R3445	T5448	T5446	prep	to,approach
R3446	T5449	T5448	pcomp	identifying,to
R3447	T5450	T5451	advmod	clinically,useful
R3448	T5339	T5340	det	a,polymorphism
R3449	T5451	T5452	amod	useful,biomarkers
R3450	T5452	T5449	dobj	biomarkers,identifying
R3451	T5453	T5441	punct	.,support
R3452	T5340	T5338	pobj	polymorphism,of
R3453	T5455	T5456	prep	According,results
R3454	T5341	T5340	amod	single,polymorphism
R3455	T5342	T5340	cc	or,polymorphism
R3456	T5457	T5455	prep	to,According
R3457	T5343	T5344	advmod	occasionally,polymorphisms
R3458	T5458	T5459	det	the,paradigm
R3459	T5344	T5340	conj	polymorphisms,polymorphism
R3460	T5459	T5457	pobj	paradigm,to
R3461	T5460	T5459	acl	used,paradigm
R3462	T5461	T5460	prep	in,used
R3463	T5462	T5463	det	this,study
R3464	T5345	T5344	punct	", ",polymorphisms
R3465	T5463	T5461	pobj	study,in
R3466	T5464	T5456	punct	", ",results
R3467	T5465	T5456	meta	a,results
R3468	T5346	T5344	det	a,polymorphisms
R3469	T5466	T5465	punct	),a
R3470	T5467	T5468	det	a,phenotype
R3471	T5468	T5456	nsubj	phenotype,results
R3472	T5347	T5344	amod	few,polymorphisms
R3473	T5469	T5468	amod	normal,phenotype
R3474	T5470	T5456	prep	from,results
R3475	T5471	T5472	amod	regulated,transcription
R3476	T5348	T5328	punct	.,is
R3477	T5472	T5470	pobj	transcription,from
R3478	T5473	T5472	prep	of,transcription
R3479	T5350	T5351	advmod	Further,is
R3480	T5474	T5475	det	a,group
R3481	T5352	T5351	punct	", ",is
R3482	T5475	T5473	pobj	group,of
R3483	T5476	T5475	prep	of,group
R3484	T5477	T5476	pobj	genes,of
R3485	T5478	T5472	prep	by,transcription
R3486	T5353	T5354	mark	although,resides
R3487	T5479	T5480	nummod	one,factors
R3488	T5480	T5478	pobj	factors,by
R3489	T5354	T5351	advcl	resides,is
R3490	T5481	T5479	cc	or,one
R3491	T5482	T5479	conj	more,one
R3492	T5483	T5480	compound	transcription,factors
R3493	T5484	T5456	punct	", ",results
R3494	T5355	T5356	det	the,polymorphism
R3495	T5485	T5486	meta	b,results
R3496	T5486	T5456	conj	results,results
R3497	T5487	T5485	punct	),b
R3498	T5488	T5489	det	the,phenotype
R3499	T5489	T5486	nsubj	phenotype,results
R3500	T5490	T5489	amod	corresponding,phenotype
R3501	T5356	T5354	nsubj	polymorphism,resides
R3502	T5491	T5492	npadvmod	risk,conferring
R3503	T5492	T5489	amod	conferring,phenotype
R3504	T5357	T5356	acl	assessed,polymorphism
R3505	T5358	T5354	advmod	typically,resides
R3506	T5359	T5354	prep	within,resides
R3507	T5360	T5361	det	a,gene
R3508	T5493	T5492	punct	-,conferring
R3509	T5494	T5492	cc	or,conferring
R3510	T5361	T5359	pobj	gene,within
R3511	T5495	T5492	conj	disease,conferring
R3512	T5496	T5486	prep	from,results
R3513	T5362	T5361	acl	known,gene
R3514	T5497	T5498	amod	sub-optimal,interaction
R3515	T5498	T5496	pobj	interaction,from
R3516	T5499	T5498	prep	among,interaction
R3517	T5363	T5364	aux	to,protect
R3518	T5500	T5501	det	those,genes
R3519	T5501	T5499	pobj	genes,among
R3520	T5502	T5501	amod	same,genes
R3521	T5364	T5362	xcomp	protect,known
R3522	T5503	T5486	punct	", ",results
R3523	T5504	T5486	cc	and,results
R3524	T5365	T5366	amod	bronchial,epithelium
R3525	T5505	T5506	meta	c,is
R3526	T5506	T5486	conj	is,results
R3527	T5507	T5505	punct	),c
R3528	T5508	T5509	det	each,phenotype
R3529	T5366	T5364	dobj	epithelium,protect
R3530	T5509	T5506	nsubj	phenotype,is
R3531	T5510	T5506	acomp	identifiable,is
R3532	T5367	T5364	prep	from,protect
R3533	T5511	T5510	cc	and,identifiable
R3534	T5512	T5510	conj	distinguishable,identifiable
R3535	T5513	T5512	prep	through,distinguishable
R3536	T5514	T5515	advmod	virtually,multiplexed
R3537	T5368	T5367	pobj	carcinogens,from
R3538	T5515	T5517	amod	multiplexed,analysis
R3539	T5516	T5515	punct	-,multiplexed
R3540	T5517	T5513	pobj	analysis,through
R3541	T5369	T5368	punct	", ",carcinogens
R3542	T5518	T5519	compound	transcript,abundance
R3543	T5519	T5517	compound	abundance,analysis
R3544	T5370	T5368	conj	oxidants,carcinogens
R3545	T5520	T5456	punct	.,results
R3546	T5522	T5523	det	The,data
R3547	T5371	T5370	punct	", ",oxidants
R3548	T5523	T5524	nsubj	data,support
R3549	T5525	T5523	acl	presented,data
R3550	T5526	T5525	advmod	here,presented
R3551	T5527	T5528	det	the,utility
R3552	T5372	T5370	cc	or,oxidants
R3553	T5528	T5524	dobj	utility,support
R3554	T5529	T5528	prep	of,utility
R3555	T5530	T5531	det	this,paradigm
R3556	T5531	T5529	pobj	paradigm,of
R3557	T5373	T5374	compound	DNA,damage
R3558	T5532	T5528	prep	in,utility
R3559	T5533	T5532	pcomp	identifying,in
R3560	T5374	T5370	conj	damage,oxidants
R3561	T5534	T5533	dobj	genes,identifying
R3562	T5535	T5534	acl	associated,genes
R3563	T5536	T5535	prep	with,associated
R3564	T5375	T5351	punct	", ",is
R3565	T5537	T5536	pobj	risk,with
R3566	T5538	T5537	prep	for,risk
R3567	T5376	T5377	det	the,selection
R3568	T5539	T5538	pobj	BC,for
R3569	T5540	T5524	punct	.,support
R3570	T5377	T5351	nsubj	selection,is
R3571	T5542	T5543	det	The,step
R3572	T5543	T5545	nsubj	step,be
R3573	T5378	T5377	prep	of,selection
R3574	T5544	T5543	amod	next,step
R3575	T5546	T5545	aux	will,be
R3576	T5379	T5380	det	the,polymorphism
R3577	T5547	T5548	aux	to,identify
R3578	T5548	T5545	xcomp	identify,be
R3579	T5549	T5548	dobj	polymorphisms,identify
R3580	T5380	T5378	pobj	polymorphism,of
R3581	T5550	T5551	dep	that,affect
R3582	T5551	T5549	relcl	affect,polymorphisms
R3583	T5552	T5551	dobj	regulation,affect
R3584	T5381	T5380	amod	particular,polymorphism
R3585	T5553	T5552	prep	of,regulation
R3586	T5554	T5553	pobj	XRCC1,of
R3587	T5555	T5554	punct	", ",XRCC1
R3588	T5382	T5377	prep	for,selection
R3589	T5556	T5554	conj	ERCC5,XRCC1
R3590	T5557	T5556	punct	", ",ERCC5
R3591	T5558	T5556	conj	GSTP1,ERCC5
R3592	T5383	T5382	pobj	study,for
R3593	T5384	T5385	advmod	largely,empiric
R3597	T5385	T5351	acomp	empiric,is
R3598	T5562	T5560	cc	and,SOD1
R3599	T5563	T5560	conj	GPX1,SOD1
R3600	T5564	T5552	prep	by,regulation
R3601	T5565	T5564	pobj	CEBPG,by
R3602	T5566	T5545	punct	.,be
R3603	T5386	T5385	punct	", ",empiric
R3604	T5568	T5569	amod	Such,polymorphisms
R3605	T5599	T5600	dep	that,affect
R3606	T5569	T5570	nsubj	polymorphisms,yield
R3607	T5571	T5570	aux	should,yield
R3608	T5572	T5570	dobj	biomarkers,yield
R3609	T5600	T5598	relcl	affect,those
R3610	T5573	T5572	amod	suitable,biomarkers
R3611	T5574	T5573	prep	for,suitable
R3612	T5601	T5600	dobj	function,affect
R3613	T5575	T5576	advmod	more,readily
R3614	T5576	T5577	advmod	readily,accessible
R3615	T5577	T5578	amod	accessible,samples
R3616	T5602	T5601	prep	of,function
R3617	T5578	T5574	pobj	samples,for
R3618	T5579	T5578	punct	", ",samples
R3619	T5580	T5581	amod	such,as
R3620	T5581	T5578	prep	as,samples
R3621	T5603	T5604	nmod	antioxidant,genes
R3622	T5582	T5583	amod	peripheral,blood
R3623	T5604	T5602	pobj	genes,of
R3624	T5583	T5581	pobj	blood,as
R3625	T5584	T5583	cc	or,blood
R3626	T5585	T5586	amod	buccal,smears
R3627	T5586	T5583	conj	smears,blood
R3628	T5605	T5603	cc	and,antioxidant
R3629	T5587	T5570	punct	.,yield
R3630	T5589	T5590	det	A,biomarker
R3631	T5606	T5607	compound	DNA,repair
R3632	T5590	T5591	nsubj	biomarker,is
R3633	T5592	T5590	acl	combining,biomarker
R3634	T5593	T5592	dobj	polymorphisms,combining
R3635	T5607	T5603	conj	repair,antioxidant
R3636	T5594	T5595	dep	that,affect
R3637	T5595	T5593	relcl	affect,polymorphisms
R3638	T5608	T5591	acomp	likely,is
R3639	T5596	T5595	dobj	regulation,affect
R3640	T5597	T5592	prep	with,combining
R3641	T5598	T5597	pobj	those,with
R3642	T5609	T5610	aux	to,be
R3643	T5610	T5608	xcomp	be,likely
R3644	T5611	T5612	det	the,accurate
R3645	T5612	T5610	attr	accurate,be
R3646	T5706	T5707	advmod	virtually,multiplexed
R3647	T5613	T5612	advmod	most,accurate
R3648	T5707	T5709	amod	multiplexed,data
R3649	T5708	T5707	punct	-,multiplexed
R3650	T5614	T5610	prep	for,be
R3651	T5709	T5705	dobj	data,comprising
R3652	T5710	T5711	compound	transcript,abundance
R3653	T5711	T5709	compound	abundance,data
R3654	T5712	T5679	punct	.,improves
R3655	T5714	T5715	advmod	Virtually,multiplexed
R3656	T5615	T5614	pcomp	identifying,for
R3657	T5715	T5717	amod	multiplexed,data
R3658	T5716	T5715	punct	-,multiplexed
R3659	T5616	T5615	dobj	individuals,identifying
R3660	T5717	T5720	nsubj	data,are
R3661	T5718	T5719	compound	transcript,abundance
R3662	T5719	T5717	compound	abundance,data
R3663	T5617	T5616	prep	at,individuals
R3664	T5721	T5722	advmod	highly,suited
R3665	T5722	T5720	acomp	suited,are
R3666	T5618	T5617	pobj	risk,at
R3667	T5723	T5722	prep	to,suited
R3668	T5724	T5723	pobj	identification,to
R3669	T5725	T5724	prep	of,identification
R3670	T5619	T5618	prep	for,risk
R3671	T5726	T5725	pobj	genes,of
R3672	T5727	T5728	dep	that,have
R3673	T5728	T5726	relcl	have,genes
R3674	T5620	T5619	pobj	BC,for
R3675	T5729	T5730	amod	correlated,values
R3676	T5730	T5728	dobj	values,have
R3677	T5621	T5591	punct	.,is
R3678	T5731	T5732	compound	transcript,abundance
R3679	T5732	T5730	compound	abundance,values
R3680	T5623	T5624	nsubj	Biomarkers,improve
R3681	T5625	T5626	dep	that,identify
R3684	T5626	T5623	relcl	identify,Biomarkers
R3687	T5627	T5626	advmod	accurately,identify
R3692	T5628	T5626	dobj	individuals,identify
R3694	T5629	T5628	prep	at,individuals
R3699	T5630	T5629	pobj	risk,at
R3702	T5631	T5630	prep	for,risk
R3708	T5632	T5631	pobj	BC,for
R3709	T5633	T5624	aux	will,improve
R3710	T5634	T5624	dobj	efficacy,improve
R3711	T5635	T5634	prep	of,efficacy
R3712	T5636	T5635	pobj	chemoprevention,of
R3713	T5637	T5634	cc	and,efficacy
R3714	T5638	T5639	amod	early,detection
R3715	T5639	T5640	nmod	detection,trials
R3716	T5640	T5634	conj	trials,efficacy
R3717	T5641	T5640	amod	clinical,trials
R3718	T5642	T5624	punct	.,improve
R3719	T5644	T5645	det	The,variation
R3720	T5645	T5648	nsubj	variation,provides
R3721	T5646	T5645	amod	observed,variation
R3722	T5647	T5645	amod	inter-sample,variation
R3723	T5649	T5645	prep	in,variation
R3724	T5650	T5651	det	the,presence
R3725	T5651	T5649	pobj	presence,in
R3726	T5652	T5651	prep	of,presence
R3727	T5653	T5654	npadvmod	gene,specific
R3728	T5654	T5656	amod	specific,inhibitors
R3729	T5655	T5654	punct	-,specific
R3730	T5656	T5652	pobj	inhibitors,of
R3731	T5657	T5656	prep	of,inhibitors
R3732	T5658	T5657	pobj	PCR,of
R3733	T5659	T5648	dobj	evidence,provides
R3734	T5660	T5659	acl	supporting,evidence
R3735	T5661	T5662	det	the,need
R3736	T5662	T5660	dobj	need,supporting
R3737	T5663	T5662	prep	for,need
R3738	T5664	T5663	pobj	inclusion,for
R3739	T5665	T5664	prep	of,inclusion
R3740	T5666	T5667	det	an,standard
R3741	T5667	T5665	pobj	standard,of
R3742	T5668	T5667	amod	internal,standard
R3743	T5669	T5664	prep	in,inclusion
R3744	T5670	T5671	det	each,measurement
R3745	T5671	T5669	pobj	measurement,in
R3746	T5672	T5671	amod	quantitative,measurement
R3747	T5673	T5671	compound	PCR,measurement
R3748	T5674	T5675	compound	transcript,abundance
R3749	T5675	T5671	compound	abundance,measurement
R3750	T5676	T5648	punct	.,provides
R3751	T5678	T5679	csubj	Including,improves
R3752	T5680	T5681	amod	such,standards
R3753	T5681	T5678	dobj	standards,Including
R3754	T5682	T5681	amod	internal,standards
R3755	T5683	T5678	prep	in,Including
R3756	T5684	T5685	det	the,form
R3757	T5685	T5683	pobj	form,in
R3758	T5686	T5685	prep	of,form
R3759	T5687	T5688	amod	standardized,mixtures
R3760	T5688	T5686	pobj	mixtures,of
R3761	T5689	T5688	prep	of,mixtures
R3762	T5690	T5691	amod	internal,standards
R3763	T5691	T5689	pobj	standards,of
R3764	T5692	T5693	det	the,reproducibility
R3765	T5693	T5679	dobj	reproducibility,improves
R3766	T5694	T5693	prep	of,reproducibility
R3767	T5695	T5696	compound	transcript,abundance
R3768	T5696	T5697	compound	abundance,measurement
R3769	T5697	T5694	pobj	measurement,of
R3770	T5698	T5679	cc	and,improves
R3771	T5699	T5679	conj	enables,improves
R3772	T5700	T5699	dobj	development,enables
R3773	T5701	T5700	prep	of,development
R3774	T5702	T5703	det	a,database
R3775	T5703	T5701	pobj	database,of
R3776	T5704	T5703	amod	standardized,database
R3777	T5705	T5703	acl	comprising,database
R3778	T5794	T5795	nsubj	We,conclude
R3779	T5796	T5797	mark	that,regulates
R3780	T5797	T5795	advcl	regulates,conclude
R3781	T5798	T5797	prep	in,regulates
R3782	T5799	T5800	amod	non-BC,individuals
R3783	T5800	T5798	pobj	individuals,in
R3784	T5801	T5797	punct	", ",regulates
R3785	T5802	T5797	nsubj	CEBPG,regulates
R3786	T5803	T5797	dobj	transcription,regulates
R3787	T5804	T5803	prep	of,transcription
R3788	T5805	T5806	amod	key,genes
R3789	T5806	T5804	pobj	genes,of
R3790	T5807	T5806	nmod	antioxidant,genes
R3791	T5808	T5807	cc	or,antioxidant
R3792	T5809	T5810	compound	DNA,repair
R3793	T5810	T5807	conj	repair,antioxidant
R3794	T5811	T5797	prep	in,regulates
R3795	T5812	T5811	pobj	NBEC,in
R3796	T5813	T5797	cc	and,regulates
R3797	T5814	T5815	mark	that,is
R3798	T5815	T5797	conj	is,regulates
R3799	T5816	T5815	prep	in,is
R3800	T5817	T5816	pobj	smokers,in
R3801	T5818	T5819	dep	who,develop
R3802	T5819	T5817	relcl	develop,smokers
R3803	T5820	T5819	dobj	BC,develop
R3804	T5821	T5815	punct	", ",is
R3805	T5822	T5823	compound	CEBPG,regulation
R3806	T5823	T5815	nsubj	regulation,is
R3807	T5824	T5815	acomp	sub-optimal,is
R3808	T5825	T5826	mark	for,cause
R3809	T5826	T5824	advcl	cause,sub-optimal
R3810	T5827	T5828	det	a,number
R3811	T5828	T5826	nsubj	number,cause
R3812	T5829	T5828	amod	sufficient,number
R3813	T5830	T5828	prep	of,number
R3814	T5831	T5832	nmod	antioxidant,genes
R3815	T5832	T5830	pobj	genes,of
R3816	T5833	T5831	cc	and,antioxidant
R3817	T5834	T5833	punct	/,and
R3818	T5835	T5833	cc	or,and
R3819	T5836	T5837	compound	DNA,repair
R3820	T5837	T5831	conj	repair,antioxidant
R3821	T5838	T5826	aux	to,cause
R3822	T5839	T5840	amod	increased,risk
R3823	T5840	T5826	dobj	risk,cause
R3824	T5841	T5795	punct	.,conclude
R3825	T5842	T5843	det	The,history
R3826	T5843	T5845	nsubjpass	history,accessed
R3827	T5844	T5843	amod	pre-publication,history
R3828	T5846	T5843	prep	for,history
R3829	T5847	T5848	det	this,paper
R3830	T5848	T5846	pobj	paper,for
R3831	T5849	T5845	aux	can,accessed
R3832	T5850	T5845	auxpass	be,accessed
R3833	T5851	T5845	advmod	here,accessed
R3834	T5852	T5845	punct	:,accessed
R2297	T3511	T3509	pobj	smokers,between
R1809	T2750	T2753	nsubjpass	data,obtained
R1848	T2793	T2796	nsubjpass	standard,observed
R1880	T2828	T2826	pobj	products,in
R816	T1390	T1391	compound	NBEC,sample
R817	T1391	T1392	compound	sample,procurement
R818	T1394	T1395	compound	Brush,samples
R821	T1398	T1395	prep	of,samples
R822	T1399	T1400	amod	normal,epithelium
R825	T1402	T1397	auxpass	were,obtained
R826	T1403	T1397	prep	for,obtained
R827	T1404	T1405	compound	research,studies
R828	T1405	T1403	pobj	studies,for
R829	T1406	T1397	prep	at,obtained
R830	T1407	T1408	det	the,time
R831	T1408	T1406	pobj	time,at
R832	T1409	T1408	prep	of,time
R833	T1410	T1411	amod	diagnostic,bronchoscopy
R834	T1411	T1409	pobj	bronchoscopy,of
R835	T1412	T1397	prep	according,obtained
R836	T1413	T1412	prep	to,according
R837	T1414	T1415	advmod	previously,described
R838	T1415	T1416	amod	described,methods
R839	T1416	T1413	pobj	methods,to
R840	T1417	T1418	punct	[,11
R844	T1421	T1418	punct	],11
R845	T1422	T1397	punct	.,obtained
R846	T1424	T1425	amod	Normal,epithelium
R849	T1428	T1425	prep	in,epithelium
R850	T1429	T1430	det	the,lung
R851	T1430	T1428	pobj	lung,in
R852	T1431	T1432	neg	not,involved
R853	T1432	T1430	acl	involved,lung
R854	T1433	T1432	prep	with,involved
R855	T1434	T1433	pobj	cancer,with
R856	T1435	T1427	auxpass	was,brushed
R857	T1436	T1437	amod	prior,to
R858	T1437	T1427	prep	to,brushed
R859	T1438	T1437	pobj	biopsy,to
R860	T1439	T1438	prep	of,biopsy
R861	T1440	T1441	det	the,area
R865	T1444	T1427	punct	.,brushed
R866	T1446	T1447	nsubjpass	Samples,collected
R867	T1448	T1447	auxpass	were,collected
R868	T1449	T1447	prep	in,collected
R869	T1450	T1451	det	a,manner
R870	T1451	T1449	pobj	manner,in
R871	T1452	T1451	acl	satisfying,manner
R872	T1453	T1454	det	all,requirements
R873	T1454	T1452	dobj	requirements,satisfying
R874	T1455	T1454	prep	of,requirements
R875	T1456	T1457	det	the,Board
R879	T1460	T1457	prep	for,Board
R880	T1461	T1462	det	the,University
R883	T1464	T1462	prep	of,University
R884	T1465	T1464	pobj	Ohio,of
R885	T1466	T1447	punct	.,collected
R886	T1468	T1469	det	Each,diagnosis
R889	T1472	T1469	cc	and,diagnosis
R890	T1473	T1474	compound	subtype,identification
R891	T1474	T1469	conj	identification,diagnosis
R892	T1475	T1471	auxpass	was,determined
R893	T1476	T1471	prep	by,determined
R894	T1477	T1478	amod	histopathological,examination
R895	T1478	T1476	pobj	examination,by
R896	T1479	T1471	prep	in,determined
R897	T1480	T1481	det	the,Department
R898	T1481	T1479	pobj	Department,in
R899	T1482	T1481	prep	of,Department
R900	T1483	T1482	pobj	Pathology,of
R901	T1484	T1481	prep	at,Department
R902	T1485	T1486	det	the,University
R905	T1488	T1486	prep	of,University
R906	T1489	T1488	pobj	Ohio,of
R907	T1490	T1471	punct	.,determined
R908	T1492	T1493	compound	NBEC,samples
R909	T1493	T1494	nsubjpass	samples,evaluated
R910	T1495	T1493	prep	from,samples
R911	T1496	T1497	det	a,total
R912	T1497	T1495	pobj	total,from
R913	T1498	T1497	prep	of,total
R914	T1499	T1500	nummod	49,individuals
R915	T1500	T1498	pobj	individuals,of
R916	T1501	T1500	punct	", ",individuals
R917	T1502	T1500	prep	including,individuals
R918	T1503	T1504	nummod	24,individuals
R921	T1506	T1504	cc	and,individuals
R922	T1507	T1508	nummod	25,individuals
R925	T1510	T1494	punct	", ",evaluated
R926	T1511	T1494	auxpass	were,evaluated
R927	T1512	T1494	prep	in,evaluated
R928	T1513	T1514	det	this,study
R929	T1514	T1512	pobj	study,in
R930	T1515	T1494	punct	.,evaluated
R931	T1517	T1518	det	The,characteristics
R934	T1521	T1518	prep	of,characteristics
R935	T1522	T1523	det	these,individuals
R936	T1523	T1521	pobj	individuals,of
R937	T1524	T1520	auxpass	are,presented
R938	T1525	T1520	prep	in,presented
R939	T1526	T1525	pobj	Table,in
R940	T1527	T1526	nummod	1,Table
R941	T1528	T1520	punct	.,presented
R1396	T2162	T2163	amod	Statistical,analysis
R1397	T2165	T2166	amod	More,"6,000"
R1403	T2172	T2171	auxpass	were,conducted
R1404	T2173	T2171	prep	in,conducted
R1405	T2174	T2175	amod	multiple,experiments
R1406	T2175	T2173	pobj	experiments,in
R1407	T2176	T2171	prep	over,conducted
R1408	T2177	T2178	nummod	two,years
R1409	T2178	T2176	pobj	years,over
R1410	T2179	T2180	aux	to,assess
R1411	T2180	T2171	advcl	assess,conducted
R1412	T2181	T2182	det	the,factors
R1416	T2185	T2182	cc	and,factors
R1417	T2186	T2187	nummod	sixteen,genes
R1423	T2192	T2180	prep	in,assess
R1424	T2193	T2194	compound	NBEC,samples
R1425	T2194	T2192	pobj	samples,in
R1426	T2195	T2194	prep	from,samples
R1427	T2196	T2197	nummod	49,individuals
R1428	T2197	T2195	pobj	individuals,from
R1429	T2198	T2199	punct	(,individuals
R1433	T2202	T2199	cc	and,individuals
R1434	T2203	T2204	nummod	25,individuals
R1437	T2206	T2199	punct	),individuals
R1438	T2207	T2171	punct	.,conducted
R1439	T2209	T2210	nsubjpass	Correlation,determined
R1440	T2211	T2209	prep	of,Correlation
R1441	T2212	T2211	pobj	each,of
R1442	T2213	T2212	prep	of,each
R1443	T2214	T2215	det	the,factors
R1447	T2218	T2209	prep	with,Correlation
R1448	T2219	T2218	pobj	each,with
R1449	T2220	T2219	prep	of,each
R1450	T2221	T2222	det	the,genes
R1456	T2227	T2210	auxpass	was,determined
R1457	T2228	T2210	prep	by,determined
R1458	T2229	T2230	poss	Pearson,correlation
R1461	T2232	T2230	prep	following,correlation
R1462	T2233	T2234	amod	logarithmic,transformation
R1463	T2234	T2232	pobj	transformation,following
R1464	T2235	T2210	punct	.,determined
R1465	T2237	T2238	det	The,transformation
R1466	T2238	T2239	nsubj	transformation,was
R1467	T2240	T2239	acomp	necessary,was
R1468	T2241	T2239	prep	due,was
R1469	T2242	T2241	pcomp	to,due
R1470	T2243	T2244	det	the,variation
R1474	T2247	T2244	prep	in,variation
R1475	T2248	T2247	pobj	expression,in
R1476	T2249	T2248	prep	of,expression
R1477	T2250	T2251	det	each,gene
R1478	T2251	T2249	pobj	gene,of
R1479	T2252	T2244	prep	among,variation
R1480	T2253	T2254	det	the,individuals
R1481	T2254	T2252	pobj	individuals,among
R1482	T2255	T2239	punct	.,was
R1483	T2257	T2258	compound	Significance,level
R1484	T2258	T2259	nsubjpass	level,defined
R1485	T2260	T2259	auxpass	was,defined
R1486	T2261	T2259	prep	as,defined
R1487	T2262	T2261	pobj	p,as
R1488	T2263	T2264	punct	<,0.01
R1489	T2264	T2262	amod	0.01,p
R1490	T2265	T2259	prep	following,defined
R1491	T2266	T2267	compound	Bonferroni,adjustment
R1492	T2267	T2265	pobj	adjustment,following
R1493	T2268	T2267	prep	for,adjustment
R1494	T2269	T2270	amod	multiple,comparison
R1495	T2270	T2268	pobj	comparison,for
R1496	T2271	T2270	punct	", ",comparison
R1497	T2272	T2273	advmod	specifically,comparison
R1498	T2273	T2270	appos	comparison,comparison
R1499	T2274	T2273	prep	of,comparison
R1500	T2275	T2274	pobj	each,of
R1501	T2276	T2275	prep	of,each
R1502	T2277	T2278	nummod	six,factors
R1505	T2280	T2273	prep	to,comparison
R1506	T2281	T2280	pobj	each,to
R1507	T2282	T2281	prep	of,each
R1508	T2283	T2284	det	the,genes
R1514	T2289	T2259	punct	.,defined
R1515	T2291	T2292	nsubjpass	Comparison,done
R1516	T2293	T2291	prep	for,Comparison
R1517	T2294	T2295	amod	significant,differences
R1518	T2295	T2293	pobj	differences,for
R1519	T2296	T2291	prep	between,Comparison
R1520	T2297	T2296	pobj	pairs,between
R1521	T2298	T2297	prep	of,pairs
R1522	T2299	T2300	compound	correlation,coefficients
R1523	T2300	T2298	pobj	coefficients,of
R1524	T2301	T2292	auxpass	was,done
R1525	T2302	T2292	prep	by,done
R1526	T2303	T2304	poss	Fisher,test
R1530	T2307	T2304	compound	transformation,test
R1532	T2309	T2310	punct	[,16
R1533	T2310	T2292	parataxis	16,done
R1534	T2311	T2310	punct	],16
R1535	T2312	T2292	punct	.,done
R1536	T2314	T2315	nsubjpass	Analysis,assessed
R1537	T2316	T2314	prep	of,Analysis
R1538	T2317	T2318	det	the,relationship
R1539	T2318	T2316	pobj	relationship,of
R1540	T2319	T2318	prep	between,relationship
R1541	T2320	T2321	advmod	virtually,multiplexed
R1547	T2326	T2318	prep	for,relationship
R1548	T2327	T2328	det	each,gene
R1549	T2328	T2326	pobj	gene,for
R1550	T2329	T2318	prep	with,relationship
R1551	T2330	T2329	pobj	age,with
R1552	T2331	T2315	auxpass	was,assessed
R1553	T2332	T2315	prep	by,assessed
R1554	T2333	T2334	poss	Pearson,correlation
R1557	T2336	T2315	punct	", ",assessed
R1558	T2337	T2315	prep	with,assessed
R1559	T2338	T2337	pobj	gender,with
R1560	T2339	T2338	prep	by,gender
R1561	T2340	T2341	compound	t,test
R1564	T2343	T2337	punct	", ",with
R1565	T2344	T2337	cc	and,with
R1566	T2345	T2337	conj	with,with
R1567	T2346	T2347	compound	smoking,history
R1568	T2347	T2345	pobj	history,with
R1569	T2348	T2347	prep	by,history
R1570	T2349	T2348	pobj	ANOVA,by
R1571	T2350	T2349	acl	followed,ANOVA
R1572	T2351	T2350	agent	by,followed
R1573	T2352	T2353	poss	Duncan,test
R1576	T2355	T2315	punct	.,assessed
R1593	T2499	T2497	pobj	package,from
R1615	T2521	T2514	parataxis	pairs,pairs
R1634	T2540	T2512	parataxis	GmbH,define
R1655	T2563	T2561	pobj	program,from
R1686	T2594	T2581	parataxis	GmbH,program
R1711	T2621	T2613	conj	similarity,similarity
R1758	T2672	T2670	pobj	levels,at
R1935	T3095	T3098	nummod	16,genes
R1993	T3157	T3155	pobj	factors,of
R2057	T3225	T3223	pobj	genes,of
R2107	T3279	T3277	pobj	analysis,from
R2234	T3416	T3414	pobj	factors,of
R2	T268	T266	compound	transcription,factor
R6	T273	T271	cc	and,antioxidant
R7	T274	T275	compound	DNA,repair
R8	T275	T271	conj	repair,antioxidant
R12	T279	T278	amod	bronchial,cells
R13	T280	T278	amod	epithelial,cells
R25	T297	T296	amod	primary,cause
R36	T308	T307	quantmod	10,15
R37	T309	T307	punct	–,15
R40	T312	T310	prep	of,%
R41	T313	T314	amod	heavy,smokers
R42	T314	T312	pobj	smokers,of
R50	T322	T323	det	this,variation
R51	T323	T321	nsubjpass	variation,determined
R52	T324	T323	prep	in,variation
R53	T325	T324	pobj	risk,in
R54	T326	T321	auxpass	is,determined
R55	T327	T321	punct	", ",determined
R56	T328	T321	prep	in,determined
R57	T329	T328	amod	part,in
R58	T330	T321	punct	", ",determined
R59	T331	T321	advmod	genetically,determined
R70	T344	T342	pobj	which,for
R71	T345	T346	compound	transcript,abundance
R72	T346	T343	nsubj	abundance,was
R77	T351	T350	amod	bronchial,cells
R78	T352	T350	amod	epithelial,cells
R96	T372	T371	amod	same,samples
R97	T373	T371	compound	NBEC,samples
R101	T377	T376	compound	abundance,values
R105	T381	T382	compound	DNA,repair
R106	T382	T380	compound	repair,genes
R111	T387	T386	compound	antioxidant,genes
R120	T398	T399	nmod	antioxidant,genes
R125	T403	T397	auxpass	are,co-regulated
R129	T407	T405	cc	or,one
R130	T408	T405	conj	more,one
R131	T409	T406	compound	transcription,factors
R135	T413	T414	amod	inter-individual,variation
R136	T414	T412	nsubj	variation,is
R137	T415	T414	prep	in,variation
R138	T416	T415	pobj	expression,in
R139	T417	T416	cc	and,expression
R140	T418	T417	punct	/,and
R141	T419	T417	cc	or,and
R142	T420	T416	conj	function,expression
R143	T421	T416	prep	of,expression
R144	T422	T421	pobj	one,of
R145	T423	T422	cc	or,one
R146	T424	T422	conj	more,one
R147	T425	T422	prep	of,one
R148	T426	T427	det	these,factors
R162	T443	T442	amod	putative,sites
R163	T444	T445	compound	transcription,factor
R164	T445	T446	compound	factor,recognition
R165	T446	T442	compound	recognition,sites
R172	T454	T453	compound	antioxidant,genes
R178	T460	T461	compound	DNA,sequence
R179	T461	T459	compound	sequence,analysis
R183	T466	T465	compound	transcript,values
R184	T467	T465	compound	abundance,values
R188	T472	T471	compound	transcription,factors
R191	T475	T474	nsubj	n,6
R192	T476	T474	punct	=,6
R197	T481	T480	amod	expanded,group
R201	T485	T483	cc	and,antioxidant
R202	T486	T487	compound	DNA,repair
R203	T487	T483	conj	repair,antioxidant
R206	T490	T489	nsubj	n,16
R207	T491	T489	punct	=,16
R226	T513	T512	compound	transcription,factor
R231	T519	T518	nsubj	p,0.01
R232	T520	T518	punct	<,0.01
R239	T527	T526	nmod	antioxidant,genes
R240	T528	T527	cc	or,antioxidant
R241	T529	T530	compound	DNA,repair
R242	T530	T527	conj	repair,antioxidant
R261	T551	T552	punct	(,0.01
R265	T555	T552	punct	),0.01
R297	T588	T587	amod	only,factor
R298	T589	T587	amod	other,factor
R299	T590	T587	compound	transcription,factor
R306	T598	T597	nummod	five,genes
R307	T599	T597	compound	target,genes
R324	T618	T616	pobj	contrast,in
R325	T619	T618	prep	to,contrast
R326	T620	T619	pobj	CEBPG,to
R327	T621	T617	punct	", ",was
R328	T622	T617	expl	there,was
R331	T625	T624	amod	significant,difference
R346	T644	T643	nsubj	CEBPG,is
R349	T647	T646	compound	transcription,factor
R358	T656	T655	nmod	antioxidant,genes
R359	T657	T656	cc	and,antioxidant
R360	T658	T659	compound	DNA,repair
R361	T659	T656	conj	repair,antioxidant
R371	T671	T672	det	the,smokers
R374	T674	T672	acl	selected,smokers
R375	T675	T674	prep	for,selected
R376	T676	T675	pobj	development,for
R377	T677	T676	prep	of,development
R378	T678	T677	pobj	BC,of
R387	T687	T685	cc	and,antioxidant
R388	T688	T689	compound	DNA,repair
R389	T689	T685	conj	repair,antioxidant
R394	T923	T924	nsubj	BC,is
R395	T925	T924	advmod	currently,is
R396	T926	T927	det	the,cause
R399	T929	T927	prep	of,cause
R400	T930	T931	npadvmod	cancer,related
R403	T933	T929	pobj	death,of
R404	T934	T924	prep	in,is
R405	T935	T936	det	the,States
R408	T938	T924	punct	", ",is
R409	T939	T924	advcl	causing,is
R410	T940	T941	nummod	28,%
R411	T941	T939	dobj	%,causing
R412	T942	T941	prep	of,%
R413	T943	T944	det	all,deaths
R416	T946	T947	punct	[,1
R417	T947	T924	parataxis	1,is
R418	T948	T947	punct	],1
R419	T949	T924	punct	.,is
R420	T951	T952	mark	Although,is
R424	T956	T957	det	the,factor
R428	T960	T955	punct	", ",develop
R429	T961	T962	advmod	only,15
R433	T965	T955	nsubj	%,develop
R434	T966	T965	prep	of,%
R435	T967	T968	amod	heavy,smokers
R436	T968	T966	pobj	smokers,of
R437	T969	T970	punct	(,years
R440	T972	T974	nummod	20,pack
R443	T975	T970	punct	),years
R444	T976	T955	dobj	BC,develop
R445	T977	T978	punct	[,1
R446	T978	T955	parataxis	1,develop
R447	T979	T980	punct	-,3
R448	T980	T978	prep	3,1
R449	T981	T978	punct	],1
R450	T982	T955	punct	.,develop
R451	T984	T985	nmod	Antioxidant,enzymes
R456	T990	T991	dep	that,provide
R457	T991	T985	relcl	provide,enzymes
R458	T992	T991	dobj	protection,provide
R459	T993	T992	prep	from,protection
R460	T994	T995	det	the,effects
R461	T995	T993	pobj	effects,from
R462	T996	T995	prep	of,effects
R463	T997	T998	compound	cigarette,smoke
R464	T998	T996	pobj	smoke,of
R465	T999	T989	auxpass	are,expressed
R466	T1000	T989	prep	in,expressed
R467	T1001	T1002	det	the,cells
R470	T1004	T1002	prep	for,cells
R471	T1005	T1004	pobj	BC,for
R472	T1006	T1002	punct	", ",cells
R473	T1007	T1008	amod	normal,cells
R477	T1011	T1008	punct	(,cells
R478	T1012	T1008	appos	NBEC,cells
R479	T1013	T989	punct	),expressed
R480	T1014	T1015	punct	[,1
R481	T1015	T989	parataxis	1,expressed
R482	T1016	T1015	punct	],1
R483	T1017	T989	punct	.,expressed
R484	T1019	T1020	amod	Inherited,variation
R487	T1023	T1020	prep	in,variation
R488	T1024	T1025	det	the,function
R489	T1025	T1023	pobj	function,in
R490	T1026	T1025	prep	of,function
R491	T1027	T1028	det	these,genes
R492	T1028	T1026	pobj	genes,of
R493	T1029	T1030	det	a,role
R494	T1030	T1022	dobj	role,plays
R495	T1031	T1022	prep	in,plays
R496	T1032	T1031	pcomp	determining,in
R497	T1033	T1032	dobj	risk,determining
R498	T1034	T1033	prep	for,risk
R499	T1035	T1034	pobj	BC,for
R500	T1036	T1037	punct	[,4
R501	T1037	T1022	parataxis	4,plays
R502	T1038	T1039	punct	-,6
R503	T1039	T1037	prep	6,4
R504	T1040	T1037	punct	],4
R505	T1041	T1022	punct	.,plays
R506	T1043	T1044	compound	Antioxidant,enzymes
R507	T1044	T1045	nsubj	enzymes,protect
R508	T1046	T1045	dobj	NBEC,protect
R509	T1047	T1045	prep	from,protect
R510	T1048	T1049	amod	reactive,species
R513	T1051	T1049	acl	produced,species
R514	T1052	T1051	agent	by,produced
R515	T1053	T1052	pobj	interaction,by
R516	T1054	T1053	prep	with,interaction
R517	T1055	T1053	cc	and,interaction
R518	T1056	T1057	nmod	metabolism,xenobiotics
R521	T1059	T1060	amod	such,as
R522	T1060	T1057	prep	as,xenobiotics
R523	T1061	T1060	pobj	pollution,as
R524	T1062	T1061	cc	and,pollution
R525	T1063	T1064	compound	cigarette,smoke
R526	T1064	T1061	conj	smoke,pollution
R527	T1065	T1066	punct	[,4
R528	T1066	T1051	parataxis	4,produced
R529	T1067	T1068	punct	-,7
R530	T1068	T1066	prep	7,4
R531	T1069	T1066	punct	],4
R532	T1070	T1071	advmod	as,as
R535	T1073	T1049	conj	those,species
R536	T1074	T1073	acl	produced,those
R537	T1075	T1074	agent	by,produced
R538	T1076	T1077	amod	normal,metabolism
R541	T1079	T1045	punct	.,protect
R542	T1081	T1082	amod	Reactive,species
R545	T1085	T1086	amod	many,reactions
R548	T1088	T1086	prep	including,reactions
R549	T1089	T1088	pobj	denaturation,including
R550	T1090	T1089	prep	of,denaturation
R551	T1091	T1090	pobj	proteins,of
R552	T1092	T1089	punct	", ",denaturation
R553	T1093	T1089	conj	cross-linking,denaturation
R554	T1094	T1093	prep	of,cross-linking
R555	T1095	T1094	pobj	lipids,of
R556	T1096	T1095	cc	and,lipids
R557	T1097	T1095	conj	proteins,lipids
R558	T1098	T1093	cc	and,cross-linking
R559	T1099	T1093	conj	modification,cross-linking
R560	T1100	T1099	prep	of,modification
R561	T1101	T1102	amod	nucleic,acid
R562	T1102	T1103	compound	acid,bases
R563	T1103	T1100	pobj	bases,of
R564	T1104	T1086	punct	", ",reactions
R565	T1105	T1106	dep	which,lead
R568	T1108	T1106	prep	to,lead
R569	T1109	T1108	pobj	cancer,to
R570	T1110	T1111	punct	[,7
R571	T1111	T1084	parataxis	7,cause
R572	T1112	T1111	punct	],7
R573	T1113	T1084	punct	.,cause
R574	T1115	T1116	compound	DNA,repair
R575	T1116	T1117	compound	repair,enzymes
R576	T1117	T1118	nsubj	enzymes,repair
R577	T1119	T1120	det	the,damage
R580	T1122	T1120	prep	to,damage
R581	T1123	T1122	pobj	DNA,to
R582	T1124	T1120	acl	caused,damage
R583	T1125	T1124	agent	by,caused
R584	T1126	T1127	compound	oxidant,stress
R585	T1127	T1125	pobj	stress,by
R586	T1128	T1129	advmod	as,as
R589	T1131	T1132	amod	other,stresses
R590	T1132	T1127	conj	stresses,stress
R591	T1133	T1120	punct	", ",damage
R592	T1134	T1120	prep	including,damage
R593	T1135	T1136	amod	bulky,adducts
R594	T1136	T1134	pobj	adducts,including
R595	T1137	T1136	acl	derived,adducts
R596	T1138	T1137	prep	from,derived
R597	T1139	T1138	pobj	carcinogens,from
R598	T1140	T1139	prep	in,carcinogens
R599	T1141	T1142	compound	cigarette,smoke
R600	T1142	T1140	pobj	smoke,in
R601	T1143	T1144	punct	[,8
R602	T1144	T1118	parataxis	8,repair
R603	T1145	T1144	punct	],8
R604	T1146	T1118	punct	.,repair
R605	T1148	T1149	nsubj	We,reported
R606	T1150	T1149	advmod	previously,reported
R607	T1151	T1152	mark	that,was
R617	T1161	T1152	acomp	lower,was
R618	T1162	T1152	prep	in,was
R619	T1163	T1162	pobj	NBEC,in
R620	T1164	T1163	prep	of,NBEC
R621	T1165	T1166	compound	BC,individuals
R622	T1166	T1164	pobj	individuals,of
R623	T1167	T1152	prep	compared,was
R624	T1168	T1167	prep	to,compared
R625	T1169	T1170	amod	non-BC,individuals
R626	T1170	T1168	pobj	individuals,to
R627	T1171	T1149	punct	", ",reported
R628	T1172	T1149	advcl	suggesting,reported
R629	T1173	T1174	mark	that,selected
R634	T1178	T1174	prep	on,selected
R635	T1179	T1180	det	the,basis
R636	T1180	T1178	pobj	basis,on
R637	T1181	T1180	prep	of,basis
R638	T1182	T1183	amod	poor,protection
R641	T1185	T1186	punct	[,9
R642	T1186	T1149	parataxis	9,reported
R643	T1187	T1186	punct	],9
R644	T1188	T1149	punct	.,reported
R645	T1190	T1191	prep	In,was
R646	T1192	T1193	det	that,study
R647	T1193	T1190	pobj	study,In
R648	T1194	T1191	punct	", ",was
R649	T1195	T1191	expl	there,was
R650	T1196	T1197	det	a,tendency
R651	T1197	T1191	attr	tendency,was
R652	T1198	T1197	prep	towards,tendency
R653	T1199	T1198	pobj	correlation,towards
R654	T1200	T1199	prep	in,correlation
R655	T1201	T1202	compound	transcript,abundance
R656	T1202	T1200	pobj	abundance,in
R657	T1203	T1199	prep	between,correlation
R658	T1204	T1205	amod	several,pairs
R659	T1205	T1203	pobj	pairs,between
R660	T1206	T1205	prep	of,pairs
R661	T1207	T1208	nmod	antioxidant,genes
R666	T1212	T1191	prep	in,was
R667	T1213	T1214	amod	non-BC,individuals
R668	T1214	T1212	pobj	individuals,in
R669	T1215	T1212	punct	", ",in
R670	T1216	T1212	cc	but,in
R671	T1217	T1216	neg	not,but
R672	T1218	T1212	conj	in,in
R673	T1219	T1220	compound	BC,individuals
R674	T1220	T1218	pobj	individuals,in
R675	T1221	T1191	punct	.,was
R676	T1223	T1224	compound	Gene,pairs
R677	T1224	T1225	nsubj	pairs,were
R678	T1226	T1224	acl	included,pairs
R679	T1227	T1226	prep	in,included
R680	T1228	T1229	det	that,observation
R681	T1229	T1227	pobj	observation,in
R682	T1230	T1231	compound	GSTP1,GPX1
R685	T1233	T1231	punct	", ",GPX1
R686	T1234	T1235	compound	CAT,GPX3
R689	T1237	T1235	punct	", ",GPX3
R690	T1238	T1235	cc	and,GPX3
R691	T1239	T1240	compound	GPX3,SOD1
R694	T1242	T1225	punct	.,were
R695	T1244	T1245	nsubj	Correlation,is
R696	T1246	T1247	nummod	one,characteristic
R699	T1249	T1247	prep	of,characteristic
R700	T1250	T1251	amod	co-regulated,genes
R701	T1251	T1249	pobj	genes,of
R702	T1252	T1245	punct	.,is
R703	T1254	T1255	nsubj	Another,is
R704	T1256	T1257	amod	shared,sites
R709	T1261	T1255	prep	in,is
R710	T1262	T1263	det	the,regions
R713	T1265	T1263	prep	of,regions
R714	T1266	T1267	det	those,genes
R715	T1267	T1265	pobj	genes,of
R716	T1268	T1269	punct	[,10
R717	T1269	T1255	parataxis	10,is
R718	T1270	T1269	punct	],10
R719	T1271	T1255	punct	.,is
R720	T1273	T1274	prep	Based,hypothesized
R721	T1275	T1273	prep	on,Based
R722	T1276	T1277	det	the,findings
R725	T1279	T1274	punct	", ",hypothesized
R726	T1280	T1274	nsubjpass	it,hypothesized
R727	T1281	T1274	auxpass	was,hypothesized
R728	T1282	T1283	advmod	first,is
R733	T1287	T1288	amod	inter-individual,variation
R734	T1288	T1283	attr	variation,is
R735	T1289	T1283	prep	in,is
R736	T1290	T1289	pobj	regulation,in
R737	T1291	T1290	prep	of,regulation
R738	T1292	T1293	amod	key,genes
R744	T1298	T1290	prep	by,regulation
R745	T1299	T1300	nummod	one,factors
R750	T1304	T1283	cc	and,is
R751	T1305	T1306	advmod	second,selected
R760	T1314	T1306	prep	for,selected
R761	T1315	T1314	pobj	development,for
R762	T1316	T1315	prep	of,development
R763	T1317	T1316	pobj	BC,of
R764	T1318	T1319	mark	if,smoke
R767	T1321	T1319	dobj	cigarettes,smoke
R768	T1322	T1274	punct	.,hypothesized
R769	T1324	T1325	aux	To,test
R770	T1325	T1326	advcl	test,identified
R771	T1327	T1328	det	these,hypotheses
R772	T1328	T1325	dobj	hypotheses,test
R773	T1329	T1326	punct	", ",identified
R774	T1330	T1331	compound	transcription,factor
R775	T1331	T1332	compound	factor,sites
R778	T1334	T1332	amod	common,sites
R779	T1335	T1334	prep	to,common
R780	T1336	T1337	det	the,regions
R783	T1339	T1337	prep	of,regions
R784	T1340	T1341	det	the,pairs
R789	T1345	T1326	auxpass	were,identified
R790	T1346	T1326	prep	through,identified
R791	T1347	T1348	advmod	in,silico
R792	T1348	T1349	amod	silico,analysis
R796	T1352	T1326	punct	", ",identified
R797	T1353	T1326	cc	and,identified
R798	T1354	T1355	poss	their,abundance
R801	T1357	T1326	conj	measured,identified
R802	T1358	T1357	advmod	simultaneously,measured
R803	T1359	T1358	prep	with,simultaneously
R804	T1360	T1361	det	an,group
R807	T1363	T1361	prep	of,group
R808	T1364	T1365	nummod	ten,antioxidant
R809	T1365	T1366	nmod	antioxidant,genes
R813	T1369	T1365	conj	repair,antioxidant
R815	T1371	T1326	punct	.,identified
R942	T1605	T1606	compound	Transcript,abundance
R943	T1606	T1607	compound	abundance,measurement
R944	T1609	T1610	amod	Total,samples
R947	T1613	T1610	acl	extracted,samples
R948	T1614	T1613	prep	from,extracted
R949	T1615	T1614	pobj	NBEC,from
R950	T1616	T1612	auxpass	were,transcribed
R951	T1617	T1612	advmod	reverse,transcribed
R952	T1618	T1612	advcl	using,transcribed
R953	T1619	T1620	nmod	M,MLV
R958	T1624	T1622	cc	and,transcriptase
R959	T1625	T1626	compound	oligo,dT
R960	T1626	T1627	compound	dT,primers
R961	T1627	T1622	conj	primers,transcriptase
R962	T1628	T1629	mark	as,described
R965	T1631	T1632	punct	[,11
R969	T1635	T1632	punct	],11
R970	T1636	T1612	punct	.,transcribed
R971	T1638	T1639	amod	Standardized,RT
R972	T1639	T1640	nmod	RT,PCR
R978	T1646	T1645	auxpass	was,used
R979	T1647	T1645	prep	for,used
R980	T1648	T1649	compound	transcript,abundance
R981	T1649	T1650	compound	abundance,measurement
R982	T1650	T1647	pobj	measurement,for
R983	T1651	T1645	prep	in,used
R984	T1652	T1653	det	these,studies
R985	T1653	T1651	pobj	studies,in
R986	T1654	T1645	punct	.,used
R987	T1656	T1657	prep	With,included
R988	T1658	T1659	compound	StaRT,PCR
R991	T1661	T1657	punct	", ",included
R992	T1662	T1663	det	an,standard
R995	T1665	T1663	prep	for,standard
R996	T1666	T1667	det	each,gene
R997	T1667	T1665	pobj	gene,for
R998	T1668	T1663	prep	within,standard
R999	T1669	T1670	det	a,mixture
R1002	T1672	T1670	prep	of,mixture
R1003	T1673	T1674	amod	internal,standards
R1004	T1674	T1672	pobj	standards,of
R1005	T1675	T1670	punct	(,mixture
R1006	T1676	T1670	appos	SMIS,mixture
R1007	T1677	T1657	punct	),included
R1008	T1678	T1657	auxpass	is,included
R1009	T1679	T1657	prep	in,included
R1010	T1680	T1681	det	each,reaction
R1013	T1683	T1657	punct	.,included
R1014	T1685	T1686	prep	After,electrophoresed
R1015	T1687	T1685	pobj	amplification,After
R1016	T1688	T1686	punct	", ",electrophoresed
R1017	T1689	T1686	nsubjpass	products,electrophoresed
R1018	T1690	T1686	auxpass	were,electrophoresed
R1019	T1691	T1686	prep	on,electrophoresed
R1020	T1692	T1693	det	an,Bioanalyzer
R1024	T1696	T1686	advcl	using,electrophoresed
R1025	T1697	T1698	compound	DNA,Chips
R1026	T1698	T1696	dobj	Chips,using
R1027	T1699	T1696	prep	with,using
R1028	T1700	T1701	nmod	DNA,Kit
R1031	T1703	T1699	pobj	reagents,with
R1032	T1704	T1696	prep	for,using
R1033	T1705	T1704	pobj	visualization,for
R1034	T1706	T1696	prep	according,using
R1035	T1707	T1706	prep	to,according
R1036	T1708	T1709	det	the,manufacturer
R1037	T1709	T1710	poss	manufacturer,protocol
R1040	T1712	T1713	punct	(,GmbH
R1045	T1717	T1713	punct	", ",GmbH
R1046	T1718	T1713	npadvmod	Waldbronn,GmbH
R1047	T1719	T1713	punct	", ",GmbH
R1048	T1720	T1713	npadvmod	Germany,GmbH
R1049	T1721	T1713	punct	),GmbH
R1050	T1722	T1686	punct	.,electrophoresed
R1051	T1724	T1725	det	The,technology
R1054	T1727	T1725	compound	PCR,technology
R1056	T1730	T1729	auxpass	is,licensed
R1057	T1731	T1729	prep	to,licensed
R1058	T1732	T1733	compound	Gene,Express
R1059	T1733	T1731	pobj	Express,to
R1060	T1734	T1733	punct	", ",Express
R1061	T1735	T1733	amod	Inc.,Express
R1062	T1736	T1737	punct	(,Toledo
R1063	T1737	T1733	parataxis	Toledo,Express
R1064	T1738	T1737	punct	", ",Toledo
R1065	T1739	T1737	npadvmod	OH,Toledo
R1066	T1740	T1737	punct	),Toledo
R1067	T1741	T1729	punct	.,licensed
R1068	T1743	T1744	nsubj	Many,are
R1069	T1745	T1743	prep	of,Many
R1070	T1746	T1747	det	the,reagents
R1071	T1747	T1745	pobj	reagents,of
R1072	T1748	T1744	acomp	available,are
R1073	T1749	T1744	advmod	commercially,are
R1074	T1750	T1744	cc	and,are
R1075	T1751	T1752	auxpass	were,obtained
R1076	T1752	T1744	conj	obtained,are
R1077	T1753	T1752	prep	through,obtained
R1078	T1754	T1755	compound	Gene,Express
R1079	T1755	T1753	pobj	Express,through
R1080	T1756	T1755	punct	", ",Express
R1081	T1757	T1755	amod	Inc.,Express
R1082	T1758	T1752	prep	for,obtained
R1083	T1759	T1760	det	this,study
R1084	T1760	T1758	pobj	study,for
R1085	T1761	T1744	punct	.,are
R1086	T1763	T1764	compound	StaRT,PCR
R1089	T1766	T1767	nsubjpass	reagents,prepared
R1090	T1768	T1766	prep	for,reagents
R1091	T1769	T1768	pobj	each,for
R1092	T1770	T1769	prep	of,each
R1093	T1771	T1772	det	the,genes
R1096	T1774	T1775	dep	that,were
R1097	T1775	T1772	relcl	were,genes
R1098	T1776	T1775	neg	not,were
R1099	T1777	T1778	advmod	commercially,available
R1100	T1778	T1775	acomp	available,were
R1101	T1779	T1772	punct	", ",genes
R1102	T1780	T1772	prep	including,genes
R1103	T1781	T1780	pobj	primers,including
R1104	T1782	T1781	cc	and,primers
R1105	T1783	T1781	conj	SMIS,primers
R1106	T1784	T1767	punct	", ",prepared
R1107	T1785	T1767	auxpass	were,prepared
R1108	T1786	T1767	prep	according,prepared
R1109	T1787	T1786	prep	to,according
R1110	T1788	T1789	advmod	previously,described
R1111	T1789	T1790	amod	described,methods
R1112	T1790	T1787	pobj	methods,to
R1113	T1791	T1792	punct	[,12
R1117	T1795	T1792	punct	],12
R1118	T1796	T1767	punct	.,prepared
R1119	T1798	T1799	compound	Sequence,information
R1120	T1799	T1800	nsubjpass	information,provided
R1121	T1801	T1799	prep	for,information
R1122	T1802	T1803	det	the,primers
R1123	T1803	T1801	pobj	primers,for
R1124	T1804	T1800	auxpass	is,provided
R1125	T1805	T1800	prep	in,provided
R1126	T1806	T1805	pobj	Table,in
R1127	T1807	T1806	nummod	2,Table
R1128	T1808	T1800	punct	.,provided
R1129	T1810	T1811	csubj	Including,controls
R1130	T1812	T1813	det	an,standard
R1133	T1815	T1810	prep	within,Including
R1134	T1816	T1817	det	a,SMIS
R1135	T1817	T1815	pobj	SMIS,within
R1136	T1818	T1810	prep	in,Including
R1137	T1819	T1820	det	each,measurement
R1138	T1820	T1818	pobj	measurement,in
R1139	T1821	T1811	prep	for,controls
R1140	T1822	T1823	det	all,sources
R1143	T1825	T1823	prep	of,sources
R1144	T1826	T1825	pobj	variation,of
R1145	T1827	T1811	prep	during,controls
R1146	T1828	T1827	pobj	PCR,during
R1147	T1829	T1811	punct	", ",controls
R1148	T1830	T1811	prep	including,controls
R1149	T1831	T1830	pobj	inhibitors,including
R1150	T1832	T1831	prep	in,inhibitors
R1151	T1833	T1832	pobj	samples,in
R1152	T1834	T1811	punct	", ",controls
R1153	T1835	T1811	cc	and,controls
R1154	T1836	T1811	conj	generates,controls
R1155	T1837	T1838	advmod	virtually,multiplexed
R1161	T1843	T1844	dep	that,are
R1162	T1844	T1840	relcl	are,data
R1163	T1845	T1846	advmod	directly,comparable
R1164	T1846	T1844	acomp	comparable,are
R1165	T1847	T1844	prep	across,are
R1166	T1848	T1849	amod	multiple,experiments
R1167	T1849	T1847	pobj	experiments,across
R1168	T1850	T1849	cc	and,experiments
R1169	T1851	T1849	conj	institutions,experiments
R1170	T1852	T1853	punct	[,13
R1171	T1853	T1836	parataxis	13,generates
R1172	T1854	T1853	punct	],13
R1173	T1855	T1811	punct	.,controls
R1174	T1857	T1858	det	The,characteristics
R1177	T1861	T1858	prep	of,characteristics
R1178	T1862	T1863	compound	StaRT,PCR
R1181	T1865	T1860	acomp	superior,are
R1182	T1866	T1865	prep	to,superior
R1183	T1867	T1868	amod	other,forms
R1184	T1868	T1866	pobj	forms,to
R1185	T1869	T1868	prep	of,forms
R1186	T1870	T1871	advmod	commercially,available
R1187	T1871	T1872	amod	available,technology
R1191	T1875	T1860	prep	in,are
R1192	T1876	T1877	det	the,areas
R1193	T1877	T1875	pobj	areas,in
R1194	T1878	T1877	amod	critical,areas
R1195	T1879	T1878	prep	to,critical
R1196	T1880	T1881	det	this,study
R1197	T1881	T1879	pobj	study,to
R1198	T1882	T1860	punct	.,are
R1199	T1884	T1885	prep	With,is
R1200	T1886	T1884	pobj	respect,With
R1201	T1887	T1886	prep	to,respect
R1202	T1888	T1889	det	these,studies
R1203	T1889	T1887	pobj	studies,to
R1204	T1890	T1885	punct	", ",is
R1205	T1891	T1892	det	the,property
R1208	T1894	T1892	prep	of,property
R1209	T1895	T1896	det	a,method
R1213	T1899	T1885	neg	not,is
R1214	T1900	T1901	mark	whether,measured
R1217	T1903	T1901	nsubjpass	products,measured
R1220	T1906	T1907	advmod	kinetically,at
R1223	T1909	T1907	pobj	endpoint,at
R1224	T1910	T1901	punct	", ",measured
R1225	T1911	T1901	cc	but,measured
R1226	T1912	T1911	advmod	rather,but
R1227	T1913	T1914	mark	whether,are
R1230	T1916	T1917	amod	internal,standards
R1231	T1917	T1914	attr	standards,are
R1232	T1918	T1914	prep	in,are
R1233	T1919	T1920	det	each,measurement
R1234	T1920	T1918	pobj	measurement,in
R1235	T1921	T1914	cc	or,are
R1236	T1922	T1914	conj	not,are
R1237	T1923	T1885	punct	.,is
R1238	T1925	T1926	det	The,characteristics
R1242	T1930	T1926	prep	of,characteristics
R1243	T1931	T1932	compound	StaRT,PCR
R1246	T1934	T1926	punct	", ",characteristics
R1247	T1935	T1926	prep	including,characteristics
R1248	T1936	T1937	amod	extensive,validation
R1249	T1937	T1935	pobj	validation,including
R1250	T1938	T1937	prep	of,validation
R1251	T1939	T1940	det	the,method
R1252	T1940	T1938	pobj	method,of
R1253	T1941	T1937	prep	in,validation
R1254	T1942	T1943	amod	independent,laboratories
R1255	T1943	T1941	pobj	laboratories,in
R1256	T1944	T1929	aux	have,presented
R1257	T1945	T1929	auxpass	been,presented
R1258	T1946	T1929	prep	in,presented
R1259	T1947	T1948	amod	several,articles
R1262	T1950	T1948	cc	and,articles
R1263	T1951	T1948	conj	chapters,articles
R1264	T1952	T1953	punct	[,13
R1265	T1953	T1929	parataxis	13,presented
R1266	T1954	T1955	punct	-,15
R1267	T1955	T1953	prep	15,13
R1268	T1956	T1953	punct	],13
R1269	T1957	T1929	punct	.,presented
R1270	T1959	T1960	prep	With,had
R1271	T1961	T1959	pobj	respect,With
R1272	T1962	T1961	prep	to,respect
R1273	T1963	T1964	det	the,genes
R1274	T1964	T1962	pobj	genes,to
R1275	T1965	T1964	acl	measured,genes
R1276	T1966	T1965	prep	in,measured
R1277	T1967	T1968	det	this,study
R1278	T1968	T1966	pobj	study,in
R1279	T1969	T1960	punct	", ",had
R1280	T1970	T1960	prep	for,had
R1281	T1971	T1972	det	each,gene
R1282	T1972	T1970	pobj	gene,for
R1283	T1973	T1974	det	the,reagents
R1286	T1976	T1974	compound	PCR,reagents
R1288	T1978	T1979	amod	lower,threshold
R1291	T1981	T1979	prep	of,threshold
R1292	T1982	T1983	amod	less,10
R1295	T1985	T1981	pobj	molecules,of
R1296	T1986	T1979	punct	", ",threshold
R1297	T1987	T1988	amod	linear,range
R1300	T1990	T1988	prep	of,range
R1301	T1991	T1992	amod	more,six
R1304	T1994	T1990	pobj	orders,of
R1305	T1995	T1994	prep	of,orders
R1306	T1996	T1995	pobj	magnitude,of
R1307	T1997	T1998	punct	(,10
R1311	T2001	T1998	prep	to,10
R1312	T2002	T2003	quantmod	over,107
R1313	T2003	T2004	nummod	107,molecules
R1314	T2004	T2001	pobj	molecules,to
R1315	T2005	T1998	punct	),10
R1316	T2006	T1988	punct	", ",range
R1317	T2007	T1988	cc	and,range
R1318	T2008	T2009	nmod	signal,response
R1324	T2014	T2009	prep	of,response
R1325	T2015	T2016	nummod	100,%
R1326	T2016	T2014	pobj	%,of
R1327	T2017	T1960	punct	.,had
R1328	T2019	T2020	prep	In,controls
R1329	T2021	T2019	pobj	addition,In
R1330	T2022	T2020	punct	", ",controls
R1331	T2023	T2024	det	the,presence
R1332	T2024	T2020	nsubj	presence,controls
R1333	T2025	T2024	prep	of,presence
R1334	T2026	T2027	det	an,standard
R1337	T2029	T2020	prep	for,controls
R1338	T2030	T2031	amod	inter-sample,variation
R1339	T2031	T2029	pobj	variation,for
R1340	T2032	T2020	prep	in,controls
R1341	T2033	T2032	pobj	presence,in
R1342	T2034	T2033	prep	of,presence
R1343	T2035	T2036	compound	PCR,inhibitors
R1344	T2036	T2034	pobj	inhibitors,of
R1345	T2037	T2036	punct	(,inhibitors
R1346	T2038	T2039	dep	which,are
R1349	T2041	T2042	npadvmod	gene,specific
R1352	T2044	T2020	punct	),controls
R1353	T2045	T2020	cc	and,controls
R1354	T2046	T2020	conj	ensures,controls
R1355	T2047	T2048	det	no,negatives
R1358	T2050	T2051	punct	(,observed
R1371	T2063	T2051	cc	and,observed
R1372	T2064	T2065	expl	there,are
R1373	T2065	T2051	conj	are,observed
R1374	T2066	T2067	det	no,data
R1375	T2067	T2065	attr	data,are
R1376	T2068	T2069	aux	to,report
R1377	T2069	T2067	advcl	report,data
R1378	T2070	T2051	punct	),observed
R1379	T2071	T2020	punct	.,controls
R1380	T2073	T2074	amod	False,positives
R1381	T2074	T2075	nsubjpass	positives,eliminated
R1382	T2076	T2075	auxpass	are,eliminated
R1383	T2077	T2075	prep	through,eliminated
R1384	T2078	T2077	pobj	use,through
R1385	T2079	T2078	prep	of,use
R1386	T2080	T2081	det	a,reaction
R1390	T2084	T2081	prep	with,reaction
R1391	T2085	T2086	det	no,cDNA
R1392	T2086	T2084	pobj	cDNA,with
R1393	T2087	T2086	prep	in,cDNA
R1394	T2088	T2087	pobj	it,in
R1395	T2089	T2075	punct	.,eliminated
R2392	T4273	T4271	pobj	values,with
R2497	T4386	T4384	pobj	site,to
R2582	T4475	T4473	pobj	database,in
R2811	T4724	T4721	pobj	smokers,Among
R2902	T4820	T4823	advcl	is,be
R3005	T4930	T4928	pobj	members,with
R3060	T4987	T4985	pobj	regulator,as
R3096	T5025	T5029	compound	knockout,mice
R3361	T5311	T5312	advmod	far,met
R3594	T5559	T5558	punct	", ",GSTP1
R3595	T5560	T5558	conj	SOD1,GSTP1
R3596	T5561	T5560	punct	", ",SOD1
R3682	T5733	T5720	punct	.,are
R3683	T5735	T5736	nsubj	Correlation,is
R3685	T5737	T5735	prep	at,Correlation
R3686	T5738	T5739	det	the,level
R3688	T5739	T5737	pobj	level,at
R3689	T5740	T5741	compound	transcript,abundance
R3690	T5741	T5739	compound	abundance,level
R3691	T5742	T5743	det	an,property
R3693	T5743	T5736	attr	property,is
R3695	T5744	T5743	amod	important,property
R3696	T5745	T5743	prep	of,property
R3697	T5746	T5745	pobj	genes,of
R3698	T5747	T5748	dep	that,co-regulated
R3700	T5748	T5746	relcl	co-regulated,genes
R3701	T5749	T5748	auxpass	are,co-regulated
R3703	T5750	T5748	prep	at,co-regulated
R3704	T5751	T5752	det	the,level
R3705	T5752	T5750	pobj	level,at
R3706	T5753	T5752	compound	transcription,level
R3707	T5754	T5736	punct	.,is

2_test

Id	Subject	Object	Predicate	Lexical cue
16255782-14705493-8759910	2698-2699	14705493	denotes	1
16255782-16088748-8759910	2698-2699	16088748	denotes	1
16255782-8242618-8759911	3000-3001	8242618	denotes	4
16255782-1339300-8759911	3000-3001	1339300	denotes	4
16255782-1486868-8759911	3000-3001	1486868	denotes	4
16255782-8242618-8759912	3166-3167	8242618	denotes	4
16255782-1339300-8759912	3166-3167	1339300	denotes	4
16255782-1486868-8759912	3166-3167	1486868	denotes	4
16255782-6290784-8759912	3166-3167	6290784	denotes	4
16255782-6290784-8759913	3421-3422	6290784	denotes	7
16255782-8533150-8759914	3599-3600	8533150	denotes	8
16255782-10749130-8759915	3859-3860	10749130	denotes	9
16255782-10891549-8759916	4296-4298	10891549	denotes	10
16255782-10749130-8759917	5123-5124	10749130	denotes	9
16255782-12054630-8759918	5125-5127	12054630	denotes	11
16255782-10749130-8759919	5935-5936	10749130	denotes	9
16255782-12054630-8759920	5937-5939	12054630	denotes	11
16255782-12054630-8759921	6778-6780	12054630	denotes	11
16255782-14970455-8759922	7138-7140	14970455	denotes	13
16255782-14970455-8759923	7721-7723	14970455	denotes	13
16255782-14970455-8759923	7721-7723	14970455	denotes	13
16255782-8532532-8759924	10327-10329	8532532	denotes	18
16255782-7501458-8759925	17673-17675	7501458	denotes	20
16255782-12177065-8759926	17780-17782	12177065	denotes	21
16255782-7501458-8759927	17798-17800	7501458	denotes	20
16255782-12177065-8759928	17929-17931	12177065	denotes	21
16255782-7501458-8759929	18035-18037	7501458	denotes	20
16255782-11799067-8759930	19337-19339	11799067	denotes	24
16255782-15735727-8759931	19340-19342	15735727	denotes	25
16255782-12496041-8759932	19764-19766	12496041	denotes	26
16255782-15177551-8759933	20451-20453	15177551	denotes	27

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T97	0-5	PR_EXT:000005311	denotes	CEBPG
T98	6-19	GO_EXT:transcription	denotes	transcription
T99	6-26	GO_EXT:transcription_factor	denotes	transcription factor
T100	43-54	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T101	47-54	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T102	59-62	CHEBI_SO_EXT:DNA	denotes	DNA
T103	59-69	GO:0006281	denotes	DNA repair
T104	70-75	SO_EXT:0000704	denotes	genes
T105	86-106	UBERON:0002031	denotes	bronchial epithelial
T106	86-112	CL:0002328	denotes	bronchial epithelial cells
T107	107-112	CL_GO_EXT:cell	denotes	cells
T108	124-135	NCBITaxon:1	denotes	individuals
T109	358-369	SO_EXT:0000704	denotes	genetically
T110	414-425	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T111	418-425	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T112	426-431	SO_EXT:0000704	denotes	genes
T113	442-452	SO_EXT:0000673	denotes	transcript
T114	483-503	UBERON:0002031	denotes	bronchial epithelial
T115	483-509	CL:0002328	denotes	bronchial epithelial cells
T116	504-509	CL_GO_EXT:cell	denotes	cells
T117	523-534	NCBITaxon:1	denotes	individuals
T118	554-565	NCBITaxon:1	denotes	individuals
T119	616-626	SO_EXT:0000673	denotes	transcript
T120	656-659	CHEBI_SO_EXT:DNA	denotes	DNA
T121	656-666	GO:0006281	denotes	DNA repair
T122	667-672	SO_EXT:0000704	denotes	genes
T123	700-711	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T124	704-711	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T125	712-717	SO_EXT:0000704	denotes	genes
T126	757-768	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T127	761-768	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T128	773-776	CHEBI_SO_EXT:DNA	denotes	DNA
T129	773-783	GO:0006281	denotes	DNA repair
T130	784-789	SO_EXT:0000704	denotes	genes
T131	797-806	GO:0065007	denotes	regulated
T132	822-835	GO_EXT:transcription	denotes	transcription
T133	822-843	GO_EXT:transcription_factor	denotes	transcription factors
T134	859-869	NCBITaxon:1	denotes	individual
T135	883-893	GO:0010467	denotes	expression
T136	934-947	GO_EXT:transcription	denotes	transcription
T137	934-955	GO_EXT:transcription_factor	denotes	transcription factors
T138	981-991	NCBITaxon:1	denotes	individual
T139	1040-1053	GO_EXT:transcription	denotes	transcription
T140	1040-1060	GO_EXT:transcription_factor	denotes	transcription factor
T141	1040-1078	SO_EXT:0000235	denotes	transcription factor recognition sites
T142	1100-1111	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T143	1104-1111	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T144	1112-1117	SO_EXT:0000704	denotes	genes
T145	1152-1155	CHEBI_SO_EXT:DNA	denotes	DNA
T146	1156-1164	SO_EXT:biological_sequence	denotes	sequence
T147	1179-1189	SO_EXT:0000673	denotes	transcript
T148	1216-1229	GO_EXT:transcription	denotes	transcription
T149	1216-1237	GO_EXT:transcription_factor	denotes	transcription factors
T150	1271-1282	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T151	1275-1282	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T152	1287-1290	CHEBI_SO_EXT:DNA	denotes	DNA
T153	1287-1297	GO:0006281	denotes	DNA repair
T154	1298-1303	SO_EXT:0000704	denotes	genes
T155	1393-1404	NCBITaxon:1	denotes	individuals
T156	1415-1420	PR_EXT:000005311	denotes	CEBPG
T157	1421-1434	GO_EXT:transcription	denotes	transcription
T158	1421-1441	GO_EXT:transcription_factor	denotes	transcription factor
T159	1500-1511	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T160	1504-1511	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T161	1515-1518	CHEBI_SO_EXT:DNA	denotes	DNA
T162	1515-1525	GO:0006281	denotes	DNA repair
T163	1526-1531	SO_EXT:0000704	denotes	genes
T164	1542-1553	NCBITaxon:1	denotes	individuals
T165	1568-1579	NCBITaxon:1	denotes	individuals
T166	1587-1598	NCBITaxon:1	denotes	individuals
T167	1620-1625	PR_EXT:000005311	denotes	CEBPG
T168	1681-1692	NCBITaxon:1	denotes	individuals
T169	1709-1714	SO_EXT:0000704	denotes	genes
T170	1716-1721	PR_EXT:000017504	denotes	XRCC1
T171	1723-1728	PR_EXT:000007167	denotes	ERCC5
T172	1730-1735	PR_EXT:000029950	denotes	GSTP1
T173	1741-1745	PR_EXT:000015399	denotes	SOD1
T174	1793-1797	PR_EXT:000008210	denotes	GPX1
T175	1814-1827	GO_EXT:transcription	denotes	transcription
T176	1814-1834	GO_EXT:transcription_factor	denotes	transcription factor
T177	1876-1881	SO_EXT:0000704	denotes	genes
T178	1892-1903	NCBITaxon:1	denotes	individuals
T179	1908-1912	PR_EXT:000006852	denotes	E2F1
T180	1914-1918	PR_EXT:000006852	denotes	E2F1
T181	1939-1944	PR_EXT:000029950	denotes	GSTP1
T182	1958-1969	NCBITaxon:1	denotes	individuals
T183	1990-1995	PR_EXT:000005311	denotes	CEBPG
T184	2063-2074	NCBITaxon:1	denotes	individuals
T185	2090-2101	NCBITaxon:1	denotes	individuals
T186	2132-2137	PR_EXT:000005311	denotes	CEBPG
T187	2145-2158	GO_EXT:transcription	denotes	transcription
T188	2145-2165	GO_EXT:transcription_factor	denotes	transcription factor
T189	2192-2202	GO:0065007	denotes	regulating
T190	2203-2216	GO_EXT:transcription	denotes	transcription
T191	2224-2235	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T192	2228-2235	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T193	2240-2243	CHEBI_SO_EXT:DNA	denotes	DNA
T194	2240-2250	GO:0006281	denotes	DNA repair
T195	2251-2256	SO_EXT:0000704	denotes	genes
T196	2267-2278	NCBITaxon:1	denotes	individuals
T197	2386-2396	GO:0065007	denotes	regulation
T198	2400-2411	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T199	2404-2411	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T200	2416-2419	CHEBI_SO_EXT:DNA	denotes	DNA
T201	2416-2426	GO:0006281	denotes	DNA repair
T202	2427-2432	SO_EXT:0000704	denotes	genes
T203	2436-2441	PR_EXT:000005311	denotes	CEBPG
T774	2507-2512	GO:0016265	denotes	death
T775	2561-2567	GO:0016265	denotes	deaths
T776	2704-2715	CHEBI_GO_EXT:antioxidant	denotes	Antioxidant
T777	2708-2715	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T778	2720-2723	CHEBI_SO_EXT:DNA	denotes	DNA
T779	2720-2730	GO:0006281	denotes	DNA repair
T780	2731-2738	CHEBI_GO_SO_EXT:enzyme	denotes	enzymes
T781	2803-2812	GO:0010467	denotes	expressed
T782	2831-2836	CL_GO_EXT:cell	denotes	cells
T783	2852-2872	UBERON:0002031	denotes	bronchial epithelial
T784	2852-2878	CL:0002328	denotes	bronchial epithelial cells
T785	2873-2878	CL_GO_EXT:cell	denotes	cells
T786	2907-2917	NCBITaxon:1	denotes	individual
T787	2953-2958	SO_EXT:0000704	denotes	genes
T788	3006-3017	CHEBI_GO_EXT:antioxidant	denotes	Antioxidant
T789	3010-3017	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T790	3018-3025	CHEBI_GO_SO_EXT:enzyme	denotes	enzymes
T791	3044-3067	CHEBI:26523	denotes	reactive oxygen species
T792	3101-3126	GO:0006805	denotes	metabolism of xenobiotics
T793	3115-3126	CHEBI_EXT:35703	denotes	xenobiotics
T794	3207-3215	CL_GO_EXT:cell	denotes	cellular
T795	3207-3226	GO:0044237	denotes	cellular metabolism
T796	3228-3251	CHEBI:26523	denotes	Reactive oxygen species
T797	3292-3316	GO:0030164	denotes	denaturation of proteins
T798	3308-3316	CHEBI_PR_EXT:protein	denotes	proteins
T799	3324-3331	SO_EXT:sequence_fusion_process	denotes	linking
T800	3335-3341	CHEBI:18059	denotes	lipids
T801	3346-3354	CHEBI_PR_EXT:protein	denotes	proteins
T802	3359-3371	SO_EXT:sequence_alteration_entity_or_process	denotes	modification
T803	3375-3382	GO:0005634	denotes	nucleic
T804	3375-3393	CHEBI_SO_EXT:base	denotes	nucleic acid bases
T805	3425-3428	CHEBI_SO_EXT:DNA	denotes	DNA
T806	3425-3435	GO:0006281	denotes	DNA repair
T807	3436-3443	CHEBI_GO_SO_EXT:enzyme	denotes	enzymes
T808	3444-3450	GO:0006281	denotes	repair
T809	3474-3477	CHEBI_SO_EXT:DNA	denotes	DNA
T810	3488-3495	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T811	3567-3578	CHEBI_EXT:50903	denotes	carcinogens
T812	3646-3656	SO_EXT:0000673	denotes	transcript
T813	3684-3695	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T814	3688-3695	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T815	3696-3701	SO_EXT:0000704	denotes	genes
T816	3726-3737	NCBITaxon:1	denotes	individuals
T817	3757-3768	NCBITaxon:1	denotes	individuals
T818	3789-3800	NCBITaxon:1	denotes	individuals
T819	3835-3846	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T820	3839-3846	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T821	3922-3932	SO_EXT:0000673	denotes	transcript
T822	3968-3979	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T823	3972-3979	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T824	3983-3986	CHEBI_SO_EXT:DNA	denotes	DNA
T825	3983-3993	GO:0006281	denotes	DNA repair
T826	3994-3999	SO_EXT:0000704	denotes	genes
T827	4010-4021	NCBITaxon:1	denotes	individuals
T828	4037-4048	NCBITaxon:1	denotes	individuals
T829	4050-4054	SO_EXT:0000704	denotes	Gene
T830	4095-4100	PR_EXT:000029950	denotes	GSTP1
T831	4101-4105	PR_EXT:000008210	denotes	GPX1
T832	4107-4110	GO_PR_EXT:catalase	denotes	CAT
T833	4111-4115	PR_EXT:000008212	denotes	GPX3
T834	4121-4125	PR_EXT:000008212	denotes	GPX3
T835	4126-4130	PR_EXT:000015399	denotes	SOD1
T836	4180-4189	GO:0065007	denotes	regulated
T837	4190-4195	SO_EXT:0000704	denotes	genes
T838	4215-4228	GO_EXT:transcription	denotes	transcription
T839	4215-4235	GO_EXT:transcription_factor	denotes	transcription factor
T840	4215-4253	SO_EXT:0000235	denotes	transcription factor recognition sites
T841	4261-4271	GO:0065007	denotes	regulatory
T842	4261-4279	SO_EXT:0005836	denotes	regulatory regions
T843	4289-4294	SO_EXT:0000704	denotes	genes
T844	4377-4387	NCBITaxon:1	denotes	individual
T845	4401-4411	GO:0065007	denotes	regulation
T846	4419-4430	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T847	4423-4430	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T848	4435-4438	CHEBI_SO_EXT:DNA	denotes	DNA
T849	4435-4445	GO:0006281	denotes	DNA repair
T850	4446-4451	SO_EXT:0000704	denotes	genes
T851	4467-4480	GO_EXT:transcription	denotes	transcription
T852	4467-4488	GO_EXT:transcription_factor	denotes	transcription factors
T853	4506-4517	NCBITaxon:1	denotes	individuals
T854	4535-4545	GO:0065007	denotes	regulation
T855	4633-4646	GO_EXT:transcription	denotes	transcription
T856	4633-4653	GO_EXT:transcription_factor	denotes	transcription factor
T857	4633-4671	SO_EXT:0000235	denotes	transcription factor recognition sites
T858	4686-4696	GO:0065007	denotes	regulatory
T859	4686-4704	SO_EXT:0005836	denotes	regulatory regions
T860	4729-4733	SO_EXT:0000704	denotes	gene
T861	4774-4777	CHEBI_SO_EXT:DNA	denotes	DNA
T862	4778-4786	SO_EXT:biological_sequence	denotes	sequence
T863	4807-4817	SO_EXT:0000673	denotes	transcript
T864	4882-4893	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T865	4886-4893	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T866	4902-4905	CHEBI_SO_EXT:DNA	denotes	DNA
T867	4902-4912	GO:0006281	denotes	DNA repair
T868	4913-4918	SO_EXT:0000704	denotes	genes
T1376	4985-5005	UBERON:0002031	denotes	bronchial epithelium
T1377	5137-5157	UBERON:0002031	denotes	bronchial epithelium
T1378	5165-5169	UBERON:0002048	denotes	lung
T1379	5580-5591	NCBITaxon:1	denotes	individuals
T1380	5613-5624	NCBITaxon:1	denotes	individuals
T1381	5635-5646	NCBITaxon:1	denotes	individuals
T1382	5720-5731	NCBITaxon:1	denotes	individuals
T1545	5759-5769	SO_EXT:0000673	denotes	Transcript
T1546	5798-5801	CHEBI_SO_EXT:RNA	denotes	RNA
T1547	5835-5854	GO:0001171	denotes	reverse transcribed
T1548	5861-5866	NCBITaxon:11801	denotes	M-MLV
T1549	5867-5888	GO_EXT:0003964	denotes	reverse transcriptase
T1550	5893-5898	CHEBI_SO_EXT:oligonucleotide	denotes	oligo
T1551	5899-5901	CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group	denotes	dT
T1552	5902-5909	SO_EXT:0000112	denotes	primers
T1553	5955-5957	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T1554	5983-5993	SO_EXT:0000673	denotes	transcript
T1555	6080-6084	SO_EXT:0000704	denotes	gene
T1556	6266-6269	CHEBI_SO_EXT:DNA	denotes	DNA
T1557	6281-6284	CHEBI_SO_EXT:DNA	denotes	DNA
T1558	6294-6302	CHEBI_EXT:33893	denotes	reagents
T1559	6463-6467	SO_EXT:0000704	denotes	Gene
T1560	6508-6516	CHEBI_EXT:33893	denotes	reagents
T1561	6570-6574	SO_EXT:0000704	denotes	Gene
T1562	6615-6623	CHEBI_EXT:33893	denotes	reagents
T1563	6649-6654	SO_EXT:0000704	denotes	genes
T1564	6703-6710	SO_EXT:0000112	denotes	primers
T1565	6786-6794	SO_EXT:biological_sequence	denotes	Sequence
T1566	6815-6822	SO_EXT:0000112	denotes	primers
T1567	6978-6988	CHEBI_EXT:35222	denotes	inhibitors
T1568	7037-7047	SO_EXT:0000673	denotes	transcript
T1569	7403-7415	SO_EXT:0000006	denotes	PCR products
T1570	7749-7754	SO_EXT:0000704	denotes	genes
T1571	7788-7792	SO_EXT:0000704	denotes	gene
T1572	7807-7815	CHEBI_EXT:33893	denotes	reagents
T1573	7862-7871	CHEBI:36357	denotes	molecules
T1574	7957-7966	CHEBI:36357	denotes	molecules
T1575	7991-7999	GO_EXT:reaction_or_response	denotes	response
T1576	8114-8124	CHEBI_EXT:35222	denotes	inhibitors
T1577	8142-8146	SO_EXT:0000704	denotes	gene
T1578	8228-8239	SO_EXT:0000006	denotes	PCR product
T1579	8367-8371	SO_EXT:cDNA	denotes	cDNA
T2116	8417-8427	SO_EXT:0000673	denotes	transcript
T2117	8523-8536	GO_EXT:transcription	denotes	transcription
T2118	8523-8544	GO_EXT:transcription_factor	denotes	transcription factors
T2119	8557-8568	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T2120	8561-8568	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T2121	8573-8576	CHEBI_SO_EXT:DNA	denotes	DNA
T2122	8573-8583	GO:0006281	denotes	DNA repair
T2123	8584-8589	SO_EXT:0000704	denotes	genes
T2124	8614-8625	NCBITaxon:1	denotes	individuals
T2125	8637-8648	NCBITaxon:1	denotes	individuals
T2126	8659-8670	NCBITaxon:1	denotes	individuals
T2127	8704-8717	GO_EXT:transcription	denotes	transcription
T2128	8704-8725	GO_EXT:transcription_factor	denotes	transcription factors
T2129	8743-8754	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T2130	8747-8754	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T2131	8758-8761	CHEBI_SO_EXT:DNA	denotes	DNA
T2132	8758-8768	GO:0006281	denotes	DNA repair
T2133	8769-8774	SO_EXT:0000704	denotes	genes
T2134	8902-8912	CHEBI_GO_EXT:biological_process_or_quality_or_role	denotes	biological
T2135	8926-8936	GO:0010467	denotes	expression
T2136	8945-8949	SO_EXT:0000704	denotes	gene
T2137	8960-8971	NCBITaxon:1	denotes	individuals
T2138	9112-9125	GO_EXT:transcription	denotes	transcription
T2139	9112-9133	GO_EXT:transcription_factor	denotes	transcription factors
T2140	9149-9160	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T2141	9153-9160	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T2142	9164-9167	CHEBI_SO_EXT:DNA	denotes	DNA
T2143	9164-9174	GO:0006281	denotes	DNA repair
T2144	9175-9180	SO_EXT:0000704	denotes	genes
T2145	9371-9381	SO_EXT:0000673	denotes	transcript
T2146	9406-9410	SO_EXT:0000704	denotes	gene
T2395	9544-9557	GO_EXT:transcription	denotes	Transcription
T2396	9544-9564	GO_EXT:transcription_factor	denotes	Transcription factor
T2397	9544-9581	SO_EXT:0000235	denotes	Transcription factor recognition site
T2398	9694-9699	SO_EXT:0000704	denotes	genes
T2399	9711-9717	SO_EXT:0001026	denotes	genome
T2400	9734-9738	CHEBI_SO_EXT:base	denotes	base
T2401	9734-9744	SO_EXT:0000028	denotes	base pairs
T2402	9752-9760	SO_EXT:0000167	denotes	promoter
T2403	9775-9779	CHEBI_SO_EXT:base	denotes	base
T2404	9775-9785	SO_EXT:0000028	denotes	base pairs
T2405	9786-9794	SO_EXT:sequence_upstreamness	denotes	upstream
T2406	9806-9810	CHEBI_SO_EXT:base	denotes	base
T2407	9806-9816	SO_EXT:0000028	denotes	base pairs
T2408	9826-9839	GO_EXT:transcription	denotes	transcription
T2409	9826-9850	SO_EXT:0000315	denotes	transcription start site
T2410	9861-9865	SO_EXT:0000704	denotes	gene
T2411	9925-9929	CHEBI_SO_EXT:base	denotes	base
T2412	9925-9934	SO_EXT:0000028	denotes	base pair
T2413	9935-9944	SO_EXT:biological_sequence	denotes	sequences
T2414	10010-10019	SO_EXT:biological_sequence	denotes	sequences
T2415	10033-10046	GO_EXT:transcription	denotes	transcription
T2416	10033-10053	GO_EXT:transcription_factor	denotes	transcription factor
T2417	10033-10070	SO_EXT:0000235	denotes	transcription factor recognition site
T2418	10144-10153	_FRAGMENT	denotes	sites for
T2419	10157-10178	SO_EXT:0000235	denotes	transcription factors
T2420	10157-10170	GO_EXT:transcription	denotes	transcription
T2421	10157-10178	GO_EXT:transcription_factor	denotes	transcription factors
T2422	10342-10350	CHEBI_EXT:33893	denotes	reagents
T2423	10383-10396	GO_EXT:transcription	denotes	transcription
T2424	10383-10404	GO_EXT:transcription_factor	denotes	transcription factors
T2425	10416-10421	PR_EXT:000005308	denotes	CEBPB
T2426	10423-10428	PR_EXT:000005310	denotes	CEBPE
T2427	10430-10435	PR_EXT:000005311	denotes	CEBPG
T2428	10437-10441	PR_EXT:000006852	denotes	E2F1
T2429	10443-10447	PR_EXT:000006854	denotes	E2F3
T2430	10449-10453	PR_EXT:000006855	denotes	E2F4
T2431	10455-10459	PR_EXT:000006856	denotes	E2F5
T2432	10461-10465	PR_EXT:000006857	denotes	E2F6
T2433	10467-10471	PR_EXT:000035849	denotes	EVI1
T2434	10477-10481	PR_EXT:000001903	denotes	PAX5
T2435	10488-10501	GO_EXT:transcription	denotes	transcription
T2436	10488-10509	GO_EXT:transcription_factor	denotes	transcription factors
T2437	10515-10524	GO:0010467	denotes	expressed
T2438	10644-10649	PR_EXT:000005308	denotes	CEBPB
T2439	10651-10656	PR_EXT:000005311	denotes	CEBPG
T2440	10658-10662	PR_EXT:000006852	denotes	E2F1
T2441	10664-10668	PR_EXT:000006854	denotes	E2F3
T2442	10670-10674	PR_EXT:000006857	denotes	E2F6
T2443	10680-10683	PR_EXT:000035849	denotes	EVI
T2444	10746-10757	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T2445	10750-10757	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T2446	10766-10769	CHEBI_SO_EXT:DNA	denotes	DNA
T2447	10766-10776	GO:0006281	denotes	DNA repair
T2448	10777-10782	SO_EXT:0000704	denotes	genes
T2726	7037-7047	SO_EXT:0000673	denotes	transcript
T2727	10864-10868	SO_EXT:0000704	denotes	gene
T2728	10907-10911	PR_EXT:000006852	denotes	E2F1
T2729	10951-10955	SO_EXT:0000704	denotes	gene
T2730	10965-10974	CHEBI_EXT:35222	denotes	inhibitor
T2731	11016-11020	PR_EXT:000006852	denotes	E2F1
T2732	11068-11072	SO_EXT:cDNA	denotes	cDNA
T2733	11073-11084	SO_EXT:0000006	denotes	PCR product
T2734	11115-11119	SO_EXT:0000704	denotes	gene
T2735	11231-11243	SO_EXT:0000006	denotes	PCR products
T2736	11306-11315	CHEBI:36357	denotes	molecules
T2941	11489-11500	NCBITaxon:1	denotes	individuals
T2942	11554-11559	PR_EXT:000005311	denotes	CEBPG
T2943	11580-11591	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T2944	11584-11591	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T2945	11595-11598	CHEBI_SO_EXT:DNA	denotes	DNA
T2946	11595-11605	GO:0006281	denotes	DNA repair
T2947	11606-11611	SO_EXT:0000704	denotes	genes
T2948	11626-11631	PR_EXT:000017504	denotes	XRCC1
T2949	11633-11638	PR_EXT:000007167	denotes	ERCC5
T2950	11640-11645	PR_EXT:000029950	denotes	GSTP1
T2951	11647-11651	PR_EXT:000015399	denotes	SOD1
T2952	11653-11657	PR_EXT:000008210	denotes	GPX1
T2953	11659-11664	PR_EXT:000007163	denotes	ERCC1
T2954	11666-11669	GO_PR_EXT:catalase	denotes	CAT
T2955	11674-11679	PR_EXT:000007164	denotes	ERCC2
T2956	11710-11721	NCBITaxon:1	denotes	individuals
T2957	11730-11735	PR_EXT:000005311	denotes	CEBPG
T2958	11771-11782	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T2959	11775-11782	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T2960	11786-11789	CHEBI_SO_EXT:DNA	denotes	DNA
T2961	11786-11796	GO:0006281	denotes	DNA repair
T2962	11797-11802	SO_EXT:0000704	denotes	genes
T2963	11864-11877	GO_EXT:transcription	denotes	transcription
T2964	11864-11885	GO_EXT:transcription_factor	denotes	transcription factors
T2965	11899-11904	PR_EXT:000017504	denotes	XRCC1
T2966	11906-11911	PR_EXT:000007167	denotes	ERCC5
T2967	11913-11918	PR_EXT:000029950	denotes	GSTP1
T2968	11924-11928	PR_EXT:000015399	denotes	SOD1
T2969	11950-11955	PR_EXT:000005311	denotes	CEBPG
T2970	11986-11997	NCBITaxon:1	denotes	individuals
T2971	12017-12028	NCBITaxon:1	denotes	individuals
T2972	12075-12079	PR_EXT:000008210	denotes	GPX1
T2973	12133-12138	PR_EXT:000005311	denotes	CEBPG
T2974	12143-12148	PR_EXT:000017504	denotes	XRCC1
T2975	12159-12170	NCBITaxon:1	denotes	individuals
T2976	12177-12188	NCBITaxon:1	denotes	individuals
T2977	12238-12243	SO_EXT:0000704	denotes	genes
T2978	12253-12258	PR_EXT:000005311	denotes	CEBPG
T2979	12264-12269	PR_EXT:000017504	denotes	XRCC1
T2980	12271-12276	PR_EXT:000007167	denotes	ERCC5
T2981	12278-12283	PR_EXT:000029950	denotes	GSTP1
T2982	12285-12289	PR_EXT:000015399	denotes	SOD1
T2983	12293-12297	PR_EXT:000008210	denotes	GPX1
T2984	12374-12385	NCBITaxon:1	denotes	individuals
T2985	12390-12401	NCBITaxon:1	denotes	individuals
T2986	12436-12447	NCBITaxon:1	denotes	individuals
T2987	12509-12514	PR_EXT:000005311	denotes	CEBPG
T2988	12552-12562	GO:0010467	denotes	expression
T2989	12566-12571	PR_EXT:000017504	denotes	XRCC1
T2990	12579-12584	PR_EXT:000007167	denotes	ERCC5
T2991	12592-12597	PR_EXT:000029950	denotes	GSTP1
T2992	12605-12609	PR_EXT:000015399	denotes	SOD1
T2993	12621-12625	PR_EXT:000008210	denotes	GPX1
T2994	12633-12637	PR_EXT:000006852	denotes	E2F1
T2995	12728-12739	NCBITaxon:1	denotes	individuals
T2996	12747-12758	NCBITaxon:1	denotes	individuals
T2997	12792-12796	PR_EXT:000006852	denotes	E2F1
T2998	12831-12836	PR_EXT:000007167	denotes	ERCC5
T2999	12838-12843	PR_EXT:000029950	denotes	GSTP1
T3000	12848-12852	PR_EXT:000015399	denotes	SOD1
T3001	12883-12894	NCBITaxon:1	denotes	individuals
T3002	12896-12900	PR_EXT:000006852	denotes	E2F1
T3003	12921-12926	PR_EXT:000029950	denotes	GSTP1
T3004	12973-12984	NCBITaxon:1	denotes	individuals
T3005	13040-13051	NCBITaxon:1	denotes	individuals
T3006	13059-13070	NCBITaxon:1	denotes	individuals
T3007	13110-13123	GO_EXT:transcription	denotes	transcription
T3008	13110-13131	GO_EXT:transcription_factor	denotes	transcription factors
T3009	13153-13158	PR_EXT:000017504	denotes	XRCC1
T3010	13160-13165	PR_EXT:000007167	denotes	ERCC5
T3011	13167-13172	PR_EXT:000029950	denotes	GSTP1
T3012	13174-13178	PR_EXT:000015399	denotes	SOD1
T3013	13183-13187	PR_EXT:000008210	denotes	GPX1
T3449	13220-13224	SO_EXT:0000704	denotes	gene
T3450	13220-13235	GO:0010467	denotes	gene expression
T3451	13269-13273	PR_EXT:000006852	denotes	E2F1
T3452	13278-13283	PR_EXT:000008307	denotes	GSTZ1
T3453	13326-13331	PR_EXT:000008300	denotes	GSTM1
T3454	13347-13351	SO_EXT:0000704	denotes	gene
T3455	13373-13383	GO:0010467	denotes	expression
T3456	13421-13426	PR_EXT:000007164	denotes	ERCC2
T3457	13427-13437	GO:0010467	denotes	expression
T3708	13552-13562	NCBITaxon:1	denotes	individual
T3709	13576-13586	GO:0065007	denotes	regulation
T3710	13594-13605	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3711	13598-13605	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3712	13610-13613	CHEBI_SO_EXT:DNA	denotes	DNA
T3713	13610-13620	GO:0006281	denotes	DNA repair
T3714	13621-13626	SO_EXT:0000704	denotes	genes
T3715	13642-13655	GO_EXT:transcription	denotes	transcription
T3716	13642-13663	GO_EXT:transcription_factor	denotes	transcription factors
T3717	13678-13689	NCBITaxon:1	denotes	individuals
T3718	13707-13717	GO:0065007	denotes	regulation
T3719	13856-13866	NCBITaxon:1	denotes	individual
T3720	13880-13890	SO_EXT:0000673	denotes	transcript
T3721	13901-13906	PR_EXT:000005311	denotes	CEBPG
T3722	13930-13935	SO_EXT:0000704	denotes	genes
T3723	13950-13961	NCBITaxon:1	denotes	individuals
T3724	13966-13971	PR_EXT:000005311	denotes	CEBPG
T3725	13972-13982	SO_EXT:0000673	denotes	transcript
T3726	14061-14071	SO_EXT:0000673	denotes	transcript
T3727	14101-14112	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3728	14105-14112	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3729	14117-14120	CHEBI_SO_EXT:DNA	denotes	DNA
T3730	14117-14127	GO:0006281	denotes	DNA repair
T3731	14128-14133	SO_EXT:0000704	denotes	genes
T3732	14144-14155	NCBITaxon:1	denotes	individuals
T3733	14202-14207	PR_EXT:000005311	denotes	CEBPG
T3734	14218-14223	SO_EXT:0000704	denotes	genes
T3735	14230-14241	NCBITaxon:1	denotes	individuals
T3736	14297-14308	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3737	14301-14308	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3738	14312-14315	CHEBI_SO_EXT:DNA	denotes	DNA
T3739	14312-14322	GO:0006281	denotes	DNA repair
T3740	14323-14328	SO_EXT:0000704	denotes	genes
T3741	14345-14350	PR_EXT:000005311	denotes	CEBPG
T3742	14361-14372	NCBITaxon:1	denotes	individuals
T3743	14376-14385	GO:0065007	denotes	regulated
T3744	14389-14394	PR_EXT:000005311	denotes	CEBPG
T3745	14440-14445	PR_EXT:000005311	denotes	CEBPG
T3746	14528-14541	GO_EXT:transcription	denotes	transcription
T3747	14528-14549	GO_EXT:transcription_factor	denotes	transcription factors
T3748	14576-14581	SO_EXT:0000704	denotes	genes
T3749	14643-14648	SO_EXT:0000704	denotes	genes
T3750	14654-14659	PR_EXT:000005308	denotes	CEBPB
T3751	14667-14672	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T3752	14685-14701	SO_EXT:0000409	denotes	recognition site
T3753	14705-14710	PR_EXT:000005311	denotes	CEBPG
T3754	14727-14743	SO_EXT:0000409	denotes	recognition site
T3755	14763-14774	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3756	14767-14774	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3757	14778-14781	CHEBI_SO_EXT:DNA	denotes	DNA
T3758	14778-14788	GO:0006281	denotes	DNA repair
T3759	14789-14794	SO_EXT:0000704	denotes	genes
T3760	14872-14877	PR_EXT:000005311	denotes	CEBPG
T3761	14883-14894	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3762	14887-14894	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3763	14899-14902	CHEBI_SO_EXT:DNA	denotes	DNA
T3764	14899-14909	GO:0006281	denotes	DNA repair
T3765	14910-14915	SO_EXT:0000704	denotes	genes
T3766	14926-14937	NCBITaxon:1	denotes	individuals
T3767	14963-14968	PR_EXT:000005311	denotes	CEBPG
T3768	14996-15007	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3769	15000-15007	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3770	15011-15014	CHEBI_SO_EXT:DNA	denotes	DNA
T3771	15011-15021	GO:0006281	denotes	DNA repair
T3772	15022-15027	SO_EXT:0000704	denotes	genes
T3773	15031-15040	GO:0065007	denotes	regulated
T3774	15046-15059	GO_EXT:transcription	denotes	transcription
T3775	15046-15066	GO_EXT:transcription_factor	denotes	transcription factor
T3776	15109-15125	SO_EXT:0000409	denotes	recognition site
T3777	15290-15295	PR_EXT:000005311	denotes	CEBPG
T3778	15300-15311	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3779	15304-15311	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3780	15315-15318	CHEBI_SO_EXT:DNA	denotes	DNA
T3781	15315-15325	GO:0006281	denotes	DNA repair
T3782	15326-15331	SO_EXT:0000704	denotes	genes
T3783	15338-15349	NCBITaxon:1	denotes	individuals
T3784	15375-15385	NCBITaxon:1	denotes	individual
T3785	15393-15403	NCBITaxon:1	denotes	individual
T3786	15631-15641	SO_EXT:0000673	denotes	transcript
T3787	15662-15667	PR_EXT:000005311	denotes	CEBPG
T3788	15669-15674	PR_EXT:000017504	denotes	XRCC1
T3789	15676-15681	PR_EXT:000007167	denotes	ERCC5
T3790	15683-15688	PR_EXT:000029950	denotes	GSTP1
T3791	15690-15694	PR_EXT:000015399	denotes	SOD1
T3792	15699-15703	PR_EXT:000008210	denotes	GPX1
T3793	15942-15953	NCBITaxon:1	denotes	individuals
T3794	15973-15984	NCBITaxon:1	denotes	individuals
T3795	16172-16183	NCBITaxon:1	denotes	individuals
T3796	16282-16292	SO_EXT:0000673	denotes	transcript
T3797	16314-16319	PR_EXT:000005311	denotes	CEBPG
T3798	16332-16342	SO_EXT:0000673	denotes	transcript
T3799	16376-16387	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3800	16380-16387	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3801	16391-16394	CHEBI_SO_EXT:DNA	denotes	DNA
T3802	16391-16401	GO:0006281	denotes	DNA repair
T3803	16402-16407	SO_EXT:0000704	denotes	genes
T3804	16567-16572	PR_EXT:000005311	denotes	CEBPG
T3805	16623-16634	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3806	16627-16634	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3807	16638-16641	CHEBI_SO_EXT:DNA	denotes	DNA
T3808	16638-16648	GO:0006281	denotes	DNA repair
T3809	16649-16654	SO_EXT:0000704	denotes	genes
T3810	16672-16683	NCBITaxon:1	denotes	individuals
T3811	16709-16720	NCBITaxon:1	denotes	individuals
T3812	16877-16882	PR_EXT:000005311	denotes	CEBPG
T3813	16910-16925	GO_EXT:transcription	denotes	transcriptional
T3814	16926-16936	GO:0065007	denotes	regulation
T3815	16944-16955	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3816	16948-16955	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3817	16959-16962	CHEBI_SO_EXT:DNA	denotes	DNA
T3818	16959-16969	GO:0006281	denotes	DNA repair
T3819	16970-16975	SO_EXT:0000704	denotes	genes
T3820	17008-17018	NCBITaxon:1	denotes	individual
T3821	17036-17046	GO:0065007	denotes	regulation
T3822	17064-17069	SO_EXT:0000704	denotes	genes
T3823	17073-17078	PR_EXT:000005311	denotes	CEBPG
T3824	17115-17126	NCBITaxon:1	denotes	individuals
T3825	17229-17239	GO:0065007	denotes	regulation
T3826	17265-17276	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3827	17269-17276	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3828	17281-17284	CHEBI_SO_EXT:DNA	denotes	DNA
T3829	17281-17291	GO:0006281	denotes	DNA repair
T3830	17292-17297	SO_EXT:0000704	denotes	genes
T3831	17357-17368	NCBITaxon:1	denotes	individuals
T3832	17372-17383	NCBITaxon:1	denotes	individuals
T3833	17417-17422	PR_EXT:000005311	denotes	CEBPG
T3834	17448-17459	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3835	17452-17459	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3836	17467-17470	CHEBI_SO_EXT:DNA	denotes	DNA
T3837	17467-17477	GO:0006281	denotes	DNA repair
T3838	17478-17483	SO_EXT:0000704	denotes	genes
T3839	17485-17490	PR_EXT:000005311	denotes	CEBPG
T3840	17496-17505	SO_EXT:sequence_truncation_process	denotes	truncated
T3841	17506-17510	PR_EXT:CEBP	denotes	CEBP
T3842	17511-17524	GO_EXT:transcription	denotes	transcription
T3843	17511-17531	GO_EXT:transcription_factor	denotes	transcription factor
T3844	17555-17564	SO_EXT:biological_sequence	denotes	sequences
T3845	17579-17582	CHEBI_SO_EXT:DNA	denotes	DNA
T3846	17583-17590	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T3847	17595-17616	GO:0046982	denotes	heterodimer formation
T3848	17601-17606	GO_EXT:dimer_macromolecular_complex	denotes	dimer
T3849	17632-17641	SO_EXT:biological_sequence	denotes	sequences
T3850	17678-17683	PR_EXT:000005311	denotes	CEBPG
T3851	17696-17702	GO_EXT:dimer_macromolecular_complex	denotes	dimers
T3852	17714-17718	PR_EXT:CEBP	denotes	CEBP
T3853	17747-17754	UBERON:0000479	denotes	tissues
T3854	17802-17815	GO_EXT:transcription	denotes	transcription
T3855	17823-17832	GO:0065007	denotes	regulated
T3856	17833-17837	SO_EXT:0000704	denotes	gene
T3857	17839-17844	PR_EXT:000005311	denotes	CEBPG
T3858	17888-17892	PR_EXT:000001393	denotes	IL-6
T3859	17897-17901	PR_EXT:000001395	denotes	IL-8
T3860	17902-17911	SO_EXT:0000167	denotes	promoters
T3861	17915-17921	CL:0000236	denotes	B cell
T3862	17917-17921	CL_GO_EXT:cell	denotes	cell
T3863	17965-17983	GO_EXT:negative_regulator	denotes	negative regulator
T3864	17987-17992	PR_EXT:000005307	denotes	CEBPA
T3865	17997-18002	PR_EXT:000005308	denotes	CEBPB
T3866	18006-18016	CL:0000057	denotes	fibroblast
T3867	18021-18027	CL:0000236	denotes	B cell
T3868	18023-18027	CL_GO_EXT:cell	denotes	cell
T3869	18054-18059	PR_EXT:000005311	denotes	CEBPG
T3870	18069-18073	NCBITaxon:10088	denotes	mice
T3871	18093-18098	PR_EXT:000005311	denotes	CEBPG
T3872	18113-18118	UBERON:0002048	denotes	lungs
T3873	18124-18131	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3874	18140-18145	PR_EXT:000005311	denotes	CEBPG
T3875	18145-18146	SO_EXT:sequence_nullness_or_absence	denotes	-
T3876	18147-18148	SO_EXT:sequence_nullness_or_absence	denotes	-
T3877	18158-18162	NCBITaxon:10088	denotes	mice
T3878	18178-18183	GO:0007567	denotes	birth
T3879	18197-18200	GO:0016265	denotes	die
T3880	18269-18274	UBERON:0002048	denotes	lungs
T3881	18284-18290	NCBITaxon:9606	denotes	humans
T3882	18330-18341	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3883	18334-18341	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3884	18529-18534	PR_EXT:000005311	denotes	CEBPG
T3885	18538-18548	GO:0065007	denotes	regulating
T3886	18553-18564	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3887	18557-18564	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3888	18569-18572	CHEBI_SO_EXT:DNA	denotes	DNA
T3889	18569-18579	GO:0006281	denotes	DNA repair
T3890	18580-18585	SO_EXT:0000704	denotes	genes
T3891	18630-18635	PR_EXT:000005311	denotes	CEBPG
T3892	18647-18651	SO_EXT:0000704	denotes	gene
T3893	18652-18662	SO_EXT:0000673	denotes	transcript
T3894	18716-18723	CHEBI_PR_EXT:protein	denotes	protein
T3895	18746-18750	PR_EXT:000006852	denotes	E2F1
T3896	18768-18771	CHEBI_SO_EXT:DNA	denotes	DNA
T3897	18768-18778	GO:0006281	denotes	DNA repair
T3898	18783-18794	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3899	18787-18794	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3900	18795-18800	SO_EXT:0000704	denotes	genes
T3901	18845-18850	PR_EXT:000005311	denotes	CEBPG
T3902	18860-18864	PR_EXT:000006852	denotes	E2F1
T3903	18905-18916	NCBITaxon:1	denotes	individuals
T3904	18931-18942	NCBITaxon:1	denotes	individuals
T3905	18974-18978	PR_EXT:000006852	denotes	E2F1
T3906	18984-18987	CHEBI_SO_EXT:DNA	denotes	DNA
T3907	18984-18994	GO:0006281	denotes	DNA repair
T3908	18999-19010	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3909	19003-19010	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3910	19011-19016	SO_EXT:0000704	denotes	genes
T3911	19023-19034	NCBITaxon:1	denotes	individuals
T3912	19079-19089	GO:0065007	denotes	controlled
T3913	19166-19170	PR_EXT:000006852	denotes	E2F1
T3914	19203-19211	GO:0065007	denotes	regulate
T3915	19212-19225	GO_EXT:transcription	denotes	transcription
T3916	19229-19232	CHEBI_SO_EXT:DNA	denotes	DNA
T3917	19229-19239	GO:0006281	denotes	DNA repair
T3918	19240-19246	CHEBI_GO_SO_EXT:enzyme	denotes	enzyme
T3919	19247-19252	SO_EXT:0000704	denotes	genes
T3920	19262-19266	CL_GO_EXT:cell	denotes	cell
T3921	19292-19297	NCBITaxon:9606	denotes	human
T3922	19298-19309	CL:0000057	denotes	fibroblasts
T3923	19314-19319	NCBITaxon:10088	denotes	mouse
T3924	19320-19329	UBERON:0007376	denotes	epidermal
T3925	19320-19335	CL:0000362	denotes	epidermal cells
T3926	19330-19335	CL_GO_EXT:cell	denotes	cells
T3927	19390-19393	CHEBI_SO_EXT:DNA	denotes	DNA
T3928	19390-19400	GO:0006281	denotes	DNA repair
T3929	19401-19405	SO_EXT:0000704	denotes	gene
T3930	19406-19419	GO_EXT:positive_regulation	denotes	up-regulation
T3931	19423-19431	GO_EXT:reaction_or_response	denotes	response
T3932	19435-19439	PR_EXT:000006852	denotes	E2F1
T3933	19460-19463	CHEBI_SO_EXT:DNA	denotes	DNA
T3934	19460-19470	GO:0006281	denotes	DNA repair
T3935	19480-19483	CHEBI_SO_EXT:DNA	denotes	DNA
T3936	19487-19498	GO:0006260	denotes	replicating
T3937	19606-19615	SO_EXT:sequence_variation_entity_or_quality	denotes	variation
T3938	19619-19622	CHEBI_SO_EXT:DNA	denotes	DNA
T3939	19623-19631	SO_EXT:biological_sequence	denotes	sequence
T3940	19636-19648	SO_EXT:polymorphism	denotes	polymorphism
T3941	19859-19871	SO_EXT:polymorphism	denotes	polymorphism
T3942	19895-19908	SO_EXT:polymorphism	denotes	polymorphisms
T3943	19932-19944	SO_EXT:polymorphism	denotes	polymorphism
T3944	19981-19985	SO_EXT:0000704	denotes	gene
T3945	20003-20023	UBERON:0002031	denotes	bronchial epithelium
T3946	20029-20040	CHEBI_EXT:50903	denotes	carcinogens
T3947	20042-20050	CHEBI_EXT:63248	denotes	oxidants
T3948	20055-20058	CHEBI_SO_EXT:DNA	denotes	DNA
T3949	20099-20111	SO_EXT:polymorphism	denotes	polymorphism
T3950	20235-20248	SO_EXT:polymorphism	denotes	polymorphisms
T3951	20314-20327	SO_EXT:polymorphism	denotes	polymorphisms
T3952	20541-20551	CHEBI_SO_EXT:biomarker	denotes	biomarkers
T3953	20634-20643	GO:0065007	denotes	regulated
T3954	20644-20657	GO_EXT:transcription	denotes	transcription
T3955	20672-20677	SO_EXT:0000704	denotes	genes
T3956	20693-20706	GO_EXT:transcription	denotes	transcription
T3957	20693-20714	GO_EXT:transcription_factor	denotes	transcription factors
T3958	20828-20833	SO_EXT:0000704	denotes	genes
T3959	20923-20933	SO_EXT:0000673	denotes	transcript
T3960	21030-21035	SO_EXT:0000704	denotes	genes
T3961	21099-21112	SO_EXT:polymorphism	denotes	polymorphisms
T3962	21125-21135	GO:0065007	denotes	regulation
T3963	21139-21144	PR_EXT:000017504	denotes	XRCC1
T3964	21146-21151	PR_EXT:000007167	denotes	ERCC5
T3965	21153-21158	PR_EXT:000029950	denotes	GSTP1
T3966	21160-21164	PR_EXT:000015399	denotes	SOD1
T3967	21170-21174	PR_EXT:000008210	denotes	GPX1
T3968	21178-21183	PR_EXT:000005311	denotes	CEBPG
T3969	21190-21203	SO_EXT:polymorphism	denotes	polymorphisms
T3970	21217-21227	CHEBI_SO_EXT:biomarker	denotes	biomarkers
T3971	21293-21298	UBERON:0000178	denotes	blood
T3972	21302-21308	UBERON:0001567	denotes	buccal
T3973	21319-21328	CHEBI_SO_EXT:biomarker	denotes	biomarker
T3974	21339-21352	SO_EXT:polymorphism	denotes	polymorphisms
T3975	21365-21375	GO:0065007	denotes	regulation
T3976	21411-21422	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T3977	21415-21422	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T3978	21427-21430	CHEBI_SO_EXT:DNA	denotes	DNA
T3979	21427-21437	GO:0006281	denotes	DNA repair
T3980	21438-21443	SO_EXT:0000704	denotes	genes
T3981	21494-21505	NCBITaxon:1	denotes	individuals
T3982	21522-21532	CHEBI_SO_EXT:biomarker	denotes	Biomarkers
T3983	21558-21569	NCBITaxon:1	denotes	individuals
T3984	21718-21722	SO_EXT:0000704	denotes	gene
T3985	21732-21742	CHEBI_EXT:35222	denotes	inhibitors
T3986	21851-21861	SO_EXT:0000673	denotes	transcript
T3987	22010-22020	SO_EXT:0000673	denotes	transcript
T3988	22127-22137	SO_EXT:0000673	denotes	transcript
T3989	22176-22186	SO_EXT:0000673	denotes	transcript
T3990	22241-22246	SO_EXT:0000704	denotes	genes
T3991	22268-22278	SO_EXT:0000673	denotes	transcript
T3992	22316-22326	SO_EXT:0000673	denotes	transcript
T3993	22371-22376	SO_EXT:0000704	denotes	genes
T3994	22389-22398	GO:0065007	denotes	regulated
T3995	22406-22419	GO_EXT:transcription	denotes	transcription
T5769	22466-22477	NCBITaxon:1	denotes	individuals
T5770	22479-22484	PR_EXT:000005311	denotes	CEBPG
T5771	22485-22494	GO:0065007	denotes	regulates
T5772	22495-22508	GO_EXT:transcription	denotes	transcription
T5773	22516-22527	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T5774	22520-22527	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T5775	22531-22534	CHEBI_SO_EXT:DNA	denotes	DNA
T5776	22531-22541	GO:0006281	denotes	DNA repair
T5777	22542-22547	SO_EXT:0000704	denotes	genes
T5778	22592-22597	PR_EXT:000005311	denotes	CEBPG
T5779	22598-22608	GO:0065007	denotes	regulation
T5780	22651-22662	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T5781	22655-22662	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T5782	22670-22673	CHEBI_SO_EXT:DNA	denotes	DNA
T5783	22670-22680	GO:0006281	denotes	DNA repair
T5784	22681-22686	SO_EXT:0000704	denotes	genes
R1577	T2419	T2418	_lexicallyChainedTo	transcription factors,sites for

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T204	0-5	PR:000005311	denotes	CEBPG
T205	59-69	GO:0006281	denotes	DNA repair
T206	70-75	SO:0000704	denotes	genes
T207	86-106	UBERON:0002031	denotes	bronchial epithelial
T208	86-112	CL:0002328	denotes	bronchial epithelial cells
T209	124-135	NCBITaxon:1	denotes	individuals
T210	358-369	SO:0000704	denotes	genetically
T211	426-431	SO:0000704	denotes	genes
T212	442-452	SO:0000673	denotes	transcript
T213	483-503	UBERON:0002031	denotes	bronchial epithelial
T214	483-509	CL:0002328	denotes	bronchial epithelial cells
T215	523-534	NCBITaxon:1	denotes	individuals
T216	554-565	NCBITaxon:1	denotes	individuals
T217	616-626	SO:0000673	denotes	transcript
T218	656-666	GO:0006281	denotes	DNA repair
T219	667-672	SO:0000704	denotes	genes
T220	712-717	SO:0000704	denotes	genes
T221	773-783	GO:0006281	denotes	DNA repair
T222	784-789	SO:0000704	denotes	genes
T223	797-806	GO:0065007	denotes	regulated
T224	859-869	NCBITaxon:1	denotes	individual
T225	883-893	GO:0010467	denotes	expression
T226	981-991	NCBITaxon:1	denotes	individual
T227	1040-1078	SO:0000235	denotes	transcription factor recognition sites
T228	1112-1117	SO:0000704	denotes	genes
T229	1179-1189	SO:0000673	denotes	transcript
T230	1287-1297	GO:0006281	denotes	DNA repair
T231	1298-1303	SO:0000704	denotes	genes
T232	1393-1404	NCBITaxon:1	denotes	individuals
T233	1415-1420	PR:000005311	denotes	CEBPG
T234	1515-1525	GO:0006281	denotes	DNA repair
T235	1526-1531	SO:0000704	denotes	genes
T236	1542-1553	NCBITaxon:1	denotes	individuals
T237	1568-1579	NCBITaxon:1	denotes	individuals
T238	1587-1598	NCBITaxon:1	denotes	individuals
T239	1620-1625	PR:000005311	denotes	CEBPG
T240	1681-1692	NCBITaxon:1	denotes	individuals
T241	1709-1714	SO:0000704	denotes	genes
T242	1716-1721	PR:000017504	denotes	XRCC1
T243	1723-1728	PR:000007167	denotes	ERCC5
T244	1730-1735	PR:000029950	denotes	GSTP1
T245	1741-1745	PR:000015399	denotes	SOD1
T246	1793-1797	PR:000008210	denotes	GPX1
T247	1876-1881	SO:0000704	denotes	genes
T248	1892-1903	NCBITaxon:1	denotes	individuals
T249	1908-1912	PR:000006852	denotes	E2F1
T250	1914-1918	PR:000006852	denotes	E2F1
T251	1939-1944	PR:000029950	denotes	GSTP1
T252	1958-1969	NCBITaxon:1	denotes	individuals
T253	1990-1995	PR:000005311	denotes	CEBPG
T254	2063-2074	NCBITaxon:1	denotes	individuals
T255	2090-2101	NCBITaxon:1	denotes	individuals
T256	2132-2137	PR:000005311	denotes	CEBPG
T257	2192-2202	GO:0065007	denotes	regulating
T258	2240-2250	GO:0006281	denotes	DNA repair
T259	2251-2256	SO:0000704	denotes	genes
T260	2267-2278	NCBITaxon:1	denotes	individuals
T261	2386-2396	GO:0065007	denotes	regulation
T262	2416-2426	GO:0006281	denotes	DNA repair
T263	2427-2432	SO:0000704	denotes	genes
T264	2436-2441	PR:000005311	denotes	CEBPG
T869	2507-2512	GO:0016265	denotes	death
T870	2561-2567	GO:0016265	denotes	deaths
T871	2720-2730	GO:0006281	denotes	DNA repair
T872	2803-2812	GO:0010467	denotes	expressed
T873	2852-2872	UBERON:0002031	denotes	bronchial epithelial
T874	2852-2878	CL:0002328	denotes	bronchial epithelial cells
T875	2907-2917	NCBITaxon:1	denotes	individual
T876	2953-2958	SO:0000704	denotes	genes
T877	3044-3067	CHEBI:26523	denotes	reactive oxygen species
T878	3101-3126	GO:0006805	denotes	metabolism of xenobiotics
T879	3115-3126	CHEBI:35703	denotes	xenobiotics
T880	3207-3226	GO:0044237	denotes	cellular metabolism
T881	3228-3251	CHEBI:26523	denotes	Reactive oxygen species
T882	3292-3316	GO:0030164	denotes	denaturation of proteins
T883	3335-3341	CHEBI:18059	denotes	lipids
T884	3375-3382	GO:0005634	denotes	nucleic
T885	3425-3435	GO:0006281	denotes	DNA repair
T886	3444-3450	GO:0006281	denotes	repair
T887	3567-3578	CHEBI:50903	denotes	carcinogens
T888	3646-3656	SO:0000673	denotes	transcript
T889	3696-3701	SO:0000704	denotes	genes
T890	3726-3737	NCBITaxon:1	denotes	individuals
T891	3757-3768	NCBITaxon:1	denotes	individuals
T892	3789-3800	NCBITaxon:1	denotes	individuals
T893	3922-3932	SO:0000673	denotes	transcript
T894	3983-3993	GO:0006281	denotes	DNA repair
T895	3994-3999	SO:0000704	denotes	genes
T896	4010-4021	NCBITaxon:1	denotes	individuals
T897	4037-4048	NCBITaxon:1	denotes	individuals
T898	4050-4054	SO:0000704	denotes	Gene
T899	4095-4100	PR:000029950	denotes	GSTP1
T900	4101-4105	PR:000008210	denotes	GPX1
T901	4111-4115	PR:000008212	denotes	GPX3
T902	4121-4125	PR:000008212	denotes	GPX3
T903	4126-4130	PR:000015399	denotes	SOD1
T904	4180-4189	GO:0065007	denotes	regulated
T905	4190-4195	SO:0000704	denotes	genes
T906	4215-4253	SO:0000235	denotes	transcription factor recognition sites
T907	4261-4271	GO:0065007	denotes	regulatory
T908	4261-4279	SO:0005836	denotes	regulatory regions
T909	4289-4294	SO:0000704	denotes	genes
T910	4377-4387	NCBITaxon:1	denotes	individual
T911	4401-4411	GO:0065007	denotes	regulation
T912	4435-4445	GO:0006281	denotes	DNA repair
T913	4446-4451	SO:0000704	denotes	genes
T914	4506-4517	NCBITaxon:1	denotes	individuals
T915	4535-4545	GO:0065007	denotes	regulation
T916	4633-4671	SO:0000235	denotes	transcription factor recognition sites
T917	4686-4696	GO:0065007	denotes	regulatory
T918	4686-4704	SO:0005836	denotes	regulatory regions
T919	4729-4733	SO:0000704	denotes	gene
T920	4807-4817	SO:0000673	denotes	transcript
T921	4902-4912	GO:0006281	denotes	DNA repair
T922	4913-4918	SO:0000704	denotes	genes
T1580	5759-5769	SO:0000673	denotes	Transcript
T1581	5835-5854	GO:0001171	denotes	reverse transcribed
T1582	5861-5866	NCBITaxon:11801	denotes	M-MLV
T1583	5902-5909	SO:0000112	denotes	primers
T1584	5983-5993	SO:0000673	denotes	transcript
T1585	6080-6084	SO:0000704	denotes	gene
T1586	6294-6302	CHEBI:33893	denotes	reagents
T1587	6463-6467	SO:0000704	denotes	Gene
T1588	6508-6516	CHEBI:33893	denotes	reagents
T1589	6570-6574	SO:0000704	denotes	Gene
T1590	6615-6623	CHEBI:33893	denotes	reagents
T1591	6649-6654	SO:0000704	denotes	genes
T1592	6703-6710	SO:0000112	denotes	primers
T1593	6815-6822	SO:0000112	denotes	primers
T1594	6978-6988	CHEBI:35222	denotes	inhibitors
T1595	7037-7047	SO:0000673	denotes	transcript
T1596	7403-7415	SO:0000006	denotes	PCR products
T1597	7749-7754	SO:0000704	denotes	genes
T1598	7788-7792	SO:0000704	denotes	gene
T1599	7807-7815	CHEBI:33893	denotes	reagents
T1600	7862-7871	CHEBI:36357	denotes	molecules
T1601	7957-7966	CHEBI:36357	denotes	molecules
T1602	8114-8124	CHEBI:35222	denotes	inhibitors
T1603	8142-8146	SO:0000704	denotes	gene
T1604	8228-8239	SO:0000006	denotes	PCR product
T2152	8659-8670	NCBITaxon:1	denotes	individuals
T2153	8758-8768	GO:0006281	denotes	DNA repair
T2154	8769-8774	SO:0000704	denotes	genes
T2155	8926-8936	GO:0010467	denotes	expression
T2156	8945-8949	SO:0000704	denotes	gene
T2157	8960-8971	NCBITaxon:1	denotes	individuals
T2158	9164-9174	GO:0006281	denotes	DNA repair
T2159	9175-9180	SO:0000704	denotes	genes
T2160	9371-9381	SO:0000673	denotes	transcript
T2161	9406-9410	SO:0000704	denotes	gene
T2462	10342-10350	CHEBI:33893	denotes	reagents
T2449	9544-9581	SO:0000235	denotes	Transcription factor recognition site
T2450	9694-9699	SO:0000704	denotes	genes
T2451	9711-9717	SO:0001026	denotes	genome
T2452	9734-9744	SO:0000028	denotes	base pairs
T2453	9752-9760	SO:0000167	denotes	promoter
T2454	9775-9785	SO:0000028	denotes	base pairs
T2455	9806-9816	SO:0000028	denotes	base pairs
T2456	9826-9850	SO:0000315	denotes	transcription start site
T2457	9861-9865	SO:0000704	denotes	gene
T2458	9925-9934	SO:0000028	denotes	base pair
T2459	10033-10070	SO:0000235	denotes	transcription factor recognition site
T2460	10144-10153	_FRAGMENT	denotes	sites for
T2461	10157-10178	SO:0000235	denotes	transcription factors
T2463	10416-10421	PR:000005308	denotes	CEBPB
T2464	10423-10428	PR:000005310	denotes	CEBPE
T2465	10430-10435	PR:000005311	denotes	CEBPG
T2466	10437-10441	PR:000006852	denotes	E2F1
T2467	10443-10447	PR:000006854	denotes	E2F3
T2468	10449-10453	PR:000006855	denotes	E2F4
T2469	10455-10459	PR:000006856	denotes	E2F5
T2470	10461-10465	PR:000006857	denotes	E2F6
T2471	10467-10471	PR:000035849	denotes	EVI1
T2472	10477-10481	PR:000001903	denotes	PAX5
T2473	10515-10524	GO:0010467	denotes	expressed
T2474	10644-10649	PR:000005308	denotes	CEBPB
T2475	10651-10656	PR:000005311	denotes	CEBPG
T2476	10658-10662	PR:000006852	denotes	E2F1
T2477	10664-10668	PR:000006854	denotes	E2F3
T2478	10670-10674	PR:000006857	denotes	E2F6
T2479	10680-10683	PR:000035849	denotes	EVI
T2480	10766-10776	GO:0006281	denotes	DNA repair
T2481	10777-10782	SO:0000704	denotes	genes
T2737	7037-7047	SO:0000673	denotes	transcript
T2738	10864-10868	SO:0000704	denotes	gene
T2739	10907-10911	PR:000006852	denotes	E2F1
T2740	10951-10955	SO:0000704	denotes	gene
T2741	10965-10974	CHEBI:35222	denotes	inhibitor
T2742	11016-11020	PR:000006852	denotes	E2F1
T2743	11073-11084	SO:0000006	denotes	PCR product
T2744	11115-11119	SO:0000704	denotes	gene
T2745	11231-11243	SO:0000006	denotes	PCR products
T2746	11306-11315	CHEBI:36357	denotes	molecules
T3014	11489-11500	NCBITaxon:1	denotes	individuals
T3015	11554-11559	PR:000005311	denotes	CEBPG
T3016	11595-11605	GO:0006281	denotes	DNA repair
T3017	11606-11611	SO:0000704	denotes	genes
T3018	11626-11631	PR:000017504	denotes	XRCC1
T3019	11633-11638	PR:000007167	denotes	ERCC5
T3020	11640-11645	PR:000029950	denotes	GSTP1
T3021	11647-11651	PR:000015399	denotes	SOD1
T3022	11653-11657	PR:000008210	denotes	GPX1
T3023	11659-11664	PR:000007163	denotes	ERCC1
T3024	11674-11679	PR:000007164	denotes	ERCC2
T3025	11710-11721	NCBITaxon:1	denotes	individuals
T3026	11730-11735	PR:000005311	denotes	CEBPG
T3027	11786-11796	GO:0006281	denotes	DNA repair
T3028	11797-11802	SO:0000704	denotes	genes
T3029	11899-11904	PR:000017504	denotes	XRCC1
T3030	11906-11911	PR:000007167	denotes	ERCC5
T3031	11913-11918	PR:000029950	denotes	GSTP1
T3032	11924-11928	PR:000015399	denotes	SOD1
T3033	11950-11955	PR:000005311	denotes	CEBPG
T3034	11986-11997	NCBITaxon:1	denotes	individuals
T3035	12017-12028	NCBITaxon:1	denotes	individuals
T3036	12075-12079	PR:000008210	denotes	GPX1
T3037	12133-12138	PR:000005311	denotes	CEBPG
T3038	12143-12148	PR:000017504	denotes	XRCC1
T3039	12159-12170	NCBITaxon:1	denotes	individuals
T3040	12177-12188	NCBITaxon:1	denotes	individuals
T3041	12238-12243	SO:0000704	denotes	genes
T3042	12253-12258	PR:000005311	denotes	CEBPG
T3043	12264-12269	PR:000017504	denotes	XRCC1
T3044	12271-12276	PR:000007167	denotes	ERCC5
T3045	12278-12283	PR:000029950	denotes	GSTP1
T3046	12285-12289	PR:000015399	denotes	SOD1
T3047	12293-12297	PR:000008210	denotes	GPX1
T3048	12374-12385	NCBITaxon:1	denotes	individuals
T3049	12390-12401	NCBITaxon:1	denotes	individuals
T3050	12436-12447	NCBITaxon:1	denotes	individuals
T3051	12509-12514	PR:000005311	denotes	CEBPG
T3052	12552-12562	GO:0010467	denotes	expression
T3053	12566-12571	PR:000017504	denotes	XRCC1
T3054	12579-12584	PR:000007167	denotes	ERCC5
T3055	12592-12597	PR:000029950	denotes	GSTP1
T3056	12605-12609	PR:000015399	denotes	SOD1
T3057	12621-12625	PR:000008210	denotes	GPX1
T3058	12633-12637	PR:000006852	denotes	E2F1
T3059	12728-12739	NCBITaxon:1	denotes	individuals
T3060	12747-12758	NCBITaxon:1	denotes	individuals
T3061	12792-12796	PR:000006852	denotes	E2F1
T3062	12831-12836	PR:000007167	denotes	ERCC5
T3063	12838-12843	PR:000029950	denotes	GSTP1
T3064	12848-12852	PR:000015399	denotes	SOD1
T3065	12883-12894	NCBITaxon:1	denotes	individuals
T3066	12896-12900	PR:000006852	denotes	E2F1
T3067	12921-12926	PR:000029950	denotes	GSTP1
T3068	12973-12984	NCBITaxon:1	denotes	individuals
T3069	13040-13051	NCBITaxon:1	denotes	individuals
T3070	13059-13070	NCBITaxon:1	denotes	individuals
T3071	13153-13158	PR:000017504	denotes	XRCC1
T3072	13160-13165	PR:000007167	denotes	ERCC5
T3073	13167-13172	PR:000029950	denotes	GSTP1
T3074	13174-13178	PR:000015399	denotes	SOD1
T3075	13183-13187	PR:000008210	denotes	GPX1
T3458	13220-13224	SO:0000704	denotes	gene
T3459	13220-13235	GO:0010467	denotes	gene expression
T3460	13269-13273	PR:000006852	denotes	E2F1
T3461	13278-13283	PR:000008307	denotes	GSTZ1
T3462	13326-13331	PR:000008300	denotes	GSTM1
T3463	13347-13351	SO:0000704	denotes	gene
T3464	13373-13383	GO:0010467	denotes	expression
T3465	13421-13426	PR:000007164	denotes	ERCC2
T3466	13427-13437	GO:0010467	denotes	expression
T3996	13552-13562	NCBITaxon:1	denotes	individual
T3997	13576-13586	GO:0065007	denotes	regulation
T3998	13610-13620	GO:0006281	denotes	DNA repair
T3999	13621-13626	SO:0000704	denotes	genes
T4000	13678-13689	NCBITaxon:1	denotes	individuals
T4001	13707-13717	GO:0065007	denotes	regulation
T4002	13856-13866	NCBITaxon:1	denotes	individual
T4003	13880-13890	SO:0000673	denotes	transcript
T4004	13901-13906	PR:000005311	denotes	CEBPG
T4005	13930-13935	SO:0000704	denotes	genes
T4006	13950-13961	NCBITaxon:1	denotes	individuals
T4007	13966-13971	PR:000005311	denotes	CEBPG
T4008	13972-13982	SO:0000673	denotes	transcript
T4009	14061-14071	SO:0000673	denotes	transcript
T4010	14117-14127	GO:0006281	denotes	DNA repair
T4011	14128-14133	SO:0000704	denotes	genes
T4012	14144-14155	NCBITaxon:1	denotes	individuals
T4013	14202-14207	PR:000005311	denotes	CEBPG
T4014	14218-14223	SO:0000704	denotes	genes
T4015	14230-14241	NCBITaxon:1	denotes	individuals
T4016	14312-14322	GO:0006281	denotes	DNA repair
T4017	14323-14328	SO:0000704	denotes	genes
T4018	14345-14350	PR:000005311	denotes	CEBPG
T4019	14361-14372	NCBITaxon:1	denotes	individuals
T4020	14376-14385	GO:0065007	denotes	regulated
T4021	14389-14394	PR:000005311	denotes	CEBPG
T4022	14440-14445	PR:000005311	denotes	CEBPG
T4023	14576-14581	SO:0000704	denotes	genes
T4024	14643-14648	SO:0000704	denotes	genes
T4025	14654-14659	PR:000005308	denotes	CEBPB
T4026	14685-14701	SO:0000409	denotes	recognition site
T4027	14705-14710	PR:000005311	denotes	CEBPG
T4028	14727-14743	SO:0000409	denotes	recognition site
T4029	14778-14788	GO:0006281	denotes	DNA repair
T4030	14789-14794	SO:0000704	denotes	genes
T4031	14872-14877	PR:000005311	denotes	CEBPG
T4032	14899-14909	GO:0006281	denotes	DNA repair
T4033	14910-14915	SO:0000704	denotes	genes
T4034	14926-14937	NCBITaxon:1	denotes	individuals
T4035	14963-14968	PR:000005311	denotes	CEBPG
T4036	15011-15021	GO:0006281	denotes	DNA repair
T4037	15022-15027	SO:0000704	denotes	genes
T4038	15031-15040	GO:0065007	denotes	regulated
T4039	15109-15125	SO:0000409	denotes	recognition site
T4040	15290-15295	PR:000005311	denotes	CEBPG
T4041	15315-15325	GO:0006281	denotes	DNA repair
T4042	15326-15331	SO:0000704	denotes	genes
T4043	15338-15349	NCBITaxon:1	denotes	individuals
T4044	15375-15385	NCBITaxon:1	denotes	individual
T4045	15393-15403	NCBITaxon:1	denotes	individual
T4046	15631-15641	SO:0000673	denotes	transcript
T4047	15662-15667	PR:000005311	denotes	CEBPG
T4048	15669-15674	PR:000017504	denotes	XRCC1
T4049	15676-15681	PR:000007167	denotes	ERCC5
T4050	15683-15688	PR:000029950	denotes	GSTP1
T4051	15690-15694	PR:000015399	denotes	SOD1
T4052	15699-15703	PR:000008210	denotes	GPX1
T4053	15942-15953	NCBITaxon:1	denotes	individuals
T4054	15973-15984	NCBITaxon:1	denotes	individuals
T4055	16172-16183	NCBITaxon:1	denotes	individuals
T4056	16282-16292	SO:0000673	denotes	transcript
T4057	16314-16319	PR:000005311	denotes	CEBPG
T4058	16332-16342	SO:0000673	denotes	transcript
T4059	16391-16401	GO:0006281	denotes	DNA repair
T4060	16402-16407	SO:0000704	denotes	genes
T4061	16567-16572	PR:000005311	denotes	CEBPG
T4062	16638-16648	GO:0006281	denotes	DNA repair
T4063	16649-16654	SO:0000704	denotes	genes
T4064	16672-16683	NCBITaxon:1	denotes	individuals
T4065	16709-16720	NCBITaxon:1	denotes	individuals
T4066	16877-16882	PR:000005311	denotes	CEBPG
T4067	16926-16936	GO:0065007	denotes	regulation
T4068	16959-16969	GO:0006281	denotes	DNA repair
T4069	16970-16975	SO:0000704	denotes	genes
T4070	17008-17018	NCBITaxon:1	denotes	individual
T4071	17036-17046	GO:0065007	denotes	regulation
T4072	17064-17069	SO:0000704	denotes	genes
T4073	17073-17078	PR:000005311	denotes	CEBPG
T4074	17115-17126	NCBITaxon:1	denotes	individuals
T4075	17229-17239	GO:0065007	denotes	regulation
T4076	17281-17291	GO:0006281	denotes	DNA repair
T4077	17292-17297	SO:0000704	denotes	genes
T4078	17357-17368	NCBITaxon:1	denotes	individuals
T4079	17372-17383	NCBITaxon:1	denotes	individuals
T4080	17417-17422	PR:000005311	denotes	CEBPG
T4081	17467-17477	GO:0006281	denotes	DNA repair
T4082	17478-17483	SO:0000704	denotes	genes
T4083	17485-17490	PR:000005311	denotes	CEBPG
T4084	17595-17616	GO:0046982	denotes	heterodimer formation
T4085	17678-17683	PR:000005311	denotes	CEBPG
T4086	17747-17754	UBERON:0000479	denotes	tissues
T4087	17823-17832	GO:0065007	denotes	regulated
T4088	17833-17837	SO:0000704	denotes	gene
T4089	17839-17844	PR:000005311	denotes	CEBPG
T4090	17888-17892	PR:000001393	denotes	IL-6
T4091	17897-17901	PR:000001395	denotes	IL-8
T4092	17902-17911	SO:0000167	denotes	promoters
T4093	17915-17921	CL:0000236	denotes	B cell
T4094	17987-17992	PR:000005307	denotes	CEBPA
T4095	17997-18002	PR:000005308	denotes	CEBPB
T4096	18006-18016	CL:0000057	denotes	fibroblast
T4097	18021-18027	CL:0000236	denotes	B cell
T4098	18054-18059	PR:000005311	denotes	CEBPG
T4099	18069-18073	NCBITaxon:10088	denotes	mice
T4100	18093-18098	PR:000005311	denotes	CEBPG
T4101	18113-18118	UBERON:0002048	denotes	lungs
T4102	18140-18145	PR:000005311	denotes	CEBPG
T4103	18158-18162	NCBITaxon:10088	denotes	mice
T4104	18178-18183	GO:0007567	denotes	birth
T4105	18197-18200	GO:0016265	denotes	die
T4106	18269-18274	UBERON:0002048	denotes	lungs
T4107	18284-18290	NCBITaxon:9606	denotes	humans
T4108	18529-18534	PR:000005311	denotes	CEBPG
T4109	18538-18548	GO:0065007	denotes	regulating
T4110	18569-18579	GO:0006281	denotes	DNA repair
T4111	18580-18585	SO:0000704	denotes	genes
T4112	18630-18635	PR:000005311	denotes	CEBPG
T4113	18647-18651	SO:0000704	denotes	gene
T4114	18652-18662	SO:0000673	denotes	transcript
T4115	18746-18750	PR:000006852	denotes	E2F1
T4116	18768-18778	GO:0006281	denotes	DNA repair
T4117	18795-18800	SO:0000704	denotes	genes
T4118	18845-18850	PR:000005311	denotes	CEBPG
T4119	18860-18864	PR:000006852	denotes	E2F1
T4120	18905-18916	NCBITaxon:1	denotes	individuals
T4121	18931-18942	NCBITaxon:1	denotes	individuals
T4122	18974-18978	PR:000006852	denotes	E2F1
T4123	18984-18994	GO:0006281	denotes	DNA repair
T4124	19011-19016	SO:0000704	denotes	genes
T4125	19023-19034	NCBITaxon:1	denotes	individuals
T4126	19079-19089	GO:0065007	denotes	controlled
T4127	19166-19170	PR:000006852	denotes	E2F1
T4128	19203-19211	GO:0065007	denotes	regulate
T4129	19229-19239	GO:0006281	denotes	DNA repair
T4130	19247-19252	SO:0000704	denotes	genes
T4131	19292-19297	NCBITaxon:9606	denotes	human
T4132	19298-19309	CL:0000057	denotes	fibroblasts
T4133	19314-19319	NCBITaxon:10088	denotes	mouse
T4134	19320-19329	UBERON:0007376	denotes	epidermal
T4135	19320-19335	CL:0000362	denotes	epidermal cells
T4136	19390-19400	GO:0006281	denotes	DNA repair
T4137	19401-19405	SO:0000704	denotes	gene
T4138	19435-19439	PR:000006852	denotes	E2F1
T4139	19460-19470	GO:0006281	denotes	DNA repair
T4140	19487-19498	GO:0006260	denotes	replicating
T4141	19981-19985	SO:0000704	denotes	gene
T4142	20003-20023	UBERON:0002031	denotes	bronchial epithelium
T4143	20029-20040	CHEBI:50903	denotes	carcinogens
T4144	20042-20050	CHEBI:63248	denotes	oxidants
T4145	20634-20643	GO:0065007	denotes	regulated
T4146	20672-20677	SO:0000704	denotes	genes
T4147	20828-20833	SO:0000704	denotes	genes
T4148	20923-20933	SO:0000673	denotes	transcript
T4149	21030-21035	SO:0000704	denotes	genes
T4150	21125-21135	GO:0065007	denotes	regulation
T4151	21139-21144	PR:000017504	denotes	XRCC1
T4152	21146-21151	PR:000007167	denotes	ERCC5
T4153	21153-21158	PR:000029950	denotes	GSTP1
T4154	21160-21164	PR:000015399	denotes	SOD1
T4155	21170-21174	PR:000008210	denotes	GPX1
T4156	21178-21183	PR:000005311	denotes	CEBPG
T4157	21293-21298	UBERON:0000178	denotes	blood
T4158	21302-21308	UBERON:0001567	denotes	buccal
T4159	21365-21375	GO:0065007	denotes	regulation
T4160	21427-21437	GO:0006281	denotes	DNA repair
T4161	21438-21443	SO:0000704	denotes	genes
T4162	21494-21505	NCBITaxon:1	denotes	individuals
T4163	21558-21569	NCBITaxon:1	denotes	individuals
T4164	21718-21722	SO:0000704	denotes	gene
T5785	22466-22477	NCBITaxon:1	denotes	individuals
T5786	22479-22484	PR:000005311	denotes	CEBPG
T5787	22485-22494	GO:0065007	denotes	regulates
T5788	22531-22541	GO:0006281	denotes	DNA repair
T5789	22542-22547	SO:0000704	denotes	genes
T5790	22592-22597	PR:000005311	denotes	CEBPG
T5791	22598-22608	GO:0065007	denotes	regulation
T5792	22670-22680	GO:0006281	denotes	DNA repair
T5793	22681-22686	SO:0000704	denotes	genes
T1383	4985-5005	UBERON:0002031	denotes	bronchial epithelium
T1384	5137-5157	UBERON:0002031	denotes	bronchial epithelium
T1385	5165-5169	UBERON:0002048	denotes	lung
T1386	5580-5591	NCBITaxon:1	denotes	individuals
T1387	5613-5624	NCBITaxon:1	denotes	individuals
T1388	5635-5646	NCBITaxon:1	denotes	individuals
T1389	5720-5731	NCBITaxon:1	denotes	individuals
T2147	8417-8427	SO:0000673	denotes	transcript
T2148	8573-8583	GO:0006281	denotes	DNA repair
T2149	8584-8589	SO:0000704	denotes	genes
T2150	8614-8625	NCBITaxon:1	denotes	individuals
T2151	8637-8648	NCBITaxon:1	denotes	individuals
T4165	21732-21742	CHEBI:35222	denotes	inhibitors
T4166	21851-21861	SO:0000673	denotes	transcript
T4167	22010-22020	SO:0000673	denotes	transcript
T4168	22127-22137	SO:0000673	denotes	transcript
T4169	22176-22186	SO:0000673	denotes	transcript
T4170	22241-22246	SO:0000704	denotes	genes
T4171	22268-22278	SO:0000673	denotes	transcript
T4172	22316-22326	SO:0000673	denotes	transcript
T4173	22371-22376	SO:0000704	denotes	genes
T4174	22389-22398	GO:0065007	denotes	regulated
R1578	T2461	T2460	_lexicallyChainedTo	transcription factors,sites for

PMC:1310620 JSONTXT

Annnotations TAB JSON ListView MergeView

craft-sa-dev

2_test

craft-ca-core-ex-dev

craft-ca-core-dev

PMC:1310620 JSON TXT