PMC:1283364 / 736-963 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1283364","sourcedb":"PMC","sourceid":"1283364","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1283364","text":" Findings\nWe have generated a transgenic mouse model that genetically mimics the arrest of Aβ production expected from treatment with secretase inhibitors. These mice overexpress mutant APP from a vector that can be regulated b","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T259","span":{"begin":1,"end":9},"obj":"NNS"},{"id":"T260","span":{"begin":9,"end":155},"obj":"sentence"},{"id":"T261","span":{"begin":10,"end":12},"obj":"PRP"},{"id":"T262","span":{"begin":18,"end":27},"obj":"VBN"},{"id":"T263","span":{"begin":13,"end":17},"obj":"VBP"},{"id":"T264","span":{"begin":28,"end":29},"obj":"DT"},{"id":"T265","span":{"begin":47,"end":52},"obj":"NN"},{"id":"T266","span":{"begin":30,"end":40},"obj":"JJ"},{"id":"T267","span":{"begin":41,"end":46},"obj":"NN"},{"id":"T268","span":{"begin":53,"end":57},"obj":"WDT"},{"id":"T269","span":{"begin":70,"end":76},"obj":"VBZ"},{"id":"T270","span":{"begin":58,"end":69},"obj":"RB"},{"id":"T271","span":{"begin":77,"end":80},"obj":"DT"},{"id":"T272","span":{"begin":81,"end":87},"obj":"NN"},{"id":"T273","span":{"begin":88,"end":90},"obj":"IN"},{"id":"T274","span":{"begin":91,"end":93},"obj":"NN"},{"id":"T275","span":{"begin":94,"end":104},"obj":"NN"},{"id":"T276","span":{"begin":105,"end":113},"obj":"VBN"},{"id":"T277","span":{"begin":114,"end":118},"obj":"IN"},{"id":"T278","span":{"begin":119,"end":128},"obj":"NN"},{"id":"T279","span":{"begin":129,"end":133},"obj":"IN"},{"id":"T280","span":{"begin":134,"end":143},"obj":"NN"},{"id":"T281","span":{"begin":144,"end":154},"obj":"NNS"},{"id":"T282","span":{"begin":154,"end":155},"obj":"."},{"id":"T284","span":{"begin":156,"end":161},"obj":"DT"},{"id":"T285","span":{"begin":162,"end":166},"obj":"NNS"},{"id":"T286","span":{"begin":167,"end":178},"obj":"VBP"},{"id":"T287","span":{"begin":179,"end":185},"obj":"NN"},{"id":"T288","span":{"begin":186,"end":189},"obj":"NN"},{"id":"T289","span":{"begin":190,"end":194},"obj":"IN"},{"id":"T290","span":{"begin":195,"end":196},"obj":"DT"},{"id":"T291","span":{"begin":197,"end":203},"obj":"NN"},{"id":"T292","span":{"begin":204,"end":208},"obj":"WDT"},{"id":"T293","span":{"begin":216,"end":225},"obj":"VBN"},{"id":"T294","span":{"begin":209,"end":212},"obj":"MD"},{"id":"T295","span":{"begin":213,"end":215},"obj":"VB"}],"relations":[{"id":"R115","pred":"dobj","subj":"T265","obj":"T262"},{"id":"R116","pred":"amod","subj":"T266","obj":"T265"},{"id":"R117","pred":"compound","subj":"T267","obj":"T265"},{"id":"R119","pred":"relcl","subj":"T269","obj":"T265"},{"id":"R120","pred":"advmod","subj":"T270","obj":"T269"},{"id":"R141","pred":"relcl","subj":"T293","obj":"T291"},{"id":"R142","pred":"aux","subj":"T294","obj":"T293"},{"id":"R143","pred":"auxpass","subj":"T295","obj":"T293"},{"id":"R112","pred":"nsubj","subj":"T261","obj":"T262"},{"id":"R113","pred":"aux","subj":"T263","obj":"T262"},{"id":"R114","pred":"det","subj":"T264","obj":"T265"},{"id":"R118","pred":"dep","subj":"T268","obj":"T269"},{"id":"R121","pred":"det","subj":"T271","obj":"T272"},{"id":"R122","pred":"dobj","subj":"T272","obj":"T269"},{"id":"R123","pred":"prep","subj":"T273","obj":"T272"},{"id":"R124","pred":"compound","subj":"T274","obj":"T275"},{"id":"R125","pred":"pobj","subj":"T275","obj":"T273"},{"id":"R126","pred":"acl","subj":"T276","obj":"T275"},{"id":"R127","pred":"prep","subj":"T277","obj":"T276"},{"id":"R128","pred":"pobj","subj":"T278","obj":"T277"},{"id":"R129","pred":"prep","subj":"T279","obj":"T278"},{"id":"R130","pred":"compound","subj":"T280","obj":"T281"},{"id":"R131","pred":"pobj","subj":"T281","obj":"T279"},{"id":"R132","pred":"punct","subj":"T282","obj":"T262"},{"id":"R133","pred":"det","subj":"T284","obj":"T285"},{"id":"R134","pred":"nsubj","subj":"T285","obj":"T286"},{"id":"R135","pred":"compound","subj":"T287","obj":"T288"},{"id":"R136","pred":"dobj","subj":"T288","obj":"T286"},{"id":"R137","pred":"prep","subj":"T289","obj":"T286"},{"id":"R138","pred":"det","subj":"T290","obj":"T291"},{"id":"R139","pred":"pobj","subj":"T291","obj":"T289"},{"id":"R140","pred":"dep","subj":"T292","obj":"T293"}],"attributes":[{"subj":"T259","pred":"source","obj":"craft-sa-dev"},{"subj":"T260","pred":"source","obj":"craft-sa-dev"},{"subj":"T261","pred":"source","obj":"craft-sa-dev"},{"subj":"T262","pred":"source","obj":"craft-sa-dev"},{"subj":"T263","pred":"source","obj":"craft-sa-dev"},{"subj":"T264","pred":"source","obj":"craft-sa-dev"},{"subj":"T265","pred":"source","obj":"craft-sa-dev"},{"subj":"T266","pred":"source","obj":"craft-sa-dev"},{"subj":"T267","pred":"source","obj":"craft-sa-dev"},{"subj":"T268","pred":"source","obj":"craft-sa-dev"},{"subj":"T269","pred":"source","obj":"craft-sa-dev"},{"subj":"T270","pred":"source","obj":"craft-sa-dev"},{"subj":"T271","pred":"source","obj":"craft-sa-dev"},{"subj":"T272","pred":"source","obj":"craft-sa-dev"},{"subj":"T273","pred":"source","obj":"craft-sa-dev"},{"subj":"T274","pred":"source","obj":"craft-sa-dev"},{"subj":"T275","pred":"source","obj":"craft-sa-dev"},{"subj":"T276","pred":"source","obj":"craft-sa-dev"},{"subj":"T277","pred":"source","obj":"craft-sa-dev"},{"subj":"T278","pred":"source","obj":"craft-sa-dev"},{"subj":"T279","pred":"source","obj":"craft-sa-dev"},{"subj":"T280","pred":"source","obj":"craft-sa-dev"},{"subj":"T281","pred":"source","obj":"craft-sa-dev"},{"subj":"T282","pred":"source","obj":"craft-sa-dev"},{"subj":"T284","pred":"source","obj":"craft-sa-dev"},{"subj":"T285","pred":"source","obj":"craft-sa-dev"},{"subj":"T286","pred":"source","obj":"craft-sa-dev"},{"subj":"T287","pred":"source","obj":"craft-sa-dev"},{"subj":"T288","pred":"source","obj":"craft-sa-dev"},{"subj":"T289","pred":"source","obj":"craft-sa-dev"},{"subj":"T290","pred":"source","obj":"craft-sa-dev"},{"subj":"T291","pred":"source","obj":"craft-sa-dev"},{"subj":"T292","pred":"source","obj":"craft-sa-dev"},{"subj":"T293","pred":"source","obj":"craft-sa-dev"},{"subj":"T294","pred":"source","obj":"craft-sa-dev"},{"subj":"T295","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T96","span":{"begin":30,"end":40},"obj":"SO_EXT:transgenic_entity"},{"id":"T97","span":{"begin":41,"end":46},"obj":"NCBITaxon:10088"},{"id":"T98","span":{"begin":58,"end":69},"obj":"SO_EXT:0000704"},{"id":"T99","span":{"begin":91,"end":93},"obj":"CHEBI_PR_EXT:amyloid_beta"},{"id":"T100","span":{"begin":91,"end":104},"obj":"GO:0034205"},{"id":"T101","span":{"begin":144,"end":154},"obj":"CHEBI_EXT:35222"},{"id":"T102","span":{"begin":162,"end":166},"obj":"NCBITaxon:10088"},{"id":"T103","span":{"begin":171,"end":178},"obj":"GO:0010467"},{"id":"T104","span":{"begin":179,"end":185},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T105","span":{"begin":186,"end":189},"obj":"PR_EXT:000004168"},{"id":"T106","span":{"begin":197,"end":203},"obj":"SO_EXT:0000440"},{"id":"T107","span":{"begin":216,"end":225},"obj":"GO:0065007"}],"attributes":[{"subj":"T96","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T97","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T98","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T99","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T100","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T101","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T102","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T103","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T104","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T105","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T106","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T107","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T46","span":{"begin":41,"end":46},"obj":"NCBITaxon:10088"},{"id":"T47","span":{"begin":58,"end":69},"obj":"SO:0000704"},{"id":"T48","span":{"begin":91,"end":104},"obj":"GO:0034205"},{"id":"T49","span":{"begin":144,"end":154},"obj":"CHEBI:35222"},{"id":"T50","span":{"begin":162,"end":166},"obj":"NCBITaxon:10088"},{"id":"T51","span":{"begin":171,"end":178},"obj":"GO:0010467"},{"id":"T52","span":{"begin":186,"end":189},"obj":"PR:000004168"},{"id":"T53","span":{"begin":197,"end":203},"obj":"SO:0000440"},{"id":"T54","span":{"begin":216,"end":225},"obj":"GO:0065007"}],"attributes":[{"subj":"T46","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T47","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T48","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T49","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T50","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T51","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T52","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T53","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T54","pred":"source","obj":"craft-ca-core-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#93b5ec","default":true},{"id":"craft-ca-core-ex-dev","color":"#cfec93"},{"id":"craft-ca-core-dev","color":"#ec93e9"}]}]}}