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PMC:1283364 / 54993-55968 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T11779 0-5 VBN denotes Given
T11780 93-98 VBP denotes think
T11781 6-9 DT denotes the
T11782 27-31 NN denotes role
T11783 10-20 RB denotes relatively
T11784 21-26 JJ denotes minor
T11785 32-38 VBN denotes played
T11786 39-41 IN denotes by
T11787 42-51 NNS denotes microglia
T11788 52-54 IN denotes in
T11789 55-60 JJ denotes other
T11790 67-73 NNS denotes models
T11791 61-66 NN denotes mouse
T11792 74-76 IN denotes of
T11793 77-88 NN denotes amyloidosis
T11794 88-90 , denotes ,
T11795 90-92 PRP denotes we
T11796 99-101 PRP denotes it
T11797 102-110 JJ denotes unlikely
T11798 111-115 IN denotes that
T11799 133-143 VBN denotes influenced
T11800 116-121 DT denotes these
T11801 122-127 NNS denotes cells
T11802 128-132 VBP denotes have
T11803 144-147 DT denotes the
T11804 148-152 NN denotes rate
T11805 153-155 IN denotes of
T11806 156-163 NN denotes amyloid
T11807 164-173 NN denotes clearance
T11808 174-176 IN denotes in
T11809 177-180 DT denotes the
T11810 193-197 NNS denotes mice
T11811 181-184 NN denotes tet
T11812 185-188 NN denotes off
T11813 184-185 HYPH denotes -
T11814 189-192 NN denotes APP
T11815 197-198 . denotes .
T11816 198-336 sentence denotes Even so, we considered the possibility that chronic dox treatment may have altered the activation state of microglia in our treated mice.
T11817 199-203 RB denotes Even
T11818 204-206 RB denotes so
T11819 211-221 VBD denotes considered
T11820 206-208 , denotes ,
T11821 208-210 PRP denotes we
T11822 222-225 DT denotes the
T11823 226-237 NN denotes possibility
T11824 238-242 IN denotes that
T11825 274-281 VBN denotes altered
T11826 243-250 JJ denotes chronic
T11827 255-264 NN denotes treatment
T11828 251-254 NN denotes dox
T11829 265-268 MD denotes may
T11830 269-273 VB denotes have
T11831 282-285 DT denotes the
T11832 297-302 NN denotes state
T11833 286-296 NN denotes activation
T11834 303-305 IN denotes of
T11835 306-315 NNS denotes microglia
T11836 316-318 IN denotes in
T11837 319-322 PRP$ denotes our
T11838 331-335 NNS denotes mice
T11839 323-330 VBN denotes treated
T11840 335-336 . denotes .
T11841 336-459 sentence denotes Dox is structurally similar to minocycline, a reported anti-inflammatory drug and inhibitor of microglial activation [48].
T11842 337-340 NN denotes Dox
T11843 341-343 VBZ denotes is
T11844 344-356 RB denotes structurally
T11845 357-364 JJ denotes similar
T11846 365-367 IN denotes to
T11847 368-379 NN denotes minocycline
T11848 379-381 , denotes ,
T11849 381-382 DT denotes a
T11850 410-414 NN denotes drug
T11851 383-391 VBN denotes reported
T11852 392-409 JJ denotes anti-inflammatory
T11853 415-418 CC denotes and
T11854 419-428 NN denotes inhibitor
T11855 429-431 IN denotes of
T11856 432-442 JJ denotes microglial
T11857 443-453 NN denotes activation
T11858 454-455 -LRB- denotes [
T11859 455-457 CD denotes 48
T11860 457-458 -RRB- denotes ]
T11861 458-459 . denotes .
T11862 459-649 sentence denotes However, if dox does have anti-inflammatory activity, then, based on previous studies with other anti-inflammatories, we would have expected to find less amyloid in the dox-treated animals.
T11863 460-467 RB denotes However
T11864 592-600 VBN denotes expected
T11865 467-469 , denotes ,
T11866 469-471 IN denotes if
T11867 481-485 VB denotes have
T11868 472-475 NN denotes dox
T11869 476-480 VBZ denotes does
T11870 486-503 JJ denotes anti-inflammatory
T11871 504-512 NN denotes activity
T11872 512-514 , denotes ,
T11873 514-518 RB denotes then
T11874 518-520 , denotes ,
T11875 520-525 VBN denotes based
T11876 526-528 IN denotes on
T11877 529-537 JJ denotes previous
T11878 538-545 NNS denotes studies
T11879 546-550 IN denotes with
T11880 551-556 JJ denotes other
T11881 557-576 NNS denotes anti-inflammatories
T11882 576-578 , denotes ,
T11883 578-580 PRP denotes we
T11884 581-586 MD denotes would
T11885 587-591 VB denotes have
T11886 601-603 TO denotes to
T11887 604-608 VB denotes find
T11888 609-613 RBR denotes less
T11889 614-621 NN denotes amyloid
T11890 622-624 IN denotes in
T11891 625-628 DT denotes the
T11892 641-648 NNS denotes animals
T11893 629-632 NN denotes dox
T11894 633-640 VBN denotes treated
T11895 632-633 HYPH denotes -
T11896 648-649 . denotes .
T11897 649-681 sentence denotes Clearly, that was not the case.
T11898 650-657 RB denotes Clearly
T11899 664-667 VBD denotes was
T11900 657-659 , denotes ,
T11901 659-663 DT denotes that
T11902 668-671 RB denotes not
T11903 672-675 DT denotes the
T11904 676-680 NN denotes case
T11905 680-681 . denotes .
T11906 681-975 sentence denotes While it is possible that dox acts in some other way to slow amyloid clearance, data from multiple studies demonstrate that microglial responses are normally weak in the mouse AD models [37–40], and thus it is doubtful that dox-mediated microglial inhibition affected the outcome of our study.
T11907 682-687 IN denotes While
T11908 691-693 VBZ denotes is
T11909 688-690 PRP denotes it
T11910 789-800 VBP denotes demonstrate
T11911 694-702 JJ denotes possible
T11912 703-707 IN denotes that
T11913 712-716 VBZ denotes acts
T11914 708-711 NN denotes dox
T11915 717-719 IN denotes in
T11916 720-724 DT denotes some
T11917 731-734 NN denotes way
T11918 725-730 JJ denotes other
T11919 735-737 TO denotes to
T11920 738-742 VB denotes slow
T11921 743-750 NN denotes amyloid
T11922 751-760 NN denotes clearance
T11923 760-762 , denotes ,
T11924 762-766 NNS denotes data
T11925 767-771 IN denotes from
T11926 772-780 JJ denotes multiple
T11927 781-788 NNS denotes studies
T11928 801-805 IN denotes that
T11929 827-830 VBP denotes are
T11930 806-816 JJ denotes microglial
T11931 817-826 NNS denotes responses
T11932 831-839 RB denotes normally
T11933 840-844 JJ denotes weak
T11934 845-847 IN denotes in
T11935 848-851 DT denotes the
T11936 861-867 NNS denotes models
T11937 852-857 NN denotes mouse
T11938 858-860 NN denotes AD
T11939 868-869 -LRB- denotes [
T11940 869-871 CD denotes 37
T11941 871-872 SYM denotes –
T11942 872-874 CD denotes 40
T11943 874-875 -RRB- denotes ]
T11944 875-877 , denotes ,
T11945 877-880 CC denotes and
T11946 881-885 RB denotes thus
T11947 889-891 VBZ denotes is
T11948 886-888 PRP denotes it
T11949 892-900 JJ denotes doubtful
T11950 901-905 IN denotes that
T11951 941-949 VBD denotes affected
T11952 906-909 NN denotes dox
T11953 910-918 VBN denotes mediated
T11954 909-910 HYPH denotes -
T11955 930-940 NN denotes inhibition
T11956 919-929 JJ denotes microglial
T11957 950-953 DT denotes the
T11958 954-961 NN denotes outcome
T11959 962-964 IN denotes of
T11960 965-968 PRP$ denotes our
T11961 969-974 NN denotes study
T11962 974-975 . denotes .
R8150 T11779 T11780 prep Given,think
R8151 T11781 T11782 det the,role
R8152 T11782 T11779 pobj role,Given
R8153 T11783 T11784 advmod relatively,minor
R8154 T11784 T11782 amod minor,role
R8155 T11785 T11782 acl played,role
R8156 T11786 T11785 agent by,played
R8157 T11787 T11786 pobj microglia,by
R8158 T11788 T11785 prep in,played
R8159 T11789 T11790 amod other,models
R8160 T11790 T11788 pobj models,in
R8161 T11791 T11790 compound mouse,models
R8162 T11792 T11790 prep of,models
R8163 T11793 T11792 pobj amyloidosis,of
R8164 T11794 T11780 punct ", ",think
R8165 T11795 T11780 nsubj we,think
R8166 T11796 T11797 nsubj it,unlikely
R8167 T11797 T11780 advcl unlikely,think
R8168 T11798 T11799 mark that,influenced
R8169 T11799 T11797 advcl influenced,unlikely
R8170 T11800 T11801 det these,cells
R8171 T11801 T11799 nsubj cells,influenced
R8172 T11802 T11799 aux have,influenced
R8173 T11803 T11804 det the,rate
R8174 T11804 T11799 dobj rate,influenced
R8175 T11805 T11804 prep of,rate
R8176 T11806 T11807 compound amyloid,clearance
R8177 T11807 T11805 pobj clearance,of
R8178 T11808 T11799 prep in,influenced
R8179 T11809 T11810 det the,mice
R8180 T11810 T11808 pobj mice,in
R8181 T11811 T11812 compound tet,off
R8182 T11812 T11810 compound off,mice
R8183 T11813 T11812 punct -,off
R8184 T11814 T11810 compound APP,mice
R8185 T11815 T11780 punct .,think
R8186 T11817 T11818 advmod Even,so
R8187 T11818 T11819 advmod so,considered
R8188 T11820 T11819 punct ", ",considered
R8189 T11821 T11819 nsubj we,considered
R8190 T11822 T11823 det the,possibility
R8191 T11823 T11819 dobj possibility,considered
R8192 T11824 T11825 mark that,altered
R8193 T11825 T11823 acl altered,possibility
R8194 T11826 T11827 amod chronic,treatment
R8195 T11827 T11825 nsubj treatment,altered
R8196 T11828 T11827 compound dox,treatment
R8197 T11829 T11825 aux may,altered
R8198 T11830 T11825 aux have,altered
R8199 T11831 T11832 det the,state
R8200 T11832 T11825 dobj state,altered
R8201 T11833 T11832 compound activation,state
R8202 T11834 T11832 prep of,state
R8203 T11835 T11834 pobj microglia,of
R8204 T11836 T11825 prep in,altered
R8205 T11837 T11838 poss our,mice
R8206 T11838 T11836 pobj mice,in
R8207 T11839 T11838 amod treated,mice
R8208 T11840 T11819 punct .,considered
R8209 T11842 T11843 nsubj Dox,is
R8210 T11844 T11845 advmod structurally,similar
R8211 T11845 T11843 acomp similar,is
R8212 T11846 T11845 prep to,similar
R8213 T11847 T11846 pobj minocycline,to
R8214 T11848 T11847 punct ", ",minocycline
R8215 T11849 T11850 det a,drug
R8216 T11850 T11847 appos drug,minocycline
R8217 T11851 T11850 amod reported,drug
R8218 T11852 T11850 amod anti-inflammatory,drug
R8219 T11853 T11850 cc and,drug
R8220 T11854 T11850 conj inhibitor,drug
R8221 T11855 T11854 prep of,inhibitor
R8222 T11856 T11857 amod microglial,activation
R8223 T11857 T11855 pobj activation,of
R8224 T11858 T11859 punct [,48
R8225 T11859 T11843 parataxis 48,is
R8226 T11860 T11859 punct ],48
R8227 T11861 T11843 punct .,is
R8228 T11863 T11864 advmod However,expected
R8229 T11865 T11864 punct ", ",expected
R8230 T11866 T11867 mark if,have
R8231 T11867 T11864 advcl have,expected
R8232 T11868 T11867 nsubj dox,have
R8233 T11869 T11867 aux does,have
R8234 T11870 T11871 amod anti-inflammatory,activity
R8235 T11871 T11867 dobj activity,have
R8236 T11872 T11864 punct ", ",expected
R8237 T11873 T11864 advmod then,expected
R8238 T11874 T11864 punct ", ",expected
R8239 T11875 T11864 prep based,expected
R8240 T11876 T11875 prep on,based
R8241 T11877 T11878 amod previous,studies
R8242 T11878 T11876 pobj studies,on
R8243 T11879 T11878 prep with,studies
R8244 T11880 T11881 amod other,anti-inflammatories
R8245 T11881 T11879 pobj anti-inflammatories,with
R8246 T11882 T11864 punct ", ",expected
R8247 T11883 T11864 nsubj we,expected
R8248 T11884 T11864 aux would,expected
R8249 T11885 T11864 aux have,expected
R8250 T11886 T11887 aux to,find
R8251 T11887 T11864 xcomp find,expected
R8252 T11888 T11889 advmod less,amyloid
R8253 T11889 T11887 dobj amyloid,find
R8254 T11890 T11887 prep in,find
R8255 T11891 T11892 det the,animals
R8256 T11892 T11890 pobj animals,in
R8257 T11893 T11894 npadvmod dox,treated
R8258 T11894 T11892 amod treated,animals
R8259 T11895 T11894 punct -,treated
R8260 T11896 T11864 punct .,expected
R8261 T11898 T11899 advmod Clearly,was
R8262 T11900 T11899 punct ", ",was
R8263 T11901 T11899 nsubj that,was
R8264 T11902 T11899 neg not,was
R8265 T11903 T11904 det the,case
R8266 T11904 T11899 attr case,was
R8267 T11905 T11899 punct .,was
R8268 T11907 T11908 mark While,is
R8269 T11908 T11910 advcl is,demonstrate
R8270 T11909 T11908 nsubj it,is
R8271 T11911 T11908 acomp possible,is
R8272 T11912 T11913 mark that,acts
R8273 T11913 T11908 ccomp acts,is
R8274 T11914 T11913 nsubj dox,acts
R8275 T11915 T11913 prep in,acts
R8276 T11916 T11917 det some,way
R8277 T11917 T11915 pobj way,in
R8278 T11918 T11917 amod other,way
R8279 T11919 T11920 aux to,slow
R8280 T11920 T11913 advcl slow,acts
R8281 T11921 T11922 compound amyloid,clearance
R8282 T11922 T11920 dobj clearance,slow
R8283 T11923 T11910 punct ", ",demonstrate
R8284 T11924 T11910 nsubj data,demonstrate
R8285 T11925 T11924 prep from,data
R8286 T11926 T11927 amod multiple,studies
R8287 T11927 T11925 pobj studies,from
R8288 T11928 T11929 mark that,are
R8289 T11929 T11910 ccomp are,demonstrate
R8290 T11930 T11931 amod microglial,responses
R8291 T11931 T11929 nsubj responses,are
R8292 T11932 T11929 advmod normally,are
R8293 T11933 T11929 acomp weak,are
R8294 T11934 T11929 prep in,are
R8295 T11935 T11936 det the,models
R8296 T11936 T11934 pobj models,in
R8297 T11937 T11936 compound mouse,models
R8298 T11938 T11936 compound AD,models
R8299 T11939 T11940 punct [,37
R8300 T11940 T11929 parataxis 37,are
R8301 T11941 T11942 punct –,40
R8302 T11942 T11940 prep 40,37
R8303 T11943 T11940 punct ],37
R8304 T11944 T11929 punct ", ",are
R8305 T11945 T11929 cc and,are
R8306 T11946 T11947 advmod thus,is
R8307 T11947 T11929 conj is,are
R8308 T11948 T11947 nsubj it,is
R8309 T11949 T11947 acomp doubtful,is
R8310 T11950 T11951 mark that,affected
R8311 T11951 T11947 ccomp affected,is
R8312 T11952 T11953 npadvmod dox,mediated
R8313 T11953 T11955 amod mediated,inhibition
R8314 T11954 T11953 punct -,mediated
R8315 T11955 T11951 nsubj inhibition,affected
R8316 T11956 T11955 amod microglial,inhibition
R8317 T11957 T11958 det the,outcome
R8318 T11958 T11951 dobj outcome,affected
R8319 T11959 T11958 prep of,outcome
R8320 T11960 T11961 poss our,study
R8321 T11961 T11959 pobj study,of
R8322 T11962 T11910 punct .,demonstrate

2_test

Id Subject Object Predicate Lexical cue
16279840-9861045-86242787 455-457 9861045 denotes 48
16279840-12404061-86242788 869-871 12404061 denotes 37
16279840-15353209-86242788 869-871 15353209 denotes 37
16279840-11164276-86242788 869-871 11164276 denotes 37
16279840-15191802-86242788 869-871 15191802 denotes 37
T6243 455-457 9861045 denotes 48
T28273 869-871 12404061 denotes 37
T59342 869-871 15353209 denotes 37
T92299 869-871 11164276 denotes 37
T40804 869-871 15191802 denotes 37

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T10372 42-51 CL:0000129 denotes microglia
T10373 61-66 NCBITaxon:10088 denotes mouse
T10374 122-127 CL_GO_EXT:cell denotes cells
T10375 156-163 CHEBI:60425 denotes amyloid
T10376 189-192 PR_EXT:000004168 denotes APP
T10377 193-197 NCBITaxon:10088 denotes mice
T10378 251-254 CHEBI:50845 denotes dox
T10379 306-315 CL:0000129 denotes microglia
T10380 331-335 NCBITaxon:10088 denotes mice
T10381 337-340 CHEBI:50845 denotes Dox
T10382 368-379 CHEBI:50694 denotes minocycline
T10383 392-414 CHEBI_EXT:35472 denotes anti-inflammatory drug
T10384 397-409 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T10385 419-428 CHEBI_EXT:35222 denotes inhibitor
T10386 432-442 CL:0000129 denotes microglial
T10387 432-453 GO:0001774 denotes microglial activation
T10388 472-475 CHEBI:50845 denotes dox
T10389 491-503 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T10390 557-576 CHEBI_EXT:67079 denotes anti-inflammatories
T10392 629-632 CHEBI:50845 denotes dox
T10393 641-648 NCBITaxon:33208 denotes animals
T10394 708-711 CHEBI:50845 denotes dox
T10395 743-750 CHEBI:60425 denotes amyloid
T10396 806-816 CL:0000129 denotes microglial
T10397 817-826 GO_EXT:reaction_or_response denotes responses
T10398 852-857 NCBITaxon:10088 denotes mouse
T10399 906-909 CHEBI:50845 denotes dox
T10400 919-929 CL:0000129 denotes microglial
T10391 614-621 CHEBI:60425 denotes amyloid

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T10068 42-51 CL:0000129 denotes microglia
T10069 61-66 NCBITaxon:10088 denotes mouse
T10070 156-163 CHEBI:60425 denotes amyloid
T10071 189-192 PR:000004168 denotes APP
T10072 193-197 NCBITaxon:10088 denotes mice
T10073 251-254 CHEBI:50845 denotes dox
T10074 306-315 CL:0000129 denotes microglia
T10075 331-335 NCBITaxon:10088 denotes mice
T10076 337-340 CHEBI:50845 denotes Dox
T10077 368-379 CHEBI:50694 denotes minocycline
T10078 392-414 CHEBI:35472 denotes anti-inflammatory drug
T10079 419-428 CHEBI:35222 denotes inhibitor
T10080 432-442 CL:0000129 denotes microglial
T10081 432-453 GO:0001774 denotes microglial activation
T10082 472-475 CHEBI:50845 denotes dox
T10083 557-576 CHEBI:67079 denotes anti-inflammatories
T10084 614-621 CHEBI:60425 denotes amyloid
T10085 629-632 CHEBI:50845 denotes dox
T10086 641-648 NCBITaxon:33208 denotes animals
T10087 708-711 CHEBI:50845 denotes dox
T10088 743-750 CHEBI:60425 denotes amyloid
T10089 806-816 CL:0000129 denotes microglial
T10090 852-857 NCBITaxon:10088 denotes mouse
T10091 906-909 CHEBI:50845 denotes dox
T10092 919-929 CL:0000129 denotes microglial