PMC:1283364 / 5082-5482 JSONTXT

Annnotations TAB JSON ListView MergeView

    craft-sa-dev

    {"project":"craft-sa-dev","denotations":[{"id":"T1262","span":{"begin":0,"end":400},"obj":"sentence"},{"id":"T1263","span":{"begin":1,"end":4},"obj":"DT"},{"id":"T1264","span":{"begin":23,"end":29},"obj":"NNS"},{"id":"T1265","span":{"begin":5,"end":11},"obj":"JJ"},{"id":"T1266","span":{"begin":12,"end":22},"obj":"NN"},{"id":"T1267","span":{"begin":172,"end":179},"obj":"VBD"},{"id":"T1268","span":{"begin":30,"end":38},"obj":"VBN"},{"id":"T1269","span":{"begin":39,"end":43},"obj":"IN"},{"id":"T1270","span":{"begin":44,"end":47},"obj":"DT"},{"id":"T1271","span":{"begin":56,"end":63},"obj":"NNS"},{"id":"T1272","span":{"begin":48,"end":51},"obj":"NN"},{"id":"T1273","span":{"begin":52,"end":55},"obj":"NN"},{"id":"T1274","span":{"begin":51,"end":52},"obj":"HYPH"},{"id":"T1275","span":{"begin":63,"end":65},"obj":","},{"id":"T1276","span":{"begin":65,"end":73},"obj":"VBN"},{"id":"T1277","span":{"begin":74,"end":78},"obj":"IN"},{"id":"T1278","span":{"begin":79,"end":82},"obj":"DT"},{"id":"T1279","span":{"begin":83,"end":90},"obj":"NN"},{"id":"T1280","span":{"begin":91,"end":93},"obj":"TO"},{"id":"T1281","span":{"begin":94,"end":100},"obj":"VB"},{"id":"T1282","span":{"begin":101,"end":105},"obj":"DT"},{"id":"T1283","span":{"begin":106,"end":116},"obj":"NN"},{"id":"T1284","span":{"begin":117,"end":119},"obj":"IN"},{"id":"T1285","span":{"begin":120,"end":127},"obj":"JJ"},{"id":"T1286","span":{"begin":128,"end":134},"obj":"NNS"},{"id":"T1287","span":{"begin":135,"end":137},"obj":"IN"},{"id":"T1288","span":{"begin":138,"end":147},"obj":"NN"},{"id":"T1289","span":{"begin":148,"end":152},"obj":"IN"},{"id":"T1290","span":{"begin":153,"end":165},"obj":"NN"},{"id":"T1291","span":{"begin":166,"end":167},"obj":"-LRB-"},{"id":"T1292","span":{"begin":167,"end":169},"obj":"CD"},{"id":"T1293","span":{"begin":169,"end":170},"obj":"-RRB-"},{"id":"T1294","span":{"begin":170,"end":172},"obj":","},{"id":"T1295","span":{"begin":180,"end":183},"obj":"IN"},{"id":"T1296","span":{"begin":184,"end":185},"obj":"DT"},{"id":"T1297","span":{"begin":196,"end":200},"obj":"NN"},{"id":"T1298","span":{"begin":186,"end":195},"obj":"JJ"},{"id":"T1299","span":{"begin":201,"end":203},"obj":"IN"},{"id":"T1300","span":{"begin":204,"end":207},"obj":"WRB"},{"id":"T1301","span":{"begin":275,"end":281},"obj":"VB"},{"id":"T1302","span":{"begin":208,"end":209},"obj":"DT"},{"id":"T1303","span":{"begin":242,"end":251},"obj":"NN"},{"id":"T1304","span":{"begin":210,"end":216},"obj":"RB"},{"id":"T1305","span":{"begin":217,"end":226},"obj":"JJ"},{"id":"T1306","span":{"begin":227,"end":241},"obj":"JJ"},{"id":"T1307","span":{"begin":252,"end":254},"obj":"IN"},{"id":"T1308","span":{"begin":255,"end":257},"obj":"NN"},{"id":"T1309","span":{"begin":258,"end":268},"obj":"NN"},{"id":"T1310","span":{"begin":269,"end":274},"obj":"MD"},{"id":"T1311","span":{"begin":282,"end":285},"obj":"DT"},{"id":"T1312","span":{"begin":286,"end":297},"obj":"NN"},{"id":"T1313","span":{"begin":298,"end":300},"obj":"IN"},{"id":"T1314","span":{"begin":301,"end":308},"obj":"NN"},{"id":"T1315","span":{"begin":309,"end":318},"obj":"NN"},{"id":"T1316","span":{"begin":319,"end":322},"obj":"CC"},{"id":"T1317","span":{"begin":323,"end":330},"obj":"IN"},{"id":"T1318","span":{"begin":363,"end":365},"obj":"VB"},{"id":"T1319","span":{"begin":331,"end":339},"obj":"NN"},{"id":"T1320","span":{"begin":340,"end":342},"obj":"IN"},{"id":"T1321","span":{"begin":343,"end":348},"obj":"DT"},{"id":"T1322","span":{"begin":349,"end":356},"obj":"NNS"},{"id":"T1323","span":{"begin":357,"end":362},"obj":"MD"},{"id":"T1324","span":{"begin":366,"end":374},"obj":"JJ"},{"id":"T1325","span":{"begin":375,"end":384},"obj":"VBG"},{"id":"T1326","span":{"begin":385,"end":389},"obj":"JJ"},{"id":"T1327","span":{"begin":390,"end":399},"obj":"NN"},{"id":"T1328","span":{"begin":399,"end":400},"obj":"."}],"relations":[{"id":"R850","pred":"det","subj":"T1263","obj":"T1264"},{"id":"R851","pred":"nsubj","subj":"T1264","obj":"T1267"},{"id":"R852","pred":"amod","subj":"T1265","obj":"T1264"},{"id":"R853","pred":"compound","subj":"T1266","obj":"T1264"},{"id":"R854","pred":"acl","subj":"T1268","obj":"T1264"},{"id":"R855","pred":"prep","subj":"T1269","obj":"T1268"},{"id":"R856","pred":"det","subj":"T1270","obj":"T1271"},{"id":"R857","pred":"pobj","subj":"T1271","obj":"T1269"},{"id":"R858","pred":"compound","subj":"T1272","obj":"T1273"},{"id":"R859","pred":"compound","subj":"T1273","obj":"T1271"},{"id":"R860","pred":"punct","subj":"T1274","obj":"T1273"},{"id":"R861","pred":"punct","subj":"T1275","obj":"T1271"},{"id":"R862","pred":"acl","subj":"T1276","obj":"T1271"},{"id":"R863","pred":"prep","subj":"T1277","obj":"T1276"},{"id":"R864","pred":"det","subj":"T1278","obj":"T1279"},{"id":"R865","pred":"pobj","subj":"T1279","obj":"T1277"},{"id":"R866","pred":"aux","subj":"T1280","obj":"T1281"},{"id":"R867","pred":"acl","subj":"T1281","obj":"T1279"},{"id":"R868","pred":"det","subj":"T1282","obj":"T1283"},{"id":"R869","pred":"dobj","subj":"T1283","obj":"T1281"},{"id":"R870","pred":"prep","subj":"T1284","obj":"T1281"},{"id":"R871","pred":"amod","subj":"T1285","obj":"T1286"},{"id":"R872","pred":"pobj","subj":"T1286","obj":"T1284"},{"id":"R873","pred":"prep","subj":"T1287","obj":"T1286"},{"id":"R874","pred":"pobj","subj":"T1288","obj":"T1287"},{"id":"R875","pred":"prep","subj":"T1289","obj":"T1281"},{"id":"R876","pred":"pobj","subj":"T1290","obj":"T1289"},{"id":"R877","pred":"punct","subj":"T1291","obj":"T1292"},{"id":"R878","pred":"parataxis","subj":"T1292","obj":"T1281"},{"id":"R879","pred":"punct","subj":"T1293","obj":"T1292"},{"id":"R880","pred":"punct","subj":"T1294","obj":"T1267"},{"id":"R881","pred":"prep","subj":"T1295","obj":"T1267"},{"id":"R882","pred":"det","subj":"T1296","obj":"T1297"},{"id":"R883","pred":"pobj","subj":"T1297","obj":"T1295"},{"id":"R884","pred":"amod","subj":"T1298","obj":"T1297"},{"id":"R885","pred":"prep","subj":"T1299","obj":"T1297"},{"id":"R886","pred":"advmod","subj":"T1300","obj":"T1301"},{"id":"R887","pred":"pobj","subj":"T1301","obj":"T1299"},{"id":"R888","pred":"det","subj":"T1302","obj":"T1303"},{"id":"R889","pred":"nsubj","subj":"T1303","obj":"T1301"},{"id":"R890","pred":"advmod","subj":"T1304","obj":"T1305"},{"id":"R891","pred":"amod","subj":"T1305","obj":"T1303"},{"id":"R892","pred":"amod","subj":"T1306","obj":"T1303"},{"id":"R893","pred":"prep","subj":"T1307","obj":"T1303"},{"id":"R894","pred":"compound","subj":"T1308","obj":"T1309"},{"id":"R895","pred":"pobj","subj":"T1309","obj":"T1307"},{"id":"R896","pred":"aux","subj":"T1310","obj":"T1301"},{"id":"R897","pred":"det","subj":"T1311","obj":"T1312"},{"id":"R898","pred":"dobj","subj":"T1312","obj":"T1301"},{"id":"R899","pred":"prep","subj":"T1313","obj":"T1312"},{"id":"R900","pred":"compound","subj":"T1314","obj":"T1315"},{"id":"R901","pred":"pobj","subj":"T1315","obj":"T1313"},{"id":"R902","pred":"cc","subj":"T1316","obj":"T1301"},{"id":"R903","pred":"mark","subj":"T1317","obj":"T1318"},{"id":"R904","pred":"conj","subj":"T1318","obj":"T1301"},{"id":"R905","pred":"nsubj","subj":"T1319","obj":"T1318"},{"id":"R906","pred":"prep","subj":"T1320","obj":"T1319"},{"id":"R907","pred":"det","subj":"T1321","obj":"T1322"},{"id":"R908","pred":"pobj","subj":"T1322","obj":"T1320"},{"id":"R909","pred":"aux","subj":"T1323","obj":"T1318"},{"id":"R910","pred":"acomp","subj":"T1324","obj":"T1318"},{"id":"R911","pred":"prep","subj":"T1325","obj":"T1318"},{"id":"R912","pred":"prep","subj":"T1326","obj":"T1325"},{"id":"R913","pred":"pobj","subj":"T1327","obj":"T1326"},{"id":"R914","pred":"punct","subj":"T1328","obj":"T1267"}],"text":" The strong expression levels produced with the tet-off vectors, combined with the ability to reduce this expression by several orders of magnitude with tetracycline [14], allowed for a stringent test of how a highly effective pharmaceutical inhibitor of Aβ production would impact the progression of amyloid pathology and whether reversal of these lesions might be possible following such treatment."}

    2_test

    {"project":"2_test","denotations":[{"id":"16279840-8855286-86242753","span":{"begin":167,"end":169},"obj":"8855286"},{"id":"T70705","span":{"begin":167,"end":169},"obj":"8855286"}],"text":" The strong expression levels produced with the tet-off vectors, combined with the ability to reduce this expression by several orders of magnitude with tetracycline [14], allowed for a stringent test of how a highly effective pharmaceutical inhibitor of Aβ production would impact the progression of amyloid pathology and whether reversal of these lesions might be possible following such treatment."}

    craft-ca-core-ex-dev

    {"project":"craft-ca-core-ex-dev","denotations":[{"id":"T697","span":{"begin":12,"end":22},"obj":"GO:0010467"},{"id":"T698","span":{"begin":56,"end":63},"obj":"SO_EXT:0000440"},{"id":"T699","span":{"begin":106,"end":116},"obj":"GO:0010467"},{"id":"T700","span":{"begin":153,"end":165},"obj":"CHEBI:27902"},{"id":"T701","span":{"begin":227,"end":241},"obj":"CHEBI_EXT:52217"},{"id":"T702","span":{"begin":242,"end":251},"obj":"CHEBI_EXT:35222"},{"id":"T703","span":{"begin":255,"end":257},"obj":"CHEBI_PR_EXT:amyloid_beta"},{"id":"T704","span":{"begin":255,"end":268},"obj":"GO:0034205"},{"id":"T705","span":{"begin":301,"end":308},"obj":"CHEBI:60425"}],"text":" The strong expression levels produced with the tet-off vectors, combined with the ability to reduce this expression by several orders of magnitude with tetracycline [14], allowed for a stringent test of how a highly effective pharmaceutical inhibitor of Aβ production would impact the progression of amyloid pathology and whether reversal of these lesions might be possible following such treatment."}

    craft-ca-core-dev

    {"project":"craft-ca-core-dev","denotations":[{"id":"T603","span":{"begin":12,"end":22},"obj":"GO:0010467"},{"id":"T604","span":{"begin":56,"end":63},"obj":"SO:0000440"},{"id":"T605","span":{"begin":106,"end":116},"obj":"GO:0010467"},{"id":"T606","span":{"begin":153,"end":165},"obj":"CHEBI:27902"},{"id":"T607","span":{"begin":227,"end":241},"obj":"CHEBI:52217"},{"id":"T608","span":{"begin":242,"end":251},"obj":"CHEBI:35222"},{"id":"T609","span":{"begin":255,"end":268},"obj":"GO:0034205"},{"id":"T610","span":{"begin":301,"end":308},"obj":"CHEBI:60425"}],"text":" The strong expression levels produced with the tet-off vectors, combined with the ability to reduce this expression by several orders of magnitude with tetracycline [14], allowed for a stringent test of how a highly effective pharmaceutical inhibitor of Aβ production would impact the progression of amyloid pathology and whether reversal of these lesions might be possible following such treatment."}