Id |
Subject |
Object |
Predicate |
Lexical cue |
T10541 |
0-2 |
PRP |
denotes |
We |
T10542 |
3-10 |
VBP |
denotes |
present |
T10543 |
11-12 |
DT |
denotes |
a |
T10544 |
23-28 |
NN |
denotes |
model |
T10545 |
13-16 |
JJ |
denotes |
new |
T10546 |
17-22 |
NN |
denotes |
mouse |
T10547 |
29-32 |
IN |
denotes |
for |
T10548 |
33-35 |
NN |
denotes |
AD |
T10549 |
36-40 |
WDT |
denotes |
that |
T10550 |
45-53 |
VBN |
denotes |
designed |
T10551 |
41-44 |
VBD |
denotes |
was |
T10552 |
54-56 |
TO |
denotes |
to |
T10553 |
57-61 |
VB |
denotes |
test |
T10554 |
62-65 |
DT |
denotes |
the |
T10555 |
66-78 |
NNS |
denotes |
consequences |
T10556 |
79-81 |
IN |
denotes |
of |
T10557 |
82-92 |
VBG |
denotes |
inhibiting |
T10558 |
93-95 |
NN |
denotes |
Aβ |
T10559 |
96-106 |
NN |
denotes |
production |
T10560 |
107-112 |
IN |
denotes |
after |
T10561 |
113-116 |
DT |
denotes |
the |
T10562 |
117-122 |
NN |
denotes |
onset |
T10563 |
123-125 |
IN |
denotes |
of |
T10564 |
126-133 |
NN |
denotes |
amyloid |
T10565 |
134-143 |
NN |
denotes |
pathology |
T10566 |
143-144 |
. |
denotes |
. |
T10567 |
144-299 |
sentence |
denotes |
New lines of transgenic mice were developed for this study that express high levels of APPswe/ind under the control of a tetracycline-responsive promoter. |
T10568 |
145-148 |
JJ |
denotes |
New |
T10569 |
149-154 |
NNS |
denotes |
lines |
T10570 |
179-188 |
VBN |
denotes |
developed |
T10571 |
155-157 |
IN |
denotes |
of |
T10572 |
158-168 |
JJ |
denotes |
transgenic |
T10573 |
169-173 |
NNS |
denotes |
mice |
T10574 |
174-178 |
VBD |
denotes |
were |
T10575 |
189-192 |
IN |
denotes |
for |
T10576 |
193-197 |
DT |
denotes |
this |
T10577 |
198-203 |
NN |
denotes |
study |
T10578 |
204-208 |
WDT |
denotes |
that |
T10579 |
209-216 |
VBP |
denotes |
express |
T10580 |
217-221 |
JJ |
denotes |
high |
T10581 |
222-228 |
NNS |
denotes |
levels |
T10582 |
229-231 |
IN |
denotes |
of |
T10583 |
232-238 |
NN |
denotes |
APPswe |
T10584 |
239-242 |
NN |
denotes |
ind |
T10585 |
238-239 |
HYPH |
denotes |
/ |
T10586 |
243-248 |
IN |
denotes |
under |
T10587 |
249-252 |
DT |
denotes |
the |
T10588 |
253-260 |
NN |
denotes |
control |
T10589 |
261-263 |
IN |
denotes |
of |
T10590 |
264-265 |
DT |
denotes |
a |
T10591 |
290-298 |
NN |
denotes |
promoter |
T10592 |
266-278 |
NN |
denotes |
tetracycline |
T10593 |
279-289 |
JJ |
denotes |
responsive |
T10594 |
278-279 |
HYPH |
denotes |
- |
T10595 |
298-299 |
. |
denotes |
. |
T10596 |
299-497 |
sentence |
denotes |
We demonstrate that treatment with dox suppresses steady-state levels of both APPswe/ind and its C-terminal fragments, indicating that the mutant proteins have a relatively short half-life in vivo. |
T10597 |
300-302 |
PRP |
denotes |
We |
T10598 |
303-314 |
VBP |
denotes |
demonstrate |
T10599 |
315-319 |
IN |
denotes |
that |
T10600 |
339-349 |
VBZ |
denotes |
suppresses |
T10601 |
320-329 |
NN |
denotes |
treatment |
T10602 |
330-334 |
IN |
denotes |
with |
T10603 |
335-338 |
NN |
denotes |
dox |
T10604 |
350-356 |
JJ |
denotes |
steady |
T10605 |
357-362 |
NN |
denotes |
state |
T10606 |
356-357 |
HYPH |
denotes |
- |
T10607 |
363-369 |
NNS |
denotes |
levels |
T10608 |
370-372 |
IN |
denotes |
of |
T10609 |
373-377 |
CC |
denotes |
both |
T10610 |
385-388 |
NN |
denotes |
ind |
T10611 |
378-384 |
NN |
denotes |
APPswe |
T10612 |
384-385 |
HYPH |
denotes |
/ |
T10613 |
389-392 |
CC |
denotes |
and |
T10614 |
393-396 |
PRP$ |
denotes |
its |
T10615 |
408-417 |
NNS |
denotes |
fragments |
T10616 |
397-398 |
NN |
denotes |
C |
T10617 |
398-399 |
HYPH |
denotes |
- |
T10618 |
399-407 |
JJ |
denotes |
terminal |
T10619 |
417-419 |
, |
denotes |
, |
T10620 |
419-429 |
VBG |
denotes |
indicating |
T10621 |
430-434 |
IN |
denotes |
that |
T10622 |
455-459 |
VBP |
denotes |
have |
T10623 |
435-438 |
DT |
denotes |
the |
T10624 |
446-454 |
NN |
denotes |
proteins |
T10625 |
439-445 |
NN |
denotes |
mutant |
T10626 |
460-461 |
DT |
denotes |
a |
T10627 |
484-488 |
NN |
denotes |
life |
T10628 |
462-472 |
RB |
denotes |
relatively |
T10629 |
473-478 |
JJ |
denotes |
short |
T10630 |
479-483 |
NN |
denotes |
half |
T10631 |
483-484 |
HYPH |
denotes |
- |
T10632 |
489-491 |
FW |
denotes |
in |
T10633 |
492-496 |
FW |
denotes |
vivo |
T10634 |
496-497 |
. |
denotes |
. |
T10635 |
497-677 |
sentence |
denotes |
Transgenic expression of APPswe/ind and consequent overproduction of Aβ42 cause early-onset amyloid deposition in untreated mice, in which deposits appear as early as 2 mo of age. |
T10636 |
498-508 |
JJ |
denotes |
Transgenic |
T10637 |
509-519 |
NN |
denotes |
expression |
T10638 |
572-577 |
VBP |
denotes |
cause |
T10639 |
520-522 |
IN |
denotes |
of |
T10640 |
523-529 |
NN |
denotes |
APPswe |
T10641 |
530-533 |
NN |
denotes |
ind |
T10642 |
529-530 |
HYPH |
denotes |
/ |
T10643 |
534-537 |
CC |
denotes |
and |
T10644 |
538-548 |
JJ |
denotes |
consequent |
T10645 |
549-563 |
NN |
denotes |
overproduction |
T10646 |
564-566 |
IN |
denotes |
of |
T10647 |
567-571 |
NN |
denotes |
Aβ42 |
T10648 |
578-583 |
JJ |
denotes |
early |
T10649 |
584-589 |
NN |
denotes |
onset |
T10650 |
583-584 |
HYPH |
denotes |
- |
T10651 |
598-608 |
NN |
denotes |
deposition |
T10652 |
590-597 |
NN |
denotes |
amyloid |
T10653 |
609-611 |
IN |
denotes |
in |
T10654 |
612-621 |
JJ |
denotes |
untreated |
T10655 |
622-626 |
NNS |
denotes |
mice |
T10656 |
626-628 |
, |
denotes |
, |
T10657 |
628-630 |
IN |
denotes |
in |
T10658 |
646-652 |
VBP |
denotes |
appear |
T10659 |
631-636 |
WDT |
denotes |
which |
T10660 |
637-645 |
NNS |
denotes |
deposits |
T10661 |
653-655 |
RB |
denotes |
as |
T10662 |
656-661 |
RB |
denotes |
early |
T10663 |
662-664 |
IN |
denotes |
as |
T10664 |
665-666 |
CD |
denotes |
2 |
T10665 |
667-669 |
NN |
denotes |
mo |
T10666 |
670-672 |
IN |
denotes |
of |
T10667 |
673-676 |
NN |
denotes |
age |
T10668 |
676-677 |
. |
denotes |
. |
T10669 |
677-826 |
sentence |
denotes |
Amyloid burden worsens significantly with age, and by 9 mo, the hippocampus and cortex of untreated mice are largely filled with aggregated peptide. |
T10670 |
678-685 |
NN |
denotes |
Amyloid |
T10671 |
686-692 |
NN |
denotes |
burden |
T10672 |
693-700 |
VBZ |
denotes |
worsens |
T10673 |
701-714 |
RB |
denotes |
significantly |
T10674 |
715-719 |
IN |
denotes |
with |
T10675 |
720-723 |
NN |
denotes |
age |
T10676 |
723-725 |
, |
denotes |
, |
T10677 |
725-728 |
CC |
denotes |
and |
T10678 |
729-731 |
IN |
denotes |
by |
T10679 |
795-801 |
VBN |
denotes |
filled |
T10680 |
732-733 |
CD |
denotes |
9 |
T10681 |
734-736 |
NN |
denotes |
mo |
T10682 |
736-738 |
, |
denotes |
, |
T10683 |
738-741 |
DT |
denotes |
the |
T10684 |
742-753 |
NN |
denotes |
hippocampus |
T10685 |
754-757 |
CC |
denotes |
and |
T10686 |
758-764 |
NN |
denotes |
cortex |
T10687 |
765-767 |
IN |
denotes |
of |
T10688 |
768-777 |
JJ |
denotes |
untreated |
T10689 |
778-782 |
NNS |
denotes |
mice |
T10690 |
783-786 |
VBP |
denotes |
are |
T10691 |
787-794 |
RB |
denotes |
largely |
T10692 |
802-806 |
IN |
denotes |
with |
T10693 |
807-817 |
VBN |
denotes |
aggregated |
T10694 |
818-825 |
NN |
denotes |
peptide |
T10695 |
825-826 |
. |
denotes |
. |
T10696 |
826-939 |
sentence |
denotes |
We find that suppression of transgenic APP by more than 95% abruptly halts the progression of amyloid pathology. |
T10697 |
827-829 |
PRP |
denotes |
We |
T10698 |
830-834 |
VBP |
denotes |
find |
T10699 |
835-839 |
IN |
denotes |
that |
T10700 |
896-901 |
VBZ |
denotes |
halts |
T10701 |
840-851 |
NN |
denotes |
suppression |
T10702 |
852-854 |
IN |
denotes |
of |
T10703 |
855-865 |
JJ |
denotes |
transgenic |
T10704 |
866-869 |
NN |
denotes |
APP |
T10705 |
870-872 |
IN |
denotes |
by |
T10706 |
873-877 |
JJR |
denotes |
more |
T10707 |
883-885 |
CD |
denotes |
95 |
T10708 |
878-882 |
IN |
denotes |
than |
T10709 |
885-886 |
NN |
denotes |
% |
T10710 |
887-895 |
RB |
denotes |
abruptly |
T10711 |
902-905 |
DT |
denotes |
the |
T10712 |
906-917 |
NN |
denotes |
progression |
T10713 |
918-920 |
IN |
denotes |
of |
T10714 |
921-928 |
NN |
denotes |
amyloid |
T10715 |
929-938 |
NN |
denotes |
pathology |
T10716 |
938-939 |
. |
denotes |
. |
T10717 |
939-1132 |
sentence |
denotes |
Importantly, this outcome occurs in animals already harboring considerable amyloid pathology, a situation similar to what might be expected in patients to be treated with secretase inhibitors. |
T10718 |
940-951 |
RB |
denotes |
Importantly |
T10719 |
966-972 |
VBZ |
denotes |
occurs |
T10720 |
951-953 |
, |
denotes |
, |
T10721 |
953-957 |
DT |
denotes |
this |
T10722 |
958-965 |
NN |
denotes |
outcome |
T10723 |
973-975 |
IN |
denotes |
in |
T10724 |
976-983 |
NNS |
denotes |
animals |
T10725 |
984-991 |
RB |
denotes |
already |
T10726 |
992-1001 |
VBG |
denotes |
harboring |
T10727 |
1002-1014 |
JJ |
denotes |
considerable |
T10728 |
1023-1032 |
NN |
denotes |
pathology |
T10729 |
1015-1022 |
NN |
denotes |
amyloid |
T10730 |
1032-1034 |
, |
denotes |
, |
T10731 |
1034-1035 |
DT |
denotes |
a |
T10732 |
1036-1045 |
NN |
denotes |
situation |
T10733 |
1046-1053 |
JJ |
denotes |
similar |
T10734 |
1054-1056 |
IN |
denotes |
to |
T10735 |
1057-1061 |
WP |
denotes |
what |
T10736 |
1071-1079 |
VBN |
denotes |
expected |
T10737 |
1062-1067 |
MD |
denotes |
might |
T10738 |
1068-1070 |
VB |
denotes |
be |
T10739 |
1080-1082 |
IN |
denotes |
in |
T10740 |
1083-1091 |
NNS |
denotes |
patients |
T10741 |
1092-1094 |
TO |
denotes |
to |
T10742 |
1098-1105 |
VBN |
denotes |
treated |
T10743 |
1095-1097 |
VB |
denotes |
be |
T10744 |
1106-1110 |
IN |
denotes |
with |
T10745 |
1111-1120 |
NN |
denotes |
secretase |
T10746 |
1121-1131 |
NNS |
denotes |
inhibitors |
T10747 |
1131-1132 |
. |
denotes |
. |
T10748 |
1132-1305 |
sentence |
denotes |
Somewhat unexpectedly, we observe no appreciable clearance of deposited amyloid even following periods of transgene suppression equal to the time taken for plaques to form. |
T10749 |
1133-1141 |
RB |
denotes |
Somewhat |
T10750 |
1142-1154 |
RB |
denotes |
unexpectedly |
T10751 |
1159-1166 |
VBP |
denotes |
observe |
T10752 |
1154-1156 |
, |
denotes |
, |
T10753 |
1156-1158 |
PRP |
denotes |
we |
T10754 |
1167-1169 |
DT |
denotes |
no |
T10755 |
1182-1191 |
NN |
denotes |
clearance |
T10756 |
1170-1181 |
JJ |
denotes |
appreciable |
T10757 |
1192-1194 |
IN |
denotes |
of |
T10758 |
1195-1204 |
VBN |
denotes |
deposited |
T10759 |
1205-1212 |
NN |
denotes |
amyloid |
T10760 |
1213-1217 |
RB |
denotes |
even |
T10761 |
1218-1227 |
VBG |
denotes |
following |
T10762 |
1228-1235 |
NNS |
denotes |
periods |
T10763 |
1236-1238 |
IN |
denotes |
of |
T10764 |
1239-1248 |
NN |
denotes |
transgene |
T10765 |
1249-1260 |
NN |
denotes |
suppression |
T10766 |
1261-1266 |
JJ |
denotes |
equal |
T10767 |
1267-1269 |
IN |
denotes |
to |
T10768 |
1270-1273 |
DT |
denotes |
the |
T10769 |
1274-1278 |
NN |
denotes |
time |
T10770 |
1279-1284 |
VBN |
denotes |
taken |
T10771 |
1285-1288 |
IN |
denotes |
for |
T10772 |
1300-1304 |
VB |
denotes |
form |
T10773 |
1289-1296 |
NNS |
denotes |
plaques |
T10774 |
1297-1299 |
TO |
denotes |
to |
T10775 |
1304-1305 |
. |
denotes |
. |
T10776 |
1305-1523 |
sentence |
denotes |
This latter finding indicates that compared to other disease-associated protein aggregates such as mutant huntingtin, which clear in less than 3 mo [32], the disaggregation of extracellular amyloid is relatively slow. |
T10777 |
1306-1310 |
DT |
denotes |
This |
T10778 |
1318-1325 |
NN |
denotes |
finding |
T10779 |
1311-1317 |
JJ |
denotes |
latter |
T10780 |
1326-1335 |
VBZ |
denotes |
indicates |
T10781 |
1336-1340 |
IN |
denotes |
that |
T10782 |
1504-1506 |
VBZ |
denotes |
is |
T10783 |
1341-1349 |
VBN |
denotes |
compared |
T10784 |
1350-1352 |
IN |
denotes |
to |
T10785 |
1353-1358 |
JJ |
denotes |
other |
T10786 |
1386-1396 |
NNS |
denotes |
aggregates |
T10787 |
1359-1366 |
NN |
denotes |
disease |
T10788 |
1367-1377 |
VBN |
denotes |
associated |
T10789 |
1366-1367 |
HYPH |
denotes |
- |
T10790 |
1378-1385 |
NN |
denotes |
protein |
T10791 |
1397-1401 |
JJ |
denotes |
such |
T10792 |
1402-1404 |
IN |
denotes |
as |
T10793 |
1405-1411 |
NN |
denotes |
mutant |
T10794 |
1412-1422 |
NN |
denotes |
huntingtin |
T10795 |
1422-1424 |
, |
denotes |
, |
T10796 |
1424-1429 |
WDT |
denotes |
which |
T10797 |
1430-1435 |
VBP |
denotes |
clear |
T10798 |
1436-1438 |
IN |
denotes |
in |
T10799 |
1439-1443 |
JJR |
denotes |
less |
T10800 |
1449-1450 |
CD |
denotes |
3 |
T10801 |
1444-1448 |
IN |
denotes |
than |
T10802 |
1451-1453 |
NN |
denotes |
mo |
T10803 |
1454-1455 |
-LRB- |
denotes |
[ |
T10804 |
1455-1457 |
CD |
denotes |
32 |
T10805 |
1457-1458 |
-RRB- |
denotes |
] |
T10806 |
1458-1460 |
, |
denotes |
, |
T10807 |
1460-1463 |
DT |
denotes |
the |
T10808 |
1464-1478 |
NN |
denotes |
disaggregation |
T10809 |
1479-1481 |
IN |
denotes |
of |
T10810 |
1482-1495 |
JJ |
denotes |
extracellular |
T10811 |
1496-1503 |
NN |
denotes |
amyloid |
T10812 |
1507-1517 |
RB |
denotes |
relatively |
T10813 |
1518-1522 |
JJ |
denotes |
slow |
T10814 |
1522-1523 |
. |
denotes |
. |
R6986 |
T10541 |
T10542 |
nsubj |
We,present |
R6987 |
T10543 |
T10544 |
det |
a,model |
R6988 |
T10544 |
T10542 |
dobj |
model,present |
R6989 |
T10545 |
T10544 |
amod |
new,model |
R6990 |
T10546 |
T10544 |
compound |
mouse,model |
R6991 |
T10547 |
T10544 |
prep |
for,model |
R6992 |
T10548 |
T10547 |
pobj |
AD,for |
R6993 |
T10549 |
T10550 |
dep |
that,designed |
R6994 |
T10550 |
T10544 |
relcl |
designed,model |
R6995 |
T10551 |
T10550 |
auxpass |
was,designed |
R6996 |
T10552 |
T10553 |
aux |
to,test |
R6997 |
T10553 |
T10550 |
advcl |
test,designed |
R6998 |
T10554 |
T10555 |
det |
the,consequences |
R6999 |
T10555 |
T10553 |
dobj |
consequences,test |
R7000 |
T10556 |
T10555 |
prep |
of,consequences |
R7001 |
T10557 |
T10556 |
pcomp |
inhibiting,of |
R7002 |
T10558 |
T10559 |
compound |
Aβ,production |
R7003 |
T10559 |
T10557 |
dobj |
production,inhibiting |
R7004 |
T10560 |
T10557 |
prep |
after,inhibiting |
R7005 |
T10561 |
T10562 |
det |
the,onset |
R7006 |
T10562 |
T10560 |
pobj |
onset,after |
R7007 |
T10563 |
T10562 |
prep |
of,onset |
R7008 |
T10564 |
T10565 |
compound |
amyloid,pathology |
R7009 |
T10565 |
T10563 |
pobj |
pathology,of |
R7010 |
T10566 |
T10542 |
punct |
.,present |
R7011 |
T10568 |
T10569 |
amod |
New,lines |
R7012 |
T10569 |
T10570 |
nsubjpass |
lines,developed |
R7013 |
T10571 |
T10569 |
prep |
of,lines |
R7014 |
T10572 |
T10573 |
amod |
transgenic,mice |
R7015 |
T10573 |
T10571 |
pobj |
mice,of |
R7016 |
T10574 |
T10570 |
auxpass |
were,developed |
R7017 |
T10575 |
T10570 |
prep |
for,developed |
R7018 |
T10576 |
T10577 |
det |
this,study |
R7019 |
T10577 |
T10575 |
pobj |
study,for |
R7020 |
T10578 |
T10579 |
dep |
that,express |
R7021 |
T10579 |
T10570 |
ccomp |
express,developed |
R7022 |
T10580 |
T10581 |
amod |
high,levels |
R7023 |
T10581 |
T10579 |
dobj |
levels,express |
R7024 |
T10582 |
T10581 |
prep |
of,levels |
R7025 |
T10583 |
T10584 |
compound |
APPswe,ind |
R7026 |
T10584 |
T10582 |
pobj |
ind,of |
R7027 |
T10585 |
T10584 |
punct |
/,ind |
R7028 |
T10586 |
T10579 |
prep |
under,express |
R7029 |
T10587 |
T10588 |
det |
the,control |
R7030 |
T10588 |
T10586 |
pobj |
control,under |
R7031 |
T10589 |
T10588 |
prep |
of,control |
R7032 |
T10590 |
T10591 |
det |
a,promoter |
R7033 |
T10591 |
T10589 |
pobj |
promoter,of |
R7034 |
T10592 |
T10593 |
npadvmod |
tetracycline,responsive |
R7035 |
T10593 |
T10591 |
amod |
responsive,promoter |
R7036 |
T10594 |
T10593 |
punct |
-,responsive |
R7037 |
T10595 |
T10570 |
punct |
.,developed |
R7038 |
T10597 |
T10598 |
nsubj |
We,demonstrate |
R7039 |
T10599 |
T10600 |
mark |
that,suppresses |
R7040 |
T10600 |
T10598 |
ccomp |
suppresses,demonstrate |
R7041 |
T10601 |
T10600 |
nsubj |
treatment,suppresses |
R7042 |
T10602 |
T10601 |
prep |
with,treatment |
R7043 |
T10603 |
T10602 |
pobj |
dox,with |
R7044 |
T10604 |
T10605 |
amod |
steady,state |
R7045 |
T10605 |
T10607 |
compound |
state,levels |
R7046 |
T10606 |
T10605 |
punct |
-,state |
R7047 |
T10607 |
T10600 |
dobj |
levels,suppresses |
R7048 |
T10608 |
T10607 |
prep |
of,levels |
R7049 |
T10609 |
T10610 |
preconj |
both,ind |
R7050 |
T10610 |
T10608 |
pobj |
ind,of |
R7051 |
T10611 |
T10610 |
compound |
APPswe,ind |
R7052 |
T10612 |
T10610 |
punct |
/,ind |
R7053 |
T10613 |
T10610 |
cc |
and,ind |
R7054 |
T10614 |
T10615 |
poss |
its,fragments |
R7055 |
T10615 |
T10610 |
conj |
fragments,ind |
R7056 |
T10616 |
T10615 |
nmod |
C,fragments |
R7057 |
T10617 |
T10615 |
punct |
-,fragments |
R7058 |
T10618 |
T10615 |
amod |
terminal,fragments |
R7059 |
T10619 |
T10600 |
punct |
", ",suppresses |
R7060 |
T10620 |
T10600 |
advcl |
indicating,suppresses |
R7061 |
T10621 |
T10622 |
mark |
that,have |
R7062 |
T10622 |
T10620 |
ccomp |
have,indicating |
R7063 |
T10623 |
T10624 |
det |
the,proteins |
R7064 |
T10624 |
T10622 |
nsubj |
proteins,have |
R7065 |
T10625 |
T10624 |
compound |
mutant,proteins |
R7066 |
T10626 |
T10627 |
det |
a,life |
R7067 |
T10627 |
T10622 |
dobj |
life,have |
R7068 |
T10628 |
T10629 |
advmod |
relatively,short |
R7069 |
T10629 |
T10627 |
amod |
short,life |
R7070 |
T10630 |
T10627 |
compound |
half,life |
R7071 |
T10631 |
T10627 |
punct |
-,life |
R7072 |
T10632 |
T10633 |
advmod |
in,vivo |
R7073 |
T10633 |
T10622 |
advmod |
vivo,have |
R7074 |
T10634 |
T10598 |
punct |
.,demonstrate |
R7075 |
T10636 |
T10637 |
amod |
Transgenic,expression |
R7076 |
T10637 |
T10638 |
nsubj |
expression,cause |
R7077 |
T10639 |
T10637 |
prep |
of,expression |
R7078 |
T10640 |
T10641 |
compound |
APPswe,ind |
R7079 |
T10641 |
T10639 |
pobj |
ind,of |
R7080 |
T10642 |
T10641 |
punct |
/,ind |
R7081 |
T10643 |
T10637 |
cc |
and,expression |
R7082 |
T10644 |
T10645 |
amod |
consequent,overproduction |
R7083 |
T10645 |
T10637 |
conj |
overproduction,expression |
R7084 |
T10646 |
T10645 |
prep |
of,overproduction |
R7085 |
T10647 |
T10646 |
pobj |
Aβ42,of |
R7086 |
T10648 |
T10649 |
amod |
early,onset |
R7087 |
T10649 |
T10651 |
compound |
onset,deposition |
R7088 |
T10650 |
T10649 |
punct |
-,onset |
R7089 |
T10651 |
T10638 |
dobj |
deposition,cause |
R7090 |
T10652 |
T10651 |
compound |
amyloid,deposition |
R7091 |
T10653 |
T10638 |
prep |
in,cause |
R7092 |
T10654 |
T10655 |
amod |
untreated,mice |
R7093 |
T10655 |
T10653 |
pobj |
mice,in |
R7094 |
T10656 |
T10655 |
punct |
", ",mice |
R7095 |
T10657 |
T10658 |
prep |
in,appear |
R7096 |
T10658 |
T10655 |
relcl |
appear,mice |
R7097 |
T10659 |
T10657 |
pobj |
which,in |
R7098 |
T10660 |
T10658 |
nsubj |
deposits,appear |
R7099 |
T10661 |
T10662 |
advmod |
as,early |
R7100 |
T10662 |
T10658 |
advmod |
early,appear |
R7101 |
T10663 |
T10662 |
prep |
as,early |
R7102 |
T10664 |
T10665 |
nummod |
2,mo |
R7103 |
T10665 |
T10663 |
pobj |
mo,as |
R7104 |
T10666 |
T10665 |
prep |
of,mo |
R7105 |
T10667 |
T10666 |
pobj |
age,of |
R7106 |
T10668 |
T10638 |
punct |
.,cause |
R7107 |
T10670 |
T10671 |
compound |
Amyloid,burden |
R7108 |
T10671 |
T10672 |
nsubj |
burden,worsens |
R7109 |
T10673 |
T10672 |
advmod |
significantly,worsens |
R7110 |
T10674 |
T10672 |
prep |
with,worsens |
R7111 |
T10675 |
T10674 |
pobj |
age,with |
R7112 |
T10676 |
T10672 |
punct |
", ",worsens |
R7113 |
T10677 |
T10672 |
cc |
and,worsens |
R7114 |
T10678 |
T10679 |
prep |
by,filled |
R7115 |
T10679 |
T10672 |
conj |
filled,worsens |
R7116 |
T10680 |
T10681 |
nummod |
9,mo |
R7117 |
T10681 |
T10678 |
pobj |
mo,by |
R7118 |
T10682 |
T10679 |
punct |
", ",filled |
R7119 |
T10683 |
T10684 |
det |
the,hippocampus |
R7120 |
T10684 |
T10679 |
nsubjpass |
hippocampus,filled |
R7121 |
T10685 |
T10684 |
cc |
and,hippocampus |
R7122 |
T10686 |
T10684 |
conj |
cortex,hippocampus |
R7123 |
T10687 |
T10684 |
prep |
of,hippocampus |
R7124 |
T10688 |
T10689 |
amod |
untreated,mice |
R7125 |
T10689 |
T10687 |
pobj |
mice,of |
R7126 |
T10690 |
T10679 |
auxpass |
are,filled |
R7127 |
T10691 |
T10679 |
advmod |
largely,filled |
R7128 |
T10692 |
T10679 |
prep |
with,filled |
R7129 |
T10693 |
T10694 |
amod |
aggregated,peptide |
R7130 |
T10694 |
T10692 |
pobj |
peptide,with |
R7131 |
T10695 |
T10679 |
punct |
.,filled |
R7132 |
T10697 |
T10698 |
nsubj |
We,find |
R7133 |
T10699 |
T10700 |
mark |
that,halts |
R7134 |
T10700 |
T10698 |
ccomp |
halts,find |
R7135 |
T10701 |
T10700 |
nsubj |
suppression,halts |
R7136 |
T10702 |
T10701 |
prep |
of,suppression |
R7137 |
T10703 |
T10704 |
amod |
transgenic,APP |
R7138 |
T10704 |
T10702 |
pobj |
APP,of |
R7139 |
T10705 |
T10701 |
prep |
by,suppression |
R7140 |
T10706 |
T10707 |
amod |
more,95 |
R7141 |
T10707 |
T10709 |
nummod |
95,% |
R7142 |
T10708 |
T10707 |
quantmod |
than,95 |
R7143 |
T10709 |
T10705 |
pobj |
%,by |
R7144 |
T10710 |
T10700 |
advmod |
abruptly,halts |
R7145 |
T10711 |
T10712 |
det |
the,progression |
R7146 |
T10712 |
T10700 |
dobj |
progression,halts |
R7147 |
T10713 |
T10712 |
prep |
of,progression |
R7148 |
T10714 |
T10715 |
compound |
amyloid,pathology |
R7149 |
T10715 |
T10713 |
pobj |
pathology,of |
R7150 |
T10716 |
T10698 |
punct |
.,find |
R7151 |
T10718 |
T10719 |
advmod |
Importantly,occurs |
R7152 |
T10720 |
T10719 |
punct |
", ",occurs |
R7153 |
T10721 |
T10722 |
det |
this,outcome |
R7154 |
T10722 |
T10719 |
nsubj |
outcome,occurs |
R7155 |
T10723 |
T10719 |
prep |
in,occurs |
R7156 |
T10724 |
T10723 |
pobj |
animals,in |
R7157 |
T10725 |
T10726 |
advmod |
already,harboring |
R7158 |
T10726 |
T10724 |
acl |
harboring,animals |
R7159 |
T10727 |
T10728 |
amod |
considerable,pathology |
R7160 |
T10728 |
T10726 |
dobj |
pathology,harboring |
R7161 |
T10729 |
T10728 |
compound |
amyloid,pathology |
R7162 |
T10730 |
T10719 |
punct |
", ",occurs |
R7163 |
T10731 |
T10732 |
det |
a,situation |
R7164 |
T10732 |
T10719 |
npadvmod |
situation,occurs |
R7165 |
T10733 |
T10732 |
amod |
similar,situation |
R7166 |
T10734 |
T10733 |
prep |
to,similar |
R7167 |
T10735 |
T10736 |
dep |
what,expected |
R7168 |
T10736 |
T10734 |
pcomp |
expected,to |
R7169 |
T10737 |
T10736 |
aux |
might,expected |
R7170 |
T10738 |
T10736 |
auxpass |
be,expected |
R7171 |
T10739 |
T10736 |
prep |
in,expected |
R7172 |
T10740 |
T10739 |
pobj |
patients,in |
R7173 |
T10741 |
T10742 |
aux |
to,treated |
R7174 |
T10742 |
T10740 |
advcl |
treated,patients |
R7175 |
T10743 |
T10742 |
auxpass |
be,treated |
R7176 |
T10744 |
T10742 |
prep |
with,treated |
R7177 |
T10745 |
T10746 |
compound |
secretase,inhibitors |
R7178 |
T10746 |
T10744 |
pobj |
inhibitors,with |
R7179 |
T10747 |
T10719 |
punct |
.,occurs |
R7180 |
T10749 |
T10750 |
advmod |
Somewhat,unexpectedly |
R7181 |
T10750 |
T10751 |
advmod |
unexpectedly,observe |
R7182 |
T10752 |
T10751 |
punct |
", ",observe |
R7183 |
T10753 |
T10751 |
nsubj |
we,observe |
R7184 |
T10754 |
T10755 |
det |
no,clearance |
R7185 |
T10755 |
T10751 |
dobj |
clearance,observe |
R7186 |
T10756 |
T10755 |
amod |
appreciable,clearance |
R7187 |
T10757 |
T10755 |
prep |
of,clearance |
R7188 |
T10758 |
T10759 |
amod |
deposited,amyloid |
R7189 |
T10759 |
T10757 |
pobj |
amyloid,of |
R7190 |
T10760 |
T10761 |
advmod |
even,following |
R7191 |
T10761 |
T10751 |
prep |
following,observe |
R7192 |
T10762 |
T10761 |
pobj |
periods,following |
R7193 |
T10763 |
T10762 |
prep |
of,periods |
R7194 |
T10764 |
T10765 |
compound |
transgene,suppression |
R7195 |
T10765 |
T10763 |
pobj |
suppression,of |
R7196 |
T10766 |
T10762 |
amod |
equal,periods |
R7197 |
T10767 |
T10766 |
prep |
to,equal |
R7198 |
T10768 |
T10769 |
det |
the,time |
R7199 |
T10769 |
T10767 |
pobj |
time,to |
R7200 |
T10770 |
T10769 |
advcl |
taken,time |
R7201 |
T10771 |
T10772 |
mark |
for,form |
R7202 |
T10772 |
T10770 |
advcl |
form,taken |
R7203 |
T10773 |
T10772 |
nsubj |
plaques,form |
R7204 |
T10774 |
T10772 |
aux |
to,form |
R7205 |
T10775 |
T10751 |
punct |
.,observe |
R7206 |
T10777 |
T10778 |
det |
This,finding |
R7207 |
T10778 |
T10780 |
nsubj |
finding,indicates |
R7208 |
T10779 |
T10778 |
amod |
latter,finding |
R7209 |
T10781 |
T10782 |
mark |
that,is |
R7210 |
T10782 |
T10780 |
ccomp |
is,indicates |
R7211 |
T10783 |
T10782 |
prep |
compared,is |
R7212 |
T10784 |
T10783 |
prep |
to,compared |
R7213 |
T10785 |
T10786 |
amod |
other,aggregates |
R7214 |
T10786 |
T10784 |
pobj |
aggregates,to |
R7215 |
T10787 |
T10788 |
npadvmod |
disease,associated |
R7216 |
T10788 |
T10786 |
amod |
associated,aggregates |
R7217 |
T10789 |
T10788 |
punct |
-,associated |
R7218 |
T10790 |
T10786 |
compound |
protein,aggregates |
R7219 |
T10791 |
T10792 |
amod |
such,as |
R7220 |
T10792 |
T10786 |
prep |
as,aggregates |
R7221 |
T10793 |
T10794 |
compound |
mutant,huntingtin |
R7222 |
T10794 |
T10792 |
pobj |
huntingtin,as |
R7223 |
T10795 |
T10794 |
punct |
", ",huntingtin |
R7224 |
T10796 |
T10797 |
dep |
which,clear |
R7225 |
T10797 |
T10794 |
relcl |
clear,huntingtin |
R7226 |
T10798 |
T10797 |
prep |
in,clear |
R7227 |
T10799 |
T10800 |
amod |
less,3 |
R7228 |
T10800 |
T10802 |
nummod |
3,mo |
R7229 |
T10801 |
T10800 |
quantmod |
than,3 |
R7230 |
T10802 |
T10798 |
pobj |
mo,in |
R7231 |
T10803 |
T10804 |
punct |
[,32 |
R7232 |
T10804 |
T10797 |
parataxis |
32,clear |
R7233 |
T10805 |
T10804 |
punct |
],32 |
R7234 |
T10806 |
T10782 |
punct |
", ",is |
R7235 |
T10807 |
T10808 |
det |
the,disaggregation |
R7236 |
T10808 |
T10782 |
nsubj |
disaggregation,is |
R7237 |
T10809 |
T10808 |
prep |
of,disaggregation |
R7238 |
T10810 |
T10811 |
amod |
extracellular,amyloid |
R7239 |
T10811 |
T10809 |
pobj |
amyloid,of |
R7240 |
T10812 |
T10813 |
advmod |
relatively,slow |
R7241 |
T10813 |
T10782 |
acomp |
slow,is |
R7242 |
T10814 |
T10780 |
punct |
.,indicates |