PMC:1283364 / 4723-4979 JSONTXT

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    craft-sa-dev

    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in patients. However, the chemical secretase inhibitors most likely to reach human trials are still in development. Therefore, we developed a mouse model of Alzheimer-type amyloid that expresses a controllable APP transgene. This system, commonly known as"}

    craft-ca-core-ex-dev

    {"project":"craft-ca-core-ex-dev","denotations":[{"id":"T684","span":{"begin":27,"end":35},"obj":"CHEBI_EXT:chemical_substance_or_polyatomic_entity"},{"id":"T685","span":{"begin":46,"end":56},"obj":"CHEBI_EXT:35222"},{"id":"T686","span":{"begin":78,"end":83},"obj":"NCBITaxon:9606"},{"id":"T687","span":{"begin":143,"end":148},"obj":"NCBITaxon:10088"},{"id":"T688","span":{"begin":173,"end":180},"obj":"CHEBI:60425"},{"id":"T689","span":{"begin":186,"end":195},"obj":"GO:0010467"},{"id":"T690","span":{"begin":198,"end":210},"obj":"GO:0065007"},{"id":"T691","span":{"begin":211,"end":214},"obj":"PR_EXT:000004168"},{"id":"T692","span":{"begin":215,"end":224},"obj":"SO_EXT:0000902"}],"text":" in patients. However, the chemical secretase inhibitors most likely to reach human trials are still in development. Therefore, we developed a mouse model of Alzheimer-type amyloid that expresses a controllable APP transgene. This system, commonly known as"}

    craft-ca-core-dev

    {"project":"craft-ca-core-dev","denotations":[{"id":"T591","span":{"begin":46,"end":56},"obj":"CHEBI:35222"},{"id":"T592","span":{"begin":78,"end":83},"obj":"NCBITaxon:9606"},{"id":"T593","span":{"begin":143,"end":148},"obj":"NCBITaxon:10088"},{"id":"T594","span":{"begin":173,"end":180},"obj":"CHEBI:60425"},{"id":"T595","span":{"begin":186,"end":195},"obj":"GO:0010467"},{"id":"T596","span":{"begin":198,"end":210},"obj":"GO:0065007"},{"id":"T597","span":{"begin":211,"end":214},"obj":"PR:000004168"},{"id":"T598","span":{"begin":215,"end":224},"obj":"SO:0000902"}],"text":" in patients. However, the chemical secretase inhibitors most likely to reach human trials are still in development. Therefore, we developed a mouse model of Alzheimer-type amyloid that expresses a controllable APP transgene. This system, commonly known as"}