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PMC:1283364 / 38209-39095 JSONTXT

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Id Subject Object Predicate Lexical cue
T8414 0-2 TO denotes To
T8415 3-10 VB denotes confirm
T8416 108-116 VBD denotes repeated
T8417 11-15 IN denotes that
T8418 68-71 VBD denotes was
T8419 16-19 DT denotes the
T8420 20-26 NN denotes arrest
T8421 27-29 IN denotes of
T8422 30-37 NNS denotes plaques
T8423 38-45 IN denotes without
T8424 46-49 DT denotes any
T8425 50-54 NN denotes sign
T8426 55-57 IN denotes of
T8427 58-67 NN denotes clearance
T8428 72-75 RB denotes not
T8429 76-82 JJ denotes unique
T8430 83-85 IN denotes to
T8431 86-89 DT denotes the
T8432 99-103 NNS denotes mice
T8433 90-94 NN denotes line
T8434 95-98 CD denotes 107
T8435 103-105 , denotes ,
T8436 105-107 PRP denotes we
T8437 117-120 DT denotes the
T8438 137-147 NN denotes experiment
T8439 121-124 NN denotes dox
T8440 125-136 NN denotes suppression
T8441 124-125 HYPH denotes -
T8442 148-150 IN denotes in
T8443 151-152 DT denotes a
T8444 160-164 NN denotes line
T8445 153-159 JJ denotes second
T8446 165-167 IN denotes of
T8447 168-171 NN denotes tet
T8448 172-175 NN denotes off
T8449 171-172 HYPH denotes -
T8450 180-184 NNS denotes mice
T8451 176-179 NN denotes APP
T8452 185-186 -LRB- denotes (
T8453 215-219 NN denotes line
T8454 186-193 NN denotes CaMKIIα
T8455 211-214 NN denotes ind
T8456 193-194 HYPH denotes -
T8457 194-197 NN denotes tTA
T8458 198-199 SYM denotes ×
T8459 200-203 NN denotes tet
T8460 203-204 HYPH denotes -
T8461 204-210 NN denotes APPswe
T8462 210-211 HYPH denotes /
T8463 220-222 CD denotes 18
T8464 222-223 : denotes ;
T8465 224-225 NN denotes n
T8466 228-230 CD denotes 22
T8467 226-227 SYM denotes =
T8468 230-231 -RRB- denotes )
T8469 231-232 . denotes .
T8470 232-425 sentence denotes Again, long-term dox treatment was begun at 6 mo of age, and mice were harvested after 3 mo of transgene suppression (6 mo untreated, n = 8; 9 mo untreated, n = 6; 6 mo + 3 mo treated, n = 8).
T8471 233-238 RB denotes Again
T8472 268-273 VBN denotes begun
T8473 238-240 , denotes ,
T8474 240-244 JJ denotes long
T8475 245-249 NN denotes term
T8476 244-245 HYPH denotes -
T8477 254-263 NN denotes treatment
T8478 250-253 NN denotes dox
T8479 264-267 VBD denotes was
T8480 274-276 IN denotes at
T8481 277-278 CD denotes 6
T8482 279-281 NN denotes mo
T8483 282-284 IN denotes of
T8484 285-288 NN denotes age
T8485 288-290 , denotes ,
T8486 290-293 CC denotes and
T8487 294-298 NNS denotes mice
T8488 304-313 VBN denotes harvested
T8489 299-303 VBD denotes were
T8490 314-319 IN denotes after
T8491 320-321 CD denotes 3
T8492 322-324 NN denotes mo
T8493 325-327 IN denotes of
T8494 328-337 NN denotes transgene
T8495 338-349 NN denotes suppression
T8496 350-351 -LRB- denotes (
T8497 422-423 CD denotes 8
T8498 351-352 CD denotes 6
T8499 353-355 NN denotes mo
T8500 356-365 JJ denotes untreated
T8501 371-372 CD denotes 8
T8502 365-367 , denotes ,
T8503 367-368 NN denotes n
T8504 369-370 SYM denotes =
T8505 372-373 : denotes ;
T8506 374-375 CD denotes 9
T8507 376-378 NN denotes mo
T8508 379-388 JJ denotes untreated
T8509 394-395 CD denotes 6
T8510 388-390 , denotes ,
T8511 390-391 NN denotes n
T8512 392-393 SYM denotes =
T8513 395-396 : denotes ;
T8514 397-398 CD denotes 6
T8515 406-408 NN denotes mo
T8516 399-401 NN denotes mo
T8517 402-403 SYM denotes +
T8518 404-405 CD denotes 3
T8519 409-416 VBN denotes treated
T8520 416-418 , denotes ,
T8521 418-419 NN denotes n
T8522 420-421 SYM denotes =
T8523 423-424 -RRB- denotes )
T8524 424-425 . denotes .
T8525 425-521 sentence denotes Immunoblotting for APP confirmed full transgene suppression in the treated animals (Figure S5).
T8526 426-440 NN denotes Immunoblotting
T8527 449-458 VBD denotes confirmed
T8528 441-444 IN denotes for
T8529 445-448 NN denotes APP
T8530 459-463 JJ denotes full
T8531 474-485 NN denotes suppression
T8532 464-473 NN denotes transgene
T8533 486-488 IN denotes in
T8534 489-492 DT denotes the
T8535 501-508 NNS denotes animals
T8536 493-500 VBN denotes treated
T8537 509-510 -LRB- denotes (
T8538 517-519 NN denotes S5
T8539 510-516 NN denotes Figure
T8540 519-520 -RRB- denotes )
T8541 520-521 . denotes .
T8542 521-649 sentence denotes As in the line 107 mice described above, amyloid burden worsened substantially in the untreated mice between 6 and 9 mo of age.
T8543 522-524 IN denotes As
T8544 578-586 VBD denotes worsened
T8545 525-527 IN denotes in
T8546 528-531 DT denotes the
T8547 541-545 NNS denotes mice
T8548 532-536 NN denotes line
T8549 537-540 CD denotes 107
T8550 546-555 VBN denotes described
T8551 556-561 RB denotes above
T8552 561-563 , denotes ,
T8553 563-570 NN denotes amyloid
T8554 571-577 NN denotes burden
T8555 587-600 RB denotes substantially
T8556 601-603 IN denotes in
T8557 604-607 DT denotes the
T8558 618-622 NNS denotes mice
T8559 608-617 JJ denotes untreated
T8560 623-630 IN denotes between
T8561 631-632 CD denotes 6
T8562 639-641 NN denotes mo
T8563 633-636 CC denotes and
T8564 637-638 CD denotes 9
T8565 642-644 IN denotes of
T8566 645-648 NN denotes age
T8567 648-649 . denotes .
T8568 649-782 sentence denotes Suppression of transgene expression abruptly arrested progression of pathology (Figure S6), but again without any sign of reduction.
T8569 650-661 NN denotes Suppression
T8570 695-703 VBD denotes arrested
T8571 662-664 IN denotes of
T8572 665-674 NN denotes transgene
T8573 675-685 NN denotes expression
T8574 686-694 RB denotes abruptly
T8575 704-715 NN denotes progression
T8576 716-718 IN denotes of
T8577 719-728 NN denotes pathology
T8578 729-730 -LRB- denotes (
T8579 737-739 NN denotes S6
T8580 730-736 NN denotes Figure
T8581 739-740 -RRB- denotes )
T8582 740-742 , denotes ,
T8583 742-745 CC denotes but
T8584 752-759 IN denotes without
T8585 746-751 RB denotes again
T8586 760-763 DT denotes any
T8587 764-768 NN denotes sign
T8588 769-771 IN denotes of
T8589 772-781 NN denotes reduction
T8590 781-782 . denotes .
T8591 782-886 sentence denotes Both silver- and thioflavin-S-positive plaques could still be found in each of the dox-treated animals.
T8592 783-787 CC denotes Both
T8593 788-794 NN denotes silver
T8594 813-821 JJ denotes positive
T8595 794-795 HYPH denotes -
T8596 796-799 CC denotes and
T8597 800-810 NN denotes thioflavin
T8598 811-812 NN denotes S
T8599 810-811 HYPH denotes -
T8600 812-813 HYPH denotes -
T8601 822-829 NNS denotes plaques
T8602 845-850 VBN denotes found
T8603 830-835 MD denotes could
T8604 836-841 RB denotes still
T8605 842-844 VB denotes be
T8606 851-853 IN denotes in
T8607 854-858 DT denotes each
T8608 859-861 IN denotes of
T8609 862-865 DT denotes the
T8610 878-885 NNS denotes animals
T8611 866-869 NN denotes dox
T8612 870-877 VBN denotes treated
T8613 869-870 HYPH denotes -
T8614 885-886 . denotes .
R5753 T8414 T8415 aux To,confirm
R5754 T8415 T8416 advcl confirm,repeated
R5756 T8417 T8418 mark that,was
R5757 T8418 T8415 ccomp was,confirm
R5759 T8419 T8420 det the,arrest
R5760 T8420 T8418 nsubj arrest,was
R5761 T8421 T8420 prep of,arrest
R5763 T8422 T8421 pobj plaques,of
R5764 T8423 T8420 prep without,arrest
R5766 T8424 T8425 det any,sign
R5767 T8425 T8423 pobj sign,without
R5768 T8426 T8425 prep of,sign
R5770 T8427 T8426 pobj clearance,of
R5771 T8428 T8418 neg not,was
R5775 T8429 T8418 acomp unique,was
R5776 T8430 T8429 prep to,unique
R5778 T8431 T8432 det the,mice
R5779 T8432 T8430 pobj mice,to
R5781 T8433 T8432 nmod line,mice
R5782 T8434 T8433 nummod 107,line
R5783 T8435 T8416 punct ", ",repeated
R5784 T8436 T8416 nsubj we,repeated
R5785 T8437 T8438 det the,experiment
R5786 T8438 T8416 dobj experiment,repeated
R5788 T8439 T8440 compound dox,suppression
R5789 T8440 T8438 compound suppression,experiment
R5791 T8441 T8440 punct -,suppression
R5792 T8442 T8416 prep in,repeated
R5793 T8443 T8444 det a,line
R5795 T8444 T8442 pobj line,in
R5796 T8445 T8444 amod second,line
R5797 T8446 T8444 prep of,line
R5798 T8496 T8497 punct (,8
R5799 T8447 T8448 compound tet,off
R5800 T8448 T8450 compound off,mice
R5801 T8449 T8448 punct -,off
R5802 T8497 T8488 parataxis 8,harvested
R5803 T8498 T8499 nummod 6,mo
R5804 T8450 T8446 pobj mice,of
R5805 T8451 T8450 compound APP,mice
R5806 T8499 T8500 npadvmod mo,untreated
R5807 T8452 T8453 punct (,line
R5808 T8453 T8416 parataxis line,repeated
R5809 T8500 T8501 amod untreated,8
R5810 T8454 T8455 nmod CaMKIIα,ind
R5811 T8455 T8453 compound ind,line
R5812 T8501 T8497 dep 8,8
R5813 T8456 T8455 punct -,ind
R5814 T8457 T8455 nmod tTA,ind
R5815 T8458 T8455 punct ×,ind
R5816 T8502 T8501 punct ", ",8
R5817 T8459 T8455 compound tet,ind
R5818 T8460 T8455 punct -,ind
R5819 T8503 T8501 nsubj n,8
R5820 T8461 T8455 compound APPswe,ind
R5821 T8462 T8455 punct /,ind
R5822 T8463 T8453 nummod 18,line
R5823 T8504 T8501 punct =,8
R5824 T8464 T8453 punct ;,line
R5825 T8465 T8466 nsubj n,22
R5826 T8505 T8497 punct ;,8
R5827 T8466 T8453 ccomp 22,line
R5828 T8467 T8466 punct =,22
R5829 T8468 T8453 punct ),line
R5830 T8506 T8507 nummod 9,mo
R5831 T8469 T8416 punct .,repeated
R5832 T8471 T8472 advmod Again,begun
R5833 T8473 T8472 punct ", ",begun
R5834 T8507 T8508 npadvmod mo,untreated
R5835 T8474 T8475 amod long,term
R5836 T8475 T8477 compound term,treatment
R5837 T8476 T8475 punct -,term
R5838 T8508 T8509 amod untreated,6
R5839 T8477 T8472 nsubjpass treatment,begun
R5840 T8478 T8477 compound dox,treatment
R5841 T8509 T8497 dep 6,8
R5842 T8479 T8472 auxpass was,begun
R5843 T8480 T8472 prep at,begun
R5844 T8481 T8482 nummod 6,mo
R5845 T8510 T8509 punct ", ",6
R5846 T8482 T8480 pobj mo,at
R5847 T8483 T8482 prep of,mo
R5848 T8511 T8509 nsubj n,6
R5849 T8484 T8483 pobj age,of
R5850 T8485 T8472 punct ", ",begun
R5851 T8486 T8472 cc and,begun
R5852 T8512 T8509 punct =,6
R5853 T8487 T8488 nsubjpass mice,harvested
R5854 T8488 T8472 conj harvested,begun
R5855 T8489 T8488 auxpass were,harvested
R5856 T8513 T8497 punct ;,8
R5857 T8490 T8488 prep after,harvested
R5858 T8491 T8492 nummod 3,mo
R5859 T8514 T8515 nummod 6,mo
R5860 T8492 T8490 pobj mo,after
R5861 T8493 T8492 prep of,mo
R5862 T8494 T8495 compound transgene,suppression
R5863 T8515 T8519 npadvmod mo,treated
R5864 T8495 T8493 pobj suppression,of
R5865 T8516 T8515 nmod mo,mo
R5866 T8517 T8515 punct +,mo
R5867 T8518 T8515 nummod 3,mo
R5868 T8519 T8497 amod treated,8
R5869 T8603 T8602 aux could,found
R5870 T8520 T8497 punct ", ",8
R5871 T8604 T8602 advmod still,found
R5872 T8605 T8602 auxpass be,found
R5873 T8606 T8602 prep in,found
R5874 T8521 T8497 nsubj n,8
R5875 T8607 T8606 pobj each,in
R5876 T8608 T8607 prep of,each
R5877 T8522 T8497 punct =,8
R5878 T8609 T8610 det the,animals
R5879 T8610 T8608 pobj animals,of
R5880 T8611 T8612 npadvmod dox,treated
R5881 T8523 T8497 punct ),8
R5882 T8612 T8610 amod treated,animals
R5883 T8613 T8612 punct -,treated
R5884 T8614 T8602 punct .,found
R5886 T8524 T8488 punct .,harvested
R5889 T8526 T8527 nsubj Immunoblotting,confirmed
R5894 T8528 T8526 prep for,Immunoblotting
R5896 T8529 T8528 pobj APP,for
R5897 T8530 T8531 amod full,suppression
R5900 T8531 T8527 dobj suppression,confirmed
R5904 T8532 T8531 compound transgene,suppression
R5907 T8533 T8527 prep in,confirmed
R5910 T8534 T8535 det the,animals
R5914 T8535 T8533 pobj animals,in
R5917 T8536 T8535 amod treated,animals
R5921 T8537 T8538 punct (,S5
R5925 T8538 T8527 parataxis S5,confirmed
R5927 T8539 T8538 compound Figure,S5
R5931 T8540 T8538 punct ),S5
R5934 T8541 T8527 punct .,confirmed
R5940 T8543 T8544 prep As,worsened
R5944 T8545 T8543 prep in,As
R5949 T8546 T8547 det the,mice
R5952 T8547 T8545 pobj mice,in
R5955 T8548 T8547 nmod line,mice
R5958 T8549 T8548 nummod 107,line
R5962 T8550 T8547 acl described,mice
R5965 T8551 T8550 advmod above,described
R5968 T8552 T8544 punct ", ",worsened
R5971 T8553 T8554 compound amyloid,burden
R5975 T8554 T8544 nsubj burden,worsened
R5978 T8555 T8544 advmod substantially,worsened
R5981 T8556 T8544 prep in,worsened
R5983 T8557 T8558 det the,mice
R5986 T8558 T8556 pobj mice,in
R5993 T8559 T8558 amod untreated,mice
R5996 T8560 T8558 prep between,mice
R6000 T8561 T8562 nummod 6,mo
R6003 T8562 T8560 pobj mo,between
R6007 T8563 T8561 cc and,6
R6008 T8564 T8561 conj 9,6
R6009 T8565 T8562 prep of,mo
R6010 T8566 T8565 pobj age,of
R6013 T8567 T8544 punct .,worsened
R6014 T8569 T8570 nsubj Suppression,arrested
R6015 T8571 T8569 prep of,Suppression
R6019 T8572 T8573 compound transgene,expression
R6022 T8573 T8571 pobj expression,of
R6025 T8574 T8570 advmod abruptly,arrested
R6028 T8575 T8570 dobj progression,arrested
R6031 T8576 T8575 prep of,progression
R6035 T8577 T8576 pobj pathology,of
R6038 T8578 T8579 punct (,S6
R6044 T8579 T8570 parataxis S6,arrested
R6048 T8580 T8579 compound Figure,S6
R6051 T8581 T8579 punct ),S6
R6053 T8582 T8570 punct ", ",arrested
R6056 T8583 T8584 cc but,without
R6059 T8584 T8570 prep without,arrested
R6063 T8585 T8584 advmod again,without
R6066 T8586 T8587 det any,sign
R6069 T8587 T8584 pobj sign,without
R6072 T8588 T8587 prep of,sign
R6076 T8589 T8588 pobj reduction,of
R6079 T8590 T8570 punct .,arrested
R6083 T8592 T8593 preconj Both,silver
R6086 T8593 T8594 npadvmod silver,positive
R6090 T8594 T8601 amod positive,plaques
R6095 T8595 T8593 punct -,silver
R6099 T8596 T8593 cc and,silver
R6101 T8597 T8598 compound thioflavin,S
R6104 T8598 T8593 conj S,silver
R6107 T8599 T8598 punct -,S
R6111 T8600 T8594 punct -,positive
R6114 T8601 T8602 nsubjpass plaques,found

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6372 99-103 NCBITaxon:10088 denotes mice
T6373 121-124 CHEBI:50845 denotes dox
T6374 176-179 PR_EXT:000004168 denotes APP
T6375 180-184 NCBITaxon:10088 denotes mice
T6376 186-193 PR_EXT:000003199 denotes CaMKIIα
T6377 250-253 CHEBI:50845 denotes dox
T6378 294-298 NCBITaxon:10088 denotes mice
T6379 328-337 SO_EXT:0000902 denotes transgene
T6380 445-448 PR_EXT:000004168 denotes APP
T6381 464-473 SO_EXT:0000902 denotes transgene
T6382 501-508 NCBITaxon:33208 denotes animals
T6383 541-545 NCBITaxon:10088 denotes mice
T6384 563-570 CHEBI:60425 denotes amyloid
T6385 618-622 NCBITaxon:10088 denotes mice
T6386 665-674 SO_EXT:0000902 denotes transgene
T6387 675-685 GO:0010467 denotes expression
T6388 788-794 CHEBI_EXT:silver denotes silver
T6389 866-869 CHEBI:50845 denotes dox
T6390 878-885 NCBITaxon:33208 denotes animals

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6013 99-103 NCBITaxon:10088 denotes mice
T6014 121-124 CHEBI:50845 denotes dox
T6015 176-179 PR:000004168 denotes APP
T6016 180-184 NCBITaxon:10088 denotes mice
T6017 186-193 PR:000003199 denotes CaMKIIα
T6018 250-253 CHEBI:50845 denotes dox
T6019 294-298 NCBITaxon:10088 denotes mice
T6020 328-337 SO:0000902 denotes transgene
T6021 445-448 PR:000004168 denotes APP
T6022 464-473 SO:0000902 denotes transgene
T6023 501-508 NCBITaxon:33208 denotes animals
T6024 541-545 NCBITaxon:10088 denotes mice
T6025 563-570 CHEBI:60425 denotes amyloid
T6026 618-622 NCBITaxon:10088 denotes mice
T6027 665-674 SO:0000902 denotes transgene
T6028 675-685 GO:0010467 denotes expression
T6029 866-869 CHEBI:50845 denotes dox
T6030 878-885 NCBITaxon:33208 denotes animals