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PMC:1283364 / 25130-27512 JSONTXT

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Id Subject Object Predicate Lexical cue
T6995 0-2 TO denotes To
T6996 3-9 VB denotes ensure
T6997 120-128 VBD denotes measured
T6998 10-14 IN denotes that
T6999 33-43 VBN denotes suppressed
T7000 15-17 NN denotes Aβ
T7001 18-28 NN denotes production
T7002 29-32 VBD denotes was
T7003 44-46 IN denotes in
T7004 47-54 NN denotes concert
T7005 55-59 IN denotes with
T7006 60-63 DT denotes the
T7007 77-87 NN denotes inhibition
T7008 64-67 NN denotes dox
T7009 68-76 VBN denotes mediated
T7010 67-68 HYPH denotes -
T7011 88-90 IN denotes of
T7012 91-94 PRP$ denotes its
T7013 95-104 NN denotes precursor
T7014 105-111 NN denotes APPswe
T7015 112-115 NN denotes ind
T7016 111-112 HYPH denotes /
T7017 115-117 , denotes ,
T7018 117-119 PRP denotes we
T7019 129-133 NN denotes Aβ40
T7020 143-149 NNS denotes levels
T7021 134-137 CC denotes and
T7022 138-142 NN denotes Aβ42
T7023 150-152 IN denotes by
T7024 153-158 NN denotes ELISA
T7025 159-161 IN denotes in
T7026 162-171 NN denotes forebrain
T7027 172-183 NNS denotes homogenates
T7028 184-188 IN denotes from
T7029 189-194 JJ denotes young
T7030 203-210 NNS denotes animals
T7031 195-198 NN denotes tet
T7032 199-202 NN denotes off
T7033 198-199 HYPH denotes -
T7034 210-211 . denotes .
T7035 211-388 sentence denotes At 1 mo of age, the mice lacked visible amyloid aggregates that might act as an intractable reservoir of peptide remaining in the brain after the transgene had been suppressed.
T7036 212-214 IN denotes At
T7037 237-243 VBD denotes lacked
T7038 215-216 CD denotes 1
T7039 217-219 NN denotes mo
T7040 220-222 IN denotes of
T7041 223-226 NN denotes age
T7042 226-228 , denotes ,
T7043 228-231 DT denotes the
T7044 232-236 NNS denotes mice
T7045 244-251 JJ denotes visible
T7046 260-270 NNS denotes aggregates
T7047 252-259 NN denotes amyloid
T7048 271-275 WDT denotes that
T7049 282-285 VB denotes act
T7050 276-281 MD denotes might
T7051 286-288 IN denotes as
T7052 289-291 DT denotes an
T7053 304-313 NN denotes reservoir
T7054 292-303 JJ denotes intractable
T7055 314-316 IN denotes of
T7056 317-324 NN denotes peptide
T7057 325-334 VBG denotes remaining
T7058 335-337 IN denotes in
T7059 338-341 DT denotes the
T7060 342-347 NN denotes brain
T7061 348-353 IN denotes after
T7062 377-387 VBN denotes suppressed
T7063 354-357 DT denotes the
T7064 358-367 NN denotes transgene
T7065 368-371 VBD denotes had
T7066 372-376 VBN denotes been
T7067 387-388 . denotes .
T7068 388-634 sentence denotes To further ensure we could detect any such insoluble aggregates that might bias our measure of changes in peptide synthesis, we performed a sequential three-step extraction with PBS, 2% SDS, and 70% FA that would separate peptides by solubility.
T7069 389-391 TO denotes To
T7070 400-406 VB denotes ensure
T7071 392-399 RB denotes further
T7072 517-526 VBD denotes performed
T7073 407-409 PRP denotes we
T7074 416-422 VB denotes detect
T7075 410-415 MD denotes could
T7076 423-426 DT denotes any
T7077 442-452 NNS denotes aggregates
T7078 427-431 JJ denotes such
T7079 432-441 JJ denotes insoluble
T7080 453-457 WDT denotes that
T7081 464-468 VB denotes bias
T7082 458-463 MD denotes might
T7083 469-472 PRP$ denotes our
T7084 473-480 NN denotes measure
T7085 481-483 IN denotes of
T7086 484-491 NNS denotes changes
T7087 492-494 IN denotes in
T7088 495-502 NN denotes peptide
T7089 503-512 NN denotes synthesis
T7090 512-514 , denotes ,
T7091 514-516 PRP denotes we
T7092 527-528 DT denotes a
T7093 551-561 NN denotes extraction
T7094 529-539 JJ denotes sequential
T7095 540-545 CD denotes three
T7096 546-550 NN denotes step
T7097 545-546 HYPH denotes -
T7098 562-566 IN denotes with
T7099 567-570 NN denotes PBS
T7100 570-572 , denotes ,
T7101 572-573 CD denotes 2
T7102 573-574 NN denotes %
T7103 575-578 NN denotes SDS
T7104 578-580 , denotes ,
T7105 580-583 CC denotes and
T7106 584-586 CD denotes 70
T7107 586-587 NN denotes %
T7108 588-590 NN denotes FA
T7109 591-595 WDT denotes that
T7110 602-610 VB denotes separate
T7111 596-601 MD denotes would
T7112 611-619 NNS denotes peptides
T7113 620-622 IN denotes by
T7114 623-633 NN denotes solubility
T7115 633-634 . denotes .
T7116 634-977 sentence denotes We compared the levels of human transgene-derived Aβ40 and Aβ42 in untreated mice at 4 and 6 wk of age to animals that had either been born and raised on dox or that had been left untreated for 4 wk and then placed on dox chow for 2 wk prior to harvest (the same groups described above for immunoblot analysis of APPswe/ind levels, line 107).
T7117 635-637 PRP denotes We
T7118 638-646 VBD denotes compared
T7119 647-650 DT denotes the
T7120 651-657 NNS denotes levels
T7121 658-660 IN denotes of
T7122 661-666 JJ denotes human
T7123 667-676 NN denotes transgene
T7124 677-684 VBN denotes derived
T7125 676-677 HYPH denotes -
T7126 685-689 NN denotes Aβ40
T7127 690-693 CC denotes and
T7128 694-698 NN denotes Aβ42
T7129 699-701 IN denotes in
T7130 702-711 JJ denotes untreated
T7131 712-716 NNS denotes mice
T7132 717-719 IN denotes at
T7133 720-721 CD denotes 4
T7134 728-730 NN denotes wk
T7135 722-725 CC denotes and
T7136 726-727 CD denotes 6
T7137 731-733 IN denotes of
T7138 734-737 NN denotes age
T7139 738-740 IN denotes to
T7140 741-748 NNS denotes animals
T7141 749-753 WDT denotes that
T7142 770-774 VBN denotes born
T7143 754-757 VBD denotes had
T7144 758-764 CC denotes either
T7145 765-769 VBN denotes been
T7146 775-778 CC denotes and
T7147 779-785 VBN denotes raised
T7148 786-788 IN denotes on
T7149 789-792 NN denotes dox
T7150 793-795 CC denotes or
T7151 796-800 WDT denotes that
T7152 810-814 VBN denotes left
T7153 801-804 VBD denotes had
T7154 805-809 VBN denotes been
T7155 815-824 JJ denotes untreated
T7156 825-828 IN denotes for
T7157 829-830 CD denotes 4
T7158 831-833 NN denotes wk
T7159 834-837 CC denotes and
T7160 838-842 RB denotes then
T7161 843-849 VBN denotes placed
T7162 850-852 IN denotes on
T7163 853-856 NN denotes dox
T7164 857-861 NN denotes chow
T7165 862-865 IN denotes for
T7166 866-867 CD denotes 2
T7167 868-870 NN denotes wk
T7168 871-876 JJ denotes prior
T7169 877-879 IN denotes to
T7170 880-887 NN denotes harvest
T7171 888-889 -LRB- denotes (
T7172 967-971 NN denotes line
T7173 889-892 DT denotes the
T7174 898-904 NNS denotes groups
T7175 893-897 JJ denotes same
T7176 905-914 VBN denotes described
T7177 915-920 RB denotes above
T7178 921-924 IN denotes for
T7179 925-935 NN denotes immunoblot
T7180 936-944 NN denotes analysis
T7181 945-947 IN denotes of
T7182 948-954 NN denotes APPswe
T7183 955-958 NN denotes ind
T7184 954-955 HYPH denotes /
T7185 959-965 NNS denotes levels
T7186 965-967 , denotes ,
T7187 972-975 CD denotes 107
T7188 975-976 -RRB- denotes )
T7189 976-977 . denotes .
T7190 977-1253 sentence denotes Consistent with the reduction in full-length APPswe/ind synthesis shown by immunoblot (see Figure 1), we found that transgene-derived Aβ levels were completely suppressed in animals born and raised on dox, and were sharply reduced following acute (2 wk) antibiotic treatment.
T7191 978-988 JJ denotes Consistent
T7192 1083-1088 VBD denotes found
T7193 989-993 IN denotes with
T7194 994-997 DT denotes the
T7195 998-1007 NN denotes reduction
T7196 1008-1010 IN denotes in
T7197 1011-1015 JJ denotes full
T7198 1016-1022 NN denotes length
T7199 1015-1016 HYPH denotes -
T7200 1034-1043 NN denotes synthesis
T7201 1023-1029 NN denotes APPswe
T7202 1030-1033 NN denotes ind
T7203 1029-1030 HYPH denotes /
T7204 1044-1049 VBN denotes shown
T7205 1050-1052 IN denotes by
T7206 1053-1063 NN denotes immunoblot
T7207 1064-1065 -LRB- denotes (
T7208 1065-1068 VB denotes see
T7209 1069-1075 NN denotes Figure
T7210 1076-1077 CD denotes 1
T7211 1077-1078 -RRB- denotes )
T7212 1078-1080 , denotes ,
T7213 1080-1082 PRP denotes we
T7214 1089-1093 IN denotes that
T7215 1138-1148 VBN denotes suppressed
T7216 1094-1103 NN denotes transgene
T7217 1104-1111 VBN denotes derived
T7218 1103-1104 HYPH denotes -
T7219 1115-1121 NNS denotes levels
T7220 1112-1114 NN denotes Aβ
T7221 1122-1126 VBD denotes were
T7222 1127-1137 RB denotes completely
T7223 1149-1151 IN denotes in
T7224 1152-1159 NNS denotes animals
T7225 1160-1164 VBN denotes born
T7226 1165-1168 CC denotes and
T7227 1169-1175 VBN denotes raised
T7228 1176-1178 IN denotes on
T7229 1179-1182 NN denotes dox
T7230 1182-1184 , denotes ,
T7231 1184-1187 CC denotes and
T7232 1188-1192 VBD denotes were
T7233 1201-1208 VBN denotes reduced
T7234 1193-1200 RB denotes sharply
T7235 1209-1218 VBG denotes following
T7236 1219-1224 JJ denotes acute
T7237 1243-1252 NN denotes treatment
T7238 1225-1226 -LRB- denotes (
T7239 1228-1230 NN denotes wk
T7240 1226-1227 CD denotes 2
T7241 1230-1231 -RRB- denotes )
T7242 1232-1242 JJ denotes antibiotic
T7243 1252-1253 . denotes .
T7244 1253-1419 sentence denotes Compared to the levels in untreated 4-wk-old mice, PBS-soluble Aβ42 dropped by 95.2% following 2 wk of dox treatment and by 99.2% with chronic treatment (Figure 2A).
T7245 1254-1262 VBN denotes Compared
T7246 1322-1329 VBD denotes dropped
T7247 1263-1265 IN denotes to
T7248 1266-1269 DT denotes the
T7249 1270-1276 NNS denotes levels
T7250 1277-1279 IN denotes in
T7251 1280-1289 JJ denotes untreated
T7252 1299-1303 NNS denotes mice
T7253 1290-1291 CD denotes 4
T7254 1292-1294 NN denotes wk
T7255 1291-1292 HYPH denotes -
T7256 1295-1298 JJ denotes old
T7257 1294-1295 HYPH denotes -
T7258 1303-1305 , denotes ,
T7259 1305-1308 NN denotes PBS
T7260 1309-1316 JJ denotes soluble
T7261 1308-1309 HYPH denotes -
T7262 1317-1321 NN denotes Aβ42
T7263 1330-1332 IN denotes by
T7264 1333-1337 CD denotes 95.2
T7265 1337-1338 NN denotes %
T7266 1339-1348 VBG denotes following
T7267 1349-1350 CD denotes 2
T7268 1351-1353 NN denotes wk
T7269 1354-1356 IN denotes of
T7270 1357-1360 NN denotes dox
T7271 1361-1370 NN denotes treatment
T7272 1371-1374 CC denotes and
T7273 1375-1377 IN denotes by
T7274 1384-1388 IN denotes with
T7275 1378-1382 CD denotes 99.2
T7276 1382-1383 NN denotes %
T7277 1389-1396 JJ denotes chronic
T7278 1397-1406 NN denotes treatment
T7279 1407-1408 -LRB- denotes (
T7280 1415-1417 NN denotes 2A
T7281 1408-1414 NN denotes Figure
T7282 1417-1418 -RRB- denotes )
T7283 1418-1419 . denotes .
T7284 1419-1530 sentence denotes Similarly, SDS-soluble Aβ42 decreased by 75.2% and 94.8% following 2-wk or lifelong dox treatment (Figure 2B).
T7285 1420-1429 RB denotes Similarly
T7286 1448-1457 VBD denotes decreased
T7287 1429-1431 , denotes ,
T7288 1431-1434 NN denotes SDS
T7289 1435-1442 JJ denotes soluble
T7290 1434-1435 HYPH denotes -
T7291 1443-1447 NN denotes Aβ42
T7292 1458-1460 IN denotes by
T7293 1461-1465 CD denotes 75.2
T7294 1465-1466 NN denotes %
T7295 1467-1470 CC denotes and
T7296 1471-1475 CD denotes 94.8
T7297 1475-1476 NN denotes %
T7298 1477-1486 VBG denotes following
T7299 1487-1488 CD denotes 2
T7300 1489-1491 NN denotes wk
T7301 1488-1489 HYPH denotes -
T7302 1508-1517 NN denotes treatment
T7303 1492-1494 CC denotes or
T7304 1495-1503 JJ denotes lifelong
T7305 1504-1507 NN denotes dox
T7306 1518-1519 -LRB- denotes (
T7307 1526-1528 NN denotes 2B
T7308 1519-1525 NN denotes Figure
T7309 1528-1529 -RRB- denotes )
T7310 1529-1530 . denotes .
T7311 1530-1764 sentence denotes Only the FA fraction revealed a small dox-resistant pool of peptide in acutely treated animals that we believe represents stable predeposit aggregates that have already accumulated by 4 wk of age when treatment was begun (Figure 2C).
T7312 1531-1535 RB denotes Only
T7313 1543-1551 NN denotes fraction
T7314 1536-1539 DT denotes the
T7315 1540-1542 NN denotes FA
T7316 1552-1560 VBD denotes revealed
T7317 1561-1562 DT denotes a
T7318 1583-1587 NN denotes pool
T7319 1563-1568 JJ denotes small
T7320 1569-1572 NN denotes dox
T7321 1573-1582 JJ denotes resistant
T7322 1572-1573 HYPH denotes -
T7323 1588-1590 IN denotes of
T7324 1591-1598 NN denotes peptide
T7325 1599-1601 IN denotes in
T7326 1602-1609 RB denotes acutely
T7327 1610-1617 VBN denotes treated
T7328 1618-1625 NNS denotes animals
T7329 1626-1630 WDT denotes that
T7330 1634-1641 VBP denotes believe
T7331 1631-1633 PRP denotes we
T7332 1642-1652 VBZ denotes represents
T7333 1653-1659 JJ denotes stable
T7334 1671-1681 NNS denotes aggregates
T7335 1660-1670 JJ denotes predeposit
T7336 1682-1686 WDT denotes that
T7337 1700-1711 VBN denotes accumulated
T7338 1687-1691 VBP denotes have
T7339 1692-1699 RB denotes already
T7340 1712-1714 IN denotes by
T7341 1715-1716 CD denotes 4
T7342 1717-1719 NN denotes wk
T7343 1720-1722 IN denotes of
T7344 1723-1726 NN denotes age
T7345 1727-1731 WRB denotes when
T7346 1746-1751 VBN denotes begun
T7347 1732-1741 NN denotes treatment
T7348 1742-1745 VBD denotes was
T7349 1752-1753 -LRB- denotes (
T7350 1760-1762 NN denotes 2C
T7351 1753-1759 NN denotes Figure
T7352 1762-1763 -RRB- denotes )
T7353 1763-1764 . denotes .
T7354 1764-1926 sentence denotes Indeed, animals that were born and raised on dox did not harbor this reservoir of treatment-resistant peptide, with 96.3% less Aβ42 than untreated 4-wk-old mice.
T7355 1765-1771 RB denotes Indeed
T7356 1822-1828 VB denotes harbor
T7357 1771-1773 , denotes ,
T7358 1773-1780 NNS denotes animals
T7359 1781-1785 WDT denotes that
T7360 1791-1795 VBN denotes born
T7361 1786-1790 VBD denotes were
T7362 1796-1799 CC denotes and
T7363 1800-1806 VBN denotes raised
T7364 1807-1809 IN denotes on
T7365 1810-1813 NN denotes dox
T7366 1814-1817 VBD denotes did
T7367 1818-1821 RB denotes not
T7368 1829-1833 DT denotes this
T7369 1834-1843 NN denotes reservoir
T7370 1844-1846 IN denotes of
T7371 1847-1856 NN denotes treatment
T7372 1857-1866 JJ denotes resistant
T7373 1856-1857 HYPH denotes -
T7374 1867-1874 NN denotes peptide
T7375 1874-1876 , denotes ,
T7376 1876-1880 IN denotes with
T7377 1881-1885 CD denotes 96.3
T7378 1885-1886 NN denotes %
T7379 1887-1891 JJR denotes less
T7380 1892-1896 NN denotes Aβ42
T7381 1897-1901 IN denotes than
T7382 1902-1911 JJ denotes untreated
T7383 1921-1925 NNS denotes mice
T7384 1912-1913 CD denotes 4
T7385 1914-1916 NN denotes wk
T7386 1913-1914 HYPH denotes -
T7387 1917-1920 JJ denotes old
T7388 1916-1917 HYPH denotes -
T7389 1925-1926 . denotes .
T7390 1926-2171 sentence denotes Measurement of total Aβ in chronically treated mice, including endogenous and transgene-derived peptide, demonstrated that Aβ levels in tet-off APP mice were reduced to the level of endogenous peptide found in nontransgenic animals (Figure 2D).
T7391 1927-1938 NN denotes Measurement
T7392 2032-2044 VBD denotes demonstrated
T7393 1939-1941 IN denotes of
T7394 1942-1947 JJ denotes total
T7395 1948-1950 NN denotes Aβ
T7396 1951-1953 IN denotes in
T7397 1954-1965 RB denotes chronically
T7398 1966-1973 VBN denotes treated
T7399 1974-1978 NNS denotes mice
T7400 1978-1980 , denotes ,
T7401 1980-1989 VBG denotes including
T7402 1990-2000 JJ denotes endogenous
T7403 2023-2030 NN denotes peptide
T7404 2001-2004 CC denotes and
T7405 2005-2014 NN denotes transgene
T7406 2015-2022 VBN denotes derived
T7407 2014-2015 HYPH denotes -
T7408 2030-2032 , denotes ,
T7409 2045-2049 IN denotes that
T7410 2085-2092 VBN denotes reduced
T7411 2050-2052 NN denotes Aβ
T7412 2053-2059 NNS denotes levels
T7413 2060-2062 IN denotes in
T7414 2063-2066 NN denotes tet
T7415 2067-2070 NN denotes off
T7416 2066-2067 HYPH denotes -
T7417 2075-2079 NNS denotes mice
T7418 2071-2074 NN denotes APP
T7419 2080-2084 VBD denotes were
T7420 2093-2095 IN denotes to
T7421 2096-2099 DT denotes the
T7422 2100-2105 NN denotes level
T7423 2106-2108 IN denotes of
T7424 2109-2119 JJ denotes endogenous
T7425 2120-2127 NN denotes peptide
T7426 2128-2133 VBN denotes found
T7427 2134-2136 IN denotes in
T7428 2137-2150 JJ denotes nontransgenic
T7429 2151-2158 NNS denotes animals
T7430 2159-2160 -LRB- denotes (
T7431 2167-2169 NN denotes 2D
T7432 2160-2166 NN denotes Figure
T7433 2169-2170 -RRB- denotes )
T7434 2170-2171 . denotes .
T7435 2171-2382 sentence denotes Taken together with the immunoblotting data for full-length APPswe/ind, the ELISA measurements indicate that dox-mediated suppression of transgenic APPswe/ind synthesis leads to parallel reduction of Aβ levels.
T7436 2172-2177 VBN denotes Taken
T7437 2267-2275 VBP denotes indicate
T7438 2178-2186 RB denotes together
T7439 2187-2191 IN denotes with
T7440 2192-2195 DT denotes the
T7441 2211-2215 NNS denotes data
T7442 2196-2210 NN denotes immunoblotting
T7443 2216-2219 IN denotes for
T7444 2220-2224 JJ denotes full
T7445 2225-2231 NN denotes length
T7446 2224-2225 HYPH denotes -
T7447 2239-2242 NN denotes ind
T7448 2232-2238 NN denotes APPswe
T7449 2238-2239 HYPH denotes /
T7450 2242-2244 , denotes ,
T7451 2244-2247 DT denotes the
T7452 2254-2266 NNS denotes measurements
T7453 2248-2253 NN denotes ELISA
T7454 2276-2280 IN denotes that
T7455 2341-2346 VBZ denotes leads
T7456 2281-2284 NN denotes dox
T7457 2285-2293 VBN denotes mediated
T7458 2284-2285 HYPH denotes -
T7459 2294-2305 NN denotes suppression
T7460 2306-2308 IN denotes of
T7461 2309-2319 JJ denotes transgenic
T7462 2331-2340 NN denotes synthesis
T7463 2320-2326 NN denotes APPswe
T7464 2327-2330 NN denotes ind
T7465 2326-2327 HYPH denotes /
T7466 2347-2349 IN denotes to
T7467 2350-2358 JJ denotes parallel
T7468 2359-2368 NN denotes reduction
T7469 2369-2371 IN denotes of
T7470 2372-2374 NN denotes Aβ
T7471 2375-2381 NNS denotes levels
T7472 2381-2382 . denotes .
R4427 T6995 T6996 aux To,ensure
R4428 T6996 T6997 advcl ensure,measured
R4429 T6998 T6999 mark that,suppressed
R4430 T6999 T6996 ccomp suppressed,ensure
R4431 T7000 T7001 compound Aβ,production
R4432 T7001 T6999 nsubjpass production,suppressed
R4433 T7002 T6999 auxpass was,suppressed
R4434 T7003 T6999 prep in,suppressed
R4435 T7004 T7003 pobj concert,in
R4436 T7005 T7004 prep with,concert
R4437 T7006 T7007 det the,inhibition
R4438 T7007 T7005 pobj inhibition,with
R4439 T7008 T7009 npadvmod dox,mediated
R4440 T7009 T7007 amod mediated,inhibition
R4441 T7010 T7009 punct -,mediated
R4442 T7011 T7007 prep of,inhibition
R4443 T7012 T7013 poss its,precursor
R4444 T7013 T7011 pobj precursor,of
R4445 T7014 T7015 compound APPswe,ind
R4446 T7015 T7013 appos ind,precursor
R4447 T7016 T7015 punct /,ind
R4448 T7017 T6997 punct ", ",measured
R4449 T7018 T6997 nsubj we,measured
R4450 T7019 T7020 nmod Aβ40,levels
R4451 T7020 T6997 dobj levels,measured
R4452 T7021 T7019 cc and,Aβ40
R4453 T7022 T7019 conj Aβ42,Aβ40
R4454 T7023 T6997 prep by,measured
R4455 T7024 T7023 pobj ELISA,by
R4456 T7025 T6997 prep in,measured
R4457 T7026 T7027 compound forebrain,homogenates
R4458 T7027 T7025 pobj homogenates,in
R4459 T7028 T7027 prep from,homogenates
R4460 T7029 T7030 amod young,animals
R4461 T7030 T7028 pobj animals,from
R4462 T7031 T7032 compound tet,off
R4463 T7032 T7030 compound off,animals
R4464 T7033 T7032 punct -,off
R4465 T7034 T6997 punct .,measured
R4466 T7036 T7037 prep At,lacked
R4467 T7038 T7039 nummod 1,mo
R4468 T7039 T7036 pobj mo,At
R4469 T7040 T7039 prep of,mo
R4470 T7041 T7040 pobj age,of
R4471 T7042 T7037 punct ", ",lacked
R4472 T7043 T7044 det the,mice
R4473 T7044 T7037 nsubj mice,lacked
R4474 T7045 T7046 amod visible,aggregates
R4475 T7046 T7037 dobj aggregates,lacked
R4476 T7047 T7046 compound amyloid,aggregates
R4477 T7048 T7049 dep that,act
R4478 T7049 T7046 relcl act,aggregates
R4479 T7050 T7049 aux might,act
R4480 T7051 T7049 prep as,act
R4481 T7052 T7053 det an,reservoir
R4482 T7053 T7051 pobj reservoir,as
R4483 T7054 T7053 amod intractable,reservoir
R4484 T7055 T7053 prep of,reservoir
R4485 T7056 T7055 pobj peptide,of
R4486 T7057 T7053 acl remaining,reservoir
R4487 T7058 T7057 prep in,remaining
R4488 T7059 T7060 det the,brain
R4489 T7060 T7058 pobj brain,in
R4490 T7061 T7062 prep after,suppressed
R4491 T7062 T7057 advcl suppressed,remaining
R4492 T7063 T7064 det the,transgene
R4493 T7064 T7062 nsubjpass transgene,suppressed
R4494 T7065 T7062 aux had,suppressed
R4495 T7066 T7062 auxpass been,suppressed
R4496 T7067 T7037 punct .,lacked
R4497 T7069 T7070 aux To,ensure
R4498 T7070 T7072 advcl ensure,performed
R4499 T7071 T7070 advmod further,ensure
R4500 T7073 T7074 nsubj we,detect
R4501 T7074 T7070 advcl detect,ensure
R4502 T7075 T7074 aux could,detect
R4503 T7076 T7077 det any,aggregates
R4504 T7077 T7074 dobj aggregates,detect
R4505 T7078 T7077 amod such,aggregates
R4506 T7079 T7077 amod insoluble,aggregates
R4507 T7080 T7081 dep that,bias
R4508 T7081 T7077 relcl bias,aggregates
R4509 T7082 T7081 aux might,bias
R4510 T7083 T7084 poss our,measure
R4511 T7084 T7081 dobj measure,bias
R4512 T7085 T7084 prep of,measure
R4513 T7086 T7085 pobj changes,of
R4514 T7087 T7081 prep in,bias
R4515 T7088 T7089 compound peptide,synthesis
R4516 T7089 T7087 pobj synthesis,in
R4517 T7090 T7072 punct ", ",performed
R4518 T7091 T7072 nsubj we,performed
R4519 T7092 T7093 det a,extraction
R4520 T7093 T7072 dobj extraction,performed
R4521 T7094 T7093 amod sequential,extraction
R4522 T7095 T7096 nummod three,step
R4523 T7096 T7093 compound step,extraction
R4524 T7097 T7096 punct -,step
R4525 T7098 T7093 prep with,extraction
R4526 T7099 T7098 pobj PBS,with
R4527 T7100 T7099 punct ", ",PBS
R4528 T7101 T7102 nummod 2,%
R4529 T7102 T7103 compound %,SDS
R4530 T7103 T7099 conj SDS,PBS
R4531 T7104 T7103 punct ", ",SDS
R4532 T7105 T7103 cc and,SDS
R4533 T7106 T7107 nummod 70,%
R4534 T7107 T7108 compound %,FA
R4535 T7108 T7103 conj FA,SDS
R4536 T7109 T7110 dep that,separate
R4537 T7110 T7093 relcl separate,extraction
R4538 T7111 T7110 aux would,separate
R4539 T7112 T7110 dobj peptides,separate
R4540 T7113 T7110 prep by,separate
R4541 T7114 T7113 pobj solubility,by
R4542 T7115 T7072 punct .,performed
R4543 T7117 T7118 nsubj We,compared
R4544 T7119 T7120 det the,levels
R4545 T7120 T7118 dobj levels,compared
R4546 T7121 T7120 prep of,levels
R4547 T7122 T7123 amod human,transgene
R4548 T7123 T7124 npadvmod transgene,derived
R4549 T7124 T7126 amod derived,Aβ40
R4550 T7125 T7124 punct -,derived
R4551 T7126 T7121 pobj Aβ40,of
R4552 T7127 T7126 cc and,Aβ40
R4553 T7128 T7126 conj Aβ42,Aβ40
R4554 T7129 T7120 prep in,levels
R4555 T7130 T7131 amod untreated,mice
R4556 T7131 T7129 pobj mice,in
R4557 T7132 T7120 prep at,levels
R4558 T7133 T7134 nummod 4,wk
R4559 T7134 T7132 pobj wk,at
R4560 T7135 T7133 cc and,4
R4561 T7136 T7133 conj 6,4
R4562 T7137 T7134 prep of,wk
R4563 T7138 T7137 pobj age,of
R4564 T7139 T7118 prep to,compared
R4565 T7140 T7139 pobj animals,to
R4566 T7141 T7142 dep that,born
R4567 T7142 T7140 advcl born,animals
R4568 T7143 T7142 aux had,born
R4569 T7144 T7142 preconj either,born
R4570 T7145 T7142 auxpass been,born
R4571 T7146 T7142 cc and,born
R4572 T7147 T7142 conj raised,born
R4573 T7148 T7147 prep on,raised
R4574 T7149 T7148 pobj dox,on
R4575 T7150 T7142 cc or,born
R4576 T7151 T7152 dep that,left
R4577 T7152 T7142 conj left,born
R4578 T7153 T7152 aux had,left
R4579 T7154 T7152 auxpass been,left
R4580 T7155 T7152 oprd untreated,left
R4581 T7156 T7152 prep for,left
R4582 T7157 T7158 nummod 4,wk
R4583 T7158 T7156 pobj wk,for
R4584 T7159 T7152 cc and,left
R4585 T7160 T7161 advmod then,placed
R4586 T7161 T7152 conj placed,left
R4587 T7162 T7161 prep on,placed
R4588 T7163 T7164 compound dox,chow
R4589 T7164 T7162 pobj chow,on
R4590 T7165 T7161 prep for,placed
R4591 T7166 T7167 nummod 2,wk
R4592 T7167 T7165 pobj wk,for
R4593 T7168 T7169 amod prior,to
R4594 T7169 T7167 prep to,wk
R4595 T7170 T7169 pobj harvest,to
R4596 T7171 T7172 punct (,line
R4597 T7172 T7161 parataxis line,placed
R4598 T7173 T7174 det the,groups
R4599 T7174 T7172 dep groups,line
R4600 T7175 T7174 amod same,groups
R4601 T7176 T7174 acl described,groups
R4602 T7177 T7176 advmod above,described
R4603 T7178 T7176 prep for,described
R4604 T7179 T7180 compound immunoblot,analysis
R4605 T7180 T7178 pobj analysis,for
R4606 T7181 T7180 prep of,analysis
R4607 T7182 T7183 compound APPswe,ind
R4608 T7183 T7185 compound ind,levels
R4609 T7184 T7183 punct /,ind
R4610 T7185 T7181 pobj levels,of
R4611 T7186 T7172 punct ", ",line
R4612 T7187 T7172 nummod 107,line
R4613 T7188 T7172 punct ),line
R4614 T7189 T7118 punct .,compared
R4615 T7191 T7192 advcl Consistent,found
R4616 T7193 T7191 prep with,Consistent
R4617 T7194 T7195 det the,reduction
R4618 T7195 T7193 pobj reduction,with
R4619 T7196 T7195 prep in,reduction
R4620 T7197 T7198 amod full,length
R4621 T7198 T7200 compound length,synthesis
R4622 T7199 T7198 punct -,length
R4623 T7200 T7196 pobj synthesis,in
R4624 T7201 T7202 compound APPswe,ind
R4625 T7202 T7200 compound ind,synthesis
R4626 T7203 T7202 punct /,ind
R4627 T7204 T7195 acl shown,reduction
R4628 T7205 T7204 agent by,shown
R4629 T7206 T7205 pobj immunoblot,by
R4630 T7207 T7208 punct (,see
R4631 T7208 T7191 parataxis see,Consistent
R4632 T7209 T7208 dobj Figure,see
R4633 T7210 T7209 nummod 1,Figure
R4634 T7211 T7208 punct ),see
R4635 T7212 T7192 punct ", ",found
R4636 T7213 T7192 nsubj we,found
R4637 T7214 T7215 mark that,suppressed
R4638 T7215 T7192 ccomp suppressed,found
R4639 T7216 T7217 npadvmod transgene,derived
R4640 T7217 T7219 amod derived,levels
R4641 T7218 T7217 punct -,derived
R4642 T7219 T7215 nsubjpass levels,suppressed
R4643 T7220 T7219 compound Aβ,levels
R4644 T7221 T7215 auxpass were,suppressed
R4645 T7222 T7215 advmod completely,suppressed
R4646 T7223 T7215 prep in,suppressed
R4647 T7224 T7223 pobj animals,in
R4648 T7225 T7224 acl born,animals
R4649 T7226 T7225 cc and,born
R4650 T7227 T7225 conj raised,born
R4651 T7228 T7227 prep on,raised
R4652 T7229 T7228 pobj dox,on
R4653 T7230 T7215 punct ", ",suppressed
R4654 T7231 T7215 cc and,suppressed
R4655 T7232 T7233 auxpass were,reduced
R4656 T7233 T7215 conj reduced,suppressed
R4657 T7234 T7233 advmod sharply,reduced
R4658 T7235 T7233 prep following,reduced
R4659 T7236 T7237 amod acute,treatment
R4660 T7237 T7235 pobj treatment,following
R4661 T7238 T7239 punct (,wk
R4662 T7239 T7236 parataxis wk,acute
R4663 T7240 T7239 nummod 2,wk
R4664 T7241 T7239 punct ),wk
R4665 T7242 T7237 amod antibiotic,treatment
R4666 T7243 T7192 punct .,found
R4667 T7245 T7246 prep Compared,dropped
R4668 T7247 T7245 prep to,Compared
R4669 T7248 T7249 det the,levels
R4670 T7249 T7247 pobj levels,to
R4671 T7250 T7249 prep in,levels
R4672 T7251 T7252 amod untreated,mice
R4673 T7252 T7250 pobj mice,in
R4674 T7253 T7254 nummod 4,wk
R4675 T7254 T7256 npadvmod wk,old
R4676 T7255 T7254 punct -,wk
R4677 T7256 T7252 amod old,mice
R4678 T7257 T7256 punct -,old
R4679 T7258 T7246 punct ", ",dropped
R4680 T7259 T7260 npadvmod PBS,soluble
R4681 T7260 T7262 amod soluble,Aβ42
R4682 T7261 T7260 punct -,soluble
R4683 T7262 T7246 nsubj Aβ42,dropped
R4684 T7263 T7246 prep by,dropped
R4685 T7264 T7265 nummod 95.2,%
R4686 T7265 T7263 pobj %,by
R4687 T7266 T7246 prep following,dropped
R4688 T7267 T7268 nummod 2,wk
R4689 T7268 T7266 pobj wk,following
R4690 T7269 T7268 prep of,wk
R4691 T7270 T7271 compound dox,treatment
R4692 T7271 T7269 pobj treatment,of
R4693 T7272 T7246 cc and,dropped
R4694 T7273 T7274 prep by,with
R4695 T7274 T7246 conj with,dropped
R4696 T7275 T7276 nummod 99.2,%
R4697 T7276 T7273 pobj %,by
R4698 T7277 T7278 amod chronic,treatment
R4699 T7278 T7274 pobj treatment,with
R4700 T7279 T7280 punct (,2A
R4701 T7280 T7274 parataxis 2A,with
R4702 T7281 T7280 compound Figure,2A
R4703 T7282 T7280 punct ),2A
R4704 T7283 T7246 punct .,dropped
R4705 T7285 T7286 advmod Similarly,decreased
R4706 T7287 T7286 punct ", ",decreased
R4707 T7288 T7289 npadvmod SDS,soluble
R4708 T7289 T7291 amod soluble,Aβ42
R4709 T7290 T7289 punct -,soluble
R4710 T7291 T7286 nsubj Aβ42,decreased
R4711 T7292 T7286 prep by,decreased
R4712 T7293 T7294 nummod 75.2,%
R4713 T7294 T7292 pobj %,by
R4714 T7295 T7294 cc and,%
R4715 T7296 T7297 nummod 94.8,%
R4716 T7297 T7294 conj %,%
R4717 T7298 T7286 prep following,decreased
R4718 T7299 T7300 nummod 2,wk
R4719 T7300 T7302 nmod wk,treatment
R4720 T7301 T7300 punct -,wk
R4721 T7302 T7298 pobj treatment,following
R4722 T7303 T7300 cc or,wk
R4723 T7304 T7300 conj lifelong,wk
R4724 T7305 T7302 compound dox,treatment
R4725 T7306 T7307 punct (,2B
R4726 T7307 T7286 parataxis 2B,decreased
R4727 T7308 T7307 compound Figure,2B
R4728 T7309 T7307 punct ),2B
R4729 T7310 T7286 punct .,decreased
R4730 T7312 T7313 advmod Only,fraction
R4731 T7313 T7316 nsubj fraction,revealed
R4732 T7314 T7313 det the,fraction
R4733 T7315 T7313 compound FA,fraction
R4734 T7317 T7318 det a,pool
R4735 T7318 T7316 dobj pool,revealed
R4736 T7319 T7318 amod small,pool
R4737 T7320 T7321 npadvmod dox,resistant
R4738 T7321 T7318 amod resistant,pool
R4739 T7322 T7321 punct -,resistant
R4740 T7323 T7318 prep of,pool
R4741 T7324 T7323 pobj peptide,of
R4742 T7325 T7318 prep in,pool
R4743 T7326 T7327 advmod acutely,treated
R4744 T7327 T7328 amod treated,animals
R4745 T7328 T7325 pobj animals,in
R4746 T7329 T7330 dep that,believe
R4747 T7330 T7318 relcl believe,pool
R4748 T7331 T7330 nsubj we,believe
R4749 T7332 T7330 advcl represents,believe
R4750 T7333 T7334 amod stable,aggregates
R4751 T7334 T7332 dobj aggregates,represents
R4752 T7335 T7334 amod predeposit,aggregates
R4753 T7336 T7337 dep that,accumulated
R4754 T7337 T7334 relcl accumulated,aggregates
R4755 T7338 T7337 aux have,accumulated
R4756 T7339 T7337 advmod already,accumulated
R4757 T7340 T7337 prep by,accumulated
R4758 T7341 T7342 nummod 4,wk
R4759 T7342 T7340 pobj wk,by
R4760 T7343 T7342 prep of,wk
R4761 T7344 T7343 pobj age,of
R4762 T7345 T7346 advmod when,begun
R4763 T7346 T7337 advcl begun,accumulated
R4764 T7347 T7346 nsubjpass treatment,begun
R4765 T7348 T7346 auxpass was,begun
R4766 T7349 T7350 punct (,2C
R4767 T7350 T7316 parataxis 2C,revealed
R4768 T7351 T7350 compound Figure,2C
R4769 T7352 T7350 punct ),2C
R4770 T7353 T7316 punct .,revealed
R4771 T7355 T7356 advmod Indeed,harbor
R4772 T7357 T7356 punct ", ",harbor
R4773 T7358 T7356 nsubj animals,harbor
R4774 T7359 T7360 dep that,born
R4775 T7360 T7358 relcl born,animals
R4776 T7361 T7360 auxpass were,born
R4777 T7362 T7360 cc and,born
R4778 T7363 T7360 conj raised,born
R4779 T7364 T7363 prep on,raised
R4780 T7365 T7364 pobj dox,on
R4781 T7366 T7356 aux did,harbor
R4782 T7367 T7356 neg not,harbor
R4783 T7368 T7369 det this,reservoir
R4784 T7369 T7356 dobj reservoir,harbor
R4785 T7370 T7369 prep of,reservoir
R4786 T7371 T7372 npadvmod treatment,resistant
R4787 T7372 T7374 amod resistant,peptide
R4788 T7373 T7372 punct -,resistant
R4789 T7374 T7370 pobj peptide,of
R4790 T7375 T7356 punct ", ",harbor
R4791 T7376 T7356 prep with,harbor
R4792 T7377 T7378 nummod 96.3,%
R4793 T7378 T7379 npadvmod %,less
R4794 T7379 T7380 amod less,Aβ42
R4795 T7380 T7376 pobj Aβ42,with
R4796 T7381 T7380 prep than,Aβ42
R4797 T7382 T7383 amod untreated,mice
R4798 T7383 T7381 pobj mice,than
R4799 T7384 T7385 nummod 4,wk
R4800 T7385 T7387 npadvmod wk,old
R4801 T7386 T7385 punct -,wk
R4802 T7387 T7383 amod old,mice
R4803 T7388 T7387 punct -,old
R4804 T7389 T7356 punct .,harbor
R4805 T7391 T7392 nsubj Measurement,demonstrated
R4806 T7393 T7391 prep of,Measurement
R4807 T7394 T7395 amod total,Aβ
R4808 T7395 T7393 pobj Aβ,of
R4809 T7396 T7391 prep in,Measurement
R4810 T7397 T7398 advmod chronically,treated
R4811 T7398 T7399 amod treated,mice
R4812 T7399 T7396 pobj mice,in
R4813 T7400 T7391 punct ", ",Measurement
R4814 T7401 T7391 prep including,Measurement
R4815 T7402 T7403 amod endogenous,peptide
R4816 T7403 T7401 pobj peptide,including
R4817 T7404 T7402 cc and,endogenous
R4818 T7405 T7406 npadvmod transgene,derived
R4819 T7406 T7402 conj derived,endogenous
R4820 T7407 T7406 punct -,derived
R4821 T7408 T7392 punct ", ",demonstrated
R4822 T7409 T7410 mark that,reduced
R4823 T7410 T7392 ccomp reduced,demonstrated
R4824 T7411 T7412 compound Aβ,levels
R4825 T7412 T7410 nsubjpass levels,reduced
R4826 T7413 T7412 prep in,levels
R4827 T7414 T7415 compound tet,off
R4828 T7415 T7417 compound off,mice
R4829 T7416 T7415 punct -,off
R4830 T7417 T7413 pobj mice,in
R4831 T7418 T7417 compound APP,mice
R4832 T7419 T7410 auxpass were,reduced
R4833 T7420 T7410 prep to,reduced
R4834 T7421 T7422 det the,level
R4835 T7422 T7420 pobj level,to
R4836 T7423 T7422 prep of,level
R4837 T7424 T7425 amod endogenous,peptide
R4838 T7425 T7423 pobj peptide,of
R4839 T7426 T7422 acl found,level
R4840 T7427 T7426 prep in,found
R4841 T7428 T7429 amod nontransgenic,animals
R4842 T7429 T7427 pobj animals,in
R4843 T7430 T7431 punct (,2D
R4844 T7431 T7410 parataxis 2D,reduced
R4845 T7432 T7431 compound Figure,2D
R4846 T7433 T7431 punct ),2D
R4847 T7434 T7392 punct .,demonstrated
R4848 T7436 T7437 advcl Taken,indicate
R4849 T7438 T7436 advmod together,Taken
R4850 T7439 T7436 prep with,Taken
R4851 T7440 T7441 det the,data
R4852 T7441 T7439 pobj data,with
R4853 T7442 T7441 compound immunoblotting,data
R4854 T7443 T7441 prep for,data
R4855 T7444 T7445 amod full,length
R4856 T7445 T7447 compound length,ind
R4857 T7446 T7445 punct -,length
R4858 T7447 T7443 pobj ind,for
R4859 T7448 T7447 compound APPswe,ind
R4860 T7449 T7447 punct /,ind
R4861 T7450 T7437 punct ", ",indicate
R4862 T7451 T7452 det the,measurements
R4863 T7452 T7437 nsubj measurements,indicate
R4864 T7453 T7452 compound ELISA,measurements
R4865 T7454 T7455 mark that,leads
R4866 T7455 T7437 ccomp leads,indicate
R4868 T7456 T7457 npadvmod dox,mediated
R4871 T7457 T7459 amod mediated,suppression
R4875 T7458 T7457 punct -,mediated
R4878 T7459 T7455 nsubj suppression,leads
R4881 T7460 T7459 prep of,suppression
R4885 T7461 T7462 amod transgenic,synthesis
R4887 T7462 T7460 pobj synthesis,of
R4889 T7463 T7464 compound APPswe,ind
R4893 T7464 T7462 compound ind,synthesis
R4897 T7465 T7464 punct /,ind
R4903 T7466 T7455 prep to,leads
R4907 T7467 T7468 amod parallel,reduction
R4909 T7468 T7466 pobj reduction,to
R4914 T7469 T7468 prep of,reduction
R4918 T7470 T7471 compound Aβ,levels
R4922 T7471 T7469 pobj levels,of
R4925 T7472 T7437 punct .,indicate

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6187 15-17 CHEBI_PR_EXT:amyloid_beta denotes Aβ
T6188 15-28 GO:0034205 denotes Aβ production
T6189 64-67 CHEBI:50845 denotes dox
T6190 129-133 CHEBI_PR_EXT:amyloid_beta_40 denotes Aβ40
T6191 138-142 CHEBI_PR_EXT:amyloid_beta_42 denotes Aβ42
T6192 162-171 UBERON:0001890 denotes forebrain
T6193 203-210 NCBITaxon:33208 denotes animals
T6194 232-236 NCBITaxon:10088 denotes mice
T6195 252-259 CHEBI:60425 denotes amyloid
T6196 317-324 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T6197 342-347 UBERON:0000955 denotes brain
T6198 358-367 SO_EXT:0000902 denotes transgene
T6199 495-502 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T6200 495-512 GO:0043043 denotes peptide synthesis
T6201 575-578 CHEBI:8984 denotes SDS
T6202 588-590 CHEBI:30751 denotes FA
T6203 611-619 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptides
T6204 661-666 NCBITaxon:9606 denotes human
T6205 667-676 SO_EXT:0000902 denotes transgene
T6206 685-689 CHEBI_PR_EXT:amyloid_beta_40 denotes Aβ40
T6207 694-698 CHEBI_PR_EXT:amyloid_beta_42 denotes Aβ42
T6208 712-716 NCBITaxon:10088 denotes mice
T6209 741-748 NCBITaxon:33208 denotes animals
T6210 770-774 GO:0007567 denotes born
T6211 789-792 CHEBI:50845 denotes dox
T6212 853-856 CHEBI:50845 denotes dox
T6213 857-861 CHEBI_EXT:33290 denotes chow
T6214 1094-1103 SO_EXT:0000902 denotes transgene
T6215 1112-1114 CHEBI_PR_EXT:amyloid_beta denotes Aβ
T6216 1152-1159 NCBITaxon:33208 denotes animals
T6217 1160-1164 GO:0007567 denotes born
T6218 1179-1182 CHEBI:50845 denotes dox
T6219 1232-1242 CHEBI_EXT:33282 denotes antibiotic
T6220 1299-1303 NCBITaxon:10088 denotes mice
T6221 1317-1321 CHEBI_PR_EXT:amyloid_beta_42 denotes Aβ42
T6222 1357-1360 CHEBI:50845 denotes dox
T6223 1431-1434 CHEBI:8984 denotes SDS
T6224 1443-1447 CHEBI_PR_EXT:amyloid_beta_42 denotes Aβ42
T6225 1504-1507 CHEBI:50845 denotes dox
T6226 1540-1542 CHEBI:30751 denotes FA
T6227 1569-1572 CHEBI:50845 denotes dox
T6228 1591-1598 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T6229 1618-1625 NCBITaxon:33208 denotes animals
T6230 1773-1780 NCBITaxon:33208 denotes animals
T6231 1791-1795 GO:0007567 denotes born
T6232 1810-1813 CHEBI:50845 denotes dox
T6233 1867-1874 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T6234 1892-1896 CHEBI_PR_EXT:amyloid_beta_42 denotes Aβ42
T6235 1921-1925 NCBITaxon:10088 denotes mice
T6236 1948-1950 CHEBI_PR_EXT:amyloid_beta denotes Aβ
T6237 1974-1978 NCBITaxon:10088 denotes mice
T6238 2005-2014 SO_EXT:0000902 denotes transgene
T6239 2023-2030 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T6240 2050-2052 CHEBI_PR_EXT:amyloid_beta denotes Aβ
T6241 2071-2074 PR_EXT:000004168 denotes APP
T6242 2075-2079 NCBITaxon:10088 denotes mice
T6243 2120-2127 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T6244 2140-2150 SO_EXT:transgenic_entity denotes transgenic
T6245 2151-2158 NCBITaxon:33208 denotes animals
T6246 2281-2284 CHEBI:50845 denotes dox
T6247 2309-2319 SO_EXT:transgenic_entity denotes transgenic
T6248 2372-2374 CHEBI_PR_EXT:amyloid_beta denotes Aβ

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T5877 15-28 GO:0034205 denotes Aβ production
T5878 64-67 CHEBI:50845 denotes dox
T5879 162-171 UBERON:0001890 denotes forebrain
T5880 203-210 NCBITaxon:33208 denotes animals
T5881 232-236 NCBITaxon:10088 denotes mice
T5882 252-259 CHEBI:60425 denotes amyloid
T5883 342-347 UBERON:0000955 denotes brain
T5884 358-367 SO:0000902 denotes transgene
T5885 495-512 GO:0043043 denotes peptide synthesis
T5886 575-578 CHEBI:8984 denotes SDS
T5887 588-590 CHEBI:30751 denotes FA
T5888 661-666 NCBITaxon:9606 denotes human
T5889 667-676 SO:0000902 denotes transgene
T5890 712-716 NCBITaxon:10088 denotes mice
T5891 741-748 NCBITaxon:33208 denotes animals
T5892 770-774 GO:0007567 denotes born
T5893 789-792 CHEBI:50845 denotes dox
T5894 853-856 CHEBI:50845 denotes dox
T5895 857-861 CHEBI:33290 denotes chow
T5896 1094-1103 SO:0000902 denotes transgene
T5897 1152-1159 NCBITaxon:33208 denotes animals
T5898 1160-1164 GO:0007567 denotes born
T5899 1179-1182 CHEBI:50845 denotes dox
T5900 1232-1242 CHEBI:33282 denotes antibiotic
T5901 1299-1303 NCBITaxon:10088 denotes mice
T5902 1357-1360 CHEBI:50845 denotes dox
T5903 1431-1434 CHEBI:8984 denotes SDS
T5904 1504-1507 CHEBI:50845 denotes dox
T5905 1540-1542 CHEBI:30751 denotes FA
T5906 1569-1572 CHEBI:50845 denotes dox
T5907 1618-1625 NCBITaxon:33208 denotes animals
T5908 1773-1780 NCBITaxon:33208 denotes animals
T5909 1791-1795 GO:0007567 denotes born
T5910 1810-1813 CHEBI:50845 denotes dox
T5911 1921-1925 NCBITaxon:10088 denotes mice
T5912 1974-1978 NCBITaxon:10088 denotes mice
T5913 2005-2014 SO:0000902 denotes transgene
T5914 2071-2074 PR:000004168 denotes APP
T5915 2075-2079 NCBITaxon:10088 denotes mice
T5916 2151-2158 NCBITaxon:33208 denotes animals
T5917 2281-2284 CHEBI:50845 denotes dox