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PMC:1283364 / 154-723 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T152 0-10 sentence denotes Background
T153 0-10 NN denotes Background
T154 10-219 sentence denotes The proteases (secretases) that cleave amyloid-β (Aβ) peptide from the amyloid precursor protein (APP) have been the focus of considerable investigation in the development of treatments for Alzheimer disease.
T155 11-14 DT denotes The
T156 26-36 NNS denotes secretases
T157 15-24 NNS denotes proteases
T158 25-26 -LRB- denotes (
T159 119-123 VBN denotes been
T160 36-37 -RRB- denotes )
T161 38-42 WDT denotes that
T162 43-49 VBP denotes cleave
T163 50-57 NN denotes amyloid
T164 58-59 NN denotes β
T165 57-58 HYPH denotes -
T166 65-72 NN denotes peptide
T167 60-61 -LRB- denotes (
T168 61-63 NN denotes Aβ
T169 63-64 -RRB- denotes )
T170 73-77 IN denotes from
T171 78-81 DT denotes the
T172 100-107 NN denotes protein
T173 82-89 NN denotes amyloid
T174 90-99 NN denotes precursor
T175 108-109 -LRB- denotes (
T176 109-112 NN denotes APP
T177 112-113 -RRB- denotes )
T178 114-118 VBP denotes have
T179 124-127 DT denotes the
T180 128-133 NN denotes focus
T181 134-136 IN denotes of
T182 137-149 JJ denotes considerable
T183 150-163 NN denotes investigation
T184 164-166 IN denotes in
T185 167-170 DT denotes the
T186 171-182 NN denotes development
T187 183-185 IN denotes of
T188 186-196 NNS denotes treatments
T189 197-200 IN denotes for
T190 201-210 NNP denotes Alzheimer
T191 211-218 NN denotes disease
T192 218-219 . denotes .
T193 219-449 sentence denotes The prediction has been that reducing Aβ production in the brain, even after the onset of clinical symptoms and the development of associated pathology, will facilitate the repair of damaged tissue and removal of amyloid lesions.
T194 220-223 DT denotes The
T195 224-234 NN denotes prediction
T196 239-243 VBN denotes been
T197 235-238 VBZ denotes has
T198 244-248 IN denotes that
T199 378-388 VB denotes facilitate
T200 249-257 VBG denotes reducing
T201 258-260 NN denotes Aβ
T202 261-271 NN denotes production
T203 272-274 IN denotes in
T204 275-278 DT denotes the
T205 279-284 NN denotes brain
T206 284-286 , denotes ,
T207 286-290 RB denotes even
T208 291-296 IN denotes after
T209 297-300 DT denotes the
T210 301-306 NN denotes onset
T211 307-309 IN denotes of
T212 310-318 JJ denotes clinical
T213 319-327 NNS denotes symptoms
T214 328-331 CC denotes and
T215 332-335 DT denotes the
T216 336-347 NN denotes development
T217 348-350 IN denotes of
T218 351-361 VBN denotes associated
T219 362-371 NN denotes pathology
T220 371-373 , denotes ,
T221 373-377 MD denotes will
T222 389-392 DT denotes the
T223 393-399 NN denotes repair
T224 400-402 IN denotes of
T225 403-410 VBN denotes damaged
T226 411-417 NN denotes tissue
T227 418-421 CC denotes and
T228 422-429 NN denotes removal
T229 430-432 IN denotes of
T230 433-440 NN denotes amyloid
T231 441-448 NNS denotes lesions
T232 448-449 . denotes .
T233 449-569 sentence denotes However, no long-term studies using animal models of amyloid pathology have yet been performed to test this hypothesis.
T234 450-457 RB denotes However
T235 535-544 VBN denotes performed
T236 457-459 , denotes ,
T237 459-461 DT denotes no
T238 472-479 NNS denotes studies
T239 462-466 JJ denotes long
T240 467-471 NN denotes term
T241 466-467 HYPH denotes -
T242 480-485 VBG denotes using
T243 486-492 NN denotes animal
T244 493-499 NNS denotes models
T245 500-502 IN denotes of
T246 503-510 NN denotes amyloid
T247 511-520 NN denotes pathology
T248 521-525 VBP denotes have
T249 526-529 RB denotes yet
T250 530-534 VBN denotes been
T251 545-547 TO denotes to
T252 548-552 VB denotes test
T253 553-557 DT denotes this
T254 558-568 NN denotes hypothesis
T255 568-569 . denotes .
R15 T156 T159 nsubj secretases,been
R16 T157 T156 nmod proteases,secretases
R17 T158 T156 punct (,secretases
R22 T164 T166 nmod β,peptide
R23 T165 T164 punct -,β
R24 T166 T162 dobj peptide,cleave
R25 T167 T164 punct (,β
R26 T168 T164 appos Aβ,β
R27 T169 T166 punct ),peptide
R30 T172 T170 pobj protein,from
R31 T173 T172 compound amyloid,protein
R32 T174 T172 compound precursor,protein
R55 T199 T196 ccomp facilitate,been
R56 T200 T199 csubj reducing,facilitate
R57 T201 T202 compound Aβ,production
R58 T202 T200 dobj production,reducing
R59 T203 T200 prep in,reducing
R60 T204 T205 det the,brain
R61 T205 T203 pobj brain,in
R62 T206 T199 punct ", ",facilitate
R63 T207 T208 advmod even,after
R64 T208 T199 prep after,facilitate
R65 T209 T210 det the,onset
R66 T210 T208 pobj onset,after
R67 T211 T210 prep of,onset
R68 T212 T213 amod clinical,symptoms
R69 T213 T211 pobj symptoms,of
R70 T214 T210 cc and,onset
R71 T215 T216 det the,development
R72 T216 T210 conj development,onset
R73 T217 T216 prep of,development
R74 T218 T219 amod associated,pathology
R75 T219 T217 pobj pathology,of
R76 T220 T199 punct ", ",facilitate
R77 T221 T199 aux will,facilitate
R92 T238 T235 nsubjpass studies,performed
R93 T239 T240 amod long,term
R95 T241 T240 punct -,term
R14 T155 T156 det The,secretases
R18 T160 T156 punct ),secretases
R19 T161 T162 dep that,cleave
R20 T162 T156 relcl cleave,secretases
R21 T163 T164 nmod amyloid,β
R28 T170 T162 prep from,cleave
R29 T171 T172 det the,protein
R33 T175 T172 punct (,protein
R34 T176 T172 appos APP,protein
R35 T177 T159 punct ),been
R36 T178 T159 aux have,been
R37 T179 T180 det the,focus
R38 T180 T159 attr focus,been
R39 T181 T180 prep of,focus
R40 T182 T183 amod considerable,investigation
R41 T183 T181 pobj investigation,of
R42 T184 T183 prep in,investigation
R43 T185 T186 det the,development
R44 T186 T184 pobj development,in
R45 T187 T186 prep of,development
R46 T188 T187 pobj treatments,of
R47 T189 T188 prep for,treatments
R48 T190 T191 compound Alzheimer,disease
R49 T191 T189 pobj disease,for
R50 T192 T159 punct .,been
R51 T194 T195 det The,prediction
R52 T195 T196 nsubj prediction,been
R53 T197 T196 aux has,been
R54 T198 T199 mark that,facilitate
R78 T222 T223 det the,repair
R79 T223 T199 dobj repair,facilitate
R80 T224 T223 prep of,repair
R81 T225 T226 amod damaged,tissue
R82 T226 T224 pobj tissue,of
R83 T227 T223 cc and,repair
R84 T228 T223 conj removal,repair
R85 T229 T228 prep of,removal
R86 T230 T231 compound amyloid,lesions
R87 T231 T229 pobj lesions,of
R88 T232 T196 punct .,been
R89 T234 T235 advmod However,performed
R90 T236 T235 punct ", ",performed
R91 T237 T238 det no,studies
R94 T240 T238 compound term,studies
R96 T242 T238 acl using,studies
R97 T243 T244 compound animal,models
R98 T244 T242 dobj models,using
R99 T245 T244 prep of,models
R100 T246 T247 compound amyloid,pathology
R101 T247 T245 pobj pathology,of
R102 T248 T235 aux have,performed
R103 T249 T235 advmod yet,performed
R104 T250 T235 auxpass been,performed
R105 T251 T252 aux to,test
R106 T252 T235 advcl test,performed
R107 T253 T254 det this,hypothesis
R108 T254 T252 dobj hypothesis,test
R109 T255 T235 punct .,performed

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T78 15-24 GO_EXT:0008233 denotes proteases
T79 43-49 MOP:0000780 denotes cleave
T80 50-59 CHEBI_PR_EXT:amyloid_beta denotes amyloid-β
T81 61-63 CHEBI_PR_EXT:amyloid_beta denotes Aβ
T82 61-63 _FRAGMENT denotes Aβ
T83 65-72 CHEBI_PR_EXT:amyloid_beta denotes peptide
T84 65-72 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T85 82-89 CHEBI_PR_EXT:amyloid_beta denotes amyloid
T86 82-107 PR_EXT:000004168 denotes amyloid precursor protein
T87 100-107 CHEBI_PR_EXT:protein denotes protein
T88 109-112 PR_EXT:000004168 denotes APP
T89 258-260 CHEBI_PR_EXT:amyloid_beta denotes Aβ
T90 258-271 GO:0034205 denotes Aβ production
T91 279-284 UBERON:0000955 denotes brain
T92 411-417 UBERON:0000479 denotes tissue
T93 433-440 CHEBI:60425 denotes amyloid
T94 486-492 NCBITaxon:33208 denotes animal
T95 503-510 CHEBI:60425 denotes amyloid
R1 T83 T82 _lexicallyChainedTo peptide,Aβ

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T37 43-49 MOP:0000780 denotes cleave
T38 82-107 PR:000004168 denotes amyloid precursor protein
T39 109-112 PR:000004168 denotes APP
T40 258-271 GO:0034205 denotes Aβ production
T41 279-284 UBERON:0000955 denotes brain
T42 411-417 UBERON:0000479 denotes tissue
T43 433-440 CHEBI:60425 denotes amyloid
T44 486-492 NCBITaxon:33208 denotes animal
T45 503-510 CHEBI:60425 denotes amyloid