PMC:1283364 / 1056-1375
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1283364","sourcedb":"PMC","sourceid":"1283364","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1283364","text":"t amyloid pathology. We show that doxycycline administration inhibits transgenic APP expression by greater than 95% and reduces Aβ production to levels found in nontransgenic mice. Suppression of transgenic Aβ synthesis in this model abruptly halts the progression of amyloid pathology. However, formation and disaggreg","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T313","span":{"begin":10,"end":19},"obj":"NN"},{"id":"T314","span":{"begin":2,"end":9},"obj":"NN"},{"id":"T315","span":{"begin":19,"end":20},"obj":"."},{"id":"T316","span":{"begin":20,"end":180},"obj":"sentence"},{"id":"T317","span":{"begin":21,"end":23},"obj":"PRP"},{"id":"T318","span":{"begin":24,"end":28},"obj":"VBP"},{"id":"T319","span":{"begin":29,"end":33},"obj":"IN"},{"id":"T320","span":{"begin":61,"end":69},"obj":"VBZ"},{"id":"T321","span":{"begin":34,"end":45},"obj":"NN"},{"id":"T322","span":{"begin":46,"end":60},"obj":"NN"},{"id":"T323","span":{"begin":70,"end":80},"obj":"JJ"},{"id":"T324","span":{"begin":85,"end":95},"obj":"NN"},{"id":"T325","span":{"begin":81,"end":84},"obj":"NN"},{"id":"T326","span":{"begin":96,"end":98},"obj":"IN"},{"id":"T327","span":{"begin":99,"end":106},"obj":"JJR"},{"id":"T328","span":{"begin":112,"end":114},"obj":"CD"},{"id":"T329","span":{"begin":107,"end":111},"obj":"IN"},{"id":"T330","span":{"begin":114,"end":115},"obj":"NN"},{"id":"T331","span":{"begin":116,"end":119},"obj":"CC"},{"id":"T332","span":{"begin":120,"end":127},"obj":"VBZ"},{"id":"T333","span":{"begin":128,"end":130},"obj":"NN"},{"id":"T334","span":{"begin":131,"end":141},"obj":"NN"},{"id":"T335","span":{"begin":142,"end":144},"obj":"IN"},{"id":"T336","span":{"begin":145,"end":151},"obj":"NNS"},{"id":"T337","span":{"begin":152,"end":157},"obj":"VBN"},{"id":"T338","span":{"begin":158,"end":160},"obj":"IN"},{"id":"T339","span":{"begin":161,"end":174},"obj":"JJ"},{"id":"T340","span":{"begin":175,"end":179},"obj":"NNS"},{"id":"T341","span":{"begin":179,"end":180},"obj":"."},{"id":"T342","span":{"begin":180,"end":286},"obj":"sentence"},{"id":"T343","span":{"begin":181,"end":192},"obj":"NN"},{"id":"T344","span":{"begin":243,"end":248},"obj":"VBZ"},{"id":"T345","span":{"begin":193,"end":195},"obj":"IN"},{"id":"T346","span":{"begin":196,"end":206},"obj":"JJ"},{"id":"T347","span":{"begin":210,"end":219},"obj":"NN"},{"id":"T348","span":{"begin":207,"end":209},"obj":"NN"},{"id":"T349","span":{"begin":220,"end":222},"obj":"IN"},{"id":"T350","span":{"begin":223,"end":227},"obj":"DT"},{"id":"T351","span":{"begin":228,"end":233},"obj":"NN"},{"id":"T352","span":{"begin":234,"end":242},"obj":"RB"},{"id":"T353","span":{"begin":249,"end":252},"obj":"DT"},{"id":"T354","span":{"begin":253,"end":264},"obj":"NN"},{"id":"T355","span":{"begin":265,"end":267},"obj":"IN"},{"id":"T356","span":{"begin":268,"end":275},"obj":"NN"},{"id":"T357","span":{"begin":276,"end":285},"obj":"NN"},{"id":"T358","span":{"begin":285,"end":286},"obj":"."},{"id":"T360","span":{"begin":287,"end":294},"obj":"RB"},{"id":"T362","span":{"begin":294,"end":296},"obj":","},{"id":"T363","span":{"begin":296,"end":305},"obj":"NN"},{"id":"T364","span":{"begin":306,"end":309},"obj":"CC"}],"relations":[{"id":"R160","pred":"compound","subj":"T314","obj":"T313"},{"id":"R164","pred":"ccomp","subj":"T320","obj":"T318"},{"id":"R165","pred":"compound","subj":"T321","obj":"T322"},{"id":"R166","pred":"nsubj","subj":"T322","obj":"T320"},{"id":"R168","pred":"dobj","subj":"T324","obj":"T320"},{"id":"R169","pred":"compound","subj":"T325","obj":"T324"},{"id":"R172","pred":"nummod","subj":"T328","obj":"T330"},{"id":"R173","pred":"quantmod","subj":"T329","obj":"T328"},{"id":"R189","pred":"pobj","subj":"T347","obj":"T345"},{"id":"R190","pred":"compound","subj":"T348","obj":"T347"},{"id":"R162","pred":"nsubj","subj":"T317","obj":"T318"},{"id":"R163","pred":"mark","subj":"T319","obj":"T320"},{"id":"R167","pred":"amod","subj":"T323","obj":"T324"},{"id":"R170","pred":"prep","subj":"T326","obj":"T320"},{"id":"R171","pred":"amod","subj":"T327","obj":"T328"},{"id":"R174","pred":"pobj","subj":"T330","obj":"T326"},{"id":"R175","pred":"cc","subj":"T331","obj":"T320"},{"id":"R176","pred":"conj","subj":"T332","obj":"T320"},{"id":"R177","pred":"compound","subj":"T333","obj":"T334"},{"id":"R178","pred":"dobj","subj":"T334","obj":"T332"},{"id":"R179","pred":"prep","subj":"T335","obj":"T332"},{"id":"R180","pred":"pobj","subj":"T336","obj":"T335"},{"id":"R181","pred":"acl","subj":"T337","obj":"T336"},{"id":"R182","pred":"prep","subj":"T338","obj":"T337"},{"id":"R183","pred":"amod","subj":"T339","obj":"T340"},{"id":"R184","pred":"pobj","subj":"T340","obj":"T338"},{"id":"R185","pred":"punct","subj":"T341","obj":"T318"},{"id":"R186","pred":"nsubj","subj":"T343","obj":"T344"},{"id":"R187","pred":"prep","subj":"T345","obj":"T343"},{"id":"R188","pred":"amod","subj":"T346","obj":"T347"},{"id":"R191","pred":"prep","subj":"T349","obj":"T343"},{"id":"R192","pred":"det","subj":"T350","obj":"T351"},{"id":"R193","pred":"pobj","subj":"T351","obj":"T349"},{"id":"R194","pred":"advmod","subj":"T352","obj":"T344"},{"id":"R195","pred":"det","subj":"T353","obj":"T354"},{"id":"R196","pred":"dobj","subj":"T354","obj":"T344"},{"id":"R197","pred":"prep","subj":"T355","obj":"T354"},{"id":"R198","pred":"compound","subj":"T356","obj":"T357"},{"id":"R199","pred":"pobj","subj":"T357","obj":"T355"},{"id":"R200","pred":"punct","subj":"T358","obj":"T344"},{"id":"R204","pred":"cc","subj":"T364","obj":"T363"}],"attributes":[{"subj":"T313","pred":"source","obj":"craft-sa-dev"},{"subj":"T314","pred":"source","obj":"craft-sa-dev"},{"subj":"T315","pred":"source","obj":"craft-sa-dev"},{"subj":"T316","pred":"source","obj":"craft-sa-dev"},{"subj":"T317","pred":"source","obj":"craft-sa-dev"},{"subj":"T318","pred":"source","obj":"craft-sa-dev"},{"subj":"T319","pred":"source","obj":"craft-sa-dev"},{"subj":"T320","pred":"source","obj":"craft-sa-dev"},{"subj":"T321","pred":"source","obj":"craft-sa-dev"},{"subj":"T322","pred":"source","obj":"craft-sa-dev"},{"subj":"T323","pred":"source","obj":"craft-sa-dev"},{"subj":"T324","pred":"source","obj":"craft-sa-dev"},{"subj":"T325","pred":"source","obj":"craft-sa-dev"},{"subj":"T326","pred":"source","obj":"craft-sa-dev"},{"subj":"T327","pred":"source","obj":"craft-sa-dev"},{"subj":"T328","pred":"source","obj":"craft-sa-dev"},{"subj":"T329","pred":"source","obj":"craft-sa-dev"},{"subj":"T330","pred":"source","obj":"craft-sa-dev"},{"subj":"T331","pred":"source","obj":"craft-sa-dev"},{"subj":"T332","pred":"source","obj":"craft-sa-dev"},{"subj":"T333","pred":"source","obj":"craft-sa-dev"},{"subj":"T334","pred":"source","obj":"craft-sa-dev"},{"subj":"T335","pred":"source","obj":"craft-sa-dev"},{"subj":"T336","pred":"source","obj":"craft-sa-dev"},{"subj":"T337","pred":"source","obj":"craft-sa-dev"},{"subj":"T338","pred":"source","obj":"craft-sa-dev"},{"subj":"T339","pred":"source","obj":"craft-sa-dev"},{"subj":"T340","pred":"source","obj":"craft-sa-dev"},{"subj":"T341","pred":"source","obj":"craft-sa-dev"},{"subj":"T342","pred":"source","obj":"craft-sa-dev"},{"subj":"T343","pred":"source","obj":"craft-sa-dev"},{"subj":"T344","pred":"source","obj":"craft-sa-dev"},{"subj":"T345","pred":"source","obj":"craft-sa-dev"},{"subj":"T346","pred":"source","obj":"craft-sa-dev"},{"subj":"T347","pred":"source","obj":"craft-sa-dev"},{"subj":"T348","pred":"source","obj":"craft-sa-dev"},{"subj":"T349","pred":"source","obj":"craft-sa-dev"},{"subj":"T350","pred":"source","obj":"craft-sa-dev"},{"subj":"T351","pred":"source","obj":"craft-sa-dev"},{"subj":"T352","pred":"source","obj":"craft-sa-dev"},{"subj":"T353","pred":"source","obj":"craft-sa-dev"},{"subj":"T354","pred":"source","obj":"craft-sa-dev"},{"subj":"T355","pred":"source","obj":"craft-sa-dev"},{"subj":"T356","pred":"source","obj":"craft-sa-dev"},{"subj":"T357","pred":"source","obj":"craft-sa-dev"},{"subj":"T358","pred":"source","obj":"craft-sa-dev"},{"subj":"T360","pred":"source","obj":"craft-sa-dev"},{"subj":"T362","pred":"source","obj":"craft-sa-dev"},{"subj":"T363","pred":"source","obj":"craft-sa-dev"},{"subj":"T364","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T111","span":{"begin":2,"end":9},"obj":"CHEBI:60425"},{"id":"T112","span":{"begin":34,"end":45},"obj":"CHEBI:50845"},{"id":"T113","span":{"begin":70,"end":80},"obj":"SO_EXT:transgenic_entity"},{"id":"T114","span":{"begin":81,"end":84},"obj":"PR_EXT:000004168"},{"id":"T115","span":{"begin":85,"end":95},"obj":"GO:0010467"},{"id":"T116","span":{"begin":128,"end":130},"obj":"CHEBI_PR_EXT:amyloid_beta"},{"id":"T117","span":{"begin":128,"end":141},"obj":"GO:0034205"},{"id":"T118","span":{"begin":164,"end":174},"obj":"SO_EXT:transgenic_entity"},{"id":"T119","span":{"begin":175,"end":179},"obj":"NCBITaxon:10088"},{"id":"T120","span":{"begin":196,"end":206},"obj":"SO_EXT:transgenic_entity"},{"id":"T121","span":{"begin":207,"end":209},"obj":"CHEBI_PR_EXT:amyloid_beta"},{"id":"T122","span":{"begin":207,"end":219},"obj":"GO:0034205"},{"id":"T123","span":{"begin":268,"end":275},"obj":"CHEBI:60425"}],"attributes":[{"subj":"T111","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T112","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T113","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T114","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T115","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T116","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T117","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T118","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T119","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T120","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T121","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T122","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T123","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T58","span":{"begin":2,"end":9},"obj":"CHEBI:60425"},{"id":"T59","span":{"begin":34,"end":45},"obj":"CHEBI:50845"},{"id":"T60","span":{"begin":81,"end":84},"obj":"PR:000004168"},{"id":"T61","span":{"begin":85,"end":95},"obj":"GO:0010467"},{"id":"T62","span":{"begin":128,"end":141},"obj":"GO:0034205"},{"id":"T63","span":{"begin":175,"end":179},"obj":"NCBITaxon:10088"},{"id":"T64","span":{"begin":207,"end":219},"obj":"GO:0034205"},{"id":"T65","span":{"begin":268,"end":275},"obj":"CHEBI:60425"}],"attributes":[{"subj":"T58","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T59","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T60","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T61","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T62","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T63","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T64","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T65","pred":"source","obj":"craft-ca-core-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#ec93e1","default":true},{"id":"craft-ca-core-ex-dev","color":"#93ecdc"},{"id":"craft-ca-core-dev","color":"#ecc293"}]}]}}