PMC:1271393 / 23744-24885 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1271393","sourcedb":"PMC","sourceid":"1271393","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1271393","text":"Levels of Polymorphism and Divergence between Humans and Chimpanzees\nThe average nucleotide diversity (π) was strikingly different, both between the two genes and among populations (table 2). Globally, π values were three- to fivefold lower for CD209 (3–7×10−4) than for CD209L (∼16 × 10−4), except for African populations, for whom the CD209 π value was unusually high (26×10−4) because of the presence of the highly divergent cluster A. Indeed, when cluster A was excluded from the analysis, the African π value dropped to 8×10−4. To estimate the substitution rate of each region and evince possible mutational differences that could explain the strong contrast observed in nucleotide-diversity patterns, we determined the human-chimpanzee divergence for both genes. The average net number of differences between the two species was 77.3 substitutions (or 0.0157 substitutions per nucleotide) for CD209 and 90.6 substitutions (or 0.0171 substitutions per nucleotide) for CD209L. Since the human-chimpanzee speciation occurred 5 MYA, we obtained similar nucleotide-substitution rates per site per year (CD209, 1.57×10−9; CD209L, 1.70×10−9).","divisions":[{"label":"title","span":{"begin":0,"end":68}}],"tracks":[]}