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of an individual trial\nThe mouse initiates each trial by breaking a light barrier at the opening of the sampling port (see also [3]). This opens one of eight odor valves, and a diversion valve that diverts all air flow away from the animal for typically 500 ms. After the release of the diversion valve, the odor is accessible to the animal for 2,000 ms. If it continuously licks at the lick port during this time (once in at least three out of four 500-ms bins), it can receive a 2- to 4-μl water reward after the end of the 2,000-ms period. If the animal does not continuously lick, or if the presented odor was a designated nonrewarded odor, neither a reward is given nor any sort of punishment, to minimize stress for the animal. Trials are counted as correct if the animal licks continuously upon presentation of a rewarded odor or does not lick continuously with a nonrewarded odor. A second trial cannot be initiated unless an intertrial interval of at least 5 s has passed. This interval is sufficiently long so that animals typically retract quickly after the end of the trial. Odors are presented in a pseudo-randomized scheme (no more than two successive presentations of the same odor, equal numbers within each 20-trial block). No intrinsic preference toward any of the odors was observed but controlled for by counterbalancing.\nA total of 100–300 trials were performed each day, separated into 30- to 40-min stretches to ensure maximal motivation despite the mild water restriction scheme. Additionally, motivation was controlled by monitoring intertrial intervals and the response frequency [3]."}

{"project":"2_test","denotations":[{"id":"16216087-15572116-84723799","span":{"begin":139,"end":140},"obj":"15572116"},{"id":"16216087-15572116-84723800","span":{"begin":1617,"end":1618},"obj":"15572116"},{"id":"T93070","span":{"begin":139,"end":140},"obj":"15572116"},{"id":"T72876","span":{"begin":1617,"end":1618},"obj":"15572116"}],"text":"Structure of an individual trial\nThe mouse initiates each trial by breaking a light barrier at the opening of the sampling port (see also [3]). This opens one of eight odor valves, and a diversion valve that diverts all air flow away from the animal for typically 500 ms. After the release of the diversion valve, the odor is accessible to the animal for 2,000 ms. If it continuously licks at the lick port during this time (once in at least three out of four 500-ms bins), it can receive a 2- to 4-μl water reward after the end of the 2,000-ms period. If the animal does not continuously lick, or if the presented odor was a designated nonrewarded odor, neither a reward is given nor any sort of punishment, to minimize stress for the animal. Trials are counted as correct if the animal licks continuously upon presentation of a rewarded odor or does not lick continuously with a nonrewarded odor. A second trial cannot be initiated unless an intertrial interval of at least 5 s has passed. This interval is sufficiently long so that animals typically retract quickly after the end of the trial. Odors are presented in a pseudo-randomized scheme (no more than two successive presentations of the same odor, equal numbers within each 20-trial block). No intrinsic preference toward any of the odors was observed but controlled for by counterbalancing.\nA total of 100–300 trials were performed each day, separated into 30- to 40-min stretches to ensure maximal motivation despite the mild water restriction scheme. Additionally, motivation was controlled by monitoring intertrial intervals and the response frequency [3]."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T15322","span":{"begin":37,"end":42},"obj":"NCBITaxon:10088"},{"id":"T15323","span":{"begin":243,"end":249},"obj":"NCBITaxon:33208"},{"id":"T15324","span":{"begin":344,"end":350},"obj":"NCBITaxon:33208"},{"id":"T15325","span":{"begin":502,"end":507},"obj":"CHEBI:15377"},{"id":"T15326","span":{"begin":560,"end":566},"obj":"NCBITaxon:33208"},{"id":"T15327","span":{"begin":736,"end":742},"obj":"NCBITaxon:33208"},{"id":"T15328","span":{"begin":781,"end":787},"obj":"NCBITaxon:33208"},{"id":"T15329","span":{"begin":1035,"end":1042},"obj":"NCBITaxon:33208"},{"id":"T15330","span":{"begin":1488,"end":1493},"obj":"CHEBI:15377"},{"id":"T15331","span":{"begin":1597,"end":1605},"obj":"GO_EXT:reaction_or_response"}],"text":"Structure of an individual trial\nThe mouse initiates each trial by breaking a light barrier at the opening of the sampling port (see also [3]). This opens one of eight odor valves, and a diversion valve that diverts all air flow away from the animal for typically 500 ms. After the release of the diversion valve, the odor is accessible to the animal for 2,000 ms. If it continuously licks at the lick port during this time (once in at least three out of four 500-ms bins), it can receive a 2- to 4-μl water reward after the end of the 2,000-ms period. If the animal does not continuously lick, or if the presented odor was a designated nonrewarded odor, neither a reward is given nor any sort of punishment, to minimize stress for the animal. Trials are counted as correct if the animal licks continuously upon presentation of a rewarded odor or does not lick continuously with a nonrewarded odor. A second trial cannot be initiated unless an intertrial interval of at least 5 s has passed. This interval is sufficiently long so that animals typically retract quickly after the end of the trial. Odors are presented in a pseudo-randomized scheme (no more than two successive presentations of the same odor, equal numbers within each 20-trial block). No intrinsic preference toward any of the odors was observed but controlled for by counterbalancing.\nA total of 100–300 trials were performed each day, separated into 30- to 40-min stretches to ensure maximal motivation despite the mild water restriction scheme. Additionally, motivation was controlled by monitoring intertrial intervals and the response frequency [3]."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T15313","span":{"begin":37,"end":42},"obj":"NCBITaxon:10088"},{"id":"T15314","span":{"begin":243,"end":249},"obj":"NCBITaxon:33208"},{"id":"T15315","span":{"begin":344,"end":350},"obj":"NCBITaxon:33208"},{"id":"T15316","span":{"begin":502,"end":507},"obj":"CHEBI:15377"},{"id":"T15317","span":{"begin":560,"end":566},"obj":"NCBITaxon:33208"},{"id":"T15318","span":{"begin":736,"end":742},"obj":"NCBITaxon:33208"},{"id":"T15319","span":{"begin":781,"end":787},"obj":"NCBITaxon:33208"},{"id":"T15320","span":{"begin":1035,"end":1042},"obj":"NCBITaxon:33208"},{"id":"T15321","span":{"begin":1488,"end":1493},"obj":"CHEBI:15377"}],"text":"Structure of an individual trial\nThe mouse initiates each trial by breaking a light barrier at the opening of the sampling port (see also [3]). This opens one of eight odor valves, and a diversion valve that diverts all air flow away from the animal for typically 500 ms. After the release of the diversion valve, the odor is accessible to the animal for 2,000 ms. If it continuously licks at the lick port during this time (once in at least three out of four 500-ms bins), it can receive a 2- to 4-μl water reward after the end of the 2,000-ms period. If the animal does not continuously lick, or if the presented odor was a designated nonrewarded odor, neither a reward is given nor any sort of punishment, to minimize stress for the animal. Trials are counted as correct if the animal licks continuously upon presentation of a rewarded odor or does not lick continuously with a nonrewarded odor. A second trial cannot be initiated unless an intertrial interval of at least 5 s has passed. This interval is sufficiently long so that animals typically retract quickly after the end of the trial. Odors are presented in a pseudo-randomized scheme (no more than two successive presentations of the same odor, equal numbers within each 20-trial block). No intrinsic preference toward any of the odors was observed but controlled for by counterbalancing.\nA total of 100–300 trials were performed each day, separated into 30- to 40-min stretches to ensure maximal motivation despite the mild water restriction scheme. Additionally, motivation was controlled by monitoring intertrial intervals and the response frequency [3]."}