Id |
Subject |
Object |
Predicate |
Lexical cue |
T12562 |
0-2 |
IN |
denotes |
In |
T12563 |
18-26 |
VBD |
denotes |
combined |
T12564 |
3-7 |
DT |
denotes |
this |
T12565 |
8-13 |
NN |
denotes |
study |
T12566 |
13-15 |
, |
denotes |
, |
T12567 |
15-17 |
PRP |
denotes |
we |
T12568 |
27-38 |
RB |
denotes |
genetically |
T12569 |
39-46 |
VBN |
denotes |
induced |
T12570 |
47-59 |
NN |
denotes |
manipulation |
T12571 |
60-62 |
IN |
denotes |
of |
T12572 |
63-66 |
DT |
denotes |
the |
T12573 |
73-84 |
NN |
denotes |
composition |
T12574 |
67-72 |
NN |
denotes |
AMPAR |
T12575 |
85-89 |
IN |
denotes |
with |
T12576 |
90-102 |
JJ |
denotes |
quantitative |
T12577 |
128-136 |
NNS |
denotes |
analyses |
T12578 |
103-113 |
JJ |
denotes |
behavioral |
T12579 |
114-117 |
CC |
denotes |
and |
T12580 |
118-127 |
JJ |
denotes |
molecular |
T12581 |
136-137 |
. |
denotes |
. |
T12582 |
137-375 |
sentence |
denotes |
We could thus provide evidence for opposing roles of specific GluR-B manipulation and increased Ca2+ influx via AMPARs in olfactory discrimination/learning, and memory, potentially in the olfactory bulb and piriform cortex, respectively. |
T12583 |
138-140 |
PRP |
denotes |
We |
T12584 |
152-159 |
VB |
denotes |
provide |
T12585 |
141-146 |
MD |
denotes |
could |
T12586 |
147-151 |
RB |
denotes |
thus |
T12587 |
160-168 |
NN |
denotes |
evidence |
T12588 |
169-172 |
IN |
denotes |
for |
T12589 |
173-181 |
VBG |
denotes |
opposing |
T12590 |
182-187 |
NNS |
denotes |
roles |
T12591 |
188-190 |
IN |
denotes |
of |
T12592 |
191-199 |
JJ |
denotes |
specific |
T12593 |
207-219 |
NN |
denotes |
manipulation |
T12594 |
200-204 |
NN |
denotes |
GluR |
T12595 |
205-206 |
NN |
denotes |
B |
T12596 |
204-205 |
HYPH |
denotes |
- |
T12597 |
220-223 |
CC |
denotes |
and |
T12598 |
224-233 |
VBN |
denotes |
increased |
T12599 |
239-245 |
NN |
denotes |
influx |
T12600 |
234-237 |
NN |
denotes |
Ca2 |
T12601 |
237-238 |
SYM |
denotes |
+ |
T12602 |
246-249 |
IN |
denotes |
via |
T12603 |
250-256 |
NNS |
denotes |
AMPARs |
T12604 |
257-259 |
IN |
denotes |
in |
T12605 |
260-269 |
JJ |
denotes |
olfactory |
T12606 |
285-293 |
NN |
denotes |
learning |
T12607 |
270-284 |
NN |
denotes |
discrimination |
T12608 |
284-285 |
HYPH |
denotes |
/ |
T12609 |
293-295 |
, |
denotes |
, |
T12610 |
295-298 |
CC |
denotes |
and |
T12611 |
299-305 |
NN |
denotes |
memory |
T12612 |
305-307 |
, |
denotes |
, |
T12613 |
307-318 |
RB |
denotes |
potentially |
T12614 |
319-321 |
IN |
denotes |
in |
T12615 |
322-325 |
DT |
denotes |
the |
T12616 |
336-340 |
NN |
denotes |
bulb |
T12617 |
326-335 |
JJ |
denotes |
olfactory |
T12618 |
341-344 |
CC |
denotes |
and |
T12619 |
345-353 |
JJ |
denotes |
piriform |
T12620 |
354-360 |
NN |
denotes |
cortex |
T12621 |
360-362 |
, |
denotes |
, |
T12622 |
362-374 |
RB |
denotes |
respectively |
T12623 |
374-375 |
. |
denotes |
. |
T12624 |
375-687 |
sentence |
denotes |
To achieve this, we made use of the epigenetic variability in the extent of GluR-B ablation, which correlated with the variability in odor memory, but not in discrimination and learning; this finding was subsequently confirmed in GluR-B rescue mice with piriform cortex-specific transgenic expression of GluR-B. |
T12625 |
376-378 |
TO |
denotes |
To |
T12626 |
379-386 |
VB |
denotes |
achieve |
T12627 |
396-400 |
VBD |
denotes |
made |
T12628 |
387-391 |
DT |
denotes |
this |
T12629 |
391-393 |
, |
denotes |
, |
T12630 |
393-395 |
PRP |
denotes |
we |
T12631 |
593-602 |
VBN |
denotes |
confirmed |
T12632 |
401-404 |
NN |
denotes |
use |
T12633 |
405-407 |
IN |
denotes |
of |
T12634 |
408-411 |
DT |
denotes |
the |
T12635 |
423-434 |
NN |
denotes |
variability |
T12636 |
412-422 |
JJ |
denotes |
epigenetic |
T12637 |
435-437 |
IN |
denotes |
in |
T12638 |
438-441 |
DT |
denotes |
the |
T12639 |
442-448 |
NN |
denotes |
extent |
T12640 |
449-451 |
IN |
denotes |
of |
T12641 |
452-456 |
NN |
denotes |
GluR |
T12642 |
457-458 |
NN |
denotes |
B |
T12643 |
456-457 |
HYPH |
denotes |
- |
T12644 |
459-467 |
NN |
denotes |
ablation |
T12645 |
467-469 |
, |
denotes |
, |
T12646 |
469-474 |
WDT |
denotes |
which |
T12647 |
475-485 |
VBD |
denotes |
correlated |
T12648 |
486-490 |
IN |
denotes |
with |
T12649 |
491-494 |
DT |
denotes |
the |
T12650 |
495-506 |
NN |
denotes |
variability |
T12651 |
507-509 |
IN |
denotes |
in |
T12652 |
510-514 |
NN |
denotes |
odor |
T12653 |
515-521 |
NN |
denotes |
memory |
T12654 |
521-523 |
, |
denotes |
, |
T12655 |
523-526 |
CC |
denotes |
but |
T12656 |
527-530 |
RB |
denotes |
not |
T12657 |
531-533 |
IN |
denotes |
in |
T12658 |
534-548 |
NN |
denotes |
discrimination |
T12659 |
549-552 |
CC |
denotes |
and |
T12660 |
553-561 |
NN |
denotes |
learning |
T12661 |
561-562 |
: |
denotes |
; |
T12662 |
563-567 |
DT |
denotes |
this |
T12663 |
568-575 |
NN |
denotes |
finding |
T12664 |
576-579 |
VBD |
denotes |
was |
T12665 |
580-592 |
RB |
denotes |
subsequently |
T12666 |
603-605 |
IN |
denotes |
in |
T12667 |
606-610 |
NN |
denotes |
GluR |
T12668 |
611-612 |
NN |
denotes |
B |
T12669 |
610-611 |
HYPH |
denotes |
- |
T12670 |
620-624 |
NNS |
denotes |
mice |
T12671 |
613-619 |
NN |
denotes |
rescue |
T12672 |
625-629 |
IN |
denotes |
with |
T12673 |
630-638 |
JJ |
denotes |
piriform |
T12674 |
639-645 |
NN |
denotes |
cortex |
T12675 |
646-654 |
JJ |
denotes |
specific |
T12676 |
645-646 |
HYPH |
denotes |
- |
T12677 |
666-676 |
NN |
denotes |
expression |
T12678 |
655-665 |
JJ |
denotes |
transgenic |
T12679 |
677-679 |
IN |
denotes |
of |
T12680 |
680-684 |
NN |
denotes |
GluR |
T12681 |
685-686 |
NN |
denotes |
B |
T12682 |
684-685 |
HYPH |
denotes |
- |
T12683 |
686-687 |
. |
denotes |
. |
T12684 |
687-983 |
sentence |
denotes |
Extending these principles of combining quantitative behavioral analyses with minimal and dosed genetic interference, together with further physiological analyses, will ultimately pinpoint the neural circuitries underlying related, but distinct, behavioral traits in olfactory and other systems. |
T12685 |
688-697 |
VBG |
denotes |
Extending |
T12686 |
868-876 |
VB |
denotes |
pinpoint |
T12687 |
698-703 |
DT |
denotes |
these |
T12688 |
704-714 |
NNS |
denotes |
principles |
T12689 |
715-717 |
IN |
denotes |
of |
T12690 |
718-727 |
VBG |
denotes |
combining |
T12691 |
728-740 |
JJ |
denotes |
quantitative |
T12692 |
752-760 |
NNS |
denotes |
analyses |
T12693 |
741-751 |
JJ |
denotes |
behavioral |
T12694 |
761-765 |
IN |
denotes |
with |
T12695 |
766-773 |
JJ |
denotes |
minimal |
T12696 |
792-804 |
NN |
denotes |
interference |
T12697 |
774-777 |
CC |
denotes |
and |
T12698 |
778-783 |
VBN |
denotes |
dosed |
T12699 |
784-791 |
JJ |
denotes |
genetic |
T12700 |
804-806 |
, |
denotes |
, |
T12701 |
806-814 |
RB |
denotes |
together |
T12702 |
815-819 |
IN |
denotes |
with |
T12703 |
820-827 |
JJ |
denotes |
further |
T12704 |
842-850 |
NNS |
denotes |
analyses |
T12705 |
828-841 |
JJ |
denotes |
physiological |
T12706 |
850-852 |
, |
denotes |
, |
T12707 |
852-856 |
MD |
denotes |
will |
T12708 |
857-867 |
RB |
denotes |
ultimately |
T12709 |
877-880 |
DT |
denotes |
the |
T12710 |
888-899 |
NNS |
denotes |
circuitries |
T12711 |
881-887 |
JJ |
denotes |
neural |
T12712 |
900-910 |
VBG |
denotes |
underlying |
T12713 |
911-918 |
JJ |
denotes |
related |
T12714 |
945-951 |
NNS |
denotes |
traits |
T12715 |
918-920 |
, |
denotes |
, |
T12716 |
920-923 |
CC |
denotes |
but |
T12717 |
924-932 |
JJ |
denotes |
distinct |
T12718 |
932-934 |
, |
denotes |
, |
T12719 |
934-944 |
JJ |
denotes |
behavioral |
T12720 |
952-954 |
IN |
denotes |
in |
T12721 |
955-964 |
JJ |
denotes |
olfactory |
T12722 |
975-982 |
NNS |
denotes |
systems |
T12723 |
965-968 |
CC |
denotes |
and |
T12724 |
969-974 |
JJ |
denotes |
other |
T12725 |
982-983 |
. |
denotes |
. |
R8240 |
T12562 |
T12563 |
prep |
In,combined |
R8241 |
T12564 |
T12565 |
det |
this,study |
R8242 |
T12565 |
T12562 |
pobj |
study,In |
R8243 |
T12566 |
T12563 |
punct |
", ",combined |
R8244 |
T12567 |
T12563 |
nsubj |
we,combined |
R8245 |
T12568 |
T12569 |
advmod |
genetically,induced |
R8246 |
T12569 |
T12570 |
amod |
induced,manipulation |
R8247 |
T12570 |
T12563 |
dobj |
manipulation,combined |
R8248 |
T12571 |
T12570 |
prep |
of,manipulation |
R8249 |
T12572 |
T12573 |
det |
the,composition |
R8250 |
T12573 |
T12571 |
pobj |
composition,of |
R8251 |
T12574 |
T12573 |
compound |
AMPAR,composition |
R8252 |
T12575 |
T12563 |
prep |
with,combined |
R8253 |
T12576 |
T12577 |
amod |
quantitative,analyses |
R8254 |
T12577 |
T12575 |
pobj |
analyses,with |
R8255 |
T12578 |
T12577 |
amod |
behavioral,analyses |
R8256 |
T12579 |
T12578 |
cc |
and,behavioral |
R8257 |
T12580 |
T12578 |
conj |
molecular,behavioral |
R8258 |
T12581 |
T12563 |
punct |
.,combined |
R8259 |
T12583 |
T12584 |
nsubj |
We,provide |
R8260 |
T12585 |
T12584 |
aux |
could,provide |
R8261 |
T12586 |
T12584 |
advmod |
thus,provide |
R8262 |
T12587 |
T12584 |
dobj |
evidence,provide |
R8263 |
T12588 |
T12587 |
prep |
for,evidence |
R8264 |
T12589 |
T12590 |
amod |
opposing,roles |
R8265 |
T12590 |
T12588 |
pobj |
roles,for |
R8266 |
T12591 |
T12590 |
prep |
of,roles |
R8267 |
T12592 |
T12593 |
amod |
specific,manipulation |
R8268 |
T12593 |
T12591 |
pobj |
manipulation,of |
R8269 |
T12594 |
T12595 |
compound |
GluR,B |
R8270 |
T12595 |
T12593 |
compound |
B,manipulation |
R8271 |
T12596 |
T12595 |
punct |
-,B |
R8272 |
T12597 |
T12593 |
cc |
and,manipulation |
R8273 |
T12598 |
T12599 |
amod |
increased,influx |
R8274 |
T12599 |
T12593 |
conj |
influx,manipulation |
R8275 |
T12600 |
T12599 |
nmod |
Ca2,influx |
R8276 |
T12601 |
T12600 |
punct |
+,Ca2 |
R8277 |
T12602 |
T12599 |
prep |
via,influx |
R8278 |
T12603 |
T12602 |
pobj |
AMPARs,via |
R8279 |
T12604 |
T12590 |
prep |
in,roles |
R8280 |
T12605 |
T12606 |
amod |
olfactory,learning |
R8281 |
T12606 |
T12604 |
pobj |
learning,in |
R8282 |
T12607 |
T12606 |
compound |
discrimination,learning |
R8283 |
T12608 |
T12606 |
punct |
/,learning |
R8284 |
T12609 |
T12606 |
punct |
", ",learning |
R8285 |
T12610 |
T12606 |
cc |
and,learning |
R8286 |
T12611 |
T12606 |
conj |
memory,learning |
R8287 |
T12612 |
T12606 |
punct |
", ",learning |
R8288 |
T12613 |
T12614 |
advmod |
potentially,in |
R8289 |
T12614 |
T12606 |
prep |
in,learning |
R8290 |
T12615 |
T12616 |
det |
the,bulb |
R8291 |
T12616 |
T12614 |
pobj |
bulb,in |
R8292 |
T12617 |
T12616 |
amod |
olfactory,bulb |
R8293 |
T12618 |
T12616 |
cc |
and,bulb |
R8294 |
T12619 |
T12620 |
amod |
piriform,cortex |
R8295 |
T12620 |
T12616 |
conj |
cortex,bulb |
R8296 |
T12621 |
T12616 |
punct |
", ",bulb |
R8297 |
T12622 |
T12616 |
advmod |
respectively,bulb |
R8298 |
T12623 |
T12584 |
punct |
.,provide |
R8299 |
T12625 |
T12626 |
aux |
To,achieve |
R8300 |
T12626 |
T12627 |
advcl |
achieve,made |
R8301 |
T12627 |
T12631 |
ccomp |
made,confirmed |
R8302 |
T12628 |
T12626 |
dobj |
this,achieve |
R8303 |
T12629 |
T12627 |
punct |
", ",made |
R8304 |
T12630 |
T12627 |
nsubj |
we,made |
R8305 |
T12632 |
T12627 |
dobj |
use,made |
R8306 |
T12633 |
T12627 |
prep |
of,made |
R8307 |
T12634 |
T12635 |
det |
the,variability |
R8308 |
T12635 |
T12633 |
pobj |
variability,of |
R8309 |
T12636 |
T12635 |
amod |
epigenetic,variability |
R8310 |
T12637 |
T12635 |
prep |
in,variability |
R8311 |
T12638 |
T12639 |
det |
the,extent |
R8312 |
T12639 |
T12637 |
pobj |
extent,in |
R8313 |
T12640 |
T12639 |
prep |
of,extent |
R8314 |
T12641 |
T12642 |
compound |
GluR,B |
R8315 |
T12642 |
T12644 |
compound |
B,ablation |
R8316 |
T12643 |
T12642 |
punct |
-,B |
R8317 |
T12644 |
T12640 |
pobj |
ablation,of |
R8318 |
T12645 |
T12639 |
punct |
", ",extent |
R8319 |
T12646 |
T12647 |
dep |
which,correlated |
R8320 |
T12647 |
T12639 |
relcl |
correlated,extent |
R8321 |
T12648 |
T12647 |
prep |
with,correlated |
R8322 |
T12649 |
T12650 |
det |
the,variability |
R8323 |
T12650 |
T12648 |
pobj |
variability,with |
R8324 |
T12651 |
T12650 |
prep |
in,variability |
R8325 |
T12652 |
T12653 |
compound |
odor,memory |
R8326 |
T12653 |
T12651 |
pobj |
memory,in |
R8327 |
T12654 |
T12651 |
punct |
", ",in |
R8328 |
T12655 |
T12651 |
cc |
but,in |
R8329 |
T12656 |
T12655 |
neg |
not,but |
R8330 |
T12657 |
T12651 |
conj |
in,in |
R8331 |
T12658 |
T12657 |
pobj |
discrimination,in |
R8332 |
T12659 |
T12658 |
cc |
and,discrimination |
R8333 |
T12660 |
T12658 |
conj |
learning,discrimination |
R8334 |
T12661 |
T12631 |
punct |
;,confirmed |
R8335 |
T12662 |
T12663 |
det |
this,finding |
R8336 |
T12663 |
T12631 |
nsubjpass |
finding,confirmed |
R8337 |
T12664 |
T12631 |
auxpass |
was,confirmed |
R8338 |
T12665 |
T12631 |
advmod |
subsequently,confirmed |
R8339 |
T12666 |
T12631 |
prep |
in,confirmed |
R8340 |
T12667 |
T12668 |
compound |
GluR,B |
R8341 |
T12668 |
T12670 |
compound |
B,mice |
R8342 |
T12669 |
T12668 |
punct |
-,B |
R8343 |
T12670 |
T12666 |
pobj |
mice,in |
R8344 |
T12671 |
T12670 |
compound |
rescue,mice |
R8345 |
T12672 |
T12670 |
prep |
with,mice |
R8346 |
T12673 |
T12674 |
amod |
piriform,cortex |
R8347 |
T12674 |
T12675 |
npadvmod |
cortex,specific |
R8348 |
T12675 |
T12677 |
amod |
specific,expression |
R8349 |
T12676 |
T12675 |
punct |
-,specific |
R8350 |
T12677 |
T12672 |
pobj |
expression,with |
R8351 |
T12678 |
T12677 |
amod |
transgenic,expression |
R8352 |
T12679 |
T12677 |
prep |
of,expression |
R8353 |
T12680 |
T12681 |
compound |
GluR,B |
R8354 |
T12681 |
T12679 |
pobj |
B,of |
R8355 |
T12682 |
T12681 |
punct |
-,B |
R8356 |
T12683 |
T12631 |
punct |
.,confirmed |
R8357 |
T12685 |
T12686 |
csubj |
Extending,pinpoint |
R8358 |
T12687 |
T12688 |
det |
these,principles |
R8359 |
T12688 |
T12685 |
dobj |
principles,Extending |
R8360 |
T12689 |
T12688 |
prep |
of,principles |
R8361 |
T12690 |
T12689 |
pcomp |
combining,of |
R8362 |
T12691 |
T12692 |
amod |
quantitative,analyses |
R8363 |
T12692 |
T12690 |
dobj |
analyses,combining |
R8364 |
T12693 |
T12692 |
amod |
behavioral,analyses |
R8365 |
T12694 |
T12690 |
prep |
with,combining |
R8366 |
T12695 |
T12696 |
amod |
minimal,interference |
R8367 |
T12696 |
T12694 |
pobj |
interference,with |
R8368 |
T12697 |
T12695 |
cc |
and,minimal |
R8369 |
T12698 |
T12695 |
conj |
dosed,minimal |
R8370 |
T12699 |
T12696 |
amod |
genetic,interference |
R8371 |
T12700 |
T12696 |
punct |
", ",interference |
R8372 |
T12701 |
T12696 |
advmod |
together,interference |
R8373 |
T12702 |
T12701 |
prep |
with,together |
R8374 |
T12703 |
T12704 |
amod |
further,analyses |
R8375 |
T12704 |
T12702 |
pobj |
analyses,with |
R8376 |
T12705 |
T12704 |
amod |
physiological,analyses |
R8377 |
T12706 |
T12686 |
punct |
", ",pinpoint |
R8378 |
T12707 |
T12686 |
aux |
will,pinpoint |
R8379 |
T12708 |
T12686 |
advmod |
ultimately,pinpoint |
R8380 |
T12709 |
T12710 |
det |
the,circuitries |
R8381 |
T12710 |
T12686 |
dobj |
circuitries,pinpoint |
R8382 |
T12711 |
T12710 |
amod |
neural,circuitries |
R8383 |
T12712 |
T12710 |
acl |
underlying,circuitries |
R8384 |
T12713 |
T12714 |
amod |
related,traits |
R8385 |
T12714 |
T12712 |
dobj |
traits,underlying |
R8386 |
T12715 |
T12713 |
punct |
", ",related |
R8387 |
T12716 |
T12713 |
cc |
but,related |
R8388 |
T12717 |
T12713 |
conj |
distinct,related |
R8389 |
T12718 |
T12714 |
punct |
", ",traits |
R8390 |
T12719 |
T12714 |
amod |
behavioral,traits |
R8391 |
T12720 |
T12712 |
prep |
in,underlying |
R8392 |
T12721 |
T12722 |
amod |
olfactory,systems |
R8393 |
T12722 |
T12720 |
pobj |
systems,in |
R8394 |
T12723 |
T12721 |
cc |
and,olfactory |
R8395 |
T12724 |
T12721 |
conj |
other,olfactory |
R8396 |
T12725 |
T12686 |
punct |
.,pinpoint |