Id |
Subject |
Object |
Predicate |
Lexical cue |
T72 |
0-8 |
VBN |
denotes |
Enhanced |
T73 |
14-28 |
NN |
denotes |
Discrimination |
T74 |
0-107 |
sentence |
denotes |
Enhanced Odor Discrimination and Impaired Olfactory Memory by Spatially Controlled Switch of AMPA Receptors |
T75 |
9-13 |
NN |
denotes |
Odor |
T76 |
29-32 |
CC |
denotes |
and |
T77 |
33-41 |
VBN |
denotes |
Impaired |
T78 |
52-58 |
NN |
denotes |
Memory |
T79 |
42-51 |
JJ |
denotes |
Olfactory |
T80 |
59-61 |
IN |
denotes |
by |
T81 |
62-71 |
RB |
denotes |
Spatially |
T82 |
72-82 |
VBN |
denotes |
Controlled |
T83 |
83-89 |
NN |
denotes |
Switch |
T84 |
90-92 |
IN |
denotes |
of |
T85 |
93-97 |
NN |
denotes |
AMPA |
T86 |
98-107 |
NNS |
denotes |
Receptors |
T87 |
107-108 |
sentence |
denotes |
|
T88 |
161-342 |
sentence |
denotes |
Genetic perturbations of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. |
T89 |
161-168 |
JJ |
denotes |
Genetic |
T90 |
169-182 |
NNS |
denotes |
perturbations |
T91 |
265-269 |
VBN |
denotes |
used |
T92 |
183-185 |
IN |
denotes |
of |
T93 |
186-187 |
NN |
denotes |
α |
T94 |
188-193 |
NN |
denotes |
amino |
T95 |
187-188 |
HYPH |
denotes |
- |
T96 |
215-234 |
NN |
denotes |
isoxazolepropionate |
T97 |
193-194 |
HYPH |
denotes |
- |
T98 |
194-195 |
CD |
denotes |
3 |
T99 |
196-203 |
NN |
denotes |
hydroxy |
T100 |
195-196 |
HYPH |
denotes |
- |
T101 |
203-204 |
HYPH |
denotes |
- |
T102 |
204-205 |
CD |
denotes |
5 |
T103 |
206-212 |
NN |
denotes |
methyl |
T104 |
205-206 |
HYPH |
denotes |
- |
T105 |
212-213 |
HYPH |
denotes |
- |
T106 |
213-214 |
CD |
denotes |
4 |
T107 |
214-215 |
HYPH |
denotes |
- |
T108 |
235-244 |
NNS |
denotes |
receptors |
T109 |
245-246 |
-LRB- |
denotes |
( |
T110 |
246-252 |
NNS |
denotes |
AMPARs |
T111 |
252-253 |
-RRB- |
denotes |
) |
T112 |
254-257 |
VBP |
denotes |
are |
T113 |
258-264 |
RB |
denotes |
widely |
T114 |
270-272 |
TO |
denotes |
to |
T115 |
273-280 |
VB |
denotes |
dissect |
T116 |
281-290 |
JJ |
denotes |
molecular |
T117 |
291-301 |
NNS |
denotes |
mechanisms |
T118 |
302-304 |
IN |
denotes |
of |
T119 |
305-312 |
JJ |
denotes |
sensory |
T120 |
313-319 |
NN |
denotes |
coding |
T121 |
319-321 |
, |
denotes |
, |
T122 |
321-329 |
NN |
denotes |
learning |
T123 |
329-331 |
, |
denotes |
, |
T124 |
331-334 |
CC |
denotes |
and |
T125 |
335-341 |
NN |
denotes |
memory |
T126 |
341-342 |
. |
denotes |
. |
T127 |
342-430 |
sentence |
denotes |
In this study, we investigated the role of Ca2+-permeable AMPARs in olfactory behavior. |
T128 |
343-345 |
IN |
denotes |
In |
T129 |
361-373 |
VBD |
denotes |
investigated |
T130 |
346-350 |
DT |
denotes |
this |
T131 |
351-356 |
NN |
denotes |
study |
T132 |
356-358 |
, |
denotes |
, |
T133 |
358-360 |
PRP |
denotes |
we |
T134 |
374-377 |
DT |
denotes |
the |
T135 |
378-382 |
NN |
denotes |
role |
T136 |
383-385 |
IN |
denotes |
of |
T137 |
386-389 |
NN |
denotes |
Ca2 |
T138 |
391-400 |
JJ |
denotes |
permeable |
T139 |
389-390 |
SYM |
denotes |
+ |
T140 |
390-391 |
HYPH |
denotes |
- |
T141 |
401-407 |
NNS |
denotes |
AMPARs |
T142 |
408-410 |
IN |
denotes |
in |
T143 |
411-420 |
JJ |
denotes |
olfactory |
T144 |
421-429 |
NN |
denotes |
behavior |
T145 |
429-430 |
. |
denotes |
. |
T146 |
430-589 |
sentence |
denotes |
AMPAR modification was obtained by depletion of the GluR-B subunit or expression of unedited GluR-B(Q), both leading to increased Ca2+ permeability of AMPARs. |
T147 |
431-436 |
NN |
denotes |
AMPAR |
T148 |
437-449 |
NN |
denotes |
modification |
T149 |
454-462 |
VBN |
denotes |
obtained |
T150 |
450-453 |
VBD |
denotes |
was |
T151 |
463-465 |
IN |
denotes |
by |
T152 |
466-475 |
NN |
denotes |
depletion |
T153 |
476-478 |
IN |
denotes |
of |
T154 |
479-482 |
DT |
denotes |
the |
T155 |
490-497 |
NN |
denotes |
subunit |
T156 |
483-487 |
NN |
denotes |
GluR |
T157 |
488-489 |
NN |
denotes |
B |
T158 |
487-488 |
HYPH |
denotes |
- |
T159 |
498-500 |
CC |
denotes |
or |
T160 |
501-511 |
NN |
denotes |
expression |
T161 |
512-514 |
IN |
denotes |
of |
T162 |
515-523 |
JJ |
denotes |
unedited |
T163 |
531-532 |
NN |
denotes |
Q |
T164 |
524-528 |
NN |
denotes |
GluR |
T165 |
528-529 |
HYPH |
denotes |
- |
T166 |
529-530 |
NN |
denotes |
B |
T167 |
530-531 |
-LRB- |
denotes |
( |
T168 |
532-533 |
-RRB- |
denotes |
) |
T169 |
533-535 |
, |
denotes |
, |
T170 |
535-539 |
DT |
denotes |
both |
T171 |
540-547 |
VBG |
denotes |
leading |
T172 |
548-550 |
IN |
denotes |
to |
T173 |
551-560 |
VBN |
denotes |
increased |
T174 |
566-578 |
NN |
denotes |
permeability |
T175 |
561-564 |
NN |
denotes |
Ca2 |
T176 |
564-565 |
SYM |
denotes |
+ |
T177 |
579-581 |
IN |
denotes |
of |
T178 |
582-588 |
NNS |
denotes |
AMPARs |
T179 |
588-589 |
. |
denotes |
. |
T180 |
589-762 |
sentence |
denotes |
Mice with this functional AMPAR switch, specifically in forebrain, showed enhanced olfactory discrimination and more rapid learning in a go/no-go operant conditioning task. |
T181 |
590-594 |
NNS |
denotes |
Mice |
T182 |
657-663 |
VBD |
denotes |
showed |
T183 |
595-599 |
IN |
denotes |
with |
T184 |
600-604 |
DT |
denotes |
this |
T185 |
622-628 |
NN |
denotes |
switch |
T186 |
605-615 |
JJ |
denotes |
functional |
T187 |
616-621 |
NN |
denotes |
AMPAR |
T188 |
628-630 |
, |
denotes |
, |
T189 |
630-642 |
RB |
denotes |
specifically |
T190 |
643-645 |
IN |
denotes |
in |
T191 |
646-655 |
NN |
denotes |
forebrain |
T192 |
655-657 |
, |
denotes |
, |
T193 |
664-672 |
VBN |
denotes |
enhanced |
T194 |
683-697 |
NN |
denotes |
discrimination |
T195 |
673-682 |
JJ |
denotes |
olfactory |
T196 |
698-701 |
CC |
denotes |
and |
T197 |
702-706 |
RBR |
denotes |
more |
T198 |
707-712 |
JJ |
denotes |
rapid |
T199 |
713-721 |
NN |
denotes |
learning |
T200 |
722-724 |
IN |
denotes |
in |
T201 |
725-726 |
DT |
denotes |
a |
T202 |
757-761 |
NN |
denotes |
task |
T203 |
727-729 |
NN |
denotes |
go |
T204 |
729-730 |
HYPH |
denotes |
/ |
T205 |
730-732 |
DT |
denotes |
no |
T206 |
733-735 |
NN |
denotes |
go |
T207 |
732-733 |
HYPH |
denotes |
- |
T208 |
736-743 |
NN |
denotes |
operant |
T209 |
744-756 |
VBG |
denotes |
conditioning |
T210 |
761-762 |
. |
denotes |
. |
T211 |
762-816 |
sentence |
denotes |
Olfactory memory, however, was dramatically impaired. |
T212 |
763-772 |
JJ |
denotes |
Olfactory |
T213 |
773-779 |
NN |
denotes |
memory |
T214 |
807-815 |
VBN |
denotes |
impaired |
T215 |
779-781 |
, |
denotes |
, |
T216 |
781-788 |
RB |
denotes |
however |
T217 |
788-790 |
, |
denotes |
, |
T218 |
790-793 |
VBD |
denotes |
was |
T219 |
794-806 |
RB |
denotes |
dramatically |
T220 |
815-816 |
. |
denotes |
. |
T221 |
816-983 |
sentence |
denotes |
GluR-B depletion in forebrain was ectopically variable (“mosaic”) among individuals and strongly correlated with decreased olfactory memory in hippocampus and cortex. |
T222 |
817-821 |
NN |
denotes |
GluR |
T223 |
822-823 |
NN |
denotes |
B |
T224 |
821-822 |
HYPH |
denotes |
- |
T225 |
824-833 |
NN |
denotes |
depletion |
T226 |
847-850 |
VBD |
denotes |
was |
T227 |
834-836 |
IN |
denotes |
in |
T228 |
837-846 |
NN |
denotes |
forebrain |
T229 |
851-862 |
RB |
denotes |
ectopically |
T230 |
863-871 |
JJ |
denotes |
variable |
T231 |
872-873 |
-LRB- |
denotes |
( |
T232 |
874-880 |
NN |
denotes |
mosaic |
T233 |
873-874 |
`` |
denotes |
“ |
T234 |
880-881 |
'' |
denotes |
” |
T235 |
881-882 |
-RRB- |
denotes |
) |
T236 |
883-888 |
IN |
denotes |
among |
T237 |
889-900 |
NNS |
denotes |
individuals |
T238 |
901-904 |
CC |
denotes |
and |
T239 |
905-913 |
RB |
denotes |
strongly |
T240 |
914-924 |
VBD |
denotes |
correlated |
T241 |
925-929 |
IN |
denotes |
with |
T242 |
930-939 |
VBN |
denotes |
decreased |
T243 |
950-956 |
NN |
denotes |
memory |
T244 |
940-949 |
JJ |
denotes |
olfactory |
T245 |
957-959 |
IN |
denotes |
in |
T246 |
960-971 |
NN |
denotes |
hippocampus |
T247 |
972-975 |
CC |
denotes |
and |
T248 |
976-982 |
NN |
denotes |
cortex |
T249 |
982-983 |
. |
denotes |
. |
T250 |
983-1206 |
sentence |
denotes |
Accordingly, memory was rescued by transgenic GluR-B expression restricted to piriform cortex and hippocampus, while enhanced odor discrimination was independent of both GluR-B variability and transgenic GluR-B expression. |
T251 |
984-995 |
RB |
denotes |
Accordingly |
T252 |
1008-1015 |
VBN |
denotes |
rescued |
T253 |
995-997 |
, |
denotes |
, |
T254 |
997-1003 |
NN |
denotes |
memory |
T255 |
1004-1007 |
VBD |
denotes |
was |
T256 |
1016-1018 |
IN |
denotes |
by |
T257 |
1019-1029 |
JJ |
denotes |
transgenic |
T258 |
1037-1047 |
NN |
denotes |
expression |
T259 |
1030-1034 |
NN |
denotes |
GluR |
T260 |
1035-1036 |
NN |
denotes |
B |
T261 |
1034-1035 |
HYPH |
denotes |
- |
T262 |
1048-1058 |
VBN |
denotes |
restricted |
T263 |
1059-1061 |
IN |
denotes |
to |
T264 |
1062-1070 |
JJ |
denotes |
piriform |
T265 |
1071-1077 |
NN |
denotes |
cortex |
T266 |
1078-1081 |
CC |
denotes |
and |
T267 |
1082-1093 |
NN |
denotes |
hippocampus |
T268 |
1093-1095 |
, |
denotes |
, |
T269 |
1095-1100 |
IN |
denotes |
while |
T270 |
1130-1133 |
VBD |
denotes |
was |
T271 |
1101-1109 |
VBN |
denotes |
enhanced |
T272 |
1115-1129 |
NN |
denotes |
discrimination |
T273 |
1110-1114 |
NN |
denotes |
odor |
T274 |
1134-1145 |
JJ |
denotes |
independent |
T275 |
1146-1148 |
IN |
denotes |
of |
T276 |
1149-1153 |
CC |
denotes |
both |
T277 |
1161-1172 |
NN |
denotes |
variability |
T278 |
1154-1158 |
NN |
denotes |
GluR |
T279 |
1159-1160 |
NN |
denotes |
B |
T280 |
1158-1159 |
HYPH |
denotes |
- |
T281 |
1173-1176 |
CC |
denotes |
and |
T282 |
1177-1187 |
JJ |
denotes |
transgenic |
T283 |
1195-1205 |
NN |
denotes |
expression |
T284 |
1188-1192 |
NN |
denotes |
GluR |
T285 |
1193-1194 |
NN |
denotes |
B |
T286 |
1192-1193 |
HYPH |
denotes |
- |
T287 |
1205-1206 |
. |
denotes |
. |
T288 |
1206-1388 |
sentence |
denotes |
Thus, correlated differences in behavior and levels of GluR-B expression allowed a mechanistic and spatial dissection of olfactory learning, discrimination, and memory capabilities. |
T289 |
1207-1211 |
RB |
denotes |
Thus |
T290 |
1280-1287 |
VBD |
denotes |
allowed |
T291 |
1211-1213 |
, |
denotes |
, |
T292 |
1213-1223 |
VBN |
denotes |
correlated |
T293 |
1224-1235 |
NNS |
denotes |
differences |
T294 |
1236-1238 |
IN |
denotes |
in |
T295 |
1239-1247 |
NN |
denotes |
behavior |
T296 |
1248-1251 |
CC |
denotes |
and |
T297 |
1252-1258 |
NNS |
denotes |
levels |
T298 |
1259-1261 |
IN |
denotes |
of |
T299 |
1262-1266 |
NN |
denotes |
GluR |
T300 |
1267-1268 |
NN |
denotes |
B |
T301 |
1266-1267 |
HYPH |
denotes |
- |
T302 |
1269-1279 |
NN |
denotes |
expression |
T303 |
1288-1289 |
DT |
denotes |
a |
T304 |
1314-1324 |
NN |
denotes |
dissection |
T305 |
1290-1301 |
JJ |
denotes |
mechanistic |
T306 |
1302-1305 |
CC |
denotes |
and |
T307 |
1306-1313 |
JJ |
denotes |
spatial |
T308 |
1325-1327 |
IN |
denotes |
of |
T309 |
1328-1337 |
JJ |
denotes |
olfactory |
T310 |
1338-1346 |
NN |
denotes |
learning |
T311 |
1375-1387 |
NNS |
denotes |
capabilities |
T312 |
1346-1348 |
, |
denotes |
, |
T313 |
1348-1362 |
NN |
denotes |
discrimination |
T314 |
1362-1364 |
, |
denotes |
, |
T315 |
1364-1367 |
CC |
denotes |
and |
T316 |
1368-1374 |
NN |
denotes |
memory |
T317 |
1387-1388 |
. |
denotes |
. |
T2403 |
7856-7860 |
NN |
denotes |
GluR |
T2404 |
7861-7862 |
NN |
denotes |
B |
T2405 |
7860-7861 |
HYPH |
denotes |
- |
T2406 |
7866-7876 |
NN |
denotes |
Expression |
T2407 |
7862-7863 |
-LRB- |
denotes |
( |
T2408 |
7863-7864 |
NN |
denotes |
Q |
T2409 |
7864-7865 |
-RRB- |
denotes |
) |
T2410 |
7894-7903 |
VBZ |
denotes |
Increases |
T2411 |
7877-7879 |
IN |
denotes |
in |
T2412 |
7880-7883 |
DT |
denotes |
the |
T2413 |
7884-7893 |
NN |
denotes |
Forebrain |
T2414 |
7904-7913 |
JJ |
denotes |
Olfactory |
T2415 |
7914-7922 |
NN |
denotes |
Learning |
T2416 |
7923-7926 |
CC |
denotes |
and |
T2417 |
7927-7941 |
NN |
denotes |
Discrimination |
T2418 |
7941-8211 |
sentence |
denotes |
To explore the role of fast excitatory neurotransmission carried by GluR-B-containing AMPA channels in olfactory processes, we first analyzed mice that express part of the GluR-B population in a Q/R site-unedited form (Figure 1A; termed “GluR-BΔECS:FB”; see also [58]). |
T2419 |
7942-7944 |
TO |
denotes |
To |
T2420 |
7945-7952 |
VB |
denotes |
explore |
T2421 |
8075-8083 |
VBD |
denotes |
analyzed |
T2422 |
7953-7956 |
DT |
denotes |
the |
T2423 |
7957-7961 |
NN |
denotes |
role |
T2424 |
7962-7964 |
IN |
denotes |
of |
T2425 |
7965-7969 |
JJ |
denotes |
fast |
T2426 |
7981-7998 |
NN |
denotes |
neurotransmission |
T2427 |
7970-7980 |
JJ |
denotes |
excitatory |
T2428 |
7999-8006 |
VBN |
denotes |
carried |
T2429 |
8007-8009 |
IN |
denotes |
by |
T2430 |
8010-8014 |
NN |
denotes |
GluR |
T2431 |
8015-8016 |
NN |
denotes |
B |
T2432 |
8014-8015 |
HYPH |
denotes |
- |
T2433 |
8017-8027 |
VBG |
denotes |
containing |
T2434 |
8016-8017 |
HYPH |
denotes |
- |
T2435 |
8033-8041 |
NNS |
denotes |
channels |
T2436 |
8028-8032 |
NN |
denotes |
AMPA |
T2437 |
8042-8044 |
IN |
denotes |
in |
T2438 |
8045-8054 |
JJ |
denotes |
olfactory |
T2439 |
8055-8064 |
NNS |
denotes |
processes |
T2440 |
8064-8066 |
, |
denotes |
, |
T2441 |
8066-8068 |
PRP |
denotes |
we |
T2442 |
8069-8074 |
RB |
denotes |
first |
T2443 |
8084-8088 |
NNS |
denotes |
mice |
T2444 |
8089-8093 |
WDT |
denotes |
that |
T2445 |
8094-8101 |
VBP |
denotes |
express |
T2446 |
8102-8106 |
NN |
denotes |
part |
T2447 |
8107-8109 |
IN |
denotes |
of |
T2448 |
8110-8113 |
DT |
denotes |
the |
T2449 |
8121-8131 |
NN |
denotes |
population |
T2450 |
8114-8118 |
NN |
denotes |
GluR |
T2451 |
8119-8120 |
NN |
denotes |
B |
T2452 |
8118-8119 |
HYPH |
denotes |
- |
T2453 |
8132-8134 |
IN |
denotes |
in |
T2454 |
8135-8136 |
DT |
denotes |
a |
T2455 |
8155-8159 |
NN |
denotes |
form |
T2456 |
8137-8138 |
NN |
denotes |
Q |
T2457 |
8139-8140 |
NN |
denotes |
R |
T2458 |
8138-8139 |
HYPH |
denotes |
/ |
T2459 |
8141-8145 |
NN |
denotes |
site |
T2460 |
8146-8154 |
JJ |
denotes |
unedited |
T2461 |
8145-8146 |
HYPH |
denotes |
- |
T2462 |
8160-8161 |
-LRB- |
denotes |
( |
T2463 |
8168-8170 |
NN |
denotes |
1A |
T2464 |
8161-8167 |
NN |
denotes |
Figure |
T2465 |
8170-8171 |
: |
denotes |
; |
T2466 |
8172-8178 |
VBN |
denotes |
termed |
T2467 |
8179-8180 |
`` |
denotes |
“ |
T2468 |
8180-8184 |
NN |
denotes |
GluR |
T2469 |
8185-8190 |
NN |
denotes |
BΔECS |
T2470 |
8184-8185 |
HYPH |
denotes |
- |
T2471 |
8190-8191 |
: |
denotes |
: |
T2472 |
8191-8193 |
NN |
denotes |
FB |
T2473 |
8193-8194 |
'' |
denotes |
” |
T2474 |
8194-8195 |
: |
denotes |
; |
T2475 |
8196-8199 |
VB |
denotes |
see |
T2476 |
8200-8204 |
RB |
denotes |
also |
T2477 |
8205-8206 |
-LRB- |
denotes |
[ |
T2478 |
8206-8208 |
CD |
denotes |
58 |
T2479 |
8208-8209 |
-RRB- |
denotes |
] |
T2480 |
8209-8210 |
-RRB- |
denotes |
) |
T2481 |
8210-8211 |
. |
denotes |
. |
T2482 |
8211-8546 |
sentence |
denotes |
These mice carry, in addition to a wild-type GluR-B allele, a gene-targeted GluR-Bneo allele in which the intronic sequence critical for GluR-B pre-mRNA editing at the Q/R site is replaced by a floxed TK-neo gene, which severely reduces splicing of the modified intron and hence attenuates the expression of the GluR-Bneo allele [60]. |
T2483 |
8212-8217 |
DT |
denotes |
These |
T2484 |
8218-8222 |
NNS |
denotes |
mice |
T2485 |
8223-8228 |
VBP |
denotes |
carry |
T2486 |
8228-8230 |
, |
denotes |
, |
T2487 |
8230-8232 |
IN |
denotes |
in |
T2488 |
8233-8241 |
NN |
denotes |
addition |
T2489 |
8242-8244 |
IN |
denotes |
to |
T2490 |
8245-8246 |
DT |
denotes |
a |
T2491 |
8264-8270 |
NN |
denotes |
allele |
T2492 |
8247-8251 |
JJ |
denotes |
wild |
T2493 |
8252-8256 |
NN |
denotes |
type |
T2494 |
8251-8252 |
HYPH |
denotes |
- |
T2495 |
8257-8261 |
NN |
denotes |
GluR |
T2496 |
8262-8263 |
NN |
denotes |
B |
T2497 |
8261-8262 |
HYPH |
denotes |
- |
T2498 |
8270-8272 |
, |
denotes |
, |
T2499 |
8272-8273 |
DT |
denotes |
a |
T2500 |
8298-8304 |
NN |
denotes |
allele |
T2501 |
8274-8278 |
NN |
denotes |
gene |
T2502 |
8279-8287 |
VBN |
denotes |
targeted |
T2503 |
8278-8279 |
HYPH |
denotes |
- |
T2504 |
8288-8292 |
NN |
denotes |
GluR |
T2505 |
8293-8297 |
NN |
denotes |
Bneo |
T2506 |
8292-8293 |
HYPH |
denotes |
- |
T2507 |
8305-8307 |
IN |
denotes |
in |
T2508 |
8392-8400 |
VBN |
denotes |
replaced |
T2509 |
8308-8313 |
WDT |
denotes |
which |
T2510 |
8314-8317 |
DT |
denotes |
the |
T2511 |
8327-8335 |
NN |
denotes |
sequence |
T2512 |
8318-8326 |
JJ |
denotes |
intronic |
T2513 |
8336-8344 |
JJ |
denotes |
critical |
T2514 |
8345-8348 |
IN |
denotes |
for |
T2515 |
8349-8353 |
NN |
denotes |
GluR |
T2516 |
8354-8355 |
NN |
denotes |
B |
T2517 |
8353-8354 |
HYPH |
denotes |
- |
T2518 |
8365-8372 |
NN |
denotes |
editing |
T2519 |
8356-8364 |
NN |
denotes |
pre-mRNA |
T2520 |
8373-8375 |
IN |
denotes |
at |
T2521 |
8376-8379 |
DT |
denotes |
the |
T2522 |
8384-8388 |
NN |
denotes |
site |
T2523 |
8380-8381 |
NN |
denotes |
Q |
T2524 |
8382-8383 |
NN |
denotes |
R |
T2525 |
8381-8382 |
HYPH |
denotes |
/ |
T2526 |
8389-8391 |
VBZ |
denotes |
is |
T2527 |
8401-8403 |
IN |
denotes |
by |
T2528 |
8404-8405 |
DT |
denotes |
a |
T2529 |
8420-8424 |
NN |
denotes |
gene |
T2530 |
8406-8412 |
VBN |
denotes |
floxed |
T2531 |
8413-8415 |
NN |
denotes |
TK |
T2532 |
8416-8419 |
NN |
denotes |
neo |
T2533 |
8415-8416 |
HYPH |
denotes |
- |
T2534 |
8424-8426 |
, |
denotes |
, |
T2535 |
8426-8431 |
WDT |
denotes |
which |
T2536 |
8441-8448 |
VBZ |
denotes |
reduces |
T2537 |
8432-8440 |
RB |
denotes |
severely |
T2538 |
8449-8457 |
NN |
denotes |
splicing |
T2539 |
8458-8460 |
IN |
denotes |
of |
T2540 |
8461-8464 |
DT |
denotes |
the |
T2541 |
8474-8480 |
NN |
denotes |
intron |
T2542 |
8465-8473 |
VBN |
denotes |
modified |
T2543 |
8481-8484 |
CC |
denotes |
and |
T2544 |
8485-8490 |
RB |
denotes |
hence |
T2545 |
8491-8501 |
VBZ |
denotes |
attenuates |
T2546 |
8502-8505 |
DT |
denotes |
the |
T2547 |
8506-8516 |
NN |
denotes |
expression |
T2548 |
8517-8519 |
IN |
denotes |
of |
T2549 |
8520-8523 |
DT |
denotes |
the |
T2550 |
8534-8540 |
NN |
denotes |
allele |
T2551 |
8524-8528 |
NN |
denotes |
GluR |
T2552 |
8529-8533 |
NN |
denotes |
Bneo |
T2553 |
8528-8529 |
HYPH |
denotes |
- |
T2554 |
8541-8542 |
-LRB- |
denotes |
[ |
T2555 |
8542-8544 |
CD |
denotes |
60 |
T2556 |
8544-8545 |
-RRB- |
denotes |
] |
T2557 |
8545-8546 |
. |
denotes |
. |
T2558 |
8546-8757 |
sentence |
denotes |
To unsilence the attenuated GluR-Bneo allele, specifically in the postnatal forebrain, we crossed in the TgCre4 transgene, which encodes Cre-recombinase and is driven by the αCaMKII promoter ([59]; “Camkcre4”). |
T2559 |
8547-8549 |
TO |
denotes |
To |
T2560 |
8550-8559 |
VB |
denotes |
unsilence |
T2561 |
8637-8644 |
VBD |
denotes |
crossed |
T2562 |
8560-8563 |
DT |
denotes |
the |
T2563 |
8585-8591 |
NN |
denotes |
allele |
T2564 |
8564-8574 |
VBN |
denotes |
attenuated |
T2565 |
8575-8579 |
NN |
denotes |
GluR |
T2566 |
8580-8584 |
NN |
denotes |
Bneo |
T2567 |
8579-8580 |
HYPH |
denotes |
- |
T2568 |
8591-8593 |
, |
denotes |
, |
T2569 |
8593-8605 |
RB |
denotes |
specifically |
T2570 |
8606-8608 |
IN |
denotes |
in |
T2571 |
8609-8612 |
DT |
denotes |
the |
T2572 |
8623-8632 |
NN |
denotes |
forebrain |
T2573 |
8613-8622 |
JJ |
denotes |
postnatal |
T2574 |
8632-8634 |
, |
denotes |
, |
T2575 |
8634-8636 |
PRP |
denotes |
we |
T2576 |
8645-8647 |
IN |
denotes |
in |
T2577 |
8648-8651 |
DT |
denotes |
the |
T2578 |
8659-8668 |
NN |
denotes |
transgene |
T2579 |
8652-8658 |
NN |
denotes |
TgCre4 |
T2580 |
8668-8670 |
, |
denotes |
, |
T2581 |
8670-8675 |
WDT |
denotes |
which |
T2582 |
8676-8683 |
VBZ |
denotes |
encodes |
T2583 |
8684-8687 |
NN |
denotes |
Cre |
T2584 |
8688-8699 |
NN |
denotes |
recombinase |
T2585 |
8687-8688 |
HYPH |
denotes |
- |
T2586 |
8700-8703 |
CC |
denotes |
and |
T2587 |
8704-8706 |
VBZ |
denotes |
is |
T2588 |
8707-8713 |
VBN |
denotes |
driven |
T2589 |
8714-8716 |
IN |
denotes |
by |
T2590 |
8717-8720 |
DT |
denotes |
the |
T2591 |
8729-8737 |
NN |
denotes |
promoter |
T2592 |
8721-8728 |
NN |
denotes |
αCaMKII |
T2593 |
8738-8739 |
-LRB- |
denotes |
( |
T2594 |
8746-8754 |
NN |
denotes |
Camkcre4 |
T2595 |
8739-8740 |
-LRB- |
denotes |
[ |
T2596 |
8740-8742 |
CD |
denotes |
59 |
T2597 |
8742-8743 |
-RRB- |
denotes |
] |
T2598 |
8743-8744 |
: |
denotes |
; |
T2599 |
8745-8746 |
`` |
denotes |
“ |
T2600 |
8754-8755 |
'' |
denotes |
” |
T2601 |
8755-8756 |
-RRB- |
denotes |
) |
T2602 |
8756-8757 |
. |
denotes |
. |
T2603 |
8757-8935 |
sentence |
denotes |
Thus, Cre-recombinase removes in forebrain neurons the intronic TK-neo gene, leading to the active GluR-BΔECS allele for Q/R site-unedited GluR-B(Q) subunits (Figures 1 and S1). |
T2604 |
8758-8762 |
RB |
denotes |
Thus |
T2605 |
8780-8787 |
VBZ |
denotes |
removes |
T2606 |
8762-8764 |
, |
denotes |
, |
T2607 |
8764-8767 |
NN |
denotes |
Cre |
T2608 |
8768-8779 |
NN |
denotes |
recombinase |
T2609 |
8767-8768 |
HYPH |
denotes |
- |
T2610 |
8788-8790 |
IN |
denotes |
in |
T2611 |
8791-8800 |
NN |
denotes |
forebrain |
T2612 |
8801-8808 |
NNS |
denotes |
neurons |
T2613 |
8809-8812 |
DT |
denotes |
the |
T2614 |
8829-8833 |
NN |
denotes |
gene |
T2615 |
8813-8821 |
JJ |
denotes |
intronic |
T2616 |
8822-8824 |
NN |
denotes |
TK |
T2617 |
8825-8828 |
NN |
denotes |
neo |
T2618 |
8824-8825 |
HYPH |
denotes |
- |
T2619 |
8833-8835 |
, |
denotes |
, |
T2620 |
8835-8842 |
VBG |
denotes |
leading |
T2621 |
8843-8845 |
IN |
denotes |
to |
T2622 |
8846-8849 |
DT |
denotes |
the |
T2623 |
8868-8874 |
NN |
denotes |
allele |
T2624 |
8850-8856 |
JJ |
denotes |
active |
T2625 |
8857-8861 |
NN |
denotes |
GluR |
T2626 |
8862-8867 |
NN |
denotes |
BΔECS |
T2627 |
8861-8862 |
HYPH |
denotes |
- |
T2628 |
8875-8878 |
IN |
denotes |
for |
T2629 |
8879-8880 |
NN |
denotes |
Q |
T2630 |
8881-8882 |
NN |
denotes |
R |
T2631 |
8880-8881 |
HYPH |
denotes |
/ |
T2632 |
8883-8887 |
NN |
denotes |
site |
T2633 |
8888-8896 |
JJ |
denotes |
unedited |
T2634 |
8887-8888 |
HYPH |
denotes |
- |
T2635 |
8907-8915 |
NNS |
denotes |
subunits |
T2636 |
8897-8901 |
NN |
denotes |
GluR |
T2637 |
8902-8903 |
NN |
denotes |
B |
T2638 |
8901-8902 |
HYPH |
denotes |
- |
T2639 |
8903-8904 |
-LRB- |
denotes |
( |
T2640 |
8904-8905 |
NN |
denotes |
Q |
T2641 |
8905-8906 |
-RRB- |
denotes |
) |
T2642 |
8916-8917 |
-LRB- |
denotes |
( |
T2643 |
8931-8933 |
NN |
denotes |
S1 |
T2644 |
8917-8924 |
NNS |
denotes |
Figures |
T2645 |
8925-8926 |
CD |
denotes |
1 |
T2646 |
8927-8930 |
CC |
denotes |
and |
T2647 |
8933-8934 |
-RRB- |
denotes |
) |
T2648 |
8934-8935 |
. |
denotes |
. |
T2649 |
8935-9164 |
sentence |
denotes |
As expected [53,60], also in mice expressing postnatally forebrain-specific Q/R site-unedited GluR-B(Q) subunits, Ca2+ permeability through AMPAR was increased and AMPAR currents showed rectification ([58] and unpublished data). |
T2650 |
8936-8938 |
IN |
denotes |
As |
T2651 |
8939-8947 |
VBN |
denotes |
expected |
T2652 |
9086-9095 |
VBN |
denotes |
increased |
T2653 |
8948-8949 |
-LRB- |
denotes |
[ |
T2654 |
8952-8954 |
CD |
denotes |
60 |
T2655 |
8949-8951 |
CD |
denotes |
53 |
T2656 |
8951-8952 |
, |
denotes |
, |
T2657 |
8954-8955 |
-RRB- |
denotes |
] |
T2658 |
8955-8957 |
, |
denotes |
, |
T2659 |
8957-8961 |
RB |
denotes |
also |
T2660 |
8962-8964 |
IN |
denotes |
in |
T2661 |
8965-8969 |
NNS |
denotes |
mice |
T2662 |
8970-8980 |
VBG |
denotes |
expressing |
T2663 |
8981-8992 |
RB |
denotes |
postnatally |
T2664 |
8993-9002 |
NN |
denotes |
forebrain |
T2665 |
9003-9011 |
JJ |
denotes |
specific |
T2666 |
9002-9003 |
HYPH |
denotes |
- |
T2667 |
9040-9048 |
NNS |
denotes |
subunits |
T2668 |
9012-9013 |
NN |
denotes |
Q |
T2669 |
9014-9015 |
NN |
denotes |
R |
T2670 |
9013-9014 |
HYPH |
denotes |
/ |
T2671 |
9016-9020 |
NN |
denotes |
site |
T2672 |
9021-9029 |
JJ |
denotes |
unedited |
T2673 |
9020-9021 |
HYPH |
denotes |
- |
T2674 |
9030-9034 |
NN |
denotes |
GluR |
T2675 |
9035-9036 |
NN |
denotes |
B |
T2676 |
9034-9035 |
HYPH |
denotes |
- |
T2677 |
9036-9037 |
-LRB- |
denotes |
( |
T2678 |
9037-9038 |
NN |
denotes |
Q |
T2679 |
9038-9039 |
-RRB- |
denotes |
) |
T2680 |
9048-9050 |
, |
denotes |
, |
T2681 |
9050-9053 |
NN |
denotes |
Ca2 |
T2682 |
9055-9067 |
NN |
denotes |
permeability |
T2683 |
9053-9054 |
SYM |
denotes |
+ |
T2684 |
9068-9075 |
IN |
denotes |
through |
T2685 |
9076-9081 |
NN |
denotes |
AMPAR |
T2686 |
9082-9085 |
VBD |
denotes |
was |
T2687 |
9096-9099 |
CC |
denotes |
and |
T2688 |
9100-9105 |
NN |
denotes |
AMPAR |
T2689 |
9106-9114 |
NNS |
denotes |
currents |
T2690 |
9115-9121 |
VBD |
denotes |
showed |
T2691 |
9122-9135 |
NN |
denotes |
rectification |
T2692 |
9136-9137 |
-LRB- |
denotes |
( |
T2693 |
9138-9140 |
CD |
denotes |
58 |
T2694 |
9137-9138 |
-LRB- |
denotes |
[ |
T2695 |
9140-9141 |
-RRB- |
denotes |
] |
T2696 |
9142-9145 |
CC |
denotes |
and |
T2697 |
9146-9157 |
JJ |
denotes |
unpublished |
T2698 |
9158-9162 |
NNS |
denotes |
data |
T2699 |
9162-9163 |
-RRB- |
denotes |
) |
T2700 |
9163-9164 |
. |
denotes |
. |
T2701 |
9164-9301 |
sentence |
denotes |
GluR-BΔECS:FB mice had, in contrast to mice expressing GluR-B(Q) globally, a prolonged lifespan and no severe developmental alterations. |
T2702 |
9165-9169 |
NN |
denotes |
GluR |
T2703 |
9170-9175 |
NN |
denotes |
BΔECS |
T2704 |
9169-9170 |
HYPH |
denotes |
- |
T2705 |
9179-9183 |
NNS |
denotes |
mice |
T2706 |
9175-9176 |
: |
denotes |
: |
T2707 |
9176-9178 |
NN |
denotes |
FB |
T2708 |
9184-9187 |
VBD |
denotes |
had |
T2709 |
9187-9189 |
, |
denotes |
, |
T2710 |
9189-9191 |
IN |
denotes |
in |
T2711 |
9192-9200 |
NN |
denotes |
contrast |
T2712 |
9201-9203 |
IN |
denotes |
to |
T2713 |
9204-9208 |
NNS |
denotes |
mice |
T2714 |
9209-9219 |
VBG |
denotes |
expressing |
T2715 |
9220-9224 |
NN |
denotes |
GluR |
T2716 |
9227-9228 |
NN |
denotes |
Q |
T2717 |
9224-9225 |
HYPH |
denotes |
- |
T2718 |
9225-9226 |
NN |
denotes |
B |
T2719 |
9226-9227 |
-LRB- |
denotes |
( |
T2720 |
9228-9229 |
-RRB- |
denotes |
) |
T2721 |
9230-9238 |
RB |
denotes |
globally |
T2722 |
9238-9240 |
, |
denotes |
, |
T2723 |
9240-9241 |
DT |
denotes |
a |
T2724 |
9252-9260 |
NN |
denotes |
lifespan |
T2725 |
9242-9251 |
VBN |
denotes |
prolonged |
T2726 |
9261-9264 |
CC |
denotes |
and |
T2727 |
9265-9267 |
DT |
denotes |
no |
T2728 |
9289-9300 |
NNS |
denotes |
alterations |
T2729 |
9268-9274 |
JJ |
denotes |
severe |
T2730 |
9275-9288 |
JJ |
denotes |
developmental |
T2731 |
9300-9301 |
. |
denotes |
. |
T2732 |
9301-9417 |
sentence |
denotes |
They were however, still seizure-prone [58], and hence behavioral training was restricted to short periods of time. |
T2733 |
9302-9306 |
PRP |
denotes |
They |
T2734 |
9307-9311 |
VBD |
denotes |
were |
T2735 |
9312-9319 |
RB |
denotes |
however |
T2736 |
9319-9321 |
, |
denotes |
, |
T2737 |
9321-9326 |
RB |
denotes |
still |
T2738 |
9327-9334 |
NN |
denotes |
seizure |
T2739 |
9335-9340 |
JJ |
denotes |
prone |
T2740 |
9334-9335 |
HYPH |
denotes |
- |
T2741 |
9341-9342 |
-LRB- |
denotes |
[ |
T2742 |
9342-9344 |
CD |
denotes |
58 |
T2743 |
9344-9345 |
-RRB- |
denotes |
] |
T2744 |
9345-9347 |
, |
denotes |
, |
T2745 |
9347-9350 |
CC |
denotes |
and |
T2746 |
9351-9356 |
RB |
denotes |
hence |
T2747 |
9381-9391 |
VBN |
denotes |
restricted |
T2748 |
9357-9367 |
JJ |
denotes |
behavioral |
T2749 |
9368-9376 |
NN |
denotes |
training |
T2750 |
9377-9380 |
VBD |
denotes |
was |
T2751 |
9392-9394 |
IN |
denotes |
to |
T2752 |
9395-9400 |
JJ |
denotes |
short |
T2753 |
9401-9408 |
NNS |
denotes |
periods |
T2754 |
9409-9411 |
IN |
denotes |
of |
T2755 |
9412-9416 |
NN |
denotes |
time |
T2756 |
9416-9417 |
. |
denotes |
. |
T2757 |
9417-11567 |
sentence |
denotes |
Figure 1 Odor Learning and Discrimination Is Enhanced in GluR-BΔECS:FB Mice
(A) Schematic diagram depicting Cre-mediated activation of GluR-B(Q) by removing the loxP-flanked TK-neo (TK-neo pA, GluR-Bneo) element in intron 11, which is acting as a suppressor in expression from the Q/R site editing deficient GluR-Bneo allele. Exon 10 and 11 encode membrane-spanning segments 1, 2, and 3 (M1, 2, 3) of the GluR-B subunit. The intronic element necessary for editing the Q/R site is shown for the wild-type allele (+).
(B) Scheme of an individual trial. Breaking a light barrier, the mouse initiates a trial. An odor is presented, and (depending on the odor denotation and the mouse's response) the mouse is rewarded or retracts its head. A small (2- to 4-μl) water reward is given at the end of an S+ odor if the mouse continuously licks at the delivery tube during the 2-s trial. A trial is counted as correct if the mouse licks continuously upon presentation of a rewarded (S+) odor or does not lick continuously with a nonrewarded (S−) odor [3].
(C) Twelve experimentally naïve animals (six GluR-BΔECS:FB [orange] and six GluR-B+/+ littermate controls [black]) were trained on 1% AA versus 1% EB for two tasks of 200 trials each. Both groups acquired the task (> 70% correct); however, the GluR-BΔECS:FB were both quicker, and performed better overall, than the littermate controls (group effect: F(1,10 ) = 10.2; p < 0.01). AA, amylacetate; EB, ethylbutyrate.
(D) Average head position for one mouse and 50 presentations of the S+ (green) and 50 presentations of the S− (red) odor. “1” indicates the breaking of the light beam (head in the sampling port [3]). Note the rapid head retraction for the S− odor.
(E) Difference of the average head positions from (D) for S+ and S− odors. Blue line indicates sigmoidal fit. “Discrimination index” refers to the maximum of the fitted sigmoid.
(F) As (C) but depicting the discrimination index as a function of trial number (group effect: F(1,10) = 1.7; p < 0.01). We trained six GluR-BΔECS:FB mice and six littermate controls on one odor pair in an automated go/no-go olfactory conditioning task [3,61]. |
T2758 |
11428-11430 |
PRP |
denotes |
We |
T2759 |
11431-11438 |
VBD |
denotes |
trained |
T2760 |
11439-11442 |
CD |
denotes |
six |
T2761 |
11457-11461 |
NNS |
denotes |
mice |
T2762 |
11443-11447 |
NN |
denotes |
GluR |
T2763 |
11448-11453 |
NN |
denotes |
BΔECS |
T2764 |
11447-11448 |
HYPH |
denotes |
- |
T2765 |
11453-11454 |
: |
denotes |
: |
T2766 |
11454-11456 |
NN |
denotes |
FB |
T2767 |
11462-11465 |
CC |
denotes |
and |
T2768 |
11466-11469 |
CD |
denotes |
six |
T2769 |
11481-11489 |
NNS |
denotes |
controls |
T2770 |
11470-11480 |
NN |
denotes |
littermate |
T2771 |
11490-11492 |
IN |
denotes |
on |
T2772 |
11493-11496 |
CD |
denotes |
one |
T2773 |
11502-11506 |
NN |
denotes |
pair |
T2774 |
11497-11501 |
NN |
denotes |
odor |
T2775 |
11507-11509 |
IN |
denotes |
in |
T2776 |
11510-11512 |
DT |
denotes |
an |
T2777 |
11555-11559 |
NN |
denotes |
task |
T2778 |
11513-11522 |
VBN |
denotes |
automated |
T2779 |
11523-11525 |
NN |
denotes |
go |
T2780 |
11525-11526 |
HYPH |
denotes |
/ |
T2781 |
11526-11528 |
DT |
denotes |
no |
T2782 |
11529-11531 |
NN |
denotes |
go |
T2783 |
11528-11529 |
HYPH |
denotes |
- |
T2784 |
11532-11541 |
JJ |
denotes |
olfactory |
T2785 |
11542-11554 |
NN |
denotes |
conditioning |
T2786 |
11560-11561 |
-LRB- |
denotes |
[ |
T2787 |
11563-11565 |
CD |
denotes |
61 |
T2788 |
11561-11562 |
CD |
denotes |
3 |
T2789 |
11562-11563 |
, |
denotes |
, |
T2790 |
11565-11566 |
-RRB- |
denotes |
] |
T2791 |
11566-11567 |
. |
denotes |
. |
T2792 |
11567-11722 |
sentence |
denotes |
In this task, water-deprived mice are trained to distinguish a water-rewarded odor (S+) and an unrewarded odor (S−) by their licking response (Figure 1B). |
T2793 |
11568-11570 |
IN |
denotes |
In |
T2794 |
11606-11613 |
VBN |
denotes |
trained |
T2795 |
11571-11575 |
DT |
denotes |
this |
T2796 |
11576-11580 |
NN |
denotes |
task |
T2797 |
11580-11582 |
, |
denotes |
, |
T2798 |
11582-11587 |
NN |
denotes |
water |
T2799 |
11588-11596 |
VBN |
denotes |
deprived |
T2800 |
11587-11588 |
HYPH |
denotes |
- |
T2801 |
11597-11601 |
NNS |
denotes |
mice |
T2802 |
11602-11605 |
VBP |
denotes |
are |
T2803 |
11614-11616 |
TO |
denotes |
to |
T2804 |
11617-11628 |
VB |
denotes |
distinguish |
T2805 |
11629-11630 |
DT |
denotes |
a |
T2806 |
11646-11650 |
NN |
denotes |
odor |
T2807 |
11631-11636 |
NN |
denotes |
water |
T2808 |
11637-11645 |
VBN |
denotes |
rewarded |
T2809 |
11636-11637 |
HYPH |
denotes |
- |
T2810 |
11651-11652 |
-LRB- |
denotes |
( |
T2811 |
11652-11653 |
NN |
denotes |
S |
T2812 |
11653-11654 |
SYM |
denotes |
+ |
T2813 |
11654-11655 |
-RRB- |
denotes |
) |
T2814 |
11656-11659 |
CC |
denotes |
and |
T2815 |
11660-11662 |
DT |
denotes |
an |
T2816 |
11674-11678 |
NN |
denotes |
odor |
T2817 |
11663-11673 |
JJ |
denotes |
unrewarded |
T2818 |
11679-11680 |
-LRB- |
denotes |
( |
T2819 |
11680-11681 |
NN |
denotes |
S |
T2820 |
11681-11682 |
SYM |
denotes |
− |
T2821 |
11682-11683 |
-RRB- |
denotes |
) |
T2822 |
11684-11686 |
IN |
denotes |
by |
T2823 |
11687-11692 |
PRP$ |
denotes |
their |
T2824 |
11701-11709 |
NN |
denotes |
response |
T2825 |
11693-11700 |
NN |
denotes |
licking |
T2826 |
11710-11711 |
-LRB- |
denotes |
( |
T2827 |
11718-11720 |
NN |
denotes |
1B |
T2828 |
11711-11717 |
NN |
denotes |
Figure |
T2829 |
11720-11721 |
-RRB- |
denotes |
) |
T2830 |
11721-11722 |
. |
denotes |
. |
T2831 |
11722-11908 |
sentence |
denotes |
Both GluR-BΔECS:FB and control mice acquired the “simple” task to discriminate between the monomolecular odors amylacetate and ethylbutyrate (percentage correct > 70% after 400 trials). |
T2832 |
11723-11727 |
CC |
denotes |
Both |
T2833 |
11733-11738 |
NN |
denotes |
BΔECS |
T2834 |
11728-11732 |
NN |
denotes |
GluR |
T2835 |
11732-11733 |
HYPH |
denotes |
- |
T2836 |
11759-11767 |
VBD |
denotes |
acquired |
T2837 |
11738-11739 |
: |
denotes |
: |
T2838 |
11739-11741 |
NN |
denotes |
FB |
T2839 |
11742-11745 |
CC |
denotes |
and |
T2840 |
11746-11753 |
NN |
denotes |
control |
T2841 |
11754-11758 |
NNS |
denotes |
mice |
T2842 |
11768-11771 |
DT |
denotes |
the |
T2843 |
11781-11785 |
NN |
denotes |
task |
T2844 |
11772-11773 |
`` |
denotes |
“ |
T2845 |
11773-11779 |
JJ |
denotes |
simple |
T2846 |
11779-11780 |
'' |
denotes |
” |
T2847 |
11786-11788 |
TO |
denotes |
to |
T2848 |
11789-11801 |
VB |
denotes |
discriminate |
T2849 |
11802-11809 |
IN |
denotes |
between |
T2850 |
11810-11813 |
DT |
denotes |
the |
T2851 |
11828-11833 |
NNS |
denotes |
odors |
T2852 |
11814-11827 |
JJ |
denotes |
monomolecular |
T2853 |
11834-11845 |
NN |
denotes |
amylacetate |
T2854 |
11846-11849 |
CC |
denotes |
and |
T2855 |
11850-11863 |
NN |
denotes |
ethylbutyrate |
T2856 |
11864-11865 |
-LRB- |
denotes |
( |
T2857 |
11888-11889 |
NN |
denotes |
% |
T2858 |
11865-11875 |
NN |
denotes |
percentage |
T2859 |
11876-11883 |
JJ |
denotes |
correct |
T2860 |
11884-11885 |
SYM |
denotes |
> |
T2861 |
11886-11888 |
CD |
denotes |
70 |
T2862 |
11890-11895 |
IN |
denotes |
after |
T2863 |
11896-11899 |
CD |
denotes |
400 |
T2864 |
11900-11906 |
NNS |
denotes |
trials |
T2865 |
11906-11907 |
-RRB- |
denotes |
) |
T2866 |
11907-11908 |
. |
denotes |
. |
T2867 |
11908-12060 |
sentence |
denotes |
Strikingly, GluR-BΔECS:FB mice showed more rapid learning and enhanced discrimination capabilities (Figure 1C, group effect: F(1,10) = 10.2, p < 0.01). |
T2868 |
11909-11919 |
RB |
denotes |
Strikingly |
T2869 |
11940-11946 |
VBD |
denotes |
showed |
T2870 |
11919-11921 |
, |
denotes |
, |
T2871 |
11921-11925 |
NN |
denotes |
GluR |
T2872 |
11926-11931 |
NN |
denotes |
BΔECS |
T2873 |
11925-11926 |
HYPH |
denotes |
- |
T2874 |
11935-11939 |
NNS |
denotes |
mice |
T2875 |
11931-11932 |
: |
denotes |
: |
T2876 |
11932-11934 |
NN |
denotes |
FB |
T2877 |
11947-11951 |
RBR |
denotes |
more |
T2878 |
11952-11957 |
JJ |
denotes |
rapid |
T2879 |
11958-11966 |
NN |
denotes |
learning |
T2880 |
11967-11970 |
CC |
denotes |
and |
T2881 |
11971-11979 |
VBN |
denotes |
enhanced |
T2882 |
11995-12007 |
NNS |
denotes |
capabilities |
T2883 |
11980-11994 |
NN |
denotes |
discrimination |
T2884 |
12008-12009 |
-LRB- |
denotes |
( |
T2885 |
12016-12018 |
NN |
denotes |
1C |
T2886 |
12009-12015 |
NN |
denotes |
Figure |
T2887 |
12018-12020 |
, |
denotes |
, |
T2888 |
12020-12025 |
NN |
denotes |
group |
T2889 |
12026-12032 |
NN |
denotes |
effect |
T2890 |
12054-12058 |
CD |
denotes |
0.01 |
T2891 |
12032-12034 |
: |
denotes |
: |
T2892 |
12034-12035 |
NN |
denotes |
F |
T2893 |
12044-12048 |
CD |
denotes |
10.2 |
T2894 |
12035-12036 |
-LRB- |
denotes |
( |
T2895 |
12036-12037 |
CD |
denotes |
1 |
T2896 |
12037-12038 |
, |
denotes |
, |
T2897 |
12038-12040 |
CD |
denotes |
10 |
T2898 |
12040-12041 |
-RRB- |
denotes |
) |
T2899 |
12042-12043 |
SYM |
denotes |
= |
T2900 |
12048-12050 |
, |
denotes |
, |
T2901 |
12050-12051 |
NN |
denotes |
p |
T2902 |
12052-12053 |
SYM |
denotes |
< |
T2903 |
12058-12059 |
-RRB- |
denotes |
) |
T2904 |
12059-12060 |
. |
denotes |
. |
T2905 |
12060-12208 |
sentence |
denotes |
This was confirmed by fitting linear trend lines to the initial part of the learning curve (slope difference: p < 0.05; see Materials and Methods). |
T2906 |
12061-12065 |
DT |
denotes |
This |
T2907 |
12070-12079 |
VBN |
denotes |
confirmed |
T2908 |
12066-12069 |
VBD |
denotes |
was |
T2909 |
12080-12082 |
IN |
denotes |
by |
T2910 |
12083-12090 |
VBG |
denotes |
fitting |
T2911 |
12091-12097 |
JJ |
denotes |
linear |
T2912 |
12104-12109 |
NNS |
denotes |
lines |
T2913 |
12098-12103 |
NN |
denotes |
trend |
T2914 |
12110-12112 |
IN |
denotes |
to |
T2915 |
12113-12116 |
DT |
denotes |
the |
T2916 |
12125-12129 |
NN |
denotes |
part |
T2917 |
12117-12124 |
JJ |
denotes |
initial |
T2918 |
12130-12132 |
IN |
denotes |
of |
T2919 |
12133-12136 |
DT |
denotes |
the |
T2920 |
12146-12151 |
NN |
denotes |
curve |
T2921 |
12137-12145 |
NN |
denotes |
learning |
T2922 |
12152-12153 |
-LRB- |
denotes |
( |
T2923 |
12181-12184 |
VB |
denotes |
see |
T2924 |
12153-12158 |
NN |
denotes |
slope |
T2925 |
12159-12169 |
NN |
denotes |
difference |
T2926 |
12171-12172 |
NN |
denotes |
p |
T2927 |
12169-12171 |
: |
denotes |
: |
T2928 |
12173-12174 |
SYM |
denotes |
< |
T2929 |
12175-12179 |
CD |
denotes |
0.05 |
T2930 |
12179-12180 |
: |
denotes |
; |
T2931 |
12185-12194 |
NNS |
denotes |
Materials |
T2932 |
12195-12198 |
CC |
denotes |
and |
T2933 |
12199-12206 |
NNS |
denotes |
Methods |
T2934 |
12206-12207 |
-RRB- |
denotes |
) |
T2935 |
12207-12208 |
. |
denotes |
. |
T2936 |
12208-12290 |
sentence |
denotes |
The training system employed allows for careful monitoring of head positions [3]. |
T2937 |
12209-12212 |
DT |
denotes |
The |
T2938 |
12222-12228 |
NN |
denotes |
system |
T2939 |
12213-12221 |
NN |
denotes |
training |
T2940 |
12238-12244 |
VBZ |
denotes |
allows |
T2941 |
12229-12237 |
VBN |
denotes |
employed |
T2942 |
12245-12248 |
IN |
denotes |
for |
T2943 |
12249-12256 |
JJ |
denotes |
careful |
T2944 |
12257-12267 |
NN |
denotes |
monitoring |
T2945 |
12268-12270 |
IN |
denotes |
of |
T2946 |
12271-12275 |
NN |
denotes |
head |
T2947 |
12276-12285 |
NNS |
denotes |
positions |
T2948 |
12286-12287 |
-LRB- |
denotes |
[ |
T2949 |
12287-12288 |
CD |
denotes |
3 |
T2950 |
12288-12289 |
-RRB- |
denotes |
] |
T2951 |
12289-12290 |
. |
denotes |
. |
T2952 |
12290-12531 |
sentence |
denotes |
For rewarded trials (Figure 1D, green), already weakly trained animals kept their head in the sampling port (large tube in Figure 1B) during the entire 2-s trial, whereas for unrewarded trials the head is retracted quickly (Figure 1D, red). |
T2953 |
12291-12294 |
IN |
denotes |
For |
T2954 |
12362-12366 |
VBD |
denotes |
kept |
T2955 |
12295-12303 |
VBN |
denotes |
rewarded |
T2956 |
12304-12310 |
NNS |
denotes |
trials |
T2957 |
12311-12312 |
-LRB- |
denotes |
( |
T2958 |
12319-12321 |
NN |
denotes |
1D |
T2959 |
12312-12318 |
NN |
denotes |
Figure |
T2960 |
12321-12323 |
, |
denotes |
, |
T2961 |
12323-12328 |
JJ |
denotes |
green |
T2962 |
12328-12329 |
-RRB- |
denotes |
) |
T2963 |
12329-12331 |
, |
denotes |
, |
T2964 |
12331-12338 |
RB |
denotes |
already |
T2965 |
12346-12353 |
VBN |
denotes |
trained |
T2966 |
12339-12345 |
RB |
denotes |
weakly |
T2967 |
12354-12361 |
NNS |
denotes |
animals |
T2968 |
12367-12372 |
PRP$ |
denotes |
their |
T2969 |
12373-12377 |
NN |
denotes |
head |
T2970 |
12378-12380 |
IN |
denotes |
in |
T2971 |
12381-12384 |
DT |
denotes |
the |
T2972 |
12394-12398 |
NN |
denotes |
port |
T2973 |
12385-12393 |
NN |
denotes |
sampling |
T2974 |
12399-12400 |
-LRB- |
denotes |
( |
T2975 |
12406-12410 |
NN |
denotes |
tube |
T2976 |
12400-12405 |
JJ |
denotes |
large |
T2977 |
12411-12413 |
IN |
denotes |
in |
T2978 |
12414-12420 |
NN |
denotes |
Figure |
T2979 |
12421-12423 |
NN |
denotes |
1B |
T2980 |
12423-12424 |
-RRB- |
denotes |
) |
T2981 |
12425-12431 |
IN |
denotes |
during |
T2982 |
12432-12435 |
DT |
denotes |
the |
T2983 |
12447-12452 |
NN |
denotes |
trial |
T2984 |
12436-12442 |
JJ |
denotes |
entire |
T2985 |
12443-12444 |
CD |
denotes |
2 |
T2986 |
12445-12446 |
NN |
denotes |
s |
T2987 |
12444-12445 |
HYPH |
denotes |
- |
T2988 |
12452-12454 |
, |
denotes |
, |
T2989 |
12454-12461 |
IN |
denotes |
whereas |
T2990 |
12496-12505 |
VBN |
denotes |
retracted |
T2991 |
12462-12465 |
IN |
denotes |
for |
T2992 |
12466-12476 |
JJ |
denotes |
unrewarded |
T2993 |
12477-12483 |
NNS |
denotes |
trials |
T2994 |
12484-12487 |
DT |
denotes |
the |
T2995 |
12488-12492 |
NN |
denotes |
head |
T2996 |
12493-12495 |
VBZ |
denotes |
is |
T2997 |
12506-12513 |
RB |
denotes |
quickly |
T2998 |
12514-12515 |
-LRB- |
denotes |
( |
T2999 |
12522-12524 |
NN |
denotes |
1D |
T3000 |
12515-12521 |
NN |
denotes |
Figure |
T3001 |
12524-12526 |
, |
denotes |
, |
T3002 |
12526-12529 |
JJ |
denotes |
red |
T3003 |
12529-12530 |
-RRB- |
denotes |
) |
T3004 |
12530-12531 |
. |
denotes |
. |
T3005 |
12531-12900 |
sentence |
denotes |
The difference of these two curves (Figure 1E, black) is a very sensitive assay for discrimination performance; the fitted maximum of this curve (Figure 1E, blue) is referred to as the “discrimination index” in the remainder of the paper and is again strongly improved for GluR-BΔECS:FB mice, compared with controls (Figure 1F; group effect: F(1,10) = 11.7, p < 0.01). |
T3006 |
12532-12535 |
DT |
denotes |
The |
T3007 |
12536-12546 |
NN |
denotes |
difference |
T3008 |
12586-12588 |
VBZ |
denotes |
is |
T3009 |
12547-12549 |
IN |
denotes |
of |
T3010 |
12550-12555 |
DT |
denotes |
these |
T3011 |
12560-12566 |
NNS |
denotes |
curves |
T3012 |
12556-12559 |
CD |
denotes |
two |
T3013 |
12567-12568 |
-LRB- |
denotes |
( |
T3014 |
12575-12577 |
NN |
denotes |
1E |
T3015 |
12568-12574 |
NN |
denotes |
Figure |
T3016 |
12577-12579 |
, |
denotes |
, |
T3017 |
12579-12584 |
JJ |
denotes |
black |
T3018 |
12584-12585 |
-RRB- |
denotes |
) |
T3019 |
12698-12706 |
VBN |
denotes |
referred |
T3020 |
12589-12590 |
DT |
denotes |
a |
T3021 |
12606-12611 |
NN |
denotes |
assay |
T3022 |
12591-12595 |
RB |
denotes |
very |
T3023 |
12596-12605 |
JJ |
denotes |
sensitive |
T3024 |
12612-12615 |
IN |
denotes |
for |
T3025 |
12616-12630 |
NN |
denotes |
discrimination |
T3026 |
12631-12642 |
NN |
denotes |
performance |
T3027 |
12642-12643 |
: |
denotes |
; |
T3028 |
12644-12647 |
DT |
denotes |
the |
T3029 |
12655-12662 |
NN |
denotes |
maximum |
T3030 |
12648-12654 |
JJ |
denotes |
fitted |
T3031 |
12663-12665 |
IN |
denotes |
of |
T3032 |
12666-12670 |
DT |
denotes |
this |
T3033 |
12671-12676 |
NN |
denotes |
curve |
T3034 |
12677-12678 |
-LRB- |
denotes |
( |
T3035 |
12685-12687 |
NN |
denotes |
1E |
T3036 |
12678-12684 |
NN |
denotes |
Figure |
T3037 |
12687-12689 |
, |
denotes |
, |
T3038 |
12689-12693 |
JJ |
denotes |
blue |
T3039 |
12693-12694 |
-RRB- |
denotes |
) |
T3040 |
12695-12697 |
VBZ |
denotes |
is |
T3041 |
12707-12709 |
IN |
denotes |
to |
T3042 |
12710-12712 |
IN |
denotes |
as |
T3043 |
12713-12716 |
DT |
denotes |
the |
T3044 |
12733-12738 |
NN |
denotes |
index |
T3045 |
12717-12718 |
`` |
denotes |
“ |
T3046 |
12718-12732 |
NN |
denotes |
discrimination |
T3047 |
12738-12739 |
'' |
denotes |
” |
T3048 |
12740-12742 |
IN |
denotes |
in |
T3049 |
12743-12746 |
DT |
denotes |
the |
T3050 |
12747-12756 |
NN |
denotes |
remainder |
T3051 |
12757-12759 |
IN |
denotes |
of |
T3052 |
12760-12763 |
DT |
denotes |
the |
T3053 |
12764-12769 |
NN |
denotes |
paper |
T3054 |
12770-12773 |
CC |
denotes |
and |
T3055 |
12774-12776 |
VBZ |
denotes |
is |
T3056 |
12792-12800 |
VBN |
denotes |
improved |
T3057 |
12777-12782 |
RB |
denotes |
again |
T3058 |
12783-12791 |
RB |
denotes |
strongly |
T3059 |
12801-12804 |
IN |
denotes |
for |
T3060 |
12805-12809 |
NN |
denotes |
GluR |
T3061 |
12810-12815 |
NN |
denotes |
BΔECS |
T3062 |
12809-12810 |
HYPH |
denotes |
- |
T3063 |
12819-12823 |
NNS |
denotes |
mice |
T3064 |
12815-12816 |
: |
denotes |
: |
T3065 |
12816-12818 |
NN |
denotes |
FB |
T3066 |
12823-12825 |
, |
denotes |
, |
T3067 |
12825-12833 |
VBN |
denotes |
compared |
T3068 |
12834-12838 |
IN |
denotes |
with |
T3069 |
12839-12847 |
NNS |
denotes |
controls |
T3070 |
12848-12849 |
-LRB- |
denotes |
( |
T3071 |
12856-12858 |
NN |
denotes |
1F |
T3072 |
12849-12855 |
NN |
denotes |
Figure |
T3073 |
12858-12859 |
: |
denotes |
; |
T3074 |
12860-12865 |
NN |
denotes |
group |
T3075 |
12866-12872 |
NN |
denotes |
effect |
T3076 |
12894-12898 |
CD |
denotes |
0.01 |
T3077 |
12872-12874 |
: |
denotes |
: |
T3078 |
12874-12875 |
NN |
denotes |
F |
T3079 |
12884-12888 |
CD |
denotes |
11.7 |
T3080 |
12875-12876 |
-LRB- |
denotes |
( |
T3081 |
12876-12877 |
CD |
denotes |
1 |
T3082 |
12877-12878 |
, |
denotes |
, |
T3083 |
12878-12880 |
CD |
denotes |
10 |
T3084 |
12880-12881 |
-RRB- |
denotes |
) |
T3085 |
12882-12883 |
SYM |
denotes |
= |
T3086 |
12888-12890 |
, |
denotes |
, |
T3087 |
12890-12891 |
NN |
denotes |
p |
T3088 |
12892-12893 |
SYM |
denotes |
< |
T3089 |
12898-12899 |
-RRB- |
denotes |
) |
T3090 |
12899-12900 |
. |
denotes |
. |
T3091 |
12900-13144 |
sentence |
denotes |
This was not due to general motor performance, attention, or motivation changes, as both the intertrial interval (group effect: F(1,10) = 0.56, p > 0.4) and the overall licking frequency (group effect: F(1,10) = 0.72, p > 0.4) were unaffected. |
T3092 |
12901-12905 |
DT |
denotes |
This |
T3093 |
12906-12909 |
VBD |
denotes |
was |
T3094 |
12910-12913 |
RB |
denotes |
not |
T3095 |
12914-12917 |
IN |
denotes |
due |
T3096 |
12918-12920 |
IN |
denotes |
to |
T3097 |
12921-12928 |
JJ |
denotes |
general |
T3098 |
12935-12946 |
NN |
denotes |
performance |
T3099 |
12929-12934 |
NN |
denotes |
motor |
T3100 |
12946-12948 |
, |
denotes |
, |
T3101 |
12948-12957 |
NN |
denotes |
attention |
T3102 |
12957-12959 |
, |
denotes |
, |
T3103 |
12959-12961 |
CC |
denotes |
or |
T3104 |
12962-12972 |
NN |
denotes |
motivation |
T3105 |
12973-12980 |
NNS |
denotes |
changes |
T3106 |
12980-12982 |
, |
denotes |
, |
T3107 |
12982-12984 |
IN |
denotes |
as |
T3108 |
13128-13132 |
VBD |
denotes |
were |
T3109 |
12985-12989 |
CC |
denotes |
both |
T3110 |
13005-13013 |
NN |
denotes |
interval |
T3111 |
12990-12993 |
DT |
denotes |
the |
T3112 |
12994-13004 |
JJ |
denotes |
intertrial |
T3113 |
13014-13015 |
-LRB- |
denotes |
( |
T3114 |
13021-13027 |
NN |
denotes |
effect |
T3115 |
13015-13020 |
NN |
denotes |
group |
T3116 |
13027-13029 |
: |
denotes |
: |
T3117 |
13029-13030 |
NN |
denotes |
F |
T3118 |
13039-13043 |
CD |
denotes |
0.56 |
T3119 |
13030-13031 |
-LRB- |
denotes |
( |
T3120 |
13031-13032 |
CD |
denotes |
1 |
T3121 |
13032-13033 |
, |
denotes |
, |
T3122 |
13033-13035 |
CD |
denotes |
10 |
T3123 |
13035-13036 |
-RRB- |
denotes |
) |
T3124 |
13037-13038 |
SYM |
denotes |
= |
T3125 |
13049-13052 |
CD |
denotes |
0.4 |
T3126 |
13043-13045 |
, |
denotes |
, |
T3127 |
13045-13046 |
NN |
denotes |
p |
T3128 |
13047-13048 |
SYM |
denotes |
> |
T3129 |
13052-13053 |
-RRB- |
denotes |
) |
T3130 |
13054-13057 |
CC |
denotes |
and |
T3131 |
13058-13061 |
DT |
denotes |
the |
T3132 |
13078-13087 |
NN |
denotes |
frequency |
T3133 |
13062-13069 |
JJ |
denotes |
overall |
T3134 |
13070-13077 |
NN |
denotes |
licking |
T3135 |
13088-13089 |
-LRB- |
denotes |
( |
T3136 |
13095-13101 |
NN |
denotes |
effect |
T3137 |
13089-13094 |
NN |
denotes |
group |
T3138 |
13101-13103 |
: |
denotes |
: |
T3139 |
13103-13104 |
NN |
denotes |
F |
T3140 |
13113-13117 |
CD |
denotes |
0.72 |
T3141 |
13104-13105 |
-LRB- |
denotes |
( |
T3142 |
13105-13106 |
CD |
denotes |
1 |
T3143 |
13106-13107 |
, |
denotes |
, |
T3144 |
13107-13109 |
CD |
denotes |
10 |
T3145 |
13109-13110 |
-RRB- |
denotes |
) |
T3146 |
13111-13112 |
SYM |
denotes |
= |
T3147 |
13123-13126 |
CD |
denotes |
0.4 |
T3148 |
13117-13119 |
, |
denotes |
, |
T3149 |
13119-13120 |
NN |
denotes |
p |
T3150 |
13121-13122 |
SYM |
denotes |
> |
T3151 |
13126-13127 |
-RRB- |
denotes |
) |
T3152 |
13133-13143 |
JJ |
denotes |
unaffected |
T3153 |
13143-13144 |
. |
denotes |
. |
T3154 |
13144-13312 |
sentence |
denotes |
Thus, expression of Ca2+-permeable AMPARs in forebrain areas, including the olfactory bulb, resulted in more rapid odor learning and enhanced olfactory discrimination. |
T3155 |
13145-13149 |
RB |
denotes |
Thus |
T3156 |
13237-13245 |
VBD |
denotes |
resulted |
T3157 |
13149-13151 |
, |
denotes |
, |
T3158 |
13151-13161 |
NN |
denotes |
expression |
T3159 |
13162-13164 |
IN |
denotes |
of |
T3160 |
13165-13168 |
NN |
denotes |
Ca2 |
T3161 |
13170-13179 |
JJ |
denotes |
permeable |
T3162 |
13168-13169 |
SYM |
denotes |
+ |
T3163 |
13169-13170 |
HYPH |
denotes |
- |
T3164 |
13180-13186 |
NNS |
denotes |
AMPARs |
T3165 |
13187-13189 |
IN |
denotes |
in |
T3166 |
13190-13199 |
NN |
denotes |
forebrain |
T3167 |
13200-13205 |
NNS |
denotes |
areas |
T3168 |
13205-13207 |
, |
denotes |
, |
T3169 |
13207-13216 |
VBG |
denotes |
including |
T3170 |
13217-13220 |
DT |
denotes |
the |
T3171 |
13231-13235 |
NN |
denotes |
bulb |
T3172 |
13221-13230 |
JJ |
denotes |
olfactory |
T3173 |
13235-13237 |
, |
denotes |
, |
T3174 |
13246-13248 |
IN |
denotes |
in |
T3175 |
13249-13253 |
RBR |
denotes |
more |
T3176 |
13254-13259 |
JJ |
denotes |
rapid |
T3177 |
13265-13273 |
NN |
denotes |
learning |
T3178 |
13260-13264 |
NN |
denotes |
odor |
T3179 |
13274-13277 |
CC |
denotes |
and |
T3180 |
13278-13286 |
VBN |
denotes |
enhanced |
T3181 |
13297-13311 |
NN |
denotes |
discrimination |
T3182 |
13287-13296 |
JJ |
denotes |
olfactory |
T3183 |
13311-13312 |
. |
denotes |
. |
T3577 |
13314-13318 |
NN |
denotes |
GluR |
T3578 |
13319-13323 |
NN |
denotes |
BΔFB |
T3579 |
13318-13319 |
HYPH |
denotes |
- |
T3580 |
13324-13328 |
NNS |
denotes |
Mice |
T3581 |
13329-13336 |
VBP |
denotes |
Exhibit |
T3582 |
13337-13346 |
VBN |
denotes |
Increased |
T3583 |
13372-13383 |
NN |
denotes |
Performance |
T3584 |
13347-13356 |
NN |
denotes |
Olfactory |
T3585 |
13357-13371 |
NN |
denotes |
Discrimination |
T3586 |
13383-13622 |
sentence |
denotes |
To ascertain if enhanced olfactory learning and odor discrimination may indeed correlate with the increased Ca2+ permeability of AMPA channels in the Q/R site-unedited form, we next analyzed GluR-BΔFB mice, which lack GluR-B in forebrain. |
T3587 |
13384-13386 |
TO |
denotes |
To |
T3588 |
13387-13396 |
VB |
denotes |
ascertain |
T3589 |
13566-13574 |
VBD |
denotes |
analyzed |
T3590 |
13397-13399 |
IN |
denotes |
if |
T3591 |
13463-13472 |
VB |
denotes |
correlate |
T3592 |
13400-13408 |
VBN |
denotes |
enhanced |
T3593 |
13419-13427 |
NN |
denotes |
learning |
T3594 |
13409-13418 |
JJ |
denotes |
olfactory |
T3595 |
13428-13431 |
CC |
denotes |
and |
T3596 |
13432-13436 |
NN |
denotes |
odor |
T3597 |
13437-13451 |
NN |
denotes |
discrimination |
T3598 |
13452-13455 |
MD |
denotes |
may |
T3599 |
13456-13462 |
RB |
denotes |
indeed |
T3600 |
13473-13477 |
IN |
denotes |
with |
T3601 |
13478-13481 |
DT |
denotes |
the |
T3602 |
13497-13509 |
NN |
denotes |
permeability |
T3603 |
13482-13491 |
VBN |
denotes |
increased |
T3604 |
13492-13495 |
NN |
denotes |
Ca2 |
T3605 |
13495-13496 |
SYM |
denotes |
+ |
T3606 |
13510-13512 |
IN |
denotes |
of |
T3607 |
13513-13517 |
NN |
denotes |
AMPA |
T3608 |
13518-13526 |
NNS |
denotes |
channels |
T3609 |
13527-13529 |
IN |
denotes |
in |
T3610 |
13530-13533 |
DT |
denotes |
the |
T3611 |
13552-13556 |
NN |
denotes |
form |
T3612 |
13534-13535 |
NN |
denotes |
Q |
T3613 |
13536-13537 |
NN |
denotes |
R |
T3614 |
13535-13536 |
HYPH |
denotes |
/ |
T3615 |
13538-13542 |
NN |
denotes |
site |
T3616 |
13543-13551 |
JJ |
denotes |
unedited |
T3617 |
13542-13543 |
HYPH |
denotes |
- |
T3618 |
13556-13558 |
, |
denotes |
, |
T3619 |
13558-13560 |
PRP |
denotes |
we |
T3620 |
13561-13565 |
RB |
denotes |
next |
T3621 |
13575-13579 |
NN |
denotes |
GluR |
T3622 |
13580-13584 |
NN |
denotes |
BΔFB |
T3623 |
13579-13580 |
HYPH |
denotes |
- |
T3624 |
13585-13589 |
NNS |
denotes |
mice |
T3625 |
13589-13591 |
, |
denotes |
, |
T3626 |
13591-13596 |
WDT |
denotes |
which |
T3627 |
13597-13601 |
VBP |
denotes |
lack |
T3628 |
13602-13606 |
NN |
denotes |
GluR |
T3629 |
13607-13608 |
NN |
denotes |
B |
T3630 |
13606-13607 |
HYPH |
denotes |
- |
T3631 |
13609-13611 |
IN |
denotes |
in |
T3632 |
13612-13621 |
NN |
denotes |
forebrain |
T3633 |
13621-13622 |
. |
denotes |
. |
T3634 |
13622-13815 |
sentence |
denotes |
This specific ablation was generated by forebrain-selective TgCre4 expression ([59] “Camkcre4”) in gene-targeted GluR-B2lox mice carrying, in both GluR-B alleles, a floxed exon 11 (Figure 2A). |
T3635 |
13623-13627 |
DT |
denotes |
This |
T3636 |
13637-13645 |
NN |
denotes |
ablation |
T3637 |
13628-13636 |
JJ |
denotes |
specific |
T3638 |
13650-13659 |
VBN |
denotes |
generated |
T3639 |
13646-13649 |
VBD |
denotes |
was |
T3640 |
13660-13662 |
IN |
denotes |
by |
T3641 |
13663-13672 |
NN |
denotes |
forebrain |
T3642 |
13673-13682 |
JJ |
denotes |
selective |
T3643 |
13672-13673 |
HYPH |
denotes |
- |
T3644 |
13690-13700 |
NN |
denotes |
expression |
T3645 |
13683-13689 |
NN |
denotes |
TgCre4 |
T3646 |
13701-13702 |
-LRB- |
denotes |
( |
T3647 |
13708-13716 |
NN |
denotes |
Camkcre4 |
T3648 |
13702-13703 |
-LRB- |
denotes |
[ |
T3649 |
13703-13705 |
CD |
denotes |
59 |
T3650 |
13705-13706 |
-RRB- |
denotes |
] |
T3651 |
13707-13708 |
`` |
denotes |
“ |
T3652 |
13716-13717 |
'' |
denotes |
” |
T3653 |
13717-13718 |
-RRB- |
denotes |
) |
T3654 |
13719-13721 |
IN |
denotes |
in |
T3655 |
13722-13726 |
NN |
denotes |
gene |
T3656 |
13727-13735 |
VBN |
denotes |
targeted |
T3657 |
13726-13727 |
HYPH |
denotes |
- |
T3658 |
13747-13751 |
NNS |
denotes |
mice |
T3659 |
13736-13740 |
NN |
denotes |
GluR |
T3660 |
13741-13746 |
NN |
denotes |
B2lox |
T3661 |
13740-13741 |
HYPH |
denotes |
- |
T3662 |
13752-13760 |
VBG |
denotes |
carrying |
T3663 |
13760-13762 |
, |
denotes |
, |
T3664 |
13762-13764 |
IN |
denotes |
in |
T3665 |
13765-13769 |
CC |
denotes |
both |
T3666 |
13777-13784 |
NNS |
denotes |
alleles |
T3667 |
13770-13774 |
NN |
denotes |
GluR |
T3668 |
13775-13776 |
NN |
denotes |
B |
T3669 |
13774-13775 |
HYPH |
denotes |
- |
T3670 |
13784-13786 |
, |
denotes |
, |
T3671 |
13786-13787 |
DT |
denotes |
a |
T3672 |
13795-13799 |
NN |
denotes |
exon |
T3673 |
13788-13794 |
VBN |
denotes |
floxed |
T3674 |
13800-13802 |
CD |
denotes |
11 |
T3675 |
13803-13804 |
-LRB- |
denotes |
( |
T3676 |
13811-13813 |
NN |
denotes |
2A |
T3677 |
13804-13810 |
NN |
denotes |
Figure |
T3678 |
13813-13814 |
-RRB- |
denotes |
) |
T3679 |
13814-13815 |
. |
denotes |
. |
T3680 |
13815-13936 |
sentence |
denotes |
The specific GluR-B depletion in GluR-BΔFB mice can be monitored by immunohistochemistry (see below) and immunoblotting. |
T3681 |
13816-13819 |
DT |
denotes |
The |
T3682 |
13836-13845 |
NN |
denotes |
depletion |
T3683 |
13820-13828 |
JJ |
denotes |
specific |
T3684 |
13829-13833 |
NN |
denotes |
GluR |
T3685 |
13834-13835 |
NN |
denotes |
B |
T3686 |
13833-13834 |
HYPH |
denotes |
- |
T3687 |
13871-13880 |
VBN |
denotes |
monitored |
T3688 |
13846-13848 |
IN |
denotes |
in |
T3689 |
13849-13853 |
NN |
denotes |
GluR |
T3690 |
13854-13858 |
NN |
denotes |
BΔFB |
T3691 |
13853-13854 |
HYPH |
denotes |
- |
T3692 |
13859-13863 |
NNS |
denotes |
mice |
T3693 |
13864-13867 |
MD |
denotes |
can |
T3694 |
13868-13870 |
VB |
denotes |
be |
T3695 |
13881-13883 |
IN |
denotes |
by |
T3696 |
13884-13904 |
NN |
denotes |
immunohistochemistry |
T3697 |
13905-13906 |
-LRB- |
denotes |
( |
T3698 |
13906-13909 |
VB |
denotes |
see |
T3699 |
13910-13915 |
RB |
denotes |
below |
T3700 |
13915-13916 |
-RRB- |
denotes |
) |
T3701 |
13917-13920 |
CC |
denotes |
and |
T3702 |
13921-13935 |
NN |
denotes |
immunoblotting |
T3703 |
13935-13936 |
. |
denotes |
. |
T3704 |
13936-14184 |
sentence |
denotes |
In quantitative immunoblot analyses, we found GluR-B levels reduced to 28 ± 7%, 29 ± 8%, and 52 ± 9% (± SEM; n = 10) in the hippocampus, cortical areas, and olfactory bulb, respectively, relative to GluR-B levels in GluR-B2lox littermate controls. |
T3705 |
13937-13939 |
IN |
denotes |
In |
T3706 |
13977-13982 |
VBD |
denotes |
found |
T3707 |
13940-13952 |
JJ |
denotes |
quantitative |
T3708 |
13964-13972 |
NNS |
denotes |
analyses |
T3709 |
13953-13963 |
NN |
denotes |
immunoblot |
T3710 |
13972-13974 |
, |
denotes |
, |
T3711 |
13974-13976 |
PRP |
denotes |
we |
T3712 |
13983-13987 |
NN |
denotes |
GluR |
T3713 |
13988-13989 |
NN |
denotes |
B |
T3714 |
13987-13988 |
HYPH |
denotes |
- |
T3715 |
13990-13996 |
NNS |
denotes |
levels |
T3716 |
13997-14004 |
VBD |
denotes |
reduced |
T3717 |
14005-14007 |
IN |
denotes |
to |
T3718 |
14008-14010 |
CD |
denotes |
28 |
T3719 |
14013-14014 |
CD |
denotes |
7 |
T3720 |
14011-14012 |
SYM |
denotes |
± |
T3721 |
14014-14015 |
NN |
denotes |
% |
T3722 |
14015-14017 |
, |
denotes |
, |
T3723 |
14017-14019 |
CD |
denotes |
29 |
T3724 |
14022-14023 |
CD |
denotes |
8 |
T3725 |
14020-14021 |
SYM |
denotes |
± |
T3726 |
14023-14024 |
NN |
denotes |
% |
T3727 |
14024-14026 |
, |
denotes |
, |
T3728 |
14026-14029 |
CC |
denotes |
and |
T3729 |
14030-14032 |
CD |
denotes |
52 |
T3730 |
14035-14036 |
CD |
denotes |
9 |
T3731 |
14033-14034 |
SYM |
denotes |
± |
T3732 |
14036-14037 |
NN |
denotes |
% |
T3733 |
14038-14039 |
-LRB- |
denotes |
( |
T3734 |
14041-14044 |
NN |
denotes |
SEM |
T3735 |
14039-14040 |
SYM |
denotes |
± |
T3736 |
14044-14045 |
: |
denotes |
; |
T3737 |
14046-14047 |
NN |
denotes |
n |
T3738 |
14050-14052 |
CD |
denotes |
10 |
T3739 |
14048-14049 |
SYM |
denotes |
= |
T3740 |
14052-14053 |
-RRB- |
denotes |
) |
T3741 |
14054-14056 |
IN |
denotes |
in |
T3742 |
14057-14060 |
DT |
denotes |
the |
T3743 |
14061-14072 |
NN |
denotes |
hippocampus |
T3744 |
14072-14074 |
, |
denotes |
, |
T3745 |
14074-14082 |
JJ |
denotes |
cortical |
T3746 |
14083-14088 |
NNS |
denotes |
areas |
T3747 |
14088-14090 |
, |
denotes |
, |
T3748 |
14090-14093 |
CC |
denotes |
and |
T3749 |
14094-14103 |
JJ |
denotes |
olfactory |
T3750 |
14104-14108 |
NN |
denotes |
bulb |
T3751 |
14108-14110 |
, |
denotes |
, |
T3752 |
14110-14122 |
RB |
denotes |
respectively |
T3753 |
14122-14124 |
, |
denotes |
, |
T3754 |
14124-14132 |
JJ |
denotes |
relative |
T3755 |
14133-14135 |
IN |
denotes |
to |
T3756 |
14136-14140 |
NN |
denotes |
GluR |
T3757 |
14141-14142 |
NN |
denotes |
B |
T3758 |
14140-14141 |
HYPH |
denotes |
- |
T3759 |
14143-14149 |
NNS |
denotes |
levels |
T3760 |
14150-14152 |
IN |
denotes |
in |
T3761 |
14153-14157 |
NN |
denotes |
GluR |
T3762 |
14158-14163 |
NN |
denotes |
B2lox |
T3763 |
14157-14158 |
HYPH |
denotes |
- |
T3764 |
14175-14183 |
NNS |
denotes |
controls |
T3765 |
14164-14174 |
NN |
denotes |
littermate |
T3766 |
14183-14184 |
. |
denotes |
. |
T3767 |
14184-14424 |
sentence |
denotes |
In the absence of GluR-B, the electrophysiological properties of AMPA channels become similar to those with GluR-B/GluR-B(Q) switch [51] showing strong rectification and increased Ca2+ permeability through AMPA channels (unpublished data). |
T3768 |
14185-14187 |
IN |
denotes |
In |
T3769 |
14264-14270 |
VBP |
denotes |
become |
T3770 |
14188-14191 |
DT |
denotes |
the |
T3771 |
14192-14199 |
NN |
denotes |
absence |
T3772 |
14200-14202 |
IN |
denotes |
of |
T3773 |
14203-14207 |
NN |
denotes |
GluR |
T3774 |
14208-14209 |
NN |
denotes |
B |
T3775 |
14207-14208 |
HYPH |
denotes |
- |
T3776 |
14209-14211 |
, |
denotes |
, |
T3777 |
14211-14214 |
DT |
denotes |
the |
T3778 |
14236-14246 |
NNS |
denotes |
properties |
T3779 |
14215-14235 |
JJ |
denotes |
electrophysiological |
T3780 |
14247-14249 |
IN |
denotes |
of |
T3781 |
14250-14254 |
NN |
denotes |
AMPA |
T3782 |
14255-14263 |
NNS |
denotes |
channels |
T3783 |
14271-14278 |
JJ |
denotes |
similar |
T3784 |
14279-14281 |
IN |
denotes |
to |
T3785 |
14282-14287 |
DT |
denotes |
those |
T3786 |
14288-14292 |
IN |
denotes |
with |
T3787 |
14293-14297 |
NN |
denotes |
GluR |
T3788 |
14298-14299 |
NN |
denotes |
B |
T3789 |
14297-14298 |
HYPH |
denotes |
- |
T3790 |
14310-14316 |
NN |
denotes |
switch |
T3791 |
14299-14300 |
HYPH |
denotes |
/ |
T3792 |
14300-14304 |
NN |
denotes |
GluR |
T3793 |
14307-14308 |
NN |
denotes |
Q |
T3794 |
14304-14305 |
HYPH |
denotes |
- |
T3795 |
14305-14306 |
NN |
denotes |
B |
T3796 |
14306-14307 |
-LRB- |
denotes |
( |
T3797 |
14308-14309 |
-RRB- |
denotes |
) |
T3798 |
14317-14318 |
-LRB- |
denotes |
[ |
T3799 |
14318-14320 |
CD |
denotes |
51 |
T3800 |
14320-14321 |
-RRB- |
denotes |
] |
T3801 |
14322-14329 |
VBG |
denotes |
showing |
T3802 |
14330-14336 |
JJ |
denotes |
strong |
T3803 |
14337-14350 |
NN |
denotes |
rectification |
T3804 |
14351-14354 |
CC |
denotes |
and |
T3805 |
14355-14364 |
VBN |
denotes |
increased |
T3806 |
14370-14382 |
NN |
denotes |
permeability |
T3807 |
14365-14368 |
NN |
denotes |
Ca2 |
T3808 |
14368-14369 |
SYM |
denotes |
+ |
T3809 |
14383-14390 |
IN |
denotes |
through |
T3810 |
14391-14395 |
NN |
denotes |
AMPA |
T3811 |
14396-14404 |
NNS |
denotes |
channels |
T3812 |
14405-14406 |
-LRB- |
denotes |
( |
T3813 |
14418-14422 |
NNS |
denotes |
data |
T3814 |
14406-14417 |
JJ |
denotes |
unpublished |
T3815 |
14422-14423 |
-RRB- |
denotes |
) |
T3816 |
14423-14424 |
. |
denotes |
. |
T3817 |
14424-14495 |
sentence |
denotes |
However, GluR-B depletion is not lethal and does not produce seizures. |
T3818 |
14425-14432 |
RB |
denotes |
However |
T3819 |
14451-14453 |
VBZ |
denotes |
is |
T3820 |
14432-14434 |
, |
denotes |
, |
T3821 |
14434-14438 |
NN |
denotes |
GluR |
T3822 |
14439-14440 |
NN |
denotes |
B |
T3823 |
14438-14439 |
HYPH |
denotes |
- |
T3824 |
14954-14955 |
NN |
denotes |
p |
T3825 |
14441-14450 |
NN |
denotes |
depletion |
T3826 |
14454-14457 |
RB |
denotes |
not |
T3827 |
14458-14464 |
JJ |
denotes |
lethal |
T3828 |
14465-14468 |
CC |
denotes |
and |
T3829 |
14469-14473 |
VBZ |
denotes |
does |
T3830 |
14478-14485 |
VB |
denotes |
produce |
T3831 |
14474-14477 |
RB |
denotes |
not |
T3832 |
14486-14494 |
NNS |
denotes |
seizures |
T3833 |
14494-14495 |
. |
denotes |
. |
T3834 |
14495-14783 |
sentence |
denotes |
In addition, in contrast to the complete GluR-B knockouts, mice with forebrain-specific GluR-B depletion appeared normal throughout life with no developmental abnormalities, or difference in body size and weight in adulthood (wild-type: 31.0 g ± 1.2; GluR-BΔFB: 28.4 ± 0.9; each n = 10). |
T3835 |
14496-14498 |
IN |
denotes |
In |
T3836 |
14601-14609 |
VBD |
denotes |
appeared |
T5171 |
20322-20331 |
JJ |
denotes |
Olfactory |
T5172 |
20332-20338 |
NN |
denotes |
Memory |
T5173 |
20339-20341 |
VBZ |
denotes |
Is |
T5174 |
20342-20355 |
RB |
denotes |
Significantly |
T5175 |
20356-20365 |
VBN |
denotes |
Decreased |
T5176 |
20366-20369 |
CC |
denotes |
but |
T5177 |
20370-20376 |
RB |
denotes |
Highly |
T5178 |
20377-20385 |
JJ |
denotes |
Variable |
T5179 |
20386-20388 |
IN |
denotes |
in |
T5180 |
20389-20393 |
NN |
denotes |
GluR |
T5181 |
20394-20398 |
NN |
denotes |
BΔFB |
T5182 |
20393-20394 |
HYPH |
denotes |
- |
T5183 |
20399-20403 |
NNS |
denotes |
Mice |
T5184 |
20403-20565 |
sentence |
denotes |
To capture the full extent of the role of Ca2+-permeable AMPARs in olfactory behavior, we next assessed the effects of altered AMPA channels on olfactory memory. |
T5185 |
20404-20406 |
TO |
denotes |
To |
T5186 |
20407-20414 |
VB |
denotes |
capture |
T5187 |
20499-20507 |
VBD |
denotes |
assessed |
T5188 |
20415-20418 |
DT |
denotes |
the |
T5189 |
20424-20430 |
NN |
denotes |
extent |
T5190 |
20419-20423 |
JJ |
denotes |
full |
T5191 |
20431-20433 |
IN |
denotes |
of |
T5192 |
20434-20437 |
DT |
denotes |
the |
T5193 |
20438-20442 |
NN |
denotes |
role |
T5194 |
20443-20445 |
IN |
denotes |
of |
T5195 |
20446-20449 |
NN |
denotes |
Ca2 |
T5196 |
20451-20460 |
JJ |
denotes |
permeable |
T5197 |
20449-20450 |
SYM |
denotes |
+ |
T5198 |
20450-20451 |
HYPH |
denotes |
- |
T5199 |
20461-20467 |
NNS |
denotes |
AMPARs |
T5200 |
20468-20470 |
IN |
denotes |
in |
T5201 |
20471-20480 |
JJ |
denotes |
olfactory |
T5202 |
20481-20489 |
NN |
denotes |
behavior |
T5203 |
20489-20491 |
, |
denotes |
, |
T5204 |
20491-20493 |
PRP |
denotes |
we |
T5205 |
20494-20498 |
RB |
denotes |
next |
T5206 |
20508-20511 |
DT |
denotes |
the |
T5207 |
20512-20519 |
NNS |
denotes |
effects |
T5208 |
20520-20522 |
IN |
denotes |
of |
T5209 |
20523-20530 |
VBN |
denotes |
altered |
T5210 |
20536-20544 |
NNS |
denotes |
channels |
T5211 |
20531-20535 |
NN |
denotes |
AMPA |
T5212 |
20545-20547 |
IN |
denotes |
on |
T5213 |
20548-20557 |
JJ |
denotes |
olfactory |
T5214 |
20558-20564 |
NN |
denotes |
memory |
T5215 |
20564-20565 |
. |
denotes |
. |
T5216 |
20565-20923 |
sentence |
denotes |
To probe olfactory memory in GluR-BΔFB mice, six days after the end of the first training phase for odor discrimination (amylacetate versus ethylbutyrate), the training trials for the third odor pair (pelargonic versus valeric acid) were interleaved with unrewarded trials in which amylacetate or ethylbutyrate were again presented (black bar in Figure 2C). |
T5217 |
20566-20568 |
TO |
denotes |
To |
T5218 |
20569-20574 |
VB |
denotes |
probe |
T5219 |
20804-20815 |
VBN |
denotes |
interleaved |
T5220 |
20575-20584 |
JJ |
denotes |
olfactory |
T5221 |
20585-20591 |
NN |
denotes |
memory |
T5222 |
20592-20594 |
IN |
denotes |
in |
T5223 |
20595-20599 |
NN |
denotes |
GluR |
T5224 |
20600-20604 |
NN |
denotes |
BΔFB |
T5225 |
20599-20600 |
HYPH |
denotes |
- |
T5226 |
20605-20609 |
NNS |
denotes |
mice |
T5227 |
20609-20611 |
, |
denotes |
, |
T5228 |
20611-20614 |
CD |
denotes |
six |
T5229 |
20615-20619 |
NNS |
denotes |
days |
T5230 |
20620-20625 |
IN |
denotes |
after |
T5231 |
20626-20629 |
DT |
denotes |
the |
T5232 |
20630-20633 |
NN |
denotes |
end |
T5233 |
20634-20636 |
IN |
denotes |
of |
T5234 |
20637-20640 |
DT |
denotes |
the |
T5235 |
20656-20661 |
NN |
denotes |
phase |
T5236 |
20641-20646 |
JJ |
denotes |
first |
T5237 |
20647-20655 |
NN |
denotes |
training |
T5238 |
20662-20665 |
IN |
denotes |
for |
T5239 |
20666-20670 |
NN |
denotes |
odor |
T5240 |
20671-20685 |
NN |
denotes |
discrimination |
T5241 |
20686-20687 |
-LRB- |
denotes |
( |
T5242 |
20687-20698 |
NN |
denotes |
amylacetate |
T5243 |
20699-20705 |
CC |
denotes |
versus |
T5244 |
20706-20719 |
NN |
denotes |
ethylbutyrate |
T5245 |
20719-20720 |
-RRB- |
denotes |
) |
T5246 |
20720-20722 |
, |
denotes |
, |
T5247 |
20722-20725 |
DT |
denotes |
the |
T5248 |
20735-20741 |
NNS |
denotes |
trials |
T5249 |
20726-20734 |
NN |
denotes |
training |
T5250 |
20742-20745 |
IN |
denotes |
for |
T5251 |
20746-20749 |
DT |
denotes |
the |
T5252 |
20761-20765 |
NN |
denotes |
pair |
T5253 |
20750-20755 |
JJ |
denotes |
third |
T5254 |
20756-20760 |
NN |
denotes |
odor |
T5255 |
20766-20767 |
-LRB- |
denotes |
( |
T5256 |
20767-20777 |
JJ |
denotes |
pelargonic |
T5257 |
20793-20797 |
NN |
denotes |
acid |
T5258 |
20778-20784 |
CC |
denotes |
versus |
T5259 |
20785-20792 |
JJ |
denotes |
valeric |
T5260 |
20797-20798 |
-RRB- |
denotes |
) |
T5261 |
20799-20803 |
VBD |
denotes |
were |
T5262 |
20816-20820 |
IN |
denotes |
with |
T5263 |
20821-20831 |
JJ |
denotes |
unrewarded |
T5264 |
20832-20838 |
NNS |
denotes |
trials |
T5265 |
20839-20841 |
IN |
denotes |
in |
T5266 |
20888-20897 |
VBN |
denotes |
presented |
T5267 |
20842-20847 |
WDT |
denotes |
which |
T5268 |
20848-20859 |
NN |
denotes |
amylacetate |
T5269 |
20860-20862 |
CC |
denotes |
or |
T5270 |
20863-20876 |
NN |
denotes |
ethylbutyrate |
T5271 |
20877-20881 |
VBD |
denotes |
were |
T5272 |
20882-20887 |
RB |
denotes |
again |
T5273 |
20898-20899 |
-LRB- |
denotes |
( |
T5274 |
20905-20908 |
NN |
denotes |
bar |
T5275 |
20899-20904 |
JJ |
denotes |
black |
T5276 |
20909-20911 |
IN |
denotes |
in |
T5277 |
20912-20918 |
NN |
denotes |
Figure |
T5278 |
20919-20921 |
NN |
denotes |
2C |
T5279 |
20921-20922 |
-RRB- |
denotes |
) |
T5280 |
20922-20923 |
. |
denotes |
. |
T5281 |
20923-21140 |
sentence |
denotes |
Whereas control mice reliably responded only to the previously rewarded odor (memory of 86 ± 8%, mean ± SD, n = 9, Figure 2E), GluR-BΔFB mice showed reduced olfactory memory (69 ± 16%, n = 9, p < 0.05, Mann-Whitney). |
T5282 |
20924-20931 |
IN |
denotes |
Whereas |
T5283 |
20954-20963 |
VBD |
denotes |
responded |
T5284 |
20932-20939 |
NN |
denotes |
control |
T5285 |
20940-20944 |
NNS |
denotes |
mice |
T5286 |
20945-20953 |
RB |
denotes |
reliably |
T5287 |
21066-21072 |
VBD |
denotes |
showed |
T5288 |
20964-20968 |
RB |
denotes |
only |
T5289 |
20969-20971 |
IN |
denotes |
to |
T5290 |
20972-20975 |
DT |
denotes |
the |
T5291 |
20996-21000 |
NN |
denotes |
odor |
T5292 |
20976-20986 |
RB |
denotes |
previously |
T5293 |
20987-20995 |
VBN |
denotes |
rewarded |
T5294 |
21001-21002 |
-LRB- |
denotes |
( |
T5295 |
21046-21048 |
NN |
denotes |
2E |
T5296 |
21002-21008 |
NN |
denotes |
memory |
T5297 |
21009-21011 |
IN |
denotes |
of |
T5298 |
21012-21014 |
CD |
denotes |
86 |
T5299 |
21017-21018 |
CD |
denotes |
8 |
T5300 |
21015-21016 |
SYM |
denotes |
± |
T5301 |
21018-21019 |
NN |
denotes |
% |
T5302 |
21019-21021 |
, |
denotes |
, |
T5303 |
21021-21025 |
NN |
denotes |
mean |
T5304 |
21028-21030 |
NN |
denotes |
SD |
T5305 |
21026-21027 |
SYM |
denotes |
± |
T5306 |
21030-21032 |
, |
denotes |
, |
T5307 |
21032-21033 |
NN |
denotes |
n |
T5308 |
21036-21037 |
CD |
denotes |
9 |
T5309 |
21034-21035 |
SYM |
denotes |
= |
T5310 |
21037-21039 |
, |
denotes |
, |
T5311 |
21039-21045 |
NN |
denotes |
Figure |
T5312 |
21048-21049 |
-RRB- |
denotes |
) |
T5313 |
21049-21051 |
, |
denotes |
, |
T5314 |
21051-21055 |
NN |
denotes |
GluR |
T5315 |
21056-21060 |
NN |
denotes |
BΔFB |
T5316 |
21055-21056 |
HYPH |
denotes |
- |
T5317 |
21061-21065 |
NNS |
denotes |
mice |
T5318 |
21073-21080 |
VBN |
denotes |
reduced |
T5319 |
21091-21097 |
NN |
denotes |
memory |
T5320 |
21081-21090 |
JJ |
denotes |
olfactory |
T5321 |
21098-21099 |
-LRB- |
denotes |
( |
T5322 |
21131-21138 |
NNP |
denotes |
Whitney |
T5323 |
21099-21101 |
CD |
denotes |
69 |
T5324 |
21104-21106 |
CD |
denotes |
16 |
T5325 |
21102-21103 |
SYM |
denotes |
± |
T5326 |
21106-21107 |
NN |
denotes |
% |
T5327 |
21107-21109 |
, |
denotes |
, |
T5328 |
21109-21110 |
NN |
denotes |
n |
T5329 |
21113-21114 |
CD |
denotes |
9 |
T5330 |
21111-21112 |
SYM |
denotes |
= |
T5331 |
21114-21116 |
, |
denotes |
, |
T5332 |
21116-21117 |
NN |
denotes |
p |
T5333 |
21120-21124 |
CD |
denotes |
0.05 |
T5334 |
21118-21119 |
SYM |
denotes |
< |
T5335 |
21124-21126 |
, |
denotes |
, |
T5336 |
21126-21130 |
NNP |
denotes |
Mann |
T5337 |
21130-21131 |
HYPH |
denotes |
- |
T5338 |
21138-21139 |
-RRB- |
denotes |
) |
T5339 |
21139-21140 |
. |
denotes |
. |
T5340 |
21140-21293 |
sentence |
denotes |
Due to the more rapid learning observed in GluR-BΔFB, one could speculate that a decrease in olfactory memory might simply reflect increased extinction. |
T5341 |
21141-21144 |
IN |
denotes |
Due |
T5342 |
21205-21214 |
VB |
denotes |
speculate |
T5343 |
21145-21147 |
IN |
denotes |
to |
T5344 |
21148-21151 |
DT |
denotes |
the |
T5345 |
21163-21171 |
NN |
denotes |
learning |
T5346 |
21152-21156 |
RBR |
denotes |
more |
T5347 |
21157-21162 |
JJ |
denotes |
rapid |
T5348 |
21172-21180 |
VBN |
denotes |
observed |
T5349 |
21181-21183 |
IN |
denotes |
in |
T5350 |
21184-21188 |
NN |
denotes |
GluR |
T5351 |
21189-21193 |
NN |
denotes |
BΔFB |
T5352 |
21188-21189 |
HYPH |
denotes |
- |
T5353 |
21193-21195 |
, |
denotes |
, |
T5354 |
21195-21198 |
PRP |
denotes |
one |
T5355 |
21199-21204 |
MD |
denotes |
could |
T5356 |
21215-21219 |
IN |
denotes |
that |
T5357 |
21264-21271 |
VB |
denotes |
reflect |
T5358 |
21220-21221 |
DT |
denotes |
a |
T5359 |
21222-21230 |
NN |
denotes |
decrease |
T5360 |
21231-21233 |
IN |
denotes |
in |
T5361 |
21234-21243 |
JJ |
denotes |
olfactory |
T5362 |
21244-21250 |
NN |
denotes |
memory |
T5363 |
21251-21256 |
MD |
denotes |
might |
T5364 |
21257-21263 |
RB |
denotes |
simply |
T5365 |
21272-21281 |
VBN |
denotes |
increased |
T5366 |
21282-21292 |
NN |
denotes |
extinction |
T5367 |
21292-21293 |
. |
denotes |
. |
T5368 |
21293-21566 |
sentence |
denotes |
However, extinction levels were low in general, no significant group-trial interaction could be found for the memory trials (2-way ANOVA, F(6,90) = 1.5, p > 0.1), and a restriction of the analysis to early memory trials displayed essentially the same pattern (Figure S3A). |
T5369 |
21294-21301 |
RB |
denotes |
However |
T5370 |
21321-21325 |
VBD |
denotes |
were |
T5371 |
21301-21303 |
, |
denotes |
, |
T5372 |
21303-21313 |
NN |
denotes |
extinction |
T5373 |
21314-21320 |
NNS |
denotes |
levels |
T5374 |
21326-21329 |
JJ |
denotes |
low |
T5375 |
21330-21332 |
IN |
denotes |
in |
T5376 |
21333-21340 |
JJ |
denotes |
general |
T5377 |
21340-21342 |
, |
denotes |
, |
T5378 |
21342-21344 |
DT |
denotes |
no |
T5379 |
21369-21380 |
NN |
denotes |
interaction |
T5380 |
21345-21356 |
JJ |
denotes |
significant |
T5381 |
21357-21362 |
NN |
denotes |
group |
T5382 |
21363-21368 |
NN |
denotes |
trial |
T5383 |
21362-21363 |
SYM |
denotes |
- |
T5384 |
21390-21395 |
VBN |
denotes |
found |
T5385 |
21381-21386 |
MD |
denotes |
could |
T5386 |
21387-21389 |
VB |
denotes |
be |
T5387 |
21396-21399 |
IN |
denotes |
for |
T5388 |
21400-21403 |
DT |
denotes |
the |
T5389 |
21411-21417 |
NNS |
denotes |
trials |
T5390 |
21404-21410 |
NN |
denotes |
memory |
T5391 |
21418-21419 |
-LRB- |
denotes |
( |
T5392 |
21425-21430 |
NN |
denotes |
ANOVA |
T5393 |
21419-21420 |
CD |
denotes |
2 |
T5394 |
21421-21424 |
NN |
denotes |
way |
T5395 |
21420-21421 |
HYPH |
denotes |
- |
T5396 |
21430-21432 |
, |
denotes |
, |
T5397 |
21432-21433 |
NN |
denotes |
F |
T5398 |
21442-21445 |
CD |
denotes |
1.5 |
T5399 |
21433-21434 |
-LRB- |
denotes |
( |
T5400 |
21434-21435 |
CD |
denotes |
6 |
T5401 |
21435-21436 |
, |
denotes |
, |
T5402 |
21436-21438 |
CD |
denotes |
90 |
T5403 |
21438-21439 |
-RRB- |
denotes |
) |
T5404 |
21440-21441 |
SYM |
denotes |
= |
T5405 |
21445-21447 |
, |
denotes |
, |
T5406 |
21447-21448 |
NN |
denotes |
p |
T5407 |
21451-21454 |
CD |
denotes |
0.1 |
T5408 |
21449-21450 |
SYM |
denotes |
> |
T5409 |
21454-21455 |
-RRB- |
denotes |
) |
T5410 |
21455-21457 |
, |
denotes |
, |
T5411 |
21457-21460 |
CC |
denotes |
and |
T5412 |
21461-21462 |
DT |
denotes |
a |
T5413 |
21463-21474 |
NN |
denotes |
restriction |
T5414 |
21514-21523 |
VBD |
denotes |
displayed |
T5415 |
21475-21477 |
IN |
denotes |
of |
T5416 |
21478-21481 |
DT |
denotes |
the |
T5417 |
21482-21490 |
NN |
denotes |
analysis |
T5418 |
21491-21493 |
IN |
denotes |
to |
T5419 |
21494-21499 |
JJ |
denotes |
early |
T5420 |
21507-21513 |
NNS |
denotes |
trials |
T5421 |
21500-21506 |
NN |
denotes |
memory |
T5422 |
21524-21535 |
RB |
denotes |
essentially |
T5423 |
21545-21552 |
NN |
denotes |
pattern |
T5424 |
21536-21539 |
DT |
denotes |
the |
T5425 |
21540-21544 |
JJ |
denotes |
same |
T5426 |
21553-21554 |
-LRB- |
denotes |
( |
T5427 |
21561-21564 |
NN |
denotes |
S3A |
T5428 |
21554-21560 |
NN |
denotes |
Figure |
T5429 |
21564-21565 |
-RRB- |
denotes |
) |
T5430 |
21565-21566 |
. |
denotes |
. |
T5431 |
21566-21687 |
sentence |
denotes |
Thus, reduced performance in the probe trials is not due to increased extinction but reflects genuine memory impairment. |
T5432 |
21567-21571 |
RB |
denotes |
Thus |
T5433 |
21613-21615 |
VBZ |
denotes |
is |
T5434 |
21571-21573 |
, |
denotes |
, |
T5435 |
21573-21580 |
VBN |
denotes |
reduced |
T5436 |
21581-21592 |
NN |
denotes |
performance |
T5437 |
21593-21595 |
IN |
denotes |
in |
T5438 |
21596-21599 |
DT |
denotes |
the |
T5439 |
21606-21612 |
NNS |
denotes |
trials |
T5440 |
21600-21605 |
NN |
denotes |
probe |
T5441 |
21616-21619 |
RB |
denotes |
not |
T5442 |
21620-21623 |
IN |
denotes |
due |
T5443 |
21624-21626 |
IN |
denotes |
to |
T5444 |
21627-21636 |
VBN |
denotes |
increased |
T5445 |
21637-21647 |
NN |
denotes |
extinction |
T5446 |
21648-21651 |
CC |
denotes |
but |
T5447 |
21652-21660 |
VBZ |
denotes |
reflects |
T5448 |
21661-21668 |
JJ |
denotes |
genuine |
T5449 |
21676-21686 |
NN |
denotes |
impairment |
T5450 |
21669-21675 |
NN |
denotes |
memory |
T5451 |
21686-21687 |
. |
denotes |
. |
T5452 |
21687-21954 |
sentence |
denotes |
Moreover, because the hippocampus-dependent spatial memory after-task acquisition in the Y-maze was not affected (Figure S2), we conclude that the observed olfactory memory deficit is rather specific for olfaction and does not readily generalize to other modalities. |
T5453 |
21688-21696 |
RB |
denotes |
Moreover |
T5454 |
21817-21825 |
VBP |
denotes |
conclude |
T5455 |
21696-21698 |
, |
denotes |
, |
T5456 |
21698-21705 |
IN |
denotes |
because |
T5457 |
21792-21800 |
VBN |
denotes |
affected |
T5458 |
21706-21709 |
DT |
denotes |
the |
T5459 |
21758-21769 |
NN |
denotes |
acquisition |
T5460 |
21710-21721 |
NN |
denotes |
hippocampus |
T5461 |
21722-21731 |
JJ |
denotes |
dependent |
T5462 |
21721-21722 |
HYPH |
denotes |
- |
T5463 |
21732-21739 |
JJ |
denotes |
spatial |
T5464 |
21740-21746 |
NN |
denotes |
memory |
T5465 |
21747-21752 |
IN |
denotes |
after |
T5466 |
21753-21757 |
NN |
denotes |
task |
T5467 |
21752-21753 |
HYPH |
denotes |
- |
T5468 |
21770-21772 |
IN |
denotes |
in |
T5469 |
21773-21776 |
DT |
denotes |
the |
T5470 |
21779-21783 |
NN |
denotes |
maze |
T5471 |
21777-21778 |
NN |
denotes |
Y |
T5472 |
21778-21779 |
HYPH |
denotes |
- |
T5473 |
21784-21787 |
VBD |
denotes |
was |
T5474 |
21788-21791 |
RB |
denotes |
not |
T5475 |
21801-21802 |
-LRB- |
denotes |
( |
T5476 |
21809-21811 |
NN |
denotes |
S2 |
T5477 |
21802-21808 |
NN |
denotes |
Figure |
T5478 |
21811-21812 |
-RRB- |
denotes |
) |
T5479 |
21812-21814 |
, |
denotes |
, |
T5480 |
21814-21816 |
PRP |
denotes |
we |
T5481 |
21826-21830 |
IN |
denotes |
that |
T5482 |
21869-21871 |
VBZ |
denotes |
is |
T5483 |
21831-21834 |
DT |
denotes |
the |
T5484 |
21861-21868 |
NN |
denotes |
deficit |
T5485 |
21835-21843 |
VBN |
denotes |
observed |
T5486 |
21844-21853 |
JJ |
denotes |
olfactory |
T5487 |
21854-21860 |
NN |
denotes |
memory |
T5488 |
21872-21878 |
RB |
denotes |
rather |
T5489 |
21879-21887 |
JJ |
denotes |
specific |
T5490 |
21888-21891 |
IN |
denotes |
for |
T5491 |
21892-21901 |
NN |
denotes |
olfaction |
T5492 |
21902-21905 |
CC |
denotes |
and |
T5493 |
21906-21910 |
VBZ |
denotes |
does |
T5494 |
21923-21933 |
VB |
denotes |
generalize |
T5495 |
21911-21914 |
RB |
denotes |
not |
T5496 |
21915-21922 |
RB |
denotes |
readily |
T5497 |
21934-21936 |
IN |
denotes |
to |
T5498 |
21937-21942 |
JJ |
denotes |
other |
T5499 |
21943-21953 |
NNS |
denotes |
modalities |
T5500 |
21953-21954 |
. |
denotes |
. |
T5501 |
21954-22212 |
sentence |
denotes |
While the improved odor discrimination and learning behavior showed only little variability, the significantly impaired memory performance observed in GluR-BΔFB mice was highly variable among individual animals compared with control littermates (Figure 2E). |
T5502 |
21955-21960 |
IN |
denotes |
While |
T5503 |
22016-22022 |
VBD |
denotes |
showed |
T5504 |
21961-21964 |
DT |
denotes |
the |
T5505 |
22007-22015 |
NN |
denotes |
behavior |
T5506 |
21965-21973 |
VBN |
denotes |
improved |
T5507 |
21974-21978 |
NN |
denotes |
odor |
T5508 |
21979-21993 |
NN |
denotes |
discrimination |
T5509 |
21994-21997 |
CC |
denotes |
and |
T5510 |
21998-22006 |
NN |
denotes |
learning |
T5511 |
22121-22124 |
VBD |
denotes |
was |
T5512 |
22023-22027 |
RB |
denotes |
only |
T5513 |
22035-22046 |
NN |
denotes |
variability |
T5514 |
22028-22034 |
JJ |
denotes |
little |
T5515 |
22046-22048 |
, |
denotes |
, |
T5516 |
22048-22051 |
DT |
denotes |
the |
T5517 |
22082-22093 |
NN |
denotes |
performance |
T5518 |
22052-22065 |
RB |
denotes |
significantly |
T5519 |
22066-22074 |
VBN |
denotes |
impaired |
T5520 |
22075-22081 |
NN |
denotes |
memory |
T5521 |
22094-22102 |
VBN |
denotes |
observed |
T5522 |
22103-22105 |
IN |
denotes |
in |
T5523 |
22106-22110 |
NN |
denotes |
GluR |
T5524 |
22111-22115 |
NN |
denotes |
BΔFB |
T5525 |
22110-22111 |
HYPH |
denotes |
- |
T5526 |
22116-22120 |
NNS |
denotes |
mice |
T5527 |
22125-22131 |
RB |
denotes |
highly |
T5528 |
22132-22140 |
JJ |
denotes |
variable |
T5529 |
22141-22146 |
IN |
denotes |
among |
T5530 |
22147-22157 |
JJ |
denotes |
individual |
T5531 |
22158-22165 |
NNS |
denotes |
animals |
T5532 |
22166-22174 |
VBN |
denotes |
compared |
T5533 |
22175-22179 |
IN |
denotes |
with |
T5534 |
22180-22187 |
NN |
denotes |
control |
T5535 |
22188-22199 |
NNS |
denotes |
littermates |
T5536 |
22200-22201 |
-LRB- |
denotes |
( |
T5537 |
22208-22210 |
NN |
denotes |
2E |
T5538 |
22201-22207 |
NN |
denotes |
Figure |
T5539 |
22210-22211 |
-RRB- |
denotes |
) |
T5540 |
22211-22212 |
. |
denotes |
. |
T5541 |
22212-22425 |
sentence |
denotes |
This variability in olfactory memory was reflected in the level and extent of Cre-recombinase expression in forebrain of transgenic TgCre4 mice, as visualized by Cre-activity in the Cre-indicator mouse line R26R. |
T5542 |
22213-22217 |
DT |
denotes |
This |
T5543 |
22218-22229 |
NN |
denotes |
variability |
T5544 |
22254-22263 |
VBN |
denotes |
reflected |
T5545 |
22230-22232 |
IN |
denotes |
in |
T5546 |
22233-22242 |
JJ |
denotes |
olfactory |
T5547 |
22243-22249 |
NN |
denotes |
memory |
T5548 |
22250-22253 |
VBD |
denotes |
was |
T5549 |
22264-22266 |
IN |
denotes |
in |
T5550 |
22267-22270 |
DT |
denotes |
the |
T5551 |
22271-22276 |
NN |
denotes |
level |
T5552 |
22277-22280 |
CC |
denotes |
and |
T5553 |
22281-22287 |
NN |
denotes |
extent |
T5554 |
22288-22290 |
IN |
denotes |
of |
T5555 |
22291-22294 |
NN |
denotes |
Cre |
T5556 |
22295-22306 |
NN |
denotes |
recombinase |
T5557 |
22294-22295 |
HYPH |
denotes |
- |
T5558 |
22307-22317 |
NN |
denotes |
expression |
T5559 |
22318-22320 |
IN |
denotes |
in |
T5560 |
22321-22330 |
NN |
denotes |
forebrain |
T5561 |
22331-22333 |
IN |
denotes |
of |
T5562 |
22334-22344 |
JJ |
denotes |
transgenic |
T5563 |
22352-22356 |
NNS |
denotes |
mice |
T5564 |
22345-22351 |
NN |
denotes |
TgCre4 |
T5565 |
22356-22358 |
, |
denotes |
, |
T5566 |
22358-22360 |
IN |
denotes |
as |
T5567 |
22361-22371 |
VBN |
denotes |
visualized |
T5568 |
22372-22374 |
IN |
denotes |
by |
T5569 |
22375-22378 |
NN |
denotes |
Cre |
T5570 |
22379-22387 |
NN |
denotes |
activity |
T5571 |
22378-22379 |
HYPH |
denotes |
- |
T5572 |
22388-22390 |
IN |
denotes |
in |
T5573 |
22391-22394 |
DT |
denotes |
the |
T5574 |
22415-22419 |
NN |
denotes |
line |
T5575 |
22395-22398 |
NN |
denotes |
Cre |
T5576 |
22399-22408 |
NN |
denotes |
indicator |
T5577 |
22398-22399 |
HYPH |
denotes |
- |
T5578 |
22409-22414 |
NN |
denotes |
mouse |
T5579 |
22420-22424 |
NN |
denotes |
R26R |
T5580 |
22424-22425 |
. |
denotes |
. |
T5581 |
22425-22673 |
sentence |
denotes |
We observed that onset and extent of Cre-recombinase expression in different forebrain regions varied among individual TgCre4 mice (Figure 3A), which could also be directly visualized by immunohistochemistry with a Cre-antibody (unpublished data). |
T5582 |
22426-22428 |
PRP |
denotes |
We |
T5583 |
22429-22437 |
VBD |
denotes |
observed |
T5584 |
22438-22442 |
IN |
denotes |
that |
T5585 |
22521-22527 |
VBD |
denotes |
varied |
T5586 |
22443-22448 |
NN |
denotes |
onset |
T5587 |
22449-22452 |
CC |
denotes |
and |
T5588 |
22453-22459 |
NN |
denotes |
extent |
T5589 |
22460-22462 |
IN |
denotes |
of |
T5590 |
22463-22466 |
NN |
denotes |
Cre |
T5591 |
22467-22478 |
NN |
denotes |
recombinase |
T5592 |
22466-22467 |
HYPH |
denotes |
- |
T5593 |
22479-22489 |
NN |
denotes |
expression |
T5594 |
22490-22492 |
IN |
denotes |
in |
T5595 |
22493-22502 |
JJ |
denotes |
different |
T5596 |
22513-22520 |
NNS |
denotes |
regions |
T5597 |
22503-22512 |
NN |
denotes |
forebrain |
T5598 |
22528-22533 |
IN |
denotes |
among |
T5599 |
22534-22544 |
JJ |
denotes |
individual |
T5600 |
22552-22556 |
NNS |
denotes |
mice |
T5601 |
22545-22551 |
NN |
denotes |
TgCre4 |
T5602 |
22557-22558 |
-LRB- |
denotes |
( |
T5603 |
22565-22567 |
NN |
denotes |
3A |
T5604 |
22558-22564 |
NN |
denotes |
Figure |
T5605 |
22567-22568 |
-RRB- |
denotes |
) |
T5606 |
22568-22570 |
, |
denotes |
, |
T5607 |
22570-22575 |
WDT |
denotes |
which |
T5608 |
22599-22609 |
VBN |
denotes |
visualized |
T5609 |
22576-22581 |
MD |
denotes |
could |
T5610 |
22582-22586 |
RB |
denotes |
also |
T5611 |
22587-22589 |
VB |
denotes |
be |
T5612 |
22590-22598 |
RB |
denotes |
directly |
T5613 |
22610-22612 |
IN |
denotes |
by |
T5614 |
22613-22633 |
NN |
denotes |
immunohistochemistry |
T5615 |
22634-22638 |
IN |
denotes |
with |
T5616 |
22639-22640 |
DT |
denotes |
a |
T5617 |
22645-22653 |
NN |
denotes |
antibody |
T5618 |
22641-22644 |
NN |
denotes |
Cre |
T5619 |
22644-22645 |
HYPH |
denotes |
- |
T5620 |
22654-22655 |
-LRB- |
denotes |
( |
T5621 |
22667-22671 |
NNS |
denotes |
data |
T5622 |
22655-22666 |
JJ |
denotes |
unpublished |
T5623 |
22671-22672 |
-RRB- |
denotes |
) |
T5624 |
22672-22673 |
. |
denotes |
. |
T5625 |
22673-22930 |
sentence |
denotes |
As this variability persisted after several backcrosses, and Southern blot analysis revealed no differences of transgene integration or number among animals (Figure 3B), it could not be attributed to genetic differences but rather to epigenetic mechanisms. |
T5626 |
22674-22676 |
IN |
denotes |
As |
T5627 |
22694-22703 |
VBD |
denotes |
persisted |
T5628 |
22677-22681 |
DT |
denotes |
this |
T5629 |
22682-22693 |
NN |
denotes |
variability |
T5630 |
22860-22870 |
VBN |
denotes |
attributed |
T5631 |
22704-22709 |
IN |
denotes |
after |
T5632 |
22710-22717 |
JJ |
denotes |
several |
T5633 |
22718-22729 |
NNS |
denotes |
backcrosses |
T5634 |
22729-22731 |
, |
denotes |
, |
T5635 |
22731-22734 |
CC |
denotes |
and |
T5636 |
22735-22743 |
NNP |
denotes |
Southern |
T5637 |
22744-22748 |
NN |
denotes |
blot |
T5638 |
22749-22757 |
NN |
denotes |
analysis |
T5639 |
22758-22766 |
VBD |
denotes |
revealed |
T5640 |
22767-22769 |
DT |
denotes |
no |
T5641 |
22770-22781 |
NNS |
denotes |
differences |
T5642 |
22782-22784 |
IN |
denotes |
of |
T5643 |
22785-22794 |
NN |
denotes |
transgene |
T5644 |
22795-22806 |
NN |
denotes |
integration |
T5645 |
22807-22809 |
CC |
denotes |
or |
T5646 |
22810-22816 |
NN |
denotes |
number |
T5647 |
22817-22822 |
IN |
denotes |
among |
T5648 |
22823-22830 |
NNS |
denotes |
animals |
T5649 |
22831-22832 |
-LRB- |
denotes |
( |
T5650 |
22839-22841 |
NN |
denotes |
3B |
T5651 |
22832-22838 |
NN |
denotes |
Figure |
T5652 |
22841-22842 |
-RRB- |
denotes |
) |
T5653 |
22842-22844 |
, |
denotes |
, |
T5654 |
22844-22846 |
PRP |
denotes |
it |
T5655 |
22847-22852 |
MD |
denotes |
could |
T5656 |
22853-22856 |
RB |
denotes |
not |
T5657 |
22857-22859 |
VB |
denotes |
be |
T5658 |
22871-22873 |
IN |
denotes |
to |
T5659 |
22874-22881 |
JJ |
denotes |
genetic |
T5660 |
22882-22893 |
NNS |
denotes |
differences |
T5661 |
22894-22897 |
CC |
denotes |
but |
T5662 |
22898-22904 |
RB |
denotes |
rather |
T5663 |
22905-22907 |
IN |
denotes |
to |
T5664 |
22908-22918 |
JJ |
denotes |
epigenetic |
T5665 |
22919-22929 |
NNS |
denotes |
mechanisms |
T5666 |
22929-22930 |
. |
denotes |
. |
T5667 |
22930-23625 |
sentence |
denotes |
Figure 3 Variability of Cre Expression of Mouse Line TgCre4
(A) Variable Cre expression in forebrains of three different mice positive for TgCre4 and R26R Cre indicator (see Figure S1) at postnatal day 12 pictured by the Cre-dependent β-galactosidase activity (blue, X-gal, counterstain by eosin) in coronal brain slices. Scale bar: 1.25 mm.
(B) Southern blot analysis of BglII-digested genomic mouse DNA of four TgCre4 mice that differed in the Cre expression pattern. Southern probe detects the wild-type (4.5 kbp) and the transgenic (7, 5, 3, and 2 kbp) alleles. Hence, we hypothesized that the variability in olfactory memory reflected the mosaicism observed in the transgenic TgCre4 line. |
T5668 |
23498-23503 |
RB |
denotes |
Hence |
T5669 |
23508-23520 |
VBD |
denotes |
hypothesized |
T5670 |
23503-23505 |
, |
denotes |
, |
T5671 |
23505-23507 |
PRP |
denotes |
we |
T5672 |
23521-23525 |
IN |
denotes |
that |
T5673 |
23562-23571 |
VBD |
denotes |
reflected |
T5674 |
23526-23529 |
DT |
denotes |
the |
T5675 |
23530-23541 |
NN |
denotes |
variability |
T5676 |
23542-23544 |
IN |
denotes |
in |
T5677 |
23545-23554 |
JJ |
denotes |
olfactory |
T5678 |
23555-23561 |
NN |
denotes |
memory |
T5679 |
23572-23575 |
DT |
denotes |
the |
T5680 |
23576-23585 |
NN |
denotes |
mosaicism |
T5681 |
23586-23594 |
VBN |
denotes |
observed |
T5682 |
23595-23597 |
IN |
denotes |
in |
T5683 |
23598-23601 |
DT |
denotes |
the |
T5684 |
23620-23624 |
NN |
denotes |
line |
T5685 |
23602-23612 |
JJ |
denotes |
transgenic |
T5686 |
23613-23619 |
NN |
denotes |
TgCre4 |
T5687 |
23624-23625 |
. |
denotes |
. |
T5688 |
23625-23822 |
sentence |
denotes |
The evaluation of regional differences in expression pattern of animals with robust and poor olfactory memory could then be applied to identify brain areas responsible for the observed phenotypes. |
T5689 |
23626-23629 |
DT |
denotes |
The |
T5690 |
23630-23640 |
NN |
denotes |
evaluation |
T5691 |
23750-23757 |
VBN |
denotes |
applied |
T5692 |
23641-23643 |
IN |
denotes |
of |
T5693 |
23644-23652 |
JJ |
denotes |
regional |
T5694 |
23653-23664 |
NNS |
denotes |
differences |
T5695 |
23665-23667 |
IN |
denotes |
in |
T5696 |
23668-23678 |
NN |
denotes |
expression |
T5697 |
23679-23686 |
NN |
denotes |
pattern |
T5698 |
23687-23689 |
IN |
denotes |
of |
T5699 |
23690-23697 |
NNS |
denotes |
animals |
T5700 |
23698-23702 |
IN |
denotes |
with |
T5701 |
23703-23709 |
JJ |
denotes |
robust |
T5702 |
23729-23735 |
NN |
denotes |
memory |
T5703 |
23710-23713 |
CC |
denotes |
and |
T5704 |
23714-23718 |
JJ |
denotes |
poor |
T5705 |
23719-23728 |
JJ |
denotes |
olfactory |
T5706 |
23736-23741 |
MD |
denotes |
could |
T5707 |
23742-23746 |
RB |
denotes |
then |
T5708 |
23747-23749 |
VB |
denotes |
be |
T5709 |
23758-23760 |
TO |
denotes |
to |
T5710 |
23761-23769 |
VB |
denotes |
identify |
T5711 |
23770-23775 |
NN |
denotes |
brain |
T5712 |
23776-23781 |
NNS |
denotes |
areas |
T5713 |
23782-23793 |
JJ |
denotes |
responsible |
T5714 |
23794-23797 |
IN |
denotes |
for |
T5715 |
23798-23801 |
DT |
denotes |
the |
T5716 |
23811-23821 |
NNS |
denotes |
phenotypes |
T5717 |
23802-23810 |
VBN |
denotes |
observed |
T5718 |
23821-23822 |
. |
denotes |
. |
T5967 |
23824-23833 |
JJ |
denotes |
Olfactory |
T5968 |
23834-23840 |
NN |
denotes |
Memory |
T5969 |
23841-23851 |
VBZ |
denotes |
Correlates |
T5970 |
23852-23856 |
IN |
denotes |
with |
T5971 |
23857-23865 |
JJ |
denotes |
Residual |
T5972 |
23881-23891 |
NN |
denotes |
Expression |
T5973 |
23866-23870 |
NN |
denotes |
GluR |
T5974 |
23871-23872 |
NN |
denotes |
B |
T5975 |
23870-23871 |
HYPH |
denotes |
- |
T5976 |
23873-23880 |
NN |
denotes |
Protein |
T5977 |
23892-23894 |
IN |
denotes |
in |
T5978 |
23895-23899 |
NN |
denotes |
GluR |
T5979 |
23900-23904 |
NN |
denotes |
BΔFB |
T5980 |
23899-23900 |
HYPH |
denotes |
- |
T5981 |
23905-23909 |
NNS |
denotes |
Mice |
T5982 |
23909-24176 |
sentence |
denotes |
Thus, to examine whether the pronounced variability of olfactory memory in GluR-BΔFB mice (Figure 2E) reflects variability of GluR-B levels in GluR-BΔFB mice, we analyzed the residual amount of GluR-B protein in mice with disparate memory performances (Figure 4A–C). |
T5983 |
23910-23914 |
RB |
denotes |
Thus |
T5984 |
24072-24080 |
VBD |
denotes |
analyzed |
T5985 |
23914-23916 |
, |
denotes |
, |
T5986 |
23916-23918 |
TO |
denotes |
to |
T5987 |
23919-23926 |
VB |
denotes |
examine |
T5988 |
23927-23934 |
IN |
denotes |
whether |
T5989 |
24012-24020 |
VBZ |
denotes |
reflects |
T5990 |
23935-23938 |
DT |
denotes |
the |
T5991 |
23950-23961 |
NN |
denotes |
variability |
T5992 |
23939-23949 |
JJ |
denotes |
pronounced |
T5993 |
23962-23964 |
IN |
denotes |
of |
T5994 |
23965-23974 |
JJ |
denotes |
olfactory |
T5995 |
23975-23981 |
NN |
denotes |
memory |
T5996 |
23982-23984 |
IN |
denotes |
in |
T5997 |
23985-23989 |
NN |
denotes |
GluR |
T5998 |
23990-23994 |
NN |
denotes |
BΔFB |
T5999 |
23989-23990 |
HYPH |
denotes |
- |
T6000 |
23995-23999 |
NNS |
denotes |
mice |
T6001 |
24000-24001 |
-LRB- |
denotes |
( |
T6002 |
24008-24010 |
NN |
denotes |
2E |
T6003 |
24001-24007 |
NN |
denotes |
Figure |
T6004 |
24010-24011 |
-RRB- |
denotes |
) |
T6005 |
24021-24032 |
NN |
denotes |
variability |
T6006 |
24033-24035 |
IN |
denotes |
of |
T6007 |
24036-24040 |
NN |
denotes |
GluR |
T6008 |
24041-24042 |
NN |
denotes |
B |
T6009 |
24040-24041 |
HYPH |
denotes |
- |
T6010 |
24043-24049 |
NNS |
denotes |
levels |
T6011 |
24050-24052 |
IN |
denotes |
in |
T6012 |
24053-24057 |
NN |
denotes |
GluR |
T6013 |
24058-24062 |
NN |
denotes |
BΔFB |
T6014 |
24057-24058 |
HYPH |
denotes |
- |
T6015 |
24063-24067 |
NNS |
denotes |
mice |
T6016 |
24067-24069 |
, |
denotes |
, |
T6017 |
24069-24071 |
PRP |
denotes |
we |
T6018 |
24081-24084 |
DT |
denotes |
the |
T6019 |
24094-24100 |
NN |
denotes |
amount |
T6020 |
24085-24093 |
JJ |
denotes |
residual |
T6021 |
24101-24103 |
IN |
denotes |
of |
T6022 |
24104-24108 |
NN |
denotes |
GluR |
T6023 |
24109-24110 |
NN |
denotes |
B |
T6024 |
24108-24109 |
HYPH |
denotes |
- |
T6025 |
24111-24118 |
NN |
denotes |
protein |
T6026 |
24119-24121 |
IN |
denotes |
in |
T6027 |
24122-24126 |
NNS |
denotes |
mice |
T6028 |
24127-24131 |
IN |
denotes |
with |
T6029 |
24132-24141 |
JJ |
denotes |
disparate |
T6030 |
24149-24161 |
NNS |
denotes |
performances |
T6031 |
24142-24148 |
NN |
denotes |
memory |
T6032 |
24162-24163 |
-LRB- |
denotes |
( |
T6033 |
24170-24172 |
NN |
denotes |
4A |
T6034 |
24163-24169 |
NN |
denotes |
Figure |
T6035 |
24172-24173 |
SYM |
denotes |
– |
T6036 |
24173-24174 |
NN |
denotes |
C |
T6037 |
24174-24175 |
-RRB- |
denotes |
) |
T6038 |
24175-24176 |
. |
denotes |
. |
T6039 |
24176-24545 |
sentence |
denotes |
Notably, mice with pronounced memory deficits (memory < 70%) showed essentially no detectable GluR-B protein in hippocampus, amygdala, olfactory bulb, and piriform cortex (n = 2, Figure 4B, and unpublished data), but mice with almost complete memory displayed substantial residual GluR-B levels in all brain areas investigated (n = 2, Figure 4B, and unpublished data). |
T6040 |
24177-24184 |
RB |
denotes |
Notably |
T6041 |
24238-24244 |
VBD |
denotes |
showed |
T6042 |
24184-24186 |
, |
denotes |
, |
T6043 |
24186-24190 |
NNS |
denotes |
mice |
T6044 |
24191-24195 |
IN |
denotes |
with |
T6045 |
24196-24206 |
JJ |
denotes |
pronounced |
T6046 |
24214-24222 |
NNS |
denotes |
deficits |
T6047 |
24207-24213 |
NN |
denotes |
memory |
T6048 |
24223-24224 |
-LRB- |
denotes |
( |
T6049 |
24235-24236 |
NN |
denotes |
% |
T6050 |
24224-24230 |
NN |
denotes |
memory |
T6051 |
24231-24232 |
SYM |
denotes |
< |
T6052 |
24233-24235 |
CD |
denotes |
70 |
T6053 |
24236-24237 |
-RRB- |
denotes |
) |
T6054 |
24245-24256 |
RB |
denotes |
essentially |
T6055 |
24278-24285 |
NN |
denotes |
protein |
T6056 |
24257-24259 |
DT |
denotes |
no |
T6057 |
24260-24270 |
JJ |
denotes |
detectable |
T6058 |
24271-24275 |
NN |
denotes |
GluR |
T6059 |
24276-24277 |
NN |
denotes |
B |
T6060 |
24275-24276 |
HYPH |
denotes |
- |
T6061 |
24286-24288 |
IN |
denotes |
in |
T6062 |
24289-24300 |
NN |
denotes |
hippocampus |
T6063 |
24300-24302 |
, |
denotes |
, |
T6064 |
24302-24310 |
NN |
denotes |
amygdala |
T6065 |
24310-24312 |
, |
denotes |
, |
T6066 |
24312-24321 |
JJ |
denotes |
olfactory |
T6067 |
24322-24326 |
NN |
denotes |
bulb |
T6068 |
24326-24328 |
, |
denotes |
, |
T6069 |
24328-24331 |
CC |
denotes |
and |
T6070 |
24332-24340 |
JJ |
denotes |
piriform |
T6071 |
24341-24347 |
NN |
denotes |
cortex |
T6072 |
24348-24349 |
-LRB- |
denotes |
( |
T6073 |
24363-24365 |
NN |
denotes |
4B |
T6074 |
24349-24350 |
NN |
denotes |
n |
T6075 |
24353-24354 |
CD |
denotes |
2 |
T6076 |
24351-24352 |
SYM |
denotes |
= |
T6077 |
24354-24356 |
, |
denotes |
, |
T6078 |
24356-24362 |
NN |
denotes |
Figure |
T6079 |
24365-24367 |
, |
denotes |
, |
T6080 |
24367-24370 |
CC |
denotes |
and |
T6081 |
24371-24382 |
JJ |
denotes |
unpublished |
T6082 |
24383-24387 |
NNS |
denotes |
data |
T6083 |
24387-24388 |
-RRB- |
denotes |
) |
T6084 |
24388-24390 |
, |
denotes |
, |
T6085 |
24390-24393 |
CC |
denotes |
but |
T6086 |
24394-24398 |
NNS |
denotes |
mice |
T6087 |
24427-24436 |
VBD |
denotes |
displayed |
T6088 |
24399-24403 |
IN |
denotes |
with |
T6089 |
24404-24410 |
RB |
denotes |
almost |
T6090 |
24411-24419 |
JJ |
denotes |
complete |
T6091 |
24420-24426 |
NN |
denotes |
memory |
T6092 |
24437-24448 |
JJ |
denotes |
substantial |
T6093 |
24465-24471 |
NNS |
denotes |
levels |
T6094 |
24449-24457 |
JJ |
denotes |
residual |
T6095 |
24458-24462 |
NN |
denotes |
GluR |
T6096 |
24463-24464 |
NN |
denotes |
B |
T6097 |
24462-24463 |
HYPH |
denotes |
- |
T6098 |
24472-24474 |
IN |
denotes |
in |
T6099 |
24475-24478 |
DT |
denotes |
all |
T6100 |
24485-24490 |
NNS |
denotes |
areas |
T6101 |
24479-24484 |
NN |
denotes |
brain |
T6102 |
24491-24503 |
VBN |
denotes |
investigated |
T6103 |
24504-24505 |
-LRB- |
denotes |
( |
T6104 |
24519-24521 |
NN |
denotes |
4B |
T6105 |
24505-24506 |
NN |
denotes |
n |
T6106 |
24509-24510 |
CD |
denotes |
2 |
T6107 |
24507-24508 |
SYM |
denotes |
= |
T6108 |
24510-24512 |
, |
denotes |
, |
T6109 |
24512-24518 |
NN |
denotes |
Figure |
T6110 |
24521-24523 |
, |
denotes |
, |
T6111 |
24523-24526 |
CC |
denotes |
and |
T6112 |
24527-24538 |
JJ |
denotes |
unpublished |
T6113 |
24539-24543 |
NNS |
denotes |
data |
T6114 |
24543-24544 |
-RRB- |
denotes |
) |
T6115 |
24544-24545 |
. |
denotes |
. |
T6116 |
24545-26944 |
sentence |
denotes |
Figure 4 Olfactory Memory but not Odor Learning/Discrimination Is Correlated with Residual GluR-B Levels in Hippocampus and Forebrain of GluR-BΔFB Mice
(A) The olfactory memory performance for 18 GluR-BΔFB (red) and 11 littermate control (black) mice is given as mean (thick lines ± SEM) and as individual performance in open circles and triangles. Arrows with numbers (#) indicate those mice used in experiments (B–C). Data were combined from Figure 2 (open symbols) and an additional experiment with nine GluR-BΔFB and two littermate controls (shaded symbols).
(B and C) Residual GluR-B levels as detected by anti-GluR-B immunofluorescence in hippocampus, amygdala, piriform cortex, and olfactory bulb of one control (#1) and two GluR-BΔFB (#2 and #3) coronal mouse brain sections (B) and by immunoblot analysis from hippocampal (Hip), cortical forebrain (FB), and olfactory bulb (OB) protein extracts of control (#4) and GluR-BΔFB mice (#5, #6, #7, and #8) probed with antibodies detecting GluR-B and β-actin as an internal loading control (C). Scale bars: 200 μm (first panel), 100 μm (other panels).
(D) From ten GluR-BΔFB mice, the individual odor learning/discrimination and olfactory memory performance was determined together with the relative GluR-B levels in immunoblots of hippocampal, forebrain, and olfactory bulb protein extracts. Memory performance (top panels) and discrimination capability (bottom panels; discrimination index is measured for the last 100 trials of the mixture discrimination task as indicated by the arrow in Figure 2C) were plotted against GluR-B levels. Memory was tightly correlated to GluR-B protein level in hippocampus (R2 = 0.72; p < 0.003) and cortical forebrain (R2 = 0.62; p < 0.006) and only weakly in the olfactory bulb (R2 = 0.48; p = 0.03). No measure of learning/discrimination (discrimination index for last 100 mixture trials [D], slopes of trend lines, average discrimination index, average sampling pattern differences, correct performance, etc. [not shown]) displayed any correlation (R2 < 0.3). To quantify the relation between residual GluR-B protein and olfactory memory, the memory experiment was repeated with nine additional GluR-BΔFB mice and two GluR-B2lox control animals (indicated with shaded symbols in Figure 4A), resulting in the same mean, variability, and range of memory performance (control: 89 ± 10%; GluR-BΔFB: 63 ± 14%). |
T6117 |
26599-26601 |
TO |
denotes |
To |
T6118 |
26602-26610 |
VB |
denotes |
quantify |
T6119 |
26704-26712 |
VBN |
denotes |
repeated |
T6120 |
26611-26614 |
DT |
denotes |
the |
T6121 |
26615-26623 |
NN |
denotes |
relation |
T6122 |
26624-26631 |
IN |
denotes |
between |
T6123 |
26632-26640 |
JJ |
denotes |
residual |
T6124 |
26648-26655 |
NN |
denotes |
protein |
T6125 |
26641-26645 |
NN |
denotes |
GluR |
T6126 |
26646-26647 |
NN |
denotes |
B |
T6127 |
26645-26646 |
HYPH |
denotes |
- |
T6128 |
26656-26659 |
CC |
denotes |
and |
T6129 |
26660-26669 |
JJ |
denotes |
olfactory |
T6130 |
26670-26676 |
NN |
denotes |
memory |
T6131 |
26676-26678 |
, |
denotes |
, |
T6132 |
26678-26681 |
DT |
denotes |
the |
T6133 |
26689-26699 |
NN |
denotes |
experiment |
T6134 |
26682-26688 |
NN |
denotes |
memory |
T6135 |
26700-26703 |
VBD |
denotes |
was |
T6136 |
26713-26717 |
IN |
denotes |
with |
T6137 |
26718-26722 |
CD |
denotes |
nine |
T6138 |
26744-26748 |
NNS |
denotes |
mice |
T6139 |
26723-26733 |
JJ |
denotes |
additional |
T6140 |
26734-26738 |
NN |
denotes |
GluR |
T6141 |
26739-26743 |
NN |
denotes |
BΔFB |
T6142 |
26738-26739 |
HYPH |
denotes |
- |
T6143 |
26749-26752 |
CC |
denotes |
and |
T6144 |
26753-26756 |
CD |
denotes |
two |
T6145 |
26776-26783 |
NNS |
denotes |
animals |
T6146 |
26757-26761 |
NN |
denotes |
GluR |
T6147 |
26762-26767 |
NN |
denotes |
B2lox |
T6148 |
26761-26762 |
HYPH |
denotes |
- |
T6149 |
26768-26775 |
NN |
denotes |
control |
T6150 |
26784-26785 |
-LRB- |
denotes |
( |
T6151 |
26785-26794 |
VBN |
denotes |
indicated |
T6152 |
26795-26799 |
IN |
denotes |
with |
T6153 |
26800-26806 |
VBN |
denotes |
shaded |
T6154 |
26807-26814 |
NNS |
denotes |
symbols |
T6155 |
26815-26817 |
IN |
denotes |
in |
T6156 |
26818-26824 |
NN |
denotes |
Figure |
T6157 |
26825-26827 |
NN |
denotes |
4A |
T6158 |
26827-26828 |
-RRB- |
denotes |
) |
T6159 |
26828-26830 |
, |
denotes |
, |
T6160 |
26830-26839 |
VBG |
denotes |
resulting |
T6161 |
26840-26842 |
IN |
denotes |
in |
T6162 |
26843-26846 |
DT |
denotes |
the |
T6163 |
26852-26856 |
NN |
denotes |
mean |
T6164 |
26847-26851 |
JJ |
denotes |
same |
T6165 |
26856-26858 |
, |
denotes |
, |
T6166 |
26858-26869 |
NN |
denotes |
variability |
T6167 |
26869-26871 |
, |
denotes |
, |
T6168 |
26871-26874 |
CC |
denotes |
and |
T6169 |
26875-26880 |
NN |
denotes |
range |
T6170 |
26881-26883 |
IN |
denotes |
of |
T6171 |
26884-26890 |
NN |
denotes |
memory |
T6172 |
26891-26902 |
NN |
denotes |
performance |
T6173 |
26903-26904 |
-LRB- |
denotes |
( |
T6174 |
26941-26942 |
NN |
denotes |
% |
T6175 |
26904-26911 |
NN |
denotes |
control |
T6176 |
26920-26921 |
NN |
denotes |
% |
T6177 |
26911-26913 |
: |
denotes |
: |
T6178 |
26913-26915 |
CD |
denotes |
89 |
T6179 |
26918-26920 |
CD |
denotes |
10 |
T6180 |
26916-26917 |
SYM |
denotes |
± |
T6181 |
26921-26922 |
: |
denotes |
; |
T6182 |
26923-26927 |
NN |
denotes |
GluR |
T6183 |
26928-26932 |
NN |
denotes |
BΔFB |
T6184 |
26927-26928 |
HYPH |
denotes |
- |
T6185 |
26932-26934 |
: |
denotes |
: |
T6186 |
26934-26936 |
CD |
denotes |
63 |
T6187 |
26939-26941 |
CD |
denotes |
14 |
T6188 |
26937-26938 |
SYM |
denotes |
± |
T6189 |
26942-26943 |
-RRB- |
denotes |
) |
T6190 |
26943-26944 |
. |
denotes |
. |
T6191 |
26944-27097 |
sentence |
denotes |
Subsequently, protein was extracted from olfactory bulbs, cortical areas, and hippocampi from each mouse, and GluR-B protein was quantified (Figure 4C). |
T6192 |
26945-26957 |
RB |
denotes |
Subsequently |
T6193 |
26971-26980 |
VBN |
denotes |
extracted |
T6194 |
26957-26959 |
, |
denotes |
, |
T6195 |
26959-26966 |
NN |
denotes |
protein |
T6196 |
26967-26970 |
VBD |
denotes |
was |
T6197 |
26981-26985 |
IN |
denotes |
from |
T6198 |
26986-26995 |
JJ |
denotes |
olfactory |
T6199 |
26996-27001 |
NNS |
denotes |
bulbs |
T6200 |
27001-27003 |
, |
denotes |
, |
T6201 |
27003-27011 |
JJ |
denotes |
cortical |
T6202 |
27012-27017 |
NNS |
denotes |
areas |
T6203 |
27017-27019 |
, |
denotes |
, |
T6204 |
27019-27022 |
CC |
denotes |
and |
T6205 |
27023-27033 |
NNS |
denotes |
hippocampi |
T6206 |
27034-27038 |
IN |
denotes |
from |
T6207 |
27039-27043 |
DT |
denotes |
each |
T6208 |
27044-27049 |
NN |
denotes |
mouse |
T6209 |
27049-27051 |
, |
denotes |
, |
T6210 |
27051-27054 |
CC |
denotes |
and |
T6211 |
27055-27059 |
NN |
denotes |
GluR |
T6212 |
27060-27061 |
NN |
denotes |
B |
T6213 |
27059-27060 |
HYPH |
denotes |
- |
T6214 |
27062-27069 |
NN |
denotes |
protein |
T6215 |
27074-27084 |
VBN |
denotes |
quantified |
T6216 |
27070-27073 |
VBD |
denotes |
was |
T6217 |
27085-27086 |
-LRB- |
denotes |
( |
T6218 |
27093-27095 |
NN |
denotes |
4C |
T6219 |
27086-27092 |
NN |
denotes |
Figure |
T6220 |
27095-27096 |
-RRB- |
denotes |
) |
T6221 |
27096-27097 |
. |
denotes |
. |
T6222 |
27097-27264 |
sentence |
denotes |
The summarized correlations are depicted in Figure 4D (two animals were used for immunofluorescent analysis that yielded the same results as in the first experiment). |
T6223 |
27098-27101 |
DT |
denotes |
The |
T6224 |
27113-27125 |
NNS |
denotes |
correlations |
T6225 |
27102-27112 |
VBN |
denotes |
summarized |
T6226 |
27130-27138 |
VBN |
denotes |
depicted |
T6227 |
27126-27129 |
VBP |
denotes |
are |
T6228 |
27139-27141 |
IN |
denotes |
in |
T6229 |
27142-27148 |
NN |
denotes |
Figure |
T6230 |
27149-27151 |
NN |
denotes |
4D |
T6231 |
27152-27153 |
-LRB- |
denotes |
( |
T6232 |
27170-27174 |
VBN |
denotes |
used |
T6233 |
27153-27156 |
CD |
denotes |
two |
T6234 |
27157-27164 |
NNS |
denotes |
animals |
T6235 |
27165-27169 |
VBD |
denotes |
were |
T6236 |
27175-27178 |
IN |
denotes |
for |
T6237 |
27179-27196 |
JJ |
denotes |
immunofluorescent |
T6238 |
27197-27205 |
NN |
denotes |
analysis |
T6239 |
27206-27210 |
WDT |
denotes |
that |
T6240 |
27211-27218 |
VBD |
denotes |
yielded |
T6241 |
27219-27222 |
DT |
denotes |
the |
T6242 |
27228-27235 |
NNS |
denotes |
results |
T6243 |
27223-27227 |
JJ |
denotes |
same |
T6244 |
27236-27238 |
IN |
denotes |
as |
T6245 |
27239-27241 |
IN |
denotes |
in |
T6246 |
27242-27245 |
DT |
denotes |
the |
T6247 |
27252-27262 |
NN |
denotes |
experiment |
T6248 |
27246-27251 |
JJ |
denotes |
first |
T6249 |
27262-27263 |
-RRB- |
denotes |
) |
T6250 |
27263-27264 |
. |
denotes |
. |
T6251 |
27264-27570 |
sentence |
denotes |
Whereas no learning or discrimination-related parameter correlated with residual protein levels (Figure 4D, R2 < 0.3), a strong correlation between memory and GluR-B protein was observed in hippocampus (Figure 4D, R2 = 0.72, p < 0.003, n = 10) and cortical areas (Figure 4D, R2 = 0.62, p < 0.006, n = 10). |
T6252 |
27265-27272 |
IN |
denotes |
Whereas |
T6253 |
27321-27331 |
VBD |
denotes |
correlated |
T6254 |
27273-27275 |
DT |
denotes |
no |
T6255 |
27311-27320 |
NN |
denotes |
parameter |
T6256 |
27276-27284 |
NN |
denotes |
learning |
T6257 |
27303-27310 |
VBN |
denotes |
related |
T6258 |
27285-27287 |
CC |
denotes |
or |
T6259 |
27288-27302 |
NN |
denotes |
discrimination |
T6260 |
27302-27303 |
HYPH |
denotes |
- |
T6261 |
27443-27451 |
VBN |
denotes |
observed |
T6262 |
27332-27336 |
IN |
denotes |
with |
T6263 |
27337-27345 |
JJ |
denotes |
residual |
T6264 |
27354-27360 |
NNS |
denotes |
levels |
T6265 |
27346-27353 |
NN |
denotes |
protein |
T6266 |
27361-27362 |
-LRB- |
denotes |
( |
T6267 |
27369-27371 |
NN |
denotes |
4D |
T6268 |
27362-27368 |
NN |
denotes |
Figure |
T6269 |
27371-27373 |
, |
denotes |
, |
T6270 |
27373-27375 |
NN |
denotes |
R2 |
T6271 |
27378-27381 |
CD |
denotes |
0.3 |
T6272 |
27376-27377 |
SYM |
denotes |
< |
T6273 |
27381-27382 |
-RRB- |
denotes |
) |
T6274 |
27382-27384 |
, |
denotes |
, |
T6275 |
27384-27385 |
DT |
denotes |
a |
T6276 |
27393-27404 |
NN |
denotes |
correlation |
T6277 |
27386-27392 |
JJ |
denotes |
strong |
T6278 |
27405-27412 |
IN |
denotes |
between |
T6279 |
27413-27419 |
NN |
denotes |
memory |
T6280 |
27420-27423 |
CC |
denotes |
and |
T6281 |
27424-27428 |
NN |
denotes |
GluR |
T6282 |
27429-27430 |
NN |
denotes |
B |
T6283 |
27428-27429 |
HYPH |
denotes |
- |
T6284 |
27431-27438 |
NN |
denotes |
protein |
T6285 |
27439-27442 |
VBD |
denotes |
was |
T6286 |
27452-27454 |
IN |
denotes |
in |
T6287 |
27455-27466 |
NN |
denotes |
hippocampus |
T6288 |
27467-27468 |
-LRB- |
denotes |
( |
T6289 |
27475-27477 |
NN |
denotes |
4D |
T6290 |
27468-27474 |
NN |
denotes |
Figure |
T6291 |
27477-27479 |
, |
denotes |
, |
T6292 |
27479-27481 |
NN |
denotes |
R2 |
T6293 |
27484-27488 |
CD |
denotes |
0.72 |
T6294 |
27482-27483 |
SYM |
denotes |
= |
T6295 |
27488-27490 |
, |
denotes |
, |
T6296 |
27490-27491 |
NN |
denotes |
p |
T6297 |
27494-27499 |
CD |
denotes |
0.003 |
T6298 |
27492-27493 |
SYM |
denotes |
< |
T6299 |
27499-27501 |
, |
denotes |
, |
T6300 |
27501-27502 |
NN |
denotes |
n |
T6301 |
27505-27507 |
CD |
denotes |
10 |
T6302 |
27503-27504 |
SYM |
denotes |
= |
T6303 |
27507-27508 |
-RRB- |
denotes |
) |
T6304 |
27509-27512 |
CC |
denotes |
and |
T6305 |
27513-27521 |
JJ |
denotes |
cortical |
T6306 |
27522-27527 |
NNS |
denotes |
areas |
T6307 |
27528-27529 |
-LRB- |
denotes |
( |
T6308 |
27536-27538 |
NN |
denotes |
4D |
T6309 |
27529-27535 |
NN |
denotes |
Figure |
T6310 |
27538-27540 |
, |
denotes |
, |
T6311 |
27540-27542 |
NN |
denotes |
R2 |
T6312 |
27545-27549 |
CD |
denotes |
0.62 |
T6313 |
27543-27544 |
SYM |
denotes |
= |
T6314 |
27549-27551 |
, |
denotes |
, |
T6315 |
27551-27552 |
NN |
denotes |
p |
T6316 |
27555-27560 |
CD |
denotes |
0.006 |
T6317 |
27553-27554 |
SYM |
denotes |
< |
T6318 |
27560-27562 |
, |
denotes |
, |
T6319 |
27562-27563 |
NN |
denotes |
n |
T6320 |
27566-27568 |
CD |
denotes |
10 |
T6321 |
27564-27565 |
SYM |
denotes |
= |
T6322 |
27568-27569 |
-RRB- |
denotes |
) |
T6323 |
27569-27570 |
. |
denotes |
. |
T6324 |
27570-27682 |
sentence |
denotes |
Only a weakly significant correlation was found in the olfactory bulb (Figure 4D, R2 = 0.48, p = 0.03, n = 10). |
T6325 |
27571-27575 |
RB |
denotes |
Only |
T6326 |
27597-27608 |
NN |
denotes |
correlation |
T6327 |
27576-27577 |
DT |
denotes |
a |
T6328 |
27578-27584 |
RB |
denotes |
weakly |
T6329 |
27585-27596 |
JJ |
denotes |
significant |
T6330 |
27613-27618 |
VBN |
denotes |
found |
T6331 |
27609-27612 |
VBD |
denotes |
was |
T6332 |
27619-27621 |
IN |
denotes |
in |
T6333 |
27622-27625 |
DT |
denotes |
the |
T6334 |
27636-27640 |
NN |
denotes |
bulb |
T6335 |
27626-27635 |
JJ |
denotes |
olfactory |
T6336 |
27641-27642 |
-LRB- |
denotes |
( |
T6337 |
27649-27651 |
NN |
denotes |
4D |
T6338 |
27642-27648 |
NN |
denotes |
Figure |
T6339 |
27651-27653 |
, |
denotes |
, |
T6340 |
27653-27655 |
NN |
denotes |
R2 |
T6341 |
27658-27662 |
CD |
denotes |
0.48 |
T6342 |
27656-27657 |
SYM |
denotes |
= |
T6343 |
27662-27664 |
, |
denotes |
, |
T6344 |
27664-27665 |
NN |
denotes |
p |
T6345 |
27668-27672 |
CD |
denotes |
0.03 |
T6346 |
27666-27667 |
SYM |
denotes |
= |
T6347 |
27672-27674 |
, |
denotes |
, |
T6348 |
27674-27675 |
NN |
denotes |
n |
T6349 |
27678-27680 |
CD |
denotes |
10 |
T6350 |
27676-27677 |
SYM |
denotes |
= |
T6351 |
27680-27681 |
-RRB- |
denotes |
) |
T6352 |
27681-27682 |
. |
denotes |
. |
T6353 |
27682-27876 |
sentence |
denotes |
GluR-A levels were unchanged from wild-type, indicating that compensatory up-regulation of other AMPAR subunits is unlikely (GluR-A levels relative to control: 1.02 ± 0.05, mean ± SEM, n = 10). |
T6354 |
27683-27687 |
NN |
denotes |
GluR |
T6355 |
27688-27689 |
NN |
denotes |
A |
T6356 |
27687-27688 |
HYPH |
denotes |
- |
T6357 |
27690-27696 |
NNS |
denotes |
levels |
T6358 |
27697-27701 |
VBD |
denotes |
were |
T6359 |
27702-27711 |
JJ |
denotes |
unchanged |
T6360 |
27712-27716 |
IN |
denotes |
from |
T6361 |
27717-27721 |
JJ |
denotes |
wild |
T6362 |
27722-27726 |
NN |
denotes |
type |
T6363 |
27721-27722 |
HYPH |
denotes |
- |
T6364 |
27726-27728 |
, |
denotes |
, |
T6365 |
27728-27738 |
VBG |
denotes |
indicating |
T6366 |
27739-27743 |
IN |
denotes |
that |
T6367 |
27795-27797 |
VBZ |
denotes |
is |
T6368 |
27744-27756 |
JJ |
denotes |
compensatory |
T6369 |
27760-27770 |
NN |
denotes |
regulation |
T6370 |
27757-27759 |
JJ |
denotes |
up |
T6371 |
27759-27760 |
HYPH |
denotes |
- |
T6372 |
27771-27773 |
IN |
denotes |
of |
T6373 |
27774-27779 |
JJ |
denotes |
other |
T6374 |
27786-27794 |
NNS |
denotes |
subunits |
T6375 |
27780-27785 |
NN |
denotes |
AMPAR |
T6376 |
27798-27806 |
JJ |
denotes |
unlikely |
T6377 |
27807-27808 |
-LRB- |
denotes |
( |
T6378 |
27815-27821 |
NNS |
denotes |
levels |
T6379 |
27808-27812 |
NN |
denotes |
GluR |
T6380 |
27813-27814 |
NN |
denotes |
A |
T6381 |
27812-27813 |
HYPH |
denotes |
- |
T6382 |
27822-27830 |
JJ |
denotes |
relative |
T6383 |
27831-27833 |
IN |
denotes |
to |
T6384 |
27834-27841 |
NN |
denotes |
control |
T6385 |
27841-27843 |
: |
denotes |
: |
T6386 |
27843-27847 |
CD |
denotes |
1.02 |
T6387 |
27850-27854 |
CD |
denotes |
0.05 |
T6388 |
27848-27849 |
SYM |
denotes |
± |
T6389 |
27872-27874 |
CD |
denotes |
10 |
T6390 |
27854-27856 |
, |
denotes |
, |
T6391 |
27856-27860 |
NN |
denotes |
mean |
T6392 |
27863-27866 |
NN |
denotes |
SEM |
T6393 |
27861-27862 |
SYM |
denotes |
± |
T6394 |
27866-27868 |
, |
denotes |
, |
T6395 |
27868-27869 |
NN |
denotes |
n |
T6396 |
27870-27871 |
SYM |
denotes |
= |
T6397 |
27874-27875 |
-RRB- |
denotes |
) |
T6398 |
27875-27876 |
. |
denotes |
. |
T6399 |
27876-28072 |
sentence |
denotes |
In summary, mice with reduced GluR-B levels in forebrain areas showed decreased olfactory memory, which correlated tightly with a reduction in GluR-B levels in the hippocampus and cortical areas. |
T6400 |
27877-27879 |
IN |
denotes |
In |
T6401 |
27940-27946 |
VBD |
denotes |
showed |
T6402 |
27880-27887 |
NN |
denotes |
summary |
T6403 |
27887-27889 |
, |
denotes |
, |
T6404 |
27889-27893 |
NNS |
denotes |
mice |
T6405 |
27894-27898 |
IN |
denotes |
with |
T6406 |
27899-27906 |
VBN |
denotes |
reduced |
T6407 |
27914-27920 |
NNS |
denotes |
levels |
T6408 |
27907-27911 |
NN |
denotes |
GluR |
T6409 |
27912-27913 |
NN |
denotes |
B |
T6410 |
27911-27912 |
HYPH |
denotes |
- |
T6411 |
27921-27923 |
IN |
denotes |
in |
T6412 |
27924-27933 |
NN |
denotes |
forebrain |
T6413 |
27934-27939 |
NNS |
denotes |
areas |
T6414 |
27947-27956 |
VBN |
denotes |
decreased |
T6415 |
27967-27973 |
NN |
denotes |
memory |
T6416 |
27957-27966 |
JJ |
denotes |
olfactory |
T6417 |
27973-27975 |
, |
denotes |
, |
T6418 |
27975-27980 |
WDT |
denotes |
which |
T6419 |
27981-27991 |
VBD |
denotes |
correlated |
T6420 |
27992-27999 |
RB |
denotes |
tightly |
T6421 |
28000-28004 |
IN |
denotes |
with |
T6422 |
28005-28006 |
DT |
denotes |
a |
T6423 |
28007-28016 |
NN |
denotes |
reduction |
T6424 |
28017-28019 |
IN |
denotes |
in |
T6425 |
28020-28024 |
NN |
denotes |
GluR |
T6426 |
28025-28026 |
NN |
denotes |
B |
T6427 |
28024-28025 |
HYPH |
denotes |
- |
T6428 |
28027-28033 |
NNS |
denotes |
levels |
T6429 |
28034-28036 |
IN |
denotes |
in |
T6430 |
28037-28040 |
DT |
denotes |
the |
T6431 |
28041-28052 |
NN |
denotes |
hippocampus |
T6432 |
28053-28056 |
CC |
denotes |
and |
T6433 |
28057-28065 |
JJ |
denotes |
cortical |
T6434 |
28066-28071 |
NNS |
denotes |
areas |
T6435 |
28071-28072 |
. |
denotes |
. |
T6436 |
28072-28338 |
sentence |
denotes |
Enhanced odor learning and discrimination, on the other hand, was independent of residual GluR-B levels in the olfactory bulb and other forebrain areas, indicating that moderate GluR-B reductions are sufficient to saturate enhanced odor learning and discrimination. |
T6437 |
28073-28081 |
VBN |
denotes |
Enhanced |
T6438 |
28087-28095 |
NN |
denotes |
learning |
T6439 |
28082-28086 |
NN |
denotes |
odor |
T6440 |
28135-28138 |
VBD |
denotes |
was |
T6441 |
28096-28099 |
CC |
denotes |
and |
T6442 |
28100-28114 |
NN |
denotes |
discrimination |
T6443 |
28114-28116 |
, |
denotes |
, |
T6444 |
28116-28118 |
IN |
denotes |
on |
T6445 |
28119-28122 |
DT |
denotes |
the |
T6446 |
28129-28133 |
NN |
denotes |
hand |
T6447 |
28123-28128 |
JJ |
denotes |
other |
T6448 |
28133-28135 |
, |
denotes |
, |
T6449 |
28139-28150 |
JJ |
denotes |
independent |
T6450 |
28151-28153 |
IN |
denotes |
of |
T6451 |
28154-28162 |
JJ |
denotes |
residual |
T6452 |
28170-28176 |
NNS |
denotes |
levels |
T6453 |
28163-28167 |
NN |
denotes |
GluR |
T6454 |
28168-28169 |
NN |
denotes |
B |
T6455 |
28167-28168 |
HYPH |
denotes |
- |
T6456 |
28177-28179 |
IN |
denotes |
in |
T6457 |
28180-28183 |
DT |
denotes |
the |
T6458 |
28194-28198 |
NN |
denotes |
bulb |
T6459 |
28184-28193 |
JJ |
denotes |
olfactory |
T6460 |
28199-28202 |
CC |
denotes |
and |
T6461 |
28203-28208 |
JJ |
denotes |
other |
T6462 |
28219-28224 |
NNS |
denotes |
areas |
T6463 |
28209-28218 |
NN |
denotes |
forebrain |
T6464 |
28224-28226 |
, |
denotes |
, |
T6465 |
28226-28236 |
VBG |
denotes |
indicating |
T6466 |
28237-28241 |
IN |
denotes |
that |
T6467 |
28269-28272 |
VBP |
denotes |
are |
T6468 |
28242-28250 |
JJ |
denotes |
moderate |
T6469 |
28258-28268 |
NNS |
denotes |
reductions |
T6470 |
28251-28255 |
NN |
denotes |
GluR |
T6471 |
28256-28257 |
NN |
denotes |
B |
T6472 |
28255-28256 |
HYPH |
denotes |
- |
T6473 |
28273-28283 |
JJ |
denotes |
sufficient |
T6474 |
28284-28286 |
TO |
denotes |
to |
T6475 |
28287-28295 |
VB |
denotes |
saturate |
T6476 |
28296-28304 |
VBN |
denotes |
enhanced |
T6477 |
28310-28318 |
NN |
denotes |
learning |
T6478 |
28305-28309 |
NN |
denotes |
odor |
T6479 |
28319-28322 |
CC |
denotes |
and |
T6480 |
28323-28337 |
NN |
denotes |
discrimination |
T6481 |
28337-28338 |
. |
denotes |
. |
T6482 |
28338-28587 |
sentence |
denotes |
Thus, although both are mediated by alterations in the AMPAR subunit GluR-B, due to the qualitatively different dose-response curves, the phenotypes regarding olfactory memory, and olfactory learning/discrimination must be mechanistically distinct. |
T6483 |
28339-28343 |
RB |
denotes |
Thus |
T6484 |
28559-28561 |
VB |
denotes |
be |
T6485 |
28343-28345 |
, |
denotes |
, |
T6486 |
28345-28353 |
IN |
denotes |
although |
T6487 |
28363-28371 |
VBN |
denotes |
mediated |
T6488 |
28354-28358 |
DT |
denotes |
both |
T6489 |
28359-28362 |
VBP |
denotes |
are |
T6490 |
28372-28374 |
IN |
denotes |
by |
T6491 |
28375-28386 |
NNS |
denotes |
alterations |
T6492 |
28387-28389 |
IN |
denotes |
in |
T6493 |
28390-28393 |
DT |
denotes |
the |
T6494 |
28400-28407 |
NN |
denotes |
subunit |
T6495 |
28394-28399 |
NN |
denotes |
AMPAR |
T6496 |
28408-28412 |
NN |
denotes |
GluR |
T6497 |
28413-28414 |
NN |
denotes |
B |
T6498 |
28412-28413 |
HYPH |
denotes |
- |
T6499 |
28414-28416 |
, |
denotes |
, |
T6500 |
28416-28419 |
IN |
denotes |
due |
T6501 |
28420-28422 |
IN |
denotes |
to |
T6502 |
28423-28426 |
DT |
denotes |
the |
T6503 |
28465-28471 |
NNS |
denotes |
curves |
T6504 |
28427-28440 |
RB |
denotes |
qualitatively |
T6505 |
28441-28450 |
JJ |
denotes |
different |
T6506 |
28451-28455 |
NN |
denotes |
dose |
T6507 |
28456-28464 |
NN |
denotes |
response |
T6508 |
28455-28456 |
HYPH |
denotes |
- |
T6509 |
28471-28473 |
, |
denotes |
, |
T6510 |
28473-28476 |
DT |
denotes |
the |
T6511 |
28477-28487 |
NNS |
denotes |
phenotypes |
T6512 |
28488-28497 |
VBG |
denotes |
regarding |
T6513 |
28498-28507 |
JJ |
denotes |
olfactory |
T6514 |
28508-28514 |
NN |
denotes |
memory |
T6515 |
28514-28516 |
, |
denotes |
, |
T6516 |
28516-28519 |
CC |
denotes |
and |
T6517 |
28520-28529 |
JJ |
denotes |
olfactory |
T6518 |
28539-28553 |
NN |
denotes |
discrimination |
T6519 |
28530-28538 |
NN |
denotes |
learning |
T6520 |
28538-28539 |
HYPH |
denotes |
/ |
T6521 |
28554-28558 |
MD |
denotes |
must |
T6522 |
28562-28577 |
RB |
denotes |
mechanistically |
T6523 |
28578-28586 |
JJ |
denotes |
distinct |
T6524 |
28586-28587 |
. |
denotes |
. |
T6879 |
28589-28596 |
JJ |
denotes |
Partial |
T6880 |
28597-28603 |
NN |
denotes |
Rescue |
T6881 |
28604-28606 |
IN |
denotes |
of |
T6882 |
28607-28616 |
JJ |
denotes |
Olfactory |
T6883 |
28624-28631 |
NN |
denotes |
Deficit |
T6884 |
28617-28623 |
NN |
denotes |
Memory |
T6885 |
28632-28634 |
IN |
denotes |
by |
T6886 |
28635-28644 |
JJ |
denotes |
Selective |
T6887 |
28663-28673 |
NN |
denotes |
Expression |
T6888 |
28645-28655 |
JJ |
denotes |
Transgenic |
T6889 |
28656-28660 |
NN |
denotes |
GluR |
T6890 |
28661-28662 |
NN |
denotes |
B |
T6891 |
28660-28661 |
HYPH |
denotes |
- |
T6892 |
28674-28676 |
IN |
denotes |
in |
T6893 |
28677-28688 |
NN |
denotes |
Hippocampus |
T6894 |
28689-28692 |
CC |
denotes |
and |
T6895 |
28693-28701 |
JJ |
denotes |
Piriform |
T6896 |
28702-28708 |
NN |
denotes |
Cortex |
T6897 |
28709-28711 |
IN |
denotes |
in |
T6898 |
28712-28716 |
NN |
denotes |
GluR |
T6899 |
28717-28721 |
NN |
denotes |
BΔFB |
T6900 |
28716-28717 |
HYPH |
denotes |
- |
T6901 |
28722-28726 |
NNS |
denotes |
Mice |
T6902 |
28726-28910 |
sentence |
denotes |
The effect of selective GluR-B depletion in mice indicated that GluR-B-containing AMPARs in the hippocampus, and/or (olfactory) cortex are likely to be important for olfactory memory. |
T6903 |
28727-28730 |
DT |
denotes |
The |
T6904 |
28731-28737 |
NN |
denotes |
effect |
T6905 |
28776-28785 |
VBD |
denotes |
indicated |
T6906 |
28738-28740 |
IN |
denotes |
of |
T6907 |
28741-28750 |
JJ |
denotes |
selective |
T6908 |
28758-28767 |
NN |
denotes |
depletion |
T6909 |
28751-28755 |
NN |
denotes |
GluR |
T6910 |
28756-28757 |
NN |
denotes |
B |
T6911 |
28755-28756 |
HYPH |
denotes |
- |
T6912 |
28768-28770 |
IN |
denotes |
in |
T6913 |
28771-28775 |
NNS |
denotes |
mice |
T6914 |
28786-28790 |
IN |
denotes |
that |
T6915 |
28862-28865 |
VBP |
denotes |
are |
T6916 |
28791-28795 |
NN |
denotes |
GluR |
T6917 |
28796-28797 |
NN |
denotes |
B |
T6918 |
28795-28796 |
HYPH |
denotes |
- |
T6919 |
28798-28808 |
VBG |
denotes |
containing |
T6920 |
28797-28798 |
HYPH |
denotes |
- |
T6921 |
28809-28815 |
NNS |
denotes |
AMPARs |
T6922 |
28816-28818 |
IN |
denotes |
in |
T6923 |
28819-28822 |
DT |
denotes |
the |
T6924 |
28823-28834 |
NN |
denotes |
hippocampus |
T6925 |
28834-28836 |
, |
denotes |
, |
T6926 |
28836-28839 |
CC |
denotes |
and |
T6927 |
28839-28840 |
HYPH |
denotes |
/ |
T6928 |
28840-28842 |
CC |
denotes |
or |
T6929 |
28843-28844 |
-LRB- |
denotes |
( |
T6930 |
28855-28861 |
NN |
denotes |
cortex |
T6931 |
28844-28853 |
JJ |
denotes |
olfactory |
T6932 |
28853-28854 |
-RRB- |
denotes |
) |
T6933 |
28866-28872 |
JJ |
denotes |
likely |
T6934 |
28873-28875 |
TO |
denotes |
to |
T6935 |
28876-28878 |
VB |
denotes |
be |
T6936 |
28879-28888 |
JJ |
denotes |
important |
T6937 |
28889-28892 |
IN |
denotes |
for |
T6938 |
28893-28902 |
JJ |
denotes |
olfactory |
T6939 |
28903-28909 |
NN |
denotes |
memory |
T6940 |
28909-28910 |
. |
denotes |
. |
T6941 |
28910-29134 |
sentence |
denotes |
The olfactory memory phenotype could be due to depletion of GluR-B in olfactory cortex or hippocampus; enhanced learning and discrimination capabilities might rather be evoked by AMPARs lacking GluR-B in the olfactory bulb. |
T6942 |
28911-28914 |
DT |
denotes |
The |
T6943 |
28932-28941 |
NN |
denotes |
phenotype |
T6944 |
28915-28924 |
JJ |
denotes |
olfactory |
T6945 |
28925-28931 |
NN |
denotes |
memory |
T6946 |
28948-28950 |
VB |
denotes |
be |
T6947 |
28942-28947 |
MD |
denotes |
could |
T6948 |
29080-29086 |
VBN |
denotes |
evoked |
T6949 |
28951-28954 |
IN |
denotes |
due |
T6950 |
28955-28957 |
IN |
denotes |
to |
T6951 |
28958-28967 |
NN |
denotes |
depletion |
T6952 |
28968-28970 |
IN |
denotes |
of |
T6953 |
28971-28975 |
NN |
denotes |
GluR |
T6954 |
28976-28977 |
NN |
denotes |
B |
T6955 |
28975-28976 |
HYPH |
denotes |
- |
T6956 |
28978-28980 |
IN |
denotes |
in |
T6957 |
28981-28990 |
JJ |
denotes |
olfactory |
T6958 |
28991-28997 |
NN |
denotes |
cortex |
T6959 |
28998-29000 |
CC |
denotes |
or |
T6960 |
29001-29012 |
NN |
denotes |
hippocampus |
T6961 |
29012-29013 |
: |
denotes |
; |
T6962 |
29014-29022 |
VBN |
denotes |
enhanced |
T6963 |
29051-29063 |
NNS |
denotes |
capabilities |
T6964 |
29023-29031 |
NN |
denotes |
learning |
T6965 |
29032-29035 |
CC |
denotes |
and |
T6966 |
29036-29050 |
NN |
denotes |
discrimination |
T6967 |
29064-29069 |
MD |
denotes |
might |
T6968 |
29070-29076 |
RB |
denotes |
rather |
T6969 |
29077-29079 |
VB |
denotes |
be |
T6970 |
29087-29089 |
IN |
denotes |
by |
T6971 |
29090-29096 |
NNS |
denotes |
AMPARs |
T6972 |
29097-29104 |
VBG |
denotes |
lacking |
T6973 |
29105-29109 |
NN |
denotes |
GluR |
T6974 |
29110-29111 |
NN |
denotes |
B |
T6975 |
29109-29110 |
HYPH |
denotes |
- |
T6976 |
29112-29114 |
IN |
denotes |
in |
T6977 |
29115-29118 |
DT |
denotes |
the |
T6978 |
29129-29133 |
NN |
denotes |
bulb |
T6979 |
29119-29128 |
JJ |
denotes |
olfactory |
T6980 |
29133-29134 |
. |
denotes |
. |
T6981 |
29134-29426 |
sentence |
denotes |
To obtain independent evidence for this spatial and mechanistic dissection of the roles of Ca2+-permeable AMPARs, we expressed by transgenic means N-terminally green fluorescent protein (GFP)-tagged GluR-B specifically in hippocampus and piriform cortex of GluR-BΔFB mice (Figure 5A and 5B). |
T6982 |
29135-29137 |
TO |
denotes |
To |
T6983 |
29138-29144 |
VB |
denotes |
obtain |
T6984 |
29252-29261 |
VBD |
denotes |
expressed |
T6985 |
29145-29156 |
JJ |
denotes |
independent |
T6986 |
29157-29165 |
NN |
denotes |
evidence |
T6987 |
29166-29169 |
IN |
denotes |
for |
T6988 |
29170-29174 |
DT |
denotes |
this |
T6989 |
29199-29209 |
NN |
denotes |
dissection |
T6990 |
29175-29182 |
JJ |
denotes |
spatial |
T6991 |
29183-29186 |
CC |
denotes |
and |
T6992 |
29187-29198 |
JJ |
denotes |
mechanistic |
T6993 |
29210-29212 |
IN |
denotes |
of |
T6994 |
29213-29216 |
DT |
denotes |
the |
T6995 |
29217-29222 |
NNS |
denotes |
roles |
T6996 |
29223-29225 |
IN |
denotes |
of |
T6997 |
29226-29229 |
NN |
denotes |
Ca2 |
T6998 |
29231-29240 |
JJ |
denotes |
permeable |
T6999 |
29229-29230 |
SYM |
denotes |
+ |
T7000 |
29230-29231 |
HYPH |
denotes |
- |
T7001 |
29241-29247 |
NNS |
denotes |
AMPARs |
T7002 |
29247-29249 |
, |
denotes |
, |
T7003 |
29249-29251 |
PRP |
denotes |
we |
T7004 |
29262-29264 |
IN |
denotes |
by |
T7005 |
29265-29275 |
JJ |
denotes |
transgenic |
T7006 |
29276-29281 |
NNS |
denotes |
means |
T7007 |
29282-29283 |
NN |
denotes |
N |
T7008 |
29284-29294 |
RB |
denotes |
terminally |
T7009 |
29283-29284 |
HYPH |
denotes |
- |
T7010 |
29295-29300 |
JJ |
denotes |
green |
T7011 |
29313-29320 |
NN |
denotes |
protein |
T7012 |
29301-29312 |
JJ |
denotes |
fluorescent |
T7013 |
29327-29333 |
VBN |
denotes |
tagged |
T7014 |
29321-29322 |
-LRB- |
denotes |
( |
T7015 |
29322-29325 |
NN |
denotes |
GFP |
T7016 |
29325-29326 |
-RRB- |
denotes |
) |
T7017 |
29326-29327 |
HYPH |
denotes |
- |
T7018 |
29339-29340 |
NN |
denotes |
B |
T7019 |
29334-29338 |
NN |
denotes |
GluR |
T7020 |
29338-29339 |
HYPH |
denotes |
- |
T7021 |
29341-29353 |
RB |
denotes |
specifically |
T7022 |
29354-29356 |
IN |
denotes |
in |
T7023 |
29357-29368 |
NN |
denotes |
hippocampus |
T7024 |
29369-29372 |
CC |
denotes |
and |
T7025 |
29373-29381 |
JJ |
denotes |
piriform |
T7026 |
29382-29388 |
NN |
denotes |
cortex |
T7027 |
29389-29391 |
IN |
denotes |
of |
T7028 |
29392-29396 |
NN |
denotes |
GluR |
T7029 |
29397-29401 |
NN |
denotes |
BΔFB |
T7030 |
29396-29397 |
HYPH |
denotes |
- |
T7031 |
29402-29406 |
NNS |
denotes |
mice |
T7032 |
29407-29408 |
-LRB- |
denotes |
( |
T7033 |
29415-29417 |
NN |
denotes |
5A |
T7034 |
29408-29414 |
NN |
denotes |
Figure |
T7035 |
29418-29421 |
CC |
denotes |
and |
T7036 |
29422-29424 |
NN |
denotes |
5B |
T7037 |
29424-29425 |
-RRB- |
denotes |
) |
T7038 |
29425-29426 |
. |
denotes |
. |
T7039 |
29426-29629 |
sentence |
denotes |
In accordance with the proposed region-dependence, we expected that additional GluR-B subunits in hippocampus and/or piriform cortex improve odor memory but do not alter odor discrimination performance. |
T7040 |
29427-29429 |
IN |
denotes |
In |
T7041 |
29481-29489 |
VBD |
denotes |
expected |
T7042 |
29430-29440 |
NN |
denotes |
accordance |
T7043 |
29441-29445 |
IN |
denotes |
with |
T7044 |
29446-29449 |
DT |
denotes |
the |
T7045 |
29466-29476 |
NN |
denotes |
dependence |
T7046 |
29450-29458 |
VBN |
denotes |
proposed |
T7047 |
29459-29465 |
NN |
denotes |
region |
T7048 |
29465-29466 |
HYPH |
denotes |
- |
T7049 |
29476-29478 |
, |
denotes |
, |
T7050 |
29478-29480 |
PRP |
denotes |
we |
T7051 |
29490-29494 |
IN |
denotes |
that |
T7052 |
29560-29567 |
VBP |
denotes |
improve |
T7053 |
29495-29505 |
JJ |
denotes |
additional |
T7054 |
29513-29521 |
NNS |
denotes |
subunits |
T7055 |
29506-29510 |
NN |
denotes |
GluR |
T7056 |
29511-29512 |
NN |
denotes |
B |
T7057 |
29510-29511 |
HYPH |
denotes |
- |
T7058 |
29522-29524 |
IN |
denotes |
in |
T7059 |
29525-29536 |
NN |
denotes |
hippocampus |
T7060 |
29537-29540 |
CC |
denotes |
and |
T7061 |
29540-29541 |
HYPH |
denotes |
/ |
T7062 |
29541-29543 |
CC |
denotes |
or |
T7063 |
29544-29552 |
JJ |
denotes |
piriform |
T7064 |
29553-29559 |
NN |
denotes |
cortex |
T7065 |
29568-29572 |
NN |
denotes |
odor |
T7066 |
29573-29579 |
NN |
denotes |
memory |
T7067 |
29580-29583 |
CC |
denotes |
but |
T7068 |
29584-29586 |
VBP |
denotes |
do |
T7069 |
29591-29596 |
VB |
denotes |
alter |
T7070 |
29587-29590 |
RB |
denotes |
not |
T7071 |
29597-29601 |
NN |
denotes |
odor |
T7072 |
29602-29616 |
NN |
denotes |
discrimination |
T7073 |
29617-29628 |
NN |
denotes |
performance |
T7074 |
29628-29629 |
. |
denotes |
. |
T7075 |
29629-29910 |
sentence |
denotes |
The mouse line employed for this purpose, termed GluR-BRescue, had the genetic background of GluR-BΔFB mice but additionally carried a bidirectional module for β-galactosidase and GFPGluR-B expression, responsive to the tetracycline-controlled transcriptional transactivator [62]. |
T7076 |
29630-29633 |
DT |
denotes |
The |
T7077 |
29640-29644 |
NN |
denotes |
line |
T7078 |
29634-29639 |
NN |
denotes |
mouse |
T7079 |
29693-29696 |
VBD |
denotes |
had |
T7080 |
29645-29653 |
VBN |
denotes |
employed |
T7081 |
29654-29657 |
IN |
denotes |
for |
T7082 |
29658-29662 |
DT |
denotes |
this |
T7083 |
29663-29670 |
NN |
denotes |
purpose |
T7084 |
29670-29672 |
, |
denotes |
, |
T7085 |
29672-29678 |
VBN |
denotes |
termed |
T7086 |
29679-29683 |
NN |
denotes |
GluR |
T7087 |
29684-29691 |
NN |
denotes |
BRescue |
T7088 |
29683-29684 |
HYPH |
denotes |
- |
T7089 |
29691-29693 |
, |
denotes |
, |
T7090 |
29697-29700 |
DT |
denotes |
the |
T7091 |
29709-29719 |
NN |
denotes |
background |
T7092 |
29701-29708 |
JJ |
denotes |
genetic |
T7093 |
29720-29722 |
IN |
denotes |
of |
T7094 |
29723-29727 |
NN |
denotes |
GluR |
T7095 |
29728-29732 |
NN |
denotes |
BΔFB |
T7096 |
29727-29728 |
HYPH |
denotes |
- |
T7097 |
29733-29737 |
NNS |
denotes |
mice |
T7098 |
29738-29741 |
CC |
denotes |
but |
T7099 |
29742-29754 |
RB |
denotes |
additionally |
T7100 |
29755-29762 |
VBD |
denotes |
carried |
T7101 |
29763-29764 |
DT |
denotes |
a |
T7102 |
29779-29785 |
NN |
denotes |
module |
T7103 |
29765-29778 |
JJ |
denotes |
bidirectional |
T7104 |
29786-29789 |
IN |
denotes |
for |
T7105 |
29790-29791 |
NN |
denotes |
β |
T7106 |
29792-29805 |
NN |
denotes |
galactosidase |
T7107 |
29791-29792 |
HYPH |
denotes |
- |
T7108 |
29820-29830 |
NN |
denotes |
expression |
T7109 |
29806-29809 |
CC |
denotes |
and |
T7110 |
29810-29817 |
NN |
denotes |
GFPGluR |
T7111 |
29818-29819 |
NN |
denotes |
B |
T7112 |
29817-29818 |
HYPH |
denotes |
- |
T7113 |
29830-29832 |
, |
denotes |
, |
T7114 |
29832-29842 |
JJ |
denotes |
responsive |
T7115 |
29843-29845 |
IN |
denotes |
to |
T7116 |
29846-29849 |
DT |
denotes |
the |
T7117 |
29890-29904 |
NN |
denotes |
transactivator |
T7118 |
29850-29862 |
NN |
denotes |
tetracycline |
T7119 |
29863-29873 |
VBN |
denotes |
controlled |
T7120 |
29862-29863 |
HYPH |
denotes |
- |
T7121 |
29874-29889 |
JJ |
denotes |
transcriptional |
T7122 |
29905-29906 |
-LRB- |
denotes |
[ |
T7123 |
29906-29908 |
CD |
denotes |
62 |
T7124 |
29908-29909 |
-RRB- |
denotes |
] |
T7125 |
29909-29910 |
. |
denotes |
. |
T7126 |
29910-30074 |
sentence |
denotes |
The transactivator was under the control of a modified αCaMKII-promoter fragment to obtain high expression selectivity (Figure 5A; see also Materials and Methods). |
T7127 |
29911-29914 |
DT |
denotes |
The |
T7128 |
29915-29929 |
NN |
denotes |
transactivator |
T7129 |
29930-29933 |
VBD |
denotes |
was |
T7130 |
29934-29939 |
IN |
denotes |
under |
T7131 |
29940-29943 |
DT |
denotes |
the |
T7132 |
29944-29951 |
NN |
denotes |
control |
T7133 |
29952-29954 |
IN |
denotes |
of |
T7134 |
29955-29956 |
DT |
denotes |
a |
T7135 |
29983-29991 |
NN |
denotes |
fragment |
T7136 |
29957-29965 |
VBN |
denotes |
modified |
T7137 |
29966-29973 |
NN |
denotes |
αCaMKII |
T7138 |
29974-29982 |
NN |
denotes |
promoter |
T7139 |
29973-29974 |
HYPH |
denotes |
- |
T7140 |
29992-29994 |
TO |
denotes |
to |
T7141 |
29995-30001 |
VB |
denotes |
obtain |
T7142 |
30002-30006 |
JJ |
denotes |
high |
T7143 |
30018-30029 |
NN |
denotes |
selectivity |
T7144 |
30007-30017 |
NN |
denotes |
expression |
T7145 |
30030-30031 |
-LRB- |
denotes |
( |
T7146 |
30038-30040 |
NN |
denotes |
5A |
T7147 |
30031-30037 |
NN |
denotes |
Figure |
T7148 |
30040-30041 |
: |
denotes |
; |
T7149 |
30042-30045 |
VB |
denotes |
see |
T7150 |
30046-30050 |
RB |
denotes |
also |
T7151 |
30051-30060 |
NNS |
denotes |
Materials |
T7152 |
30061-30064 |
CC |
denotes |
and |
T7153 |
30065-30072 |
NNS |
denotes |
Methods |
T7154 |
30072-30073 |
-RRB- |
denotes |
) |
T7155 |
30073-30074 |
. |
denotes |
. |
T7156 |
30074-30216 |
sentence |
denotes |
The transgenic expression level of GFPGluR-B was 9.72% ± 1.25 (n = 3) in the hippocampus, compared with endogenous GluR-B (Figure 5C and 5D). |
T7157 |
30075-30078 |
DT |
denotes |
The |
T7158 |
30101-30106 |
NN |
denotes |
level |
T7159 |
30079-30089 |
JJ |
denotes |
transgenic |
T7160 |
30090-30100 |
NN |
denotes |
expression |
T7161 |
30120-30123 |
VBD |
denotes |
was |
T7162 |
30107-30109 |
IN |
denotes |
of |
T7163 |
30110-30117 |
NN |
denotes |
GFPGluR |
T7164 |
30118-30119 |
NN |
denotes |
B |
T7165 |
30117-30118 |
HYPH |
denotes |
- |
T7166 |
30124-30128 |
CD |
denotes |
9.72 |
T7167 |
30128-30129 |
NN |
denotes |
% |
T7168 |
30130-30131 |
SYM |
denotes |
± |
T7169 |
30132-30136 |
CD |
denotes |
1.25 |
T7170 |
30137-30138 |
-LRB- |
denotes |
( |
T7171 |
30142-30143 |
CD |
denotes |
3 |
T7172 |
30138-30139 |
NN |
denotes |
n |
T7173 |
30140-30141 |
SYM |
denotes |
= |
T7174 |
30143-30144 |
-RRB- |
denotes |
) |
T7175 |
30145-30147 |
IN |
denotes |
in |
T7176 |
30148-30151 |
DT |
denotes |
the |
T7177 |
30152-30163 |
NN |
denotes |
hippocampus |
T7178 |
30163-30165 |
, |
denotes |
, |
T7179 |
30165-30173 |
VBN |
denotes |
compared |
T7180 |
30174-30178 |
IN |
denotes |
with |
T7181 |
30179-30189 |
JJ |
denotes |
endogenous |
T7182 |
30195-30196 |
NN |
denotes |
B |
T7183 |
30190-30194 |
NN |
denotes |
GluR |
T7184 |
30194-30195 |
HYPH |
denotes |
- |
T7185 |
30197-30198 |
-LRB- |
denotes |
( |
T7186 |
30205-30207 |
NN |
denotes |
5C |
T7187 |
30198-30204 |
NN |
denotes |
Figure |
T7188 |
30208-30211 |
CC |
denotes |
and |
T7189 |
30212-30214 |
NN |
denotes |
5D |
T7190 |
30214-30215 |
-RRB- |
denotes |
) |
T7191 |
30215-30216 |
. |
denotes |
. |
T7192 |
30216-30463 |
sentence |
denotes |
Analysis of β-galactosidase activity and GFPGluR-B expression in brain sections of GluR-BRescue mice revealed expression in hippocampus and piriform cortex, whereas cortex, amygdala, and striatum only rarely showed any positive cells (Figure 5B). |
T7193 |
30217-30225 |
NN |
denotes |
Analysis |
T7194 |
30318-30326 |
VBD |
denotes |
revealed |
T7195 |
30226-30228 |
IN |
denotes |
of |
T7196 |
30229-30230 |
NN |
denotes |
β |
T7197 |
30231-30244 |
NN |
denotes |
galactosidase |
T7198 |
30230-30231 |
HYPH |
denotes |
- |
T7199 |
30245-30253 |
NN |
denotes |
activity |
T7200 |
30254-30257 |
CC |
denotes |
and |
T7201 |
30258-30265 |
NN |
denotes |
GFPGluR |
T7202 |
30266-30267 |
NN |
denotes |
B |
T7203 |
30265-30266 |
HYPH |
denotes |
- |
T7204 |
30268-30278 |
NN |
denotes |
expression |
T7205 |
30279-30281 |
IN |
denotes |
in |
T7206 |
30282-30287 |
NN |
denotes |
brain |
T7207 |
30288-30296 |
NNS |
denotes |
sections |
T7208 |
30297-30299 |
IN |
denotes |
of |
T7209 |
30300-30304 |
NN |
denotes |
GluR |
T7210 |
30305-30312 |
NN |
denotes |
BRescue |
T7211 |
30304-30305 |
HYPH |
denotes |
- |
T7212 |
30313-30317 |
NNS |
denotes |
mice |
T7213 |
30327-30337 |
NN |
denotes |
expression |
T7214 |
30338-30340 |
IN |
denotes |
in |
T7215 |
30341-30352 |
NN |
denotes |
hippocampus |
T7216 |
30353-30356 |
CC |
denotes |
and |
T7217 |
30357-30365 |
JJ |
denotes |
piriform |
T7218 |
30366-30372 |
NN |
denotes |
cortex |
T7219 |
30372-30374 |
, |
denotes |
, |
T7220 |
30374-30381 |
IN |
denotes |
whereas |
T7221 |
30425-30431 |
VBD |
denotes |
showed |
T7222 |
30382-30388 |
NN |
denotes |
cortex |
T7223 |
30388-30390 |
, |
denotes |
, |
T7224 |
30390-30398 |
NN |
denotes |
amygdala |
T7225 |
30398-30400 |
, |
denotes |
, |
T7226 |
30400-30403 |
CC |
denotes |
and |
T7227 |
30404-30412 |
NN |
denotes |
striatum |
T7228 |
30413-30417 |
RB |
denotes |
only |
T7229 |
30418-30424 |
RB |
denotes |
rarely |
T7230 |
30432-30435 |
DT |
denotes |
any |
T7231 |
30445-30450 |
NNS |
denotes |
cells |
T7232 |
30436-30444 |
JJ |
denotes |
positive |
T7233 |
30451-30452 |
-LRB- |
denotes |
( |
T7234 |
30459-30461 |
NN |
denotes |
5B |
T7235 |
30452-30458 |
NN |
denotes |
Figure |
T7236 |
30461-30462 |
-RRB- |
denotes |
) |
T7237 |
30462-30463 |
. |
denotes |
. |
T7238 |
30463-30600 |
sentence |
denotes |
Importantly, both the spatial pattern and intensity of GFPGluR-B expression were constant among all GluR-BRescue mice analyzed (n = 11). |
T7239 |
30464-30475 |
RB |
denotes |
Importantly |
T7240 |
30540-30544 |
VBD |
denotes |
were |
T7241 |
30475-30477 |
, |
denotes |
, |
T7242 |
30477-30481 |
CC |
denotes |
both |
T7243 |
30494-30501 |
NN |
denotes |
pattern |
T7244 |
30482-30485 |
DT |
denotes |
the |
T7245 |
30486-30493 |
JJ |
denotes |
spatial |
T7246 |
30502-30505 |
CC |
denotes |
and |
T7247 |
30506-30515 |
NN |
denotes |
intensity |
T7248 |
30516-30518 |
IN |
denotes |
of |
T7249 |
30519-30526 |
NN |
denotes |
GFPGluR |
T7250 |
30527-30528 |
NN |
denotes |
B |
T7251 |
30526-30527 |
HYPH |
denotes |
- |
T7252 |
30529-30539 |
NN |
denotes |
expression |
T7253 |
30545-30553 |
JJ |
denotes |
constant |
T7254 |
30554-30559 |
IN |
denotes |
among |
T7255 |
30560-30563 |
DT |
denotes |
all |
T7256 |
30577-30581 |
NNS |
denotes |
mice |
T7257 |
30564-30568 |
NN |
denotes |
GluR |
T7258 |
30569-30576 |
NN |
denotes |
BRescue |
T7259 |
30568-30569 |
HYPH |
denotes |
- |
T7260 |
30582-30590 |
VBN |
denotes |
analyzed |
T7261 |
30591-30592 |
-LRB- |
denotes |
( |
T7262 |
30596-30598 |
CD |
denotes |
11 |
T7263 |
30592-30593 |
NN |
denotes |
n |
T7264 |
30594-30595 |
SYM |
denotes |
= |
T7265 |
30598-30599 |
-RRB- |
denotes |
) |
T7266 |
30599-30600 |
. |
denotes |
. |
T7267 |
30600-31866 |
sentence |
denotes |
Figure 5 Specific Hippocampus and Piriform Cortex Expression of Transgenic GFPGluR-B
(A) Schematic diagrams depicting forebrain-specific GluR-B deletion as in Figure 2A and itTA-dependent expression of GFPGluR-B and nuclear-localized β-galactosidase (nLacZ) in GluR-BΔFB mice (termed GluR-BRescue). GFPGluR-B and nLacZ are both encoded by TgOCN1, and itTA is controlled by a fusion of the NR2C silencer element [91] and the αCaMKII promoter (termed TgCN12-itTA [92]).
(B) In coronal brain sections of mice positive for both transgenes (TgCN12-itTA and TgOCN1) β-galactosidase activity (blue, X-gal, counterstain by eosin) is restricted to hippocampal neurons in CA1, DG, and neurons in the piriform cortex. The same neurons show GFPGluR-B expression when analyzed in immunohistochemical sections with an antibody against GFP. Scale bars: 500 μm.
(C) Immunoblot detecting endogenous GluR-B and transgenic GFPGluR-B in the hippocampus of three different mice (#1, #2, #3).
(D) Relative quantification from (C) of transgenic GFPGluR-B compared with endogenous GluR-B in the hippocampus. Olfactory memory experiments with GluR-BRescue , and both GluR-BΔFB and GluR-B2lox mice as controls, were performed as described above (indicated with shaded symbols in Figure 6A). |
T7268 |
31686-31695 |
JJ |
denotes |
Olfactory |
T7269 |
31696-31702 |
NN |
denotes |
memory |
T7270 |
31703-31714 |
NNS |
denotes |
experiments |
T7271 |
31792-31801 |
VBN |
denotes |
performed |
T7272 |
31715-31719 |
IN |
denotes |
with |
T7273 |
31720-31724 |
NN |
denotes |
GluR |
T7274 |
31725-31732 |
NN |
denotes |
BRescue |
T7275 |
31724-31725 |
HYPH |
denotes |
- |
T7276 |
31733-31735 |
, |
denotes |
, |
T7277 |
31735-31738 |
CC |
denotes |
and |
T7278 |
31739-31743 |
CC |
denotes |
both |
T7279 |
31749-31753 |
NN |
denotes |
BΔFB |
T7280 |
31744-31748 |
NN |
denotes |
GluR |
T7281 |
31748-31749 |
HYPH |
denotes |
- |
T7282 |
31769-31773 |
NNS |
denotes |
mice |
T7283 |
31754-31757 |
CC |
denotes |
and |
T7284 |
31758-31762 |
NN |
denotes |
GluR |
T7285 |
31763-31768 |
NN |
denotes |
B2lox |
T7286 |
31762-31763 |
HYPH |
denotes |
- |
T7287 |
31774-31776 |
IN |
denotes |
as |
T7288 |
31777-31785 |
NNS |
denotes |
controls |
T7289 |
31785-31787 |
, |
denotes |
, |
T7290 |
31787-31791 |
VBD |
denotes |
were |
T7291 |
31802-31804 |
IN |
denotes |
as |
T7292 |
31805-31814 |
VBN |
denotes |
described |
T7293 |
31815-31820 |
RB |
denotes |
above |
T7294 |
31821-31822 |
-LRB- |
denotes |
( |
T7295 |
31822-31831 |
VBN |
denotes |
indicated |
T7296 |
31832-31836 |
IN |
denotes |
with |
T7297 |
31837-31843 |
VBN |
denotes |
shaded |
T7298 |
31844-31851 |
NNS |
denotes |
symbols |
T7299 |
31852-31854 |
IN |
denotes |
in |
T7300 |
31855-31861 |
NN |
denotes |
Figure |
T7301 |
31862-31864 |
NN |
denotes |
6A |
T7302 |
31864-31865 |
-RRB- |
denotes |
) |
T7303 |
31865-31866 |
. |
denotes |
. |
T7304 |
31866-32042 |
sentence |
denotes |
Memory was again highly reproducible in both GluR-BΔFB (66 ± 12%; n = 4) and GluR-B2lox (94 ± 2%; n = 3) mice, compared with experiments performed earlier (Figures 2E and 4A). |
T7305 |
31867-31873 |
NN |
denotes |
Memory |
T7306 |
31874-31877 |
VBD |
denotes |
was |
T7307 |
31878-31883 |
RB |
denotes |
again |
T7308 |
31884-31890 |
RB |
denotes |
highly |
T7309 |
31891-31903 |
JJ |
denotes |
reproducible |
T7310 |
31904-31906 |
IN |
denotes |
in |
T7311 |
31907-31911 |
CC |
denotes |
both |
T7312 |
31917-31921 |
NN |
denotes |
BΔFB |
T7313 |
31912-31916 |
NN |
denotes |
GluR |
T7314 |
31916-31917 |
HYPH |
denotes |
- |
T7315 |
31972-31976 |
NNS |
denotes |
mice |
T7316 |
31922-31923 |
-LRB- |
denotes |
( |
T7317 |
31930-31931 |
NN |
denotes |
% |
T7318 |
31923-31925 |
CD |
denotes |
66 |
T7319 |
31928-31930 |
CD |
denotes |
12 |
T7320 |
31926-31927 |
SYM |
denotes |
± |
T7321 |
31931-31932 |
: |
denotes |
; |
T7322 |
31933-31934 |
NN |
denotes |
n |
T7323 |
31937-31938 |
CD |
denotes |
4 |
T7324 |
31935-31936 |
SYM |
denotes |
= |
T7325 |
31938-31939 |
-RRB- |
denotes |
) |
T7326 |
31940-31943 |
CC |
denotes |
and |
T7327 |
31944-31948 |
NN |
denotes |
GluR |
T7328 |
31949-31954 |
NN |
denotes |
B2lox |
T7329 |
31948-31949 |
HYPH |
denotes |
- |
T7330 |
31955-31956 |
-LRB- |
denotes |
( |
T7331 |
31962-31963 |
NN |
denotes |
% |
T7332 |
31956-31958 |
CD |
denotes |
94 |
T7333 |
31961-31962 |
CD |
denotes |
2 |
T7334 |
31959-31960 |
SYM |
denotes |
± |
T7335 |
31963-31964 |
: |
denotes |
; |
T7336 |
31965-31966 |
NN |
denotes |
n |
T7337 |
31969-31970 |
CD |
denotes |
3 |
T7338 |
31967-31968 |
SYM |
denotes |
= |
T7339 |
31970-31971 |
-RRB- |
denotes |
) |
T7340 |
31976-31978 |
, |
denotes |
, |
T7341 |
31978-31986 |
VBN |
denotes |
compared |
T7342 |
31987-31991 |
IN |
denotes |
with |
T7343 |
31992-32003 |
NNS |
denotes |
experiments |
T7344 |
32004-32013 |
VBN |
denotes |
performed |
T7345 |
32014-32021 |
RBR |
denotes |
earlier |
T7346 |
32022-32023 |
-LRB- |
denotes |
( |
T7347 |
32031-32033 |
NN |
denotes |
2E |
T7348 |
32023-32030 |
NNS |
denotes |
Figures |
T7349 |
32034-32037 |
CC |
denotes |
and |
T7350 |
32038-32040 |
NN |
denotes |
4A |
T7351 |
32040-32041 |
-RRB- |
denotes |
) |
T7352 |
32041-32042 |
. |
denotes |
. |
T7353 |
32042-32197 |
sentence |
denotes |
Importantly, olfactory memory in GluR-BRescue mice was intermediate (75 ± 15%, n = 8), below GluR-B2lox control levels, but better than in GluR-BΔFB mice. |
T7354 |
32043-32054 |
RB |
denotes |
Importantly |
T7355 |
32094-32097 |
VBD |
denotes |
was |
T7356 |
32054-32056 |
, |
denotes |
, |
T7357 |
32056-32065 |
JJ |
denotes |
olfactory |
T7358 |
32066-32072 |
NN |
denotes |
memory |
T7359 |
32073-32075 |
IN |
denotes |
in |
T7360 |
32076-32080 |
NN |
denotes |
GluR |
T7361 |
32081-32088 |
NN |
denotes |
BRescue |
T7362 |
32080-32081 |
HYPH |
denotes |
- |
T7363 |
32089-32093 |
NNS |
denotes |
mice |
T7364 |
32098-32110 |
JJ |
denotes |
intermediate |
T7365 |
32111-32112 |
-LRB- |
denotes |
( |
T7366 |
32119-32120 |
NN |
denotes |
% |
T7367 |
32112-32114 |
CD |
denotes |
75 |
T7368 |
32117-32119 |
CD |
denotes |
15 |
T7369 |
32115-32116 |
SYM |
denotes |
± |
T7370 |
32120-32122 |
, |
denotes |
, |
T7371 |
32122-32123 |
NN |
denotes |
n |
T7372 |
32126-32127 |
CD |
denotes |
8 |
T7373 |
32124-32125 |
SYM |
denotes |
= |
T7374 |
32127-32128 |
-RRB- |
denotes |
) |
T7375 |
32128-32130 |
, |
denotes |
, |
T7376 |
32130-32135 |
IN |
denotes |
below |
T7377 |
32136-32140 |
NN |
denotes |
GluR |
T7378 |
32141-32146 |
NN |
denotes |
B2lox |
T7379 |
32140-32141 |
HYPH |
denotes |
- |
T7380 |
32155-32161 |
NNS |
denotes |
levels |
T7381 |
32147-32154 |
NN |
denotes |
control |
T7382 |
32161-32163 |
, |
denotes |
, |
T7383 |
32163-32166 |
CC |
denotes |
but |
T7384 |
32167-32173 |
JJR |
denotes |
better |
T7385 |
32174-32178 |
IN |
denotes |
than |
T7386 |
32179-32181 |
IN |
denotes |
in |
T7387 |
32182-32186 |
NN |
denotes |
GluR |
T7388 |
32187-32191 |
NN |
denotes |
BΔFB |
T7389 |
32186-32187 |
HYPH |
denotes |
- |
T7390 |
32192-32196 |
NNS |
denotes |
mice |
T7391 |
32196-32197 |
. |
denotes |
. |
T7392 |
32197-32394 |
sentence |
denotes |
Assessing memory under extinction-free condition, where each trial was rewarded, confirmed again that the memory deficit was a true memory deficit and not due to increased extinction (Figure S3B). |
T7393 |
32198-32207 |
VBG |
denotes |
Assessing |
T7394 |
32279-32288 |
VBN |
denotes |
confirmed |
T7395 |
32208-32214 |
NN |
denotes |
memory |
T7396 |
32215-32220 |
IN |
denotes |
under |
T7397 |
32221-32231 |
NN |
denotes |
extinction |
T7398 |
32232-32236 |
JJ |
denotes |
free |
T7399 |
32231-32232 |
HYPH |
denotes |
- |
T7400 |
32237-32246 |
NN |
denotes |
condition |
T7401 |
32246-32248 |
, |
denotes |
, |
T7402 |
32248-32253 |
WRB |
denotes |
where |
T7403 |
32269-32277 |
VBN |
denotes |
rewarded |
T7404 |
32254-32258 |
DT |
denotes |
each |
T7405 |
32259-32264 |
NN |
denotes |
trial |
T7406 |
32265-32268 |
VBD |
denotes |
was |
T7407 |
32277-32279 |
, |
denotes |
, |
T7408 |
32289-32294 |
RB |
denotes |
again |
T7409 |
32295-32299 |
IN |
denotes |
that |
T7410 |
32319-32322 |
VBD |
denotes |
was |
T7411 |
32300-32303 |
DT |
denotes |
the |
T7412 |
32311-32318 |
NN |
denotes |
deficit |
T7413 |
32304-32310 |
NN |
denotes |
memory |
T7414 |
32323-32324 |
DT |
denotes |
a |
T7415 |
32337-32344 |
NN |
denotes |
deficit |
T7416 |
32325-32329 |
JJ |
denotes |
true |
T7417 |
32330-32336 |
NN |
denotes |
memory |
T7418 |
32345-32348 |
CC |
denotes |
and |
T7419 |
32349-32352 |
RB |
denotes |
not |
T7420 |
32353-32356 |
IN |
denotes |
due |
T7421 |
32357-32359 |
IN |
denotes |
to |
T7422 |
32360-32369 |
VBN |
denotes |
increased |
T7423 |
32370-32380 |
NN |
denotes |
extinction |
T7424 |
32381-32382 |
-LRB- |
denotes |
( |
T7425 |
32389-32392 |
NN |
denotes |
S3B |
T7426 |
32382-32388 |
NN |
denotes |
Figure |
T7427 |
32392-32393 |
-RRB- |
denotes |
) |
T7428 |
32393-32394 |
. |
denotes |
. |
T7429 |
32394-32515 |
sentence |
denotes |
Data from the experiments described in Figures 2 and 4 were combined to allow statistical comparison (Figure 6A and 6B). |
T7430 |
32395-32399 |
NNS |
denotes |
Data |
T7431 |
32455-32463 |
VBN |
denotes |
combined |
T7432 |
32400-32404 |
IN |
denotes |
from |
T7433 |
32405-32408 |
DT |
denotes |
the |
T7434 |
32409-32420 |
NNS |
denotes |
experiments |
T7435 |
32421-32430 |
VBN |
denotes |
described |
T7436 |
32431-32433 |
IN |
denotes |
in |
T7437 |
32434-32441 |
NNS |
denotes |
Figures |
T7438 |
32442-32443 |
CD |
denotes |
2 |
T7439 |
32444-32447 |
CC |
denotes |
and |
T7440 |
32448-32449 |
CD |
denotes |
4 |
T7441 |
32450-32454 |
VBD |
denotes |
were |
T7442 |
32464-32466 |
TO |
denotes |
to |
T7443 |
32467-32472 |
VB |
denotes |
allow |
T7444 |
32473-32484 |
JJ |
denotes |
statistical |
T7445 |
32485-32495 |
NN |
denotes |
comparison |
T7446 |
32496-32497 |
-LRB- |
denotes |
( |
T7447 |
32504-32506 |
NN |
denotes |
6A |
T7448 |
32497-32503 |
NN |
denotes |
Figure |
T7449 |
32507-32510 |
CC |
denotes |
and |
T7450 |
32511-32513 |
NN |
denotes |
6B |
T7451 |
32513-32514 |
-RRB- |
denotes |
) |
T7452 |
32514-32515 |
. |
denotes |
. |
T7453 |
32515-32975 |
sentence |
denotes |
In summary, GluR-BRescue mice showed both enhanced memory performances compared with GluR-BΔFB (overall ANOVA: F(2,41) = 13.6, p < 10−4; memoryRescue = 75 ± 15%, n = 8; memoryΔFB = 66 ± 14%, n = 22; p < 0.05; Figure 6A), but were still impaired relative to GluR-B2lox controls (memory2lox = 88 ± 8%, n = 14; p < 0.005), consistent with a partial rescue of the memory deficit by circumscribed transgenic GFPGluR-B expression in hippocampus and piriform cortex. |
T7454 |
32516-32518 |
IN |
denotes |
In |
T7455 |
32546-32552 |
VBD |
denotes |
showed |
T7456 |
32519-32526 |
NN |
denotes |
summary |
T7457 |
32526-32528 |
, |
denotes |
, |
T7458 |
32528-32532 |
NN |
denotes |
GluR |
T7459 |
32533-32540 |
NN |
denotes |
BRescue |
T7460 |
32532-32533 |
HYPH |
denotes |
- |
T7461 |
32541-32545 |
NNS |
denotes |
mice |
T7462 |
32553-32557 |
DT |
denotes |
both |
T7463 |
32574-32586 |
NNS |
denotes |
performances |
T7464 |
32558-32566 |
VBN |
denotes |
enhanced |
T7465 |
32567-32573 |
NN |
denotes |
memory |
T7466 |
32587-32595 |
VBN |
denotes |
compared |
T7467 |
32596-32600 |
IN |
denotes |
with |
T7468 |
32601-32605 |
NN |
denotes |
GluR |
T7469 |
32606-32610 |
NN |
denotes |
BΔFB |
T7470 |
32605-32606 |
HYPH |
denotes |
- |
T7471 |
32611-32612 |
-LRB- |
denotes |
( |
T7472 |
32732-32734 |
NN |
denotes |
6A |
T7473 |
32612-32619 |
JJ |
denotes |
overall |
T7474 |
32620-32625 |
NN |
denotes |
ANOVA |
T7475 |
32625-32627 |
: |
denotes |
: |
T7476 |
32627-32628 |
NN |
denotes |
F |
T7477 |
32637-32641 |
CD |
denotes |
13.6 |
T7478 |
32628-32629 |
-LRB- |
denotes |
( |
T7479 |
32629-32630 |
CD |
denotes |
2 |
T7480 |
32630-32631 |
, |
denotes |
, |
T7481 |
32631-32633 |
CD |
denotes |
41 |
T7482 |
32633-32634 |
-RRB- |
denotes |
) |
T7483 |
32635-32636 |
SYM |
denotes |
= |
T7484 |
32641-32643 |
, |
denotes |
, |
T7485 |
32643-32644 |
NN |
denotes |
p |
T7486 |
32650-32651 |
CD |
denotes |
4 |
T7487 |
32645-32646 |
SYM |
denotes |
< |
T7488 |
32647-32649 |
CD |
denotes |
10 |
T7489 |
32649-32650 |
SYM |
denotes |
− |
T7490 |
32651-32652 |
: |
denotes |
; |
T7491 |
32653-32665 |
NN |
denotes |
memoryRescue |
T7492 |
32675-32676 |
NN |
denotes |
% |
T7493 |
32666-32667 |
SYM |
denotes |
= |
T7494 |
32668-32670 |
CD |
denotes |
75 |
T7495 |
32673-32675 |
CD |
denotes |
15 |
T7496 |
32671-32672 |
SYM |
denotes |
± |
T7497 |
32676-32678 |
, |
denotes |
, |
T7498 |
32678-32679 |
NN |
denotes |
n |
T7499 |
32682-32683 |
CD |
denotes |
8 |
T7500 |
32680-32681 |
SYM |
denotes |
= |
T7501 |
32683-32684 |
: |
denotes |
; |
T7502 |
32685-32694 |
NN |
denotes |
memoryΔFB |
T7503 |
32704-32705 |
NN |
denotes |
% |
T7504 |
32695-32696 |
SYM |
denotes |
= |
T7505 |
32697-32699 |
CD |
denotes |
66 |
T7506 |
32702-32704 |
CD |
denotes |
14 |
T7507 |
32700-32701 |
SYM |
denotes |
± |
T7508 |
32705-32707 |
, |
denotes |
, |
T7509 |
32707-32708 |
NN |
denotes |
n |
T7510 |
32711-32713 |
CD |
denotes |
22 |
T7511 |
32709-32710 |
SYM |
denotes |
= |
T7512 |
32713-32714 |
: |
denotes |
; |
T7513 |
32715-32716 |
NN |
denotes |
p |
T7514 |
32719-32723 |
CD |
denotes |
0.05 |
T7515 |
32717-32718 |
SYM |
denotes |
< |
T7516 |
32723-32724 |
: |
denotes |
; |
T7517 |
32725-32731 |
NN |
denotes |
Figure |
T7518 |
32734-32735 |
-RRB- |
denotes |
) |
T7519 |
32735-32737 |
, |
denotes |
, |
T7520 |
32737-32740 |
CC |
denotes |
but |
T7521 |
32741-32745 |
VBD |
denotes |
were |
T7522 |
32752-32760 |
VBN |
denotes |
impaired |
T7523 |
32746-32751 |
RB |
denotes |
still |
T7524 |
32761-32769 |
RB |
denotes |
relative |
T7525 |
32770-32772 |
IN |
denotes |
to |
T7526 |
32773-32777 |
NN |
denotes |
GluR |
T7527 |
32778-32783 |
NN |
denotes |
B2lox |
T7528 |
32777-32778 |
HYPH |
denotes |
- |
T7529 |
32784-32792 |
NNS |
denotes |
controls |
T7530 |
32793-32794 |
-LRB- |
denotes |
( |
T7531 |
32828-32833 |
CD |
denotes |
0.005 |
T7532 |
32794-32804 |
NN |
denotes |
memory2lox |
T7533 |
32813-32814 |
NN |
denotes |
% |
T7534 |
32805-32806 |
SYM |
denotes |
= |
T7535 |
32807-32809 |
CD |
denotes |
88 |
T7536 |
32812-32813 |
CD |
denotes |
8 |
T7537 |
32810-32811 |
SYM |
denotes |
± |
T7538 |
32814-32816 |
, |
denotes |
, |
T7539 |
32816-32817 |
NN |
denotes |
n |
T7540 |
32820-32822 |
CD |
denotes |
14 |
T7541 |
32818-32819 |
SYM |
denotes |
= |
T7542 |
32822-32823 |
: |
denotes |
; |
T7543 |
32824-32825 |
NN |
denotes |
p |
T7544 |
32826-32827 |
SYM |
denotes |
< |
T7545 |
32833-32834 |
-RRB- |
denotes |
) |
T7546 |
32834-32836 |
, |
denotes |
, |
T7547 |
32836-32846 |
JJ |
denotes |
consistent |
T7548 |
32847-32851 |
IN |
denotes |
with |
T7549 |
32852-32853 |
DT |
denotes |
a |
T7550 |
32862-32868 |
NN |
denotes |
rescue |
T7551 |
32854-32861 |
JJ |
denotes |
partial |
T7552 |
32869-32871 |
IN |
denotes |
of |
T7553 |
32872-32875 |
DT |
denotes |
the |
T7554 |
32883-32890 |
NN |
denotes |
deficit |
T7555 |
32876-32882 |
NN |
denotes |
memory |
T7556 |
32891-32893 |
IN |
denotes |
by |
T7557 |
32894-32907 |
VBN |
denotes |
circumscribed |
T7558 |
32929-32939 |
NN |
denotes |
expression |
T7559 |
32908-32918 |
JJ |
denotes |
transgenic |
T7560 |
32919-32926 |
NN |
denotes |
GFPGluR |
T7561 |
32927-32928 |
NN |
denotes |
B |
T7562 |
32926-32927 |
HYPH |
denotes |
- |
T7563 |
32940-32942 |
IN |
denotes |
in |
T7564 |
32943-32954 |
NN |
denotes |
hippocampus |
T7565 |
32955-32958 |
CC |
denotes |
and |
T7566 |
32959-32967 |
JJ |
denotes |
piriform |
T7567 |
32968-32974 |
NN |
denotes |
cortex |
T7568 |
32974-32975 |
. |
denotes |
. |
T7569 |
32975-33181 |
sentence |
denotes |
Notably, the partial memory is in numerical agreement with the predictions from the protein correlation and the measurement of transgenic protein expression (see predicted memory, blue line, in Figure 6B). |
T7570 |
32976-32983 |
RB |
denotes |
Notably |
T7571 |
33004-33006 |
VBZ |
denotes |
is |
T7572 |
32983-32985 |
, |
denotes |
, |
T7573 |
32985-32988 |
DT |
denotes |
the |
T7574 |
32997-33003 |
NN |
denotes |
memory |
T7575 |
32989-32996 |
JJ |
denotes |
partial |
T7576 |
33007-33009 |
IN |
denotes |
in |
T7577 |
33010-33019 |
JJ |
denotes |
numerical |
T7578 |
33020-33029 |
NN |
denotes |
agreement |
T7579 |
33030-33034 |
IN |
denotes |
with |
T7580 |
33035-33038 |
DT |
denotes |
the |
T7581 |
33039-33050 |
NNS |
denotes |
predictions |
T7582 |
33051-33055 |
IN |
denotes |
from |
T7583 |
33056-33059 |
DT |
denotes |
the |
T7584 |
33068-33079 |
NN |
denotes |
correlation |
T7585 |
33060-33067 |
NN |
denotes |
protein |
T7586 |
33080-33083 |
CC |
denotes |
and |
T7587 |
33084-33087 |
DT |
denotes |
the |
T7588 |
33088-33099 |
NN |
denotes |
measurement |
T7589 |
33100-33102 |
IN |
denotes |
of |
T7590 |
33103-33113 |
JJ |
denotes |
transgenic |
T7591 |
33122-33132 |
NN |
denotes |
expression |
T7592 |
33114-33121 |
NN |
denotes |
protein |
T7593 |
33133-33134 |
-LRB- |
denotes |
( |
T7594 |
33134-33137 |
VB |
denotes |
see |
T7595 |
33138-33147 |
VBN |
denotes |
predicted |
T7596 |
33148-33154 |
NN |
denotes |
memory |
T7597 |
33154-33156 |
, |
denotes |
, |
T7598 |
33156-33160 |
JJ |
denotes |
blue |
T7599 |
33161-33165 |
NN |
denotes |
line |
T7600 |
33165-33167 |
, |
denotes |
, |
T7601 |
33167-33169 |
IN |
denotes |
in |
T7602 |
33170-33176 |
NN |
denotes |
Figure |
T7603 |
33177-33179 |
NN |
denotes |
6B |
T7604 |
33179-33180 |
-RRB- |
denotes |
) |
T7605 |
33180-33181 |
. |
denotes |
. |
T7606 |
33181-33448 |
sentence |
denotes |
In the olfactory memory experiments with GluR-BΔFB animals, olfactory memory linearly depended on GluR-B expression in cortex and hippocampus with a slope of 9.1 ± 2.5% (cortex) and 8.9 ± 2.0% (hippocampus) increase in memory per 10% increase in protein (Figure 4D). |
T7607 |
33182-33184 |
IN |
denotes |
In |
T7608 |
33268-33276 |
VBD |
denotes |
depended |
T7609 |
33185-33188 |
DT |
denotes |
the |
T7610 |
33206-33217 |
NNS |
denotes |
experiments |
T7611 |
33189-33198 |
JJ |
denotes |
olfactory |
T7612 |
33199-33205 |
NN |
denotes |
memory |
T7613 |
33218-33222 |
IN |
denotes |
with |
T7614 |
33223-33227 |
NN |
denotes |
GluR |
T7615 |
33228-33232 |
NN |
denotes |
BΔFB |
T7616 |
33227-33228 |
HYPH |
denotes |
- |
T7617 |
33233-33240 |
NNS |
denotes |
animals |
T7618 |
33240-33242 |
, |
denotes |
, |
T7619 |
33242-33251 |
JJ |
denotes |
olfactory |
T7620 |
33252-33258 |
NN |
denotes |
memory |
T7621 |
33259-33267 |
RB |
denotes |
linearly |
T7622 |
33277-33279 |
IN |
denotes |
on |
T7623 |
33280-33284 |
NN |
denotes |
GluR |
T7624 |
33285-33286 |
NN |
denotes |
B |
T7625 |
33284-33285 |
HYPH |
denotes |
- |
T7626 |
33287-33297 |
NN |
denotes |
expression |
T7627 |
33298-33300 |
IN |
denotes |
in |
T7628 |
33301-33307 |
NN |
denotes |
cortex |
T7629 |
33308-33311 |
CC |
denotes |
and |
T7630 |
33312-33323 |
NN |
denotes |
hippocampus |
T7631 |
33324-33328 |
IN |
denotes |
with |
T7632 |
33329-33330 |
DT |
denotes |
a |
T7633 |
33331-33336 |
NN |
denotes |
slope |
T7634 |
33337-33339 |
IN |
denotes |
of |
T7635 |
33340-33343 |
CD |
denotes |
9.1 |
T7636 |
33346-33349 |
CD |
denotes |
2.5 |
T7637 |
33344-33345 |
SYM |
denotes |
± |
T7638 |
33349-33350 |
NN |
denotes |
% |
T7639 |
33351-33352 |
-LRB- |
denotes |
( |
T7640 |
33352-33358 |
NN |
denotes |
cortex |
T7641 |
33358-33359 |
-RRB- |
denotes |
) |
T7642 |
33360-33363 |
CC |
denotes |
and |
T7643 |
33364-33367 |
CD |
denotes |
8.9 |
T7644 |
33370-33373 |
CD |
denotes |
2.0 |
T7645 |
33368-33369 |
SYM |
denotes |
± |
T7646 |
33373-33374 |
NN |
denotes |
% |
T7647 |
33389-33397 |
NN |
denotes |
increase |
T7648 |
33375-33376 |
-LRB- |
denotes |
( |
T7649 |
33376-33387 |
NN |
denotes |
hippocampus |
T7650 |
33387-33388 |
-RRB- |
denotes |
) |
T7651 |
33398-33400 |
IN |
denotes |
in |
T7652 |
33401-33407 |
NN |
denotes |
memory |
T7653 |
33408-33411 |
IN |
denotes |
per |
T7654 |
33412-33414 |
CD |
denotes |
10 |
T7655 |
33414-33415 |
NN |
denotes |
% |
T7656 |
33416-33424 |
NN |
denotes |
increase |
T7657 |
33425-33427 |
IN |
denotes |
in |
T7658 |
33428-33435 |
NN |
denotes |
protein |
T7659 |
33436-33437 |
-LRB- |
denotes |
( |
T7660 |
33444-33446 |
NN |
denotes |
4D |
T7661 |
33437-33443 |
NN |
denotes |
Figure |
T7662 |
33446-33447 |
-RRB- |
denotes |
) |
T7663 |
33447-33448 |
. |
denotes |
. |
T7664 |
33448-33679 |
sentence |
denotes |
A 9.7% increase in GluR-B in these brain regions, as achieved by GluR-BRescue animals (Figure 5), is thus predicted to increase olfactory memory by approximately 9% throughout the heterogeneous population (blue line in Figure 6B). |
T7665 |
33449-33450 |
DT |
denotes |
A |
T7666 |
33456-33464 |
NN |
denotes |
increase |
T7667 |
33451-33454 |
CD |
denotes |
9.7 |
T7668 |
33454-33455 |
NN |
denotes |
% |
T7669 |
33555-33564 |
VBN |
denotes |
predicted |
T7670 |
33465-33467 |
IN |
denotes |
in |
T7671 |
33468-33472 |
NN |
denotes |
GluR |
T7672 |
33473-33474 |
NN |
denotes |
B |
T7673 |
33472-33473 |
HYPH |
denotes |
- |
T7674 |
33475-33477 |
IN |
denotes |
in |
T7675 |
33478-33483 |
DT |
denotes |
these |
T7676 |
33490-33497 |
NNS |
denotes |
regions |
T7677 |
33484-33489 |
NN |
denotes |
brain |
T7678 |
33497-33499 |
, |
denotes |
, |
T7679 |
33499-33501 |
IN |
denotes |
as |
T7680 |
33502-33510 |
VBN |
denotes |
achieved |
T7681 |
33511-33513 |
IN |
denotes |
by |
T7682 |
33514-33518 |
NN |
denotes |
GluR |
T7683 |
33519-33526 |
NN |
denotes |
BRescue |
T7684 |
33518-33519 |
HYPH |
denotes |
- |
T7685 |
33527-33534 |
NNS |
denotes |
animals |
T7686 |
33535-33536 |
-LRB- |
denotes |
( |
T7687 |
33536-33542 |
NN |
denotes |
Figure |
T7688 |
33543-33544 |
CD |
denotes |
5 |
T7689 |
33544-33545 |
-RRB- |
denotes |
) |
T7690 |
33545-33547 |
, |
denotes |
, |
T7691 |
33547-33549 |
VBZ |
denotes |
is |
T7692 |
33550-33554 |
RB |
denotes |
thus |
T7693 |
33565-33567 |
TO |
denotes |
to |
T7694 |
33568-33576 |
VB |
denotes |
increase |
T7695 |
33577-33586 |
JJ |
denotes |
olfactory |
T7696 |
33587-33593 |
NN |
denotes |
memory |
T7697 |
33594-33596 |
IN |
denotes |
by |
T7698 |
33597-33610 |
RB |
denotes |
approximately |
T7699 |
33611-33612 |
CD |
denotes |
9 |
T7700 |
33612-33613 |
NN |
denotes |
% |
T7701 |
33614-33624 |
IN |
denotes |
throughout |
T7702 |
33625-33628 |
DT |
denotes |
the |
T7703 |
33643-33653 |
NN |
denotes |
population |
T7704 |
33629-33642 |
JJ |
denotes |
heterogeneous |
T7705 |
33654-33655 |
-LRB- |
denotes |
( |
T7706 |
33660-33664 |
NN |
denotes |
line |
T7707 |
33655-33659 |
JJ |
denotes |
blue |
T7708 |
33665-33667 |
IN |
denotes |
in |
T7709 |
33668-33674 |
NN |
denotes |
Figure |
T7710 |
33675-33677 |
NN |
denotes |
6B |
T7711 |
33677-33678 |
-RRB- |
denotes |
) |
T7712 |
33678-33679 |
. |
denotes |
. |
T7713 |
33679-33823 |
sentence |
denotes |
This confirms the role of these brain areas as inferred from the mosaic expression and protein correlation analysis described above (Figure 4). |
T7714 |
33680-33684 |
DT |
denotes |
This |
T7715 |
33685-33693 |
VBZ |
denotes |
confirms |
T7716 |
33694-33697 |
DT |
denotes |
the |
T7717 |
33698-33702 |
NN |
denotes |
role |
T7718 |
33703-33705 |
IN |
denotes |
of |
T7719 |
33706-33711 |
DT |
denotes |
these |
T7720 |
33718-33723 |
NNS |
denotes |
areas |
T7721 |
33712-33717 |
NN |
denotes |
brain |
T7722 |
33724-33726 |
IN |
denotes |
as |
T7723 |
33727-33735 |
VBN |
denotes |
inferred |
T7724 |
33736-33740 |
IN |
denotes |
from |
T7725 |
33741-33744 |
DT |
denotes |
the |
T7726 |
33752-33762 |
NN |
denotes |
expression |
T7727 |
33745-33751 |
JJ |
denotes |
mosaic |
T7728 |
33763-33766 |
CC |
denotes |
and |
T7729 |
33767-33774 |
NN |
denotes |
protein |
T7730 |
33787-33795 |
NN |
denotes |
analysis |
T7731 |
33775-33786 |
NN |
denotes |
correlation |
T7732 |
33796-33805 |
VBN |
denotes |
described |
T7733 |
33806-33811 |
RB |
denotes |
above |
T7734 |
33812-33813 |
-LRB- |
denotes |
( |
T7735 |
33813-33819 |
NN |
denotes |
Figure |
T7736 |
33820-33821 |
CD |
denotes |
4 |
T7737 |
33821-33822 |
-RRB- |
denotes |
) |
T7738 |
33822-33823 |
. |
denotes |
. |
T7739 |
33823-34351 |
sentence |
denotes |
However, odor discrimination (measured by the discrimination index as in Figures 1, 2, and 4D) was as enhanced as in GluR-BΔFB mice (0.79 ± 0.05, mean ± SEM compared with 0.76 ± 0.02, p > 0.7, Figure 6C), and improved relative to GluR-B2lox controls (0.48 ± 0.06; Figure 6C; overall ANOVA: F(2,41) = 17.2, p < 10−5; post hoc Newman Keuls: p < 10−3), as expected if the enhanced discrimination phenotype is due to Ca2+-permeable AMPARs in the olfactory bulb and unaffected by GluR-B expression in piriform cortex or hippocampus. |
T7740 |
33824-33831 |
RB |
denotes |
However |
T7741 |
33919-33922 |
VBD |
denotes |
was |
T7742 |
33831-33833 |
, |
denotes |
, |
T7743 |
33833-33837 |
NN |
denotes |
odor |
T7744 |
33838-33852 |
NN |
denotes |
discrimination |
T7745 |
33853-33854 |
-LRB- |
denotes |
( |
T7746 |
33854-33862 |
VBN |
denotes |
measured |
T7747 |
33863-33865 |
IN |
denotes |
by |
T7748 |
33866-33869 |
DT |
denotes |
the |
T7749 |
33885-33890 |
NN |
denotes |
index |
T7750 |
33870-33884 |
NN |
denotes |
discrimination |
T7751 |
33891-33893 |
IN |
denotes |
as |
T7752 |
33894-33896 |
IN |
denotes |
in |
T7753 |
33897-33904 |
NNS |
denotes |
Figures |
T7754 |
33915-33917 |
NN |
denotes |
4D |
T7755 |
33905-33906 |
CD |
denotes |
1 |
T7756 |
33906-33908 |
, |
denotes |
, |
T7757 |
33908-33909 |
CD |
denotes |
2 |
T7758 |
33909-33911 |
, |
denotes |
, |
T7759 |
33911-33914 |
CC |
denotes |
and |
T7760 |
33917-33918 |
-RRB- |
denotes |
) |
T7761 |
33923-33925 |
RB |
denotes |
as |
T7762 |
33926-33934 |
VBN |
denotes |
enhanced |
T7763 |
33935-33937 |
IN |
denotes |
as |
T7764 |
33938-33940 |
IN |
denotes |
in |
T7765 |
33941-33945 |
NN |
denotes |
GluR |
T7766 |
33946-33950 |
NN |
denotes |
BΔFB |
T7767 |
33945-33946 |
HYPH |
denotes |
- |
T7768 |
33951-33955 |
NNS |
denotes |
mice |
T7769 |
33956-33957 |
-LRB- |
denotes |
( |
T7770 |
34024-34026 |
NN |
denotes |
6C |
T7771 |
33957-33961 |
CD |
denotes |
0.79 |
T7772 |
33964-33968 |
CD |
denotes |
0.05 |
T7773 |
33962-33963 |
SYM |
denotes |
± |
T7774 |
33968-33970 |
, |
denotes |
, |
T7775 |
33970-33974 |
NN |
denotes |
mean |
T7776 |
33977-33980 |
NN |
denotes |
SEM |
T7777 |
33975-33976 |
SYM |
denotes |
± |
T7778 |
33981-33989 |
VBN |
denotes |
compared |
T7779 |
33990-33994 |
IN |
denotes |
with |
T7780 |
33995-33999 |
CD |
denotes |
0.76 |
T7781 |
34002-34006 |
CD |
denotes |
0.02 |
T7782 |
34000-34001 |
SYM |
denotes |
± |
T7783 |
34006-34008 |
, |
denotes |
, |
T7784 |
34008-34009 |
NN |
denotes |
p |
T7785 |
34012-34015 |
CD |
denotes |
0.7 |
T7786 |
34010-34011 |
SYM |
denotes |
> |
T7787 |
34015-34017 |
, |
denotes |
, |
T7788 |
34017-34023 |
NN |
denotes |
Figure |
T7789 |
34026-34027 |
-RRB- |
denotes |
) |
T7790 |
34027-34029 |
, |
denotes |
, |
T7791 |
34029-34032 |
CC |
denotes |
and |
T7792 |
34033-34041 |
VBN |
denotes |
improved |
T7793 |
34042-34050 |
JJ |
denotes |
relative |
T7794 |
34051-34053 |
IN |
denotes |
to |
T7795 |
34054-34058 |
NN |
denotes |
GluR |
T7796 |
34059-34064 |
NN |
denotes |
B2lox |
T7797 |
34058-34059 |
HYPH |
denotes |
- |
T7798 |
34065-34073 |
NNS |
denotes |
controls |
T7799 |
34074-34075 |
-LRB- |
denotes |
( |
T7800 |
34095-34097 |
NN |
denotes |
6C |
T7801 |
34075-34079 |
CD |
denotes |
0.48 |
T7802 |
34082-34086 |
CD |
denotes |
0.06 |
T7803 |
34080-34081 |
SYM |
denotes |
± |
T7804 |
34086-34087 |
: |
denotes |
; |
T7805 |
34088-34094 |
NN |
denotes |
Figure |
T7806 |
34097-34098 |
: |
denotes |
; |
T7807 |
34099-34106 |
JJ |
denotes |
overall |
T7808 |
34107-34112 |
NN |
denotes |
ANOVA |
T7809 |
34134-34136 |
CD |
denotes |
10 |
T7810 |
34112-34114 |
: |
denotes |
: |
T7811 |
34114-34115 |
NN |
denotes |
F |
T7812 |
34124-34128 |
CD |
denotes |
17.2 |
T7813 |
34115-34116 |
-LRB- |
denotes |
( |
T7814 |
34116-34117 |
CD |
denotes |
2 |
T7815 |
34117-34118 |
, |
denotes |
, |
T7816 |
34118-34120 |
CD |
denotes |
41 |
T7817 |
34120-34121 |
-RRB- |
denotes |
) |
T7818 |
34122-34123 |
SYM |
denotes |
= |
T7819 |
34128-34130 |
, |
denotes |
, |
T7820 |
34130-34131 |
NN |
denotes |
p |
T7821 |
34132-34133 |
SYM |
denotes |
< |
T7822 |
34136-34137 |
SYM |
denotes |
− |
T7823 |
34137-34138 |
CD |
denotes |
5 |
T7824 |
34138-34139 |
: |
denotes |
; |
T7825 |
34140-34144 |
FW |
denotes |
post |
T7826 |
34145-34148 |
FW |
denotes |
hoc |
T7827 |
34156-34161 |
NNP |
denotes |
Keuls |
T7828 |
34149-34155 |
NNP |
denotes |
Newman |
T7829 |
34170-34171 |
CD |
denotes |
3 |
T7830 |
34161-34163 |
: |
denotes |
: |
T7831 |
34163-34164 |
NN |
denotes |
p |
T7832 |
34165-34166 |
SYM |
denotes |
< |
T7833 |
34167-34169 |
CD |
denotes |
10 |
T7834 |
34169-34170 |
SYM |
denotes |
− |
T7835 |
34171-34172 |
-RRB- |
denotes |
) |
T7836 |
34172-34174 |
, |
denotes |
, |
T7837 |
34174-34176 |
IN |
denotes |
as |
T7838 |
34177-34185 |
VBN |
denotes |
expected |
T7839 |
34186-34188 |
IN |
denotes |
if |
T7840 |
34227-34229 |
VBZ |
denotes |
is |
T7841 |
34189-34192 |
DT |
denotes |
the |
T7842 |
34217-34226 |
NN |
denotes |
phenotype |
T7843 |
34193-34201 |
VBN |
denotes |
enhanced |
T7844 |
34202-34216 |
NN |
denotes |
discrimination |
T7845 |
34230-34233 |
IN |
denotes |
due |
T7846 |
34234-34236 |
IN |
denotes |
to |
T7847 |
34237-34240 |
NN |
denotes |
Ca2 |
T7848 |
34242-34251 |
JJ |
denotes |
permeable |
T7849 |
34240-34241 |
SYM |
denotes |
+ |
T7850 |
34241-34242 |
HYPH |
denotes |
- |
T7851 |
34252-34258 |
NNS |
denotes |
AMPARs |
T7852 |
34259-34261 |
IN |
denotes |
in |
T7853 |
34262-34265 |
DT |
denotes |
the |
T7854 |
34276-34280 |
NN |
denotes |
bulb |
T7855 |
34266-34275 |
JJ |
denotes |
olfactory |
T7856 |
34281-34284 |
CC |
denotes |
and |
T7857 |
34285-34295 |
JJ |
denotes |
unaffected |
T7858 |
34296-34298 |
IN |
denotes |
by |
T7859 |
34299-34303 |
NN |
denotes |
GluR |
T7860 |
34304-34305 |
NN |
denotes |
B |
T7861 |
34303-34304 |
HYPH |
denotes |
- |
T7862 |
34306-34316 |
NN |
denotes |
expression |
T7863 |
34317-34319 |
IN |
denotes |
in |
T7864 |
34320-34328 |
JJ |
denotes |
piriform |
T7865 |
34329-34335 |
NN |
denotes |
cortex |
T7866 |
34336-34338 |
CC |
denotes |
or |
T7867 |
34339-34350 |
NN |
denotes |
hippocampus |
T7868 |
34350-34351 |
. |
denotes |
. |
T7869 |
34351-35806 |
sentence |
denotes |
Figure 6 GluR-B Expression in Hippocampus and Forebrain Partially Rescues the Memory Deficit of GluR-BΔFB Mice
(A) Olfactory memory experiments as in Figure 2 were performed with GluR-BRescue. Individual mice are indicated: control GluR-B2lox with black circles, GluR-BΔFB with red triangles, GluR-BRescue with green squares. Data were combined from Figure 3 and 4 (open symbols) and an additional experiment with four GluR-BΔFB, three littermate controls, and eight GluR-BRescue (shaded symbols).
(B) Cumulative histogram of the memory performance. Memory performance is indicated as a stepped line. The sigmoidal fit is indicated as a continuous line. The predicted rescue on the basis of the extent of transgenic GFPGluR-B expression (Figure 5D) and the correlation between memory and GluR-B levels in piriform cortex (9.1 ± 2.5% increase in memory for 10% increase in protein, Figure 4D) is shown in blue. Note that the predicted rescue is in perfect numerical correspondence to the memory performance of GluR-BRescue mice.
(C) The discrimination index was calculated as in Figures 1E, 2C, and 4D (last 100 trials of the mixture discrimination task) for GluRBRescue (n = 8), GluR-BΔFB (n = 22), and control (n = 14) animals. Hence, transgenic GluR-B expression, specifically in the piriform cortex and hippocampus in the GluR-B knockout background, rescues the odor memory deficit but leaves enhanced olfactory discrimination and learning unaltered. |
T7870 |
35582-35587 |
RB |
denotes |
Hence |
T7871 |
35706-35713 |
VBZ |
denotes |
rescues |
T7872 |
35587-35589 |
, |
denotes |
, |
T7873 |
35589-35599 |
JJ |
denotes |
transgenic |
T7874 |
35607-35617 |
NN |
denotes |
expression |
T7875 |
35600-35604 |
NN |
denotes |
GluR |
T7876 |
35605-35606 |
NN |
denotes |
B |
T7877 |
35604-35605 |
HYPH |
denotes |
- |
T7878 |
35617-35619 |
, |
denotes |
, |
T7879 |
35619-35631 |
RB |
denotes |
specifically |
T7880 |
35632-35634 |
IN |
denotes |
in |
T7881 |
35635-35638 |
DT |
denotes |
the |
T7882 |
35648-35654 |
NN |
denotes |
cortex |
T7883 |
35639-35647 |
JJ |
denotes |
piriform |
T7884 |
35655-35658 |
CC |
denotes |
and |
T7885 |
35659-35670 |
NN |
denotes |
hippocampus |
T7886 |
35671-35673 |
IN |
denotes |
in |
T7887 |
35674-35677 |
DT |
denotes |
the |
T7888 |
35694-35704 |
NN |
denotes |
background |
T7889 |
35678-35682 |
NN |
denotes |
GluR |
T7890 |
35683-35684 |
NN |
denotes |
B |
T7891 |
35682-35683 |
HYPH |
denotes |
- |
T7892 |
35685-35693 |
NN |
denotes |
knockout |
T7893 |
35704-35706 |
, |
denotes |
, |
T7894 |
35714-35717 |
DT |
denotes |
the |
T7895 |
35730-35737 |
NN |
denotes |
deficit |
T7896 |
35718-35722 |
NN |
denotes |
odor |
T7897 |
35723-35729 |
NN |
denotes |
memory |
T7898 |
35738-35741 |
CC |
denotes |
but |
T7899 |
35742-35748 |
VBZ |
denotes |
leaves |
T7900 |
35749-35757 |
VBN |
denotes |
enhanced |
T7901 |
35768-35782 |
NN |
denotes |
discrimination |
T7902 |
35758-35767 |
JJ |
denotes |
olfactory |
T7903 |
35783-35786 |
CC |
denotes |
and |
T7904 |
35787-35795 |
NN |
denotes |
learning |
T7905 |
35796-35805 |
JJ |
denotes |
unaltered |
T7906 |
35805-35806 |
. |
denotes |
. |
T8327 |
35819-35823 |
RB |
denotes |
Here |
T8328 |
35827-35834 |
VBP |
denotes |
present |
T8329 |
35824-35826 |
PRP |
denotes |
we |
T8330 |
35835-35846 |
JJ |
denotes |
mechanistic |
T8331 |
35859-35870 |
NNS |
denotes |
dissections |
T8332 |
35847-35850 |
CC |
denotes |
and |
T8333 |
35851-35858 |
JJ |
denotes |
spatial |
T8334 |
35871-35873 |
IN |
denotes |
of |
T8335 |
35874-35883 |
JJ |
denotes |
olfactory |
T8336 |
35884-35898 |
NN |
denotes |
discrimination |
T8337 |
35898-35900 |
, |
denotes |
, |
T8338 |
35900-35908 |
NN |
denotes |
learning |
T8339 |
35908-35910 |
, |
denotes |
, |
T8340 |
35910-35913 |
CC |
denotes |
and |
T8341 |
35914-35920 |
NN |
denotes |
memory |
T8342 |
35920-35921 |
. |
denotes |
. |
T8343 |
35921-36253 |
sentence |
denotes |
We employed gene-targeted and transgenic mice with region-specific expression to demonstrate that a change in GluR-B-mediated properties of AMPA channels in αCaMKII-expressing neurons of mouse forebrain, including olfactory bulb mitral and granule cells, enhances olfactory discrimination and learning but impairs olfactory memory. |
T8344 |
35922-35924 |
PRP |
denotes |
We |
T8345 |
35925-35933 |
VBD |
denotes |
employed |
T8346 |
35934-35938 |
NN |
denotes |
gene |
T8347 |
35939-35947 |
VBN |
denotes |
targeted |
T8348 |
35938-35939 |
HYPH |
denotes |
- |
T8349 |
35963-35967 |
NNS |
denotes |
mice |
T8350 |
35948-35951 |
CC |
denotes |
and |
T8351 |
35952-35962 |
JJ |
denotes |
transgenic |
T8352 |
35968-35972 |
IN |
denotes |
with |
T8353 |
35973-35979 |
NN |
denotes |
region |
T8354 |
35980-35988 |
JJ |
denotes |
specific |
T8355 |
35979-35980 |
HYPH |
denotes |
- |
T8356 |
35989-35999 |
NN |
denotes |
expression |
T8357 |
36000-36002 |
TO |
denotes |
to |
T8358 |
36003-36014 |
VB |
denotes |
demonstrate |
T8359 |
36015-36019 |
IN |
denotes |
that |
T8360 |
36177-36185 |
VBZ |
denotes |
enhances |
T8361 |
36020-36021 |
DT |
denotes |
a |
T8362 |
36022-36028 |
NN |
denotes |
change |
T8363 |
36029-36031 |
IN |
denotes |
in |
T8364 |
36032-36036 |
NN |
denotes |
GluR |
T8365 |
36037-36038 |
NN |
denotes |
B |
T8366 |
36036-36037 |
HYPH |
denotes |
- |
T8367 |
36039-36047 |
VBN |
denotes |
mediated |
T8368 |
36038-36039 |
HYPH |
denotes |
- |
T8369 |
36048-36058 |
NNS |
denotes |
properties |
T8370 |
36059-36061 |
IN |
denotes |
of |
T8371 |
36062-36066 |
NN |
denotes |
AMPA |
T8372 |
36067-36075 |
NNS |
denotes |
channels |
T8373 |
36076-36078 |
IN |
denotes |
in |
T8374 |
36079-36086 |
NN |
denotes |
αCaMKII |
T8375 |
36087-36097 |
VBG |
denotes |
expressing |
T8376 |
36086-36087 |
HYPH |
denotes |
- |
T8377 |
36098-36105 |
NNS |
denotes |
neurons |
T8378 |
36106-36108 |
IN |
denotes |
of |
T8379 |
36109-36114 |
NN |
denotes |
mouse |
T8380 |
36115-36124 |
NN |
denotes |
forebrain |
T8381 |
36124-36126 |
, |
denotes |
, |
T8382 |
36126-36135 |
VBG |
denotes |
including |
T8383 |
36136-36145 |
JJ |
denotes |
olfactory |
T8384 |
36146-36150 |
NN |
denotes |
bulb |
T8385 |
36170-36175 |
NNS |
denotes |
cells |
T8386 |
36151-36157 |
JJ |
denotes |
mitral |
T8387 |
36158-36161 |
CC |
denotes |
and |
T8388 |
36162-36169 |
NN |
denotes |
granule |
T8389 |
36175-36177 |
, |
denotes |
, |
T8390 |
36186-36195 |
JJ |
denotes |
olfactory |
T8391 |
36196-36210 |
NN |
denotes |
discrimination |
T8392 |
36211-36214 |
CC |
denotes |
and |
T8393 |
36215-36223 |
NN |
denotes |
learning |
T8394 |
36224-36227 |
CC |
denotes |
but |
T8395 |
36228-36235 |
VBZ |
denotes |
impairs |
T8396 |
36236-36245 |
JJ |
denotes |
olfactory |
T8397 |
36246-36252 |
NN |
denotes |
memory |
T8398 |
36252-36253 |
. |
denotes |
. |
T8399 |
36253-36421 |
sentence |
denotes |
These pertinent olfactory behaviors were assessed in a go/no-go operant conditioning task, which provides a quantitative, robust, and reproducible behavioral tool [3]. |
T8400 |
36254-36259 |
DT |
denotes |
These |
T8401 |
36280-36289 |
NNS |
denotes |
behaviors |
T8402 |
36260-36269 |
JJ |
denotes |
pertinent |
T8403 |
36270-36279 |
JJ |
denotes |
olfactory |
T8404 |
36295-36303 |
VBN |
denotes |
assessed |
T8405 |
36290-36294 |
VBD |
denotes |
were |
T8406 |
36304-36306 |
IN |
denotes |
in |
T8407 |
36307-36308 |
DT |
denotes |
a |
T8408 |
36339-36343 |
NN |
denotes |
task |
T8409 |
36309-36311 |
NN |
denotes |
go |
T8410 |
36311-36312 |
HYPH |
denotes |
/ |
T8411 |
36312-36314 |
DT |
denotes |
no |
T8412 |
36315-36317 |
NN |
denotes |
go |
T8413 |
36314-36315 |
HYPH |
denotes |
- |
T8414 |
36318-36325 |
NN |
denotes |
operant |
T8415 |
36326-36338 |
NN |
denotes |
conditioning |
T8416 |
36343-36345 |
, |
denotes |
, |
T8417 |
36345-36350 |
WDT |
denotes |
which |
T8418 |
36351-36359 |
VBZ |
denotes |
provides |
T8419 |
36360-36361 |
DT |
denotes |
a |
T8420 |
36412-36416 |
NN |
denotes |
tool |
T8421 |
36362-36374 |
JJ |
denotes |
quantitative |
T8422 |
36374-36376 |
, |
denotes |
, |
T8423 |
36376-36382 |
JJ |
denotes |
robust |
T8424 |
36382-36384 |
, |
denotes |
, |
T8425 |
36384-36387 |
CC |
denotes |
and |
T8426 |
36388-36400 |
JJ |
denotes |
reproducible |
T8427 |
36401-36411 |
JJ |
denotes |
behavioral |
T8428 |
36417-36418 |
-LRB- |
denotes |
[ |
T8429 |
36418-36419 |
CD |
denotes |
3 |
T8430 |
36419-36420 |
-RRB- |
denotes |
] |
T8431 |
36420-36421 |
. |
denotes |
. |
T8432 |
36421-36542 |
sentence |
denotes |
We observed among individual mice a striking variability in olfactory memory performance but not in odor discrimination. |
T8433 |
36422-36424 |
PRP |
denotes |
We |
T8434 |
36425-36433 |
VBD |
denotes |
observed |
T8435 |
36434-36439 |
IN |
denotes |
among |
T8436 |
36440-36450 |
JJ |
denotes |
individual |
T8437 |
36451-36455 |
NNS |
denotes |
mice |
T8438 |
36456-36457 |
DT |
denotes |
a |
T8439 |
36467-36478 |
NN |
denotes |
variability |
T8440 |
36458-36466 |
JJ |
denotes |
striking |
T8441 |
36479-36481 |
IN |
denotes |
in |
T8442 |
36482-36491 |
JJ |
denotes |
olfactory |
T8443 |
36492-36498 |
NN |
denotes |
memory |
T8444 |
36499-36510 |
NN |
denotes |
performance |
T8445 |
36511-36514 |
CC |
denotes |
but |
T8446 |
36515-36518 |
RB |
denotes |
not |
T8447 |
36519-36521 |
IN |
denotes |
in |
T8448 |
36522-36526 |
NN |
denotes |
odor |
T8449 |
36527-36541 |
NN |
denotes |
discrimination |
T8450 |
36541-36542 |
. |
denotes |
. |
T8451 |
36542-36878 |
sentence |
denotes |
This variability could be traced to epigenetic variability in the transgenic expression of Cre-recombinase, which mediated recombination within loxP-flanked segments of gene-targeted alleles for the dominant AMPAR subunit GluR-B, and hence operated the switch in AMPAR properties toward GluR-B ablation and increased Ca2+ permeability. |
T8452 |
36543-36547 |
DT |
denotes |
This |
T8453 |
36548-36559 |
NN |
denotes |
variability |
T8454 |
36569-36575 |
VBN |
denotes |
traced |
T8455 |
36560-36565 |
MD |
denotes |
could |
T8456 |
36566-36568 |
VB |
denotes |
be |
T8457 |
36576-36578 |
IN |
denotes |
to |
T8458 |
36579-36589 |
JJ |
denotes |
epigenetic |
T8459 |
36590-36601 |
NN |
denotes |
variability |
T8460 |
36602-36604 |
IN |
denotes |
in |
T8461 |
36605-36608 |
DT |
denotes |
the |
T8462 |
36620-36630 |
NN |
denotes |
expression |
T8463 |
36609-36619 |
JJ |
denotes |
transgenic |
T8464 |
36631-36633 |
IN |
denotes |
of |
T8465 |
36634-36637 |
NN |
denotes |
Cre |
T8466 |
36638-36649 |
NN |
denotes |
recombinase |
T8467 |
36637-36638 |
HYPH |
denotes |
- |
T8468 |
36649-36651 |
, |
denotes |
, |
T8469 |
36651-36656 |
WDT |
denotes |
which |
T8470 |
36657-36665 |
VBD |
denotes |
mediated |
T8471 |
36666-36679 |
NN |
denotes |
recombination |
T8472 |
36680-36686 |
IN |
denotes |
within |
T8473 |
36687-36691 |
NN |
denotes |
loxP |
T8474 |
36692-36699 |
VBN |
denotes |
flanked |
T8475 |
36691-36692 |
HYPH |
denotes |
- |
T8476 |
36700-36708 |
NNS |
denotes |
segments |
T8477 |
36709-36711 |
IN |
denotes |
of |
T8478 |
36712-36716 |
NN |
denotes |
gene |
T8479 |
36717-36725 |
VBN |
denotes |
targeted |
T8480 |
36716-36717 |
HYPH |
denotes |
- |
T8481 |
36726-36733 |
NNS |
denotes |
alleles |
T8482 |
36734-36737 |
IN |
denotes |
for |
T8483 |
36738-36741 |
DT |
denotes |
the |
T8484 |
36757-36764 |
NN |
denotes |
subunit |
T8485 |
36742-36750 |
JJ |
denotes |
dominant |
T8486 |
36751-36756 |
NN |
denotes |
AMPAR |
T8487 |
36765-36769 |
NN |
denotes |
GluR |
T8488 |
36770-36771 |
NN |
denotes |
B |
T8489 |
36769-36770 |
HYPH |
denotes |
- |
T8490 |
36771-36773 |
, |
denotes |
, |
T8491 |
36773-36776 |
CC |
denotes |
and |
T8492 |
36777-36782 |
RB |
denotes |
hence |
T8493 |
36783-36791 |
VBD |
denotes |
operated |
T8494 |
36792-36795 |
DT |
denotes |
the |
T8495 |
36796-36802 |
NN |
denotes |
switch |
T8496 |
36803-36805 |
IN |
denotes |
in |
T8497 |
36806-36811 |
NN |
denotes |
AMPAR |
T8498 |
36812-36822 |
NNS |
denotes |
properties |
T8499 |
36823-36829 |
IN |
denotes |
toward |
T8500 |
36830-36834 |
NN |
denotes |
GluR |
T8501 |
36835-36836 |
NN |
denotes |
B |
T8502 |
36834-36835 |
HYPH |
denotes |
- |
T8503 |
36837-36845 |
NN |
denotes |
ablation |
T8504 |
36846-36849 |
CC |
denotes |
and |
T8505 |
36850-36859 |
VBN |
denotes |
increased |
T8506 |
36865-36877 |
NN |
denotes |
permeability |
T8507 |
36860-36863 |
NN |
denotes |
Ca2 |
T8508 |
36863-36864 |
SYM |
denotes |
+ |
T8509 |
36877-36878 |
. |
denotes |
. |
T8510 |
36878-37080 |
sentence |
denotes |
In contrast to variable memory, olfactory discrimination and learning performances appeared already saturated by even moderate extents of Cre expression, and hence moderate changes in AMPAR properties. |
T8511 |
36879-36881 |
IN |
denotes |
In |
T8512 |
36962-36970 |
VBD |
denotes |
appeared |
T8513 |
36882-36890 |
NN |
denotes |
contrast |
T8514 |
36891-36893 |
IN |
denotes |
to |
T8515 |
36894-36902 |
JJ |
denotes |
variable |
T8516 |
36903-36909 |
NN |
denotes |
memory |
T8517 |
36909-36911 |
, |
denotes |
, |
T8518 |
36911-36920 |
JJ |
denotes |
olfactory |
T8519 |
36921-36935 |
NN |
denotes |
discrimination |
T8520 |
36949-36961 |
NNS |
denotes |
performances |
T8521 |
36936-36939 |
CC |
denotes |
and |
T8522 |
36940-36948 |
NN |
denotes |
learning |
T8523 |
36971-36978 |
RB |
denotes |
already |
T8524 |
36979-36988 |
JJ |
denotes |
saturated |
T8525 |
36989-36991 |
IN |
denotes |
by |
T8526 |
36992-36996 |
RB |
denotes |
even |
T8527 |
37006-37013 |
NNS |
denotes |
extents |
T8528 |
36997-37005 |
JJ |
denotes |
moderate |
T8529 |
37014-37016 |
IN |
denotes |
of |
T8530 |
37017-37020 |
NN |
denotes |
Cre |
T8531 |
37021-37031 |
NN |
denotes |
expression |
T8532 |
37031-37033 |
, |
denotes |
, |
T8533 |
37033-37036 |
CC |
denotes |
and |
T8534 |
37037-37042 |
RB |
denotes |
hence |
T8535 |
37052-37059 |
NNS |
denotes |
changes |
T8536 |
37043-37051 |
JJ |
denotes |
moderate |
T8537 |
37060-37062 |
IN |
denotes |
in |
T8538 |
37063-37068 |
NN |
denotes |
AMPAR |
T8539 |
37069-37079 |
NNS |
denotes |
properties |
T8540 |
37079-37080 |
. |
denotes |
. |
T8541 |
37080-37333 |
sentence |
denotes |
The subsequent transgene-driven re-introduction of GluR-B, specifically in piriform cortex and hippocampus, reversed the Cre-induced loss of GluR-B and partially rescued the odor memory deficit, but left unaltered the enhanced olfactory discrimination. |
T8542 |
37081-37084 |
DT |
denotes |
The |
T8543 |
37113-37128 |
NN |
denotes |
re-introduction |
T8544 |
37085-37095 |
JJ |
denotes |
subsequent |
T8545 |
37096-37105 |
NN |
denotes |
transgene |
T8546 |
37106-37112 |
VBN |
denotes |
driven |
T8547 |
37105-37106 |
HYPH |
denotes |
- |
T8548 |
37189-37197 |
VBD |
denotes |
reversed |
T8549 |
37129-37131 |
IN |
denotes |
of |
T8550 |
37132-37136 |
NN |
denotes |
GluR |
T8551 |
37137-37138 |
NN |
denotes |
B |
T8552 |
37136-37137 |
HYPH |
denotes |
- |
T8553 |
37138-37140 |
, |
denotes |
, |
T8554 |
37140-37152 |
RB |
denotes |
specifically |
T8555 |
37153-37155 |
IN |
denotes |
in |
T8556 |
37156-37164 |
JJ |
denotes |
piriform |
T8557 |
37165-37171 |
NN |
denotes |
cortex |
T8558 |
37172-37175 |
CC |
denotes |
and |
T8559 |
37176-37187 |
NN |
denotes |
hippocampus |
T8560 |
37187-37189 |
, |
denotes |
, |
T8561 |
37198-37201 |
DT |
denotes |
the |
T8562 |
37214-37218 |
NN |
denotes |
loss |
T8563 |
37202-37205 |
NN |
denotes |
Cre |
T8564 |
37206-37213 |
VBN |
denotes |
induced |
T8565 |
37205-37206 |
HYPH |
denotes |
- |
T8566 |
37219-37221 |
IN |
denotes |
of |
T8567 |
37222-37226 |
NN |
denotes |
GluR |
T8568 |
37227-37228 |
NN |
denotes |
B |
T8569 |
37226-37227 |
HYPH |
denotes |
- |
T8570 |
37229-37232 |
CC |
denotes |
and |
T8571 |
37233-37242 |
RB |
denotes |
partially |
T8572 |
37243-37250 |
VBD |
denotes |
rescued |
T8573 |
37251-37254 |
DT |
denotes |
the |
T8574 |
37267-37274 |
NN |
denotes |
deficit |
T8575 |
37255-37259 |
NN |
denotes |
odor |
T8576 |
37260-37266 |
NN |
denotes |
memory |
T8577 |
37274-37276 |
, |
denotes |
, |
T8578 |
37276-37279 |
CC |
denotes |
but |
T8579 |
37280-37284 |
VBD |
denotes |
left |
T8580 |
37285-37294 |
JJ |
denotes |
unaltered |
T8581 |
37295-37298 |
DT |
denotes |
the |
T8582 |
37318-37332 |
NN |
denotes |
discrimination |
T8583 |
37299-37307 |
VBN |
denotes |
enhanced |
T8584 |
37308-37317 |
JJ |
denotes |
olfactory |
T8585 |
37332-37333 |
. |
denotes |
. |
T8586 |
37333-37621 |
sentence |
denotes |
In a nutshell, we conclude that olfactory discrimination is enhanced by an increase in AMPAR-mediated Ca2+ permeability within the olfactory bulb, whereas olfactory memory becomes impaired upon genetically induced GluR-B ablation in higher brain centers, specifically in piriform cortex. |
T8587 |
37334-37336 |
IN |
denotes |
In |
T8588 |
37352-37360 |
VBP |
denotes |
conclude |
T8589 |
37337-37338 |
DT |
denotes |
a |
T8590 |
37339-37347 |
NN |
denotes |
nutshell |
T8591 |
37347-37349 |
, |
denotes |
, |
T8592 |
37349-37351 |
PRP |
denotes |
we |
T8593 |
37361-37365 |
IN |
denotes |
that |
T8594 |
37394-37402 |
VBN |
denotes |
enhanced |
T8595 |
37366-37375 |
JJ |
denotes |
olfactory |
T8596 |
37376-37390 |
NN |
denotes |
discrimination |
T8597 |
37391-37393 |
VBZ |
denotes |
is |
T8598 |
37403-37405 |
IN |
denotes |
by |
T8599 |
37406-37408 |
DT |
denotes |
an |
T8600 |
37409-37417 |
NN |
denotes |
increase |
T8601 |
37418-37420 |
IN |
denotes |
in |
T8602 |
37421-37426 |
NN |
denotes |
AMPAR |
T8603 |
37427-37435 |
VBN |
denotes |
mediated |
T8604 |
37426-37427 |
HYPH |
denotes |
- |
T8605 |
37441-37453 |
NN |
denotes |
permeability |
T8606 |
37436-37439 |
NN |
denotes |
Ca2 |
T8607 |
37439-37440 |
SYM |
denotes |
+ |
T8608 |
37454-37460 |
IN |
denotes |
within |
T8609 |
37461-37464 |
DT |
denotes |
the |
T8610 |
37475-37479 |
NN |
denotes |
bulb |
T8611 |
37465-37474 |
JJ |
denotes |
olfactory |
T8612 |
37479-37481 |
, |
denotes |
, |
T8613 |
37481-37488 |
IN |
denotes |
whereas |
T8614 |
37506-37513 |
VBZ |
denotes |
becomes |
T8615 |
37489-37498 |
JJ |
denotes |
olfactory |
T8616 |
37499-37505 |
NN |
denotes |
memory |
T8617 |
37514-37522 |
JJ |
denotes |
impaired |
T8618 |
37523-37527 |
IN |
denotes |
upon |
T8619 |
37528-37539 |
RB |
denotes |
genetically |
T8620 |
37540-37547 |
VBN |
denotes |
induced |
T8621 |
37555-37563 |
NN |
denotes |
ablation |
T8622 |
37548-37552 |
NN |
denotes |
GluR |
T8623 |
37553-37554 |
NN |
denotes |
B |
T8624 |
37552-37553 |
HYPH |
denotes |
- |
T8625 |
37564-37566 |
IN |
denotes |
in |
T8626 |
37567-37573 |
JJR |
denotes |
higher |
T8627 |
37580-37587 |
NNS |
denotes |
centers |
T8628 |
37574-37579 |
NN |
denotes |
brain |
T8629 |
37587-37589 |
, |
denotes |
, |
T8630 |
37589-37601 |
RB |
denotes |
specifically |
T8631 |
37602-37604 |
IN |
denotes |
in |
T8632 |
37605-37613 |
JJ |
denotes |
piriform |
T8633 |
37614-37620 |
NN |
denotes |
cortex |
T8634 |
37620-37621 |
. |
denotes |
. |
T8822 |
37623-37632 |
JJ |
denotes |
Olfactory |
T8823 |
37633-37647 |
NN |
denotes |
Discrimination |
T8824 |
37651-37660 |
VBN |
denotes |
Increased |
T8825 |
37648-37650 |
VBZ |
denotes |
Is |
T8826 |
37661-37663 |
IN |
denotes |
in |
T8827 |
37664-37668 |
NNS |
denotes |
Mice |
T8828 |
37669-37673 |
IN |
denotes |
with |
T8829 |
37674-37683 |
NN |
denotes |
Forebrain |
T8830 |
37684-37692 |
JJ |
denotes |
Specific |
T8831 |
37683-37684 |
HYPH |
denotes |
- |
T8832 |
37700-37708 |
NN |
denotes |
Ablation |
T8833 |
37693-37697 |
NN |
denotes |
GluR |
T8834 |
37698-37699 |
NN |
denotes |
B |
T8835 |
37697-37698 |
HYPH |
denotes |
- |
T8836 |
37709-37711 |
CC |
denotes |
or |
T8837 |
37712-37716 |
NN |
denotes |
GluR |
T8838 |
37719-37720 |
NN |
denotes |
Q |
T8839 |
37716-37717 |
HYPH |
denotes |
- |
T8840 |
37717-37718 |
NN |
denotes |
B |
T8841 |
37718-37719 |
-LRB- |
denotes |
( |
T8842 |
37722-37732 |
NN |
denotes |
Expression |
T8843 |
37720-37721 |
-RRB- |
denotes |
) |
T8844 |
37732-37867 |
sentence |
denotes |
Both forebrain-specific GluR-B(Q) expression and GluR-B depletion led to increased olfactory learning and discrimination capabilities. |
T8845 |
37733-37737 |
CC |
denotes |
Both |
T8846 |
37767-37777 |
NN |
denotes |
expression |
T8847 |
37738-37747 |
NN |
denotes |
forebrain |
T8848 |
37748-37756 |
JJ |
denotes |
specific |
T8849 |
37747-37748 |
HYPH |
denotes |
- |
T8850 |
37757-37761 |
NN |
denotes |
GluR |
T8851 |
37764-37765 |
NN |
denotes |
Q |
T8852 |
37761-37762 |
HYPH |
denotes |
- |
T8853 |
37762-37763 |
NN |
denotes |
B |
T8854 |
37763-37764 |
-LRB- |
denotes |
( |
T8855 |
37765-37766 |
-RRB- |
denotes |
) |
T8856 |
37799-37802 |
VBD |
denotes |
led |
T8857 |
37778-37781 |
CC |
denotes |
and |
T8858 |
37782-37786 |
NN |
denotes |
GluR |
T8859 |
37787-37788 |
NN |
denotes |
B |
T8860 |
37786-37787 |
HYPH |
denotes |
- |
T8861 |
37789-37798 |
NN |
denotes |
depletion |
T8862 |
37803-37805 |
IN |
denotes |
to |
T8863 |
37806-37815 |
VBN |
denotes |
increased |
T8864 |
37854-37866 |
NNS |
denotes |
capabilities |
T8865 |
37816-37825 |
JJ |
denotes |
olfactory |
T8866 |
37826-37834 |
NN |
denotes |
learning |
T8867 |
37835-37838 |
CC |
denotes |
and |
T8868 |
37839-37853 |
NN |
denotes |
discrimination |
T8869 |
37866-37867 |
. |
denotes |
. |
T8870 |
37867-38093 |
sentence |
denotes |
This was rather pronounced for GluR-B(Q)-expressing mice, consistent with the overall stronger phenotypic consequences in comparison to GluR-B depletion, both when forebrain-selective ([58], and this study) or global [53,60]. |
T8871 |
37868-37872 |
DT |
denotes |
This |
T8872 |
37873-37876 |
VBD |
denotes |
was |
T8873 |
37877-37883 |
RB |
denotes |
rather |
T8874 |
37884-37894 |
JJ |
denotes |
pronounced |
T8875 |
37895-37898 |
IN |
denotes |
for |
T8876 |
37899-37903 |
NN |
denotes |
GluR |
T8877 |
37906-37907 |
NN |
denotes |
Q |
T8878 |
37903-37904 |
HYPH |
denotes |
- |
T8879 |
37904-37905 |
NN |
denotes |
B |
T8880 |
37905-37906 |
-LRB- |
denotes |
( |
T8881 |
37909-37919 |
VBG |
denotes |
expressing |
T8882 |
37907-37908 |
-RRB- |
denotes |
) |
T8883 |
37908-37909 |
HYPH |
denotes |
- |
T8884 |
37920-37924 |
NNS |
denotes |
mice |
T8885 |
37924-37926 |
, |
denotes |
, |
T8886 |
37926-37936 |
JJ |
denotes |
consistent |
T8887 |
37937-37941 |
IN |
denotes |
with |
T8888 |
37942-37945 |
DT |
denotes |
the |
T8889 |
37974-37986 |
NNS |
denotes |
consequences |
T8890 |
37946-37953 |
JJ |
denotes |
overall |
T8891 |
37954-37962 |
JJR |
denotes |
stronger |
T8892 |
37963-37973 |
JJ |
denotes |
phenotypic |
T8893 |
37987-37989 |
IN |
denotes |
in |
T8894 |
37990-38000 |
NN |
denotes |
comparison |
T8895 |
38001-38003 |
IN |
denotes |
to |
T8896 |
38004-38008 |
NN |
denotes |
GluR |
T8897 |
38009-38010 |
NN |
denotes |
B |
T8898 |
38008-38009 |
HYPH |
denotes |
- |
T8899 |
38011-38020 |
NN |
denotes |
depletion |
T8900 |
38020-38022 |
, |
denotes |
, |
T8901 |
38022-38026 |
CC |
denotes |
both |
T8902 |
38042-38051 |
JJ |
denotes |
selective |
T8903 |
38027-38031 |
WRB |
denotes |
when |
T8904 |
38032-38041 |
NN |
denotes |
forebrain |
T8905 |
38041-38042 |
HYPH |
denotes |
- |
T8906 |
38052-38053 |
-LRB- |
denotes |
( |
T8907 |
38054-38056 |
CD |
denotes |
58 |
T8908 |
38053-38054 |
-LRB- |
denotes |
[ |
T8909 |
38056-38057 |
-RRB- |
denotes |
] |
T8910 |
38057-38059 |
, |
denotes |
, |
T8911 |
38059-38062 |
CC |
denotes |
and |
T8912 |
38063-38067 |
DT |
denotes |
this |
T8913 |
38068-38073 |
NN |
denotes |
study |
T8914 |
38073-38074 |
-RRB- |
denotes |
) |
T8915 |
38075-38077 |
CC |
denotes |
or |
T8916 |
38078-38084 |
JJ |
denotes |
global |
T8917 |
38085-38086 |
-LRB- |
denotes |
[ |
T8918 |
38089-38091 |
CD |
denotes |
60 |
T8919 |
38086-38088 |
CD |
denotes |
53 |
T8920 |
38088-38089 |
, |
denotes |
, |
T8921 |
38091-38092 |
-RRB- |
denotes |
] |
T8922 |
38092-38093 |
. |
denotes |
. |
T8923 |
38093-38428 |
sentence |
denotes |
A detailed analysis of the sampling pattern [3], and in particular the analysis of discrimination tasks that involved “simple” dissimilar monomolecular odor pairs and “difficult” binary mixtures, were necessary to fully capture the characteristics of the olfactory discrimination phenotype for forebrain-specific GluR-B-depleted mice. |
T8924 |
38094-38095 |
DT |
denotes |
A |
T8925 |
38105-38113 |
NN |
denotes |
analysis |
T8926 |
38096-38104 |
JJ |
denotes |
detailed |
T8927 |
38290-38294 |
VBD |
denotes |
were |
T8928 |
38114-38116 |
IN |
denotes |
of |
T8929 |
38117-38120 |
DT |
denotes |
the |
T8930 |
38130-38137 |
NN |
denotes |
pattern |
T8931 |
38121-38129 |
NN |
denotes |
sampling |
T8932 |
38138-38139 |
-LRB- |
denotes |
[ |
T8933 |
38139-38140 |
CD |
denotes |
3 |
T8934 |
38140-38141 |
-RRB- |
denotes |
] |
T8935 |
38141-38143 |
, |
denotes |
, |
T8936 |
38143-38146 |
CC |
denotes |
and |
T8937 |
38147-38149 |
IN |
denotes |
in |
T8938 |
38165-38173 |
NN |
denotes |
analysis |
T8939 |
38150-38160 |
JJ |
denotes |
particular |
T8940 |
38161-38164 |
DT |
denotes |
the |
T8941 |
38174-38176 |
IN |
denotes |
of |
T8942 |
38177-38191 |
NN |
denotes |
discrimination |
T8943 |
38192-38197 |
NNS |
denotes |
tasks |
T8944 |
38198-38202 |
WDT |
denotes |
that |
T8945 |
38203-38211 |
VBD |
denotes |
involved |
T8946 |
38212-38213 |
`` |
denotes |
“ |
T8947 |
38213-38219 |
JJ |
denotes |
simple |
T8948 |
38251-38256 |
NNS |
denotes |
pairs |
T8949 |
38219-38220 |
'' |
denotes |
” |
T8950 |
38221-38231 |
JJ |
denotes |
dissimilar |
T8951 |
38232-38245 |
JJ |
denotes |
monomolecular |
T8952 |
38246-38250 |
NN |
denotes |
odor |
T8953 |
38257-38260 |
CC |
denotes |
and |
T8954 |
38261-38262 |
`` |
denotes |
“ |
T8955 |
38280-38288 |
NNS |
denotes |
mixtures |
T8956 |
38262-38271 |
JJ |
denotes |
difficult |
T8957 |
38271-38272 |
'' |
denotes |
” |
T8958 |
38273-38279 |
JJ |
denotes |
binary |
T8959 |
38288-38290 |
, |
denotes |
, |
T8960 |
38295-38304 |
JJ |
denotes |
necessary |
T8961 |
38305-38307 |
TO |
denotes |
to |
T8962 |
38314-38321 |
VB |
denotes |
capture |
T8963 |
38308-38313 |
RB |
denotes |
fully |
T8964 |
38322-38325 |
DT |
denotes |
the |
T8965 |
38326-38341 |
NNS |
denotes |
characteristics |
T8966 |
38342-38344 |
IN |
denotes |
of |
T8967 |
38345-38348 |
DT |
denotes |
the |
T8968 |
38374-38383 |
NN |
denotes |
phenotype |
T8969 |
38349-38358 |
JJ |
denotes |
olfactory |
T8970 |
38359-38373 |
NN |
denotes |
discrimination |
T8971 |
38384-38387 |
IN |
denotes |
for |
T8972 |
38388-38397 |
NN |
denotes |
forebrain |
T8973 |
38398-38406 |
JJ |
denotes |
specific |
T8974 |
38397-38398 |
HYPH |
denotes |
- |
T8975 |
38423-38427 |
NNS |
denotes |
mice |
T8976 |
38407-38411 |
NN |
denotes |
GluR |
T8977 |
38412-38413 |
NN |
denotes |
B |
T8978 |
38411-38412 |
HYPH |
denotes |
- |
T8979 |
38414-38422 |
VBN |
denotes |
depleted |
T8980 |
38413-38414 |
HYPH |
denotes |
- |
T8981 |
38427-38428 |
. |
denotes |
. |
T8982 |
38428-38629 |
sentence |
denotes |
For closely related binary mixtures, discrimination improvements were largest, consistent with a specific alteration in odor discrimination, rather than a general enhancement of learning capabilities. |
T8983 |
38429-38432 |
IN |
denotes |
For |
T8984 |
38494-38498 |
VBD |
denotes |
were |
T8985 |
38433-38440 |
RB |
denotes |
closely |
T8986 |
38441-38448 |
JJ |
denotes |
related |
T8987 |
38456-38464 |
NNS |
denotes |
mixtures |
T8988 |
38449-38455 |
JJ |
denotes |
binary |
T8989 |
38464-38466 |
, |
denotes |
, |
T8990 |
38466-38480 |
NN |
denotes |
discrimination |
T8991 |
38481-38493 |
NNS |
denotes |
improvements |
T8992 |
38499-38506 |
JJS |
denotes |
largest |
T8993 |
38506-38508 |
, |
denotes |
, |
T8994 |
38508-38518 |
JJ |
denotes |
consistent |
T8995 |
38519-38523 |
IN |
denotes |
with |
T8996 |
38524-38525 |
DT |
denotes |
a |
T8997 |
38535-38545 |
NN |
denotes |
alteration |
T8998 |
38526-38534 |
JJ |
denotes |
specific |
T8999 |
38546-38548 |
IN |
denotes |
in |
T9000 |
38549-38553 |
NN |
denotes |
odor |
T9001 |
38554-38568 |
NN |
denotes |
discrimination |
T9002 |
38568-38570 |
, |
denotes |
, |
T9003 |
38570-38576 |
RB |
denotes |
rather |
T9004 |
38577-38581 |
IN |
denotes |
than |
T9005 |
38582-38583 |
DT |
denotes |
a |
T9006 |
38592-38603 |
NN |
denotes |
enhancement |
T9007 |
38584-38591 |
JJ |
denotes |
general |
T9008 |
38604-38606 |
IN |
denotes |
of |
T9009 |
38607-38615 |
NN |
denotes |
learning |
T9010 |
38616-38628 |
NNS |
denotes |
capabilities |
T9011 |
38628-38629 |
. |
denotes |
. |
T9012 |
38629-38871 |
sentence |
denotes |
This is further supported by the notion that no general improvement was observed in other nonolfactory behavioral tasks, e.g., hippocampus-dependent spatial learning tasks such as matching-to-place spatial reference memory tasks (Figure S2). |
T9013 |
38630-38634 |
DT |
denotes |
This |
T9014 |
38646-38655 |
VBN |
denotes |
supported |
T9015 |
38635-38637 |
VBZ |
denotes |
is |
T9016 |
38638-38645 |
RB |
denotes |
further |
T9017 |
38656-38658 |
IN |
denotes |
by |
T9018 |
38659-38662 |
DT |
denotes |
the |
T9019 |
38663-38669 |
NN |
denotes |
notion |
T9020 |
38670-38674 |
IN |
denotes |
that |
T9021 |
38702-38710 |
VBN |
denotes |
observed |
T9022 |
38675-38677 |
DT |
denotes |
no |
T9023 |
38686-38697 |
NN |
denotes |
improvement |
T9024 |
38678-38685 |
JJ |
denotes |
general |
T9025 |
38698-38701 |
VBD |
denotes |
was |
T9026 |
38711-38713 |
IN |
denotes |
in |
T9027 |
38714-38719 |
JJ |
denotes |
other |
T9028 |
38744-38749 |
NNS |
denotes |
tasks |
T9029 |
38720-38732 |
JJ |
denotes |
nonolfactory |
T9030 |
38733-38743 |
JJ |
denotes |
behavioral |
T9031 |
38749-38751 |
, |
denotes |
, |
T9032 |
38751-38755 |
FW |
denotes |
e.g. |
T9033 |
38796-38801 |
NNS |
denotes |
tasks |
T9034 |
38755-38757 |
, |
denotes |
, |
T9035 |
38757-38768 |
NN |
denotes |
hippocampus |
T9036 |
38769-38778 |
JJ |
denotes |
dependent |
T9037 |
38768-38769 |
HYPH |
denotes |
- |
T9038 |
38779-38786 |
JJ |
denotes |
spatial |
T9039 |
38787-38795 |
NN |
denotes |
learning |
T9040 |
38802-38806 |
JJ |
denotes |
such |
T9041 |
38807-38809 |
IN |
denotes |
as |
T9042 |
38810-38818 |
NN |
denotes |
matching |
T9043 |
38853-38858 |
NNS |
denotes |
tasks |
T9044 |
38818-38819 |
HYPH |
denotes |
- |
T9045 |
38819-38821 |
IN |
denotes |
to |
T9046 |
38821-38822 |
HYPH |
denotes |
- |
T9047 |
38822-38827 |
NN |
denotes |
place |
T9048 |
38828-38835 |
JJ |
denotes |
spatial |
T9049 |
38836-38845 |
NN |
denotes |
reference |
T9050 |
38846-38852 |
NN |
denotes |
memory |
T9051 |
38859-38860 |
-LRB- |
denotes |
( |
T9052 |
38867-38869 |
NN |
denotes |
S2 |
T9053 |
38860-38866 |
NN |
denotes |
Figure |
T9054 |
38869-38870 |
-RRB- |
denotes |
) |
T9055 |
38870-38871 |
. |
denotes |
. |
T9056 |
38871-39090 |
sentence |
denotes |
As no Cre expression and activity was observed in the main olfactory sensory neurons at any developmental stage (Figure S4 and unpublished data), olfactory epithelial function was unaltered by the genetic modification. |
T9057 |
38872-38874 |
IN |
denotes |
As |
T9058 |
38910-38918 |
VBN |
denotes |
observed |
T9059 |
38875-38877 |
DT |
denotes |
no |
T9060 |
38882-38892 |
NN |
denotes |
expression |
T9061 |
38878-38881 |
NN |
denotes |
Cre |
T9062 |
38893-38896 |
CC |
denotes |
and |
T9063 |
38897-38905 |
NN |
denotes |
activity |
T9064 |
38906-38909 |
VBD |
denotes |
was |
T9065 |
39048-39051 |
VBD |
denotes |
was |
T9066 |
38919-38921 |
IN |
denotes |
in |
T9067 |
38922-38925 |
DT |
denotes |
the |
T9068 |
38949-38956 |
NNS |
denotes |
neurons |
T9069 |
38926-38930 |
JJ |
denotes |
main |
T9070 |
38931-38940 |
JJ |
denotes |
olfactory |
T9071 |
38941-38948 |
JJ |
denotes |
sensory |
T9072 |
38957-38959 |
IN |
denotes |
at |
T9073 |
38960-38963 |
DT |
denotes |
any |
T9074 |
38978-38983 |
NN |
denotes |
stage |
T9075 |
38964-38977 |
JJ |
denotes |
developmental |
T9076 |
38984-38985 |
-LRB- |
denotes |
( |
T9077 |
38992-38994 |
NN |
denotes |
S4 |
T9078 |
38985-38991 |
NN |
denotes |
Figure |
T9079 |
38995-38998 |
CC |
denotes |
and |
T9080 |
38999-39010 |
JJ |
denotes |
unpublished |
T9081 |
39011-39015 |
NNS |
denotes |
data |
T9082 |
39015-39016 |
-RRB- |
denotes |
) |
T9083 |
39016-39018 |
, |
denotes |
, |
T9084 |
39018-39027 |
JJ |
denotes |
olfactory |
T9085 |
39039-39047 |
NN |
denotes |
function |
T9086 |
39028-39038 |
JJ |
denotes |
epithelial |
T9087 |
39052-39061 |
JJ |
denotes |
unaltered |
T9088 |
39062-39064 |
IN |
denotes |
by |
T9089 |
39065-39068 |
DT |
denotes |
the |
T9090 |
39077-39089 |
NN |
denotes |
modification |
T9091 |
39069-39076 |
JJ |
denotes |
genetic |
T9092 |
39089-39090 |
. |
denotes |
. |
T9093 |
39090-39289 |
sentence |
denotes |
The vomeronasal organ showed very weak Cre expression (unpublished data), but a role of this structure concerning performance in the olfactory discrimination task is unlikely (for review, see [63]). |
T9094 |
39091-39094 |
DT |
denotes |
The |
T9095 |
39107-39112 |
NN |
denotes |
organ |
T9096 |
39095-39106 |
JJ |
denotes |
vomeronasal |
T9097 |
39113-39119 |
VBD |
denotes |
showed |
T9098 |
39120-39124 |
RB |
denotes |
very |
T9099 |
39125-39129 |
JJ |
denotes |
weak |
T9100 |
39134-39144 |
NN |
denotes |
expression |
T9101 |
39130-39133 |
NN |
denotes |
Cre |
T9102 |
39145-39146 |
-LRB- |
denotes |
( |
T9103 |
39158-39162 |
NNS |
denotes |
data |
T9104 |
39146-39157 |
JJ |
denotes |
unpublished |
T9105 |
39162-39163 |
-RRB- |
denotes |
) |
T9106 |
39163-39165 |
, |
denotes |
, |
T9107 |
39165-39168 |
CC |
denotes |
but |
T9108 |
39169-39170 |
DT |
denotes |
a |
T9109 |
39171-39175 |
NN |
denotes |
role |
T9110 |
39254-39256 |
VBZ |
denotes |
is |
T9111 |
39176-39178 |
IN |
denotes |
of |
T9112 |
39179-39183 |
DT |
denotes |
this |
T9113 |
39184-39193 |
NN |
denotes |
structure |
T9114 |
39194-39204 |
VBG |
denotes |
concerning |
T9115 |
39205-39216 |
NN |
denotes |
performance |
T9116 |
39217-39219 |
IN |
denotes |
in |
T9117 |
39220-39223 |
DT |
denotes |
the |
T9118 |
39249-39253 |
NN |
denotes |
task |
T9119 |
39224-39233 |
JJ |
denotes |
olfactory |
T9120 |
39234-39248 |
NN |
denotes |
discrimination |
T9121 |
39257-39265 |
JJ |
denotes |
unlikely |
T9122 |
39266-39267 |
-LRB- |
denotes |
( |
T9123 |
39279-39282 |
VB |
denotes |
see |
T9124 |
39267-39270 |
IN |
denotes |
for |
T9125 |
39271-39277 |
NN |
denotes |
review |
T9126 |
39277-39279 |
, |
denotes |
, |
T9127 |
39283-39284 |
-LRB- |
denotes |
[ |
T9128 |
39284-39286 |
CD |
denotes |
63 |
T9129 |
39286-39287 |
-RRB- |
denotes |
] |
T9130 |
39287-39288 |
-RRB- |
denotes |
) |
T9131 |
39288-39289 |
. |
denotes |
. |
T9132 |
39289-39427 |
sentence |
denotes |
The behavioral phenotype is thus likely to be associated with the processing of olfactory information rather than the detection of odors. |
T9133 |
39290-39293 |
DT |
denotes |
The |
T9134 |
39305-39314 |
NN |
denotes |
phenotype |
T9135 |
39294-39304 |
JJ |
denotes |
behavioral |
T9136 |
39315-39317 |
VBZ |
denotes |
is |
T9137 |
39318-39322 |
RB |
denotes |
thus |
T9138 |
39323-39329 |
JJ |
denotes |
likely |
T9139 |
39330-39332 |
TO |
denotes |
to |
T9140 |
39336-39346 |
VBN |
denotes |
associated |
T9141 |
39333-39335 |
VB |
denotes |
be |
T9142 |
39347-39351 |
IN |
denotes |
with |
T9143 |
39352-39355 |
DT |
denotes |
the |
T9144 |
39356-39366 |
NN |
denotes |
processing |
T9145 |
39367-39369 |
IN |
denotes |
of |
T9146 |
39370-39379 |
JJ |
denotes |
olfactory |
T9147 |
39380-39391 |
NN |
denotes |
information |
T9148 |
39392-39398 |
RB |
denotes |
rather |
T9149 |
39399-39403 |
IN |
denotes |
than |
T9150 |
39404-39407 |
DT |
denotes |
the |
T9151 |
39408-39417 |
NN |
denotes |
detection |
T9152 |
39418-39420 |
IN |
denotes |
of |
T9153 |
39421-39426 |
NNS |
denotes |
odors |
T9154 |
39426-39427 |
. |
denotes |
. |
T9155 |
39427-39686 |
sentence |
denotes |
Furthermore, increased performance even after long stretches of training and, in particular, increased sampling pattern differences (TB and ATS, unpublished data) supported the notion that GluR-B depletion resulted in enhanced odor discrimination capability. |
T9156 |
39428-39439 |
RB |
denotes |
Furthermore |
T9157 |
39591-39600 |
VBD |
denotes |
supported |
T9158 |
39439-39441 |
, |
denotes |
, |
T9159 |
39441-39450 |
VBN |
denotes |
increased |
T9160 |
39451-39462 |
NN |
denotes |
performance |
T9161 |
39463-39467 |
RB |
denotes |
even |
T9162 |
39468-39473 |
IN |
denotes |
after |
T9163 |
39474-39478 |
JJ |
denotes |
long |
T9164 |
39479-39488 |
NNS |
denotes |
stretches |
T9165 |
39489-39491 |
IN |
denotes |
of |
T9166 |
39492-39500 |
NN |
denotes |
training |
T9167 |
39501-39504 |
CC |
denotes |
and |
T9168 |
39504-39506 |
, |
denotes |
, |
T9169 |
39506-39508 |
IN |
denotes |
in |
T9170 |
39548-39559 |
NNS |
denotes |
differences |
T9171 |
39509-39519 |
JJ |
denotes |
particular |
T9172 |
39519-39521 |
, |
denotes |
, |
T9173 |
39521-39530 |
VBN |
denotes |
increased |
T9174 |
39531-39539 |
NN |
denotes |
sampling |
T9175 |
39540-39547 |
NN |
denotes |
pattern |
T9176 |
39560-39561 |
-LRB- |
denotes |
( |
T9177 |
39585-39589 |
NNS |
denotes |
data |
T9178 |
39561-39563 |
NN |
denotes |
TB |
T9179 |
39564-39567 |
CC |
denotes |
and |
T9180 |
39568-39571 |
NN |
denotes |
ATS |
T9181 |
39571-39573 |
, |
denotes |
, |
T9182 |
39573-39584 |
JJ |
denotes |
unpublished |
T9183 |
39589-39590 |
-RRB- |
denotes |
) |
T9184 |
39601-39604 |
DT |
denotes |
the |
T9185 |
39605-39611 |
NN |
denotes |
notion |
T9186 |
39612-39616 |
IN |
denotes |
that |
T9187 |
39634-39642 |
VBD |
denotes |
resulted |
T9188 |
39617-39621 |
NN |
denotes |
GluR |
T9189 |
39622-39623 |
NN |
denotes |
B |
T9190 |
39621-39622 |
HYPH |
denotes |
- |
T9191 |
39624-39633 |
NN |
denotes |
depletion |
T9192 |
39643-39645 |
IN |
denotes |
in |
T9193 |
39646-39654 |
VBN |
denotes |
enhanced |
T9194 |
39675-39685 |
NN |
denotes |
capability |
T9195 |
39655-39659 |
NN |
denotes |
odor |
T9196 |
39660-39674 |
NN |
denotes |
discrimination |
T9197 |
39685-39686 |
. |
denotes |
. |
T9198 |
39686-39846 |
sentence |
denotes |
The learning phenotype might thus be a result of this enhanced discrimination capability or reflect additional changes in circuits underlying task acquisition. |
T9199 |
39687-39690 |
DT |
denotes |
The |
T9200 |
39700-39709 |
NN |
denotes |
phenotype |
T9201 |
39691-39699 |
NN |
denotes |
learning |
T9202 |
39721-39723 |
VB |
denotes |
be |
T9203 |
39710-39715 |
MD |
denotes |
might |
T9204 |
39716-39720 |
RB |
denotes |
thus |
T9205 |
39724-39725 |
DT |
denotes |
a |
T9206 |
39726-39732 |
NN |
denotes |
result |
T9207 |
39733-39735 |
IN |
denotes |
of |
T9208 |
39736-39740 |
DT |
denotes |
this |
T9209 |
39765-39775 |
NN |
denotes |
capability |
T9210 |
39741-39749 |
VBN |
denotes |
enhanced |
T9211 |
39750-39764 |
NN |
denotes |
discrimination |
T9212 |
39776-39778 |
CC |
denotes |
or |
T9213 |
39779-39786 |
VB |
denotes |
reflect |
T9214 |
39787-39797 |
JJ |
denotes |
additional |
T9215 |
39798-39805 |
NNS |
denotes |
changes |
T9216 |
39806-39808 |
IN |
denotes |
in |
T9217 |
39809-39817 |
NNS |
denotes |
circuits |
T9218 |
39818-39828 |
VBG |
denotes |
underlying |
T9219 |
39829-39833 |
NN |
denotes |
task |
T9220 |
39834-39845 |
NN |
denotes |
acquisition |
T9221 |
39845-39846 |
. |
denotes |
. |
T9487 |
39848-39856 |
JJ |
denotes |
Putative |
T9488 |
39866-39871 |
NN |
denotes |
Basis |
T9489 |
39857-39865 |
JJ |
denotes |
Cellular |
T9490 |
39872-39874 |
IN |
denotes |
of |
T9491 |
39875-39883 |
VBN |
denotes |
Enhanced |
T9492 |
39889-39903 |
NN |
denotes |
Discrimination |
T9493 |
39884-39888 |
NN |
denotes |
Odor |
T9494 |
39904-39907 |
CC |
denotes |
and |
T9495 |
39908-39916 |
NN |
denotes |
Learning |
T9496 |
39916-40133 |
sentence |
denotes |
AMPAR properties were altered specifically in neurons of forebrain areas, most notably olfactory bulb, olfactory cortex, and other cortical areas and hippocampus, leading to enhanced odor discrimination and learning. |
T9497 |
39917-39922 |
NN |
denotes |
AMPAR |
T9498 |
39923-39933 |
NNS |
denotes |
properties |
T9499 |
39939-39946 |
VBN |
denotes |
altered |
T9500 |
39934-39938 |
VBD |
denotes |
were |
T9501 |
39947-39959 |
RB |
denotes |
specifically |
T9502 |
39960-39962 |
IN |
denotes |
in |
T9503 |
39963-39970 |
NNS |
denotes |
neurons |
T9504 |
39971-39973 |
IN |
denotes |
of |
T9505 |
39974-39983 |
NN |
denotes |
forebrain |
T9506 |
39984-39989 |
NNS |
denotes |
areas |
T9507 |
39989-39991 |
, |
denotes |
, |
T9508 |
39991-39995 |
RBS |
denotes |
most |
T9509 |
39996-40003 |
RB |
denotes |
notably |
T9510 |
40014-40018 |
NN |
denotes |
bulb |
T9511 |
40004-40013 |
JJ |
denotes |
olfactory |
T9512 |
40018-40020 |
, |
denotes |
, |
T9513 |
40020-40029 |
JJ |
denotes |
olfactory |
T9514 |
40030-40036 |
NN |
denotes |
cortex |
T9515 |
40036-40038 |
, |
denotes |
, |
T9516 |
40038-40041 |
CC |
denotes |
and |
T9517 |
40042-40047 |
JJ |
denotes |
other |
T9518 |
40057-40062 |
NNS |
denotes |
areas |
T9519 |
40048-40056 |
JJ |
denotes |
cortical |
T9520 |
40063-40066 |
CC |
denotes |
and |
T9521 |
40067-40078 |
NN |
denotes |
hippocampus |
T9522 |
40078-40080 |
, |
denotes |
, |
T9523 |
40080-40087 |
VBG |
denotes |
leading |
T9524 |
40088-40090 |
IN |
denotes |
to |
T9525 |
40091-40099 |
VBN |
denotes |
enhanced |
T9526 |
40105-40119 |
NN |
denotes |
discrimination |
T9527 |
40100-40104 |
NN |
denotes |
odor |
T9528 |
40120-40123 |
CC |
denotes |
and |
T9529 |
40124-40132 |
NN |
denotes |
learning |
T9530 |
40132-40133 |
. |
denotes |
. |
T9531 |
40133-40387 |
sentence |
denotes |
Interestingly, transgenic expression of GFPGluR-B in GluR-BΔFB mice (genetic “rescue”), specifically in piriform cortex and hippocampus with no detectable expression in the olfactory bulb, did not alter enhanced discrimination and learning capabilities. |
T9532 |
40134-40147 |
RB |
denotes |
Interestingly |
T9533 |
40331-40336 |
VB |
denotes |
alter |
T9534 |
40147-40149 |
, |
denotes |
, |
T9535 |
40149-40159 |
JJ |
denotes |
transgenic |
T9536 |
40160-40170 |
NN |
denotes |
expression |
T9537 |
40171-40173 |
IN |
denotes |
of |
T9538 |
40174-40181 |
NN |
denotes |
GFPGluR |
T9539 |
40182-40183 |
NN |
denotes |
B |
T9540 |
40181-40182 |
HYPH |
denotes |
- |
T9541 |
40184-40186 |
IN |
denotes |
in |
T9542 |
40187-40191 |
NN |
denotes |
GluR |
T9543 |
40192-40196 |
NN |
denotes |
BΔFB |
T9544 |
40191-40192 |
HYPH |
denotes |
- |
T9545 |
40197-40201 |
NNS |
denotes |
mice |
T9546 |
40202-40203 |
-LRB- |
denotes |
( |
T9547 |
40212-40218 |
NN |
denotes |
rescue |
T9548 |
40203-40210 |
JJ |
denotes |
genetic |
T9549 |
40211-40212 |
`` |
denotes |
“ |
T9550 |
40218-40219 |
'' |
denotes |
” |
T9551 |
40219-40220 |
-RRB- |
denotes |
) |
T9552 |
40220-40222 |
, |
denotes |
, |
T9553 |
40222-40234 |
RB |
denotes |
specifically |
T9554 |
40235-40237 |
IN |
denotes |
in |
T9555 |
40238-40246 |
JJ |
denotes |
piriform |
T9556 |
40247-40253 |
NN |
denotes |
cortex |
T9557 |
40254-40257 |
CC |
denotes |
and |
T9558 |
40258-40269 |
NN |
denotes |
hippocampus |
T9559 |
40270-40274 |
IN |
denotes |
with |
T9560 |
40275-40277 |
DT |
denotes |
no |
T9561 |
40289-40299 |
NN |
denotes |
expression |
T9562 |
40278-40288 |
JJ |
denotes |
detectable |
T9563 |
40300-40302 |
IN |
denotes |
in |
T9564 |
40303-40306 |
DT |
denotes |
the |
T9565 |
40317-40321 |
NN |
denotes |
bulb |
T9566 |
40307-40316 |
JJ |
denotes |
olfactory |
T9567 |
40321-40323 |
, |
denotes |
, |
T9568 |
40323-40326 |
VBD |
denotes |
did |
T9569 |
40327-40330 |
RB |
denotes |
not |
T9570 |
40337-40345 |
VBN |
denotes |
enhanced |
T9571 |
40374-40386 |
NNS |
denotes |
capabilities |
T9572 |
40346-40360 |
NN |
denotes |
discrimination |
T9573 |
40361-40364 |
CC |
denotes |
and |
T9574 |
40365-40373 |
NN |
denotes |
learning |
T9575 |
40386-40387 |
. |
denotes |
. |
T9576 |
40387-40490 |
sentence |
denotes |
This is consistent with a primary role of the olfactory bulb in olfactory discrimination and learning. |
T9577 |
40388-40392 |
DT |
denotes |
This |
T9578 |
40393-40395 |
VBZ |
denotes |
is |
T9579 |
40396-40406 |
JJ |
denotes |
consistent |
T9580 |
40407-40411 |
IN |
denotes |
with |
T9581 |
40412-40413 |
DT |
denotes |
a |
T9582 |
40422-40426 |
NN |
denotes |
role |
T9583 |
40414-40421 |
JJ |
denotes |
primary |
T9584 |
40427-40429 |
IN |
denotes |
of |
T9585 |
40430-40433 |
DT |
denotes |
the |
T9586 |
40444-40448 |
NN |
denotes |
bulb |
T9587 |
40434-40443 |
JJ |
denotes |
olfactory |
T9588 |
40449-40451 |
IN |
denotes |
in |
T9589 |
40452-40461 |
JJ |
denotes |
olfactory |
T9590 |
40462-40476 |
NN |
denotes |
discrimination |
T9591 |
40477-40480 |
CC |
denotes |
and |
T9592 |
40481-40489 |
NN |
denotes |
learning |
T9593 |
40489-40490 |
. |
denotes |
. |
T9594 |
40490-40644 |
sentence |
denotes |
Alternatively, transgenic protein levels might have been too low to alter discrimination and learning capabilities, although memory was clearly affected. |
T9595 |
40491-40504 |
RB |
denotes |
Alternatively |
T9596 |
40543-40547 |
VBN |
denotes |
been |
T9597 |
40504-40506 |
, |
denotes |
, |
T9598 |
40506-40516 |
JJ |
denotes |
transgenic |
T9599 |
40525-40531 |
NNS |
denotes |
levels |
T9600 |
40517-40524 |
NN |
denotes |
protein |
T9601 |
40532-40537 |
MD |
denotes |
might |
T9602 |
40538-40542 |
VB |
denotes |
have |
T9603 |
40548-40551 |
RB |
denotes |
too |
T9604 |
40552-40555 |
JJ |
denotes |
low |
T9605 |
40556-40558 |
TO |
denotes |
to |
T9606 |
40559-40564 |
VB |
denotes |
alter |
T9607 |
40565-40579 |
NN |
denotes |
discrimination |
T9608 |
40593-40605 |
NNS |
denotes |
capabilities |
T9609 |
40580-40583 |
CC |
denotes |
and |
T9610 |
40584-40592 |
NN |
denotes |
learning |
T9611 |
40605-40607 |
, |
denotes |
, |
T9612 |
40607-40615 |
IN |
denotes |
although |
T9613 |
40635-40643 |
VBN |
denotes |
affected |
T9614 |
40616-40622 |
NN |
denotes |
memory |
T9615 |
40623-40626 |
VBD |
denotes |
was |
T9616 |
40627-40634 |
RB |
denotes |
clearly |
T9617 |
40643-40644 |
. |
denotes |
. |
T9618 |
40644-40734 |
sentence |
denotes |
This notion will be further tested in mice with piriform cortex-specific GluR-B ablation. |
T9619 |
40645-40649 |
DT |
denotes |
This |
T9620 |
40650-40656 |
NN |
denotes |
notion |
T9621 |
40673-40679 |
VBN |
denotes |
tested |
T9622 |
40657-40661 |
MD |
denotes |
will |
T9623 |
40662-40664 |
VB |
denotes |
be |
T9624 |
40665-40672 |
RB |
denotes |
further |
T9625 |
40680-40682 |
IN |
denotes |
in |
T9626 |
40683-40687 |
NNS |
denotes |
mice |
T9627 |
40688-40692 |
IN |
denotes |
with |
T9628 |
40693-40701 |
JJ |
denotes |
piriform |
T9629 |
40702-40708 |
NN |
denotes |
cortex |
T9630 |
40709-40717 |
JJ |
denotes |
specific |
T9631 |
40708-40709 |
HYPH |
denotes |
- |
T9632 |
40725-40733 |
NN |
denotes |
ablation |
T9633 |
40718-40722 |
NN |
denotes |
GluR |
T9634 |
40723-40724 |
NN |
denotes |
B |
T9635 |
40722-40723 |
HYPH |
denotes |
- |
T9636 |
40733-40734 |
. |
denotes |
. |
T9637 |
40734-41003 |
sentence |
denotes |
A direct contribution to the phenotype by Ca2+ influx through genetically modified AMPA channels seems to be likely, since mice expressing Q/R site-unedited GluR-B showed even better odor learning and discrimination performance compared with mice with depleted GluR-B. |
T9638 |
40735-40736 |
DT |
denotes |
A |
T9639 |
40744-40756 |
NN |
denotes |
contribution |
T9640 |
40737-40743 |
JJ |
denotes |
direct |
T9641 |
40832-40837 |
VBZ |
denotes |
seems |
T9642 |
40757-40759 |
IN |
denotes |
to |
T9643 |
40760-40763 |
DT |
denotes |
the |
T9644 |
40764-40773 |
NN |
denotes |
phenotype |
T9645 |
40774-40776 |
IN |
denotes |
by |
T9646 |
40777-40780 |
NN |
denotes |
Ca2 |
T9647 |
40782-40788 |
NN |
denotes |
influx |
T9648 |
40780-40781 |
SYM |
denotes |
+ |
T9649 |
40789-40796 |
IN |
denotes |
through |
T9650 |
40797-40808 |
RB |
denotes |
genetically |
T9651 |
40809-40817 |
VBN |
denotes |
modified |
T9652 |
40823-40831 |
NNS |
denotes |
channels |
T9653 |
40818-40822 |
NN |
denotes |
AMPA |
T9654 |
40838-40840 |
TO |
denotes |
to |
T9655 |
40841-40843 |
VB |
denotes |
be |
T9656 |
40844-40850 |
JJ |
denotes |
likely |
T9657 |
40850-40852 |
, |
denotes |
, |
T9658 |
40852-40857 |
IN |
denotes |
since |
T9659 |
40899-40905 |
VBD |
denotes |
showed |
T9660 |
40858-40862 |
NNS |
denotes |
mice |
T9661 |
40863-40873 |
VBG |
denotes |
expressing |
T9662 |
40874-40875 |
NN |
denotes |
Q |
T9663 |
40876-40877 |
NN |
denotes |
R |
T9664 |
40875-40876 |
HYPH |
denotes |
/ |
T9665 |
40897-40898 |
NN |
denotes |
B |
T9666 |
40878-40882 |
NN |
denotes |
site |
T9667 |
40883-40891 |
JJ |
denotes |
unedited |
T9668 |
40882-40883 |
HYPH |
denotes |
- |
T9669 |
40892-40896 |
NN |
denotes |
GluR |
T9670 |
40896-40897 |
HYPH |
denotes |
- |
T9671 |
40906-40910 |
RB |
denotes |
even |
T9672 |
40911-40917 |
JJR |
denotes |
better |
T9673 |
40951-40962 |
NN |
denotes |
performance |
T9674 |
40918-40922 |
NN |
denotes |
odor |
T9675 |
40923-40931 |
NN |
denotes |
learning |
T9676 |
40932-40935 |
CC |
denotes |
and |
T9677 |
40936-40950 |
NN |
denotes |
discrimination |
T9678 |
40963-40971 |
VBN |
denotes |
compared |
T9679 |
40972-40976 |
IN |
denotes |
with |
T9680 |
40977-40981 |
NNS |
denotes |
mice |
T9681 |
40982-40986 |
IN |
denotes |
with |
T9682 |
40987-40995 |
VBN |
denotes |
depleted |
T9683 |
41001-41002 |
NN |
denotes |
B |
T9684 |
40996-41000 |
NN |
denotes |
GluR |
T9685 |
41000-41001 |
HYPH |
denotes |
- |
T9686 |
41002-41003 |
. |
denotes |
. |
T9687 |
41003-41136 |
sentence |
denotes |
In both mouse models Ca2+ influx through AMPA channels is increased, whereas the effect on the macroscopic AMPA conductance differs. |
T9688 |
41004-41006 |
IN |
denotes |
In |
T9689 |
41062-41071 |
VBN |
denotes |
increased |
T9690 |
41007-41011 |
DT |
denotes |
both |
T9691 |
41018-41024 |
NNS |
denotes |
models |
T9692 |
41012-41017 |
NN |
denotes |
mouse |
T9693 |
41025-41028 |
NN |
denotes |
Ca2 |
T9694 |
41030-41036 |
NN |
denotes |
influx |
T9695 |
41028-41029 |
SYM |
denotes |
+ |
T9696 |
41037-41044 |
IN |
denotes |
through |
T9697 |
41045-41049 |
NN |
denotes |
AMPA |
T9698 |
41050-41058 |
NNS |
denotes |
channels |
T9699 |
41059-41061 |
VBZ |
denotes |
is |
T9700 |
41071-41073 |
, |
denotes |
, |
T9701 |
41073-41080 |
IN |
denotes |
whereas |
T9702 |
41128-41135 |
VBZ |
denotes |
differs |
T9703 |
41081-41084 |
DT |
denotes |
the |
T9704 |
41085-41091 |
NN |
denotes |
effect |
T9705 |
41092-41094 |
IN |
denotes |
on |
T9706 |
41095-41098 |
DT |
denotes |
the |
T9707 |
41116-41127 |
NN |
denotes |
conductance |
T9708 |
41099-41110 |
JJ |
denotes |
macroscopic |
T9709 |
41111-41115 |
NN |
denotes |
AMPA |
T9710 |
41135-41136 |
. |
denotes |
. |
T9711 |
41136-41290 |
sentence |
denotes |
AMPAR currents are reduced in mice not expressing GluR-B [51], possibly due to fewer synaptic AMPA channels and impaired AMPAR trafficking and recycling. |
T9712 |
41137-41142 |
NN |
denotes |
AMPAR |
T9713 |
41143-41151 |
NNS |
denotes |
currents |
T9714 |
41156-41163 |
VBN |
denotes |
reduced |
T9715 |
41152-41155 |
VBP |
denotes |
are |
T9716 |
41164-41166 |
IN |
denotes |
in |
T9717 |
41167-41171 |
NNS |
denotes |
mice |
T9718 |
41172-41175 |
RB |
denotes |
not |
T9719 |
41176-41186 |
VBG |
denotes |
expressing |
T9720 |
41187-41191 |
NN |
denotes |
GluR |
T9721 |
41192-41193 |
NN |
denotes |
B |
T9722 |
41191-41192 |
HYPH |
denotes |
- |
T9723 |
41194-41195 |
-LRB- |
denotes |
[ |
T9724 |
41195-41197 |
CD |
denotes |
51 |
T9725 |
41197-41198 |
-RRB- |
denotes |
] |
T9726 |
41198-41200 |
, |
denotes |
, |
T9727 |
41200-41208 |
RB |
denotes |
possibly |
T9728 |
41209-41212 |
IN |
denotes |
due |
T9729 |
41213-41215 |
IN |
denotes |
to |
T9730 |
41216-41221 |
JJR |
denotes |
fewer |
T9731 |
41236-41244 |
NNS |
denotes |
channels |
T9732 |
41222-41230 |
JJ |
denotes |
synaptic |
T9733 |
41231-41235 |
NN |
denotes |
AMPA |
T9734 |
41245-41248 |
CC |
denotes |
and |
T9735 |
41249-41257 |
VBN |
denotes |
impaired |
T9736 |
41264-41275 |
NN |
denotes |
trafficking |
T9737 |
41258-41263 |
NN |
denotes |
AMPAR |
T9738 |
41276-41279 |
CC |
denotes |
and |
T9739 |
41280-41289 |
NN |
denotes |
recycling |
T9740 |
41289-41290 |
. |
denotes |
. |
T9741 |
41290-41691 |
sentence |
denotes |
In mice expressing the unedited form of GluR-B(Q), macroscopic conductance in whole-cell patches of CA1 pyramidals is increased [60], but excitatory transmission in CA3-to-CA1 cell synapses is somewhat reduced, in spite of a lower threshold for generating a population spike [58], indicating increased synaptic excitability by sustained GluR-B(Q) expression, in line with the seizure-prone phenotype. |
T9742 |
41291-41293 |
IN |
denotes |
In |
T9743 |
41409-41418 |
VBN |
denotes |
increased |
T9744 |
41294-41298 |
NNS |
denotes |
mice |
T9745 |
41299-41309 |
VBG |
denotes |
expressing |
T9746 |
41310-41313 |
DT |
denotes |
the |
T9747 |
41323-41327 |
NN |
denotes |
form |
T9748 |
41314-41322 |
JJ |
denotes |
unedited |
T9749 |
41328-41330 |
IN |
denotes |
of |
T9750 |
41331-41335 |
NN |
denotes |
GluR |
T9751 |
41338-41339 |
NN |
denotes |
Q |
T9752 |
41335-41336 |
HYPH |
denotes |
- |
T9753 |
41336-41337 |
NN |
denotes |
B |
T9754 |
41337-41338 |
-LRB- |
denotes |
( |
T9755 |
41339-41340 |
-RRB- |
denotes |
) |
T9756 |
41340-41342 |
, |
denotes |
, |
T9757 |
41342-41353 |
JJ |
denotes |
macroscopic |
T9758 |
41354-41365 |
NN |
denotes |
conductance |
T9759 |
41366-41368 |
IN |
denotes |
in |
T9760 |
41369-41374 |
JJ |
denotes |
whole |
T9761 |
41375-41379 |
NN |
denotes |
cell |
T9762 |
41374-41375 |
HYPH |
denotes |
- |
T9763 |
41380-41387 |
NNS |
denotes |
patches |
T9764 |
41388-41390 |
IN |
denotes |
of |
T9765 |
41391-41394 |
NN |
denotes |
CA1 |
T9766 |
41395-41405 |
NNS |
denotes |
pyramidals |
T9767 |
41406-41408 |
VBZ |
denotes |
is |
T9768 |
41419-41420 |
-LRB- |
denotes |
[ |
T9769 |
41420-41422 |
CD |
denotes |
60 |
T9770 |
41422-41423 |
-RRB- |
denotes |
] |
T9771 |
41423-41425 |
, |
denotes |
, |
T9772 |
41425-41428 |
CC |
denotes |
but |
T9773 |
41429-41439 |
JJ |
denotes |
excitatory |
T9774 |
41440-41452 |
NN |
denotes |
transmission |
T9775 |
41481-41483 |
VBZ |
denotes |
is |
T9776 |
41453-41455 |
IN |
denotes |
in |
T9777 |
41456-41459 |
NN |
denotes |
CA3 |
T9778 |
41472-41480 |
NNS |
denotes |
synapses |
T9779 |
41459-41460 |
HYPH |
denotes |
- |
T9780 |
41460-41462 |
IN |
denotes |
to |
T9781 |
41462-41463 |
HYPH |
denotes |
- |
T9782 |
41463-41466 |
NN |
denotes |
CA1 |
T9783 |
41467-41471 |
NN |
denotes |
cell |
T9784 |
41484-41492 |
RB |
denotes |
somewhat |
T9785 |
41493-41500 |
JJ |
denotes |
reduced |
T9786 |
41500-41502 |
, |
denotes |
, |
T9787 |
41502-41504 |
IN |
denotes |
in |
T9788 |
41505-41510 |
NN |
denotes |
spite |
T9789 |
41511-41513 |
IN |
denotes |
of |
T9790 |
41514-41515 |
DT |
denotes |
a |
T9791 |
41522-41531 |
NN |
denotes |
threshold |
T9792 |
41516-41521 |
JJR |
denotes |
lower |
T9793 |
41532-41535 |
IN |
denotes |
for |
T9794 |
41536-41546 |
VBG |
denotes |
generating |
T9795 |
41547-41548 |
DT |
denotes |
a |
T9796 |
41560-41565 |
NN |
denotes |
spike |
T9797 |
41549-41559 |
NN |
denotes |
population |
T9798 |
41566-41567 |
-LRB- |
denotes |
[ |
T9799 |
41567-41569 |
CD |
denotes |
58 |
T9800 |
41569-41570 |
-RRB- |
denotes |
] |
T9801 |
41570-41572 |
, |
denotes |
, |
T9802 |
41572-41582 |
VBG |
denotes |
indicating |
T9803 |
41583-41592 |
VBN |
denotes |
increased |
T9804 |
41602-41614 |
NN |
denotes |
excitability |
T9805 |
41593-41601 |
JJ |
denotes |
synaptic |
T9806 |
41615-41617 |
IN |
denotes |
by |
T9807 |
41618-41627 |
VBN |
denotes |
sustained |
T9808 |
41638-41648 |
NN |
denotes |
expression |
T9809 |
41628-41632 |
NN |
denotes |
GluR |
T9810 |
41635-41636 |
NN |
denotes |
Q |
T9811 |
41632-41633 |
HYPH |
denotes |
- |
T9812 |
41633-41634 |
NN |
denotes |
B |
T9813 |
41634-41635 |
-LRB- |
denotes |
( |
T9814 |
41636-41637 |
-RRB- |
denotes |
) |
T9815 |
41648-41650 |
, |
denotes |
, |
T9816 |
41650-41652 |
IN |
denotes |
in |
T9817 |
41653-41657 |
NN |
denotes |
line |
T9818 |
41658-41662 |
IN |
denotes |
with |
T9819 |
41663-41666 |
DT |
denotes |
the |
T9820 |
41681-41690 |
NN |
denotes |
phenotype |
T9821 |
41667-41674 |
NN |
denotes |
seizure |
T9822 |
41675-41680 |
JJ |
denotes |
prone |
T9823 |
41674-41675 |
HYPH |
denotes |
- |
T9824 |
41690-41691 |
. |
denotes |
. |
T9825 |
41691-41769 |
sentence |
denotes |
Yet, both mouse models yield enhanced discrimination and learning capability. |
T9826 |
41692-41695 |
RB |
denotes |
Yet |
T9827 |
41715-41720 |
VBP |
denotes |
yield |
T9828 |
41695-41697 |
, |
denotes |
, |
T9829 |
41697-41701 |
DT |
denotes |
both |
T9830 |
41708-41714 |
NNS |
denotes |
models |
T9831 |
41702-41707 |
NN |
denotes |
mouse |
T9832 |
41721-41729 |
VBN |
denotes |
enhanced |
T9833 |
41758-41768 |
NN |
denotes |
capability |
T9834 |
41730-41744 |
NN |
denotes |
discrimination |
T9835 |
41745-41748 |
CC |
denotes |
and |
T9836 |
41749-41757 |
NN |
denotes |
learning |
T9837 |
41768-41769 |
. |
denotes |
. |
T9838 |
41769-41937 |
sentence |
denotes |
The milder phenotype upon GluR-B depletion could be attributed to reduced AMPAR densities at synapses [40,41] and therefore probably to a lesser extent of Ca2+ influx. |
T9839 |
41770-41773 |
DT |
denotes |
The |
T9840 |
41781-41790 |
NN |
denotes |
phenotype |
T9841 |
41774-41780 |
JJR |
denotes |
milder |
T9842 |
41822-41832 |
VBN |
denotes |
attributed |
T9843 |
41791-41795 |
IN |
denotes |
upon |
T9844 |
41796-41800 |
NN |
denotes |
GluR |
T9845 |
41801-41802 |
NN |
denotes |
B |
T9846 |
41800-41801 |
HYPH |
denotes |
- |
T9847 |
41803-41812 |
NN |
denotes |
depletion |
T9848 |
41813-41818 |
MD |
denotes |
could |
T9849 |
41819-41821 |
VB |
denotes |
be |
T9850 |
41833-41835 |
IN |
denotes |
to |
T9851 |
41836-41843 |
VBN |
denotes |
reduced |
T9852 |
41850-41859 |
NNS |
denotes |
densities |
T9853 |
41844-41849 |
NN |
denotes |
AMPAR |
T9854 |
41860-41862 |
IN |
denotes |
at |
T9855 |
41863-41871 |
NNS |
denotes |
synapses |
T9856 |
41872-41873 |
-LRB- |
denotes |
[ |
T9857 |
41876-41878 |
CD |
denotes |
41 |
T9858 |
41873-41875 |
CD |
denotes |
40 |
T9859 |
41875-41876 |
, |
denotes |
, |
T9860 |
41878-41879 |
-RRB- |
denotes |
] |
T9861 |
41880-41883 |
CC |
denotes |
and |
T9862 |
41884-41893 |
RB |
denotes |
therefore |
T9863 |
41903-41905 |
IN |
denotes |
to |
T9864 |
41894-41902 |
RB |
denotes |
probably |
T9865 |
41906-41907 |
DT |
denotes |
a |
T9866 |
41915-41921 |
NN |
denotes |
extent |
T9867 |
41908-41914 |
JJR |
denotes |
lesser |
T9868 |
41922-41924 |
IN |
denotes |
of |
T9869 |
41925-41928 |
NN |
denotes |
Ca2 |
T9870 |
41930-41936 |
NN |
denotes |
influx |
T9871 |
41928-41929 |
SYM |
denotes |
+ |
T9872 |
41936-41937 |
. |
denotes |
. |
T9873 |
41937-42212 |
sentence |
denotes |
This is further supported by kainate-induced Co2+ uptake in acute brain slices, revealing considerably higher Co2+ uptake via Ca2+-permeable AMPARs in hippocampal pyramidal neurons of mice expressing GluR-B(Q), than those lacking GluR-B (DRS, RS, and PHS, unpublished data). |
T9874 |
41938-41942 |
DT |
denotes |
This |
T9875 |
41954-41963 |
VBN |
denotes |
supported |
T9876 |
41943-41945 |
VBZ |
denotes |
is |
T9877 |
41946-41953 |
RB |
denotes |
further |
T9878 |
41964-41966 |
IN |
denotes |
by |
T9879 |
41967-41974 |
NN |
denotes |
kainate |
T9880 |
41975-41982 |
VBN |
denotes |
induced |
T9881 |
41974-41975 |
HYPH |
denotes |
- |
T9882 |
41988-41994 |
NN |
denotes |
uptake |
T9883 |
41983-41986 |
NN |
denotes |
Co2 |
T9884 |
41986-41987 |
SYM |
denotes |
+ |
T9885 |
41995-41997 |
IN |
denotes |
in |
T9886 |
41998-42003 |
JJ |
denotes |
acute |
T9887 |
42010-42016 |
NNS |
denotes |
slices |
T9888 |
42004-42009 |
NN |
denotes |
brain |
T9889 |
42016-42018 |
, |
denotes |
, |
T9890 |
42018-42027 |
VBG |
denotes |
revealing |
T9891 |
42028-42040 |
RB |
denotes |
considerably |
T9892 |
42041-42047 |
JJR |
denotes |
higher |
T9893 |
42053-42059 |
NN |
denotes |
uptake |
T9894 |
42048-42051 |
NN |
denotes |
Co2 |
T9895 |
42051-42052 |
SYM |
denotes |
+ |
T9896 |
42060-42063 |
IN |
denotes |
via |
T9897 |
42064-42067 |
NN |
denotes |
Ca2 |
T9898 |
42069-42078 |
JJ |
denotes |
permeable |
T9899 |
42067-42068 |
SYM |
denotes |
+ |
T9900 |
42068-42069 |
HYPH |
denotes |
- |
T9901 |
42079-42085 |
NNS |
denotes |
AMPARs |
T9902 |
42086-42088 |
IN |
denotes |
in |
T9903 |
42089-42100 |
JJ |
denotes |
hippocampal |
T9904 |
42111-42118 |
NNS |
denotes |
neurons |
T9905 |
42101-42110 |
JJ |
denotes |
pyramidal |
T9906 |
42119-42121 |
IN |
denotes |
of |
T9907 |
42122-42126 |
NNS |
denotes |
mice |
T9908 |
42127-42137 |
VBG |
denotes |
expressing |
T9909 |
42138-42142 |
NN |
denotes |
GluR |
T9910 |
42143-42144 |
NN |
denotes |
B |
T9911 |
42142-42143 |
HYPH |
denotes |
- |
T9912 |
42144-42145 |
-LRB- |
denotes |
( |
T9913 |
42145-42146 |
NN |
denotes |
Q |
T9914 |
42146-42147 |
-RRB- |
denotes |
) |
T9915 |
42147-42149 |
, |
denotes |
, |
T9916 |
42149-42153 |
IN |
denotes |
than |
T9917 |
42154-42159 |
DT |
denotes |
those |
T9918 |
42160-42167 |
VBG |
denotes |
lacking |
T9919 |
42168-42172 |
NN |
denotes |
GluR |
T9920 |
42173-42174 |
NN |
denotes |
B |
T9921 |
42172-42173 |
HYPH |
denotes |
- |
T9922 |
42175-42176 |
-LRB- |
denotes |
( |
T9923 |
42206-42210 |
NNS |
denotes |
data |
T9924 |
42176-42179 |
NN |
denotes |
DRS |
T9925 |
42179-42181 |
, |
denotes |
, |
T9926 |
42181-42183 |
NN |
denotes |
RS |
T9927 |
42183-42185 |
, |
denotes |
, |
T9928 |
42185-42188 |
CC |
denotes |
and |
T9929 |
42189-42192 |
NN |
denotes |
PHS |
T9930 |
42192-42194 |
, |
denotes |
, |
T9931 |
42194-42205 |
JJ |
denotes |
unpublished |
T9932 |
42210-42211 |
-RRB- |
denotes |
) |
T9933 |
42211-42212 |
. |
denotes |
. |
T9934 |
42212-42368 |
sentence |
denotes |
Normally, GluR-B-containing AMPARs are prominently localized at the dendrodendritic synapse between mitral and granule cells in the olfactory bulb [64,65]. |
T9935 |
42213-42221 |
RB |
denotes |
Normally |
T9936 |
42264-42273 |
VBN |
denotes |
localized |
T9937 |
42221-42223 |
, |
denotes |
, |
T9938 |
42223-42227 |
NN |
denotes |
GluR |
T9939 |
42228-42229 |
NN |
denotes |
B |
T9940 |
42227-42228 |
HYPH |
denotes |
- |
T9941 |
42230-42240 |
VBG |
denotes |
containing |
T9942 |
42229-42230 |
HYPH |
denotes |
- |
T9943 |
42241-42247 |
NNS |
denotes |
AMPARs |
T9944 |
42248-42251 |
VBP |
denotes |
are |
T9945 |
42252-42263 |
RB |
denotes |
prominently |
T9946 |
42274-42276 |
IN |
denotes |
at |
T9947 |
42277-42280 |
DT |
denotes |
the |
T9948 |
42297-42304 |
NN |
denotes |
synapse |
T9949 |
42281-42296 |
JJ |
denotes |
dendrodendritic |
T9950 |
42305-42312 |
IN |
denotes |
between |
T9951 |
42313-42319 |
JJ |
denotes |
mitral |
T9952 |
42332-42337 |
NNS |
denotes |
cells |
T9953 |
42320-42323 |
CC |
denotes |
and |
T9954 |
42324-42331 |
NN |
denotes |
granule |
T9955 |
42338-42340 |
IN |
denotes |
in |
T9956 |
42341-42344 |
DT |
denotes |
the |
T9957 |
42355-42359 |
NN |
denotes |
bulb |
T9958 |
42345-42354 |
JJ |
denotes |
olfactory |
T9959 |
42360-42361 |
-LRB- |
denotes |
[ |
T9960 |
42364-42366 |
CD |
denotes |
65 |
T9961 |
42361-42363 |
CD |
denotes |
64 |
T9962 |
42363-42364 |
, |
denotes |
, |
T9963 |
42366-42367 |
-RRB- |
denotes |
] |
T9964 |
42367-42368 |
. |
denotes |
. |
T9965 |
42368-42662 |
sentence |
denotes |
As Ca2+ influx through glutamate receptors is thought to contribute to lateral and recurrent inhibition ([38] see also [39]), the absence of GluR-B, or the presence of GluR-B(Q) in the olfactory bulb, is likely to result in increased inhibition between the principal neurons in this structure. |
T9966 |
42369-42371 |
IN |
denotes |
As |
T9967 |
42415-42422 |
VBN |
denotes |
thought |
T9968 |
42372-42375 |
NN |
denotes |
Ca2 |
T9969 |
42377-42383 |
NN |
denotes |
influx |
T9970 |
42375-42376 |
SYM |
denotes |
+ |
T9971 |
42384-42391 |
IN |
denotes |
through |
T9972 |
42392-42401 |
NN |
denotes |
glutamate |
T9973 |
42402-42411 |
NNS |
denotes |
receptors |
T9974 |
42412-42414 |
VBZ |
denotes |
is |
T9975 |
42570-42572 |
VBZ |
denotes |
is |
T9976 |
42423-42425 |
TO |
denotes |
to |
T9977 |
42426-42436 |
VB |
denotes |
contribute |
T9978 |
42437-42439 |
IN |
denotes |
to |
T9979 |
42440-42447 |
JJ |
denotes |
lateral |
T9980 |
42462-42472 |
NN |
denotes |
inhibition |
T9981 |
42448-42451 |
CC |
denotes |
and |
T9982 |
42452-42461 |
JJ |
denotes |
recurrent |
T9983 |
42473-42474 |
-LRB- |
denotes |
( |
T9984 |
42475-42477 |
CD |
denotes |
38 |
T9985 |
42474-42475 |
-LRB- |
denotes |
[ |
T9986 |
42477-42478 |
-RRB- |
denotes |
] |
T9987 |
42479-42482 |
VBP |
denotes |
see |
T9988 |
42483-42487 |
RB |
denotes |
also |
T9989 |
42488-42489 |
-LRB- |
denotes |
[ |
T9990 |
42489-42491 |
CD |
denotes |
39 |
T9991 |
42491-42492 |
-RRB- |
denotes |
] |
T9992 |
42492-42493 |
-RRB- |
denotes |
) |
T9993 |
42493-42495 |
, |
denotes |
, |
T9994 |
42495-42498 |
DT |
denotes |
the |
T9995 |
42499-42506 |
NN |
denotes |
absence |
T9996 |
42507-42509 |
IN |
denotes |
of |
T9997 |
42510-42514 |
NN |
denotes |
GluR |
T9998 |
42515-42516 |
NN |
denotes |
B |
T9999 |
42514-42515 |
HYPH |
denotes |
- |
T10000 |
42516-42518 |
, |
denotes |
, |
T10001 |
42518-42520 |
CC |
denotes |
or |
T10002 |
42521-42524 |
DT |
denotes |
the |
T10003 |
42525-42533 |
NN |
denotes |
presence |
T10004 |
42534-42536 |
IN |
denotes |
of |
T10005 |
42537-42541 |
NN |
denotes |
GluR |
T10006 |
42542-42543 |
NN |
denotes |
B |
T10007 |
42541-42542 |
HYPH |
denotes |
- |
T10008 |
42543-42544 |
-LRB- |
denotes |
( |
T10009 |
42544-42545 |
NN |
denotes |
Q |
T10010 |
42545-42546 |
-RRB- |
denotes |
) |
T10011 |
42547-42549 |
IN |
denotes |
in |
T10012 |
42550-42553 |
DT |
denotes |
the |
T10013 |
42564-42568 |
NN |
denotes |
bulb |
T10014 |
42554-42563 |
JJ |
denotes |
olfactory |
T10015 |
42568-42570 |
, |
denotes |
, |
T10016 |
42573-42579 |
JJ |
denotes |
likely |
T10017 |
42580-42582 |
TO |
denotes |
to |
T10018 |
42583-42589 |
VB |
denotes |
result |
T10019 |
42590-42592 |
IN |
denotes |
in |
T10020 |
42593-42602 |
VBN |
denotes |
increased |
T10021 |
42603-42613 |
NN |
denotes |
inhibition |
T10022 |
42614-42621 |
IN |
denotes |
between |
T10023 |
42622-42625 |
DT |
denotes |
the |
T10024 |
42636-42643 |
NNS |
denotes |
neurons |
T10025 |
42626-42635 |
JJ |
denotes |
principal |
T10026 |
42644-42646 |
IN |
denotes |
in |
T10027 |
42647-42651 |
DT |
denotes |
this |
T10028 |
42652-42661 |
NN |
denotes |
structure |
T10029 |
42661-42662 |
. |
denotes |
. |
T10030 |
42662-42792 |
sentence |
denotes |
Notably, the improved olfactory discrimination capabilities were apparent even upon relatively small reductions in GluR-B levels. |
T10031 |
42663-42670 |
RB |
denotes |
Notably |
T10032 |
42723-42727 |
VBD |
denotes |
were |
T10033 |
42670-42672 |
, |
denotes |
, |
T10034 |
42672-42675 |
DT |
denotes |
the |
T10035 |
42710-42722 |
NNS |
denotes |
capabilities |
T10036 |
42676-42684 |
VBN |
denotes |
improved |
T10037 |
42685-42694 |
JJ |
denotes |
olfactory |
T10038 |
42695-42709 |
NN |
denotes |
discrimination |
T10039 |
42728-42736 |
JJ |
denotes |
apparent |
T10040 |
42737-42741 |
RB |
denotes |
even |
T10041 |
42742-42746 |
IN |
denotes |
upon |
T10042 |
42747-42757 |
RB |
denotes |
relatively |
T10043 |
42758-42763 |
JJ |
denotes |
small |
T10044 |
42764-42774 |
NNS |
denotes |
reductions |
T10045 |
42775-42777 |
IN |
denotes |
in |
T10046 |
42778-42782 |
NN |
denotes |
GluR |
T10047 |
42783-42784 |
NN |
denotes |
B |
T10048 |
42782-42783 |
HYPH |
denotes |
- |
T10049 |
42785-42791 |
NNS |
denotes |
levels |
T10050 |
42791-42792 |
. |
denotes |
. |
T10051 |
42792-43154 |
sentence |
denotes |
It will be interesting to see if GluR-B+/neo mice also exhibit enhanced odor discrimination, which is indeed likely given that low levels of GluR-B(Q), and hence a small increase in Ca2+-permeable AMPARs, arise from the attenuated GluR-Bneo allele [60], and, moreover, that GluR-B levels are decreased in these mice due to the single copy of the GluR-B+ allele. |
T10052 |
42793-42795 |
PRP |
denotes |
It |
T10053 |
42801-42803 |
VB |
denotes |
be |
T10054 |
42796-42800 |
MD |
denotes |
will |
T10055 |
42804-42815 |
JJ |
denotes |
interesting |
T10056 |
42816-42818 |
TO |
denotes |
to |
T10057 |
42819-42822 |
VB |
denotes |
see |
T10058 |
42823-42825 |
IN |
denotes |
if |
T10059 |
42848-42855 |
VBP |
denotes |
exhibit |
T10060 |
42826-42830 |
NN |
denotes |
GluR |
T10061 |
42831-42832 |
NN |
denotes |
B |
T10062 |
42830-42831 |
HYPH |
denotes |
- |
T10063 |
42838-42842 |
NNS |
denotes |
mice |
T10064 |
42832-42833 |
SYM |
denotes |
+ |
T10065 |
42833-42834 |
HYPH |
denotes |
/ |
T10066 |
42834-42837 |
NN |
denotes |
neo |
T10067 |
42843-42847 |
RB |
denotes |
also |
T10068 |
42856-42864 |
VBN |
denotes |
enhanced |
T10069 |
42870-42884 |
NN |
denotes |
discrimination |
T10070 |
42865-42869 |
NN |
denotes |
odor |
T10071 |
42884-42886 |
, |
denotes |
, |
T10072 |
42886-42891 |
WDT |
denotes |
which |
T10073 |
42892-42894 |
VBZ |
denotes |
is |
T10074 |
42895-42901 |
RB |
denotes |
indeed |
T10075 |
42902-42908 |
JJ |
denotes |
likely |
T10076 |
42909-42914 |
JJ |
denotes |
given |
T10077 |
42915-42919 |
IN |
denotes |
that |
T10078 |
42998-43003 |
VBP |
denotes |
arise |
T10079 |
42920-42923 |
JJ |
denotes |
low |
T10080 |
42924-42930 |
NNS |
denotes |
levels |
T10081 |
42931-42933 |
IN |
denotes |
of |
T10082 |
42934-42938 |
NN |
denotes |
GluR |
T10083 |
42941-42942 |
NN |
denotes |
Q |
T10084 |
42938-42939 |
HYPH |
denotes |
- |
T10085 |
42939-42940 |
NN |
denotes |
B |
T10086 |
42940-42941 |
-LRB- |
denotes |
( |
T10087 |
42942-42943 |
-RRB- |
denotes |
) |
T10088 |
42943-42945 |
, |
denotes |
, |
T10089 |
42945-42948 |
CC |
denotes |
and |
T10090 |
42949-42954 |
RB |
denotes |
hence |
T10091 |
42963-42971 |
NN |
denotes |
increase |
T10092 |
42955-42956 |
DT |
denotes |
a |
T10093 |
42957-42962 |
JJ |
denotes |
small |
T10094 |
42972-42974 |
IN |
denotes |
in |
T10095 |
42975-42978 |
NN |
denotes |
Ca2 |
T10096 |
42980-42989 |
JJ |
denotes |
permeable |
T10097 |
42978-42979 |
SYM |
denotes |
+ |
T10098 |
42979-42980 |
HYPH |
denotes |
- |
T10099 |
42990-42996 |
NNS |
denotes |
AMPARs |
T10100 |
42996-42998 |
, |
denotes |
, |
T10101 |
43004-43008 |
IN |
denotes |
from |
T10102 |
43009-43012 |
DT |
denotes |
the |
T10103 |
43034-43040 |
NN |
denotes |
allele |
T10104 |
43013-43023 |
VBN |
denotes |
attenuated |
T10105 |
43024-43028 |
NN |
denotes |
GluR |
T10106 |
43029-43033 |
NN |
denotes |
Bneo |
T10107 |
43028-43029 |
HYPH |
denotes |
- |
T10108 |
43041-43042 |
-LRB- |
denotes |
[ |
T10109 |
43042-43044 |
CD |
denotes |
60 |
T10110 |
43044-43045 |
-RRB- |
denotes |
] |
T10111 |
43045-43047 |
, |
denotes |
, |
T10112 |
43047-43050 |
CC |
denotes |
and |
T10113 |
43050-43052 |
, |
denotes |
, |
T10114 |
43052-43060 |
RB |
denotes |
moreover |
T10115 |
43085-43094 |
VBN |
denotes |
decreased |
T10116 |
43060-43062 |
, |
denotes |
, |
T10117 |
43062-43066 |
IN |
denotes |
that |
T10118 |
43067-43071 |
NN |
denotes |
GluR |
T10119 |
43072-43073 |
NN |
denotes |
B |
T10120 |
43071-43072 |
HYPH |
denotes |
- |
T10121 |
43074-43080 |
NNS |
denotes |
levels |
T10122 |
43081-43084 |
VBP |
denotes |
are |
T10123 |
43095-43097 |
IN |
denotes |
in |
T10124 |
43098-43103 |
DT |
denotes |
these |
T10125 |
43104-43108 |
NNS |
denotes |
mice |
T10126 |
43109-43112 |
IN |
denotes |
due |
T10127 |
43113-43115 |
IN |
denotes |
to |
T10128 |
43116-43119 |
DT |
denotes |
the |
T10129 |
43127-43131 |
NN |
denotes |
copy |
T10130 |
43120-43126 |
JJ |
denotes |
single |
T10131 |
43132-43134 |
IN |
denotes |
of |
T10132 |
43135-43138 |
DT |
denotes |
the |
T10133 |
43147-43153 |
NN |
denotes |
allele |
T10134 |
43139-43143 |
NN |
denotes |
GluR |
T10135 |
43144-43145 |
NN |
denotes |
B |
T10136 |
43143-43144 |
HYPH |
denotes |
- |
T10137 |
43145-43146 |
SYM |
denotes |
+ |
T10138 |
43153-43154 |
. |
denotes |
. |
T10139 |
43154-43464 |
sentence |
denotes |
In virtually all models of the olfactory bulb, lateral (and, in fewer models, also recurrent) inhibition plays a dominant role, either in establishing spatiotemporal dynamics [32,66–69], or in directly enhancing contrast and therefore simplifying discrimination and learning of similar odorants [24,28,29,36]. |
T10140 |
43155-43157 |
IN |
denotes |
In |
T10141 |
43260-43265 |
VBZ |
denotes |
plays |
T10142 |
43158-43167 |
RB |
denotes |
virtually |
T10143 |
43172-43178 |
NNS |
denotes |
models |
T10144 |
43168-43171 |
DT |
denotes |
all |
T10145 |
43179-43181 |
IN |
denotes |
of |
T10146 |
43182-43185 |
DT |
denotes |
the |
T10147 |
43196-43200 |
NN |
denotes |
bulb |
T10148 |
43186-43195 |
JJ |
denotes |
olfactory |
T10149 |
43200-43202 |
, |
denotes |
, |
T10150 |
43202-43209 |
JJ |
denotes |
lateral |
T10151 |
43249-43259 |
NN |
denotes |
inhibition |
T10152 |
43210-43211 |
-LRB- |
denotes |
( |
T10153 |
43211-43214 |
CC |
denotes |
and |
T10154 |
43214-43216 |
, |
denotes |
, |
T10155 |
43216-43218 |
IN |
denotes |
in |
T10156 |
43238-43247 |
JJ |
denotes |
recurrent |
T10157 |
43219-43224 |
JJR |
denotes |
fewer |
T10158 |
43225-43231 |
NNS |
denotes |
models |
T10159 |
43231-43233 |
, |
denotes |
, |
T10160 |
43233-43237 |
RB |
denotes |
also |
T10161 |
43247-43248 |
-RRB- |
denotes |
) |
T10162 |
43266-43267 |
DT |
denotes |
a |
T10163 |
43277-43281 |
NN |
denotes |
role |
T10164 |
43268-43276 |
JJ |
denotes |
dominant |
T10165 |
43281-43283 |
, |
denotes |
, |
T10166 |
43283-43289 |
CC |
denotes |
either |
T10167 |
43290-43292 |
IN |
denotes |
in |
T10168 |
43293-43305 |
VBG |
denotes |
establishing |
T10169 |
43306-43320 |
JJ |
denotes |
spatiotemporal |
T10170 |
43321-43329 |
NNS |
denotes |
dynamics |
T10171 |
43330-43331 |
-LRB- |
denotes |
[ |
T10172 |
43334-43336 |
CD |
denotes |
66 |
T10173 |
43331-43333 |
CD |
denotes |
32 |
T10174 |
43333-43334 |
, |
denotes |
, |
T10175 |
43336-43337 |
SYM |
denotes |
– |
T10176 |
43337-43339 |
CD |
denotes |
69 |
T10177 |
43339-43340 |
-RRB- |
denotes |
] |
T10178 |
43340-43342 |
, |
denotes |
, |
T10179 |
43342-43344 |
CC |
denotes |
or |
T10180 |
43345-43347 |
IN |
denotes |
in |
T10181 |
43348-43356 |
RB |
denotes |
directly |
T10182 |
43357-43366 |
VBG |
denotes |
enhancing |
T10183 |
43367-43375 |
NN |
denotes |
contrast |
T10184 |
43376-43379 |
CC |
denotes |
and |
T10185 |
43380-43389 |
RB |
denotes |
therefore |
T10186 |
43390-43401 |
VBG |
denotes |
simplifying |
T10187 |
43402-43416 |
NN |
denotes |
discrimination |
T10188 |
43417-43420 |
CC |
denotes |
and |
T10189 |
43421-43429 |
NN |
denotes |
learning |
T10190 |
43430-43432 |
IN |
denotes |
of |
T10191 |
43433-43440 |
JJ |
denotes |
similar |
T10192 |
43441-43449 |
NNS |
denotes |
odorants |
T10193 |
43450-43451 |
-LRB- |
denotes |
[ |
T10194 |
43460-43462 |
CD |
denotes |
36 |
T10195 |
43451-43453 |
CD |
denotes |
24 |
T10196 |
43453-43454 |
, |
denotes |
, |
T10197 |
43454-43456 |
CD |
denotes |
28 |
T10198 |
43456-43457 |
, |
denotes |
, |
T10199 |
43457-43459 |
CD |
denotes |
29 |
T10200 |
43459-43460 |
, |
denotes |
, |
T10201 |
43462-43463 |
-RRB- |
denotes |
] |
T10202 |
43463-43464 |
. |
denotes |
. |
T10203 |
43464-43656 |
sentence |
denotes |
Increased inhibition will thus in general improve discriminability, consistent with the behavioral improvements observed with GluR-B(Q) expression, the GluR-B knockout, and the “rescue” mice. |
T10204 |
43465-43474 |
VBN |
denotes |
Increased |
T10205 |
43475-43485 |
NN |
denotes |
inhibition |
T10206 |
43507-43514 |
VB |
denotes |
improve |
T10207 |
43486-43490 |
MD |
denotes |
will |
T10208 |
43491-43495 |
RB |
denotes |
thus |
T10209 |
43496-43498 |
IN |
denotes |
in |
T10210 |
43499-43506 |
JJ |
denotes |
general |
T10211 |
43515-43531 |
NN |
denotes |
discriminability |
T10212 |
43531-43533 |
, |
denotes |
, |
T10213 |
43533-43543 |
JJ |
denotes |
consistent |
T10214 |
43544-43548 |
IN |
denotes |
with |
T10215 |
43549-43552 |
DT |
denotes |
the |
T10216 |
43564-43576 |
NNS |
denotes |
improvements |
T10217 |
43553-43563 |
JJ |
denotes |
behavioral |
T10218 |
43577-43585 |
VBN |
denotes |
observed |
T10219 |
43586-43590 |
IN |
denotes |
with |
T10220 |
43591-43595 |
NN |
denotes |
GluR |
T10221 |
43598-43599 |
NN |
denotes |
Q |
T10222 |
43595-43596 |
HYPH |
denotes |
- |
T10223 |
43596-43597 |
NN |
denotes |
B |
T10224 |
43597-43598 |
-LRB- |
denotes |
( |
T10225 |
43601-43611 |
NN |
denotes |
expression |
T10226 |
43599-43600 |
-RRB- |
denotes |
) |
T10227 |
43611-43613 |
, |
denotes |
, |
T10228 |
43613-43616 |
DT |
denotes |
the |
T10229 |
43624-43632 |
NN |
denotes |
knockout |
T10230 |
43617-43621 |
NN |
denotes |
GluR |
T10231 |
43622-43623 |
NN |
denotes |
B |
T10232 |
43621-43622 |
HYPH |
denotes |
- |
T10233 |
43632-43634 |
, |
denotes |
, |
T10234 |
43634-43637 |
CC |
denotes |
and |
T10235 |
43638-43641 |
DT |
denotes |
the |
T10236 |
43651-43655 |
NNS |
denotes |
mice |
T10237 |
43642-43643 |
`` |
denotes |
“ |
T10238 |
43643-43649 |
NN |
denotes |
rescue |
T10239 |
43649-43650 |
'' |
denotes |
” |
T10240 |
43655-43656 |
. |
denotes |
. |
T10241 |
43656-43962 |
sentence |
denotes |
A direct test of this link would require the quantitative measurement of inhibition in the intact preparation, a task that might be feasible with further improved in vivo electrophysiological techniques, such as targeted recordings [70,71] or simultaneous pre- and postsynaptic intracellular measurements. |
T10242 |
43657-43658 |
DT |
denotes |
A |
T10243 |
43666-43670 |
NN |
denotes |
test |
T10244 |
43659-43665 |
JJ |
denotes |
direct |
T10245 |
43690-43697 |
VB |
denotes |
require |
T10246 |
43671-43673 |
IN |
denotes |
of |
T10247 |
43674-43678 |
DT |
denotes |
this |
T10248 |
43679-43683 |
NN |
denotes |
link |
T10249 |
43684-43689 |
MD |
denotes |
would |
T10250 |
43698-43701 |
DT |
denotes |
the |
T10251 |
43715-43726 |
NN |
denotes |
measurement |
T10252 |
43702-43714 |
JJ |
denotes |
quantitative |
T10253 |
43727-43729 |
IN |
denotes |
of |
T10254 |
43730-43740 |
NN |
denotes |
inhibition |
T10255 |
43741-43743 |
IN |
denotes |
in |
T10256 |
43744-43747 |
DT |
denotes |
the |
T10257 |
43755-43766 |
NN |
denotes |
preparation |
T10258 |
43748-43754 |
JJ |
denotes |
intact |
T10259 |
43766-43768 |
, |
denotes |
, |
T10260 |
43768-43769 |
DT |
denotes |
a |
T10261 |
43770-43774 |
NN |
denotes |
task |
T10262 |
43775-43779 |
WDT |
denotes |
that |
T10263 |
43786-43788 |
VB |
denotes |
be |
T10264 |
43780-43785 |
MD |
denotes |
might |
T10265 |
43789-43797 |
JJ |
denotes |
feasible |
T10266 |
43798-43802 |
IN |
denotes |
with |
T10267 |
43803-43810 |
RB |
denotes |
further |
T10268 |
43811-43819 |
VBN |
denotes |
improved |
T10269 |
43849-43859 |
NNS |
denotes |
techniques |
T10270 |
43820-43822 |
FW |
denotes |
in |
T10271 |
43823-43827 |
FW |
denotes |
vivo |
T10272 |
43828-43848 |
JJ |
denotes |
electrophysiological |
T10273 |
43859-43861 |
, |
denotes |
, |
T10274 |
43861-43865 |
JJ |
denotes |
such |
T10275 |
43866-43868 |
IN |
denotes |
as |
T10276 |
43869-43877 |
VBN |
denotes |
targeted |
T10277 |
43878-43888 |
NNS |
denotes |
recordings |
T10278 |
43889-43890 |
-LRB- |
denotes |
[ |
T10279 |
43893-43895 |
CD |
denotes |
71 |
T10280 |
43890-43892 |
CD |
denotes |
70 |
T10281 |
43892-43893 |
, |
denotes |
, |
T10282 |
43895-43896 |
-RRB- |
denotes |
] |
T10283 |
43897-43899 |
CC |
denotes |
or |
T10284 |
43900-43912 |
JJ |
denotes |
simultaneous |
T10285 |
43949-43961 |
NNS |
denotes |
measurements |
T10286 |
43913-43916 |
AFX |
denotes |
pre |
T10287 |
43922-43934 |
JJ |
denotes |
postsynaptic |
T10288 |
43916-43917 |
HYPH |
denotes |
- |
T10289 |
43918-43921 |
CC |
denotes |
and |
T10290 |
43935-43948 |
JJ |
denotes |
intracellular |
T10291 |
43961-43962 |
. |
denotes |
. |
T10675 |
43964-43973 |
JJ |
denotes |
Olfactory |
T10676 |
43974-43980 |
NN |
denotes |
Memory |
T10677 |
43984-43991 |
VBN |
denotes |
Reduced |
T10678 |
43981-43983 |
VBZ |
denotes |
Is |
T10679 |
43992-43994 |
IN |
denotes |
in |
T10680 |
43995-43999 |
NN |
denotes |
GluR |
T10681 |
44000-44001 |
NN |
denotes |
B |
T10682 |
43999-44000 |
HYPH |
denotes |
- |
T10683 |
44011-44015 |
NNS |
denotes |
Mice |
T10684 |
44002-44010 |
NN |
denotes |
Knockout |
T10685 |
44016-44019 |
CC |
denotes |
and |
T10686 |
44020-44028 |
VBN |
denotes |
Improved |
T10687 |
44029-44031 |
IN |
denotes |
by |
T10688 |
44032-44036 |
NN |
denotes |
GluR |
T10689 |
44037-44038 |
NN |
denotes |
B |
T10690 |
44036-44037 |
HYPH |
denotes |
- |
T10691 |
44039-44049 |
NN |
denotes |
Expression |
T10692 |
44050-44052 |
IN |
denotes |
in |
T10693 |
44053-44061 |
JJ |
denotes |
Piriform |
T10694 |
44062-44068 |
NN |
denotes |
Cortex |
T10695 |
44069-44072 |
CC |
denotes |
and |
T10696 |
44073-44084 |
NN |
denotes |
Hippocampus |
T10697 |
44084-44248 |
sentence |
denotes |
To assess olfactory memory of GluR-BΔFB mice, after six days the mice were probed with unrewarded odor presentations that interleaved a simple discrimination task. |
T10698 |
44085-44087 |
TO |
denotes |
To |
T10699 |
44088-44094 |
VB |
denotes |
assess |
T10700 |
44160-44166 |
VBN |
denotes |
probed |
T10701 |
44095-44104 |
JJ |
denotes |
olfactory |
T10702 |
44105-44111 |
NN |
denotes |
memory |
T10703 |
44112-44114 |
IN |
denotes |
of |
T10704 |
44115-44119 |
NN |
denotes |
GluR |
T10705 |
44120-44124 |
NN |
denotes |
BΔFB |
T10706 |
44119-44120 |
HYPH |
denotes |
- |
T10707 |
44125-44129 |
NNS |
denotes |
mice |
T10708 |
44129-44131 |
, |
denotes |
, |
T10709 |
44131-44136 |
IN |
denotes |
after |
T10710 |
44137-44140 |
CD |
denotes |
six |
T10711 |
44141-44145 |
NNS |
denotes |
days |
T10712 |
44146-44149 |
DT |
denotes |
the |
T10713 |
44150-44154 |
NNS |
denotes |
mice |
T10714 |
44155-44159 |
VBD |
denotes |
were |
T10715 |
44167-44171 |
IN |
denotes |
with |
T10716 |
44172-44182 |
JJ |
denotes |
unrewarded |
T10717 |
44188-44201 |
NNS |
denotes |
presentations |
T10718 |
44183-44187 |
NN |
denotes |
odor |
T10719 |
44202-44206 |
WDT |
denotes |
that |
T10720 |
44207-44218 |
VBD |
denotes |
interleaved |
T10721 |
44219-44220 |
DT |
denotes |
a |
T10722 |
44243-44247 |
NN |
denotes |
task |
T10723 |
44221-44227 |
JJ |
denotes |
simple |
T10724 |
44228-44242 |
NN |
denotes |
discrimination |
T10725 |
44247-44248 |
. |
denotes |
. |
T10726 |
44248-44390 |
sentence |
denotes |
Prolonged behavioral tasks such as the assessment of long-term olfactory memory were not performed with the seizure-prone GluR-BΔECS:FB mice. |
T10727 |
44249-44258 |
VBN |
denotes |
Prolonged |
T10728 |
44270-44275 |
NNS |
denotes |
tasks |
T10729 |
44259-44269 |
JJ |
denotes |
behavioral |
T10730 |
44338-44347 |
VBN |
denotes |
performed |
T10731 |
44276-44280 |
JJ |
denotes |
such |
T10732 |
44281-44283 |
IN |
denotes |
as |
T10733 |
44284-44287 |
DT |
denotes |
the |
T10734 |
44288-44298 |
NN |
denotes |
assessment |
T10735 |
44299-44301 |
IN |
denotes |
of |
T10736 |
44302-44306 |
JJ |
denotes |
long |
T10737 |
44307-44311 |
NN |
denotes |
term |
T10738 |
44306-44307 |
HYPH |
denotes |
- |
T10739 |
44322-44328 |
NN |
denotes |
memory |
T10740 |
44312-44321 |
JJ |
denotes |
olfactory |
T10741 |
44329-44333 |
VBD |
denotes |
were |
T10742 |
44334-44337 |
RB |
denotes |
not |
T10743 |
44348-44352 |
IN |
denotes |
with |
T10744 |
44353-44356 |
DT |
denotes |
the |
T10745 |
44385-44389 |
NNS |
denotes |
mice |
T10746 |
44357-44364 |
NN |
denotes |
seizure |
T10747 |
44365-44370 |
JJ |
denotes |
prone |
T10748 |
44364-44365 |
HYPH |
denotes |
- |
T10749 |
44371-44375 |
NN |
denotes |
GluR |
T10750 |
44376-44381 |
NN |
denotes |
BΔECS |
T10751 |
44375-44376 |
HYPH |
denotes |
- |
T10752 |
44381-44382 |
: |
denotes |
: |
T10753 |
44382-44384 |
NN |
denotes |
FB |
T10754 |
44389-44390 |
. |
denotes |
. |
T10755 |
44390-44452 |
sentence |
denotes |
Memory in GluR-BΔFB mice, however, was dramatically impaired. |
T10756 |
44391-44397 |
NN |
denotes |
Memory |
T10757 |
44443-44451 |
VBN |
denotes |
impaired |
T10758 |
44398-44400 |
IN |
denotes |
in |
T10759 |
44401-44405 |
NN |
denotes |
GluR |
T10760 |
44406-44410 |
NN |
denotes |
BΔFB |
T10761 |
44405-44406 |
HYPH |
denotes |
- |
T10762 |
44411-44415 |
NNS |
denotes |
mice |
T10763 |
44415-44417 |
, |
denotes |
, |
T10764 |
44417-44424 |
RB |
denotes |
however |
T10765 |
44424-44426 |
, |
denotes |
, |
T10766 |
44426-44429 |
VBD |
denotes |
was |
T10767 |
44430-44442 |
RB |
denotes |
dramatically |
T10768 |
44451-44452 |
. |
denotes |
. |
T10769 |
44452-44640 |
sentence |
denotes |
This cannot be attributed to a general, unspecific deficit because, simultaneous to the memory trials, the normal, rewarded discrimination task was performed even better than by controls. |
T10770 |
44453-44457 |
DT |
denotes |
This |
T10771 |
44468-44478 |
VBN |
denotes |
attributed |
T10772 |
44458-44461 |
MD |
denotes |
can |
T10773 |
44461-44464 |
RB |
denotes |
not |
T10774 |
44465-44467 |
VB |
denotes |
be |
T10775 |
44479-44481 |
IN |
denotes |
to |
T10776 |
44482-44483 |
DT |
denotes |
a |
T10777 |
44504-44511 |
NN |
denotes |
deficit |
T10778 |
44484-44491 |
JJ |
denotes |
general |
T10779 |
44491-44493 |
, |
denotes |
, |
T10780 |
44493-44503 |
JJ |
denotes |
unspecific |
T10781 |
44512-44519 |
IN |
denotes |
because |
T10782 |
44601-44610 |
VBN |
denotes |
performed |
T10783 |
44519-44521 |
, |
denotes |
, |
T10784 |
44521-44533 |
JJ |
denotes |
simultaneous |
T10785 |
44534-44536 |
IN |
denotes |
to |
T10786 |
44537-44540 |
DT |
denotes |
the |
T10787 |
44548-44554 |
NNS |
denotes |
trials |
T10788 |
44541-44547 |
NN |
denotes |
memory |
T10789 |
44554-44556 |
, |
denotes |
, |
T10790 |
44556-44559 |
DT |
denotes |
the |
T10791 |
44592-44596 |
NN |
denotes |
task |
T10792 |
44560-44566 |
JJ |
denotes |
normal |
T10793 |
44566-44568 |
, |
denotes |
, |
T10794 |
44568-44576 |
VBN |
denotes |
rewarded |
T10795 |
44577-44591 |
NN |
denotes |
discrimination |
T10796 |
44597-44600 |
VBD |
denotes |
was |
T10797 |
44611-44615 |
RB |
denotes |
even |
T10798 |
44616-44622 |
RBR |
denotes |
better |
T10799 |
44623-44627 |
IN |
denotes |
than |
T10800 |
44628-44630 |
IN |
denotes |
by |
T10801 |
44631-44639 |
NNS |
denotes |
controls |
T10802 |
44639-44640 |
. |
denotes |
. |
T10803 |
44640-44898 |
sentence |
denotes |
Reduced olfactory memory can also not be simply attributed to increased extinction, as no significant trial-group interactions were observed and also, when restricted to the first unrewarded memory trials, a significant impairment was observed (Figure S3A). |
T10804 |
44641-44648 |
VBN |
denotes |
Reduced |
T10805 |
44659-44665 |
NN |
denotes |
memory |
T10806 |
44649-44658 |
JJ |
denotes |
olfactory |
T10807 |
44689-44699 |
VBN |
denotes |
attributed |
T10808 |
44666-44669 |
MD |
denotes |
can |
T10809 |
44670-44674 |
RB |
denotes |
also |
T10810 |
44675-44678 |
RB |
denotes |
not |
T10811 |
44679-44681 |
VB |
denotes |
be |
T10812 |
44682-44688 |
RB |
denotes |
simply |
T10813 |
44700-44702 |
IN |
denotes |
to |
T10814 |
44703-44712 |
VBN |
denotes |
increased |
T10815 |
44713-44723 |
NN |
denotes |
extinction |
T10816 |
44723-44725 |
, |
denotes |
, |
T10817 |
44725-44727 |
IN |
denotes |
as |
T10818 |
44773-44781 |
VBN |
denotes |
observed |
T10819 |
44728-44730 |
DT |
denotes |
no |
T10820 |
44755-44767 |
NNS |
denotes |
interactions |
T10821 |
44731-44742 |
JJ |
denotes |
significant |
T10822 |
44743-44748 |
NN |
denotes |
trial |
T10823 |
44749-44754 |
NN |
denotes |
group |
T10824 |
44748-44749 |
HYPH |
denotes |
- |
T10825 |
44768-44772 |
VBD |
denotes |
were |
T10826 |
44782-44785 |
CC |
denotes |
and |
T10827 |
44786-44790 |
RB |
denotes |
also |
T10828 |
44876-44884 |
VBN |
denotes |
observed |
T10829 |
44790-44792 |
, |
denotes |
, |
T10830 |
44792-44796 |
WRB |
denotes |
when |
T10831 |
44797-44807 |
VBN |
denotes |
restricted |
T10832 |
44808-44810 |
IN |
denotes |
to |
T10833 |
44811-44814 |
DT |
denotes |
the |
T10834 |
44839-44845 |
NNS |
denotes |
trials |
T10835 |
44815-44820 |
JJ |
denotes |
first |
T10836 |
44821-44831 |
JJ |
denotes |
unrewarded |
T10837 |
44832-44838 |
NN |
denotes |
memory |
T10838 |
44845-44847 |
, |
denotes |
, |
T10839 |
44847-44848 |
DT |
denotes |
a |
T10840 |
44861-44871 |
NN |
denotes |
impairment |
T10841 |
44849-44860 |
JJ |
denotes |
significant |
T10842 |
44872-44875 |
VBD |
denotes |
was |
T10843 |
44885-44886 |
-LRB- |
denotes |
( |
T10844 |
44893-44896 |
NN |
denotes |
S3A |
T10845 |
44886-44892 |
NN |
denotes |
Figure |
T10846 |
44896-44897 |
-RRB- |
denotes |
) |
T10847 |
44897-44898 |
. |
denotes |
. |
T10848 |
44898-45108 |
sentence |
denotes |
Additionally, investigating relearning of the first discrimination task revealed a significant correlation with the memory performance, showing a “memory” deficit under extinction-free conditions (Figure S3B). |
T10849 |
44899-44911 |
RB |
denotes |
Additionally |
T10850 |
44971-44979 |
VBD |
denotes |
revealed |
T10851 |
44911-44913 |
, |
denotes |
, |
T10852 |
44913-44926 |
VBG |
denotes |
investigating |
T10853 |
44927-44937 |
NN |
denotes |
relearning |
T10854 |
44938-44940 |
IN |
denotes |
of |
T10855 |
44941-44944 |
DT |
denotes |
the |
T10856 |
44966-44970 |
NN |
denotes |
task |
T10857 |
44945-44950 |
JJ |
denotes |
first |
T10858 |
44951-44965 |
NN |
denotes |
discrimination |
T10859 |
44980-44981 |
DT |
denotes |
a |
T10860 |
44994-45005 |
NN |
denotes |
correlation |
T10861 |
44982-44993 |
JJ |
denotes |
significant |
T10862 |
45006-45010 |
IN |
denotes |
with |
T10863 |
45011-45014 |
DT |
denotes |
the |
T10864 |
45022-45033 |
NN |
denotes |
performance |
T10865 |
45015-45021 |
NN |
denotes |
memory |
T10866 |
45033-45035 |
, |
denotes |
, |
T10867 |
45035-45042 |
VBG |
denotes |
showing |
T10868 |
45043-45044 |
DT |
denotes |
a |
T10869 |
45054-45061 |
NN |
denotes |
deficit |
T10870 |
45045-45046 |
`` |
denotes |
“ |
T10871 |
45046-45052 |
NN |
denotes |
memory |
T10872 |
45052-45053 |
'' |
denotes |
” |
T10873 |
45062-45067 |
IN |
denotes |
under |
T10874 |
45068-45078 |
NN |
denotes |
extinction |
T10875 |
45079-45083 |
JJ |
denotes |
free |
T10876 |
45078-45079 |
HYPH |
denotes |
- |
T10877 |
45084-45094 |
NNS |
denotes |
conditions |
T10878 |
45095-45096 |
-LRB- |
denotes |
( |
T10879 |
45103-45106 |
NN |
denotes |
S3B |
T10880 |
45096-45102 |
NN |
denotes |
Figure |
T10881 |
45106-45107 |
-RRB- |
denotes |
) |
T10882 |
45107-45108 |
. |
denotes |
. |
T10883 |
45108-45292 |
sentence |
denotes |
Finally, in other memory-related tasks, such as a hippocampus-dependent spatial reference memory task (Figure S2), mice with GluR-B depletion were not impaired after task acquisition. |
T10884 |
45109-45116 |
RB |
denotes |
Finally |
T10885 |
45260-45268 |
VBN |
denotes |
impaired |
T10886 |
45116-45118 |
, |
denotes |
, |
T10887 |
45118-45120 |
IN |
denotes |
in |
T10888 |
45121-45126 |
JJ |
denotes |
other |
T10889 |
45142-45147 |
NNS |
denotes |
tasks |
T10890 |
45127-45133 |
NN |
denotes |
memory |
T10891 |
45134-45141 |
VBN |
denotes |
related |
T10892 |
45133-45134 |
HYPH |
denotes |
- |
T10893 |
45147-45149 |
, |
denotes |
, |
T10894 |
45149-45153 |
JJ |
denotes |
such |
T10895 |
45154-45156 |
IN |
denotes |
as |
T10896 |
45157-45158 |
DT |
denotes |
a |
T10897 |
45206-45210 |
NN |
denotes |
task |
T10898 |
45159-45170 |
NN |
denotes |
hippocampus |
T10899 |
45171-45180 |
JJ |
denotes |
dependent |
T10900 |
45170-45171 |
HYPH |
denotes |
- |
T10901 |
45181-45188 |
JJ |
denotes |
spatial |
T10902 |
45189-45198 |
NN |
denotes |
reference |
T10903 |
45199-45205 |
NN |
denotes |
memory |
T10904 |
45211-45212 |
-LRB- |
denotes |
( |
T10905 |
45219-45221 |
NN |
denotes |
S2 |
T10906 |
45212-45218 |
NN |
denotes |
Figure |
T10907 |
45221-45222 |
-RRB- |
denotes |
) |
T10908 |
45222-45224 |
, |
denotes |
, |
T10909 |
45224-45228 |
NNS |
denotes |
mice |
T10910 |
45229-45233 |
IN |
denotes |
with |
T10911 |
45234-45238 |
NN |
denotes |
GluR |
T10912 |
45239-45240 |
NN |
denotes |
B |
T10913 |
45238-45239 |
HYPH |
denotes |
- |
T10914 |
45241-45250 |
NN |
denotes |
depletion |
T10915 |
45251-45255 |
VBD |
denotes |
were |
T10916 |
45256-45259 |
RB |
denotes |
not |
T10917 |
45269-45274 |
IN |
denotes |
after |
T10918 |
45275-45279 |
NN |
denotes |
task |
T10919 |
45280-45291 |
NN |
denotes |
acquisition |
T10920 |
45291-45292 |
. |
denotes |
. |
T10921 |
45292-45496 |
sentence |
denotes |
We therefore conclude that forebrain-specific ablation of GluR-B results in a specific loss of long-term olfactory memory but, at the same time, in enhanced odor discrimination and learning capabilities. |
T10922 |
45293-45295 |
PRP |
denotes |
We |
T10923 |
45306-45314 |
VBP |
denotes |
conclude |
T10924 |
45296-45305 |
RB |
denotes |
therefore |
T10925 |
45315-45319 |
IN |
denotes |
that |
T10926 |
45358-45365 |
VBZ |
denotes |
results |
T10927 |
45320-45329 |
NN |
denotes |
forebrain |
T10928 |
45330-45338 |
JJ |
denotes |
specific |
T10929 |
45329-45330 |
HYPH |
denotes |
- |
T10930 |
45339-45347 |
NN |
denotes |
ablation |
T10931 |
45348-45350 |
IN |
denotes |
of |
T10932 |
45351-45355 |
NN |
denotes |
GluR |
T10933 |
45356-45357 |
NN |
denotes |
B |
T10934 |
45355-45356 |
HYPH |
denotes |
- |
T10935 |
45366-45368 |
IN |
denotes |
in |
T10936 |
45369-45370 |
DT |
denotes |
a |
T10937 |
45380-45384 |
NN |
denotes |
loss |
T10938 |
45371-45379 |
JJ |
denotes |
specific |
T10939 |
45385-45387 |
IN |
denotes |
of |
T10940 |
45388-45392 |
JJ |
denotes |
long |
T10941 |
45393-45397 |
NN |
denotes |
term |
T10942 |
45392-45393 |
HYPH |
denotes |
- |
T10943 |
45408-45414 |
NN |
denotes |
memory |
T10944 |
45398-45407 |
JJ |
denotes |
olfactory |
T10945 |
45415-45418 |
CC |
denotes |
but |
T10946 |
45418-45420 |
, |
denotes |
, |
T10947 |
45420-45422 |
IN |
denotes |
at |
T10948 |
45438-45440 |
IN |
denotes |
in |
T10949 |
45423-45426 |
DT |
denotes |
the |
T10950 |
45432-45436 |
NN |
denotes |
time |
T10951 |
45427-45431 |
JJ |
denotes |
same |
T10952 |
45436-45438 |
, |
denotes |
, |
T10953 |
45441-45449 |
VBN |
denotes |
enhanced |
T10954 |
45483-45495 |
NNS |
denotes |
capabilities |
T10955 |
45450-45454 |
NN |
denotes |
odor |
T10956 |
45455-45469 |
NN |
denotes |
discrimination |
T10957 |
45470-45473 |
CC |
denotes |
and |
T10958 |
45474-45482 |
NN |
denotes |
learning |
T10959 |
45495-45496 |
. |
denotes |
. |
T10960 |
45496-45676 |
sentence |
denotes |
To dissect the discrimination, learning, and memory phenotypes, and ultimately identify potential cellular correlates, we made use of the variegated Cre expression of TgCre4 mice. |
T10961 |
45497-45499 |
TO |
denotes |
To |
T10962 |
45500-45507 |
VB |
denotes |
dissect |
T10963 |
45619-45623 |
VBD |
denotes |
made |
T10964 |
45508-45511 |
DT |
denotes |
the |
T10965 |
45549-45559 |
NNS |
denotes |
phenotypes |
T10966 |
45512-45526 |
NN |
denotes |
discrimination |
T10967 |
45526-45528 |
, |
denotes |
, |
T10968 |
45528-45536 |
NN |
denotes |
learning |
T10969 |
45536-45538 |
, |
denotes |
, |
T10970 |
45538-45541 |
CC |
denotes |
and |
T10971 |
45542-45548 |
NN |
denotes |
memory |
T10972 |
45559-45561 |
, |
denotes |
, |
T10973 |
45561-45564 |
CC |
denotes |
and |
T10974 |
45565-45575 |
RB |
denotes |
ultimately |
T10975 |
45576-45584 |
VB |
denotes |
identify |
T10976 |
45585-45594 |
JJ |
denotes |
potential |
T10977 |
45604-45614 |
NNS |
denotes |
correlates |
T10978 |
45595-45603 |
JJ |
denotes |
cellular |
T10979 |
45614-45616 |
, |
denotes |
, |
T10980 |
45616-45618 |
PRP |
denotes |
we |
T10981 |
45624-45627 |
NN |
denotes |
use |
T10982 |
45628-45630 |
IN |
denotes |
of |
T10983 |
45631-45634 |
DT |
denotes |
the |
T10984 |
45650-45660 |
NN |
denotes |
expression |
T10985 |
45635-45645 |
JJ |
denotes |
variegated |
T10986 |
45646-45649 |
NN |
denotes |
Cre |
T10987 |
45661-45663 |
IN |
denotes |
of |
T10988 |
45664-45670 |
NN |
denotes |
TgCre4 |
T10989 |
45671-45675 |
NNS |
denotes |
mice |
T10990 |
45675-45676 |
. |
denotes |
. |
T10991 |
45676-45879 |
sentence |
denotes |
Therefore, residual GluR-B levels were determined from each mouse that had been tested in the behavioral experiments, and levels were correlated with odor learning, discrimination, and olfactory memory. |
T10992 |
45677-45686 |
RB |
denotes |
Therefore |
T10993 |
45716-45726 |
VBN |
denotes |
determined |
T10994 |
45686-45688 |
, |
denotes |
, |
T10995 |
45688-45696 |
JJ |
denotes |
residual |
T10996 |
45704-45710 |
NNS |
denotes |
levels |
T10997 |
45697-45701 |
NN |
denotes |
GluR |
T10998 |
45702-45703 |
NN |
denotes |
B |
T10999 |
45701-45702 |
HYPH |
denotes |
- |
T11000 |
45711-45715 |
VBD |
denotes |
were |
T11001 |
45727-45731 |
IN |
denotes |
from |
T11002 |
45732-45736 |
DT |
denotes |
each |
T11003 |
45737-45742 |
NN |
denotes |
mouse |
T11004 |
45743-45747 |
WDT |
denotes |
that |
T11005 |
45757-45763 |
VBN |
denotes |
tested |
T11006 |
45748-45751 |
VBD |
denotes |
had |
T11007 |
45752-45756 |
VBN |
denotes |
been |
T11008 |
45764-45766 |
IN |
denotes |
in |
T11009 |
45767-45770 |
DT |
denotes |
the |
T11010 |
45782-45793 |
NNS |
denotes |
experiments |
T11011 |
45771-45781 |
JJ |
denotes |
behavioral |
T11012 |
45793-45795 |
, |
denotes |
, |
T11013 |
45795-45798 |
CC |
denotes |
and |
T11014 |
45799-45805 |
NNS |
denotes |
levels |
T11015 |
45811-45821 |
VBN |
denotes |
correlated |
T11016 |
45806-45810 |
VBD |
denotes |
were |
T11017 |
45822-45826 |
IN |
denotes |
with |
T11018 |
45827-45831 |
NN |
denotes |
odor |
T11019 |
45842-45856 |
NN |
denotes |
discrimination |
T11020 |
45832-45840 |
NN |
denotes |
learning |
T11021 |
45840-45842 |
, |
denotes |
, |
T11022 |
45856-45858 |
, |
denotes |
, |
T11023 |
45858-45861 |
CC |
denotes |
and |
T11024 |
45862-45871 |
JJ |
denotes |
olfactory |
T11025 |
45872-45878 |
NN |
denotes |
memory |
T11026 |
45878-45879 |
. |
denotes |
. |
T11027 |
45879-46107 |
sentence |
denotes |
The significant direct correlation between residual GluR-B levels in hippocampus and cortical areas with olfactory memory suggested hippocampal and/or cortical neurons as putative mediators for odor memorization and/or storage. |
T11028 |
45880-45883 |
DT |
denotes |
The |
T11029 |
45903-45914 |
NN |
denotes |
correlation |
T11030 |
45884-45895 |
JJ |
denotes |
significant |
T11031 |
45896-45902 |
JJ |
denotes |
direct |
T11032 |
46002-46011 |
VBD |
denotes |
suggested |
T11033 |
45915-45922 |
IN |
denotes |
between |
T11034 |
45923-45931 |
JJ |
denotes |
residual |
T11035 |
45939-45945 |
NNS |
denotes |
levels |
T11036 |
45932-45936 |
NN |
denotes |
GluR |
T11037 |
45937-45938 |
NN |
denotes |
B |
T11038 |
45936-45937 |
HYPH |
denotes |
- |
T11039 |
45946-45948 |
IN |
denotes |
in |
T11040 |
45949-45960 |
NN |
denotes |
hippocampus |
T11041 |
45961-45964 |
CC |
denotes |
and |
T11042 |
45965-45973 |
JJ |
denotes |
cortical |
T11043 |
45974-45979 |
NNS |
denotes |
areas |
T11044 |
45980-45984 |
IN |
denotes |
with |
T11045 |
45985-45994 |
JJ |
denotes |
olfactory |
T11046 |
45995-46001 |
NN |
denotes |
memory |
T11047 |
46012-46023 |
JJ |
denotes |
hippocampal |
T11048 |
46040-46047 |
NNS |
denotes |
neurons |
T11049 |
46024-46027 |
CC |
denotes |
and |
T11050 |
46027-46028 |
HYPH |
denotes |
/ |
T11051 |
46028-46030 |
CC |
denotes |
or |
T11052 |
46031-46039 |
JJ |
denotes |
cortical |
T11053 |
46048-46050 |
IN |
denotes |
as |
T11054 |
46051-46059 |
JJ |
denotes |
putative |
T11055 |
46060-46069 |
NNS |
denotes |
mediators |
T11056 |
46070-46073 |
IN |
denotes |
for |
T11057 |
46074-46078 |
NN |
denotes |
odor |
T11058 |
46079-46091 |
NN |
denotes |
memorization |
T11059 |
46092-46095 |
CC |
denotes |
and |
T11060 |
46095-46096 |
HYPH |
denotes |
/ |
T11061 |
46096-46098 |
CC |
denotes |
or |
T11062 |
46099-46106 |
NN |
denotes |
storage |
T11063 |
46106-46107 |
. |
denotes |
. |
T11064 |
46107-46354 |
sentence |
denotes |
No measure of discrimination and learning, on the other hand, correlated with residual GluR-B levels; even the smallest reduction in GluR-B levels (about 20%–60%) was sufficient to establish and saturate enhanced odor discrimination capabilities. |
T11065 |
46108-46110 |
DT |
denotes |
No |
T11066 |
46111-46118 |
NN |
denotes |
measure |
T11067 |
46170-46180 |
VBD |
denotes |
correlated |
T11068 |
46119-46121 |
IN |
denotes |
of |
T11069 |
46122-46136 |
NN |
denotes |
discrimination |
T11070 |
46137-46140 |
CC |
denotes |
and |
T11071 |
46141-46149 |
NN |
denotes |
learning |
T11072 |
46149-46151 |
, |
denotes |
, |
T11073 |
46151-46153 |
IN |
denotes |
on |
T11074 |
46154-46157 |
DT |
denotes |
the |
T11075 |
46164-46168 |
NN |
denotes |
hand |
T11076 |
46158-46163 |
JJ |
denotes |
other |
T11077 |
46168-46170 |
, |
denotes |
, |
T11078 |
46271-46274 |
VBD |
denotes |
was |
T11079 |
46181-46185 |
IN |
denotes |
with |
T11080 |
46186-46194 |
JJ |
denotes |
residual |
T11081 |
46202-46208 |
NNS |
denotes |
levels |
T11082 |
46195-46199 |
NN |
denotes |
GluR |
T11083 |
46200-46201 |
NN |
denotes |
B |
T11084 |
46199-46200 |
HYPH |
denotes |
- |
T11085 |
46208-46209 |
: |
denotes |
; |
T11086 |
46210-46214 |
RB |
denotes |
even |
T11087 |
46228-46237 |
NN |
denotes |
reduction |
T11088 |
46215-46218 |
DT |
denotes |
the |
T11089 |
46219-46227 |
JJS |
denotes |
smallest |
T11090 |
46238-46240 |
IN |
denotes |
in |
T11091 |
46241-46245 |
NN |
denotes |
GluR |
T11092 |
46246-46247 |
NN |
denotes |
B |
T11093 |
46245-46246 |
HYPH |
denotes |
- |
T11094 |
46248-46254 |
NNS |
denotes |
levels |
T11095 |
46255-46256 |
-LRB- |
denotes |
( |
T11096 |
46264-46265 |
NN |
denotes |
% |
T11097 |
46256-46261 |
IN |
denotes |
about |
T11098 |
46262-46264 |
CD |
denotes |
20 |
T11099 |
46265-46266 |
SYM |
denotes |
– |
T11100 |
46268-46269 |
NN |
denotes |
% |
T11101 |
46266-46268 |
CD |
denotes |
60 |
T11102 |
46269-46270 |
-RRB- |
denotes |
) |
T11103 |
46275-46285 |
JJ |
denotes |
sufficient |
T11104 |
46286-46288 |
TO |
denotes |
to |
T11105 |
46289-46298 |
VB |
denotes |
establish |
T11106 |
46299-46302 |
CC |
denotes |
and |
T11107 |
46303-46311 |
VB |
denotes |
saturate |
T11108 |
46312-46320 |
VBN |
denotes |
enhanced |
T11109 |
46341-46353 |
NNS |
denotes |
capabilities |
T11110 |
46321-46325 |
NN |
denotes |
odor |
T11111 |
46326-46340 |
NN |
denotes |
discrimination |
T11112 |
46353-46354 |
. |
denotes |
. |
T11113 |
46354-46460 |
sentence |
denotes |
Together, this allows the conclusion that distinct mechanisms mediate discrimination/learning and memory. |
T11114 |
46355-46363 |
RB |
denotes |
Together |
T11115 |
46370-46376 |
VBZ |
denotes |
allows |
T11116 |
46363-46365 |
, |
denotes |
, |
T11117 |
46365-46369 |
DT |
denotes |
this |
T11118 |
46377-46380 |
DT |
denotes |
the |
T11119 |
46381-46391 |
NN |
denotes |
conclusion |
T11120 |
46392-46396 |
IN |
denotes |
that |
T11121 |
46417-46424 |
VBP |
denotes |
mediate |
T11122 |
46397-46405 |
JJ |
denotes |
distinct |
T11123 |
46406-46416 |
NNS |
denotes |
mechanisms |
T11124 |
46425-46439 |
NN |
denotes |
discrimination |
T11125 |
46440-46448 |
NN |
denotes |
learning |
T11126 |
46439-46440 |
HYPH |
denotes |
/ |
T11127 |
46449-46452 |
CC |
denotes |
and |
T11128 |
46453-46459 |
NN |
denotes |
memory |
T11129 |
46459-46460 |
. |
denotes |
. |
T11130 |
46460-46665 |
sentence |
denotes |
This is furthermore consistent with a prominent role of cortical areas or hippocampus in olfactory memory, although GluR-B levels in the olfactory bulb were also weakly correlated with memory performance. |
T11131 |
46461-46465 |
DT |
denotes |
This |
T11132 |
46466-46468 |
VBZ |
denotes |
is |
T11133 |
46469-46480 |
RB |
denotes |
furthermore |
T11134 |
46481-46491 |
JJ |
denotes |
consistent |
T11135 |
46492-46496 |
IN |
denotes |
with |
T11136 |
46497-46498 |
DT |
denotes |
a |
T11137 |
46509-46513 |
NN |
denotes |
role |
T11138 |
46499-46508 |
JJ |
denotes |
prominent |
T11139 |
46514-46516 |
IN |
denotes |
of |
T11140 |
46517-46525 |
JJ |
denotes |
cortical |
T11141 |
46526-46531 |
NNS |
denotes |
areas |
T11142 |
46532-46534 |
CC |
denotes |
or |
T11143 |
46535-46546 |
NN |
denotes |
hippocampus |
T11144 |
46547-46549 |
IN |
denotes |
in |
T11145 |
46550-46559 |
JJ |
denotes |
olfactory |
T11146 |
46560-46566 |
NN |
denotes |
memory |
T11147 |
46566-46568 |
, |
denotes |
, |
T11148 |
46568-46576 |
IN |
denotes |
although |
T11149 |
46630-46640 |
VBN |
denotes |
correlated |
T11150 |
46577-46581 |
NN |
denotes |
GluR |
T11151 |
46582-46583 |
NN |
denotes |
B |
T11152 |
46581-46582 |
HYPH |
denotes |
- |
T11153 |
46584-46590 |
NNS |
denotes |
levels |
T11154 |
46591-46593 |
IN |
denotes |
in |
T11155 |
46594-46597 |
DT |
denotes |
the |
T11156 |
46608-46612 |
NN |
denotes |
bulb |
T11157 |
46598-46607 |
JJ |
denotes |
olfactory |
T11158 |
46613-46617 |
VBD |
denotes |
were |
T11159 |
46618-46622 |
RB |
denotes |
also |
T11160 |
46623-46629 |
RB |
denotes |
weakly |
T11161 |
46641-46645 |
IN |
denotes |
with |
T11162 |
46646-46652 |
NN |
denotes |
memory |
T11163 |
46653-46664 |
NN |
denotes |
performance |
T11164 |
46664-46665 |
. |
denotes |
. |
T11165 |
46665-46968 |
sentence |
denotes |
Transgenic expression of GFPGluR-B in piriform cortex and hippocampus indeed rescued memory to an extent strikingly consistent with the transgenic protein levels (approximately 10% of wild-type GluR-B), confirming the reliability of the correlation analysis and the sensitivity of the behavioral assay. |
T11166 |
46666-46676 |
JJ |
denotes |
Transgenic |
T11167 |
46677-46687 |
NN |
denotes |
expression |
T11168 |
46743-46750 |
VBD |
denotes |
rescued |
T11169 |
46688-46690 |
IN |
denotes |
of |
T11170 |
46691-46698 |
NN |
denotes |
GFPGluR |
T11171 |
46699-46700 |
NN |
denotes |
B |
T11172 |
46698-46699 |
HYPH |
denotes |
- |
T11173 |
46701-46703 |
IN |
denotes |
in |
T11174 |
46704-46712 |
JJ |
denotes |
piriform |
T11175 |
46713-46719 |
NN |
denotes |
cortex |
T11176 |
46720-46723 |
CC |
denotes |
and |
T11177 |
46724-46735 |
NN |
denotes |
hippocampus |
T11178 |
46736-46742 |
RB |
denotes |
indeed |
T11179 |
46751-46757 |
NN |
denotes |
memory |
T11180 |
46758-46760 |
IN |
denotes |
to |
T11181 |
46761-46763 |
DT |
denotes |
an |
T11182 |
46764-46770 |
NN |
denotes |
extent |
T11183 |
46771-46781 |
RB |
denotes |
strikingly |
T11184 |
46782-46792 |
JJ |
denotes |
consistent |
T11185 |
46793-46797 |
IN |
denotes |
with |
T11186 |
46798-46801 |
DT |
denotes |
the |
T11187 |
46821-46827 |
NNS |
denotes |
levels |
T11188 |
46802-46812 |
JJ |
denotes |
transgenic |
T11189 |
46813-46820 |
NN |
denotes |
protein |
T11190 |
46828-46829 |
-LRB- |
denotes |
( |
T11191 |
46845-46846 |
NN |
denotes |
% |
T11192 |
46829-46842 |
RB |
denotes |
approximately |
T11193 |
46843-46845 |
CD |
denotes |
10 |
T11194 |
46847-46849 |
IN |
denotes |
of |
T11195 |
46850-46854 |
JJ |
denotes |
wild |
T11196 |
46855-46859 |
NN |
denotes |
type |
T11197 |
46854-46855 |
HYPH |
denotes |
- |
T11198 |
46865-46866 |
NN |
denotes |
B |
T11199 |
46860-46864 |
NN |
denotes |
GluR |
T11200 |
46864-46865 |
HYPH |
denotes |
- |
T11201 |
46866-46867 |
-RRB- |
denotes |
) |
T11202 |
46867-46869 |
, |
denotes |
, |
T11203 |
46869-46879 |
VBG |
denotes |
confirming |
T11204 |
46880-46883 |
DT |
denotes |
the |
T11205 |
46884-46895 |
NN |
denotes |
reliability |
T11206 |
46896-46898 |
IN |
denotes |
of |
T11207 |
46899-46902 |
DT |
denotes |
the |
T11208 |
46915-46923 |
NN |
denotes |
analysis |
T11209 |
46903-46914 |
NN |
denotes |
correlation |
T11210 |
46924-46927 |
CC |
denotes |
and |
T11211 |
46928-46931 |
DT |
denotes |
the |
T11212 |
46932-46943 |
NN |
denotes |
sensitivity |
T11213 |
46944-46946 |
IN |
denotes |
of |
T11214 |
46947-46950 |
DT |
denotes |
the |
T11215 |
46962-46967 |
NN |
denotes |
assay |
T11216 |
46951-46961 |
JJ |
denotes |
behavioral |
T11217 |
46967-46968 |
. |
denotes |
. |
T11218 |
46968-47156 |
sentence |
denotes |
In general, the hippocampus is thought to be involved in only those olfactory memory tasks that involve temporal sequence analysis or require other higher cognitive features [2,13,72–74]. |
T11219 |
46969-46971 |
IN |
denotes |
In |
T11220 |
47000-47007 |
VBN |
denotes |
thought |
T11221 |
46972-46979 |
JJ |
denotes |
general |
T11222 |
46979-46981 |
, |
denotes |
, |
T11223 |
46981-46984 |
DT |
denotes |
the |
T11224 |
46985-46996 |
NN |
denotes |
hippocampus |
T11225 |
46997-46999 |
VBZ |
denotes |
is |
T11226 |
47008-47010 |
TO |
denotes |
to |
T11227 |
47014-47022 |
VBN |
denotes |
involved |
T11228 |
47011-47013 |
VB |
denotes |
be |
T11229 |
47023-47025 |
IN |
denotes |
in |
T11230 |
47026-47030 |
RB |
denotes |
only |
T11231 |
47054-47059 |
NNS |
denotes |
tasks |
T11232 |
47031-47036 |
DT |
denotes |
those |
T11233 |
47037-47046 |
JJ |
denotes |
olfactory |
T11234 |
47047-47053 |
NN |
denotes |
memory |
T11235 |
47060-47064 |
WDT |
denotes |
that |
T11236 |
47065-47072 |
VBP |
denotes |
involve |
T11237 |
47073-47081 |
JJ |
denotes |
temporal |
T11238 |
47082-47090 |
NN |
denotes |
sequence |
T11239 |
47091-47099 |
NN |
denotes |
analysis |
T11240 |
47100-47102 |
CC |
denotes |
or |
T11241 |
47103-47110 |
VBP |
denotes |
require |
T11242 |
47111-47116 |
JJ |
denotes |
other |
T11243 |
47134-47142 |
NNS |
denotes |
features |
T11244 |
47117-47123 |
JJR |
denotes |
higher |
T11245 |
47124-47133 |
JJ |
denotes |
cognitive |
T11246 |
47143-47144 |
-LRB- |
denotes |
[ |
T11247 |
47144-47145 |
CD |
denotes |
2 |
T11248 |
47145-47146 |
, |
denotes |
, |
T11249 |
47146-47148 |
CD |
denotes |
13 |
T11250 |
47148-47149 |
, |
denotes |
, |
T11251 |
47149-47151 |
CD |
denotes |
72 |
T11252 |
47151-47152 |
SYM |
denotes |
– |
T11253 |
47152-47154 |
CD |
denotes |
74 |
T11254 |
47154-47155 |
-RRB- |
denotes |
] |
T11255 |
47155-47156 |
. |
denotes |
. |
T11256 |
47156-47362 |
sentence |
denotes |
In particular, extensive lesions to the hippocampal formation in rats do not interfere with long-term olfactory memory in go/no-go successive olfactory discrimination tasks [72], such as the one described. |
T11257 |
47157-47159 |
IN |
denotes |
In |
T11258 |
47234-47243 |
VB |
denotes |
interfere |
T11259 |
47160-47170 |
JJ |
denotes |
particular |
T11260 |
47170-47172 |
, |
denotes |
, |
T11261 |
47172-47181 |
JJ |
denotes |
extensive |
T11262 |
47182-47189 |
NNS |
denotes |
lesions |
T11263 |
47190-47192 |
IN |
denotes |
to |
T11264 |
47193-47196 |
DT |
denotes |
the |
T11265 |
47209-47218 |
NN |
denotes |
formation |
T11266 |
47197-47208 |
JJ |
denotes |
hippocampal |
T11267 |
47219-47221 |
IN |
denotes |
in |
T11268 |
47222-47226 |
NNS |
denotes |
rats |
T11269 |
47227-47229 |
VBP |
denotes |
do |
T11270 |
47230-47233 |
RB |
denotes |
not |
T11271 |
47244-47248 |
IN |
denotes |
with |
T11272 |
47249-47253 |
JJ |
denotes |
long |
T11273 |
47254-47258 |
NN |
denotes |
term |
T11274 |
47253-47254 |
HYPH |
denotes |
- |
T11275 |
47269-47275 |
NN |
denotes |
memory |
T11276 |
47259-47268 |
JJ |
denotes |
olfactory |
T11277 |
47276-47278 |
IN |
denotes |
in |
T11278 |
47279-47281 |
NN |
denotes |
go |
T11279 |
47324-47329 |
NNS |
denotes |
tasks |
T11280 |
47281-47282 |
HYPH |
denotes |
/ |
T11281 |
47282-47284 |
DT |
denotes |
no |
T11282 |
47285-47287 |
NN |
denotes |
go |
T11283 |
47284-47285 |
HYPH |
denotes |
- |
T11284 |
47288-47298 |
JJ |
denotes |
successive |
T11285 |
47299-47308 |
JJ |
denotes |
olfactory |
T11286 |
47309-47323 |
NN |
denotes |
discrimination |
T11287 |
47330-47331 |
-LRB- |
denotes |
[ |
T11288 |
47331-47333 |
CD |
denotes |
72 |
T11289 |
47333-47334 |
-RRB- |
denotes |
] |
T11290 |
47334-47336 |
, |
denotes |
, |
T11291 |
47336-47340 |
JJ |
denotes |
such |
T11292 |
47341-47343 |
IN |
denotes |
as |
T11293 |
47344-47347 |
DT |
denotes |
the |
T11294 |
47348-47351 |
CD |
denotes |
one |
T11295 |
47352-47361 |
VBN |
denotes |
described |
T11296 |
47361-47362 |
. |
denotes |
. |
T11297 |
47362-47637 |
sentence |
denotes |
This leaves piriform cortex as the most prominent candidate for the locus of the olfactory memory deficit described, consistent with the prevalent view of piriform cortex as an associational memory structure [75] and learning-associated changes in piriform cortex [7,20–23]. |
T11298 |
47363-47367 |
DT |
denotes |
This |
T11299 |
47368-47374 |
VBZ |
denotes |
leaves |
T11300 |
47375-47383 |
JJ |
denotes |
piriform |
T11301 |
47384-47390 |
NN |
denotes |
cortex |
T11302 |
47391-47393 |
IN |
denotes |
as |
T11303 |
47394-47397 |
DT |
denotes |
the |
T11304 |
47413-47422 |
NN |
denotes |
candidate |
T11305 |
47398-47402 |
RBS |
denotes |
most |
T11306 |
47403-47412 |
JJ |
denotes |
prominent |
T11307 |
47423-47426 |
IN |
denotes |
for |
T11308 |
47427-47430 |
DT |
denotes |
the |
T11309 |
47431-47436 |
NN |
denotes |
locus |
T11310 |
47437-47439 |
IN |
denotes |
of |
T11311 |
47440-47443 |
DT |
denotes |
the |
T11312 |
47461-47468 |
NN |
denotes |
deficit |
T11313 |
47444-47453 |
JJ |
denotes |
olfactory |
T11314 |
47454-47460 |
NN |
denotes |
memory |
T11315 |
47469-47478 |
VBN |
denotes |
described |
T11316 |
47478-47480 |
, |
denotes |
, |
T11317 |
47480-47490 |
JJ |
denotes |
consistent |
T11318 |
47491-47495 |
IN |
denotes |
with |
T11319 |
47496-47499 |
DT |
denotes |
the |
T11320 |
47510-47514 |
NN |
denotes |
view |
T11321 |
47500-47509 |
JJ |
denotes |
prevalent |
T11322 |
47515-47517 |
IN |
denotes |
of |
T11323 |
47518-47526 |
JJ |
denotes |
piriform |
T11324 |
47527-47533 |
NN |
denotes |
cortex |
T11325 |
47534-47536 |
IN |
denotes |
as |
T11326 |
47537-47539 |
DT |
denotes |
an |
T11327 |
47561-47570 |
NN |
denotes |
structure |
T11328 |
47540-47553 |
JJ |
denotes |
associational |
T11329 |
47554-47560 |
NN |
denotes |
memory |
T11330 |
47571-47572 |
-LRB- |
denotes |
[ |
T11331 |
47572-47574 |
CD |
denotes |
75 |
T11332 |
47574-47575 |
-RRB- |
denotes |
] |
T11333 |
47576-47579 |
CC |
denotes |
and |
T11334 |
47580-47588 |
NN |
denotes |
learning |
T11335 |
47589-47599 |
VBN |
denotes |
associated |
T11336 |
47588-47589 |
HYPH |
denotes |
- |
T11337 |
47600-47607 |
NNS |
denotes |
changes |
T11338 |
47608-47610 |
IN |
denotes |
in |
T11339 |
47611-47619 |
JJ |
denotes |
piriform |
T11340 |
47620-47626 |
NN |
denotes |
cortex |
T11341 |
47627-47628 |
-LRB- |
denotes |
[ |
T11342 |
47628-47629 |
CD |
denotes |
7 |
T11343 |
47629-47630 |
, |
denotes |
, |
T11344 |
47630-47632 |
CD |
denotes |
20 |
T11345 |
47632-47633 |
SYM |
denotes |
– |
T11346 |
47633-47635 |
CD |
denotes |
23 |
T11347 |
47635-47636 |
-RRB- |
denotes |
] |
T11348 |
47636-47637 |
. |
denotes |
. |
T11632 |
47639-47648 |
JJ |
denotes |
Potential |
T11633 |
47649-47659 |
NNS |
denotes |
Mechanisms |
T11634 |
47660-47662 |
IN |
denotes |
of |
T11635 |
47663-47671 |
JJ |
denotes |
Specific |
T11636 |
47689-47699 |
NN |
denotes |
Impairment |
T11637 |
47672-47681 |
JJ |
denotes |
Olfactory |
T11638 |
47682-47688 |
NN |
denotes |
Memory |
T11639 |
47699-47815 |
sentence |
denotes |
What could be the cellular basis of the long-term memory deficit brought about by lack of GluR-B-containing AMPARs? |
T11640 |
47700-47704 |
WP |
denotes |
What |
T11641 |
47711-47713 |
VB |
denotes |
be |
T11642 |
47705-47710 |
MD |
denotes |
could |
T11643 |
47714-47717 |
DT |
denotes |
the |
T11644 |
47727-47732 |
NN |
denotes |
basis |
T11645 |
47718-47726 |
JJ |
denotes |
cellular |
T11646 |
47733-47735 |
IN |
denotes |
of |
T11647 |
47736-47739 |
DT |
denotes |
the |
T11648 |
47757-47764 |
NN |
denotes |
deficit |
T11649 |
47740-47744 |
JJ |
denotes |
long |
T11650 |
47745-47749 |
NN |
denotes |
term |
T11651 |
47744-47745 |
HYPH |
denotes |
- |
T11652 |
47750-47756 |
NN |
denotes |
memory |
T11653 |
47765-47772 |
VBN |
denotes |
brought |
T11654 |
47773-47778 |
RP |
denotes |
about |
T11655 |
47779-47781 |
IN |
denotes |
by |
T11656 |
47782-47786 |
NN |
denotes |
lack |
T11657 |
47787-47789 |
IN |
denotes |
of |
T11658 |
47790-47794 |
NN |
denotes |
GluR |
T11659 |
47795-47796 |
NN |
denotes |
B |
T11660 |
47794-47795 |
HYPH |
denotes |
- |
T11661 |
47797-47807 |
VBG |
denotes |
containing |
T11662 |
47796-47797 |
HYPH |
denotes |
- |
T11663 |
47808-47814 |
NNS |
denotes |
AMPARs |
T11664 |
47814-47815 |
. |
denotes |
? |
T11665 |
47815-47934 |
sentence |
denotes |
For complete GluR-B knockouts, increased long-term plasticity (LTP) was reported in hippocampal field recordings [51]. |
T11666 |
47816-47819 |
IN |
denotes |
For |
T11667 |
47888-47896 |
VBN |
denotes |
reported |
T11668 |
47820-47828 |
JJ |
denotes |
complete |
T11669 |
47836-47845 |
NNS |
denotes |
knockouts |
T11670 |
47829-47833 |
NN |
denotes |
GluR |
T11671 |
47834-47835 |
NN |
denotes |
B |
T11672 |
47833-47834 |
HYPH |
denotes |
- |
T11673 |
47845-47847 |
, |
denotes |
, |
T11674 |
47847-47856 |
VBN |
denotes |
increased |
T11675 |
47867-47877 |
NN |
denotes |
plasticity |
T11676 |
47857-47861 |
JJ |
denotes |
long |
T11677 |
47862-47866 |
NN |
denotes |
term |
T11678 |
47861-47862 |
HYPH |
denotes |
- |
T11679 |
47878-47879 |
-LRB- |
denotes |
( |
T11680 |
47879-47882 |
NN |
denotes |
LTP |
T11681 |
47882-47883 |
-RRB- |
denotes |
) |
T11682 |
47884-47887 |
VBD |
denotes |
was |
T11683 |
47897-47899 |
IN |
denotes |
in |
T11684 |
47900-47911 |
JJ |
denotes |
hippocampal |
T11685 |
47918-47928 |
NNS |
denotes |
recordings |
T11686 |
47912-47917 |
NN |
denotes |
field |
T11687 |
47929-47930 |
-LRB- |
denotes |
[ |
T11688 |
47930-47932 |
CD |
denotes |
51 |
T11689 |
47932-47933 |
-RRB- |
denotes |
] |
T11690 |
47933-47934 |
. |
denotes |
. |
T11691 |
47934-48113 |
sentence |
denotes |
In addition, in hippocampal and amygdala pathways lacking GluR-B, an AMPAR-dependent, N-methyl-D-aspartate (NMDA) receptor-independent form of LTP can be readily induced [51,52]. |
T11692 |
47935-47937 |
IN |
denotes |
In |
T11693 |
48097-48104 |
VBN |
denotes |
induced |
T11694 |
47938-47946 |
NN |
denotes |
addition |
T11695 |
47946-47948 |
, |
denotes |
, |
T11696 |
47948-47950 |
IN |
denotes |
in |
T11697 |
47951-47962 |
JJ |
denotes |
hippocampal |
T11698 |
47976-47984 |
NNS |
denotes |
pathways |
T11699 |
47963-47966 |
CC |
denotes |
and |
T11700 |
47967-47975 |
NN |
denotes |
amygdala |
T11701 |
47985-47992 |
VBG |
denotes |
lacking |
T11702 |
47993-47997 |
NN |
denotes |
GluR |
T11703 |
47998-47999 |
NN |
denotes |
B |
T11704 |
47997-47998 |
HYPH |
denotes |
- |
T11705 |
47999-48001 |
, |
denotes |
, |
T11706 |
48001-48003 |
DT |
denotes |
an |
T11707 |
48070-48074 |
NN |
denotes |
form |
T11708 |
48004-48009 |
NN |
denotes |
AMPAR |
T11709 |
48010-48019 |
JJ |
denotes |
dependent |
T11710 |
48009-48010 |
HYPH |
denotes |
- |
T11711 |
48019-48021 |
, |
denotes |
, |
T11712 |
48021-48022 |
NN |
denotes |
N |
T11713 |
48032-48041 |
NN |
denotes |
aspartate |
T11714 |
48022-48023 |
HYPH |
denotes |
- |
T11715 |
48023-48029 |
NN |
denotes |
methyl |
T11716 |
48029-48030 |
HYPH |
denotes |
- |
T11717 |
48030-48031 |
NN |
denotes |
D |
T11718 |
48031-48032 |
HYPH |
denotes |
- |
T11719 |
48042-48043 |
-LRB- |
denotes |
( |
T11720 |
48043-48047 |
NN |
denotes |
NMDA |
T11721 |
48047-48048 |
-RRB- |
denotes |
) |
T11722 |
48049-48057 |
NN |
denotes |
receptor |
T11723 |
48058-48069 |
JJ |
denotes |
independent |
T11724 |
48057-48058 |
HYPH |
denotes |
- |
T11725 |
48075-48077 |
IN |
denotes |
of |
T11726 |
48078-48081 |
NN |
denotes |
LTP |
T11727 |
48082-48085 |
MD |
denotes |
can |
T11728 |
48086-48088 |
VB |
denotes |
be |
T11729 |
48089-48096 |
RB |
denotes |
readily |
T11730 |
48105-48106 |
-LRB- |
denotes |
[ |
T11731 |
48109-48111 |
CD |
denotes |
52 |
T11732 |
48106-48108 |
CD |
denotes |
51 |
T11733 |
48108-48109 |
, |
denotes |
, |
T11734 |
48111-48112 |
-RRB- |
denotes |
] |
T11735 |
48112-48113 |
. |
denotes |
. |
T11736 |
48113-48248 |
sentence |
denotes |
Mechanistically, this is likely to be due to Ca2+ influx through GluR-B-less AMPA channels leading to non-hebbian forms of plasticity. |
T11737 |
48114-48129 |
RB |
denotes |
Mechanistically |
T11738 |
48136-48138 |
VBZ |
denotes |
is |
T11739 |
48129-48131 |
, |
denotes |
, |
T11740 |
48131-48135 |
DT |
denotes |
this |
T11741 |
48139-48145 |
JJ |
denotes |
likely |
T11742 |
48146-48148 |
TO |
denotes |
to |
T11743 |
48149-48151 |
VB |
denotes |
be |
T11744 |
48152-48155 |
IN |
denotes |
due |
T11745 |
48156-48158 |
IN |
denotes |
to |
T11746 |
48159-48162 |
NN |
denotes |
Ca2 |
T11747 |
48164-48170 |
NN |
denotes |
influx |
T11748 |
48162-48163 |
SYM |
denotes |
+ |
T11749 |
48171-48178 |
IN |
denotes |
through |
T11750 |
48179-48183 |
NN |
denotes |
GluR |
T11751 |
48184-48185 |
NN |
denotes |
B |
T11752 |
48183-48184 |
HYPH |
denotes |
- |
T11753 |
48186-48190 |
JJ |
denotes |
less |
T11754 |
48185-48186 |
HYPH |
denotes |
- |
T11755 |
48196-48204 |
NNS |
denotes |
channels |
T11756 |
48191-48195 |
NN |
denotes |
AMPA |
T11757 |
48205-48212 |
VBG |
denotes |
leading |
T11758 |
48213-48215 |
IN |
denotes |
to |
T11759 |
48216-48227 |
JJ |
denotes |
non-hebbian |
T11760 |
48228-48233 |
NNS |
denotes |
forms |
T11761 |
48234-48236 |
IN |
denotes |
of |
T11762 |
48237-48247 |
NN |
denotes |
plasticity |
T11763 |
48247-48248 |
. |
denotes |
. |
T11764 |
48248-48475 |
sentence |
denotes |
However, hebbian dependence on simultaneous pre- and postsynaptic activity is often a critical feature for memory storage (reviewed in e.g. [76]); hence, a non-hebbian form of plasticity should result in impaired memorization. |
T11765 |
48249-48256 |
RB |
denotes |
However |
T11766 |
48324-48326 |
VBZ |
denotes |
is |
T11767 |
48256-48258 |
, |
denotes |
, |
T11768 |
48258-48265 |
JJ |
denotes |
hebbian |
T11769 |
48266-48276 |
NN |
denotes |
dependence |
T11770 |
48277-48279 |
IN |
denotes |
on |
T11771 |
48280-48292 |
JJ |
denotes |
simultaneous |
T11772 |
48315-48323 |
NN |
denotes |
activity |
T11773 |
48293-48296 |
AFX |
denotes |
pre |
T11774 |
48302-48314 |
JJ |
denotes |
postsynaptic |
T11775 |
48296-48297 |
HYPH |
denotes |
- |
T11776 |
48298-48301 |
CC |
denotes |
and |
T11777 |
48443-48449 |
VB |
denotes |
result |
T11778 |
48327-48332 |
RB |
denotes |
often |
T11779 |
48333-48334 |
DT |
denotes |
a |
T11780 |
48344-48351 |
NN |
denotes |
feature |
T11781 |
48335-48343 |
JJ |
denotes |
critical |
T11782 |
48352-48355 |
IN |
denotes |
for |
T11783 |
48356-48362 |
NN |
denotes |
memory |
T11784 |
48363-48370 |
NN |
denotes |
storage |
T11785 |
48371-48372 |
-LRB- |
denotes |
( |
T11786 |
48372-48380 |
VBN |
denotes |
reviewed |
T11787 |
48381-48383 |
IN |
denotes |
in |
T11788 |
48384-48388 |
FW |
denotes |
e.g. |
T11789 |
48390-48392 |
CD |
denotes |
76 |
T11790 |
48389-48390 |
-LRB- |
denotes |
[ |
T11791 |
48392-48393 |
-RRB- |
denotes |
] |
T11792 |
48393-48394 |
-RRB- |
denotes |
) |
T11793 |
48394-48395 |
: |
denotes |
; |
T11794 |
48396-48401 |
RB |
denotes |
hence |
T11795 |
48401-48403 |
, |
denotes |
, |
T11796 |
48403-48404 |
DT |
denotes |
a |
T11797 |
48417-48421 |
NN |
denotes |
form |
T11798 |
48405-48416 |
JJ |
denotes |
non-hebbian |
T11799 |
48422-48424 |
IN |
denotes |
of |
T11800 |
48425-48435 |
NN |
denotes |
plasticity |
T11801 |
48436-48442 |
MD |
denotes |
should |
T11802 |
48450-48452 |
IN |
denotes |
in |
T11803 |
48453-48461 |
VBN |
denotes |
impaired |
T11804 |
48462-48474 |
NN |
denotes |
memorization |
T11805 |
48474-48475 |
. |
denotes |
. |
T11806 |
48475-48788 |
sentence |
denotes |
Surprisingly, in GluR-BΔFB mice no LTP changes could be observed in field measurements in the hippocampus, nor could NMDA-independent LTP be induced in hippocampal synapses between Schaffer collaterals and CA1 pyramidal cells in presence of the NMDA antagonist APV (K. Jensen, O. Hvalby, personal communication). |
T11807 |
48476-48488 |
RB |
denotes |
Surprisingly |
T11808 |
48532-48540 |
VBN |
denotes |
observed |
T11809 |
48488-48490 |
, |
denotes |
, |
T11810 |
48490-48492 |
IN |
denotes |
in |
T11811 |
48493-48497 |
NN |
denotes |
GluR |
T11812 |
48498-48502 |
NN |
denotes |
BΔFB |
T11813 |
48497-48498 |
HYPH |
denotes |
- |
T11814 |
48503-48507 |
NNS |
denotes |
mice |
T11815 |
48508-48510 |
DT |
denotes |
no |
T11816 |
48515-48522 |
NNS |
denotes |
changes |
T11817 |
48511-48514 |
NN |
denotes |
LTP |
T11818 |
48523-48528 |
MD |
denotes |
could |
T11819 |
48529-48531 |
VB |
denotes |
be |
T11820 |
48541-48543 |
IN |
denotes |
in |
T11821 |
48544-48549 |
NN |
denotes |
field |
T11822 |
48550-48562 |
NNS |
denotes |
measurements |
T11823 |
48563-48565 |
IN |
denotes |
in |
T11824 |
48566-48569 |
DT |
denotes |
the |
T11825 |
48570-48581 |
NN |
denotes |
hippocampus |
T11826 |
48581-48583 |
, |
denotes |
, |
T11827 |
48583-48586 |
CC |
denotes |
nor |
T11828 |
48587-48592 |
MD |
denotes |
could |
T11829 |
48617-48624 |
VBN |
denotes |
induced |
T11830 |
48593-48597 |
NN |
denotes |
NMDA |
T11831 |
48598-48609 |
JJ |
denotes |
independent |
T11832 |
48597-48598 |
HYPH |
denotes |
- |
T11833 |
48610-48613 |
NN |
denotes |
LTP |
T11834 |
48614-48616 |
VB |
denotes |
be |
T11835 |
48625-48627 |
IN |
denotes |
in |
T11836 |
48628-48639 |
JJ |
denotes |
hippocampal |
T11837 |
48640-48648 |
NNS |
denotes |
synapses |
T11838 |
48649-48656 |
IN |
denotes |
between |
T11839 |
48657-48665 |
NNP |
denotes |
Schaffer |
T11840 |
48666-48677 |
NNS |
denotes |
collaterals |
T11841 |
48678-48681 |
CC |
denotes |
and |
T11842 |
48682-48685 |
NN |
denotes |
CA1 |
T11843 |
48696-48701 |
NNS |
denotes |
cells |
T11844 |
48686-48695 |
JJ |
denotes |
pyramidal |
T11845 |
48702-48704 |
IN |
denotes |
in |
T11846 |
48705-48713 |
NN |
denotes |
presence |
T11847 |
48714-48716 |
IN |
denotes |
of |
T11848 |
48717-48720 |
DT |
denotes |
the |
T11849 |
48726-48736 |
NN |
denotes |
antagonist |
T11850 |
48721-48725 |
NN |
denotes |
NMDA |
T11851 |
48737-48740 |
NN |
denotes |
APV |
T11852 |
48741-48742 |
-LRB- |
denotes |
( |
T11853 |
48742-48744 |
NNP |
denotes |
K. |
T11854 |
48745-48751 |
NNP |
denotes |
Jensen |
T11855 |
48751-48753 |
, |
denotes |
, |
T11856 |
48753-48755 |
NNP |
denotes |
O. |
T11857 |
48756-48762 |
NNP |
denotes |
Hvalby |
T11858 |
48762-48764 |
, |
denotes |
, |
T11859 |
48764-48772 |
JJ |
denotes |
personal |
T11860 |
48773-48786 |
NN |
denotes |
communication |
T11861 |
48786-48787 |
-RRB- |
denotes |
) |
T11862 |
48787-48788 |
. |
denotes |
. |
T11863 |
48788-49074 |
sentence |
denotes |
However, in other brain areas that are potentially important for the processing of olfactory information, such as piriform cortex or olfactory bulb, LTP measurements have not yet been performed; synapses of these pathways may be regulated differently than hippocampal CA3/CA1 synapses. |
T11864 |
48789-48796 |
RB |
denotes |
However |
T11865 |
48973-48982 |
VBN |
denotes |
performed |
T11866 |
48796-48798 |
, |
denotes |
, |
T11867 |
48798-48800 |
IN |
denotes |
in |
T11868 |
48801-48806 |
JJ |
denotes |
other |
T11869 |
48813-48818 |
NNS |
denotes |
areas |
T11870 |
48807-48812 |
NN |
denotes |
brain |
T11871 |
48819-48823 |
WDT |
denotes |
that |
T11872 |
48824-48827 |
VBP |
denotes |
are |
T11873 |
48828-48839 |
RB |
denotes |
potentially |
T11874 |
48840-48849 |
JJ |
denotes |
important |
T11875 |
48850-48853 |
IN |
denotes |
for |
T11876 |
48854-48857 |
DT |
denotes |
the |
T11877 |
48858-48868 |
NN |
denotes |
processing |
T11878 |
48869-48871 |
IN |
denotes |
of |
T11879 |
48872-48881 |
JJ |
denotes |
olfactory |
T11880 |
48882-48893 |
NN |
denotes |
information |
T11881 |
48893-48895 |
, |
denotes |
, |
T11882 |
48895-48899 |
JJ |
denotes |
such |
T11883 |
48900-48902 |
IN |
denotes |
as |
T11884 |
48903-48911 |
JJ |
denotes |
piriform |
T11885 |
48912-48918 |
NN |
denotes |
cortex |
T11886 |
48919-48921 |
CC |
denotes |
or |
T11887 |
48922-48931 |
JJ |
denotes |
olfactory |
T11888 |
48932-48936 |
NN |
denotes |
bulb |
T11889 |
48936-48938 |
, |
denotes |
, |
T11890 |
48938-48941 |
NN |
denotes |
LTP |
T11891 |
48942-48954 |
NNS |
denotes |
measurements |
T11892 |
48955-48959 |
VBP |
denotes |
have |
T11893 |
48960-48963 |
RB |
denotes |
not |
T11894 |
48964-48967 |
RB |
denotes |
yet |
T11895 |
48968-48972 |
VBN |
denotes |
been |
T11896 |
49018-49027 |
VBN |
denotes |
regulated |
T11897 |
48982-48983 |
: |
denotes |
; |
T11898 |
48984-48992 |
NNS |
denotes |
synapses |
T11899 |
48993-48995 |
IN |
denotes |
of |
T11900 |
48996-49001 |
DT |
denotes |
these |
T11901 |
49002-49010 |
NNS |
denotes |
pathways |
T11902 |
49011-49014 |
MD |
denotes |
may |
T11903 |
49015-49017 |
VB |
denotes |
be |
T11904 |
49028-49039 |
RB |
denotes |
differently |
T11905 |
49040-49044 |
IN |
denotes |
than |
T11906 |
49045-49056 |
JJ |
denotes |
hippocampal |
T11907 |
49065-49073 |
NNS |
denotes |
synapses |
T11908 |
49057-49060 |
NN |
denotes |
CA3 |
T11909 |
49061-49064 |
NN |
denotes |
CA1 |
T11910 |
49060-49061 |
HYPH |
denotes |
/ |
T11911 |
49073-49074 |
. |
denotes |
. |
T11912 |
49074-49243 |
sentence |
denotes |
Additionally, by changing the Ca2+ permeability of AMPARs, Ca2+ signaling via AMPA and colocalized NMDA channels might be disturbed, thereby impairing memory formation. |
T11913 |
49075-49087 |
RB |
denotes |
Additionally |
T11914 |
49197-49206 |
VBN |
denotes |
disturbed |
T11915 |
49087-49089 |
, |
denotes |
, |
T11916 |
49089-49091 |
IN |
denotes |
by |
T11917 |
49092-49100 |
VBG |
denotes |
changing |
T11918 |
49101-49104 |
DT |
denotes |
the |
T11919 |
49110-49122 |
NN |
denotes |
permeability |
T11920 |
49105-49108 |
NN |
denotes |
Ca2 |
T11921 |
49108-49109 |
SYM |
denotes |
+ |
T11922 |
49123-49125 |
IN |
denotes |
of |
T11923 |
49126-49132 |
NNS |
denotes |
AMPARs |
T11924 |
49132-49134 |
, |
denotes |
, |
T11925 |
49134-49137 |
NN |
denotes |
Ca2 |
T11926 |
49139-49148 |
NN |
denotes |
signaling |
T11927 |
49137-49138 |
SYM |
denotes |
+ |
T11928 |
49149-49152 |
IN |
denotes |
via |
T11929 |
49153-49157 |
NN |
denotes |
AMPA |
T11930 |
49179-49187 |
NNS |
denotes |
channels |
T11931 |
49158-49161 |
CC |
denotes |
and |
T11932 |
49162-49173 |
VBN |
denotes |
colocalized |
T11933 |
49174-49178 |
NN |
denotes |
NMDA |
T11934 |
49188-49193 |
MD |
denotes |
might |
T11935 |
49194-49196 |
VB |
denotes |
be |
T11936 |
49206-49208 |
, |
denotes |
, |
T11937 |
49208-49215 |
RB |
denotes |
thereby |
T11938 |
49216-49225 |
VBG |
denotes |
impairing |
T11939 |
49226-49232 |
NN |
denotes |
memory |
T11940 |
49233-49242 |
NN |
denotes |
formation |
T11941 |
49242-49243 |
. |
denotes |
. |
T11942 |
49243-49359 |
sentence |
denotes |
Other forms of plasticity [77,78] induced by Ca2+-permeable AMPARs might play a prevalent role in olfactory memory. |
T11943 |
49244-49249 |
JJ |
denotes |
Other |
T11944 |
49250-49255 |
NNS |
denotes |
forms |
T11945 |
49317-49321 |
VB |
denotes |
play |
T11946 |
49256-49258 |
IN |
denotes |
of |
T11947 |
49259-49269 |
NN |
denotes |
plasticity |
T11948 |
49270-49271 |
-LRB- |
denotes |
[ |
T11949 |
49274-49276 |
CD |
denotes |
78 |
T11950 |
49271-49273 |
CD |
denotes |
77 |
T11951 |
49273-49274 |
, |
denotes |
, |
T11952 |
49276-49277 |
-RRB- |
denotes |
] |
T11953 |
49278-49285 |
VBN |
denotes |
induced |
T11954 |
49286-49288 |
IN |
denotes |
by |
T11955 |
49289-49292 |
NN |
denotes |
Ca2 |
T11956 |
49294-49303 |
JJ |
denotes |
permeable |
T11957 |
49292-49293 |
SYM |
denotes |
+ |
T11958 |
49293-49294 |
HYPH |
denotes |
- |
T11959 |
49304-49310 |
NNS |
denotes |
AMPARs |
T11960 |
49311-49316 |
MD |
denotes |
might |
T11961 |
49322-49323 |
DT |
denotes |
a |
T11962 |
49334-49338 |
NN |
denotes |
role |
T11963 |
49324-49333 |
JJ |
denotes |
prevalent |
T11964 |
49339-49341 |
IN |
denotes |
in |
T11965 |
49342-49351 |
JJ |
denotes |
olfactory |
T11966 |
49352-49358 |
NN |
denotes |
memory |
T11967 |
49358-49359 |
. |
denotes |
. |
T11968 |
49359-49537 |
sentence |
denotes |
Alternatively, long-term stabilization might involve GluR-B phosphorylation similar to cerebellar long-term depression [79] and thus be selectively impaired by GluR-B depletion. |
T11969 |
49360-49373 |
RB |
denotes |
Alternatively |
T11970 |
49405-49412 |
VB |
denotes |
involve |
T11971 |
49373-49375 |
, |
denotes |
, |
T11972 |
49375-49379 |
JJ |
denotes |
long |
T11973 |
49380-49384 |
NN |
denotes |
term |
T11974 |
49379-49380 |
HYPH |
denotes |
- |
T11975 |
49385-49398 |
NN |
denotes |
stabilization |
T11976 |
49399-49404 |
MD |
denotes |
might |
T11977 |
49413-49417 |
NN |
denotes |
GluR |
T11978 |
49418-49419 |
NN |
denotes |
B |
T11979 |
49417-49418 |
HYPH |
denotes |
- |
T11980 |
49420-49435 |
NN |
denotes |
phosphorylation |
T11981 |
49436-49443 |
JJ |
denotes |
similar |
T11982 |
49444-49446 |
IN |
denotes |
to |
T11983 |
49447-49457 |
JJ |
denotes |
cerebellar |
T11984 |
49468-49478 |
NN |
denotes |
depression |
T11985 |
49458-49462 |
JJ |
denotes |
long |
T11986 |
49463-49467 |
NN |
denotes |
term |
T11987 |
49462-49463 |
HYPH |
denotes |
- |
T11988 |
49479-49480 |
-LRB- |
denotes |
[ |
T11989 |
49480-49482 |
CD |
denotes |
79 |
T11990 |
49482-49483 |
-RRB- |
denotes |
] |
T11991 |
49484-49487 |
CC |
denotes |
and |
T11992 |
49488-49492 |
RB |
denotes |
thus |
T11993 |
49508-49516 |
VBN |
denotes |
impaired |
T11994 |
49493-49495 |
VB |
denotes |
be |
T11995 |
49496-49507 |
RB |
denotes |
selectively |
T11996 |
49517-49519 |
IN |
denotes |
by |
T11997 |
49520-49524 |
NN |
denotes |
GluR |
T11998 |
49525-49526 |
NN |
denotes |
B |
T11999 |
49524-49525 |
HYPH |
denotes |
- |
T12000 |
49527-49536 |
NN |
denotes |
depletion |
T12001 |
49536-49537 |
. |
denotes |
. |
T12002 |
49537-49704 |
sentence |
denotes |
Physiological experiments to assess these hypotheses will ideally make use of even more restricted genetic modifications with completely undisturbed input structures. |
T12003 |
49538-49551 |
JJ |
denotes |
Physiological |
T12004 |
49552-49563 |
NNS |
denotes |
experiments |
T12005 |
49604-49608 |
VB |
denotes |
make |
T12006 |
49564-49566 |
TO |
denotes |
to |
T12007 |
49567-49573 |
VB |
denotes |
assess |
T12008 |
49574-49579 |
DT |
denotes |
these |
T12009 |
49580-49590 |
NNS |
denotes |
hypotheses |
T12010 |
49591-49595 |
MD |
denotes |
will |
T12011 |
49596-49603 |
RB |
denotes |
ideally |
T12012 |
49609-49612 |
NN |
denotes |
use |
T12013 |
49613-49615 |
IN |
denotes |
of |
T12014 |
49616-49620 |
RB |
denotes |
even |
T12015 |
49621-49625 |
RBR |
denotes |
more |
T12016 |
49626-49636 |
VBN |
denotes |
restricted |
T12017 |
49645-49658 |
NNS |
denotes |
modifications |
T12018 |
49637-49644 |
JJ |
denotes |
genetic |
T12019 |
49659-49663 |
IN |
denotes |
with |
T12020 |
49664-49674 |
RB |
denotes |
completely |
T12021 |
49675-49686 |
JJ |
denotes |
undisturbed |
T12022 |
49693-49703 |
NNS |
denotes |
structures |
T12023 |
49687-49692 |
NN |
denotes |
input |
T12024 |
49703-49704 |
. |
denotes |
. |
T12025 |
49704-49823 |
sentence |
denotes |
One possibility would be Cre-mediated GluR-B depletion and GluR-B(Q) expression in piriform cortex as suggested above. |
T12026 |
49705-49708 |
CD |
denotes |
One |
T12027 |
49709-49720 |
NN |
denotes |
possibility |
T12028 |
49727-49729 |
VB |
denotes |
be |
T12029 |
49721-49726 |
MD |
denotes |
would |
T12030 |
49730-49733 |
NN |
denotes |
Cre |
T12031 |
49734-49742 |
VBN |
denotes |
mediated |
T12032 |
49733-49734 |
HYPH |
denotes |
- |
T12033 |
49750-49759 |
NN |
denotes |
depletion |
T12034 |
49743-49747 |
NN |
denotes |
GluR |
T12035 |
49748-49749 |
NN |
denotes |
B |
T12036 |
49747-49748 |
HYPH |
denotes |
- |
T12037 |
49760-49763 |
CC |
denotes |
and |
T12038 |
49764-49768 |
NN |
denotes |
GluR |
T12039 |
49769-49770 |
NN |
denotes |
B |
T12040 |
49768-49769 |
HYPH |
denotes |
- |
T12041 |
49774-49784 |
NN |
denotes |
expression |
T12042 |
49770-49771 |
-LRB- |
denotes |
( |
T12043 |
49771-49772 |
NN |
denotes |
Q |
T12044 |
49772-49773 |
-RRB- |
denotes |
) |
T12045 |
49785-49787 |
IN |
denotes |
in |
T12046 |
49788-49796 |
JJ |
denotes |
piriform |
T12047 |
49797-49803 |
NN |
denotes |
cortex |
T12048 |
49804-49806 |
IN |
denotes |
as |
T12049 |
49807-49816 |
VBN |
denotes |
suggested |
T12050 |
49817-49822 |
RB |
denotes |
above |
T12051 |
49822-49823 |
. |
denotes |
. |
T12235 |
49825-49836 |
VBG |
denotes |
Correlating |
T12236 |
49837-49849 |
JJ |
denotes |
Quantitative |
T12237 |
49850-49858 |
NN |
denotes |
Behavior |
T12238 |
49859-49862 |
CC |
denotes |
and |
T12239 |
49863-49869 |
NN |
denotes |
Mosaic |
T12240 |
49875-49885 |
NN |
denotes |
Expression |
T12241 |
49870-49874 |
NN |
denotes |
Gene |
T12242 |
49886-49889 |
IN |
denotes |
for |
T12243 |
49890-49900 |
VBG |
denotes |
Dissecting |
T12244 |
49901-49911 |
NNS |
denotes |
Phenotypes |
T12245 |
49911-50173 |
sentence |
denotes |
A critical step in discerning the discrimination and learning phenotypes from the memory phenotype was the observation of increased variability in the memory of the GluR-B knockout animals and, subsequently, the individual analyses of protein expression levels. |
T12246 |
49912-49913 |
DT |
denotes |
A |
T12247 |
49923-49927 |
NN |
denotes |
step |
T12248 |
49914-49922 |
JJ |
denotes |
critical |
T12249 |
50011-50014 |
VBD |
denotes |
was |
T12250 |
49928-49930 |
IN |
denotes |
in |
T12251 |
49931-49941 |
VBG |
denotes |
discerning |
T12252 |
49942-49945 |
DT |
denotes |
the |
T12253 |
49946-49960 |
NN |
denotes |
discrimination |
T12254 |
49961-49964 |
CC |
denotes |
and |
T12255 |
49965-49973 |
VBG |
denotes |
learning |
T12256 |
49974-49984 |
NNS |
denotes |
phenotypes |
T12257 |
49985-49989 |
IN |
denotes |
from |
T12258 |
49990-49993 |
DT |
denotes |
the |
T12259 |
50001-50010 |
NN |
denotes |
phenotype |
T12260 |
49994-50000 |
NN |
denotes |
memory |
T12261 |
50015-50018 |
DT |
denotes |
the |
T12262 |
50019-50030 |
NN |
denotes |
observation |
T12263 |
50031-50033 |
IN |
denotes |
of |
T12264 |
50034-50043 |
VBN |
denotes |
increased |
T12265 |
50044-50055 |
NN |
denotes |
variability |
T12266 |
50056-50058 |
IN |
denotes |
in |
T12267 |
50059-50062 |
DT |
denotes |
the |
T12268 |
50063-50069 |
NN |
denotes |
memory |
T12269 |
50070-50072 |
IN |
denotes |
of |
T12270 |
50073-50076 |
DT |
denotes |
the |
T12271 |
50093-50100 |
NNS |
denotes |
animals |
T12272 |
50077-50081 |
NN |
denotes |
GluR |
T12273 |
50082-50083 |
NN |
denotes |
B |
T12274 |
50081-50082 |
HYPH |
denotes |
- |
T12275 |
50084-50092 |
NN |
denotes |
knockout |
T12276 |
50101-50104 |
CC |
denotes |
and |
T12277 |
50104-50106 |
, |
denotes |
, |
T12278 |
50106-50118 |
RB |
denotes |
subsequently |
T12279 |
50135-50143 |
NNS |
denotes |
analyses |
T12280 |
50118-50120 |
, |
denotes |
, |
T12281 |
50120-50123 |
DT |
denotes |
the |
T12282 |
50124-50134 |
JJ |
denotes |
individual |
T12283 |
50144-50146 |
IN |
denotes |
of |
T12284 |
50147-50154 |
NN |
denotes |
protein |
T12285 |
50166-50172 |
NNS |
denotes |
levels |
T12286 |
50155-50165 |
NN |
denotes |
expression |
T12287 |
50172-50173 |
. |
denotes |
. |
T12288 |
50173-50348 |
sentence |
denotes |
We made use of the epigenetic variability in GluR-B excision that could be correlated to the variability in memory but showed no correlation to variability in discrimination. |
T12289 |
50174-50176 |
PRP |
denotes |
We |
T12290 |
50177-50181 |
VBD |
denotes |
made |
T12291 |
50182-50185 |
NN |
denotes |
use |
T12292 |
50186-50188 |
IN |
denotes |
of |
T12293 |
50189-50192 |
DT |
denotes |
the |
T12294 |
50204-50215 |
NN |
denotes |
variability |
T12295 |
50193-50203 |
JJ |
denotes |
epigenetic |
T12296 |
50216-50218 |
IN |
denotes |
in |
T12297 |
50219-50223 |
NN |
denotes |
GluR |
T12298 |
50224-50225 |
NN |
denotes |
B |
T12299 |
50223-50224 |
HYPH |
denotes |
- |
T12300 |
50226-50234 |
NN |
denotes |
excision |
T12301 |
50235-50239 |
WDT |
denotes |
that |
T12302 |
50249-50259 |
VBN |
denotes |
correlated |
T12303 |
50240-50245 |
MD |
denotes |
could |
T12304 |
50246-50248 |
VB |
denotes |
be |
T12305 |
50260-50262 |
IN |
denotes |
to |
T12306 |
50263-50266 |
DT |
denotes |
the |
T12307 |
50267-50278 |
NN |
denotes |
variability |
T12308 |
50279-50281 |
IN |
denotes |
in |
T12309 |
50282-50288 |
NN |
denotes |
memory |
T12310 |
50289-50292 |
CC |
denotes |
but |
T12311 |
50293-50299 |
VBD |
denotes |
showed |
T12312 |
50300-50302 |
DT |
denotes |
no |
T12313 |
50303-50314 |
NN |
denotes |
correlation |
T12314 |
50315-50317 |
IN |
denotes |
to |
T12315 |
50318-50329 |
NN |
denotes |
variability |
T12316 |
50330-50332 |
IN |
denotes |
in |
T12317 |
50333-50347 |
NN |
denotes |
discrimination |
T12318 |
50347-50348 |
. |
denotes |
. |
T12319 |
50348-50605 |
sentence |
denotes |
The analysis of quantitative trait loci (for review, see [80]), or classically correlating different behavioral phenotypes within a truly wild-type population [81–84], also attempts to find common or distinct genetic origins of different behavioral traits. |
T12320 |
50349-50352 |
DT |
denotes |
The |
T12321 |
50353-50361 |
NN |
denotes |
analysis |
T12322 |
50522-50530 |
VBZ |
denotes |
attempts |
T12323 |
50362-50364 |
IN |
denotes |
of |
T12324 |
50365-50377 |
JJ |
denotes |
quantitative |
T12325 |
50378-50383 |
NN |
denotes |
trait |
T12326 |
50384-50388 |
NNS |
denotes |
loci |
T12327 |
50389-50390 |
-LRB- |
denotes |
( |
T12328 |
50402-50405 |
VBP |
denotes |
see |
T12329 |
50390-50393 |
IN |
denotes |
for |
T12330 |
50394-50400 |
NN |
denotes |
review |
T12331 |
50400-50402 |
, |
denotes |
, |
T12332 |
50406-50407 |
-LRB- |
denotes |
[ |
T12333 |
50407-50409 |
CD |
denotes |
80 |
T12334 |
50409-50410 |
-RRB- |
denotes |
] |
T12335 |
50410-50411 |
-RRB- |
denotes |
) |
T12336 |
50411-50413 |
, |
denotes |
, |
T12337 |
50413-50415 |
CC |
denotes |
or |
T12338 |
50416-50427 |
RB |
denotes |
classically |
T12339 |
50428-50439 |
VBG |
denotes |
correlating |
T12340 |
50461-50471 |
NNS |
denotes |
phenotypes |
T12341 |
50440-50449 |
JJ |
denotes |
different |
T12342 |
50450-50460 |
JJ |
denotes |
behavioral |
T12343 |
50472-50478 |
IN |
denotes |
within |
T12344 |
50479-50480 |
DT |
denotes |
a |
T12345 |
50497-50507 |
NN |
denotes |
population |
T12346 |
50481-50486 |
RB |
denotes |
truly |
T12347 |
50487-50491 |
JJ |
denotes |
wild |
T12348 |
50492-50496 |
NN |
denotes |
type |
T12349 |
50491-50492 |
HYPH |
denotes |
- |
T12350 |
50508-50509 |
-LRB- |
denotes |
[ |
T12351 |
50509-50511 |
CD |
denotes |
81 |
T12352 |
50511-50512 |
SYM |
denotes |
– |
T12353 |
50512-50514 |
CD |
denotes |
84 |
T12354 |
50514-50515 |
-RRB- |
denotes |
] |
T12355 |
50515-50517 |
, |
denotes |
, |
T12356 |
50517-50521 |
RB |
denotes |
also |
T12357 |
50531-50533 |
TO |
denotes |
to |
T12358 |
50534-50538 |
VB |
denotes |
find |
T12359 |
50539-50545 |
JJ |
denotes |
common |
T12360 |
50566-50573 |
NNS |
denotes |
origins |
T12361 |
50546-50548 |
CC |
denotes |
or |
T12362 |
50549-50557 |
JJ |
denotes |
distinct |
T12363 |
50558-50565 |
JJ |
denotes |
genetic |
T12364 |
50574-50576 |
IN |
denotes |
of |
T12365 |
50577-50586 |
JJ |
denotes |
different |
T12366 |
50598-50604 |
NNS |
denotes |
traits |
T12367 |
50587-50597 |
JJ |
denotes |
behavioral |
T12368 |
50604-50605 |
. |
denotes |
. |
T12369 |
50605-50704 |
sentence |
denotes |
These attempts undoubtedly contribute significantly to unraveling the molecular basis of behavior. |
T12370 |
50606-50611 |
DT |
denotes |
These |
T12371 |
50612-50620 |
NNS |
denotes |
attempts |
T12372 |
50633-50643 |
VBP |
denotes |
contribute |
T12373 |
50621-50632 |
RB |
denotes |
undoubtedly |
T12374 |
50644-50657 |
RB |
denotes |
significantly |
T12375 |
50658-50660 |
IN |
denotes |
to |
T12376 |
50661-50671 |
VBG |
denotes |
unraveling |
T12377 |
50672-50675 |
DT |
denotes |
the |
T12378 |
50686-50691 |
NN |
denotes |
basis |
T12379 |
50676-50685 |
JJ |
denotes |
molecular |
T12380 |
50692-50694 |
IN |
denotes |
of |
T12381 |
50695-50703 |
NN |
denotes |
behavior |
T12382 |
50703-50704 |
. |
denotes |
. |
T12383 |
50704-50898 |
sentence |
denotes |
Due to subtle and multigenic differences between different strains of rodents or different individuals in a wild-type population, however, they suffer from a rather low “signal-to-noise” ratio. |
T12384 |
50705-50708 |
IN |
denotes |
Due |
T12385 |
50849-50855 |
VBP |
denotes |
suffer |
T12386 |
50709-50711 |
IN |
denotes |
to |
T12387 |
50712-50718 |
JJ |
denotes |
subtle |
T12388 |
50734-50745 |
NNS |
denotes |
differences |
T12389 |
50719-50722 |
CC |
denotes |
and |
T12390 |
50723-50733 |
JJ |
denotes |
multigenic |
T12391 |
50746-50753 |
IN |
denotes |
between |
T12392 |
50754-50763 |
JJ |
denotes |
different |
T12393 |
50764-50771 |
NNS |
denotes |
strains |
T12394 |
50772-50774 |
IN |
denotes |
of |
T12395 |
50775-50782 |
NNS |
denotes |
rodents |
T12396 |
50783-50785 |
CC |
denotes |
or |
T12397 |
50786-50795 |
JJ |
denotes |
different |
T12398 |
50796-50807 |
NNS |
denotes |
individuals |
T12399 |
50808-50810 |
IN |
denotes |
in |
T12400 |
50811-50812 |
DT |
denotes |
a |
T12401 |
50823-50833 |
NN |
denotes |
population |
T12402 |
50813-50817 |
JJ |
denotes |
wild |
T12403 |
50818-50822 |
NN |
denotes |
type |
T12404 |
50817-50818 |
HYPH |
denotes |
- |
T12405 |
50833-50835 |
, |
denotes |
, |
T12406 |
50835-50842 |
RB |
denotes |
however |
T12407 |
50842-50844 |
, |
denotes |
, |
T12408 |
50844-50848 |
PRP |
denotes |
they |
T12409 |
50856-50860 |
IN |
denotes |
from |
T12410 |
50861-50862 |
DT |
denotes |
a |
T12411 |
50892-50897 |
NN |
denotes |
ratio |
T12412 |
50863-50869 |
RB |
denotes |
rather |
T12413 |
50870-50873 |
JJ |
denotes |
low |
T12414 |
50874-50875 |
`` |
denotes |
“ |
T12415 |
50875-50881 |
NN |
denotes |
signal |
T12416 |
50881-50882 |
HYPH |
denotes |
- |
T12417 |
50882-50884 |
IN |
denotes |
to |
T12418 |
50884-50885 |
HYPH |
denotes |
- |
T12419 |
50885-50890 |
NN |
denotes |
noise |
T12420 |
50890-50891 |
'' |
denotes |
” |
T12421 |
50897-50898 |
. |
denotes |
. |
T12422 |
50898-50996 |
sentence |
denotes |
Differences in individual genes are rather small compared with the vast number of genes involved. |
T12423 |
50899-50910 |
NNS |
denotes |
Differences |
T12424 |
50931-50934 |
VBP |
denotes |
are |
T12425 |
50911-50913 |
IN |
denotes |
in |
T12426 |
50914-50924 |
JJ |
denotes |
individual |
T12427 |
50925-50930 |
NNS |
denotes |
genes |
T12428 |
50935-50941 |
RB |
denotes |
rather |
T12429 |
50942-50947 |
JJ |
denotes |
small |
T12430 |
50948-50956 |
VBN |
denotes |
compared |
T12431 |
50957-50961 |
IN |
denotes |
with |
T12432 |
50962-50965 |
DT |
denotes |
the |
T12433 |
50971-50977 |
NN |
denotes |
number |
T12434 |
50966-50970 |
JJ |
denotes |
vast |
T12435 |
50978-50980 |
IN |
denotes |
of |
T12436 |
50981-50986 |
NNS |
denotes |
genes |
T12437 |
50987-50995 |
VBN |
denotes |
involved |
T12438 |
50995-50996 |
. |
denotes |
. |
T12439 |
50996-51288 |
sentence |
denotes |
As a result, purely correlating behavioral traits within a wild-type population usually remains rather descriptive, whereas quantitative trait loci analysis is capable of revealing multigenic basis of behavioral traits but usually lacks the power to identify the individual genes themselves. |
T12440 |
50997-50999 |
IN |
denotes |
As |
T12441 |
51085-51092 |
VBZ |
denotes |
remains |
T12442 |
51000-51001 |
DT |
denotes |
a |
T12443 |
51002-51008 |
NN |
denotes |
result |
T12444 |
51008-51010 |
, |
denotes |
, |
T12445 |
51010-51016 |
RB |
denotes |
purely |
T12446 |
51017-51028 |
VBG |
denotes |
correlating |
T12447 |
51040-51046 |
NNS |
denotes |
traits |
T12448 |
51029-51039 |
JJ |
denotes |
behavioral |
T12449 |
51047-51053 |
IN |
denotes |
within |
T12450 |
51054-51055 |
DT |
denotes |
a |
T12451 |
51066-51076 |
NN |
denotes |
population |
T12452 |
51056-51060 |
JJ |
denotes |
wild |
T12453 |
51061-51065 |
NN |
denotes |
type |
T12454 |
51060-51061 |
HYPH |
denotes |
- |
T12455 |
51077-51084 |
RB |
denotes |
usually |
T12456 |
51093-51099 |
RB |
denotes |
rather |
T12457 |
51100-51111 |
JJ |
denotes |
descriptive |
T12458 |
51111-51113 |
, |
denotes |
, |
T12459 |
51113-51120 |
IN |
denotes |
whereas |
T12460 |
51154-51156 |
VBZ |
denotes |
is |
T12461 |
51121-51133 |
JJ |
denotes |
quantitative |
T12462 |
51134-51139 |
NN |
denotes |
trait |
T12463 |
51140-51144 |
NNS |
denotes |
loci |
T12464 |
51145-51153 |
NN |
denotes |
analysis |
T12465 |
51157-51164 |
JJ |
denotes |
capable |
T12466 |
51165-51167 |
IN |
denotes |
of |
T12467 |
51168-51177 |
VBG |
denotes |
revealing |
T12468 |
51178-51188 |
JJ |
denotes |
multigenic |
T12469 |
51189-51194 |
NN |
denotes |
basis |
T12470 |
51195-51197 |
IN |
denotes |
of |
T12471 |
51198-51208 |
JJ |
denotes |
behavioral |
T12472 |
51209-51215 |
NNS |
denotes |
traits |
T12473 |
51216-51219 |
CC |
denotes |
but |
T12474 |
51220-51227 |
RB |
denotes |
usually |
T12475 |
51228-51233 |
VBZ |
denotes |
lacks |
T12476 |
51234-51237 |
DT |
denotes |
the |
T12477 |
51238-51243 |
NN |
denotes |
power |
T12478 |
51244-51246 |
TO |
denotes |
to |
T12479 |
51247-51255 |
VB |
denotes |
identify |
T12480 |
51256-51259 |
DT |
denotes |
the |
T12481 |
51271-51276 |
NNS |
denotes |
genes |
T12482 |
51260-51270 |
JJ |
denotes |
individual |
T12483 |
51277-51287 |
PRP |
denotes |
themselves |
T12484 |
51287-51288 |
. |
denotes |
. |
T12485 |
51288-51716 |
sentence |
denotes |
Herein, we described a way to enhance the signal-to-noise ratio by making use of the mosaic expression often associated with transgenic approaches: combining the advantages of “classical” genetic manipulation—namely, that the target of the manipulation is well defined—with the possibility to analyze variability, might also in future provide novel ways to define molecular and cellular correlates of complex behavioral traits. |
T12486 |
51289-51295 |
RB |
denotes |
Herein |
T12487 |
51300-51309 |
VBD |
denotes |
described |
T12488 |
51295-51297 |
, |
denotes |
, |
T12489 |
51297-51299 |
PRP |
denotes |
we |
T12490 |
51624-51631 |
VB |
denotes |
provide |
T12491 |
51310-51311 |
DT |
denotes |
a |
T12492 |
51312-51315 |
NN |
denotes |
way |
T12493 |
51316-51318 |
TO |
denotes |
to |
T12494 |
51319-51326 |
VB |
denotes |
enhance |
T12495 |
51327-51330 |
DT |
denotes |
the |
T12496 |
51347-51352 |
NN |
denotes |
ratio |
T12497 |
51331-51337 |
NN |
denotes |
signal |
T12498 |
51337-51338 |
HYPH |
denotes |
- |
T12499 |
51338-51340 |
IN |
denotes |
to |
T12500 |
51340-51341 |
HYPH |
denotes |
- |
T12501 |
51341-51346 |
NN |
denotes |
noise |
T12502 |
51353-51355 |
IN |
denotes |
by |
T12503 |
51356-51362 |
VBG |
denotes |
making |
T12504 |
51363-51366 |
NN |
denotes |
use |
T12505 |
51367-51369 |
IN |
denotes |
of |
T12506 |
51370-51373 |
DT |
denotes |
the |
T12507 |
51381-51391 |
NN |
denotes |
expression |
T12508 |
51374-51380 |
NN |
denotes |
mosaic |
T12509 |
51392-51397 |
RB |
denotes |
often |
T12510 |
51398-51408 |
VBN |
denotes |
associated |
T12511 |
51409-51413 |
IN |
denotes |
with |
T12512 |
51414-51424 |
JJ |
denotes |
transgenic |
T12513 |
51425-51435 |
NNS |
denotes |
approaches |
T12514 |
51435-51437 |
: |
denotes |
: |
T12515 |
51437-51446 |
VBG |
denotes |
combining |
T12516 |
51447-51450 |
DT |
denotes |
the |
T12517 |
51451-51461 |
NNS |
denotes |
advantages |
T12518 |
51462-51464 |
IN |
denotes |
of |
T12519 |
51465-51466 |
`` |
denotes |
“ |
T12520 |
51485-51497 |
NN |
denotes |
manipulation |
T12521 |
51466-51475 |
JJ |
denotes |
classical |
T12522 |
51475-51476 |
'' |
denotes |
” |
T12523 |
51477-51484 |
JJ |
denotes |
genetic |
T12524 |
51497-51498 |
: |
denotes |
— |
T12525 |
51498-51504 |
RB |
denotes |
namely |
T12526 |
51542-51544 |
VBZ |
denotes |
is |
T12527 |
51504-51506 |
, |
denotes |
, |
T12528 |
51506-51510 |
IN |
denotes |
that |
T12529 |
51511-51514 |
DT |
denotes |
the |
T12530 |
51515-51521 |
NN |
denotes |
target |
T12531 |
51522-51524 |
IN |
denotes |
of |
T12532 |
51525-51528 |
DT |
denotes |
the |
T12533 |
51529-51541 |
NN |
denotes |
manipulation |
T12534 |
51545-51549 |
RB |
denotes |
well |
T12535 |
51550-51557 |
VBN |
denotes |
defined |
T12536 |
51557-51558 |
: |
denotes |
— |
T12537 |
51558-51562 |
IN |
denotes |
with |
T12538 |
51563-51566 |
DT |
denotes |
the |
T12539 |
51567-51578 |
NN |
denotes |
possibility |
T12540 |
51579-51581 |
TO |
denotes |
to |
T12541 |
51582-51589 |
VB |
denotes |
analyze |
T12542 |
51590-51601 |
NN |
denotes |
variability |
T12543 |
51601-51603 |
, |
denotes |
, |
T12544 |
51603-51608 |
MD |
denotes |
might |
T12545 |
51609-51613 |
RB |
denotes |
also |
T12546 |
51614-51616 |
IN |
denotes |
in |
T12547 |
51617-51623 |
NN |
denotes |
future |
T12548 |
51632-51637 |
JJ |
denotes |
novel |
T12549 |
51638-51642 |
NNS |
denotes |
ways |
T12550 |
51643-51645 |
TO |
denotes |
to |
T12551 |
51646-51652 |
VB |
denotes |
define |
T12552 |
51653-51662 |
JJ |
denotes |
molecular |
T12553 |
51676-51686 |
NNS |
denotes |
correlates |
T12554 |
51663-51666 |
CC |
denotes |
and |
T12555 |
51667-51675 |
JJ |
denotes |
cellular |
T12556 |
51687-51689 |
IN |
denotes |
of |
T12557 |
51690-51697 |
JJ |
denotes |
complex |
T12558 |
51709-51715 |
NNS |
denotes |
traits |
T12559 |
51698-51708 |
JJ |
denotes |
behavioral |
T12560 |
51715-51716 |
. |
denotes |
. |
T12561 |
51716-51854 |
sentence |
denotes |
In this study, we combined genetically induced manipulation of the AMPAR composition with quantitative behavioral and molecular analyses. |
T12562 |
51717-51719 |
IN |
denotes |
In |
T12563 |
51735-51743 |
VBD |
denotes |
combined |
T12564 |
51720-51724 |
DT |
denotes |
this |
T12565 |
51725-51730 |
NN |
denotes |
study |
T12566 |
51730-51732 |
, |
denotes |
, |
T12567 |
51732-51734 |
PRP |
denotes |
we |
T12568 |
51744-51755 |
RB |
denotes |
genetically |
T12569 |
51756-51763 |
VBN |
denotes |
induced |
T12570 |
51764-51776 |
NN |
denotes |
manipulation |
T12571 |
51777-51779 |
IN |
denotes |
of |
T12572 |
51780-51783 |
DT |
denotes |
the |
T12573 |
51790-51801 |
NN |
denotes |
composition |
T12574 |
51784-51789 |
NN |
denotes |
AMPAR |
T12575 |
51802-51806 |
IN |
denotes |
with |
T12576 |
51807-51819 |
JJ |
denotes |
quantitative |
T12577 |
51845-51853 |
NNS |
denotes |
analyses |
T12578 |
51820-51830 |
JJ |
denotes |
behavioral |
T12579 |
51831-51834 |
CC |
denotes |
and |
T12580 |
51835-51844 |
JJ |
denotes |
molecular |
T12581 |
51853-51854 |
. |
denotes |
. |
T12582 |
51854-52092 |
sentence |
denotes |
We could thus provide evidence for opposing roles of specific GluR-B manipulation and increased Ca2+ influx via AMPARs in olfactory discrimination/learning, and memory, potentially in the olfactory bulb and piriform cortex, respectively. |
T12583 |
51855-51857 |
PRP |
denotes |
We |
T12584 |
51869-51876 |
VB |
denotes |
provide |
T12585 |
51858-51863 |
MD |
denotes |
could |
T12586 |
51864-51868 |
RB |
denotes |
thus |
T12587 |
51877-51885 |
NN |
denotes |
evidence |
T12588 |
51886-51889 |
IN |
denotes |
for |
T12589 |
51890-51898 |
VBG |
denotes |
opposing |
T12590 |
51899-51904 |
NNS |
denotes |
roles |
T12591 |
51905-51907 |
IN |
denotes |
of |
T12592 |
51908-51916 |
JJ |
denotes |
specific |
T12593 |
51924-51936 |
NN |
denotes |
manipulation |
T12594 |
51917-51921 |
NN |
denotes |
GluR |
T12595 |
51922-51923 |
NN |
denotes |
B |
T12596 |
51921-51922 |
HYPH |
denotes |
- |
T12597 |
51937-51940 |
CC |
denotes |
and |
T12598 |
51941-51950 |
VBN |
denotes |
increased |
T12599 |
51956-51962 |
NN |
denotes |
influx |
T12600 |
51951-51954 |
NN |
denotes |
Ca2 |
T12601 |
51954-51955 |
SYM |
denotes |
+ |
T12602 |
51963-51966 |
IN |
denotes |
via |
T12603 |
51967-51973 |
NNS |
denotes |
AMPARs |
T12604 |
51974-51976 |
IN |
denotes |
in |
T12605 |
51977-51986 |
JJ |
denotes |
olfactory |
T12606 |
52002-52010 |
NN |
denotes |
learning |
T12607 |
51987-52001 |
NN |
denotes |
discrimination |
T12608 |
52001-52002 |
HYPH |
denotes |
/ |
T12609 |
52010-52012 |
, |
denotes |
, |
T12610 |
52012-52015 |
CC |
denotes |
and |
T12611 |
52016-52022 |
NN |
denotes |
memory |
T12612 |
52022-52024 |
, |
denotes |
, |
T12613 |
52024-52035 |
RB |
denotes |
potentially |
T12614 |
52036-52038 |
IN |
denotes |
in |
T12615 |
52039-52042 |
DT |
denotes |
the |
T12616 |
52053-52057 |
NN |
denotes |
bulb |
T12617 |
52043-52052 |
JJ |
denotes |
olfactory |
T12618 |
52058-52061 |
CC |
denotes |
and |
T12619 |
52062-52070 |
JJ |
denotes |
piriform |
T12620 |
52071-52077 |
NN |
denotes |
cortex |
T12621 |
52077-52079 |
, |
denotes |
, |
T12622 |
52079-52091 |
RB |
denotes |
respectively |
T12623 |
52091-52092 |
. |
denotes |
. |
T12624 |
52092-52404 |
sentence |
denotes |
To achieve this, we made use of the epigenetic variability in the extent of GluR-B ablation, which correlated with the variability in odor memory, but not in discrimination and learning; this finding was subsequently confirmed in GluR-B rescue mice with piriform cortex-specific transgenic expression of GluR-B. |
T12625 |
52093-52095 |
TO |
denotes |
To |
T12626 |
52096-52103 |
VB |
denotes |
achieve |
T12627 |
52113-52117 |
VBD |
denotes |
made |
T12628 |
52104-52108 |
DT |
denotes |
this |
T12629 |
52108-52110 |
, |
denotes |
, |
T12630 |
52110-52112 |
PRP |
denotes |
we |
T12631 |
52310-52319 |
VBN |
denotes |
confirmed |
T12632 |
52118-52121 |
NN |
denotes |
use |
T12633 |
52122-52124 |
IN |
denotes |
of |
T12634 |
52125-52128 |
DT |
denotes |
the |
T12635 |
52140-52151 |
NN |
denotes |
variability |
T12636 |
52129-52139 |
JJ |
denotes |
epigenetic |
T12637 |
52152-52154 |
IN |
denotes |
in |
T12638 |
52155-52158 |
DT |
denotes |
the |
T12639 |
52159-52165 |
NN |
denotes |
extent |
T12640 |
52166-52168 |
IN |
denotes |
of |
T12641 |
52169-52173 |
NN |
denotes |
GluR |
T12642 |
52174-52175 |
NN |
denotes |
B |
T12643 |
52173-52174 |
HYPH |
denotes |
- |
T12644 |
52176-52184 |
NN |
denotes |
ablation |
T12645 |
52184-52186 |
, |
denotes |
, |
T12646 |
52186-52191 |
WDT |
denotes |
which |
T12647 |
52192-52202 |
VBD |
denotes |
correlated |
T12648 |
52203-52207 |
IN |
denotes |
with |
T12649 |
52208-52211 |
DT |
denotes |
the |
T12650 |
52212-52223 |
NN |
denotes |
variability |
T12651 |
52224-52226 |
IN |
denotes |
in |
T12652 |
52227-52231 |
NN |
denotes |
odor |
T12653 |
52232-52238 |
NN |
denotes |
memory |
T12654 |
52238-52240 |
, |
denotes |
, |
T12655 |
52240-52243 |
CC |
denotes |
but |
T12656 |
52244-52247 |
RB |
denotes |
not |
T12657 |
52248-52250 |
IN |
denotes |
in |
T12658 |
52251-52265 |
NN |
denotes |
discrimination |
T12659 |
52266-52269 |
CC |
denotes |
and |
T12660 |
52270-52278 |
NN |
denotes |
learning |
T12661 |
52278-52279 |
: |
denotes |
; |
T12662 |
52280-52284 |
DT |
denotes |
this |
T12663 |
52285-52292 |
NN |
denotes |
finding |
T12664 |
52293-52296 |
VBD |
denotes |
was |
T12665 |
52297-52309 |
RB |
denotes |
subsequently |
T12666 |
52320-52322 |
IN |
denotes |
in |
T12667 |
52323-52327 |
NN |
denotes |
GluR |
T12668 |
52328-52329 |
NN |
denotes |
B |
T12669 |
52327-52328 |
HYPH |
denotes |
- |
T12670 |
52337-52341 |
NNS |
denotes |
mice |
T12671 |
52330-52336 |
NN |
denotes |
rescue |
T12672 |
52342-52346 |
IN |
denotes |
with |
T12673 |
52347-52355 |
JJ |
denotes |
piriform |
T12674 |
52356-52362 |
NN |
denotes |
cortex |
T12675 |
52363-52371 |
JJ |
denotes |
specific |
T12676 |
52362-52363 |
HYPH |
denotes |
- |
T12677 |
52383-52393 |
NN |
denotes |
expression |
T12678 |
52372-52382 |
JJ |
denotes |
transgenic |
T12679 |
52394-52396 |
IN |
denotes |
of |
T12680 |
52397-52401 |
NN |
denotes |
GluR |
T12681 |
52402-52403 |
NN |
denotes |
B |
T12682 |
52401-52402 |
HYPH |
denotes |
- |
T12683 |
52403-52404 |
. |
denotes |
. |
T12684 |
52404-52700 |
sentence |
denotes |
Extending these principles of combining quantitative behavioral analyses with minimal and dosed genetic interference, together with further physiological analyses, will ultimately pinpoint the neural circuitries underlying related, but distinct, behavioral traits in olfactory and other systems. |
T12685 |
52405-52414 |
VBG |
denotes |
Extending |
T12686 |
52585-52593 |
VB |
denotes |
pinpoint |
T12687 |
52415-52420 |
DT |
denotes |
these |
T12688 |
52421-52431 |
NNS |
denotes |
principles |
T12689 |
52432-52434 |
IN |
denotes |
of |
T12690 |
52435-52444 |
VBG |
denotes |
combining |
T12691 |
52445-52457 |
JJ |
denotes |
quantitative |
T12692 |
52469-52477 |
NNS |
denotes |
analyses |
T12693 |
52458-52468 |
JJ |
denotes |
behavioral |
T12694 |
52478-52482 |
IN |
denotes |
with |
T12695 |
52483-52490 |
JJ |
denotes |
minimal |
T12696 |
52509-52521 |
NN |
denotes |
interference |
T12697 |
52491-52494 |
CC |
denotes |
and |
T12698 |
52495-52500 |
VBN |
denotes |
dosed |
T12699 |
52501-52508 |
JJ |
denotes |
genetic |
T12700 |
52521-52523 |
, |
denotes |
, |
T12701 |
52523-52531 |
RB |
denotes |
together |
T12702 |
52532-52536 |
IN |
denotes |
with |
T12703 |
52537-52544 |
JJ |
denotes |
further |
T12704 |
52559-52567 |
NNS |
denotes |
analyses |
T12705 |
52545-52558 |
JJ |
denotes |
physiological |
T12706 |
52567-52569 |
, |
denotes |
, |
T12707 |
52569-52573 |
MD |
denotes |
will |
T12708 |
52574-52584 |
RB |
denotes |
ultimately |
T12709 |
52594-52597 |
DT |
denotes |
the |
T12710 |
52605-52616 |
NNS |
denotes |
circuitries |
T12711 |
52598-52604 |
JJ |
denotes |
neural |
T12712 |
52617-52627 |
VBG |
denotes |
underlying |
T12713 |
52628-52635 |
JJ |
denotes |
related |
T12714 |
52662-52668 |
NNS |
denotes |
traits |
T12715 |
52635-52637 |
, |
denotes |
, |
T12716 |
52637-52640 |
CC |
denotes |
but |
T12717 |
52641-52649 |
JJ |
denotes |
distinct |
T12718 |
52649-52651 |
, |
denotes |
, |
T12719 |
52651-52661 |
JJ |
denotes |
behavioral |
T12720 |
52669-52671 |
IN |
denotes |
in |
T12721 |
52672-52681 |
JJ |
denotes |
olfactory |
T12722 |
52692-52699 |
NNS |
denotes |
systems |
T12723 |
52682-52685 |
CC |
denotes |
and |
T12724 |
52686-52691 |
JJ |
denotes |
other |
T12725 |
52699-52700 |
. |
denotes |
. |
T12911 |
52725-52730 |
NN |
denotes |
Mouse |
T12912 |
52731-52736 |
NNS |
denotes |
lines |
T12913 |
52736-52786 |
sentence |
denotes |
The R26R line [85] was employed as Cre indicator. |
T12914 |
52737-52740 |
DT |
denotes |
The |
T12915 |
52746-52750 |
NN |
denotes |
line |
T12916 |
52741-52745 |
NN |
denotes |
R26R |
T12917 |
52760-52768 |
VBN |
denotes |
employed |
T12918 |
52751-52752 |
-LRB- |
denotes |
[ |
T12919 |
52752-52754 |
CD |
denotes |
85 |
T12920 |
52754-52755 |
-RRB- |
denotes |
] |
T12921 |
52756-52759 |
VBD |
denotes |
was |
T12922 |
52769-52771 |
IN |
denotes |
as |
T12923 |
52772-52775 |
NN |
denotes |
Cre |
T12924 |
52776-52785 |
NN |
denotes |
indicator |
T12925 |
52785-52786 |
. |
denotes |
. |
T12926 |
52786-52930 |
sentence |
denotes |
GluR-B ΔECS:FB mice were of mixed C57Bl/6 and NMRI genetic background and generated from TgCre4 (“Camkcre4” in [59]) and GluR-B+/neo [60] mice. |
T12927 |
52787-52791 |
NN |
denotes |
GluR |
T12928 |
52792-52798 |
NN |
denotes |
B ΔECS |
T12929 |
52791-52792 |
HYPH |
denotes |
- |
T12930 |
52802-52806 |
NNS |
denotes |
mice |
T12931 |
52798-52799 |
: |
denotes |
: |
T12932 |
52799-52801 |
NN |
denotes |
FB |
T12933 |
52807-52811 |
VBD |
denotes |
were |
T12934 |
52812-52814 |
IN |
denotes |
of |
T12935 |
52815-52820 |
VBN |
denotes |
mixed |
T12936 |
52846-52856 |
NN |
denotes |
background |
T12937 |
52821-52824 |
NN |
denotes |
C57 |
T12938 |
52824-52826 |
NN |
denotes |
Bl |
T12939 |
52826-52827 |
HYPH |
denotes |
/ |
T12940 |
52827-52828 |
CD |
denotes |
6 |
T12941 |
52829-52832 |
CC |
denotes |
and |
T12942 |
52833-52837 |
NN |
denotes |
NMRI |
T12943 |
52838-52845 |
JJ |
denotes |
genetic |
T12944 |
52857-52860 |
CC |
denotes |
and |
T12945 |
52861-52870 |
VBN |
denotes |
generated |
T12946 |
52871-52875 |
IN |
denotes |
from |
T12947 |
52876-52882 |
NN |
denotes |
TgCre4 |
T12948 |
52885-52893 |
NN |
denotes |
Camkcre4 |
T12949 |
52883-52884 |
-LRB- |
denotes |
( |
T12950 |
52884-52885 |
`` |
denotes |
“ |
T12951 |
52893-52894 |
'' |
denotes |
” |
T12952 |
52895-52897 |
IN |
denotes |
in |
T12953 |
52898-52899 |
-LRB- |
denotes |
[ |
T12954 |
52899-52901 |
CD |
denotes |
59 |
T12955 |
52901-52902 |
-RRB- |
denotes |
] |
T12956 |
52902-52903 |
-RRB- |
denotes |
) |
T12957 |
52904-52907 |
CC |
denotes |
and |
T12958 |
52908-52912 |
NN |
denotes |
GluR |
T12959 |
52913-52914 |
NN |
denotes |
B |
T12960 |
52912-52913 |
HYPH |
denotes |
- |
T12961 |
52925-52929 |
NNS |
denotes |
mice |
T12962 |
52914-52915 |
SYM |
denotes |
+ |
T12963 |
52915-52916 |
HYPH |
denotes |
/ |
T12964 |
52916-52919 |
NN |
denotes |
neo |
T12965 |
52920-52921 |
-LRB- |
denotes |
[ |
T12966 |
52921-52923 |
CD |
denotes |
60 |
T12967 |
52923-52924 |
-RRB- |
denotes |
] |
T12968 |
52929-52930 |
. |
denotes |
. |
T12969 |
52930-53138 |
sentence |
denotes |
GluR-B+/neo mice carry a wild-type GluR-B allele and a gene-targeted GluR-B allele in which the intron 11 sequence critical for Q/R site editing is replaced by a TK-neo gene flanked by loxP sites (“floxed”). |
T12970 |
52931-52935 |
NN |
denotes |
GluR |
T12971 |
52936-52937 |
NN |
denotes |
B |
T12972 |
52935-52936 |
HYPH |
denotes |
- |
T12973 |
52943-52947 |
NNS |
denotes |
mice |
T12974 |
52937-52938 |
SYM |
denotes |
+ |
T12975 |
52938-52939 |
HYPH |
denotes |
/ |
T12976 |
52939-52942 |
NN |
denotes |
neo |
T12977 |
52948-52953 |
VBP |
denotes |
carry |
T12978 |
52954-52955 |
DT |
denotes |
a |
T12979 |
52973-52979 |
NN |
denotes |
allele |
T12980 |
52956-52960 |
JJ |
denotes |
wild |
T12981 |
52961-52965 |
NN |
denotes |
type |
T12982 |
52960-52961 |
HYPH |
denotes |
- |
T12983 |
52966-52970 |
NN |
denotes |
GluR |
T12984 |
52971-52972 |
NN |
denotes |
B |
T12985 |
52970-52971 |
HYPH |
denotes |
- |
T12986 |
52980-52983 |
CC |
denotes |
and |
T12987 |
52984-52985 |
DT |
denotes |
a |
T12988 |
53007-53013 |
NN |
denotes |
allele |
T12989 |
52986-52990 |
NN |
denotes |
gene |
T12990 |
52991-52999 |
VBN |
denotes |
targeted |
T12991 |
52990-52991 |
HYPH |
denotes |
- |
T12992 |
53000-53004 |
NN |
denotes |
GluR |
T12993 |
53005-53006 |
NN |
denotes |
B |
T12994 |
53004-53005 |
HYPH |
denotes |
- |
T12995 |
53014-53016 |
IN |
denotes |
in |
T12996 |
53079-53087 |
VBN |
denotes |
replaced |
T12997 |
53017-53022 |
WDT |
denotes |
which |
T12998 |
53023-53026 |
DT |
denotes |
the |
T12999 |
53037-53045 |
NN |
denotes |
sequence |
T13000 |
53027-53033 |
NN |
denotes |
intron |
T13001 |
53034-53036 |
CD |
denotes |
11 |
T13002 |
53046-53054 |
JJ |
denotes |
critical |
T13003 |
53055-53058 |
IN |
denotes |
for |
T13004 |
53059-53060 |
NN |
denotes |
Q |
T13005 |
53061-53062 |
NN |
denotes |
R |
T13006 |
53060-53061 |
HYPH |
denotes |
/ |
T13007 |
53063-53067 |
NN |
denotes |
site |
T13008 |
53068-53075 |
NN |
denotes |
editing |
T13009 |
53076-53078 |
VBZ |
denotes |
is |
T13010 |
53088-53090 |
IN |
denotes |
by |
T13011 |
53091-53092 |
DT |
denotes |
a |
T13012 |
53100-53104 |
NN |
denotes |
gene |
T13013 |
53093-53095 |
NN |
denotes |
TK |
T13014 |
53096-53099 |
NN |
denotes |
neo |
T13015 |
53095-53096 |
HYPH |
denotes |
- |
T13016 |
53105-53112 |
VBN |
denotes |
flanked |
T13017 |
53113-53115 |
IN |
denotes |
by |
T13018 |
53116-53120 |
NN |
denotes |
loxP |
T13019 |
53121-53126 |
NNS |
denotes |
sites |
T13020 |
53127-53128 |
-LRB- |
denotes |
( |
T13021 |
53129-53135 |
VBN |
denotes |
floxed |
T13022 |
53128-53129 |
`` |
denotes |
“ |
T13023 |
53135-53136 |
'' |
denotes |
” |
T13024 |
53136-53137 |
-RRB- |
denotes |
) |
T13025 |
53137-53138 |
. |
denotes |
. |
T13026 |
53138-53222 |
sentence |
denotes |
GluR-B2lox mice [86] carry gene-targeted GluR-B alleles in which exon 11 is floxed. |
T13027 |
53139-53143 |
NN |
denotes |
GluR |
T13028 |
53144-53149 |
NN |
denotes |
B2lox |
T13029 |
53143-53144 |
HYPH |
denotes |
- |
T13030 |
53150-53154 |
NNS |
denotes |
mice |
T13031 |
53160-53165 |
VBP |
denotes |
carry |
T13032 |
53155-53156 |
-LRB- |
denotes |
[ |
T13033 |
53156-53158 |
CD |
denotes |
86 |
T13034 |
53158-53159 |
-RRB- |
denotes |
] |
T13035 |
53166-53170 |
NN |
denotes |
gene |
T13036 |
53171-53179 |
VBN |
denotes |
targeted |
T13037 |
53170-53171 |
HYPH |
denotes |
- |
T13038 |
53187-53194 |
NNS |
denotes |
alleles |
T13039 |
53180-53184 |
NN |
denotes |
GluR |
T13040 |
53185-53186 |
NN |
denotes |
B |
T13041 |
53184-53185 |
HYPH |
denotes |
- |
T13042 |
53195-53197 |
IN |
denotes |
in |
T13043 |
53215-53221 |
VBN |
denotes |
floxed |
T13044 |
53198-53203 |
WDT |
denotes |
which |
T13045 |
53204-53208 |
NN |
denotes |
exon |
T13046 |
53209-53211 |
CD |
denotes |
11 |
T13047 |
53212-53214 |
VBZ |
denotes |
is |
T13048 |
53221-53222 |
. |
denotes |
. |
T13049 |
53222-53320 |
sentence |
denotes |
GluR-B ΔFB mice were of C57Bl/6 genetic background and generated from TgCre4 and GluR-B2lox mice. |
T13050 |
53223-53227 |
NN |
denotes |
GluR |
T13051 |
53228-53233 |
NN |
denotes |
B ΔFB |
T13052 |
53227-53228 |
HYPH |
denotes |
- |
T13053 |
53234-53238 |
NNS |
denotes |
mice |
T13054 |
53239-53243 |
VBD |
denotes |
were |
T13055 |
53244-53246 |
IN |
denotes |
of |
T13056 |
53247-53252 |
NN |
denotes |
C57Bl |
T13057 |
53263-53273 |
NN |
denotes |
background |
T13058 |
53252-53253 |
HYPH |
denotes |
/ |
T13059 |
53253-53254 |
CD |
denotes |
6 |
T13060 |
53255-53262 |
JJ |
denotes |
genetic |
T13061 |
53274-53277 |
CC |
denotes |
and |
T13062 |
53278-53287 |
VBN |
denotes |
generated |
T13063 |
53288-53292 |
IN |
denotes |
from |
T13064 |
53293-53299 |
NN |
denotes |
TgCre4 |
T13065 |
53315-53319 |
NNS |
denotes |
mice |
T13066 |
53300-53303 |
CC |
denotes |
and |
T13067 |
53304-53308 |
NN |
denotes |
GluR |
T13068 |
53309-53314 |
NN |
denotes |
B2lox |
T13069 |
53308-53309 |
HYPH |
denotes |
- |
T13070 |
53319-53320 |
. |
denotes |
. |
T13071 |
53320-53546 |
sentence |
denotes |
TgCN12-itTA mice were generated as described for TgCN10-itTA mice (see Materials and Methods in [58]), and represent another founder line obtained from the same pronucleus injection, with more widespread forebrain expression. |
T13072 |
53321-53327 |
NN |
denotes |
TgCN12 |
T13073 |
53328-53332 |
NN |
denotes |
itTA |
T13074 |
53327-53328 |
HYPH |
denotes |
- |
T13075 |
53333-53337 |
NNS |
denotes |
mice |
T13076 |
53343-53352 |
VBN |
denotes |
generated |
T13077 |
53338-53342 |
VBD |
denotes |
were |
T13078 |
53353-53355 |
IN |
denotes |
as |
T13079 |
53356-53365 |
VBN |
denotes |
described |
T13080 |
53366-53369 |
IN |
denotes |
for |
T13081 |
53370-53376 |
NN |
denotes |
TgCN10 |
T13082 |
53377-53381 |
NN |
denotes |
itTA |
T13083 |
53376-53377 |
HYPH |
denotes |
- |
T13084 |
53382-53386 |
NNS |
denotes |
mice |
T13085 |
53387-53388 |
-LRB- |
denotes |
( |
T13086 |
53388-53391 |
VB |
denotes |
see |
T13087 |
53392-53401 |
NNS |
denotes |
Materials |
T13088 |
53402-53405 |
CC |
denotes |
and |
T13089 |
53406-53413 |
NNS |
denotes |
Methods |
T13090 |
53414-53416 |
IN |
denotes |
in |
T13091 |
53417-53418 |
-LRB- |
denotes |
[ |
T13092 |
53418-53420 |
CD |
denotes |
58 |
T13093 |
53420-53421 |
-RRB- |
denotes |
] |
T13094 |
53421-53422 |
-RRB- |
denotes |
) |
T13095 |
53422-53424 |
, |
denotes |
, |
T13096 |
53424-53427 |
CC |
denotes |
and |
T13097 |
53428-53437 |
VBP |
denotes |
represent |
T13098 |
53438-53445 |
DT |
denotes |
another |
T13099 |
53454-53458 |
NN |
denotes |
line |
T13100 |
53446-53453 |
NN |
denotes |
founder |
T13101 |
53459-53467 |
VBN |
denotes |
obtained |
T13102 |
53468-53472 |
IN |
denotes |
from |
T13103 |
53473-53476 |
DT |
denotes |
the |
T13104 |
53493-53502 |
NN |
denotes |
injection |
T13105 |
53477-53481 |
JJ |
denotes |
same |
T13106 |
53482-53492 |
NN |
denotes |
pronucleus |
T13107 |
53502-53504 |
, |
denotes |
, |
T13108 |
53504-53508 |
IN |
denotes |
with |
T13109 |
53509-53513 |
RBR |
denotes |
more |
T13110 |
53514-53524 |
JJ |
denotes |
widespread |
T13111 |
53535-53545 |
NN |
denotes |
expression |
T13112 |
53525-53534 |
NN |
denotes |
forebrain |
T13113 |
53545-53546 |
. |
denotes |
. |
T13114 |
53546-53751 |
sentence |
denotes |
For exogeneous expression of GFPGluR-B, the mouse line TgOCN1 was generated: an AseI fragment of plasmid pnlacZ/GFPGluR-B was injected into the pronucleus of oocytes obtained from DBA1/C57Bl/6 F1 hybrids. |
T13115 |
53547-53550 |
IN |
denotes |
For |
T13116 |
53673-53681 |
VBN |
denotes |
injected |
T13117 |
53551-53561 |
JJ |
denotes |
exogeneous |
T13118 |
53562-53572 |
NN |
denotes |
expression |
T13119 |
53573-53575 |
IN |
denotes |
of |
T13120 |
53576-53583 |
NN |
denotes |
GFPGluR |
T13121 |
53584-53585 |
NN |
denotes |
B |
T13122 |
53583-53584 |
HYPH |
denotes |
- |
T13123 |
53585-53587 |
, |
denotes |
, |
T13124 |
53587-53590 |
DT |
denotes |
the |
T13125 |
53597-53601 |
NN |
denotes |
line |
T13126 |
53591-53596 |
NN |
denotes |
mouse |
T13127 |
53613-53622 |
VBN |
denotes |
generated |
T13128 |
53602-53608 |
NN |
denotes |
TgOCN1 |
T13129 |
53609-53612 |
VBD |
denotes |
was |
T13130 |
53622-53624 |
: |
denotes |
: |
T13131 |
53624-53626 |
DT |
denotes |
an |
T13132 |
53632-53640 |
NN |
denotes |
fragment |
T13133 |
53627-53631 |
NN |
denotes |
AseI |
T13134 |
53641-53643 |
IN |
denotes |
of |
T13135 |
53644-53651 |
NN |
denotes |
plasmid |
T13136 |
53652-53658 |
NN |
denotes |
pnlacZ |
T13137 |
53658-53659 |
HYPH |
denotes |
/ |
T13138 |
53659-53666 |
NN |
denotes |
GFPGluR |
T13139 |
53667-53668 |
NN |
denotes |
B |
T13140 |
53666-53667 |
HYPH |
denotes |
- |
T13141 |
53669-53672 |
VBD |
denotes |
was |
T13142 |
53682-53686 |
IN |
denotes |
into |
T13143 |
53687-53690 |
DT |
denotes |
the |
T13144 |
53691-53701 |
NN |
denotes |
pronucleus |
T13145 |
53702-53704 |
IN |
denotes |
of |
T13146 |
53705-53712 |
NNS |
denotes |
oocytes |
T13147 |
53713-53721 |
VBN |
denotes |
obtained |
T13148 |
53722-53726 |
IN |
denotes |
from |
T13149 |
53727-53731 |
NN |
denotes |
DBA1 |
T13150 |
53732-53737 |
NN |
denotes |
C57Bl |
T13151 |
53731-53732 |
HYPH |
denotes |
/ |
T13152 |
53743-53750 |
NNS |
denotes |
hybrids |
T13153 |
53737-53738 |
HYPH |
denotes |
/ |
T13154 |
53738-53739 |
CD |
denotes |
6 |
T13155 |
53740-53742 |
NN |
denotes |
F1 |
T13156 |
53750-53751 |
. |
denotes |
. |
T13157 |
53751-53821 |
sentence |
denotes |
Positive founders were backcrossed into C57Bl/6 for further analysis. |
T13158 |
53752-53760 |
JJ |
denotes |
Positive |
T13159 |
53761-53769 |
NNS |
denotes |
founders |
T13160 |
53775-53786 |
VBN |
denotes |
backcrossed |
T13161 |
53770-53774 |
VBD |
denotes |
were |
T13162 |
53787-53791 |
IN |
denotes |
into |
T13163 |
53792-53797 |
NN |
denotes |
C57Bl |
T13164 |
53797-53798 |
HYPH |
denotes |
/ |
T13165 |
53798-53799 |
CD |
denotes |
6 |
T13166 |
53800-53803 |
IN |
denotes |
for |
T13167 |
53804-53811 |
JJ |
denotes |
further |
T13168 |
53812-53820 |
NN |
denotes |
analysis |
T13169 |
53820-53821 |
. |
denotes |
. |
T13170 |
53821-53944 |
sentence |
denotes |
Plasmid pnlacZ/GFPGluR-B was constructed from pnlacZ/GFPGluR-A [87] by replacing GluR-A cDNA with the rat cDNA for GluR-B. |
T13171 |
53822-53829 |
NN |
denotes |
Plasmid |
T13172 |
53830-53836 |
NN |
denotes |
pnlacZ |
T13173 |
53851-53862 |
VBN |
denotes |
constructed |
T13174 |
53836-53837 |
HYPH |
denotes |
/ |
T13175 |
53837-53844 |
NN |
denotes |
GFPGluR |
T13176 |
53845-53846 |
NN |
denotes |
B |
T13177 |
53844-53845 |
HYPH |
denotes |
- |
T13178 |
53847-53850 |
VBD |
denotes |
was |
T13179 |
53863-53867 |
IN |
denotes |
from |
T13180 |
53868-53874 |
NN |
denotes |
pnlacZ |
T13181 |
53883-53884 |
NN |
denotes |
A |
T13182 |
53874-53875 |
HYPH |
denotes |
/ |
T13183 |
53875-53882 |
NN |
denotes |
GFPGluR |
T13184 |
53882-53883 |
HYPH |
denotes |
- |
T13185 |
53885-53886 |
-LRB- |
denotes |
[ |
T13186 |
53886-53888 |
CD |
denotes |
87 |
T13187 |
53888-53889 |
-RRB- |
denotes |
] |
T13188 |
53890-53892 |
IN |
denotes |
by |
T13189 |
53893-53902 |
VBG |
denotes |
replacing |
T13190 |
53903-53907 |
NN |
denotes |
GluR |
T13191 |
53908-53909 |
NN |
denotes |
A |
T13192 |
53907-53908 |
HYPH |
denotes |
- |
T13193 |
53910-53914 |
NN |
denotes |
cDNA |
T13194 |
53915-53919 |
IN |
denotes |
with |
T13195 |
53920-53923 |
DT |
denotes |
the |
T13196 |
53928-53932 |
NN |
denotes |
cDNA |
T13197 |
53924-53927 |
NN |
denotes |
rat |
T13198 |
53933-53936 |
IN |
denotes |
for |
T13199 |
53937-53941 |
NN |
denotes |
GluR |
T13200 |
53942-53943 |
NN |
denotes |
B |
T13201 |
53941-53942 |
HYPH |
denotes |
- |
T13202 |
53943-53944 |
. |
denotes |
. |
T13203 |
53944-54106 |
sentence |
denotes |
Transgenic GFPGluR-B protein levels were measured in hippocampus of TgOCN1 mice also carrying a transgene for forebrain-specific homogeneous tTA expression [88]. |
T13204 |
53945-53955 |
JJ |
denotes |
Transgenic |
T13205 |
53966-53973 |
NN |
denotes |
protein |
T13206 |
53956-53963 |
NN |
denotes |
GFPGluR |
T13207 |
53964-53965 |
NN |
denotes |
B |
T13208 |
53963-53964 |
HYPH |
denotes |
- |
T13209 |
53974-53980 |
NNS |
denotes |
levels |
T13210 |
53986-53994 |
VBN |
denotes |
measured |
T13211 |
53981-53985 |
VBD |
denotes |
were |
T13212 |
53995-53997 |
IN |
denotes |
in |
T13213 |
53998-54009 |
NN |
denotes |
hippocampus |
T13214 |
54010-54012 |
IN |
denotes |
of |
T13215 |
54013-54019 |
NN |
denotes |
TgOCN1 |
T13216 |
54020-54024 |
NNS |
denotes |
mice |
T13217 |
54025-54029 |
RB |
denotes |
also |
T13218 |
54030-54038 |
VBG |
denotes |
carrying |
T13219 |
54039-54040 |
DT |
denotes |
a |
T13220 |
54041-54050 |
NN |
denotes |
transgene |
T13221 |
54051-54054 |
IN |
denotes |
for |
T13222 |
54055-54064 |
NN |
denotes |
forebrain |
T13223 |
54065-54073 |
JJ |
denotes |
specific |
T13224 |
54064-54065 |
HYPH |
denotes |
- |
T13225 |
54090-54100 |
NN |
denotes |
expression |
T13226 |
54074-54085 |
JJ |
denotes |
homogeneous |
T13227 |
54086-54089 |
NN |
denotes |
tTA |
T13228 |
54101-54102 |
-LRB- |
denotes |
[ |
T13229 |
54102-54104 |
CD |
denotes |
88 |
T13230 |
54104-54105 |
-RRB- |
denotes |
] |
T13231 |
54105-54106 |
. |
denotes |
. |
T13471 |
54402-54403 |
HYPH |
denotes |
- |
T13401 |
54108-54120 |
JJ |
denotes |
Experimental |
T13402 |
54121-54127 |
NNS |
denotes |
groups |
T13403 |
54127-54312 |
sentence |
denotes |
Mice heterozygous for TgCre4 and heterozygous for the TK-neo cassette in the GluR-B allele (GluR-BΔECS:FB) or homozygous for the floxed GluR-B (GluR-BΔFB) were used in the experiments. |
T13404 |
54128-54132 |
NNS |
denotes |
Mice |
T13405 |
54288-54292 |
VBN |
denotes |
used |
T13406 |
54133-54145 |
JJ |
denotes |
heterozygous |
T13407 |
54146-54149 |
IN |
denotes |
for |
T13408 |
54150-54156 |
NN |
denotes |
TgCre4 |
T13409 |
54157-54160 |
CC |
denotes |
and |
T13410 |
54161-54173 |
JJ |
denotes |
heterozygous |
T13411 |
54174-54177 |
IN |
denotes |
for |
T13412 |
54178-54181 |
DT |
denotes |
the |
T13413 |
54189-54197 |
NN |
denotes |
cassette |
T13414 |
54182-54184 |
NN |
denotes |
TK |
T13415 |
54185-54188 |
NN |
denotes |
neo |
T13416 |
54184-54185 |
HYPH |
denotes |
- |
T13417 |
54198-54200 |
IN |
denotes |
in |
T13418 |
54201-54204 |
DT |
denotes |
the |
T13419 |
54212-54218 |
NN |
denotes |
allele |
T13420 |
54205-54209 |
NN |
denotes |
GluR |
T13421 |
54210-54211 |
NN |
denotes |
B |
T13422 |
54209-54210 |
HYPH |
denotes |
- |
T13423 |
54219-54220 |
-LRB- |
denotes |
( |
T13424 |
54225-54230 |
NN |
denotes |
BΔECS |
T13425 |
54220-54224 |
NN |
denotes |
GluR |
T13426 |
54224-54225 |
HYPH |
denotes |
- |
T13427 |
54230-54231 |
: |
denotes |
: |
T13428 |
54231-54233 |
NN |
denotes |
FB |
T13429 |
54233-54234 |
-RRB- |
denotes |
) |
T13430 |
54235-54237 |
CC |
denotes |
or |
T13431 |
54238-54248 |
JJ |
denotes |
homozygous |
T13432 |
54249-54252 |
IN |
denotes |
for |
T13433 |
54253-54256 |
DT |
denotes |
the |
T13434 |
54269-54270 |
NN |
denotes |
B |
T13435 |
54257-54263 |
VBN |
denotes |
floxed |
T13436 |
54264-54268 |
NN |
denotes |
GluR |
T13437 |
54268-54269 |
HYPH |
denotes |
- |
T13438 |
54271-54272 |
-LRB- |
denotes |
( |
T13439 |
54277-54281 |
NN |
denotes |
BΔFB |
T13440 |
54272-54276 |
NN |
denotes |
GluR |
T13441 |
54276-54277 |
HYPH |
denotes |
- |
T13442 |
54281-54282 |
-RRB- |
denotes |
) |
T13443 |
54283-54287 |
VBD |
denotes |
were |
T13444 |
54293-54295 |
IN |
denotes |
in |
T13445 |
54296-54299 |
DT |
denotes |
the |
T13446 |
54300-54311 |
NNS |
denotes |
experiments |
T13447 |
54311-54312 |
. |
denotes |
. |
T13448 |
54312-54533 |
sentence |
denotes |
The “rescue” mice (GluR-BRescue) were positive for TgCre4, homozygous for the floxed GluR-B gene, and positive for the tet-sensitive responder transgene TgOCN1 and for the itTA expressing activator transgene TgCN12-itTA. |
T13449 |
54313-54316 |
DT |
denotes |
The |
T13450 |
54326-54330 |
NNS |
denotes |
mice |
T13451 |
54317-54318 |
`` |
denotes |
“ |
T13452 |
54318-54324 |
NN |
denotes |
rescue |
T13453 |
54324-54325 |
'' |
denotes |
” |
T13454 |
54346-54350 |
VBD |
denotes |
were |
T13455 |
54331-54332 |
-LRB- |
denotes |
( |
T13456 |
54332-54336 |
NN |
denotes |
GluR |
T13457 |
54337-54344 |
NN |
denotes |
BRescue |
T13458 |
54336-54337 |
HYPH |
denotes |
- |
T13459 |
54344-54345 |
-RRB- |
denotes |
) |
T13460 |
54351-54359 |
JJ |
denotes |
positive |
T13461 |
54360-54363 |
IN |
denotes |
for |
T13462 |
54364-54370 |
NN |
denotes |
TgCre4 |
T13463 |
54370-54372 |
, |
denotes |
, |
T13464 |
54372-54382 |
JJ |
denotes |
homozygous |
T13465 |
54383-54386 |
IN |
denotes |
for |
T13466 |
54387-54390 |
DT |
denotes |
the |
T13467 |
54405-54409 |
NN |
denotes |
gene |
T13468 |
54391-54397 |
VBN |
denotes |
floxed |
T13469 |
54398-54402 |
NN |
denotes |
GluR |
T13470 |
54403-54404 |
NN |
denotes |
B |
T13472 |
54409-54411 |
, |
denotes |
, |
T13473 |
54411-54414 |
CC |
denotes |
and |
T13474 |
54415-54423 |
JJ |
denotes |
positive |
T13475 |
54424-54427 |
IN |
denotes |
for |
T13476 |
54428-54431 |
DT |
denotes |
the |
T13477 |
54456-54465 |
NN |
denotes |
transgene |
T13478 |
54432-54435 |
NN |
denotes |
tet |
T13479 |
54436-54445 |
JJ |
denotes |
sensitive |
T13480 |
54435-54436 |
HYPH |
denotes |
- |
T13481 |
54446-54455 |
NN |
denotes |
responder |
T13482 |
54466-54472 |
NN |
denotes |
TgOCN1 |
T13483 |
54473-54476 |
CC |
denotes |
and |
T13484 |
54477-54480 |
IN |
denotes |
for |
T13485 |
54481-54484 |
DT |
denotes |
the |
T13486 |
54511-54520 |
NN |
denotes |
transgene |
T13487 |
54485-54489 |
NN |
denotes |
itTA |
T13488 |
54490-54500 |
VBG |
denotes |
expressing |
T13489 |
54501-54510 |
NN |
denotes |
activator |
T13490 |
54521-54527 |
NN |
denotes |
TgCN12 |
T13491 |
54528-54532 |
NN |
denotes |
itTA |
T13492 |
54527-54528 |
HYPH |
denotes |
- |
T13493 |
54532-54533 |
. |
denotes |
. |
T13560 |
54535-54542 |
NN |
denotes |
Control |
T13561 |
54543-54549 |
NNS |
denotes |
groups |
T13562 |
54549-54599 |
sentence |
denotes |
Littermate controls were used in all experiments. |
T13563 |
54550-54560 |
NN |
denotes |
Littermate |
T13564 |
54561-54569 |
NNS |
denotes |
controls |
T13565 |
54575-54579 |
VBN |
denotes |
used |
T13566 |
54570-54574 |
VBD |
denotes |
were |
T13567 |
54580-54582 |
IN |
denotes |
in |
T13568 |
54583-54586 |
DT |
denotes |
all |
T13569 |
54587-54598 |
NNS |
denotes |
experiments |
T13570 |
54598-54599 |
. |
denotes |
. |
T13571 |
54599-54671 |
sentence |
denotes |
GluR-B+/+ mice were used as controls in the task described in Figure 1. |
T13572 |
54600-54604 |
NN |
denotes |
GluR |
T13573 |
54605-54606 |
NN |
denotes |
B |
T13574 |
54604-54605 |
HYPH |
denotes |
- |
T13575 |
54610-54614 |
NNS |
denotes |
mice |
T13576 |
54606-54607 |
SYM |
denotes |
+ |
T13577 |
54607-54608 |
HYPH |
denotes |
/ |
T13578 |
54608-54609 |
SYM |
denotes |
+ |
T13579 |
54620-54624 |
VBN |
denotes |
used |
T13580 |
54615-54619 |
VBD |
denotes |
were |
T13581 |
54625-54627 |
IN |
denotes |
as |
T13582 |
54628-54636 |
NNS |
denotes |
controls |
T13583 |
54637-54639 |
IN |
denotes |
in |
T13584 |
54640-54643 |
DT |
denotes |
the |
T13585 |
54644-54648 |
NN |
denotes |
task |
T13586 |
54649-54658 |
VBN |
denotes |
described |
T13587 |
54659-54661 |
IN |
denotes |
in |
T13588 |
54662-54668 |
NN |
denotes |
Figure |
T13589 |
54669-54670 |
CD |
denotes |
1 |
T13590 |
54670-54671 |
. |
denotes |
. |
T13591 |
54671-54807 |
sentence |
denotes |
GluR-B+/2lox and GluR-B2lox/2lox (both negative for TgCre4) mice were used as controls in experiments described in Figures 2, 4, and 6. |
T13592 |
54672-54676 |
NN |
denotes |
GluR |
T13593 |
54677-54678 |
NN |
denotes |
B |
T13594 |
54676-54677 |
HYPH |
denotes |
- |
T13595 |
54732-54736 |
NNS |
denotes |
mice |
T13596 |
54678-54679 |
SYM |
denotes |
+ |
T13597 |
54679-54680 |
HYPH |
denotes |
/ |
T13598 |
54680-54684 |
NN |
denotes |
2lox |
T13599 |
54685-54688 |
CC |
denotes |
and |
T13600 |
54689-54693 |
NN |
denotes |
GluR |
T13601 |
54694-54699 |
NN |
denotes |
B2lox |
T13602 |
54693-54694 |
HYPH |
denotes |
- |
T13603 |
54699-54700 |
HYPH |
denotes |
/ |
T13604 |
54700-54704 |
NN |
denotes |
2lox |
T13605 |
54705-54706 |
-LRB- |
denotes |
( |
T13606 |
54706-54710 |
RB |
denotes |
both |
T13607 |
54711-54719 |
JJ |
denotes |
negative |
T13608 |
54720-54723 |
IN |
denotes |
for |
T13609 |
54724-54730 |
NN |
denotes |
TgCre4 |
T13610 |
54730-54731 |
-RRB- |
denotes |
) |
T13611 |
54742-54746 |
VBN |
denotes |
used |
T13612 |
54737-54741 |
VBD |
denotes |
were |
T13613 |
54747-54749 |
IN |
denotes |
as |
T13614 |
54750-54758 |
NNS |
denotes |
controls |
T13615 |
54759-54761 |
IN |
denotes |
in |
T13616 |
54762-54773 |
NNS |
denotes |
experiments |
T13617 |
54774-54783 |
VBN |
denotes |
described |
T13618 |
54784-54786 |
IN |
denotes |
in |
T13619 |
54787-54794 |
NNS |
denotes |
Figures |
T13620 |
54795-54796 |
CD |
denotes |
2 |
T13621 |
54796-54798 |
, |
denotes |
, |
T13622 |
54798-54799 |
CD |
denotes |
4 |
T13623 |
54799-54801 |
, |
denotes |
, |
T13624 |
54801-54804 |
CC |
denotes |
and |
T13625 |
54805-54806 |
CD |
denotes |
6 |
T13626 |
54806-54807 |
. |
denotes |
. |
T13627 |
54807-54990 |
sentence |
denotes |
For the GluR-BRescue experiments (Figure 6), controls positive for either TgCN12-itTA or TgOCN1 in a GluR-B+/2lox and GluR-B2lox/2lox (both negative for TgCre4) background were used. |
T13628 |
54808-54811 |
IN |
denotes |
For |
T13629 |
54985-54989 |
VBN |
denotes |
used |
T13630 |
54812-54815 |
DT |
denotes |
the |
T13631 |
54829-54840 |
NNS |
denotes |
experiments |
T13632 |
54816-54820 |
NN |
denotes |
GluR |
T13633 |
54821-54828 |
NN |
denotes |
BRescue |
T13634 |
54820-54821 |
HYPH |
denotes |
- |
T13635 |
54841-54842 |
-LRB- |
denotes |
( |
T13636 |
54842-54848 |
NN |
denotes |
Figure |
T13637 |
54849-54850 |
CD |
denotes |
6 |
T13638 |
54850-54851 |
-RRB- |
denotes |
) |
T13639 |
54851-54853 |
, |
denotes |
, |
T13640 |
54853-54861 |
NNS |
denotes |
controls |
T13641 |
54862-54870 |
JJ |
denotes |
positive |
T13642 |
54871-54874 |
IN |
denotes |
for |
T13643 |
54875-54881 |
CC |
denotes |
either |
T13644 |
54889-54893 |
NN |
denotes |
itTA |
T13645 |
54882-54888 |
NN |
denotes |
TgCN12 |
T13646 |
54888-54889 |
HYPH |
denotes |
- |
T13647 |
54894-54896 |
CC |
denotes |
or |
T13648 |
54897-54903 |
NN |
denotes |
TgOCN1 |
T13649 |
54904-54906 |
IN |
denotes |
in |
T13650 |
54907-54908 |
DT |
denotes |
a |
T13651 |
54969-54979 |
NN |
denotes |
background |
T13652 |
54909-54913 |
NN |
denotes |
GluR |
T13653 |
54914-54915 |
NN |
denotes |
B |
T13654 |
54913-54914 |
HYPH |
denotes |
- |
T13655 |
54915-54916 |
SYM |
denotes |
+ |
T13656 |
54916-54917 |
HYPH |
denotes |
/ |
T13657 |
54917-54921 |
NN |
denotes |
2lox |
T13658 |
54922-54925 |
CC |
denotes |
and |
T13659 |
54926-54930 |
NN |
denotes |
GluR |
T13660 |
54931-54936 |
NN |
denotes |
B2lox |
T13661 |
54930-54931 |
HYPH |
denotes |
- |
T13662 |
54936-54937 |
HYPH |
denotes |
/ |
T13663 |
54937-54941 |
NN |
denotes |
2lox |
T13664 |
54942-54943 |
-LRB- |
denotes |
( |
T13665 |
54943-54947 |
RB |
denotes |
both |
T13666 |
54948-54956 |
JJ |
denotes |
negative |
T13667 |
54957-54960 |
IN |
denotes |
for |
T13668 |
54961-54967 |
NN |
denotes |
TgCre4 |
T13669 |
54967-54968 |
-RRB- |
denotes |
) |
T13670 |
54980-54984 |
VBD |
denotes |
were |
T13671 |
54989-54990 |
. |
denotes |
. |
T13711 |
54992-55002 |
NN |
denotes |
Genotyping |
T13712 |
55002-55088 |
sentence |
denotes |
Mice were selected by PCR of mouse-tail DNA with specific primers as described below. |
T13713 |
55003-55007 |
NNS |
denotes |
Mice |
T13714 |
55013-55021 |
VBN |
denotes |
selected |
T13715 |
55008-55012 |
VBD |
denotes |
were |
T13716 |
55022-55024 |
IN |
denotes |
by |
T13717 |
55025-55028 |
NN |
denotes |
PCR |
T13718 |
55029-55031 |
IN |
denotes |
of |
T13719 |
55032-55037 |
NN |
denotes |
mouse |
T13720 |
55038-55042 |
NN |
denotes |
tail |
T13721 |
55037-55038 |
HYPH |
denotes |
- |
T13722 |
55043-55046 |
NN |
denotes |
DNA |
T13723 |
55047-55051 |
IN |
denotes |
with |
T13724 |
55052-55060 |
JJ |
denotes |
specific |
T13725 |
55061-55068 |
NNS |
denotes |
primers |
T13726 |
55069-55071 |
IN |
denotes |
as |
T13727 |
55072-55081 |
VBN |
denotes |
described |
T13728 |
55082-55087 |
RB |
denotes |
below |
T13729 |
55087-55088 |
. |
denotes |
. |
T13730 |
55088-55175 |
sentence |
denotes |
Indicated are the sequences and the approximate length of the amplified DNA fragments. |
T13731 |
55089-55098 |
VBN |
denotes |
Indicated |
T13732 |
55099-55102 |
VBP |
denotes |
are |
T13733 |
55103-55106 |
DT |
denotes |
the |
T13734 |
55107-55116 |
NNS |
denotes |
sequences |
T13735 |
55117-55120 |
CC |
denotes |
and |
T13736 |
55121-55124 |
DT |
denotes |
the |
T13737 |
55137-55143 |
NN |
denotes |
length |
T13738 |
55125-55136 |
JJ |
denotes |
approximate |
T13739 |
55144-55146 |
IN |
denotes |
of |
T13740 |
55147-55150 |
DT |
denotes |
the |
T13741 |
55165-55174 |
NNS |
denotes |
fragments |
T13742 |
55151-55160 |
VBN |
denotes |
amplified |
T13743 |
55161-55164 |
NN |
denotes |
DNA |
T13744 |
55174-55175 |
. |
denotes |
. |
T13745 |
55175-55287 |
sentence |
denotes |
TgCre4: rspCre1 (5′- ACCAGGTTCGTTCACTCATGG-3′) and rspCre2 (5′- AGGCTAAGTGCCTTCTCTACAC-3′), 200 basepairs (bp). |
T13746 |
55176-55182 |
NN |
denotes |
TgCre4 |
T13747 |
55182-55184 |
: |
denotes |
: |
T13748 |
55184-55191 |
NN |
denotes |
rspCre1 |
T13749 |
55283-55285 |
NN |
denotes |
bp |
T13750 |
55192-55193 |
-LRB- |
denotes |
( |
T13751 |
55219-55220 |
CD |
denotes |
3 |
T13752 |
55193-55194 |
CD |
denotes |
5 |
T13753 |
55194-55195 |
SYM |
denotes |
′ |
T13754 |
55195-55196 |
HYPH |
denotes |
- |
T13755 |
55197-55218 |
NN |
denotes |
ACCAGGTTCGTTCACTCATGG |
T13756 |
55218-55219 |
HYPH |
denotes |
- |
T13757 |
55220-55221 |
SYM |
denotes |
′ |
T13758 |
55221-55222 |
-RRB- |
denotes |
) |
T13759 |
55223-55226 |
CC |
denotes |
and |
T13760 |
55227-55234 |
NN |
denotes |
rspCre2 |
T13761 |
55235-55236 |
-LRB- |
denotes |
( |
T13762 |
55240-55262 |
NN |
denotes |
AGGCTAAGTGCCTTCTCTACAC |
T13763 |
55236-55237 |
CD |
denotes |
5 |
T13764 |
55237-55238 |
SYM |
denotes |
′ |
T13765 |
55238-55239 |
HYPH |
denotes |
- |
T13766 |
55262-55263 |
HYPH |
denotes |
- |
T13767 |
55263-55264 |
CD |
denotes |
3 |
T13768 |
55264-55265 |
SYM |
denotes |
′ |
T13769 |
55265-55266 |
-RRB- |
denotes |
) |
T13770 |
55266-55268 |
, |
denotes |
, |
T13771 |
55268-55271 |
CD |
denotes |
200 |
T13772 |
55272-55281 |
NNS |
denotes |
basepairs |
T13773 |
55282-55283 |
-LRB- |
denotes |
( |
T13774 |
55285-55286 |
-RRB- |
denotes |
) |
T13775 |
55286-55287 |
. |
denotes |
. |
T13776 |
55287-55462 |
sentence |
denotes |
GluR-Bneo: MH60 (5′- CACTCACAGCAATGAAGCAGGAC-3′), MH53a (5′- GAATGTTGATCATGTGTTTCCCTG-3′), and MH117 (5′- GTTCGAATTCGCCAATGACAAGACG-3′), wild-type: 500 bp and mutant: 400 bp. |
T13777 |
55288-55292 |
NN |
denotes |
GluR |
T13778 |
55293-55297 |
NN |
denotes |
Bneo |
T13779 |
55292-55293 |
HYPH |
denotes |
- |
T13780 |
55299-55303 |
NN |
denotes |
MH60 |
T13781 |
55297-55299 |
: |
denotes |
: |
T13782 |
55304-55305 |
-LRB- |
denotes |
( |
T13783 |
55309-55332 |
NN |
denotes |
CACTCACAGCAATGAAGCAGGAC |
T13784 |
55305-55306 |
CD |
denotes |
5 |
T13785 |
55306-55307 |
SYM |
denotes |
′ |
T13786 |
55307-55308 |
HYPH |
denotes |
- |
T13787 |
55332-55333 |
HYPH |
denotes |
- |
T13788 |
55333-55334 |
CD |
denotes |
3 |
T13789 |
55334-55335 |
SYM |
denotes |
′ |
T13790 |
55335-55336 |
-RRB- |
denotes |
) |
T13791 |
55336-55338 |
, |
denotes |
, |
T13792 |
55338-55343 |
NN |
denotes |
MH53a |
T13793 |
55344-55345 |
-LRB- |
denotes |
( |
T13794 |
55349-55373 |
NN |
denotes |
GAATGTTGATCATGTGTTTCCCTG |
T13795 |
55345-55346 |
CD |
denotes |
5 |
T13796 |
55346-55347 |
SYM |
denotes |
′ |
T13797 |
55347-55348 |
HYPH |
denotes |
- |
T13798 |
55373-55374 |
HYPH |
denotes |
- |
T13799 |
55374-55375 |
CD |
denotes |
3 |
T13800 |
55375-55376 |
SYM |
denotes |
′ |
T13801 |
55376-55377 |
-RRB- |
denotes |
) |
T13802 |
55377-55379 |
, |
denotes |
, |
T13803 |
55379-55382 |
CC |
denotes |
and |
T13804 |
55383-55388 |
NN |
denotes |
MH117 |
T13805 |
55389-55390 |
-LRB- |
denotes |
( |
T13806 |
55394-55419 |
NN |
denotes |
GTTCGAATTCGCCAATGACAAGACG |
T13807 |
55390-55391 |
CD |
denotes |
5 |
T13808 |
55391-55392 |
SYM |
denotes |
′ |
T13809 |
55392-55393 |
HYPH |
denotes |
- |
T13810 |
55419-55420 |
HYPH |
denotes |
- |
T13811 |
55420-55421 |
CD |
denotes |
3 |
T13812 |
55421-55422 |
SYM |
denotes |
′ |
T13813 |
55422-55423 |
-RRB- |
denotes |
) |
T13814 |
55423-55425 |
, |
denotes |
, |
T13815 |
55425-55429 |
JJ |
denotes |
wild |
T13816 |
55430-55434 |
NN |
denotes |
type |
T13817 |
55429-55430 |
HYPH |
denotes |
- |
T13818 |
55440-55442 |
NN |
denotes |
bp |
T13819 |
55434-55436 |
: |
denotes |
: |
T13820 |
55436-55439 |
CD |
denotes |
500 |
T13821 |
55443-55446 |
CC |
denotes |
and |
T13822 |
55447-55453 |
NN |
denotes |
mutant |
T13823 |
55459-55461 |
NN |
denotes |
bp |
T13824 |
55453-55455 |
: |
denotes |
: |
T13825 |
55455-55458 |
CD |
denotes |
400 |
T13826 |
55461-55462 |
. |
denotes |
. |
T13827 |
55462-55592 |
sentence |
denotes |
GluR-B2lox: VM12 (5′- GCGTAAGCCTGTGA AATACCTG-3′) and VM10 (5′- GTTGTCTAACAAGTTGTTGACC-3′), wild-type: 250 bp and mutant: 350 bp. |
T13828 |
55463-55467 |
NN |
denotes |
GluR |
T13829 |
55468-55473 |
NN |
denotes |
B2lox |
T13830 |
55467-55468 |
HYPH |
denotes |
- |
T13831 |
55475-55479 |
NN |
denotes |
VM12 |
T13832 |
55473-55475 |
: |
denotes |
: |
T13833 |
55480-55481 |
-LRB- |
denotes |
( |
T13834 |
55485-55508 |
NN |
denotes |
GCGTAAGCCTGTGA AATACCTG |
T13835 |
55481-55482 |
CD |
denotes |
5 |
T13836 |
55482-55483 |
SYM |
denotes |
′ |
T13837 |
55483-55484 |
HYPH |
denotes |
- |
T13838 |
55508-55509 |
HYPH |
denotes |
- |
T13839 |
55509-55510 |
CD |
denotes |
3 |
T13840 |
55510-55511 |
SYM |
denotes |
′ |
T13841 |
55511-55512 |
-RRB- |
denotes |
) |
T13842 |
55513-55516 |
CC |
denotes |
and |
T13843 |
55517-55521 |
NN |
denotes |
VM10 |
T13844 |
55522-55523 |
-LRB- |
denotes |
( |
T13845 |
55527-55549 |
NN |
denotes |
GTTGTCTAACAAGTTGTTGACC |
T13846 |
55523-55524 |
CD |
denotes |
5 |
T13847 |
55524-55525 |
SYM |
denotes |
′ |
T13848 |
55525-55526 |
HYPH |
denotes |
- |
T13849 |
55549-55550 |
HYPH |
denotes |
- |
T13850 |
55550-55551 |
CD |
denotes |
3 |
T13851 |
55551-55552 |
SYM |
denotes |
′ |
T13852 |
55552-55553 |
-RRB- |
denotes |
) |
T13853 |
55553-55555 |
, |
denotes |
, |
T13854 |
55555-55559 |
JJ |
denotes |
wild |
T13855 |
55560-55564 |
NN |
denotes |
type |
T13856 |
55559-55560 |
HYPH |
denotes |
- |
T13857 |
55570-55572 |
NN |
denotes |
bp |
T13858 |
55564-55566 |
: |
denotes |
: |
T13859 |
55566-55569 |
CD |
denotes |
250 |
T13860 |
55573-55576 |
CC |
denotes |
and |
T13861 |
55577-55583 |
NN |
denotes |
mutant |
T13862 |
55589-55591 |
NN |
denotes |
bp |
T13863 |
55583-55585 |
: |
denotes |
: |
T13864 |
55585-55588 |
CD |
denotes |
350 |
T13865 |
55591-55592 |
. |
denotes |
. |
T13866 |
55592-55701 |
sentence |
denotes |
TgOCN1: VM4 (5′- CTCCCAGACAACCATTACCTGTCC-3′) and GluR-B882BST (5′- CGAAGTATACTTAATTGTCGCTGTGTG-3′), 600 bp. |
T13867 |
55593-55599 |
NN |
denotes |
TgOCN1 |
T13868 |
55599-55601 |
: |
denotes |
: |
T13869 |
55601-55604 |
NN |
denotes |
VM4 |
T13870 |
55698-55700 |
NN |
denotes |
bp |
T13871 |
55605-55606 |
-LRB- |
denotes |
( |
T13872 |
55610-55634 |
NN |
denotes |
CTCCCAGACAACCATTACCTGTCC |
T13873 |
55606-55607 |
CD |
denotes |
5 |
T13874 |
55607-55608 |
SYM |
denotes |
′ |
T13875 |
55608-55609 |
HYPH |
denotes |
- |
T13876 |
55634-55635 |
HYPH |
denotes |
- |
T13877 |
55635-55636 |
CD |
denotes |
3 |
T13878 |
55636-55637 |
SYM |
denotes |
′ |
T13879 |
55637-55638 |
-RRB- |
denotes |
) |
T13880 |
55639-55642 |
CC |
denotes |
and |
T13881 |
55643-55647 |
NN |
denotes |
GluR |
T13882 |
55648-55655 |
NN |
denotes |
B882BST |
T13883 |
55647-55648 |
HYPH |
denotes |
- |
T13884 |
55656-55657 |
-LRB- |
denotes |
( |
T13885 |
55661-55688 |
NN |
denotes |
CGAAGTATACTTAATTGTCGCTGTGTG |
T13886 |
55657-55658 |
CD |
denotes |
5 |
T13887 |
55658-55659 |
SYM |
denotes |
′ |
T13888 |
55659-55660 |
HYPH |
denotes |
- |
T13889 |
55688-55689 |
HYPH |
denotes |
- |
T13890 |
55689-55690 |
CD |
denotes |
3 |
T13891 |
55690-55691 |
SYM |
denotes |
′ |
T13892 |
55691-55692 |
-RRB- |
denotes |
) |
T13893 |
55692-55694 |
, |
denotes |
, |
T13894 |
55694-55697 |
CD |
denotes |
600 |
T13895 |
55700-55701 |
. |
denotes |
. |
T13896 |
55701-55805 |
sentence |
denotes |
TgCN12-itTA: htTA1 (5′- AGAGCAAAGTCATCAACTCTG-3′) and htTA2 (5′- GTGAGAGCCAGACTCACATTTCA-3′), 1,000 bp. |
T13897 |
55702-55708 |
NN |
denotes |
TgCN12 |
T13898 |
55709-55713 |
NN |
denotes |
itTA |
T13899 |
55708-55709 |
HYPH |
denotes |
- |
T13900 |
55713-55715 |
: |
denotes |
: |
T13901 |
55715-55720 |
NN |
denotes |
htTA1 |
T13902 |
55802-55804 |
NN |
denotes |
bp |
T13903 |
55721-55722 |
-LRB- |
denotes |
( |
T13904 |
55726-55747 |
NN |
denotes |
AGAGCAAAGTCATCAACTCTG |
T13905 |
55722-55723 |
CD |
denotes |
5 |
T13906 |
55723-55724 |
SYM |
denotes |
′ |
T13907 |
55724-55725 |
HYPH |
denotes |
- |
T13908 |
55747-55748 |
HYPH |
denotes |
- |
T13909 |
55748-55749 |
CD |
denotes |
3 |
T13910 |
55749-55750 |
SYM |
denotes |
′ |
T13911 |
55750-55751 |
-RRB- |
denotes |
) |
T13912 |
55752-55755 |
CC |
denotes |
and |
T13913 |
55756-55761 |
NN |
denotes |
htTA2 |
T13914 |
55762-55763 |
-LRB- |
denotes |
( |
T13915 |
55767-55790 |
NN |
denotes |
GTGAGAGCCAGACTCACATTTCA |
T13916 |
55763-55764 |
CD |
denotes |
5 |
T13917 |
55764-55765 |
SYM |
denotes |
′ |
T13918 |
55765-55766 |
HYPH |
denotes |
- |
T13919 |
55790-55791 |
HYPH |
denotes |
- |
T13920 |
55791-55792 |
CD |
denotes |
3 |
T13921 |
55792-55793 |
SYM |
denotes |
′ |
T13922 |
55793-55794 |
-RRB- |
denotes |
) |
T13923 |
55794-55796 |
, |
denotes |
, |
T13924 |
55796-55801 |
CD |
denotes |
1,000 |
T13925 |
55804-55805 |
. |
denotes |
. |
T13970 |
55807-55815 |
NNP |
denotes |
Southern |
T13971 |
55816-55820 |
NN |
denotes |
blot |
T13972 |
55821-55829 |
NN |
denotes |
analysis |
T13973 |
55829-56022 |
sentence |
denotes |
Genomic DNA from mouse-tail/liver was digested with restriction enzyme BglII (NEB), and the Southern blot was done with a 320-bp probe (“integ”) obtained by PCR detecting the αCaMKII promoter. |
T13974 |
55830-55837 |
JJ |
denotes |
Genomic |
T13975 |
55838-55841 |
NN |
denotes |
DNA |
T13976 |
55868-55876 |
VBN |
denotes |
digested |
T13977 |
55842-55846 |
IN |
denotes |
from |
T13978 |
55847-55852 |
NN |
denotes |
mouse |
T13979 |
55853-55857 |
NN |
denotes |
tail |
T13980 |
55852-55853 |
HYPH |
denotes |
- |
T13981 |
55857-55858 |
HYPH |
denotes |
/ |
T13982 |
55858-55863 |
NN |
denotes |
liver |
T13983 |
55864-55867 |
VBD |
denotes |
was |
T13984 |
55877-55881 |
IN |
denotes |
with |
T13985 |
55882-55893 |
NN |
denotes |
restriction |
T13986 |
55901-55906 |
NN |
denotes |
BglII |
T13987 |
55894-55900 |
NN |
denotes |
enzyme |
T13988 |
55907-55908 |
-LRB- |
denotes |
( |
T13989 |
55908-55911 |
NN |
denotes |
NEB |
T13990 |
55911-55912 |
-RRB- |
denotes |
) |
T13991 |
55912-55914 |
, |
denotes |
, |
T13992 |
55914-55917 |
CC |
denotes |
and |
T13993 |
55918-55921 |
DT |
denotes |
the |
T13994 |
55931-55935 |
NN |
denotes |
blot |
T13995 |
55922-55930 |
NNP |
denotes |
Southern |
T13996 |
55940-55944 |
VBN |
denotes |
done |
T13997 |
55936-55939 |
VBD |
denotes |
was |
T13998 |
55945-55949 |
IN |
denotes |
with |
T13999 |
55950-55951 |
DT |
denotes |
a |
T14000 |
55959-55964 |
NN |
denotes |
probe |
T14001 |
55952-55955 |
CD |
denotes |
320 |
T14002 |
55956-55958 |
NN |
denotes |
bp |
T14003 |
55955-55956 |
HYPH |
denotes |
- |
T14004 |
55965-55966 |
-LRB- |
denotes |
( |
T14005 |
55967-55972 |
NN |
denotes |
integ |
T14006 |
55966-55967 |
`` |
denotes |
“ |
T14007 |
55972-55973 |
'' |
denotes |
” |
T14008 |
55973-55974 |
-RRB- |
denotes |
) |
T14009 |
55975-55983 |
VBN |
denotes |
obtained |
T14010 |
55984-55986 |
IN |
denotes |
by |
T14011 |
55987-55990 |
NN |
denotes |
PCR |
T14012 |
55991-56000 |
VBG |
denotes |
detecting |
T14013 |
56001-56004 |
DT |
denotes |
the |
T14014 |
56013-56021 |
NN |
denotes |
promoter |
T14015 |
56005-56012 |
NN |
denotes |
αCaMKII |
T14016 |
56021-56022 |
. |
denotes |
. |
T14048 |
56024-56038 |
NN |
denotes |
Histochemistry |
T14049 |
56038-56601 |
sentence |
denotes |
Histochemistry was performed as described previously [89], with the following exceptions: Coronal 70- to 100-μm vibratome slices were used for immunohistochemistry with GluR-B (1:60, polyclonal; Chemicon, Temecula, California, United States), GFP (1:8,000, polyclonal; MobiTech, Göttingen, Germany), and Cre (1:8,000, polyclonal; BAbCO, Berkeley, California, United States) primary antibodies, and FITC-coupled (1:200; Dianova, Hamburg, Germany) and peroxidase-coupled (1:600; Vector, Burlingame, California, United States) secondary goat anti-rabbit antibodies. |
T14050 |
56039-56053 |
NN |
denotes |
Histochemistry |
T14051 |
56058-56067 |
VBN |
denotes |
performed |
T14052 |
56054-56057 |
VBD |
denotes |
was |
T14053 |
56173-56177 |
VBN |
denotes |
used |
T14054 |
56068-56070 |
IN |
denotes |
as |
T14055 |
56071-56080 |
VBN |
denotes |
described |
T14056 |
56081-56091 |
RB |
denotes |
previously |
T14057 |
56092-56093 |
-LRB- |
denotes |
[ |
T14058 |
56093-56095 |
CD |
denotes |
89 |
T14059 |
56095-56096 |
-RRB- |
denotes |
] |
T14060 |
56096-56098 |
, |
denotes |
, |
T14061 |
56098-56102 |
IN |
denotes |
with |
T14062 |
56103-56106 |
DT |
denotes |
the |
T14063 |
56117-56127 |
NNS |
denotes |
exceptions |
T14064 |
56107-56116 |
VBG |
denotes |
following |
T14065 |
56127-56129 |
: |
denotes |
: |
T14066 |
56129-56136 |
JJ |
denotes |
Coronal |
T14067 |
56161-56167 |
NNS |
denotes |
slices |
T14068 |
56137-56139 |
CD |
denotes |
70 |
T14069 |
56144-56147 |
CD |
denotes |
100 |
T14070 |
56139-56140 |
HYPH |
denotes |
- |
T14071 |
56141-56143 |
IN |
denotes |
to |
T14072 |
56148-56150 |
NN |
denotes |
μm |
T14073 |
56147-56148 |
HYPH |
denotes |
- |
T14074 |
56151-56160 |
NN |
denotes |
vibratome |
T14075 |
56168-56172 |
VBD |
denotes |
were |
T14076 |
56178-56181 |
IN |
denotes |
for |
T14077 |
56182-56202 |
NN |
denotes |
immunohistochemistry |
T14078 |
56203-56207 |
IN |
denotes |
with |
T14079 |
56208-56212 |
NN |
denotes |
GluR |
T14080 |
56213-56214 |
NN |
denotes |
B |
T14081 |
56212-56213 |
HYPH |
denotes |
- |
T14082 |
56421-56431 |
NNS |
denotes |
antibodies |
T14083 |
56215-56216 |
-LRB- |
denotes |
( |
T14084 |
56234-56242 |
NNP |
denotes |
Chemicon |
T14085 |
56216-56217 |
CD |
denotes |
1 |
T14086 |
56217-56218 |
SYM |
denotes |
: |
T14087 |
56218-56220 |
CD |
denotes |
60 |
T14088 |
56220-56222 |
, |
denotes |
, |
T14089 |
56222-56232 |
JJ |
denotes |
polyclonal |
T14090 |
56232-56233 |
: |
denotes |
; |
T14091 |
56242-56244 |
, |
denotes |
, |
T14092 |
56244-56252 |
NNP |
denotes |
Temecula |
T14093 |
56252-56254 |
, |
denotes |
, |
T14094 |
56254-56264 |
NNP |
denotes |
California |
T14095 |
56264-56266 |
, |
denotes |
, |
T14096 |
56266-56272 |
NNP |
denotes |
United |
T14097 |
56273-56279 |
NNP |
denotes |
States |
T14098 |
56279-56280 |
-RRB- |
denotes |
) |
T14099 |
56280-56282 |
, |
denotes |
, |
T14100 |
56282-56285 |
NN |
denotes |
GFP |
T14101 |
56286-56287 |
-LRB- |
denotes |
( |
T14102 |
56308-56316 |
NNP |
denotes |
MobiTech |
T14103 |
56287-56288 |
CD |
denotes |
1 |
T14104 |
56288-56289 |
SYM |
denotes |
: |
T14105 |
56289-56294 |
CD |
denotes |
8,000 |
T14106 |
56294-56296 |
, |
denotes |
, |
T14107 |
56296-56306 |
JJ |
denotes |
polyclonal |
T14108 |
56306-56307 |
: |
denotes |
; |
T14109 |
56316-56318 |
, |
denotes |
, |
T14110 |
56318-56327 |
NNP |
denotes |
Göttingen |
T14111 |
56327-56329 |
, |
denotes |
, |
T14112 |
56329-56336 |
NNP |
denotes |
Germany |
T14113 |
56336-56337 |
-RRB- |
denotes |
) |
T14114 |
56337-56339 |
, |
denotes |
, |
T14115 |
56339-56342 |
CC |
denotes |
and |
T14116 |
56343-56346 |
NN |
denotes |
Cre |
T14117 |
56347-56348 |
-LRB- |
denotes |
( |
T14118 |
56369-56374 |
NNP |
denotes |
BAbCO |
T14119 |
56348-56349 |
CD |
denotes |
1 |
T14120 |
56349-56350 |
SYM |
denotes |
: |
T14121 |
56350-56355 |
CD |
denotes |
8,000 |
T14122 |
56355-56357 |
, |
denotes |
, |
T14123 |
56357-56367 |
JJ |
denotes |
polyclonal |
T14124 |
56367-56368 |
: |
denotes |
; |
T14125 |
56374-56376 |
, |
denotes |
, |
T14126 |
56376-56384 |
NNP |
denotes |
Berkeley |
T14127 |
56384-56386 |
, |
denotes |
, |
T14128 |
56386-56396 |
NNP |
denotes |
California |
T14129 |
56396-56398 |
, |
denotes |
, |
T14130 |
56398-56404 |
NNP |
denotes |
United |
T14131 |
56405-56411 |
NNP |
denotes |
States |
T14132 |
56411-56412 |
-RRB- |
denotes |
) |
T14133 |
56413-56420 |
JJ |
denotes |
primary |
T14134 |
56431-56433 |
, |
denotes |
, |
T14135 |
56433-56436 |
CC |
denotes |
and |
T14136 |
56437-56441 |
NN |
denotes |
FITC |
T14137 |
56442-56449 |
VBN |
denotes |
coupled |
T14138 |
56441-56442 |
HYPH |
denotes |
- |
T14139 |
56590-56600 |
NNS |
denotes |
antibodies |
T14140 |
56450-56451 |
-LRB- |
denotes |
( |
T14141 |
56458-56465 |
NNP |
denotes |
Dianova |
T14142 |
56451-56452 |
CD |
denotes |
1 |
T14143 |
56452-56453 |
SYM |
denotes |
: |
T14144 |
56453-56456 |
CD |
denotes |
200 |
T14145 |
56456-56457 |
: |
denotes |
; |
T14146 |
56465-56467 |
, |
denotes |
, |
T14147 |
56467-56474 |
NNP |
denotes |
Hamburg |
T14148 |
56474-56476 |
, |
denotes |
, |
T14149 |
56476-56483 |
NNP |
denotes |
Germany |
T14150 |
56483-56484 |
-RRB- |
denotes |
) |
T14151 |
56485-56488 |
CC |
denotes |
and |
T14152 |
56489-56499 |
NN |
denotes |
peroxidase |
T14153 |
56500-56507 |
VBN |
denotes |
coupled |
T14154 |
56499-56500 |
HYPH |
denotes |
- |
T14155 |
56508-56509 |
-LRB- |
denotes |
( |
T14156 |
56516-56522 |
NNP |
denotes |
Vector |
T14157 |
56509-56510 |
CD |
denotes |
1 |
T14158 |
56510-56511 |
SYM |
denotes |
: |
T14159 |
56511-56514 |
CD |
denotes |
600 |
T14160 |
56514-56515 |
: |
denotes |
; |
T14161 |
56522-56524 |
, |
denotes |
, |
T14162 |
56524-56534 |
NNP |
denotes |
Burlingame |
T14163 |
56534-56536 |
, |
denotes |
, |
T14164 |
56536-56546 |
NNP |
denotes |
California |
T14165 |
56546-56548 |
, |
denotes |
, |
T14166 |
56548-56554 |
NNP |
denotes |
United |
T14167 |
56555-56561 |
NNP |
denotes |
States |
T14168 |
56561-56562 |
-RRB- |
denotes |
) |
T14169 |
56563-56572 |
JJ |
denotes |
secondary |
T14170 |
56573-56577 |
NN |
denotes |
goat |
T14171 |
56578-56589 |
JJ |
denotes |
anti-rabbit |
T14172 |
56600-56601 |
. |
denotes |
. |
T14173 |
56601-56760 |
sentence |
denotes |
The main olfactory epithelium was obtained via cryostat sectioning, and immunohistochemistry was performed (primary antibody Cre, 1:5,000, polyclonal; BAbCO). |
T14174 |
56602-56605 |
DT |
denotes |
The |
T14175 |
56621-56631 |
NN |
denotes |
epithelium |
T14176 |
56606-56610 |
JJ |
denotes |
main |
T14177 |
56611-56620 |
JJ |
denotes |
olfactory |
T14178 |
56636-56644 |
VBN |
denotes |
obtained |
T14179 |
56632-56635 |
VBD |
denotes |
was |
T14180 |
56645-56648 |
IN |
denotes |
via |
T14181 |
56649-56657 |
NN |
denotes |
cryostat |
T14182 |
56658-56668 |
NN |
denotes |
sectioning |
T14183 |
56668-56670 |
, |
denotes |
, |
T14184 |
56670-56673 |
CC |
denotes |
and |
T14185 |
56674-56694 |
NN |
denotes |
immunohistochemistry |
T14186 |
56699-56708 |
VBN |
denotes |
performed |
T14187 |
56695-56698 |
VBD |
denotes |
was |
T14188 |
56709-56710 |
-LRB- |
denotes |
( |
T14189 |
56753-56758 |
NN |
denotes |
BAbCO |
T14190 |
56710-56717 |
JJ |
denotes |
primary |
T14191 |
56727-56730 |
NN |
denotes |
Cre |
T14192 |
56718-56726 |
NN |
denotes |
antibody |
T14193 |
56732-56733 |
CD |
denotes |
1 |
T14194 |
56730-56732 |
, |
denotes |
, |
T14195 |
56733-56734 |
SYM |
denotes |
: |
T14196 |
56734-56739 |
CD |
denotes |
5,000 |
T14197 |
56739-56741 |
, |
denotes |
, |
T14198 |
56741-56751 |
JJ |
denotes |
polyclonal |
T14199 |
56751-56752 |
: |
denotes |
; |
T14200 |
56758-56759 |
-RRB- |
denotes |
) |
T14201 |
56759-56760 |
. |
denotes |
. |
T14202 |
56760-56808 |
sentence |
denotes |
X-gal staining was performed as described [89]. |
T14203 |
56761-56762 |
NN |
denotes |
X |
T14204 |
56763-56766 |
NN |
denotes |
gal |
T14205 |
56762-56763 |
HYPH |
denotes |
- |
T14206 |
56767-56775 |
NN |
denotes |
staining |
T14207 |
56780-56789 |
VBN |
denotes |
performed |
T14208 |
56776-56779 |
VBD |
denotes |
was |
T14209 |
56790-56792 |
IN |
denotes |
as |
T14210 |
56793-56802 |
VBN |
denotes |
described |
T14211 |
56803-56804 |
-LRB- |
denotes |
[ |
T14212 |
56804-56806 |
CD |
denotes |
89 |
T14213 |
56806-56807 |
-RRB- |
denotes |
] |
T14214 |
56807-56808 |
. |
denotes |
. |
T14252 |
56810-56820 |
NN |
denotes |
Immunoblot |
T14253 |
56821-56829 |
NN |
denotes |
analysis |
T14254 |
56829-56938 |
sentence |
denotes |
Mouse brains were removed, and the hippocampus, olfactory bulb, and remaining forebrain areas were isolated. |
T14255 |
56830-56835 |
NN |
denotes |
Mouse |
T14256 |
56836-56842 |
NNS |
denotes |
brains |
T14257 |
56848-56855 |
VBN |
denotes |
removed |
T14258 |
56843-56847 |
VBD |
denotes |
were |
T14259 |
56855-56857 |
, |
denotes |
, |
T14260 |
56857-56860 |
CC |
denotes |
and |
T14261 |
56861-56864 |
DT |
denotes |
the |
T14262 |
56865-56876 |
NN |
denotes |
hippocampus |
T14263 |
56929-56937 |
VBN |
denotes |
isolated |
T14264 |
56876-56878 |
, |
denotes |
, |
T14265 |
56878-56887 |
JJ |
denotes |
olfactory |
T14266 |
56888-56892 |
NN |
denotes |
bulb |
T14267 |
56892-56894 |
, |
denotes |
, |
T14268 |
56894-56897 |
CC |
denotes |
and |
T14269 |
56898-56907 |
VBG |
denotes |
remaining |
T14270 |
56918-56923 |
NNS |
denotes |
areas |
T14271 |
56908-56917 |
NN |
denotes |
forebrain |
T14272 |
56924-56928 |
VBD |
denotes |
were |
T14273 |
56937-56938 |
. |
denotes |
. |
T14274 |
56938-57016 |
sentence |
denotes |
Total protein was prepared, and immunoblots were performed as described [87]. |
T14275 |
56939-56944 |
JJ |
denotes |
Total |
T14276 |
56945-56952 |
NN |
denotes |
protein |
T14277 |
56957-56965 |
VBN |
denotes |
prepared |
T14278 |
56953-56956 |
VBD |
denotes |
was |
T14279 |
56965-56967 |
, |
denotes |
, |
T14280 |
56967-56970 |
CC |
denotes |
and |
T14281 |
56971-56982 |
NNS |
denotes |
immunoblots |
T14282 |
56988-56997 |
VBN |
denotes |
performed |
T14283 |
56983-56987 |
VBD |
denotes |
were |
T14284 |
56998-57000 |
IN |
denotes |
as |
T14285 |
57001-57010 |
VBN |
denotes |
described |
T14286 |
57011-57012 |
-LRB- |
denotes |
[ |
T14287 |
57012-57014 |
CD |
denotes |
87 |
T14288 |
57014-57015 |
-RRB- |
denotes |
] |
T14289 |
57015-57016 |
. |
denotes |
. |
T14290 |
57016-57264 |
sentence |
denotes |
Antibodies used were against GluR-B (1:800, monoclonal; Chemicon), β-actin (1:40,000, monoclonal; Sigma, St. Louis, Missouri, United States) as an internal standard, and secondary goat anti-rabbit and goat anti-mouse antibodies (Vector, 1:15,000). |
T14291 |
57017-57027 |
NNS |
denotes |
Antibodies |
T14292 |
57033-57037 |
VBD |
denotes |
were |
T14293 |
57028-57032 |
VBN |
denotes |
used |
T14294 |
57038-57045 |
IN |
denotes |
against |
T14295 |
57046-57050 |
NN |
denotes |
GluR |
T14296 |
57051-57052 |
NN |
denotes |
B |
T14297 |
57050-57051 |
HYPH |
denotes |
- |
T14298 |
57053-57054 |
-LRB- |
denotes |
( |
T14299 |
57073-57081 |
NNP |
denotes |
Chemicon |
T14300 |
57054-57055 |
CD |
denotes |
1 |
T14301 |
57061-57071 |
JJ |
denotes |
monoclonal |
T14302 |
57055-57056 |
SYM |
denotes |
: |
T14303 |
57056-57059 |
CD |
denotes |
800 |
T14304 |
57059-57061 |
, |
denotes |
, |
T14305 |
57071-57072 |
: |
denotes |
; |
T14306 |
57081-57082 |
-RRB- |
denotes |
) |
T14307 |
57082-57084 |
, |
denotes |
, |
T14308 |
57084-57085 |
NN |
denotes |
β |
T14309 |
57086-57091 |
NN |
denotes |
actin |
T14310 |
57085-57086 |
HYPH |
denotes |
- |
T14311 |
57092-57093 |
-LRB- |
denotes |
( |
T14312 |
57115-57120 |
NNP |
denotes |
Sigma |
T14313 |
57093-57094 |
CD |
denotes |
1 |
T14314 |
57103-57113 |
JJ |
denotes |
monoclonal |
T14315 |
57094-57095 |
SYM |
denotes |
: |
T14316 |
57095-57101 |
CD |
denotes |
40,000 |
T14317 |
57101-57103 |
, |
denotes |
, |
T14318 |
57113-57114 |
: |
denotes |
; |
T14319 |
57120-57122 |
, |
denotes |
, |
T14320 |
57122-57125 |
NNP |
denotes |
St. |
T14321 |
57126-57131 |
NNP |
denotes |
Louis |
T14322 |
57131-57133 |
, |
denotes |
, |
T14323 |
57133-57141 |
NNP |
denotes |
Missouri |
T14324 |
57141-57143 |
, |
denotes |
, |
T14325 |
57143-57149 |
NNP |
denotes |
United |
T14326 |
57150-57156 |
NNP |
denotes |
States |
T14327 |
57156-57157 |
-RRB- |
denotes |
) |
T14328 |
57158-57160 |
IN |
denotes |
as |
T14329 |
57161-57163 |
DT |
denotes |
an |
T14330 |
57173-57181 |
NN |
denotes |
standard |
T14331 |
57164-57172 |
JJ |
denotes |
internal |
T14332 |
57181-57183 |
, |
denotes |
, |
T14333 |
57183-57186 |
CC |
denotes |
and |
T14334 |
57187-57196 |
JJ |
denotes |
secondary |
T14335 |
57234-57244 |
NNS |
denotes |
antibodies |
T14336 |
57197-57201 |
NN |
denotes |
goat |
T14337 |
57202-57213 |
JJ |
denotes |
anti-rabbit |
T14338 |
57214-57217 |
CC |
denotes |
and |
T14339 |
57218-57222 |
NN |
denotes |
goat |
T14340 |
57223-57233 |
JJ |
denotes |
anti-mouse |
T14341 |
57245-57246 |
-LRB- |
denotes |
( |
T14342 |
57254-57255 |
CD |
denotes |
1 |
T14343 |
57246-57252 |
NNP |
denotes |
Vector |
T14344 |
57252-57254 |
, |
denotes |
, |
T14345 |
57255-57256 |
SYM |
denotes |
: |
T14346 |
57256-57262 |
CD |
denotes |
15,000 |
T14347 |
57262-57263 |
-RRB- |
denotes |
) |
T14348 |
57263-57264 |
. |
denotes |
. |
T14349 |
57264-57422 |
sentence |
denotes |
Immunoreactivity was detected with ECLplus (Amersham, Little Chalfont, United Kingdom), and immunoblots were scanned and quantitatively analyzed with ImageJ. |
T14350 |
57265-57281 |
NN |
denotes |
Immunoreactivity |
T14351 |
57286-57294 |
VBN |
denotes |
detected |
T14352 |
57282-57285 |
VBD |
denotes |
was |
T14353 |
57295-57299 |
IN |
denotes |
with |
T14354 |
57300-57307 |
NNP |
denotes |
ECLplus |
T14355 |
57308-57309 |
-LRB- |
denotes |
( |
T14356 |
57309-57317 |
NNP |
denotes |
Amersham |
T14357 |
57317-57319 |
, |
denotes |
, |
T14358 |
57319-57325 |
NNP |
denotes |
Little |
T14359 |
57326-57334 |
NNP |
denotes |
Chalfont |
T14360 |
57334-57336 |
, |
denotes |
, |
T14361 |
57336-57342 |
NNP |
denotes |
United |
T14362 |
57343-57350 |
NNP |
denotes |
Kingdom |
T14363 |
57350-57351 |
-RRB- |
denotes |
) |
T14364 |
57351-57353 |
, |
denotes |
, |
T14365 |
57353-57356 |
CC |
denotes |
and |
T14366 |
57357-57368 |
NNS |
denotes |
immunoblots |
T14367 |
57374-57381 |
VBN |
denotes |
scanned |
T14368 |
57369-57373 |
VBD |
denotes |
were |
T14369 |
57382-57385 |
CC |
denotes |
and |
T14370 |
57386-57400 |
RB |
denotes |
quantitatively |
T14371 |
57401-57409 |
VBN |
denotes |
analyzed |
T14372 |
57410-57414 |
IN |
denotes |
with |
T14373 |
57415-57421 |
NNP |
denotes |
ImageJ |
T14374 |
57421-57422 |
. |
denotes |
. |
T14415 |
57424-57434 |
JJ |
denotes |
Behavioral |
T14416 |
57435-57443 |
NN |
denotes |
analysis |
T14417 |
57445-57453 |
NNS |
denotes |
Subjects |
T14418 |
57443-57445 |
: |
denotes |
: |
T14419 |
57453-57526 |
sentence |
denotes |
All mice were four to six weeks old at the beginning of the experiments. |
T14420 |
57454-57457 |
DT |
denotes |
All |
T14421 |
57458-57462 |
NNS |
denotes |
mice |
T14422 |
57463-57467 |
VBD |
denotes |
were |
T14423 |
57468-57472 |
CD |
denotes |
four |
T14424 |
57476-57479 |
CD |
denotes |
six |
T14425 |
57473-57475 |
IN |
denotes |
to |
T14426 |
57480-57485 |
NNS |
denotes |
weeks |
T14427 |
57486-57489 |
JJ |
denotes |
old |
T14428 |
57490-57492 |
IN |
denotes |
at |
T14429 |
57493-57496 |
DT |
denotes |
the |
T14430 |
57497-57506 |
NN |
denotes |
beginning |
T14431 |
57507-57509 |
IN |
denotes |
of |
T14432 |
57510-57513 |
DT |
denotes |
the |
T14433 |
57514-57525 |
NNS |
denotes |
experiments |
T14434 |
57525-57526 |
. |
denotes |
. |
T14435 |
57526-57654 |
sentence |
denotes |
Subjects were maintained on a 12-h light-dark cycle in isolated cages in a temperature and humidity-controlled animal facility. |
T14436 |
57527-57535 |
NNS |
denotes |
Subjects |
T14437 |
57541-57551 |
VBN |
denotes |
maintained |
T14438 |
57536-57540 |
VBD |
denotes |
were |
T14439 |
57552-57554 |
IN |
denotes |
on |
T14440 |
57555-57556 |
DT |
denotes |
a |
T14441 |
57573-57578 |
NN |
denotes |
cycle |
T14442 |
57557-57559 |
CD |
denotes |
12 |
T14443 |
57560-57561 |
NN |
denotes |
h |
T14444 |
57559-57560 |
HYPH |
denotes |
- |
T14445 |
57562-57567 |
NN |
denotes |
light |
T14446 |
57568-57572 |
NN |
denotes |
dark |
T14447 |
57567-57568 |
HYPH |
denotes |
- |
T14448 |
57579-57581 |
IN |
denotes |
in |
T14449 |
57582-57590 |
VBN |
denotes |
isolated |
T14450 |
57591-57596 |
NNS |
denotes |
cages |
T14451 |
57597-57599 |
IN |
denotes |
in |
T14452 |
57600-57601 |
DT |
denotes |
a |
T14453 |
57645-57653 |
NN |
denotes |
facility |
T14454 |
57602-57613 |
NN |
denotes |
temperature |
T14455 |
57627-57637 |
VBN |
denotes |
controlled |
T14456 |
57614-57617 |
CC |
denotes |
and |
T14457 |
57618-57626 |
NN |
denotes |
humidity |
T14458 |
57626-57627 |
HYPH |
denotes |
- |
T14459 |
57638-57644 |
NN |
denotes |
animal |
T14460 |
57653-57654 |
. |
denotes |
. |
T14461 |
57654-57708 |
sentence |
denotes |
All behavioral training was conducted during daytime. |
T14462 |
57655-57658 |
DT |
denotes |
All |
T14463 |
57670-57678 |
NN |
denotes |
training |
T14464 |
57659-57669 |
JJ |
denotes |
behavioral |
T14465 |
57683-57692 |
VBN |
denotes |
conducted |
T14466 |
57679-57682 |
VBD |
denotes |
was |
T14467 |
57693-57699 |
IN |
denotes |
during |
T14468 |
57700-57707 |
NN |
denotes |
daytime |
T14469 |
57707-57708 |
. |
denotes |
. |
T14470 |
57708-57866 |
sentence |
denotes |
During the training period, animals were kept on free food but on a water-restriction schedule designed to keep them at > 85% of their free food body weight. |
T14471 |
57709-57715 |
IN |
denotes |
During |
T14472 |
57750-57754 |
VBN |
denotes |
kept |
T14473 |
57716-57719 |
DT |
denotes |
the |
T14474 |
57729-57735 |
NN |
denotes |
period |
T14475 |
57720-57728 |
NN |
denotes |
training |
T14476 |
57735-57737 |
, |
denotes |
, |
T14477 |
57737-57744 |
NNS |
denotes |
animals |
T14478 |
57745-57749 |
VBD |
denotes |
were |
T14479 |
57755-57757 |
IN |
denotes |
on |
T14480 |
57758-57762 |
JJ |
denotes |
free |
T14481 |
57763-57767 |
NN |
denotes |
food |
T14482 |
57768-57771 |
CC |
denotes |
but |
T14483 |
57772-57774 |
IN |
denotes |
on |
T14484 |
57775-57776 |
DT |
denotes |
a |
T14485 |
57795-57803 |
NN |
denotes |
schedule |
T14486 |
57777-57782 |
NN |
denotes |
water |
T14487 |
57783-57794 |
NN |
denotes |
restriction |
T14488 |
57782-57783 |
HYPH |
denotes |
- |
T14489 |
57804-57812 |
VBN |
denotes |
designed |
T14490 |
57813-57815 |
TO |
denotes |
to |
T14491 |
57816-57820 |
VB |
denotes |
keep |
T14492 |
57821-57825 |
PRP |
denotes |
them |
T14493 |
57826-57828 |
IN |
denotes |
at |
T14494 |
57829-57830 |
SYM |
denotes |
> |
T14495 |
57831-57833 |
CD |
denotes |
85 |
T14496 |
57833-57834 |
NN |
denotes |
% |
T14497 |
57835-57837 |
IN |
denotes |
of |
T14498 |
57838-57843 |
PRP$ |
denotes |
their |
T14499 |
57859-57865 |
NN |
denotes |
weight |
T14500 |
57844-57848 |
JJ |
denotes |
free |
T14501 |
57849-57853 |
NN |
denotes |
food |
T14502 |
57854-57858 |
NN |
denotes |
body |
T14503 |
57865-57866 |
. |
denotes |
. |
T14504 |
57866-57923 |
sentence |
denotes |
Continuous water restriction was never longer than 12 h. |
T14505 |
57867-57877 |
JJ |
denotes |
Continuous |
T14506 |
57884-57895 |
NN |
denotes |
restriction |
T14507 |
57878-57883 |
NN |
denotes |
water |
T14508 |
57896-57899 |
VBD |
denotes |
was |
T14509 |
57900-57905 |
RB |
denotes |
never |
T14510 |
57906-57912 |
RBR |
denotes |
longer |
T14511 |
57913-57917 |
IN |
denotes |
than |
T14512 |
57918-57920 |
CD |
denotes |
12 |
T14513 |
57921-57922 |
NN |
denotes |
h |
T14514 |
57922-57923 |
. |
denotes |
. |
T14515 |
57923-58034 |
sentence |
denotes |
All animal care and procedures were in accordance with the animal ethics guidelines of the Max-Planck Society. |
T14516 |
57924-57927 |
DT |
denotes |
All |
T14517 |
57935-57939 |
NN |
denotes |
care |
T14518 |
57928-57934 |
NN |
denotes |
animal |
T14519 |
57955-57959 |
VBD |
denotes |
were |
T14520 |
57940-57943 |
CC |
denotes |
and |
T14521 |
57944-57954 |
NNS |
denotes |
procedures |
T14522 |
57960-57962 |
IN |
denotes |
in |
T14523 |
57963-57973 |
NN |
denotes |
accordance |
T14524 |
57974-57978 |
IN |
denotes |
with |
T14525 |
57979-57982 |
DT |
denotes |
the |
T14526 |
57997-58007 |
NNS |
denotes |
guidelines |
T14527 |
57983-57989 |
NN |
denotes |
animal |
T14528 |
57990-57996 |
NN |
denotes |
ethics |
T14529 |
58008-58010 |
IN |
denotes |
of |
T14530 |
58011-58014 |
DT |
denotes |
the |
T14531 |
58026-58033 |
NNP |
denotes |
Society |
T14532 |
58015-58018 |
NNP |
denotes |
Max |
T14533 |
58019-58025 |
NNP |
denotes |
Planck |
T14534 |
58018-58019 |
HYPH |
denotes |
- |
T14535 |
58033-58034 |
. |
denotes |
. |
T14651 |
58441-58443 |
IN |
denotes |
In |
T14572 |
58036-58045 |
NN |
denotes |
Apparatus |
T14573 |
58045-58378 |
sentence |
denotes |
All olfactory discrimination experiments were performed using three modified eight- channel olfactometers ([61], Knosys, Bethesda, Maryland, United States of America) operated by custom-written software in Igor (Wave Metrics, Lake Oswego, Oregon, United States of America) on Pentium I, II, and III PCs running Microsoft Windows 98. |
T14574 |
58046-58049 |
DT |
denotes |
All |
T14575 |
58075-58086 |
NNS |
denotes |
experiments |
T14576 |
58050-58059 |
JJ |
denotes |
olfactory |
T14577 |
58060-58074 |
NN |
denotes |
discrimination |
T14578 |
58092-58101 |
VBN |
denotes |
performed |
T14579 |
58087-58091 |
VBD |
denotes |
were |
T14580 |
58102-58107 |
VBG |
denotes |
using |
T14581 |
58108-58113 |
CD |
denotes |
three |
T14582 |
58138-58151 |
NNS |
denotes |
olfactometers |
T14583 |
58114-58122 |
VBN |
denotes |
modified |
T14584 |
58123-58128 |
CD |
denotes |
eight |
T14585 |
58130-58137 |
NN |
denotes |
channel |
T14586 |
58128-58129 |
HYPH |
denotes |
- |
T14587 |
58152-58153 |
-LRB- |
denotes |
( |
T14588 |
58159-58165 |
NNP |
denotes |
Knosys |
T14589 |
58153-58154 |
-LRB- |
denotes |
[ |
T14590 |
58154-58156 |
CD |
denotes |
61 |
T14591 |
58156-58157 |
-RRB- |
denotes |
] |
T14592 |
58157-58159 |
, |
denotes |
, |
T14593 |
58165-58167 |
, |
denotes |
, |
T14594 |
58167-58175 |
NNP |
denotes |
Bethesda |
T14595 |
58175-58177 |
, |
denotes |
, |
T14596 |
58177-58185 |
NNP |
denotes |
Maryland |
T14597 |
58185-58187 |
, |
denotes |
, |
T14598 |
58187-58193 |
NNP |
denotes |
United |
T14599 |
58194-58200 |
NNP |
denotes |
States |
T14600 |
58201-58203 |
IN |
denotes |
of |
T14601 |
58204-58211 |
NNP |
denotes |
America |
T14602 |
58211-58212 |
-RRB- |
denotes |
) |
T14603 |
58213-58221 |
VBN |
denotes |
operated |
T14604 |
58222-58224 |
IN |
denotes |
by |
T14605 |
58225-58231 |
JJ |
denotes |
custom |
T14606 |
58232-58239 |
VBN |
denotes |
written |
T14607 |
58231-58232 |
HYPH |
denotes |
- |
T14608 |
58240-58248 |
NN |
denotes |
software |
T14609 |
58249-58251 |
IN |
denotes |
in |
T14610 |
58252-58256 |
NNP |
denotes |
Igor |
T14611 |
58257-58258 |
-LRB- |
denotes |
( |
T14612 |
58263-58270 |
NNP |
denotes |
Metrics |
T14613 |
58258-58262 |
NNP |
denotes |
Wave |
T14614 |
58270-58272 |
, |
denotes |
, |
T14615 |
58272-58276 |
NNP |
denotes |
Lake |
T14616 |
58277-58283 |
NNP |
denotes |
Oswego |
T14617 |
58283-58285 |
, |
denotes |
, |
T14618 |
58285-58291 |
NNP |
denotes |
Oregon |
T14619 |
58291-58293 |
, |
denotes |
, |
T14620 |
58293-58299 |
NNP |
denotes |
United |
T14621 |
58300-58306 |
NNP |
denotes |
States |
T14622 |
58307-58309 |
IN |
denotes |
of |
T14623 |
58310-58317 |
NNP |
denotes |
America |
T14624 |
58317-58318 |
-RRB- |
denotes |
) |
T14625 |
58319-58321 |
IN |
denotes |
on |
T14626 |
58322-58329 |
NN |
denotes |
Pentium |
T14627 |
58330-58331 |
CD |
denotes |
I |
T14628 |
58345-58348 |
NNS |
denotes |
PCs |
T14629 |
58331-58333 |
, |
denotes |
, |
T14630 |
58333-58335 |
CD |
denotes |
II |
T14631 |
58335-58337 |
, |
denotes |
, |
T14632 |
58337-58340 |
CC |
denotes |
and |
T14633 |
58341-58344 |
CD |
denotes |
III |
T14634 |
58349-58356 |
VBG |
denotes |
running |
T14635 |
58357-58366 |
NNP |
denotes |
Microsoft |
T14636 |
58367-58374 |
NNP |
denotes |
Windows |
T14637 |
58375-58377 |
CD |
denotes |
98 |
T14638 |
58377-58378 |
. |
denotes |
. |
T14639 |
58378-58440 |
sentence |
denotes |
Great care was taken to counterbalance groups between setups. |
T14640 |
58379-58384 |
JJ |
denotes |
Great |
T14641 |
58385-58389 |
NN |
denotes |
care |
T14642 |
58394-58399 |
VBN |
denotes |
taken |
T14643 |
58390-58393 |
VBD |
denotes |
was |
T14644 |
58400-58402 |
TO |
denotes |
to |
T14645 |
58403-58417 |
VB |
denotes |
counterbalance |
T14646 |
58418-58424 |
NNS |
denotes |
groups |
T14647 |
58425-58432 |
IN |
denotes |
between |
T14648 |
58433-58439 |
NNS |
denotes |
setups |
T14649 |
58439-58440 |
. |
denotes |
. |
T14650 |
58440-58690 |
sentence |
denotes |
In brief, animals were presented with odor from one out of eight possible odor channels and rewarded with a 2- to 4-μl drop of water in a combined odor/reward port (Figure 1B), ensuring tight association of the water-reward with a presented odorant. |
T14652 |
58464-58473 |
VBN |
denotes |
presented |
T14653 |
58444-58449 |
NN |
denotes |
brief |
T14654 |
58449-58451 |
, |
denotes |
, |
T14655 |
58451-58458 |
NNS |
denotes |
animals |
T14656 |
58459-58463 |
VBD |
denotes |
were |
T14657 |
58474-58478 |
IN |
denotes |
with |
T14658 |
58479-58483 |
NN |
denotes |
odor |
T14659 |
58484-58488 |
IN |
denotes |
from |
T14660 |
58489-58492 |
CD |
denotes |
one |
T14661 |
58500-58505 |
CD |
denotes |
eight |
T14662 |
58493-58496 |
IN |
denotes |
out |
T14663 |
58497-58499 |
IN |
denotes |
of |
T14664 |
58520-58528 |
NNS |
denotes |
channels |
T14665 |
58506-58514 |
JJ |
denotes |
possible |
T14666 |
58515-58519 |
NN |
denotes |
odor |
T14667 |
58529-58532 |
CC |
denotes |
and |
T14668 |
58533-58541 |
VBN |
denotes |
rewarded |
T14669 |
58542-58546 |
IN |
denotes |
with |
T14670 |
58547-58548 |
DT |
denotes |
a |
T14671 |
58560-58564 |
NN |
denotes |
drop |
T14672 |
58549-58550 |
CD |
denotes |
2 |
T14673 |
58555-58556 |
CD |
denotes |
4 |
T14674 |
58550-58551 |
HYPH |
denotes |
- |
T14675 |
58552-58554 |
IN |
denotes |
to |
T14676 |
58557-58559 |
NN |
denotes |
μl |
T14677 |
58556-58557 |
HYPH |
denotes |
- |
T14678 |
58565-58567 |
IN |
denotes |
of |
T14679 |
58568-58573 |
NN |
denotes |
water |
T14680 |
58574-58576 |
IN |
denotes |
in |
T14681 |
58577-58578 |
DT |
denotes |
a |
T14682 |
58600-58604 |
NN |
denotes |
port |
T14683 |
58579-58587 |
VBN |
denotes |
combined |
T14684 |
58588-58592 |
NN |
denotes |
odor |
T14685 |
58593-58599 |
NN |
denotes |
reward |
T14686 |
58592-58593 |
HYPH |
denotes |
/ |
T14687 |
58605-58606 |
-LRB- |
denotes |
( |
T14688 |
58613-58615 |
NN |
denotes |
1B |
T14689 |
58606-58612 |
NN |
denotes |
Figure |
T14690 |
58615-58616 |
-RRB- |
denotes |
) |
T14691 |
58616-58618 |
, |
denotes |
, |
T14692 |
58618-58626 |
VBG |
denotes |
ensuring |
T14693 |
58627-58632 |
JJ |
denotes |
tight |
T14694 |
58633-58644 |
NN |
denotes |
association |
T14695 |
58645-58647 |
IN |
denotes |
of |
T14696 |
58648-58651 |
DT |
denotes |
the |
T14697 |
58658-58664 |
NN |
denotes |
reward |
T14698 |
58652-58657 |
NN |
denotes |
water |
T14699 |
58657-58658 |
HYPH |
denotes |
- |
T14700 |
58665-58669 |
IN |
denotes |
with |
T14701 |
58670-58671 |
DT |
denotes |
a |
T14702 |
58682-58689 |
NN |
denotes |
odorant |
T14703 |
58672-58681 |
VBN |
denotes |
presented |
T14704 |
58689-58690 |
. |
denotes |
. |
T14705 |
58690-58775 |
sentence |
denotes |
Head insertion into the port was monitored by an IR beam and photodiode (Figure 1B). |
T14706 |
58691-58695 |
NN |
denotes |
Head |
T14707 |
58696-58705 |
NN |
denotes |
insertion |
T14708 |
58724-58733 |
VBN |
denotes |
monitored |
T14709 |
58706-58710 |
IN |
denotes |
into |
T14710 |
58711-58714 |
DT |
denotes |
the |
T14711 |
58715-58719 |
NN |
denotes |
port |
T14712 |
58720-58723 |
VBD |
denotes |
was |
T14713 |
58734-58736 |
IN |
denotes |
by |
T14714 |
58737-58739 |
DT |
denotes |
an |
T14715 |
58743-58747 |
NN |
denotes |
beam |
T14716 |
58740-58742 |
NN |
denotes |
IR |
T14717 |
58748-58751 |
CC |
denotes |
and |
T14718 |
58752-58762 |
NN |
denotes |
photodiode |
T14719 |
58763-58764 |
-LRB- |
denotes |
( |
T14720 |
58771-58773 |
NN |
denotes |
1B |
T14721 |
58764-58770 |
NN |
denotes |
Figure |
T14722 |
58773-58774 |
-RRB- |
denotes |
) |
T14723 |
58774-58775 |
. |
denotes |
. |
T14724 |
58775-58897 |
sentence |
denotes |
Odors used were n-amyl acetate, ethyl butyrate, pelargonic acid, valeric acid, and binary mixtures of cineol and eugenol. |
T14725 |
58776-58781 |
NNS |
denotes |
Odors |
T14726 |
58787-58791 |
VBD |
denotes |
were |
T14727 |
58782-58786 |
VBN |
denotes |
used |
T14728 |
58792-58793 |
NN |
denotes |
n |
T14729 |
58794-58798 |
NN |
denotes |
amyl |
T14730 |
58793-58794 |
HYPH |
denotes |
- |
T14731 |
58799-58806 |
NN |
denotes |
acetate |
T14732 |
58806-58808 |
, |
denotes |
, |
T14733 |
58808-58813 |
NN |
denotes |
ethyl |
T14734 |
58814-58822 |
NN |
denotes |
butyrate |
T14735 |
58822-58824 |
, |
denotes |
, |
T14736 |
58824-58834 |
JJ |
denotes |
pelargonic |
T14737 |
58835-58839 |
NN |
denotes |
acid |
T14738 |
58839-58841 |
, |
denotes |
, |
T14739 |
58841-58848 |
JJ |
denotes |
valeric |
T14740 |
58849-58853 |
NN |
denotes |
acid |
T14741 |
58853-58855 |
, |
denotes |
, |
T14742 |
58855-58858 |
CC |
denotes |
and |
T14743 |
58859-58865 |
JJ |
denotes |
binary |
T14744 |
58866-58874 |
NNS |
denotes |
mixtures |
T14745 |
58875-58877 |
IN |
denotes |
of |
T14746 |
58878-58884 |
NN |
denotes |
cineol |
T14747 |
58885-58888 |
CC |
denotes |
and |
T14748 |
58889-58896 |
NN |
denotes |
eugenol |
T14749 |
58896-58897 |
. |
denotes |
. |
T14750 |
58897-59076 |
sentence |
denotes |
If not otherwise noted, odors were diluted to 1% in mineral oil (Fluka Chemie, Steinheim, Germany) and further diluted by airflow to a final concentration of approximately 0.15%. |
T14751 |
58898-58900 |
IN |
denotes |
If |
T14752 |
58915-58920 |
VBN |
denotes |
noted |
T14753 |
58901-58904 |
RB |
denotes |
not |
T14754 |
58905-58914 |
RB |
denotes |
otherwise |
T14755 |
58933-58940 |
VBN |
denotes |
diluted |
T14756 |
58920-58922 |
, |
denotes |
, |
T14757 |
58922-58927 |
NNS |
denotes |
odors |
T14758 |
58928-58932 |
VBD |
denotes |
were |
T14759 |
58941-58943 |
IN |
denotes |
to |
T14760 |
58944-58945 |
CD |
denotes |
1 |
T14761 |
58945-58946 |
NN |
denotes |
% |
T14762 |
58947-58949 |
IN |
denotes |
in |
T14763 |
58950-58957 |
NN |
denotes |
mineral |
T14764 |
58958-58961 |
NN |
denotes |
oil |
T14765 |
58962-58963 |
-LRB- |
denotes |
( |
T14766 |
58969-58975 |
NNP |
denotes |
Chemie |
T14767 |
58963-58968 |
NNP |
denotes |
Fluka |
T14768 |
58975-58977 |
, |
denotes |
, |
T14769 |
58977-58986 |
NNP |
denotes |
Steinheim |
T14770 |
58986-58988 |
, |
denotes |
, |
T14771 |
58988-58995 |
NNP |
denotes |
Germany |
T14772 |
58995-58996 |
-RRB- |
denotes |
) |
T14773 |
58997-59000 |
CC |
denotes |
and |
T14774 |
59001-59008 |
RB |
denotes |
further |
T14775 |
59009-59016 |
VBN |
denotes |
diluted |
T14776 |
59017-59019 |
IN |
denotes |
by |
T14777 |
59020-59027 |
NN |
denotes |
airflow |
T14778 |
59028-59030 |
IN |
denotes |
to |
T14779 |
59031-59032 |
DT |
denotes |
a |
T14780 |
59039-59052 |
NN |
denotes |
concentration |
T14781 |
59033-59038 |
JJ |
denotes |
final |
T14782 |
59053-59055 |
IN |
denotes |
of |
T14783 |
59056-59069 |
RB |
denotes |
approximately |
T14784 |
59070-59074 |
CD |
denotes |
0.15 |
T14785 |
59074-59075 |
NN |
denotes |
% |
T14786 |
59075-59076 |
. |
denotes |
. |
T14787 |
59076-59140 |
sentence |
denotes |
All dilutions in the text refer to the dilution in mineral oil. |
T14788 |
59077-59080 |
DT |
denotes |
All |
T14789 |
59081-59090 |
NNS |
denotes |
dilutions |
T14790 |
59103-59108 |
VBP |
denotes |
refer |
T14791 |
59091-59093 |
IN |
denotes |
in |
T14792 |
59094-59097 |
DT |
denotes |
the |
T14793 |
59098-59102 |
NN |
denotes |
text |
T14794 |
59109-59111 |
IN |
denotes |
to |
T14795 |
59112-59115 |
DT |
denotes |
the |
T14796 |
59116-59124 |
NN |
denotes |
dilution |
T14797 |
59125-59127 |
IN |
denotes |
in |
T14798 |
59128-59135 |
NN |
denotes |
mineral |
T14799 |
59136-59139 |
NN |
denotes |
oil |
T14800 |
59139-59140 |
. |
denotes |
. |
T14801 |
59140-59187 |
sentence |
denotes |
All chemicals were obtained from Fluka Chemie. |
T14802 |
59141-59144 |
DT |
denotes |
All |
T14803 |
59145-59154 |
NNS |
denotes |
chemicals |
T14804 |
59160-59168 |
VBN |
denotes |
obtained |
T14805 |
59155-59159 |
VBD |
denotes |
were |
T14806 |
59169-59173 |
IN |
denotes |
from |
T14807 |
59174-59179 |
NNP |
denotes |
Fluka |
T14808 |
59180-59186 |
NNP |
denotes |
Chemie |
T14809 |
59186-59187 |
. |
denotes |
. |
T14842 |
59189-59193 |
NN |
denotes |
Task |
T14843 |
59194-59205 |
NN |
denotes |
habituation |
T14844 |
59206-59214 |
NN |
denotes |
training |
T14845 |
59214-59354 |
sentence |
denotes |
Beginning 1–3 d after the start of the water restriction schedule, animals were trained using standard operant-conditioning procedures [3]. |
T14846 |
59215-59224 |
VBG |
denotes |
Beginning |
T14847 |
59295-59302 |
VBN |
denotes |
trained |
T14848 |
59225-59226 |
CD |
denotes |
1 |
T14849 |
59227-59228 |
CD |
denotes |
3 |
T14850 |
59226-59227 |
SYM |
denotes |
– |
T14851 |
59229-59230 |
NN |
denotes |
d |
T14852 |
59231-59236 |
IN |
denotes |
after |
T14853 |
59237-59240 |
DT |
denotes |
the |
T14854 |
59241-59246 |
NN |
denotes |
start |
T14855 |
59247-59249 |
IN |
denotes |
of |
T14856 |
59250-59253 |
DT |
denotes |
the |
T14857 |
59272-59280 |
NN |
denotes |
schedule |
T14858 |
59254-59259 |
NN |
denotes |
water |
T14859 |
59260-59271 |
NN |
denotes |
restriction |
T14860 |
59280-59282 |
, |
denotes |
, |
T14861 |
59282-59289 |
NNS |
denotes |
animals |
T14862 |
59290-59294 |
VBD |
denotes |
were |
T14863 |
59303-59308 |
VBG |
denotes |
using |
T14864 |
59309-59317 |
JJ |
denotes |
standard |
T14865 |
59339-59349 |
NNS |
denotes |
procedures |
T14866 |
59318-59325 |
NN |
denotes |
operant |
T14867 |
59325-59326 |
HYPH |
denotes |
- |
T14868 |
59326-59338 |
VBG |
denotes |
conditioning |
T14869 |
59350-59351 |
-LRB- |
denotes |
[ |
T14870 |
59351-59352 |
CD |
denotes |
3 |
T14871 |
59352-59353 |
-RRB- |
denotes |
] |
T14872 |
59353-59354 |
. |
denotes |
. |
T14873 |
59354-59434 |
sentence |
denotes |
In a first pretraining step, each lick at the water delivery tube was rewarded. |
T14874 |
59355-59357 |
IN |
denotes |
In |
T14875 |
59425-59433 |
VBN |
denotes |
rewarded |
T14876 |
59358-59359 |
DT |
denotes |
a |
T14877 |
59378-59382 |
NN |
denotes |
step |
T14878 |
59360-59365 |
JJ |
denotes |
first |
T14879 |
59366-59377 |
NN |
denotes |
pretraining |
T14880 |
59382-59384 |
, |
denotes |
, |
T14881 |
59384-59388 |
DT |
denotes |
each |
T14882 |
59389-59393 |
NN |
denotes |
lick |
T14883 |
59394-59396 |
IN |
denotes |
at |
T14884 |
59397-59400 |
DT |
denotes |
the |
T14885 |
59416-59420 |
NN |
denotes |
tube |
T14886 |
59401-59406 |
NN |
denotes |
water |
T14887 |
59407-59415 |
NN |
denotes |
delivery |
T14888 |
59421-59424 |
VBD |
denotes |
was |
T14889 |
59433-59434 |
. |
denotes |
. |
T14890 |
59434-59571 |
sentence |
denotes |
After 20 licks, a second stage was entered in which head insertion initiated a 2-s “odor” presentation during which a lick was rewarded. |
T14891 |
59435-59440 |
IN |
denotes |
After |
T14892 |
59470-59477 |
VBN |
denotes |
entered |
T14893 |
59441-59443 |
CD |
denotes |
20 |
T14894 |
59444-59449 |
NNS |
denotes |
licks |
T14895 |
59449-59451 |
, |
denotes |
, |
T14896 |
59451-59452 |
DT |
denotes |
a |
T14897 |
59460-59465 |
NN |
denotes |
stage |
T14898 |
59453-59459 |
JJ |
denotes |
second |
T14899 |
59466-59469 |
VBD |
denotes |
was |
T14900 |
59478-59480 |
IN |
denotes |
in |
T14901 |
59502-59511 |
VBD |
denotes |
initiated |
T14902 |
59481-59486 |
WDT |
denotes |
which |
T14903 |
59487-59491 |
NN |
denotes |
head |
T14904 |
59492-59501 |
NN |
denotes |
insertion |
T14905 |
59512-59513 |
DT |
denotes |
a |
T14906 |
59525-59537 |
NN |
denotes |
presentation |
T14907 |
59514-59515 |
CD |
denotes |
2 |
T14908 |
59516-59517 |
NN |
denotes |
s |
T14909 |
59515-59516 |
HYPH |
denotes |
- |
T14910 |
59518-59519 |
`` |
denotes |
“ |
T14911 |
59519-59523 |
NN |
denotes |
odor |
T14912 |
59523-59524 |
'' |
denotes |
” |
T14913 |
59538-59544 |
IN |
denotes |
during |
T14914 |
59562-59570 |
VBN |
denotes |
rewarded |
T14915 |
59545-59550 |
WDT |
denotes |
which |
T14916 |
59551-59552 |
DT |
denotes |
a |
T14917 |
59553-59557 |
NN |
denotes |
lick |
T14918 |
59558-59561 |
VBD |
denotes |
was |
T14919 |
59570-59571 |
. |
denotes |
. |
T14920 |
59571-59645 |
sentence |
denotes |
The “odorant” used in the pretraining was the carrier medium mineral oil. |
T14921 |
59572-59575 |
DT |
denotes |
The |
T14922 |
59577-59584 |
NN |
denotes |
odorant |
T14923 |
59576-59577 |
`` |
denotes |
“ |
T14924 |
59610-59613 |
VBD |
denotes |
was |
T14925 |
59584-59585 |
'' |
denotes |
” |
T14926 |
59586-59590 |
VBN |
denotes |
used |
T14927 |
59591-59593 |
IN |
denotes |
in |
T14928 |
59594-59597 |
DT |
denotes |
the |
T14929 |
59598-59609 |
NN |
denotes |
pretraining |
T14930 |
59614-59617 |
DT |
denotes |
the |
T14931 |
59626-59632 |
NN |
denotes |
medium |
T14932 |
59618-59625 |
NN |
denotes |
carrier |
T14933 |
59633-59640 |
NN |
denotes |
mineral |
T14934 |
59641-59644 |
NN |
denotes |
oil |
T14935 |
59644-59645 |
. |
denotes |
. |
T14936 |
59645-59718 |
sentence |
denotes |
All animals learned this task within one day (2–3 sessions 30 min each). |
T14937 |
59646-59649 |
DT |
denotes |
All |
T14938 |
59650-59657 |
NNS |
denotes |
animals |
T14939 |
59658-59665 |
VBD |
denotes |
learned |
T14940 |
59666-59670 |
DT |
denotes |
this |
T14941 |
59671-59675 |
NN |
denotes |
task |
T14942 |
59676-59682 |
IN |
denotes |
within |
T14943 |
59683-59686 |
CD |
denotes |
one |
T14944 |
59687-59690 |
NN |
denotes |
day |
T14945 |
59691-59692 |
-LRB- |
denotes |
( |
T14946 |
59696-59704 |
NNS |
denotes |
sessions |
T14947 |
59692-59693 |
CD |
denotes |
2 |
T14948 |
59694-59695 |
CD |
denotes |
3 |
T14949 |
59693-59694 |
SYM |
denotes |
– |
T14950 |
59705-59707 |
CD |
denotes |
30 |
T14951 |
59708-59711 |
NN |
denotes |
min |
T14952 |
59712-59716 |
DT |
denotes |
each |
T14953 |
59716-59717 |
-RRB- |
denotes |
) |
T14954 |
59717-59718 |
. |
denotes |
. |
T14984 |
59720-59729 |
NN |
denotes |
Structure |
T14985 |
59730-59732 |
IN |
denotes |
of |
T14986 |
59733-59735 |
DT |
denotes |
an |
T14987 |
59747-59752 |
NN |
denotes |
trial |
T14988 |
59736-59746 |
JJ |
denotes |
individual |
T14989 |
59752-59863 |
sentence |
denotes |
The mouse initiates each trial by breaking a light barrier at the opening of the sampling port (see also [3]). |
T14990 |
59753-59756 |
DT |
denotes |
The |
T14991 |
59757-59762 |
NN |
denotes |
mouse |
T14992 |
59763-59772 |
VBZ |
denotes |
initiates |
T14993 |
59773-59777 |
DT |
denotes |
each |
T14994 |
59778-59783 |
NN |
denotes |
trial |
T14995 |
59784-59786 |
IN |
denotes |
by |
T14996 |
59787-59795 |
VBG |
denotes |
breaking |
T14997 |
59796-59797 |
DT |
denotes |
a |
T14998 |
59804-59811 |
NN |
denotes |
barrier |
T14999 |
59798-59803 |
NN |
denotes |
light |
T15000 |
59812-59814 |
IN |
denotes |
at |
T15001 |
59815-59818 |
DT |
denotes |
the |
T15002 |
59819-59826 |
NN |
denotes |
opening |
T15003 |
59827-59829 |
IN |
denotes |
of |
T15004 |
59830-59833 |
DT |
denotes |
the |
T15005 |
59843-59847 |
NN |
denotes |
port |
T15006 |
59834-59842 |
NN |
denotes |
sampling |
T15007 |
59848-59849 |
-LRB- |
denotes |
( |
T15008 |
59849-59852 |
VB |
denotes |
see |
T15009 |
59853-59857 |
RB |
denotes |
also |
T15010 |
59858-59859 |
-LRB- |
denotes |
[ |
T15011 |
59859-59860 |
CD |
denotes |
3 |
T15012 |
59860-59861 |
-RRB- |
denotes |
] |
T15013 |
59861-59862 |
-RRB- |
denotes |
) |
T15014 |
59862-59863 |
. |
denotes |
. |
T15015 |
59863-59991 |
sentence |
denotes |
This opens one of eight odor valves, and a diversion valve that diverts all air flow away from the animal for typically 500 ms. |
T15016 |
59864-59868 |
DT |
denotes |
This |
T15017 |
59869-59874 |
VBZ |
denotes |
opens |
T15018 |
59875-59878 |
CD |
denotes |
one |
T15019 |
59879-59881 |
IN |
denotes |
of |
T15020 |
59882-59887 |
CD |
denotes |
eight |
T15021 |
59893-59899 |
NNS |
denotes |
valves |
T15022 |
59888-59892 |
NN |
denotes |
odor |
T15023 |
59899-59901 |
, |
denotes |
, |
T15024 |
59901-59904 |
CC |
denotes |
and |
T15025 |
59905-59906 |
DT |
denotes |
a |
T15026 |
59917-59922 |
NN |
denotes |
valve |
T15027 |
59907-59916 |
NN |
denotes |
diversion |
T15028 |
59923-59927 |
WDT |
denotes |
that |
T15029 |
59928-59935 |
VBZ |
denotes |
diverts |
T15030 |
59936-59939 |
DT |
denotes |
all |
T15031 |
59944-59948 |
NN |
denotes |
flow |
T15032 |
59940-59943 |
NN |
denotes |
air |
T15033 |
59949-59953 |
RB |
denotes |
away |
T15034 |
59954-59958 |
IN |
denotes |
from |
T15035 |
59959-59962 |
DT |
denotes |
the |
T15036 |
59963-59969 |
NN |
denotes |
animal |
T15037 |
59970-59973 |
IN |
denotes |
for |
T15038 |
59974-59983 |
RB |
denotes |
typically |
T15039 |
59988-59990 |
NNS |
denotes |
ms |
T15040 |
59984-59987 |
CD |
denotes |
500 |
T15041 |
59990-59991 |
. |
denotes |
. |
T15042 |
59991-60084 |
sentence |
denotes |
After the release of the diversion valve, the odor is accessible to the animal for 2,000 ms. |
T15043 |
59992-59997 |
IN |
denotes |
After |
T15044 |
60043-60045 |
VBZ |
denotes |
is |
T15045 |
59998-60001 |
DT |
denotes |
the |
T15046 |
60002-60009 |
NN |
denotes |
release |
T15047 |
60010-60012 |
IN |
denotes |
of |
T15048 |
60013-60016 |
DT |
denotes |
the |
T15049 |
60027-60032 |
NN |
denotes |
valve |
T15050 |
60017-60026 |
NN |
denotes |
diversion |
T15051 |
60032-60034 |
, |
denotes |
, |
T15052 |
60034-60037 |
DT |
denotes |
the |
T15053 |
60038-60042 |
NN |
denotes |
odor |
T15054 |
60046-60056 |
JJ |
denotes |
accessible |
T15055 |
60057-60059 |
IN |
denotes |
to |
T15056 |
60060-60063 |
DT |
denotes |
the |
T15057 |
60064-60070 |
NN |
denotes |
animal |
T15058 |
60071-60074 |
IN |
denotes |
for |
T15059 |
60075-60080 |
CD |
denotes |
2,000 |
T15060 |
60081-60083 |
NNS |
denotes |
ms |
T15061 |
60083-60084 |
. |
denotes |
. |
T15062 |
60084-60272 |
sentence |
denotes |
If it continuously licks at the lick port during this time (once in at least three out of four 500-ms bins), it can receive a 2- to 4-μl water reward after the end of the 2,000-ms period. |
T15063 |
60085-60087 |
IN |
denotes |
If |
T15064 |
60104-60109 |
VBZ |
denotes |
licks |
T15065 |
60088-60090 |
PRP |
denotes |
it |
T15066 |
60091-60103 |
RB |
denotes |
continuously |
T15067 |
60201-60208 |
VB |
denotes |
receive |
T15068 |
60110-60112 |
IN |
denotes |
at |
T15069 |
60113-60116 |
DT |
denotes |
the |
T15070 |
60122-60126 |
NN |
denotes |
port |
T15071 |
60117-60121 |
NN |
denotes |
lick |
T15072 |
60127-60133 |
IN |
denotes |
during |
T15073 |
60134-60138 |
DT |
denotes |
this |
T15074 |
60139-60143 |
NN |
denotes |
time |
T15075 |
60144-60145 |
-LRB- |
denotes |
( |
T15076 |
60150-60152 |
IN |
denotes |
in |
T15077 |
60145-60149 |
RB |
denotes |
once |
T15078 |
60153-60155 |
RB |
denotes |
at |
T15079 |
60156-60161 |
RBS |
denotes |
least |
T15080 |
60175-60179 |
CD |
denotes |
four |
T15081 |
60162-60167 |
CD |
denotes |
three |
T15082 |
60168-60171 |
IN |
denotes |
out |
T15083 |
60172-60174 |
IN |
denotes |
of |
T15084 |
60187-60191 |
NNS |
denotes |
bins |
T15085 |
60180-60183 |
CD |
denotes |
500 |
T15086 |
60184-60186 |
NN |
denotes |
ms |
T15087 |
60183-60184 |
HYPH |
denotes |
- |
T15088 |
60191-60192 |
-RRB- |
denotes |
) |
T15089 |
60192-60194 |
, |
denotes |
, |
T15090 |
60194-60196 |
PRP |
denotes |
it |
T15091 |
60197-60200 |
MD |
denotes |
can |
T15092 |
60209-60210 |
DT |
denotes |
a |
T15093 |
60228-60234 |
NN |
denotes |
reward |
T15094 |
60211-60212 |
CD |
denotes |
2 |
T15095 |
60217-60218 |
CD |
denotes |
4 |
T15096 |
60212-60213 |
HYPH |
denotes |
- |
T15097 |
60214-60216 |
IN |
denotes |
to |
T15098 |
60219-60221 |
NN |
denotes |
μl |
T15099 |
60218-60219 |
HYPH |
denotes |
- |
T15100 |
60222-60227 |
NN |
denotes |
water |
T15101 |
60235-60240 |
IN |
denotes |
after |
T15102 |
60241-60244 |
DT |
denotes |
the |
T15103 |
60245-60248 |
NN |
denotes |
end |
T15104 |
60249-60251 |
IN |
denotes |
of |
T15105 |
60252-60255 |
DT |
denotes |
the |
T15106 |
60265-60271 |
NN |
denotes |
period |
T15107 |
60256-60261 |
CD |
denotes |
2,000 |
T15108 |
60262-60264 |
NN |
denotes |
ms |
T15109 |
60261-60262 |
HYPH |
denotes |
- |
T15110 |
60271-60272 |
. |
denotes |
. |
T15111 |
60272-60463 |
sentence |
denotes |
If the animal does not continuously lick, or if the presented odor was a designated nonrewarded odor, neither a reward is given nor any sort of punishment, to minimize stress for the animal. |
T15112 |
60273-60275 |
IN |
denotes |
If |
T15113 |
60309-60313 |
VB |
denotes |
lick |
T15114 |
60276-60279 |
DT |
denotes |
the |
T15115 |
60280-60286 |
NN |
denotes |
animal |
T15116 |
60287-60291 |
VBZ |
denotes |
does |
T15117 |
60292-60295 |
RB |
denotes |
not |
T15118 |
60296-60308 |
RB |
denotes |
continuously |
T15119 |
60395-60400 |
VBN |
denotes |
given |
T15120 |
60313-60315 |
, |
denotes |
, |
T15121 |
60315-60317 |
CC |
denotes |
or |
T15122 |
60318-60320 |
IN |
denotes |
if |
T15123 |
60340-60343 |
VBD |
denotes |
was |
T15124 |
60321-60324 |
DT |
denotes |
the |
T15125 |
60335-60339 |
NN |
denotes |
odor |
T15126 |
60325-60334 |
VBN |
denotes |
presented |
T15127 |
60344-60345 |
DT |
denotes |
a |
T15128 |
60369-60373 |
NN |
denotes |
odor |
T15129 |
60346-60356 |
VBN |
denotes |
designated |
T15130 |
60357-60368 |
JJ |
denotes |
nonrewarded |
T15131 |
60373-60375 |
, |
denotes |
, |
T15132 |
60375-60382 |
CC |
denotes |
neither |
T15133 |
60385-60391 |
NN |
denotes |
reward |
T15134 |
60383-60384 |
DT |
denotes |
a |
T15135 |
60392-60394 |
VBZ |
denotes |
is |
T15136 |
60401-60404 |
CC |
denotes |
nor |
T15137 |
60409-60413 |
NN |
denotes |
sort |
T15138 |
60405-60408 |
DT |
denotes |
any |
T15139 |
60414-60416 |
IN |
denotes |
of |
T15140 |
60417-60427 |
NN |
denotes |
punishment |
T15141 |
60427-60429 |
, |
denotes |
, |
T15142 |
60429-60431 |
TO |
denotes |
to |
T15143 |
60432-60440 |
VB |
denotes |
minimize |
T15144 |
60441-60447 |
NN |
denotes |
stress |
T15145 |
60448-60451 |
IN |
denotes |
for |
T15146 |
60452-60455 |
DT |
denotes |
the |
T15147 |
60456-60462 |
NN |
denotes |
animal |
T15148 |
60462-60463 |
. |
denotes |
. |
T15149 |
60463-60618 |
sentence |
denotes |
Trials are counted as correct if the animal licks continuously upon presentation of a rewarded odor or does not lick continuously with a nonrewarded odor. |
T15150 |
60464-60470 |
NNS |
denotes |
Trials |
T15151 |
60475-60482 |
VBN |
denotes |
counted |
T15152 |
60471-60474 |
VBP |
denotes |
are |
T15153 |
60483-60485 |
IN |
denotes |
as |
T15154 |
60486-60493 |
JJ |
denotes |
correct |
T15155 |
60494-60496 |
IN |
denotes |
if |
T15156 |
60508-60513 |
VBZ |
denotes |
licks |
T15157 |
60497-60500 |
DT |
denotes |
the |
T15158 |
60501-60507 |
NN |
denotes |
animal |
T15159 |
60514-60526 |
RB |
denotes |
continuously |
T15160 |
60527-60531 |
IN |
denotes |
upon |
T15161 |
60532-60544 |
NN |
denotes |
presentation |
T15162 |
60545-60547 |
IN |
denotes |
of |
T15163 |
60548-60549 |
DT |
denotes |
a |
T15164 |
60559-60563 |
NN |
denotes |
odor |
T15165 |
60550-60558 |
VBN |
denotes |
rewarded |
T15166 |
60564-60566 |
CC |
denotes |
or |
T15167 |
60567-60571 |
VBZ |
denotes |
does |
T15168 |
60576-60580 |
VB |
denotes |
lick |
T15169 |
60572-60575 |
RB |
denotes |
not |
T15170 |
60581-60593 |
RB |
denotes |
continuously |
T15171 |
60594-60598 |
IN |
denotes |
with |
T15172 |
60599-60600 |
DT |
denotes |
a |
T15173 |
60613-60617 |
NN |
denotes |
odor |
T15174 |
60601-60612 |
JJ |
denotes |
nonrewarded |
T15175 |
60617-60618 |
. |
denotes |
. |
T15176 |
60618-60711 |
sentence |
denotes |
A second trial cannot be initiated unless an intertrial interval of at least 5 s has passed. |
T15177 |
60619-60620 |
DT |
denotes |
A |
T15178 |
60628-60633 |
NN |
denotes |
trial |
T15179 |
60621-60627 |
JJ |
denotes |
second |
T15180 |
60644-60653 |
VBN |
denotes |
initiated |
T15181 |
60634-60637 |
MD |
denotes |
can |
T15182 |
60637-60640 |
RB |
denotes |
not |
T15183 |
60641-60643 |
VB |
denotes |
be |
T15184 |
60654-60660 |
IN |
denotes |
unless |
T15185 |
60704-60710 |
VBN |
denotes |
passed |
T15186 |
60661-60663 |
DT |
denotes |
an |
T15187 |
60675-60683 |
NN |
denotes |
interval |
T15188 |
60664-60674 |
JJ |
denotes |
intertrial |
T15189 |
60684-60686 |
IN |
denotes |
of |
T15190 |
60687-60689 |
RB |
denotes |
at |
T15191 |
60690-60695 |
RBS |
denotes |
least |
T15192 |
60696-60697 |
CD |
denotes |
5 |
T15193 |
60698-60699 |
NN |
denotes |
s |
T15194 |
60700-60703 |
VBZ |
denotes |
has |
T15195 |
60710-60711 |
. |
denotes |
. |
T15196 |
60711-60816 |
sentence |
denotes |
This interval is sufficiently long so that animals typically retract quickly after the end of the trial. |
T15197 |
60712-60716 |
DT |
denotes |
This |
T15198 |
60717-60725 |
NN |
denotes |
interval |
T15199 |
60726-60728 |
VBZ |
denotes |
is |
T15200 |
60729-60741 |
RB |
denotes |
sufficiently |
T15201 |
60742-60746 |
JJ |
denotes |
long |
T15202 |
60747-60749 |
RB |
denotes |
so |
T15203 |
60773-60780 |
VBP |
denotes |
retract |
T15204 |
60750-60754 |
IN |
denotes |
that |
T15205 |
60755-60762 |
NNS |
denotes |
animals |
T15206 |
60763-60772 |
RB |
denotes |
typically |
T15207 |
60781-60788 |
RB |
denotes |
quickly |
T15208 |
60789-60794 |
IN |
denotes |
after |
T15209 |
60795-60798 |
DT |
denotes |
the |
T15210 |
60799-60802 |
NN |
denotes |
end |
T15211 |
60803-60805 |
IN |
denotes |
of |
T15212 |
60806-60809 |
DT |
denotes |
the |
T15213 |
60810-60815 |
NN |
denotes |
trial |
T15214 |
60815-60816 |
. |
denotes |
. |
T15215 |
60816-60970 |
sentence |
denotes |
Odors are presented in a pseudo-randomized scheme (no more than two successive presentations of the same odor, equal numbers within each 20-trial block). |
T15216 |
60817-60822 |
NNS |
denotes |
Odors |
T15217 |
60827-60836 |
VBN |
denotes |
presented |
T15218 |
60823-60826 |
VBP |
denotes |
are |
T15219 |
60837-60839 |
IN |
denotes |
in |
T15220 |
60840-60841 |
DT |
denotes |
a |
T15221 |
60860-60866 |
NN |
denotes |
scheme |
T15222 |
60842-60859 |
JJ |
denotes |
pseudo-randomized |
T15223 |
60867-60868 |
-LRB- |
denotes |
( |
T15224 |
60934-60941 |
NNS |
denotes |
numbers |
T15225 |
60868-60870 |
DT |
denotes |
no |
T15226 |
60881-60884 |
CD |
denotes |
two |
T15227 |
60871-60875 |
JJR |
denotes |
more |
T15228 |
60876-60880 |
IN |
denotes |
than |
T15229 |
60896-60909 |
NNS |
denotes |
presentations |
T15230 |
60885-60895 |
JJ |
denotes |
successive |
T15231 |
60910-60912 |
IN |
denotes |
of |
T15232 |
60913-60916 |
DT |
denotes |
the |
T15233 |
60922-60926 |
NN |
denotes |
odor |
T15234 |
60917-60921 |
JJ |
denotes |
same |
T15235 |
60926-60928 |
, |
denotes |
, |
T15236 |
60928-60933 |
JJ |
denotes |
equal |
T15237 |
60942-60948 |
IN |
denotes |
within |
T15238 |
60949-60953 |
DT |
denotes |
each |
T15239 |
60963-60968 |
NN |
denotes |
block |
T15240 |
60954-60956 |
CD |
denotes |
20 |
T15241 |
60957-60962 |
NN |
denotes |
trial |
T15242 |
60956-60957 |
HYPH |
denotes |
- |
T15243 |
60968-60969 |
-RRB- |
denotes |
) |
T15244 |
60969-60970 |
. |
denotes |
. |
T15245 |
60970-61071 |
sentence |
denotes |
No intrinsic preference toward any of the odors was observed but controlled for by counterbalancing. |
T15246 |
60971-60973 |
DT |
denotes |
No |
T15247 |
60984-60994 |
NN |
denotes |
preference |
T15248 |
60974-60983 |
JJ |
denotes |
intrinsic |
T15249 |
61023-61031 |
VBN |
denotes |
observed |
T15250 |
60995-61001 |
IN |
denotes |
toward |
T15251 |
61002-61005 |
DT |
denotes |
any |
T15252 |
61006-61008 |
IN |
denotes |
of |
T15253 |
61009-61012 |
DT |
denotes |
the |
T15254 |
61013-61018 |
NNS |
denotes |
odors |
T15255 |
61019-61022 |
VBD |
denotes |
was |
T15256 |
61032-61035 |
CC |
denotes |
but |
T15257 |
61036-61046 |
VBN |
denotes |
controlled |
T15258 |
61047-61050 |
IN |
denotes |
for |
T15259 |
61051-61053 |
IN |
denotes |
by |
T15260 |
61054-61070 |
NN |
denotes |
counterbalancing |
T15261 |
61070-61071 |
. |
denotes |
. |
T15262 |
61071-61233 |
sentence |
denotes |
A total of 100–300 trials were performed each day, separated into 30- to 40-min stretches to ensure maximal motivation despite the mild water restriction scheme. |
T15263 |
61072-61073 |
DT |
denotes |
A |
T15264 |
61087-61090 |
CD |
denotes |
300 |
T15265 |
61074-61079 |
NN |
denotes |
total |
T15266 |
61080-61082 |
IN |
denotes |
of |
T15267 |
61083-61086 |
CD |
denotes |
100 |
T15268 |
61086-61087 |
SYM |
denotes |
– |
T15269 |
61091-61097 |
NNS |
denotes |
trials |
T15270 |
61123-61132 |
VBN |
denotes |
separated |
T15271 |
61098-61102 |
VBD |
denotes |
were |
T15272 |
61103-61112 |
VBN |
denotes |
performed |
T15273 |
61113-61117 |
DT |
denotes |
each |
T15274 |
61118-61121 |
NN |
denotes |
day |
T15275 |
61121-61123 |
, |
denotes |
, |
T15276 |
61133-61137 |
IN |
denotes |
into |
T15277 |
61138-61140 |
CD |
denotes |
30 |
T15278 |
61145-61147 |
CD |
denotes |
40 |
T15279 |
61140-61141 |
HYPH |
denotes |
- |
T15280 |
61142-61144 |
IN |
denotes |
to |
T15281 |
61148-61151 |
NN |
denotes |
min |
T15282 |
61147-61148 |
HYPH |
denotes |
- |
T15283 |
61152-61161 |
NNS |
denotes |
stretches |
T15284 |
61162-61164 |
TO |
denotes |
to |
T15285 |
61165-61171 |
VB |
denotes |
ensure |
T15286 |
61172-61179 |
JJ |
denotes |
maximal |
T15287 |
61180-61190 |
NN |
denotes |
motivation |
T15288 |
61191-61198 |
IN |
denotes |
despite |
T15289 |
61199-61202 |
DT |
denotes |
the |
T15290 |
61226-61232 |
NN |
denotes |
scheme |
T15291 |
61203-61207 |
JJ |
denotes |
mild |
T15292 |
61208-61213 |
NN |
denotes |
water |
T15293 |
61214-61225 |
NN |
denotes |
restriction |
T15294 |
61232-61233 |
. |
denotes |
. |
T15295 |
61233-61340 |
sentence |
denotes |
Additionally, motivation was controlled by monitoring intertrial intervals and the response frequency [3]. |
T15296 |
61234-61246 |
RB |
denotes |
Additionally |
T15297 |
61263-61273 |
VBN |
denotes |
controlled |
T15298 |
61246-61248 |
, |
denotes |
, |
T15299 |
61248-61258 |
NN |
denotes |
motivation |
T15300 |
61259-61262 |
VBD |
denotes |
was |
T15301 |
61274-61276 |
IN |
denotes |
by |
T15302 |
61277-61287 |
VBG |
denotes |
monitoring |
T15303 |
61288-61298 |
JJ |
denotes |
intertrial |
T15304 |
61299-61308 |
NNS |
denotes |
intervals |
T15305 |
61309-61312 |
CC |
denotes |
and |
T15306 |
61313-61316 |
DT |
denotes |
the |
T15307 |
61326-61335 |
NN |
denotes |
frequency |
T15308 |
61317-61325 |
NN |
denotes |
response |
T15309 |
61336-61337 |
-LRB- |
denotes |
[ |
T15310 |
61337-61338 |
CD |
denotes |
3 |
T15311 |
61338-61339 |
-RRB- |
denotes |
] |
T15312 |
61339-61340 |
. |
denotes |
. |
T15338 |
61342-61353 |
NN |
denotes |
Measurement |
T15339 |
61354-61356 |
IN |
denotes |
of |
T15340 |
61357-61368 |
NN |
denotes |
performance |
T15341 |
61368-61587 |
sentence |
denotes |
The simplest measure of performance is the fraction of trials in which the animal responds correctly—that is, responds with licking to the presentation of the S+ odor and does not lick with presentation of the S− odor. |
T15342 |
61369-61372 |
DT |
denotes |
The |
T15343 |
61382-61389 |
NN |
denotes |
measure |
T15344 |
61373-61381 |
JJS |
denotes |
simplest |
T15345 |
61405-61407 |
VBZ |
denotes |
is |
T15346 |
61390-61392 |
IN |
denotes |
of |
T15347 |
61393-61404 |
NN |
denotes |
performance |
T15348 |
61408-61411 |
DT |
denotes |
the |
T15349 |
61412-61420 |
NN |
denotes |
fraction |
T15350 |
61421-61423 |
IN |
denotes |
of |
T15351 |
61424-61430 |
NNS |
denotes |
trials |
T15352 |
61431-61433 |
IN |
denotes |
in |
T15353 |
61451-61459 |
VBZ |
denotes |
responds |
T15354 |
61434-61439 |
WDT |
denotes |
which |
T15355 |
61440-61443 |
DT |
denotes |
the |
T15356 |
61444-61450 |
NN |
denotes |
animal |
T15357 |
61460-61469 |
RB |
denotes |
correctly |
T15358 |
61469-61470 |
: |
denotes |
— |
T15359 |
61470-61474 |
RB |
denotes |
that |
T15360 |
61475-61477 |
RB |
denotes |
is |
T15361 |
61479-61487 |
VBZ |
denotes |
responds |
T15362 |
61477-61479 |
, |
denotes |
, |
T15363 |
61488-61492 |
IN |
denotes |
with |
T15364 |
61493-61500 |
NN |
denotes |
licking |
T15365 |
61501-61503 |
IN |
denotes |
to |
T15366 |
61504-61507 |
DT |
denotes |
the |
T15367 |
61508-61520 |
NN |
denotes |
presentation |
T15368 |
61521-61523 |
IN |
denotes |
of |
T15369 |
61524-61527 |
DT |
denotes |
the |
T15370 |
61531-61535 |
NN |
denotes |
odor |
T15371 |
61528-61529 |
NN |
denotes |
S |
T15372 |
61529-61530 |
SYM |
denotes |
+ |
T15373 |
61536-61539 |
CC |
denotes |
and |
T15374 |
61540-61544 |
VBZ |
denotes |
does |
T15375 |
61549-61553 |
VB |
denotes |
lick |
T15376 |
61545-61548 |
RB |
denotes |
not |
T15377 |
61554-61558 |
IN |
denotes |
with |
T15378 |
61559-61571 |
NN |
denotes |
presentation |
T15379 |
61572-61574 |
IN |
denotes |
of |
T15380 |
61575-61578 |
DT |
denotes |
the |
T15381 |
61582-61586 |
NN |
denotes |
odor |
T15382 |
61579-61580 |
NN |
denotes |
S |
T15383 |
61580-61581 |
SYM |
denotes |
− |
T15384 |
61586-61587 |
. |
denotes |
. |
T15385 |
61587-61719 |
sentence |
denotes |
It was shown previously, however, that the detailed sampling pattern is a more sensitive measure of discrimination performance [3]. |
T15386 |
61588-61590 |
PRP |
denotes |
It |
T15387 |
61595-61600 |
VBN |
denotes |
shown |
T15388 |
61591-61594 |
VBD |
denotes |
was |
T15389 |
61601-61611 |
RB |
denotes |
previously |
T15390 |
61611-61613 |
, |
denotes |
, |
T15391 |
61613-61620 |
RB |
denotes |
however |
T15392 |
61620-61622 |
, |
denotes |
, |
T15393 |
61622-61626 |
IN |
denotes |
that |
T15394 |
61657-61659 |
VBZ |
denotes |
is |
T15395 |
61627-61630 |
DT |
denotes |
the |
T15396 |
61649-61656 |
NN |
denotes |
pattern |
T15397 |
61631-61639 |
JJ |
denotes |
detailed |
T15398 |
61640-61648 |
NN |
denotes |
sampling |
T15399 |
61660-61661 |
DT |
denotes |
a |
T15400 |
61677-61684 |
NN |
denotes |
measure |
T15401 |
61662-61666 |
RBR |
denotes |
more |
T15402 |
61667-61676 |
JJ |
denotes |
sensitive |
T15403 |
61685-61687 |
IN |
denotes |
of |
T15404 |
61688-61702 |
NN |
denotes |
discrimination |
T15405 |
61703-61714 |
NN |
denotes |
performance |
T15406 |
61715-61716 |
-LRB- |
denotes |
[ |
T15407 |
61716-61717 |
CD |
denotes |
3 |
T15408 |
61717-61718 |
-RRB- |
denotes |
] |
T15409 |
61718-61719 |
. |
denotes |
. |
T15410 |
61719-61866 |
sentence |
denotes |
To avoid long (> 3-week) training periods, we chose not to measure discrimination times [3] but to analyze the average sampling behavior in total. |
T15411 |
61720-61722 |
TO |
denotes |
To |
T15412 |
61723-61728 |
VB |
denotes |
avoid |
T15413 |
61766-61771 |
VBD |
denotes |
chose |
T15414 |
61729-61733 |
RB |
denotes |
long |
T15415 |
61754-61761 |
NNS |
denotes |
periods |
T15416 |
61734-61735 |
-LRB- |
denotes |
( |
T15417 |
61739-61743 |
NN |
denotes |
week |
T15418 |
61735-61736 |
SYM |
denotes |
> |
T15419 |
61737-61738 |
CD |
denotes |
3 |
T15420 |
61738-61739 |
HYPH |
denotes |
- |
T15421 |
61743-61744 |
-RRB- |
denotes |
) |
T15422 |
61745-61753 |
NN |
denotes |
training |
T15423 |
61761-61763 |
, |
denotes |
, |
T15424 |
61763-61765 |
PRP |
denotes |
we |
T15425 |
61772-61775 |
RB |
denotes |
not |
T15426 |
61779-61786 |
VB |
denotes |
measure |
T15427 |
61776-61778 |
TO |
denotes |
to |
T15428 |
61787-61801 |
NN |
denotes |
discrimination |
T15429 |
61802-61807 |
NNS |
denotes |
times |
T15430 |
61808-61809 |
-LRB- |
denotes |
[ |
T15431 |
61809-61810 |
CD |
denotes |
3 |
T15432 |
61810-61811 |
-RRB- |
denotes |
] |
T15433 |
61812-61815 |
CC |
denotes |
but |
T15434 |
61816-61818 |
TO |
denotes |
to |
T15435 |
61819-61826 |
VB |
denotes |
analyze |
T15436 |
61827-61830 |
DT |
denotes |
the |
T15437 |
61848-61856 |
NN |
denotes |
behavior |
T15438 |
61831-61838 |
JJ |
denotes |
average |
T15439 |
61839-61847 |
NN |
denotes |
sampling |
T15440 |
61857-61859 |
IN |
denotes |
in |
T15441 |
61860-61865 |
JJ |
denotes |
total |
T15442 |
61865-61866 |
. |
denotes |
. |
T15443 |
61866-62032 |
sentence |
denotes |
Upon presentation of a rewarded odor, the animal usually continuously breaks the beam, whereas upon presentation of an unrewarded odor the head is quickly retracted. |
T15444 |
61867-61871 |
IN |
denotes |
Upon |
T15445 |
61937-61943 |
VBZ |
denotes |
breaks |
T15446 |
61872-61884 |
NN |
denotes |
presentation |
T15447 |
61885-61887 |
IN |
denotes |
of |
T15448 |
61888-61889 |
DT |
denotes |
a |
T15449 |
61899-61903 |
NN |
denotes |
odor |
T15450 |
61890-61898 |
VBN |
denotes |
rewarded |
T15451 |
61903-61905 |
, |
denotes |
, |
T15452 |
61905-61908 |
DT |
denotes |
the |
T15453 |
61909-61915 |
NN |
denotes |
animal |
T15454 |
61916-61923 |
RB |
denotes |
usually |
T15455 |
61924-61936 |
RB |
denotes |
continuously |
T15456 |
61944-61947 |
DT |
denotes |
the |
T15457 |
61948-61952 |
NN |
denotes |
beam |
T15458 |
61952-61954 |
, |
denotes |
, |
T15459 |
61954-61961 |
IN |
denotes |
whereas |
T15460 |
62022-62031 |
VBN |
denotes |
retracted |
T15461 |
61962-61966 |
IN |
denotes |
upon |
T15462 |
61967-61979 |
NN |
denotes |
presentation |
T15463 |
61980-61982 |
IN |
denotes |
of |
T15464 |
61983-61985 |
DT |
denotes |
an |
T15465 |
61997-62001 |
NN |
denotes |
odor |
T15466 |
61986-61996 |
JJ |
denotes |
unrewarded |
T15467 |
62002-62005 |
DT |
denotes |
the |
T15468 |
62006-62010 |
NN |
denotes |
head |
T15469 |
62011-62013 |
VBZ |
denotes |
is |
T15470 |
62014-62021 |
RB |
denotes |
quickly |
T15471 |
62031-62032 |
. |
denotes |
. |
T15472 |
62032-62213 |
sentence |
denotes |
The difference in response to the rewarded and unrewarded odor is approximately sigmoidal (Figures 1D, 1E, and 2D) and yields a sensitive measure of the discrimination performance. |
T15473 |
62033-62036 |
DT |
denotes |
The |
T15474 |
62037-62047 |
NN |
denotes |
difference |
T15475 |
62096-62098 |
VBZ |
denotes |
is |
T15476 |
62048-62050 |
IN |
denotes |
in |
T15477 |
62051-62059 |
NN |
denotes |
response |
T15478 |
62060-62062 |
IN |
denotes |
to |
T15479 |
62063-62066 |
DT |
denotes |
the |
T15480 |
62091-62095 |
NN |
denotes |
odor |
T15481 |
62067-62075 |
VBN |
denotes |
rewarded |
T15482 |
62076-62079 |
CC |
denotes |
and |
T15483 |
62080-62090 |
JJ |
denotes |
unrewarded |
T15484 |
62099-62112 |
RB |
denotes |
approximately |
T15485 |
62113-62122 |
JJ |
denotes |
sigmoidal |
T15486 |
62123-62124 |
-LRB- |
denotes |
( |
T15487 |
62132-62134 |
NN |
denotes |
1D |
T15488 |
62124-62131 |
NNS |
denotes |
Figures |
T15489 |
62134-62136 |
, |
denotes |
, |
T15490 |
62136-62138 |
NN |
denotes |
1E |
T15491 |
62138-62140 |
, |
denotes |
, |
T15492 |
62140-62143 |
CC |
denotes |
and |
T15493 |
62144-62146 |
NN |
denotes |
2D |
T15494 |
62146-62147 |
-RRB- |
denotes |
) |
T15495 |
62148-62151 |
CC |
denotes |
and |
T15496 |
62152-62158 |
VBZ |
denotes |
yields |
T15497 |
62159-62160 |
DT |
denotes |
a |
T15498 |
62171-62178 |
NN |
denotes |
measure |
T15499 |
62161-62170 |
JJ |
denotes |
sensitive |
T15500 |
62179-62181 |
IN |
denotes |
of |
T15501 |
62182-62185 |
DT |
denotes |
the |
T15502 |
62201-62212 |
NN |
denotes |
performance |
T15503 |
62186-62200 |
NN |
denotes |
discrimination |
T15504 |
62212-62213 |
. |
denotes |
. |
T15505 |
62213-62440 |
sentence |
denotes |
From this difference or from a sigmoidal fit to the difference (Figure 1E), several measures of discrimination can be determined: the average difference, peak, or maximum, time of half maximum, and slope of the fitted sigmoid. |
T15506 |
62214-62218 |
IN |
denotes |
From |
T15507 |
62332-62342 |
VBN |
denotes |
determined |
T15508 |
62219-62223 |
DT |
denotes |
this |
T15509 |
62224-62234 |
NN |
denotes |
difference |
T15510 |
62235-62237 |
CC |
denotes |
or |
T15511 |
62238-62242 |
IN |
denotes |
from |
T15512 |
62243-62244 |
DT |
denotes |
a |
T15513 |
62255-62258 |
NN |
denotes |
fit |
T15514 |
62245-62254 |
JJ |
denotes |
sigmoidal |
T15515 |
62259-62261 |
IN |
denotes |
to |
T15516 |
62262-62265 |
DT |
denotes |
the |
T15517 |
62266-62276 |
NN |
denotes |
difference |
T15518 |
62277-62278 |
-LRB- |
denotes |
( |
T15519 |
62285-62287 |
NN |
denotes |
1E |
T15520 |
62278-62284 |
NN |
denotes |
Figure |
T15521 |
62287-62288 |
-RRB- |
denotes |
) |
T15522 |
62288-62290 |
, |
denotes |
, |
T15523 |
62290-62297 |
JJ |
denotes |
several |
T15524 |
62298-62306 |
NNS |
denotes |
measures |
T15525 |
62307-62309 |
IN |
denotes |
of |
T15526 |
62310-62324 |
NN |
denotes |
discrimination |
T15527 |
62325-62328 |
MD |
denotes |
can |
T15528 |
62329-62331 |
VB |
denotes |
be |
T15529 |
62342-62344 |
: |
denotes |
: |
T15530 |
62344-62347 |
DT |
denotes |
the |
T15531 |
62356-62366 |
NN |
denotes |
difference |
T15532 |
62348-62355 |
JJ |
denotes |
average |
T15533 |
62366-62368 |
, |
denotes |
, |
T15534 |
62368-62372 |
NN |
denotes |
peak |
T15535 |
62386-62390 |
NN |
denotes |
time |
T15536 |
62372-62374 |
, |
denotes |
, |
T15537 |
62374-62376 |
CC |
denotes |
or |
T15538 |
62377-62384 |
NN |
denotes |
maximum |
T15539 |
62384-62386 |
, |
denotes |
, |
T15540 |
62391-62393 |
IN |
denotes |
of |
T15541 |
62394-62398 |
JJ |
denotes |
half |
T15542 |
62399-62406 |
NN |
denotes |
maximum |
T15543 |
62406-62408 |
, |
denotes |
, |
T15544 |
62408-62411 |
CC |
denotes |
and |
T15545 |
62412-62417 |
NN |
denotes |
slope |
T15546 |
62418-62420 |
IN |
denotes |
of |
T15547 |
62421-62424 |
DT |
denotes |
the |
T15548 |
62432-62439 |
NN |
denotes |
sigmoid |
T15549 |
62425-62431 |
VBN |
denotes |
fitted |
T15550 |
62439-62440 |
. |
denotes |
. |
T15551 |
62440-62587 |
sentence |
denotes |
Whereas for small trial numbers (< 200) the slope often is not well constrained, any of the other parameters yielded essentially the same results. |
T15552 |
62441-62448 |
IN |
denotes |
Whereas |
T15553 |
62497-62499 |
VBZ |
denotes |
is |
T15554 |
62449-62452 |
IN |
denotes |
for |
T15555 |
62453-62458 |
JJ |
denotes |
small |
T15556 |
62465-62472 |
NNS |
denotes |
numbers |
T15557 |
62459-62464 |
NN |
denotes |
trial |
T15558 |
62473-62474 |
-LRB- |
denotes |
( |
T15559 |
62476-62479 |
CD |
denotes |
200 |
T15560 |
62474-62475 |
SYM |
denotes |
< |
T15561 |
62479-62480 |
-RRB- |
denotes |
) |
T15562 |
62481-62484 |
DT |
denotes |
the |
T15563 |
62485-62490 |
NN |
denotes |
slope |
T15564 |
62491-62496 |
RB |
denotes |
often |
T15565 |
62550-62557 |
VBD |
denotes |
yielded |
T15566 |
62500-62503 |
RB |
denotes |
not |
T15567 |
62504-62508 |
RB |
denotes |
well |
T15568 |
62509-62520 |
VBN |
denotes |
constrained |
T15569 |
62520-62522 |
, |
denotes |
, |
T15570 |
62522-62525 |
DT |
denotes |
any |
T15571 |
62526-62528 |
IN |
denotes |
of |
T15572 |
62529-62532 |
DT |
denotes |
the |
T15573 |
62539-62549 |
NNS |
denotes |
parameters |
T15574 |
62533-62538 |
JJ |
denotes |
other |
T15575 |
62558-62569 |
RB |
denotes |
essentially |
T15576 |
62570-62573 |
DT |
denotes |
the |
T15577 |
62579-62586 |
NNS |
denotes |
results |
T15578 |
62574-62578 |
JJ |
denotes |
same |
T15579 |
62586-62587 |
. |
denotes |
. |
T15580 |
62587-62756 |
sentence |
denotes |
The discrimination index plotted in Figures 1F, 2C, 4D, and 6C refers to the fitted maximum, generally ranging from zero to one, one indicating the best discrimination. |
T15581 |
62588-62591 |
DT |
denotes |
The |
T15582 |
62607-62612 |
NN |
denotes |
index |
T15583 |
62592-62606 |
NN |
denotes |
discrimination |
T15584 |
62651-62657 |
VBZ |
denotes |
refers |
T15585 |
62613-62620 |
VBN |
denotes |
plotted |
T15586 |
62621-62623 |
IN |
denotes |
in |
T15587 |
62624-62631 |
NNS |
denotes |
Figures |
T15588 |
62632-62634 |
NN |
denotes |
1F |
T15589 |
62634-62636 |
, |
denotes |
, |
T15590 |
62636-62638 |
NN |
denotes |
2C |
T15591 |
62638-62640 |
, |
denotes |
, |
T15592 |
62640-62642 |
NN |
denotes |
4D |
T15593 |
62642-62644 |
, |
denotes |
, |
T15594 |
62644-62647 |
CC |
denotes |
and |
T15595 |
62648-62650 |
NN |
denotes |
6C |
T15596 |
62658-62660 |
IN |
denotes |
to |
T15597 |
62661-62664 |
DT |
denotes |
the |
T15598 |
62672-62679 |
NN |
denotes |
maximum |
T15599 |
62665-62671 |
VBN |
denotes |
fitted |
T15600 |
62679-62681 |
, |
denotes |
, |
T15601 |
62681-62690 |
RB |
denotes |
generally |
T15602 |
62691-62698 |
VBG |
denotes |
ranging |
T15603 |
62699-62703 |
IN |
denotes |
from |
T15604 |
62704-62708 |
CD |
denotes |
zero |
T15605 |
62709-62711 |
IN |
denotes |
to |
T15606 |
62712-62715 |
CD |
denotes |
one |
T15607 |
62715-62717 |
, |
denotes |
, |
T15608 |
62717-62720 |
CD |
denotes |
one |
T15609 |
62721-62731 |
VBG |
denotes |
indicating |
T15610 |
62732-62735 |
DT |
denotes |
the |
T15611 |
62741-62755 |
NN |
denotes |
discrimination |
T15612 |
62736-62740 |
JJS |
denotes |
best |
T15613 |
62755-62756 |
. |
denotes |
. |
T15614 |
62756-62868 |
sentence |
denotes |
Identical results were obtained with other measures of discrimination, such as the average sampling difference. |
T15615 |
62757-62766 |
JJ |
denotes |
Identical |
T15616 |
62767-62774 |
NNS |
denotes |
results |
T15617 |
62780-62788 |
VBN |
denotes |
obtained |
T15618 |
62775-62779 |
VBD |
denotes |
were |
T15619 |
62789-62793 |
IN |
denotes |
with |
T15620 |
62794-62799 |
JJ |
denotes |
other |
T15621 |
62800-62808 |
NNS |
denotes |
measures |
T15622 |
62809-62811 |
IN |
denotes |
of |
T15623 |
62812-62826 |
NN |
denotes |
discrimination |
T15624 |
62826-62828 |
, |
denotes |
, |
T15625 |
62828-62832 |
JJ |
denotes |
such |
T15626 |
62833-62835 |
IN |
denotes |
as |
T15627 |
62836-62839 |
DT |
denotes |
the |
T15628 |
62857-62867 |
NN |
denotes |
difference |
T15629 |
62840-62847 |
JJ |
denotes |
average |
T15630 |
62848-62856 |
NN |
denotes |
sampling |
T15631 |
62867-62868 |
. |
denotes |
. |
T15659 |
62870-62879 |
NN |
denotes |
Structure |
T15660 |
62880-62882 |
IN |
denotes |
of |
T15661 |
62883-62891 |
NN |
denotes |
training |
T15662 |
62891-62997 |
sentence |
denotes |
After habituation, mice were trained to discriminate 1% amylacetate from 1% ethylbutyrate for 500 trials. |
T15663 |
62892-62897 |
IN |
denotes |
After |
T15664 |
62921-62928 |
VBN |
denotes |
trained |
T15665 |
62898-62909 |
NN |
denotes |
habituation |
T15666 |
62909-62911 |
, |
denotes |
, |
T15667 |
62911-62915 |
NNS |
denotes |
mice |
T15668 |
62916-62920 |
VBD |
denotes |
were |
T15669 |
62929-62931 |
TO |
denotes |
to |
T15670 |
62932-62944 |
VB |
denotes |
discriminate |
T15671 |
62945-62946 |
CD |
denotes |
1 |
T15672 |
62946-62947 |
NN |
denotes |
% |
T15673 |
62948-62959 |
NN |
denotes |
amylacetate |
T15674 |
62960-62964 |
IN |
denotes |
from |
T15675 |
62965-62966 |
CD |
denotes |
1 |
T15676 |
62966-62967 |
NN |
denotes |
% |
T15677 |
62968-62981 |
NN |
denotes |
ethylbutyrate |
T15678 |
62982-62985 |
IN |
denotes |
for |
T15679 |
62986-62989 |
CD |
denotes |
500 |
T15680 |
62990-62996 |
NNS |
denotes |
trials |
T15681 |
62996-62997 |
. |
denotes |
. |
T15682 |
62997-63140 |
sentence |
denotes |
During the last 100 trials, the S+ odor was rewarded in only 50% of the cases to increase the resistance to extinction of the acquired memory. |
T15683 |
62998-63004 |
IN |
denotes |
During |
T15684 |
63042-63050 |
VBN |
denotes |
rewarded |
T15685 |
63005-63008 |
DT |
denotes |
the |
T15686 |
63018-63024 |
NNS |
denotes |
trials |
T15687 |
63009-63013 |
JJ |
denotes |
last |
T15688 |
63014-63017 |
CD |
denotes |
100 |
T15689 |
63024-63026 |
, |
denotes |
, |
T15690 |
63026-63029 |
DT |
denotes |
the |
T15691 |
63033-63037 |
NN |
denotes |
odor |
T15692 |
63030-63031 |
NN |
denotes |
S |
T15693 |
63031-63032 |
SYM |
denotes |
+ |
T15694 |
63038-63041 |
VBD |
denotes |
was |
T15695 |
63051-63053 |
IN |
denotes |
in |
T15696 |
63054-63058 |
RB |
denotes |
only |
T15697 |
63059-63061 |
CD |
denotes |
50 |
T15698 |
63061-63062 |
NN |
denotes |
% |
T15699 |
63063-63065 |
IN |
denotes |
of |
T15700 |
63066-63069 |
DT |
denotes |
the |
T15701 |
63070-63075 |
NNS |
denotes |
cases |
T15702 |
63076-63078 |
TO |
denotes |
to |
T15703 |
63079-63087 |
VB |
denotes |
increase |
T15704 |
63088-63091 |
DT |
denotes |
the |
T15705 |
63092-63102 |
NN |
denotes |
resistance |
T15706 |
63103-63105 |
IN |
denotes |
to |
T15707 |
63106-63116 |
NN |
denotes |
extinction |
T15708 |
63117-63119 |
IN |
denotes |
of |
T15709 |
63120-63123 |
DT |
denotes |
the |
T15710 |
63133-63139 |
NN |
denotes |
memory |
T15711 |
63124-63132 |
VBN |
denotes |
acquired |
T15712 |
63139-63140 |
. |
denotes |
. |
T15713 |
63140-63220 |
sentence |
denotes |
These trials were excluded for the statistical analysis of the learning curves. |
T15714 |
63141-63146 |
DT |
denotes |
These |
T15715 |
63147-63153 |
NNS |
denotes |
trials |
T15716 |
63159-63167 |
VBN |
denotes |
excluded |
T15717 |
63154-63158 |
VBD |
denotes |
were |
T15718 |
63168-63171 |
IN |
denotes |
for |
T15719 |
63172-63175 |
DT |
denotes |
the |
T15720 |
63188-63196 |
NN |
denotes |
analysis |
T15721 |
63176-63187 |
JJ |
denotes |
statistical |
T15722 |
63197-63199 |
IN |
denotes |
of |
T15723 |
63200-63203 |
DT |
denotes |
the |
T15724 |
63213-63219 |
NNS |
denotes |
curves |
T15725 |
63204-63212 |
NN |
denotes |
learning |
T15726 |
63219-63220 |
. |
denotes |
. |
T15727 |
63220-63411 |
sentence |
denotes |
Inclusion did not alter the result of the ANOVA; however, linear fitting of the learning curve was not appropriate anymore as partial saturation of learning performance had already occurred. |
T15728 |
63221-63230 |
NN |
denotes |
Inclusion |
T15729 |
63239-63244 |
VB |
denotes |
alter |
T15730 |
63231-63234 |
VBD |
denotes |
did |
T15731 |
63235-63238 |
RB |
denotes |
not |
T15732 |
63316-63319 |
VBD |
denotes |
was |
T15733 |
63245-63248 |
DT |
denotes |
the |
T15734 |
63249-63255 |
NN |
denotes |
result |
T15735 |
63256-63258 |
IN |
denotes |
of |
T15736 |
63259-63262 |
DT |
denotes |
the |
T15737 |
63263-63268 |
NN |
denotes |
ANOVA |
T15738 |
63268-63269 |
: |
denotes |
; |
T15739 |
63270-63277 |
RB |
denotes |
however |
T15740 |
63277-63279 |
, |
denotes |
, |
T15741 |
63279-63285 |
JJ |
denotes |
linear |
T15742 |
63286-63293 |
NN |
denotes |
fitting |
T15743 |
63294-63296 |
IN |
denotes |
of |
T15744 |
63297-63300 |
DT |
denotes |
the |
T15745 |
63310-63315 |
NN |
denotes |
curve |
T15746 |
63301-63309 |
NN |
denotes |
learning |
T15747 |
63320-63323 |
RB |
denotes |
not |
T15748 |
63324-63335 |
JJ |
denotes |
appropriate |
T15749 |
63336-63343 |
RB |
denotes |
anymore |
T15750 |
63344-63346 |
IN |
denotes |
as |
T15751 |
63402-63410 |
VBN |
denotes |
occurred |
T15752 |
63347-63354 |
JJ |
denotes |
partial |
T15753 |
63355-63365 |
NN |
denotes |
saturation |
T15754 |
63366-63368 |
IN |
denotes |
of |
T15755 |
63369-63377 |
NN |
denotes |
learning |
T15756 |
63378-63389 |
NN |
denotes |
performance |
T15757 |
63390-63393 |
VBD |
denotes |
had |
T15758 |
63394-63401 |
RB |
denotes |
already |
T15759 |
63410-63411 |
. |
denotes |
. |
T15760 |
63411-63587 |
sentence |
denotes |
Subsequently, animals were trained for 500 trials on the “difficult” discrimination task [3] between the binary mixtures 0.6% eugenol/0.4% cineol and 0.4% eugenol/0.6% cineol. |
T15761 |
63412-63424 |
RB |
denotes |
Subsequently |
T15762 |
63439-63446 |
VBN |
denotes |
trained |
T15763 |
63424-63426 |
, |
denotes |
, |
T15764 |
63426-63433 |
NNS |
denotes |
animals |
T15765 |
63434-63438 |
VBD |
denotes |
were |
T15766 |
63447-63450 |
IN |
denotes |
for |
T15767 |
63451-63454 |
CD |
denotes |
500 |
T15768 |
63455-63461 |
NNS |
denotes |
trials |
T15769 |
63462-63464 |
IN |
denotes |
on |
T15770 |
63465-63468 |
DT |
denotes |
the |
T15771 |
63496-63500 |
NN |
denotes |
task |
T15772 |
63469-63470 |
`` |
denotes |
“ |
T15773 |
63470-63479 |
JJ |
denotes |
difficult |
T15774 |
63479-63480 |
'' |
denotes |
” |
T15775 |
63481-63495 |
NN |
denotes |
discrimination |
T15776 |
63501-63502 |
-LRB- |
denotes |
[ |
T15777 |
63502-63503 |
CD |
denotes |
3 |
T15778 |
63503-63504 |
-RRB- |
denotes |
] |
T15779 |
63505-63512 |
IN |
denotes |
between |
T15780 |
63513-63516 |
DT |
denotes |
the |
T15781 |
63524-63532 |
NNS |
denotes |
mixtures |
T15782 |
63517-63523 |
JJ |
denotes |
binary |
T15783 |
63533-63536 |
CD |
denotes |
0.6 |
T15784 |
63536-63537 |
NN |
denotes |
% |
T15785 |
63538-63545 |
NN |
denotes |
eugenol |
T15786 |
63545-63546 |
HYPH |
denotes |
/ |
T15787 |
63546-63549 |
CD |
denotes |
0.4 |
T15788 |
63549-63550 |
NN |
denotes |
% |
T15789 |
63551-63557 |
NN |
denotes |
cineol |
T15790 |
63558-63561 |
CC |
denotes |
and |
T15791 |
63562-63565 |
CD |
denotes |
0.4 |
T15792 |
63565-63566 |
NN |
denotes |
% |
T15793 |
63567-63574 |
NN |
denotes |
eugenol |
T15794 |
63574-63575 |
HYPH |
denotes |
/ |
T15795 |
63575-63578 |
CD |
denotes |
0.6 |
T15796 |
63578-63579 |
NN |
denotes |
% |
T15797 |
63580-63586 |
NN |
denotes |
cineol |
T15798 |
63586-63587 |
. |
denotes |
. |
T15799 |
63587-63688 |
sentence |
denotes |
To allow comparison, the last 100 trials were altered as for the “simple” discrimination task above. |
T15800 |
63588-63590 |
TO |
denotes |
To |
T15801 |
63591-63596 |
VB |
denotes |
allow |
T15802 |
63634-63641 |
VBN |
denotes |
altered |
T15803 |
63597-63607 |
NN |
denotes |
comparison |
T15804 |
63607-63609 |
, |
denotes |
, |
T15805 |
63609-63612 |
DT |
denotes |
the |
T15806 |
63622-63628 |
NNS |
denotes |
trials |
T15807 |
63613-63617 |
JJ |
denotes |
last |
T15808 |
63618-63621 |
CD |
denotes |
100 |
T15809 |
63629-63633 |
VBD |
denotes |
were |
T15810 |
63642-63644 |
IN |
denotes |
as |
T15811 |
63645-63648 |
IN |
denotes |
for |
T15812 |
63649-63652 |
DT |
denotes |
the |
T15813 |
63677-63681 |
NN |
denotes |
task |
T15814 |
63653-63654 |
`` |
denotes |
“ |
T15815 |
63654-63660 |
JJ |
denotes |
simple |
T15816 |
63660-63661 |
'' |
denotes |
” |
T15817 |
63662-63676 |
NN |
denotes |
discrimination |
T15818 |
63682-63687 |
RB |
denotes |
above |
T15819 |
63687-63688 |
. |
denotes |
. |
T15820 |
63688-63848 |
sentence |
denotes |
After two days of rest, animals were finally trained on the “simple” discrimination task between 1% pelargonic acid and 1% valeric acid for another 600 trials. |
T15821 |
63689-63694 |
IN |
denotes |
After |
T15822 |
63734-63741 |
VBN |
denotes |
trained |
T15823 |
63695-63698 |
CD |
denotes |
two |
T15824 |
63699-63703 |
NNS |
denotes |
days |
T15825 |
63704-63706 |
IN |
denotes |
of |
T15826 |
63707-63711 |
NN |
denotes |
rest |
T15827 |
63711-63713 |
, |
denotes |
, |
T15828 |
63713-63720 |
NNS |
denotes |
animals |
T15829 |
63721-63725 |
VBD |
denotes |
were |
T15830 |
63726-63733 |
RB |
denotes |
finally |
T15831 |
63742-63744 |
IN |
denotes |
on |
T15832 |
63745-63748 |
DT |
denotes |
the |
T15833 |
63773-63777 |
NN |
denotes |
task |
T15834 |
63749-63750 |
`` |
denotes |
“ |
T15835 |
63750-63756 |
JJ |
denotes |
simple |
T15836 |
63756-63757 |
'' |
denotes |
” |
T15837 |
63758-63772 |
NN |
denotes |
discrimination |
T15838 |
63778-63785 |
IN |
denotes |
between |
T15839 |
63786-63787 |
CD |
denotes |
1 |
T15840 |
63787-63788 |
NN |
denotes |
% |
T15841 |
63800-63804 |
NN |
denotes |
acid |
T15842 |
63789-63799 |
JJ |
denotes |
pelargonic |
T15843 |
63805-63808 |
CC |
denotes |
and |
T15844 |
63809-63810 |
CD |
denotes |
1 |
T15845 |
63810-63811 |
NN |
denotes |
% |
T15846 |
63820-63824 |
NN |
denotes |
acid |
T15847 |
63812-63819 |
JJ |
denotes |
valeric |
T15848 |
63825-63828 |
IN |
denotes |
for |
T15849 |
63829-63836 |
DT |
denotes |
another |
T15850 |
63841-63847 |
NNS |
denotes |
trials |
T15851 |
63837-63840 |
CD |
denotes |
600 |
T15852 |
63847-63848 |
. |
denotes |
. |
T15853 |
63848-64066 |
sentence |
denotes |
In all experiments, counterbalancing between both odors and setups was ensured within and between genetic groups, or results were compared with counterbalanced subgroups, which in every case yielded identical results. |
T15854 |
63849-63851 |
IN |
denotes |
In |
T15855 |
63920-63927 |
VBN |
denotes |
ensured |
T15856 |
63852-63855 |
DT |
denotes |
all |
T15857 |
63856-63867 |
NNS |
denotes |
experiments |
T15858 |
63867-63869 |
, |
denotes |
, |
T15860 |
63886-63893 |
IN |
denotes |
between |
T15861 |
63894-63898 |
DT |
denotes |
both |
T15862 |
63899-63904 |
NNS |
denotes |
odors |
T15863 |
63905-63908 |
CC |
denotes |
and |
T15864 |
63909-63915 |
NNS |
denotes |
setups |
T15865 |
63916-63919 |
VBD |
denotes |
was |
T15866 |
63928-63934 |
IN |
denotes |
within |
T15867 |
63935-63938 |
CC |
denotes |
and |
T15868 |
63939-63946 |
IN |
denotes |
between |
T15869 |
63947-63954 |
JJ |
denotes |
genetic |
T15870 |
63955-63961 |
NNS |
denotes |
groups |
T15871 |
63961-63963 |
, |
denotes |
, |
T15872 |
63963-63965 |
CC |
denotes |
or |
T15873 |
63966-63973 |
NNS |
denotes |
results |
T15874 |
63979-63987 |
VBN |
denotes |
compared |
T15875 |
63974-63978 |
VBD |
denotes |
were |
T15876 |
63988-63992 |
IN |
denotes |
with |
T15877 |
63993-64008 |
VBN |
denotes |
counterbalanced |
T15878 |
64009-64018 |
NNS |
denotes |
subgroups |
T15879 |
64018-64020 |
, |
denotes |
, |
T15880 |
64020-64025 |
WDT |
denotes |
which |
T15881 |
64040-64047 |
VBD |
denotes |
yielded |
T15882 |
64026-64028 |
IN |
denotes |
in |
T15883 |
64029-64034 |
DT |
denotes |
every |
T15884 |
64035-64039 |
NN |
denotes |
case |
T15885 |
64048-64057 |
JJ |
denotes |
identical |
T15886 |
64058-64065 |
NNS |
denotes |
results |
T15887 |
64065-64066 |
. |
denotes |
. |
T15888 |
64066-64213 |
sentence |
denotes |
During the entire course of the experiment, the person handling the animals and operating the olfactometers was blind to the genotype of the mice. |
T15889 |
64067-64073 |
IN |
denotes |
During |
T15890 |
64175-64178 |
VBD |
denotes |
was |
T15891 |
64074-64077 |
DT |
denotes |
the |
T15892 |
64085-64091 |
NN |
denotes |
course |
T15893 |
64078-64084 |
JJ |
denotes |
entire |
T15894 |
64092-64094 |
IN |
denotes |
of |
T15895 |
64095-64098 |
DT |
denotes |
the |
T15896 |
64099-64109 |
NN |
denotes |
experiment |
T15897 |
64109-64111 |
, |
denotes |
, |
T15898 |
64111-64114 |
DT |
denotes |
the |
T15899 |
64115-64121 |
NN |
denotes |
person |
T15900 |
64122-64130 |
VBG |
denotes |
handling |
T15901 |
64131-64134 |
DT |
denotes |
the |
T15902 |
64135-64142 |
NNS |
denotes |
animals |
T15903 |
64143-64146 |
CC |
denotes |
and |
T15904 |
64147-64156 |
VBG |
denotes |
operating |
T15905 |
64157-64160 |
DT |
denotes |
the |
T15906 |
64161-64174 |
NNS |
denotes |
olfactometers |
T15907 |
64179-64184 |
JJ |
denotes |
blind |
T15908 |
64185-64187 |
IN |
denotes |
to |
T15909 |
64188-64191 |
DT |
denotes |
the |
T15910 |
64192-64200 |
NN |
denotes |
genotype |
T15911 |
64201-64203 |
IN |
denotes |
of |
T15912 |
64204-64207 |
DT |
denotes |
the |
T15913 |
64208-64212 |
NNS |
denotes |
mice |
T15914 |
64212-64213 |
. |
denotes |
. |
T15964 |
64215-64221 |
NN |
denotes |
Memory |
T15965 |
64222-64233 |
NN |
denotes |
measurement |
T15966 |
64233-64507 |
sentence |
denotes |
To assess memory, after 280 trials of training to discriminate between pelargonic acid and valeric acid, memory trials were interleaved for 120 trials; that is, within each block of 20 trials two unrewarded amylacetate and two unrewarded ethylbutyrate trials were included. |
T15967 |
64234-64236 |
TO |
denotes |
To |
T15968 |
64237-64243 |
VB |
denotes |
assess |
T15969 |
64358-64369 |
VBN |
denotes |
interleaved |
T15970 |
64244-64250 |
NN |
denotes |
memory |
T15971 |
64250-64252 |
, |
denotes |
, |
T15972 |
64252-64257 |
IN |
denotes |
after |
T15973 |
64258-64261 |
CD |
denotes |
280 |
T15974 |
64262-64268 |
NNS |
denotes |
trials |
T15975 |
64269-64271 |
IN |
denotes |
of |
T15976 |
64272-64280 |
NN |
denotes |
training |
T15977 |
64281-64283 |
TO |
denotes |
to |
T15978 |
64284-64296 |
VB |
denotes |
discriminate |
T15979 |
64297-64304 |
IN |
denotes |
between |
T15980 |
64305-64315 |
JJ |
denotes |
pelargonic |
T15981 |
64316-64320 |
NN |
denotes |
acid |
T15982 |
64321-64324 |
CC |
denotes |
and |
T15983 |
64325-64332 |
JJ |
denotes |
valeric |
T15984 |
64333-64337 |
NN |
denotes |
acid |
T15985 |
64337-64339 |
, |
denotes |
, |
T15986 |
64339-64345 |
NN |
denotes |
memory |
T15987 |
64346-64352 |
NNS |
denotes |
trials |
T15988 |
64353-64357 |
VBD |
denotes |
were |
T15989 |
64498-64506 |
VBN |
denotes |
included |
T15990 |
64370-64373 |
IN |
denotes |
for |
T15991 |
64374-64377 |
CD |
denotes |
120 |
T15992 |
64378-64384 |
NNS |
denotes |
trials |
T15993 |
64384-64385 |
: |
denotes |
; |
T15994 |
64386-64390 |
RB |
denotes |
that |
T15995 |
64391-64393 |
RB |
denotes |
is |
T15996 |
64393-64395 |
, |
denotes |
, |
T15997 |
64395-64401 |
IN |
denotes |
within |
T15998 |
64402-64406 |
DT |
denotes |
each |
T15999 |
64407-64412 |
NN |
denotes |
block |
T16000 |
64413-64415 |
IN |
denotes |
of |
T16001 |
64416-64418 |
CD |
denotes |
20 |
T16002 |
64419-64425 |
NNS |
denotes |
trials |
T16003 |
64426-64429 |
CD |
denotes |
two |
T16004 |
64441-64452 |
NN |
denotes |
amylacetate |
T16005 |
64430-64440 |
JJ |
denotes |
unrewarded |
T16006 |
64453-64456 |
CC |
denotes |
and |
T16007 |
64457-64460 |
CD |
denotes |
two |
T16008 |
64472-64485 |
NN |
denotes |
ethylbutyrate |
T16009 |
64461-64471 |
JJ |
denotes |
unrewarded |
T16010 |
64486-64492 |
NNS |
denotes |
trials |
T16011 |
64493-64497 |
VBD |
denotes |
were |
T16012 |
64506-64507 |
. |
denotes |
. |
T16013 |
64507-64758 |
sentence |
denotes |
Memory scores are given as the fraction of those unrewarded trials that were responded to “correctly” (licking response to the odor that was rewarded in the initial training session [S+], no response to the odor that was not rewarded initially [S−]). |
T16014 |
64508-64514 |
NN |
denotes |
Memory |
T16015 |
64515-64521 |
NNS |
denotes |
scores |
T16016 |
64526-64531 |
VBN |
denotes |
given |
T16017 |
64522-64525 |
VBP |
denotes |
are |
T16018 |
64532-64534 |
IN |
denotes |
as |
T16019 |
64535-64538 |
DT |
denotes |
the |
T16020 |
64539-64547 |
NN |
denotes |
fraction |
T16021 |
64548-64550 |
IN |
denotes |
of |
T16022 |
64551-64556 |
DT |
denotes |
those |
T16023 |
64568-64574 |
NNS |
denotes |
trials |
T16024 |
64557-64567 |
JJ |
denotes |
unrewarded |
T16025 |
64575-64579 |
WDT |
denotes |
that |
T16026 |
64585-64594 |
VBN |
denotes |
responded |
T16027 |
64580-64584 |
VBD |
denotes |
were |
T16028 |
64595-64597 |
IN |
denotes |
to |
T16029 |
64598-64599 |
`` |
denotes |
“ |
T16030 |
64599-64608 |
RB |
denotes |
correctly |
T16031 |
64608-64609 |
'' |
denotes |
” |
T16032 |
64610-64611 |
-LRB- |
denotes |
( |
T16033 |
64699-64707 |
NN |
denotes |
response |
T16034 |
64611-64618 |
NN |
denotes |
licking |
T16035 |
64619-64627 |
NN |
denotes |
response |
T16036 |
64628-64630 |
IN |
denotes |
to |
T16037 |
64631-64634 |
DT |
denotes |
the |
T16038 |
64635-64639 |
NN |
denotes |
odor |
T16039 |
64640-64644 |
WDT |
denotes |
that |
T16040 |
64649-64657 |
VBN |
denotes |
rewarded |
T16041 |
64645-64648 |
VBD |
denotes |
was |
T16042 |
64658-64660 |
IN |
denotes |
in |
T16043 |
64661-64664 |
DT |
denotes |
the |
T16044 |
64682-64689 |
NN |
denotes |
session |
T16045 |
64665-64672 |
JJ |
denotes |
initial |
T16046 |
64673-64681 |
NN |
denotes |
training |
T16047 |
64690-64691 |
-LRB- |
denotes |
[ |
T16048 |
64691-64692 |
NN |
denotes |
S |
T16049 |
64692-64693 |
SYM |
denotes |
+ |
T16050 |
64693-64694 |
-RRB- |
denotes |
] |
T16051 |
64694-64696 |
, |
denotes |
, |
T16052 |
64696-64698 |
DT |
denotes |
no |
T16053 |
64708-64710 |
IN |
denotes |
to |
T16054 |
64711-64714 |
DT |
denotes |
the |
T16055 |
64715-64719 |
NN |
denotes |
odor |
T16056 |
64720-64724 |
WDT |
denotes |
that |
T16057 |
64733-64741 |
VBN |
denotes |
rewarded |
T16058 |
64725-64728 |
VBD |
denotes |
was |
T16059 |
64729-64732 |
RB |
denotes |
not |
T16060 |
64742-64751 |
RB |
denotes |
initially |
T16061 |
64752-64753 |
-LRB- |
denotes |
[ |
T16062 |
64753-64754 |
NN |
denotes |
S |
T16063 |
64754-64755 |
SYM |
denotes |
− |
T16064 |
64755-64756 |
-RRB- |
denotes |
] |
T16065 |
64756-64757 |
-RRB- |
denotes |
) |
T16066 |
64757-64758 |
. |
denotes |
. |
T16067 |
64758-64906 |
sentence |
denotes |
Due to the epileptic phenotype and the slightly increased mortality [58], GluRBΔECS:FB mice were trained only for the initial period of 400 trials. |
T16068 |
64759-64762 |
IN |
denotes |
Due |
T16069 |
64856-64863 |
VBN |
denotes |
trained |
T16070 |
64763-64765 |
IN |
denotes |
to |
T16071 |
64766-64769 |
DT |
denotes |
the |
T16072 |
64780-64789 |
NN |
denotes |
phenotype |
T16073 |
64770-64779 |
JJ |
denotes |
epileptic |
T16074 |
64790-64793 |
CC |
denotes |
and |
T16075 |
64794-64797 |
DT |
denotes |
the |
T16076 |
64817-64826 |
NN |
denotes |
mortality |
T16077 |
64798-64806 |
RB |
denotes |
slightly |
T16078 |
64807-64816 |
VBN |
denotes |
increased |
T16079 |
64827-64828 |
-LRB- |
denotes |
[ |
T16080 |
64828-64830 |
CD |
denotes |
58 |
T16081 |
64830-64831 |
-RRB- |
denotes |
] |
T16082 |
64831-64833 |
, |
denotes |
, |
T16083 |
64833-64842 |
NN |
denotes |
GluRBΔECS |
T16084 |
64843-64845 |
NN |
denotes |
FB |
T16085 |
64842-64843 |
: |
denotes |
: |
T16086 |
64846-64850 |
NNS |
denotes |
mice |
T16087 |
64851-64855 |
VBD |
denotes |
were |
T16088 |
64864-64868 |
RB |
denotes |
only |
T16089 |
64869-64872 |
IN |
denotes |
for |
T16090 |
64873-64876 |
DT |
denotes |
the |
T16091 |
64885-64891 |
NN |
denotes |
period |
T16092 |
64877-64884 |
JJ |
denotes |
initial |
T16093 |
64892-64894 |
IN |
denotes |
of |
T16094 |
64895-64898 |
CD |
denotes |
400 |
T16095 |
64899-64905 |
NNS |
denotes |
trials |
T16096 |
64905-64906 |
. |
denotes |
. |
T16133 |
64908-64918 |
NN |
denotes |
Statistics |
T16134 |
64918-65062 |
sentence |
denotes |
Learning curves for both correct performance (“percentage correct”) and the discrimination performance were analyzed by repeated measure ANOVA. |
T16135 |
64919-64927 |
NN |
denotes |
Learning |
T16136 |
64928-64934 |
NNS |
denotes |
curves |
T16137 |
65027-65035 |
VBN |
denotes |
analyzed |
T16138 |
64935-64938 |
IN |
denotes |
for |
T16139 |
64939-64943 |
CC |
denotes |
both |
T16140 |
64952-64963 |
NN |
denotes |
performance |
T16141 |
64944-64951 |
JJ |
denotes |
correct |
T16142 |
64964-64965 |
-LRB- |
denotes |
( |
T16143 |
64966-64976 |
NN |
denotes |
percentage |
T16144 |
64965-64966 |
`` |
denotes |
“ |
T16145 |
64977-64984 |
JJ |
denotes |
correct |
T16146 |
64984-64985 |
'' |
denotes |
” |
T16147 |
64985-64986 |
-RRB- |
denotes |
) |
T16148 |
64987-64990 |
CC |
denotes |
and |
T16149 |
64991-64994 |
DT |
denotes |
the |
T16150 |
65010-65021 |
NN |
denotes |
performance |
T16151 |
64995-65009 |
NN |
denotes |
discrimination |
T16152 |
65022-65026 |
VBD |
denotes |
were |
T16153 |
65036-65038 |
IN |
denotes |
by |
T16154 |
65039-65047 |
VBN |
denotes |
repeated |
T16155 |
65048-65055 |
NN |
denotes |
measure |
T16156 |
65056-65061 |
NN |
denotes |
ANOVA |
T16157 |
65061-65062 |
. |
denotes |
. |
T16158 |
65062-65213 |
sentence |
denotes |
Additionally, learning curves were assessed by linearly fitting of trend lines to the data with fixed offsets, leaving the slope as the only variable. |
T16159 |
65063-65075 |
RB |
denotes |
Additionally |
T16160 |
65098-65106 |
VBN |
denotes |
assessed |
T16161 |
65075-65077 |
, |
denotes |
, |
T16162 |
65077-65085 |
NN |
denotes |
learning |
T16163 |
65086-65092 |
NNS |
denotes |
curves |
T16164 |
65093-65097 |
VBD |
denotes |
were |
T16165 |
65107-65109 |
IN |
denotes |
by |
T16166 |
65110-65118 |
RB |
denotes |
linearly |
T16167 |
65119-65126 |
VBG |
denotes |
fitting |
T16168 |
65127-65129 |
IN |
denotes |
of |
T16169 |
65130-65135 |
NN |
denotes |
trend |
T16170 |
65136-65141 |
NNS |
denotes |
lines |
T16171 |
65142-65144 |
IN |
denotes |
to |
T16172 |
65145-65148 |
DT |
denotes |
the |
T16173 |
65149-65153 |
NNS |
denotes |
data |
T16174 |
65154-65158 |
IN |
denotes |
with |
T16175 |
65159-65164 |
VBN |
denotes |
fixed |
T16176 |
65165-65172 |
NNS |
denotes |
offsets |
T16177 |
65172-65174 |
, |
denotes |
, |
T16178 |
65174-65181 |
VBG |
denotes |
leaving |
T16179 |
65182-65185 |
DT |
denotes |
the |
T16180 |
65186-65191 |
NN |
denotes |
slope |
T16181 |
65192-65194 |
IN |
denotes |
as |
T16182 |
65195-65198 |
DT |
denotes |
the |
T16183 |
65204-65212 |
NN |
denotes |
variable |
T16184 |
65199-65203 |
JJ |
denotes |
only |
T16185 |
65212-65213 |
. |
denotes |
. |
T16186 |
65213-65259 |
sentence |
denotes |
In general, binning was 100 trials per block. |
T16187 |
65214-65216 |
IN |
denotes |
In |
T16188 |
65234-65237 |
VBD |
denotes |
was |
T16189 |
65217-65224 |
JJ |
denotes |
general |
T16190 |
65224-65226 |
, |
denotes |
, |
T16191 |
65226-65233 |
VBG |
denotes |
binning |
T16192 |
65238-65241 |
CD |
denotes |
100 |
T16193 |
65242-65248 |
NNS |
denotes |
trials |
T16194 |
65249-65252 |
IN |
denotes |
per |
T16195 |
65253-65258 |
NN |
denotes |
block |
T16196 |
65258-65259 |
. |
denotes |
. |
T16197 |
65259-65390 |
sentence |
denotes |
To allow for the investigation of group/block interactions, the repeated measure ANOVA binning was reduced to 20 trials per block. |
T16198 |
65260-65262 |
TO |
denotes |
To |
T16199 |
65263-65268 |
VB |
denotes |
allow |
T16200 |
65359-65366 |
VBN |
denotes |
reduced |
T16201 |
65269-65272 |
IN |
denotes |
for |
T16202 |
65273-65276 |
DT |
denotes |
the |
T16203 |
65277-65290 |
NN |
denotes |
investigation |
T16204 |
65291-65293 |
IN |
denotes |
of |
T16205 |
65294-65299 |
NN |
denotes |
group |
T16206 |
65300-65305 |
NN |
denotes |
block |
T16207 |
65299-65300 |
HYPH |
denotes |
/ |
T16208 |
65306-65318 |
NNS |
denotes |
interactions |
T16209 |
65318-65320 |
, |
denotes |
, |
T16210 |
65320-65323 |
DT |
denotes |
the |
T16211 |
65347-65354 |
NN |
denotes |
binning |
T16212 |
65324-65332 |
VBN |
denotes |
repeated |
T16213 |
65333-65340 |
NN |
denotes |
measure |
T16214 |
65341-65346 |
NN |
denotes |
ANOVA |
T16215 |
65355-65358 |
VBD |
denotes |
was |
T16216 |
65367-65369 |
IN |
denotes |
to |
T16217 |
65370-65372 |
CD |
denotes |
20 |
T16218 |
65373-65379 |
NNS |
denotes |
trials |
T16219 |
65380-65383 |
IN |
denotes |
per |
T16220 |
65384-65389 |
NN |
denotes |
block |
T16221 |
65389-65390 |
. |
denotes |
. |
T16222 |
65390-65541 |
sentence |
denotes |
To compare memory performance in the GluR-BRescue (n = 8) and GluR-BΔFB (n = 22) mice, due to the high variability, a bootstrap approach was employed. |
T16223 |
65391-65393 |
TO |
denotes |
To |
T16224 |
65394-65401 |
VB |
denotes |
compare |
T16225 |
65532-65540 |
VBN |
denotes |
employed |
T16226 |
65402-65408 |
NN |
denotes |
memory |
T16227 |
65409-65420 |
NN |
denotes |
performance |
T16228 |
65421-65423 |
IN |
denotes |
in |
T16229 |
65424-65427 |
DT |
denotes |
the |
T16230 |
65472-65476 |
NNS |
denotes |
mice |
T16231 |
65428-65432 |
NN |
denotes |
GluR |
T16232 |
65433-65440 |
NN |
denotes |
BRescue |
T16233 |
65432-65433 |
HYPH |
denotes |
- |
T16234 |
65441-65442 |
-LRB- |
denotes |
( |
T16235 |
65446-65447 |
CD |
denotes |
8 |
T16236 |
65442-65443 |
NN |
denotes |
n |
T16237 |
65444-65445 |
SYM |
denotes |
= |
T16238 |
65447-65448 |
-RRB- |
denotes |
) |
T16239 |
65449-65452 |
CC |
denotes |
and |
T16240 |
65453-65457 |
NN |
denotes |
GluR |
T16241 |
65458-65462 |
NN |
denotes |
BΔFB |
T16242 |
65457-65458 |
HYPH |
denotes |
- |
T16243 |
65463-65464 |
-LRB- |
denotes |
( |
T16244 |
65468-65470 |
CD |
denotes |
22 |
T16245 |
65464-65465 |
NN |
denotes |
n |
T16246 |
65466-65467 |
SYM |
denotes |
= |
T16247 |
65470-65471 |
-RRB- |
denotes |
) |
T16248 |
65476-65478 |
, |
denotes |
, |
T16249 |
65478-65481 |
IN |
denotes |
due |
T16250 |
65482-65484 |
IN |
denotes |
to |
T16251 |
65485-65488 |
DT |
denotes |
the |
T16252 |
65494-65505 |
NN |
denotes |
variability |
T16253 |
65489-65493 |
JJ |
denotes |
high |
T16254 |
65505-65507 |
, |
denotes |
, |
T16255 |
65507-65508 |
DT |
denotes |
a |
T16256 |
65519-65527 |
NN |
denotes |
approach |
T16257 |
65509-65518 |
NN |
denotes |
bootstrap |
T16258 |
65528-65531 |
VBD |
denotes |
was |
T16259 |
65540-65541 |
. |
denotes |
. |
T16260 |
65541-65661 |
sentence |
denotes |
Subpopulations of eight animals were selected from the population of 22 GluR-BΔFB mice, and mean memory was determined. |
T16261 |
65542-65556 |
NNS |
denotes |
Subpopulations |
T16262 |
65579-65587 |
VBN |
denotes |
selected |
T16263 |
65557-65559 |
IN |
denotes |
of |
T16264 |
65560-65565 |
CD |
denotes |
eight |
T16265 |
65566-65573 |
NNS |
denotes |
animals |
T16266 |
65574-65578 |
VBD |
denotes |
were |
T16267 |
65588-65592 |
IN |
denotes |
from |
T16268 |
65593-65596 |
DT |
denotes |
the |
T16269 |
65597-65607 |
NN |
denotes |
population |
T16270 |
65608-65610 |
IN |
denotes |
of |
T16271 |
65611-65613 |
CD |
denotes |
22 |
T16272 |
65624-65628 |
NNS |
denotes |
mice |
T16273 |
65614-65618 |
NN |
denotes |
GluR |
T16274 |
65619-65623 |
NN |
denotes |
BΔFB |
T16275 |
65618-65619 |
HYPH |
denotes |
- |
T16276 |
65628-65630 |
, |
denotes |
, |
T16277 |
65630-65633 |
CC |
denotes |
and |
T16278 |
65634-65638 |
NN |
denotes |
mean |
T16279 |
65639-65645 |
NN |
denotes |
memory |
T16280 |
65650-65660 |
VBN |
denotes |
determined |
T16281 |
65646-65649 |
VBD |
denotes |
was |
T16282 |
65660-65661 |
. |
denotes |
. |
T16283 |
65661-65814 |
sentence |
denotes |
In only 343 out of 20,000 subpopulations, mean memory exceeded the mean GluR-BRescue memory of 74.99%, resulting in a p value of p = 343/20,000 = 0.017. |
T16284 |
65662-65664 |
IN |
denotes |
In |
T16285 |
65716-65724 |
VBD |
denotes |
exceeded |
T16286 |
65665-65669 |
JJ |
denotes |
only |
T16287 |
65681-65687 |
CD |
denotes |
20,000 |
T16288 |
65670-65673 |
CD |
denotes |
343 |
T16289 |
65674-65677 |
IN |
denotes |
out |
T16290 |
65678-65680 |
IN |
denotes |
of |
T16291 |
65688-65702 |
NNS |
denotes |
subpopulations |
T16292 |
65702-65704 |
, |
denotes |
, |
T16293 |
65704-65708 |
NN |
denotes |
mean |
T16294 |
65709-65715 |
NN |
denotes |
memory |
T16295 |
65725-65728 |
DT |
denotes |
the |
T16296 |
65747-65753 |
NN |
denotes |
memory |
T16297 |
65729-65733 |
NN |
denotes |
mean |
T16298 |
65734-65738 |
NN |
denotes |
GluR |
T16299 |
65739-65746 |
NN |
denotes |
BRescue |
T16300 |
65738-65739 |
HYPH |
denotes |
- |
T16301 |
65754-65756 |
IN |
denotes |
of |
T16302 |
65757-65762 |
CD |
denotes |
74.99 |
T16303 |
65762-65763 |
NN |
denotes |
% |
T16304 |
65763-65765 |
, |
denotes |
, |
T16305 |
65765-65774 |
VBG |
denotes |
resulting |
T16306 |
65775-65777 |
IN |
denotes |
in |
T16307 |
65778-65779 |
DT |
denotes |
a |
T16308 |
65782-65787 |
NN |
denotes |
value |
T16309 |
65780-65781 |
NN |
denotes |
p |
T16310 |
65788-65790 |
IN |
denotes |
of |
T16311 |
65791-65792 |
NN |
denotes |
p |
T16312 |
65799-65805 |
CD |
denotes |
20,000 |
T16313 |
65793-65794 |
SYM |
denotes |
= |
T16314 |
65795-65798 |
CD |
denotes |
343 |
T16315 |
65798-65799 |
HYPH |
denotes |
/ |
T16316 |
65806-65807 |
SYM |
denotes |
= |
T16317 |
65808-65813 |
CD |
denotes |
0.017 |
T16318 |
65813-65814 |
. |
denotes |
. |
T15859 |
63869-63885 |
VBG |
denotes |
counterbalancing |
T3837 |
14499-14507 |
NN |
denotes |
addition |
T3838 |
14507-14509 |
, |
denotes |
, |
T3839 |
14509-14511 |
IN |
denotes |
in |
T3840 |
14512-14520 |
NN |
denotes |
contrast |
T3841 |
14521-14523 |
IN |
denotes |
to |
T3842 |
14524-14527 |
DT |
denotes |
the |
T3843 |
14544-14553 |
NNS |
denotes |
knockouts |
T3844 |
14528-14536 |
JJ |
denotes |
complete |
T3845 |
14537-14541 |
NN |
denotes |
GluR |
T3846 |
14542-14543 |
NN |
denotes |
B |
T3847 |
14541-14542 |
HYPH |
denotes |
- |
T3848 |
14553-14555 |
, |
denotes |
, |
T3849 |
14555-14559 |
NNS |
denotes |
mice |
T3850 |
14560-14564 |
IN |
denotes |
with |
T3851 |
14565-14574 |
NN |
denotes |
forebrain |
T3852 |
14575-14583 |
JJ |
denotes |
specific |
T3853 |
14574-14575 |
HYPH |
denotes |
- |
T3854 |
14591-14600 |
NN |
denotes |
depletion |
T3855 |
14584-14588 |
NN |
denotes |
GluR |
T3856 |
14589-14590 |
NN |
denotes |
B |
T3857 |
14588-14589 |
HYPH |
denotes |
- |
T3858 |
14610-14616 |
JJ |
denotes |
normal |
T3859 |
14617-14627 |
IN |
denotes |
throughout |
T3860 |
14628-14632 |
NN |
denotes |
life |
T3861 |
14633-14637 |
IN |
denotes |
with |
T3862 |
14638-14640 |
DT |
denotes |
no |
T3863 |
14655-14668 |
NNS |
denotes |
abnormalities |
T3864 |
14641-14654 |
JJ |
denotes |
developmental |
T3865 |
14668-14670 |
, |
denotes |
, |
T3866 |
14670-14672 |
CC |
denotes |
or |
T3867 |
14673-14683 |
NN |
denotes |
difference |
T3868 |
14684-14686 |
IN |
denotes |
in |
T3869 |
14687-14691 |
NN |
denotes |
body |
T3870 |
14692-14696 |
NN |
denotes |
size |
T3871 |
14697-14700 |
CC |
denotes |
and |
T3872 |
14701-14707 |
NN |
denotes |
weight |
T3873 |
14708-14710 |
IN |
denotes |
in |
T3874 |
14711-14720 |
NN |
denotes |
adulthood |
T3875 |
14721-14722 |
-LRB- |
denotes |
( |
T3876 |
14779-14781 |
CD |
denotes |
10 |
T3877 |
14722-14726 |
JJ |
denotes |
wild |
T4698 |
19665-19673 |
VBG |
denotes |
allowing |
T3878 |
14727-14731 |
NN |
denotes |
type |
T3879 |
14726-14727 |
HYPH |
denotes |
- |
T3880 |
14738-14739 |
NN |
denotes |
g |
T3881 |
14731-14733 |
: |
denotes |
: |
T3882 |
14733-14737 |
CD |
denotes |
31.0 |
T3883 |
14740-14741 |
SYM |
denotes |
± |
T3884 |
14742-14745 |
CD |
denotes |
1.2 |
T3885 |
14745-14746 |
: |
denotes |
; |
T3886 |
14747-14751 |
NN |
denotes |
GluR |
T3887 |
14752-14756 |
NN |
denotes |
BΔFB |
T3888 |
14751-14752 |
HYPH |
denotes |
- |
T3889 |
14765-14768 |
CD |
denotes |
0.9 |
T3890 |
14756-14758 |
: |
denotes |
: |
T3891 |
14758-14762 |
CD |
denotes |
28.4 |
T3892 |
14763-14764 |
SYM |
denotes |
± |
T3893 |
14768-14769 |
: |
denotes |
; |
T3894 |
14770-14774 |
DT |
denotes |
each |
T3895 |
14775-14776 |
NN |
denotes |
n |
T3896 |
14777-14778 |
SYM |
denotes |
= |
T3897 |
14781-14782 |
-RRB- |
denotes |
) |
T3898 |
14782-14783 |
. |
denotes |
. |
T3899 |
14783-14963 |
sentence |
denotes |
Exploratory activity in an open field task was slightly increased in GluR-BΔFB mice (3,480 cm ± 180, n = 11), compared with wild-type littermates (2,512 cm ± 96, n = 12, p <0.01). |
T3900 |
14784-14795 |
JJ |
denotes |
Exploratory |
T3901 |
14796-14804 |
NN |
denotes |
activity |
T3902 |
14827-14830 |
VBD |
denotes |
was |
T3903 |
14805-14807 |
IN |
denotes |
in |
T3904 |
14808-14810 |
DT |
denotes |
an |
T3905 |
14822-14826 |
NN |
denotes |
task |
T3906 |
14811-14815 |
JJ |
denotes |
open |
T3907 |
14816-14821 |
NN |
denotes |
field |
T3908 |
14831-14839 |
RB |
denotes |
slightly |
T3909 |
14840-14849 |
VBN |
denotes |
increased |
T3910 |
14850-14852 |
IN |
denotes |
in |
T3911 |
14853-14857 |
NN |
denotes |
GluR |
T3912 |
14858-14862 |
NN |
denotes |
BΔFB |
T3913 |
14857-14858 |
HYPH |
denotes |
- |
T3914 |
14863-14867 |
NNS |
denotes |
mice |
T3915 |
14868-14869 |
-LRB- |
denotes |
( |
T3916 |
14875-14877 |
NN |
denotes |
cm |
T3917 |
14869-14874 |
CD |
denotes |
3,480 |
T3918 |
14878-14879 |
SYM |
denotes |
± |
T3919 |
14880-14883 |
CD |
denotes |
180 |
T3920 |
14883-14885 |
, |
denotes |
, |
T3921 |
14885-14886 |
NN |
denotes |
n |
T3922 |
14889-14891 |
CD |
denotes |
11 |
T3923 |
14887-14888 |
SYM |
denotes |
= |
T3924 |
14891-14892 |
-RRB- |
denotes |
) |
T3925 |
14892-14894 |
, |
denotes |
, |
T3926 |
14894-14902 |
VBN |
denotes |
compared |
T3927 |
14903-14907 |
IN |
denotes |
with |
T3928 |
14908-14912 |
JJ |
denotes |
wild |
T3929 |
14913-14917 |
NN |
denotes |
type |
T3930 |
14912-14913 |
HYPH |
denotes |
- |
T3931 |
14918-14929 |
NNS |
denotes |
littermates |
T3932 |
14930-14931 |
-LRB- |
denotes |
( |
T3933 |
14937-14939 |
NN |
denotes |
cm |
T3934 |
14931-14936 |
CD |
denotes |
2,512 |
T3935 |
14940-14941 |
SYM |
denotes |
± |
T3936 |
14942-14944 |
CD |
denotes |
96 |
T3937 |
14944-14946 |
, |
denotes |
, |
T3938 |
14946-14947 |
NN |
denotes |
n |
T3939 |
14950-14952 |
CD |
denotes |
12 |
T3940 |
14948-14949 |
SYM |
denotes |
= |
T3941 |
14957-14961 |
CD |
denotes |
0.01 |
T3942 |
14952-14954 |
, |
denotes |
, |
T3943 |
14956-14957 |
SYM |
denotes |
< |
T3944 |
14961-14962 |
-RRB- |
denotes |
) |
T3945 |
14962-14963 |
. |
denotes |
. |
T3946 |
14963-15130 |
sentence |
denotes |
Motor coordination measured in an accelerating rotarod was somewhat impaired in the mutant mice (wild-type: 156 s ± 37, n = 6; GluR-BΔFB: 37 s ± 10, n = 6; p < 0.05). |
T3947 |
14964-14969 |
NN |
denotes |
Motor |
T3948 |
14970-14982 |
NN |
denotes |
coordination |
T3949 |
15032-15040 |
VBN |
denotes |
impaired |
T3950 |
14983-14991 |
VBN |
denotes |
measured |
T3951 |
14992-14994 |
IN |
denotes |
in |
T3952 |
14995-14997 |
DT |
denotes |
an |
T3953 |
15011-15018 |
NN |
denotes |
rotarod |
T3954 |
14998-15010 |
VBG |
denotes |
accelerating |
T3955 |
15019-15022 |
VBD |
denotes |
was |
T3956 |
15023-15031 |
RB |
denotes |
somewhat |
T3957 |
15041-15043 |
IN |
denotes |
in |
T3958 |
15044-15047 |
DT |
denotes |
the |
T3959 |
15055-15059 |
NNS |
denotes |
mice |
T3960 |
15048-15054 |
NN |
denotes |
mutant |
T3961 |
15060-15061 |
-LRB- |
denotes |
( |
T3962 |
15124-15128 |
CD |
denotes |
0.05 |
T3963 |
15061-15065 |
JJ |
denotes |
wild |
T3964 |
15066-15070 |
NN |
denotes |
type |
T3965 |
15065-15066 |
HYPH |
denotes |
- |
T3966 |
15088-15089 |
CD |
denotes |
6 |
T3967 |
15070-15072 |
: |
denotes |
: |
T3968 |
15072-15075 |
CD |
denotes |
156 |
T3969 |
15076-15077 |
NN |
denotes |
s |
T3970 |
15078-15079 |
SYM |
denotes |
± |
T3971 |
15080-15082 |
CD |
denotes |
37 |
T3972 |
15082-15084 |
, |
denotes |
, |
T3973 |
15084-15085 |
NN |
denotes |
n |
T3974 |
15086-15087 |
SYM |
denotes |
= |
T3975 |
15089-15090 |
: |
denotes |
; |
T3976 |
15091-15095 |
NN |
denotes |
GluR |
T3977 |
15096-15100 |
NN |
denotes |
BΔFB |
T3978 |
15095-15096 |
HYPH |
denotes |
- |
T3979 |
15117-15118 |
CD |
denotes |
6 |
T3980 |
15100-15102 |
: |
denotes |
: |
T3981 |
15102-15104 |
CD |
denotes |
37 |
T3982 |
15105-15106 |
NN |
denotes |
s |
T3983 |
15107-15108 |
SYM |
denotes |
± |
T3984 |
15109-15111 |
CD |
denotes |
10 |
T3985 |
15111-15113 |
, |
denotes |
, |
T3986 |
15113-15114 |
NN |
denotes |
n |
T3987 |
15115-15116 |
SYM |
denotes |
= |
T3988 |
15118-15119 |
: |
denotes |
; |
T3989 |
15120-15121 |
NN |
denotes |
p |
T3990 |
15122-15123 |
SYM |
denotes |
< |
T3991 |
15128-15129 |
-RRB- |
denotes |
) |
T3992 |
15129-15130 |
. |
denotes |
. |
T3993 |
15130-15457 |
sentence |
denotes |
Tests in the dark/light box revealed increased anxiety of GluR-BΔFB mice (latency of first exit: wild-type [17 s ± 3], GluR-BΔFB [97 s ± 42], p = 0.047; compartment changes: wild-type [17 s ± 3], GluR-BΔFB [7 ± 2], p < 0.05; time spent in lit compartment: wild-type [103 s ± 10], GluR-BΔFB [59 s ± 19], p = 0.051; each n = 6). |
T3994 |
15131-15136 |
NNS |
denotes |
Tests |
T4014 |
15213-15215 |
IN |
denotes |
of |
T3995 |
15159-15167 |
VBD |
denotes |
revealed |
T4042 |
15350-15354 |
CD |
denotes |
0.05 |
T3996 |
15137-15139 |
IN |
denotes |
in |
T3997 |
15140-15143 |
DT |
denotes |
the |
T3998 |
15155-15158 |
NN |
denotes |
box |
T3999 |
15144-15148 |
NN |
denotes |
dark |
T4000 |
15149-15154 |
NN |
denotes |
light |
T4001 |
15148-15149 |
HYPH |
denotes |
/ |
T4002 |
15250-15254 |
NN |
denotes |
GluR |
T4003 |
15168-15177 |
VBN |
denotes |
increased |
T4004 |
15178-15185 |
NN |
denotes |
anxiety |
T4005 |
15186-15188 |
IN |
denotes |
of |
T4006 |
15189-15193 |
NN |
denotes |
GluR |
T4007 |
15194-15198 |
NN |
denotes |
BΔFB |
T4008 |
15193-15194 |
HYPH |
denotes |
- |
T4009 |
15199-15203 |
NNS |
denotes |
mice |
T4010 |
15204-15205 |
-LRB- |
denotes |
( |
T4011 |
15454-15455 |
CD |
denotes |
6 |
T4012 |
15205-15212 |
NN |
denotes |
latency |
T4013 |
15277-15282 |
CD |
denotes |
0.047 |
T4015 |
15216-15221 |
JJ |
denotes |
first |
T4016 |
15222-15226 |
NN |
denotes |
exit |
T4017 |
15226-15228 |
: |
denotes |
: |
T4018 |
15228-15232 |
JJ |
denotes |
wild |
T4019 |
15233-15237 |
NN |
denotes |
type |
T4020 |
15232-15233 |
HYPH |
denotes |
- |
T4021 |
15242-15243 |
NN |
denotes |
s |
T4022 |
15238-15239 |
-LRB- |
denotes |
[ |
T4023 |
15239-15241 |
CD |
denotes |
17 |
T4024 |
15244-15245 |
SYM |
denotes |
± |
T4025 |
15246-15247 |
CD |
denotes |
3 |
T4026 |
15247-15248 |
-RRB- |
denotes |
] |
T4027 |
15248-15250 |
, |
denotes |
, |
T4028 |
15255-15259 |
NN |
denotes |
BΔFB |
T4029 |
15254-15255 |
HYPH |
denotes |
- |
T4030 |
15264-15265 |
NN |
denotes |
s |
T4031 |
15260-15261 |
-LRB- |
denotes |
[ |
T4032 |
15261-15263 |
CD |
denotes |
97 |
T4033 |
15266-15267 |
SYM |
denotes |
± |
T4034 |
15268-15270 |
CD |
denotes |
42 |
T4035 |
15270-15271 |
-RRB- |
denotes |
] |
T4036 |
15271-15273 |
, |
denotes |
, |
T4037 |
15273-15274 |
NN |
denotes |
p |
T4038 |
15275-15276 |
SYM |
denotes |
= |
T4039 |
15282-15283 |
: |
denotes |
; |
T4040 |
15284-15295 |
NN |
denotes |
compartment |
T4041 |
15296-15303 |
NNS |
denotes |
changes |
T4043 |
15303-15305 |
: |
denotes |
: |
T4044 |
15305-15309 |
JJ |
denotes |
wild |
T4045 |
15310-15314 |
NN |
denotes |
type |
T4046 |
15309-15310 |
HYPH |
denotes |
- |
T4047 |
15319-15320 |
NN |
denotes |
s |
T4048 |
15315-15316 |
-LRB- |
denotes |
[ |
T4049 |
15316-15318 |
CD |
denotes |
17 |
T4050 |
15321-15322 |
SYM |
denotes |
± |
T4051 |
15323-15324 |
CD |
denotes |
3 |
T4052 |
15324-15325 |
-RRB- |
denotes |
] |
T4053 |
15325-15327 |
, |
denotes |
, |
T4054 |
15327-15331 |
NN |
denotes |
GluR |
T4055 |
15332-15336 |
NN |
denotes |
BΔFB |
T4056 |
15331-15332 |
HYPH |
denotes |
- |
T4057 |
15342-15343 |
CD |
denotes |
2 |
T4058 |
15337-15338 |
-LRB- |
denotes |
[ |
T4059 |
15354-15355 |
: |
denotes |
; |
T4060 |
15338-15339 |
CD |
denotes |
7 |
T4061 |
15558-15566 |
NN |
denotes |
activity |
T4062 |
15340-15341 |
SYM |
denotes |
± |
T4063 |
17075-17076 |
NN |
denotes |
B |
T4064 |
17548-17549 |
'' |
denotes |
” |
T4065 |
15343-15344 |
-RRB- |
denotes |
] |
T4066 |
15344-15346 |
, |
denotes |
, |
T4067 |
15346-15347 |
NN |
denotes |
p |
T4068 |
15348-15349 |
SYM |
denotes |
< |
T4069 |
15356-15360 |
NN |
denotes |
time |
T4070 |
15438-15443 |
CD |
denotes |
0.051 |
T4071 |
15361-15366 |
VBN |
denotes |
spent |
T4072 |
15367-15369 |
IN |
denotes |
in |
T4073 |
15370-15373 |
VBN |
denotes |
lit |
T4074 |
15374-15385 |
NN |
denotes |
compartment |
T4075 |
15385-15387 |
: |
denotes |
: |
T4076 |
15387-15391 |
JJ |
denotes |
wild |
T4077 |
15392-15396 |
NN |
denotes |
type |
T4078 |
15391-15392 |
HYPH |
denotes |
- |
T4079 |
15402-15403 |
NN |
denotes |
s |
T4080 |
15397-15398 |
-LRB- |
denotes |
[ |
T4081 |
15398-15401 |
CD |
denotes |
103 |
T4082 |
15404-15405 |
SYM |
denotes |
± |
T4083 |
15406-15408 |
CD |
denotes |
10 |
T4084 |
15408-15409 |
-RRB- |
denotes |
] |
T4085 |
15409-15411 |
, |
denotes |
, |
T4086 |
15411-15415 |
NN |
denotes |
GluR |
T4087 |
15416-15420 |
NN |
denotes |
BΔFB |
T4088 |
15415-15416 |
HYPH |
denotes |
- |
T4089 |
15425-15426 |
NN |
denotes |
s |
T4090 |
15421-15422 |
-LRB- |
denotes |
[ |
T4091 |
15422-15424 |
CD |
denotes |
59 |
T4092 |
15427-15428 |
SYM |
denotes |
± |
T4093 |
15429-15431 |
CD |
denotes |
19 |
T4094 |
15431-15432 |
-RRB- |
denotes |
] |
T4095 |
15432-15434 |
, |
denotes |
, |
T4096 |
15434-15435 |
NN |
denotes |
p |
T4097 |
15436-15437 |
SYM |
denotes |
= |
T4098 |
15443-15444 |
: |
denotes |
; |
T4099 |
15445-15449 |
DT |
denotes |
each |
T4100 |
15450-15451 |
NN |
denotes |
n |
T4101 |
15452-15453 |
SYM |
denotes |
= |
T4102 |
15455-15456 |
-RRB- |
denotes |
) |
T4103 |
15456-15457 |
. |
denotes |
. |
T4104 |
15457-15682 |
sentence |
denotes |
Hence, unlike the complete GluR-B knockouts, GluR-BΔFB mice show only very minor changes in general activity and no sign of any major developmental disturbance, thus allowing detailed, quantitative behavioral investigations. |
T4105 |
15458-15463 |
RB |
denotes |
Hence |
T4106 |
15518-15522 |
VBP |
denotes |
show |
T4107 |
15463-15465 |
, |
denotes |
, |
T4108 |
15465-15471 |
IN |
denotes |
unlike |
T4109 |
15472-15475 |
DT |
denotes |
the |
T4110 |
15492-15501 |
NNS |
denotes |
knockouts |
T4111 |
15476-15484 |
JJ |
denotes |
complete |
T4112 |
15485-15489 |
NN |
denotes |
GluR |
T4113 |
15490-15491 |
NN |
denotes |
B |
T4114 |
15489-15490 |
HYPH |
denotes |
- |
T4115 |
15501-15503 |
, |
denotes |
, |
T4116 |
15503-15507 |
NN |
denotes |
GluR |
T4117 |
15508-15512 |
NN |
denotes |
BΔFB |
T4118 |
15507-15508 |
HYPH |
denotes |
- |
T4119 |
15513-15517 |
NNS |
denotes |
mice |
T4120 |
15523-15527 |
RB |
denotes |
only |
T4121 |
15539-15546 |
NNS |
denotes |
changes |
T4122 |
15528-15532 |
RB |
denotes |
very |
T4123 |
15533-15538 |
JJ |
denotes |
minor |
T4124 |
15547-15549 |
IN |
denotes |
in |
T4125 |
15550-15557 |
JJ |
denotes |
general |
T4126 |
15567-15570 |
CC |
denotes |
and |
T4127 |
15571-15573 |
DT |
denotes |
no |
T4128 |
15574-15578 |
NN |
denotes |
sign |
T4129 |
15579-15581 |
IN |
denotes |
of |
T4130 |
15582-15585 |
DT |
denotes |
any |
T4131 |
15606-15617 |
NN |
denotes |
disturbance |
T4132 |
15586-15591 |
JJ |
denotes |
major |
T4133 |
15592-15605 |
JJ |
denotes |
developmental |
T4134 |
15617-15619 |
, |
denotes |
, |
T4135 |
15619-15623 |
RB |
denotes |
thus |
T4136 |
15624-15632 |
VBG |
denotes |
allowing |
T4137 |
15633-15641 |
JJ |
denotes |
detailed |
T4138 |
15667-15681 |
NNS |
denotes |
investigations |
T4139 |
15641-15643 |
, |
denotes |
, |
T4140 |
15643-15655 |
JJ |
denotes |
quantitative |
T4141 |
15656-15666 |
JJ |
denotes |
behavioral |
T4142 |
15681-15682 |
. |
denotes |
. |
T4143 |
15682-17297 |
sentence |
denotes |
Figure 2 Odor Learning and Discrimination Is Enhanced, but Odor Memory Is Reduced in GluR-BΔFB Mice
(A) Schematic diagram depicting Cre-mediated ablation of loxP-flanked exon 11 of the GluR-B alleles.
(B and C) Nine GluR-BΔFB (red) and nine GluRB2lox littermate controls (black) were trained for successive odor discrimination tasks on 1% AA versus 1% EB (400 trials), 0.4% Cin/0.6% Eu versus 0.6% Cin/0.4% Eu (400 trials) and 1% Pel versus 1% Val. GluR-BΔFB mice showed increased learning/discrimination compared with controls, both using the performance as measured by percentage of correct trials ([B]; group effect: F1,16 = 6.55, p < 0.05) or the discrimination index (C), that is the maximal difference of the sampling pattern (see Materials and Methods and Figure 1D–1F; F1,16 = 29.5, p < 10−4).
(D) Sampling difference for the last 100 trials of the mixture discrimination task (indicated with a black arrow in [C]) for all 18 individual mice. Note that the GluR-BΔFB mice show a consistently larger sampling difference.
(E) Olfactory memory performance for nine littermate controls (black) and nine GluR-BΔFB (red) mice. Olfactory memory was tested at the time indicated by the black bar in (C) by interleaving the Pel and Val trials with unrewarded AA and EB trials. AA, amylacetate; Cin, cineol; EB, ethylbutyrate; Eu, eugenol; Pel, pelargonic acid; Val, valeric acid. If the GluR-B/GluR-B(Q) switch-induced alterations in the Ca2+ permeability of the AMPA channels are linked to enhanced odor discrimination and learning, the depletion of the GluR-B subunit should lead to a similar phenotypic readout. |
T4144 |
17063-17065 |
IN |
denotes |
If |
T4145 |
17164-17170 |
VBN |
denotes |
linked |
T4146 |
17066-17069 |
DT |
denotes |
the |
T4147 |
17102-17113 |
NNS |
denotes |
alterations |
T4148 |
17070-17074 |
NN |
denotes |
GluR |
T4149 |
17074-17075 |
HYPH |
denotes |
- |
T4214 |
17405-17407 |
DT |
denotes |
no |
T4150 |
17076-17077 |
HYPH |
denotes |
/ |
T4151 |
17077-17081 |
NN |
denotes |
GluR |
T4226 |
17465-17469 |
RB |
denotes |
even |
T4152 |
17082-17083 |
NN |
denotes |
B |
T4153 |
17081-17082 |
HYPH |
denotes |
- |
T4154 |
17083-17084 |
-LRB- |
denotes |
( |
T4155 |
17084-17085 |
NN |
denotes |
Q |
T4156 |
17085-17086 |
-RRB- |
denotes |
) |
T4157 |
17087-17093 |
NN |
denotes |
switch |
T4158 |
17094-17101 |
VBN |
denotes |
induced |
T4159 |
17093-17094 |
HYPH |
denotes |
- |
T4160 |
17114-17116 |
IN |
denotes |
in |
T4161 |
17117-17120 |
DT |
denotes |
the |
T4162 |
17126-17138 |
NN |
denotes |
permeability |
T4163 |
17121-17124 |
NN |
denotes |
Ca2 |
T4164 |
17124-17125 |
SYM |
denotes |
+ |
T4165 |
17139-17141 |
IN |
denotes |
of |
T4166 |
17142-17145 |
DT |
denotes |
the |
T4167 |
17151-17159 |
NNS |
denotes |
channels |
T4168 |
17146-17150 |
NN |
denotes |
AMPA |
T4169 |
17160-17163 |
VBP |
denotes |
are |
T4170 |
17260-17264 |
VB |
denotes |
lead |
T4171 |
17171-17173 |
IN |
denotes |
to |
T4172 |
17174-17182 |
VBN |
denotes |
enhanced |
T4173 |
17188-17202 |
NN |
denotes |
discrimination |
T4174 |
17183-17187 |
NN |
denotes |
odor |
T4175 |
17203-17206 |
CC |
denotes |
and |
T4176 |
17207-17215 |
NN |
denotes |
learning |
T4177 |
17215-17217 |
, |
denotes |
, |
T4178 |
17217-17220 |
DT |
denotes |
the |
T4179 |
17221-17230 |
NN |
denotes |
depletion |
T4180 |
17231-17233 |
IN |
denotes |
of |
T4181 |
17234-17237 |
DT |
denotes |
the |
T4182 |
17245-17252 |
NN |
denotes |
subunit |
T4183 |
17238-17242 |
NN |
denotes |
GluR |
T4184 |
17243-17244 |
NN |
denotes |
B |
T4185 |
17242-17243 |
HYPH |
denotes |
- |
T4186 |
17253-17259 |
MD |
denotes |
should |
T4187 |
17265-17267 |
IN |
denotes |
to |
T4188 |
17268-17269 |
DT |
denotes |
a |
T4189 |
17289-17296 |
NN |
denotes |
readout |
T4190 |
17270-17277 |
JJ |
denotes |
similar |
T4191 |
17278-17288 |
JJ |
denotes |
phenotypic |
T4192 |
17296-17297 |
. |
denotes |
. |
T4193 |
17297-17455 |
sentence |
denotes |
We therefore trained nine GluR-BΔFB mice and nine littermate controls in the same automated associative go/no-go olfactory conditioning task described above. |
T4194 |
17298-17300 |
PRP |
denotes |
We |
T4195 |
17311-17318 |
VBD |
denotes |
trained |
T4196 |
17301-17310 |
RB |
denotes |
therefore |
T4197 |
17319-17323 |
CD |
denotes |
nine |
T4198 |
17334-17338 |
NNS |
denotes |
mice |
T4199 |
17324-17328 |
NN |
denotes |
GluR |
T4200 |
17329-17333 |
NN |
denotes |
BΔFB |
T4201 |
17328-17329 |
HYPH |
denotes |
- |
T4202 |
17339-17342 |
CC |
denotes |
and |
T4203 |
17343-17347 |
CD |
denotes |
nine |
T4204 |
17359-17367 |
NNS |
denotes |
controls |
T4205 |
17348-17358 |
NN |
denotes |
littermate |
T4206 |
17368-17370 |
IN |
denotes |
in |
T4207 |
17371-17374 |
DT |
denotes |
the |
T4208 |
17434-17438 |
NN |
denotes |
task |
T4209 |
17375-17379 |
JJ |
denotes |
same |
T4210 |
17380-17389 |
VBN |
denotes |
automated |
T4211 |
17390-17401 |
JJ |
denotes |
associative |
T4212 |
17402-17404 |
NN |
denotes |
go |
T4213 |
17404-17405 |
HYPH |
denotes |
/ |
T4215 |
17408-17410 |
NN |
denotes |
go |
T4216 |
17407-17408 |
HYPH |
denotes |
- |
T4217 |
17411-17420 |
JJ |
denotes |
olfactory |
T4218 |
17421-17433 |
NN |
denotes |
conditioning |
T4219 |
17439-17448 |
VBN |
denotes |
described |
T4220 |
17449-17454 |
RB |
denotes |
above |
T4221 |
17454-17455 |
. |
denotes |
. |
T4222 |
17455-17606 |
sentence |
denotes |
To cover even small phenotypic changes in olfaction, we tested different odor pairs, “simple” monomolecular odors and “difficult” binary mixtures [3]. |
T4223 |
17456-17458 |
TO |
denotes |
To |
T4224 |
17459-17464 |
VB |
denotes |
cover |
T4225 |
17512-17518 |
VBD |
denotes |
tested |
T4227 |
17487-17494 |
NNS |
denotes |
changes |
T4228 |
17470-17475 |
JJ |
denotes |
small |
T4229 |
17476-17486 |
JJ |
denotes |
phenotypic |
T4230 |
17495-17497 |
IN |
denotes |
in |
T4231 |
17498-17507 |
NN |
denotes |
olfaction |
T4232 |
17507-17509 |
, |
denotes |
, |
T4233 |
17509-17511 |
PRP |
denotes |
we |
T4234 |
17519-17528 |
JJ |
denotes |
different |
T4235 |
17534-17539 |
NNS |
denotes |
pairs |
T4236 |
17529-17533 |
NN |
denotes |
odor |
T4237 |
17539-17541 |
, |
denotes |
, |
T4238 |
17541-17542 |
`` |
denotes |
“ |
T4239 |
17564-17569 |
NNS |
denotes |
odors |
T4240 |
17542-17548 |
JJ |
denotes |
simple |
T4241 |
17550-17563 |
JJ |
denotes |
monomolecular |
T4242 |
17570-17573 |
CC |
denotes |
and |
T4243 |
17574-17575 |
`` |
denotes |
“ |
T4244 |
17593-17601 |
NNS |
denotes |
mixtures |
T4245 |
17575-17584 |
JJ |
denotes |
difficult |
T4246 |
17584-17585 |
'' |
denotes |
” |
T4247 |
17586-17592 |
JJ |
denotes |
binary |
T4248 |
17602-17603 |
-LRB- |
denotes |
[ |
T4249 |
17603-17604 |
CD |
denotes |
3 |
T4250 |
17604-17605 |
-RRB- |
denotes |
] |
T4251 |
17605-17606 |
. |
denotes |
. |
T4252 |
17606-17991 |
sentence |
denotes |
After habituation, GluR-BΔFB and control mice were trained to discriminate between the “simple” monomolecular odors amylacetate and ethylbutyrate, and subsequently additionally on a “difficult” discrimination task consisting of similar binary mixtures of cineol and eugenol; and finally again on a “simple” discrimination task with the monomolecular odors pelargonic and valeric acid. |
T4253 |
17607-17612 |
IN |
denotes |
After |
T4254 |
17658-17665 |
VBN |
denotes |
trained |
T4255 |
17613-17624 |
NN |
denotes |
habituation |
T4256 |
17624-17626 |
, |
denotes |
, |
T4257 |
17626-17630 |
NN |
denotes |
GluR |
T4258 |
17631-17635 |
NN |
denotes |
BΔFB |
T4259 |
17630-17631 |
HYPH |
denotes |
- |
T4260 |
17648-17652 |
NNS |
denotes |
mice |
T4261 |
17636-17639 |
CC |
denotes |
and |
T4262 |
17640-17647 |
NN |
denotes |
control |
T4263 |
17653-17657 |
VBD |
denotes |
were |
T4264 |
17666-17668 |
TO |
denotes |
to |
T4265 |
17669-17681 |
VB |
denotes |
discriminate |
T4266 |
17682-17689 |
IN |
denotes |
between |
T4267 |
17690-17693 |
DT |
denotes |
the |
T4268 |
17717-17722 |
NNS |
denotes |
odors |
T4269 |
17694-17695 |
`` |
denotes |
“ |
T4270 |
17695-17701 |
JJ |
denotes |
simple |
T4271 |
17701-17702 |
'' |
denotes |
” |
T4272 |
17703-17716 |
JJ |
denotes |
monomolecular |
T4273 |
17723-17734 |
NN |
denotes |
amylacetate |
T4274 |
17735-17738 |
CC |
denotes |
and |
T4275 |
17739-17752 |
NN |
denotes |
ethylbutyrate |
T4276 |
17752-17754 |
, |
denotes |
, |
T4277 |
17754-17757 |
CC |
denotes |
and |
T4278 |
17758-17770 |
RB |
denotes |
subsequently |
T4279 |
17784-17786 |
IN |
denotes |
on |
T4280 |
17771-17783 |
RB |
denotes |
additionally |
T4281 |
17787-17788 |
DT |
denotes |
a |
T4282 |
17816-17820 |
NN |
denotes |
task |
T4283 |
17789-17790 |
`` |
denotes |
“ |
T4284 |
17790-17799 |
JJ |
denotes |
difficult |
T4285 |
17799-17800 |
'' |
denotes |
” |
T4286 |
17801-17815 |
NN |
denotes |
discrimination |
T4287 |
17821-17831 |
VBG |
denotes |
consisting |
T4288 |
17832-17834 |
IN |
denotes |
of |
T4289 |
17835-17842 |
JJ |
denotes |
similar |
T4290 |
17850-17858 |
NNS |
denotes |
mixtures |
T4291 |
17843-17849 |
JJ |
denotes |
binary |
T4292 |
17859-17861 |
IN |
denotes |
of |
T4293 |
17862-17868 |
NN |
denotes |
cineol |
T4294 |
17869-17872 |
CC |
denotes |
and |
T4295 |
17873-17880 |
NN |
denotes |
eugenol |
T4296 |
17880-17881 |
: |
denotes |
; |
T4297 |
17882-17885 |
CC |
denotes |
and |
T4298 |
17886-17893 |
RB |
denotes |
finally |
T4299 |
17900-17902 |
IN |
denotes |
on |
T4300 |
17894-17899 |
RB |
denotes |
again |
T4301 |
17903-17904 |
DT |
denotes |
a |
T4302 |
17929-17933 |
NN |
denotes |
task |
T4303 |
17905-17906 |
`` |
denotes |
“ |
T4304 |
17906-17912 |
JJ |
denotes |
simple |
T4305 |
17912-17913 |
'' |
denotes |
” |
T4306 |
17914-17928 |
NN |
denotes |
discrimination |
T4307 |
17934-17938 |
IN |
denotes |
with |
T4308 |
17939-17942 |
DT |
denotes |
the |
T4309 |
17957-17962 |
NNS |
denotes |
odors |
T4310 |
17943-17956 |
JJ |
denotes |
monomolecular |
T4311 |
17963-17973 |
JJ |
denotes |
pelargonic |
T4312 |
17986-17990 |
NN |
denotes |
acid |
T4313 |
17974-17977 |
CC |
denotes |
and |
T4314 |
17978-17985 |
JJ |
denotes |
valeric |
T4315 |
17990-17991 |
. |
denotes |
. |
T4316 |
17991-18157 |
sentence |
denotes |
Similar to GluR-BΔECS:FB, GluR-BΔFB mice also showed enhanced learning and discrimination compared with controls (Figure 2B; group effect: F(1,16) = 6.55; p < 0.05). |
T4317 |
17992-17999 |
JJ |
denotes |
Similar |
T4318 |
18038-18044 |
VBD |
denotes |
showed |
T4319 |
18000-18002 |
IN |
denotes |
to |
T4320 |
18003-18007 |
NN |
denotes |
GluR |
T4321 |
18008-18013 |
NN |
denotes |
BΔECS |
T4322 |
18007-18008 |
HYPH |
denotes |
- |
T4323 |
18013-18014 |
: |
denotes |
: |
T4324 |
18014-18016 |
NN |
denotes |
FB |
T4325 |
18016-18018 |
, |
denotes |
, |
T4326 |
18018-18022 |
NN |
denotes |
GluR |
T4327 |
18023-18027 |
NN |
denotes |
BΔFB |
T4328 |
18022-18023 |
HYPH |
denotes |
- |
T4329 |
18028-18032 |
NNS |
denotes |
mice |
T4330 |
18033-18037 |
RB |
denotes |
also |
T4331 |
18045-18053 |
VBN |
denotes |
enhanced |
T4332 |
18054-18062 |
NN |
denotes |
learning |
T4333 |
18063-18066 |
CC |
denotes |
and |
T4334 |
18067-18081 |
NN |
denotes |
discrimination |
T4335 |
18082-18090 |
VBN |
denotes |
compared |
T4336 |
18091-18095 |
IN |
denotes |
with |
T4337 |
18096-18104 |
NNS |
denotes |
controls |
T4338 |
18105-18106 |
-LRB- |
denotes |
( |
T4339 |
18113-18115 |
NN |
denotes |
2B |
T4340 |
18106-18112 |
NN |
denotes |
Figure |
T4341 |
18115-18116 |
: |
denotes |
; |
T4342 |
18117-18122 |
NN |
denotes |
group |
T4343 |
18123-18129 |
NN |
denotes |
effect |
T4344 |
18151-18155 |
CD |
denotes |
0.05 |
T4345 |
18129-18131 |
: |
denotes |
: |
T4346 |
18131-18132 |
NN |
denotes |
F |
T4347 |
18141-18145 |
CD |
denotes |
6.55 |
T4348 |
18132-18133 |
-LRB- |
denotes |
( |
T4349 |
18133-18134 |
CD |
denotes |
1 |
T4350 |
18134-18135 |
, |
denotes |
, |
T4351 |
18135-18137 |
CD |
denotes |
16 |
T4352 |
18137-18138 |
-RRB- |
denotes |
) |
T4353 |
18139-18140 |
SYM |
denotes |
= |
T4354 |
18145-18146 |
: |
denotes |
; |
T4355 |
18147-18148 |
NN |
denotes |
p |
T4356 |
18149-18150 |
SYM |
denotes |
< |
T4357 |
18155-18156 |
-RRB- |
denotes |
) |
T4358 |
18156-18157 |
. |
denotes |
. |
T4359 |
18157-18393 |
sentence |
denotes |
Increased discrimination performance is expected to show more pronounced effects for closely related odors because of the more challenging “difficult” discrimination task that is closer to the psychophysical limits of the system [3,4]. |
T4360 |
18158-18167 |
VBN |
denotes |
Increased |
T4361 |
18183-18194 |
NN |
denotes |
performance |
T4362 |
18168-18182 |
NN |
denotes |
discrimination |
T4363 |
18198-18206 |
VBN |
denotes |
expected |
T4364 |
18195-18197 |
VBZ |
denotes |
is |
T4365 |
18207-18209 |
TO |
denotes |
to |
T4366 |
18210-18214 |
VB |
denotes |
show |
T4367 |
18215-18219 |
RBR |
denotes |
more |
T4368 |
18220-18230 |
JJ |
denotes |
pronounced |
T4369 |
18231-18238 |
NNS |
denotes |
effects |
T4370 |
18239-18242 |
IN |
denotes |
for |
T4371 |
18243-18250 |
RB |
denotes |
closely |
T4372 |
18251-18258 |
JJ |
denotes |
related |
T4373 |
18259-18264 |
NNS |
denotes |
odors |
T4374 |
18265-18272 |
IN |
denotes |
because |
T4375 |
18273-18275 |
IN |
denotes |
of |
T4376 |
18276-18279 |
DT |
denotes |
the |
T4377 |
18324-18328 |
NN |
denotes |
task |
T4378 |
18280-18284 |
RBR |
denotes |
more |
T4379 |
18285-18296 |
JJ |
denotes |
challenging |
T4380 |
18297-18298 |
`` |
denotes |
“ |
T4381 |
18298-18307 |
JJ |
denotes |
difficult |
T4382 |
18307-18308 |
'' |
denotes |
” |
T4383 |
18309-18323 |
NN |
denotes |
discrimination |
T4384 |
18329-18333 |
WDT |
denotes |
that |
T4385 |
18334-18336 |
VBZ |
denotes |
is |
T4386 |
18337-18343 |
JJR |
denotes |
closer |
T4387 |
18344-18346 |
IN |
denotes |
to |
T4388 |
18347-18350 |
DT |
denotes |
the |
T4389 |
18366-18372 |
NNS |
denotes |
limits |
T4390 |
18351-18365 |
JJ |
denotes |
psychophysical |
T4391 |
18373-18375 |
IN |
denotes |
of |
T4392 |
18376-18379 |
DT |
denotes |
the |
T4393 |
18380-18386 |
NN |
denotes |
system |
T4394 |
18387-18388 |
-LRB- |
denotes |
[ |
T4395 |
18390-18391 |
CD |
denotes |
4 |
T4396 |
18388-18389 |
CD |
denotes |
3 |
T4397 |
18389-18390 |
, |
denotes |
, |
T4398 |
18391-18392 |
-RRB- |
denotes |
] |
T4399 |
18392-18393 |
. |
denotes |
. |
T4400 |
18393-18911 |
sentence |
denotes |
Consistent with this notion, differences between GluR-BΔFB and control mice were not only larger if the detailed sampling pattern and discrimination index were investigated (Figure 2C and 2D, group effect: F(1,16) = 29.5; p < 10−4), but in particular for the discrimination of binary mixtures with similar composition (group effect: F(1,16) = 27.8; p < 10−4 for the mixture; FAA EB(1,16) = 7.0; p = 0.02, and FPel Val(1,16) = 5.8; p = 0.03 for the “simple” discrimination tasks; 3-way ANOVA: F(6,96) = 2.9; p = 0.01). |
T4401 |
18394-18404 |
JJ |
denotes |
Consistent |
T4402 |
18470-18474 |
VBD |
denotes |
were |
T4403 |
18405-18409 |
IN |
denotes |
with |
T4404 |
18410-18414 |
DT |
denotes |
this |
T4405 |
18415-18421 |
NN |
denotes |
notion |
T4406 |
18421-18423 |
, |
denotes |
, |
T4407 |
18423-18434 |
NNS |
denotes |
differences |
T4408 |
18435-18442 |
IN |
denotes |
between |
T4409 |
18443-18447 |
NN |
denotes |
GluR |
T4410 |
18448-18452 |
NN |
denotes |
BΔFB |
T4411 |
18447-18448 |
HYPH |
denotes |
- |
T4412 |
18465-18469 |
NNS |
denotes |
mice |
T4413 |
18453-18456 |
CC |
denotes |
and |
T4414 |
18457-18464 |
NN |
denotes |
control |
T4415 |
18905-18909 |
CD |
denotes |
0.01 |
T4416 |
18475-18478 |
RB |
denotes |
not |
T4417 |
18484-18490 |
JJR |
denotes |
larger |
T4418 |
18479-18483 |
RB |
denotes |
only |
T4419 |
18491-18493 |
IN |
denotes |
if |
T4420 |
18554-18566 |
VBN |
denotes |
investigated |
T4421 |
18494-18497 |
DT |
denotes |
the |
T4422 |
18516-18523 |
NN |
denotes |
pattern |
T4423 |
18498-18506 |
JJ |
denotes |
detailed |
T4424 |
18507-18515 |
NN |
denotes |
sampling |
T4425 |
18524-18527 |
CC |
denotes |
and |
T4426 |
18528-18542 |
NN |
denotes |
discrimination |
T4427 |
18543-18548 |
NN |
denotes |
index |
T4428 |
18549-18553 |
VBD |
denotes |
were |
T4429 |
18567-18568 |
-LRB- |
denotes |
( |
T4430 |
18575-18577 |
NN |
denotes |
2C |
T4431 |
18568-18574 |
NN |
denotes |
Figure |
T4432 |
18578-18581 |
CC |
denotes |
and |
T4433 |
18582-18584 |
NN |
denotes |
2D |
T4434 |
18584-18586 |
, |
denotes |
, |
T4435 |
18586-18591 |
NN |
denotes |
group |
T4436 |
18592-18598 |
NN |
denotes |
effect |
T4437 |
18623-18624 |
CD |
denotes |
4 |
T4438 |
18598-18600 |
: |
denotes |
: |
T4439 |
18600-18601 |
NN |
denotes |
F |
T4440 |
18610-18614 |
CD |
denotes |
29.5 |
T4441 |
18601-18602 |
-LRB- |
denotes |
( |
T4442 |
18602-18603 |
CD |
denotes |
1 |
T4443 |
19547-19550 |
RB |
denotes |
not |
T4444 |
18603-18604 |
, |
denotes |
, |
T4445 |
19694-19697 |
DT |
denotes |
the |
T4446 |
19966-19969 |
CC |
denotes |
and |
T4447 |
18604-18606 |
CD |
denotes |
16 |
T654 |
3179-3180 |
-RRB- |
denotes |
) |
T4448 |
18606-18607 |
-RRB- |
denotes |
) |
T4449 |
18608-18609 |
SYM |
denotes |
= |
T4450 |
18614-18615 |
: |
denotes |
; |
T4451 |
18616-18617 |
NN |
denotes |
p |
T4452 |
18618-18619 |
SYM |
denotes |
< |
T4453 |
18620-18622 |
CD |
denotes |
10 |
T4454 |
18622-18623 |
SYM |
denotes |
− |
T4455 |
18624-18625 |
-RRB- |
denotes |
) |
T4456 |
18625-18627 |
, |
denotes |
, |
T4457 |
18627-18630 |
CC |
denotes |
but |
T4458 |
18631-18633 |
IN |
denotes |
in |
T4459 |
18645-18648 |
IN |
denotes |
for |
T4460 |
18634-18644 |
JJ |
denotes |
particular |
T4461 |
18649-18652 |
DT |
denotes |
the |
T4462 |
18653-18667 |
NN |
denotes |
discrimination |
T4463 |
18668-18670 |
IN |
denotes |
of |
T4464 |
18671-18677 |
JJ |
denotes |
binary |
T4465 |
18678-18686 |
NNS |
denotes |
mixtures |
T4466 |
18687-18691 |
IN |
denotes |
with |
T4467 |
18692-18699 |
JJ |
denotes |
similar |
T4468 |
18700-18711 |
NN |
denotes |
composition |
T4469 |
18712-18713 |
-LRB- |
denotes |
( |
T4470 |
18750-18751 |
CD |
denotes |
4 |
T4471 |
18713-18718 |
NN |
denotes |
group |
T4472 |
18719-18725 |
NN |
denotes |
effect |
T4473 |
18737-18741 |
CD |
denotes |
27.8 |
T4474 |
18725-18727 |
: |
denotes |
: |
T4475 |
18727-18728 |
NN |
denotes |
F |
T4476 |
18728-18729 |
-LRB- |
denotes |
( |
T4477 |
18729-18730 |
CD |
denotes |
1 |
T4478 |
18730-18731 |
, |
denotes |
, |
T4479 |
18731-18733 |
CD |
denotes |
16 |
T4480 |
18733-18734 |
-RRB- |
denotes |
) |
T4481 |
18735-18736 |
SYM |
denotes |
= |
T4482 |
18741-18742 |
: |
denotes |
; |
T4483 |
18743-18744 |
NN |
denotes |
p |
T4484 |
18745-18746 |
SYM |
denotes |
< |
T4485 |
18747-18749 |
CD |
denotes |
10 |
T4486 |
18749-18750 |
SYM |
denotes |
− |
T4487 |
18752-18755 |
IN |
denotes |
for |
T4488 |
18756-18759 |
DT |
denotes |
the |
T4489 |
18760-18767 |
NN |
denotes |
mixture |
T4490 |
18767-18768 |
: |
denotes |
; |
T4491 |
18769-18772 |
NN |
denotes |
FAA |
T4492 |
18773-18775 |
NN |
denotes |
EB |
T4493 |
18784-18787 |
CD |
denotes |
7.0 |
T4494 |
18775-18776 |
-LRB- |
denotes |
( |
T4495 |
18776-18777 |
CD |
denotes |
1 |
T4496 |
18777-18778 |
, |
denotes |
, |
T4497 |
18778-18780 |
CD |
denotes |
16 |
T4498 |
18780-18781 |
-RRB- |
denotes |
) |
T4499 |
18782-18783 |
SYM |
denotes |
= |
T4500 |
18787-18788 |
: |
denotes |
; |
T4501 |
18789-18790 |
NN |
denotes |
p |
T4502 |
18793-18797 |
CD |
denotes |
0.02 |
T4503 |
18791-18792 |
SYM |
denotes |
= |
T4504 |
18797-18799 |
, |
denotes |
, |
T4505 |
18799-18802 |
CC |
denotes |
and |
T4506 |
18803-18807 |
NN |
denotes |
FPel |
T4507 |
18808-18811 |
NN |
denotes |
Val |
T4508 |
18820-18823 |
CD |
denotes |
5.8 |
T4509 |
18811-18812 |
-LRB- |
denotes |
( |
T4510 |
18812-18813 |
CD |
denotes |
1 |
T4511 |
18813-18814 |
, |
denotes |
, |
T4512 |
18814-18816 |
CD |
denotes |
16 |
T4513 |
18816-18817 |
-RRB- |
denotes |
) |
T4514 |
18818-18819 |
SYM |
denotes |
= |
T4515 |
18823-18824 |
: |
denotes |
; |
T4516 |
18825-18826 |
NN |
denotes |
p |
T4526 |
18871-18872 |
: |
denotes |
; |
T4517 |
18829-18833 |
CD |
denotes |
0.03 |
T4518 |
18827-18828 |
SYM |
denotes |
= |
T4519 |
18834-18837 |
IN |
denotes |
for |
T4520 |
18838-18841 |
DT |
denotes |
the |
T4521 |
18866-18871 |
NNS |
denotes |
tasks |
T4522 |
18842-18843 |
`` |
denotes |
“ |
T4523 |
18843-18849 |
JJ |
denotes |
simple |
T4524 |
18849-18850 |
'' |
denotes |
” |
T4525 |
18851-18865 |
NN |
denotes |
discrimination |
T4527 |
18873-18874 |
CD |
denotes |
3 |
T4528 |
18875-18878 |
NN |
denotes |
way |
T4529 |
18874-18875 |
HYPH |
denotes |
- |
T4530 |
18879-18884 |
NN |
denotes |
ANOVA |
T4547 |
18962-18965 |
VBD |
denotes |
was |
T4531 |
18896-18899 |
CD |
denotes |
2.9 |
T4532 |
18884-18886 |
: |
denotes |
: |
T4533 |
18886-18887 |
NN |
denotes |
F |
T4534 |
18887-18888 |
-LRB- |
denotes |
( |
T4535 |
18888-18889 |
CD |
denotes |
6 |
T4536 |
18889-18890 |
, |
denotes |
, |
T4537 |
18890-18892 |
CD |
denotes |
96 |
T4538 |
18892-18893 |
-RRB- |
denotes |
) |
T4539 |
18894-18895 |
SYM |
denotes |
= |
T4540 |
18899-18900 |
: |
denotes |
; |
T4541 |
18901-18902 |
NN |
denotes |
p |
T4542 |
18903-18904 |
SYM |
denotes |
= |
T4543 |
18909-18910 |
-RRB- |
denotes |
) |
T4544 |
18910-18911 |
. |
denotes |
. |
T4545 |
18911-19356 |
sentence |
denotes |
As activity, measured by the intertrial interval, was not significantly different between genotypes (F(1,16) = 3.1; p = 0.1), and analysis of the lick frequency showed a tendency to reduced motivation of GluR-BΔFB mice in this particular task (F(1,16) = 9.2; p < 0.01), we conclude that depletion of GluR-B in forebrain areas indeed resulted in increased olfactory learning and discrimination performances, rather than motivational alterations. |
T4546 |
18912-18914 |
IN |
denotes |
As |
T4548 |
18915-18923 |
NN |
denotes |
activity |
T4549 |
18923-18925 |
, |
denotes |
, |
T4550 |
18925-18933 |
VBN |
denotes |
measured |
T4551 |
18934-18936 |
IN |
denotes |
by |
T4552 |
18937-18940 |
DT |
denotes |
the |
T4553 |
18952-18960 |
NN |
denotes |
interval |
T4554 |
18941-18951 |
JJ |
denotes |
intertrial |
T4555 |
18960-18962 |
, |
denotes |
, |
T4556 |
19185-19193 |
VBP |
denotes |
conclude |
T4557 |
18966-18969 |
RB |
denotes |
not |
T4558 |
18970-18983 |
RB |
denotes |
significantly |
T4559 |
18984-18993 |
JJ |
denotes |
different |
T4560 |
18994-19001 |
IN |
denotes |
between |
T4561 |
19002-19011 |
NNS |
denotes |
genotypes |
T4562 |
19012-19013 |
-LRB- |
denotes |
( |
T4563 |
19032-19035 |
CD |
denotes |
0.1 |
T4564 |
19013-19014 |
NN |
denotes |
F |
T4565 |
19023-19026 |
CD |
denotes |
3.1 |
T4566 |
19014-19015 |
-LRB- |
denotes |
( |
T4567 |
19015-19016 |
CD |
denotes |
1 |
T4568 |
19016-19017 |
, |
denotes |
, |
T4569 |
19017-19019 |
CD |
denotes |
16 |
T4570 |
19019-19020 |
-RRB- |
denotes |
) |
T4571 |
19021-19022 |
SYM |
denotes |
= |
T4572 |
19026-19027 |
: |
denotes |
; |
T4573 |
19028-19029 |
NN |
denotes |
p |
T4574 |
19030-19031 |
SYM |
denotes |
= |
T4575 |
19035-19036 |
-RRB- |
denotes |
) |
T4576 |
19036-19038 |
, |
denotes |
, |
T4577 |
19038-19041 |
CC |
denotes |
and |
T4578 |
19042-19050 |
NN |
denotes |
analysis |
T4579 |
19073-19079 |
VBD |
denotes |
showed |
T4580 |
19051-19053 |
IN |
denotes |
of |
T4581 |
19054-19057 |
DT |
denotes |
the |
T4582 |
19063-19072 |
NN |
denotes |
frequency |
T4583 |
19058-19062 |
NN |
denotes |
lick |
T4584 |
19080-19081 |
DT |
denotes |
a |
T4585 |
19082-19090 |
NN |
denotes |
tendency |
T4586 |
19091-19093 |
IN |
denotes |
to |
T4587 |
19094-19101 |
VBN |
denotes |
reduced |
T4588 |
19102-19112 |
NN |
denotes |
motivation |
T4589 |
19113-19115 |
IN |
denotes |
of |
T4590 |
19116-19120 |
NN |
denotes |
GluR |
T4591 |
19121-19125 |
NN |
denotes |
BΔFB |
T4592 |
19120-19121 |
HYPH |
denotes |
- |
T4593 |
19126-19130 |
NNS |
denotes |
mice |
T4594 |
19131-19133 |
IN |
denotes |
in |
T4595 |
19134-19138 |
DT |
denotes |
this |
T4596 |
19150-19154 |
NN |
denotes |
task |
T4597 |
19139-19149 |
JJ |
denotes |
particular |
T4598 |
19155-19156 |
-LRB- |
denotes |
( |
T4613 |
19182-19184 |
PRP |
denotes |
we |
T4599 |
19175-19179 |
CD |
denotes |
0.01 |
T4600 |
19156-19157 |
NN |
denotes |
F |
T4601 |
19166-19169 |
CD |
denotes |
9.2 |
T4602 |
19157-19158 |
-LRB- |
denotes |
( |
T4603 |
19158-19159 |
CD |
denotes |
1 |
T4604 |
19159-19160 |
, |
denotes |
, |
T4605 |
19160-19162 |
CD |
denotes |
16 |
T4606 |
19162-19163 |
-RRB- |
denotes |
) |
T4607 |
19164-19165 |
SYM |
denotes |
= |
T4608 |
19169-19170 |
: |
denotes |
; |
T4609 |
19171-19172 |
NN |
denotes |
p |
T4610 |
19173-19174 |
SYM |
denotes |
< |
T4611 |
19179-19180 |
-RRB- |
denotes |
) |
T4612 |
19180-19182 |
, |
denotes |
, |
T4614 |
19194-19198 |
IN |
denotes |
that |
T4615 |
19245-19253 |
VBD |
denotes |
resulted |
T4618 |
19212-19216 |
NN |
denotes |
GluR |
T4616 |
19199-19208 |
NN |
denotes |
depletion |
T4617 |
19209-19211 |
IN |
denotes |
of |
T4619 |
19217-19218 |
NN |
denotes |
B |
T4620 |
19216-19217 |
HYPH |
denotes |
- |
T4621 |
19219-19221 |
IN |
denotes |
in |
T4622 |
19222-19231 |
NN |
denotes |
forebrain |
T4623 |
19232-19237 |
NNS |
denotes |
areas |
T4624 |
19238-19244 |
RB |
denotes |
indeed |
T4625 |
19254-19256 |
IN |
denotes |
in |
T4626 |
19257-19266 |
VBN |
denotes |
increased |
T4627 |
19305-19317 |
NNS |
denotes |
performances |
T4628 |
19267-19276 |
JJ |
denotes |
olfactory |
T4629 |
19277-19285 |
NN |
denotes |
learning |
T4630 |
19286-19289 |
CC |
denotes |
and |
T4631 |
19290-19304 |
NN |
denotes |
discrimination |
T4632 |
19317-19319 |
, |
denotes |
, |
T4633 |
19319-19325 |
RB |
denotes |
rather |
T4634 |
19326-19330 |
IN |
denotes |
than |
T4635 |
19331-19343 |
JJ |
denotes |
motivational |
T4636 |
19344-19355 |
NNS |
denotes |
alterations |
T4637 |
19355-19356 |
. |
denotes |
. |
T4638 |
19356-19517 |
sentence |
denotes |
To assess olfaction specificity, we trained ten GluR-BΔFB mice and ten controls in a nonolfactory hippocampus-dependent spatial learning task (elevated Y-maze). |
T4639 |
19357-19359 |
TO |
denotes |
To |
T4640 |
19360-19366 |
VB |
denotes |
assess |
T4641 |
19393-19400 |
VBD |
denotes |
trained |
T4642 |
19367-19376 |
NN |
denotes |
olfaction |
T4643 |
19377-19388 |
NN |
denotes |
specificity |
T4644 |
19388-19390 |
, |
denotes |
, |
T4645 |
19390-19392 |
PRP |
denotes |
we |
T4646 |
19401-19404 |
CD |
denotes |
ten |
T4647 |
19415-19419 |
NNS |
denotes |
mice |
T4648 |
19405-19409 |
NN |
denotes |
GluR |
T4649 |
19410-19414 |
NN |
denotes |
BΔFB |
T4650 |
19409-19410 |
HYPH |
denotes |
- |
T4651 |
19420-19423 |
CC |
denotes |
and |
T4652 |
19424-19427 |
CD |
denotes |
ten |
T4653 |
19428-19436 |
NNS |
denotes |
controls |
T4654 |
19437-19439 |
IN |
denotes |
in |
T4655 |
19440-19441 |
DT |
denotes |
a |
T4656 |
19494-19498 |
NN |
denotes |
task |
T4657 |
19442-19454 |
JJ |
denotes |
nonolfactory |
T4658 |
19455-19466 |
NN |
denotes |
hippocampus |
T4659 |
19467-19476 |
JJ |
denotes |
dependent |
T4660 |
19466-19467 |
HYPH |
denotes |
- |
T4661 |
19477-19484 |
JJ |
denotes |
spatial |
T4662 |
19485-19493 |
NN |
denotes |
learning |
T4663 |
19499-19500 |
-LRB- |
denotes |
( |
T4664 |
19511-19515 |
NN |
denotes |
maze |
T4665 |
19500-19508 |
VBN |
denotes |
elevated |
T4666 |
19509-19510 |
NN |
denotes |
Y |
T4667 |
19510-19511 |
HYPH |
denotes |
- |
T4668 |
19515-19516 |
-RRB- |
denotes |
) |
T4669 |
19516-19517 |
. |
denotes |
. |
T4670 |
19517-19895 |
sentence |
denotes |
Performance in this task was not improved compared with controls (Figure S2); on the contrary, the acquisition of this task was slightly impaired, allowing the conclusion that the enhanced olfactory discrimination performance is likely to be specific to the sense of smell and possibly related to enhanced discrimination capability, rather than a general increase in alertness. |
T4671 |
19518-19529 |
NN |
denotes |
Performance |
T4672 |
19551-19559 |
VBN |
denotes |
improved |
T4673 |
19530-19532 |
IN |
denotes |
in |
T4674 |
19533-19537 |
DT |
denotes |
this |
T4675 |
19538-19542 |
NN |
denotes |
task |
T4676 |
19543-19546 |
VBD |
denotes |
was |
T4677 |
19655-19663 |
VBN |
denotes |
impaired |
T4678 |
19560-19568 |
VBN |
denotes |
compared |
T4679 |
19569-19573 |
IN |
denotes |
with |
T4680 |
19574-19582 |
NNS |
denotes |
controls |
T4681 |
19583-19584 |
-LRB- |
denotes |
( |
T4682 |
19591-19593 |
NN |
denotes |
S2 |
T4683 |
19584-19590 |
NN |
denotes |
Figure |
T4684 |
19593-19594 |
-RRB- |
denotes |
) |
T4685 |
19594-19595 |
: |
denotes |
; |
T4686 |
19596-19598 |
IN |
denotes |
on |
T4687 |
19599-19602 |
DT |
denotes |
the |
T4688 |
19603-19611 |
NN |
denotes |
contrary |
T4689 |
19611-19613 |
, |
denotes |
, |
T4690 |
19613-19616 |
DT |
denotes |
the |
T4691 |
19617-19628 |
NN |
denotes |
acquisition |
T4692 |
19629-19631 |
IN |
denotes |
of |
T4693 |
19632-19636 |
DT |
denotes |
this |
T4694 |
19637-19641 |
NN |
denotes |
task |
T4695 |
19642-19645 |
VBD |
denotes |
was |
T4696 |
19646-19654 |
RB |
denotes |
slightly |
T4697 |
19663-19665 |
, |
denotes |
, |
T4699 |
19674-19677 |
DT |
denotes |
the |
T4700 |
19678-19688 |
NN |
denotes |
conclusion |
T4701 |
19689-19693 |
IN |
denotes |
that |
T4702 |
19744-19746 |
VBZ |
denotes |
is |
T4703 |
19732-19743 |
NN |
denotes |
performance |
T4704 |
19698-19706 |
VBN |
denotes |
enhanced |
T4705 |
19707-19716 |
JJ |
denotes |
olfactory |
T4706 |
19717-19731 |
NN |
denotes |
discrimination |
T4707 |
19747-19753 |
JJ |
denotes |
likely |
T4708 |
19754-19756 |
TO |
denotes |
to |
T4709 |
19757-19759 |
VB |
denotes |
be |
T4710 |
19760-19768 |
JJ |
denotes |
specific |
T4711 |
19769-19771 |
IN |
denotes |
to |
T4712 |
19772-19775 |
DT |
denotes |
the |
T4713 |
19776-19781 |
NN |
denotes |
sense |
T4714 |
19782-19784 |
IN |
denotes |
of |
T4715 |
19785-19790 |
NN |
denotes |
smell |
T4716 |
19791-19794 |
CC |
denotes |
and |
T4717 |
19795-19803 |
RB |
denotes |
possibly |
T4718 |
19804-19811 |
JJ |
denotes |
related |
T4719 |
19812-19814 |
IN |
denotes |
to |
T4720 |
19815-19823 |
VBN |
denotes |
enhanced |
T4721 |
19839-19849 |
NN |
denotes |
capability |
T4722 |
19824-19838 |
NN |
denotes |
discrimination |
T4723 |
19849-19851 |
, |
denotes |
, |
T4724 |
19851-19857 |
RB |
denotes |
rather |
T4725 |
19858-19862 |
IN |
denotes |
than |
T4726 |
19863-19864 |
DT |
denotes |
a |
T4727 |
19873-19881 |
NN |
denotes |
increase |
T4728 |
19865-19872 |
JJ |
denotes |
general |
T4729 |
19882-19884 |
IN |
denotes |
in |
T4730 |
19885-19894 |
NN |
denotes |
alertness |
T4731 |
19894-19895 |
. |
denotes |
. |
T4732 |
19895-20205 |
sentence |
denotes |
Furthermore, enhancement in odor discrimination in both GluR-BΔECS:FB and GluR-BΔFB mice makes it likely that improvement in this task results from the common AMPAR property change mediated by the depletion of GluR-B and the lack of the Q/R site-edited GluR-B subunit, both resulting in Ca2+-permeable AMPARs. |
T4733 |
19896-19907 |
RB |
denotes |
Furthermore |
T4734 |
19985-19990 |
VBZ |
denotes |
makes |
T4735 |
19907-19909 |
, |
denotes |
, |
T4736 |
19909-19920 |
NN |
denotes |
enhancement |
T4737 |
19921-19923 |
IN |
denotes |
in |
T4738 |
19924-19928 |
NN |
denotes |
odor |
T4739 |
19929-19943 |
NN |
denotes |
discrimination |
T4740 |
19944-19946 |
IN |
denotes |
in |
T4741 |
19947-19951 |
CC |
denotes |
both |
T4742 |
19957-19962 |
NN |
denotes |
BΔECS |
T4743 |
19952-19956 |
NN |
denotes |
GluR |
T4744 |
19956-19957 |
HYPH |
denotes |
- |
T4745 |
19980-19984 |
NNS |
denotes |
mice |
T4746 |
19962-19963 |
: |
denotes |
: |
T4747 |
19963-19965 |
NN |
denotes |
FB |
T4748 |
19970-19974 |
NN |
denotes |
GluR |
T4749 |
19975-19979 |
NN |
denotes |
BΔFB |
T4750 |
19974-19975 |
HYPH |
denotes |
- |
T4751 |
19991-19993 |
PRP |
denotes |
it |
T4752 |
19994-20000 |
JJ |
denotes |
likely |
T4753 |
20001-20005 |
IN |
denotes |
that |
T4754 |
20031-20038 |
VBZ |
denotes |
results |
T4755 |
20006-20017 |
NN |
denotes |
improvement |
T4756 |
20018-20020 |
IN |
denotes |
in |
T4757 |
20021-20025 |
DT |
denotes |
this |
T4758 |
20026-20030 |
NN |
denotes |
task |
T4759 |
20039-20043 |
IN |
denotes |
from |
T4760 |
20044-20047 |
DT |
denotes |
the |
T4761 |
20070-20076 |
NN |
denotes |
change |
T4762 |
20048-20054 |
JJ |
denotes |
common |
T4763 |
20055-20060 |
NN |
denotes |
AMPAR |
T4764 |
20061-20069 |
NN |
denotes |
property |
T4765 |
20077-20085 |
VBN |
denotes |
mediated |
T4766 |
20086-20088 |
IN |
denotes |
by |
T4767 |
20089-20092 |
DT |
denotes |
the |
T4768 |
20093-20102 |
NN |
denotes |
depletion |
T4769 |
20103-20105 |
IN |
denotes |
of |
T4770 |
20106-20110 |
NN |
denotes |
GluR |
T4771 |
20111-20112 |
NN |
denotes |
B |
T4772 |
20110-20111 |
HYPH |
denotes |
- |
T4773 |
20113-20116 |
CC |
denotes |
and |
T4774 |
20117-20120 |
DT |
denotes |
the |
T4775 |
20121-20125 |
NN |
denotes |
lack |
T4776 |
20126-20128 |
IN |
denotes |
of |
T4777 |
20129-20132 |
DT |
denotes |
the |
T663 |
1667-1670 |
IN |
denotes |
for |
T4778 |
20156-20163 |
NN |
denotes |
subunit |
T4779 |
20133-20134 |
NN |
denotes |
Q |
T4780 |
20135-20136 |
NN |
denotes |
R |
T4781 |
20134-20135 |
HYPH |
denotes |
/ |
T4782 |
20137-20141 |
NN |
denotes |
site |
T4783 |
20142-20148 |
VBN |
denotes |
edited |
T4784 |
20141-20142 |
HYPH |
denotes |
- |
T4785 |
20149-20153 |
NN |
denotes |
GluR |
T4786 |
20154-20155 |
NN |
denotes |
B |
T4787 |
20153-20154 |
HYPH |
denotes |
- |
T4788 |
20163-20165 |
, |
denotes |
, |
T4789 |
20165-20169 |
DT |
denotes |
both |
T4790 |
20170-20179 |
VBG |
denotes |
resulting |
T4791 |
20180-20182 |
IN |
denotes |
in |
T4792 |
20183-20186 |
NN |
denotes |
Ca2 |
T4793 |
20188-20197 |
JJ |
denotes |
permeable |
T4794 |
20186-20187 |
SYM |
denotes |
+ |
T4795 |
20187-20188 |
HYPH |
denotes |
- |
T4796 |
20198-20204 |
NNS |
denotes |
AMPARs |
T4797 |
20204-20205 |
. |
denotes |
. |
T4798 |
20205-20320 |
sentence |
denotes |
Thus, this suggests that increased Ca2+ influx via AMPARs leads to enhanced olfactory learning and discrimination. |
T4799 |
20206-20210 |
RB |
denotes |
Thus |
T4800 |
20217-20225 |
VBZ |
denotes |
suggests |
T4801 |
20210-20212 |
, |
denotes |
, |
T4802 |
20212-20216 |
DT |
denotes |
this |
T4803 |
20226-20230 |
IN |
denotes |
that |
T4804 |
20264-20269 |
VBZ |
denotes |
leads |
T4805 |
20231-20240 |
VBN |
denotes |
increased |
T4806 |
20246-20252 |
NN |
denotes |
influx |
T4807 |
20241-20244 |
NN |
denotes |
Ca2 |
T4808 |
20244-20245 |
SYM |
denotes |
+ |
T4809 |
20253-20256 |
IN |
denotes |
via |
T4810 |
20257-20263 |
NNS |
denotes |
AMPARs |
T4811 |
20270-20272 |
IN |
denotes |
to |
T4812 |
20273-20281 |
VBN |
denotes |
enhanced |
T4813 |
20292-20300 |
NN |
denotes |
learning |
T4814 |
20282-20291 |
JJ |
denotes |
olfactory |
T4815 |
20301-20304 |
CC |
denotes |
and |
T4816 |
20305-20319 |
NN |
denotes |
discrimination |
T4817 |
20319-20320 |
. |
denotes |
. |
T655 |
1621-1624 |
DT |
denotes |
The |
T656 |
1625-1630 |
NN |
denotes |
sense |
T657 |
1640-1642 |
VBZ |
denotes |
is |
T658 |
1631-1633 |
IN |
denotes |
of |
T659 |
1634-1639 |
NN |
denotes |
smell |
T660 |
1643-1645 |
IN |
denotes |
of |
T661 |
1646-1655 |
JJ |
denotes |
paramount |
T662 |
1656-1666 |
NN |
denotes |
importance |
T664 |
1671-1678 |
NNS |
denotes |
rodents |
T665 |
1679-1680 |
-LRB- |
denotes |
[ |
T666 |
1680-1681 |
CD |
denotes |
1 |
T667 |
1681-1682 |
-RRB- |
denotes |
] |
T668 |
1682-1684 |
, |
denotes |
, |
T669 |
1684-1687 |
IN |
denotes |
for |
T670 |
1754-1761 |
VBZ |
denotes |
permits |
T671 |
1688-1693 |
WDT |
denotes |
which |
T672 |
1694-1699 |
JJ |
denotes |
rapid |
T673 |
1705-1719 |
NN |
denotes |
discrimination |
T674 |
1700-1704 |
NN |
denotes |
odor |
T675 |
1720-1723 |
CC |
denotes |
and |
T676 |
1724-1728 |
RB |
denotes |
long |
T684 |
1784-1787 |
CC |
denotes |
and |
T677 |
1729-1736 |
VBG |
denotes |
lasting |
T678 |
1728-1729 |
HYPH |
denotes |
- |
T679 |
1747-1753 |
NN |
denotes |
memory |
T680 |
1737-1746 |
JJ |
denotes |
olfactory |
T681 |
1762-1771 |
NNS |
denotes |
responses |
T682 |
1772-1774 |
IN |
denotes |
to |
T683 |
1775-1783 |
NN |
denotes |
predator |
T685 |
1788-1792 |
NN |
denotes |
prey |
T686 |
1793-1801 |
JJ |
denotes |
critical |
T687 |
1802-1805 |
IN |
denotes |
for |
T688 |
1806-1814 |
NN |
denotes |
survival |
T689 |
1814-1815 |
. |
denotes |
. |
T690 |
1815-1943 |
sentence |
denotes |
Consequently, the behavioral analyses of olfactory capabilities in rodents are efficient, quantitative, and reproducible [2–4]. |
T691 |
1816-1828 |
RB |
denotes |
Consequently |
T692 |
1891-1894 |
VBP |
denotes |
are |
T693 |
1828-1830 |
, |
denotes |
, |
T694 |
1830-1833 |
DT |
denotes |
the |
T695 |
1845-1853 |
NNS |
denotes |
analyses |
T696 |
1834-1844 |
JJ |
denotes |
behavioral |
T697 |
1854-1856 |
IN |
denotes |
of |
T698 |
1857-1866 |
JJ |
denotes |
olfactory |
T699 |
1867-1879 |
NNS |
denotes |
capabilities |
T700 |
1880-1882 |
IN |
denotes |
in |
T701 |
1883-1890 |
NNS |
denotes |
rodents |
T702 |
1895-1904 |
JJ |
denotes |
efficient |
T703 |
1904-1906 |
, |
denotes |
, |
T704 |
1906-1918 |
JJ |
denotes |
quantitative |
T705 |
1918-1920 |
, |
denotes |
, |
T706 |
1920-1923 |
CC |
denotes |
and |
T707 |
1924-1936 |
JJ |
denotes |
reproducible |
T708 |
1937-1938 |
-LRB- |
denotes |
[ |
T709 |
1938-1939 |
CD |
denotes |
2 |
T710 |
1939-1940 |
SYM |
denotes |
– |
T711 |
1940-1941 |
CD |
denotes |
4 |
T712 |
1941-1942 |
-RRB- |
denotes |
] |
T713 |
1942-1943 |
. |
denotes |
. |
T714 |
1943-2165 |
sentence |
denotes |
While in the formation and storage of olfactory memory piriform cortex [5–7], hippocampus [8,9], and olfactory bulb [10–12] are all implicated, the cellular correlates for these processes have not been clearly delineated. |
T715 |
1944-1949 |
IN |
denotes |
While |
T716 |
2076-2086 |
VBN |
denotes |
implicated |
T717 |
1950-1952 |
IN |
denotes |
in |
T718 |
1953-1956 |
DT |
denotes |
the |
T719 |
1957-1966 |
NN |
denotes |
formation |
T720 |
1967-1970 |
CC |
denotes |
and |
T721 |
1971-1978 |
NN |
denotes |
storage |
T722 |
1979-1981 |
IN |
denotes |
of |
T723 |
1982-1991 |
JJ |
denotes |
olfactory |
T724 |
1992-1998 |
NN |
denotes |
memory |
T729 |
2017-2018 |
SYM |
denotes |
– |
T725 |
1999-2007 |
JJ |
denotes |
piriform |
T726 |
2008-2014 |
NN |
denotes |
cortex |
T727 |
2015-2016 |
-LRB- |
denotes |
[ |
T728 |
2016-2017 |
CD |
denotes |
5 |
T730 |
2018-2019 |
CD |
denotes |
7 |
T731 |
2019-2020 |
-RRB- |
denotes |
] |
T732 |
2020-2022 |
, |
denotes |
, |
T733 |
2022-2033 |
NN |
denotes |
hippocampus |
T734 |
2034-2035 |
-LRB- |
denotes |
[ |
T735 |
2037-2038 |
CD |
denotes |
9 |
T736 |
2035-2036 |
CD |
denotes |
8 |
T737 |
2036-2037 |
, |
denotes |
, |
T738 |
2038-2039 |
-RRB- |
denotes |
] |
T739 |
2039-2041 |
, |
denotes |
, |
T740 |
2041-2044 |
CC |
denotes |
and |
T741 |
2045-2054 |
JJ |
denotes |
olfactory |
T742 |
2055-2059 |
NN |
denotes |
bulb |
T743 |
2060-2061 |
-LRB- |
denotes |
[ |
T744 |
2061-2063 |
CD |
denotes |
10 |
T745 |
2063-2064 |
SYM |
denotes |
– |
T746 |
2064-2066 |
CD |
denotes |
12 |
T747 |
2066-2067 |
-RRB- |
denotes |
] |
T748 |
2068-2071 |
VBP |
denotes |
are |
T749 |
2072-2075 |
RB |
denotes |
all |
T756 |
2116-2121 |
DT |
denotes |
these |
T750 |
2154-2164 |
VBN |
denotes |
delineated |
T751 |
2086-2088 |
, |
denotes |
, |
T752 |
2088-2091 |
DT |
denotes |
the |
T753 |
2101-2111 |
NNS |
denotes |
correlates |
T754 |
2092-2100 |
JJ |
denotes |
cellular |
T755 |
2112-2115 |
IN |
denotes |
for |
T757 |
2122-2131 |
NNS |
denotes |
processes |
T758 |
2132-2136 |
VBP |
denotes |
have |
T759 |
2137-2140 |
RB |
denotes |
not |
T760 |
2141-2145 |
VBN |
denotes |
been |
T761 |
2146-2153 |
RB |
denotes |
clearly |
T762 |
2164-2165 |
. |
denotes |
. |
T763 |
2165-2332 |
sentence |
denotes |
The contribution of the hippocampus to olfactory memory is presently controversial [2,13–18], but is deemed unlikely for simple olfactory discrimination tasks [9,19]. |
T764 |
2166-2169 |
DT |
denotes |
The |
T765 |
2170-2182 |
NN |
denotes |
contribution |
T766 |
2222-2224 |
VBZ |
denotes |
is |
T767 |
2183-2185 |
IN |
denotes |
of |
T768 |
2186-2189 |
DT |
denotes |
the |
T769 |
2190-2201 |
NN |
denotes |
hippocampus |
T770 |
2202-2204 |
IN |
denotes |
to |
T771 |
2205-2214 |
JJ |
denotes |
olfactory |
T772 |
2215-2221 |
NN |
denotes |
memory |
T773 |
2225-2234 |
RB |
denotes |
presently |
T774 |
2235-2248 |
JJ |
denotes |
controversial |
T775 |
2249-2250 |
-LRB- |
denotes |
[ |
T776 |
2250-2251 |
CD |
denotes |
2 |
T777 |
2251-2252 |
, |
denotes |
, |
T778 |
2252-2254 |
CD |
denotes |
13 |
T779 |
2254-2255 |
SYM |
denotes |
– |
T780 |
2255-2257 |
CD |
denotes |
18 |
T781 |
2257-2258 |
-RRB- |
denotes |
] |
T782 |
2258-2260 |
, |
denotes |
, |
T783 |
2260-2263 |
CC |
denotes |
but |
T784 |
2264-2266 |
VBZ |
denotes |
is |
T785 |
2267-2273 |
VBN |
denotes |
deemed |
T786 |
2274-2282 |
JJ |
denotes |
unlikely |
T787 |
2283-2286 |
IN |
denotes |
for |
T788 |
2287-2293 |
JJ |
denotes |
simple |
T789 |
2319-2324 |
NNS |
denotes |
tasks |
T790 |
2294-2303 |
JJ |
denotes |
olfactory |
T791 |
2304-2318 |
NN |
denotes |
discrimination |
T792 |
2325-2326 |
-LRB- |
denotes |
[ |
T793 |
2328-2330 |
CD |
denotes |
19 |
T794 |
2326-2327 |
CD |
denotes |
9 |
T795 |
2327-2328 |
, |
denotes |
, |
T796 |
2330-2331 |
-RRB- |
denotes |
] |
T797 |
2331-2332 |
. |
denotes |
. |
T798 |
2332-2599 |
sentence |
denotes |
In fact, the most likely candidates for a cellular correlate of olfactory memory appear to be the neuronal connections in the piriform cortex due to the associational connectivity [5] and the expression of several forms of cellular and synaptic plasticity [7,20–23]. |
T799 |
2333-2335 |
IN |
denotes |
In |
T800 |
2414-2420 |
VBP |
denotes |
appear |
T801 |
2336-2340 |
NN |
denotes |
fact |
T802 |
2340-2342 |
, |
denotes |
, |
T803 |
2342-2345 |
DT |
denotes |
the |
T804 |
2358-2368 |
NNS |
denotes |
candidates |
T805 |
2346-2350 |
RBS |
denotes |
most |
T806 |
2351-2357 |
JJ |
denotes |
likely |
T807 |
2369-2372 |
IN |
denotes |
for |
T808 |
2373-2374 |
DT |
denotes |
a |
T809 |
2384-2393 |
NN |
denotes |
correlate |
T810 |
2375-2383 |
JJ |
denotes |
cellular |
T811 |
2394-2396 |
IN |
denotes |
of |
T812 |
2397-2406 |
JJ |
denotes |
olfactory |
T813 |
2407-2413 |
NN |
denotes |
memory |
T814 |
2421-2423 |
TO |
denotes |
to |
T815 |
2424-2426 |
VB |
denotes |
be |
T816 |
2427-2430 |
DT |
denotes |
the |
T817 |
2440-2451 |
NNS |
denotes |
connections |
T818 |
2431-2439 |
JJ |
denotes |
neuronal |
T819 |
2452-2454 |
IN |
denotes |
in |
T820 |
2455-2458 |
DT |
denotes |
the |
T821 |
2468-2474 |
NN |
denotes |
cortex |
T822 |
2459-2467 |
JJ |
denotes |
piriform |
T823 |
2475-2478 |
IN |
denotes |
due |
T824 |
2479-2481 |
IN |
denotes |
to |
T825 |
2482-2485 |
DT |
denotes |
the |
T826 |
2500-2512 |
NN |
denotes |
connectivity |
T827 |
2486-2499 |
JJ |
denotes |
associational |
T828 |
2513-2514 |
-LRB- |
denotes |
[ |
T829 |
2514-2515 |
CD |
denotes |
5 |
T830 |
2515-2516 |
-RRB- |
denotes |
] |
T831 |
2517-2520 |
CC |
denotes |
and |
T832 |
2521-2524 |
DT |
denotes |
the |
T833 |
2525-2535 |
NN |
denotes |
expression |
T834 |
2536-2538 |
IN |
denotes |
of |
T835 |
2539-2546 |
JJ |
denotes |
several |
T836 |
2547-2552 |
NNS |
denotes |
forms |
T837 |
2553-2555 |
IN |
denotes |
of |
T838 |
2556-2564 |
JJ |
denotes |
cellular |
T839 |
2578-2588 |
NN |
denotes |
plasticity |
T840 |
2565-2568 |
CC |
denotes |
and |
T841 |
2569-2577 |
JJ |
denotes |
synaptic |
T842 |
2589-2590 |
-LRB- |
denotes |
[ |
T843 |
2590-2591 |
CD |
denotes |
7 |
T844 |
2591-2592 |
, |
denotes |
, |
T845 |
2592-2594 |
CD |
denotes |
20 |
T846 |
2594-2595 |
SYM |
denotes |
– |
T847 |
2595-2597 |
CD |
denotes |
23 |
T848 |
2597-2598 |
-RRB- |
denotes |
] |
T849 |
2598-2599 |
. |
denotes |
. |
T850 |
2599-2778 |
sentence |
denotes |
Concerning odor discrimination itself, cellular mechanisms for this process are often attributed to the inhibitory circuitry of the olfactory bulb ([24–30]; reviewed in [31–33]). |
T851 |
2600-2610 |
VBG |
denotes |
Concerning |
T852 |
2686-2696 |
VBN |
denotes |
attributed |
T853 |
2611-2615 |
NN |
denotes |
odor |
T854 |
2616-2630 |
NN |
denotes |
discrimination |
T855 |
2631-2637 |
PRP |
denotes |
itself |
T856 |
2637-2639 |
, |
denotes |
, |
T857 |
2639-2647 |
JJ |
denotes |
cellular |
T858 |
2648-2658 |
NNS |
denotes |
mechanisms |
T859 |
2659-2662 |
IN |
denotes |
for |
T860 |
2663-2667 |
DT |
denotes |
this |
T861 |
2668-2675 |
NN |
denotes |
process |
T862 |
2676-2679 |
VBP |
denotes |
are |
T863 |
2680-2685 |
RB |
denotes |
often |
T864 |
2697-2699 |
IN |
denotes |
to |
T865 |
2700-2703 |
DT |
denotes |
the |
T866 |
2715-2724 |
NN |
denotes |
circuitry |
T867 |
2704-2714 |
JJ |
denotes |
inhibitory |
T868 |
2725-2727 |
IN |
denotes |
of |
T869 |
2728-2731 |
DT |
denotes |
the |
T870 |
2742-2746 |
NN |
denotes |
bulb |
T871 |
2732-2741 |
JJ |
denotes |
olfactory |
T872 |
2747-2748 |
-LRB- |
denotes |
( |
T873 |
2757-2765 |
VBN |
denotes |
reviewed |
T874 |
2748-2749 |
-LRB- |
denotes |
[ |
T875 |
2749-2751 |
CD |
denotes |
24 |
T876 |
2751-2752 |
SYM |
denotes |
– |
T877 |
2752-2754 |
CD |
denotes |
30 |
T878 |
2754-2755 |
-RRB- |
denotes |
] |
T879 |
2755-2756 |
: |
denotes |
; |
T880 |
2766-2768 |
IN |
denotes |
in |
T881 |
2769-2770 |
-LRB- |
denotes |
[ |
T882 |
2770-2772 |
CD |
denotes |
31 |
T883 |
2772-2773 |
SYM |
denotes |
– |
T884 |
2773-2775 |
CD |
denotes |
33 |
T885 |
2775-2776 |
-RRB- |
denotes |
] |
T886 |
2776-2777 |
-RRB- |
denotes |
) |
T887 |
2777-2778 |
. |
denotes |
. |
T888 |
2778-3022 |
sentence |
denotes |
Lateral inhibitory circuits were postulated, in analogy to retina [34,35], to mediate contrast enhancement [24], for which physiological recordings [24,36,37] and modeling data, based on the well-known anatomy [29], provide additional support. |
T889 |
2779-2786 |
JJ |
denotes |
Lateral |
T890 |
2798-2806 |
NNS |
denotes |
circuits |
T891 |
2787-2797 |
JJ |
denotes |
inhibitory |
T892 |
2812-2822 |
VBN |
denotes |
postulated |
T893 |
2807-2811 |
VBD |
denotes |
were |
T894 |
2822-2824 |
, |
denotes |
, |
T895 |
2824-2826 |
IN |
denotes |
in |
T896 |
2827-2834 |
NN |
denotes |
analogy |
T897 |
2835-2837 |
IN |
denotes |
to |
T898 |
2838-2844 |
NN |
denotes |
retina |
T899 |
2845-2846 |
-LRB- |
denotes |
[ |
T900 |
2849-2851 |
CD |
denotes |
35 |
T901 |
2846-2848 |
CD |
denotes |
34 |
T902 |
2848-2849 |
, |
denotes |
, |
T903 |
2851-2852 |
-RRB- |
denotes |
] |
T904 |
2852-2854 |
, |
denotes |
, |
T905 |
2854-2856 |
TO |
denotes |
to |
T906 |
2857-2864 |
VB |
denotes |
mediate |
T932 |
2981-2988 |
NN |
denotes |
anatomy |
T907 |
2865-2873 |
NN |
denotes |
contrast |
T908 |
2874-2885 |
NN |
denotes |
enhancement |
T909 |
2886-2887 |
-LRB- |
denotes |
[ |
T1017 |
3470-3475 |
NN |
denotes |
gamma |
T910 |
2887-2889 |
CD |
denotes |
24 |
T911 |
2889-2890 |
-RRB- |
denotes |
] |
T912 |
2890-2892 |
, |
denotes |
, |
T913 |
2892-2895 |
IN |
denotes |
for |
T914 |
2995-3002 |
VBP |
denotes |
provide |
T915 |
2896-2901 |
WDT |
denotes |
which |
T916 |
2902-2915 |
JJ |
denotes |
physiological |
T917 |
2916-2926 |
NNS |
denotes |
recordings |
T918 |
2927-2928 |
-LRB- |
denotes |
[ |
T919 |
2934-2936 |
CD |
denotes |
37 |
T920 |
2928-2930 |
CD |
denotes |
24 |
T921 |
2930-2931 |
, |
denotes |
, |
T922 |
2931-2933 |
CD |
denotes |
36 |
T923 |
2933-2934 |
, |
denotes |
, |
T924 |
2936-2937 |
-RRB- |
denotes |
] |
T925 |
2938-2941 |
CC |
denotes |
and |
T926 |
2942-2950 |
NN |
denotes |
modeling |
T927 |
2951-2955 |
NNS |
denotes |
data |
T928 |
2955-2957 |
, |
denotes |
, |
T929 |
2957-2962 |
VBN |
denotes |
based |
T930 |
2963-2965 |
IN |
denotes |
on |
T931 |
2966-2969 |
DT |
denotes |
the |
T933 |
2970-2974 |
RB |
denotes |
well |
T934 |
2975-2980 |
VBN |
denotes |
known |
T935 |
2974-2975 |
HYPH |
denotes |
- |
T936 |
2989-2990 |
-LRB- |
denotes |
[ |
T937 |
2990-2992 |
CD |
denotes |
29 |
T938 |
2992-2993 |
-RRB- |
denotes |
] |
T939 |
2993-2995 |
, |
denotes |
, |
T940 |
3003-3013 |
JJ |
denotes |
additional |
T941 |
3014-3021 |
NN |
denotes |
support |
T942 |
3021-3022 |
. |
denotes |
. |
T943 |
3022-3248 |
sentence |
denotes |
Such contrast enhancement may rest in large part on the particular properties of dendrodendritic synapses between the principal output neurons (mitral cells) and local inhibitory neurons (granule cells) of the olfactory bulb. |
T944 |
3023-3027 |
JJ |
denotes |
Such |
T945 |
3037-3048 |
NN |
denotes |
enhancement |
T946 |
3028-3036 |
NN |
denotes |
contrast |
T947 |
3053-3057 |
VB |
denotes |
rest |
T948 |
3049-3052 |
MD |
denotes |
may |
T949 |
3058-3060 |
IN |
denotes |
in |
T950 |
3061-3066 |
JJ |
denotes |
large |
T951 |
3067-3071 |
NN |
denotes |
part |
T952 |
3072-3074 |
IN |
denotes |
on |
T953 |
3075-3078 |
DT |
denotes |
the |
T954 |
3090-3100 |
NNS |
denotes |
properties |
T955 |
3079-3089 |
JJ |
denotes |
particular |
T956 |
3101-3103 |
IN |
denotes |
of |
T957 |
3104-3119 |
JJ |
denotes |
dendrodendritic |
T958 |
3120-3128 |
NNS |
denotes |
synapses |
T959 |
3129-3136 |
IN |
denotes |
between |
T960 |
3137-3140 |
DT |
denotes |
the |
T961 |
3158-3165 |
NNS |
denotes |
neurons |
T962 |
3141-3150 |
JJ |
denotes |
principal |
T963 |
3151-3157 |
NN |
denotes |
output |
T964 |
3166-3167 |
-LRB- |
denotes |
( |
T965 |
3174-3179 |
NNS |
denotes |
cells |
T966 |
3167-3173 |
JJ |
denotes |
mitral |
T967 |
3181-3184 |
CC |
denotes |
and |
T968 |
3185-3190 |
JJ |
denotes |
local |
T969 |
3202-3209 |
NNS |
denotes |
neurons |
T970 |
3191-3201 |
JJ |
denotes |
inhibitory |
T971 |
3210-3211 |
-LRB- |
denotes |
( |
T972 |
3219-3224 |
NNS |
denotes |
cells |
T973 |
3211-3218 |
NN |
denotes |
granule |
T974 |
3224-3225 |
-RRB- |
denotes |
) |
T975 |
3226-3228 |
IN |
denotes |
of |
T976 |
3229-3232 |
DT |
denotes |
the |
T977 |
3243-3247 |
NN |
denotes |
bulb |
T978 |
3233-3242 |
JJ |
denotes |
olfactory |
T979 |
3247-3248 |
. |
denotes |
. |
T980 |
3248-3581 |
sentence |
denotes |
In these distinct synapses, lateral and recurrent inhibition mediated by the gamma-aminobutyric acid-A system may be controlled by the activity of the closely appositioned glutamatergic part, perhaps triggering increased gamma-aminobutyric acid release by Ca2+ influx through glutamate-gated receptor channels ([38]; see also [39]). |
T981 |
3249-3251 |
IN |
denotes |
In |
T982 |
3366-3376 |
VBN |
denotes |
controlled |
T983 |
3252-3257 |
DT |
denotes |
these |
T984 |
3267-3275 |
NNS |
denotes |
synapses |
T985 |
3258-3266 |
JJ |
denotes |
distinct |
T986 |
3275-3277 |
, |
denotes |
, |
T987 |
3277-3284 |
JJ |
denotes |
lateral |
T988 |
3299-3309 |
NN |
denotes |
inhibition |
T989 |
3285-3288 |
CC |
denotes |
and |
T990 |
3289-3298 |
JJ |
denotes |
recurrent |
T991 |
3310-3318 |
VBN |
denotes |
mediated |
T992 |
3319-3321 |
IN |
denotes |
by |
T993 |
3322-3325 |
DT |
denotes |
the |
T994 |
3352-3358 |
NN |
denotes |
system |
T995 |
3326-3331 |
NN |
denotes |
gamma |
T996 |
3332-3344 |
JJ |
denotes |
aminobutyric |
T997 |
3331-3332 |
HYPH |
denotes |
- |
T998 |
3345-3349 |
NN |
denotes |
acid |
T999 |
3350-3351 |
NN |
denotes |
A |
T1000 |
3349-3350 |
HYPH |
denotes |
- |
T1001 |
3359-3362 |
MD |
denotes |
may |
T1002 |
3363-3365 |
VB |
denotes |
be |
T1003 |
3377-3379 |
IN |
denotes |
by |
T1004 |
3380-3383 |
DT |
denotes |
the |
T1005 |
3384-3392 |
NN |
denotes |
activity |
T1006 |
3393-3395 |
IN |
denotes |
of |
T1007 |
3396-3399 |
DT |
denotes |
the |
T1008 |
3435-3439 |
NN |
denotes |
part |
T1009 |
3400-3407 |
RB |
denotes |
closely |
T1010 |
3408-3420 |
VBN |
denotes |
appositioned |
T1011 |
3421-3434 |
JJ |
denotes |
glutamatergic |
T1012 |
3439-3441 |
, |
denotes |
, |
T1013 |
3441-3448 |
RB |
denotes |
perhaps |
T1014 |
3449-3459 |
VBG |
denotes |
triggering |
T1015 |
3460-3469 |
VBN |
denotes |
increased |
T1016 |
3494-3501 |
NN |
denotes |
release |
T1018 |
3476-3488 |
JJ |
denotes |
aminobutyric |
T1019 |
3475-3476 |
HYPH |
denotes |
- |
T1020 |
3489-3493 |
NN |
denotes |
acid |
T1021 |
3502-3504 |
IN |
denotes |
by |
T1022 |
3505-3508 |
NN |
denotes |
Ca2 |
T1023 |
3510-3516 |
NN |
denotes |
influx |
T1024 |
3508-3509 |
SYM |
denotes |
+ |
T1025 |
3517-3524 |
IN |
denotes |
through |
T1026 |
3525-3534 |
NN |
denotes |
glutamate |
T1027 |
3535-3540 |
VBN |
denotes |
gated |
T1028 |
3534-3535 |
HYPH |
denotes |
- |
T1029 |
3550-3558 |
NNS |
denotes |
channels |
T1030 |
3541-3549 |
NN |
denotes |
receptor |
T1031 |
3559-3560 |
-LRB- |
denotes |
( |
T1032 |
3561-3563 |
CD |
denotes |
38 |
T1033 |
3560-3561 |
-LRB- |
denotes |
[ |
T1034 |
3563-3564 |
-RRB- |
denotes |
] |
T1035 |
3564-3565 |
: |
denotes |
; |
T1036 |
3566-3569 |
VB |
denotes |
see |
T1037 |
3570-3574 |
RB |
denotes |
also |
T1038 |
3575-3576 |
-LRB- |
denotes |
[ |
T1039 |
3576-3578 |
CD |
denotes |
39 |
T1040 |
3578-3579 |
-RRB- |
denotes |
] |
T1041 |
3579-3580 |
-RRB- |
denotes |
) |
T1042 |
3580-3581 |
. |
denotes |
. |
T1043 |
3581-3991 |
sentence |
denotes |
Given that neuronal circuits underlying odor discrimination, as well as olfactory memory, rely on properties of fast excitatory neurotransmission mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs), we sought to alter, by genetic means, the specific functional contribution of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) channels containing the dominant subunit GluR-B. |
T1044 |
3582-3587 |
VBN |
denotes |
Given |
T1045 |
3812-3818 |
VBD |
denotes |
sought |
T1046 |
3588-3592 |
IN |
denotes |
that |
T1047 |
3672-3676 |
VBP |
denotes |
rely |
T1048 |
3593-3601 |
JJ |
denotes |
neuronal |
T1049 |
3602-3610 |
NNS |
denotes |
circuits |
T1050 |
3611-3621 |
VBG |
denotes |
underlying |
T1051 |
3622-3626 |
NN |
denotes |
odor |
T1052 |
3627-3641 |
NN |
denotes |
discrimination |
T1053 |
3641-3643 |
, |
denotes |
, |
T1054 |
3643-3645 |
RB |
denotes |
as |
T1055 |
3651-3653 |
IN |
denotes |
as |
T1056 |
3646-3650 |
RB |
denotes |
well |
T1057 |
3654-3663 |
JJ |
denotes |
olfactory |
T1058 |
3664-3670 |
NN |
denotes |
memory |
T1059 |
3670-3672 |
, |
denotes |
, |
T1060 |
3677-3679 |
IN |
denotes |
on |
T1061 |
3680-3690 |
NNS |
denotes |
properties |
T1062 |
3691-3693 |
IN |
denotes |
of |
T1063 |
3694-3698 |
JJ |
denotes |
fast |
T1064 |
3710-3727 |
NN |
denotes |
neurotransmission |
T1065 |
3699-3709 |
JJ |
denotes |
excitatory |
T1066 |
3728-3736 |
VBN |
denotes |
mediated |
T1067 |
3737-3739 |
IN |
denotes |
by |
T1068 |
3740-3741 |
NN |
denotes |
α |
T1069 |
3742-3747 |
NN |
denotes |
amino |
T1070 |
3741-3742 |
HYPH |
denotes |
- |
T1071 |
3769-3788 |
NN |
denotes |
isoxazolepropionate |
T1072 |
3747-3748 |
HYPH |
denotes |
- |
T1073 |
3748-3749 |
CD |
denotes |
3 |
T1074 |
3750-3757 |
NN |
denotes |
hydroxy |
T1075 |
3749-3750 |
HYPH |
denotes |
- |
T1117 |
3936-3937 |
-LRB- |
denotes |
( |
T1076 |
3757-3758 |
HYPH |
denotes |
- |
T1077 |
3758-3759 |
CD |
denotes |
5 |
T1078 |
3760-3766 |
NN |
denotes |
methyl |
T1079 |
3759-3760 |
HYPH |
denotes |
- |
T1080 |
3766-3767 |
HYPH |
denotes |
- |
T1081 |
3767-3768 |
CD |
denotes |
4 |
T1082 |
3768-3769 |
HYPH |
denotes |
- |
T1083 |
3789-3798 |
NNS |
denotes |
receptors |
T1084 |
3799-3800 |
-LRB- |
denotes |
( |
T1085 |
3800-3806 |
NNS |
denotes |
AMPARs |
T1086 |
3806-3807 |
-RRB- |
denotes |
) |
T1087 |
3807-3809 |
, |
denotes |
, |
T1088 |
3809-3811 |
PRP |
denotes |
we |
T1089 |
3819-3821 |
TO |
denotes |
to |
T1090 |
3822-3827 |
VB |
denotes |
alter |
T1091 |
3827-3829 |
, |
denotes |
, |
T1092 |
3829-3831 |
IN |
denotes |
by |
T1093 |
3832-3839 |
JJ |
denotes |
genetic |
T1094 |
3840-3845 |
NNS |
denotes |
means |
T1095 |
3845-3847 |
, |
denotes |
, |
T1096 |
3847-3850 |
DT |
denotes |
the |
T1097 |
3871-3883 |
NN |
denotes |
contribution |
T1098 |
3851-3859 |
JJ |
denotes |
specific |
T1099 |
3860-3870 |
JJ |
denotes |
functional |
T1100 |
3884-3886 |
IN |
denotes |
of |
T1101 |
3887-3888 |
NN |
denotes |
α |
T1102 |
3889-3894 |
NN |
denotes |
amino |
T1103 |
3888-3889 |
HYPH |
denotes |
- |
T1104 |
3916-3935 |
NN |
denotes |
isoxazolepropionate |
T1105 |
3894-3895 |
HYPH |
denotes |
- |
T1106 |
3895-3896 |
CD |
denotes |
3 |
T1107 |
3897-3904 |
NN |
denotes |
hydroxy |
T1108 |
3896-3897 |
HYPH |
denotes |
- |
T1109 |
3904-3905 |
HYPH |
denotes |
- |
T1110 |
3905-3906 |
CD |
denotes |
5 |
T1111 |
3907-3913 |
NN |
denotes |
methyl |
T1112 |
3906-3907 |
HYPH |
denotes |
- |
T1113 |
3913-3914 |
HYPH |
denotes |
- |
T1114 |
3914-3915 |
CD |
denotes |
4 |
T1115 |
3915-3916 |
HYPH |
denotes |
- |
T1116 |
3943-3951 |
NNS |
denotes |
channels |
T1118 |
3937-3941 |
NN |
denotes |
AMPA |
T1119 |
3941-3942 |
-RRB- |
denotes |
) |
T1120 |
3952-3962 |
VBG |
denotes |
containing |
T1121 |
3963-3966 |
DT |
denotes |
the |
T1122 |
3976-3983 |
NN |
denotes |
subunit |
T1123 |
3967-3975 |
JJ |
denotes |
dominant |
T1124 |
3984-3988 |
NN |
denotes |
GluR |
T1125 |
3989-3990 |
NN |
denotes |
B |
T1126 |
3988-3989 |
HYPH |
denotes |
- |
T1127 |
3990-3991 |
. |
denotes |
. |
T1128 |
3991-4171 |
sentence |
denotes |
Of the four AMPAR constituents, GluR-A to D (GluR1 to 4), which form tetrameric channels with different binary subunit combinations, GluR-B is contained in the majority of AMPARs. |
T1129 |
3992-3994 |
IN |
denotes |
Of |
T1130 |
4135-4144 |
VBN |
denotes |
contained |
T1131 |
3995-3998 |
DT |
denotes |
the |
T1132 |
4010-4022 |
NNS |
denotes |
constituents |
T1133 |
3999-4003 |
CD |
denotes |
four |
T1134 |
4004-4009 |
NN |
denotes |
AMPAR |
T1135 |
4022-4024 |
, |
denotes |
, |
T1136 |
4024-4028 |
NN |
denotes |
GluR |
T1137 |
4029-4030 |
NN |
denotes |
A |
T1138 |
4028-4029 |
HYPH |
denotes |
- |
T1139 |
4031-4033 |
IN |
denotes |
to |
T1140 |
4034-4035 |
NN |
denotes |
D |
T1141 |
4036-4037 |
-LRB- |
denotes |
( |
T1142 |
4037-4042 |
NN |
denotes |
GluR1 |
T1143 |
4043-4045 |
IN |
denotes |
to |
T1144 |
4046-4047 |
CD |
denotes |
4 |
T1145 |
4047-4048 |
-RRB- |
denotes |
) |
T1146 |
4048-4050 |
, |
denotes |
, |
T1147 |
4050-4055 |
WDT |
denotes |
which |
T1148 |
4056-4060 |
VBP |
denotes |
form |
T1149 |
4061-4071 |
JJ |
denotes |
tetrameric |
T1150 |
4072-4080 |
NNS |
denotes |
channels |
T1151 |
4081-4085 |
IN |
denotes |
with |
T1152 |
4086-4095 |
JJ |
denotes |
different |
T1153 |
4111-4123 |
NNS |
denotes |
combinations |
T1154 |
4096-4102 |
JJ |
denotes |
binary |
T1155 |
4103-4110 |
NN |
denotes |
subunit |
T1156 |
4123-4125 |
, |
denotes |
, |
T1157 |
4125-4129 |
NN |
denotes |
GluR |
T1158 |
4130-4131 |
NN |
denotes |
B |
T1159 |
4129-4130 |
HYPH |
denotes |
- |
T1160 |
4132-4134 |
VBZ |
denotes |
is |
T1161 |
4145-4147 |
IN |
denotes |
in |
T1162 |
4148-4151 |
DT |
denotes |
the |
T1163 |
4152-4160 |
NN |
denotes |
majority |
T1164 |
4161-4163 |
IN |
denotes |
of |
T1165 |
4164-4170 |
NNS |
denotes |
AMPARs |
T1166 |
4170-4171 |
. |
denotes |
. |
T1216 |
4398-4404 |
RB |
denotes |
solely |
T1167 |
4171-4312 |
sentence |
denotes |
GluR-B is critically involved in the formation and trafficking of AMPARs, and dominates their ion conductance and gating properties [40–46]. |
T1168 |
4172-4176 |
NN |
denotes |
GluR |
T1169 |
4177-4178 |
NN |
denotes |
B |
T1170 |
4176-4177 |
HYPH |
denotes |
- |
T1171 |
4193-4201 |
VBN |
denotes |
involved |
T1172 |
4179-4181 |
VBZ |
denotes |
is |
T1173 |
4182-4192 |
RB |
denotes |
critically |
T1174 |
4202-4204 |
IN |
denotes |
in |
T1175 |
4205-4208 |
DT |
denotes |
the |
T1176 |
4209-4218 |
NN |
denotes |
formation |
T1177 |
4219-4222 |
CC |
denotes |
and |
T1178 |
4223-4234 |
NN |
denotes |
trafficking |
T1179 |
4235-4237 |
IN |
denotes |
of |
T1180 |
4238-4244 |
NNS |
denotes |
AMPARs |
T1181 |
4244-4246 |
, |
denotes |
, |
T1182 |
4246-4249 |
CC |
denotes |
and |
T1183 |
4250-4259 |
VBZ |
denotes |
dominates |
T1184 |
4260-4265 |
PRP$ |
denotes |
their |
T1185 |
4270-4281 |
NN |
denotes |
conductance |
T1186 |
4266-4269 |
NN |
denotes |
ion |
T1187 |
4282-4285 |
CC |
denotes |
and |
T1188 |
4286-4292 |
NN |
denotes |
gating |
T1189 |
4293-4303 |
NNS |
denotes |
properties |
T1190 |
4304-4305 |
-LRB- |
denotes |
[ |
T1191 |
4305-4307 |
CD |
denotes |
40 |
T1192 |
4307-4308 |
SYM |
denotes |
– |
T1193 |
4308-4310 |
CD |
denotes |
46 |
T1194 |
4310-4311 |
-RRB- |
denotes |
] |
T1195 |
4311-4312 |
. |
denotes |
. |
T1196 |
4312-4638 |
sentence |
denotes |
Notably, the normally low Ca2+ permeability of AMPA channels in principal neurons is solely mediated by GluR-B, due to a unique arginine residue (R587) in the functionally critical glutamine/arginine (Q/R) site of the pore-forming segment M2 [44,47,48], resulting from RNA editing of GluR-B pre-mRNA ([49]; reviewed in [50]). |
T1197 |
4313-4320 |
RB |
denotes |
Notably |
T1198 |
4405-4413 |
VBN |
denotes |
mediated |
T1902 |
7834-7837 |
CC |
denotes |
and |
T1199 |
4320-4322 |
, |
denotes |
, |
T1200 |
4322-4325 |
DT |
denotes |
the |
T1201 |
4344-4356 |
NN |
denotes |
permeability |
T1202 |
4326-4334 |
RB |
denotes |
normally |
T1203 |
4335-4338 |
JJ |
denotes |
low |
T1204 |
4339-4342 |
NN |
denotes |
Ca2 |
T1205 |
4342-4343 |
SYM |
denotes |
+ |
T1206 |
4357-4359 |
IN |
denotes |
of |
T1207 |
4360-4364 |
NN |
denotes |
AMPA |
T1208 |
4365-4373 |
NNS |
denotes |
channels |
T1209 |
4485-4493 |
JJ |
denotes |
critical |
T1210 |
4374-4376 |
IN |
denotes |
in |
T1211 |
5044-5046 |
IN |
denotes |
of |
T1212 |
4377-4386 |
JJ |
denotes |
principal |
T1213 |
5366-5374 |
JJ |
denotes |
synaptic |
T1214 |
4387-4394 |
NNS |
denotes |
neurons |
T1215 |
4395-4397 |
VBZ |
denotes |
is |
T1217 |
4414-4416 |
IN |
denotes |
by |
T1218 |
6401-6403 |
CD |
denotes |
55 |
T1219 |
4417-4421 |
NN |
denotes |
GluR |
T1220 |
4422-4423 |
NN |
denotes |
B |
T1221 |
4421-4422 |
HYPH |
denotes |
- |
T1222 |
4423-4425 |
, |
denotes |
, |
T1223 |
6869-6871 |
, |
denotes |
, |
T1224 |
4425-4428 |
IN |
denotes |
due |
T1225 |
4429-4431 |
IN |
denotes |
to |
T1226 |
7578-7579 |
`` |
denotes |
“ |
T1227 |
4432-4433 |
DT |
denotes |
a |
T1228 |
4450-4457 |
NN |
denotes |
residue |
T1229 |
4434-4440 |
JJ |
denotes |
unique |
T1230 |
4441-4449 |
NN |
denotes |
arginine |
T1231 |
4458-4459 |
-LRB- |
denotes |
( |
T1232 |
4459-4463 |
NN |
denotes |
R587 |
T1233 |
4463-4464 |
-RRB- |
denotes |
) |
T1234 |
4465-4467 |
IN |
denotes |
in |
T1235 |
4468-4471 |
DT |
denotes |
the |
T1236 |
4519-4523 |
NN |
denotes |
site |
T1237 |
4472-4484 |
RB |
denotes |
functionally |
T1238 |
4494-4503 |
NN |
denotes |
glutamine |
T1239 |
4504-4512 |
NN |
denotes |
arginine |
T1240 |
4503-4504 |
HYPH |
denotes |
/ |
T1241 |
4513-4514 |
-LRB- |
denotes |
( |
T1242 |
4516-4517 |
NN |
denotes |
R |
T1243 |
4514-4515 |
NN |
denotes |
Q |
T1340 |
4884-4885 |
-RRB- |
denotes |
] |
T1244 |
4515-4516 |
HYPH |
denotes |
/ |
T1245 |
4517-4518 |
-RRB- |
denotes |
) |
T1246 |
4524-4526 |
IN |
denotes |
of |
T1247 |
4527-4530 |
DT |
denotes |
the |
T1248 |
4552-4554 |
NN |
denotes |
M2 |
T1249 |
4531-4535 |
NN |
denotes |
pore |
T1250 |
4536-4543 |
VBG |
denotes |
forming |
T1251 |
4535-4536 |
HYPH |
denotes |
- |
T1252 |
4544-4551 |
NN |
denotes |
segment |
T1253 |
4555-4556 |
-LRB- |
denotes |
[ |
T1254 |
4562-4564 |
CD |
denotes |
48 |
T1255 |
4556-4558 |
CD |
denotes |
44 |
T1256 |
4558-4559 |
, |
denotes |
, |
T1257 |
4559-4561 |
CD |
denotes |
47 |
T1258 |
4561-4562 |
, |
denotes |
, |
T1259 |
4564-4565 |
-RRB- |
denotes |
] |
T1260 |
4565-4567 |
, |
denotes |
, |
T1261 |
4567-4576 |
VBG |
denotes |
resulting |
T1262 |
4577-4581 |
IN |
denotes |
from |
T1263 |
4582-4585 |
NN |
denotes |
RNA |
T1264 |
4586-4593 |
NN |
denotes |
editing |
T1265 |
4594-4596 |
IN |
denotes |
of |
T1266 |
4597-4601 |
NN |
denotes |
GluR |
T1267 |
4602-4603 |
NN |
denotes |
B |
T1268 |
4601-4602 |
HYPH |
denotes |
- |
T1269 |
4604-4612 |
NN |
denotes |
pre-mRNA |
T1270 |
4613-4614 |
-LRB- |
denotes |
( |
T1271 |
4615-4617 |
CD |
denotes |
49 |
T1272 |
4614-4615 |
-LRB- |
denotes |
[ |
T1273 |
4617-4618 |
-RRB- |
denotes |
] |
T1274 |
4618-4619 |
: |
denotes |
; |
T1275 |
4620-4628 |
VBN |
denotes |
reviewed |
T1276 |
4629-4631 |
IN |
denotes |
in |
T1277 |
4632-4633 |
-LRB- |
denotes |
[ |
T1278 |
4633-4635 |
CD |
denotes |
50 |
T1279 |
4635-4636 |
-RRB- |
denotes |
] |
T1280 |
4636-4637 |
-RRB- |
denotes |
) |
T1281 |
4637-4638 |
. |
denotes |
. |
T1282 |
4638-4886 |
sentence |
denotes |
Hence, either GluR-B deficiency, or the expression of Q/R site-unedited GluR-B with a glutamine residue at the critical channel site, leads to increased Ca2+ permeability of AMPA channels, as amply demonstrated in gene-targeted mice [51,53,58,60]. |
T1283 |
4639-4644 |
RB |
denotes |
Hence |
T1284 |
4773-4778 |
VBZ |
denotes |
leads |
T1285 |
4644-4646 |
, |
denotes |
, |
T1286 |
4646-4652 |
CC |
denotes |
either |
T1287 |
4660-4670 |
NN |
denotes |
deficiency |
T1288 |
4653-4657 |
NN |
denotes |
GluR |
T1289 |
4658-4659 |
NN |
denotes |
B |
T1290 |
4657-4658 |
HYPH |
denotes |
- |
T1291 |
4670-4672 |
, |
denotes |
, |
T1292 |
4672-4674 |
CC |
denotes |
or |
T1293 |
4675-4678 |
DT |
denotes |
the |
T1294 |
4679-4689 |
NN |
denotes |
expression |
T1295 |
4690-4692 |
IN |
denotes |
of |
T1296 |
4693-4694 |
NN |
denotes |
Q |
T1297 |
4695-4696 |
NN |
denotes |
R |
T1298 |
4694-4695 |
HYPH |
denotes |
/ |
T1299 |
4716-4717 |
NN |
denotes |
B |
T1300 |
4697-4701 |
NN |
denotes |
site |
T1301 |
4702-4710 |
JJ |
denotes |
unedited |
T1302 |
4701-4702 |
HYPH |
denotes |
- |
T1303 |
4711-4715 |
NN |
denotes |
GluR |
T1304 |
4715-4716 |
HYPH |
denotes |
- |
T1903 |
7838-7844 |
NN |
denotes |
memory |
T1305 |
4718-4722 |
IN |
denotes |
with |
T1306 |
4723-4724 |
DT |
denotes |
a |
T1307 |
4735-4742 |
NN |
denotes |
residue |
T1308 |
4725-4734 |
NN |
denotes |
glutamine |
T1309 |
4743-4745 |
IN |
denotes |
at |
T1310 |
4746-4749 |
DT |
denotes |
the |
T1311 |
4767-4771 |
NN |
denotes |
site |
T1312 |
4750-4758 |
JJ |
denotes |
critical |
T1313 |
4759-4766 |
NN |
denotes |
channel |
T1314 |
4771-4773 |
, |
denotes |
, |
T1315 |
4779-4781 |
IN |
denotes |
to |
T1316 |
4782-4791 |
VBN |
denotes |
increased |
T1317 |
4797-4809 |
NN |
denotes |
permeability |
T1318 |
4792-4795 |
NN |
denotes |
Ca2 |
T1319 |
4795-4796 |
SYM |
denotes |
+ |
T1320 |
4810-4812 |
IN |
denotes |
of |
T1321 |
4813-4817 |
NN |
denotes |
AMPA |
T1322 |
4818-4826 |
NNS |
denotes |
channels |
T1323 |
4826-4828 |
, |
denotes |
, |
T1324 |
4828-4830 |
IN |
denotes |
as |
T1325 |
4837-4849 |
VBN |
denotes |
demonstrated |
T1326 |
4831-4836 |
RB |
denotes |
amply |
T1327 |
4850-4852 |
IN |
denotes |
in |
T1328 |
4853-4857 |
NN |
denotes |
gene |
T1329 |
4858-4866 |
VBN |
denotes |
targeted |
T1330 |
4857-4858 |
HYPH |
denotes |
- |
T1331 |
4867-4871 |
NNS |
denotes |
mice |
T1332 |
4872-4873 |
-LRB- |
denotes |
[ |
T1333 |
4882-4884 |
CD |
denotes |
60 |
T1334 |
4873-4875 |
CD |
denotes |
51 |
T1335 |
4875-4876 |
, |
denotes |
, |
T1336 |
4876-4878 |
CD |
denotes |
53 |
T1337 |
4878-4879 |
, |
denotes |
, |
T1338 |
4879-4881 |
CD |
denotes |
58 |
T1339 |
4881-4882 |
, |
denotes |
, |
T1341 |
4885-4886 |
. |
denotes |
. |
T1342 |
4886-5020 |
sentence |
denotes |
Thus, the absence of GluR-B, or the expression of GluR-B(Q) in the olfactory bulb, may generate increased inhibition in mitral cells. |
T1343 |
4887-4891 |
RB |
denotes |
Thus |
T1344 |
4974-4982 |
VB |
denotes |
generate |
T1345 |
4891-4893 |
, |
denotes |
, |
T1346 |
4893-4896 |
DT |
denotes |
the |
T1347 |
4897-4904 |
NN |
denotes |
absence |
T1348 |
4905-4907 |
IN |
denotes |
of |
T1349 |
4908-4912 |
NN |
denotes |
GluR |
T1350 |
4913-4914 |
NN |
denotes |
B |
T1351 |
4912-4913 |
HYPH |
denotes |
- |
T1352 |
4914-4916 |
, |
denotes |
, |
T1353 |
4916-4918 |
CC |
denotes |
or |
T1354 |
4919-4922 |
DT |
denotes |
the |
T1355 |
4923-4933 |
NN |
denotes |
expression |
T1356 |
4934-4936 |
IN |
denotes |
of |
T1357 |
4937-4941 |
NN |
denotes |
GluR |
T1358 |
4944-4945 |
NN |
denotes |
Q |
T1359 |
4941-4942 |
HYPH |
denotes |
- |
T1360 |
4942-4943 |
NN |
denotes |
B |
T1361 |
4943-4944 |
-LRB- |
denotes |
( |
T1362 |
4945-4946 |
-RRB- |
denotes |
) |
T1363 |
4947-4949 |
IN |
denotes |
in |
T1364 |
4950-4953 |
DT |
denotes |
the |
T1365 |
4964-4968 |
NN |
denotes |
bulb |
T1366 |
4954-4963 |
JJ |
denotes |
olfactory |
T1367 |
4968-4970 |
, |
denotes |
, |
T1368 |
4970-4973 |
MD |
denotes |
may |
T1369 |
4983-4992 |
VBN |
denotes |
increased |
T1370 |
4993-5003 |
NN |
denotes |
inhibition |
T1371 |
5004-5006 |
IN |
denotes |
in |
T1372 |
5007-5013 |
JJ |
denotes |
mitral |
T1373 |
5014-5019 |
NNS |
denotes |
cells |
T1374 |
5019-5020 |
. |
denotes |
. |
T1375 |
5020-5343 |
sentence |
denotes |
Moreover, the ablation of GluR-B, but also changes in the extent of Q/R site editing of GluR-B, can alter the strength of excitatory synaptic transmission in the genetically addressed neuronal populations [51,58,60], thus potentially shifting the balance of excitatory and inhibitory transmission in the affected circuits. |
T1376 |
5021-5029 |
RB |
denotes |
Moreover |
T1377 |
5121-5126 |
VB |
denotes |
alter |
T1378 |
5029-5031 |
, |
denotes |
, |
T1379 |
5031-5034 |
DT |
denotes |
the |
T1380 |
5035-5043 |
NN |
denotes |
ablation |
T1381 |
5047-5051 |
NN |
denotes |
GluR |
T1382 |
5052-5053 |
NN |
denotes |
B |
T1383 |
5051-5052 |
HYPH |
denotes |
- |
T1384 |
5053-5055 |
, |
denotes |
, |
T1385 |
5055-5058 |
CC |
denotes |
but |
T1386 |
5059-5063 |
RB |
denotes |
also |
T1387 |
5064-5071 |
NNS |
denotes |
changes |
T1388 |
5072-5074 |
IN |
denotes |
in |
T1389 |
5075-5078 |
DT |
denotes |
the |
T1390 |
5079-5085 |
NN |
denotes |
extent |
T1391 |
5086-5088 |
IN |
denotes |
of |
T1392 |
5089-5090 |
NN |
denotes |
Q |
T1393 |
5091-5092 |
NN |
denotes |
R |
T1394 |
5090-5091 |
HYPH |
denotes |
/ |
T1395 |
5098-5105 |
NN |
denotes |
editing |
T1396 |
5093-5097 |
NN |
denotes |
site |
T1397 |
5106-5108 |
IN |
denotes |
of |
T1398 |
5109-5113 |
NN |
denotes |
GluR |
T1399 |
5114-5115 |
NN |
denotes |
B |
T1400 |
5113-5114 |
HYPH |
denotes |
- |
T1401 |
5115-5117 |
, |
denotes |
, |
T1402 |
5117-5120 |
MD |
denotes |
can |
T1403 |
5127-5130 |
DT |
denotes |
the |
T1404 |
5131-5139 |
NN |
denotes |
strength |
T1405 |
5140-5142 |
IN |
denotes |
of |
T1406 |
5143-5153 |
JJ |
denotes |
excitatory |
T1407 |
5163-5175 |
NN |
denotes |
transmission |
T1408 |
5154-5162 |
JJ |
denotes |
synaptic |
T1409 |
5176-5178 |
IN |
denotes |
in |
T1410 |
5179-5182 |
DT |
denotes |
the |
T1411 |
5214-5225 |
NNS |
denotes |
populations |
T1412 |
5183-5194 |
RB |
denotes |
genetically |
T1413 |
5195-5204 |
VBN |
denotes |
addressed |
T1414 |
5205-5213 |
JJ |
denotes |
neuronal |
T1415 |
5226-5227 |
-LRB- |
denotes |
[ |
T1416 |
5233-5235 |
CD |
denotes |
60 |
T1417 |
5227-5229 |
CD |
denotes |
51 |
T1418 |
5229-5230 |
, |
denotes |
, |
T1419 |
5230-5232 |
CD |
denotes |
58 |
T1420 |
5232-5233 |
, |
denotes |
, |
T1421 |
5235-5236 |
-RRB- |
denotes |
] |
T1422 |
5236-5238 |
, |
denotes |
, |
T1423 |
5238-5242 |
RB |
denotes |
thus |
T1424 |
5255-5263 |
VBG |
denotes |
shifting |
T1425 |
5243-5254 |
RB |
denotes |
potentially |
T1426 |
5264-5267 |
DT |
denotes |
the |
T1427 |
5268-5275 |
NN |
denotes |
balance |
T1428 |
5276-5278 |
IN |
denotes |
of |
T1429 |
5279-5289 |
JJ |
denotes |
excitatory |
T1430 |
5305-5317 |
NN |
denotes |
transmission |
T1431 |
5290-5293 |
CC |
denotes |
and |
T1432 |
5294-5304 |
JJ |
denotes |
inhibitory |
T1433 |
5318-5320 |
IN |
denotes |
in |
T1434 |
5321-5324 |
DT |
denotes |
the |
T1435 |
5334-5342 |
NNS |
denotes |
circuits |
T1436 |
5325-5333 |
VBN |
denotes |
affected |
T1437 |
5342-5343 |
. |
denotes |
. |
T1438 |
5343-5493 |
sentence |
denotes |
Similarly, changes in synaptic plasticity due to Ca2+-permeable AMPARs [51,52,60], e.g., in piriform cortex, might alter odor memorization processes. |
T1439 |
5344-5353 |
RB |
denotes |
Similarly |
T1440 |
5459-5464 |
VB |
denotes |
alter |
T1441 |
5353-5355 |
, |
denotes |
, |
T1442 |
5355-5362 |
NNS |
denotes |
changes |
T1443 |
5363-5365 |
IN |
denotes |
in |
T1444 |
5375-5385 |
NN |
denotes |
plasticity |
T1445 |
5386-5389 |
IN |
denotes |
due |
T1446 |
5390-5392 |
IN |
denotes |
to |
T1447 |
5393-5396 |
NN |
denotes |
Ca2 |
T1448 |
5398-5407 |
JJ |
denotes |
permeable |
T1449 |
5396-5397 |
SYM |
denotes |
+ |
T1450 |
5397-5398 |
HYPH |
denotes |
- |
T1451 |
5408-5414 |
NNS |
denotes |
AMPARs |
T1452 |
5415-5416 |
-LRB- |
denotes |
[ |
T1453 |
5422-5424 |
CD |
denotes |
60 |
T1454 |
5416-5418 |
CD |
denotes |
51 |
T1455 |
5418-5419 |
, |
denotes |
, |
T1456 |
5419-5421 |
CD |
denotes |
52 |
T1457 |
5421-5422 |
, |
denotes |
, |
T1458 |
5424-5425 |
-RRB- |
denotes |
] |
T1459 |
5425-5427 |
, |
denotes |
, |
T1460 |
5427-5431 |
FW |
denotes |
e.g. |
T1461 |
5433-5435 |
IN |
denotes |
in |
T1462 |
5431-5433 |
, |
denotes |
, |
T1463 |
5436-5444 |
JJ |
denotes |
piriform |
T1464 |
5445-5451 |
NN |
denotes |
cortex |
T1465 |
5451-5453 |
, |
denotes |
, |
T1466 |
5453-5458 |
MD |
denotes |
might |
T1467 |
5465-5469 |
NN |
denotes |
odor |
T1468 |
5470-5482 |
NN |
denotes |
memorization |
T1469 |
5483-5492 |
NNS |
denotes |
processes |
T1470 |
5492-5493 |
. |
denotes |
. |
T1471 |
5493-5653 |
sentence |
denotes |
Thus, alterations of AMPAR properties in these brain regions will allow investigation and possibly separation of mechanisms underlying these behavioral traits. |
T1472 |
5494-5498 |
RB |
denotes |
Thus |
T1473 |
5560-5565 |
VB |
denotes |
allow |
T1474 |
5498-5500 |
, |
denotes |
, |
T1475 |
5500-5511 |
NNS |
denotes |
alterations |
T1476 |
5512-5514 |
IN |
denotes |
of |
T1477 |
5515-5520 |
NN |
denotes |
AMPAR |
T1478 |
5521-5531 |
NNS |
denotes |
properties |
T1486 |
5584-5592 |
RB |
denotes |
possibly |
T1509 |
5724-5728 |
NN |
denotes |
GluR |
T1479 |
5532-5534 |
IN |
denotes |
in |
T1480 |
5535-5540 |
DT |
denotes |
these |
T1481 |
5547-5554 |
NNS |
denotes |
regions |
T1482 |
5541-5546 |
NN |
denotes |
brain |
T1483 |
5555-5559 |
MD |
denotes |
will |
T1484 |
5566-5579 |
NN |
denotes |
investigation |
T1485 |
5580-5583 |
CC |
denotes |
and |
T1487 |
5593-5603 |
NN |
denotes |
separation |
T1488 |
5604-5606 |
IN |
denotes |
of |
T1489 |
5607-5617 |
NNS |
denotes |
mechanisms |
T1490 |
5618-5628 |
VBG |
denotes |
underlying |
T1491 |
5629-5634 |
DT |
denotes |
these |
T1492 |
5646-5652 |
NNS |
denotes |
traits |
T1493 |
5635-5645 |
JJ |
denotes |
behavioral |
T1494 |
5652-5653 |
. |
denotes |
. |
T1495 |
5653-5919 |
sentence |
denotes |
Concerning this intended switch in AMPAR properties, mice lacking all GluR-B, however, show a widespread impairment in behavior, including lethargy, motor coordination problems, and deficits in exploratory activity [51], which preclude detailed behavioral analyses. |
T1496 |
5654-5664 |
VBG |
denotes |
Concerning |
T1497 |
5741-5745 |
VBP |
denotes |
show |
T1498 |
5665-5669 |
DT |
denotes |
this |
T1499 |
5679-5685 |
NN |
denotes |
switch |
T1500 |
5670-5678 |
VBN |
denotes |
intended |
T1501 |
5686-5688 |
IN |
denotes |
in |
T1502 |
5689-5694 |
NN |
denotes |
AMPAR |
T1503 |
5695-5705 |
NNS |
denotes |
properties |
T1504 |
5705-5707 |
, |
denotes |
, |
T1505 |
5707-5711 |
NNS |
denotes |
mice |
T1506 |
5712-5719 |
VBG |
denotes |
lacking |
T1507 |
5720-5723 |
DT |
denotes |
all |
T1508 |
5729-5730 |
NN |
denotes |
B |
T1510 |
5728-5729 |
HYPH |
denotes |
- |
T1511 |
5730-5732 |
, |
denotes |
, |
T1512 |
5732-5739 |
RB |
denotes |
however |
T1513 |
5739-5741 |
, |
denotes |
, |
T1514 |
5746-5747 |
DT |
denotes |
a |
T1515 |
5759-5769 |
NN |
denotes |
impairment |
T1516 |
5748-5758 |
JJ |
denotes |
widespread |
T1517 |
5770-5772 |
IN |
denotes |
in |
T1518 |
5773-5781 |
NN |
denotes |
behavior |
T1519 |
5781-5783 |
, |
denotes |
, |
T1520 |
5783-5792 |
VBG |
denotes |
including |
T1521 |
5793-5801 |
NN |
denotes |
lethargy |
T1522 |
5801-5803 |
, |
denotes |
, |
T1523 |
5803-5808 |
NN |
denotes |
motor |
T1524 |
5809-5821 |
NN |
denotes |
coordination |
T1525 |
5822-5830 |
NNS |
denotes |
problems |
T1526 |
5830-5832 |
, |
denotes |
, |
T1527 |
5832-5835 |
CC |
denotes |
and |
T1528 |
5836-5844 |
NNS |
denotes |
deficits |
T1529 |
5845-5847 |
IN |
denotes |
in |
T1530 |
5848-5859 |
JJ |
denotes |
exploratory |
T1531 |
5860-5868 |
NN |
denotes |
activity |
T1532 |
5869-5870 |
-LRB- |
denotes |
[ |
T1533 |
5870-5872 |
CD |
denotes |
51 |
T1534 |
5872-5873 |
-RRB- |
denotes |
] |
T1535 |
5873-5875 |
, |
denotes |
, |
T1536 |
5875-5880 |
WDT |
denotes |
which |
T1537 |
5881-5889 |
VBP |
denotes |
preclude |
T1538 |
5890-5898 |
JJ |
denotes |
detailed |
T1539 |
5910-5918 |
NNS |
denotes |
analyses |
T1540 |
5899-5909 |
JJ |
denotes |
behavioral |
T1541 |
5918-5919 |
. |
denotes |
. |
T1542 |
5919-6089 |
sentence |
denotes |
Similarly, mice expressing (in the entire brain) a substantial part of the GluR-B population in the Q/R site-unedited form become seizure-prone and die prematurely [53]. |
T1543 |
5920-5929 |
RB |
denotes |
Similarly |
T1544 |
6043-6049 |
VBP |
denotes |
become |
T1545 |
5929-5931 |
, |
denotes |
, |
T1546 |
5931-5935 |
NNS |
denotes |
mice |
T1547 |
5936-5946 |
VBG |
denotes |
expressing |
T1548 |
5947-5948 |
-LRB- |
denotes |
( |
T1549 |
5948-5950 |
IN |
denotes |
in |
T1550 |
5951-5954 |
DT |
denotes |
the |
T1551 |
5962-5967 |
NN |
denotes |
brain |
T1552 |
5955-5961 |
JJ |
denotes |
entire |
T1553 |
5967-5968 |
-RRB- |
denotes |
) |
T1554 |
5969-5970 |
DT |
denotes |
a |
T1555 |
5983-5987 |
NN |
denotes |
part |
T1556 |
5971-5982 |
JJ |
denotes |
substantial |
T1557 |
5988-5990 |
IN |
denotes |
of |
T1558 |
5991-5994 |
DT |
denotes |
the |
T1559 |
6002-6012 |
NN |
denotes |
population |
T1560 |
5995-5999 |
NN |
denotes |
GluR |
T1561 |
6000-6001 |
NN |
denotes |
B |
T1562 |
5999-6000 |
HYPH |
denotes |
- |
T1563 |
6013-6015 |
IN |
denotes |
in |
T1564 |
6016-6019 |
DT |
denotes |
the |
T1565 |
6038-6042 |
NN |
denotes |
form |
T1566 |
6020-6021 |
NN |
denotes |
Q |
T1567 |
6022-6023 |
NN |
denotes |
R |
T1568 |
6021-6022 |
HYPH |
denotes |
/ |
T1569 |
6024-6028 |
NN |
denotes |
site |
T1570 |
6029-6037 |
JJ |
denotes |
unedited |
T1571 |
6028-6029 |
HYPH |
denotes |
- |
T1572 |
6050-6057 |
NN |
denotes |
seizure |
T1573 |
6058-6063 |
JJ |
denotes |
prone |
T1574 |
6057-6058 |
HYPH |
denotes |
- |
T1575 |
6064-6067 |
CC |
denotes |
and |
T1576 |
6068-6071 |
VBP |
denotes |
die |
T1577 |
6072-6083 |
RB |
denotes |
prematurely |
T1578 |
6084-6085 |
-LRB- |
denotes |
[ |
T1579 |
6085-6087 |
CD |
denotes |
53 |
T1580 |
6087-6088 |
-RRB- |
denotes |
] |
T1581 |
6088-6089 |
. |
denotes |
. |
T1582 |
6089-6408 |
sentence |
denotes |
Some of these problems can be partially overcome by use of spatially and temporally restricted expression systems [54–56], in particular the Cre-lox system, with Cre-recombinase expression in defined brain areas of gene-targeted mice carrying GluR-B alleles marked by loxP sites for Cre-mediated recombination [55,57]. |
T1583 |
6090-6094 |
DT |
denotes |
Some |
T1584 |
6130-6138 |
VBN |
denotes |
overcome |
T1585 |
6095-6097 |
IN |
denotes |
of |
T1586 |
6098-6103 |
DT |
denotes |
these |
T1587 |
6104-6112 |
NNS |
denotes |
problems |
T1588 |
6113-6116 |
MD |
denotes |
can |
T1589 |
6117-6119 |
VB |
denotes |
be |
T1590 |
6120-6129 |
RB |
denotes |
partially |
T1591 |
6139-6141 |
IN |
denotes |
by |
T1592 |
6142-6145 |
NN |
denotes |
use |
T1593 |
6146-6148 |
IN |
denotes |
of |
T1594 |
6149-6158 |
RB |
denotes |
spatially |
T1595 |
6174-6184 |
VBN |
denotes |
restricted |
T1596 |
6159-6162 |
CC |
denotes |
and |
T1597 |
6163-6173 |
RB |
denotes |
temporally |
T1598 |
6196-6203 |
NNS |
denotes |
systems |
T1599 |
6185-6195 |
NN |
denotes |
expression |
T1600 |
6204-6205 |
-LRB- |
denotes |
[ |
T1601 |
6205-6207 |
CD |
denotes |
54 |
T1602 |
6207-6208 |
SYM |
denotes |
– |
T1603 |
6208-6210 |
CD |
denotes |
56 |
T1604 |
6210-6211 |
-RRB- |
denotes |
] |
T1605 |
6211-6213 |
, |
denotes |
, |
T1606 |
6213-6215 |
IN |
denotes |
in |
T1607 |
6239-6245 |
NN |
denotes |
system |
T1608 |
6216-6226 |
JJ |
denotes |
particular |
T1609 |
6227-6230 |
DT |
denotes |
the |
T1610 |
6231-6234 |
NN |
denotes |
Cre |
T1611 |
6235-6238 |
NN |
denotes |
lox |
T1612 |
6234-6235 |
HYPH |
denotes |
- |
T1613 |
6245-6247 |
, |
denotes |
, |
T1614 |
6247-6251 |
IN |
denotes |
with |
T1615 |
6348-6354 |
VBN |
denotes |
marked |
T1616 |
6252-6255 |
NN |
denotes |
Cre |
T1617 |
6256-6267 |
NN |
denotes |
recombinase |
T1618 |
6255-6256 |
HYPH |
denotes |
- |
T1619 |
6268-6278 |
NN |
denotes |
expression |
T1620 |
6279-6281 |
IN |
denotes |
in |
T1621 |
6282-6289 |
VBN |
denotes |
defined |
T1622 |
6296-6301 |
NNS |
denotes |
areas |
T1623 |
6290-6295 |
NN |
denotes |
brain |
T1624 |
6302-6304 |
IN |
denotes |
of |
T1625 |
6305-6309 |
NN |
denotes |
gene |
T1626 |
6310-6318 |
VBN |
denotes |
targeted |
T1627 |
6309-6310 |
HYPH |
denotes |
- |
T1628 |
6319-6323 |
NNS |
denotes |
mice |
T1629 |
6324-6332 |
VBG |
denotes |
carrying |
T1630 |
6333-6337 |
NN |
denotes |
GluR |
T1631 |
6338-6339 |
NN |
denotes |
B |
T1632 |
6337-6338 |
HYPH |
denotes |
- |
T1633 |
6340-6347 |
NNS |
denotes |
alleles |
T1634 |
6355-6357 |
IN |
denotes |
by |
T1635 |
6358-6362 |
NN |
denotes |
loxP |
T1636 |
6363-6368 |
NNS |
denotes |
sites |
T1637 |
6369-6372 |
IN |
denotes |
for |
T1638 |
6373-6376 |
NN |
denotes |
Cre |
T1639 |
6377-6385 |
VBN |
denotes |
mediated |
T1640 |
6376-6377 |
HYPH |
denotes |
- |
T1641 |
6386-6399 |
NN |
denotes |
recombination |
T1642 |
6400-6401 |
-LRB- |
denotes |
[ |
T1643 |
6404-6406 |
CD |
denotes |
57 |
T1644 |
6403-6404 |
, |
denotes |
, |
T1645 |
6406-6407 |
-RRB- |
denotes |
] |
T1646 |
6407-6408 |
. |
denotes |
. |
T1647 |
6408-6568 |
sentence |
denotes |
Indeed, restricting the expression of Q/R site-unedited GluR-B to forebrain resulted in almost normal lifespan and an only weakly seizure-prone phenotype [58]. |
T1648 |
6409-6415 |
RB |
denotes |
Indeed |
T1649 |
6485-6493 |
VBD |
denotes |
resulted |
T1650 |
6415-6417 |
, |
denotes |
, |
T1651 |
6417-6428 |
VBG |
denotes |
restricting |
T1652 |
6429-6432 |
DT |
denotes |
the |
T1653 |
6433-6443 |
NN |
denotes |
expression |
T1654 |
6444-6446 |
IN |
denotes |
of |
T1655 |
6447-6448 |
NN |
denotes |
Q |
T1656 |
6449-6450 |
NN |
denotes |
R |
T1657 |
6448-6449 |
HYPH |
denotes |
/ |
T1658 |
6470-6471 |
NN |
denotes |
B |
T1659 |
6451-6455 |
NN |
denotes |
site |
T1660 |
6456-6464 |
JJ |
denotes |
unedited |
T1661 |
6455-6456 |
HYPH |
denotes |
- |
T1662 |
6465-6469 |
NN |
denotes |
GluR |
T1663 |
6469-6470 |
HYPH |
denotes |
- |
T1684 |
6615-6623 |
VBD |
denotes |
appeared |
T1664 |
6472-6474 |
IN |
denotes |
to |
T1665 |
6475-6484 |
NN |
denotes |
forebrain |
T1666 |
6494-6496 |
IN |
denotes |
in |
T1667 |
6497-6503 |
RB |
denotes |
almost |
T1668 |
6504-6510 |
JJ |
denotes |
normal |
T1669 |
6511-6519 |
NN |
denotes |
lifespan |
T1670 |
6520-6523 |
CC |
denotes |
and |
T1671 |
6524-6526 |
DT |
denotes |
an |
T1672 |
6553-6562 |
NN |
denotes |
phenotype |
T1673 |
6527-6531 |
RB |
denotes |
only |
T1674 |
6532-6538 |
RB |
denotes |
weakly |
T1675 |
6547-6552 |
JJ |
denotes |
prone |
T1676 |
6539-6546 |
NN |
denotes |
seizure |
T1677 |
6546-6547 |
HYPH |
denotes |
- |
T1678 |
6563-6564 |
-LRB- |
denotes |
[ |
T1679 |
6564-6566 |
CD |
denotes |
58 |
T1680 |
6566-6567 |
-RRB- |
denotes |
] |
T1681 |
6567-6568 |
. |
denotes |
. |
T1682 |
6568-6779 |
sentence |
denotes |
Mice with forebrain-specific GluR-B depletion appeared almost completely normal throughout life with no developmental abnormalities, thus permitting a detailed, quantitative investigation of olfactory behavior. |
T1683 |
6569-6573 |
NNS |
denotes |
Mice |
T1685 |
6574-6578 |
IN |
denotes |
with |
T1686 |
6579-6588 |
NN |
denotes |
forebrain |
T1687 |
6589-6597 |
JJ |
denotes |
specific |
T1688 |
6588-6589 |
HYPH |
denotes |
- |
T1689 |
6605-6614 |
NN |
denotes |
depletion |
T1690 |
6598-6602 |
NN |
denotes |
GluR |
T1691 |
6603-6604 |
NN |
denotes |
B |
T1692 |
6602-6603 |
HYPH |
denotes |
- |
T1693 |
6624-6630 |
RB |
denotes |
almost |
T1694 |
6631-6641 |
RB |
denotes |
completely |
T1695 |
6642-6648 |
JJ |
denotes |
normal |
T1696 |
6649-6659 |
IN |
denotes |
throughout |
T1697 |
6660-6664 |
NN |
denotes |
life |
T1698 |
6665-6669 |
IN |
denotes |
with |
T1699 |
6670-6672 |
DT |
denotes |
no |
T1700 |
6687-6700 |
NNS |
denotes |
abnormalities |
T1701 |
6673-6686 |
JJ |
denotes |
developmental |
T1702 |
6700-6702 |
, |
denotes |
, |
T1703 |
6702-6706 |
RB |
denotes |
thus |
T1704 |
6707-6717 |
VBG |
denotes |
permitting |
T1705 |
6718-6719 |
DT |
denotes |
a |
T1706 |
6743-6756 |
NN |
denotes |
investigation |
T1707 |
6720-6728 |
VBN |
denotes |
detailed |
T1708 |
6728-6730 |
, |
denotes |
, |
T1709 |
6730-6742 |
JJ |
denotes |
quantitative |
T1710 |
6757-6759 |
IN |
denotes |
of |
T1711 |
6760-6769 |
JJ |
denotes |
olfactory |
T1712 |
6770-6778 |
NN |
denotes |
behavior |
T1713 |
6778-6779 |
. |
denotes |
. |
T1714 |
6779-7058 |
sentence |
denotes |
To allow for the mechanistic separation of olfactory learning, discrimination, and memory, we exploited a well-known phenomenon of transgenes, which concerns heterogeneous expression among different founder lines and even among genetically identical individuals of a given line. |
T1715 |
6780-6782 |
TO |
denotes |
To |
T1716 |
6783-6788 |
VB |
denotes |
allow |
T1717 |
6874-6883 |
VBD |
denotes |
exploited |
T1718 |
6789-6792 |
IN |
denotes |
for |
T1719 |
6793-6796 |
DT |
denotes |
the |
T1720 |
6809-6819 |
NN |
denotes |
separation |
T1721 |
6797-6808 |
JJ |
denotes |
mechanistic |
T1722 |
6820-6822 |
IN |
denotes |
of |
T1723 |
6823-6832 |
JJ |
denotes |
olfactory |
T1724 |
6833-6841 |
NN |
denotes |
learning |
T1725 |
6841-6843 |
, |
denotes |
, |
T1726 |
6843-6857 |
NN |
denotes |
discrimination |
T1727 |
6857-6859 |
, |
denotes |
, |
T1728 |
6859-6862 |
CC |
denotes |
and |
T1729 |
6863-6869 |
NN |
denotes |
memory |
T1730 |
6871-6873 |
PRP |
denotes |
we |
T1731 |
6884-6885 |
DT |
denotes |
a |
T1732 |
6897-6907 |
NN |
denotes |
phenomenon |
T1733 |
6886-6890 |
RB |
denotes |
well |
T1734 |
6891-6896 |
VBN |
denotes |
known |
T1735 |
6890-6891 |
HYPH |
denotes |
- |
T1736 |
6908-6910 |
IN |
denotes |
of |
T1737 |
6911-6921 |
NNS |
denotes |
transgenes |
T1738 |
6921-6923 |
, |
denotes |
, |
T1739 |
6923-6928 |
WDT |
denotes |
which |
T1740 |
6929-6937 |
VBZ |
denotes |
concerns |
T1741 |
6938-6951 |
JJ |
denotes |
heterogeneous |
T1742 |
6952-6962 |
NN |
denotes |
expression |
T1743 |
6963-6968 |
IN |
denotes |
among |
T1744 |
6969-6978 |
JJ |
denotes |
different |
T1745 |
6987-6992 |
NNS |
denotes |
lines |
T1746 |
6979-6986 |
NN |
denotes |
founder |
T1747 |
6993-6996 |
CC |
denotes |
and |
T1748 |
6997-7001 |
RB |
denotes |
even |
T1749 |
7002-7007 |
IN |
denotes |
among |
T1750 |
7008-7019 |
RB |
denotes |
genetically |
T1751 |
7020-7029 |
JJ |
denotes |
identical |
T1752 |
7030-7041 |
NNS |
denotes |
individuals |
T1753 |
7042-7044 |
IN |
denotes |
of |
T1754 |
7045-7046 |
DT |
denotes |
a |
T1755 |
7053-7057 |
NN |
denotes |
line |
T1756 |
7047-7052 |
JJ |
denotes |
given |
T1757 |
7057-7058 |
. |
denotes |
. |
T1758 |
7058-7289 |
sentence |
denotes |
Although such “mosaic” expression is usually undesired, here we took advantage of it by ablating GluR-B via gene-targeted, floxed GluR-B alleles with the help of a transgenic mouse line with variegated Cre expression in forebrain. |
T1759 |
7059-7067 |
IN |
denotes |
Although |
T1760 |
7093-7095 |
VBZ |
denotes |
is |
T1761 |
7068-7072 |
JJ |
denotes |
such |
T1762 |
7082-7092 |
NN |
denotes |
expression |
T1763 |
7073-7074 |
`` |
denotes |
“ |
T1764 |
7074-7080 |
NN |
denotes |
mosaic |
T1765 |
7080-7081 |
'' |
denotes |
” |
T1766 |
7123-7127 |
VBD |
denotes |
took |
T1767 |
7096-7103 |
RB |
denotes |
usually |
T1768 |
7104-7113 |
JJ |
denotes |
undesired |
T1769 |
7113-7115 |
, |
denotes |
, |
T1770 |
7115-7119 |
RB |
denotes |
here |
T1771 |
7120-7122 |
PRP |
denotes |
we |
T1772 |
7128-7137 |
NN |
denotes |
advantage |
T1773 |
7138-7140 |
IN |
denotes |
of |
T1774 |
7141-7143 |
PRP |
denotes |
it |
T1775 |
7144-7146 |
IN |
denotes |
by |
T1776 |
7147-7155 |
VBG |
denotes |
ablating |
T1777 |
7156-7160 |
NN |
denotes |
GluR |
T1778 |
7161-7162 |
NN |
denotes |
B |
T1779 |
7160-7161 |
HYPH |
denotes |
- |
T1780 |
7163-7166 |
IN |
denotes |
via |
T1781 |
7167-7171 |
NN |
denotes |
gene |
T1782 |
7172-7180 |
VBN |
denotes |
targeted |
T1783 |
7171-7172 |
HYPH |
denotes |
- |
T1784 |
7196-7203 |
NNS |
denotes |
alleles |
T1785 |
7180-7182 |
, |
denotes |
, |
T1786 |
7182-7188 |
VBN |
denotes |
floxed |
T1787 |
7189-7193 |
NN |
denotes |
GluR |
T1788 |
7194-7195 |
NN |
denotes |
B |
T1789 |
7193-7194 |
HYPH |
denotes |
- |
T1790 |
7204-7208 |
IN |
denotes |
with |
T1791 |
7209-7212 |
DT |
denotes |
the |
T1792 |
7213-7217 |
NN |
denotes |
help |
T1793 |
7218-7220 |
IN |
denotes |
of |
T1794 |
7221-7222 |
DT |
denotes |
a |
T1795 |
7240-7244 |
NN |
denotes |
line |
T1796 |
7223-7233 |
JJ |
denotes |
transgenic |
T1797 |
7234-7239 |
NN |
denotes |
mouse |
T1798 |
7245-7249 |
IN |
denotes |
with |
T1799 |
7250-7260 |
VBN |
denotes |
variegated |
T1800 |
7265-7275 |
NN |
denotes |
expression |
T1801 |
7261-7264 |
NN |
denotes |
Cre |
T1802 |
7276-7278 |
IN |
denotes |
in |
T1803 |
7279-7288 |
NN |
denotes |
forebrain |
T1804 |
7288-7289 |
. |
denotes |
. |
T1805 |
7289-7469 |
sentence |
denotes |
By correlating GluR-B levels in olfaction-related brain regions with quantitative behavioral data, we investigated the dependence on GluR-B of olfactory discrimination and memory. |
T1806 |
7290-7292 |
IN |
denotes |
By |
T1807 |
7392-7404 |
VBD |
denotes |
investigated |
T1808 |
7293-7304 |
VBG |
denotes |
correlating |
T1809 |
7305-7309 |
NN |
denotes |
GluR |
T1810 |
7310-7311 |
NN |
denotes |
B |
T1811 |
7309-7310 |
HYPH |
denotes |
- |
T1812 |
7312-7318 |
NNS |
denotes |
levels |
T1813 |
7319-7321 |
IN |
denotes |
in |
T1814 |
7322-7331 |
NN |
denotes |
olfaction |
T1815 |
7332-7339 |
VBN |
denotes |
related |
T1816 |
7331-7332 |
HYPH |
denotes |
- |
T1817 |
7346-7353 |
NNS |
denotes |
regions |
T1885 |
7741-7745 |
NN |
denotes |
GluR |
T1818 |
7340-7345 |
NN |
denotes |
brain |
T1891 |
7757-7762 |
NN |
denotes |
AMPAR |
T1819 |
7354-7358 |
IN |
denotes |
with |
T1820 |
7359-7371 |
JJ |
denotes |
quantitative |
T1821 |
7383-7387 |
NNS |
denotes |
data |
T1822 |
7372-7382 |
JJ |
denotes |
behavioral |
T1823 |
7387-7389 |
, |
denotes |
, |
T1824 |
7389-7391 |
PRP |
denotes |
we |
T1825 |
7405-7408 |
DT |
denotes |
the |
T1826 |
7409-7419 |
NN |
denotes |
dependence |
T1827 |
7420-7422 |
IN |
denotes |
on |
T1828 |
7423-7427 |
NN |
denotes |
GluR |
T1829 |
7428-7429 |
NN |
denotes |
B |
T1830 |
7427-7428 |
HYPH |
denotes |
- |
T1831 |
7430-7432 |
IN |
denotes |
of |
T1832 |
7433-7442 |
JJ |
denotes |
olfactory |
T1833 |
7443-7457 |
NN |
denotes |
discrimination |
T1834 |
7458-7461 |
CC |
denotes |
and |
T1835 |
7462-7468 |
NN |
denotes |
memory |
T1836 |
7468-7469 |
. |
denotes |
. |
T1837 |
7469-7655 |
sentence |
denotes |
Moreover, to delineate the brain areas involved in these distinctive olfactory processes we used transgenic “rescue” of GluR-B ablation, specifically in piriform cortex and hippocampus. |
T1838 |
7470-7478 |
RB |
denotes |
Moreover |
T1839 |
7562-7566 |
VBD |
denotes |
used |
T1840 |
7478-7480 |
, |
denotes |
, |
T1841 |
7480-7482 |
TO |
denotes |
to |
T1842 |
7483-7492 |
VB |
denotes |
delineate |
T1843 |
7493-7496 |
DT |
denotes |
the |
T1844 |
7503-7508 |
NNS |
denotes |
areas |
T1845 |
7497-7502 |
NN |
denotes |
brain |
T1846 |
7509-7517 |
VBN |
denotes |
involved |
T1847 |
7518-7520 |
IN |
denotes |
in |
T1848 |
7521-7526 |
DT |
denotes |
these |
T1849 |
7549-7558 |
NNS |
denotes |
processes |
T1850 |
7527-7538 |
JJ |
denotes |
distinctive |
T1851 |
7539-7548 |
JJ |
denotes |
olfactory |
T1852 |
7559-7561 |
PRP |
denotes |
we |
T1853 |
7567-7577 |
JJ |
denotes |
transgenic |
T1854 |
7579-7585 |
NN |
denotes |
rescue |
T1855 |
7585-7586 |
'' |
denotes |
” |
T1856 |
7587-7589 |
IN |
denotes |
of |
T1857 |
7590-7594 |
NN |
denotes |
GluR |
T1858 |
7595-7596 |
NN |
denotes |
B |
T1859 |
7594-7595 |
HYPH |
denotes |
- |
T1860 |
7597-7605 |
NN |
denotes |
ablation |
T1861 |
7605-7607 |
, |
denotes |
, |
T1862 |
7607-7619 |
RB |
denotes |
specifically |
T1863 |
7620-7622 |
IN |
denotes |
in |
T1864 |
7623-7631 |
JJ |
denotes |
piriform |
T1865 |
7632-7638 |
NN |
denotes |
cortex |
T1866 |
7639-7642 |
CC |
denotes |
and |
T1867 |
7643-7654 |
NN |
denotes |
hippocampus |
T1868 |
7654-7655 |
. |
denotes |
. |
T1869 |
7655-7845 |
sentence |
denotes |
These efforts allowed us to dissect, both spatially and mechanistically, the role of GluR-B-mediated AMPAR properties in selected brain regions in odor learning, discrimination, and memory. |
T1870 |
7656-7661 |
DT |
denotes |
These |
T1871 |
7662-7669 |
NNS |
denotes |
efforts |
T1872 |
7670-7677 |
VBD |
denotes |
allowed |
T1873 |
7678-7680 |
PRP |
denotes |
us |
T1874 |
7684-7691 |
VB |
denotes |
dissect |
T1875 |
7681-7683 |
TO |
denotes |
to |
T1876 |
7691-7693 |
, |
denotes |
, |
T1877 |
7693-7697 |
DT |
denotes |
both |
T1878 |
7698-7707 |
RB |
denotes |
spatially |
T1879 |
7708-7711 |
CC |
denotes |
and |
T1880 |
7712-7727 |
RB |
denotes |
mechanistically |
T1881 |
7727-7729 |
, |
denotes |
, |
T1882 |
7729-7732 |
DT |
denotes |
the |
T1883 |
7733-7737 |
NN |
denotes |
role |
T1884 |
7738-7740 |
IN |
denotes |
of |
T1886 |
7746-7747 |
NN |
denotes |
B |
T1887 |
7745-7746 |
HYPH |
denotes |
- |
T1888 |
7748-7756 |
VBN |
denotes |
mediated |
T1889 |
7747-7748 |
HYPH |
denotes |
- |
T1890 |
7763-7773 |
NNS |
denotes |
properties |
T1892 |
7774-7776 |
IN |
denotes |
in |
T1893 |
7777-7785 |
VBN |
denotes |
selected |
T1894 |
7792-7799 |
NNS |
denotes |
regions |
T1895 |
7786-7791 |
NN |
denotes |
brain |
T1896 |
7800-7802 |
IN |
denotes |
in |
T1897 |
7803-7807 |
NN |
denotes |
odor |
T1898 |
7808-7816 |
NN |
denotes |
learning |
T1899 |
7816-7818 |
, |
denotes |
, |
T1900 |
7818-7832 |
NN |
denotes |
discrimination |
T1901 |
7832-7834 |
, |
denotes |
, |
T1904 |
7844-7845 |
. |
denotes |
. |
R5 |
T78 |
T73 |
conj |
Memory,Discrimination |
R6 |
T79 |
T78 |
amod |
Olfactory,Memory |
R18 |
T94 |
T96 |
nmod |
amino,isoxazolepropionate |
R19 |
T95 |
T94 |
punct |
-,amino |
R20 |
T96 |
T108 |
compound |
isoxazolepropionate,receptors |
R21 |
T97 |
T96 |
punct |
-,isoxazolepropionate |
R22 |
T98 |
T99 |
nummod |
3,hydroxy |
R24 |
T100 |
T99 |
punct |
-,hydroxy |
R25 |
T101 |
T96 |
punct |
-,isoxazolepropionate |
R26 |
T102 |
T103 |
nummod |
5,methyl |
R28 |
T104 |
T103 |
punct |
-,methyl |
R29 |
T105 |
T96 |
punct |
-,isoxazolepropionate |
R30 |
T106 |
T96 |
nummod |
4,isoxazolepropionate |
R31 |
T107 |
T96 |
punct |
-,isoxazolepropionate |
R61 |
T139 |
T137 |
punct |
+,Ca2 |
R62 |
T140 |
T138 |
punct |
-,permeable |
R75 |
T155 |
T153 |
pobj |
subunit,of |
R76 |
T156 |
T157 |
compound |
GluR,B |
R78 |
T158 |
T157 |
punct |
-,B |
R83 |
T163 |
T161 |
pobj |
Q,of |
R84 |
T164 |
T163 |
nmod |
GluR,Q |
R85 |
T165 |
T163 |
punct |
-,Q |
R86 |
T166 |
T163 |
nmod |
B,Q |
R87 |
T167 |
T163 |
punct |
(,Q |
R94 |
T174 |
T172 |
pobj |
permeability,to |
R95 |
T175 |
T174 |
nmod |
Ca2,permeability |
R96 |
T176 |
T175 |
punct |
+,Ca2 |
R103 |
T185 |
T183 |
pobj |
switch,with |
R104 |
T186 |
T185 |
amod |
functional,switch |
R105 |
T187 |
T185 |
compound |
AMPAR,switch |
R112 |
T194 |
T182 |
dobj |
discrimination,showed |
R113 |
T195 |
T194 |
amod |
olfactory,discrimination |
R120 |
T202 |
T200 |
pobj |
task,in |
R121 |
T203 |
T202 |
nmod |
go,task |
R122 |
T204 |
T203 |
punct |
/,go |
R123 |
T205 |
T206 |
det |
no,go |
R125 |
T207 |
T206 |
punct |
-,go |
R126 |
T208 |
T202 |
nmod |
operant,task |
R127 |
T209 |
T208 |
amod |
conditioning,operant |
R138 |
T223 |
T225 |
compound |
B,depletion |
R139 |
T224 |
T223 |
punct |
-,B |
R146 |
T232 |
T230 |
parataxis |
mosaic,variable |
R147 |
T233 |
T232 |
punct |
“,mosaic |
R157 |
T243 |
T241 |
pobj |
memory,with |
R158 |
T244 |
T243 |
amod |
olfactory,memory |
R170 |
T258 |
T256 |
pobj |
expression,by |
R171 |
T259 |
T260 |
compound |
GluR,B |
R173 |
T261 |
T260 |
punct |
-,B |
R182 |
T270 |
T252 |
advcl |
was,rescued |
R183 |
T271 |
T272 |
amod |
enhanced,discrimination |
R185 |
T273 |
T272 |
compound |
odor,discrimination |
R189 |
T277 |
T275 |
pobj |
variability,of |
R190 |
T278 |
T279 |
compound |
GluR,B |
R192 |
T280 |
T279 |
punct |
-,B |
R195 |
T283 |
T277 |
conj |
expression,variability |
R196 |
T284 |
T285 |
compound |
GluR,B |
R198 |
T286 |
T285 |
punct |
-,B |
R210 |
T300 |
T302 |
compound |
B,expression |
R211 |
T301 |
T300 |
punct |
-,B |
R214 |
T304 |
T290 |
dobj |
dissection,allowed |
R215 |
T305 |
T304 |
amod |
mechanistic,dissection |
R216 |
T306 |
T305 |
cc |
and,mechanistic |
R217 |
T307 |
T305 |
conj |
spatial,mechanistic |
R221 |
T311 |
T308 |
pobj |
capabilities,of |
R222 |
T312 |
T310 |
punct |
", ",learning |
R223 |
T313 |
T310 |
conj |
discrimination,learning |
R224 |
T314 |
T313 |
punct |
", ",discrimination |
R225 |
T315 |
T313 |
cc |
and,discrimination |
R226 |
T316 |
T313 |
conj |
memory,discrimination |
R228 |
T654 |
T965 |
punct |
),cells |
R229 |
T655 |
T656 |
det |
The,sense |
R230 |
T656 |
T657 |
nsubj |
sense,is |
R231 |
T658 |
T656 |
prep |
of,sense |
R232 |
T659 |
T658 |
pobj |
smell,of |
R233 |
T660 |
T657 |
prep |
of,is |
R234 |
T661 |
T662 |
amod |
paramount,importance |
R235 |
T662 |
T660 |
pobj |
importance,of |
R236 |
T663 |
T662 |
prep |
for,importance |
R237 |
T664 |
T663 |
pobj |
rodents,for |
R238 |
T665 |
T666 |
punct |
[,1 |
R239 |
T666 |
T664 |
parataxis |
1,rodents |
R240 |
T667 |
T666 |
punct |
],1 |
R241 |
T668 |
T664 |
punct |
", ",rodents |
R242 |
T669 |
T670 |
prep |
for,permits |
R243 |
T670 |
T664 |
relcl |
permits,rodents |
R244 |
T671 |
T669 |
pobj |
which,for |
R245 |
T672 |
T673 |
amod |
rapid,discrimination |
R246 |
T673 |
T670 |
nsubj |
discrimination,permits |
R247 |
T674 |
T673 |
compound |
odor,discrimination |
R248 |
T675 |
T673 |
cc |
and,discrimination |
R249 |
T676 |
T677 |
advmod |
long,lasting |
R250 |
T677 |
T679 |
amod |
lasting,memory |
R251 |
T678 |
T677 |
punct |
-,lasting |
R252 |
T679 |
T673 |
conj |
memory,discrimination |
R253 |
T680 |
T679 |
amod |
olfactory,memory |
R254 |
T681 |
T670 |
dobj |
responses,permits |
R255 |
T682 |
T681 |
prep |
to,responses |
R256 |
T683 |
T682 |
pobj |
predator,to |
R257 |
T684 |
T683 |
cc |
and,predator |
R258 |
T685 |
T683 |
conj |
prey,predator |
R259 |
T686 |
T681 |
amod |
critical,responses |
R260 |
T687 |
T686 |
prep |
for,critical |
R261 |
T688 |
T687 |
pobj |
survival,for |
R262 |
T689 |
T657 |
punct |
.,is |
R263 |
T691 |
T692 |
advmod |
Consequently,are |
R264 |
T693 |
T692 |
punct |
", ",are |
R265 |
T694 |
T695 |
det |
the,analyses |
R267 |
T696 |
T695 |
amod |
behavioral,analyses |
R268 |
T697 |
T695 |
prep |
of,analyses |
R269 |
T698 |
T699 |
amod |
olfactory,capabilities |
R270 |
T699 |
T697 |
pobj |
capabilities,of |
R271 |
T700 |
T699 |
prep |
in,capabilities |
R272 |
T701 |
T700 |
pobj |
rodents,in |
R273 |
T702 |
T692 |
acomp |
efficient,are |
R274 |
T703 |
T702 |
punct |
", ",efficient |
R275 |
T704 |
T702 |
conj |
quantitative,efficient |
R276 |
T705 |
T704 |
punct |
", ",quantitative |
R277 |
T706 |
T704 |
cc |
and,quantitative |
R278 |
T707 |
T704 |
conj |
reproducible,quantitative |
R279 |
T708 |
T709 |
punct |
[,2 |
R280 |
T709 |
T692 |
parataxis |
2,are |
R281 |
T710 |
T711 |
punct |
–,4 |
R282 |
T711 |
T709 |
prep |
4,2 |
R283 |
T712 |
T709 |
punct |
],2 |
R284 |
T713 |
T692 |
punct |
.,are |
R285 |
T715 |
T716 |
mark |
While,implicated |
R286 |
T716 |
T750 |
advcl |
implicated,delineated |
R287 |
T717 |
T716 |
prep |
in,implicated |
R288 |
T718 |
T719 |
det |
the,formation |
R289 |
T719 |
T717 |
pobj |
formation,in |
R290 |
T720 |
T719 |
cc |
and,formation |
R291 |
T721 |
T719 |
conj |
storage,formation |
R292 |
T722 |
T719 |
prep |
of,formation |
R293 |
T723 |
T724 |
amod |
olfactory,memory |
R294 |
T724 |
T722 |
pobj |
memory,of |
R295 |
T725 |
T726 |
amod |
piriform,cortex |
R296 |
T726 |
T716 |
nsubjpass |
cortex,implicated |
R297 |
T727 |
T728 |
punct |
[,5 |
R298 |
T728 |
T726 |
parataxis |
5,cortex |
R299 |
T729 |
T730 |
punct |
–,7 |
R300 |
T730 |
T728 |
prep |
7,5 |
R301 |
T731 |
T728 |
punct |
],5 |
R302 |
T732 |
T726 |
punct |
", ",cortex |
R303 |
T733 |
T726 |
conj |
hippocampus,cortex |
R304 |
T734 |
T735 |
punct |
[,9 |
R306 |
T736 |
T735 |
nummod |
8,9 |
R307 |
T737 |
T735 |
punct |
",",9 |
R308 |
T738 |
T735 |
punct |
],9 |
R309 |
T739 |
T733 |
punct |
", ",hippocampus |
R310 |
T740 |
T733 |
cc |
and,hippocampus |
R311 |
T741 |
T742 |
amod |
olfactory,bulb |
R312 |
T742 |
T733 |
conj |
bulb,hippocampus |
R313 |
T743 |
T744 |
punct |
[,10 |
R314 |
T744 |
T742 |
parataxis |
10,bulb |
R315 |
T745 |
T746 |
punct |
–,12 |
R316 |
T746 |
T744 |
prep |
12,10 |
R317 |
T747 |
T744 |
punct |
],10 |
R318 |
T748 |
T716 |
auxpass |
are,implicated |
R319 |
T749 |
T716 |
advmod |
all,implicated |
R320 |
T751 |
T750 |
punct |
", ",delineated |
R321 |
T752 |
T753 |
det |
the,correlates |
R323 |
T754 |
T753 |
amod |
cellular,correlates |
R324 |
T755 |
T753 |
prep |
for,correlates |
R325 |
T756 |
T757 |
det |
these,processes |
R326 |
T757 |
T755 |
pobj |
processes,for |
R327 |
T758 |
T750 |
aux |
have,delineated |
R328 |
T759 |
T750 |
neg |
not,delineated |
R329 |
T760 |
T750 |
auxpass |
been,delineated |
R330 |
T761 |
T750 |
advmod |
clearly,delineated |
R331 |
T762 |
T750 |
punct |
.,delineated |
R332 |
T764 |
T765 |
det |
The,contribution |
R333 |
T765 |
T766 |
nsubj |
contribution,is |
R334 |
T767 |
T765 |
prep |
of,contribution |
R335 |
T768 |
T769 |
det |
the,hippocampus |
R336 |
T769 |
T767 |
pobj |
hippocampus,of |
R337 |
T770 |
T765 |
prep |
to,contribution |
R338 |
T771 |
T772 |
amod |
olfactory,memory |
R339 |
T772 |
T770 |
pobj |
memory,to |
R340 |
T773 |
T766 |
advmod |
presently,is |
R341 |
T774 |
T766 |
acomp |
controversial,is |
R342 |
T775 |
T776 |
punct |
[,2 |
R343 |
T776 |
T766 |
parataxis |
2,is |
R344 |
T777 |
T776 |
punct |
",",2 |
R345 |
T778 |
T776 |
appos |
13,2 |
R346 |
T779 |
T780 |
punct |
–,18 |
R347 |
T780 |
T778 |
prep |
18,13 |
R348 |
T781 |
T776 |
punct |
],2 |
R349 |
T782 |
T766 |
punct |
", ",is |
R350 |
T783 |
T766 |
cc |
but,is |
R351 |
T784 |
T785 |
auxpass |
is,deemed |
R352 |
T785 |
T766 |
conj |
deemed,is |
R353 |
T786 |
T785 |
oprd |
unlikely,deemed |
R354 |
T787 |
T786 |
prep |
for,unlikely |
R355 |
T788 |
T789 |
amod |
simple,tasks |
R356 |
T789 |
T787 |
pobj |
tasks,for |
R357 |
T790 |
T791 |
amod |
olfactory,discrimination |
R358 |
T791 |
T789 |
compound |
discrimination,tasks |
R359 |
T792 |
T793 |
punct |
[,19 |
R360 |
T793 |
T785 |
parataxis |
19,deemed |
R361 |
T794 |
T793 |
nummod |
9,19 |
R362 |
T795 |
T793 |
punct |
",",19 |
R363 |
T796 |
T793 |
punct |
],19 |
R364 |
T797 |
T766 |
punct |
.,is |
R365 |
T799 |
T800 |
prep |
In,appear |
R366 |
T801 |
T799 |
pobj |
fact,In |
R367 |
T802 |
T800 |
punct |
", ",appear |
R368 |
T803 |
T804 |
det |
the,candidates |
R369 |
T804 |
T800 |
nsubj |
candidates,appear |
R370 |
T805 |
T806 |
advmod |
most,likely |
R371 |
T806 |
T804 |
amod |
likely,candidates |
R372 |
T807 |
T804 |
prep |
for,candidates |
R373 |
T808 |
T809 |
det |
a,correlate |
R375 |
T810 |
T809 |
amod |
cellular,correlate |
R376 |
T811 |
T809 |
prep |
of,correlate |
R377 |
T812 |
T813 |
amod |
olfactory,memory |
R378 |
T813 |
T811 |
pobj |
memory,of |
R379 |
T814 |
T815 |
aux |
to,be |
R380 |
T815 |
T800 |
xcomp |
be,appear |
R381 |
T816 |
T817 |
det |
the,connections |
R383 |
T818 |
T817 |
amod |
neuronal,connections |
R384 |
T819 |
T817 |
prep |
in,connections |
R385 |
T820 |
T821 |
det |
the,cortex |
R387 |
T822 |
T821 |
amod |
piriform,cortex |
R388 |
T823 |
T800 |
prep |
due,appear |
R389 |
T824 |
T823 |
pcomp |
to,due |
R390 |
T825 |
T826 |
det |
the,connectivity |
R392 |
T827 |
T826 |
amod |
associational,connectivity |
R393 |
T828 |
T829 |
punct |
[,5 |
R394 |
T829 |
T826 |
parataxis |
5,connectivity |
R395 |
T830 |
T829 |
punct |
],5 |
R396 |
T831 |
T826 |
cc |
and,connectivity |
R397 |
T832 |
T833 |
det |
the,expression |
R398 |
T833 |
T826 |
conj |
expression,connectivity |
R399 |
T834 |
T833 |
prep |
of,expression |
R400 |
T835 |
T836 |
amod |
several,forms |
R401 |
T836 |
T834 |
pobj |
forms,of |
R402 |
T837 |
T836 |
prep |
of,forms |
R403 |
T838 |
T839 |
amod |
cellular,plasticity |
R404 |
T839 |
T837 |
pobj |
plasticity,of |
R405 |
T840 |
T838 |
cc |
and,cellular |
R406 |
T841 |
T838 |
conj |
synaptic,cellular |
R407 |
T842 |
T843 |
punct |
[,7 |
R408 |
T843 |
T800 |
parataxis |
7,appear |
R409 |
T844 |
T843 |
punct |
",",7 |
R410 |
T845 |
T843 |
appos |
20,7 |
R411 |
T846 |
T847 |
punct |
–,23 |
R412 |
T847 |
T845 |
prep |
23,20 |
R413 |
T848 |
T843 |
punct |
],7 |
R414 |
T849 |
T800 |
punct |
.,appear |
R415 |
T851 |
T852 |
prep |
Concerning,attributed |
R416 |
T853 |
T854 |
compound |
odor,discrimination |
R417 |
T854 |
T851 |
pobj |
discrimination,Concerning |
R418 |
T855 |
T854 |
appos |
itself,discrimination |
R419 |
T856 |
T852 |
punct |
", ",attributed |
R420 |
T857 |
T858 |
amod |
cellular,mechanisms |
R421 |
T858 |
T852 |
nsubjpass |
mechanisms,attributed |
R422 |
T859 |
T858 |
prep |
for,mechanisms |
R423 |
T860 |
T861 |
det |
this,process |
R424 |
T861 |
T859 |
pobj |
process,for |
R425 |
T862 |
T852 |
auxpass |
are,attributed |
R426 |
T863 |
T852 |
advmod |
often,attributed |
R427 |
T864 |
T852 |
prep |
to,attributed |
R428 |
T865 |
T866 |
det |
the,circuitry |
R430 |
T867 |
T866 |
amod |
inhibitory,circuitry |
R431 |
T868 |
T866 |
prep |
of,circuitry |
R432 |
T869 |
T870 |
det |
the,bulb |
R434 |
T871 |
T870 |
amod |
olfactory,bulb |
R435 |
T872 |
T873 |
punct |
(,reviewed |
R436 |
T873 |
T852 |
parataxis |
reviewed,attributed |
R437 |
T874 |
T875 |
punct |
[,24 |
R438 |
T875 |
T873 |
parataxis |
24,reviewed |
R439 |
T876 |
T877 |
punct |
–,30 |
R440 |
T877 |
T875 |
prep |
30,24 |
R441 |
T878 |
T875 |
punct |
],24 |
R442 |
T879 |
T873 |
punct |
;,reviewed |
R443 |
T880 |
T873 |
prep |
in,reviewed |
R444 |
T881 |
T880 |
punct |
[,in |
R445 |
T882 |
T880 |
pobj |
31,in |
R446 |
T883 |
T884 |
punct |
–,33 |
R447 |
T884 |
T882 |
prep |
33,31 |
R448 |
T885 |
T873 |
punct |
],reviewed |
R449 |
T886 |
T873 |
punct |
),reviewed |
R450 |
T887 |
T852 |
punct |
.,attributed |
R451 |
T889 |
T890 |
amod |
Lateral,circuits |
R453 |
T891 |
T890 |
amod |
inhibitory,circuits |
R454 |
T893 |
T892 |
auxpass |
were,postulated |
R455 |
T894 |
T892 |
punct |
", ",postulated |
R456 |
T895 |
T892 |
prep |
in,postulated |
R457 |
T896 |
T895 |
pobj |
analogy,in |
R458 |
T897 |
T896 |
prep |
to,analogy |
R459 |
T898 |
T897 |
pobj |
retina,to |
R460 |
T899 |
T900 |
punct |
[,35 |
R461 |
T900 |
T892 |
parataxis |
35,postulated |
R462 |
T901 |
T900 |
nummod |
34,35 |
R463 |
T902 |
T900 |
punct |
",",35 |
R464 |
T903 |
T900 |
punct |
],35 |
R465 |
T904 |
T892 |
punct |
", ",postulated |
R466 |
T905 |
T906 |
aux |
to,mediate |
R467 |
T906 |
T892 |
advcl |
mediate,postulated |
R468 |
T907 |
T908 |
compound |
contrast,enhancement |
R469 |
T908 |
T906 |
dobj |
enhancement,mediate |
R470 |
T909 |
T910 |
punct |
[,24 |
R471 |
T910 |
T908 |
parataxis |
24,enhancement |
R472 |
T911 |
T910 |
punct |
],24 |
R473 |
T912 |
T908 |
punct |
", ",enhancement |
R474 |
T913 |
T914 |
prep |
for,provide |
R475 |
T914 |
T908 |
relcl |
provide,enhancement |
R476 |
T915 |
T913 |
pobj |
which,for |
R477 |
T916 |
T917 |
amod |
physiological,recordings |
R478 |
T917 |
T914 |
nsubj |
recordings,provide |
R479 |
T918 |
T919 |
punct |
[,37 |
R480 |
T919 |
T917 |
parataxis |
37,recordings |
R481 |
T920 |
T919 |
nummod |
24,37 |
R482 |
T921 |
T919 |
punct |
",",37 |
R483 |
T922 |
T919 |
nummod |
36,37 |
R484 |
T923 |
T919 |
punct |
",",37 |
R485 |
T924 |
T919 |
punct |
],37 |
R486 |
T925 |
T917 |
cc |
and,recordings |
R487 |
T926 |
T927 |
compound |
modeling,data |
R488 |
T927 |
T917 |
conj |
data,recordings |
R489 |
T928 |
T927 |
punct |
", ",data |
R490 |
T929 |
T927 |
prep |
based,data |
R491 |
T930 |
T929 |
prep |
on,based |
R492 |
T931 |
T932 |
det |
the,anatomy |
R493 |
T932 |
T930 |
pobj |
anatomy,on |
R494 |
T933 |
T934 |
advmod |
well,known |
R495 |
T934 |
T932 |
amod |
known,anatomy |
R496 |
T935 |
T934 |
punct |
-,known |
R497 |
T936 |
T937 |
punct |
[,29 |
R498 |
T937 |
T927 |
parataxis |
29,data |
R499 |
T938 |
T937 |
punct |
],29 |
R500 |
T939 |
T914 |
punct |
", ",provide |
R501 |
T940 |
T941 |
amod |
additional,support |
R502 |
T941 |
T914 |
dobj |
support,provide |
R503 |
T942 |
T892 |
punct |
.,postulated |
R504 |
T944 |
T945 |
amod |
Such,enhancement |
R506 |
T946 |
T945 |
compound |
contrast,enhancement |
R507 |
T948 |
T947 |
aux |
may,rest |
R508 |
T949 |
T947 |
prep |
in,rest |
R509 |
T950 |
T951 |
amod |
large,part |
R510 |
T951 |
T949 |
pobj |
part,in |
R511 |
T952 |
T947 |
prep |
on,rest |
R512 |
T953 |
T954 |
det |
the,properties |
R514 |
T955 |
T954 |
amod |
particular,properties |
R515 |
T956 |
T954 |
prep |
of,properties |
R516 |
T957 |
T958 |
amod |
dendrodendritic,synapses |
R517 |
T958 |
T956 |
pobj |
synapses,of |
R518 |
T959 |
T958 |
prep |
between,synapses |
R519 |
T960 |
T961 |
det |
the,neurons |
R520 |
T961 |
T959 |
pobj |
neurons,between |
R521 |
T962 |
T961 |
amod |
principal,neurons |
R522 |
T963 |
T961 |
compound |
output,neurons |
R523 |
T964 |
T965 |
punct |
(,cells |
R525 |
T966 |
T965 |
amod |
mitral,cells |
R528 |
T969 |
T961 |
conj |
neurons,neurons |
R529 |
T970 |
T969 |
amod |
inhibitory,neurons |
R531 |
T972 |
T969 |
parataxis |
cells,neurons |
R532 |
T973 |
T972 |
compound |
granule,cells |
R536 |
T977 |
T975 |
pobj |
bulb,of |
R537 |
T978 |
T977 |
amod |
olfactory,bulb |
R541 |
T984 |
T981 |
pobj |
synapses,In |
R542 |
T985 |
T984 |
amod |
distinct,synapses |
R545 |
T988 |
T982 |
nsubjpass |
inhibition,controlled |
R546 |
T989 |
T987 |
cc |
and,lateral |
R547 |
T990 |
T987 |
conj |
recurrent,lateral |
R551 |
T994 |
T992 |
pobj |
system,by |
R552 |
T995 |
T996 |
npadvmod |
gamma,aminobutyric |
R554 |
T997 |
T996 |
punct |
-,aminobutyric |
R555 |
T998 |
T999 |
compound |
acid,A |
R557 |
T1000 |
T999 |
punct |
-,A |
R565 |
T1008 |
T1006 |
pobj |
part,of |
R566 |
T1009 |
T1010 |
advmod |
closely,appositioned |
R567 |
T1010 |
T1008 |
amod |
appositioned,part |
R568 |
T1011 |
T1008 |
amod |
glutamatergic,part |
R573 |
T1016 |
T1014 |
dobj |
release,triggering |
R574 |
T1017 |
T1018 |
npadvmod |
gamma,aminobutyric |
R576 |
T1019 |
T1018 |
punct |
-,aminobutyric |
R577 |
T1020 |
T1016 |
compound |
acid,release |
R580 |
T1023 |
T1021 |
pobj |
influx,by |
R581 |
T1024 |
T1022 |
punct |
+,Ca2 |
R584 |
T1027 |
T1029 |
amod |
gated,channels |
R585 |
T1028 |
T1027 |
punct |
-,gated |
R586 |
T1029 |
T1025 |
pobj |
channels,through |
R587 |
T1030 |
T1029 |
compound |
receptor,channels |
R589 |
T1032 |
T982 |
parataxis |
38,controlled |
R590 |
T1033 |
T1032 |
punct |
[,38 |
R602 |
T1047 |
T1044 |
pcomp |
rely,Given |
R603 |
T1048 |
T1049 |
amod |
neuronal,circuits |
R604 |
T1049 |
T1047 |
nsubj |
circuits,rely |
R605 |
T1050 |
T1049 |
acl |
underlying,circuits |
R606 |
T1051 |
T1052 |
compound |
odor,discrimination |
R607 |
T1052 |
T1050 |
dobj |
discrimination,underlying |
R608 |
T1053 |
T1052 |
punct |
", ",discrimination |
R609 |
T1054 |
T1055 |
advmod |
as,as |
R611 |
T1056 |
T1055 |
advmod |
well,as |
R612 |
T1057 |
T1058 |
amod |
olfactory,memory |
R613 |
T1058 |
T1052 |
conj |
memory,discrimination |
R614 |
T1059 |
T1047 |
punct |
", ",rely |
R619 |
T1064 |
T1062 |
pobj |
neurotransmission,of |
R620 |
T1065 |
T1064 |
amod |
excitatory,neurotransmission |
R624 |
T1069 |
T1071 |
nmod |
amino,isoxazolepropionate |
R625 |
T1070 |
T1069 |
punct |
-,amino |
R626 |
T1071 |
T1083 |
compound |
isoxazolepropionate,receptors |
R627 |
T1072 |
T1071 |
punct |
-,isoxazolepropionate |
R628 |
T1073 |
T1074 |
nummod |
3,hydroxy |
R630 |
T1075 |
T1074 |
punct |
-,hydroxy |
R631 |
T1076 |
T1071 |
punct |
-,isoxazolepropionate |
R632 |
T1077 |
T1078 |
nummod |
5,methyl |
R634 |
T1079 |
T1078 |
punct |
-,methyl |
R635 |
T1080 |
T1071 |
punct |
-,isoxazolepropionate |
R636 |
T1081 |
T1071 |
nummod |
4,isoxazolepropionate |
R637 |
T1082 |
T1071 |
punct |
-,isoxazolepropionate |
R652 |
T1097 |
T1090 |
dobj |
contribution,alter |
R653 |
T1098 |
T1097 |
amod |
specific,contribution |
R654 |
T1099 |
T1097 |
amod |
functional,contribution |
R657 |
T1102 |
T1104 |
nmod |
amino,isoxazolepropionate |
R658 |
T1103 |
T1102 |
punct |
-,amino |
R659 |
T1104 |
T1116 |
nmod |
isoxazolepropionate,channels |
R660 |
T1105 |
T1104 |
punct |
-,isoxazolepropionate |
R661 |
T1106 |
T1107 |
nummod |
3,hydroxy |
R663 |
T1108 |
T1107 |
punct |
-,hydroxy |
R664 |
T1109 |
T1104 |
punct |
-,isoxazolepropionate |
R665 |
T1110 |
T1111 |
nummod |
5,methyl |
R667 |
T1112 |
T1111 |
punct |
-,methyl |
R668 |
T1113 |
T1104 |
punct |
-,isoxazolepropionate |
R669 |
T1114 |
T1104 |
nummod |
4,isoxazolepropionate |
R670 |
T1115 |
T1104 |
punct |
-,isoxazolepropionate |
R671 |
T1116 |
T1100 |
pobj |
channels,of |
R672 |
T1117 |
T1104 |
punct |
(,isoxazolepropionate |
R673 |
T1118 |
T1104 |
appos |
AMPA,isoxazolepropionate |
R674 |
T1119 |
T1116 |
punct |
),channels |
R677 |
T1122 |
T1120 |
dobj |
subunit,containing |
R678 |
T1123 |
T1122 |
amod |
dominant,subunit |
R680 |
T1125 |
T1122 |
appos |
B,subunit |
R681 |
T1126 |
T1125 |
punct |
-,B |
R685 |
T1132 |
T1129 |
pobj |
constituents,Of |
R686 |
T1133 |
T1132 |
nummod |
four,constituents |
R687 |
T1134 |
T1132 |
compound |
AMPAR,constituents |
R690 |
T1137 |
T1132 |
appos |
A,constituents |
R691 |
T1138 |
T1137 |
punct |
-,A |
R702 |
T1150 |
T1148 |
dobj |
channels,form |
R703 |
T1151 |
T1150 |
prep |
with,channels |
R704 |
T1152 |
T1153 |
amod |
different,combinations |
R705 |
T1153 |
T1151 |
pobj |
combinations,with |
R708 |
T1156 |
T1130 |
punct |
", ",contained |
R709 |
T1157 |
T1158 |
compound |
GluR,B |
R710 |
T1158 |
T1130 |
nsubjpass |
B,contained |
R712 |
T1160 |
T1130 |
auxpass |
is,contained |
R713 |
T1161 |
T1130 |
prep |
in,contained |
R714 |
T1162 |
T1163 |
det |
the,majority |
R715 |
T1149 |
T1150 |
amod |
tetrameric,channels |
R716 |
T1164 |
T1163 |
prep |
of,majority |
R717 |
T1165 |
T1164 |
pobj |
AMPARs,of |
R718 |
T1166 |
T1130 |
punct |
.,contained |
R719 |
T1163 |
T1161 |
pobj |
majority,in |
R721 |
T1169 |
T1171 |
nsubjpass |
B,involved |
R722 |
T1172 |
T1171 |
auxpass |
is,involved |
R723 |
T1170 |
T1169 |
punct |
-,B |
R724 |
T1174 |
T1171 |
prep |
in,involved |
R725 |
T1175 |
T1176 |
det |
the,formation |
R726 |
T1176 |
T1174 |
pobj |
formation,in |
R727 |
T1177 |
T1176 |
cc |
and,formation |
R728 |
T1178 |
T1176 |
conj |
trafficking,formation |
R729 |
T1173 |
T1171 |
advmod |
critically,involved |
R730 |
T1180 |
T1179 |
pobj |
AMPARs,of |
R731 |
T1181 |
T1171 |
punct |
", ",involved |
R732 |
T1179 |
T1176 |
prep |
of,formation |
R733 |
T1183 |
T1171 |
conj |
dominates,involved |
R734 |
T1184 |
T1185 |
poss |
their,conductance |
R735 |
T1185 |
T1183 |
dobj |
conductance,dominates |
R737 |
T1182 |
T1171 |
cc |
and,involved |
R738 |
T1188 |
T1189 |
compound |
gating,properties |
R739 |
T1189 |
T1185 |
conj |
properties,conductance |
R740 |
T1187 |
T1185 |
cc |
and,conductance |
R741 |
T1191 |
T1183 |
parataxis |
40,dominates |
R742 |
T1192 |
T1193 |
punct |
–,46 |
R743 |
T1190 |
T1191 |
punct |
[,40 |
R744 |
T1194 |
T1191 |
punct |
],40 |
R745 |
T1195 |
T1171 |
punct |
.,involved |
R746 |
T1193 |
T1191 |
prep |
46,40 |
R749 |
T1201 |
T1198 |
nsubjpass |
permeability,mediated |
R750 |
T1200 |
T1201 |
det |
the,permeability |
R753 |
T1202 |
T1203 |
advmod |
normally,low |
R754 |
T1206 |
T1201 |
prep |
of,permeability |
R755 |
T1207 |
T1208 |
compound |
AMPA,channels |
R756 |
T1205 |
T1204 |
punct |
+,Ca2 |
R757 |
T1209 |
T1236 |
amod |
critical,site |
R759 |
T1211 |
T1380 |
prep |
of,ablation |
R760 |
T1208 |
T1206 |
pobj |
channels,of |
R761 |
T1214 |
T1210 |
pobj |
neurons,in |
R762 |
T1215 |
T1198 |
auxpass |
is,mediated |
R763 |
T1212 |
T1214 |
amod |
principal,neurons |
R764 |
T1216 |
T1198 |
advmod |
solely,mediated |
R765 |
T1217 |
T1198 |
agent |
by,mediated |
R766 |
T1218 |
T1643 |
nummod |
55,57 |
R767 |
T1213 |
T1444 |
amod |
synaptic,plasticity |
R768 |
T1220 |
T1217 |
pobj |
B,by |
R769 |
T1221 |
T1220 |
punct |
-,B |
R770 |
T1219 |
T1220 |
compound |
GluR,B |
R771 |
T1223 |
T1717 |
punct |
", ",exploited |
R772 |
T1225 |
T1224 |
pcomp |
to,due |
R773 |
T1222 |
T1198 |
punct |
", ",mediated |
R774 |
T1227 |
T1228 |
det |
a,residue |
R775 |
T1224 |
T1198 |
prep |
due,mediated |
R776 |
T1228 |
T1224 |
pobj |
residue,due |
R777 |
T1226 |
T1854 |
punct |
“,rescue |
R778 |
T1230 |
T1228 |
compound |
arginine,residue |
R779 |
T1231 |
T1232 |
punct |
(,R587 |
R780 |
T1229 |
T1228 |
amod |
unique,residue |
R781 |
T1233 |
T1232 |
punct |
),R587 |
R782 |
T1234 |
T1228 |
prep |
in,residue |
R783 |
T1235 |
T1236 |
det |
the,site |
R784 |
T1232 |
T1228 |
parataxis |
R587,residue |
R785 |
T1237 |
T1209 |
advmod |
functionally,critical |
R786 |
T1239 |
T1236 |
nmod |
arginine,site |
R787 |
T1236 |
T1234 |
pobj |
site,in |
R788 |
T1238 |
T1239 |
nmod |
glutamine,arginine |
R789 |
T1241 |
T1242 |
punct |
(,R |
R790 |
T1242 |
T1236 |
parataxis |
R,site |
R791 |
T1240 |
T1239 |
punct |
/,arginine |
R792 |
T1244 |
T1242 |
punct |
/,R |
R793 |
T1245 |
T1242 |
punct |
),R |
R794 |
T1243 |
T1242 |
compound |
Q,R |
R795 |
T1247 |
T1248 |
det |
the,M2 |
R797 |
T1246 |
T1236 |
prep |
of,site |
R798 |
T1250 |
T1248 |
amod |
forming,M2 |
R799 |
T1249 |
T1250 |
npadvmod |
pore,forming |
R800 |
T1252 |
T1248 |
compound |
segment,M2 |
R801 |
T1251 |
T1250 |
punct |
-,forming |
R803 |
T1253 |
T1254 |
punct |
[,48 |
R804 |
T1256 |
T1254 |
punct |
",",48 |
R805 |
T1257 |
T1254 |
nummod |
47,48 |
R806 |
T1255 |
T1254 |
nummod |
44,48 |
R807 |
T1259 |
T1254 |
punct |
],48 |
R808 |
T1260 |
T1228 |
punct |
", ",residue |
R809 |
T1258 |
T1254 |
punct |
",",48 |
R810 |
T1262 |
T1261 |
prep |
from,resulting |
R811 |
T1263 |
T1264 |
compound |
RNA,editing |
R812 |
T1264 |
T1262 |
pobj |
editing,from |
R813 |
T1261 |
T1228 |
acl |
resulting,residue |
R814 |
T1266 |
T1267 |
compound |
GluR,B |
R815 |
T1267 |
T1269 |
compound |
B,pre-mRNA |
R816 |
T1265 |
T1264 |
prep |
of,editing |
R817 |
T1269 |
T1265 |
pobj |
pre-mRNA,of |
R818 |
T1270 |
T1271 |
punct |
(,49 |
R819 |
T1268 |
T1267 |
punct |
-,B |
R820 |
T1272 |
T1271 |
punct |
[,49 |
R821 |
T1273 |
T1271 |
punct |
],49 |
R822 |
T1271 |
T1198 |
parataxis |
49,mediated |
R823 |
T1275 |
T1271 |
advcl |
reviewed,49 |
R824 |
T1276 |
T1275 |
prep |
in,reviewed |
R825 |
T1274 |
T1271 |
punct |
;,49 |
R826 |
T1278 |
T1276 |
pobj |
50,in |
R827 |
T1279 |
T1271 |
punct |
],49 |
R828 |
T1280 |
T1271 |
punct |
),49 |
R829 |
T1281 |
T1198 |
punct |
.,mediated |
R830 |
T1277 |
T1276 |
punct |
[,in |
R831 |
T1283 |
T1284 |
advmod |
Hence,leads |
R832 |
T1286 |
T1287 |
preconj |
either,deficiency |
R833 |
T1287 |
T1284 |
nsubj |
deficiency,leads |
R834 |
T1285 |
T1284 |
punct |
", ",leads |
R835 |
T1289 |
T1287 |
compound |
B,deficiency |
R836 |
T1290 |
T1289 |
punct |
-,B |
R837 |
T1288 |
T1289 |
compound |
GluR,B |
R838 |
T1292 |
T1287 |
cc |
or,deficiency |
R839 |
T1293 |
T1294 |
det |
the,expression |
R840 |
T1291 |
T1287 |
punct |
", ",deficiency |
R841 |
T1295 |
T1294 |
prep |
of,expression |
R842 |
T1296 |
T1297 |
nmod |
Q,R |
R843 |
T1294 |
T1287 |
conj |
expression,deficiency |
R844 |
T1298 |
T1297 |
punct |
/,R |
R845 |
T1299 |
T1295 |
pobj |
B,of |
R846 |
T1297 |
T1299 |
nmod |
R,B |
R847 |
T1301 |
T1299 |
amod |
unedited,B |
R848 |
T1303 |
T1299 |
compound |
GluR,B |
R849 |
T1300 |
T1301 |
npadvmod |
site,unedited |
R850 |
T1302 |
T1301 |
punct |
-,unedited |
R851 |
T1305 |
T1299 |
prep |
with,B |
R852 |
T1306 |
T1307 |
det |
a,residue |
R853 |
T1304 |
T1299 |
punct |
-,B |
R854 |
T1308 |
T1307 |
compound |
glutamine,residue |
R855 |
T1309 |
T1307 |
prep |
at,residue |
R856 |
T1307 |
T1305 |
pobj |
residue,with |
R857 |
T1311 |
T1309 |
pobj |
site,at |
R858 |
T1310 |
T1311 |
det |
the,site |
R859 |
T1313 |
T1311 |
compound |
channel,site |
R860 |
T1314 |
T1284 |
punct |
", ",leads |
R861 |
T1312 |
T1311 |
amod |
critical,site |
R862 |
T1316 |
T1317 |
amod |
increased,permeability |
R863 |
T1317 |
T1315 |
pobj |
permeability,to |
R864 |
T1315 |
T1284 |
prep |
to,leads |
R865 |
T1319 |
T1318 |
punct |
+,Ca2 |
R866 |
T1320 |
T1317 |
prep |
of,permeability |
R867 |
T1318 |
T1317 |
nmod |
Ca2,permeability |
R868 |
T1322 |
T1320 |
pobj |
channels,of |
R869 |
T1323 |
T1284 |
punct |
", ",leads |
R870 |
T1321 |
T1322 |
compound |
AMPA,channels |
R871 |
T1325 |
T1284 |
advcl |
demonstrated,leads |
R872 |
T1326 |
T1325 |
advmod |
amply,demonstrated |
R873 |
T1324 |
T1325 |
mark |
as,demonstrated |
R874 |
T1328 |
T1329 |
npadvmod |
gene,targeted |
R875 |
T1329 |
T1331 |
amod |
targeted,mice |
R876 |
T1327 |
T1325 |
prep |
in,demonstrated |
R877 |
T1331 |
T1327 |
pobj |
mice,in |
R878 |
T1332 |
T1333 |
punct |
[,60 |
R879 |
T1330 |
T1329 |
punct |
-,targeted |
R880 |
T1334 |
T1333 |
nummod |
51,60 |
R881 |
T1335 |
T1333 |
punct |
",",60 |
R882 |
T1333 |
T1284 |
parataxis |
60,leads |
R883 |
T1337 |
T1333 |
punct |
",",60 |
R884 |
T1336 |
T1333 |
nummod |
53,60 |
R885 |
T1339 |
T1333 |
punct |
",",60 |
R886 |
T1340 |
T1333 |
punct |
],60 |
R887 |
T1338 |
T1333 |
nummod |
58,60 |
R888 |
T1343 |
T1344 |
advmod |
Thus,generate |
R889 |
T1341 |
T1284 |
punct |
.,leads |
R890 |
T1345 |
T1344 |
punct |
", ",generate |
R891 |
T1347 |
T1344 |
nsubj |
absence,generate |
R892 |
T1348 |
T1347 |
prep |
of,absence |
R893 |
T1346 |
T1347 |
det |
the,absence |
R894 |
T1350 |
T1348 |
pobj |
B,of |
R895 |
T1351 |
T1350 |
punct |
-,B |
R896 |
T1349 |
T1350 |
compound |
GluR,B |
R897 |
T1353 |
T1347 |
cc |
or,absence |
R898 |
T1354 |
T1355 |
det |
the,expression |
R899 |
T1352 |
T1347 |
punct |
", ",absence |
R900 |
T1356 |
T1355 |
prep |
of,expression |
R901 |
T1357 |
T1358 |
nmod |
GluR,Q |
R902 |
T1358 |
T1356 |
pobj |
Q,of |
R903 |
T1355 |
T1347 |
conj |
expression,absence |
R904 |
T1360 |
T1358 |
nmod |
B,Q |
R905 |
T1361 |
T1358 |
punct |
(,Q |
R906 |
T1359 |
T1358 |
punct |
-,Q |
R907 |
T1363 |
T1347 |
prep |
in,absence |
R908 |
T1362 |
T1358 |
punct |
),Q |
R909 |
T1365 |
T1363 |
pobj |
bulb,in |
R910 |
T1364 |
T1365 |
det |
the,bulb |
R911 |
T1367 |
T1344 |
punct |
", ",generate |
R912 |
T1368 |
T1344 |
aux |
may,generate |
R913 |
T1366 |
T1365 |
amod |
olfactory,bulb |
R914 |
T1370 |
T1344 |
dobj |
inhibition,generate |
R915 |
T1371 |
T1344 |
prep |
in,generate |
R916 |
T1369 |
T1370 |
amod |
increased,inhibition |
R917 |
T1373 |
T1371 |
pobj |
cells,in |
R918 |
T1374 |
T1344 |
punct |
.,generate |
R919 |
T1372 |
T1373 |
amod |
mitral,cells |
R920 |
T1376 |
T1377 |
advmod |
Moreover,alter |
R921 |
T1378 |
T1377 |
punct |
", ",alter |
R922 |
T1379 |
T1380 |
det |
the,ablation |
R923 |
T1381 |
T1382 |
compound |
GluR,B |
R924 |
T1382 |
T1211 |
pobj |
B,of |
R925 |
T1380 |
T1377 |
nsubj |
ablation,alter |
R926 |
T1384 |
T1380 |
punct |
", ",ablation |
R927 |
T1385 |
T1380 |
cc |
but,ablation |
R928 |
T1383 |
T1382 |
punct |
-,B |
R929 |
T1387 |
T1380 |
conj |
changes,ablation |
R930 |
T1388 |
T1387 |
prep |
in,changes |
R931 |
T1386 |
T1385 |
advmod |
also,but |
R932 |
T1390 |
T1388 |
pobj |
extent,in |
R933 |
T1391 |
T1390 |
prep |
of,extent |
R934 |
T1389 |
T1390 |
det |
the,extent |
R935 |
T1393 |
T1395 |
compound |
R,editing |
R936 |
T1394 |
T1393 |
punct |
/,R |
R937 |
T1392 |
T1393 |
compound |
Q,R |
R938 |
T1396 |
T1395 |
compound |
site,editing |
R939 |
T1397 |
T1395 |
prep |
of,editing |
R940 |
T1395 |
T1391 |
pobj |
editing,of |
R941 |
T1399 |
T1397 |
pobj |
B,of |
R942 |
T1398 |
T1399 |
compound |
GluR,B |
R943 |
T1401 |
T1377 |
punct |
", ",alter |
R944 |
T1402 |
T1377 |
aux |
can,alter |
R945 |
T1400 |
T1399 |
punct |
-,B |
R946 |
T1404 |
T1377 |
dobj |
strength,alter |
R947 |
T1405 |
T1404 |
prep |
of,strength |
R948 |
T1403 |
T1404 |
det |
the,strength |
R949 |
T1407 |
T1405 |
pobj |
transmission,of |
R950 |
T1408 |
T1407 |
amod |
synaptic,transmission |
R951 |
T1406 |
T1407 |
amod |
excitatory,transmission |
R952 |
T1410 |
T1411 |
det |
the,populations |
R953 |
T1409 |
T1377 |
prep |
in,alter |
R954 |
T1412 |
T1413 |
advmod |
genetically,addressed |
R955 |
T1413 |
T1411 |
amod |
addressed,populations |
R956 |
T1411 |
T1409 |
pobj |
populations,in |
R957 |
T1415 |
T1416 |
punct |
[,60 |
R958 |
T1414 |
T1411 |
amod |
neuronal,populations |
R959 |
T1417 |
T1416 |
nummod |
51,60 |
R960 |
T1418 |
T1416 |
punct |
",",60 |
R961 |
T1416 |
T1377 |
parataxis |
60,alter |
R962 |
T1420 |
T1416 |
punct |
",",60 |
R963 |
T1421 |
T1416 |
punct |
],60 |
R964 |
T1419 |
T1416 |
nummod |
58,60 |
R965 |
T1423 |
T1424 |
advmod |
thus,shifting |
R966 |
T1422 |
T1377 |
punct |
", ",alter |
R967 |
T1425 |
T1424 |
advmod |
potentially,shifting |
R968 |
T1426 |
T1427 |
det |
the,balance |
R969 |
T1424 |
T1377 |
advcl |
shifting,alter |
R970 |
T1428 |
T1427 |
prep |
of,balance |
R971 |
T1429 |
T1430 |
amod |
excitatory,transmission |
R972 |
T1427 |
T1424 |
dobj |
balance,shifting |
R973 |
T1431 |
T1429 |
cc |
and,excitatory |
R974 |
T1432 |
T1429 |
conj |
inhibitory,excitatory |
R975 |
T1430 |
T1428 |
pobj |
transmission,of |
R976 |
T1434 |
T1435 |
det |
the,circuits |
R977 |
T1435 |
T1433 |
pobj |
circuits,in |
R978 |
T1433 |
T1424 |
prep |
in,shifting |
R979 |
T1437 |
T1377 |
punct |
.,alter |
R980 |
T1436 |
T1435 |
amod |
affected,circuits |
R981 |
T1439 |
T1440 |
advmod |
Similarly,alter |
R982 |
T1442 |
T1440 |
nsubj |
changes,alter |
R983 |
T1443 |
T1442 |
prep |
in,changes |
R984 |
T1441 |
T1440 |
punct |
", ",alter |
R985 |
T1445 |
T1442 |
prep |
due,changes |
R986 |
T1444 |
T1443 |
pobj |
plasticity,in |
R987 |
T1447 |
T1448 |
npadvmod |
Ca2,permeable |
R989 |
T1446 |
T1445 |
pcomp |
to,due |
R990 |
T1450 |
T1448 |
punct |
-,permeable |
R991 |
T1451 |
T1445 |
pobj |
AMPARs,due |
R992 |
T1449 |
T1447 |
punct |
+,Ca2 |
R993 |
T1453 |
T1451 |
parataxis |
60,AMPARs |
R994 |
T1452 |
T1453 |
punct |
[,60 |
R995 |
T1455 |
T1453 |
punct |
",",60 |
R996 |
T1454 |
T1453 |
nummod |
51,60 |
R997 |
T1457 |
T1453 |
punct |
",",60 |
R998 |
T1458 |
T1453 |
punct |
],60 |
R999 |
T1456 |
T1453 |
nummod |
52,60 |
R1000 |
T1460 |
T1461 |
advmod |
e.g.,in |
R1001 |
T1461 |
T1451 |
prep |
in,AMPARs |
R1002 |
T1459 |
T1451 |
punct |
", ",AMPARs |
R1003 |
T1463 |
T1464 |
amod |
piriform,cortex |
R1004 |
T1464 |
T1461 |
pobj |
cortex,in |
R1005 |
T1462 |
T1461 |
punct |
", ",in |
R1006 |
T1466 |
T1440 |
aux |
might,alter |
R1007 |
T1465 |
T1440 |
punct |
", ",alter |
R1008 |
T1468 |
T1469 |
compound |
memorization,processes |
R1009 |
T1467 |
T1468 |
compound |
odor,memorization |
R1010 |
T1470 |
T1440 |
punct |
.,alter |
R1011 |
T1469 |
T1440 |
dobj |
processes,alter |
R1012 |
T1472 |
T1473 |
advmod |
Thus,allow |
R1013 |
T1475 |
T1473 |
nsubj |
alterations,allow |
R1014 |
T1476 |
T1475 |
prep |
of,alterations |
R1015 |
T1474 |
T1473 |
punct |
", ",allow |
R1016 |
T1478 |
T1476 |
pobj |
properties,of |
R1017 |
T1479 |
T1475 |
prep |
in,alterations |
R1018 |
T1477 |
T1478 |
compound |
AMPAR,properties |
R1019 |
T1481 |
T1479 |
pobj |
regions,in |
R1020 |
T1480 |
T1481 |
det |
these,regions |
R1021 |
T1483 |
T1473 |
aux |
will,allow |
R1022 |
T1484 |
T1473 |
dobj |
investigation,allow |
R1023 |
T1482 |
T1481 |
compound |
brain,regions |
R1024 |
T1486 |
T1487 |
advmod |
possibly,separation |
R1025 |
T1485 |
T1484 |
cc |
and,investigation |
R1026 |
T1488 |
T1484 |
prep |
of,investigation |
R1027 |
T1487 |
T1484 |
conj |
separation,investigation |
R1028 |
T1490 |
T1489 |
acl |
underlying,mechanisms |
R1029 |
T1491 |
T1492 |
det |
these,traits |
R1030 |
T1489 |
T1488 |
pobj |
mechanisms,of |
R1031 |
T1493 |
T1492 |
amod |
behavioral,traits |
R1032 |
T1492 |
T1490 |
dobj |
traits,underlying |
R1033 |
T1496 |
T1497 |
prep |
Concerning,show |
R1035 |
T1494 |
T1473 |
punct |
.,allow |
R1036 |
T1500 |
T1499 |
amod |
intended,switch |
R1037 |
T1498 |
T1499 |
det |
this,switch |
R1038 |
T1502 |
T1503 |
compound |
AMPAR,properties |
R1039 |
T1501 |
T1499 |
prep |
in,switch |
R1040 |
T1504 |
T1497 |
punct |
", ",show |
R1041 |
T1505 |
T1497 |
nsubj |
mice,show |
R1042 |
T1503 |
T1501 |
pobj |
properties,in |
R1043 |
T1507 |
T1508 |
det |
all,B |
R1044 |
T1506 |
T1505 |
acl |
lacking,mice |
R1045 |
T1509 |
T1508 |
compound |
GluR,B |
R1046 |
T1510 |
T1508 |
punct |
-,B |
R1047 |
T1508 |
T1506 |
dobj |
B,lacking |
R1048 |
T1512 |
T1497 |
advmod |
however,show |
R1049 |
T1511 |
T1497 |
punct |
", ",show |
R1050 |
T1514 |
T1515 |
det |
a,impairment |
R1051 |
T1515 |
T1497 |
dobj |
impairment,show |
R1052 |
T1513 |
T1497 |
punct |
", ",show |
R1053 |
T1517 |
T1515 |
prep |
in,impairment |
R1054 |
T1516 |
T1515 |
amod |
widespread,impairment |
R1055 |
T1519 |
T1515 |
punct |
", ",impairment |
R1056 |
T1520 |
T1515 |
prep |
including,impairment |
R1057 |
T1518 |
T1517 |
pobj |
behavior,in |
R1058 |
T1522 |
T1521 |
punct |
", ",lethargy |
R1059 |
T1523 |
T1524 |
compound |
motor,coordination |
R1060 |
T1521 |
T1520 |
pobj |
lethargy,including |
R1061 |
T1525 |
T1521 |
conj |
problems,lethargy |
R1062 |
T1526 |
T1525 |
punct |
", ",problems |
R1063 |
T1524 |
T1525 |
compound |
coordination,problems |
R1064 |
T1528 |
T1525 |
conj |
deficits,problems |
R1065 |
T1529 |
T1528 |
prep |
in,deficits |
R1066 |
T1527 |
T1525 |
cc |
and,problems |
R1067 |
T1531 |
T1529 |
pobj |
activity,in |
R1068 |
T1530 |
T1531 |
amod |
exploratory,activity |
R1069 |
T1533 |
T1528 |
parataxis |
51,deficits |
R1070 |
T1534 |
T1533 |
punct |
],51 |
R1071 |
T1532 |
T1533 |
punct |
[,51 |
R1072 |
T1536 |
T1537 |
dep |
which,preclude |
R1073 |
T1537 |
T1528 |
relcl |
preclude,deficits |
R1074 |
T1535 |
T1528 |
punct |
", ",deficits |
R1075 |
T1539 |
T1537 |
dobj |
analyses,preclude |
R1076 |
T1538 |
T1539 |
amod |
detailed,analyses |
R1077 |
T1541 |
T1497 |
punct |
.,show |
R1078 |
T1540 |
T1539 |
amod |
behavioral,analyses |
R1079 |
T1543 |
T1544 |
advmod |
Similarly,become |
R1080 |
T1546 |
T1544 |
nsubj |
mice,become |
R1081 |
T1547 |
T1546 |
acl |
expressing,mice |
R1082 |
T1548 |
T1547 |
punct |
(,expressing |
R1083 |
T1549 |
T1547 |
prep |
in,expressing |
R1084 |
T1545 |
T1544 |
punct |
", ",become |
R1085 |
T1551 |
T1549 |
pobj |
brain,in |
R1086 |
T1552 |
T1551 |
amod |
entire,brain |
R1087 |
T1550 |
T1551 |
det |
the,brain |
R1088 |
T1554 |
T1555 |
det |
a,part |
R1089 |
T1553 |
T1547 |
punct |
),expressing |
R1090 |
T1556 |
T1555 |
amod |
substantial,part |
R1091 |
T1555 |
T1547 |
dobj |
part,expressing |
R1092 |
T1558 |
T1559 |
det |
the,population |
R1093 |
T1559 |
T1557 |
pobj |
population,of |
R1094 |
T1557 |
T1555 |
prep |
of,part |
R1095 |
T1561 |
T1559 |
compound |
B,population |
R1096 |
T1562 |
T1561 |
punct |
-,B |
R1097 |
T1560 |
T1561 |
compound |
GluR,B |
R1098 |
T1564 |
T1565 |
det |
the,form |
R1099 |
T1563 |
T1547 |
prep |
in,expressing |
R1100 |
T1566 |
T1567 |
nmod |
Q,R |
R1101 |
T1567 |
T1565 |
nmod |
R,form |
R1102 |
T1565 |
T1563 |
pobj |
form,in |
R1103 |
T1569 |
T1570 |
npadvmod |
site,unedited |
R1104 |
T1570 |
T1565 |
amod |
unedited,form |
R1105 |
T1568 |
T1567 |
punct |
/,R |
R1106 |
T1572 |
T1573 |
npadvmod |
seizure,prone |
R1107 |
T1571 |
T1570 |
punct |
-,unedited |
R1108 |
T1574 |
T1573 |
punct |
-,prone |
R1109 |
T1575 |
T1544 |
cc |
and,become |
R1110 |
T1573 |
T1544 |
acomp |
prone,become |
R1111 |
T1577 |
T1576 |
advmod |
prematurely,die |
R1112 |
T1578 |
T1579 |
punct |
[,53 |
R1113 |
T1576 |
T1544 |
conj |
die,become |
R1114 |
T1580 |
T1579 |
punct |
],53 |
R1115 |
T1579 |
T1576 |
parataxis |
53,die |
R1116 |
T1583 |
T1584 |
nsubjpass |
Some,overcome |
R1117 |
T1581 |
T1544 |
punct |
.,become |
R1118 |
T1585 |
T1583 |
prep |
of,Some |
R1119 |
T1586 |
T1587 |
det |
these,problems |
R1120 |
T1588 |
T1584 |
aux |
can,overcome |
R1121 |
T1589 |
T1584 |
auxpass |
be,overcome |
R1122 |
T1587 |
T1585 |
pobj |
problems,of |
R1123 |
T1591 |
T1584 |
prep |
by,overcome |
R1124 |
T1590 |
T1584 |
advmod |
partially,overcome |
R1125 |
T1593 |
T1592 |
prep |
of,use |
R1126 |
T1594 |
T1595 |
advmod |
spatially,restricted |
R1128 |
T1592 |
T1591 |
pobj |
use,by |
R1129 |
T1597 |
T1594 |
conj |
temporally,spatially |
R1130 |
T1598 |
T1593 |
pobj |
systems,of |
R1131 |
T1596 |
T1594 |
cc |
and,spatially |
R1132 |
T1600 |
T1601 |
punct |
[,54 |
R1133 |
T1601 |
T1598 |
parataxis |
54,systems |
R1134 |
T1599 |
T1598 |
compound |
expression,systems |
R1135 |
T1603 |
T1601 |
prep |
56,54 |
R1136 |
T1604 |
T1601 |
punct |
],54 |
R1137 |
T1602 |
T1603 |
punct |
–,56 |
R1138 |
T1606 |
T1607 |
prep |
in,system |
R1139 |
T1605 |
T1598 |
punct |
", ",systems |
R1140 |
T1608 |
T1606 |
amod |
particular,in |
R1141 |
T1609 |
T1607 |
det |
the,system |
R1142 |
T1610 |
T1611 |
compound |
Cre,lox |
R1143 |
T1607 |
T1598 |
appos |
system,systems |
R1144 |
T1612 |
T1611 |
punct |
-,lox |
R1145 |
T1613 |
T1584 |
punct |
", ",overcome |
R1146 |
T1611 |
T1607 |
compound |
lox,system |
R1147 |
T1615 |
T1584 |
advcl |
marked,overcome |
R1148 |
T1614 |
T1615 |
mark |
with,marked |
R1149 |
T1617 |
T1619 |
compound |
recombinase,expression |
R1150 |
T1618 |
T1617 |
punct |
-,recombinase |
R1151 |
T1619 |
T1615 |
nsubj |
expression,marked |
R1152 |
T1616 |
T1617 |
compound |
Cre,recombinase |
R1153 |
T1621 |
T1622 |
amod |
defined,areas |
R1154 |
T1620 |
T1619 |
prep |
in,expression |
R1155 |
T1623 |
T1622 |
compound |
brain,areas |
R1156 |
T1624 |
T1622 |
prep |
of,areas |
R1157 |
T1622 |
T1620 |
pobj |
areas,in |
R1158 |
T1626 |
T1628 |
amod |
targeted,mice |
R1159 |
T1625 |
T1626 |
npadvmod |
gene,targeted |
R1160 |
T1628 |
T1624 |
pobj |
mice,of |
R1161 |
T1627 |
T1626 |
punct |
-,targeted |
R1162 |
T1630 |
T1631 |
compound |
GluR,B |
R1163 |
T1631 |
T1633 |
compound |
B,alleles |
R1164 |
T1629 |
T1628 |
acl |
carrying,mice |
R1165 |
T1633 |
T1629 |
dobj |
alleles,carrying |
R1166 |
T1632 |
T1631 |
punct |
-,B |
R1167 |
T1635 |
T1636 |
compound |
loxP,sites |
R1168 |
T1636 |
T1634 |
pobj |
sites,by |
R1169 |
T1634 |
T1615 |
agent |
by,marked |
R1170 |
T1638 |
T1639 |
npadvmod |
Cre,mediated |
R1171 |
T1637 |
T1636 |
prep |
for,sites |
R1172 |
T1640 |
T1639 |
punct |
-,mediated |
R1173 |
T1641 |
T1637 |
pobj |
recombination,for |
R1174 |
T1639 |
T1641 |
amod |
mediated,recombination |
R1176 |
T1642 |
T1643 |
punct |
[,57 |
R1177 |
T1645 |
T1643 |
punct |
],57 |
R1178 |
T1646 |
T1584 |
punct |
.,overcome |
R1179 |
T1644 |
T1643 |
punct |
",",57 |
R1180 |
T1648 |
T1649 |
advmod |
Indeed,resulted |
R1181 |
T1650 |
T1649 |
punct |
", ",resulted |
R1182 |
T1652 |
T1653 |
det |
the,expression |
R1183 |
T1653 |
T1651 |
dobj |
expression,restricting |
R1184 |
T1651 |
T1649 |
csubj |
restricting,resulted |
R1185 |
T1655 |
T1656 |
nmod |
Q,R |
R1187 |
T1654 |
T1653 |
prep |
of,expression |
R1188 |
T1658 |
T1654 |
pobj |
B,of |
R1189 |
T1657 |
T1656 |
punct |
/,R |
R1190 |
T1660 |
T1658 |
amod |
unedited,B |
R1191 |
T1659 |
T1660 |
npadvmod |
site,unedited |
R1192 |
T1662 |
T1658 |
compound |
GluR,B |
R1193 |
T1663 |
T1658 |
punct |
-,B |
R1194 |
T1661 |
T1660 |
punct |
-,unedited |
R1195 |
T1665 |
T1664 |
pobj |
forebrain,to |
R1196 |
T1666 |
T1649 |
prep |
in,resulted |
R1197 |
T1664 |
T1651 |
prep |
to,restricting |
R1198 |
T1668 |
T1669 |
amod |
normal,lifespan |
R1199 |
T1669 |
T1666 |
pobj |
lifespan,in |
R1200 |
T1667 |
T1668 |
advmod |
almost,normal |
R1201 |
T1671 |
T1672 |
det |
an,phenotype |
R1202 |
T1672 |
T1669 |
conj |
phenotype,lifespan |
R1203 |
T1670 |
T1669 |
cc |
and,lifespan |
R1204 |
T1674 |
T1675 |
advmod |
weakly,prone |
R1206 |
T1673 |
T1674 |
advmod |
only,weakly |
R1207 |
T1677 |
T1675 |
punct |
-,prone |
R1208 |
T1676 |
T1675 |
npadvmod |
seizure,prone |
R1209 |
T1679 |
T1649 |
parataxis |
58,resulted |
R1210 |
T1678 |
T1679 |
punct |
[,58 |
R1211 |
T1681 |
T1649 |
punct |
.,resulted |
R1212 |
T1680 |
T1679 |
punct |
],58 |
R1213 |
T1683 |
T1684 |
nsubj |
Mice,appeared |
R1214 |
T1685 |
T1683 |
prep |
with,Mice |
R1215 |
T1686 |
T1687 |
npadvmod |
forebrain,specific |
R1216 |
T1688 |
T1687 |
punct |
-,specific |
R1217 |
T1689 |
T1685 |
pobj |
depletion,with |
R1218 |
T1687 |
T1689 |
amod |
specific,depletion |
R1219 |
T1690 |
T1691 |
compound |
GluR,B |
R1220 |
T1692 |
T1691 |
punct |
-,B |
R1221 |
T1693 |
T1694 |
advmod |
almost,completely |
R1222 |
T1691 |
T1689 |
compound |
B,depletion |
R1223 |
T1695 |
T1684 |
oprd |
normal,appeared |
R1224 |
T1696 |
T1684 |
prep |
throughout,appeared |
R1225 |
T1694 |
T1695 |
advmod |
completely,normal |
R1226 |
T1698 |
T1684 |
prep |
with,appeared |
R1227 |
T1699 |
T1700 |
det |
no,abnormalities |
R1228 |
T1697 |
T1696 |
pobj |
life,throughout |
R1229 |
T1701 |
T1700 |
amod |
developmental,abnormalities |
R1230 |
T1702 |
T1684 |
punct |
", ",appeared |
R1231 |
T1700 |
T1698 |
pobj |
abnormalities,with |
R1232 |
T1704 |
T1684 |
advcl |
permitting,appeared |
R1233 |
T1703 |
T1704 |
advmod |
thus,permitting |
R1234 |
T1706 |
T1704 |
dobj |
investigation,permitting |
R1235 |
T1705 |
T1706 |
det |
a,investigation |
R1236 |
T1708 |
T1706 |
punct |
", ",investigation |
R1237 |
T1709 |
T1706 |
amod |
quantitative,investigation |
R1238 |
T1707 |
T1706 |
amod |
detailed,investigation |
R1239 |
T1711 |
T1712 |
amod |
olfactory,behavior |
R1240 |
T1712 |
T1710 |
pobj |
behavior,of |
R1241 |
T1710 |
T1706 |
prep |
of,investigation |
R1242 |
T1715 |
T1716 |
aux |
To,allow |
R1243 |
T1713 |
T1684 |
punct |
.,appeared |
R1244 |
T1718 |
T1716 |
prep |
for,allow |
R1245 |
T1716 |
T1717 |
advcl |
allow,exploited |
R1247 |
T1721 |
T1720 |
amod |
mechanistic,separation |
R1248 |
T1719 |
T1720 |
det |
the,separation |
R1249 |
T1723 |
T1724 |
amod |
olfactory,learning |
R1250 |
T1722 |
T1720 |
prep |
of,separation |
R1251 |
T1725 |
T1724 |
punct |
", ",learning |
R1252 |
T1724 |
T1722 |
pobj |
learning,of |
R1253 |
T1727 |
T1726 |
punct |
", ",discrimination |
R1254 |
T1728 |
T1726 |
cc |
and,discrimination |
R1255 |
T1726 |
T1724 |
conj |
discrimination,learning |
R1258 |
T1729 |
T1726 |
conj |
memory,discrimination |
R1259 |
T1733 |
T1734 |
advmod |
well,known |
R1263 |
T1735 |
T1734 |
punct |
-,known |
R1266 |
T1737 |
T1736 |
pobj |
transgenes,of |
R1268 |
T1740 |
T1732 |
relcl |
concerns,phenomenon |
R1270 |
T1742 |
T1740 |
dobj |
expression,concerns |
R1271 |
T1745 |
T1743 |
pobj |
lines,among |
R1272 |
T1744 |
T1745 |
amod |
different,lines |
R1274 |
T1746 |
T1745 |
compound |
founder,lines |
R1277 |
T1748 |
T1749 |
advmod |
even,among |
R1281 |
T1755 |
T1753 |
pobj |
line,of |
R1282 |
T1756 |
T1755 |
amod |
given,line |
R1285 |
T1760 |
T1766 |
advcl |
is,took |
R1286 |
T1761 |
T1762 |
amod |
such,expression |
R1287 |
T1762 |
T1760 |
nsubj |
expression,is |
R1288 |
T1763 |
T1762 |
punct |
“,expression |
R1289 |
T1764 |
T1762 |
nmod |
mosaic,expression |
R1290 |
T1751 |
T1752 |
amod |
identical,individuals |
R1293 |
T1765 |
T1762 |
punct |
”,expression |
R1296 |
T1769 |
T1766 |
punct |
", ",took |
R1299 |
T1772 |
T1766 |
dobj |
advantage,took |
R1301 |
T1775 |
T1766 |
prep |
by,took |
R1302 |
T1778 |
T1776 |
dobj |
B,ablating |
R1303 |
T1779 |
T1778 |
punct |
-,B |
R1304 |
T1777 |
T1778 |
compound |
GluR,B |
R1306 |
T1782 |
T1784 |
amod |
targeted,alleles |
R1307 |
T1780 |
T1776 |
prep |
via,ablating |
R1308 |
T1784 |
T1780 |
pobj |
alleles,via |
R1309 |
T1785 |
T1784 |
punct |
", ",alleles |
R1310 |
T1783 |
T1782 |
punct |
-,targeted |
R1311 |
T1787 |
T1788 |
compound |
GluR,B |
R1313 |
T1786 |
T1784 |
amod |
floxed,alleles |
R1316 |
T1789 |
T1788 |
punct |
-,B |
R1319 |
T1792 |
T1790 |
pobj |
help,with |
R1320 |
T1796 |
T1795 |
amod |
transgenic,line |
R1323 |
T1797 |
T1795 |
compound |
mouse,line |
R1324 |
T1800 |
T1798 |
pobj |
expression,with |
R1325 |
T1801 |
T1800 |
compound |
Cre,expression |
R1326 |
T1799 |
T1800 |
amod |
variegated,expression |
R1329 |
T1802 |
T1800 |
prep |
in,expression |
R1330 |
T1806 |
T1807 |
prep |
By,investigated |
R1331 |
T1808 |
T1806 |
pcomp |
correlating,By |
R1332 |
T1810 |
T1812 |
compound |
B,levels |
R1333 |
T1811 |
T1810 |
punct |
-,B |
R1335 |
T1809 |
T1810 |
compound |
GluR,B |
R1337 |
T1813 |
T1812 |
prep |
in,levels |
R1338 |
T1816 |
T1815 |
punct |
-,related |
R1339 |
T1815 |
T1817 |
amod |
related,regions |
R1340 |
T1818 |
T1817 |
compound |
brain,regions |
R1342 |
T1817 |
T1813 |
pobj |
regions,in |
R1343 |
T1821 |
T1819 |
pobj |
data,with |
R1344 |
T1822 |
T1821 |
amod |
behavioral,data |
R1345 |
T1820 |
T1821 |
amod |
quantitative,data |
R1349 |
T1823 |
T1807 |
punct |
", ",investigated |
R1351 |
T1829 |
T1827 |
pobj |
B,on |
R1352 |
T1827 |
T1826 |
prep |
on,dependence |
R1355 |
T1830 |
T1829 |
punct |
-,B |
R1358 |
T1833 |
T1831 |
pobj |
discrimination,of |
R1360 |
T1836 |
T1807 |
punct |
.,investigated |
R1361 |
T1840 |
T1839 |
punct |
", ",used |
R1364 |
T1841 |
T1842 |
aux |
to,delineate |
R1365 |
T1845 |
T1844 |
compound |
brain,areas |
R1366 |
T1844 |
T1842 |
dobj |
areas,delineate |
R1369 |
T1849 |
T1847 |
pobj |
processes,in |
R1370 |
T1846 |
T1844 |
acl |
involved,areas |
R1371 |
T1851 |
T1849 |
amod |
olfactory,processes |
R1373 |
T1850 |
T1849 |
amod |
distinctive,processes |
R1374 |
T1854 |
T1839 |
dobj |
rescue,used |
R1375 |
T1853 |
T1854 |
amod |
transgenic,rescue |
R1376 |
T1856 |
T1854 |
prep |
of,rescue |
R1377 |
T1857 |
T1858 |
compound |
GluR,B |
R1378 |
T1855 |
T1854 |
punct |
”,rescue |
R1421 |
T1900 |
T1898 |
conj |
discrimination,learning |
R1422 |
T1904 |
T1872 |
punct |
.,allowed |
R1423 |
T1903 |
T1900 |
conj |
memory,discrimination |
R1428 |
T2403 |
T2404 |
nmod |
GluR,B |
R1429 |
T2404 |
T2406 |
nmod |
B,Expression |
R1430 |
T2405 |
T2404 |
punct |
-,B |
R1431 |
T2406 |
T2410 |
nsubj |
Expression,Increases |
R1432 |
T2407 |
T2408 |
punct |
(,Q |
R1433 |
T2408 |
T2404 |
parataxis |
Q,B |
R1434 |
T2409 |
T2408 |
punct |
),Q |
R1435 |
T2411 |
T2406 |
prep |
in,Expression |
R1436 |
T2412 |
T2413 |
det |
the,Forebrain |
R1437 |
T2413 |
T2411 |
pobj |
Forebrain,in |
R1438 |
T2414 |
T2415 |
amod |
Olfactory,Learning |
R1439 |
T2415 |
T2410 |
dobj |
Learning,Increases |
R1440 |
T2416 |
T2415 |
cc |
and,Learning |
R1441 |
T2417 |
T2415 |
conj |
Discrimination,Learning |
R1442 |
T2419 |
T2420 |
aux |
To,explore |
R1443 |
T2420 |
T2421 |
advcl |
explore,analyzed |
R1444 |
T2422 |
T2423 |
det |
the,role |
R1445 |
T2423 |
T2420 |
dobj |
role,explore |
R1446 |
T2424 |
T2423 |
prep |
of,role |
R1447 |
T2425 |
T2426 |
amod |
fast,neurotransmission |
R1448 |
T2426 |
T2424 |
pobj |
neurotransmission,of |
R1449 |
T2427 |
T2426 |
amod |
excitatory,neurotransmission |
R1450 |
T2428 |
T2426 |
acl |
carried,neurotransmission |
R1451 |
T2429 |
T2428 |
prep |
by,carried |
R1452 |
T2430 |
T2431 |
compound |
GluR,B |
R1453 |
T2431 |
T2433 |
npadvmod |
B,containing |
R1454 |
T2432 |
T2431 |
punct |
-,B |
R1455 |
T2433 |
T2435 |
amod |
containing,channels |
R1456 |
T2434 |
T2433 |
punct |
-,containing |
R1457 |
T2435 |
T2429 |
pobj |
channels,by |
R1458 |
T2436 |
T2435 |
compound |
AMPA,channels |
R1459 |
T2437 |
T2423 |
prep |
in,role |
R1460 |
T2438 |
T2439 |
amod |
olfactory,processes |
R1461 |
T2439 |
T2437 |
pobj |
processes,in |
R1462 |
T2440 |
T2421 |
punct |
", ",analyzed |
R1463 |
T2441 |
T2421 |
nsubj |
we,analyzed |
R1464 |
T2442 |
T2421 |
advmod |
first,analyzed |
R1465 |
T2443 |
T2421 |
dobj |
mice,analyzed |
R1466 |
T2444 |
T2445 |
dep |
that,express |
R1467 |
T2445 |
T2443 |
relcl |
express,mice |
R1468 |
T2446 |
T2445 |
dobj |
part,express |
R1469 |
T2447 |
T2446 |
prep |
of,part |
R1470 |
T2448 |
T2449 |
det |
the,population |
R1471 |
T2449 |
T2447 |
pobj |
population,of |
R1472 |
T2450 |
T2451 |
compound |
GluR,B |
R1473 |
T2451 |
T2449 |
compound |
B,population |
R1474 |
T2452 |
T2451 |
punct |
-,B |
R1475 |
T2453 |
T2445 |
prep |
in,express |
R1476 |
T2454 |
T2455 |
det |
a,form |
R1477 |
T2455 |
T2453 |
pobj |
form,in |
R1478 |
T2456 |
T2457 |
compound |
Q,R |
R1479 |
T2457 |
T2459 |
compound |
R,site |
R1480 |
T2458 |
T2457 |
punct |
/,R |
R1481 |
T2459 |
T2460 |
npadvmod |
site,unedited |
R1482 |
T2460 |
T2455 |
amod |
unedited,form |
R1483 |
T2461 |
T2460 |
punct |
-,unedited |
R1484 |
T2462 |
T2463 |
punct |
(,1A |
R1485 |
T2463 |
T2421 |
parataxis |
1A,analyzed |
R1486 |
T2464 |
T2463 |
compound |
Figure,1A |
R1487 |
T2465 |
T2463 |
punct |
;,1A |
R1488 |
T2466 |
T2463 |
advcl |
termed,1A |
R1489 |
T2467 |
T2466 |
punct |
“,termed |
R1490 |
T2468 |
T2469 |
compound |
GluR,BΔECS |
R1491 |
T2469 |
T2466 |
oprd |
BΔECS,termed |
R1492 |
T2470 |
T2469 |
punct |
-,BΔECS |
R1493 |
T2471 |
T2469 |
punct |
:,BΔECS |
R1494 |
T2472 |
T2469 |
appos |
FB,BΔECS |
R1495 |
T2473 |
T2463 |
punct |
”,1A |
R1496 |
T2474 |
T2463 |
punct |
;,1A |
R1497 |
T2475 |
T2463 |
advcl |
see,1A |
R1498 |
T2476 |
T2475 |
advmod |
also,see |
R1499 |
T2477 |
T2475 |
punct |
[,see |
R1500 |
T2478 |
T2475 |
dobj |
58,see |
R1501 |
T2479 |
T2463 |
punct |
],1A |
R1502 |
T2480 |
T2463 |
punct |
),1A |
R1503 |
T2481 |
T2421 |
punct |
.,analyzed |
R1504 |
T2483 |
T2484 |
det |
These,mice |
R1505 |
T2484 |
T2485 |
nsubj |
mice,carry |
R1506 |
T2486 |
T2485 |
punct |
", ",carry |
R1507 |
T2487 |
T2485 |
prep |
in,carry |
R1508 |
T2488 |
T2487 |
pobj |
addition,in |
R1509 |
T2489 |
T2488 |
prep |
to,addition |
R1510 |
T2490 |
T2491 |
det |
a,allele |
R1511 |
T2491 |
T2489 |
pobj |
allele,to |
R1512 |
T2492 |
T2493 |
amod |
wild,type |
R1513 |
T2493 |
T2491 |
compound |
type,allele |
R1514 |
T2494 |
T2493 |
punct |
-,type |
R1515 |
T2495 |
T2496 |
compound |
GluR,B |
R1516 |
T2496 |
T2491 |
compound |
B,allele |
R1517 |
T2497 |
T2496 |
punct |
-,B |
R1518 |
T2498 |
T2485 |
punct |
", ",carry |
R1519 |
T2499 |
T2500 |
det |
a,allele |
R1520 |
T2500 |
T2485 |
dobj |
allele,carry |
R1521 |
T2501 |
T2502 |
npadvmod |
gene,targeted |
R1522 |
T2502 |
T2500 |
amod |
targeted,allele |
R1523 |
T2503 |
T2502 |
punct |
-,targeted |
R1524 |
T2504 |
T2505 |
compound |
GluR,Bneo |
R1525 |
T2505 |
T2500 |
compound |
Bneo,allele |
R1526 |
T2506 |
T2505 |
punct |
-,Bneo |
R1527 |
T2507 |
T2508 |
prep |
in,replaced |
R1528 |
T2508 |
T2500 |
relcl |
replaced,allele |
R1529 |
T2509 |
T2507 |
pobj |
which,in |
R1530 |
T2510 |
T2511 |
det |
the,sequence |
R1531 |
T2511 |
T2508 |
nsubjpass |
sequence,replaced |
R1532 |
T2512 |
T2511 |
amod |
intronic,sequence |
R1533 |
T2513 |
T2511 |
amod |
critical,sequence |
R1534 |
T2514 |
T2513 |
prep |
for,critical |
R1535 |
T2515 |
T2516 |
compound |
GluR,B |
R1536 |
T2516 |
T2518 |
compound |
B,editing |
R1537 |
T2517 |
T2516 |
punct |
-,B |
R1538 |
T2518 |
T2514 |
pobj |
editing,for |
R1539 |
T2519 |
T2518 |
compound |
pre-mRNA,editing |
R1540 |
T2520 |
T2518 |
prep |
at,editing |
R1541 |
T2521 |
T2522 |
det |
the,site |
R1542 |
T2522 |
T2520 |
pobj |
site,at |
R1543 |
T2523 |
T2524 |
compound |
Q,R |
R1544 |
T2524 |
T2522 |
compound |
R,site |
R1545 |
T2525 |
T2524 |
punct |
/,R |
R1546 |
T2526 |
T2508 |
auxpass |
is,replaced |
R1547 |
T2527 |
T2508 |
agent |
by,replaced |
R1548 |
T2528 |
T2529 |
det |
a,gene |
R1550 |
T2530 |
T2529 |
amod |
floxed,gene |
R1551 |
T2531 |
T2532 |
compound |
TK,neo |
R1552 |
T2532 |
T2529 |
compound |
neo,gene |
R1553 |
T2533 |
T2532 |
punct |
-,neo |
R1554 |
T2534 |
T2529 |
punct |
", ",gene |
R1555 |
T2535 |
T2536 |
dep |
which,reduces |
R1556 |
T2536 |
T2529 |
relcl |
reduces,gene |
R1557 |
T2537 |
T2536 |
advmod |
severely,reduces |
R1558 |
T2538 |
T2536 |
dobj |
splicing,reduces |
R1559 |
T2539 |
T2538 |
prep |
of,splicing |
R1560 |
T2540 |
T2541 |
det |
the,intron |
R1561 |
T2541 |
T2539 |
pobj |
intron,of |
R1562 |
T2542 |
T2541 |
amod |
modified,intron |
R1563 |
T2543 |
T2536 |
cc |
and,reduces |
R1564 |
T2544 |
T2545 |
advmod |
hence,attenuates |
R1565 |
T2545 |
T2536 |
conj |
attenuates,reduces |
R1566 |
T2546 |
T2547 |
det |
the,expression |
R1567 |
T2547 |
T2545 |
dobj |
expression,attenuates |
R1568 |
T2548 |
T2547 |
prep |
of,expression |
R1569 |
T2549 |
T2550 |
det |
the,allele |
R1570 |
T2550 |
T2548 |
pobj |
allele,of |
R1571 |
T2551 |
T2552 |
compound |
GluR,Bneo |
R1572 |
T2552 |
T2550 |
compound |
Bneo,allele |
R1573 |
T2553 |
T2552 |
punct |
-,Bneo |
R1574 |
T2554 |
T2555 |
punct |
[,60 |
R1575 |
T2555 |
T2485 |
parataxis |
60,carry |
R1576 |
T2556 |
T2555 |
punct |
],60 |
R1577 |
T2557 |
T2485 |
punct |
.,carry |
R1578 |
T2559 |
T2560 |
aux |
To,unsilence |
R1579 |
T2560 |
T2561 |
advcl |
unsilence,crossed |
R1580 |
T2562 |
T2563 |
det |
the,allele |
R1582 |
T2564 |
T2563 |
amod |
attenuated,allele |
R1583 |
T2565 |
T2566 |
compound |
GluR,Bneo |
R1584 |
T2566 |
T2563 |
compound |
Bneo,allele |
R1585 |
T2567 |
T2566 |
punct |
-,Bneo |
R1586 |
T2568 |
T2560 |
punct |
", ",unsilence |
R1587 |
T2569 |
T2570 |
advmod |
specifically,in |
R1588 |
T2570 |
T2560 |
prep |
in,unsilence |
R1589 |
T2571 |
T2572 |
det |
the,forebrain |
R1590 |
T2572 |
T2570 |
pobj |
forebrain,in |
R1591 |
T2573 |
T2572 |
amod |
postnatal,forebrain |
R1592 |
T2574 |
T2561 |
punct |
", ",crossed |
R1593 |
T2575 |
T2561 |
nsubj |
we,crossed |
R1594 |
T2576 |
T2561 |
prep |
in,crossed |
R1595 |
T2577 |
T2578 |
det |
the,transgene |
R1596 |
T2578 |
T2576 |
pobj |
transgene,in |
R1597 |
T2579 |
T2578 |
compound |
TgCre4,transgene |
R1598 |
T2580 |
T2578 |
punct |
", ",transgene |
R1599 |
T2581 |
T2582 |
dep |
which,encodes |
R1600 |
T2582 |
T2578 |
relcl |
encodes,transgene |
R1601 |
T2583 |
T2584 |
compound |
Cre,recombinase |
R1602 |
T2584 |
T2582 |
dobj |
recombinase,encodes |
R1603 |
T2585 |
T2584 |
punct |
-,recombinase |
R1604 |
T2586 |
T2582 |
cc |
and,encodes |
R1605 |
T2587 |
T2588 |
auxpass |
is,driven |
R1606 |
T2588 |
T2582 |
conj |
driven,encodes |
R1607 |
T2589 |
T2588 |
agent |
by,driven |
R1608 |
T2590 |
T2591 |
det |
the,promoter |
R1609 |
T2591 |
T2589 |
pobj |
promoter,by |
R1610 |
T2592 |
T2591 |
compound |
αCaMKII,promoter |
R1611 |
T2593 |
T2594 |
punct |
(,Camkcre4 |
R1612 |
T2594 |
T2561 |
parataxis |
Camkcre4,crossed |
R1613 |
T2595 |
T2594 |
punct |
[,Camkcre4 |
R1614 |
T2596 |
T2594 |
dep |
59,Camkcre4 |
R1615 |
T2597 |
T2594 |
punct |
],Camkcre4 |
R1616 |
T2598 |
T2594 |
punct |
;,Camkcre4 |
R1617 |
T2599 |
T2594 |
punct |
“,Camkcre4 |
R1618 |
T2600 |
T2594 |
punct |
”,Camkcre4 |
R1619 |
T2601 |
T2594 |
punct |
),Camkcre4 |
R1620 |
T2602 |
T2561 |
punct |
.,crossed |
R1621 |
T2604 |
T2605 |
advmod |
Thus,removes |
R1622 |
T2606 |
T2605 |
punct |
", ",removes |
R1623 |
T2607 |
T2608 |
compound |
Cre,recombinase |
R1624 |
T2608 |
T2605 |
nsubj |
recombinase,removes |
R1625 |
T2609 |
T2608 |
punct |
-,recombinase |
R1626 |
T2610 |
T2605 |
prep |
in,removes |
R1627 |
T2611 |
T2612 |
compound |
forebrain,neurons |
R1628 |
T2612 |
T2610 |
pobj |
neurons,in |
R1629 |
T2613 |
T2614 |
det |
the,gene |
R1631 |
T2615 |
T2614 |
amod |
intronic,gene |
R1632 |
T2616 |
T2617 |
compound |
TK,neo |
R1633 |
T2617 |
T2614 |
compound |
neo,gene |
R1634 |
T2618 |
T2617 |
punct |
-,neo |
R1635 |
T2619 |
T2605 |
punct |
", ",removes |
R1636 |
T2620 |
T2605 |
advcl |
leading,removes |
R1637 |
T2621 |
T2620 |
prep |
to,leading |
R1638 |
T2622 |
T2623 |
det |
the,allele |
R1640 |
T2624 |
T2623 |
amod |
active,allele |
R1641 |
T2625 |
T2626 |
compound |
GluR,BΔECS |
R1642 |
T2626 |
T2623 |
compound |
BΔECS,allele |
R1643 |
T2627 |
T2626 |
punct |
-,BΔECS |
R1644 |
T2628 |
T2623 |
prep |
for,allele |
R1645 |
T2629 |
T2630 |
compound |
Q,R |
R1646 |
T2630 |
T2632 |
compound |
R,site |
R1647 |
T2631 |
T2630 |
punct |
/,R |
R1648 |
T2632 |
T2633 |
npadvmod |
site,unedited |
R1649 |
T2633 |
T2635 |
amod |
unedited,subunits |
R1650 |
T2634 |
T2633 |
punct |
-,unedited |
R1651 |
T2635 |
T2628 |
pobj |
subunits,for |
R1652 |
T2636 |
T2637 |
nmod |
GluR,B |
R1653 |
T2637 |
T2635 |
nmod |
B,subunits |
R1654 |
T2638 |
T2637 |
punct |
-,B |
R1655 |
T2639 |
T2640 |
punct |
(,Q |
R1656 |
T2640 |
T2635 |
parataxis |
Q,subunits |
R1657 |
T2641 |
T2640 |
punct |
),Q |
R1658 |
T2642 |
T2643 |
punct |
(,S1 |
R1659 |
T2643 |
T2605 |
parataxis |
S1,removes |
R1660 |
T2644 |
T2643 |
dep |
Figures,S1 |
R1661 |
T2645 |
T2643 |
nummod |
1,S1 |
R1662 |
T2646 |
T2643 |
cc |
and,S1 |
R1663 |
T2647 |
T2643 |
punct |
),S1 |
R1664 |
T2648 |
T2605 |
punct |
.,removes |
R1665 |
T2650 |
T2651 |
mark |
As,expected |
R1666 |
T2651 |
T2652 |
advcl |
expected,increased |
R1667 |
T2653 |
T2654 |
punct |
[,60 |
R1668 |
T2654 |
T2651 |
parataxis |
60,expected |
R1669 |
T2655 |
T2654 |
nummod |
53,60 |
R1670 |
T2656 |
T2654 |
punct |
",",60 |
R1671 |
T2657 |
T2654 |
punct |
],60 |
R1672 |
T2658 |
T2652 |
punct |
", ",increased |
R1673 |
T2659 |
T2660 |
advmod |
also,in |
R1674 |
T2660 |
T2652 |
prep |
in,increased |
R1675 |
T2661 |
T2660 |
pobj |
mice,in |
R1676 |
T2662 |
T2661 |
acl |
expressing,mice |
R1677 |
T2663 |
T2662 |
advmod |
postnatally,expressing |
R1678 |
T2664 |
T2665 |
npadvmod |
forebrain,specific |
R1679 |
T2665 |
T2667 |
amod |
specific,subunits |
R1680 |
T2666 |
T2665 |
punct |
-,specific |
R1681 |
T2667 |
T2662 |
dobj |
subunits,expressing |
R1682 |
T2668 |
T2669 |
compound |
Q,R |
R1683 |
T2669 |
T2671 |
compound |
R,site |
R1684 |
T2670 |
T2669 |
punct |
/,R |
R1685 |
T2671 |
T2672 |
npadvmod |
site,unedited |
R1686 |
T2672 |
T2667 |
amod |
unedited,subunits |
R1687 |
T2673 |
T2672 |
punct |
-,unedited |
R1688 |
T2674 |
T2675 |
nmod |
GluR,B |
R1689 |
T2675 |
T2667 |
nmod |
B,subunits |
R1690 |
T2676 |
T2675 |
punct |
-,B |
R1691 |
T2677 |
T2678 |
punct |
(,Q |
R1692 |
T2678 |
T2667 |
parataxis |
Q,subunits |
R1693 |
T2679 |
T2678 |
punct |
),Q |
R1694 |
T2680 |
T2652 |
punct |
", ",increased |
R1695 |
T2681 |
T2682 |
nmod |
Ca2,permeability |
R1696 |
T2682 |
T2652 |
nsubjpass |
permeability,increased |
R1697 |
T2683 |
T2681 |
punct |
+,Ca2 |
R1698 |
T2684 |
T2682 |
prep |
through,permeability |
R1699 |
T2685 |
T2684 |
pobj |
AMPAR,through |
R1700 |
T2686 |
T2652 |
auxpass |
was,increased |
R1701 |
T2687 |
T2652 |
cc |
and,increased |
R1702 |
T2688 |
T2689 |
compound |
AMPAR,currents |
R1703 |
T2689 |
T2690 |
nsubj |
currents,showed |
R1704 |
T2690 |
T2652 |
conj |
showed,increased |
R1705 |
T2691 |
T2690 |
dobj |
rectification,showed |
R1706 |
T2692 |
T2693 |
punct |
(,58 |
R1707 |
T2693 |
T2690 |
parataxis |
58,showed |
R1708 |
T2694 |
T2693 |
punct |
[,58 |
R1709 |
T2695 |
T2693 |
punct |
],58 |
R1710 |
T2696 |
T2693 |
cc |
and,58 |
R1711 |
T2697 |
T2698 |
amod |
unpublished,data |
R1712 |
T2698 |
T2693 |
conj |
data,58 |
R1713 |
T2699 |
T2698 |
punct |
),data |
R1714 |
T2700 |
T2652 |
punct |
.,increased |
R1715 |
T2702 |
T2703 |
nmod |
GluR,BΔECS |
R1716 |
T2703 |
T2705 |
nmod |
BΔECS,mice |
R1717 |
T2704 |
T2703 |
punct |
-,BΔECS |
R1718 |
T2705 |
T2708 |
nsubj |
mice,had |
R1719 |
T2706 |
T2703 |
punct |
:,BΔECS |
R1720 |
T2707 |
T2703 |
appos |
FB,BΔECS |
R1721 |
T2709 |
T2708 |
punct |
", ",had |
R1722 |
T2710 |
T2708 |
prep |
in,had |
R1723 |
T2711 |
T2710 |
pobj |
contrast,in |
R1724 |
T2712 |
T2711 |
prep |
to,contrast |
R1725 |
T2713 |
T2712 |
pobj |
mice,to |
R1726 |
T2714 |
T2713 |
acl |
expressing,mice |
R1727 |
T2715 |
T2716 |
nmod |
GluR,Q |
R1728 |
T2716 |
T2714 |
dobj |
Q,expressing |
R1729 |
T2717 |
T2716 |
punct |
-,Q |
R1730 |
T2718 |
T2716 |
nmod |
B,Q |
R1731 |
T2719 |
T2716 |
punct |
(,Q |
R1732 |
T2720 |
T2716 |
punct |
),Q |
R1733 |
T2721 |
T2714 |
advmod |
globally,expressing |
R1734 |
T2722 |
T2708 |
punct |
", ",had |
R1735 |
T2723 |
T2724 |
det |
a,lifespan |
R1736 |
T2724 |
T2708 |
dobj |
lifespan,had |
R1737 |
T2725 |
T2724 |
amod |
prolonged,lifespan |
R1738 |
T2726 |
T2724 |
cc |
and,lifespan |
R1739 |
T2727 |
T2728 |
det |
no,alterations |
R1740 |
T2728 |
T2724 |
conj |
alterations,lifespan |
R1741 |
T2729 |
T2728 |
amod |
severe,alterations |
R1742 |
T2730 |
T2728 |
amod |
developmental,alterations |
R1743 |
T2731 |
T2708 |
punct |
.,had |
R1744 |
T2733 |
T2734 |
nsubj |
They,were |
R1745 |
T2735 |
T2734 |
advmod |
however,were |
R1746 |
T2736 |
T2734 |
punct |
", ",were |
R1747 |
T2737 |
T2734 |
advmod |
still,were |
R1748 |
T2738 |
T2739 |
npadvmod |
seizure,prone |
R1749 |
T2739 |
T2734 |
acomp |
prone,were |
R1750 |
T2740 |
T2739 |
punct |
-,prone |
R1751 |
T2741 |
T2742 |
punct |
[,58 |
R1752 |
T2742 |
T2734 |
parataxis |
58,were |
R1753 |
T2743 |
T2742 |
punct |
],58 |
R1754 |
T2744 |
T2734 |
punct |
", ",were |
R1755 |
T2745 |
T2734 |
cc |
and,were |
R1756 |
T2746 |
T2747 |
advmod |
hence,restricted |
R1757 |
T2747 |
T2734 |
conj |
restricted,were |
R1758 |
T2748 |
T2749 |
amod |
behavioral,training |
R1759 |
T2749 |
T2747 |
nsubjpass |
training,restricted |
R1760 |
T2750 |
T2747 |
auxpass |
was,restricted |
R1761 |
T2751 |
T2747 |
prep |
to,restricted |
R1762 |
T2752 |
T2753 |
amod |
short,periods |
R1763 |
T2753 |
T2751 |
pobj |
periods,to |
R1764 |
T2754 |
T2753 |
prep |
of,periods |
R1765 |
T2755 |
T2754 |
pobj |
time,of |
R1766 |
T2756 |
T2747 |
punct |
.,restricted |
R1767 |
T2758 |
T2759 |
nsubj |
We,trained |
R1768 |
T2760 |
T2761 |
nummod |
six,mice |
R1769 |
T2761 |
T2759 |
dobj |
mice,trained |
R1770 |
T2762 |
T2763 |
nmod |
GluR,BΔECS |
R1771 |
T2763 |
T2761 |
nmod |
BΔECS,mice |
R1772 |
T2764 |
T2763 |
punct |
-,BΔECS |
R1773 |
T2765 |
T2763 |
punct |
:,BΔECS |
R1774 |
T2766 |
T2763 |
appos |
FB,BΔECS |
R1775 |
T2767 |
T2761 |
cc |
and,mice |
R1776 |
T2768 |
T2769 |
nummod |
six,controls |
R1777 |
T2769 |
T2761 |
conj |
controls,mice |
R1778 |
T2770 |
T2769 |
compound |
littermate,controls |
R1779 |
T2771 |
T2759 |
prep |
on,trained |
R1780 |
T2772 |
T2773 |
nummod |
one,pair |
R1781 |
T2773 |
T2771 |
pobj |
pair,on |
R1782 |
T2774 |
T2773 |
compound |
odor,pair |
R1783 |
T2775 |
T2759 |
prep |
in,trained |
R1784 |
T2776 |
T2777 |
det |
an,task |
R1785 |
T2777 |
T2775 |
pobj |
task,in |
R1786 |
T2778 |
T2777 |
amod |
automated,task |
R1787 |
T2779 |
T2777 |
nmod |
go,task |
R1788 |
T2780 |
T2779 |
punct |
/,go |
R1789 |
T2781 |
T2782 |
det |
no,go |
R1790 |
T2782 |
T2779 |
appos |
go,go |
R1791 |
T2783 |
T2782 |
punct |
-,go |
R1792 |
T2784 |
T2785 |
amod |
olfactory,conditioning |
R1793 |
T2785 |
T2777 |
compound |
conditioning,task |
R1794 |
T2786 |
T2787 |
punct |
[,61 |
R1795 |
T2787 |
T2759 |
parataxis |
61,trained |
R1796 |
T2788 |
T2787 |
nummod |
3,61 |
R1797 |
T2789 |
T2787 |
punct |
",",61 |
R1798 |
T2790 |
T2787 |
punct |
],61 |
R1799 |
T2791 |
T2759 |
punct |
.,trained |
R1800 |
T2793 |
T2794 |
prep |
In,trained |
R1801 |
T2795 |
T2796 |
det |
this,task |
R1802 |
T2796 |
T2793 |
pobj |
task,In |
R1803 |
T2797 |
T2794 |
punct |
", ",trained |
R1804 |
T2798 |
T2799 |
npadvmod |
water,deprived |
R1805 |
T2799 |
T2801 |
amod |
deprived,mice |
R1806 |
T2800 |
T2799 |
punct |
-,deprived |
R1807 |
T2801 |
T2794 |
nsubjpass |
mice,trained |
R1808 |
T2802 |
T2794 |
auxpass |
are,trained |
R1809 |
T2803 |
T2804 |
aux |
to,distinguish |
R1810 |
T2804 |
T2794 |
xcomp |
distinguish,trained |
R1811 |
T2805 |
T2806 |
det |
a,odor |
R1812 |
T2806 |
T2804 |
dobj |
odor,distinguish |
R1813 |
T2807 |
T2808 |
npadvmod |
water,rewarded |
R1814 |
T2808 |
T2806 |
amod |
rewarded,odor |
R1815 |
T2809 |
T2808 |
punct |
-,rewarded |
R1816 |
T2810 |
T2811 |
punct |
(,S |
R1817 |
T2811 |
T2806 |
parataxis |
S,odor |
R1818 |
T2812 |
T2811 |
punct |
+,S |
R1819 |
T2813 |
T2811 |
punct |
),S |
R1820 |
T2814 |
T2806 |
cc |
and,odor |
R1821 |
T2815 |
T2816 |
det |
an,odor |
R1822 |
T2816 |
T2806 |
conj |
odor,odor |
R1823 |
T2817 |
T2816 |
amod |
unrewarded,odor |
R1824 |
T2818 |
T2819 |
punct |
(,S |
R1825 |
T2819 |
T2816 |
parataxis |
S,odor |
R1826 |
T2820 |
T2819 |
punct |
−,S |
R1827 |
T2821 |
T2819 |
punct |
),S |
R1828 |
T2822 |
T2804 |
prep |
by,distinguish |
R1829 |
T2823 |
T2824 |
poss |
their,response |
R1830 |
T2824 |
T2822 |
pobj |
response,by |
R1831 |
T2825 |
T2824 |
compound |
licking,response |
R1832 |
T2826 |
T2827 |
punct |
(,1B |
R1833 |
T2827 |
T2794 |
parataxis |
1B,trained |
R1834 |
T2828 |
T2827 |
compound |
Figure,1B |
R1835 |
T2829 |
T2827 |
punct |
),1B |
R1836 |
T2830 |
T2794 |
punct |
.,trained |
R1837 |
T2832 |
T2833 |
preconj |
Both,BΔECS |
R1838 |
T2833 |
T2836 |
nsubj |
BΔECS,acquired |
R1839 |
T2834 |
T2833 |
compound |
GluR,BΔECS |
R1840 |
T2835 |
T2833 |
punct |
-,BΔECS |
R1841 |
T2837 |
T2833 |
punct |
:,BΔECS |
R1842 |
T2838 |
T2833 |
appos |
FB,BΔECS |
R1843 |
T2839 |
T2833 |
cc |
and,BΔECS |
R1844 |
T2840 |
T2841 |
compound |
control,mice |
R1845 |
T2841 |
T2833 |
conj |
mice,BΔECS |
R1846 |
T2842 |
T2843 |
det |
the,task |
R1847 |
T2843 |
T2836 |
dobj |
task,acquired |
R1848 |
T2844 |
T2843 |
punct |
“,task |
R1849 |
T2845 |
T2843 |
amod |
simple,task |
R1850 |
T2846 |
T2843 |
punct |
”,task |
R1851 |
T2847 |
T2848 |
aux |
to,discriminate |
R1852 |
T2848 |
T2843 |
acl |
discriminate,task |
R1853 |
T2849 |
T2848 |
prep |
between,discriminate |
R1854 |
T2850 |
T2851 |
det |
the,odors |
R1855 |
T2851 |
T2849 |
pobj |
odors,between |
R1856 |
T2852 |
T2851 |
amod |
monomolecular,odors |
R1857 |
T2853 |
T2851 |
appos |
amylacetate,odors |
R1858 |
T2854 |
T2853 |
cc |
and,amylacetate |
R1859 |
T2855 |
T2853 |
conj |
ethylbutyrate,amylacetate |
R1860 |
T2856 |
T2857 |
punct |
(,% |
R1862 |
T2858 |
T2857 |
nsubj |
percentage,% |
R1863 |
T2859 |
T2858 |
amod |
correct,percentage |
R1864 |
T2860 |
T2857 |
punct |
>,% |
R1865 |
T2861 |
T2857 |
nummod |
70,% |
R1866 |
T2862 |
T2857 |
prep |
after,% |
R1867 |
T2863 |
T2864 |
nummod |
400,trials |
R1868 |
T2864 |
T2862 |
pobj |
trials,after |
R1869 |
T2865 |
T2857 |
punct |
),% |
R1870 |
T2866 |
T2836 |
punct |
.,acquired |
R1871 |
T2868 |
T2869 |
advmod |
Strikingly,showed |
R1872 |
T2870 |
T2869 |
punct |
", ",showed |
R1873 |
T2871 |
T2872 |
nmod |
GluR,BΔECS |
R1874 |
T2872 |
T2874 |
nmod |
BΔECS,mice |
R1875 |
T2873 |
T2872 |
punct |
-,BΔECS |
R1876 |
T2874 |
T2869 |
nsubj |
mice,showed |
R1877 |
T2875 |
T2872 |
punct |
:,BΔECS |
R1878 |
T2876 |
T2872 |
appos |
FB,BΔECS |
R1879 |
T2877 |
T2878 |
advmod |
more,rapid |
R1880 |
T2878 |
T2879 |
amod |
rapid,learning |
R1881 |
T2879 |
T2869 |
dobj |
learning,showed |
R1882 |
T2880 |
T2879 |
cc |
and,learning |
R1883 |
T2881 |
T2882 |
amod |
enhanced,capabilities |
R1884 |
T2882 |
T2879 |
conj |
capabilities,learning |
R1885 |
T2883 |
T2882 |
compound |
discrimination,capabilities |
R1886 |
T2884 |
T2885 |
punct |
(,1C |
R1887 |
T2885 |
T2869 |
parataxis |
1C,showed |
R1888 |
T2886 |
T2885 |
compound |
Figure,1C |
R1889 |
T2887 |
T2885 |
punct |
", ",1C |
R1890 |
T2888 |
T2889 |
compound |
group,effect |
R1891 |
T2889 |
T2890 |
dep |
effect,0.01 |
R1892 |
T2890 |
T2885 |
dep |
0.01,1C |
R1893 |
T2891 |
T2890 |
punct |
: ,0.01 |
R1894 |
T2892 |
T2893 |
nsubj |
F,10.2 |
R1895 |
T2893 |
T2890 |
ccomp |
10.2,0.01 |
R1896 |
T2894 |
T2892 |
punct |
(,F |
R1897 |
T2895 |
T2892 |
nummod |
1,F |
R1898 |
T2896 |
T2892 |
punct |
",",F |
R1899 |
T2897 |
T2892 |
nummod |
10,F |
R1900 |
T2898 |
T2892 |
punct |
),F |
R1901 |
T2899 |
T2893 |
punct |
=,10.2 |
R1902 |
T2900 |
T2890 |
punct |
", ",0.01 |
R1903 |
T2901 |
T2890 |
nsubj |
p,0.01 |
R1904 |
T2902 |
T2890 |
punct |
<,0.01 |
R1905 |
T2903 |
T2885 |
punct |
),1C |
R1906 |
T2904 |
T2869 |
punct |
.,showed |
R1907 |
T2906 |
T2907 |
nsubjpass |
This,confirmed |
R1908 |
T2908 |
T2907 |
auxpass |
was,confirmed |
R1909 |
T2909 |
T2907 |
prep |
by,confirmed |
R1910 |
T2910 |
T2909 |
pcomp |
fitting,by |
R1911 |
T2911 |
T2912 |
amod |
linear,lines |
R1912 |
T2912 |
T2910 |
dobj |
lines,fitting |
R1913 |
T2913 |
T2912 |
compound |
trend,lines |
R1914 |
T2914 |
T2910 |
prep |
to,fitting |
R1915 |
T2915 |
T2916 |
det |
the,part |
R1916 |
T2916 |
T2914 |
pobj |
part,to |
R1917 |
T2917 |
T2916 |
amod |
initial,part |
R1918 |
T2918 |
T2916 |
prep |
of,part |
R1919 |
T2919 |
T2920 |
det |
the,curve |
R1920 |
T2920 |
T2918 |
pobj |
curve,of |
R1921 |
T2921 |
T2920 |
compound |
learning,curve |
R1922 |
T2922 |
T2923 |
punct |
(,see |
R1923 |
T2923 |
T2907 |
parataxis |
see,confirmed |
R1924 |
T2924 |
T2925 |
compound |
slope,difference |
R1925 |
T2925 |
T2926 |
dep |
difference,p |
R1926 |
T2926 |
T2923 |
dep |
p,see |
R1927 |
T2927 |
T2926 |
punct |
: ,p |
R1928 |
T2928 |
T2929 |
punct |
<,0.05 |
R1929 |
T2929 |
T2926 |
prep |
0.05,p |
R1930 |
T2930 |
T2923 |
punct |
;,see |
R1931 |
T2931 |
T2923 |
dobj |
Materials,see |
R1932 |
T2932 |
T2931 |
cc |
and,Materials |
R1933 |
T2933 |
T2931 |
conj |
Methods,Materials |
R1934 |
T2934 |
T2923 |
punct |
),see |
R1935 |
T2935 |
T2907 |
punct |
.,confirmed |
R1936 |
T2937 |
T2938 |
det |
The,system |
R1937 |
T2938 |
T2940 |
nsubj |
system,allows |
R1938 |
T2939 |
T2938 |
compound |
training,system |
R1939 |
T2941 |
T2938 |
acl |
employed,system |
R1940 |
T2942 |
T2940 |
prep |
for,allows |
R1941 |
T2943 |
T2944 |
amod |
careful,monitoring |
R1942 |
T2944 |
T2942 |
pobj |
monitoring,for |
R1943 |
T2945 |
T2944 |
prep |
of,monitoring |
R1944 |
T2946 |
T2947 |
compound |
head,positions |
R1945 |
T2947 |
T2945 |
pobj |
positions,of |
R1946 |
T2948 |
T2949 |
punct |
[,3 |
R1947 |
T2949 |
T2940 |
parataxis |
3,allows |
R1948 |
T2950 |
T2949 |
punct |
],3 |
R1949 |
T2951 |
T2940 |
punct |
.,allows |
R1950 |
T2953 |
T2954 |
prep |
For,kept |
R1951 |
T2955 |
T2956 |
amod |
rewarded,trials |
R1952 |
T2956 |
T2953 |
pobj |
trials,For |
R1953 |
T2957 |
T2958 |
punct |
(,1D |
R1954 |
T2958 |
T2956 |
parataxis |
1D,trials |
R1955 |
T2959 |
T2958 |
compound |
Figure,1D |
R1956 |
T2960 |
T2958 |
punct |
", ",1D |
R1957 |
T2961 |
T2958 |
amod |
green,1D |
R1958 |
T2962 |
T2958 |
punct |
),1D |
R1959 |
T2963 |
T2954 |
punct |
", ",kept |
R1960 |
T2964 |
T2965 |
advmod |
already,trained |
R1961 |
T2965 |
T2967 |
amod |
trained,animals |
R1962 |
T2966 |
T2965 |
advmod |
weakly,trained |
R1963 |
T2967 |
T2954 |
nsubj |
animals,kept |
R1964 |
T2968 |
T2969 |
poss |
their,head |
R1965 |
T2969 |
T2954 |
dobj |
head,kept |
R1966 |
T2970 |
T2954 |
oprd |
in,kept |
R1967 |
T2971 |
T2972 |
det |
the,port |
R1968 |
T2972 |
T2970 |
pobj |
port,in |
R1969 |
T2973 |
T2972 |
compound |
sampling,port |
R1970 |
T2974 |
T2975 |
punct |
(,tube |
R1971 |
T2975 |
T2972 |
parataxis |
tube,port |
R1972 |
T2976 |
T2975 |
amod |
large,tube |
R1973 |
T2977 |
T2975 |
prep |
in,tube |
R1974 |
T2978 |
T2979 |
compound |
Figure,1B |
R1975 |
T2979 |
T2977 |
pobj |
1B,in |
R1976 |
T2980 |
T2975 |
punct |
),tube |
R1977 |
T2981 |
T2954 |
prep |
during,kept |
R1978 |
T2982 |
T2983 |
det |
the,trial |
R1980 |
T2984 |
T2983 |
amod |
entire,trial |
R1981 |
T2985 |
T2986 |
nummod |
2,s |
R1982 |
T2986 |
T2983 |
compound |
s,trial |
R1983 |
T2987 |
T2986 |
punct |
-,s |
R1984 |
T2988 |
T2954 |
punct |
", ",kept |
R1985 |
T2989 |
T2990 |
mark |
whereas,retracted |
R1986 |
T2990 |
T2954 |
advcl |
retracted,kept |
R1987 |
T2991 |
T2990 |
prep |
for,retracted |
R1988 |
T2992 |
T2993 |
amod |
unrewarded,trials |
R1989 |
T2993 |
T2991 |
pobj |
trials,for |
R1990 |
T2994 |
T2995 |
det |
the,head |
R1991 |
T2995 |
T2990 |
nsubjpass |
head,retracted |
R1992 |
T2996 |
T2990 |
auxpass |
is,retracted |
R1993 |
T2997 |
T2990 |
advmod |
quickly,retracted |
R1994 |
T2998 |
T2999 |
punct |
(,1D |
R1995 |
T2999 |
T2954 |
parataxis |
1D,kept |
R1996 |
T3001 |
T2999 |
punct |
", ",1D |
R1997 |
T3002 |
T2999 |
amod |
red,1D |
R1998 |
T3003 |
T2999 |
punct |
),1D |
R1999 |
T3004 |
T2954 |
punct |
.,kept |
R2000 |
T3006 |
T3007 |
det |
The,difference |
R2001 |
T3007 |
T3008 |
nsubj |
difference,is |
R2002 |
T3008 |
T3019 |
ccomp |
is,referred |
R2003 |
T3009 |
T3007 |
prep |
of,difference |
R2004 |
T3010 |
T3011 |
det |
these,curves |
R2005 |
T3000 |
T2999 |
compound |
Figure,1D |
R2006 |
T3012 |
T3011 |
nummod |
two,curves |
R2007 |
T3013 |
T3014 |
punct |
(,1E |
R2008 |
T3011 |
T3009 |
pobj |
curves,of |
R2009 |
T3015 |
T3014 |
compound |
Figure,1E |
R2010 |
T3014 |
T3007 |
parataxis |
1E,difference |
R2011 |
T3017 |
T3014 |
amod |
black,1E |
R2012 |
T3016 |
T3014 |
punct |
", ",1E |
R2013 |
T3020 |
T3021 |
det |
a,assay |
R2014 |
T3021 |
T3008 |
attr |
assay,is |
R2015 |
T3018 |
T3014 |
punct |
),1E |
R2016 |
T3023 |
T3021 |
amod |
sensitive,assay |
R2017 |
T3022 |
T3023 |
advmod |
very,sensitive |
R2018 |
T3025 |
T3026 |
compound |
discrimination,performance |
R2019 |
T3026 |
T3024 |
pobj |
performance,for |
R2020 |
T3024 |
T3008 |
prep |
for,is |
R2021 |
T3028 |
T3029 |
det |
the,maximum |
R2022 |
T3029 |
T3019 |
nsubjpass |
maximum,referred |
R2023 |
T3027 |
T3019 |
punct |
;,referred |
R2024 |
T3031 |
T3029 |
prep |
of,maximum |
R2025 |
T3030 |
T3029 |
amod |
fitted,maximum |
R2026 |
T3033 |
T3031 |
pobj |
curve,of |
R2027 |
T3034 |
T3035 |
punct |
(,1E |
R2028 |
T3032 |
T3033 |
det |
this,curve |
R2029 |
T3036 |
T3035 |
compound |
Figure,1E |
R2030 |
T3037 |
T3035 |
punct |
", ",1E |
R2031 |
T3035 |
T3029 |
parataxis |
1E,maximum |
R2032 |
T3039 |
T3035 |
punct |
),1E |
R2033 |
T3040 |
T3019 |
auxpass |
is,referred |
R2034 |
T3041 |
T3019 |
prep |
to,referred |
R2035 |
T3038 |
T3035 |
amod |
blue,1E |
R2036 |
T3043 |
T3044 |
det |
the,index |
R2037 |
T3042 |
T3019 |
prep |
as,referred |
R2038 |
T3045 |
T3044 |
punct |
“,index |
R2039 |
T3046 |
T3044 |
compound |
discrimination,index |
R2040 |
T3044 |
T3042 |
pobj |
index,as |
R2041 |
T3048 |
T3019 |
prep |
in,referred |
R2042 |
T3049 |
T3050 |
det |
the,remainder |
R2043 |
T3050 |
T3048 |
pobj |
remainder,in |
R2044 |
T3047 |
T3019 |
punct |
”,referred |
R2045 |
T3052 |
T3053 |
det |
the,paper |
R2046 |
T3051 |
T3050 |
prep |
of,remainder |
R2047 |
T3054 |
T3019 |
cc |
and,referred |
R2048 |
T3055 |
T3056 |
auxpass |
is,improved |
R2049 |
T3053 |
T3051 |
pobj |
paper,of |
R2050 |
T3057 |
T3056 |
advmod |
again,improved |
R2051 |
T3056 |
T3019 |
conj |
improved,referred |
R2052 |
T3059 |
T3056 |
prep |
for,improved |
R2053 |
T3060 |
T3061 |
nmod |
GluR,BΔECS |
R2054 |
T3058 |
T3056 |
advmod |
strongly,improved |
R2055 |
T3062 |
T3061 |
punct |
-,BΔECS |
R2056 |
T3061 |
T3063 |
nmod |
BΔECS,mice |
R2057 |
T3064 |
T3061 |
punct |
:,BΔECS |
R2058 |
T3063 |
T3059 |
pobj |
mice,for |
R2059 |
T3066 |
T3056 |
punct |
", ",improved |
R2060 |
T3067 |
T3056 |
prep |
compared,improved |
R2061 |
T3065 |
T3061 |
appos |
FB,BΔECS |
R2062 |
T3069 |
T3068 |
pobj |
controls,with |
R2063 |
T3068 |
T3067 |
prep |
with,compared |
R2064 |
T3071 |
T3056 |
parataxis |
1F,improved |
R2065 |
T3072 |
T3071 |
compound |
Figure,1F |
R2066 |
T3073 |
T3071 |
punct |
;,1F |
R2067 |
T3070 |
T3071 |
punct |
(,1F |
R2068 |
T3075 |
T3076 |
dep |
effect,0.01 |
R2069 |
T3074 |
T3075 |
compound |
group,effect |
R2070 |
T3077 |
T3076 |
punct |
: ,0.01 |
R2071 |
T3078 |
T3079 |
nsubj |
F,11.7 |
R2072 |
T3076 |
T3071 |
dep |
0.01,1F |
R2073 |
T3080 |
T3078 |
punct |
(,F |
R2074 |
T3081 |
T3078 |
nummod |
1,F |
R2075 |
T3079 |
T3076 |
ccomp |
11.7,0.01 |
R2076 |
T3083 |
T3078 |
nummod |
10,F |
R2077 |
T3084 |
T3078 |
punct |
),F |
R2078 |
T3082 |
T3078 |
punct |
",",F |
R2079 |
T3086 |
T3076 |
punct |
", ",0.01 |
R2080 |
T3085 |
T3079 |
punct |
=,11.7 |
R2081 |
T3088 |
T3076 |
punct |
<,0.01 |
R2082 |
T3087 |
T3076 |
nsubj |
p,0.01 |
R2083 |
T3090 |
T3019 |
punct |
.,referred |
R2084 |
T3092 |
T3093 |
nsubj |
This,was |
R2085 |
T3089 |
T3071 |
punct |
),1F |
R2086 |
T3095 |
T3093 |
prep |
due,was |
R2087 |
T3096 |
T3095 |
pcomp |
to,due |
R2088 |
T3094 |
T3093 |
neg |
not,was |
R2089 |
T3098 |
T3095 |
pobj |
performance,due |
R2090 |
T3097 |
T3098 |
amod |
general,performance |
R2091 |
T3100 |
T3098 |
punct |
", ",performance |
R2092 |
T3102 |
T3101 |
punct |
", ",attention |
R2093 |
T3099 |
T3098 |
compound |
motor,performance |
R2094 |
T3101 |
T3098 |
conj |
attention,performance |
R2095 |
T3104 |
T3105 |
compound |
motivation,changes |
R2096 |
T3105 |
T3101 |
conj |
changes,attention |
R2097 |
T3103 |
T3101 |
cc |
or,attention |
R2098 |
T3107 |
T3108 |
mark |
as,were |
R2099 |
T3106 |
T3093 |
punct |
", ",was |
R2100 |
T3109 |
T3110 |
preconj |
both,interval |
R2101 |
T3108 |
T3093 |
advcl |
were,was |
R2102 |
T3111 |
T3110 |
det |
the,interval |
R2103 |
T3110 |
T3108 |
nsubj |
interval,were |
R2104 |
T3113 |
T3114 |
punct |
(,effect |
R2105 |
T3114 |
T3110 |
parataxis |
effect,interval |
R2106 |
T3115 |
T3114 |
compound |
group,effect |
R2107 |
T3112 |
T3110 |
amod |
intertrial,interval |
R2108 |
T3117 |
T3118 |
nsubj |
F,0.56 |
R2109 |
T3118 |
T3125 |
ccomp |
0.56,0.4 |
R2110 |
T3116 |
T3114 |
punct |
: ,effect |
R2111 |
T3120 |
T3117 |
nummod |
1,F |
R2112 |
T3119 |
T3117 |
punct |
(,F |
R2113 |
T3122 |
T3117 |
nummod |
10,F |
R2114 |
T3123 |
T3117 |
punct |
),F |
R2115 |
T3121 |
T3117 |
punct |
",",F |
R2116 |
T3125 |
T3114 |
ccomp |
0.4,effect |
R2117 |
T3124 |
T3118 |
punct |
=,0.56 |
R2118 |
T3126 |
T3125 |
punct |
", ",0.4 |
R2119 |
T3128 |
T3125 |
punct |
>,0.4 |
R2120 |
T3129 |
T3114 |
punct |
),effect |
R2121 |
T3127 |
T3125 |
nsubj |
p,0.4 |
R2122 |
T3131 |
T3132 |
det |
the,frequency |
R2123 |
T3130 |
T3110 |
cc |
and,interval |
R2124 |
T3133 |
T3132 |
amod |
overall,frequency |
R2125 |
T3132 |
T3110 |
conj |
frequency,interval |
R2126 |
T3135 |
T3136 |
punct |
(,effect |
R2127 |
T3136 |
T3132 |
parataxis |
effect,frequency |
R2128 |
T3134 |
T3132 |
compound |
licking,frequency |
R2129 |
T3138 |
T3136 |
punct |
: ,effect |
R2130 |
T3137 |
T3136 |
compound |
group,effect |
R2131 |
T3140 |
T3147 |
ccomp |
0.72,0.4 |
R2132 |
T3141 |
T3139 |
punct |
(,F |
R2133 |
T3139 |
T3140 |
nsubj |
F,0.72 |
R2134 |
T3143 |
T3139 |
punct |
",",F |
R2135 |
T3144 |
T3139 |
nummod |
10,F |
R2136 |
T3145 |
T3139 |
punct |
),F |
R2137 |
T3142 |
T3139 |
nummod |
1,F |
R2138 |
T3147 |
T3136 |
ccomp |
0.4,effect |
R2139 |
T3146 |
T3140 |
punct |
=,0.72 |
R2140 |
T3149 |
T3147 |
nsubj |
p,0.4 |
R2141 |
T3148 |
T3147 |
punct |
", ",0.4 |
R2142 |
T3151 |
T3136 |
punct |
),effect |
R2143 |
T3152 |
T3108 |
acomp |
unaffected,were |
R2144 |
T3150 |
T3147 |
punct |
>,0.4 |
R2145 |
T3157 |
T3156 |
punct |
", ",resulted |
R2146 |
T3153 |
T3093 |
punct |
.,was |
R2147 |
T3155 |
T3156 |
advmod |
Thus,resulted |
R2148 |
T3159 |
T3158 |
prep |
of,expression |
R2149 |
T3160 |
T3161 |
npadvmod |
Ca2,permeable |
R2150 |
T3158 |
T3156 |
nsubj |
expression,resulted |
R2151 |
T3162 |
T3160 |
punct |
+,Ca2 |
R2152 |
T3161 |
T3164 |
amod |
permeable,AMPARs |
R2153 |
T3164 |
T3159 |
pobj |
AMPARs,of |
R2154 |
T3163 |
T3161 |
punct |
-,permeable |
R2155 |
T3166 |
T3167 |
compound |
forebrain,areas |
R2156 |
T3165 |
T3158 |
prep |
in,expression |
R2157 |
T3168 |
T3167 |
punct |
", ",areas |
R2158 |
T3169 |
T3167 |
prep |
including,areas |
R2159 |
T3167 |
T3165 |
pobj |
areas,in |
R2160 |
T3171 |
T3169 |
pobj |
bulb,including |
R2161 |
T3172 |
T3171 |
amod |
olfactory,bulb |
R2162 |
T3173 |
T3156 |
punct |
", ",resulted |
R2163 |
T3170 |
T3171 |
det |
the,bulb |
R2164 |
T3175 |
T3176 |
advmod |
more,rapid |
R2165 |
T3174 |
T3156 |
prep |
in,resulted |
R2166 |
T3177 |
T3174 |
pobj |
learning,in |
R2167 |
T3176 |
T3177 |
amod |
rapid,learning |
R2168 |
T3179 |
T3177 |
cc |
and,learning |
R2169 |
T3178 |
T3177 |
compound |
odor,learning |
R2170 |
T3181 |
T3177 |
conj |
discrimination,learning |
R2171 |
T3180 |
T3181 |
amod |
enhanced,discrimination |
R2172 |
T3183 |
T3156 |
punct |
.,resulted |
R2174 |
T3182 |
T3181 |
amod |
olfactory,discrimination |
R2176 |
T3577 |
T3578 |
compound |
GluR,BΔFB |
R2177 |
T3578 |
T3580 |
compound |
BΔFB,Mice |
R2178 |
T3579 |
T3578 |
punct |
-,BΔFB |
R2179 |
T3580 |
T3581 |
nsubj |
Mice,Exhibit |
R2180 |
T3582 |
T3583 |
amod |
Increased,Performance |
R2181 |
T3583 |
T3581 |
dobj |
Performance,Exhibit |
R2182 |
T3584 |
T3585 |
compound |
Olfactory,Discrimination |
R2183 |
T3585 |
T3583 |
compound |
Discrimination,Performance |
R2184 |
T3587 |
T3588 |
aux |
To,ascertain |
R2185 |
T3588 |
T3589 |
advcl |
ascertain,analyzed |
R2186 |
T3590 |
T3591 |
mark |
if,correlate |
R2187 |
T3591 |
T3588 |
ccomp |
correlate,ascertain |
R2188 |
T3592 |
T3593 |
amod |
enhanced,learning |
R2189 |
T3593 |
T3591 |
nsubj |
learning,correlate |
R2190 |
T3594 |
T3593 |
amod |
olfactory,learning |
R2191 |
T3595 |
T3593 |
cc |
and,learning |
R2192 |
T3596 |
T3597 |
compound |
odor,discrimination |
R2193 |
T3597 |
T3593 |
conj |
discrimination,learning |
R2194 |
T3598 |
T3591 |
aux |
may,correlate |
R2195 |
T3599 |
T3591 |
advmod |
indeed,correlate |
R2196 |
T3600 |
T3591 |
prep |
with,correlate |
R2197 |
T3601 |
T3602 |
det |
the,permeability |
R2198 |
T3602 |
T3600 |
pobj |
permeability,with |
R2199 |
T3603 |
T3602 |
amod |
increased,permeability |
R2200 |
T3604 |
T3602 |
nmod |
Ca2,permeability |
R2201 |
T3605 |
T3604 |
punct |
+,Ca2 |
R2202 |
T3606 |
T3602 |
prep |
of,permeability |
R2203 |
T3607 |
T3608 |
compound |
AMPA,channels |
R2204 |
T3608 |
T3606 |
pobj |
channels,of |
R2205 |
T3609 |
T3591 |
prep |
in,correlate |
R2206 |
T3610 |
T3611 |
det |
the,form |
R2208 |
T3612 |
T3613 |
compound |
Q,R |
R2209 |
T3613 |
T3615 |
compound |
R,site |
R2210 |
T3614 |
T3613 |
punct |
/,R |
R2211 |
T3615 |
T3616 |
npadvmod |
site,unedited |
R2212 |
T3616 |
T3611 |
amod |
unedited,form |
R2213 |
T3617 |
T3616 |
punct |
-,unedited |
R2214 |
T3618 |
T3589 |
punct |
", ",analyzed |
R2215 |
T3619 |
T3589 |
nsubj |
we,analyzed |
R2216 |
T3620 |
T3589 |
advmod |
next,analyzed |
R2217 |
T3621 |
T3622 |
compound |
GluR,BΔFB |
R2218 |
T3622 |
T3624 |
compound |
BΔFB,mice |
R2219 |
T3623 |
T3622 |
punct |
-,BΔFB |
R2220 |
T3624 |
T3589 |
dobj |
mice,analyzed |
R2221 |
T3625 |
T3624 |
punct |
", ",mice |
R2222 |
T3626 |
T3627 |
dep |
which,lack |
R2223 |
T3627 |
T3624 |
relcl |
lack,mice |
R2224 |
T3628 |
T3629 |
compound |
GluR,B |
R2225 |
T3629 |
T3627 |
dobj |
B,lack |
R2226 |
T3630 |
T3629 |
punct |
-,B |
R2227 |
T3631 |
T3627 |
prep |
in,lack |
R2228 |
T3632 |
T3631 |
pobj |
forebrain,in |
R2229 |
T3633 |
T3589 |
punct |
.,analyzed |
R2230 |
T3635 |
T3636 |
det |
This,ablation |
R2231 |
T3636 |
T3638 |
nsubjpass |
ablation,generated |
R2232 |
T3637 |
T3636 |
amod |
specific,ablation |
R2233 |
T3639 |
T3638 |
auxpass |
was,generated |
R2234 |
T3640 |
T3638 |
prep |
by,generated |
R2235 |
T3641 |
T3642 |
npadvmod |
forebrain,selective |
R2236 |
T3642 |
T3644 |
amod |
selective,expression |
R2237 |
T3643 |
T3642 |
punct |
-,selective |
R2238 |
T3644 |
T3640 |
pobj |
expression,by |
R2239 |
T3645 |
T3644 |
compound |
TgCre4,expression |
R2240 |
T3646 |
T3647 |
punct |
(,Camkcre4 |
R2241 |
T3647 |
T3644 |
parataxis |
Camkcre4,expression |
R2242 |
T3648 |
T3647 |
punct |
[,Camkcre4 |
R2243 |
T3649 |
T3647 |
dep |
59,Camkcre4 |
R2244 |
T3650 |
T3647 |
punct |
],Camkcre4 |
R2245 |
T3651 |
T3647 |
punct |
“,Camkcre4 |
R2246 |
T3652 |
T3647 |
punct |
”,Camkcre4 |
R2247 |
T3653 |
T3647 |
punct |
),Camkcre4 |
R2248 |
T3654 |
T3638 |
prep |
in,generated |
R2249 |
T3655 |
T3656 |
npadvmod |
gene,targeted |
R2250 |
T3656 |
T3658 |
amod |
targeted,mice |
R2251 |
T3657 |
T3656 |
punct |
-,targeted |
R2252 |
T3658 |
T3654 |
pobj |
mice,in |
R2253 |
T3659 |
T3660 |
compound |
GluR,B2lox |
R2254 |
T3660 |
T3658 |
compound |
B2lox,mice |
R2255 |
T3661 |
T3660 |
punct |
-,B2lox |
R2256 |
T3662 |
T3658 |
acl |
carrying,mice |
R2257 |
T3663 |
T3662 |
punct |
", ",carrying |
R2258 |
T3664 |
T3662 |
prep |
in,carrying |
R2259 |
T3665 |
T3666 |
preconj |
both,alleles |
R2260 |
T3666 |
T3664 |
pobj |
alleles,in |
R2261 |
T3667 |
T3668 |
compound |
GluR,B |
R2262 |
T3668 |
T3666 |
compound |
B,alleles |
R2263 |
T3669 |
T3668 |
punct |
-,B |
R2264 |
T3670 |
T3662 |
punct |
", ",carrying |
R2265 |
T3671 |
T3672 |
det |
a,exon |
R2266 |
T3672 |
T3662 |
dobj |
exon,carrying |
R2267 |
T3673 |
T3672 |
amod |
floxed,exon |
R2268 |
T3674 |
T3672 |
nummod |
11,exon |
R2269 |
T3675 |
T3676 |
punct |
(,2A |
R2270 |
T3676 |
T3672 |
parataxis |
2A,exon |
R2271 |
T3677 |
T3676 |
compound |
Figure,2A |
R2272 |
T3678 |
T3676 |
punct |
),2A |
R2273 |
T3679 |
T3638 |
punct |
.,generated |
R2274 |
T3681 |
T3682 |
det |
The,depletion |
R2275 |
T3682 |
T3687 |
nsubjpass |
depletion,monitored |
R2276 |
T3683 |
T3682 |
amod |
specific,depletion |
R2277 |
T3684 |
T3685 |
compound |
GluR,B |
R2278 |
T3685 |
T3682 |
compound |
B,depletion |
R2279 |
T3686 |
T3685 |
punct |
-,B |
R2280 |
T3688 |
T3682 |
prep |
in,depletion |
R2281 |
T3689 |
T3690 |
compound |
GluR,BΔFB |
R2282 |
T3690 |
T3692 |
compound |
BΔFB,mice |
R2283 |
T3691 |
T3690 |
punct |
-,BΔFB |
R2284 |
T3692 |
T3688 |
pobj |
mice,in |
R2285 |
T3693 |
T3687 |
aux |
can,monitored |
R2286 |
T3694 |
T3687 |
auxpass |
be,monitored |
R2287 |
T3695 |
T3687 |
prep |
by,monitored |
R2288 |
T3696 |
T3695 |
pobj |
immunohistochemistry,by |
R2289 |
T3697 |
T3698 |
punct |
(,see |
R2290 |
T3698 |
T3696 |
parataxis |
see,immunohistochemistry |
R2291 |
T3699 |
T3698 |
advmod |
below,see |
R2292 |
T3700 |
T3698 |
punct |
),see |
R2293 |
T3701 |
T3696 |
cc |
and,immunohistochemistry |
R2294 |
T3702 |
T3696 |
conj |
immunoblotting,immunohistochemistry |
R2295 |
T3703 |
T3687 |
punct |
.,monitored |
R2296 |
T3705 |
T3706 |
prep |
In,found |
R2297 |
T3707 |
T3708 |
amod |
quantitative,analyses |
R2298 |
T3708 |
T3705 |
pobj |
analyses,In |
R2299 |
T3709 |
T3708 |
compound |
immunoblot,analyses |
R2300 |
T3710 |
T3706 |
punct |
", ",found |
R2301 |
T3711 |
T3706 |
nsubj |
we,found |
R2302 |
T3712 |
T3713 |
compound |
GluR,B |
R2303 |
T3713 |
T3715 |
compound |
B,levels |
R2304 |
T3714 |
T3713 |
punct |
-,B |
R2305 |
T3715 |
T3716 |
nsubj |
levels,reduced |
R2306 |
T3716 |
T3706 |
ccomp |
reduced,found |
R2307 |
T3717 |
T3716 |
prep |
to,reduced |
R2308 |
T3718 |
T3719 |
quantmod |
28,7 |
R2309 |
T3719 |
T3721 |
nummod |
7,% |
R2310 |
T3720 |
T3719 |
punct |
±,7 |
R2311 |
T3721 |
T3717 |
pobj |
%,to |
R2312 |
T3722 |
T3721 |
punct |
", ",% |
R2313 |
T3723 |
T3724 |
quantmod |
29,8 |
R2314 |
T3724 |
T3726 |
nummod |
8,% |
R2315 |
T3725 |
T3724 |
punct |
±,8 |
R2316 |
T3726 |
T3721 |
conj |
%,% |
R2317 |
T3727 |
T3726 |
punct |
", ",% |
R2318 |
T3728 |
T3726 |
cc |
and,% |
R2319 |
T3729 |
T3730 |
quantmod |
52,9 |
R2320 |
T3730 |
T3732 |
nummod |
9,% |
R2321 |
T3731 |
T3730 |
punct |
±,9 |
R2322 |
T3732 |
T3726 |
conj |
%,% |
R2323 |
T3733 |
T3734 |
punct |
(,SEM |
R2324 |
T3734 |
T3732 |
parataxis |
SEM,% |
R2325 |
T3735 |
T3734 |
punct |
±,SEM |
R2326 |
T3736 |
T3734 |
punct |
;,SEM |
R2327 |
T3737 |
T3738 |
nsubj |
n,10 |
R2328 |
T3738 |
T3734 |
ccomp |
10,SEM |
R2329 |
T3739 |
T3738 |
punct |
=,10 |
R2330 |
T3740 |
T3734 |
punct |
),SEM |
R2331 |
T3741 |
T3716 |
prep |
in,reduced |
R2332 |
T3742 |
T3743 |
det |
the,hippocampus |
R2333 |
T3743 |
T3741 |
pobj |
hippocampus,in |
R2334 |
T3744 |
T3743 |
punct |
", ",hippocampus |
R2335 |
T3745 |
T3746 |
amod |
cortical,areas |
R2336 |
T3746 |
T3743 |
conj |
areas,hippocampus |
R2337 |
T3747 |
T3746 |
punct |
", ",areas |
R2338 |
T3748 |
T3746 |
cc |
and,areas |
R2339 |
T3749 |
T3750 |
amod |
olfactory,bulb |
R2340 |
T3750 |
T3746 |
conj |
bulb,areas |
R2341 |
T3751 |
T3716 |
punct |
", ",reduced |
R2342 |
T3752 |
T3716 |
advmod |
respectively,reduced |
R2343 |
T3753 |
T3716 |
punct |
", ",reduced |
R2344 |
T3754 |
T3716 |
advcl |
relative,reduced |
R2345 |
T3755 |
T3754 |
prep |
to,relative |
R2346 |
T3756 |
T3757 |
compound |
GluR,B |
R2347 |
T3757 |
T3759 |
compound |
B,levels |
R2348 |
T3758 |
T3757 |
punct |
-,B |
R2349 |
T3759 |
T3755 |
pobj |
levels,to |
R2350 |
T3760 |
T3759 |
prep |
in,levels |
R2351 |
T3761 |
T3762 |
compound |
GluR,B2lox |
R2352 |
T3762 |
T3764 |
compound |
B2lox,controls |
R2353 |
T3763 |
T3762 |
punct |
-,B2lox |
R2354 |
T3764 |
T3760 |
pobj |
controls,in |
R2355 |
T3765 |
T3764 |
compound |
littermate,controls |
R2356 |
T3766 |
T3706 |
punct |
.,found |
R2357 |
T3768 |
T3769 |
prep |
In,become |
R2358 |
T3770 |
T3771 |
det |
the,absence |
R2359 |
T3771 |
T3768 |
pobj |
absence,In |
R2360 |
T3772 |
T3771 |
prep |
of,absence |
R2361 |
T3773 |
T3774 |
compound |
GluR,B |
R2362 |
T3774 |
T3772 |
pobj |
B,of |
R2363 |
T3775 |
T3774 |
punct |
-,B |
R2364 |
T3776 |
T3769 |
punct |
", ",become |
R2365 |
T3777 |
T3778 |
det |
the,properties |
R2366 |
T3778 |
T3769 |
nsubj |
properties,become |
R2367 |
T3779 |
T3778 |
amod |
electrophysiological,properties |
R2368 |
T3780 |
T3778 |
prep |
of,properties |
R2369 |
T3781 |
T3782 |
compound |
AMPA,channels |
R2370 |
T3782 |
T3780 |
pobj |
channels,of |
R2371 |
T3783 |
T3769 |
acomp |
similar,become |
R2372 |
T3784 |
T3783 |
prep |
to,similar |
R2373 |
T3785 |
T3784 |
pobj |
those,to |
R2374 |
T3786 |
T3785 |
prep |
with,those |
R2375 |
T3787 |
T3788 |
nmod |
GluR,B |
R2376 |
T3788 |
T3790 |
nmod |
B,switch |
R2377 |
T3789 |
T3788 |
punct |
-,B |
R2378 |
T3790 |
T3786 |
pobj |
switch,with |
R2379 |
T3791 |
T3788 |
punct |
/,B |
R2380 |
T3792 |
T3793 |
nmod |
GluR,Q |
R2381 |
T3793 |
T3788 |
appos |
Q,B |
R2382 |
T3794 |
T3793 |
punct |
-,Q |
R2383 |
T3795 |
T3793 |
nmod |
B,Q |
R2384 |
T3796 |
T3793 |
punct |
(,Q |
R2385 |
T3797 |
T3793 |
punct |
),Q |
R2386 |
T3798 |
T3799 |
punct |
[,51 |
R2387 |
T3799 |
T3790 |
parataxis |
51,switch |
R2388 |
T3800 |
T3799 |
punct |
],51 |
R2389 |
T3801 |
T3769 |
advcl |
showing,become |
R2390 |
T3802 |
T3803 |
amod |
strong,rectification |
R2391 |
T3803 |
T3801 |
dobj |
rectification,showing |
R2392 |
T3804 |
T3803 |
cc |
and,rectification |
R2393 |
T3805 |
T3806 |
amod |
increased,permeability |
R2394 |
T3806 |
T3803 |
conj |
permeability,rectification |
R2395 |
T3807 |
T3806 |
nmod |
Ca2,permeability |
R2396 |
T3808 |
T3807 |
punct |
+,Ca2 |
R2397 |
T3809 |
T3806 |
prep |
through,permeability |
R2398 |
T3810 |
T3811 |
compound |
AMPA,channels |
R2399 |
T3811 |
T3809 |
pobj |
channels,through |
R2400 |
T3812 |
T3813 |
punct |
(,data |
R2401 |
T3813 |
T3801 |
meta |
data,showing |
R2402 |
T3814 |
T3813 |
amod |
unpublished,data |
R2403 |
T3815 |
T3813 |
punct |
),data |
R2404 |
T3816 |
T3769 |
punct |
.,become |
R2405 |
T3818 |
T3819 |
advmod |
However,is |
R2406 |
T3820 |
T3819 |
punct |
", ",is |
R2407 |
T3821 |
T3822 |
compound |
GluR,B |
R2408 |
T3822 |
T3825 |
compound |
B,depletion |
R2409 |
T3823 |
T3822 |
punct |
-,B |
R2410 |
T3824 |
T3941 |
nsubj |
p,0.01 |
R2411 |
T3825 |
T3819 |
nsubj |
depletion,is |
R2412 |
T3826 |
T3819 |
neg |
not,is |
R2413 |
T3827 |
T3819 |
acomp |
lethal,is |
R2414 |
T3828 |
T3819 |
cc |
and,is |
R2415 |
T3829 |
T3830 |
aux |
does,produce |
R2416 |
T3830 |
T3819 |
conj |
produce,is |
R2417 |
T3831 |
T3830 |
neg |
not,produce |
R2418 |
T3832 |
T3830 |
dobj |
seizures,produce |
R2419 |
T3833 |
T3819 |
punct |
.,is |
R2420 |
T3835 |
T3836 |
prep |
In,appeared |
R2421 |
T3837 |
T3835 |
pobj |
addition,In |
R2422 |
T3838 |
T3836 |
punct |
", ",appeared |
R2423 |
T3839 |
T3836 |
prep |
in,appeared |
R2424 |
T3840 |
T3839 |
pobj |
contrast,in |
R2425 |
T3841 |
T3840 |
prep |
to,contrast |
R2426 |
T3842 |
T3843 |
det |
the,knockouts |
R2427 |
T3843 |
T3841 |
pobj |
knockouts,to |
R2428 |
T3844 |
T3843 |
amod |
complete,knockouts |
R2429 |
T3845 |
T3846 |
compound |
GluR,B |
R2430 |
T3846 |
T3843 |
compound |
B,knockouts |
R2431 |
T3847 |
T3846 |
punct |
-,B |
R2432 |
T3848 |
T3836 |
punct |
", ",appeared |
R2433 |
T3849 |
T3836 |
nsubj |
mice,appeared |
R2434 |
T3850 |
T3849 |
prep |
with,mice |
R2435 |
T3851 |
T3852 |
npadvmod |
forebrain,specific |
R2436 |
T3852 |
T3854 |
amod |
specific,depletion |
R2437 |
T3853 |
T3852 |
punct |
-,specific |
R2438 |
T3854 |
T3850 |
pobj |
depletion,with |
R2439 |
T3855 |
T3856 |
compound |
GluR,B |
R2440 |
T3856 |
T3854 |
compound |
B,depletion |
R2441 |
T3857 |
T3856 |
punct |
-,B |
R2442 |
T3858 |
T3836 |
oprd |
normal,appeared |
R2443 |
T3859 |
T3836 |
prep |
throughout,appeared |
R2444 |
T3860 |
T3859 |
pobj |
life,throughout |
R2445 |
T3861 |
T3836 |
prep |
with,appeared |
R2446 |
T3862 |
T3863 |
det |
no,abnormalities |
R2447 |
T3863 |
T3861 |
pobj |
abnormalities,with |
R2448 |
T3864 |
T3863 |
amod |
developmental,abnormalities |
R2449 |
T3865 |
T3863 |
punct |
", ",abnormalities |
R2450 |
T3866 |
T3863 |
cc |
or,abnormalities |
R2451 |
T3867 |
T3863 |
conj |
difference,abnormalities |
R2452 |
T3868 |
T3867 |
prep |
in,difference |
R2453 |
T3869 |
T3870 |
compound |
body,size |
R2454 |
T3870 |
T3868 |
pobj |
size,in |
R2455 |
T3871 |
T3870 |
cc |
and,size |
R2456 |
T3872 |
T3870 |
conj |
weight,size |
R2457 |
T3873 |
T3863 |
prep |
in,abnormalities |
R2458 |
T3874 |
T3873 |
pobj |
adulthood,in |
R2459 |
T3875 |
T3876 |
punct |
(,10 |
R2460 |
T3876 |
T3836 |
parataxis |
10,appeared |
R2461 |
T3877 |
T3878 |
amod |
wild,type |
R2462 |
T3878 |
T3880 |
dep |
type,g |
R2463 |
T3879 |
T3878 |
punct |
-,type |
R2464 |
T3880 |
T3876 |
dep |
g,10 |
R2465 |
T3881 |
T3880 |
punct |
: ,g |
R2466 |
T3882 |
T3880 |
nummod |
31.0,g |
R2467 |
T3883 |
T3880 |
punct |
±,g |
R2468 |
T3884 |
T3880 |
appos |
1.2,g |
R2469 |
T3885 |
T3876 |
punct |
;,10 |
R2470 |
T3886 |
T3887 |
compound |
GluR,BΔFB |
R2471 |
T3887 |
T3889 |
dep |
BΔFB,0.9 |
R2472 |
T3888 |
T3887 |
punct |
-,BΔFB |
R2473 |
T3889 |
T3876 |
dep |
0.9,10 |
R2474 |
T3890 |
T3889 |
punct |
: ,0.9 |
R2475 |
T3891 |
T3889 |
nummod |
28.4,0.9 |
R2476 |
T3892 |
T3889 |
punct |
±,0.9 |
R2477 |
T3893 |
T3876 |
punct |
;,10 |
R2478 |
T3894 |
T3895 |
det |
each,n |
R2479 |
T3895 |
T3876 |
nsubj |
n,10 |
R2480 |
T3896 |
T3876 |
punct |
=,10 |
R2481 |
T3897 |
T3876 |
punct |
),10 |
R2482 |
T3898 |
T3836 |
punct |
.,appeared |
R2483 |
T3900 |
T3901 |
amod |
Exploratory,activity |
R2484 |
T3901 |
T3902 |
nsubj |
activity,was |
R2485 |
T3903 |
T3901 |
prep |
in,activity |
R2486 |
T3904 |
T3905 |
det |
an,task |
R2487 |
T3905 |
T3903 |
pobj |
task,in |
R2488 |
T3906 |
T3907 |
amod |
open,field |
R2489 |
T3907 |
T3905 |
compound |
field,task |
R2490 |
T3908 |
T3909 |
advmod |
slightly,increased |
R2491 |
T3909 |
T3902 |
acomp |
increased,was |
R2492 |
T3910 |
T3902 |
prep |
in,was |
R2493 |
T3911 |
T3912 |
compound |
GluR,BΔFB |
R2494 |
T3912 |
T3914 |
compound |
BΔFB,mice |
R2495 |
T3913 |
T3912 |
punct |
-,BΔFB |
R2496 |
T3914 |
T3910 |
pobj |
mice,in |
R2497 |
T3915 |
T3916 |
punct |
(,cm |
R2498 |
T3916 |
T3914 |
parataxis |
cm,mice |
R2499 |
T3917 |
T3916 |
nummod |
"3,480",cm |
R2500 |
T3918 |
T3916 |
punct |
±,cm |
R2501 |
T3919 |
T3916 |
appos |
180,cm |
R2502 |
T3920 |
T3916 |
punct |
", ",cm |
R2503 |
T3921 |
T3922 |
nsubj |
n,11 |
R2504 |
T3922 |
T3916 |
ccomp |
11,cm |
R2505 |
T3923 |
T3922 |
punct |
=,11 |
R2506 |
T3924 |
T3916 |
punct |
),cm |
R2507 |
T3925 |
T3902 |
punct |
", ",was |
R2508 |
T3926 |
T3902 |
prep |
compared,was |
R2509 |
T3927 |
T3926 |
prep |
with,compared |
R2510 |
T3928 |
T3929 |
amod |
wild,type |
R2511 |
T3929 |
T3931 |
compound |
type,littermates |
R2512 |
T3930 |
T3929 |
punct |
-,type |
R2513 |
T3931 |
T3927 |
pobj |
littermates,with |
R2514 |
T3932 |
T3933 |
punct |
(,cm |
R2515 |
T3933 |
T3931 |
parataxis |
cm,littermates |
R2516 |
T3934 |
T3933 |
nummod |
"2,512",cm |
R2517 |
T3935 |
T3933 |
punct |
±,cm |
R2518 |
T3936 |
T3933 |
appos |
96,cm |
R2519 |
T3937 |
T3933 |
punct |
", ",cm |
R2520 |
T3938 |
T3939 |
nsubj |
n,12 |
R2521 |
T3939 |
T3941 |
ccomp |
12,0.01 |
R2522 |
T3940 |
T3939 |
punct |
=,12 |
R2523 |
T3941 |
T3933 |
ccomp |
0.01,cm |
R2524 |
T3942 |
T3941 |
punct |
", ",0.01 |
R2525 |
T3943 |
T3941 |
punct |
<,0.01 |
R2526 |
T3944 |
T3933 |
punct |
),cm |
R2527 |
T3945 |
T3902 |
punct |
.,was |
R2528 |
T3947 |
T3948 |
compound |
Motor,coordination |
R2529 |
T3948 |
T3949 |
nsubjpass |
coordination,impaired |
R2530 |
T3950 |
T3948 |
acl |
measured,coordination |
R2531 |
T3951 |
T3950 |
prep |
in,measured |
R2532 |
T3952 |
T3953 |
det |
an,rotarod |
R2533 |
T3953 |
T3951 |
pobj |
rotarod,in |
R2534 |
T3954 |
T3953 |
amod |
accelerating,rotarod |
R2535 |
T3955 |
T3949 |
auxpass |
was,impaired |
R2536 |
T3956 |
T3949 |
advmod |
somewhat,impaired |
R2537 |
T3957 |
T3949 |
prep |
in,impaired |
R2538 |
T3958 |
T3959 |
det |
the,mice |
R2539 |
T3959 |
T3957 |
pobj |
mice,in |
R2540 |
T3960 |
T3959 |
compound |
mutant,mice |
R2541 |
T3961 |
T3962 |
punct |
(,0.05 |
R2542 |
T3962 |
T3949 |
parataxis |
0.05,impaired |
R2543 |
T3963 |
T3964 |
amod |
wild,type |
R2544 |
T3964 |
T3966 |
dep |
type,6 |
R2545 |
T3965 |
T3964 |
punct |
-,type |
R2546 |
T3966 |
T3962 |
dep |
6,0.05 |
R2547 |
T3967 |
T3966 |
punct |
: ,6 |
R2548 |
T3968 |
T3969 |
nummod |
156,s |
R2549 |
T3969 |
T3966 |
dep |
s,6 |
R2550 |
T3970 |
T3969 |
punct |
±,s |
R2551 |
T3971 |
T3969 |
appos |
37,s |
R2552 |
T3972 |
T3966 |
punct |
", ",6 |
R2553 |
T3973 |
T3966 |
nsubj |
n,6 |
R2554 |
T3974 |
T3966 |
punct |
=,6 |
R2555 |
T3975 |
T3962 |
punct |
;,0.05 |
R2556 |
T3976 |
T3977 |
compound |
GluR,BΔFB |
R2557 |
T3977 |
T3979 |
dep |
BΔFB,6 |
R2558 |
T3978 |
T3977 |
punct |
-,BΔFB |
R2559 |
T3979 |
T3962 |
dep |
6,0.05 |
R2560 |
T3980 |
T3979 |
punct |
: ,6 |
R2561 |
T3981 |
T3982 |
nummod |
37,s |
R2562 |
T3982 |
T3979 |
dep |
s,6 |
R2563 |
T3983 |
T3982 |
punct |
±,s |
R2564 |
T3984 |
T3982 |
appos |
10,s |
R2565 |
T3985 |
T3979 |
punct |
", ",6 |
R2566 |
T3986 |
T3979 |
nsubj |
n,6 |
R2567 |
T3987 |
T3979 |
punct |
=,6 |
R2568 |
T3988 |
T3962 |
punct |
;,0.05 |
R2569 |
T3989 |
T3962 |
nsubj |
p,0.05 |
R2570 |
T3990 |
T3962 |
punct |
<,0.05 |
R2571 |
T3991 |
T3962 |
punct |
),0.05 |
R2572 |
T3992 |
T3949 |
punct |
.,impaired |
R2573 |
T3994 |
T3995 |
nsubj |
Tests,revealed |
R2574 |
T3996 |
T3994 |
prep |
in,Tests |
R2575 |
T3997 |
T3998 |
det |
the,box |
R2576 |
T3998 |
T3996 |
pobj |
box,in |
R2577 |
T3999 |
T4000 |
compound |
dark,light |
R2578 |
T4000 |
T3998 |
compound |
light,box |
R2579 |
T4001 |
T4000 |
punct |
/,light |
R2580 |
T4002 |
T4028 |
compound |
GluR,BΔFB |
R2581 |
T4003 |
T4004 |
amod |
increased,anxiety |
R2582 |
T4004 |
T3995 |
dobj |
anxiety,revealed |
R2583 |
T4005 |
T4004 |
prep |
of,anxiety |
R2584 |
T4006 |
T4007 |
compound |
GluR,BΔFB |
R2585 |
T4007 |
T4009 |
compound |
BΔFB,mice |
R2586 |
T4008 |
T4007 |
punct |
-,BΔFB |
R2587 |
T4009 |
T4005 |
pobj |
mice,of |
R2588 |
T4010 |
T4011 |
punct |
(,6 |
R2589 |
T4011 |
T3995 |
parataxis |
6,revealed |
R2590 |
T4012 |
T4013 |
dep |
latency,0.047 |
R2591 |
T4013 |
T4011 |
dep |
0.047,6 |
R2592 |
T4014 |
T4012 |
prep |
of,latency |
R2593 |
T4015 |
T4016 |
amod |
first,exit |
R2594 |
T4016 |
T4014 |
pobj |
exit,of |
R2595 |
T4017 |
T4013 |
punct |
: ,0.047 |
R2596 |
T4018 |
T4019 |
amod |
wild,type |
R2597 |
T4019 |
T4021 |
dep |
type,s |
R2598 |
T4020 |
T4019 |
punct |
-,type |
R2599 |
T4021 |
T4013 |
dep |
s,0.047 |
R2600 |
T4022 |
T4021 |
punct |
[,s |
R2601 |
T4023 |
T4021 |
nummod |
17,s |
R2602 |
T4024 |
T4021 |
punct |
±,s |
R2603 |
T4025 |
T4021 |
appos |
3,s |
R2604 |
T4026 |
T4021 |
punct |
],s |
R2605 |
T4027 |
T4013 |
punct |
", ",0.047 |
R2606 |
T4028 |
T4030 |
dep |
BΔFB,s |
R2607 |
T4029 |
T4028 |
punct |
-,BΔFB |
R2608 |
T4030 |
T4013 |
dep |
s,0.047 |
R2609 |
T4031 |
T4030 |
punct |
[,s |
R2610 |
T4032 |
T4030 |
nummod |
97,s |
R2611 |
T4033 |
T4030 |
punct |
±,s |
R2612 |
T4034 |
T4030 |
appos |
42,s |
R2613 |
T4035 |
T4030 |
punct |
],s |
R2614 |
T4036 |
T4013 |
punct |
", ",0.047 |
R2615 |
T4037 |
T4013 |
nsubj |
p,0.047 |
R2616 |
T4038 |
T4013 |
punct |
=,0.047 |
R2617 |
T4039 |
T4011 |
punct |
;,6 |
R2618 |
T4040 |
T4041 |
compound |
compartment,changes |
R2619 |
T4041 |
T4042 |
dep |
changes,0.05 |
R2620 |
T4042 |
T4011 |
dep |
0.05,6 |
R2621 |
T4043 |
T4042 |
punct |
: ,0.05 |
R2622 |
T4044 |
T4045 |
amod |
wild,type |
R2623 |
T4045 |
T4047 |
dep |
type,s |
R2624 |
T4046 |
T4045 |
punct |
-,type |
R2625 |
T4047 |
T4042 |
dep |
s,0.05 |
R2626 |
T4048 |
T4047 |
punct |
[,s |
R2627 |
T4049 |
T4047 |
nummod |
17,s |
R2628 |
T4050 |
T4047 |
punct |
±,s |
R2629 |
T4051 |
T4047 |
appos |
3,s |
R2630 |
T4052 |
T4047 |
punct |
],s |
R2631 |
T4053 |
T4042 |
punct |
", ",0.05 |
R2632 |
T4054 |
T4055 |
compound |
GluR,BΔFB |
R2633 |
T4055 |
T4057 |
dep |
BΔFB,2 |
R2634 |
T4056 |
T4055 |
punct |
-,BΔFB |
R2635 |
T4057 |
T4042 |
dep |
2,0.05 |
R2636 |
T4058 |
T4057 |
punct |
[,2 |
R2637 |
T4059 |
T4011 |
punct |
;,6 |
R2638 |
T4060 |
T4057 |
nummod |
7,2 |
R2639 |
T4061 |
T4124 |
pobj |
activity,in |
R2640 |
T4062 |
T4057 |
punct |
±,2 |
R2641 |
T4063 |
T4147 |
nmod |
B,alterations |
R2642 |
T4064 |
T4239 |
punct |
”,odors |
R2643 |
T4065 |
T4057 |
punct |
],2 |
R2644 |
T4066 |
T4042 |
punct |
", ",0.05 |
R2645 |
T4067 |
T4042 |
nsubj |
p,0.05 |
R2646 |
T4068 |
T4042 |
punct |
<,0.05 |
R2647 |
T4069 |
T4070 |
dep |
time,0.051 |
R2648 |
T4070 |
T4011 |
dep |
0.051,6 |
R2649 |
T4071 |
T4069 |
acl |
spent,time |
R2650 |
T4072 |
T4071 |
prep |
in,spent |
R2651 |
T4073 |
T4074 |
amod |
lit,compartment |
R2652 |
T4074 |
T4072 |
pobj |
compartment,in |
R2653 |
T4075 |
T4070 |
punct |
: ,0.051 |
R2654 |
T4076 |
T4077 |
amod |
wild,type |
R2655 |
T4077 |
T4079 |
dep |
type,s |
R2656 |
T4078 |
T4077 |
punct |
-,type |
R2657 |
T4079 |
T4070 |
dep |
s,0.051 |
R2658 |
T4080 |
T4079 |
punct |
[,s |
R2659 |
T4081 |
T4079 |
nummod |
103,s |
R2660 |
T4082 |
T4079 |
punct |
±,s |
R2661 |
T4083 |
T4079 |
appos |
10,s |
R2662 |
T4084 |
T4079 |
punct |
],s |
R2663 |
T4085 |
T4070 |
punct |
", ",0.051 |
R2664 |
T4086 |
T4087 |
compound |
GluR,BΔFB |
R2665 |
T4087 |
T4089 |
dep |
BΔFB,s |
R2666 |
T4088 |
T4087 |
punct |
-,BΔFB |
R2667 |
T4089 |
T4070 |
dep |
s,0.051 |
R2668 |
T4090 |
T4089 |
punct |
[,s |
R2669 |
T4091 |
T4089 |
nummod |
59,s |
R2670 |
T4092 |
T4089 |
punct |
±,s |
R2671 |
T4093 |
T4089 |
appos |
19,s |
R2672 |
T4094 |
T4089 |
punct |
],s |
R2673 |
T4095 |
T4070 |
punct |
", ",0.051 |
R2674 |
T4096 |
T4070 |
nsubj |
p,0.051 |
R2675 |
T4097 |
T4070 |
punct |
=,0.051 |
R2676 |
T4098 |
T4011 |
punct |
;,6 |
R2677 |
T4099 |
T4100 |
det |
each,n |
R2678 |
T4100 |
T4011 |
nsubj |
n,6 |
R2679 |
T4101 |
T4011 |
punct |
=,6 |
R2680 |
T4102 |
T4011 |
punct |
),6 |
R2681 |
T4103 |
T3995 |
punct |
.,revealed |
R2682 |
T4105 |
T4106 |
advmod |
Hence,show |
R2683 |
T4107 |
T4106 |
punct |
", ",show |
R2684 |
T4108 |
T4106 |
prep |
unlike,show |
R2685 |
T4109 |
T4110 |
det |
the,knockouts |
R2686 |
T4110 |
T4108 |
pobj |
knockouts,unlike |
R2687 |
T4111 |
T4110 |
amod |
complete,knockouts |
R2688 |
T4112 |
T4113 |
compound |
GluR,B |
R2689 |
T4113 |
T4110 |
compound |
B,knockouts |
R2690 |
T4114 |
T4113 |
punct |
-,B |
R2691 |
T4115 |
T4106 |
punct |
", ",show |
R2692 |
T4116 |
T4117 |
compound |
GluR,BΔFB |
R2693 |
T4117 |
T4119 |
compound |
BΔFB,mice |
R2694 |
T4118 |
T4117 |
punct |
-,BΔFB |
R2695 |
T4119 |
T4106 |
nsubj |
mice,show |
R2696 |
T4120 |
T4121 |
advmod |
only,changes |
R2697 |
T4121 |
T4106 |
dobj |
changes,show |
R2698 |
T4122 |
T4123 |
advmod |
very,minor |
R2699 |
T4123 |
T4121 |
amod |
minor,changes |
R2700 |
T4124 |
T4121 |
prep |
in,changes |
R2701 |
T4125 |
T4061 |
amod |
general,activity |
R2702 |
T4126 |
T4121 |
cc |
and,changes |
R2703 |
T4127 |
T4128 |
det |
no,sign |
R2704 |
T4128 |
T4121 |
conj |
sign,changes |
R2705 |
T4129 |
T4128 |
prep |
of,sign |
R2706 |
T4130 |
T4131 |
det |
any,disturbance |
R2707 |
T4131 |
T4129 |
pobj |
disturbance,of |
R2708 |
T4132 |
T4131 |
amod |
major,disturbance |
R2709 |
T4133 |
T4131 |
amod |
developmental,disturbance |
R2710 |
T4134 |
T4106 |
punct |
", ",show |
R2711 |
T4135 |
T4136 |
advmod |
thus,allowing |
R2712 |
T4136 |
T4106 |
advcl |
allowing,show |
R2713 |
T4137 |
T4138 |
amod |
detailed,investigations |
R2714 |
T4138 |
T4136 |
dobj |
investigations,allowing |
R2715 |
T4139 |
T4138 |
punct |
", ",investigations |
R2716 |
T4140 |
T4138 |
amod |
quantitative,investigations |
R2717 |
T4141 |
T4138 |
amod |
behavioral,investigations |
R2718 |
T4142 |
T4106 |
punct |
.,show |
R2719 |
T4144 |
T4145 |
mark |
If,linked |
R2720 |
T4145 |
T4170 |
advcl |
linked,lead |
R2721 |
T4146 |
T4147 |
det |
the,alterations |
R2722 |
T4147 |
T4145 |
nsubjpass |
alterations,linked |
R2723 |
T4148 |
T4063 |
nmod |
GluR,B |
R2724 |
T4149 |
T4063 |
punct |
-,B |
R2725 |
T4150 |
T4063 |
punct |
/,B |
R2726 |
T4151 |
T4152 |
compound |
GluR,B |
R2727 |
T4152 |
T4063 |
appos |
B,B |
R2728 |
T4153 |
T4152 |
punct |
-,B |
R2729 |
T4154 |
T4155 |
punct |
(,Q |
R2730 |
T4155 |
T4063 |
parataxis |
Q,B |
R2731 |
T4156 |
T4155 |
punct |
),Q |
R2732 |
T4157 |
T4158 |
npadvmod |
switch,induced |
R2733 |
T4158 |
T4147 |
amod |
induced,alterations |
R2734 |
T4159 |
T4158 |
punct |
-,induced |
R2735 |
T4160 |
T4147 |
prep |
in,alterations |
R2736 |
T4161 |
T4162 |
det |
the,permeability |
R2737 |
T4162 |
T4160 |
pobj |
permeability,in |
R2738 |
T4163 |
T4162 |
nmod |
Ca2,permeability |
R2739 |
T4164 |
T4163 |
punct |
+,Ca2 |
R2740 |
T4165 |
T4162 |
prep |
of,permeability |
R2741 |
T4166 |
T4167 |
det |
the,channels |
R2742 |
T4167 |
T4165 |
pobj |
channels,of |
R2743 |
T4168 |
T4167 |
compound |
AMPA,channels |
R2744 |
T4169 |
T4145 |
auxpass |
are,linked |
R2745 |
T4171 |
T4145 |
prep |
to,linked |
R2746 |
T4172 |
T4173 |
amod |
enhanced,discrimination |
R2747 |
T4173 |
T4171 |
pobj |
discrimination,to |
R2748 |
T4174 |
T4173 |
compound |
odor,discrimination |
R2749 |
T4175 |
T4173 |
cc |
and,discrimination |
R2750 |
T4176 |
T4173 |
conj |
learning,discrimination |
R2751 |
T4177 |
T4170 |
punct |
", ",lead |
R2752 |
T4178 |
T4179 |
det |
the,depletion |
R2753 |
T4179 |
T4170 |
nsubj |
depletion,lead |
R2754 |
T4180 |
T4179 |
prep |
of,depletion |
R2755 |
T4181 |
T4182 |
det |
the,subunit |
R2756 |
T4182 |
T4180 |
pobj |
subunit,of |
R2757 |
T4183 |
T4184 |
compound |
GluR,B |
R2758 |
T4184 |
T4182 |
compound |
B,subunit |
R2759 |
T4185 |
T4184 |
punct |
-,B |
R2760 |
T4186 |
T4170 |
aux |
should,lead |
R2761 |
T4187 |
T4170 |
prep |
to,lead |
R2762 |
T4188 |
T4189 |
det |
a,readout |
R2763 |
T4189 |
T4187 |
pobj |
readout,to |
R2764 |
T4190 |
T4189 |
amod |
similar,readout |
R2765 |
T4191 |
T4189 |
amod |
phenotypic,readout |
R2766 |
T4192 |
T4170 |
punct |
.,lead |
R2767 |
T4194 |
T4195 |
nsubj |
We,trained |
R2768 |
T4196 |
T4195 |
advmod |
therefore,trained |
R2769 |
T4197 |
T4198 |
nummod |
nine,mice |
R2770 |
T4198 |
T4195 |
dobj |
mice,trained |
R2771 |
T4199 |
T4200 |
compound |
GluR,BΔFB |
R2772 |
T4200 |
T4198 |
compound |
BΔFB,mice |
R2773 |
T4201 |
T4200 |
punct |
-,BΔFB |
R2774 |
T4202 |
T4198 |
cc |
and,mice |
R2775 |
T4203 |
T4204 |
nummod |
nine,controls |
R2776 |
T4204 |
T4198 |
conj |
controls,mice |
R2777 |
T4205 |
T4204 |
compound |
littermate,controls |
R2778 |
T4206 |
T4195 |
prep |
in,trained |
R2779 |
T4207 |
T4208 |
det |
the,task |
R2780 |
T4208 |
T4206 |
pobj |
task,in |
R2781 |
T4209 |
T4208 |
amod |
same,task |
R2782 |
T4210 |
T4208 |
amod |
automated,task |
R2783 |
T4211 |
T4208 |
amod |
associative,task |
R2784 |
T4212 |
T4208 |
nmod |
go,task |
R2785 |
T4213 |
T4212 |
punct |
/,go |
R2786 |
T4214 |
T4215 |
det |
no,go |
R2787 |
T4215 |
T4212 |
appos |
go,go |
R2788 |
T4216 |
T4215 |
punct |
-,go |
R2789 |
T4217 |
T4218 |
amod |
olfactory,conditioning |
R2790 |
T4218 |
T4208 |
compound |
conditioning,task |
R2791 |
T4219 |
T4208 |
acl |
described,task |
R2792 |
T4220 |
T4219 |
advmod |
above,described |
R2793 |
T4221 |
T4195 |
punct |
.,trained |
R2794 |
T4223 |
T4224 |
aux |
To,cover |
R2795 |
T4224 |
T4225 |
advcl |
cover,tested |
R2796 |
T4226 |
T4227 |
advmod |
even,changes |
R2797 |
T4227 |
T4224 |
dobj |
changes,cover |
R2798 |
T4228 |
T4227 |
amod |
small,changes |
R2799 |
T4229 |
T4227 |
amod |
phenotypic,changes |
R2800 |
T4230 |
T4227 |
prep |
in,changes |
R2801 |
T4231 |
T4230 |
pobj |
olfaction,in |
R2802 |
T4232 |
T4225 |
punct |
", ",tested |
R2803 |
T4233 |
T4225 |
nsubj |
we,tested |
R2804 |
T4234 |
T4235 |
amod |
different,pairs |
R2805 |
T4235 |
T4225 |
dobj |
pairs,tested |
R2806 |
T4236 |
T4235 |
compound |
odor,pairs |
R2807 |
T4237 |
T4235 |
punct |
", ",pairs |
R2808 |
T4238 |
T4239 |
punct |
“,odors |
R2809 |
T4239 |
T4235 |
conj |
odors,pairs |
R2810 |
T4240 |
T4239 |
amod |
simple,odors |
R2811 |
T4241 |
T4239 |
amod |
monomolecular,odors |
R2812 |
T4242 |
T4239 |
cc |
and,odors |
R2813 |
T4243 |
T4244 |
punct |
“,mixtures |
R2814 |
T4244 |
T4239 |
conj |
mixtures,odors |
R2815 |
T4245 |
T4244 |
amod |
difficult,mixtures |
R2816 |
T4246 |
T4244 |
punct |
”,mixtures |
R2817 |
T4247 |
T4244 |
amod |
binary,mixtures |
R2818 |
T4248 |
T4249 |
punct |
[,3 |
R2819 |
T4249 |
T4225 |
parataxis |
3,tested |
R2820 |
T4250 |
T4249 |
punct |
],3 |
R2821 |
T4251 |
T4225 |
punct |
.,tested |
R2822 |
T4253 |
T4254 |
prep |
After,trained |
R2823 |
T4255 |
T4253 |
pobj |
habituation,After |
R2824 |
T4256 |
T4254 |
punct |
", ",trained |
R2825 |
T4257 |
T4258 |
nmod |
GluR,BΔFB |
R2826 |
T4258 |
T4260 |
nmod |
BΔFB,mice |
R2827 |
T4259 |
T4258 |
punct |
-,BΔFB |
R2828 |
T4260 |
T4254 |
nsubjpass |
mice,trained |
R2829 |
T4261 |
T4258 |
cc |
and,BΔFB |
R2830 |
T4262 |
T4258 |
conj |
control,BΔFB |
R2831 |
T4263 |
T4254 |
auxpass |
were,trained |
R2832 |
T4264 |
T4265 |
aux |
to,discriminate |
R2833 |
T4265 |
T4254 |
advcl |
discriminate,trained |
R2834 |
T4266 |
T4265 |
prep |
between,discriminate |
R2835 |
T4267 |
T4268 |
det |
the,odors |
R2836 |
T4268 |
T4266 |
pobj |
odors,between |
R2837 |
T4269 |
T4268 |
punct |
“,odors |
R2838 |
T4270 |
T4268 |
amod |
simple,odors |
R2839 |
T4271 |
T4268 |
punct |
”,odors |
R2840 |
T4272 |
T4268 |
amod |
monomolecular,odors |
R2841 |
T4273 |
T4268 |
appos |
amylacetate,odors |
R2842 |
T4274 |
T4273 |
cc |
and,amylacetate |
R2843 |
T4275 |
T4273 |
conj |
ethylbutyrate,amylacetate |
R2844 |
T4276 |
T4265 |
punct |
", ",discriminate |
R2845 |
T4277 |
T4265 |
cc |
and,discriminate |
R2846 |
T4278 |
T4279 |
advmod |
subsequently,on |
R2847 |
T4279 |
T4265 |
conj |
on,discriminate |
R2848 |
T4280 |
T4279 |
advmod |
additionally,on |
R2849 |
T4281 |
T4282 |
det |
a,task |
R2850 |
T4282 |
T4279 |
pobj |
task,on |
R2851 |
T4283 |
T4282 |
punct |
“,task |
R2852 |
T4284 |
T4282 |
amod |
difficult,task |
R2853 |
T4285 |
T4282 |
punct |
”,task |
R2854 |
T4286 |
T4282 |
compound |
discrimination,task |
R2855 |
T4287 |
T4282 |
acl |
consisting,task |
R2856 |
T4288 |
T4287 |
prep |
of,consisting |
R2857 |
T4289 |
T4290 |
amod |
similar,mixtures |
R2858 |
T4290 |
T4288 |
pobj |
mixtures,of |
R2859 |
T4291 |
T4290 |
amod |
binary,mixtures |
R2860 |
T4292 |
T4290 |
prep |
of,mixtures |
R2861 |
T4293 |
T4292 |
pobj |
cineol,of |
R2862 |
T4294 |
T4293 |
cc |
and,cineol |
R2863 |
T4295 |
T4293 |
conj |
eugenol,cineol |
R2864 |
T4296 |
T4279 |
punct |
;,on |
R2865 |
T4297 |
T4279 |
cc |
and,on |
R2866 |
T4298 |
T4299 |
advmod |
finally,on |
R2867 |
T4299 |
T4279 |
conj |
on,on |
R2868 |
T4300 |
T4299 |
advmod |
again,on |
R2869 |
T4301 |
T4302 |
det |
a,task |
R2870 |
T4302 |
T4299 |
pobj |
task,on |
R2871 |
T4303 |
T4302 |
punct |
“,task |
R2872 |
T4304 |
T4302 |
amod |
simple,task |
R2873 |
T4305 |
T4302 |
punct |
”,task |
R2874 |
T4306 |
T4302 |
compound |
discrimination,task |
R2875 |
T4307 |
T4302 |
prep |
with,task |
R2876 |
T4308 |
T4309 |
det |
the,odors |
R2877 |
T4309 |
T4307 |
pobj |
odors,with |
R2878 |
T4310 |
T4309 |
amod |
monomolecular,odors |
R2879 |
T4311 |
T4312 |
amod |
pelargonic,acid |
R2880 |
T4312 |
T4309 |
appos |
acid,odors |
R2881 |
T4313 |
T4311 |
cc |
and,pelargonic |
R2882 |
T4314 |
T4311 |
conj |
valeric,pelargonic |
R2883 |
T4315 |
T4254 |
punct |
.,trained |
R2884 |
T4317 |
T4318 |
advcl |
Similar,showed |
R2885 |
T4319 |
T4317 |
prep |
to,Similar |
R2886 |
T4320 |
T4321 |
compound |
GluR,BΔECS |
R2887 |
T4321 |
T4319 |
pobj |
BΔECS,to |
R2888 |
T4322 |
T4321 |
punct |
-,BΔECS |
R2889 |
T4323 |
T4321 |
punct |
:,BΔECS |
R2890 |
T4324 |
T4321 |
appos |
FB,BΔECS |
R2891 |
T4325 |
T4318 |
punct |
", ",showed |
R2892 |
T4326 |
T4327 |
compound |
GluR,BΔFB |
R2893 |
T4327 |
T4329 |
compound |
BΔFB,mice |
R2894 |
T4328 |
T4327 |
punct |
-,BΔFB |
R2895 |
T4329 |
T4318 |
nsubj |
mice,showed |
R2896 |
T4330 |
T4318 |
advmod |
also,showed |
R2897 |
T4331 |
T4332 |
amod |
enhanced,learning |
R2898 |
T4332 |
T4318 |
dobj |
learning,showed |
R2899 |
T4333 |
T4332 |
cc |
and,learning |
R2900 |
T4334 |
T4332 |
conj |
discrimination,learning |
R2901 |
T4335 |
T4318 |
prep |
compared,showed |
R2902 |
T4336 |
T4335 |
prep |
with,compared |
R2903 |
T4337 |
T4336 |
pobj |
controls,with |
R2904 |
T4338 |
T4339 |
punct |
(,2B |
R2905 |
T4339 |
T4318 |
parataxis |
2B,showed |
R2906 |
T4340 |
T4339 |
compound |
Figure,2B |
R2907 |
T4341 |
T4339 |
punct |
;,2B |
R2908 |
T4342 |
T4343 |
compound |
group,effect |
R2909 |
T4343 |
T4344 |
dep |
effect,0.05 |
R2910 |
T4344 |
T4339 |
dep |
0.05,2B |
R2911 |
T4345 |
T4344 |
punct |
: ,0.05 |
R2912 |
T4346 |
T4347 |
nsubj |
F,6.55 |
R2913 |
T4347 |
T4344 |
ccomp |
6.55,0.05 |
R2914 |
T4348 |
T4346 |
punct |
(,F |
R2915 |
T4349 |
T4346 |
nummod |
1,F |
R2916 |
T4350 |
T4346 |
punct |
",",F |
R2917 |
T4352 |
T4346 |
punct |
),F |
R2918 |
T4353 |
T4347 |
punct |
=,6.55 |
R2919 |
T4354 |
T4344 |
punct |
;,0.05 |
R2920 |
T4355 |
T4344 |
nsubj |
p,0.05 |
R2921 |
T4356 |
T4344 |
punct |
<,0.05 |
R2922 |
T4357 |
T4339 |
punct |
),2B |
R2923 |
T4358 |
T4318 |
punct |
.,showed |
R2924 |
T4360 |
T4361 |
amod |
Increased,performance |
R2925 |
T4361 |
T4363 |
nsubjpass |
performance,expected |
R2926 |
T4362 |
T4361 |
compound |
discrimination,performance |
R2927 |
T4364 |
T4363 |
auxpass |
is,expected |
R2928 |
T4365 |
T4366 |
aux |
to,show |
R2929 |
T4351 |
T4346 |
nummod |
16,F |
R2930 |
T4367 |
T4368 |
advmod |
more,pronounced |
R2931 |
T4368 |
T4369 |
amod |
pronounced,effects |
R2932 |
T4366 |
T4363 |
xcomp |
show,expected |
R2933 |
T4370 |
T4369 |
prep |
for,effects |
R2934 |
T4371 |
T4372 |
advmod |
closely,related |
R2935 |
T4372 |
T4373 |
amod |
related,odors |
R2936 |
T4369 |
T4366 |
dobj |
effects,show |
R2937 |
T4374 |
T4366 |
prep |
because,show |
R2938 |
T4375 |
T4374 |
pcomp |
of,because |
R2939 |
T4373 |
T4370 |
pobj |
odors,for |
R2940 |
T4377 |
T4374 |
pobj |
task,because |
R2941 |
T4378 |
T4379 |
advmod |
more,challenging |
R2942 |
T4376 |
T4377 |
det |
the,task |
R2943 |
T4380 |
T4377 |
punct |
“,task |
R2944 |
T4381 |
T4377 |
amod |
difficult,task |
R2945 |
T4379 |
T4377 |
amod |
challenging,task |
R2946 |
T4383 |
T4377 |
compound |
discrimination,task |
R2947 |
T4384 |
T4385 |
dep |
that,is |
R2948 |
T4382 |
T4377 |
punct |
”,task |
R2949 |
T4386 |
T4385 |
acomp |
closer,is |
R2950 |
T4387 |
T4386 |
prep |
to,closer |
R2951 |
T4385 |
T4377 |
relcl |
is,task |
R2952 |
T4389 |
T4387 |
pobj |
limits,to |
R2953 |
T4388 |
T4389 |
det |
the,limits |
R2954 |
T4391 |
T4389 |
prep |
of,limits |
R2955 |
T4392 |
T4393 |
det |
the,system |
R2956 |
T4390 |
T4389 |
amod |
psychophysical,limits |
R2957 |
T4394 |
T4395 |
punct |
[,4 |
R2958 |
T4395 |
T4363 |
parataxis |
4,expected |
R2959 |
T4393 |
T4391 |
pobj |
system,of |
R2960 |
T4397 |
T4395 |
punct |
",",4 |
R2961 |
T4398 |
T4395 |
punct |
],4 |
R2962 |
T4396 |
T4395 |
nummod |
3,4 |
R2963 |
T4402 |
T4415 |
ccomp |
were,0.01 |
R2964 |
T4399 |
T4363 |
punct |
.,expected |
R2965 |
T4403 |
T4401 |
prep |
with,Consistent |
R2966 |
T4401 |
T4402 |
advcl |
Consistent,were |
R2967 |
T4405 |
T4403 |
pobj |
notion,with |
R2968 |
T4404 |
T4405 |
det |
this,notion |
R2969 |
T4406 |
T4402 |
punct |
", ",were |
R2970 |
T4408 |
T4407 |
prep |
between,differences |
R2971 |
T4409 |
T4410 |
nmod |
GluR,BΔFB |
R2972 |
T4407 |
T4402 |
nsubj |
differences,were |
R2973 |
T4411 |
T4410 |
punct |
-,BΔFB |
R2974 |
T4412 |
T4408 |
pobj |
mice,between |
R2975 |
T4410 |
T4412 |
nmod |
BΔFB,mice |
R2976 |
T4414 |
T4410 |
conj |
control,BΔFB |
R2977 |
T4417 |
T4402 |
acomp |
larger,were |
R2978 |
T4413 |
T4410 |
cc |
and,BΔFB |
R2979 |
T4418 |
T4416 |
advmod |
only,not |
R2980 |
T4416 |
T4417 |
preconj |
not,larger |
R2981 |
T4420 |
T4417 |
ccomp |
investigated,larger |
R2982 |
T4421 |
T4422 |
det |
the,pattern |
R2983 |
T4419 |
T4420 |
mark |
if,investigated |
R2984 |
T4423 |
T4422 |
amod |
detailed,pattern |
R2985 |
T4424 |
T4422 |
compound |
sampling,pattern |
R2986 |
T4422 |
T4420 |
nsubjpass |
pattern,investigated |
R2987 |
T4426 |
T4427 |
compound |
discrimination,index |
R2988 |
T4427 |
T4422 |
conj |
index,pattern |
R2989 |
T4425 |
T4422 |
cc |
and,pattern |
R2990 |
T4429 |
T4430 |
punct |
(,2C |
R2991 |
T4428 |
T4420 |
auxpass |
were,investigated |
R2992 |
T4431 |
T4430 |
compound |
Figure,2C |
R2993 |
T4432 |
T4430 |
cc |
and,2C |
R2994 |
T4430 |
T4420 |
parataxis |
2C,investigated |
R2995 |
T4434 |
T4430 |
punct |
", ",2C |
R2996 |
T4435 |
T4436 |
compound |
group,effect |
R2997 |
T4433 |
T4430 |
conj |
2D,2C |
R2998 |
T4437 |
T4430 |
dep |
4,2C |
R2999 |
T4438 |
T4437 |
punct |
: ,4 |
R3000 |
T4436 |
T4437 |
dep |
effect,4 |
R3002 |
T4441 |
T4439 |
punct |
(,F |
R3003 |
T4439 |
T4440 |
nsubj |
F,29.5 |
R3004 |
T4443 |
T4672 |
neg |
not,improved |
R3005 |
T4442 |
T4439 |
nummod |
1,F |
R3006 |
T4445 |
T4703 |
det |
the,performance |
R3007 |
T4446 |
T4742 |
cc |
and,BΔECS |
R3008 |
T4444 |
T4439 |
punct |
",",F |
R3009 |
T4448 |
T4439 |
punct |
),F |
R3010 |
T4449 |
T4440 |
punct |
=,29.5 |
R3011 |
T4447 |
T4439 |
nummod |
16,F |
R3012 |
T4451 |
T4437 |
nsubj |
p,4 |
R3013 |
T4452 |
T4437 |
punct |
<,4 |
R3014 |
T4453 |
T4437 |
nummod |
10,4 |
R3015 |
T4450 |
T4437 |
punct |
;,4 |
R3016 |
T4455 |
T4430 |
punct |
),2C |
R3017 |
T4456 |
T4417 |
punct |
", ",larger |
R3018 |
T4457 |
T4417 |
cc |
but,larger |
R3019 |
T4454 |
T4437 |
punct |
−,4 |
R3020 |
T4459 |
T4417 |
conj |
for,larger |
R3021 |
T4458 |
T4459 |
prep |
in,for |
R3022 |
T4461 |
T4462 |
det |
the,discrimination |
R3023 |
T4462 |
T4459 |
pobj |
discrimination,for |
R3024 |
T4460 |
T4458 |
amod |
particular,in |
R3025 |
T4464 |
T4465 |
amod |
binary,mixtures |
R3026 |
T4465 |
T4463 |
pobj |
mixtures,of |
R3027 |
T4463 |
T4462 |
prep |
of,discrimination |
R3028 |
T4467 |
T4468 |
amod |
similar,composition |
R3029 |
T4466 |
T4465 |
prep |
with,mixtures |
R3030 |
T4469 |
T4470 |
punct |
(,4 |
R3031 |
T4470 |
T4468 |
parataxis |
4,composition |
R3032 |
T4468 |
T4466 |
pobj |
composition,with |
R3033 |
T4472 |
T4473 |
dep |
effect,27.8 |
R3034 |
T4473 |
T4470 |
dep |
27.8,4 |
R3035 |
T4471 |
T4472 |
compound |
group,effect |
R3036 |
T4475 |
T4473 |
nsubj |
F,27.8 |
R3037 |
T4476 |
T4475 |
punct |
(,F |
R3038 |
T4474 |
T4473 |
punct |
: ,27.8 |
R3039 |
T4478 |
T4475 |
punct |
",",F |
R3040 |
T4477 |
T4475 |
nummod |
1,F |
R3041 |
T4480 |
T4475 |
punct |
),F |
R3042 |
T4481 |
T4473 |
punct |
=,27.8 |
R3043 |
T4479 |
T4475 |
nummod |
16,F |
R3044 |
T4483 |
T4470 |
nsubj |
p,4 |
R3045 |
T4482 |
T4470 |
punct |
;,4 |
R3046 |
T4485 |
T4470 |
nummod |
10,4 |
R3047 |
T4486 |
T4470 |
punct |
−,4 |
R3048 |
T4484 |
T4470 |
punct |
<,4 |
R3049 |
T4488 |
T4489 |
det |
the,mixture |
R3050 |
T4487 |
T4466 |
prep |
for,with |
R3051 |
T4490 |
T4415 |
punct |
;,0.01 |
R3052 |
T4491 |
T4492 |
compound |
FAA,EB |
R3053 |
T4489 |
T4487 |
pobj |
mixture,for |
R3054 |
T4493 |
T4415 |
ccomp |
7.0,0.01 |
R3055 |
T4494 |
T4492 |
punct |
(,EB |
R3056 |
T4492 |
T4493 |
nsubj |
EB,7.0 |
R3057 |
T4496 |
T4492 |
punct |
",",EB |
R3058 |
T4497 |
T4492 |
nummod |
16,EB |
R3059 |
T4495 |
T4492 |
nummod |
1,EB |
R3060 |
T4499 |
T4493 |
punct |
=,7.0 |
R3061 |
T4498 |
T4492 |
punct |
),EB |
R3062 |
T4501 |
T4502 |
nsubj |
p,0.02 |
R3063 |
T4502 |
T4493 |
conj |
0.02,7.0 |
R3064 |
T4500 |
T4493 |
punct |
;,7.0 |
R3065 |
T4504 |
T4502 |
punct |
", ",0.02 |
R3066 |
T4505 |
T4502 |
cc |
and,0.02 |
R3067 |
T4503 |
T4502 |
punct |
=,0.02 |
R3068 |
T4507 |
T4508 |
nsubj |
Val,5.8 |
R3069 |
T4508 |
T4502 |
conj |
5.8,0.02 |
R3070 |
T4506 |
T4507 |
compound |
FPel,Val |
R3071 |
T4510 |
T4507 |
nummod |
1,Val |
R3072 |
T4511 |
T4507 |
punct |
",",Val |
R3073 |
T4509 |
T4507 |
punct |
(,Val |
R3074 |
T4513 |
T4507 |
punct |
),Val |
R3075 |
T4512 |
T4507 |
nummod |
16,Val |
R3076 |
T4515 |
T4508 |
punct |
;,5.8 |
R3077 |
T4516 |
T4517 |
nsubj |
p,0.03 |
R3078 |
T4514 |
T4508 |
punct |
=,5.8 |
R3079 |
T4518 |
T4517 |
punct |
=,0.03 |
R3080 |
T4519 |
T4493 |
prep |
for,7.0 |
R3081 |
T4517 |
T4508 |
conj |
0.03,5.8 |
R3082 |
T4521 |
T4519 |
pobj |
tasks,for |
R3083 |
T4522 |
T4521 |
punct |
“,tasks |
R3084 |
T4523 |
T4521 |
amod |
simple,tasks |
R3085 |
T4520 |
T4521 |
det |
the,tasks |
R3086 |
T4525 |
T4521 |
compound |
discrimination,tasks |
R3087 |
T4526 |
T4415 |
punct |
;,0.01 |
R3088 |
T4524 |
T4521 |
punct |
”,tasks |
R3089 |
T4528 |
T4530 |
compound |
way,ANOVA |
R3090 |
T4529 |
T4528 |
punct |
-,way |
R3091 |
T4530 |
T4531 |
npadvmod |
ANOVA,2.9 |
R3092 |
T4527 |
T4528 |
nummod |
3,way |
R3093 |
T4532 |
T4531 |
punct |
: ,2.9 |
R3094 |
T4531 |
T4415 |
ccomp |
2.9,0.01 |
R3095 |
T4534 |
T4533 |
punct |
(,F |
R3096 |
T4535 |
T4533 |
nummod |
6,F |
R3097 |
T4533 |
T4531 |
nsubj |
F,2.9 |
R3098 |
T4537 |
T4533 |
nummod |
96,F |
R3099 |
T4538 |
T4533 |
punct |
),F |
R3100 |
T4536 |
T4533 |
punct |
",",F |
R3101 |
T4540 |
T4415 |
punct |
;,0.01 |
R3102 |
T4541 |
T4415 |
nsubj |
p,0.01 |
R3103 |
T4539 |
T4531 |
punct |
=,2.9 |
R3104 |
T4543 |
T4415 |
punct |
),0.01 |
R3105 |
T4544 |
T4415 |
punct |
.,0.01 |
R3106 |
T4542 |
T4415 |
punct |
=,0.01 |
R3107 |
T4546 |
T4547 |
mark |
As,was |
R3108 |
T4547 |
T4556 |
advcl |
was,conclude |
R3109 |
T4549 |
T4548 |
punct |
", ",activity |
R3110 |
T4548 |
T4547 |
nsubj |
activity,was |
R3111 |
T4551 |
T4550 |
prep |
by,measured |
R3112 |
T4550 |
T4548 |
acl |
measured,activity |
R3113 |
T4553 |
T4551 |
pobj |
interval,by |
R3114 |
T4552 |
T4553 |
det |
the,interval |
R3115 |
T4555 |
T4547 |
punct |
", ",was |
R3116 |
T4557 |
T4547 |
neg |
not,was |
R3117 |
T4554 |
T4553 |
amod |
intertrial,interval |
R3118 |
T4559 |
T4547 |
acomp |
different,was |
R3119 |
T4558 |
T4559 |
advmod |
significantly,different |
R3120 |
T4561 |
T4560 |
pobj |
genotypes,between |
R3121 |
T4562 |
T4563 |
punct |
(,0.1 |
R3122 |
T4560 |
T4547 |
prep |
between,was |
R3123 |
T4564 |
T4565 |
nsubj |
F,3.1 |
R3124 |
T4565 |
T4563 |
ccomp |
3.1,0.1 |
R3126 |
T4567 |
T4564 |
nummod |
1,F |
R3127 |
T4566 |
T4564 |
punct |
(,F |
R3128 |
T4569 |
T4564 |
nummod |
16,F |
R3129 |
T4568 |
T4564 |
punct |
",",F |
R3130 |
T4571 |
T4565 |
punct |
=,3.1 |
R3131 |
T4572 |
T4563 |
punct |
;,0.1 |
R3132 |
T4570 |
T4564 |
punct |
),F |
R3133 |
T4574 |
T4563 |
punct |
=,0.1 |
R3134 |
T4575 |
T4563 |
punct |
),0.1 |
R3135 |
T4573 |
T4563 |
nsubj |
p,0.1 |
R3136 |
T4577 |
T4547 |
cc |
and,was |
R3137 |
T4578 |
T4579 |
nsubj |
analysis,showed |
R3138 |
T4576 |
T4547 |
punct |
", ",was |
R3139 |
T4580 |
T4578 |
prep |
of,analysis |
R3140 |
T4581 |
T4582 |
det |
the,frequency |
R3141 |
T4579 |
T4547 |
conj |
showed,was |
R3142 |
T4583 |
T4582 |
compound |
lick,frequency |
R3143 |
T4584 |
T4585 |
det |
a,tendency |
R3144 |
T4582 |
T4580 |
pobj |
frequency,of |
R3145 |
T4586 |
T4585 |
prep |
to,tendency |
R3146 |
T4587 |
T4588 |
amod |
reduced,motivation |
R3147 |
T4585 |
T4579 |
dobj |
tendency,showed |
R3148 |
T4589 |
T4588 |
prep |
of,motivation |
R3149 |
T4590 |
T4591 |
compound |
GluR,BΔFB |
R3150 |
T4591 |
T4593 |
compound |
BΔFB,mice |
R3151 |
T4588 |
T4586 |
pobj |
motivation,to |
R3152 |
T4593 |
T4589 |
pobj |
mice,of |
R3153 |
T4594 |
T4579 |
prep |
in,showed |
R3154 |
T4592 |
T4591 |
punct |
-,BΔFB |
R3155 |
T4596 |
T4594 |
pobj |
task,in |
R3156 |
T4597 |
T4596 |
amod |
particular,task |
R3157 |
T4595 |
T4596 |
det |
this,task |
R3158 |
T4599 |
T4579 |
parataxis |
0.01,showed |
R3159 |
T4600 |
T4601 |
nsubj |
F,9.2 |
R3160 |
T4598 |
T4599 |
punct |
(,0.01 |
R3161 |
T4602 |
T4600 |
punct |
(,F |
R3162 |
T4603 |
T4600 |
nummod |
1,F |
R3163 |
T4601 |
T4599 |
ccomp |
9.2,0.01 |
R3164 |
T4605 |
T4600 |
nummod |
16,F |
R3165 |
T4606 |
T4600 |
punct |
),F |
R3166 |
T4604 |
T4600 |
punct |
",",F |
R3167 |
T4608 |
T4599 |
punct |
;,0.01 |
R3168 |
T4607 |
T4601 |
punct |
=,9.2 |
R3169 |
T4610 |
T4599 |
punct |
<,0.01 |
R3170 |
T4611 |
T4599 |
punct |
),0.01 |
R3171 |
T4609 |
T4599 |
nsubj |
p,0.01 |
R3172 |
T4613 |
T4556 |
nsubj |
we,conclude |
R3173 |
T4612 |
T4556 |
punct |
", ",conclude |
R3174 |
T4615 |
T4556 |
ccomp |
resulted,conclude |
R3175 |
T4616 |
T4615 |
nsubj |
depletion,resulted |
R3176 |
T4614 |
T4615 |
mark |
that,resulted |
R3177 |
T4618 |
T4619 |
compound |
GluR,B |
R3178 |
T4619 |
T4617 |
pobj |
B,of |
R3179 |
T4617 |
T4616 |
prep |
of,depletion |
R3180 |
T4621 |
T4616 |
prep |
in,depletion |
R3181 |
T4622 |
T4623 |
compound |
forebrain,areas |
R3182 |
T4620 |
T4619 |
punct |
-,B |
R3183 |
T4624 |
T4615 |
advmod |
indeed,resulted |
R3184 |
T4625 |
T4615 |
prep |
in,resulted |
R3185 |
T4623 |
T4621 |
pobj |
areas,in |
R3186 |
T4627 |
T4625 |
pobj |
performances,in |
R3187 |
T4628 |
T4629 |
amod |
olfactory,learning |
R3188 |
T4626 |
T4627 |
amod |
increased,performances |
R3189 |
T4630 |
T4629 |
cc |
and,learning |
R3190 |
T4631 |
T4629 |
conj |
discrimination,learning |
R3191 |
T4629 |
T4627 |
nmod |
learning,performances |
R3192 |
T4633 |
T4634 |
advmod |
rather,than |
R3193 |
T4634 |
T4627 |
cc |
than,performances |
R3194 |
T4632 |
T4627 |
punct |
", ",performances |
R3195 |
T4636 |
T4627 |
conj |
alterations,performances |
R3196 |
T4637 |
T4556 |
punct |
.,conclude |
R3197 |
T4640 |
T4641 |
advcl |
assess,trained |
R3198 |
T4635 |
T4636 |
amod |
motivational,alterations |
R3199 |
T4643 |
T4640 |
dobj |
specificity,assess |
R3200 |
T4639 |
T4640 |
aux |
To,assess |
R3201 |
T4644 |
T4641 |
punct |
", ",trained |
R3202 |
T4642 |
T4643 |
compound |
olfaction,specificity |
R3203 |
T4646 |
T4647 |
nummod |
ten,mice |
R3204 |
T4647 |
T4641 |
dobj |
mice,trained |
R3205 |
T4645 |
T4641 |
nsubj |
we,trained |
R3206 |
T4649 |
T4647 |
compound |
BΔFB,mice |
R3207 |
T4650 |
T4649 |
punct |
-,BΔFB |
R3208 |
T4648 |
T4649 |
compound |
GluR,BΔFB |
R3209 |
T4652 |
T4653 |
nummod |
ten,controls |
R3210 |
T4651 |
T4647 |
cc |
and,mice |
R3211 |
T4654 |
T4641 |
prep |
in,trained |
R3212 |
T4653 |
T4647 |
conj |
controls,mice |
R3213 |
T4656 |
T4654 |
pobj |
task,in |
R3214 |
T4657 |
T4656 |
amod |
nonolfactory,task |
R3215 |
T4655 |
T4656 |
det |
a,task |
R3216 |
T4659 |
T4656 |
amod |
dependent,task |
R3217 |
T4660 |
T4659 |
punct |
-,dependent |
R3218 |
T4661 |
T4662 |
amod |
spatial,learning |
R3219 |
T4658 |
T4659 |
npadvmod |
hippocampus,dependent |
R3220 |
T4663 |
T4664 |
punct |
(,maze |
R3221 |
T4664 |
T4656 |
parataxis |
maze,task |
R3222 |
T4662 |
T4656 |
compound |
learning,task |
R3223 |
T4666 |
T4664 |
compound |
Y,maze |
R3224 |
T4667 |
T4664 |
punct |
-,maze |
R3225 |
T4665 |
T4664 |
amod |
elevated,maze |
R3226 |
T4669 |
T4641 |
punct |
.,trained |
R3227 |
T4668 |
T4664 |
punct |
),maze |
R3228 |
T4671 |
T4672 |
nsubjpass |
Performance,improved |
R3229 |
T4673 |
T4671 |
prep |
in,Performance |
R3230 |
T4674 |
T4675 |
det |
this,task |
R3231 |
T4675 |
T4673 |
pobj |
task,in |
R3232 |
T4672 |
T4677 |
ccomp |
improved,impaired |
R3233 |
T4678 |
T4672 |
prep |
compared,improved |
R3234 |
T4676 |
T4672 |
auxpass |
was,improved |
R3235 |
T4680 |
T4679 |
pobj |
controls,with |
R3236 |
T4681 |
T4682 |
punct |
(,S2 |
R3237 |
T4679 |
T4678 |
prep |
with,compared |
R3238 |
T4683 |
T4682 |
compound |
Figure,S2 |
R3239 |
T4682 |
T4672 |
parataxis |
S2,improved |
R3240 |
T4685 |
T4677 |
punct |
;,impaired |
R3241 |
T4686 |
T4677 |
prep |
on,impaired |
R3242 |
T4684 |
T4682 |
punct |
),S2 |
R3243 |
T4688 |
T4686 |
pobj |
contrary,on |
R3244 |
T4689 |
T4677 |
punct |
", ",impaired |
R3245 |
T4687 |
T4688 |
det |
the,contrary |
R3246 |
T4691 |
T4677 |
nsubjpass |
acquisition,impaired |
R3247 |
T4692 |
T4691 |
prep |
of,acquisition |
R3248 |
T4690 |
T4691 |
det |
the,acquisition |
R3249 |
T4694 |
T4692 |
pobj |
task,of |
R3250 |
T4695 |
T4677 |
auxpass |
was,impaired |
R3251 |
T4693 |
T4694 |
det |
this,task |
R3252 |
T4697 |
T4677 |
punct |
", ",impaired |
R3253 |
T4698 |
T4677 |
advcl |
allowing,impaired |
R3254 |
T4696 |
T4677 |
advmod |
slightly,impaired |
R3255 |
T4700 |
T4698 |
dobj |
conclusion,allowing |
R3256 |
T4699 |
T4700 |
det |
the,conclusion |
R3257 |
T4702 |
T4700 |
acl |
is,conclusion |
R3258 |
T4701 |
T4702 |
mark |
that,is |
R3259 |
T4704 |
T4703 |
amod |
enhanced,performance |
R3260 |
T4705 |
T4706 |
amod |
olfactory,discrimination |
R3261 |
T4703 |
T4702 |
nsubj |
performance,is |
R3262 |
T4707 |
T4702 |
acomp |
likely,is |
R3263 |
T4706 |
T4703 |
compound |
discrimination,performance |
R3264 |
T4709 |
T4707 |
xcomp |
be,likely |
R3265 |
T4710 |
T4709 |
acomp |
specific,be |
R3266 |
T4711 |
T4710 |
prep |
to,specific |
R3267 |
T4712 |
T4713 |
det |
the,sense |
R3268 |
T4708 |
T4709 |
aux |
to,be |
R3269 |
T4714 |
T4713 |
prep |
of,sense |
R3270 |
T4715 |
T4714 |
pobj |
smell,of |
R3271 |
T4713 |
T4711 |
pobj |
sense,to |
R3272 |
T4717 |
T4718 |
advmod |
possibly,related |
R3273 |
T4716 |
T4710 |
cc |
and,specific |
R3274 |
T4719 |
T4718 |
prep |
to,related |
R3275 |
T4720 |
T4721 |
amod |
enhanced,capability |
R3276 |
T4718 |
T4710 |
conj |
related,specific |
R3277 |
T4722 |
T4721 |
compound |
discrimination,capability |
R3278 |
T4723 |
T4721 |
punct |
", ",capability |
R3279 |
T4721 |
T4719 |
pobj |
capability,to |
R3280 |
T4725 |
T4721 |
cc |
than,capability |
R3281 |
T4726 |
T4727 |
det |
a,increase |
R3282 |
T4724 |
T4725 |
advmod |
rather,than |
R3283 |
T4728 |
T4727 |
amod |
general,increase |
R3284 |
T4727 |
T4721 |
conj |
increase,capability |
R3285 |
T4730 |
T4729 |
pobj |
alertness,in |
R3286 |
T4731 |
T4677 |
punct |
.,impaired |
R3287 |
T4729 |
T4727 |
prep |
in,increase |
R3288 |
T4733 |
T4734 |
advmod |
Furthermore,makes |
R3289 |
T4736 |
T4734 |
nsubj |
enhancement,makes |
R3290 |
T4737 |
T4736 |
prep |
in,enhancement |
R3291 |
T4735 |
T4734 |
punct |
", ",makes |
R3292 |
T4739 |
T4737 |
pobj |
discrimination,in |
R3293 |
T4740 |
T4736 |
prep |
in,enhancement |
R3294 |
T4738 |
T4739 |
compound |
odor,discrimination |
R3295 |
T4742 |
T4745 |
nmod |
BΔECS,mice |
R3296 |
T4743 |
T4742 |
nmod |
GluR,BΔECS |
R3297 |
T4741 |
T4742 |
preconj |
both,BΔECS |
R3299 |
T4746 |
T4742 |
punct |
:,BΔECS |
R3300 |
T4744 |
T4742 |
punct |
-,BΔECS |
R3301 |
T4748 |
T4749 |
compound |
GluR,BΔFB |
R3302 |
T4749 |
T4742 |
conj |
BΔFB,BΔECS |
R3303 |
T4750 |
T4749 |
punct |
-,BΔFB |
R3304 |
T4747 |
T4742 |
appos |
FB,BΔECS |
R3305 |
T4752 |
T4734 |
ccomp |
likely,makes |
R3306 |
T4753 |
T4754 |
mark |
that,results |
R3307 |
T4751 |
T4752 |
nsubj |
it,likely |
R3308 |
T4755 |
T4754 |
nsubj |
improvement,results |
R3309 |
T4756 |
T4755 |
prep |
in,improvement |
R3310 |
T4754 |
T4752 |
advcl |
results,likely |
R3311 |
T4758 |
T4756 |
pobj |
task,in |
R3312 |
T4759 |
T4754 |
prep |
from,results |
R3313 |
T4757 |
T4758 |
det |
this,task |
R3314 |
T4761 |
T4759 |
pobj |
change,from |
R3315 |
T4762 |
T4761 |
amod |
common,change |
R3316 |
T4760 |
T4761 |
det |
the,change |
R3317 |
T4764 |
T4761 |
compound |
property,change |
R3318 |
T4763 |
T4761 |
compound |
AMPAR,change |
R3319 |
T4766 |
T4765 |
agent |
by,mediated |
R3320 |
T4765 |
T4761 |
acl |
mediated,change |
R3321 |
T4768 |
T4766 |
pobj |
depletion,by |
R3322 |
T4769 |
T4768 |
prep |
of,depletion |
R3323 |
T4767 |
T4768 |
det |
the,depletion |
R3324 |
T4771 |
T4769 |
pobj |
B,of |
R3325 |
T4772 |
T4771 |
punct |
-,B |
R3326 |
T4770 |
T4771 |
compound |
GluR,B |
R3327 |
T4774 |
T4775 |
det |
the,lack |
R3328 |
T4775 |
T4768 |
conj |
lack,depletion |
R3329 |
T4773 |
T4768 |
cc |
and,depletion |
R3330 |
T4777 |
T4778 |
det |
the,subunit |
R3331 |
T4778 |
T4776 |
pobj |
subunit,of |
R3332 |
T4776 |
T4775 |
prep |
of,lack |
R3333 |
T4780 |
T4782 |
compound |
R,site |
R3334 |
T4779 |
T4780 |
compound |
Q,R |
R3335 |
T4782 |
T4783 |
npadvmod |
site,edited |
R3336 |
T4783 |
T4778 |
amod |
edited,subunit |
R3337 |
T4784 |
T4783 |
punct |
-,edited |
R3338 |
T4781 |
T4780 |
punct |
/,R |
R3339 |
T4786 |
T4778 |
compound |
B,subunit |
R3340 |
T4787 |
T4786 |
punct |
-,B |
R3341 |
T4785 |
T4786 |
compound |
GluR,B |
R3342 |
T4789 |
T4790 |
nsubj |
both,resulting |
R3343 |
T4788 |
T4754 |
punct |
", ",results |
R3344 |
T4791 |
T4790 |
prep |
in,resulting |
R3345 |
T4792 |
T4793 |
npadvmod |
Ca2,permeable |
R3346 |
T4790 |
T4754 |
advcl |
resulting,results |
R3347 |
T4794 |
T4792 |
punct |
+,Ca2 |
R3348 |
T4793 |
T4796 |
amod |
permeable,AMPARs |
R3349 |
T4796 |
T4791 |
pobj |
AMPARs,in |
R3350 |
T4797 |
T4734 |
punct |
.,makes |
R3351 |
T4795 |
T4792 |
punct |
-,Ca2 |
R3352 |
T4801 |
T4800 |
punct |
", ",suggests |
R3353 |
T4802 |
T4800 |
nsubj |
this,suggests |
R3354 |
T4799 |
T4800 |
advmod |
Thus,suggests |
R3355 |
T4804 |
T4800 |
ccomp |
leads,suggests |
R3356 |
T4805 |
T4806 |
amod |
increased,influx |
R3357 |
T4803 |
T4804 |
mark |
that,leads |
R3358 |
T4807 |
T4806 |
nmod |
Ca2,influx |
R3359 |
T4806 |
T4804 |
nsubj |
influx,leads |
R3360 |
T4809 |
T4806 |
prep |
via,influx |
R3361 |
T4810 |
T4809 |
pobj |
AMPARs,via |
R3362 |
T4808 |
T4807 |
punct |
+,Ca2 |
R3363 |
T4812 |
T4813 |
amod |
enhanced,learning |
R3364 |
T4811 |
T4804 |
prep |
to,leads |
R3365 |
T4814 |
T4813 |
amod |
olfactory,learning |
R3366 |
T4815 |
T4813 |
cc |
and,learning |
R3367 |
T4813 |
T4811 |
pobj |
learning,to |
R3368 |
T4817 |
T4800 |
punct |
.,suggests |
R3370 |
T4816 |
T4813 |
conj |
discrimination,learning |
R3376 |
T5171 |
T5172 |
amod |
Olfactory,Memory |
R3377 |
T5172 |
T5173 |
nsubj |
Memory,Is |
R3378 |
T5174 |
T5175 |
advmod |
Significantly,Decreased |
R3379 |
T5175 |
T5173 |
acomp |
Decreased,Is |
R3380 |
T5176 |
T5175 |
cc |
but,Decreased |
R3381 |
T5177 |
T5178 |
advmod |
Highly,Variable |
R3382 |
T5178 |
T5175 |
conj |
Variable,Decreased |
R3383 |
T5179 |
T5173 |
prep |
in,Is |
R3384 |
T5180 |
T5181 |
compound |
GluR,BΔFB |
R3385 |
T5181 |
T5183 |
compound |
BΔFB,Mice |
R3386 |
T5182 |
T5181 |
punct |
-,BΔFB |
R3387 |
T5183 |
T5179 |
pobj |
Mice,in |
R3388 |
T5185 |
T5186 |
aux |
To,capture |
R3389 |
T5186 |
T5187 |
advcl |
capture,assessed |
R3390 |
T5188 |
T5189 |
det |
the,extent |
R3391 |
T5189 |
T5186 |
dobj |
extent,capture |
R3392 |
T5190 |
T5189 |
amod |
full,extent |
R3393 |
T5191 |
T5189 |
prep |
of,extent |
R3394 |
T5192 |
T5193 |
det |
the,role |
R3395 |
T5193 |
T5191 |
pobj |
role,of |
R3396 |
T5194 |
T5193 |
prep |
of,role |
R3397 |
T5195 |
T5196 |
npadvmod |
Ca2,permeable |
R3398 |
T5196 |
T5199 |
amod |
permeable,AMPARs |
R3399 |
T5197 |
T5195 |
punct |
+,Ca2 |
R3400 |
T5198 |
T5196 |
punct |
-,permeable |
R3401 |
T5199 |
T5194 |
pobj |
AMPARs,of |
R3402 |
T5200 |
T5193 |
prep |
in,role |
R3403 |
T5201 |
T5202 |
amod |
olfactory,behavior |
R3404 |
T5202 |
T5200 |
pobj |
behavior,in |
R3405 |
T5203 |
T5187 |
punct |
", ",assessed |
R3406 |
T5204 |
T5187 |
nsubj |
we,assessed |
R3407 |
T5205 |
T5187 |
advmod |
next,assessed |
R3408 |
T5206 |
T5207 |
det |
the,effects |
R3409 |
T5207 |
T5187 |
dobj |
effects,assessed |
R3410 |
T5208 |
T5207 |
prep |
of,effects |
R3411 |
T5209 |
T5210 |
amod |
altered,channels |
R3412 |
T5210 |
T5208 |
pobj |
channels,of |
R3413 |
T5211 |
T5210 |
compound |
AMPA,channels |
R3414 |
T5212 |
T5207 |
prep |
on,effects |
R3415 |
T5213 |
T5214 |
amod |
olfactory,memory |
R3416 |
T5214 |
T5212 |
pobj |
memory,on |
R3417 |
T5215 |
T5187 |
punct |
.,assessed |
R3418 |
T5217 |
T5218 |
aux |
To,probe |
R3419 |
T5218 |
T5219 |
advcl |
probe,interleaved |
R3420 |
T5220 |
T5221 |
amod |
olfactory,memory |
R3421 |
T5221 |
T5218 |
dobj |
memory,probe |
R3422 |
T5222 |
T5218 |
prep |
in,probe |
R3423 |
T5223 |
T5224 |
compound |
GluR,BΔFB |
R3424 |
T5224 |
T5226 |
compound |
BΔFB,mice |
R3425 |
T5225 |
T5224 |
punct |
-,BΔFB |
R3426 |
T5226 |
T5222 |
pobj |
mice,in |
R3427 |
T5227 |
T5219 |
punct |
", ",interleaved |
R3428 |
T5228 |
T5229 |
nummod |
six,days |
R3429 |
T5229 |
T5230 |
npadvmod |
days,after |
R3430 |
T5230 |
T5219 |
prep |
after,interleaved |
R3431 |
T5231 |
T5232 |
det |
the,end |
R3432 |
T5232 |
T5230 |
pobj |
end,after |
R3433 |
T5233 |
T5232 |
prep |
of,end |
R3434 |
T5234 |
T5235 |
det |
the,phase |
R3435 |
T5235 |
T5233 |
pobj |
phase,of |
R3436 |
T5236 |
T5235 |
amod |
first,phase |
R3437 |
T5237 |
T5235 |
compound |
training,phase |
R3438 |
T5238 |
T5235 |
prep |
for,phase |
R3439 |
T5239 |
T5240 |
compound |
odor,discrimination |
R3440 |
T5240 |
T5238 |
pobj |
discrimination,for |
R3441 |
T5241 |
T5235 |
punct |
(,phase |
R3442 |
T5242 |
T5235 |
appos |
amylacetate,phase |
R3443 |
T5243 |
T5242 |
cc |
versus,amylacetate |
R3444 |
T5244 |
T5242 |
conj |
ethylbutyrate,amylacetate |
R3445 |
T5245 |
T5235 |
punct |
),phase |
R3446 |
T5246 |
T5219 |
punct |
", ",interleaved |
R3447 |
T5247 |
T5248 |
det |
the,trials |
R3448 |
T5248 |
T5219 |
nsubjpass |
trials,interleaved |
R3449 |
T5249 |
T5248 |
compound |
training,trials |
R3450 |
T5250 |
T5248 |
prep |
for,trials |
R3451 |
T5251 |
T5252 |
det |
the,pair |
R3452 |
T5252 |
T5250 |
pobj |
pair,for |
R3453 |
T5253 |
T5252 |
amod |
third,pair |
R3454 |
T5254 |
T5252 |
compound |
odor,pair |
R3455 |
T5255 |
T5252 |
punct |
(,pair |
R3456 |
T5256 |
T5257 |
amod |
pelargonic,acid |
R3457 |
T5257 |
T5252 |
appos |
acid,pair |
R3458 |
T5258 |
T5256 |
cc |
versus,pelargonic |
R3459 |
T5259 |
T5256 |
conj |
valeric,pelargonic |
R3460 |
T5260 |
T5252 |
punct |
),pair |
R3461 |
T5261 |
T5219 |
auxpass |
were,interleaved |
R3462 |
T5262 |
T5219 |
prep |
with,interleaved |
R3463 |
T5263 |
T5264 |
amod |
unrewarded,trials |
R3464 |
T5264 |
T5262 |
pobj |
trials,with |
R3465 |
T5265 |
T5266 |
prep |
in,presented |
R3466 |
T5266 |
T5264 |
relcl |
presented,trials |
R3467 |
T5267 |
T5265 |
pobj |
which,in |
R3468 |
T5268 |
T5266 |
nsubjpass |
amylacetate,presented |
R3469 |
T5269 |
T5268 |
cc |
or,amylacetate |
R3470 |
T5270 |
T5268 |
conj |
ethylbutyrate,amylacetate |
R3471 |
T5271 |
T5266 |
auxpass |
were,presented |
R3472 |
T5272 |
T5266 |
advmod |
again,presented |
R3473 |
T5273 |
T5274 |
punct |
(,bar |
R3474 |
T5274 |
T5219 |
parataxis |
bar,interleaved |
R3475 |
T5275 |
T5274 |
amod |
black,bar |
R3476 |
T5276 |
T5274 |
prep |
in,bar |
R3477 |
T5277 |
T5278 |
compound |
Figure,2C |
R3478 |
T5278 |
T5276 |
pobj |
2C,in |
R3479 |
T5279 |
T5274 |
punct |
),bar |
R3480 |
T5280 |
T5219 |
punct |
.,interleaved |
R3481 |
T5282 |
T5283 |
mark |
Whereas,responded |
R3482 |
T5283 |
T5287 |
advcl |
responded,showed |
R3483 |
T5284 |
T5285 |
compound |
control,mice |
R3484 |
T5285 |
T5283 |
nsubj |
mice,responded |
R3485 |
T5286 |
T5283 |
advmod |
reliably,responded |
R3486 |
T5288 |
T5289 |
advmod |
only,to |
R3487 |
T5289 |
T5283 |
prep |
to,responded |
R3488 |
T5290 |
T5291 |
det |
the,odor |
R3489 |
T5291 |
T5289 |
pobj |
odor,to |
R3490 |
T5292 |
T5293 |
advmod |
previously,rewarded |
R3491 |
T5293 |
T5291 |
amod |
rewarded,odor |
R3492 |
T5294 |
T5295 |
punct |
(,2E |
R3493 |
T5295 |
T5291 |
parataxis |
2E,odor |
R3494 |
T5296 |
T5295 |
dep |
memory,2E |
R3495 |
T5297 |
T5296 |
prep |
of,memory |
R3496 |
T5298 |
T5299 |
quantmod |
86,8 |
R3497 |
T5299 |
T5301 |
nummod |
8,% |
R3498 |
T5300 |
T5299 |
punct |
±,8 |
R3499 |
T5301 |
T5297 |
pobj |
%,of |
R3500 |
T5302 |
T5295 |
punct |
", ",2E |
R3501 |
T5303 |
T5304 |
nmod |
mean,SD |
R3502 |
T5304 |
T5295 |
dep |
SD,2E |
R3503 |
T5305 |
T5304 |
punct |
±,SD |
R3504 |
T5306 |
T5295 |
punct |
", ",2E |
R3505 |
T5307 |
T5308 |
nsubj |
n,9 |
R3506 |
T5308 |
T5295 |
ccomp |
9,2E |
R3507 |
T5309 |
T5308 |
punct |
=,9 |
R3508 |
T5310 |
T5295 |
punct |
", ",2E |
R3509 |
T5311 |
T5295 |
compound |
Figure,2E |
R3510 |
T5312 |
T5295 |
punct |
),2E |
R3511 |
T5313 |
T5287 |
punct |
", ",showed |
R3512 |
T5314 |
T5315 |
compound |
GluR,BΔFB |
R3513 |
T5315 |
T5317 |
compound |
BΔFB,mice |
R3514 |
T5316 |
T5315 |
punct |
-,BΔFB |
R3515 |
T5317 |
T5287 |
nsubj |
mice,showed |
R3516 |
T5318 |
T5319 |
amod |
reduced,memory |
R3517 |
T5319 |
T5287 |
dobj |
memory,showed |
R3518 |
T5320 |
T5319 |
amod |
olfactory,memory |
R3519 |
T5321 |
T5322 |
punct |
(,Whitney |
R3520 |
T5322 |
T5287 |
parataxis |
Whitney,showed |
R3521 |
T5323 |
T5324 |
quantmod |
69,16 |
R3522 |
T5324 |
T5326 |
nummod |
16,% |
R3523 |
T5325 |
T5324 |
punct |
±,16 |
R3524 |
T5326 |
T5322 |
dep |
%,Whitney |
R3525 |
T5327 |
T5322 |
punct |
", ",Whitney |
R3526 |
T5328 |
T5329 |
nsubj |
n,9 |
R3527 |
T5329 |
T5322 |
ccomp |
9,Whitney |
R3528 |
T5330 |
T5329 |
punct |
=,9 |
R3529 |
T5331 |
T5322 |
punct |
", ",Whitney |
R3530 |
T5332 |
T5333 |
nsubj |
p,0.05 |
R3531 |
T5333 |
T5322 |
ccomp |
0.05,Whitney |
R3532 |
T5334 |
T5333 |
punct |
<,0.05 |
R3533 |
T5335 |
T5322 |
punct |
", ",Whitney |
R3534 |
T5336 |
T5322 |
compound |
Mann,Whitney |
R3535 |
T5337 |
T5322 |
punct |
-,Whitney |
R3536 |
T5338 |
T5322 |
punct |
),Whitney |
R3537 |
T5339 |
T5287 |
punct |
.,showed |
R3538 |
T5341 |
T5342 |
prep |
Due,speculate |
R3539 |
T5343 |
T5341 |
pcomp |
to,Due |
R3540 |
T5344 |
T5345 |
det |
the,learning |
R3541 |
T5345 |
T5341 |
pobj |
learning,Due |
R3542 |
T5346 |
T5347 |
advmod |
more,rapid |
R3543 |
T5347 |
T5345 |
amod |
rapid,learning |
R3544 |
T5348 |
T5345 |
acl |
observed,learning |
R3545 |
T5349 |
T5348 |
prep |
in,observed |
R3546 |
T5350 |
T5351 |
compound |
GluR,BΔFB |
R3547 |
T5351 |
T5349 |
pobj |
BΔFB,in |
R3548 |
T5352 |
T5351 |
punct |
-,BΔFB |
R3549 |
T5353 |
T5342 |
punct |
", ",speculate |
R3550 |
T5354 |
T5342 |
nsubj |
one,speculate |
R3551 |
T5355 |
T5342 |
aux |
could,speculate |
R3552 |
T5356 |
T5357 |
mark |
that,reflect |
R3553 |
T5357 |
T5342 |
ccomp |
reflect,speculate |
R3554 |
T5358 |
T5359 |
det |
a,decrease |
R3555 |
T5359 |
T5357 |
nsubj |
decrease,reflect |
R3556 |
T5360 |
T5359 |
prep |
in,decrease |
R3557 |
T5361 |
T5362 |
amod |
olfactory,memory |
R3558 |
T5362 |
T5360 |
pobj |
memory,in |
R3559 |
T5363 |
T5357 |
aux |
might,reflect |
R3560 |
T5364 |
T5357 |
advmod |
simply,reflect |
R3561 |
T5365 |
T5366 |
amod |
increased,extinction |
R3562 |
T5366 |
T5357 |
dobj |
extinction,reflect |
R3563 |
T5367 |
T5342 |
punct |
.,speculate |
R3564 |
T5369 |
T5370 |
advmod |
However,were |
R3565 |
T5371 |
T5370 |
punct |
", ",were |
R3566 |
T5372 |
T5373 |
compound |
extinction,levels |
R3567 |
T5373 |
T5370 |
nsubj |
levels,were |
R3568 |
T5374 |
T5370 |
acomp |
low,were |
R3569 |
T5375 |
T5370 |
prep |
in,were |
R3570 |
T5376 |
T5375 |
amod |
general,in |
R3571 |
T5377 |
T5370 |
punct |
", ",were |
R3572 |
T5378 |
T5379 |
det |
no,interaction |
R3573 |
T5379 |
T5384 |
nsubjpass |
interaction,found |
R3574 |
T5380 |
T5379 |
amod |
significant,interaction |
R3575 |
T5381 |
T5382 |
nmod |
group,trial |
R3576 |
T5382 |
T5379 |
compound |
trial,interaction |
R3577 |
T5383 |
T5382 |
punct |
-,trial |
R3578 |
T5384 |
T5370 |
conj |
found,were |
R3579 |
T5385 |
T5384 |
aux |
could,found |
R3580 |
T5386 |
T5384 |
auxpass |
be,found |
R3581 |
T5387 |
T5384 |
prep |
for,found |
R3582 |
T5388 |
T5389 |
det |
the,trials |
R3583 |
T5389 |
T5387 |
pobj |
trials,for |
R3584 |
T5390 |
T5389 |
compound |
memory,trials |
R3585 |
T5391 |
T5392 |
punct |
(,ANOVA |
R3586 |
T5392 |
T5384 |
parataxis |
ANOVA,found |
R3587 |
T5393 |
T5394 |
nummod |
2,way |
R3588 |
T5394 |
T5392 |
compound |
way,ANOVA |
R3589 |
T5395 |
T5394 |
punct |
-,way |
R3590 |
T5396 |
T5392 |
punct |
", ",ANOVA |
R3591 |
T5397 |
T5398 |
nsubj |
F,1.5 |
R3592 |
T5398 |
T5392 |
ccomp |
1.5,ANOVA |
R3593 |
T5399 |
T5397 |
punct |
(,F |
R3594 |
T5400 |
T5397 |
nummod |
6,F |
R3595 |
T5401 |
T5397 |
punct |
",",F |
R3596 |
T5402 |
T5397 |
nummod |
90,F |
R3597 |
T5403 |
T5397 |
punct |
),F |
R3598 |
T5404 |
T5398 |
punct |
=,1.5 |
R3599 |
T5405 |
T5392 |
punct |
", ",ANOVA |
R3600 |
T5406 |
T5407 |
nsubj |
p,0.1 |
R3601 |
T5407 |
T5392 |
ccomp |
0.1,ANOVA |
R3602 |
T5408 |
T5407 |
punct |
>,0.1 |
R3603 |
T5409 |
T5392 |
punct |
),ANOVA |
R3604 |
T5410 |
T5384 |
punct |
", ",found |
R3605 |
T5411 |
T5384 |
cc |
and,found |
R3606 |
T5412 |
T5413 |
det |
a,restriction |
R3607 |
T5413 |
T5414 |
nsubj |
restriction,displayed |
R3608 |
T5414 |
T5384 |
conj |
displayed,found |
R3609 |
T5415 |
T5413 |
prep |
of,restriction |
R3610 |
T5416 |
T5417 |
det |
the,analysis |
R3611 |
T5417 |
T5415 |
pobj |
analysis,of |
R3612 |
T5418 |
T5413 |
prep |
to,restriction |
R3613 |
T5419 |
T5420 |
amod |
early,trials |
R3614 |
T5420 |
T5418 |
pobj |
trials,to |
R3615 |
T5421 |
T5420 |
compound |
memory,trials |
R3616 |
T5422 |
T5423 |
advmod |
essentially,pattern |
R3617 |
T5423 |
T5414 |
dobj |
pattern,displayed |
R3618 |
T5424 |
T5423 |
det |
the,pattern |
R3619 |
T5425 |
T5423 |
amod |
same,pattern |
R3620 |
T5426 |
T5427 |
punct |
(,S3A |
R3621 |
T5427 |
T5414 |
parataxis |
S3A,displayed |
R3622 |
T5428 |
T5427 |
compound |
Figure,S3A |
R3623 |
T5429 |
T5427 |
punct |
),S3A |
R3624 |
T5430 |
T5370 |
punct |
.,were |
R3625 |
T5432 |
T5433 |
advmod |
Thus,is |
R3626 |
T5434 |
T5433 |
punct |
", ",is |
R3627 |
T5435 |
T5436 |
amod |
reduced,performance |
R3628 |
T5436 |
T5433 |
nsubj |
performance,is |
R3629 |
T5437 |
T5436 |
prep |
in,performance |
R3630 |
T5438 |
T5439 |
det |
the,trials |
R3631 |
T5439 |
T5437 |
pobj |
trials,in |
R3632 |
T5440 |
T5439 |
compound |
probe,trials |
R3633 |
T5441 |
T5433 |
neg |
not,is |
R3634 |
T5442 |
T5433 |
prep |
due,is |
R3635 |
T5443 |
T5442 |
pcomp |
to,due |
R3636 |
T5444 |
T5445 |
amod |
increased,extinction |
R3637 |
T5445 |
T5442 |
pobj |
extinction,due |
R3638 |
T5446 |
T5433 |
cc |
but,is |
R3639 |
T5447 |
T5433 |
conj |
reflects,is |
R3640 |
T5448 |
T5449 |
amod |
genuine,impairment |
R3641 |
T5449 |
T5447 |
dobj |
impairment,reflects |
R3642 |
T5450 |
T5449 |
compound |
memory,impairment |
R3643 |
T5451 |
T5433 |
punct |
.,is |
R3644 |
T5453 |
T5454 |
advmod |
Moreover,conclude |
R3645 |
T5455 |
T5454 |
punct |
", ",conclude |
R3646 |
T5456 |
T5457 |
mark |
because,affected |
R3647 |
T5457 |
T5454 |
advcl |
affected,conclude |
R3648 |
T5458 |
T5459 |
det |
the,acquisition |
R3649 |
T5459 |
T5457 |
nsubjpass |
acquisition,affected |
R3650 |
T5460 |
T5461 |
npadvmod |
hippocampus,dependent |
R3651 |
T5461 |
T5459 |
amod |
dependent,acquisition |
R3652 |
T5462 |
T5461 |
punct |
-,dependent |
R3653 |
T5463 |
T5459 |
amod |
spatial,acquisition |
R3654 |
T5464 |
T5459 |
nmod |
memory,acquisition |
R3655 |
T5465 |
T5466 |
nmod |
after,task |
R3656 |
T5466 |
T5459 |
compound |
task,acquisition |
R3657 |
T5467 |
T5466 |
punct |
-,task |
R3658 |
T5468 |
T5459 |
prep |
in,acquisition |
R3659 |
T5469 |
T5470 |
det |
the,maze |
R3660 |
T5470 |
T5468 |
pobj |
maze,in |
R3661 |
T5471 |
T5470 |
compound |
Y,maze |
R3662 |
T5472 |
T5470 |
punct |
-,maze |
R3663 |
T5473 |
T5457 |
auxpass |
was,affected |
R3664 |
T5474 |
T5457 |
neg |
not,affected |
R3665 |
T5475 |
T5476 |
punct |
(,S2 |
R3666 |
T5476 |
T5457 |
parataxis |
S2,affected |
R3667 |
T5477 |
T5476 |
compound |
Figure,S2 |
R3668 |
T5478 |
T5476 |
punct |
),S2 |
R3669 |
T5479 |
T5454 |
punct |
", ",conclude |
R3670 |
T5480 |
T5454 |
nsubj |
we,conclude |
R3671 |
T5481 |
T5482 |
mark |
that,is |
R3672 |
T5482 |
T5454 |
ccomp |
is,conclude |
R3673 |
T5483 |
T5484 |
det |
the,deficit |
R3674 |
T5484 |
T5482 |
nsubj |
deficit,is |
R3675 |
T5485 |
T5484 |
amod |
observed,deficit |
R3676 |
T5486 |
T5487 |
amod |
olfactory,memory |
R3677 |
T5487 |
T5484 |
compound |
memory,deficit |
R3678 |
T5488 |
T5489 |
advmod |
rather,specific |
R3679 |
T5489 |
T5482 |
acomp |
specific,is |
R3680 |
T5490 |
T5489 |
prep |
for,specific |
R3681 |
T5491 |
T5490 |
pobj |
olfaction,for |
R3682 |
T5492 |
T5482 |
cc |
and,is |
R3683 |
T5493 |
T5494 |
aux |
does,generalize |
R3684 |
T5494 |
T5482 |
conj |
generalize,is |
R3685 |
T5495 |
T5494 |
neg |
not,generalize |
R3686 |
T5496 |
T5494 |
advmod |
readily,generalize |
R3687 |
T5497 |
T5494 |
prep |
to,generalize |
R3688 |
T5498 |
T5499 |
amod |
other,modalities |
R3689 |
T5499 |
T5497 |
pobj |
modalities,to |
R3690 |
T5500 |
T5454 |
punct |
.,conclude |
R3691 |
T5502 |
T5503 |
mark |
While,showed |
R3692 |
T5503 |
T5511 |
advcl |
showed,was |
R3693 |
T5504 |
T5505 |
det |
the,behavior |
R3694 |
T5505 |
T5503 |
nsubj |
behavior,showed |
R3695 |
T5506 |
T5505 |
amod |
improved,behavior |
R3696 |
T5507 |
T5508 |
nmod |
odor,discrimination |
R3697 |
T5508 |
T5505 |
nmod |
discrimination,behavior |
R3698 |
T5509 |
T5508 |
cc |
and,discrimination |
R3699 |
T5510 |
T5508 |
conj |
learning,discrimination |
R3700 |
T5512 |
T5513 |
advmod |
only,variability |
R3701 |
T5513 |
T5503 |
dobj |
variability,showed |
R3702 |
T5514 |
T5513 |
amod |
little,variability |
R3703 |
T5515 |
T5511 |
punct |
", ",was |
R3704 |
T5516 |
T5517 |
det |
the,performance |
R3705 |
T5517 |
T5511 |
nsubj |
performance,was |
R3706 |
T5518 |
T5519 |
advmod |
significantly,impaired |
R3707 |
T5519 |
T5517 |
amod |
impaired,performance |
R3708 |
T5520 |
T5517 |
compound |
memory,performance |
R3709 |
T5521 |
T5517 |
acl |
observed,performance |
R3710 |
T5522 |
T5521 |
prep |
in,observed |
R3711 |
T5523 |
T5524 |
compound |
GluR,BΔFB |
R3712 |
T5524 |
T5526 |
compound |
BΔFB,mice |
R3713 |
T5525 |
T5524 |
punct |
-,BΔFB |
R3714 |
T5526 |
T5522 |
pobj |
mice,in |
R3715 |
T5527 |
T5528 |
advmod |
highly,variable |
R3716 |
T5528 |
T5511 |
acomp |
variable,was |
R3717 |
T5529 |
T5511 |
prep |
among,was |
R3718 |
T5530 |
T5531 |
amod |
individual,animals |
R3719 |
T5531 |
T5529 |
pobj |
animals,among |
R3720 |
T5532 |
T5511 |
prep |
compared,was |
R3721 |
T5533 |
T5532 |
prep |
with,compared |
R3722 |
T5534 |
T5535 |
compound |
control,littermates |
R3723 |
T5535 |
T5533 |
pobj |
littermates,with |
R3724 |
T5536 |
T5537 |
punct |
(,2E |
R3725 |
T5537 |
T5511 |
parataxis |
2E,was |
R3726 |
T5538 |
T5537 |
compound |
Figure,2E |
R3727 |
T5539 |
T5537 |
punct |
),2E |
R3728 |
T5540 |
T5511 |
punct |
.,was |
R3729 |
T5542 |
T5543 |
det |
This,variability |
R3730 |
T5543 |
T5544 |
nsubjpass |
variability,reflected |
R3731 |
T5545 |
T5543 |
prep |
in,variability |
R3732 |
T5546 |
T5547 |
amod |
olfactory,memory |
R3733 |
T5547 |
T5545 |
pobj |
memory,in |
R3734 |
T5548 |
T5544 |
auxpass |
was,reflected |
R3735 |
T5549 |
T5544 |
prep |
in,reflected |
R3736 |
T5550 |
T5551 |
det |
the,level |
R3737 |
T5551 |
T5549 |
pobj |
level,in |
R3738 |
T5552 |
T5551 |
cc |
and,level |
R3739 |
T5553 |
T5551 |
conj |
extent,level |
R3740 |
T5554 |
T5551 |
prep |
of,level |
R3741 |
T5555 |
T5556 |
compound |
Cre,recombinase |
R3742 |
T5556 |
T5558 |
compound |
recombinase,expression |
R3743 |
T5557 |
T5556 |
punct |
-,recombinase |
R3744 |
T5558 |
T5554 |
pobj |
expression,of |
R3745 |
T5559 |
T5544 |
prep |
in,reflected |
R3746 |
T5560 |
T5559 |
pobj |
forebrain,in |
R3747 |
T5561 |
T5560 |
prep |
of,forebrain |
R3748 |
T5562 |
T5563 |
amod |
transgenic,mice |
R3749 |
T5563 |
T5561 |
pobj |
mice,of |
R3750 |
T5564 |
T5563 |
compound |
TgCre4,mice |
R3751 |
T5565 |
T5544 |
punct |
", ",reflected |
R3752 |
T5566 |
T5567 |
mark |
as,visualized |
R3753 |
T5567 |
T5544 |
advcl |
visualized,reflected |
R3754 |
T5568 |
T5567 |
prep |
by,visualized |
R3755 |
T5569 |
T5570 |
compound |
Cre,activity |
R3756 |
T5570 |
T5568 |
pobj |
activity,by |
R3757 |
T5571 |
T5570 |
punct |
-,activity |
R3758 |
T5572 |
T5567 |
prep |
in,visualized |
R3759 |
T5573 |
T5574 |
det |
the,line |
R3760 |
T5574 |
T5572 |
pobj |
line,in |
R3761 |
T5575 |
T5576 |
compound |
Cre,indicator |
R3762 |
T5576 |
T5574 |
compound |
indicator,line |
R3763 |
T5577 |
T5576 |
punct |
-,indicator |
R3764 |
T5578 |
T5574 |
compound |
mouse,line |
R3765 |
T5579 |
T5574 |
appos |
R26R,line |
R3766 |
T5580 |
T5544 |
punct |
.,reflected |
R3767 |
T5582 |
T5583 |
nsubj |
We,observed |
R3768 |
T5584 |
T5585 |
mark |
that,varied |
R3770 |
T5586 |
T5585 |
nsubj |
onset,varied |
R3771 |
T5587 |
T5586 |
cc |
and,onset |
R3772 |
T5588 |
T5586 |
conj |
extent,onset |
R3773 |
T5589 |
T5586 |
prep |
of,onset |
R3774 |
T5590 |
T5591 |
compound |
Cre,recombinase |
R3775 |
T5591 |
T5593 |
compound |
recombinase,expression |
R3776 |
T5592 |
T5591 |
punct |
-,recombinase |
R3777 |
T5593 |
T5589 |
pobj |
expression,of |
R3778 |
T5594 |
T5593 |
prep |
in,expression |
R3779 |
T5595 |
T5596 |
amod |
different,regions |
R3780 |
T5596 |
T5594 |
pobj |
regions,in |
R3781 |
T5597 |
T5596 |
compound |
forebrain,regions |
R3782 |
T5598 |
T5585 |
prep |
among,varied |
R3783 |
T5599 |
T5600 |
amod |
individual,mice |
R3784 |
T5600 |
T5598 |
pobj |
mice,among |
R3785 |
T5601 |
T5600 |
compound |
TgCre4,mice |
R3786 |
T5602 |
T5603 |
punct |
(,3A |
R3787 |
T5603 |
T5585 |
parataxis |
3A,varied |
R3788 |
T5604 |
T5603 |
compound |
Figure,3A |
R3789 |
T5605 |
T5603 |
punct |
),3A |
R3790 |
T5606 |
T5583 |
punct |
", ",observed |
R3791 |
T5607 |
T5608 |
dep |
which,visualized |
R3792 |
T5608 |
T5583 |
advcl |
visualized,observed |
R3793 |
T5609 |
T5608 |
aux |
could,visualized |
R3794 |
T5610 |
T5608 |
advmod |
also,visualized |
R3795 |
T5611 |
T5608 |
auxpass |
be,visualized |
R3796 |
T5612 |
T5608 |
advmod |
directly,visualized |
R3797 |
T5613 |
T5608 |
prep |
by,visualized |
R3798 |
T5614 |
T5613 |
pobj |
immunohistochemistry,by |
R3799 |
T5615 |
T5608 |
prep |
with,visualized |
R3800 |
T5616 |
T5617 |
det |
a,antibody |
R3801 |
T5617 |
T5615 |
pobj |
antibody,with |
R3802 |
T5618 |
T5617 |
compound |
Cre,antibody |
R3803 |
T5619 |
T5617 |
punct |
-,antibody |
R3804 |
T5620 |
T5621 |
punct |
(,data |
R3805 |
T5621 |
T5583 |
meta |
data,observed |
R3806 |
T5622 |
T5621 |
amod |
unpublished,data |
R3807 |
T5623 |
T5621 |
punct |
),data |
R3808 |
T5624 |
T5583 |
punct |
.,observed |
R3809 |
T5626 |
T5627 |
mark |
As,persisted |
R3810 |
T5627 |
T5630 |
advcl |
persisted,attributed |
R3811 |
T5628 |
T5629 |
det |
this,variability |
R3812 |
T5629 |
T5627 |
nsubj |
variability,persisted |
R3813 |
T5631 |
T5627 |
prep |
after,persisted |
R3814 |
T5632 |
T5633 |
amod |
several,backcrosses |
R3815 |
T5633 |
T5631 |
pobj |
backcrosses,after |
R3816 |
T5634 |
T5627 |
punct |
", ",persisted |
R3817 |
T5635 |
T5627 |
cc |
and,persisted |
R3818 |
T5636 |
T5637 |
compound |
Southern,blot |
R3819 |
T5637 |
T5638 |
compound |
blot,analysis |
R3820 |
T5638 |
T5639 |
nsubj |
analysis,revealed |
R3821 |
T5639 |
T5627 |
conj |
revealed,persisted |
R3822 |
T5640 |
T5641 |
det |
no,differences |
R3823 |
T5641 |
T5639 |
dobj |
differences,revealed |
R3824 |
T5642 |
T5641 |
prep |
of,differences |
R3825 |
T5643 |
T5644 |
compound |
transgene,integration |
R3826 |
T5644 |
T5642 |
pobj |
integration,of |
R3827 |
T5645 |
T5644 |
cc |
or,integration |
R3828 |
T5646 |
T5644 |
conj |
number,integration |
R3829 |
T5647 |
T5641 |
prep |
among,differences |
R3830 |
T5648 |
T5647 |
pobj |
animals,among |
R3831 |
T5649 |
T5650 |
punct |
(,3B |
R3832 |
T5650 |
T5639 |
parataxis |
3B,revealed |
R3833 |
T5651 |
T5650 |
compound |
Figure,3B |
R3834 |
T5652 |
T5650 |
punct |
),3B |
R3835 |
T5653 |
T5630 |
punct |
", ",attributed |
R3836 |
T5654 |
T5630 |
nsubjpass |
it,attributed |
R3837 |
T5655 |
T5630 |
aux |
could,attributed |
R3838 |
T5656 |
T5630 |
neg |
not,attributed |
R3839 |
T5657 |
T5630 |
auxpass |
be,attributed |
R3840 |
T5658 |
T5630 |
prep |
to,attributed |
R3841 |
T5659 |
T5660 |
amod |
genetic,differences |
R3842 |
T5660 |
T5658 |
pobj |
differences,to |
R3843 |
T5661 |
T5658 |
cc |
but,to |
R3844 |
T5662 |
T5661 |
advmod |
rather,but |
R3845 |
T5663 |
T5658 |
conj |
to,to |
R3846 |
T5664 |
T5665 |
amod |
epigenetic,mechanisms |
R3847 |
T5665 |
T5663 |
pobj |
mechanisms,to |
R3848 |
T5666 |
T5630 |
punct |
.,attributed |
R3849 |
T5668 |
T5669 |
advmod |
Hence,hypothesized |
R3850 |
T5670 |
T5669 |
punct |
", ",hypothesized |
R3851 |
T5671 |
T5669 |
nsubj |
we,hypothesized |
R3852 |
T5672 |
T5673 |
mark |
that,reflected |
R3853 |
T5673 |
T5669 |
ccomp |
reflected,hypothesized |
R3854 |
T5674 |
T5675 |
det |
the,variability |
R3855 |
T5675 |
T5673 |
nsubj |
variability,reflected |
R3856 |
T5676 |
T5675 |
prep |
in,variability |
R3857 |
T5677 |
T5678 |
amod |
olfactory,memory |
R3858 |
T5678 |
T5676 |
pobj |
memory,in |
R3859 |
T5679 |
T5680 |
det |
the,mosaicism |
R3860 |
T5680 |
T5673 |
dobj |
mosaicism,reflected |
R3861 |
T5681 |
T5680 |
acl |
observed,mosaicism |
R3862 |
T5682 |
T5681 |
prep |
in,observed |
R3863 |
T5683 |
T5684 |
det |
the,line |
R3864 |
T5684 |
T5682 |
pobj |
line,in |
R3865 |
T5685 |
T5684 |
amod |
transgenic,line |
R3866 |
T5686 |
T5684 |
compound |
TgCre4,line |
R3867 |
T5687 |
T5669 |
punct |
.,hypothesized |
R3868 |
T5689 |
T5690 |
det |
The,evaluation |
R3869 |
T5690 |
T5691 |
nsubjpass |
evaluation,applied |
R3870 |
T5692 |
T5690 |
prep |
of,evaluation |
R3871 |
T5693 |
T5694 |
amod |
regional,differences |
R3872 |
T5694 |
T5692 |
pobj |
differences,of |
R3873 |
T5695 |
T5694 |
prep |
in,differences |
R3874 |
T5696 |
T5697 |
compound |
expression,pattern |
R3875 |
T5697 |
T5695 |
pobj |
pattern,in |
R3876 |
T5698 |
T5697 |
prep |
of,pattern |
R3877 |
T5699 |
T5698 |
pobj |
animals,of |
R3878 |
T5700 |
T5699 |
prep |
with,animals |
R3879 |
T5701 |
T5702 |
amod |
robust,memory |
R3880 |
T5702 |
T5700 |
pobj |
memory,with |
R3881 |
T5703 |
T5701 |
cc |
and,robust |
R3882 |
T5704 |
T5701 |
conj |
poor,robust |
R3883 |
T5705 |
T5702 |
amod |
olfactory,memory |
R3884 |
T5706 |
T5691 |
aux |
could,applied |
R3885 |
T5707 |
T5691 |
advmod |
then,applied |
R3886 |
T5708 |
T5691 |
auxpass |
be,applied |
R3887 |
T5709 |
T5710 |
aux |
to,identify |
R3888 |
T5710 |
T5691 |
advcl |
identify,applied |
R3889 |
T5711 |
T5712 |
compound |
brain,areas |
R3890 |
T5712 |
T5710 |
dobj |
areas,identify |
R3891 |
T5713 |
T5712 |
amod |
responsible,areas |
R3892 |
T5714 |
T5713 |
prep |
for,responsible |
R3893 |
T5715 |
T5716 |
det |
the,phenotypes |
R3894 |
T5716 |
T5714 |
pobj |
phenotypes,for |
R3895 |
T5717 |
T5716 |
amod |
observed,phenotypes |
R3896 |
T5718 |
T5691 |
punct |
.,applied |
R3899 |
T5967 |
T5968 |
amod |
Olfactory,Memory |
R3900 |
T5968 |
T5969 |
nsubj |
Memory,Correlates |
R3901 |
T5970 |
T5969 |
prep |
with,Correlates |
R3902 |
T5971 |
T5972 |
amod |
Residual,Expression |
R3903 |
T5972 |
T5970 |
pobj |
Expression,with |
R3904 |
T5973 |
T5974 |
compound |
GluR,B |
R3905 |
T5974 |
T5972 |
compound |
B,Expression |
R3906 |
T5975 |
T5974 |
punct |
-,B |
R3907 |
T5976 |
T5972 |
compound |
Protein,Expression |
R3908 |
T5977 |
T5969 |
prep |
in,Correlates |
R3909 |
T5978 |
T5979 |
compound |
GluR,BΔFB |
R3910 |
T5979 |
T5981 |
compound |
BΔFB,Mice |
R3911 |
T5980 |
T5979 |
punct |
-,BΔFB |
R3912 |
T5981 |
T5977 |
pobj |
Mice,in |
R3913 |
T5983 |
T5984 |
advmod |
Thus,analyzed |
R3914 |
T5985 |
T5984 |
punct |
", ",analyzed |
R3915 |
T5986 |
T5987 |
aux |
to,examine |
R3916 |
T5987 |
T5984 |
advcl |
examine,analyzed |
R3917 |
T5988 |
T5989 |
mark |
whether,reflects |
R3918 |
T5989 |
T5987 |
ccomp |
reflects,examine |
R3919 |
T5990 |
T5991 |
det |
the,variability |
R3920 |
T5991 |
T5989 |
nsubj |
variability,reflects |
R3921 |
T5992 |
T5991 |
amod |
pronounced,variability |
R3922 |
T5993 |
T5991 |
prep |
of,variability |
R3923 |
T5994 |
T5995 |
amod |
olfactory,memory |
R3924 |
T5995 |
T5993 |
pobj |
memory,of |
R3925 |
T5996 |
T5991 |
prep |
in,variability |
R3926 |
T5997 |
T5998 |
compound |
GluR,BΔFB |
R3927 |
T5998 |
T6000 |
compound |
BΔFB,mice |
R3928 |
T5999 |
T5998 |
punct |
-,BΔFB |
R3929 |
T6000 |
T5996 |
pobj |
mice,in |
R3930 |
T6001 |
T6002 |
punct |
(,2E |
R3931 |
T6002 |
T5991 |
parataxis |
2E,variability |
R3932 |
T6003 |
T6002 |
compound |
Figure,2E |
R3933 |
T6004 |
T6002 |
punct |
),2E |
R3934 |
T6005 |
T5989 |
dobj |
variability,reflects |
R3935 |
T6006 |
T6005 |
prep |
of,variability |
R3936 |
T6007 |
T6008 |
compound |
GluR,B |
R3937 |
T6008 |
T6010 |
compound |
B,levels |
R3938 |
T6009 |
T6008 |
punct |
-,B |
R3939 |
T6010 |
T6006 |
pobj |
levels,of |
R3940 |
T6011 |
T6005 |
prep |
in,variability |
R3941 |
T6012 |
T6013 |
compound |
GluR,BΔFB |
R3942 |
T6013 |
T6015 |
compound |
BΔFB,mice |
R3943 |
T6014 |
T6013 |
punct |
-,BΔFB |
R3944 |
T6015 |
T6011 |
pobj |
mice,in |
R3945 |
T6016 |
T5984 |
punct |
", ",analyzed |
R3946 |
T6017 |
T5984 |
nsubj |
we,analyzed |
R3947 |
T6018 |
T6019 |
det |
the,amount |
R3948 |
T6019 |
T5984 |
dobj |
amount,analyzed |
R3949 |
T6020 |
T6019 |
amod |
residual,amount |
R3950 |
T6021 |
T6019 |
prep |
of,amount |
R3951 |
T6022 |
T6023 |
compound |
GluR,B |
R3952 |
T6023 |
T6025 |
compound |
B,protein |
R3953 |
T6024 |
T6023 |
punct |
-,B |
R3954 |
T6025 |
T6021 |
pobj |
protein,of |
R3955 |
T6026 |
T6019 |
prep |
in,amount |
R3956 |
T6027 |
T6026 |
pobj |
mice,in |
R3957 |
T6028 |
T6027 |
prep |
with,mice |
R3958 |
T6029 |
T6030 |
amod |
disparate,performances |
R3959 |
T6030 |
T6028 |
pobj |
performances,with |
R3960 |
T6031 |
T6030 |
compound |
memory,performances |
R3961 |
T6032 |
T6033 |
punct |
(,4A |
R3962 |
T6033 |
T6019 |
parataxis |
4A,amount |
R3963 |
T6034 |
T6033 |
compound |
Figure,4A |
R3964 |
T6035 |
T6036 |
punct |
–,C |
R3965 |
T6036 |
T6033 |
prep |
C,4A |
R3966 |
T6037 |
T6033 |
punct |
),4A |
R3967 |
T6038 |
T5984 |
punct |
.,analyzed |
R3968 |
T6040 |
T6041 |
advmod |
Notably,showed |
R3969 |
T6042 |
T6041 |
punct |
", ",showed |
R3970 |
T6043 |
T6041 |
nsubj |
mice,showed |
R3971 |
T6044 |
T6043 |
prep |
with,mice |
R3972 |
T6045 |
T6046 |
amod |
pronounced,deficits |
R3973 |
T6046 |
T6044 |
pobj |
deficits,with |
R3974 |
T6047 |
T6046 |
compound |
memory,deficits |
R3975 |
T6048 |
T6049 |
punct |
(,% |
R3976 |
T6049 |
T6043 |
parataxis |
%,mice |
R3977 |
T6050 |
T6049 |
nsubj |
memory,% |
R3978 |
T6051 |
T6049 |
punct |
<,% |
R3979 |
T6052 |
T6049 |
nummod |
70,% |
R3980 |
T6053 |
T6049 |
punct |
),% |
R3981 |
T6054 |
T6055 |
advmod |
essentially,protein |
R3982 |
T6055 |
T6041 |
dobj |
protein,showed |
R3983 |
T6056 |
T6055 |
det |
no,protein |
R3984 |
T6057 |
T6055 |
amod |
detectable,protein |
R3985 |
T6058 |
T6059 |
compound |
GluR,B |
R3986 |
T6059 |
T6055 |
compound |
B,protein |
R3987 |
T6060 |
T6059 |
punct |
-,B |
R3988 |
T6061 |
T6041 |
prep |
in,showed |
R3989 |
T6062 |
T6061 |
pobj |
hippocampus,in |
R3990 |
T6063 |
T6062 |
punct |
", ",hippocampus |
R3991 |
T6064 |
T6062 |
conj |
amygdala,hippocampus |
R3992 |
T6065 |
T6064 |
punct |
", ",amygdala |
R3993 |
T6066 |
T6067 |
amod |
olfactory,bulb |
R3994 |
T6067 |
T6064 |
conj |
bulb,amygdala |
R3995 |
T6068 |
T6067 |
punct |
", ",bulb |
R3996 |
T6069 |
T6067 |
cc |
and,bulb |
R3997 |
T6070 |
T6071 |
amod |
piriform,cortex |
R3998 |
T6071 |
T6067 |
conj |
cortex,bulb |
R3999 |
T6072 |
T6073 |
punct |
(,4B |
R4000 |
T6073 |
T6041 |
parataxis |
4B,showed |
R4001 |
T6074 |
T6075 |
nsubj |
n,2 |
R4002 |
T6075 |
T6073 |
ccomp |
2,4B |
R4003 |
T6076 |
T6075 |
punct |
=,2 |
R4004 |
T6077 |
T6073 |
punct |
", ",4B |
R4005 |
T6078 |
T6073 |
compound |
Figure,4B |
R4006 |
T6079 |
T6073 |
punct |
", ",4B |
R4007 |
T6080 |
T6073 |
cc |
and,4B |
R4008 |
T6081 |
T6082 |
amod |
unpublished,data |
R4009 |
T6082 |
T6073 |
conj |
data,4B |
R4010 |
T6083 |
T6073 |
punct |
),4B |
R4011 |
T6084 |
T6041 |
punct |
", ",showed |
R4012 |
T6085 |
T6041 |
cc |
but,showed |
R4013 |
T6086 |
T6087 |
nsubj |
mice,displayed |
R4014 |
T6087 |
T6041 |
conj |
displayed,showed |
R4015 |
T6088 |
T6086 |
prep |
with,mice |
R4016 |
T6089 |
T6090 |
advmod |
almost,complete |
R4017 |
T6090 |
T6091 |
amod |
complete,memory |
R4018 |
T6091 |
T6088 |
pobj |
memory,with |
R4019 |
T6092 |
T6093 |
amod |
substantial,levels |
R4020 |
T6093 |
T6087 |
dobj |
levels,displayed |
R4021 |
T6094 |
T6093 |
amod |
residual,levels |
R4022 |
T6095 |
T6096 |
compound |
GluR,B |
R4023 |
T6096 |
T6093 |
compound |
B,levels |
R4024 |
T6097 |
T6096 |
punct |
-,B |
R4025 |
T6098 |
T6087 |
prep |
in,displayed |
R4026 |
T6099 |
T6100 |
det |
all,areas |
R4027 |
T6100 |
T6098 |
pobj |
areas,in |
R4028 |
T6101 |
T6100 |
compound |
brain,areas |
R4029 |
T6102 |
T6100 |
acl |
investigated,areas |
R4030 |
T6103 |
T6104 |
punct |
(,4B |
R4031 |
T6104 |
T6087 |
parataxis |
4B,displayed |
R4032 |
T6105 |
T6106 |
nsubj |
n,2 |
R4033 |
T6106 |
T6104 |
ccomp |
2,4B |
R4034 |
T6107 |
T6106 |
punct |
=,2 |
R4035 |
T6108 |
T6104 |
punct |
", ",4B |
R4036 |
T6109 |
T6104 |
compound |
Figure,4B |
R4037 |
T6110 |
T6104 |
punct |
", ",4B |
R4038 |
T6111 |
T6104 |
cc |
and,4B |
R4039 |
T6112 |
T6113 |
amod |
unpublished,data |
R4040 |
T6113 |
T6104 |
conj |
data,4B |
R4041 |
T6114 |
T6104 |
punct |
),4B |
R4042 |
T6115 |
T6041 |
punct |
.,showed |
R4043 |
T6117 |
T6118 |
aux |
To,quantify |
R4044 |
T6118 |
T6119 |
advcl |
quantify,repeated |
R4045 |
T6120 |
T6121 |
det |
the,relation |
R4046 |
T6121 |
T6118 |
dobj |
relation,quantify |
R4047 |
T6122 |
T6121 |
prep |
between,relation |
R4048 |
T6123 |
T6124 |
amod |
residual,protein |
R4049 |
T6124 |
T6122 |
pobj |
protein,between |
R4050 |
T6125 |
T6126 |
compound |
GluR,B |
R4051 |
T6126 |
T6124 |
compound |
B,protein |
R4052 |
T6127 |
T6126 |
punct |
-,B |
R4053 |
T6128 |
T6124 |
cc |
and,protein |
R4054 |
T6129 |
T6130 |
amod |
olfactory,memory |
R4055 |
T6130 |
T6124 |
conj |
memory,protein |
R4056 |
T6131 |
T6119 |
punct |
", ",repeated |
R4057 |
T6132 |
T6133 |
det |
the,experiment |
R4058 |
T6133 |
T6119 |
nsubjpass |
experiment,repeated |
R4059 |
T6134 |
T6133 |
compound |
memory,experiment |
R4060 |
T6135 |
T6119 |
auxpass |
was,repeated |
R4061 |
T6136 |
T6119 |
prep |
with,repeated |
R4062 |
T6137 |
T6138 |
nummod |
nine,mice |
R4063 |
T6138 |
T6136 |
pobj |
mice,with |
R4064 |
T6139 |
T6138 |
amod |
additional,mice |
R4065 |
T6140 |
T6141 |
compound |
GluR,BΔFB |
R4066 |
T6141 |
T6138 |
compound |
BΔFB,mice |
R4067 |
T6142 |
T6141 |
punct |
-,BΔFB |
R4068 |
T6143 |
T6138 |
cc |
and,mice |
R4069 |
T6144 |
T6145 |
nummod |
two,animals |
R4070 |
T6145 |
T6138 |
conj |
animals,mice |
R4071 |
T6146 |
T6147 |
compound |
GluR,B2lox |
R4072 |
T6147 |
T6145 |
compound |
B2lox,animals |
R4073 |
T6148 |
T6147 |
punct |
-,B2lox |
R4074 |
T6149 |
T6145 |
compound |
control,animals |
R4075 |
T6150 |
T6151 |
punct |
(,indicated |
R4076 |
T6151 |
T6119 |
parataxis |
indicated,repeated |
R4077 |
T6152 |
T6151 |
prep |
with,indicated |
R4078 |
T6153 |
T6154 |
amod |
shaded,symbols |
R4079 |
T6154 |
T6152 |
pobj |
symbols,with |
R4080 |
T6155 |
T6151 |
prep |
in,indicated |
R4081 |
T6156 |
T6157 |
compound |
Figure,4A |
R4082 |
T6157 |
T6155 |
pobj |
4A,in |
R4083 |
T6158 |
T6151 |
punct |
),indicated |
R4084 |
T6159 |
T6119 |
punct |
", ",repeated |
R4085 |
T6160 |
T6119 |
advcl |
resulting,repeated |
R4086 |
T6161 |
T6160 |
prep |
in,resulting |
R4087 |
T6162 |
T6163 |
det |
the,mean |
R4088 |
T6163 |
T6161 |
pobj |
mean,in |
R4089 |
T6164 |
T6163 |
amod |
same,mean |
R4090 |
T6165 |
T6163 |
punct |
", ",mean |
R4091 |
T6166 |
T6163 |
conj |
variability,mean |
R4092 |
T6167 |
T6166 |
punct |
", ",variability |
R4093 |
T6168 |
T6166 |
cc |
and,variability |
R4094 |
T6169 |
T6166 |
conj |
range,variability |
R4095 |
T6170 |
T6163 |
prep |
of,mean |
R4096 |
T6171 |
T6172 |
compound |
memory,performance |
R4097 |
T6172 |
T6170 |
pobj |
performance,of |
R4098 |
T6173 |
T6174 |
punct |
(,% |
R4100 |
T6175 |
T6176 |
dep |
control,% |
R4101 |
T6176 |
T6174 |
dep |
%,% |
R4102 |
T6177 |
T6176 |
punct |
: ,% |
R4103 |
T6178 |
T6179 |
quantmod |
89,10 |
R4104 |
T6179 |
T6176 |
nummod |
10,% |
R4105 |
T6180 |
T6179 |
punct |
±,10 |
R4106 |
T6181 |
T6174 |
punct |
;,% |
R4107 |
T6182 |
T6183 |
compound |
GluR,BΔFB |
R4108 |
T6183 |
T6174 |
dep |
BΔFB,% |
R4109 |
T6184 |
T6183 |
punct |
-,BΔFB |
R4110 |
T6185 |
T6174 |
punct |
: ,% |
R4111 |
T6186 |
T6187 |
quantmod |
63,14 |
R4112 |
T6187 |
T6174 |
nummod |
14,% |
R4113 |
T6188 |
T6187 |
punct |
±,14 |
R4114 |
T6189 |
T6174 |
punct |
),% |
R4115 |
T6190 |
T6119 |
punct |
.,repeated |
R4116 |
T6192 |
T6193 |
advmod |
Subsequently,extracted |
R4117 |
T6194 |
T6193 |
punct |
", ",extracted |
R4118 |
T6195 |
T6193 |
nsubjpass |
protein,extracted |
R4119 |
T6196 |
T6193 |
auxpass |
was,extracted |
R4120 |
T6197 |
T6193 |
prep |
from,extracted |
R4121 |
T6198 |
T6199 |
amod |
olfactory,bulbs |
R4122 |
T6199 |
T6197 |
pobj |
bulbs,from |
R4123 |
T6200 |
T6199 |
punct |
", ",bulbs |
R4124 |
T6201 |
T6202 |
amod |
cortical,areas |
R4125 |
T6202 |
T6199 |
conj |
areas,bulbs |
R4126 |
T6203 |
T6202 |
punct |
", ",areas |
R4127 |
T6204 |
T6202 |
cc |
and,areas |
R4128 |
T6205 |
T6202 |
conj |
hippocampi,areas |
R4129 |
T6206 |
T6199 |
prep |
from,bulbs |
R4130 |
T6207 |
T6208 |
det |
each,mouse |
R4131 |
T6208 |
T6206 |
pobj |
mouse,from |
R4132 |
T6209 |
T6193 |
punct |
", ",extracted |
R4133 |
T6210 |
T6193 |
cc |
and,extracted |
R4134 |
T6211 |
T6212 |
compound |
GluR,B |
R4135 |
T6212 |
T6214 |
compound |
B,protein |
R4136 |
T6213 |
T6212 |
punct |
-,B |
R4137 |
T6214 |
T6215 |
nsubjpass |
protein,quantified |
R4138 |
T6215 |
T6193 |
conj |
quantified,extracted |
R4139 |
T6216 |
T6215 |
auxpass |
was,quantified |
R4140 |
T6217 |
T6218 |
punct |
(,4C |
R4141 |
T6218 |
T6215 |
parataxis |
4C,quantified |
R4142 |
T6219 |
T6218 |
compound |
Figure,4C |
R4143 |
T6220 |
T6218 |
punct |
),4C |
R4144 |
T6221 |
T6193 |
punct |
.,extracted |
R4145 |
T6223 |
T6224 |
det |
The,correlations |
R4146 |
T6224 |
T6226 |
nsubjpass |
correlations,depicted |
R4147 |
T6225 |
T6224 |
amod |
summarized,correlations |
R4148 |
T6227 |
T6226 |
auxpass |
are,depicted |
R4149 |
T6228 |
T6226 |
prep |
in,depicted |
R4150 |
T6229 |
T6230 |
compound |
Figure,4D |
R4151 |
T6230 |
T6228 |
pobj |
4D,in |
R4152 |
T6231 |
T6232 |
punct |
(,used |
R4153 |
T6232 |
T6226 |
parataxis |
used,depicted |
R4154 |
T6233 |
T6234 |
nummod |
two,animals |
R4155 |
T6234 |
T6232 |
nsubjpass |
animals,used |
R4156 |
T6235 |
T6232 |
auxpass |
were,used |
R4157 |
T6236 |
T6232 |
prep |
for,used |
R4158 |
T6237 |
T6238 |
amod |
immunofluorescent,analysis |
R4159 |
T6238 |
T6236 |
pobj |
analysis,for |
R4160 |
T6239 |
T6240 |
dep |
that,yielded |
R4161 |
T6240 |
T6238 |
relcl |
yielded,analysis |
R4162 |
T6241 |
T6242 |
det |
the,results |
R4163 |
T6242 |
T6240 |
dobj |
results,yielded |
R4164 |
T6243 |
T6242 |
amod |
same,results |
R4165 |
T6244 |
T6240 |
prep |
as,yielded |
R4166 |
T6245 |
T6244 |
prep |
in,as |
R4167 |
T6246 |
T6247 |
det |
the,experiment |
R4168 |
T6247 |
T6245 |
pobj |
experiment,in |
R4169 |
T6248 |
T6247 |
amod |
first,experiment |
R4170 |
T6249 |
T6232 |
punct |
),used |
R4171 |
T6250 |
T6226 |
punct |
.,depicted |
R4172 |
T6252 |
T6253 |
mark |
Whereas,correlated |
R4173 |
T6253 |
T6261 |
advcl |
correlated,observed |
R4174 |
T6254 |
T6255 |
det |
no,parameter |
R4175 |
T6255 |
T6253 |
nsubj |
parameter,correlated |
R4176 |
T6256 |
T6257 |
npadvmod |
learning,related |
R4177 |
T6257 |
T6255 |
amod |
related,parameter |
R4178 |
T6258 |
T6256 |
cc |
or,learning |
R4179 |
T6259 |
T6256 |
conj |
discrimination,learning |
R4180 |
T6260 |
T6257 |
punct |
-,related |
R4181 |
T6262 |
T6253 |
prep |
with,correlated |
R4182 |
T6263 |
T6264 |
amod |
residual,levels |
R4183 |
T6264 |
T6262 |
pobj |
levels,with |
R4184 |
T6265 |
T6264 |
compound |
protein,levels |
R4185 |
T6266 |
T6267 |
punct |
(,4D |
R4186 |
T6267 |
T6253 |
parataxis |
4D,correlated |
R4187 |
T6268 |
T6267 |
compound |
Figure,4D |
R4188 |
T6269 |
T6267 |
punct |
", ",4D |
R4189 |
T6270 |
T6271 |
nsubj |
R2,0.3 |
R4190 |
T6271 |
T6267 |
ccomp |
0.3,4D |
R4191 |
T6272 |
T6271 |
punct |
<,0.3 |
R4192 |
T6273 |
T6267 |
punct |
),4D |
R4193 |
T6274 |
T6261 |
punct |
", ",observed |
R4194 |
T6275 |
T6276 |
det |
a,correlation |
R4195 |
T6276 |
T6261 |
nsubjpass |
correlation,observed |
R4196 |
T6277 |
T6276 |
amod |
strong,correlation |
R4197 |
T6278 |
T6276 |
prep |
between,correlation |
R4198 |
T6279 |
T6278 |
pobj |
memory,between |
R4199 |
T6280 |
T6279 |
cc |
and,memory |
R4200 |
T6281 |
T6282 |
compound |
GluR,B |
R4201 |
T6282 |
T6284 |
compound |
B,protein |
R4202 |
T6283 |
T6282 |
punct |
-,B |
R4203 |
T6284 |
T6279 |
conj |
protein,memory |
R4204 |
T6285 |
T6261 |
auxpass |
was,observed |
R4205 |
T6286 |
T6261 |
prep |
in,observed |
R4206 |
T6287 |
T6286 |
pobj |
hippocampus,in |
R4207 |
T6288 |
T6289 |
punct |
(,4D |
R4208 |
T6289 |
T6287 |
parataxis |
4D,hippocampus |
R4209 |
T6290 |
T6289 |
compound |
Figure,4D |
R4210 |
T6291 |
T6289 |
punct |
", ",4D |
R4211 |
T6292 |
T6293 |
nsubj |
R2,0.72 |
R4212 |
T6293 |
T6289 |
ccomp |
0.72,4D |
R4213 |
T6294 |
T6293 |
punct |
=,0.72 |
R4214 |
T6295 |
T6289 |
punct |
", ",4D |
R4215 |
T6296 |
T6297 |
nsubj |
p,0.003 |
R4216 |
T6297 |
T6289 |
ccomp |
0.003,4D |
R4217 |
T6298 |
T6297 |
punct |
<,0.003 |
R4218 |
T6299 |
T6289 |
punct |
", ",4D |
R4219 |
T6300 |
T6301 |
nsubj |
n,10 |
R4220 |
T6301 |
T6289 |
ccomp |
10,4D |
R4221 |
T6302 |
T6301 |
punct |
=,10 |
R4222 |
T6303 |
T6289 |
punct |
),4D |
R4223 |
T6304 |
T6287 |
cc |
and,hippocampus |
R4224 |
T6305 |
T6306 |
amod |
cortical,areas |
R4225 |
T6306 |
T6287 |
conj |
areas,hippocampus |
R4226 |
T6307 |
T6308 |
punct |
(,4D |
R4227 |
T6308 |
T6306 |
parataxis |
4D,areas |
R4228 |
T6309 |
T6308 |
compound |
Figure,4D |
R4229 |
T6310 |
T6308 |
punct |
", ",4D |
R4230 |
T6311 |
T6312 |
nsubj |
R2,0.62 |
R4231 |
T6312 |
T6308 |
ccomp |
0.62,4D |
R4232 |
T6313 |
T6312 |
punct |
=,0.62 |
R4233 |
T6314 |
T6308 |
punct |
", ",4D |
R4234 |
T6315 |
T6316 |
nsubj |
p,0.006 |
R4235 |
T6316 |
T6308 |
ccomp |
0.006,4D |
R4236 |
T6317 |
T6316 |
punct |
<,0.006 |
R4237 |
T6318 |
T6308 |
punct |
", ",4D |
R4238 |
T6319 |
T6320 |
nsubj |
n,10 |
R4239 |
T6320 |
T6308 |
ccomp |
10,4D |
R4240 |
T6321 |
T6320 |
punct |
=,10 |
R4241 |
T6322 |
T6308 |
punct |
),4D |
R4242 |
T6323 |
T6261 |
punct |
.,observed |
R4243 |
T6325 |
T6326 |
advmod |
Only,correlation |
R4244 |
T6326 |
T6330 |
nsubjpass |
correlation,found |
R4245 |
T6327 |
T6326 |
det |
a,correlation |
R4246 |
T6328 |
T6329 |
advmod |
weakly,significant |
R4247 |
T6329 |
T6326 |
amod |
significant,correlation |
R4248 |
T6331 |
T6330 |
auxpass |
was,found |
R4249 |
T6332 |
T6330 |
prep |
in,found |
R4250 |
T6333 |
T6334 |
det |
the,bulb |
R4251 |
T6334 |
T6332 |
pobj |
bulb,in |
R4252 |
T6335 |
T6334 |
amod |
olfactory,bulb |
R4253 |
T6336 |
T6337 |
punct |
(,4D |
R4254 |
T6337 |
T6330 |
parataxis |
4D,found |
R4255 |
T6338 |
T6337 |
compound |
Figure,4D |
R4256 |
T6339 |
T6337 |
punct |
", ",4D |
R4257 |
T6340 |
T6341 |
nsubj |
R2,0.48 |
R4258 |
T6341 |
T6337 |
ccomp |
0.48,4D |
R4259 |
T6342 |
T6341 |
punct |
=,0.48 |
R4260 |
T6343 |
T6337 |
punct |
", ",4D |
R4261 |
T6344 |
T6345 |
nsubj |
p,0.03 |
R4262 |
T6345 |
T6337 |
ccomp |
0.03,4D |
R4263 |
T6346 |
T6345 |
punct |
=,0.03 |
R4264 |
T6347 |
T6337 |
punct |
", ",4D |
R4265 |
T6348 |
T6349 |
nsubj |
n,10 |
R4266 |
T6349 |
T6337 |
ccomp |
10,4D |
R4267 |
T6350 |
T6349 |
punct |
=,10 |
R4268 |
T6351 |
T6337 |
punct |
),4D |
R4269 |
T6352 |
T6330 |
punct |
.,found |
R4270 |
T6354 |
T6355 |
compound |
GluR,A |
R4271 |
T6355 |
T6357 |
compound |
A,levels |
R4272 |
T6356 |
T6355 |
punct |
-,A |
R4273 |
T6357 |
T6358 |
nsubj |
levels,were |
R4274 |
T6359 |
T6358 |
acomp |
unchanged,were |
R4275 |
T6360 |
T6358 |
prep |
from,were |
R4276 |
T6361 |
T6362 |
amod |
wild,type |
R4277 |
T6362 |
T6360 |
pobj |
type,from |
R4278 |
T6363 |
T6362 |
punct |
-,type |
R4279 |
T6364 |
T6358 |
punct |
", ",were |
R4280 |
T6365 |
T6358 |
advcl |
indicating,were |
R4281 |
T6366 |
T6367 |
mark |
that,is |
R4282 |
T6367 |
T6365 |
ccomp |
is,indicating |
R4283 |
T6368 |
T6369 |
amod |
compensatory,regulation |
R4284 |
T6369 |
T6367 |
nsubj |
regulation,is |
R4285 |
T6370 |
T6369 |
amod |
up,regulation |
R4286 |
T6371 |
T6369 |
punct |
-,regulation |
R4287 |
T6372 |
T6369 |
prep |
of,regulation |
R4288 |
T6373 |
T6374 |
amod |
other,subunits |
R4289 |
T6374 |
T6372 |
pobj |
subunits,of |
R4290 |
T6375 |
T6374 |
compound |
AMPAR,subunits |
R4291 |
T6376 |
T6367 |
acomp |
unlikely,is |
R4292 |
T6377 |
T6378 |
punct |
(,levels |
R4293 |
T6378 |
T6358 |
parataxis |
levels,were |
R4294 |
T6379 |
T6380 |
compound |
GluR,A |
R4295 |
T6380 |
T6378 |
compound |
A,levels |
R4296 |
T6381 |
T6380 |
punct |
-,A |
R4297 |
T6382 |
T6378 |
amod |
relative,levels |
R4298 |
T6383 |
T6382 |
prep |
to,relative |
R4299 |
T6384 |
T6383 |
pobj |
control,to |
R4300 |
T6385 |
T6378 |
punct |
: ,levels |
R4301 |
T6386 |
T6387 |
nummod |
1.02,0.05 |
R4302 |
T6387 |
T6389 |
dep |
0.05,10 |
R4303 |
T6388 |
T6387 |
punct |
±,0.05 |
R4304 |
T6389 |
T6378 |
dep |
10,levels |
R4305 |
T6390 |
T6389 |
punct |
", ",10 |
R4306 |
T6391 |
T6392 |
nmod |
mean,SEM |
R4307 |
T6392 |
T6389 |
dep |
SEM,10 |
R4308 |
T6393 |
T6392 |
punct |
±,SEM |
R4309 |
T6394 |
T6389 |
punct |
", ",10 |
R4310 |
T6395 |
T6389 |
nsubj |
n,10 |
R4311 |
T6396 |
T6389 |
punct |
=,10 |
R4312 |
T6397 |
T6378 |
punct |
),levels |
R4313 |
T6398 |
T6358 |
punct |
.,were |
R4314 |
T6400 |
T6401 |
prep |
In,showed |
R4315 |
T6402 |
T6400 |
pobj |
summary,In |
R4316 |
T6403 |
T6401 |
punct |
", ",showed |
R4317 |
T6404 |
T6401 |
nsubj |
mice,showed |
R4318 |
T6405 |
T6404 |
prep |
with,mice |
R4319 |
T6406 |
T6407 |
amod |
reduced,levels |
R4320 |
T6407 |
T6405 |
pobj |
levels,with |
R4321 |
T6408 |
T6409 |
compound |
GluR,B |
R4322 |
T6409 |
T6407 |
compound |
B,levels |
R4323 |
T6410 |
T6409 |
punct |
-,B |
R4324 |
T6411 |
T6407 |
prep |
in,levels |
R4325 |
T6412 |
T6413 |
compound |
forebrain,areas |
R4326 |
T6413 |
T6411 |
pobj |
areas,in |
R4327 |
T6414 |
T6415 |
amod |
decreased,memory |
R4328 |
T6415 |
T6401 |
dobj |
memory,showed |
R4329 |
T6416 |
T6415 |
amod |
olfactory,memory |
R4330 |
T6417 |
T6415 |
punct |
", ",memory |
R4331 |
T6418 |
T6419 |
dep |
which,correlated |
R4332 |
T6419 |
T6415 |
relcl |
correlated,memory |
R4333 |
T6420 |
T6419 |
advmod |
tightly,correlated |
R4334 |
T6421 |
T6419 |
prep |
with,correlated |
R4335 |
T6422 |
T6423 |
det |
a,reduction |
R4336 |
T6423 |
T6421 |
pobj |
reduction,with |
R4337 |
T6424 |
T6423 |
prep |
in,reduction |
R4338 |
T6425 |
T6426 |
compound |
GluR,B |
R4339 |
T6426 |
T6428 |
compound |
B,levels |
R4340 |
T6427 |
T6426 |
punct |
-,B |
R4341 |
T6428 |
T6424 |
pobj |
levels,in |
R4342 |
T6429 |
T6423 |
prep |
in,reduction |
R4343 |
T6430 |
T6431 |
det |
the,hippocampus |
R4344 |
T6431 |
T6429 |
pobj |
hippocampus,in |
R4345 |
T6432 |
T6431 |
cc |
and,hippocampus |
R4346 |
T6433 |
T6434 |
amod |
cortical,areas |
R4347 |
T6434 |
T6431 |
conj |
areas,hippocampus |
R4348 |
T6435 |
T6401 |
punct |
.,showed |
R4349 |
T6437 |
T6438 |
amod |
Enhanced,learning |
R4350 |
T6438 |
T6440 |
nsubj |
learning,was |
R4351 |
T6439 |
T6438 |
compound |
odor,learning |
R4352 |
T6441 |
T6438 |
cc |
and,learning |
R4353 |
T6442 |
T6438 |
conj |
discrimination,learning |
R4354 |
T6443 |
T6440 |
punct |
", ",was |
R4355 |
T6444 |
T6440 |
prep |
on,was |
R4356 |
T6445 |
T6446 |
det |
the,hand |
R4357 |
T6446 |
T6444 |
pobj |
hand,on |
R4358 |
T6447 |
T6446 |
amod |
other,hand |
R4359 |
T6448 |
T6440 |
punct |
", ",was |
R4360 |
T6449 |
T6440 |
acomp |
independent,was |
R4361 |
T6450 |
T6449 |
prep |
of,independent |
R4362 |
T6451 |
T6452 |
amod |
residual,levels |
R4363 |
T6452 |
T6450 |
pobj |
levels,of |
R4364 |
T6453 |
T6454 |
compound |
GluR,B |
R4365 |
T6454 |
T6452 |
compound |
B,levels |
R4366 |
T6455 |
T6454 |
punct |
-,B |
R4367 |
T6456 |
T6440 |
prep |
in,was |
R4368 |
T6457 |
T6458 |
det |
the,bulb |
R4369 |
T6458 |
T6456 |
pobj |
bulb,in |
R4370 |
T6459 |
T6458 |
amod |
olfactory,bulb |
R4371 |
T6460 |
T6458 |
cc |
and,bulb |
R4372 |
T6461 |
T6462 |
amod |
other,areas |
R4373 |
T6462 |
T6458 |
conj |
areas,bulb |
R4374 |
T6463 |
T6462 |
compound |
forebrain,areas |
R4375 |
T6464 |
T6440 |
punct |
", ",was |
R4376 |
T6465 |
T6440 |
advcl |
indicating,was |
R4377 |
T6466 |
T6467 |
mark |
that,are |
R4378 |
T6467 |
T6465 |
ccomp |
are,indicating |
R4379 |
T6468 |
T6469 |
amod |
moderate,reductions |
R4380 |
T6469 |
T6467 |
nsubj |
reductions,are |
R4381 |
T6470 |
T6471 |
compound |
GluR,B |
R4382 |
T6471 |
T6469 |
compound |
B,reductions |
R4383 |
T6472 |
T6471 |
punct |
-,B |
R4384 |
T6473 |
T6467 |
acomp |
sufficient,are |
R4385 |
T6474 |
T6475 |
aux |
to,saturate |
R4386 |
T6475 |
T6473 |
xcomp |
saturate,sufficient |
R4387 |
T6476 |
T6477 |
amod |
enhanced,learning |
R4388 |
T6477 |
T6475 |
dobj |
learning,saturate |
R4389 |
T6478 |
T6477 |
compound |
odor,learning |
R4390 |
T6479 |
T6477 |
cc |
and,learning |
R4391 |
T6480 |
T6477 |
conj |
discrimination,learning |
R4392 |
T6481 |
T6440 |
punct |
.,was |
R4393 |
T6483 |
T6484 |
advmod |
Thus,be |
R4394 |
T6485 |
T6484 |
punct |
", ",be |
R4395 |
T6486 |
T6487 |
mark |
although,mediated |
R4396 |
T6487 |
T6484 |
advcl |
mediated,be |
R4397 |
T6488 |
T6487 |
nsubjpass |
both,mediated |
R4398 |
T6489 |
T6487 |
auxpass |
are,mediated |
R4399 |
T6490 |
T6487 |
agent |
by,mediated |
R4400 |
T6491 |
T6490 |
pobj |
alterations,by |
R4401 |
T6492 |
T6491 |
prep |
in,alterations |
R4402 |
T6493 |
T6494 |
det |
the,subunit |
R4403 |
T6494 |
T6492 |
pobj |
subunit,in |
R4404 |
T6495 |
T6494 |
compound |
AMPAR,subunit |
R4405 |
T6496 |
T6497 |
compound |
GluR,B |
R4406 |
T6497 |
T6494 |
appos |
B,subunit |
R4407 |
T6498 |
T6497 |
punct |
-,B |
R4408 |
T6499 |
T6487 |
punct |
", ",mediated |
R4409 |
T6500 |
T6487 |
prep |
due,mediated |
R4410 |
T6501 |
T6500 |
pcomp |
to,due |
R4411 |
T6502 |
T6503 |
det |
the,curves |
R4412 |
T6503 |
T6500 |
pobj |
curves,due |
R4413 |
T6504 |
T6505 |
advmod |
qualitatively,different |
R4414 |
T6505 |
T6503 |
amod |
different,curves |
R4415 |
T6506 |
T6507 |
compound |
dose,response |
R4416 |
T6507 |
T6503 |
compound |
response,curves |
R4417 |
T6508 |
T6507 |
punct |
-,response |
R4418 |
T6509 |
T6484 |
punct |
", ",be |
R4419 |
T6510 |
T6511 |
det |
the,phenotypes |
R4420 |
T6511 |
T6484 |
nsubj |
phenotypes,be |
R4421 |
T6512 |
T6511 |
prep |
regarding,phenotypes |
R4422 |
T6513 |
T6514 |
amod |
olfactory,memory |
R4423 |
T6514 |
T6512 |
pobj |
memory,regarding |
R4424 |
T6515 |
T6514 |
punct |
", ",memory |
R4425 |
T6516 |
T6514 |
cc |
and,memory |
R4426 |
T6517 |
T6518 |
amod |
olfactory,discrimination |
R4427 |
T6518 |
T6514 |
conj |
discrimination,memory |
R4428 |
T6519 |
T6518 |
compound |
learning,discrimination |
R4429 |
T6520 |
T6518 |
punct |
/,discrimination |
R4430 |
T6521 |
T6484 |
aux |
must,be |
R4431 |
T6522 |
T6523 |
advmod |
mechanistically,distinct |
R4432 |
T6523 |
T6484 |
acomp |
distinct,be |
R4433 |
T6524 |
T6484 |
punct |
.,be |
R4434 |
T6879 |
T6880 |
amod |
Partial,Rescue |
R4435 |
T6881 |
T6880 |
prep |
of,Rescue |
R4436 |
T6882 |
T6883 |
amod |
Olfactory,Deficit |
R4437 |
T6883 |
T6881 |
pobj |
Deficit,of |
R4438 |
T6884 |
T6883 |
compound |
Memory,Deficit |
R4439 |
T6885 |
T6880 |
prep |
by,Rescue |
R4440 |
T6886 |
T6887 |
amod |
Selective,Expression |
R4441 |
T6887 |
T6885 |
pobj |
Expression,by |
R4442 |
T6888 |
T6887 |
amod |
Transgenic,Expression |
R4443 |
T6889 |
T6890 |
compound |
GluR,B |
R4444 |
T6890 |
T6887 |
compound |
B,Expression |
R4445 |
T6891 |
T6890 |
punct |
-,B |
R4446 |
T6892 |
T6880 |
prep |
in,Rescue |
R4447 |
T6893 |
T6892 |
pobj |
Hippocampus,in |
R4448 |
T6894 |
T6893 |
cc |
and,Hippocampus |
R4449 |
T6895 |
T6896 |
amod |
Piriform,Cortex |
R4450 |
T6896 |
T6893 |
conj |
Cortex,Hippocampus |
R4451 |
T6897 |
T6880 |
prep |
in,Rescue |
R4452 |
T6898 |
T6899 |
compound |
GluR,BΔFB |
R4453 |
T6899 |
T6901 |
compound |
BΔFB,Mice |
R4454 |
T6900 |
T6899 |
punct |
-,BΔFB |
R4455 |
T6901 |
T6897 |
pobj |
Mice,in |
R4456 |
T6903 |
T6904 |
det |
The,effect |
R4457 |
T6904 |
T6905 |
nsubj |
effect,indicated |
R4458 |
T6906 |
T6904 |
prep |
of,effect |
R4459 |
T6907 |
T6908 |
amod |
selective,depletion |
R4460 |
T6908 |
T6906 |
pobj |
depletion,of |
R4461 |
T6909 |
T6910 |
compound |
GluR,B |
R4462 |
T6910 |
T6908 |
compound |
B,depletion |
R4463 |
T6911 |
T6910 |
punct |
-,B |
R4464 |
T6912 |
T6908 |
prep |
in,depletion |
R4465 |
T6913 |
T6912 |
pobj |
mice,in |
R4466 |
T6914 |
T6915 |
mark |
that,are |
R4467 |
T6915 |
T6905 |
ccomp |
are,indicated |
R4468 |
T6916 |
T6917 |
compound |
GluR,B |
R4469 |
T6917 |
T6919 |
npadvmod |
B,containing |
R4470 |
T6918 |
T6917 |
punct |
-,B |
R4471 |
T6919 |
T6921 |
amod |
containing,AMPARs |
R4472 |
T6920 |
T6919 |
punct |
-,containing |
R4473 |
T6921 |
T6915 |
nsubj |
AMPARs,are |
R4474 |
T6922 |
T6921 |
prep |
in,AMPARs |
R4475 |
T6923 |
T6924 |
det |
the,hippocampus |
R4476 |
T6924 |
T6922 |
pobj |
hippocampus,in |
R4477 |
T6925 |
T6924 |
punct |
", ",hippocampus |
R4478 |
T6926 |
T6924 |
cc |
and,hippocampus |
R4479 |
T6927 |
T6926 |
punct |
/,and |
R4480 |
T6928 |
T6926 |
cc |
or,and |
R4481 |
T6929 |
T6930 |
punct |
(,cortex |
R4482 |
T6930 |
T6924 |
conj |
cortex,hippocampus |
R4483 |
T6931 |
T6930 |
amod |
olfactory,cortex |
R4484 |
T6932 |
T6930 |
punct |
),cortex |
R4485 |
T6933 |
T6915 |
acomp |
likely,are |
R4486 |
T6934 |
T6935 |
aux |
to,be |
R4487 |
T6935 |
T6933 |
xcomp |
be,likely |
R4488 |
T6936 |
T6935 |
acomp |
important,be |
R4489 |
T6937 |
T6936 |
prep |
for,important |
R4490 |
T6938 |
T6939 |
amod |
olfactory,memory |
R4491 |
T6939 |
T6937 |
pobj |
memory,for |
R4492 |
T6940 |
T6905 |
punct |
.,indicated |
R4493 |
T6942 |
T6943 |
det |
The,phenotype |
R4494 |
T6943 |
T6946 |
nsubj |
phenotype,be |
R4495 |
T6944 |
T6945 |
amod |
olfactory,memory |
R4496 |
T6945 |
T6943 |
compound |
memory,phenotype |
R4497 |
T6946 |
T6948 |
ccomp |
be,evoked |
R4498 |
T6947 |
T6946 |
aux |
could,be |
R4499 |
T6949 |
T6946 |
prep |
due,be |
R4500 |
T6950 |
T6949 |
pcomp |
to,due |
R4501 |
T6951 |
T6949 |
pobj |
depletion,due |
R4502 |
T6952 |
T6951 |
prep |
of,depletion |
R4503 |
T6953 |
T6954 |
compound |
GluR,B |
R4504 |
T6954 |
T6952 |
pobj |
B,of |
R4505 |
T6955 |
T6954 |
punct |
-,B |
R4506 |
T6956 |
T6951 |
prep |
in,depletion |
R4507 |
T6957 |
T6958 |
amod |
olfactory,cortex |
R4508 |
T6958 |
T6956 |
pobj |
cortex,in |
R4509 |
T6959 |
T6958 |
cc |
or,cortex |
R4510 |
T6960 |
T6958 |
conj |
hippocampus,cortex |
R4511 |
T6961 |
T6948 |
punct |
;,evoked |
R4512 |
T6962 |
T6963 |
amod |
enhanced,capabilities |
R4513 |
T6963 |
T6948 |
nsubjpass |
capabilities,evoked |
R4514 |
T6964 |
T6963 |
nmod |
learning,capabilities |
R4515 |
T6965 |
T6964 |
cc |
and,learning |
R4516 |
T6966 |
T6964 |
conj |
discrimination,learning |
R4517 |
T6967 |
T6948 |
aux |
might,evoked |
R4518 |
T6968 |
T6948 |
advmod |
rather,evoked |
R4519 |
T6969 |
T6948 |
auxpass |
be,evoked |
R4520 |
T6970 |
T6948 |
agent |
by,evoked |
R4521 |
T6971 |
T6970 |
pobj |
AMPARs,by |
R4522 |
T6972 |
T6971 |
acl |
lacking,AMPARs |
R4523 |
T6973 |
T6974 |
compound |
GluR,B |
R4524 |
T6974 |
T6972 |
dobj |
B,lacking |
R4525 |
T6975 |
T6974 |
punct |
-,B |
R4526 |
T6976 |
T6972 |
prep |
in,lacking |
R4527 |
T6977 |
T6978 |
det |
the,bulb |
R4528 |
T6978 |
T6976 |
pobj |
bulb,in |
R4529 |
T6979 |
T6978 |
amod |
olfactory,bulb |
R4530 |
T6980 |
T6948 |
punct |
.,evoked |
R4531 |
T6982 |
T6983 |
aux |
To,obtain |
R4532 |
T6983 |
T6984 |
advcl |
obtain,expressed |
R4533 |
T6985 |
T6986 |
amod |
independent,evidence |
R4534 |
T6986 |
T6983 |
dobj |
evidence,obtain |
R4535 |
T6987 |
T6986 |
prep |
for,evidence |
R4536 |
T6988 |
T6989 |
det |
this,dissection |
R4537 |
T6989 |
T6987 |
pobj |
dissection,for |
R4538 |
T6990 |
T6989 |
amod |
spatial,dissection |
R4539 |
T6991 |
T6990 |
cc |
and,spatial |
R4540 |
T6992 |
T6990 |
conj |
mechanistic,spatial |
R4541 |
T6993 |
T6989 |
prep |
of,dissection |
R4542 |
T6994 |
T6995 |
det |
the,roles |
R4543 |
T6995 |
T6993 |
pobj |
roles,of |
R4544 |
T6996 |
T6995 |
prep |
of,roles |
R4545 |
T6997 |
T6998 |
npadvmod |
Ca2,permeable |
R4546 |
T6998 |
T7001 |
amod |
permeable,AMPARs |
R4547 |
T6999 |
T6997 |
punct |
+,Ca2 |
R4548 |
T7000 |
T6998 |
punct |
-,permeable |
R4549 |
T7001 |
T6996 |
pobj |
AMPARs,of |
R4550 |
T7002 |
T6984 |
punct |
", ",expressed |
R4551 |
T7003 |
T6984 |
nsubj |
we,expressed |
R4552 |
T7004 |
T6984 |
prep |
by,expressed |
R4553 |
T7005 |
T7006 |
amod |
transgenic,means |
R4554 |
T7006 |
T7004 |
pobj |
means,by |
R4555 |
T7007 |
T7008 |
npadvmod |
N,terminally |
R4556 |
T7008 |
T6984 |
advmod |
terminally,expressed |
R4557 |
T7009 |
T7008 |
punct |
-,terminally |
R4558 |
T7010 |
T7011 |
amod |
green,protein |
R4559 |
T7011 |
T7013 |
npadvmod |
protein,tagged |
R4560 |
T7012 |
T7011 |
amod |
fluorescent,protein |
R4561 |
T7013 |
T7018 |
amod |
tagged,B |
R4562 |
T7014 |
T7011 |
punct |
(,protein |
R4563 |
T7015 |
T7011 |
appos |
GFP,protein |
R4564 |
T7016 |
T7013 |
punct |
),tagged |
R4565 |
T7017 |
T7013 |
punct |
-,tagged |
R4566 |
T7018 |
T6984 |
dobj |
B,expressed |
R4567 |
T7019 |
T7018 |
compound |
GluR,B |
R4568 |
T7020 |
T7018 |
punct |
-,B |
R4569 |
T7021 |
T7022 |
advmod |
specifically,in |
R4570 |
T7022 |
T6984 |
prep |
in,expressed |
R4571 |
T7023 |
T7022 |
pobj |
hippocampus,in |
R4572 |
T7024 |
T7023 |
cc |
and,hippocampus |
R4573 |
T7025 |
T7026 |
amod |
piriform,cortex |
R4574 |
T7026 |
T7023 |
conj |
cortex,hippocampus |
R4575 |
T7027 |
T7023 |
prep |
of,hippocampus |
R4576 |
T7028 |
T7029 |
compound |
GluR,BΔFB |
R4577 |
T7029 |
T7031 |
compound |
BΔFB,mice |
R4578 |
T7030 |
T7029 |
punct |
-,BΔFB |
R4579 |
T7031 |
T7027 |
pobj |
mice,of |
R4580 |
T7032 |
T7033 |
punct |
(,5A |
R4581 |
T7033 |
T6984 |
parataxis |
5A,expressed |
R4582 |
T7034 |
T7033 |
compound |
Figure,5A |
R4583 |
T7035 |
T7033 |
cc |
and,5A |
R4584 |
T7036 |
T7033 |
conj |
5B,5A |
R4585 |
T7037 |
T7033 |
punct |
),5A |
R4586 |
T7038 |
T6984 |
punct |
.,expressed |
R4587 |
T7040 |
T7041 |
prep |
In,expected |
R4588 |
T7042 |
T7040 |
pobj |
accordance,In |
R4589 |
T7043 |
T7042 |
prep |
with,accordance |
R4590 |
T7044 |
T7045 |
det |
the,dependence |
R4591 |
T7045 |
T7043 |
pobj |
dependence,with |
R4592 |
T7046 |
T7045 |
amod |
proposed,dependence |
R4593 |
T7047 |
T7045 |
compound |
region,dependence |
R4594 |
T7048 |
T7045 |
punct |
-,dependence |
R4595 |
T7049 |
T7041 |
punct |
", ",expected |
R4596 |
T7050 |
T7041 |
nsubj |
we,expected |
R4597 |
T7051 |
T7052 |
mark |
that,improve |
R4598 |
T7052 |
T7041 |
ccomp |
improve,expected |
R4599 |
T7053 |
T7054 |
amod |
additional,subunits |
R4600 |
T7054 |
T7052 |
nsubj |
subunits,improve |
R4601 |
T7055 |
T7056 |
compound |
GluR,B |
R4602 |
T7056 |
T7054 |
compound |
B,subunits |
R4603 |
T7057 |
T7056 |
punct |
-,B |
R4604 |
T7058 |
T7054 |
prep |
in,subunits |
R4605 |
T7059 |
T7058 |
pobj |
hippocampus,in |
R4606 |
T7060 |
T7059 |
cc |
and,hippocampus |
R4607 |
T7061 |
T7060 |
punct |
/,and |
R4608 |
T7062 |
T7060 |
cc |
or,and |
R4609 |
T7063 |
T7064 |
amod |
piriform,cortex |
R4610 |
T7064 |
T7059 |
conj |
cortex,hippocampus |
R4611 |
T7065 |
T7066 |
compound |
odor,memory |
R4612 |
T7066 |
T7052 |
dobj |
memory,improve |
R4613 |
T7067 |
T7052 |
cc |
but,improve |
R4614 |
T7068 |
T7069 |
aux |
do,alter |
R4615 |
T7069 |
T7052 |
conj |
alter,improve |
R4616 |
T7070 |
T7069 |
neg |
not,alter |
R4617 |
T7071 |
T7072 |
compound |
odor,discrimination |
R4618 |
T7072 |
T7073 |
compound |
discrimination,performance |
R4619 |
T7073 |
T7069 |
dobj |
performance,alter |
R4620 |
T7074 |
T7041 |
punct |
.,expected |
R4621 |
T7076 |
T7077 |
det |
The,line |
R4622 |
T7077 |
T7079 |
nsubj |
line,had |
R4623 |
T7078 |
T7077 |
compound |
mouse,line |
R4624 |
T7080 |
T7077 |
acl |
employed,line |
R4625 |
T7081 |
T7080 |
prep |
for,employed |
R4626 |
T7082 |
T7083 |
det |
this,purpose |
R4627 |
T7083 |
T7081 |
pobj |
purpose,for |
R4628 |
T7084 |
T7077 |
punct |
", ",line |
R4629 |
T7085 |
T7077 |
acl |
termed,line |
R4630 |
T7086 |
T7087 |
compound |
GluR,BRescue |
R4631 |
T7087 |
T7085 |
oprd |
BRescue,termed |
R4632 |
T7088 |
T7087 |
punct |
-,BRescue |
R4633 |
T7089 |
T7079 |
punct |
", ",had |
R4634 |
T7090 |
T7091 |
det |
the,background |
R4635 |
T7091 |
T7079 |
dobj |
background,had |
R4636 |
T7092 |
T7091 |
amod |
genetic,background |
R4637 |
T7093 |
T7091 |
prep |
of,background |
R4638 |
T7094 |
T7095 |
compound |
GluR,BΔFB |
R4639 |
T7095 |
T7097 |
compound |
BΔFB,mice |
R4640 |
T7096 |
T7095 |
punct |
-,BΔFB |
R4641 |
T7097 |
T7093 |
pobj |
mice,of |
R4642 |
T7098 |
T7079 |
cc |
but,had |
R4643 |
T7099 |
T7100 |
advmod |
additionally,carried |
R4644 |
T7100 |
T7079 |
conj |
carried,had |
R4645 |
T7101 |
T7102 |
det |
a,module |
R4646 |
T7102 |
T7100 |
dobj |
module,carried |
R4647 |
T7103 |
T7102 |
amod |
bidirectional,module |
R4648 |
T7104 |
T7102 |
prep |
for,module |
R4649 |
T7105 |
T7106 |
nmod |
β,galactosidase |
R4650 |
T7106 |
T7108 |
nmod |
galactosidase,expression |
R4651 |
T7107 |
T7106 |
punct |
-,galactosidase |
R4652 |
T7108 |
T7104 |
pobj |
expression,for |
R4653 |
T7109 |
T7106 |
cc |
and,galactosidase |
R4654 |
T7110 |
T7111 |
compound |
GFPGluR,B |
R4655 |
T7111 |
T7106 |
conj |
B,galactosidase |
R4656 |
T7112 |
T7111 |
punct |
-,B |
R4657 |
T7113 |
T7102 |
punct |
", ",module |
R4658 |
T7114 |
T7102 |
amod |
responsive,module |
R4659 |
T7115 |
T7114 |
prep |
to,responsive |
R4660 |
T7116 |
T7117 |
det |
the,transactivator |
R4661 |
T7117 |
T7115 |
pobj |
transactivator,to |
R4662 |
T7118 |
T7119 |
npadvmod |
tetracycline,controlled |
R4663 |
T7119 |
T7117 |
amod |
controlled,transactivator |
R4664 |
T7120 |
T7119 |
punct |
-,controlled |
R4665 |
T7121 |
T7117 |
amod |
transcriptional,transactivator |
R4666 |
T7122 |
T7123 |
punct |
[,62 |
R4667 |
T7123 |
T7100 |
parataxis |
62,carried |
R4668 |
T7124 |
T7123 |
punct |
],62 |
R4669 |
T7125 |
T7079 |
punct |
.,had |
R4670 |
T7127 |
T7128 |
det |
The,transactivator |
R4671 |
T7128 |
T7129 |
nsubj |
transactivator,was |
R4672 |
T7130 |
T7129 |
prep |
under,was |
R4673 |
T7131 |
T7132 |
det |
the,control |
R4674 |
T7132 |
T7130 |
pobj |
control,under |
R4675 |
T7133 |
T7132 |
prep |
of,control |
R4676 |
T7134 |
T7135 |
det |
a,fragment |
R4677 |
T7135 |
T7133 |
pobj |
fragment,of |
R4678 |
T7136 |
T7135 |
amod |
modified,fragment |
R4679 |
T7137 |
T7138 |
compound |
αCaMKII,promoter |
R4680 |
T7138 |
T7135 |
compound |
promoter,fragment |
R4681 |
T7139 |
T7138 |
punct |
-,promoter |
R4682 |
T7140 |
T7141 |
aux |
to,obtain |
R4683 |
T7141 |
T7129 |
advcl |
obtain,was |
R4684 |
T7142 |
T7143 |
amod |
high,selectivity |
R4685 |
T7143 |
T7141 |
dobj |
selectivity,obtain |
R4686 |
T7144 |
T7143 |
compound |
expression,selectivity |
R4687 |
T7145 |
T7146 |
punct |
(,5A |
R4688 |
T7146 |
T7129 |
parataxis |
5A,was |
R4689 |
T7147 |
T7146 |
compound |
Figure,5A |
R4690 |
T7148 |
T7146 |
punct |
;,5A |
R4691 |
T7149 |
T7146 |
advcl |
see,5A |
R4692 |
T7150 |
T7149 |
advmod |
also,see |
R4693 |
T7151 |
T7149 |
dobj |
Materials,see |
R4694 |
T7152 |
T7151 |
cc |
and,Materials |
R4695 |
T7153 |
T7151 |
conj |
Methods,Materials |
R4696 |
T7154 |
T7146 |
punct |
),5A |
R4697 |
T7155 |
T7129 |
punct |
.,was |
R4698 |
T7157 |
T7158 |
det |
The,level |
R4699 |
T7158 |
T7161 |
nsubj |
level,was |
R4700 |
T7159 |
T7158 |
amod |
transgenic,level |
R4701 |
T7160 |
T7158 |
compound |
expression,level |
R4702 |
T7162 |
T7158 |
prep |
of,level |
R4703 |
T7163 |
T7164 |
compound |
GFPGluR,B |
R4704 |
T7164 |
T7162 |
pobj |
B,of |
R4705 |
T7165 |
T7164 |
punct |
-,B |
R4706 |
T7166 |
T7167 |
nummod |
9.72,% |
R4707 |
T7167 |
T7161 |
attr |
%,was |
R4708 |
T7168 |
T7167 |
punct |
±,% |
R4709 |
T7169 |
T7167 |
appos |
1.25,% |
R4710 |
T7170 |
T7171 |
punct |
(,3 |
R4711 |
T7171 |
T7167 |
parataxis |
3,% |
R4712 |
T7172 |
T7171 |
nsubj |
n,3 |
R4713 |
T7173 |
T7171 |
punct |
=,3 |
R4714 |
T7174 |
T7171 |
punct |
),3 |
R4715 |
T7175 |
T7161 |
prep |
in,was |
R4716 |
T7176 |
T7177 |
det |
the,hippocampus |
R4717 |
T7177 |
T7175 |
pobj |
hippocampus,in |
R4718 |
T7178 |
T7161 |
punct |
", ",was |
R4719 |
T7179 |
T7161 |
prep |
compared,was |
R4720 |
T7180 |
T7179 |
prep |
with,compared |
R4721 |
T7181 |
T7182 |
amod |
endogenous,B |
R4722 |
T7182 |
T7180 |
pobj |
B,with |
R4723 |
T7183 |
T7182 |
compound |
GluR,B |
R4724 |
T7184 |
T7182 |
punct |
-,B |
R4725 |
T7185 |
T7186 |
punct |
(,5C |
R4726 |
T7186 |
T7161 |
parataxis |
5C,was |
R4727 |
T7187 |
T7186 |
compound |
Figure,5C |
R4728 |
T7188 |
T7186 |
cc |
and,5C |
R4729 |
T7189 |
T7186 |
conj |
5D,5C |
R4730 |
T7190 |
T7186 |
punct |
),5C |
R4731 |
T7191 |
T7161 |
punct |
.,was |
R4732 |
T7193 |
T7194 |
nsubj |
Analysis,revealed |
R4733 |
T7195 |
T7193 |
prep |
of,Analysis |
R4734 |
T7196 |
T7197 |
compound |
β,galactosidase |
R4735 |
T7197 |
T7199 |
compound |
galactosidase,activity |
R4736 |
T7198 |
T7197 |
punct |
-,galactosidase |
R4737 |
T7199 |
T7195 |
pobj |
activity,of |
R4738 |
T7200 |
T7199 |
cc |
and,activity |
R4739 |
T7201 |
T7202 |
compound |
GFPGluR,B |
R4740 |
T7202 |
T7204 |
compound |
B,expression |
R4741 |
T7203 |
T7202 |
punct |
-,B |
R4742 |
T7204 |
T7199 |
conj |
expression,activity |
R4743 |
T7205 |
T7199 |
prep |
in,activity |
R4744 |
T7206 |
T7207 |
compound |
brain,sections |
R4745 |
T7207 |
T7205 |
pobj |
sections,in |
R4746 |
T7208 |
T7207 |
prep |
of,sections |
R4747 |
T7209 |
T7210 |
compound |
GluR,BRescue |
R4748 |
T7210 |
T7212 |
compound |
BRescue,mice |
R4749 |
T7211 |
T7210 |
punct |
-,BRescue |
R4750 |
T7212 |
T7208 |
pobj |
mice,of |
R4751 |
T7213 |
T7194 |
dobj |
expression,revealed |
R4752 |
T7214 |
T7194 |
prep |
in,revealed |
R4753 |
T7215 |
T7214 |
pobj |
hippocampus,in |
R4754 |
T7216 |
T7215 |
cc |
and,hippocampus |
R4755 |
T7217 |
T7218 |
amod |
piriform,cortex |
R4756 |
T7218 |
T7215 |
conj |
cortex,hippocampus |
R4757 |
T7219 |
T7194 |
punct |
", ",revealed |
R4758 |
T7220 |
T7221 |
mark |
whereas,showed |
R4759 |
T7221 |
T7194 |
advcl |
showed,revealed |
R4760 |
T7222 |
T7221 |
nsubj |
cortex,showed |
R4761 |
T7223 |
T7222 |
punct |
", ",cortex |
R4762 |
T7224 |
T7222 |
conj |
amygdala,cortex |
R4763 |
T7225 |
T7224 |
punct |
", ",amygdala |
R4764 |
T7226 |
T7224 |
cc |
and,amygdala |
R4765 |
T7227 |
T7224 |
conj |
striatum,amygdala |
R4766 |
T7228 |
T7229 |
advmod |
only,rarely |
R4767 |
T7229 |
T7221 |
advmod |
rarely,showed |
R4768 |
T7230 |
T7231 |
det |
any,cells |
R4769 |
T7231 |
T7221 |
dobj |
cells,showed |
R4770 |
T7232 |
T7231 |
amod |
positive,cells |
R4771 |
T7233 |
T7234 |
punct |
(,5B |
R4772 |
T7234 |
T7194 |
parataxis |
5B,revealed |
R4773 |
T7235 |
T7234 |
compound |
Figure,5B |
R4774 |
T7236 |
T7234 |
punct |
),5B |
R4775 |
T7237 |
T7194 |
punct |
.,revealed |
R4776 |
T7239 |
T7240 |
advmod |
Importantly,were |
R4777 |
T7241 |
T7240 |
punct |
", ",were |
R4778 |
T7242 |
T7243 |
preconj |
both,pattern |
R4779 |
T7243 |
T7240 |
nsubj |
pattern,were |
R4780 |
T7244 |
T7243 |
det |
the,pattern |
R4781 |
T7245 |
T7243 |
amod |
spatial,pattern |
R4782 |
T7246 |
T7243 |
cc |
and,pattern |
R4783 |
T7247 |
T7243 |
conj |
intensity,pattern |
R4784 |
T7248 |
T7243 |
prep |
of,pattern |
R4785 |
T7249 |
T7250 |
compound |
GFPGluR,B |
R4786 |
T7250 |
T7252 |
compound |
B,expression |
R4787 |
T7251 |
T7250 |
punct |
-,B |
R4788 |
T7252 |
T7248 |
pobj |
expression,of |
R4789 |
T7253 |
T7240 |
acomp |
constant,were |
R4790 |
T7254 |
T7240 |
prep |
among,were |
R4791 |
T7255 |
T7256 |
det |
all,mice |
R4792 |
T7256 |
T7254 |
pobj |
mice,among |
R4793 |
T7257 |
T7258 |
compound |
GluR,BRescue |
R4794 |
T7258 |
T7256 |
compound |
BRescue,mice |
R4795 |
T7259 |
T7258 |
punct |
-,BRescue |
R4796 |
T7260 |
T7256 |
acl |
analyzed,mice |
R4797 |
T7261 |
T7262 |
punct |
(,11 |
R4798 |
T7262 |
T7240 |
parataxis |
11,were |
R4799 |
T7263 |
T7262 |
nsubj |
n,11 |
R4800 |
T7264 |
T7262 |
punct |
=,11 |
R4801 |
T7265 |
T7262 |
punct |
),11 |
R4802 |
T7266 |
T7240 |
punct |
.,were |
R4803 |
T7268 |
T7269 |
amod |
Olfactory,memory |
R4804 |
T7269 |
T7270 |
compound |
memory,experiments |
R4805 |
T7270 |
T7271 |
nsubjpass |
experiments,performed |
R4806 |
T7272 |
T7270 |
prep |
with,experiments |
R4807 |
T7273 |
T7274 |
compound |
GluR,BRescue |
R4808 |
T7274 |
T7272 |
pobj |
BRescue,with |
R4809 |
T7275 |
T7274 |
punct |
-,BRescue |
R4810 |
T7276 |
T7274 |
punct |
", ",BRescue |
R4811 |
T7277 |
T7274 |
cc |
and,BRescue |
R4812 |
T7278 |
T7279 |
preconj |
both,BΔFB |
R4813 |
T7279 |
T7282 |
nmod |
BΔFB,mice |
R4814 |
T7280 |
T7279 |
nmod |
GluR,BΔFB |
R4815 |
T7281 |
T7279 |
punct |
-,BΔFB |
R4816 |
T7282 |
T7274 |
conj |
mice,BRescue |
R4817 |
T7283 |
T7279 |
cc |
and,BΔFB |
R4818 |
T7284 |
T7285 |
compound |
GluR,B2lox |
R4819 |
T7285 |
T7279 |
conj |
B2lox,BΔFB |
R4820 |
T7286 |
T7285 |
punct |
-,B2lox |
R4821 |
T7287 |
T7282 |
prep |
as,mice |
R4822 |
T7288 |
T7287 |
pobj |
controls,as |
R4823 |
T7289 |
T7271 |
punct |
", ",performed |
R4824 |
T7290 |
T7271 |
auxpass |
were,performed |
R4825 |
T7291 |
T7292 |
mark |
as,described |
R4826 |
T7292 |
T7271 |
advcl |
described,performed |
R4827 |
T7293 |
T7292 |
advmod |
above,described |
R4828 |
T7294 |
T7295 |
punct |
(,indicated |
R4829 |
T7295 |
T7271 |
parataxis |
indicated,performed |
R4830 |
T7296 |
T7295 |
prep |
with,indicated |
R4831 |
T7297 |
T7298 |
amod |
shaded,symbols |
R4832 |
T7298 |
T7296 |
pobj |
symbols,with |
R4833 |
T7299 |
T7295 |
prep |
in,indicated |
R4834 |
T7300 |
T7301 |
compound |
Figure,6A |
R4835 |
T7301 |
T7299 |
pobj |
6A,in |
R4836 |
T7302 |
T7295 |
punct |
),indicated |
R4837 |
T7303 |
T7271 |
punct |
.,performed |
R4838 |
T7305 |
T7306 |
nsubj |
Memory,was |
R4839 |
T7307 |
T7306 |
advmod |
again,was |
R4840 |
T7308 |
T7309 |
advmod |
highly,reproducible |
R4841 |
T7309 |
T7306 |
acomp |
reproducible,was |
R4842 |
T7310 |
T7306 |
prep |
in,was |
R4843 |
T7311 |
T7312 |
preconj |
both,BΔFB |
R4844 |
T7312 |
T7315 |
nmod |
BΔFB,mice |
R4845 |
T7313 |
T7312 |
nmod |
GluR,BΔFB |
R4846 |
T7314 |
T7312 |
punct |
-,BΔFB |
R4847 |
T7315 |
T7310 |
pobj |
mice,in |
R4848 |
T7316 |
T7317 |
punct |
(,% |
R4849 |
T7317 |
T7312 |
parataxis |
%,BΔFB |
R4850 |
T7318 |
T7319 |
quantmod |
66,12 |
R4851 |
T7319 |
T7317 |
nummod |
12,% |
R4852 |
T7320 |
T7319 |
punct |
±,12 |
R4853 |
T7321 |
T7317 |
punct |
;,% |
R4854 |
T7322 |
T7323 |
nsubj |
n,4 |
R4855 |
T7323 |
T7317 |
ccomp |
4,% |
R4856 |
T7324 |
T7323 |
punct |
=,4 |
R4857 |
T7325 |
T7317 |
punct |
),% |
R4858 |
T7326 |
T7312 |
cc |
and,BΔFB |
R4859 |
T7327 |
T7328 |
compound |
GluR,B2lox |
R4860 |
T7328 |
T7312 |
conj |
B2lox,BΔFB |
R4861 |
T7329 |
T7328 |
punct |
-,B2lox |
R4862 |
T7330 |
T7331 |
punct |
(,% |
R4863 |
T7331 |
T7328 |
parataxis |
%,B2lox |
R4864 |
T7332 |
T7333 |
quantmod |
94,2 |
R4865 |
T7333 |
T7331 |
nummod |
2,% |
R4866 |
T7334 |
T7333 |
punct |
±,2 |
R4867 |
T7335 |
T7331 |
punct |
;,% |
R4868 |
T7336 |
T7337 |
nsubj |
n,3 |
R4869 |
T7337 |
T7331 |
ccomp |
3,% |
R4870 |
T7338 |
T7337 |
punct |
=,3 |
R4871 |
T7339 |
T7331 |
punct |
),% |
R4872 |
T7340 |
T7306 |
punct |
", ",was |
R4873 |
T7341 |
T7306 |
prep |
compared,was |
R4874 |
T7342 |
T7341 |
prep |
with,compared |
R4875 |
T7343 |
T7342 |
pobj |
experiments,with |
R4876 |
T7344 |
T7343 |
acl |
performed,experiments |
R4877 |
T7345 |
T7344 |
advmod |
earlier,performed |
R4878 |
T7346 |
T7347 |
punct |
(,2E |
R4879 |
T7347 |
T7306 |
parataxis |
2E,was |
R4880 |
T7348 |
T7347 |
compound |
Figures,2E |
R4881 |
T7349 |
T7347 |
cc |
and,2E |
R4882 |
T7350 |
T7347 |
conj |
4A,2E |
R4883 |
T7351 |
T7347 |
punct |
),2E |
R4884 |
T7352 |
T7306 |
punct |
.,was |
R4885 |
T7354 |
T7355 |
advmod |
Importantly,was |
R4886 |
T7356 |
T7355 |
punct |
", ",was |
R4887 |
T7357 |
T7358 |
amod |
olfactory,memory |
R4888 |
T7358 |
T7355 |
nsubj |
memory,was |
R4889 |
T7359 |
T7358 |
prep |
in,memory |
R4890 |
T7360 |
T7361 |
compound |
GluR,BRescue |
R4891 |
T7361 |
T7363 |
compound |
BRescue,mice |
R4892 |
T7362 |
T7361 |
punct |
-,BRescue |
R4893 |
T7363 |
T7359 |
pobj |
mice,in |
R4894 |
T7364 |
T7355 |
acomp |
intermediate,was |
R4895 |
T7365 |
T7366 |
punct |
(,% |
R4896 |
T7366 |
T7364 |
parataxis |
%,intermediate |
R4897 |
T7367 |
T7368 |
quantmod |
75,15 |
R4898 |
T7368 |
T7366 |
nummod |
15,% |
R4899 |
T7369 |
T7368 |
punct |
±,15 |
R4900 |
T7370 |
T7366 |
punct |
", ",% |
R4901 |
T7371 |
T7372 |
nsubj |
n,8 |
R4902 |
T7372 |
T7366 |
ccomp |
8,% |
R4903 |
T7373 |
T7372 |
punct |
=,8 |
R4904 |
T7374 |
T7366 |
punct |
),% |
R4905 |
T7375 |
T7364 |
punct |
", ",intermediate |
R4906 |
T7376 |
T7364 |
conj |
below,intermediate |
R4907 |
T7377 |
T7378 |
compound |
GluR,B2lox |
R4908 |
T7378 |
T7380 |
compound |
B2lox,levels |
R4909 |
T7379 |
T7378 |
punct |
-,B2lox |
R4910 |
T7380 |
T7376 |
pobj |
levels,below |
R4911 |
T7381 |
T7380 |
compound |
control,levels |
R4912 |
T7382 |
T7376 |
punct |
", ",below |
R4913 |
T7383 |
T7376 |
cc |
but,below |
R4914 |
T7384 |
T7376 |
conj |
better,below |
R4915 |
T7385 |
T7384 |
prep |
than,better |
R4916 |
T7386 |
T7385 |
prep |
in,than |
R4917 |
T7387 |
T7388 |
compound |
GluR,BΔFB |
R4918 |
T7388 |
T7390 |
compound |
BΔFB,mice |
R4919 |
T7389 |
T7388 |
punct |
-,BΔFB |
R4920 |
T7390 |
T7386 |
pobj |
mice,in |
R4921 |
T7391 |
T7355 |
punct |
.,was |
R4922 |
T7393 |
T7394 |
csubj |
Assessing,confirmed |
R4923 |
T7395 |
T7393 |
dobj |
memory,Assessing |
R4924 |
T7396 |
T7393 |
prep |
under,Assessing |
R4925 |
T7397 |
T7398 |
npadvmod |
extinction,free |
R4926 |
T7398 |
T7400 |
amod |
free,condition |
R4927 |
T7399 |
T7398 |
punct |
-,free |
R4928 |
T7400 |
T7396 |
pobj |
condition,under |
R4929 |
T7401 |
T7393 |
punct |
", ",Assessing |
R4930 |
T7402 |
T7403 |
advmod |
where,rewarded |
R4931 |
T7403 |
T7393 |
advcl |
rewarded,Assessing |
R4932 |
T7404 |
T7405 |
det |
each,trial |
R4933 |
T7405 |
T7403 |
nsubjpass |
trial,rewarded |
R4934 |
T7406 |
T7403 |
auxpass |
was,rewarded |
R4935 |
T7407 |
T7394 |
punct |
", ",confirmed |
R4936 |
T7408 |
T7394 |
advmod |
again,confirmed |
R4937 |
T7409 |
T7410 |
mark |
that,was |
R4938 |
T7410 |
T7394 |
ccomp |
was,confirmed |
R4939 |
T7411 |
T7412 |
det |
the,deficit |
R4940 |
T7412 |
T7410 |
nsubj |
deficit,was |
R4941 |
T7413 |
T7412 |
compound |
memory,deficit |
R4942 |
T7414 |
T7415 |
det |
a,deficit |
R4943 |
T7415 |
T7410 |
attr |
deficit,was |
R4944 |
T7416 |
T7415 |
amod |
true,deficit |
R4945 |
T7417 |
T7415 |
compound |
memory,deficit |
R4946 |
T7418 |
T7415 |
cc |
and,deficit |
R4947 |
T7419 |
T7418 |
neg |
not,and |
R4948 |
T7420 |
T7415 |
conj |
due,deficit |
R4949 |
T7421 |
T7420 |
pcomp |
to,due |
R4950 |
T7422 |
T7423 |
amod |
increased,extinction |
R4951 |
T7423 |
T7420 |
pobj |
extinction,due |
R4952 |
T7424 |
T7425 |
punct |
(,S3B |
R4953 |
T7425 |
T7394 |
parataxis |
S3B,confirmed |
R4954 |
T7426 |
T7425 |
compound |
Figure,S3B |
R4955 |
T7427 |
T7425 |
punct |
),S3B |
R4956 |
T7428 |
T7394 |
punct |
.,confirmed |
R4957 |
T7430 |
T7431 |
nsubjpass |
Data,combined |
R4958 |
T7432 |
T7430 |
prep |
from,Data |
R4959 |
T7433 |
T7434 |
det |
the,experiments |
R4960 |
T7434 |
T7432 |
pobj |
experiments,from |
R4961 |
T7435 |
T7434 |
acl |
described,experiments |
R4962 |
T7436 |
T7435 |
prep |
in,described |
R4963 |
T7437 |
T7438 |
nmod |
Figures,2 |
R4964 |
T7438 |
T7436 |
pobj |
2,in |
R4965 |
T7439 |
T7438 |
cc |
and,2 |
R4966 |
T7440 |
T7438 |
conj |
4,2 |
R4967 |
T7441 |
T7431 |
auxpass |
were,combined |
R4968 |
T7442 |
T7443 |
aux |
to,allow |
R4969 |
T7443 |
T7431 |
advcl |
allow,combined |
R4970 |
T7444 |
T7445 |
amod |
statistical,comparison |
R4971 |
T7445 |
T7443 |
dobj |
comparison,allow |
R4972 |
T7446 |
T7447 |
punct |
(,6A |
R4973 |
T7447 |
T7431 |
parataxis |
6A,combined |
R4974 |
T7448 |
T7447 |
compound |
Figure,6A |
R4975 |
T7449 |
T7447 |
cc |
and,6A |
R4976 |
T7450 |
T7447 |
conj |
6B,6A |
R4977 |
T7451 |
T7447 |
punct |
),6A |
R4978 |
T7452 |
T7431 |
punct |
.,combined |
R4979 |
T7454 |
T7455 |
prep |
In,showed |
R4980 |
T7456 |
T7454 |
pobj |
summary,In |
R4981 |
T7457 |
T7455 |
punct |
", ",showed |
R4982 |
T7458 |
T7459 |
compound |
GluR,BRescue |
R4983 |
T7459 |
T7461 |
compound |
BRescue,mice |
R4984 |
T7460 |
T7459 |
punct |
-,BRescue |
R4985 |
T7461 |
T7455 |
nsubj |
mice,showed |
R4986 |
T7462 |
T7463 |
det |
both,performances |
R4987 |
T7463 |
T7455 |
dobj |
performances,showed |
R4988 |
T7464 |
T7465 |
amod |
enhanced,memory |
R4989 |
T7465 |
T7463 |
compound |
memory,performances |
R4990 |
T7466 |
T7455 |
prep |
compared,showed |
R4991 |
T7467 |
T7466 |
prep |
with,compared |
R4992 |
T7468 |
T7469 |
compound |
GluR,BΔFB |
R4993 |
T7469 |
T7467 |
pobj |
BΔFB,with |
R4994 |
T7470 |
T7469 |
punct |
-,BΔFB |
R4995 |
T7471 |
T7472 |
punct |
(,6A |
R4996 |
T7472 |
T7455 |
parataxis |
6A,showed |
R4997 |
T7473 |
T7474 |
amod |
overall,ANOVA |
R4998 |
T7474 |
T7472 |
dep |
ANOVA,6A |
R4999 |
T7475 |
T7472 |
punct |
: ,6A |
R5000 |
T7476 |
T7477 |
nsubj |
F,13.6 |
R5001 |
T7477 |
T7472 |
ccomp |
13.6,6A |
R5002 |
T7478 |
T7476 |
punct |
(,F |
R5003 |
T7479 |
T7476 |
nummod |
2,F |
R5004 |
T7480 |
T7476 |
punct |
",",F |
R5005 |
T7481 |
T7476 |
nummod |
41,F |
R5006 |
T7482 |
T7476 |
punct |
),F |
R5007 |
T7483 |
T7477 |
punct |
=,13.6 |
R5008 |
T7484 |
T7472 |
punct |
", ",6A |
R5009 |
T7485 |
T7486 |
nsubj |
p,4 |
R5010 |
T7486 |
T7472 |
ccomp |
4,6A |
R5011 |
T7487 |
T7486 |
punct |
<,4 |
R5012 |
T7488 |
T7486 |
quantmod |
10,4 |
R5013 |
T7489 |
T7486 |
punct |
−,4 |
R5014 |
T7490 |
T7472 |
punct |
;,6A |
R5015 |
T7491 |
T7492 |
nsubj |
memoryRescue,% |
R5016 |
T7492 |
T7472 |
ccomp |
%,6A |
R5017 |
T7493 |
T7492 |
punct |
=,% |
R5018 |
T7494 |
T7495 |
quantmod |
75,15 |
R5019 |
T7495 |
T7492 |
nummod |
15,% |
R5020 |
T7496 |
T7495 |
punct |
±,15 |
R5021 |
T7497 |
T7472 |
punct |
", ",6A |
R5022 |
T7498 |
T7499 |
nsubj |
n,8 |
R5023 |
T7499 |
T7472 |
ccomp |
8,6A |
R5024 |
T7500 |
T7499 |
punct |
=,8 |
R5025 |
T7501 |
T7472 |
punct |
;,6A |
R5026 |
T7502 |
T7503 |
nsubj |
memoryΔFB,% |
R5027 |
T7503 |
T7472 |
ccomp |
%,6A |
R5028 |
T7504 |
T7503 |
punct |
=,% |
R5029 |
T7505 |
T7506 |
quantmod |
66,14 |
R5030 |
T7506 |
T7503 |
nummod |
14,% |
R5031 |
T7507 |
T7506 |
punct |
±,14 |
R5032 |
T7508 |
T7472 |
punct |
", ",6A |
R5033 |
T7509 |
T7510 |
nsubj |
n,22 |
R5034 |
T7510 |
T7472 |
ccomp |
22,6A |
R5035 |
T7511 |
T7510 |
punct |
=,22 |
R5036 |
T7512 |
T7472 |
punct |
;,6A |
R5037 |
T7513 |
T7514 |
nsubj |
p,0.05 |
R5038 |
T7514 |
T7472 |
ccomp |
0.05,6A |
R5039 |
T7515 |
T7514 |
punct |
<,0.05 |
R5040 |
T7516 |
T7472 |
punct |
;,6A |
R5041 |
T7517 |
T7472 |
compound |
Figure,6A |
R5042 |
T7518 |
T7472 |
punct |
),6A |
R5043 |
T7519 |
T7455 |
punct |
", ",showed |
R5044 |
T7520 |
T7455 |
cc |
but,showed |
R5045 |
T7521 |
T7522 |
auxpass |
were,impaired |
R5046 |
T7522 |
T7455 |
conj |
impaired,showed |
R5047 |
T7523 |
T7522 |
advmod |
still,impaired |
R5048 |
T7524 |
T7522 |
advcl |
relative,impaired |
R5049 |
T7525 |
T7524 |
prep |
to,relative |
R5050 |
T7526 |
T7527 |
compound |
GluR,B2lox |
R5051 |
T7527 |
T7529 |
compound |
B2lox,controls |
R5052 |
T7528 |
T7527 |
punct |
-,B2lox |
R5053 |
T7529 |
T7525 |
pobj |
controls,to |
R5054 |
T7530 |
T7531 |
punct |
(,0.005 |
R5055 |
T7531 |
T7522 |
parataxis |
0.005,impaired |
R5056 |
T7532 |
T7533 |
nsubj |
memory2lox,% |
R5057 |
T7533 |
T7531 |
ccomp |
%,0.005 |
R5058 |
T7534 |
T7533 |
punct |
=,% |
R5059 |
T7535 |
T7536 |
quantmod |
88,8 |
R5060 |
T7536 |
T7533 |
nummod |
8,% |
R5061 |
T7537 |
T7536 |
punct |
±,8 |
R5062 |
T7538 |
T7531 |
punct |
", ",0.005 |
R5063 |
T7539 |
T7540 |
nsubj |
n,14 |
R5064 |
T7540 |
T7531 |
ccomp |
14,0.005 |
R5065 |
T7541 |
T7540 |
punct |
=,14 |
R5066 |
T7542 |
T7531 |
punct |
;,0.005 |
R5067 |
T7543 |
T7531 |
nsubj |
p,0.005 |
R5068 |
T7544 |
T7531 |
punct |
<,0.005 |
R5069 |
T7545 |
T7531 |
punct |
),0.005 |
R5070 |
T7546 |
T7455 |
punct |
", ",showed |
R5071 |
T7547 |
T7455 |
advcl |
consistent,showed |
R5072 |
T7548 |
T7547 |
prep |
with,consistent |
R5073 |
T7549 |
T7550 |
det |
a,rescue |
R5074 |
T7550 |
T7548 |
pobj |
rescue,with |
R5075 |
T7551 |
T7550 |
amod |
partial,rescue |
R5076 |
T7552 |
T7550 |
prep |
of,rescue |
R5077 |
T7553 |
T7554 |
det |
the,deficit |
R5078 |
T7554 |
T7552 |
pobj |
deficit,of |
R5079 |
T7555 |
T7554 |
compound |
memory,deficit |
R5080 |
T7556 |
T7550 |
prep |
by,rescue |
R5081 |
T7557 |
T7558 |
amod |
circumscribed,expression |
R5082 |
T7558 |
T7556 |
pobj |
expression,by |
R5083 |
T7559 |
T7558 |
amod |
transgenic,expression |
R5084 |
T7560 |
T7561 |
compound |
GFPGluR,B |
R5085 |
T7561 |
T7558 |
compound |
B,expression |
R5086 |
T7562 |
T7561 |
punct |
-,B |
R5087 |
T7563 |
T7550 |
prep |
in,rescue |
R5088 |
T7564 |
T7563 |
pobj |
hippocampus,in |
R5089 |
T7565 |
T7564 |
cc |
and,hippocampus |
R5090 |
T7566 |
T7567 |
amod |
piriform,cortex |
R5091 |
T7567 |
T7564 |
conj |
cortex,hippocampus |
R5092 |
T7568 |
T7455 |
punct |
.,showed |
R5093 |
T7570 |
T7571 |
advmod |
Notably,is |
R5094 |
T7572 |
T7571 |
punct |
", ",is |
R5095 |
T7573 |
T7574 |
det |
the,memory |
R5096 |
T7574 |
T7571 |
nsubj |
memory,is |
R5097 |
T7575 |
T7574 |
amod |
partial,memory |
R5098 |
T7576 |
T7571 |
prep |
in,is |
R5099 |
T7577 |
T7578 |
amod |
numerical,agreement |
R5100 |
T7578 |
T7576 |
pobj |
agreement,in |
R5101 |
T7579 |
T7578 |
prep |
with,agreement |
R5102 |
T7580 |
T7581 |
det |
the,predictions |
R5103 |
T7581 |
T7579 |
pobj |
predictions,with |
R5104 |
T7582 |
T7581 |
prep |
from,predictions |
R5105 |
T7583 |
T7584 |
det |
the,correlation |
R5106 |
T7584 |
T7582 |
pobj |
correlation,from |
R5107 |
T7585 |
T7584 |
compound |
protein,correlation |
R5108 |
T7586 |
T7581 |
cc |
and,predictions |
R5109 |
T7587 |
T7588 |
det |
the,measurement |
R5110 |
T7588 |
T7581 |
conj |
measurement,predictions |
R5111 |
T7589 |
T7588 |
prep |
of,measurement |
R5112 |
T7590 |
T7591 |
amod |
transgenic,expression |
R5113 |
T7591 |
T7589 |
pobj |
expression,of |
R5114 |
T7592 |
T7591 |
compound |
protein,expression |
R5115 |
T7593 |
T7594 |
punct |
(,see |
R5116 |
T7594 |
T7578 |
parataxis |
see,agreement |
R5117 |
T7595 |
T7596 |
amod |
predicted,memory |
R5118 |
T7596 |
T7594 |
dobj |
memory,see |
R5119 |
T7597 |
T7596 |
punct |
", ",memory |
R5120 |
T7598 |
T7599 |
amod |
blue,line |
R5121 |
T7599 |
T7596 |
appos |
line,memory |
R5122 |
T7600 |
T7599 |
punct |
", ",line |
R5123 |
T7601 |
T7599 |
prep |
in,line |
R5124 |
T7602 |
T7603 |
compound |
Figure,6B |
R5125 |
T7603 |
T7601 |
pobj |
6B,in |
R5126 |
T7604 |
T7594 |
punct |
),see |
R5127 |
T7605 |
T7571 |
punct |
.,is |
R5128 |
T7607 |
T7608 |
prep |
In,depended |
R5129 |
T7609 |
T7610 |
det |
the,experiments |
R5130 |
T7610 |
T7607 |
pobj |
experiments,In |
R5131 |
T7611 |
T7612 |
amod |
olfactory,memory |
R5132 |
T7612 |
T7610 |
compound |
memory,experiments |
R5133 |
T7613 |
T7610 |
prep |
with,experiments |
R5134 |
T7614 |
T7615 |
compound |
GluR,BΔFB |
R5135 |
T7615 |
T7617 |
compound |
BΔFB,animals |
R5136 |
T7616 |
T7615 |
punct |
-,BΔFB |
R5137 |
T7617 |
T7613 |
pobj |
animals,with |
R5138 |
T7618 |
T7608 |
punct |
", ",depended |
R5139 |
T7619 |
T7620 |
amod |
olfactory,memory |
R5140 |
T7620 |
T7608 |
nsubj |
memory,depended |
R5141 |
T7621 |
T7608 |
advmod |
linearly,depended |
R5142 |
T7622 |
T7608 |
prep |
on,depended |
R5143 |
T7623 |
T7624 |
compound |
GluR,B |
R5144 |
T7624 |
T7626 |
compound |
B,expression |
R5145 |
T7625 |
T7624 |
punct |
-,B |
R5146 |
T7626 |
T7622 |
pobj |
expression,on |
R5147 |
T7627 |
T7608 |
prep |
in,depended |
R5148 |
T7628 |
T7627 |
pobj |
cortex,in |
R5149 |
T7629 |
T7628 |
cc |
and,cortex |
R5150 |
T7630 |
T7628 |
conj |
hippocampus,cortex |
R5151 |
T7631 |
T7608 |
prep |
with,depended |
R5152 |
T7632 |
T7633 |
det |
a,slope |
R5153 |
T7633 |
T7631 |
pobj |
slope,with |
R5154 |
T7634 |
T7633 |
prep |
of,slope |
R5155 |
T7635 |
T7636 |
quantmod |
9.1,2.5 |
R5156 |
T7636 |
T7638 |
nummod |
2.5,% |
R5157 |
T7637 |
T7636 |
punct |
±,2.5 |
R5158 |
T7638 |
T7634 |
pobj |
%,of |
R5159 |
T7639 |
T7640 |
punct |
(,cortex |
R5160 |
T7640 |
T7634 |
parataxis |
cortex,of |
R5161 |
T7641 |
T7640 |
punct |
),cortex |
R5162 |
T7642 |
T7633 |
cc |
and,slope |
R5163 |
T7643 |
T7644 |
quantmod |
8.9,2.0 |
R5164 |
T7644 |
T7646 |
nummod |
2.0,% |
R5165 |
T7645 |
T7644 |
punct |
±,2.0 |
R5166 |
T7646 |
T7647 |
nmod |
%,increase |
R5167 |
T7647 |
T7633 |
conj |
increase,slope |
R5168 |
T7648 |
T7649 |
punct |
(,hippocampus |
R5169 |
T7649 |
T7647 |
parataxis |
hippocampus,increase |
R5170 |
T7650 |
T7649 |
punct |
),hippocampus |
R5171 |
T7651 |
T7647 |
prep |
in,increase |
R5172 |
T7652 |
T7651 |
pobj |
memory,in |
R5173 |
T7653 |
T7647 |
prep |
per,increase |
R5174 |
T7654 |
T7655 |
nummod |
10,% |
R5175 |
T7655 |
T7656 |
compound |
%,increase |
R5176 |
T7656 |
T7653 |
pobj |
increase,per |
R5177 |
T7657 |
T7656 |
prep |
in,increase |
R5178 |
T7658 |
T7657 |
pobj |
protein,in |
R5179 |
T7659 |
T7660 |
punct |
(,4D |
R5180 |
T7660 |
T7631 |
parataxis |
4D,with |
R5181 |
T7661 |
T7660 |
compound |
Figure,4D |
R5182 |
T7662 |
T7660 |
punct |
),4D |
R5183 |
T7663 |
T7608 |
punct |
.,depended |
R5184 |
T7665 |
T7666 |
det |
A,increase |
R5185 |
T7666 |
T7669 |
nsubjpass |
increase,predicted |
R5186 |
T7667 |
T7668 |
nummod |
9.7,% |
R5187 |
T7668 |
T7666 |
compound |
%,increase |
R5188 |
T7670 |
T7666 |
prep |
in,increase |
R5189 |
T7671 |
T7672 |
compound |
GluR,B |
R5190 |
T7672 |
T7670 |
pobj |
B,in |
R5191 |
T7673 |
T7672 |
punct |
-,B |
R5192 |
T7674 |
T7666 |
prep |
in,increase |
R5193 |
T7675 |
T7676 |
det |
these,regions |
R5194 |
T7676 |
T7674 |
pobj |
regions,in |
R5195 |
T7677 |
T7676 |
compound |
brain,regions |
R5196 |
T7678 |
T7666 |
punct |
", ",increase |
R5197 |
T7679 |
T7680 |
mark |
as,achieved |
R5198 |
T7680 |
T7666 |
advcl |
achieved,increase |
R5199 |
T7681 |
T7680 |
agent |
by,achieved |
R5200 |
T7682 |
T7683 |
compound |
GluR,BRescue |
R5201 |
T7683 |
T7685 |
compound |
BRescue,animals |
R5202 |
T7684 |
T7683 |
punct |
-,BRescue |
R5203 |
T7685 |
T7681 |
pobj |
animals,by |
R5204 |
T7686 |
T7687 |
punct |
(,Figure |
R5205 |
T7687 |
T7680 |
parataxis |
Figure,achieved |
R5206 |
T7688 |
T7687 |
nummod |
5,Figure |
R5207 |
T7689 |
T7687 |
punct |
),Figure |
R5208 |
T7690 |
T7669 |
punct |
", ",predicted |
R5209 |
T7691 |
T7669 |
auxpass |
is,predicted |
R5210 |
T7692 |
T7669 |
advmod |
thus,predicted |
R5211 |
T7693 |
T7694 |
aux |
to,increase |
R5212 |
T7694 |
T7669 |
xcomp |
increase,predicted |
R5213 |
T7695 |
T7696 |
amod |
olfactory,memory |
R5214 |
T7696 |
T7694 |
dobj |
memory,increase |
R5215 |
T7697 |
T7694 |
prep |
by,increase |
R5216 |
T7698 |
T7699 |
advmod |
approximately,9 |
R5217 |
T7699 |
T7700 |
nummod |
9,% |
R5218 |
T7700 |
T7697 |
pobj |
%,by |
R5219 |
T7701 |
T7694 |
prep |
throughout,increase |
R5220 |
T7702 |
T7703 |
det |
the,population |
R5221 |
T7703 |
T7701 |
pobj |
population,throughout |
R5222 |
T7704 |
T7703 |
amod |
heterogeneous,population |
R5223 |
T7705 |
T7706 |
punct |
(,line |
R5224 |
T7706 |
T7669 |
parataxis |
line,predicted |
R5225 |
T7707 |
T7706 |
amod |
blue,line |
R5226 |
T7708 |
T7706 |
prep |
in,line |
R5227 |
T7709 |
T7710 |
compound |
Figure,6B |
R5228 |
T7710 |
T7708 |
pobj |
6B,in |
R5229 |
T7711 |
T7706 |
punct |
),line |
R5230 |
T7712 |
T7669 |
punct |
.,predicted |
R5231 |
T7714 |
T7715 |
nsubj |
This,confirms |
R5232 |
T7716 |
T7717 |
det |
the,role |
R5233 |
T7717 |
T7715 |
dobj |
role,confirms |
R5234 |
T7718 |
T7717 |
prep |
of,role |
R5235 |
T7719 |
T7720 |
det |
these,areas |
R5236 |
T7720 |
T7718 |
pobj |
areas,of |
R5237 |
T7721 |
T7720 |
compound |
brain,areas |
R5238 |
T7722 |
T7723 |
mark |
as,inferred |
R5239 |
T7723 |
T7717 |
advcl |
inferred,role |
R5240 |
T7724 |
T7723 |
prep |
from,inferred |
R5241 |
T7725 |
T7726 |
det |
the,expression |
R5242 |
T7726 |
T7724 |
pobj |
expression,from |
R5243 |
T7727 |
T7726 |
amod |
mosaic,expression |
R5244 |
T7728 |
T7726 |
cc |
and,expression |
R5245 |
T7729 |
T7730 |
compound |
protein,analysis |
R5246 |
T7730 |
T7726 |
conj |
analysis,expression |
R5247 |
T7731 |
T7730 |
compound |
correlation,analysis |
R5248 |
T7732 |
T7726 |
acl |
described,expression |
R5249 |
T7733 |
T7732 |
advmod |
above,described |
R5250 |
T7734 |
T7735 |
punct |
(,Figure |
R5251 |
T7735 |
T7717 |
parataxis |
Figure,role |
R5252 |
T7736 |
T7735 |
nummod |
4,Figure |
R5253 |
T7737 |
T7735 |
punct |
),Figure |
R5254 |
T7738 |
T7715 |
punct |
.,confirms |
R5255 |
T7740 |
T7741 |
advmod |
However,was |
R5256 |
T7742 |
T7741 |
punct |
", ",was |
R5257 |
T7743 |
T7744 |
compound |
odor,discrimination |
R5258 |
T7744 |
T7741 |
nsubj |
discrimination,was |
R5259 |
T7745 |
T7744 |
punct |
(,discrimination |
R5260 |
T7746 |
T7744 |
acl |
measured,discrimination |
R5261 |
T7747 |
T7746 |
prep |
by,measured |
R5262 |
T7748 |
T7749 |
det |
the,index |
R5263 |
T7749 |
T7747 |
pobj |
index,by |
R5264 |
T7750 |
T7749 |
compound |
discrimination,index |
R5265 |
T7751 |
T7746 |
prep |
as,measured |
R5266 |
T7752 |
T7751 |
prep |
in,as |
R5267 |
T7753 |
T7754 |
nmod |
Figures,4D |
R5268 |
T7754 |
T7752 |
pobj |
4D,in |
R5269 |
T7755 |
T7754 |
nummod |
1,4D |
R5270 |
T7756 |
T7754 |
punct |
", ",4D |
R5271 |
T7757 |
T7754 |
nummod |
2,4D |
R5272 |
T7758 |
T7754 |
punct |
", ",4D |
R5273 |
T7759 |
T7754 |
cc |
and,4D |
R5274 |
T7760 |
T7741 |
punct |
),was |
R5275 |
T7761 |
T7762 |
advmod |
as,enhanced |
R5276 |
T7762 |
T7741 |
acomp |
enhanced,was |
R5277 |
T7763 |
T7762 |
prep |
as,enhanced |
R5278 |
T7764 |
T7763 |
prep |
in,as |
R5279 |
T7765 |
T7766 |
compound |
GluR,BΔFB |
R5280 |
T7766 |
T7768 |
compound |
BΔFB,mice |
R5281 |
T7767 |
T7766 |
punct |
-,BΔFB |
R5282 |
T7768 |
T7764 |
pobj |
mice,in |
R5283 |
T7769 |
T7770 |
punct |
(,6C |
R5284 |
T7770 |
T7741 |
parataxis |
6C,was |
R5285 |
T7771 |
T7772 |
nummod |
0.79,0.05 |
R5286 |
T7772 |
T7770 |
dep |
0.05,6C |
R5287 |
T7773 |
T7772 |
punct |
±,0.05 |
R5288 |
T7774 |
T7770 |
punct |
", ",6C |
R5289 |
T7775 |
T7776 |
nmod |
mean,SEM |
R5290 |
T7776 |
T7770 |
dep |
SEM,6C |
R5291 |
T7777 |
T7776 |
punct |
±,SEM |
R5292 |
T7778 |
T7776 |
prep |
compared,SEM |
R5293 |
T7779 |
T7778 |
prep |
with,compared |
R5294 |
T7780 |
T7781 |
nummod |
0.76,0.02 |
R5295 |
T7781 |
T7779 |
pobj |
0.02,with |
R5296 |
T7782 |
T7781 |
punct |
±,0.02 |
R5297 |
T7783 |
T7770 |
punct |
", ",6C |
R5298 |
T7784 |
T7785 |
nsubj |
p,0.7 |
R5299 |
T7785 |
T7770 |
ccomp |
0.7,6C |
R5300 |
T7786 |
T7785 |
punct |
>,0.7 |
R5301 |
T7787 |
T7770 |
punct |
", ",6C |
R5302 |
T7788 |
T7770 |
compound |
Figure,6C |
R5303 |
T7789 |
T7770 |
punct |
),6C |
R5304 |
T7790 |
T7741 |
punct |
", ",was |
R5305 |
T7791 |
T7741 |
cc |
and,was |
R5306 |
T7792 |
T7741 |
conj |
improved,was |
R5307 |
T7793 |
T7792 |
advcl |
relative,improved |
R5308 |
T7794 |
T7793 |
prep |
to,relative |
R5309 |
T7795 |
T7796 |
compound |
GluR,B2lox |
R5310 |
T7796 |
T7798 |
compound |
B2lox,controls |
R5311 |
T7797 |
T7796 |
punct |
-,B2lox |
R5312 |
T7798 |
T7794 |
pobj |
controls,to |
R5313 |
T7799 |
T7800 |
punct |
(,6C |
R5314 |
T7800 |
T7792 |
parataxis |
6C,improved |
R5315 |
T7801 |
T7802 |
nummod |
0.48,0.06 |
R5316 |
T7802 |
T7800 |
dep |
0.06,6C |
R5317 |
T7803 |
T7802 |
punct |
±,0.06 |
R5318 |
T7804 |
T7800 |
punct |
;,6C |
R5319 |
T7805 |
T7800 |
compound |
Figure,6C |
R5320 |
T7806 |
T7800 |
punct |
;,6C |
R5321 |
T7807 |
T7808 |
amod |
overall,ANOVA |
R5322 |
T7808 |
T7809 |
dep |
ANOVA,10 |
R5323 |
T7809 |
T7800 |
dep |
10,6C |
R5324 |
T7810 |
T7809 |
punct |
: ,10 |
R5325 |
T7811 |
T7812 |
nsubj |
F,17.2 |
R5326 |
T7812 |
T7809 |
ccomp |
17.2,10 |
R5327 |
T7813 |
T7811 |
punct |
(,F |
R5328 |
T7814 |
T7811 |
nummod |
2,F |
R5329 |
T7815 |
T7811 |
punct |
",",F |
R5330 |
T7816 |
T7811 |
nummod |
41,F |
R5331 |
T7817 |
T7811 |
punct |
),F |
R5332 |
T7818 |
T7812 |
punct |
=,17.2 |
R5333 |
T7819 |
T7809 |
punct |
", ",10 |
R5334 |
T7820 |
T7809 |
nsubj |
p,10 |
R5335 |
T7821 |
T7809 |
punct |
<,10 |
R5336 |
T7822 |
T7823 |
punct |
−,5 |
R5337 |
T7823 |
T7809 |
prep |
5,10 |
R5338 |
T7824 |
T7800 |
punct |
;,6C |
R5339 |
T7825 |
T7826 |
advmod |
post,hoc |
R5340 |
T7826 |
T7827 |
amod |
hoc,Keuls |
R5341 |
T7827 |
T7829 |
dep |
Keuls,3 |
R5342 |
T7828 |
T7827 |
compound |
Newman,Keuls |
R5343 |
T7829 |
T7800 |
dep |
3,6C |
R5344 |
T7830 |
T7829 |
punct |
: ,3 |
R5345 |
T7831 |
T7829 |
nsubj |
p,3 |
R5346 |
T7832 |
T7829 |
punct |
<,3 |
R5347 |
T7833 |
T7829 |
quantmod |
10,3 |
R5348 |
T7834 |
T7829 |
punct |
−,3 |
R5349 |
T7835 |
T7800 |
punct |
),6C |
R5350 |
T7836 |
T7792 |
punct |
", ",improved |
R5351 |
T7837 |
T7838 |
mark |
as,expected |
R5352 |
T7838 |
T7792 |
advcl |
expected,improved |
R5353 |
T7839 |
T7840 |
mark |
if,is |
R5354 |
T7840 |
T7792 |
advcl |
is,improved |
R5355 |
T7841 |
T7842 |
det |
the,phenotype |
R5356 |
T7842 |
T7840 |
nsubj |
phenotype,is |
R5357 |
T7843 |
T7844 |
amod |
enhanced,discrimination |
R5358 |
T7844 |
T7842 |
compound |
discrimination,phenotype |
R5359 |
T7845 |
T7840 |
prep |
due,is |
R5360 |
T7846 |
T7845 |
pcomp |
to,due |
R5361 |
T7847 |
T7848 |
npadvmod |
Ca2,permeable |
R5362 |
T7848 |
T7851 |
amod |
permeable,AMPARs |
R5363 |
T7849 |
T7847 |
punct |
+,Ca2 |
R5364 |
T7850 |
T7848 |
punct |
-,permeable |
R5365 |
T7851 |
T7845 |
pobj |
AMPARs,due |
R5366 |
T7852 |
T7851 |
prep |
in,AMPARs |
R5367 |
T7853 |
T7854 |
det |
the,bulb |
R5368 |
T7854 |
T7852 |
pobj |
bulb,in |
R5369 |
T7855 |
T7854 |
amod |
olfactory,bulb |
R5370 |
T7856 |
T7845 |
cc |
and,due |
R5371 |
T7857 |
T7845 |
conj |
unaffected,due |
R5372 |
T7858 |
T7857 |
prep |
by,unaffected |
R5373 |
T7859 |
T7860 |
compound |
GluR,B |
R5374 |
T7860 |
T7862 |
compound |
B,expression |
R5375 |
T7861 |
T7860 |
punct |
-,B |
R5376 |
T7862 |
T7858 |
pobj |
expression,by |
R5377 |
T7863 |
T7862 |
prep |
in,expression |
R5378 |
T7864 |
T7865 |
amod |
piriform,cortex |
R5379 |
T7865 |
T7863 |
pobj |
cortex,in |
R5380 |
T7866 |
T7865 |
cc |
or,cortex |
R5381 |
T7867 |
T7865 |
conj |
hippocampus,cortex |
R5382 |
T7868 |
T7741 |
punct |
.,was |
R5383 |
T7870 |
T7871 |
advmod |
Hence,rescues |
R5384 |
T7872 |
T7871 |
punct |
", ",rescues |
R5385 |
T7873 |
T7874 |
amod |
transgenic,expression |
R5386 |
T7874 |
T7871 |
nsubj |
expression,rescues |
R5387 |
T7875 |
T7876 |
compound |
GluR,B |
R5388 |
T7876 |
T7874 |
compound |
B,expression |
R5389 |
T7877 |
T7876 |
punct |
-,B |
R5390 |
T7878 |
T7874 |
punct |
", ",expression |
R5391 |
T7879 |
T7880 |
advmod |
specifically,in |
R5392 |
T7880 |
T7874 |
prep |
in,expression |
R5393 |
T7881 |
T7882 |
det |
the,cortex |
R5394 |
T7882 |
T7880 |
pobj |
cortex,in |
R5395 |
T7883 |
T7882 |
amod |
piriform,cortex |
R5396 |
T7884 |
T7882 |
cc |
and,cortex |
R5397 |
T7885 |
T7882 |
conj |
hippocampus,cortex |
R5398 |
T7886 |
T7874 |
prep |
in,expression |
R5399 |
T7887 |
T7888 |
det |
the,background |
R5400 |
T7888 |
T7886 |
pobj |
background,in |
R5401 |
T7890 |
T7888 |
compound |
B,background |
R5402 |
T7891 |
T7890 |
punct |
-,B |
R5403 |
T7892 |
T7888 |
compound |
knockout,background |
R5404 |
T7893 |
T7871 |
punct |
", ",rescues |
R5405 |
T7894 |
T7895 |
det |
the,deficit |
R5406 |
T7895 |
T7871 |
dobj |
deficit,rescues |
R5407 |
T7896 |
T7897 |
compound |
odor,memory |
R5408 |
T7897 |
T7895 |
compound |
memory,deficit |
R5409 |
T7898 |
T7871 |
cc |
but,rescues |
R5410 |
T7899 |
T7871 |
conj |
leaves,rescues |
R5411 |
T7900 |
T7901 |
amod |
enhanced,discrimination |
R5412 |
T7901 |
T7899 |
dobj |
discrimination,leaves |
R5413 |
T7902 |
T7901 |
amod |
olfactory,discrimination |
R5414 |
T7903 |
T7901 |
cc |
and,discrimination |
R5415 |
T7904 |
T7901 |
conj |
learning,discrimination |
R5416 |
T7905 |
T7899 |
oprd |
unaltered,leaves |
R5417 |
T7889 |
T7890 |
compound |
GluR,B |
R5419 |
T7906 |
T7871 |
punct |
.,rescues |
R5421 |
T8327 |
T8328 |
advmod |
Here,present |
R5422 |
T8329 |
T8328 |
nsubj |
we,present |
R5423 |
T8330 |
T8331 |
amod |
mechanistic,dissections |
R5424 |
T8331 |
T8328 |
dobj |
dissections,present |
R5425 |
T8332 |
T8330 |
cc |
and,mechanistic |
R5426 |
T8333 |
T8330 |
conj |
spatial,mechanistic |
R5427 |
T8334 |
T8331 |
prep |
of,dissections |
R5428 |
T8335 |
T8336 |
amod |
olfactory,discrimination |
R5429 |
T8336 |
T8334 |
pobj |
discrimination,of |
R5430 |
T8337 |
T8336 |
punct |
", ",discrimination |
R5431 |
T8338 |
T8336 |
conj |
learning,discrimination |
R5432 |
T8339 |
T8338 |
punct |
", ",learning |
R5433 |
T8340 |
T8338 |
cc |
and,learning |
R5434 |
T8341 |
T8338 |
conj |
memory,learning |
R5435 |
T8342 |
T8328 |
punct |
.,present |
R5436 |
T8344 |
T8345 |
nsubj |
We,employed |
R5437 |
T8346 |
T8347 |
npadvmod |
gene,targeted |
R5438 |
T8347 |
T8349 |
amod |
targeted,mice |
R5439 |
T8348 |
T8347 |
punct |
-,targeted |
R5440 |
T8349 |
T8345 |
dobj |
mice,employed |
R5441 |
T8350 |
T8347 |
cc |
and,targeted |
R5442 |
T8351 |
T8347 |
conj |
transgenic,targeted |
R5443 |
T8352 |
T8349 |
prep |
with,mice |
R5444 |
T8353 |
T8354 |
npadvmod |
region,specific |
R5445 |
T8354 |
T8356 |
amod |
specific,expression |
R5446 |
T8355 |
T8354 |
punct |
-,specific |
R5447 |
T8356 |
T8352 |
pobj |
expression,with |
R5448 |
T8357 |
T8358 |
aux |
to,demonstrate |
R5449 |
T8358 |
T8345 |
advcl |
demonstrate,employed |
R5450 |
T8359 |
T8360 |
mark |
that,enhances |
R5451 |
T8360 |
T8358 |
ccomp |
enhances,demonstrate |
R5452 |
T8361 |
T8362 |
det |
a,change |
R5453 |
T8362 |
T8360 |
nsubj |
change,enhances |
R5454 |
T8363 |
T8362 |
prep |
in,change |
R5455 |
T8364 |
T8365 |
compound |
GluR,B |
R5456 |
T8365 |
T8367 |
npadvmod |
B,mediated |
R5457 |
T8366 |
T8365 |
punct |
-,B |
R5458 |
T8367 |
T8369 |
amod |
mediated,properties |
R5459 |
T8368 |
T8367 |
punct |
-,mediated |
R5460 |
T8369 |
T8363 |
pobj |
properties,in |
R5461 |
T8370 |
T8369 |
prep |
of,properties |
R5462 |
T8371 |
T8372 |
compound |
AMPA,channels |
R5463 |
T8372 |
T8370 |
pobj |
channels,of |
R5464 |
T8373 |
T8372 |
prep |
in,channels |
R5465 |
T8374 |
T8375 |
npadvmod |
αCaMKII,expressing |
R5466 |
T8375 |
T8377 |
amod |
expressing,neurons |
R5467 |
T8376 |
T8375 |
punct |
-,expressing |
R5468 |
T8377 |
T8373 |
pobj |
neurons,in |
R5469 |
T8378 |
T8377 |
prep |
of,neurons |
R5470 |
T8379 |
T8380 |
compound |
mouse,forebrain |
R5471 |
T8380 |
T8378 |
pobj |
forebrain,of |
R5472 |
T8381 |
T8377 |
punct |
", ",neurons |
R5473 |
T8382 |
T8377 |
prep |
including,neurons |
R5474 |
T8383 |
T8384 |
amod |
olfactory,bulb |
R5475 |
T8384 |
T8385 |
nmod |
bulb,cells |
R5476 |
T8385 |
T8382 |
pobj |
cells,including |
R5477 |
T8386 |
T8385 |
amod |
mitral,cells |
R5478 |
T8387 |
T8386 |
cc |
and,mitral |
R5479 |
T8388 |
T8386 |
conj |
granule,mitral |
R5480 |
T8389 |
T8360 |
punct |
", ",enhances |
R5481 |
T8390 |
T8391 |
amod |
olfactory,discrimination |
R5482 |
T8391 |
T8360 |
dobj |
discrimination,enhances |
R5483 |
T8392 |
T8391 |
cc |
and,discrimination |
R5484 |
T8393 |
T8391 |
conj |
learning,discrimination |
R5485 |
T8394 |
T8360 |
cc |
but,enhances |
R5486 |
T8395 |
T8360 |
conj |
impairs,enhances |
R5487 |
T8396 |
T8397 |
amod |
olfactory,memory |
R5488 |
T8397 |
T8395 |
dobj |
memory,impairs |
R5489 |
T8398 |
T8345 |
punct |
.,employed |
R5490 |
T8400 |
T8401 |
det |
These,behaviors |
R5491 |
T8401 |
T8404 |
nsubjpass |
behaviors,assessed |
R5492 |
T8402 |
T8401 |
amod |
pertinent,behaviors |
R5493 |
T8403 |
T8401 |
amod |
olfactory,behaviors |
R5494 |
T8405 |
T8404 |
auxpass |
were,assessed |
R5495 |
T8406 |
T8404 |
prep |
in,assessed |
R5496 |
T8407 |
T8408 |
det |
a,task |
R5497 |
T8408 |
T8406 |
pobj |
task,in |
R5498 |
T8409 |
T8408 |
nmod |
go,task |
R5499 |
T8410 |
T8409 |
punct |
/,go |
R5500 |
T8411 |
T8412 |
det |
no,go |
R5501 |
T8412 |
T8409 |
appos |
go,go |
R5502 |
T8413 |
T8412 |
punct |
-,go |
R5503 |
T8414 |
T8415 |
compound |
operant,conditioning |
R5504 |
T8415 |
T8408 |
compound |
conditioning,task |
R5505 |
T8416 |
T8408 |
punct |
", ",task |
R5506 |
T8417 |
T8418 |
dep |
which,provides |
R5507 |
T8418 |
T8408 |
relcl |
provides,task |
R5508 |
T8419 |
T8420 |
det |
a,tool |
R5509 |
T8420 |
T8418 |
dobj |
tool,provides |
R5510 |
T8421 |
T8420 |
amod |
quantitative,tool |
R5511 |
T8422 |
T8421 |
punct |
", ",quantitative |
R5512 |
T8423 |
T8421 |
conj |
robust,quantitative |
R5513 |
T8424 |
T8423 |
punct |
", ",robust |
R5514 |
T8425 |
T8423 |
cc |
and,robust |
R5515 |
T8426 |
T8423 |
conj |
reproducible,robust |
R5516 |
T8427 |
T8420 |
amod |
behavioral,tool |
R5517 |
T8428 |
T8429 |
punct |
[,3 |
R5518 |
T8429 |
T8404 |
parataxis |
3,assessed |
R5519 |
T8430 |
T8429 |
punct |
],3 |
R5520 |
T8431 |
T8404 |
punct |
.,assessed |
R5521 |
T8433 |
T8434 |
nsubj |
We,observed |
R5522 |
T8435 |
T8434 |
prep |
among,observed |
R5523 |
T8436 |
T8437 |
amod |
individual,mice |
R5524 |
T8437 |
T8435 |
pobj |
mice,among |
R5525 |
T8438 |
T8439 |
det |
a,variability |
R5526 |
T8439 |
T8434 |
dobj |
variability,observed |
R5527 |
T8440 |
T8439 |
amod |
striking,variability |
R5528 |
T8441 |
T8439 |
prep |
in,variability |
R5529 |
T8442 |
T8443 |
amod |
olfactory,memory |
R5530 |
T8443 |
T8444 |
compound |
memory,performance |
R5531 |
T8444 |
T8441 |
pobj |
performance,in |
R5532 |
T8445 |
T8441 |
cc |
but,in |
R5533 |
T8446 |
T8445 |
neg |
not,but |
R5534 |
T8447 |
T8441 |
conj |
in,in |
R5535 |
T8448 |
T8449 |
compound |
odor,discrimination |
R5536 |
T8449 |
T8447 |
pobj |
discrimination,in |
R5537 |
T8450 |
T8434 |
punct |
.,observed |
R5538 |
T8452 |
T8453 |
det |
This,variability |
R5539 |
T8453 |
T8454 |
nsubjpass |
variability,traced |
R5540 |
T8455 |
T8454 |
aux |
could,traced |
R5541 |
T8456 |
T8454 |
auxpass |
be,traced |
R5542 |
T8457 |
T8454 |
prep |
to,traced |
R5543 |
T8458 |
T8459 |
amod |
epigenetic,variability |
R5544 |
T8459 |
T8457 |
pobj |
variability,to |
R5545 |
T8460 |
T8459 |
prep |
in,variability |
R5546 |
T8461 |
T8462 |
det |
the,expression |
R5547 |
T8462 |
T8460 |
pobj |
expression,in |
R5548 |
T8463 |
T8462 |
amod |
transgenic,expression |
R5549 |
T8464 |
T8462 |
prep |
of,expression |
R5550 |
T8465 |
T8466 |
compound |
Cre,recombinase |
R5551 |
T8466 |
T8464 |
pobj |
recombinase,of |
R5552 |
T8467 |
T8466 |
punct |
-,recombinase |
R5553 |
T8468 |
T8466 |
punct |
", ",recombinase |
R5554 |
T8469 |
T8470 |
dep |
which,mediated |
R5555 |
T8470 |
T8466 |
relcl |
mediated,recombinase |
R5556 |
T8471 |
T8470 |
dobj |
recombination,mediated |
R5557 |
T8472 |
T8470 |
prep |
within,mediated |
R5558 |
T8473 |
T8474 |
npadvmod |
loxP,flanked |
R5559 |
T8474 |
T8476 |
amod |
flanked,segments |
R5560 |
T8475 |
T8474 |
punct |
-,flanked |
R5561 |
T8476 |
T8472 |
pobj |
segments,within |
R5562 |
T8477 |
T8476 |
prep |
of,segments |
R5563 |
T8478 |
T8479 |
npadvmod |
gene,targeted |
R5564 |
T8479 |
T8481 |
amod |
targeted,alleles |
R5565 |
T8480 |
T8479 |
punct |
-,targeted |
R5566 |
T8481 |
T8477 |
pobj |
alleles,of |
R5567 |
T8482 |
T8470 |
prep |
for,mediated |
R5568 |
T8483 |
T8484 |
det |
the,subunit |
R5569 |
T8484 |
T8482 |
pobj |
subunit,for |
R5570 |
T8485 |
T8484 |
amod |
dominant,subunit |
R5571 |
T8486 |
T8484 |
compound |
AMPAR,subunit |
R5572 |
T8487 |
T8488 |
compound |
GluR,B |
R5573 |
T8488 |
T8484 |
appos |
B,subunit |
R5574 |
T8489 |
T8488 |
punct |
-,B |
R5575 |
T8490 |
T8470 |
punct |
", ",mediated |
R5576 |
T8491 |
T8470 |
cc |
and,mediated |
R5577 |
T8492 |
T8493 |
advmod |
hence,operated |
R5578 |
T8493 |
T8470 |
conj |
operated,mediated |
R5579 |
T8494 |
T8495 |
det |
the,switch |
R5580 |
T8495 |
T8493 |
dobj |
switch,operated |
R5581 |
T8496 |
T8495 |
prep |
in,switch |
R5582 |
T8497 |
T8498 |
compound |
AMPAR,properties |
R5583 |
T8498 |
T8496 |
pobj |
properties,in |
R5584 |
T8499 |
T8495 |
prep |
toward,switch |
R5585 |
T8500 |
T8501 |
compound |
GluR,B |
R5586 |
T8501 |
T8503 |
compound |
B,ablation |
R5587 |
T8502 |
T8501 |
punct |
-,B |
R5588 |
T8503 |
T8499 |
pobj |
ablation,toward |
R5589 |
T8504 |
T8503 |
cc |
and,ablation |
R5590 |
T8505 |
T8506 |
amod |
increased,permeability |
R5591 |
T8506 |
T8503 |
conj |
permeability,ablation |
R5592 |
T8507 |
T8506 |
nmod |
Ca2,permeability |
R5593 |
T8508 |
T8507 |
punct |
+,Ca2 |
R5594 |
T8509 |
T8454 |
punct |
.,traced |
R5595 |
T8511 |
T8512 |
prep |
In,appeared |
R5596 |
T8513 |
T8511 |
pobj |
contrast,In |
R5597 |
T8514 |
T8513 |
prep |
to,contrast |
R5598 |
T8515 |
T8516 |
amod |
variable,memory |
R5599 |
T8516 |
T8514 |
pobj |
memory,to |
R5600 |
T8517 |
T8512 |
punct |
", ",appeared |
R5601 |
T8518 |
T8519 |
amod |
olfactory,discrimination |
R5602 |
T8519 |
T8520 |
nmod |
discrimination,performances |
R5603 |
T8520 |
T8512 |
nsubj |
performances,appeared |
R5604 |
T8521 |
T8519 |
cc |
and,discrimination |
R5605 |
T8522 |
T8519 |
conj |
learning,discrimination |
R5606 |
T8523 |
T8512 |
advmod |
already,appeared |
R5607 |
T8524 |
T8512 |
oprd |
saturated,appeared |
R5608 |
T8525 |
T8524 |
prep |
by,saturated |
R5609 |
T8526 |
T8527 |
advmod |
even,extents |
R5610 |
T8527 |
T8525 |
pobj |
extents,by |
R5611 |
T8528 |
T8527 |
amod |
moderate,extents |
R5612 |
T8529 |
T8527 |
prep |
of,extents |
R5613 |
T8530 |
T8531 |
compound |
Cre,expression |
R5614 |
T8531 |
T8529 |
pobj |
expression,of |
R5615 |
T8532 |
T8527 |
punct |
", ",extents |
R5616 |
T8533 |
T8527 |
cc |
and,extents |
R5617 |
T8534 |
T8535 |
advmod |
hence,changes |
R5618 |
T8535 |
T8527 |
conj |
changes,extents |
R5619 |
T8536 |
T8535 |
amod |
moderate,changes |
R5620 |
T8537 |
T8535 |
prep |
in,changes |
R5621 |
T8538 |
T8539 |
compound |
AMPAR,properties |
R5622 |
T8539 |
T8537 |
pobj |
properties,in |
R5623 |
T8540 |
T8512 |
punct |
.,appeared |
R5624 |
T8542 |
T8543 |
det |
The,re-introduction |
R5625 |
T8543 |
T8548 |
nsubj |
re-introduction,reversed |
R5626 |
T8544 |
T8543 |
amod |
subsequent,re-introduction |
R5627 |
T8545 |
T8546 |
npadvmod |
transgene,driven |
R5628 |
T8546 |
T8543 |
amod |
driven,re-introduction |
R5629 |
T8547 |
T8546 |
punct |
-,driven |
R5630 |
T8549 |
T8543 |
prep |
of,re-introduction |
R5631 |
T8550 |
T8551 |
compound |
GluR,B |
R5632 |
T8551 |
T8549 |
pobj |
B,of |
R5633 |
T8552 |
T8551 |
punct |
-,B |
R5634 |
T8553 |
T8543 |
punct |
", ",re-introduction |
R5635 |
T8554 |
T8555 |
advmod |
specifically,in |
R5636 |
T8555 |
T8543 |
prep |
in,re-introduction |
R5637 |
T8556 |
T8557 |
amod |
piriform,cortex |
R5638 |
T8557 |
T8555 |
pobj |
cortex,in |
R5639 |
T8558 |
T8557 |
cc |
and,cortex |
R5640 |
T8559 |
T8557 |
conj |
hippocampus,cortex |
R5641 |
T8560 |
T8548 |
punct |
", ",reversed |
R5642 |
T8561 |
T8562 |
det |
the,loss |
R5643 |
T8562 |
T8548 |
dobj |
loss,reversed |
R5644 |
T8563 |
T8564 |
npadvmod |
Cre,induced |
R5645 |
T8564 |
T8562 |
amod |
induced,loss |
R5646 |
T8565 |
T8564 |
punct |
-,induced |
R5647 |
T8566 |
T8562 |
prep |
of,loss |
R5648 |
T8567 |
T8568 |
compound |
GluR,B |
R5649 |
T8568 |
T8566 |
pobj |
B,of |
R5650 |
T8569 |
T8568 |
punct |
-,B |
R5651 |
T8570 |
T8548 |
cc |
and,reversed |
R5652 |
T8571 |
T8572 |
advmod |
partially,rescued |
R5653 |
T8572 |
T8548 |
conj |
rescued,reversed |
R5654 |
T8573 |
T8574 |
det |
the,deficit |
R5655 |
T8574 |
T8572 |
dobj |
deficit,rescued |
R5656 |
T8575 |
T8576 |
compound |
odor,memory |
R5657 |
T8576 |
T8574 |
compound |
memory,deficit |
R5658 |
T8577 |
T8548 |
punct |
", ",reversed |
R5659 |
T8578 |
T8548 |
cc |
but,reversed |
R5660 |
T8579 |
T8548 |
conj |
left,reversed |
R5661 |
T8580 |
T8579 |
oprd |
unaltered,left |
R5662 |
T8581 |
T8582 |
det |
the,discrimination |
R5663 |
T8582 |
T8579 |
dobj |
discrimination,left |
R5664 |
T8583 |
T8582 |
amod |
enhanced,discrimination |
R5665 |
T8584 |
T8582 |
amod |
olfactory,discrimination |
R5666 |
T8585 |
T8548 |
punct |
.,reversed |
R5667 |
T8587 |
T8588 |
prep |
In,conclude |
R5668 |
T8589 |
T8590 |
det |
a,nutshell |
R5669 |
T8590 |
T8587 |
pobj |
nutshell,In |
R5670 |
T8591 |
T8588 |
punct |
", ",conclude |
R5671 |
T8592 |
T8588 |
nsubj |
we,conclude |
R5672 |
T8593 |
T8594 |
mark |
that,enhanced |
R5673 |
T8594 |
T8588 |
ccomp |
enhanced,conclude |
R5674 |
T8595 |
T8596 |
amod |
olfactory,discrimination |
R5675 |
T8596 |
T8594 |
nsubjpass |
discrimination,enhanced |
R5676 |
T8597 |
T8594 |
auxpass |
is,enhanced |
R5677 |
T8598 |
T8594 |
agent |
by,enhanced |
R5678 |
T8599 |
T8600 |
det |
an,increase |
R5679 |
T8600 |
T8598 |
pobj |
increase,by |
R5680 |
T8601 |
T8600 |
prep |
in,increase |
R5681 |
T8602 |
T8603 |
npadvmod |
AMPAR,mediated |
R5682 |
T8603 |
T8605 |
amod |
mediated,permeability |
R5683 |
T8604 |
T8603 |
punct |
-,mediated |
R5684 |
T8605 |
T8601 |
pobj |
permeability,in |
R5685 |
T8606 |
T8605 |
nmod |
Ca2,permeability |
R5686 |
T8607 |
T8606 |
punct |
+,Ca2 |
R5687 |
T8608 |
T8594 |
prep |
within,enhanced |
R5688 |
T8609 |
T8610 |
det |
the,bulb |
R5689 |
T8610 |
T8608 |
pobj |
bulb,within |
R5690 |
T8611 |
T8610 |
amod |
olfactory,bulb |
R5691 |
T8612 |
T8594 |
punct |
", ",enhanced |
R5692 |
T8613 |
T8614 |
mark |
whereas,becomes |
R5693 |
T8614 |
T8594 |
advcl |
becomes,enhanced |
R5694 |
T8615 |
T8616 |
amod |
olfactory,memory |
R5695 |
T8616 |
T8614 |
nsubj |
memory,becomes |
R5696 |
T8617 |
T8614 |
acomp |
impaired,becomes |
R5697 |
T8618 |
T8614 |
prep |
upon,becomes |
R5698 |
T8619 |
T8620 |
advmod |
genetically,induced |
R5699 |
T8620 |
T8621 |
amod |
induced,ablation |
R5700 |
T8621 |
T8618 |
pobj |
ablation,upon |
R5701 |
T8622 |
T8623 |
compound |
GluR,B |
R5702 |
T8623 |
T8621 |
compound |
B,ablation |
R5703 |
T8624 |
T8623 |
punct |
-,B |
R5704 |
T8625 |
T8614 |
prep |
in,becomes |
R5705 |
T8626 |
T8627 |
amod |
higher,centers |
R5706 |
T8627 |
T8625 |
pobj |
centers,in |
R5707 |
T8628 |
T8627 |
compound |
brain,centers |
R5708 |
T8629 |
T8625 |
punct |
", ",in |
R5709 |
T8630 |
T8631 |
advmod |
specifically,in |
R5710 |
T8631 |
T8625 |
prep |
in,in |
R5711 |
T8632 |
T8633 |
amod |
piriform,cortex |
R5712 |
T8633 |
T8631 |
pobj |
cortex,in |
R5713 |
T8634 |
T8588 |
punct |
.,conclude |
R5724 |
T8822 |
T8823 |
amod |
Olfactory,Discrimination |
R5725 |
T8823 |
T8824 |
nsubjpass |
Discrimination,Increased |
R5726 |
T8825 |
T8824 |
auxpass |
Is,Increased |
R5727 |
T8826 |
T8824 |
prep |
in,Increased |
R5728 |
T8827 |
T8826 |
pobj |
Mice,in |
R5729 |
T8828 |
T8827 |
prep |
with,Mice |
R5730 |
T8829 |
T8830 |
npadvmod |
Forebrain,Specific |
R5731 |
T8830 |
T8832 |
amod |
Specific,Ablation |
R5732 |
T8831 |
T8830 |
punct |
-,Specific |
R5733 |
T8832 |
T8828 |
pobj |
Ablation,with |
R5734 |
T8833 |
T8834 |
compound |
GluR,B |
R5735 |
T8834 |
T8832 |
compound |
B,Ablation |
R5736 |
T8835 |
T8834 |
punct |
-,B |
R5737 |
T8836 |
T8832 |
cc |
or,Ablation |
R5738 |
T8837 |
T8838 |
nmod |
GluR,Q |
R5739 |
T8838 |
T8842 |
nmod |
Q,Expression |
R5740 |
T8839 |
T8838 |
punct |
-,Q |
R5741 |
T8840 |
T8838 |
nmod |
B,Q |
R5742 |
T8841 |
T8838 |
punct |
(,Q |
R5743 |
T8842 |
T8832 |
conj |
Expression,Ablation |
R5744 |
T8843 |
T8838 |
punct |
),Q |
R5745 |
T8845 |
T8846 |
preconj |
Both,expression |
R5746 |
T8846 |
T8856 |
nsubj |
expression,led |
R5747 |
T8847 |
T8848 |
npadvmod |
forebrain,specific |
R5748 |
T8848 |
T8846 |
amod |
specific,expression |
R5749 |
T8849 |
T8848 |
punct |
-,specific |
R5750 |
T8850 |
T8851 |
nmod |
GluR,Q |
R5751 |
T8851 |
T8846 |
nmod |
Q,expression |
R5752 |
T8852 |
T8851 |
punct |
-,Q |
R5753 |
T8853 |
T8851 |
nmod |
B,Q |
R5754 |
T8854 |
T8851 |
punct |
(,Q |
R5755 |
T8855 |
T8851 |
punct |
),Q |
R5756 |
T8857 |
T8846 |
cc |
and,expression |
R5757 |
T8858 |
T8859 |
compound |
GluR,B |
R5758 |
T8859 |
T8861 |
compound |
B,depletion |
R5759 |
T8860 |
T8859 |
punct |
-,B |
R5760 |
T8861 |
T8846 |
conj |
depletion,expression |
R5761 |
T8862 |
T8856 |
prep |
to,led |
R5762 |
T8863 |
T8864 |
amod |
increased,capabilities |
R5763 |
T8864 |
T8862 |
pobj |
capabilities,to |
R5764 |
T8865 |
T8866 |
amod |
olfactory,learning |
R5765 |
T8866 |
T8864 |
nmod |
learning,capabilities |
R5766 |
T8867 |
T8866 |
cc |
and,learning |
R5767 |
T8868 |
T8866 |
conj |
discrimination,learning |
R5768 |
T8869 |
T8856 |
punct |
.,led |
R5769 |
T8871 |
T8872 |
nsubj |
This,was |
R5770 |
T8873 |
T8874 |
advmod |
rather,pronounced |
R5771 |
T8874 |
T8872 |
acomp |
pronounced,was |
R5772 |
T8875 |
T8872 |
prep |
for,was |
R5773 |
T8876 |
T8877 |
nmod |
GluR,Q |
R5774 |
T8877 |
T8881 |
npadvmod |
Q,expressing |
R5775 |
T8878 |
T8877 |
punct |
-,Q |
R5776 |
T8879 |
T8877 |
nmod |
B,Q |
R5777 |
T8880 |
T8877 |
punct |
(,Q |
R5778 |
T8881 |
T8884 |
amod |
expressing,mice |
R5779 |
T8882 |
T8877 |
punct |
),Q |
R5780 |
T8883 |
T8881 |
punct |
-,expressing |
R5781 |
T8884 |
T8875 |
pobj |
mice,for |
R5782 |
T8885 |
T8872 |
punct |
", ",was |
R5783 |
T8886 |
T8872 |
advcl |
consistent,was |
R5784 |
T8887 |
T8886 |
prep |
with,consistent |
R5785 |
T8888 |
T8889 |
det |
the,consequences |
R5786 |
T8889 |
T8887 |
pobj |
consequences,with |
R5787 |
T8890 |
T8891 |
amod |
overall,stronger |
R5788 |
T8891 |
T8889 |
amod |
stronger,consequences |
R5789 |
T8892 |
T8889 |
amod |
phenotypic,consequences |
R5790 |
T8893 |
T8889 |
prep |
in,consequences |
R5791 |
T8894 |
T8893 |
pobj |
comparison,in |
R5792 |
T8895 |
T8894 |
prep |
to,comparison |
R5793 |
T8896 |
T8897 |
compound |
GluR,B |
R5794 |
T8897 |
T8899 |
compound |
B,depletion |
R5795 |
T8898 |
T8897 |
punct |
-,B |
R5796 |
T8899 |
T8895 |
pobj |
depletion,to |
R5797 |
T8900 |
T8886 |
punct |
", ",consistent |
R5798 |
T8901 |
T8902 |
preconj |
both,selective |
R5799 |
T8902 |
T8886 |
advcl |
selective,consistent |
R5800 |
T8903 |
T8902 |
advmod |
when,selective |
R5801 |
T8904 |
T8902 |
npadvmod |
forebrain,selective |
R5802 |
T8905 |
T8902 |
punct |
-,selective |
R5803 |
T8906 |
T8907 |
punct |
(,58 |
R5804 |
T8907 |
T8902 |
parataxis |
58,selective |
R5805 |
T8908 |
T8907 |
punct |
[,58 |
R5806 |
T8909 |
T8907 |
punct |
],58 |
R5807 |
T8910 |
T8907 |
punct |
", ",58 |
R5808 |
T8911 |
T8907 |
cc |
and,58 |
R5809 |
T8912 |
T8913 |
det |
this,study |
R5810 |
T8913 |
T8907 |
conj |
study,58 |
R5811 |
T8914 |
T8907 |
punct |
),58 |
R5812 |
T8915 |
T8902 |
cc |
or,selective |
R5813 |
T8916 |
T8902 |
conj |
global,selective |
R5814 |
T8917 |
T8918 |
punct |
[,60 |
R5815 |
T8918 |
T8916 |
parataxis |
60,global |
R5816 |
T8919 |
T8918 |
nummod |
53,60 |
R5817 |
T8920 |
T8918 |
punct |
",",60 |
R5818 |
T8921 |
T8918 |
punct |
],60 |
R5819 |
T8922 |
T8872 |
punct |
.,was |
R5820 |
T8924 |
T8925 |
det |
A,analysis |
R5821 |
T8925 |
T8927 |
nsubj |
analysis,were |
R5822 |
T8926 |
T8925 |
amod |
detailed,analysis |
R5823 |
T8928 |
T8925 |
prep |
of,analysis |
R5824 |
T8929 |
T8930 |
det |
the,pattern |
R5825 |
T8930 |
T8928 |
pobj |
pattern,of |
R5826 |
T8931 |
T8930 |
compound |
sampling,pattern |
R5827 |
T8932 |
T8933 |
punct |
[,3 |
R5828 |
T8933 |
T8925 |
parataxis |
3,analysis |
R5829 |
T8934 |
T8933 |
punct |
],3 |
R5830 |
T8935 |
T8925 |
punct |
", ",analysis |
R5831 |
T8936 |
T8925 |
cc |
and,analysis |
R5832 |
T8937 |
T8938 |
prep |
in,analysis |
R5833 |
T8938 |
T8925 |
conj |
analysis,analysis |
R5834 |
T8939 |
T8937 |
amod |
particular,in |
R5835 |
T8940 |
T8938 |
det |
the,analysis |
R5836 |
T8941 |
T8938 |
prep |
of,analysis |
R5837 |
T8942 |
T8943 |
compound |
discrimination,tasks |
R5838 |
T8943 |
T8941 |
pobj |
tasks,of |
R5839 |
T8944 |
T8945 |
dep |
that,involved |
R5840 |
T8945 |
T8943 |
relcl |
involved,tasks |
R5841 |
T8946 |
T8945 |
punct |
“,involved |
R5842 |
T8947 |
T8948 |
amod |
simple,pairs |
R5843 |
T8948 |
T8945 |
dobj |
pairs,involved |
R5844 |
T8949 |
T8948 |
punct |
”,pairs |
R5845 |
T8950 |
T8948 |
amod |
dissimilar,pairs |
R5846 |
T8951 |
T8948 |
amod |
monomolecular,pairs |
R5847 |
T8952 |
T8948 |
compound |
odor,pairs |
R5848 |
T8953 |
T8948 |
cc |
and,pairs |
R5849 |
T8954 |
T8955 |
punct |
“,mixtures |
R5850 |
T8955 |
T8948 |
conj |
mixtures,pairs |
R5851 |
T8956 |
T8955 |
amod |
difficult,mixtures |
R5852 |
T8957 |
T8955 |
punct |
”,mixtures |
R5853 |
T8958 |
T8955 |
amod |
binary,mixtures |
R5854 |
T8959 |
T8927 |
punct |
", ",were |
R5855 |
T8960 |
T8927 |
acomp |
necessary,were |
R5856 |
T8961 |
T8962 |
aux |
to,capture |
R5857 |
T8962 |
T8927 |
advcl |
capture,were |
R5858 |
T8963 |
T8962 |
advmod |
fully,capture |
R5859 |
T8964 |
T8965 |
det |
the,characteristics |
R5860 |
T8965 |
T8962 |
dobj |
characteristics,capture |
R5861 |
T8966 |
T8965 |
prep |
of,characteristics |
R5862 |
T8967 |
T8968 |
det |
the,phenotype |
R5863 |
T8968 |
T8966 |
pobj |
phenotype,of |
R5864 |
T8969 |
T8970 |
amod |
olfactory,discrimination |
R5865 |
T8970 |
T8968 |
compound |
discrimination,phenotype |
R5866 |
T8971 |
T8965 |
prep |
for,characteristics |
R5867 |
T8972 |
T8973 |
npadvmod |
forebrain,specific |
R5868 |
T8973 |
T8975 |
amod |
specific,mice |
R5869 |
T8974 |
T8973 |
punct |
-,specific |
R5870 |
T8975 |
T8971 |
pobj |
mice,for |
R5871 |
T8976 |
T8977 |
compound |
GluR,B |
R5872 |
T8977 |
T8979 |
npadvmod |
B,depleted |
R5873 |
T8978 |
T8977 |
punct |
-,B |
R5874 |
T8979 |
T8975 |
amod |
depleted,mice |
R5875 |
T8980 |
T8979 |
punct |
-,depleted |
R5876 |
T8981 |
T8927 |
punct |
.,were |
R5877 |
T8983 |
T8984 |
prep |
For,were |
R5878 |
T8985 |
T8986 |
advmod |
closely,related |
R5879 |
T8986 |
T8987 |
amod |
related,mixtures |
R5880 |
T8987 |
T8983 |
pobj |
mixtures,For |
R5881 |
T8988 |
T8987 |
amod |
binary,mixtures |
R5882 |
T8989 |
T8984 |
punct |
", ",were |
R5883 |
T8990 |
T8991 |
compound |
discrimination,improvements |
R5884 |
T8991 |
T8984 |
nsubj |
improvements,were |
R5885 |
T8992 |
T8984 |
acomp |
largest,were |
R5886 |
T8993 |
T8984 |
punct |
", ",were |
R5887 |
T8994 |
T8984 |
advcl |
consistent,were |
R5888 |
T8995 |
T8994 |
prep |
with,consistent |
R5889 |
T8996 |
T8997 |
det |
a,alteration |
R5890 |
T8997 |
T8995 |
pobj |
alteration,with |
R5891 |
T8998 |
T8997 |
amod |
specific,alteration |
R5892 |
T8999 |
T8997 |
prep |
in,alteration |
R5893 |
T9000 |
T9001 |
compound |
odor,discrimination |
R5894 |
T9001 |
T8999 |
pobj |
discrimination,in |
R5895 |
T9002 |
T8997 |
punct |
", ",alteration |
R5896 |
T9003 |
T9004 |
advmod |
rather,than |
R5897 |
T9004 |
T8997 |
cc |
than,alteration |
R5898 |
T9005 |
T9006 |
det |
a,enhancement |
R5899 |
T9006 |
T8997 |
conj |
enhancement,alteration |
R5900 |
T9007 |
T9006 |
amod |
general,enhancement |
R5901 |
T9008 |
T9006 |
prep |
of,enhancement |
R5902 |
T9009 |
T9010 |
compound |
learning,capabilities |
R5903 |
T9010 |
T9008 |
pobj |
capabilities,of |
R5904 |
T9011 |
T8984 |
punct |
.,were |
R5905 |
T9013 |
T9014 |
nsubjpass |
This,supported |
R5906 |
T9015 |
T9014 |
auxpass |
is,supported |
R5907 |
T9016 |
T9014 |
advmod |
further,supported |
R5908 |
T9017 |
T9014 |
agent |
by,supported |
R5909 |
T9018 |
T9019 |
det |
the,notion |
R5910 |
T9019 |
T9017 |
pobj |
notion,by |
R5911 |
T9020 |
T9021 |
mark |
that,observed |
R5912 |
T9021 |
T9019 |
acl |
observed,notion |
R5913 |
T9022 |
T9023 |
det |
no,improvement |
R5914 |
T9023 |
T9021 |
nsubjpass |
improvement,observed |
R5915 |
T9024 |
T9023 |
amod |
general,improvement |
R5916 |
T9025 |
T9021 |
auxpass |
was,observed |
R5917 |
T9026 |
T9021 |
prep |
in,observed |
R5918 |
T9027 |
T9028 |
amod |
other,tasks |
R5919 |
T9028 |
T9026 |
pobj |
tasks,in |
R5920 |
T9029 |
T9028 |
amod |
nonolfactory,tasks |
R5921 |
T9030 |
T9028 |
amod |
behavioral,tasks |
R5922 |
T9031 |
T9028 |
punct |
", ",tasks |
R5923 |
T9032 |
T9033 |
advmod |
e.g.,tasks |
R5924 |
T9033 |
T9028 |
appos |
tasks,tasks |
R5925 |
T9034 |
T9033 |
punct |
", ",tasks |
R5926 |
T9035 |
T9036 |
npadvmod |
hippocampus,dependent |
R5927 |
T9036 |
T9033 |
amod |
dependent,tasks |
R5928 |
T9037 |
T9036 |
punct |
-,dependent |
R5929 |
T9038 |
T9039 |
amod |
spatial,learning |
R5930 |
T9039 |
T9033 |
compound |
learning,tasks |
R5931 |
T9040 |
T9041 |
amod |
such,as |
R5932 |
T9041 |
T9033 |
prep |
as,tasks |
R5933 |
T9042 |
T9043 |
nmod |
matching,tasks |
R5934 |
T9043 |
T9041 |
pobj |
tasks,as |
R5935 |
T9044 |
T9042 |
punct |
-,matching |
R5936 |
T9045 |
T9042 |
prep |
to,matching |
R5937 |
T9046 |
T9045 |
punct |
-,to |
R5938 |
T9047 |
T9045 |
pobj |
place,to |
R5939 |
T9048 |
T9049 |
amod |
spatial,reference |
R5940 |
T9049 |
T9043 |
compound |
reference,tasks |
R5941 |
T9050 |
T9043 |
compound |
memory,tasks |
R5942 |
T9051 |
T9052 |
punct |
(,S2 |
R5943 |
T9052 |
T9014 |
parataxis |
S2,supported |
R5944 |
T9053 |
T9052 |
compound |
Figure,S2 |
R5945 |
T9054 |
T9052 |
punct |
),S2 |
R5946 |
T9055 |
T9014 |
punct |
.,supported |
R5947 |
T9057 |
T9058 |
mark |
As,observed |
R5948 |
T9058 |
T9065 |
advcl |
observed,was |
R5949 |
T9059 |
T9060 |
det |
no,expression |
R5950 |
T9060 |
T9058 |
nsubjpass |
expression,observed |
R5951 |
T9061 |
T9060 |
compound |
Cre,expression |
R5952 |
T9062 |
T9060 |
cc |
and,expression |
R5953 |
T9063 |
T9060 |
conj |
activity,expression |
R5954 |
T9064 |
T9058 |
auxpass |
was,observed |
R5955 |
T9066 |
T9058 |
prep |
in,observed |
R5956 |
T9067 |
T9068 |
det |
the,neurons |
R5957 |
T9068 |
T9066 |
pobj |
neurons,in |
R5958 |
T9069 |
T9068 |
amod |
main,neurons |
R5959 |
T9070 |
T9068 |
amod |
olfactory,neurons |
R5960 |
T9071 |
T9068 |
amod |
sensory,neurons |
R5961 |
T9072 |
T9058 |
prep |
at,observed |
R5962 |
T9073 |
T9074 |
det |
any,stage |
R5963 |
T9074 |
T9072 |
pobj |
stage,at |
R5964 |
T9075 |
T9074 |
amod |
developmental,stage |
R5965 |
T9076 |
T9077 |
punct |
(,S4 |
R5966 |
T9077 |
T9058 |
parataxis |
S4,observed |
R5967 |
T9078 |
T9077 |
compound |
Figure,S4 |
R5968 |
T9079 |
T9077 |
cc |
and,S4 |
R5969 |
T9080 |
T9081 |
amod |
unpublished,data |
R5970 |
T9081 |
T9077 |
conj |
data,S4 |
R5971 |
T9082 |
T9077 |
punct |
),S4 |
R5972 |
T9083 |
T9065 |
punct |
", ",was |
R5973 |
T9084 |
T9085 |
amod |
olfactory,function |
R5974 |
T9085 |
T9065 |
nsubj |
function,was |
R5975 |
T9086 |
T9085 |
amod |
epithelial,function |
R5976 |
T9087 |
T9065 |
acomp |
unaltered,was |
R5977 |
T9088 |
T9087 |
prep |
by,unaltered |
R5978 |
T9089 |
T9090 |
det |
the,modification |
R5979 |
T9090 |
T9088 |
pobj |
modification,by |
R5980 |
T9091 |
T9090 |
amod |
genetic,modification |
R5981 |
T9092 |
T9065 |
punct |
.,was |
R5982 |
T9094 |
T9095 |
det |
The,organ |
R5983 |
T9095 |
T9097 |
nsubj |
organ,showed |
R5984 |
T9096 |
T9095 |
amod |
vomeronasal,organ |
R5985 |
T9098 |
T9099 |
advmod |
very,weak |
R5986 |
T9099 |
T9100 |
amod |
weak,expression |
R5987 |
T9100 |
T9097 |
dobj |
expression,showed |
R5988 |
T9101 |
T9100 |
compound |
Cre,expression |
R5989 |
T9102 |
T9103 |
punct |
(,data |
R5990 |
T9103 |
T9097 |
meta |
data,showed |
R5991 |
T9104 |
T9103 |
amod |
unpublished,data |
R5992 |
T9105 |
T9103 |
punct |
),data |
R5993 |
T9106 |
T9097 |
punct |
", ",showed |
R5994 |
T9107 |
T9097 |
cc |
but,showed |
R5995 |
T9108 |
T9109 |
det |
a,role |
R5996 |
T9109 |
T9110 |
nsubj |
role,is |
R5997 |
T9110 |
T9097 |
conj |
is,showed |
R5998 |
T9111 |
T9109 |
prep |
of,role |
R5999 |
T9112 |
T9113 |
det |
this,structure |
R6000 |
T9113 |
T9111 |
pobj |
structure,of |
R6001 |
T9114 |
T9109 |
prep |
concerning,role |
R6002 |
T9115 |
T9114 |
pobj |
performance,concerning |
R6003 |
T9116 |
T9115 |
prep |
in,performance |
R6004 |
T9117 |
T9118 |
det |
the,task |
R6005 |
T9118 |
T9116 |
pobj |
task,in |
R6006 |
T9119 |
T9120 |
amod |
olfactory,discrimination |
R6007 |
T9120 |
T9118 |
compound |
discrimination,task |
R6008 |
T9121 |
T9110 |
acomp |
unlikely,is |
R6009 |
T9122 |
T9123 |
punct |
(,see |
R6010 |
T9123 |
T9110 |
parataxis |
see,is |
R6011 |
T9124 |
T9123 |
prep |
for,see |
R6012 |
T9125 |
T9124 |
pobj |
review,for |
R6013 |
T9126 |
T9123 |
punct |
", ",see |
R6014 |
T9127 |
T9123 |
punct |
[,see |
R6015 |
T9128 |
T9123 |
dobj |
63,see |
R6016 |
T9129 |
T9123 |
punct |
],see |
R6017 |
T9130 |
T9123 |
punct |
),see |
R6018 |
T9131 |
T9110 |
punct |
.,is |
R6019 |
T9133 |
T9134 |
det |
The,phenotype |
R6020 |
T9134 |
T9136 |
nsubj |
phenotype,is |
R6021 |
T9135 |
T9134 |
amod |
behavioral,phenotype |
R6022 |
T9137 |
T9136 |
advmod |
thus,is |
R6023 |
T9138 |
T9136 |
acomp |
likely,is |
R6024 |
T9139 |
T9140 |
aux |
to,associated |
R6025 |
T9140 |
T9138 |
xcomp |
associated,likely |
R6026 |
T9141 |
T9140 |
auxpass |
be,associated |
R6027 |
T9142 |
T9140 |
prep |
with,associated |
R6028 |
T9143 |
T9144 |
det |
the,processing |
R6029 |
T9144 |
T9142 |
pobj |
processing,with |
R6030 |
T9145 |
T9144 |
prep |
of,processing |
R6031 |
T9146 |
T9147 |
amod |
olfactory,information |
R6032 |
T9147 |
T9145 |
pobj |
information,of |
R6033 |
T9148 |
T9149 |
advmod |
rather,than |
R6034 |
T9149 |
T9144 |
cc |
than,processing |
R6035 |
T9150 |
T9151 |
det |
the,detection |
R6036 |
T9151 |
T9144 |
conj |
detection,processing |
R6037 |
T9152 |
T9151 |
prep |
of,detection |
R6038 |
T9153 |
T9152 |
pobj |
odors,of |
R6039 |
T9154 |
T9136 |
punct |
.,is |
R6040 |
T9156 |
T9157 |
advmod |
Furthermore,supported |
R6041 |
T9158 |
T9157 |
punct |
", ",supported |
R6042 |
T9159 |
T9160 |
amod |
increased,performance |
R6043 |
T9160 |
T9157 |
nsubj |
performance,supported |
R6044 |
T9161 |
T9162 |
advmod |
even,after |
R6045 |
T9162 |
T9160 |
prep |
after,performance |
R6046 |
T9163 |
T9164 |
amod |
long,stretches |
R6047 |
T9164 |
T9162 |
pobj |
stretches,after |
R6048 |
T9165 |
T9164 |
prep |
of,stretches |
R6049 |
T9166 |
T9165 |
pobj |
training,of |
R6050 |
T9167 |
T9160 |
cc |
and,performance |
R6051 |
T9168 |
T9160 |
punct |
", ",performance |
R6052 |
T9169 |
T9170 |
prep |
in,differences |
R6053 |
T9170 |
T9160 |
conj |
differences,performance |
R6054 |
T9171 |
T9169 |
amod |
particular,in |
R6055 |
T9172 |
T9170 |
punct |
", ",differences |
R6056 |
T9173 |
T9170 |
amod |
increased,differences |
R6057 |
T9174 |
T9175 |
compound |
sampling,pattern |
R6058 |
T9175 |
T9170 |
compound |
pattern,differences |
R6059 |
T9176 |
T9177 |
punct |
(,data |
R6060 |
T9177 |
T9170 |
parataxis |
data,differences |
R6061 |
T9178 |
T9177 |
dep |
TB,data |
R6062 |
T9179 |
T9178 |
cc |
and,TB |
R6063 |
T9180 |
T9178 |
conj |
ATS,TB |
R6064 |
T9181 |
T9177 |
punct |
", ",data |
R6065 |
T9182 |
T9177 |
amod |
unpublished,data |
R6066 |
T9183 |
T9177 |
punct |
),data |
R6067 |
T9184 |
T9185 |
det |
the,notion |
R6068 |
T9185 |
T9157 |
dobj |
notion,supported |
R6069 |
T9186 |
T9187 |
mark |
that,resulted |
R6070 |
T9187 |
T9185 |
acl |
resulted,notion |
R6071 |
T9188 |
T9189 |
compound |
GluR,B |
R6072 |
T9189 |
T9191 |
compound |
B,depletion |
R6073 |
T9190 |
T9189 |
punct |
-,B |
R6074 |
T9191 |
T9187 |
nsubj |
depletion,resulted |
R6075 |
T9192 |
T9187 |
prep |
in,resulted |
R6076 |
T9193 |
T9194 |
amod |
enhanced,capability |
R6077 |
T9194 |
T9192 |
pobj |
capability,in |
R6078 |
T9195 |
T9196 |
compound |
odor,discrimination |
R6079 |
T9196 |
T9194 |
compound |
discrimination,capability |
R6080 |
T9197 |
T9157 |
punct |
.,supported |
R6081 |
T9199 |
T9200 |
det |
The,phenotype |
R6082 |
T9200 |
T9202 |
nsubj |
phenotype,be |
R6083 |
T9201 |
T9200 |
compound |
learning,phenotype |
R6084 |
T9203 |
T9202 |
aux |
might,be |
R6085 |
T9204 |
T9202 |
advmod |
thus,be |
R6086 |
T9205 |
T9206 |
det |
a,result |
R6087 |
T9206 |
T9202 |
attr |
result,be |
R6088 |
T9207 |
T9206 |
prep |
of,result |
R6089 |
T9208 |
T9209 |
det |
this,capability |
R6090 |
T9209 |
T9207 |
pobj |
capability,of |
R6091 |
T9210 |
T9209 |
amod |
enhanced,capability |
R6092 |
T9211 |
T9209 |
compound |
discrimination,capability |
R6093 |
T9212 |
T9202 |
cc |
or,be |
R6094 |
T9213 |
T9202 |
conj |
reflect,be |
R6095 |
T9214 |
T9215 |
amod |
additional,changes |
R6096 |
T9215 |
T9213 |
dobj |
changes,reflect |
R6097 |
T9216 |
T9215 |
prep |
in,changes |
R6098 |
T9217 |
T9216 |
pobj |
circuits,in |
R6099 |
T9218 |
T9217 |
acl |
underlying,circuits |
R6100 |
T9219 |
T9220 |
compound |
task,acquisition |
R6101 |
T9220 |
T9218 |
dobj |
acquisition,underlying |
R6102 |
T9221 |
T9202 |
punct |
.,be |
R6103 |
T9487 |
T9488 |
amod |
Putative,Basis |
R6104 |
T9489 |
T9488 |
amod |
Cellular,Basis |
R6105 |
T9490 |
T9488 |
prep |
of,Basis |
R6106 |
T9491 |
T9492 |
amod |
Enhanced,Discrimination |
R6107 |
T9492 |
T9490 |
pobj |
Discrimination,of |
R6108 |
T9493 |
T9492 |
compound |
Odor,Discrimination |
R6109 |
T9494 |
T9492 |
cc |
and,Discrimination |
R6110 |
T9495 |
T9492 |
conj |
Learning,Discrimination |
R6111 |
T9497 |
T9498 |
compound |
AMPAR,properties |
R6112 |
T9498 |
T9499 |
nsubjpass |
properties,altered |
R6113 |
T9500 |
T9499 |
auxpass |
were,altered |
R6114 |
T9501 |
T9502 |
advmod |
specifically,in |
R6115 |
T9502 |
T9499 |
prep |
in,altered |
R6116 |
T9503 |
T9502 |
pobj |
neurons,in |
R6117 |
T9504 |
T9503 |
prep |
of,neurons |
R6118 |
T9505 |
T9506 |
compound |
forebrain,areas |
R6119 |
T9506 |
T9504 |
pobj |
areas,of |
R6120 |
T9507 |
T9506 |
punct |
", ",areas |
R6121 |
T9508 |
T9509 |
advmod |
most,notably |
R6122 |
T9509 |
T9510 |
advmod |
notably,bulb |
R6123 |
T9510 |
T9506 |
appos |
bulb,areas |
R6124 |
T9511 |
T9510 |
amod |
olfactory,bulb |
R6125 |
T9512 |
T9510 |
punct |
", ",bulb |
R6126 |
T9513 |
T9514 |
amod |
olfactory,cortex |
R6127 |
T9514 |
T9510 |
conj |
cortex,bulb |
R6128 |
T9515 |
T9514 |
punct |
", ",cortex |
R6129 |
T9516 |
T9514 |
cc |
and,cortex |
R6130 |
T9517 |
T9518 |
amod |
other,areas |
R6131 |
T9518 |
T9514 |
conj |
areas,cortex |
R6132 |
T9519 |
T9518 |
amod |
cortical,areas |
R6133 |
T9520 |
T9506 |
cc |
and,areas |
R6134 |
T9521 |
T9506 |
conj |
hippocampus,areas |
R6135 |
T9522 |
T9499 |
punct |
", ",altered |
R6136 |
T9523 |
T9499 |
advcl |
leading,altered |
R6137 |
T9524 |
T9523 |
prep |
to,leading |
R6138 |
T9525 |
T9526 |
amod |
enhanced,discrimination |
R6139 |
T9526 |
T9524 |
pobj |
discrimination,to |
R6140 |
T9527 |
T9526 |
compound |
odor,discrimination |
R6141 |
T9528 |
T9526 |
cc |
and,discrimination |
R6142 |
T9529 |
T9526 |
conj |
learning,discrimination |
R6143 |
T9530 |
T9499 |
punct |
.,altered |
R6144 |
T9532 |
T9533 |
advmod |
Interestingly,alter |
R6145 |
T9534 |
T9533 |
punct |
", ",alter |
R6146 |
T9535 |
T9536 |
amod |
transgenic,expression |
R6147 |
T9536 |
T9533 |
nsubj |
expression,alter |
R6148 |
T9537 |
T9536 |
prep |
of,expression |
R6149 |
T9538 |
T9539 |
compound |
GFPGluR,B |
R6150 |
T9539 |
T9537 |
pobj |
B,of |
R6151 |
T9540 |
T9539 |
punct |
-,B |
R6152 |
T9541 |
T9536 |
prep |
in,expression |
R6153 |
T9542 |
T9543 |
compound |
GluR,BΔFB |
R6154 |
T9543 |
T9545 |
compound |
BΔFB,mice |
R6155 |
T9544 |
T9543 |
punct |
-,BΔFB |
R6156 |
T9545 |
T9541 |
pobj |
mice,in |
R6157 |
T9546 |
T9547 |
punct |
(,rescue |
R6158 |
T9547 |
T9545 |
parataxis |
rescue,mice |
R6159 |
T9548 |
T9547 |
amod |
genetic,rescue |
R6160 |
T9549 |
T9547 |
punct |
“,rescue |
R6161 |
T9550 |
T9547 |
punct |
”,rescue |
R6162 |
T9551 |
T9547 |
punct |
),rescue |
R6163 |
T9552 |
T9536 |
punct |
", ",expression |
R6164 |
T9553 |
T9554 |
advmod |
specifically,in |
R6165 |
T9554 |
T9536 |
prep |
in,expression |
R6166 |
T9555 |
T9556 |
amod |
piriform,cortex |
R6167 |
T9556 |
T9554 |
pobj |
cortex,in |
R6168 |
T9557 |
T9556 |
cc |
and,cortex |
R6169 |
T9558 |
T9556 |
conj |
hippocampus,cortex |
R6170 |
T9559 |
T9556 |
prep |
with,cortex |
R6171 |
T9560 |
T9561 |
det |
no,expression |
R6172 |
T9561 |
T9559 |
pobj |
expression,with |
R6173 |
T9562 |
T9561 |
amod |
detectable,expression |
R6174 |
T9563 |
T9561 |
prep |
in,expression |
R6175 |
T9564 |
T9565 |
det |
the,bulb |
R6176 |
T9565 |
T9563 |
pobj |
bulb,in |
R6177 |
T9566 |
T9565 |
amod |
olfactory,bulb |
R6178 |
T9567 |
T9533 |
punct |
", ",alter |
R6179 |
T9568 |
T9533 |
aux |
did,alter |
R6180 |
T9569 |
T9533 |
neg |
not,alter |
R6181 |
T9570 |
T9571 |
amod |
enhanced,capabilities |
R6182 |
T9571 |
T9533 |
dobj |
capabilities,alter |
R6183 |
T9572 |
T9571 |
nmod |
discrimination,capabilities |
R6184 |
T9573 |
T9572 |
cc |
and,discrimination |
R6185 |
T9574 |
T9572 |
conj |
learning,discrimination |
R6186 |
T9575 |
T9533 |
punct |
.,alter |
R6187 |
T9577 |
T9578 |
nsubj |
This,is |
R6188 |
T9579 |
T9578 |
acomp |
consistent,is |
R6189 |
T9580 |
T9579 |
prep |
with,consistent |
R6190 |
T9581 |
T9582 |
det |
a,role |
R6191 |
T9582 |
T9580 |
pobj |
role,with |
R6192 |
T9583 |
T9582 |
amod |
primary,role |
R6193 |
T9584 |
T9582 |
prep |
of,role |
R6194 |
T9585 |
T9586 |
det |
the,bulb |
R6195 |
T9586 |
T9584 |
pobj |
bulb,of |
R6196 |
T9587 |
T9586 |
amod |
olfactory,bulb |
R6197 |
T9588 |
T9582 |
prep |
in,role |
R6198 |
T9589 |
T9590 |
amod |
olfactory,discrimination |
R6199 |
T9590 |
T9588 |
pobj |
discrimination,in |
R6200 |
T9591 |
T9590 |
cc |
and,discrimination |
R6201 |
T9592 |
T9590 |
conj |
learning,discrimination |
R6202 |
T9593 |
T9578 |
punct |
.,is |
R6203 |
T9595 |
T9596 |
advmod |
Alternatively,been |
R6204 |
T9597 |
T9596 |
punct |
", ",been |
R6205 |
T9598 |
T9599 |
amod |
transgenic,levels |
R6206 |
T9599 |
T9596 |
nsubj |
levels,been |
R6207 |
T9600 |
T9599 |
compound |
protein,levels |
R6208 |
T9601 |
T9596 |
aux |
might,been |
R6209 |
T9602 |
T9596 |
aux |
have,been |
R6210 |
T9603 |
T9604 |
advmod |
too,low |
R6211 |
T9604 |
T9596 |
acomp |
low,been |
R6212 |
T9605 |
T9606 |
aux |
to,alter |
R6213 |
T9606 |
T9604 |
xcomp |
alter,low |
R6214 |
T9607 |
T9608 |
nmod |
discrimination,capabilities |
R6215 |
T9608 |
T9606 |
dobj |
capabilities,alter |
R6216 |
T9609 |
T9607 |
cc |
and,discrimination |
R6217 |
T9610 |
T9607 |
conj |
learning,discrimination |
R6218 |
T9611 |
T9596 |
punct |
", ",been |
R6219 |
T9612 |
T9613 |
mark |
although,affected |
R6220 |
T9613 |
T9596 |
advcl |
affected,been |
R6221 |
T9614 |
T9613 |
nsubjpass |
memory,affected |
R6222 |
T9615 |
T9613 |
auxpass |
was,affected |
R6223 |
T9616 |
T9613 |
advmod |
clearly,affected |
R6224 |
T9617 |
T9596 |
punct |
.,been |
R6225 |
T9619 |
T9620 |
det |
This,notion |
R6226 |
T9620 |
T9621 |
nsubjpass |
notion,tested |
R6227 |
T9622 |
T9621 |
aux |
will,tested |
R6228 |
T9623 |
T9621 |
auxpass |
be,tested |
R6229 |
T9624 |
T9621 |
advmod |
further,tested |
R6230 |
T9625 |
T9621 |
prep |
in,tested |
R6231 |
T9626 |
T9625 |
pobj |
mice,in |
R6232 |
T9627 |
T9626 |
prep |
with,mice |
R6233 |
T9628 |
T9629 |
amod |
piriform,cortex |
R6234 |
T9629 |
T9630 |
npadvmod |
cortex,specific |
R6235 |
T9630 |
T9632 |
amod |
specific,ablation |
R6236 |
T9631 |
T9630 |
punct |
-,specific |
R6237 |
T9632 |
T9627 |
pobj |
ablation,with |
R6238 |
T9633 |
T9634 |
compound |
GluR,B |
R6239 |
T9634 |
T9632 |
compound |
B,ablation |
R6240 |
T9635 |
T9634 |
punct |
-,B |
R6241 |
T9636 |
T9621 |
punct |
.,tested |
R6242 |
T9638 |
T9639 |
det |
A,contribution |
R6243 |
T9639 |
T9641 |
nsubj |
contribution,seems |
R6244 |
T9640 |
T9639 |
amod |
direct,contribution |
R6245 |
T9642 |
T9639 |
prep |
to,contribution |
R6246 |
T9643 |
T9644 |
det |
the,phenotype |
R6247 |
T9644 |
T9642 |
pobj |
phenotype,to |
R6248 |
T9645 |
T9639 |
prep |
by,contribution |
R6249 |
T9646 |
T9647 |
nmod |
Ca2,influx |
R6250 |
T9647 |
T9645 |
pobj |
influx,by |
R6251 |
T9648 |
T9646 |
punct |
+,Ca2 |
R6252 |
T9649 |
T9647 |
prep |
through,influx |
R6253 |
T9650 |
T9651 |
advmod |
genetically,modified |
R6254 |
T9651 |
T9652 |
amod |
modified,channels |
R6255 |
T9652 |
T9649 |
pobj |
channels,through |
R6256 |
T9653 |
T9652 |
compound |
AMPA,channels |
R6257 |
T9654 |
T9655 |
aux |
to,be |
R6258 |
T9655 |
T9641 |
xcomp |
be,seems |
R6259 |
T9656 |
T9655 |
acomp |
likely,be |
R6260 |
T9657 |
T9641 |
punct |
", ",seems |
R6261 |
T9658 |
T9659 |
mark |
since,showed |
R6262 |
T9659 |
T9641 |
advcl |
showed,seems |
R6263 |
T9660 |
T9659 |
nsubj |
mice,showed |
R6264 |
T9661 |
T9660 |
acl |
expressing,mice |
R6265 |
T9662 |
T9663 |
nmod |
Q,R |
R6266 |
T9663 |
T9665 |
nmod |
R,B |
R6267 |
T9664 |
T9663 |
punct |
/,R |
R6268 |
T9665 |
T9661 |
dobj |
B,expressing |
R6269 |
T9666 |
T9667 |
npadvmod |
site,unedited |
R6270 |
T9667 |
T9665 |
amod |
unedited,B |
R6271 |
T9668 |
T9667 |
punct |
-,unedited |
R6272 |
T9669 |
T9665 |
compound |
GluR,B |
R6273 |
T9670 |
T9665 |
punct |
-,B |
R6274 |
T9671 |
T9672 |
advmod |
even,better |
R6275 |
T9672 |
T9673 |
amod |
better,performance |
R6276 |
T9673 |
T9659 |
dobj |
performance,showed |
R6277 |
T9674 |
T9675 |
nmod |
odor,learning |
R6278 |
T9675 |
T9673 |
nmod |
learning,performance |
R6279 |
T9676 |
T9675 |
cc |
and,learning |
R6280 |
T9677 |
T9675 |
conj |
discrimination,learning |
R6281 |
T9678 |
T9659 |
prep |
compared,showed |
R6282 |
T9679 |
T9678 |
prep |
with,compared |
R6283 |
T9680 |
T9679 |
pobj |
mice,with |
R6284 |
T9681 |
T9680 |
prep |
with,mice |
R6285 |
T9682 |
T9683 |
amod |
depleted,B |
R6286 |
T9683 |
T9681 |
pobj |
B,with |
R6287 |
T9684 |
T9683 |
compound |
GluR,B |
R6288 |
T9685 |
T9683 |
punct |
-,B |
R6289 |
T9686 |
T9641 |
punct |
.,seems |
R6290 |
T9688 |
T9689 |
prep |
In,increased |
R6291 |
T9690 |
T9691 |
det |
both,models |
R6292 |
T9691 |
T9688 |
pobj |
models,In |
R6293 |
T9692 |
T9691 |
compound |
mouse,models |
R6294 |
T9693 |
T9694 |
nmod |
Ca2,influx |
R6295 |
T9694 |
T9689 |
nsubjpass |
influx,increased |
R6296 |
T9695 |
T9693 |
punct |
+,Ca2 |
R6297 |
T9696 |
T9694 |
prep |
through,influx |
R6298 |
T9697 |
T9698 |
compound |
AMPA,channels |
R6299 |
T9698 |
T9696 |
pobj |
channels,through |
R6300 |
T9699 |
T9689 |
auxpass |
is,increased |
R6301 |
T9700 |
T9689 |
punct |
", ",increased |
R6302 |
T9701 |
T9702 |
mark |
whereas,differs |
R6303 |
T9702 |
T9689 |
advcl |
differs,increased |
R6304 |
T9703 |
T9704 |
det |
the,effect |
R6305 |
T9704 |
T9702 |
nsubj |
effect,differs |
R6306 |
T9705 |
T9704 |
prep |
on,effect |
R6307 |
T9706 |
T9707 |
det |
the,conductance |
R6308 |
T9707 |
T9705 |
pobj |
conductance,on |
R6309 |
T9708 |
T9707 |
amod |
macroscopic,conductance |
R6310 |
T9709 |
T9707 |
compound |
AMPA,conductance |
R6311 |
T9710 |
T9689 |
punct |
.,increased |
R6312 |
T9712 |
T9713 |
compound |
AMPAR,currents |
R6313 |
T9713 |
T9714 |
nsubjpass |
currents,reduced |
R6314 |
T9715 |
T9714 |
auxpass |
are,reduced |
R6315 |
T9716 |
T9714 |
prep |
in,reduced |
R6316 |
T9717 |
T9716 |
pobj |
mice,in |
R6317 |
T9718 |
T9719 |
neg |
not,expressing |
R6318 |
T9719 |
T9717 |
acl |
expressing,mice |
R6319 |
T9720 |
T9721 |
compound |
GluR,B |
R6320 |
T9721 |
T9719 |
dobj |
B,expressing |
R6321 |
T9722 |
T9721 |
punct |
-,B |
R6322 |
T9723 |
T9724 |
punct |
[,51 |
R6323 |
T9724 |
T9714 |
parataxis |
51,reduced |
R6324 |
T9725 |
T9724 |
punct |
],51 |
R6325 |
T9726 |
T9714 |
punct |
", ",reduced |
R6326 |
T9727 |
T9728 |
advmod |
possibly,due |
R6327 |
T9728 |
T9714 |
prep |
due,reduced |
R6328 |
T9729 |
T9728 |
pcomp |
to,due |
R6329 |
T9730 |
T9731 |
amod |
fewer,channels |
R6330 |
T9731 |
T9728 |
pobj |
channels,due |
R6331 |
T9732 |
T9731 |
amod |
synaptic,channels |
R6332 |
T9733 |
T9731 |
compound |
AMPA,channels |
R6333 |
T9734 |
T9731 |
cc |
and,channels |
R6334 |
T9735 |
T9736 |
amod |
impaired,trafficking |
R6335 |
T9736 |
T9731 |
conj |
trafficking,channels |
R6336 |
T9737 |
T9736 |
compound |
AMPAR,trafficking |
R6337 |
T9738 |
T9736 |
cc |
and,trafficking |
R6338 |
T9739 |
T9736 |
conj |
recycling,trafficking |
R6339 |
T9740 |
T9714 |
punct |
.,reduced |
R6340 |
T9742 |
T9743 |
prep |
In,increased |
R6341 |
T9744 |
T9742 |
pobj |
mice,In |
R6342 |
T9745 |
T9744 |
acl |
expressing,mice |
R6343 |
T9746 |
T9747 |
det |
the,form |
R6344 |
T9747 |
T9745 |
dobj |
form,expressing |
R6345 |
T9748 |
T9747 |
amod |
unedited,form |
R6346 |
T9749 |
T9747 |
prep |
of,form |
R6347 |
T9750 |
T9751 |
nmod |
GluR,Q |
R6348 |
T9751 |
T9749 |
pobj |
Q,of |
R6349 |
T9752 |
T9751 |
punct |
-,Q |
R6350 |
T9753 |
T9751 |
nmod |
B,Q |
R6351 |
T9754 |
T9751 |
punct |
(,Q |
R6352 |
T9755 |
T9751 |
punct |
),Q |
R6353 |
T9756 |
T9743 |
punct |
", ",increased |
R6354 |
T9757 |
T9758 |
amod |
macroscopic,conductance |
R6355 |
T9758 |
T9743 |
nsubjpass |
conductance,increased |
R6356 |
T9759 |
T9758 |
prep |
in,conductance |
R6357 |
T9760 |
T9761 |
amod |
whole,cell |
R6358 |
T9761 |
T9763 |
compound |
cell,patches |
R6359 |
T9762 |
T9761 |
punct |
-,cell |
R6360 |
T9763 |
T9759 |
pobj |
patches,in |
R6361 |
T9764 |
T9763 |
prep |
of,patches |
R6362 |
T9765 |
T9766 |
compound |
CA1,pyramidals |
R6363 |
T9766 |
T9764 |
pobj |
pyramidals,of |
R6364 |
T9767 |
T9743 |
auxpass |
is,increased |
R6365 |
T9768 |
T9769 |
punct |
[,60 |
R6366 |
T9769 |
T9743 |
parataxis |
60,increased |
R6367 |
T9770 |
T9769 |
punct |
],60 |
R6368 |
T9771 |
T9743 |
punct |
", ",increased |
R6369 |
T9772 |
T9743 |
cc |
but,increased |
R6370 |
T9773 |
T9774 |
amod |
excitatory,transmission |
R6371 |
T9774 |
T9775 |
nsubj |
transmission,is |
R6372 |
T9775 |
T9743 |
conj |
is,increased |
R6373 |
T9776 |
T9774 |
prep |
in,transmission |
R6374 |
T9777 |
T9778 |
nmod |
CA3,synapses |
R6375 |
T9778 |
T9776 |
pobj |
synapses,in |
R6376 |
T9779 |
T9777 |
punct |
-,CA3 |
R6377 |
T9780 |
T9777 |
prep |
to,CA3 |
R6378 |
T9781 |
T9780 |
punct |
-,to |
R6379 |
T9782 |
T9780 |
pobj |
CA1,to |
R6380 |
T9783 |
T9778 |
compound |
cell,synapses |
R6381 |
T9784 |
T9785 |
advmod |
somewhat,reduced |
R6382 |
T9785 |
T9775 |
acomp |
reduced,is |
R6383 |
T9786 |
T9775 |
punct |
", ",is |
R6384 |
T9787 |
T9775 |
prep |
in,is |
R6385 |
T9788 |
T9787 |
pobj |
spite,in |
R6386 |
T9789 |
T9788 |
prep |
of,spite |
R6387 |
T9790 |
T9791 |
det |
a,threshold |
R6388 |
T9791 |
T9789 |
pobj |
threshold,of |
R6389 |
T9792 |
T9791 |
amod |
lower,threshold |
R6390 |
T9793 |
T9791 |
prep |
for,threshold |
R6391 |
T9794 |
T9793 |
pcomp |
generating,for |
R6392 |
T9795 |
T9796 |
det |
a,spike |
R6393 |
T9796 |
T9794 |
dobj |
spike,generating |
R6394 |
T9797 |
T9796 |
compound |
population,spike |
R6395 |
T9798 |
T9799 |
punct |
[,58 |
R6396 |
T9799 |
T9775 |
parataxis |
58,is |
R6397 |
T9800 |
T9799 |
punct |
],58 |
R6398 |
T9801 |
T9743 |
punct |
", ",increased |
R6399 |
T9802 |
T9743 |
advcl |
indicating,increased |
R6400 |
T9803 |
T9804 |
amod |
increased,excitability |
R6401 |
T9804 |
T9802 |
dobj |
excitability,indicating |
R6402 |
T9805 |
T9804 |
amod |
synaptic,excitability |
R6403 |
T9806 |
T9802 |
prep |
by,indicating |
R6404 |
T9807 |
T9808 |
amod |
sustained,expression |
R6405 |
T9808 |
T9806 |
pobj |
expression,by |
R6406 |
T9809 |
T9810 |
nmod |
GluR,Q |
R6407 |
T9810 |
T9808 |
nmod |
Q,expression |
R6408 |
T9811 |
T9810 |
punct |
-,Q |
R6409 |
T9812 |
T9810 |
nmod |
B,Q |
R6410 |
T9813 |
T9810 |
punct |
(,Q |
R6411 |
T9814 |
T9810 |
punct |
),Q |
R6412 |
T9815 |
T9802 |
punct |
", ",indicating |
R6413 |
T9816 |
T9802 |
prep |
in,indicating |
R6414 |
T9817 |
T9816 |
pobj |
line,in |
R6415 |
T9818 |
T9817 |
prep |
with,line |
R6416 |
T9819 |
T9820 |
det |
the,phenotype |
R6417 |
T9820 |
T9818 |
pobj |
phenotype,with |
R6418 |
T9821 |
T9822 |
npadvmod |
seizure,prone |
R6419 |
T9822 |
T9820 |
amod |
prone,phenotype |
R6420 |
T9823 |
T9822 |
punct |
-,prone |
R6421 |
T9824 |
T9743 |
punct |
.,increased |
R6422 |
T9826 |
T9827 |
advmod |
Yet,yield |
R6423 |
T9828 |
T9827 |
punct |
", ",yield |
R6424 |
T9829 |
T9830 |
det |
both,models |
R6425 |
T9830 |
T9827 |
nsubj |
models,yield |
R6426 |
T9831 |
T9830 |
compound |
mouse,models |
R6427 |
T9832 |
T9833 |
amod |
enhanced,capability |
R6428 |
T9833 |
T9827 |
dobj |
capability,yield |
R6429 |
T9834 |
T9833 |
nmod |
discrimination,capability |
R6430 |
T9835 |
T9834 |
cc |
and,discrimination |
R6431 |
T9836 |
T9834 |
conj |
learning,discrimination |
R6432 |
T9837 |
T9827 |
punct |
.,yield |
R6433 |
T9839 |
T9840 |
det |
The,phenotype |
R6434 |
T9840 |
T9842 |
nsubjpass |
phenotype,attributed |
R6435 |
T9841 |
T9840 |
amod |
milder,phenotype |
R6436 |
T9843 |
T9840 |
prep |
upon,phenotype |
R6437 |
T9844 |
T9845 |
compound |
GluR,B |
R6438 |
T9845 |
T9847 |
compound |
B,depletion |
R6439 |
T9846 |
T9845 |
punct |
-,B |
R6440 |
T9847 |
T9843 |
pobj |
depletion,upon |
R6441 |
T9848 |
T9842 |
aux |
could,attributed |
R6442 |
T9849 |
T9842 |
auxpass |
be,attributed |
R6443 |
T9850 |
T9842 |
prep |
to,attributed |
R6444 |
T9851 |
T9852 |
amod |
reduced,densities |
R6445 |
T9852 |
T9850 |
pobj |
densities,to |
R6446 |
T9853 |
T9852 |
compound |
AMPAR,densities |
R6447 |
T9854 |
T9852 |
prep |
at,densities |
R6448 |
T9855 |
T9854 |
pobj |
synapses,at |
R6449 |
T9856 |
T9857 |
punct |
[,41 |
R6450 |
T9857 |
T9852 |
parataxis |
41,densities |
R6451 |
T9858 |
T9857 |
nummod |
40,41 |
R6452 |
T9859 |
T9857 |
punct |
",",41 |
R6453 |
T9860 |
T9857 |
punct |
],41 |
R6454 |
T9861 |
T9850 |
cc |
and,to |
R6455 |
T9862 |
T9863 |
advmod |
therefore,to |
R6456 |
T9863 |
T9850 |
conj |
to,to |
R6457 |
T9864 |
T9863 |
advmod |
probably,to |
R6458 |
T9865 |
T9866 |
det |
a,extent |
R6459 |
T9866 |
T9863 |
pobj |
extent,to |
R6460 |
T9867 |
T9866 |
amod |
lesser,extent |
R6461 |
T9868 |
T9866 |
prep |
of,extent |
R6462 |
T9869 |
T9870 |
nmod |
Ca2,influx |
R6463 |
T9870 |
T9868 |
pobj |
influx,of |
R6464 |
T9871 |
T9869 |
punct |
+,Ca2 |
R6465 |
T9872 |
T9842 |
punct |
.,attributed |
R6466 |
T9874 |
T9875 |
nsubjpass |
This,supported |
R6467 |
T9876 |
T9875 |
auxpass |
is,supported |
R6468 |
T9877 |
T9875 |
advmod |
further,supported |
R6469 |
T9878 |
T9875 |
agent |
by,supported |
R6470 |
T9879 |
T9880 |
npadvmod |
kainate,induced |
R6471 |
T9880 |
T9882 |
amod |
induced,uptake |
R6472 |
T9881 |
T9880 |
punct |
-,induced |
R6473 |
T9882 |
T9878 |
pobj |
uptake,by |
R6474 |
T9883 |
T9882 |
nmod |
Co2,uptake |
R6475 |
T9884 |
T9883 |
punct |
+,Co2 |
R6476 |
T9885 |
T9875 |
prep |
in,supported |
R6477 |
T9886 |
T9887 |
amod |
acute,slices |
R6478 |
T9887 |
T9885 |
pobj |
slices,in |
R6479 |
T9888 |
T9887 |
compound |
brain,slices |
R6480 |
T9889 |
T9875 |
punct |
", ",supported |
R6481 |
T9890 |
T9875 |
advcl |
revealing,supported |
R6482 |
T9891 |
T9892 |
advmod |
considerably,higher |
R6483 |
T9892 |
T9893 |
amod |
higher,uptake |
R6484 |
T9893 |
T9890 |
dobj |
uptake,revealing |
R6485 |
T9894 |
T9893 |
nmod |
Co2,uptake |
R6486 |
T9895 |
T9894 |
punct |
+,Co2 |
R6487 |
T9896 |
T9893 |
prep |
via,uptake |
R6488 |
T9897 |
T9898 |
npadvmod |
Ca2,permeable |
R6489 |
T9898 |
T9901 |
amod |
permeable,AMPARs |
R6490 |
T9899 |
T9897 |
punct |
+,Ca2 |
R6491 |
T9900 |
T9898 |
punct |
-,permeable |
R6492 |
T9901 |
T9896 |
pobj |
AMPARs,via |
R6493 |
T9902 |
T9890 |
prep |
in,revealing |
R6494 |
T9903 |
T9904 |
amod |
hippocampal,neurons |
R6495 |
T9904 |
T9902 |
pobj |
neurons,in |
R6496 |
T9905 |
T9904 |
amod |
pyramidal,neurons |
R6497 |
T9906 |
T9904 |
prep |
of,neurons |
R6498 |
T9907 |
T9906 |
pobj |
mice,of |
R6499 |
T9908 |
T9907 |
acl |
expressing,mice |
R6500 |
T9909 |
T9910 |
compound |
GluR,B |
R6501 |
T9910 |
T9908 |
dobj |
B,expressing |
R6502 |
T9911 |
T9910 |
punct |
-,B |
R6503 |
T9912 |
T9913 |
punct |
(,Q |
R6504 |
T9913 |
T9908 |
parataxis |
Q,expressing |
R6505 |
T9914 |
T9913 |
punct |
),Q |
R6506 |
T9915 |
T9890 |
punct |
", ",revealing |
R6507 |
T9916 |
T9890 |
prep |
than,revealing |
R6508 |
T9917 |
T9916 |
pobj |
those,than |
R6509 |
T9918 |
T9917 |
acl |
lacking,those |
R6510 |
T9919 |
T9920 |
compound |
GluR,B |
R6511 |
T9920 |
T9918 |
dobj |
B,lacking |
R6512 |
T9921 |
T9920 |
punct |
-,B |
R6513 |
T9922 |
T9923 |
punct |
(,data |
R6514 |
T9923 |
T9875 |
parataxis |
data,supported |
R6515 |
T9924 |
T9923 |
dep |
DRS,data |
R6516 |
T9925 |
T9924 |
punct |
", ",DRS |
R6517 |
T9926 |
T9924 |
conj |
RS,DRS |
R6518 |
T9927 |
T9926 |
punct |
", ",RS |
R6519 |
T9928 |
T9926 |
cc |
and,RS |
R6520 |
T9929 |
T9926 |
conj |
PHS,RS |
R6521 |
T9930 |
T9923 |
punct |
", ",data |
R6522 |
T9931 |
T9923 |
amod |
unpublished,data |
R6523 |
T9932 |
T9923 |
punct |
),data |
R6524 |
T9933 |
T9875 |
punct |
.,supported |
R6525 |
T9935 |
T9936 |
advmod |
Normally,localized |
R6526 |
T9937 |
T9936 |
punct |
", ",localized |
R6527 |
T9938 |
T9939 |
compound |
GluR,B |
R6528 |
T9939 |
T9941 |
npadvmod |
B,containing |
R6529 |
T9940 |
T9939 |
punct |
-,B |
R6530 |
T9941 |
T9943 |
amod |
containing,AMPARs |
R6531 |
T9942 |
T9941 |
punct |
-,containing |
R6532 |
T9943 |
T9936 |
nsubjpass |
AMPARs,localized |
R6533 |
T9944 |
T9936 |
auxpass |
are,localized |
R6534 |
T9945 |
T9936 |
advmod |
prominently,localized |
R6535 |
T9946 |
T9936 |
prep |
at,localized |
R6536 |
T9947 |
T9948 |
det |
the,synapse |
R6537 |
T9948 |
T9946 |
pobj |
synapse,at |
R6538 |
T9949 |
T9948 |
amod |
dendrodendritic,synapse |
R6539 |
T9950 |
T9936 |
prep |
between,localized |
R6540 |
T9951 |
T9952 |
amod |
mitral,cells |
R6541 |
T9952 |
T9950 |
pobj |
cells,between |
R6542 |
T9953 |
T9951 |
cc |
and,mitral |
R6543 |
T9954 |
T9951 |
conj |
granule,mitral |
R6544 |
T9955 |
T9936 |
prep |
in,localized |
R6545 |
T9956 |
T9957 |
det |
the,bulb |
R6546 |
T9957 |
T9955 |
pobj |
bulb,in |
R6547 |
T9958 |
T9957 |
amod |
olfactory,bulb |
R6548 |
T9959 |
T9960 |
punct |
[,65 |
R6549 |
T9960 |
T9936 |
parataxis |
65,localized |
R6550 |
T9961 |
T9960 |
nummod |
64,65 |
R6551 |
T9962 |
T9960 |
punct |
",",65 |
R6552 |
T9963 |
T9960 |
punct |
],65 |
R6553 |
T9964 |
T9936 |
punct |
.,localized |
R6554 |
T9966 |
T9967 |
mark |
As,thought |
R6555 |
T9967 |
T9975 |
advcl |
thought,is |
R6556 |
T9968 |
T9969 |
nmod |
Ca2,influx |
R6557 |
T9969 |
T9967 |
nsubjpass |
influx,thought |
R6558 |
T9970 |
T9968 |
punct |
+,Ca2 |
R6559 |
T9971 |
T9969 |
prep |
through,influx |
R6560 |
T9972 |
T9973 |
compound |
glutamate,receptors |
R6561 |
T9973 |
T9971 |
pobj |
receptors,through |
R6562 |
T9974 |
T9967 |
auxpass |
is,thought |
R6563 |
T9976 |
T9977 |
aux |
to,contribute |
R6564 |
T9977 |
T9967 |
xcomp |
contribute,thought |
R6565 |
T9978 |
T9977 |
prep |
to,contribute |
R6566 |
T9979 |
T9980 |
amod |
lateral,inhibition |
R6567 |
T9980 |
T9978 |
pobj |
inhibition,to |
R6568 |
T9981 |
T9979 |
cc |
and,lateral |
R6569 |
T9982 |
T9979 |
conj |
recurrent,lateral |
R6570 |
T9983 |
T9984 |
punct |
(,38 |
R6571 |
T9984 |
T9977 |
parataxis |
38,contribute |
R6572 |
T9985 |
T9984 |
punct |
[,38 |
R6573 |
T9986 |
T9984 |
punct |
],38 |
R6574 |
T9987 |
T9984 |
advcl |
see,38 |
R6575 |
T9988 |
T9987 |
advmod |
also,see |
R6576 |
T9989 |
T9987 |
punct |
[,see |
R6577 |
T9990 |
T9987 |
dobj |
39,see |
R6578 |
T9991 |
T9984 |
punct |
],38 |
R6579 |
T9992 |
T9984 |
punct |
),38 |
R6580 |
T9993 |
T9975 |
punct |
", ",is |
R6581 |
T9994 |
T9995 |
det |
the,absence |
R6582 |
T9995 |
T9975 |
nsubj |
absence,is |
R6583 |
T9996 |
T9995 |
prep |
of,absence |
R6584 |
T9997 |
T9998 |
compound |
GluR,B |
R6585 |
T9998 |
T9996 |
pobj |
B,of |
R6586 |
T9999 |
T9998 |
punct |
-,B |
R6587 |
T10000 |
T9995 |
punct |
", ",absence |
R6588 |
T10001 |
T9995 |
cc |
or,absence |
R6589 |
T10002 |
T10003 |
det |
the,presence |
R6590 |
T10003 |
T9995 |
conj |
presence,absence |
R6591 |
T10004 |
T10003 |
prep |
of,presence |
R6592 |
T10005 |
T10006 |
compound |
GluR,B |
R6593 |
T10006 |
T10004 |
pobj |
B,of |
R6594 |
T10007 |
T10006 |
punct |
-,B |
R6595 |
T10008 |
T10009 |
punct |
(,Q |
R6596 |
T10009 |
T10003 |
parataxis |
Q,presence |
R6597 |
T10010 |
T10009 |
punct |
),Q |
R6598 |
T10011 |
T9995 |
prep |
in,absence |
R6599 |
T10012 |
T10013 |
det |
the,bulb |
R6600 |
T10013 |
T10011 |
pobj |
bulb,in |
R6601 |
T10014 |
T10013 |
amod |
olfactory,bulb |
R6602 |
T10015 |
T9975 |
punct |
", ",is |
R6603 |
T10016 |
T9975 |
acomp |
likely,is |
R6604 |
T10017 |
T10018 |
aux |
to,result |
R6605 |
T10018 |
T10016 |
xcomp |
result,likely |
R6606 |
T10019 |
T10018 |
prep |
in,result |
R6607 |
T10020 |
T10021 |
amod |
increased,inhibition |
R6608 |
T10021 |
T10019 |
pobj |
inhibition,in |
R6609 |
T10022 |
T10021 |
prep |
between,inhibition |
R6610 |
T10023 |
T10024 |
det |
the,neurons |
R6611 |
T10024 |
T10022 |
pobj |
neurons,between |
R6612 |
T10025 |
T10024 |
amod |
principal,neurons |
R6613 |
T10026 |
T10024 |
prep |
in,neurons |
R6614 |
T10027 |
T10028 |
det |
this,structure |
R6615 |
T10028 |
T10026 |
pobj |
structure,in |
R6616 |
T10029 |
T9975 |
punct |
.,is |
R6617 |
T10031 |
T10032 |
advmod |
Notably,were |
R6618 |
T10033 |
T10032 |
punct |
", ",were |
R6619 |
T10034 |
T10035 |
det |
the,capabilities |
R6620 |
T10035 |
T10032 |
nsubj |
capabilities,were |
R6621 |
T10036 |
T10035 |
amod |
improved,capabilities |
R6622 |
T10037 |
T10038 |
amod |
olfactory,discrimination |
R6623 |
T10038 |
T10035 |
compound |
discrimination,capabilities |
R6624 |
T10039 |
T10032 |
acomp |
apparent,were |
R6625 |
T10040 |
T10041 |
advmod |
even,upon |
R6626 |
T10041 |
T10032 |
prep |
upon,were |
R6627 |
T10042 |
T10043 |
advmod |
relatively,small |
R6628 |
T10043 |
T10044 |
amod |
small,reductions |
R6629 |
T10044 |
T10041 |
pobj |
reductions,upon |
R6630 |
T10045 |
T10044 |
prep |
in,reductions |
R6631 |
T10046 |
T10047 |
compound |
GluR,B |
R6632 |
T10047 |
T10049 |
compound |
B,levels |
R6633 |
T10048 |
T10047 |
punct |
-,B |
R6634 |
T10049 |
T10045 |
pobj |
levels,in |
R6635 |
T10050 |
T10032 |
punct |
.,were |
R6636 |
T10052 |
T10053 |
nsubj |
It,be |
R6637 |
T10054 |
T10053 |
aux |
will,be |
R6638 |
T10055 |
T10053 |
acomp |
interesting,be |
R6639 |
T10056 |
T10057 |
aux |
to,see |
R6640 |
T10057 |
T10053 |
xcomp |
see,be |
R6641 |
T10058 |
T10059 |
mark |
if,exhibit |
R6642 |
T10059 |
T10057 |
ccomp |
exhibit,see |
R6643 |
T10060 |
T10061 |
nmod |
GluR,B |
R6644 |
T10061 |
T10063 |
nmod |
B,mice |
R6645 |
T10062 |
T10061 |
punct |
-,B |
R6646 |
T10063 |
T10059 |
nsubj |
mice,exhibit |
R6647 |
T10064 |
T10061 |
punct |
+,B |
R6648 |
T10065 |
T10061 |
punct |
/,B |
R6649 |
T10066 |
T10061 |
appos |
neo,B |
R6650 |
T10067 |
T10059 |
advmod |
also,exhibit |
R6651 |
T10068 |
T10069 |
amod |
enhanced,discrimination |
R6652 |
T10069 |
T10059 |
dobj |
discrimination,exhibit |
R6653 |
T10070 |
T10069 |
compound |
odor,discrimination |
R6654 |
T10071 |
T10059 |
punct |
", ",exhibit |
R6655 |
T10072 |
T10073 |
dep |
which,is |
R6656 |
T10073 |
T10059 |
advcl |
is,exhibit |
R6657 |
T10074 |
T10073 |
advmod |
indeed,is |
R6658 |
T10075 |
T10073 |
acomp |
likely,is |
R6659 |
T10076 |
T10073 |
prep |
given,is |
R6660 |
T10077 |
T10078 |
mark |
that,arise |
R6661 |
T10078 |
T10076 |
pcomp |
arise,given |
R6662 |
T10079 |
T10080 |
amod |
low,levels |
R6663 |
T10080 |
T10078 |
nsubj |
levels,arise |
R6664 |
T10081 |
T10080 |
prep |
of,levels |
R6665 |
T10082 |
T10083 |
nmod |
GluR,Q |
R6666 |
T10083 |
T10081 |
pobj |
Q,of |
R6667 |
T10084 |
T10083 |
punct |
-,Q |
R6668 |
T10085 |
T10083 |
nmod |
B,Q |
R6669 |
T10086 |
T10083 |
punct |
(,Q |
R6670 |
T10087 |
T10083 |
punct |
),Q |
R6671 |
T10088 |
T10080 |
punct |
", ",levels |
R6672 |
T10089 |
T10080 |
cc |
and,levels |
R6673 |
T10090 |
T10091 |
advmod |
hence,increase |
R6674 |
T10091 |
T10080 |
conj |
increase,levels |
R6675 |
T10092 |
T10091 |
det |
a,increase |
R6676 |
T10093 |
T10091 |
amod |
small,increase |
R6677 |
T10094 |
T10091 |
prep |
in,increase |
R6678 |
T10095 |
T10096 |
npadvmod |
Ca2,permeable |
R6679 |
T10096 |
T10099 |
amod |
permeable,AMPARs |
R6680 |
T10097 |
T10095 |
punct |
+,Ca2 |
R6681 |
T10098 |
T10096 |
punct |
-,permeable |
R6682 |
T10099 |
T10094 |
pobj |
AMPARs,in |
R6683 |
T10100 |
T10078 |
punct |
", ",arise |
R6684 |
T10101 |
T10078 |
prep |
from,arise |
R6685 |
T10102 |
T10103 |
det |
the,allele |
R6686 |
T10103 |
T10101 |
pobj |
allele,from |
R6687 |
T10104 |
T10103 |
amod |
attenuated,allele |
R6688 |
T10105 |
T10106 |
compound |
GluR,Bneo |
R6689 |
T10106 |
T10103 |
compound |
Bneo,allele |
R6690 |
T10107 |
T10106 |
punct |
-,Bneo |
R6691 |
T10108 |
T10109 |
punct |
[,60 |
R6692 |
T10109 |
T10078 |
parataxis |
60,arise |
R6693 |
T10110 |
T10109 |
punct |
],60 |
R6694 |
T10111 |
T10078 |
punct |
", ",arise |
R6695 |
T10112 |
T10078 |
cc |
and,arise |
R6696 |
T10113 |
T10078 |
punct |
", ",arise |
R6697 |
T10114 |
T10115 |
advmod |
moreover,decreased |
R6698 |
T10115 |
T10078 |
conj |
decreased,arise |
R6699 |
T10116 |
T10115 |
punct |
", ",decreased |
R6700 |
T10117 |
T10115 |
mark |
that,decreased |
R6701 |
T10118 |
T10119 |
compound |
GluR,B |
R6702 |
T10119 |
T10121 |
compound |
B,levels |
R6703 |
T10120 |
T10119 |
punct |
-,B |
R6704 |
T10121 |
T10115 |
nsubjpass |
levels,decreased |
R6705 |
T10122 |
T10115 |
auxpass |
are,decreased |
R6706 |
T10123 |
T10115 |
prep |
in,decreased |
R6707 |
T10124 |
T10125 |
det |
these,mice |
R6708 |
T10125 |
T10123 |
pobj |
mice,in |
R6709 |
T10126 |
T10115 |
prep |
due,decreased |
R6710 |
T10127 |
T10126 |
pcomp |
to,due |
R6711 |
T10128 |
T10129 |
det |
the,copy |
R6712 |
T10129 |
T10126 |
pobj |
copy,due |
R6713 |
T10130 |
T10129 |
amod |
single,copy |
R6714 |
T10131 |
T10129 |
prep |
of,copy |
R6715 |
T10132 |
T10133 |
det |
the,allele |
R6716 |
T10133 |
T10131 |
pobj |
allele,of |
R6717 |
T10134 |
T10135 |
nmod |
GluR,B |
R6718 |
T10135 |
T10133 |
nmod |
B,allele |
R6719 |
T10136 |
T10135 |
punct |
-,B |
R6720 |
T10137 |
T10135 |
punct |
+,B |
R6721 |
T10138 |
T10053 |
punct |
.,be |
R6722 |
T10140 |
T10141 |
prep |
In,plays |
R6723 |
T10142 |
T10143 |
advmod |
virtually,models |
R6724 |
T10143 |
T10140 |
pobj |
models,In |
R6725 |
T10144 |
T10143 |
det |
all,models |
R6726 |
T10145 |
T10143 |
prep |
of,models |
R6727 |
T10146 |
T10147 |
det |
the,bulb |
R6728 |
T10147 |
T10145 |
pobj |
bulb,of |
R6729 |
T10148 |
T10147 |
amod |
olfactory,bulb |
R6730 |
T10149 |
T10141 |
punct |
", ",plays |
R6731 |
T10150 |
T10151 |
amod |
lateral,inhibition |
R6732 |
T10151 |
T10141 |
nsubj |
inhibition,plays |
R6733 |
T10152 |
T10150 |
punct |
(,lateral |
R6734 |
T10153 |
T10150 |
cc |
and,lateral |
R6735 |
T10154 |
T10155 |
punct |
", ",in |
R6736 |
T10155 |
T10156 |
parataxis |
in,recurrent |
R6737 |
T10156 |
T10150 |
conj |
recurrent,lateral |
R6738 |
T10157 |
T10158 |
amod |
fewer,models |
R6739 |
T10158 |
T10155 |
pobj |
models,in |
R6740 |
T10159 |
T10155 |
punct |
", ",in |
R6741 |
T10160 |
T10156 |
advmod |
also,recurrent |
R6742 |
T10161 |
T10151 |
punct |
),inhibition |
R6743 |
T10162 |
T10163 |
det |
a,role |
R6744 |
T10163 |
T10141 |
dobj |
role,plays |
R6745 |
T10164 |
T10163 |
amod |
dominant,role |
R6746 |
T10165 |
T10141 |
punct |
", ",plays |
R6747 |
T10166 |
T10167 |
preconj |
either,in |
R6748 |
T10167 |
T10141 |
prep |
in,plays |
R6749 |
T10168 |
T10167 |
pcomp |
establishing,in |
R6750 |
T10169 |
T10170 |
amod |
spatiotemporal,dynamics |
R6751 |
T10170 |
T10168 |
dobj |
dynamics,establishing |
R6752 |
T10171 |
T10172 |
punct |
[,66 |
R6753 |
T10172 |
T10168 |
parataxis |
66,establishing |
R6754 |
T10173 |
T10172 |
dep |
32,66 |
R6755 |
T10174 |
T10172 |
punct |
",",66 |
R6756 |
T10175 |
T10176 |
punct |
–,69 |
R6757 |
T10176 |
T10172 |
prep |
69,66 |
R6758 |
T10177 |
T10172 |
punct |
],66 |
R6759 |
T10178 |
T10167 |
punct |
", ",in |
R6760 |
T10179 |
T10167 |
cc |
or,in |
R6761 |
T10180 |
T10167 |
conj |
in,in |
R6762 |
T10181 |
T10182 |
advmod |
directly,enhancing |
R6763 |
T10182 |
T10180 |
pcomp |
enhancing,in |
R6764 |
T10183 |
T10182 |
dobj |
contrast,enhancing |
R6765 |
T10184 |
T10182 |
cc |
and,enhancing |
R6766 |
T10185 |
T10186 |
advmod |
therefore,simplifying |
R6767 |
T10186 |
T10182 |
conj |
simplifying,enhancing |
R6768 |
T10187 |
T10186 |
dobj |
discrimination,simplifying |
R6769 |
T10188 |
T10187 |
cc |
and,discrimination |
R6770 |
T10189 |
T10187 |
conj |
learning,discrimination |
R6771 |
T10190 |
T10187 |
prep |
of,discrimination |
R6772 |
T10191 |
T10192 |
amod |
similar,odorants |
R6773 |
T10192 |
T10190 |
pobj |
odorants,of |
R6774 |
T10193 |
T10194 |
punct |
[,36 |
R6775 |
T10194 |
T10186 |
parataxis |
36,simplifying |
R6776 |
T10195 |
T10194 |
nummod |
24,36 |
R6777 |
T10196 |
T10194 |
punct |
",",36 |
R6778 |
T10197 |
T10194 |
nummod |
28,36 |
R6779 |
T10198 |
T10194 |
punct |
",",36 |
R6780 |
T10199 |
T10194 |
nummod |
29,36 |
R6781 |
T10200 |
T10194 |
punct |
",",36 |
R6782 |
T10201 |
T10194 |
punct |
],36 |
R6783 |
T10202 |
T10141 |
punct |
.,plays |
R6784 |
T10204 |
T10205 |
amod |
Increased,inhibition |
R6785 |
T10205 |
T10206 |
nsubj |
inhibition,improve |
R6786 |
T10207 |
T10206 |
aux |
will,improve |
R6787 |
T10208 |
T10206 |
advmod |
thus,improve |
R6788 |
T10209 |
T10206 |
prep |
in,improve |
R6789 |
T10210 |
T10209 |
amod |
general,in |
R6790 |
T10211 |
T10206 |
dobj |
discriminability,improve |
R6791 |
T10212 |
T10206 |
punct |
", ",improve |
R6792 |
T10213 |
T10206 |
advcl |
consistent,improve |
R6793 |
T10214 |
T10213 |
prep |
with,consistent |
R6794 |
T10215 |
T10216 |
det |
the,improvements |
R6795 |
T10216 |
T10214 |
pobj |
improvements,with |
R6796 |
T10217 |
T10216 |
amod |
behavioral,improvements |
R6797 |
T10218 |
T10216 |
acl |
observed,improvements |
R6798 |
T10219 |
T10218 |
prep |
with,observed |
R6799 |
T10220 |
T10221 |
nmod |
GluR,Q |
R6800 |
T10221 |
T10225 |
nmod |
Q,expression |
R6801 |
T10222 |
T10221 |
punct |
-,Q |
R6802 |
T10223 |
T10221 |
nmod |
B,Q |
R6803 |
T10224 |
T10221 |
punct |
(,Q |
R6804 |
T10225 |
T10219 |
pobj |
expression,with |
R6805 |
T10226 |
T10221 |
punct |
),Q |
R6806 |
T10227 |
T10225 |
punct |
", ",expression |
R6807 |
T10228 |
T10229 |
det |
the,knockout |
R6808 |
T10229 |
T10225 |
conj |
knockout,expression |
R6809 |
T10230 |
T10231 |
compound |
GluR,B |
R6810 |
T10231 |
T10229 |
compound |
B,knockout |
R6811 |
T10232 |
T10231 |
punct |
-,B |
R6812 |
T10233 |
T10229 |
punct |
", ",knockout |
R6813 |
T10234 |
T10229 |
cc |
and,knockout |
R6814 |
T10235 |
T10236 |
det |
the,mice |
R6815 |
T10236 |
T10229 |
conj |
mice,knockout |
R6816 |
T10237 |
T10236 |
punct |
“,mice |
R6817 |
T10238 |
T10236 |
nmod |
rescue,mice |
R6818 |
T10239 |
T10236 |
punct |
”,mice |
R6819 |
T10240 |
T10206 |
punct |
.,improve |
R6820 |
T10242 |
T10243 |
det |
A,test |
R6821 |
T10243 |
T10245 |
nsubj |
test,require |
R6822 |
T10244 |
T10243 |
amod |
direct,test |
R6823 |
T10246 |
T10243 |
prep |
of,test |
R6824 |
T10247 |
T10248 |
det |
this,link |
R6825 |
T10248 |
T10246 |
pobj |
link,of |
R6826 |
T10249 |
T10245 |
aux |
would,require |
R6827 |
T10250 |
T10251 |
det |
the,measurement |
R6828 |
T10251 |
T10245 |
dobj |
measurement,require |
R6829 |
T10252 |
T10251 |
amod |
quantitative,measurement |
R6830 |
T10253 |
T10251 |
prep |
of,measurement |
R6831 |
T10254 |
T10253 |
pobj |
inhibition,of |
R6832 |
T10255 |
T10254 |
prep |
in,inhibition |
R6833 |
T10256 |
T10257 |
det |
the,preparation |
R6834 |
T10257 |
T10255 |
pobj |
preparation,in |
R6835 |
T10258 |
T10257 |
amod |
intact,preparation |
R6836 |
T10259 |
T10251 |
punct |
", ",measurement |
R6837 |
T10260 |
T10261 |
det |
a,task |
R6838 |
T10261 |
T10251 |
appos |
task,measurement |
R6839 |
T10262 |
T10263 |
dep |
that,be |
R6840 |
T10263 |
T10261 |
relcl |
be,task |
R6841 |
T10264 |
T10263 |
aux |
might,be |
R6842 |
T10265 |
T10263 |
acomp |
feasible,be |
R6843 |
T10266 |
T10265 |
prep |
with,feasible |
R6844 |
T10267 |
T10268 |
advmod |
further,improved |
R6845 |
T10268 |
T10269 |
amod |
improved,techniques |
R6846 |
T10269 |
T10266 |
pobj |
techniques,with |
R6847 |
T10270 |
T10271 |
advmod |
in,vivo |
R6848 |
T10271 |
T10269 |
amod |
vivo,techniques |
R6849 |
T10272 |
T10269 |
amod |
electrophysiological,techniques |
R6850 |
T10273 |
T10269 |
punct |
", ",techniques |
R6851 |
T10274 |
T10275 |
amod |
such,as |
R6852 |
T10275 |
T10269 |
prep |
as,techniques |
R6853 |
T10276 |
T10277 |
amod |
targeted,recordings |
R6854 |
T10277 |
T10275 |
pobj |
recordings,as |
R6855 |
T10278 |
T10279 |
punct |
[,71 |
R6856 |
T10279 |
T10269 |
parataxis |
71,techniques |
R6857 |
T10280 |
T10279 |
nummod |
70,71 |
R6858 |
T10281 |
T10279 |
punct |
",",71 |
R6859 |
T10282 |
T10279 |
punct |
],71 |
R6860 |
T10283 |
T10269 |
cc |
or,techniques |
R6861 |
T10284 |
T10285 |
amod |
simultaneous,measurements |
R6862 |
T10285 |
T10269 |
conj |
measurements,techniques |
R6863 |
T10286 |
T10287 |
advmod |
pre,postsynaptic |
R6864 |
T10287 |
T10285 |
amod |
postsynaptic,measurements |
R6865 |
T10288 |
T10287 |
punct |
-,postsynaptic |
R6866 |
T10289 |
T10287 |
cc |
and,postsynaptic |
R6867 |
T10290 |
T10285 |
amod |
intracellular,measurements |
R6868 |
T10291 |
T10245 |
punct |
.,require |
R6883 |
T10675 |
T10676 |
amod |
Olfactory,Memory |
R6884 |
T10676 |
T10677 |
nsubjpass |
Memory,Reduced |
R6885 |
T10678 |
T10677 |
auxpass |
Is,Reduced |
R6886 |
T10679 |
T10677 |
prep |
in,Reduced |
R6887 |
T10680 |
T10681 |
compound |
GluR,B |
R6888 |
T10681 |
T10683 |
compound |
B,Mice |
R6889 |
T10682 |
T10681 |
punct |
-,B |
R6890 |
T10683 |
T10679 |
pobj |
Mice,in |
R6891 |
T10684 |
T10683 |
compound |
Knockout,Mice |
R6892 |
T10685 |
T10677 |
cc |
and,Reduced |
R6893 |
T10686 |
T10677 |
conj |
Improved,Reduced |
R6894 |
T10687 |
T10686 |
agent |
by,Improved |
R6895 |
T10688 |
T10689 |
compound |
GluR,B |
R6896 |
T10689 |
T10691 |
compound |
B,Expression |
R6897 |
T10690 |
T10689 |
punct |
-,B |
R6898 |
T10691 |
T10687 |
pobj |
Expression,by |
R6899 |
T10692 |
T10686 |
prep |
in,Improved |
R6900 |
T10693 |
T10694 |
amod |
Piriform,Cortex |
R6901 |
T10694 |
T10692 |
pobj |
Cortex,in |
R6902 |
T10695 |
T10694 |
cc |
and,Cortex |
R6903 |
T10696 |
T10694 |
conj |
Hippocampus,Cortex |
R6904 |
T10698 |
T10699 |
aux |
To,assess |
R6905 |
T10699 |
T10700 |
advcl |
assess,probed |
R6906 |
T10701 |
T10702 |
amod |
olfactory,memory |
R6907 |
T10702 |
T10699 |
dobj |
memory,assess |
R6908 |
T10703 |
T10702 |
prep |
of,memory |
R6909 |
T10704 |
T10705 |
compound |
GluR,BΔFB |
R6910 |
T10705 |
T10707 |
compound |
BΔFB,mice |
R6911 |
T10706 |
T10705 |
punct |
-,BΔFB |
R6912 |
T10707 |
T10703 |
pobj |
mice,of |
R6913 |
T10708 |
T10700 |
punct |
", ",probed |
R6914 |
T10709 |
T10700 |
prep |
after,probed |
R6915 |
T10710 |
T10711 |
nummod |
six,days |
R6916 |
T10711 |
T10709 |
pobj |
days,after |
R6917 |
T10712 |
T10713 |
det |
the,mice |
R6918 |
T10713 |
T10700 |
nsubjpass |
mice,probed |
R6919 |
T10714 |
T10700 |
auxpass |
were,probed |
R6920 |
T10715 |
T10700 |
prep |
with,probed |
R6921 |
T10716 |
T10717 |
amod |
unrewarded,presentations |
R6922 |
T10717 |
T10715 |
pobj |
presentations,with |
R6923 |
T10718 |
T10717 |
compound |
odor,presentations |
R6924 |
T10719 |
T10720 |
dep |
that,interleaved |
R6925 |
T10720 |
T10717 |
relcl |
interleaved,presentations |
R6926 |
T10721 |
T10722 |
det |
a,task |
R6927 |
T10722 |
T10720 |
dobj |
task,interleaved |
R6928 |
T10723 |
T10722 |
amod |
simple,task |
R6929 |
T10724 |
T10722 |
compound |
discrimination,task |
R6930 |
T10725 |
T10700 |
punct |
.,probed |
R6931 |
T10727 |
T10728 |
amod |
Prolonged,tasks |
R6932 |
T10728 |
T10730 |
nsubjpass |
tasks,performed |
R6933 |
T10729 |
T10728 |
amod |
behavioral,tasks |
R6934 |
T10731 |
T10732 |
amod |
such,as |
R6935 |
T10732 |
T10728 |
prep |
as,tasks |
R6936 |
T10733 |
T10734 |
det |
the,assessment |
R6937 |
T10734 |
T10732 |
pobj |
assessment,as |
R6938 |
T10735 |
T10734 |
prep |
of,assessment |
R6939 |
T10736 |
T10737 |
amod |
long,term |
R6940 |
T10737 |
T10739 |
nmod |
term,memory |
R6941 |
T10738 |
T10737 |
punct |
-,term |
R6942 |
T10739 |
T10735 |
pobj |
memory,of |
R6943 |
T10740 |
T10739 |
amod |
olfactory,memory |
R6944 |
T10741 |
T10730 |
auxpass |
were,performed |
R6945 |
T10742 |
T10730 |
neg |
not,performed |
R6946 |
T10743 |
T10730 |
prep |
with,performed |
R6947 |
T10744 |
T10745 |
det |
the,mice |
R6948 |
T10745 |
T10743 |
pobj |
mice,with |
R6949 |
T10746 |
T10747 |
npadvmod |
seizure,prone |
R6950 |
T10747 |
T10745 |
amod |
prone,mice |
R6951 |
T10748 |
T10747 |
punct |
-,prone |
R6952 |
T10749 |
T10750 |
nmod |
GluR,BΔECS |
R6953 |
T10750 |
T10745 |
nmod |
BΔECS,mice |
R6954 |
T10751 |
T10750 |
punct |
-,BΔECS |
R6955 |
T10752 |
T10750 |
punct |
:,BΔECS |
R6956 |
T10753 |
T10750 |
appos |
FB,BΔECS |
R6957 |
T10754 |
T10730 |
punct |
.,performed |
R6958 |
T10756 |
T10757 |
nsubjpass |
Memory,impaired |
R6959 |
T10758 |
T10756 |
prep |
in,Memory |
R6960 |
T10759 |
T10760 |
compound |
GluR,BΔFB |
R6961 |
T10760 |
T10762 |
compound |
BΔFB,mice |
R6962 |
T10761 |
T10760 |
punct |
-,BΔFB |
R6963 |
T10762 |
T10758 |
pobj |
mice,in |
R6964 |
T10763 |
T10757 |
punct |
", ",impaired |
R6965 |
T10764 |
T10757 |
advmod |
however,impaired |
R6966 |
T10765 |
T10757 |
punct |
", ",impaired |
R6967 |
T10766 |
T10757 |
auxpass |
was,impaired |
R6968 |
T10767 |
T10757 |
advmod |
dramatically,impaired |
R6969 |
T10768 |
T10757 |
punct |
.,impaired |
R6970 |
T10770 |
T10771 |
nsubjpass |
This,attributed |
R6971 |
T10772 |
T10771 |
aux |
can,attributed |
R6972 |
T10773 |
T10771 |
neg |
not,attributed |
R6973 |
T10774 |
T10771 |
auxpass |
be,attributed |
R6974 |
T10775 |
T10771 |
prep |
to,attributed |
R6975 |
T10776 |
T10777 |
det |
a,deficit |
R6976 |
T10777 |
T10775 |
pobj |
deficit,to |
R6977 |
T10778 |
T10777 |
amod |
general,deficit |
R6978 |
T10779 |
T10777 |
punct |
", ",deficit |
R6979 |
T10780 |
T10777 |
amod |
unspecific,deficit |
R6980 |
T10781 |
T10782 |
mark |
because,performed |
R6981 |
T10782 |
T10771 |
advcl |
performed,attributed |
R6982 |
T10783 |
T10782 |
punct |
", ",performed |
R6983 |
T10784 |
T10782 |
advcl |
simultaneous,performed |
R6984 |
T10785 |
T10784 |
prep |
to,simultaneous |
R6985 |
T10786 |
T10787 |
det |
the,trials |
R6986 |
T10787 |
T10785 |
pobj |
trials,to |
R6987 |
T10788 |
T10787 |
compound |
memory,trials |
R6988 |
T10789 |
T10782 |
punct |
", ",performed |
R6989 |
T10790 |
T10791 |
det |
the,task |
R6990 |
T10791 |
T10782 |
nsubjpass |
task,performed |
R6991 |
T10792 |
T10791 |
amod |
normal,task |
R6992 |
T10793 |
T10791 |
punct |
", ",task |
R6993 |
T10794 |
T10791 |
amod |
rewarded,task |
R6994 |
T10795 |
T10791 |
compound |
discrimination,task |
R6995 |
T10796 |
T10782 |
auxpass |
was,performed |
R6996 |
T10797 |
T10798 |
advmod |
even,better |
R6997 |
T10798 |
T10782 |
advmod |
better,performed |
R6998 |
T10799 |
T10798 |
prep |
than,better |
R6999 |
T10800 |
T10799 |
prep |
by,than |
R7000 |
T10801 |
T10800 |
pobj |
controls,by |
R7001 |
T10802 |
T10771 |
punct |
.,attributed |
R7002 |
T10804 |
T10805 |
amod |
Reduced,memory |
R7003 |
T10805 |
T10807 |
nsubjpass |
memory,attributed |
R7004 |
T10806 |
T10805 |
amod |
olfactory,memory |
R7005 |
T10808 |
T10807 |
aux |
can,attributed |
R7006 |
T10809 |
T10807 |
advmod |
also,attributed |
R7007 |
T10810 |
T10807 |
neg |
not,attributed |
R7008 |
T10811 |
T10807 |
auxpass |
be,attributed |
R7009 |
T10812 |
T10807 |
advmod |
simply,attributed |
R7010 |
T10813 |
T10807 |
prep |
to,attributed |
R7011 |
T10814 |
T10815 |
amod |
increased,extinction |
R7012 |
T10815 |
T10813 |
pobj |
extinction,to |
R7013 |
T10816 |
T10807 |
punct |
", ",attributed |
R7014 |
T10817 |
T10818 |
mark |
as,observed |
R7015 |
T10818 |
T10807 |
advcl |
observed,attributed |
R7016 |
T10819 |
T10820 |
det |
no,interactions |
R7017 |
T10820 |
T10818 |
nsubjpass |
interactions,observed |
R7018 |
T10821 |
T10820 |
amod |
significant,interactions |
R7019 |
T10822 |
T10823 |
compound |
trial,group |
R7020 |
T10823 |
T10820 |
compound |
group,interactions |
R7021 |
T10824 |
T10823 |
punct |
-,group |
R7022 |
T10825 |
T10818 |
auxpass |
were,observed |
R7023 |
T10826 |
T10818 |
cc |
and,observed |
R7024 |
T10827 |
T10828 |
advmod |
also,observed |
R7025 |
T10828 |
T10818 |
conj |
observed,observed |
R7026 |
T10829 |
T10828 |
punct |
", ",observed |
R7027 |
T10830 |
T10831 |
advmod |
when,restricted |
R7028 |
T10831 |
T10828 |
advcl |
restricted,observed |
R7029 |
T10832 |
T10831 |
prep |
to,restricted |
R7030 |
T10833 |
T10834 |
det |
the,trials |
R7031 |
T10834 |
T10832 |
pobj |
trials,to |
R7032 |
T10835 |
T10834 |
amod |
first,trials |
R7033 |
T10836 |
T10834 |
amod |
unrewarded,trials |
R7034 |
T10837 |
T10834 |
compound |
memory,trials |
R7035 |
T10838 |
T10828 |
punct |
", ",observed |
R7036 |
T10839 |
T10840 |
det |
a,impairment |
R7037 |
T10840 |
T10828 |
nsubjpass |
impairment,observed |
R7038 |
T10841 |
T10840 |
amod |
significant,impairment |
R7039 |
T10842 |
T10828 |
auxpass |
was,observed |
R7040 |
T10843 |
T10844 |
punct |
(,S3A |
R7041 |
T10844 |
T10807 |
parataxis |
S3A,attributed |
R7042 |
T10845 |
T10844 |
compound |
Figure,S3A |
R7043 |
T10846 |
T10844 |
punct |
),S3A |
R7044 |
T10847 |
T10807 |
punct |
.,attributed |
R7045 |
T10849 |
T10850 |
advmod |
Additionally,revealed |
R7046 |
T10851 |
T10850 |
punct |
", ",revealed |
R7047 |
T10852 |
T10850 |
csubj |
investigating,revealed |
R7048 |
T10853 |
T10852 |
dobj |
relearning,investigating |
R7049 |
T10854 |
T10853 |
prep |
of,relearning |
R7050 |
T10855 |
T10856 |
det |
the,task |
R7051 |
T10856 |
T10854 |
pobj |
task,of |
R7052 |
T10857 |
T10856 |
amod |
first,task |
R7053 |
T10858 |
T10856 |
compound |
discrimination,task |
R7054 |
T10859 |
T10860 |
det |
a,correlation |
R7055 |
T10860 |
T10850 |
dobj |
correlation,revealed |
R7056 |
T10861 |
T10860 |
amod |
significant,correlation |
R7057 |
T10862 |
T10860 |
prep |
with,correlation |
R7058 |
T10863 |
T10864 |
det |
the,performance |
R7059 |
T10864 |
T10862 |
pobj |
performance,with |
R7060 |
T10865 |
T10864 |
compound |
memory,performance |
R7061 |
T10866 |
T10850 |
punct |
", ",revealed |
R7062 |
T10867 |
T10850 |
advcl |
showing,revealed |
R7063 |
T10868 |
T10869 |
det |
a,deficit |
R7064 |
T10869 |
T10867 |
dobj |
deficit,showing |
R7065 |
T10870 |
T10869 |
punct |
“,deficit |
R7066 |
T10871 |
T10869 |
nmod |
memory,deficit |
R7067 |
T10872 |
T10869 |
punct |
”,deficit |
R7068 |
T10873 |
T10867 |
prep |
under,showing |
R7069 |
T10874 |
T10875 |
npadvmod |
extinction,free |
R7070 |
T10875 |
T10877 |
amod |
free,conditions |
R7071 |
T10876 |
T10875 |
punct |
-,free |
R7072 |
T10877 |
T10873 |
pobj |
conditions,under |
R7073 |
T10878 |
T10879 |
punct |
(,S3B |
R7074 |
T10879 |
T10867 |
parataxis |
S3B,showing |
R7075 |
T10880 |
T10879 |
compound |
Figure,S3B |
R7076 |
T10881 |
T10879 |
punct |
),S3B |
R7077 |
T10882 |
T10850 |
punct |
.,revealed |
R7078 |
T10884 |
T10885 |
advmod |
Finally,impaired |
R7079 |
T10886 |
T10885 |
punct |
", ",impaired |
R7080 |
T10887 |
T10885 |
prep |
in,impaired |
R7081 |
T10888 |
T10889 |
amod |
other,tasks |
R7082 |
T10889 |
T10887 |
pobj |
tasks,in |
R7083 |
T10890 |
T10891 |
npadvmod |
memory,related |
R7084 |
T10891 |
T10889 |
amod |
related,tasks |
R7085 |
T10892 |
T10891 |
punct |
-,related |
R7086 |
T10893 |
T10889 |
punct |
", ",tasks |
R7087 |
T10894 |
T10895 |
amod |
such,as |
R7088 |
T10895 |
T10889 |
prep |
as,tasks |
R7089 |
T10896 |
T10897 |
det |
a,task |
R7090 |
T10897 |
T10895 |
pobj |
task,as |
R7091 |
T10898 |
T10899 |
npadvmod |
hippocampus,dependent |
R7092 |
T10899 |
T10897 |
amod |
dependent,task |
R7093 |
T10900 |
T10899 |
punct |
-,dependent |
R7094 |
T10901 |
T10902 |
amod |
spatial,reference |
R7095 |
T10902 |
T10897 |
compound |
reference,task |
R7096 |
T10903 |
T10897 |
compound |
memory,task |
R7097 |
T10904 |
T10905 |
punct |
(,S2 |
R7098 |
T10905 |
T10889 |
parataxis |
S2,tasks |
R7099 |
T10906 |
T10905 |
compound |
Figure,S2 |
R7100 |
T10907 |
T10905 |
punct |
),S2 |
R7101 |
T10908 |
T10885 |
punct |
", ",impaired |
R7102 |
T10909 |
T10885 |
nsubjpass |
mice,impaired |
R7103 |
T10910 |
T10909 |
prep |
with,mice |
R7104 |
T10911 |
T10912 |
compound |
GluR,B |
R7105 |
T10912 |
T10914 |
compound |
B,depletion |
R7106 |
T10913 |
T10912 |
punct |
-,B |
R7107 |
T10914 |
T10910 |
pobj |
depletion,with |
R7108 |
T10915 |
T10885 |
auxpass |
were,impaired |
R7109 |
T10916 |
T10885 |
neg |
not,impaired |
R7110 |
T10917 |
T10885 |
prep |
after,impaired |
R7111 |
T10918 |
T10919 |
compound |
task,acquisition |
R7112 |
T10919 |
T10917 |
pobj |
acquisition,after |
R7113 |
T10920 |
T10885 |
punct |
.,impaired |
R7114 |
T10922 |
T10923 |
nsubj |
We,conclude |
R7115 |
T10924 |
T10923 |
advmod |
therefore,conclude |
R7116 |
T10925 |
T10926 |
mark |
that,results |
R7117 |
T10926 |
T10923 |
ccomp |
results,conclude |
R7118 |
T10927 |
T10928 |
npadvmod |
forebrain,specific |
R7119 |
T10928 |
T10930 |
amod |
specific,ablation |
R7120 |
T10929 |
T10928 |
punct |
-,specific |
R7121 |
T10930 |
T10926 |
nsubj |
ablation,results |
R7122 |
T10931 |
T10930 |
prep |
of,ablation |
R7123 |
T10932 |
T10933 |
compound |
GluR,B |
R7124 |
T10933 |
T10931 |
pobj |
B,of |
R7125 |
T10934 |
T10933 |
punct |
-,B |
R7126 |
T10935 |
T10926 |
prep |
in,results |
R7127 |
T10936 |
T10937 |
det |
a,loss |
R7128 |
T10937 |
T10935 |
pobj |
loss,in |
R7129 |
T10938 |
T10937 |
amod |
specific,loss |
R7130 |
T10939 |
T10937 |
prep |
of,loss |
R7131 |
T10940 |
T10941 |
amod |
long,term |
R7132 |
T10941 |
T10943 |
nmod |
term,memory |
R7133 |
T10942 |
T10941 |
punct |
-,term |
R7134 |
T10943 |
T10939 |
pobj |
memory,of |
R7135 |
T10944 |
T10943 |
amod |
olfactory,memory |
R7136 |
T10945 |
T10935 |
cc |
but,in |
R7137 |
T10946 |
T10935 |
punct |
", ",in |
R7138 |
T10947 |
T10948 |
prep |
at,in |
R7139 |
T10948 |
T10935 |
conj |
in,in |
R7140 |
T10949 |
T10950 |
det |
the,time |
R7141 |
T10950 |
T10947 |
pobj |
time,at |
R7142 |
T10951 |
T10950 |
amod |
same,time |
R7143 |
T10952 |
T10948 |
punct |
", ",in |
R7144 |
T10953 |
T10954 |
amod |
enhanced,capabilities |
R7145 |
T10954 |
T10948 |
pobj |
capabilities,in |
R7146 |
T10955 |
T10956 |
nmod |
odor,discrimination |
R7147 |
T10956 |
T10954 |
nmod |
discrimination,capabilities |
R7148 |
T10957 |
T10956 |
cc |
and,discrimination |
R7149 |
T10958 |
T10956 |
conj |
learning,discrimination |
R7150 |
T10959 |
T10923 |
punct |
.,conclude |
R7151 |
T10961 |
T10962 |
aux |
To,dissect |
R7152 |
T10962 |
T10963 |
advcl |
dissect,made |
R7153 |
T10964 |
T10965 |
det |
the,phenotypes |
R7154 |
T10965 |
T10962 |
dobj |
phenotypes,dissect |
R7155 |
T10966 |
T10965 |
nmod |
discrimination,phenotypes |
R7156 |
T10967 |
T10966 |
punct |
", ",discrimination |
R7157 |
T10968 |
T10966 |
conj |
learning,discrimination |
R7158 |
T10969 |
T10968 |
punct |
", ",learning |
R7159 |
T10970 |
T10968 |
cc |
and,learning |
R7160 |
T10971 |
T10968 |
conj |
memory,learning |
R7161 |
T10972 |
T10962 |
punct |
", ",dissect |
R7162 |
T10973 |
T10962 |
cc |
and,dissect |
R7163 |
T10974 |
T10975 |
advmod |
ultimately,identify |
R7164 |
T10975 |
T10962 |
conj |
identify,dissect |
R7165 |
T10976 |
T10977 |
amod |
potential,correlates |
R7166 |
T10977 |
T10975 |
dobj |
correlates,identify |
R7167 |
T10978 |
T10977 |
amod |
cellular,correlates |
R7168 |
T10979 |
T10963 |
punct |
", ",made |
R7169 |
T10980 |
T10963 |
nsubj |
we,made |
R7170 |
T10981 |
T10963 |
dobj |
use,made |
R7171 |
T10982 |
T10963 |
prep |
of,made |
R7172 |
T10983 |
T10984 |
det |
the,expression |
R7173 |
T10984 |
T10982 |
pobj |
expression,of |
R7174 |
T10985 |
T10984 |
amod |
variegated,expression |
R7175 |
T10986 |
T10984 |
compound |
Cre,expression |
R7176 |
T10987 |
T10984 |
prep |
of,expression |
R7177 |
T10988 |
T10989 |
compound |
TgCre4,mice |
R7178 |
T10989 |
T10987 |
pobj |
mice,of |
R7179 |
T10990 |
T10963 |
punct |
.,made |
R7180 |
T10992 |
T10993 |
advmod |
Therefore,determined |
R7181 |
T10994 |
T10993 |
punct |
", ",determined |
R7182 |
T10995 |
T10996 |
amod |
residual,levels |
R7183 |
T10996 |
T10993 |
nsubjpass |
levels,determined |
R7184 |
T10997 |
T10998 |
compound |
GluR,B |
R7185 |
T10998 |
T10996 |
compound |
B,levels |
R7186 |
T10999 |
T10998 |
punct |
-,B |
R7187 |
T11000 |
T10993 |
auxpass |
were,determined |
R7188 |
T11001 |
T10993 |
prep |
from,determined |
R7189 |
T11002 |
T11003 |
det |
each,mouse |
R7190 |
T11003 |
T11001 |
pobj |
mouse,from |
R7191 |
T11004 |
T11005 |
dep |
that,tested |
R7192 |
T11005 |
T11003 |
relcl |
tested,mouse |
R7193 |
T11006 |
T11005 |
aux |
had,tested |
R7194 |
T11007 |
T11005 |
auxpass |
been,tested |
R7195 |
T11008 |
T11005 |
prep |
in,tested |
R7196 |
T11009 |
T11010 |
det |
the,experiments |
R7197 |
T11010 |
T11008 |
pobj |
experiments,in |
R7198 |
T11011 |
T11010 |
amod |
behavioral,experiments |
R7199 |
T11012 |
T10993 |
punct |
", ",determined |
R7200 |
T11013 |
T10993 |
cc |
and,determined |
R7201 |
T11014 |
T11015 |
nsubjpass |
levels,correlated |
R7202 |
T11015 |
T10993 |
conj |
correlated,determined |
R7203 |
T11016 |
T11015 |
auxpass |
were,correlated |
R7204 |
T11017 |
T11015 |
prep |
with,correlated |
R7205 |
T11018 |
T11019 |
nmod |
odor,discrimination |
R7206 |
T11019 |
T11017 |
pobj |
discrimination,with |
R7207 |
T11020 |
T11019 |
nmod |
learning,discrimination |
R7208 |
T11021 |
T11019 |
punct |
", ",discrimination |
R7209 |
T11022 |
T11019 |
punct |
", ",discrimination |
R7210 |
T11023 |
T11019 |
cc |
and,discrimination |
R7211 |
T11024 |
T11025 |
amod |
olfactory,memory |
R7212 |
T11025 |
T11019 |
conj |
memory,discrimination |
R7213 |
T11026 |
T10993 |
punct |
.,determined |
R7214 |
T11028 |
T11029 |
det |
The,correlation |
R7215 |
T11029 |
T11032 |
nsubj |
correlation,suggested |
R7216 |
T11030 |
T11029 |
amod |
significant,correlation |
R7217 |
T11031 |
T11029 |
amod |
direct,correlation |
R7218 |
T11033 |
T11029 |
prep |
between,correlation |
R7219 |
T11034 |
T11035 |
amod |
residual,levels |
R7220 |
T11035 |
T11033 |
pobj |
levels,between |
R7221 |
T11036 |
T11037 |
compound |
GluR,B |
R7222 |
T11037 |
T11035 |
compound |
B,levels |
R7223 |
T11038 |
T11037 |
punct |
-,B |
R7224 |
T11039 |
T11035 |
prep |
in,levels |
R7225 |
T11040 |
T11039 |
pobj |
hippocampus,in |
R7226 |
T11041 |
T11040 |
cc |
and,hippocampus |
R7227 |
T11042 |
T11043 |
amod |
cortical,areas |
R7228 |
T11043 |
T11040 |
conj |
areas,hippocampus |
R7229 |
T11044 |
T11029 |
prep |
with,correlation |
R7230 |
T11045 |
T11046 |
amod |
olfactory,memory |
R7231 |
T11046 |
T11044 |
pobj |
memory,with |
R7232 |
T11047 |
T11048 |
amod |
hippocampal,neurons |
R7233 |
T11048 |
T11032 |
dobj |
neurons,suggested |
R7234 |
T11049 |
T11047 |
cc |
and,hippocampal |
R7235 |
T11050 |
T11049 |
punct |
/,and |
R7236 |
T11051 |
T11049 |
cc |
or,and |
R7237 |
T11052 |
T11047 |
conj |
cortical,hippocampal |
R7238 |
T11053 |
T11032 |
prep |
as,suggested |
R7239 |
T11054 |
T11055 |
amod |
putative,mediators |
R7240 |
T11055 |
T11053 |
pobj |
mediators,as |
R7241 |
T11056 |
T11055 |
prep |
for,mediators |
R7242 |
T11057 |
T11058 |
compound |
odor,memorization |
R7243 |
T11058 |
T11056 |
pobj |
memorization,for |
R7244 |
T11059 |
T11058 |
cc |
and,memorization |
R7245 |
T11060 |
T11059 |
punct |
/,and |
R7246 |
T11061 |
T11059 |
cc |
or,and |
R7247 |
T11062 |
T11058 |
conj |
storage,memorization |
R7248 |
T11063 |
T11032 |
punct |
.,suggested |
R7249 |
T11065 |
T11066 |
det |
No,measure |
R7250 |
T11066 |
T11067 |
nsubj |
measure,correlated |
R7251 |
T11067 |
T11078 |
ccomp |
correlated,was |
R7252 |
T11068 |
T11066 |
prep |
of,measure |
R7253 |
T11069 |
T11068 |
pobj |
discrimination,of |
R7254 |
T11070 |
T11069 |
cc |
and,discrimination |
R7255 |
T11071 |
T11069 |
conj |
learning,discrimination |
R7256 |
T11072 |
T11067 |
punct |
", ",correlated |
R7257 |
T11073 |
T11067 |
prep |
on,correlated |
R7258 |
T11074 |
T11075 |
det |
the,hand |
R7259 |
T11075 |
T11073 |
pobj |
hand,on |
R7260 |
T11076 |
T11075 |
amod |
other,hand |
R7261 |
T11077 |
T11067 |
punct |
", ",correlated |
R7262 |
T11079 |
T11067 |
prep |
with,correlated |
R7263 |
T11080 |
T11081 |
amod |
residual,levels |
R7264 |
T11081 |
T11079 |
pobj |
levels,with |
R7265 |
T11082 |
T11083 |
compound |
GluR,B |
R7266 |
T11083 |
T11081 |
compound |
B,levels |
R7267 |
T11084 |
T11083 |
punct |
-,B |
R7268 |
T11085 |
T11078 |
punct |
;,was |
R7269 |
T11086 |
T11087 |
advmod |
even,reduction |
R7270 |
T11087 |
T11078 |
nsubj |
reduction,was |
R7271 |
T11088 |
T11087 |
det |
the,reduction |
R7272 |
T11089 |
T11087 |
amod |
smallest,reduction |
R7273 |
T11090 |
T11087 |
prep |
in,reduction |
R7274 |
T11091 |
T11092 |
compound |
GluR,B |
R7275 |
T11092 |
T11094 |
compound |
B,levels |
R7276 |
T11093 |
T11092 |
punct |
-,B |
R7277 |
T11094 |
T11090 |
pobj |
levels,in |
R7278 |
T11095 |
T11096 |
punct |
(,% |
R7279 |
T11096 |
T11087 |
parataxis |
%,reduction |
R7280 |
T11097 |
T11098 |
quantmod |
about,20 |
R7281 |
T11098 |
T11096 |
nummod |
20,% |
R7282 |
T11099 |
T11100 |
punct |
–,% |
R7283 |
T11100 |
T11096 |
prep |
%,% |
R7284 |
T11101 |
T11100 |
nummod |
60,% |
R7285 |
T11102 |
T11096 |
punct |
),% |
R7286 |
T11103 |
T11078 |
acomp |
sufficient,was |
R7287 |
T11104 |
T11105 |
aux |
to,establish |
R7288 |
T11105 |
T11103 |
xcomp |
establish,sufficient |
R7289 |
T11106 |
T11105 |
cc |
and,establish |
R7290 |
T11107 |
T11105 |
conj |
saturate,establish |
R7291 |
T11108 |
T11109 |
amod |
enhanced,capabilities |
R7292 |
T11109 |
T11107 |
dobj |
capabilities,saturate |
R7293 |
T11110 |
T11111 |
compound |
odor,discrimination |
R7294 |
T11111 |
T11109 |
compound |
discrimination,capabilities |
R7295 |
T11112 |
T11078 |
punct |
.,was |
R7296 |
T11114 |
T11115 |
advmod |
Together,allows |
R7297 |
T11116 |
T11115 |
punct |
", ",allows |
R7298 |
T11117 |
T11115 |
nsubj |
this,allows |
R7299 |
T11118 |
T11119 |
det |
the,conclusion |
R7300 |
T11119 |
T11115 |
dobj |
conclusion,allows |
R7301 |
T11120 |
T11121 |
mark |
that,mediate |
R7302 |
T11121 |
T11119 |
acl |
mediate,conclusion |
R7303 |
T11122 |
T11123 |
amod |
distinct,mechanisms |
R7304 |
T11123 |
T11121 |
nsubj |
mechanisms,mediate |
R7305 |
T11124 |
T11125 |
compound |
discrimination,learning |
R7306 |
T11125 |
T11121 |
dobj |
learning,mediate |
R7307 |
T11126 |
T11125 |
punct |
/,learning |
R7308 |
T11127 |
T11125 |
cc |
and,learning |
R7309 |
T11128 |
T11125 |
conj |
memory,learning |
R7310 |
T11129 |
T11115 |
punct |
.,allows |
R7311 |
T11131 |
T11132 |
nsubj |
This,is |
R7312 |
T11133 |
T11134 |
advmod |
furthermore,consistent |
R7313 |
T11134 |
T11132 |
acomp |
consistent,is |
R7314 |
T11135 |
T11134 |
prep |
with,consistent |
R7315 |
T11136 |
T11137 |
det |
a,role |
R7316 |
T11137 |
T11135 |
pobj |
role,with |
R7317 |
T11138 |
T11137 |
amod |
prominent,role |
R7318 |
T11139 |
T11137 |
prep |
of,role |
R7319 |
T11140 |
T11141 |
amod |
cortical,areas |
R7320 |
T11141 |
T11139 |
pobj |
areas,of |
R7321 |
T11142 |
T11141 |
cc |
or,areas |
R7322 |
T11143 |
T11141 |
conj |
hippocampus,areas |
R7323 |
T11144 |
T11137 |
prep |
in,role |
R7324 |
T11145 |
T11146 |
amod |
olfactory,memory |
R7325 |
T11146 |
T11144 |
pobj |
memory,in |
R7326 |
T11147 |
T11132 |
punct |
", ",is |
R7327 |
T11148 |
T11149 |
mark |
although,correlated |
R7328 |
T11149 |
T11132 |
advcl |
correlated,is |
R7329 |
T11150 |
T11151 |
compound |
GluR,B |
R7330 |
T11151 |
T11153 |
compound |
B,levels |
R7331 |
T11152 |
T11151 |
punct |
-,B |
R7332 |
T11153 |
T11149 |
nsubjpass |
levels,correlated |
R7333 |
T11154 |
T11153 |
prep |
in,levels |
R7334 |
T11155 |
T11156 |
det |
the,bulb |
R7335 |
T11156 |
T11154 |
pobj |
bulb,in |
R7336 |
T11157 |
T11156 |
amod |
olfactory,bulb |
R7337 |
T11158 |
T11149 |
auxpass |
were,correlated |
R7338 |
T11159 |
T11149 |
advmod |
also,correlated |
R7339 |
T11160 |
T11149 |
advmod |
weakly,correlated |
R7340 |
T11161 |
T11149 |
prep |
with,correlated |
R7341 |
T11162 |
T11163 |
compound |
memory,performance |
R7342 |
T11163 |
T11161 |
pobj |
performance,with |
R7343 |
T11164 |
T11132 |
punct |
.,is |
R7344 |
T11166 |
T11167 |
amod |
Transgenic,expression |
R7345 |
T11167 |
T11168 |
nsubj |
expression,rescued |
R7346 |
T11169 |
T11167 |
prep |
of,expression |
R7347 |
T11170 |
T11171 |
compound |
GFPGluR,B |
R7348 |
T11171 |
T11169 |
pobj |
B,of |
R7349 |
T11172 |
T11171 |
punct |
-,B |
R7350 |
T11173 |
T11167 |
prep |
in,expression |
R7351 |
T11174 |
T11175 |
amod |
piriform,cortex |
R7352 |
T11175 |
T11173 |
pobj |
cortex,in |
R7353 |
T11176 |
T11175 |
cc |
and,cortex |
R7354 |
T11177 |
T11175 |
conj |
hippocampus,cortex |
R7355 |
T11178 |
T11168 |
advmod |
indeed,rescued |
R7356 |
T11179 |
T11168 |
dobj |
memory,rescued |
R7357 |
T11180 |
T11168 |
prep |
to,rescued |
R7358 |
T11181 |
T11182 |
det |
an,extent |
R7359 |
T11182 |
T11180 |
pobj |
extent,to |
R7360 |
T11183 |
T11184 |
advmod |
strikingly,consistent |
R7361 |
T11184 |
T11182 |
amod |
consistent,extent |
R7362 |
T11185 |
T11184 |
prep |
with,consistent |
R7363 |
T11186 |
T11187 |
det |
the,levels |
R7364 |
T11187 |
T11185 |
pobj |
levels,with |
R7365 |
T11188 |
T11187 |
amod |
transgenic,levels |
R7366 |
T11189 |
T11187 |
compound |
protein,levels |
R7367 |
T11190 |
T11191 |
punct |
(,% |
R7368 |
T11191 |
T11182 |
parataxis |
%,extent |
R7369 |
T11192 |
T11193 |
advmod |
approximately,10 |
R7370 |
T11193 |
T11191 |
nummod |
10,% |
R7371 |
T11194 |
T11191 |
prep |
of,% |
R7372 |
T11195 |
T11196 |
amod |
wild,type |
R7373 |
T11196 |
T11198 |
compound |
type,B |
R7374 |
T11197 |
T11196 |
punct |
-,type |
R7375 |
T11198 |
T11194 |
pobj |
B,of |
R7376 |
T11199 |
T11198 |
compound |
GluR,B |
R7377 |
T11200 |
T11198 |
punct |
-,B |
R7378 |
T11201 |
T11191 |
punct |
),% |
R7379 |
T11202 |
T11168 |
punct |
", ",rescued |
R7380 |
T11203 |
T11168 |
advcl |
confirming,rescued |
R7381 |
T11204 |
T11205 |
det |
the,reliability |
R7382 |
T11205 |
T11203 |
dobj |
reliability,confirming |
R7383 |
T11206 |
T11205 |
prep |
of,reliability |
R7384 |
T11207 |
T11208 |
det |
the,analysis |
R7385 |
T11208 |
T11206 |
pobj |
analysis,of |
R7386 |
T11209 |
T11208 |
compound |
correlation,analysis |
R7387 |
T11210 |
T11205 |
cc |
and,reliability |
R7388 |
T11211 |
T11212 |
det |
the,sensitivity |
R7389 |
T11212 |
T11205 |
conj |
sensitivity,reliability |
R7390 |
T11213 |
T11212 |
prep |
of,sensitivity |
R7391 |
T11214 |
T11215 |
det |
the,assay |
R7392 |
T11215 |
T11213 |
pobj |
assay,of |
R7393 |
T11216 |
T11215 |
amod |
behavioral,assay |
R7394 |
T11217 |
T11168 |
punct |
.,rescued |
R7395 |
T11219 |
T11220 |
prep |
In,thought |
R7396 |
T11221 |
T11219 |
amod |
general,In |
R7397 |
T11222 |
T11220 |
punct |
", ",thought |
R7398 |
T11223 |
T11224 |
det |
the,hippocampus |
R7399 |
T11224 |
T11220 |
nsubjpass |
hippocampus,thought |
R7400 |
T11225 |
T11220 |
auxpass |
is,thought |
R7401 |
T11226 |
T11227 |
aux |
to,involved |
R7402 |
T11227 |
T11220 |
xcomp |
involved,thought |
R7403 |
T11228 |
T11227 |
auxpass |
be,involved |
R7404 |
T11229 |
T11227 |
prep |
in,involved |
R7405 |
T11230 |
T11231 |
advmod |
only,tasks |
R7406 |
T11231 |
T11229 |
pobj |
tasks,in |
R7407 |
T11232 |
T11231 |
det |
those,tasks |
R7408 |
T11233 |
T11234 |
amod |
olfactory,memory |
R7409 |
T11234 |
T11231 |
compound |
memory,tasks |
R7410 |
T11235 |
T11236 |
dep |
that,involve |
R7411 |
T11236 |
T11231 |
relcl |
involve,tasks |
R7412 |
T11237 |
T11238 |
amod |
temporal,sequence |
R7413 |
T11238 |
T11239 |
compound |
sequence,analysis |
R7414 |
T11239 |
T11236 |
dobj |
analysis,involve |
R7415 |
T11240 |
T11236 |
cc |
or,involve |
R7416 |
T11241 |
T11236 |
conj |
require,involve |
R7417 |
T11242 |
T11243 |
amod |
other,features |
R7418 |
T11243 |
T11241 |
dobj |
features,require |
R7419 |
T11244 |
T11245 |
amod |
higher,cognitive |
R7420 |
T11245 |
T11243 |
amod |
cognitive,features |
R7421 |
T11246 |
T11247 |
punct |
[,2 |
R7422 |
T11247 |
T11220 |
parataxis |
2,thought |
R7423 |
T11248 |
T11247 |
punct |
",",2 |
R7424 |
T11249 |
T11247 |
appos |
13,2 |
R7425 |
T11250 |
T11247 |
punct |
",",2 |
R7426 |
T11251 |
T11247 |
appos |
72,2 |
R7427 |
T11252 |
T11253 |
punct |
–,74 |
R7428 |
T11253 |
T11251 |
prep |
74,72 |
R7429 |
T11254 |
T11247 |
punct |
],2 |
R7430 |
T11255 |
T11220 |
punct |
.,thought |
R7431 |
T11257 |
T11258 |
prep |
In,interfere |
R7432 |
T11259 |
T11257 |
amod |
particular,In |
R7433 |
T11260 |
T11258 |
punct |
", ",interfere |
R7434 |
T11261 |
T11262 |
amod |
extensive,lesions |
R7435 |
T11262 |
T11258 |
nsubj |
lesions,interfere |
R7436 |
T11263 |
T11262 |
prep |
to,lesions |
R7437 |
T11264 |
T11265 |
det |
the,formation |
R7438 |
T11265 |
T11263 |
pobj |
formation,to |
R7439 |
T11266 |
T11265 |
amod |
hippocampal,formation |
R7440 |
T11267 |
T11262 |
prep |
in,lesions |
R7441 |
T11268 |
T11267 |
pobj |
rats,in |
R7442 |
T11269 |
T11258 |
aux |
do,interfere |
R7443 |
T11270 |
T11258 |
neg |
not,interfere |
R7444 |
T11271 |
T11258 |
prep |
with,interfere |
R7445 |
T11272 |
T11273 |
amod |
long,term |
R7446 |
T11273 |
T11275 |
nmod |
term,memory |
R7447 |
T11274 |
T11273 |
punct |
-,term |
R7448 |
T11275 |
T11271 |
pobj |
memory,with |
R7449 |
T11276 |
T11275 |
amod |
olfactory,memory |
R7450 |
T11277 |
T11258 |
prep |
in,interfere |
R7451 |
T11278 |
T11279 |
nmod |
go,tasks |
R7452 |
T11279 |
T11277 |
pobj |
tasks,in |
R7453 |
T11280 |
T11278 |
punct |
/,go |
R7454 |
T11281 |
T11282 |
det |
no,go |
R7455 |
T11282 |
T11278 |
appos |
go,go |
R7456 |
T11283 |
T11282 |
punct |
-,go |
R7457 |
T11284 |
T11279 |
amod |
successive,tasks |
R7458 |
T11285 |
T11286 |
amod |
olfactory,discrimination |
R7459 |
T11286 |
T11279 |
compound |
discrimination,tasks |
R7460 |
T11287 |
T11288 |
punct |
[,72 |
R7461 |
T11288 |
T11279 |
parataxis |
72,tasks |
R7462 |
T11289 |
T11288 |
punct |
],72 |
R7463 |
T11290 |
T11279 |
punct |
", ",tasks |
R7464 |
T11291 |
T11292 |
amod |
such,as |
R7465 |
T11292 |
T11279 |
prep |
as,tasks |
R7466 |
T11293 |
T11294 |
det |
the,one |
R7467 |
T11294 |
T11292 |
pobj |
one,as |
R7468 |
T11295 |
T11294 |
acl |
described,one |
R7469 |
T11296 |
T11258 |
punct |
.,interfere |
R7470 |
T11298 |
T11299 |
nsubj |
This,leaves |
R7471 |
T11300 |
T11301 |
amod |
piriform,cortex |
R7472 |
T11301 |
T11299 |
dobj |
cortex,leaves |
R7473 |
T11302 |
T11299 |
prep |
as,leaves |
R7474 |
T11303 |
T11304 |
det |
the,candidate |
R7475 |
T11304 |
T11302 |
pobj |
candidate,as |
R7476 |
T11305 |
T11306 |
advmod |
most,prominent |
R7477 |
T11306 |
T11304 |
amod |
prominent,candidate |
R7478 |
T11307 |
T11304 |
prep |
for,candidate |
R7479 |
T11308 |
T11309 |
det |
the,locus |
R7480 |
T11309 |
T11307 |
pobj |
locus,for |
R7481 |
T11310 |
T11309 |
prep |
of,locus |
R7482 |
T11311 |
T11312 |
det |
the,deficit |
R7483 |
T11312 |
T11310 |
pobj |
deficit,of |
R7484 |
T11313 |
T11314 |
amod |
olfactory,memory |
R7485 |
T11314 |
T11312 |
compound |
memory,deficit |
R7486 |
T11315 |
T11312 |
acl |
described,deficit |
R7487 |
T11316 |
T11299 |
punct |
", ",leaves |
R7488 |
T11317 |
T11299 |
advcl |
consistent,leaves |
R7489 |
T11318 |
T11317 |
prep |
with,consistent |
R7490 |
T11319 |
T11320 |
det |
the,view |
R7491 |
T11320 |
T11318 |
pobj |
view,with |
R7492 |
T11321 |
T11320 |
amod |
prevalent,view |
R7493 |
T11322 |
T11320 |
prep |
of,view |
R7494 |
T11323 |
T11324 |
amod |
piriform,cortex |
R7495 |
T11324 |
T11322 |
pobj |
cortex,of |
R7496 |
T11325 |
T11320 |
prep |
as,view |
R7497 |
T11326 |
T11327 |
det |
an,structure |
R7498 |
T11327 |
T11325 |
pobj |
structure,as |
R7499 |
T11328 |
T11329 |
amod |
associational,memory |
R7500 |
T11329 |
T11327 |
compound |
memory,structure |
R7501 |
T11330 |
T11331 |
punct |
[,75 |
R7502 |
T11331 |
T11320 |
parataxis |
75,view |
R7503 |
T11332 |
T11331 |
punct |
],75 |
R7504 |
T11333 |
T11320 |
cc |
and,view |
R7505 |
T11334 |
T11335 |
npadvmod |
learning,associated |
R7506 |
T11335 |
T11337 |
amod |
associated,changes |
R7507 |
T11336 |
T11335 |
punct |
-,associated |
R7508 |
T11337 |
T11320 |
conj |
changes,view |
R7509 |
T11338 |
T11337 |
prep |
in,changes |
R7510 |
T11339 |
T11340 |
amod |
piriform,cortex |
R7511 |
T11340 |
T11338 |
pobj |
cortex,in |
R7512 |
T11341 |
T11342 |
punct |
[,7 |
R7513 |
T11342 |
T11337 |
parataxis |
7,changes |
R7514 |
T11343 |
T11342 |
punct |
",",7 |
R7515 |
T11344 |
T11342 |
appos |
20,7 |
R7516 |
T11345 |
T11346 |
punct |
–,23 |
R7517 |
T11346 |
T11344 |
prep |
23,20 |
R7518 |
T11347 |
T11342 |
punct |
],7 |
R7519 |
T11348 |
T11299 |
punct |
.,leaves |
R7530 |
T11632 |
T11633 |
amod |
Potential,Mechanisms |
R7531 |
T11634 |
T11633 |
prep |
of,Mechanisms |
R7532 |
T11635 |
T11636 |
amod |
Specific,Impairment |
R7533 |
T11636 |
T11634 |
pobj |
Impairment,of |
R7534 |
T11637 |
T11638 |
amod |
Olfactory,Memory |
R7535 |
T11638 |
T11636 |
compound |
Memory,Impairment |
R7536 |
T11640 |
T11641 |
dep |
What,be |
R7537 |
T11642 |
T11641 |
aux |
could,be |
R7538 |
T11643 |
T11644 |
det |
the,basis |
R7539 |
T11644 |
T11641 |
attr |
basis,be |
R7540 |
T11645 |
T11644 |
amod |
cellular,basis |
R7541 |
T11646 |
T11644 |
prep |
of,basis |
R7542 |
T11647 |
T11648 |
det |
the,deficit |
R7543 |
T11648 |
T11646 |
pobj |
deficit,of |
R7544 |
T11649 |
T11650 |
amod |
long,term |
R7545 |
T11650 |
T11648 |
compound |
term,deficit |
R7546 |
T11651 |
T11650 |
punct |
-,term |
R7547 |
T11652 |
T11648 |
compound |
memory,deficit |
R7548 |
T11653 |
T11648 |
acl |
brought,deficit |
R7549 |
T11654 |
T11653 |
prt |
about,brought |
R7550 |
T11655 |
T11653 |
agent |
by,brought |
R7551 |
T11656 |
T11655 |
pobj |
lack,by |
R7552 |
T11657 |
T11656 |
prep |
of,lack |
R7553 |
T11658 |
T11659 |
compound |
GluR,B |
R7554 |
T11659 |
T11661 |
npadvmod |
B,containing |
R7555 |
T11660 |
T11659 |
punct |
-,B |
R7556 |
T11661 |
T11663 |
amod |
containing,AMPARs |
R7557 |
T11662 |
T11661 |
punct |
-,containing |
R7558 |
T11663 |
T11657 |
pobj |
AMPARs,of |
R7559 |
T11664 |
T11641 |
punct |
?,be |
R7560 |
T11666 |
T11667 |
prep |
For,reported |
R7561 |
T11668 |
T11669 |
amod |
complete,knockouts |
R7562 |
T11669 |
T11666 |
pobj |
knockouts,For |
R7563 |
T11670 |
T11671 |
compound |
GluR,B |
R7564 |
T11671 |
T11669 |
compound |
B,knockouts |
R7565 |
T11672 |
T11671 |
punct |
-,B |
R7566 |
T11673 |
T11667 |
punct |
", ",reported |
R7567 |
T11674 |
T11675 |
amod |
increased,plasticity |
R7568 |
T11675 |
T11667 |
nsubjpass |
plasticity,reported |
R7569 |
T11676 |
T11677 |
amod |
long,term |
R7570 |
T11677 |
T11675 |
compound |
term,plasticity |
R7571 |
T11678 |
T11677 |
punct |
-,term |
R7572 |
T11679 |
T11675 |
punct |
(,plasticity |
R7573 |
T11680 |
T11675 |
appos |
LTP,plasticity |
R7574 |
T11681 |
T11667 |
punct |
),reported |
R7575 |
T11682 |
T11667 |
auxpass |
was,reported |
R7576 |
T11683 |
T11667 |
prep |
in,reported |
R7577 |
T11684 |
T11685 |
amod |
hippocampal,recordings |
R7578 |
T11685 |
T11683 |
pobj |
recordings,in |
R7579 |
T11686 |
T11685 |
compound |
field,recordings |
R7580 |
T11687 |
T11688 |
punct |
[,51 |
R7581 |
T11688 |
T11667 |
parataxis |
51,reported |
R7582 |
T11689 |
T11688 |
punct |
],51 |
R7583 |
T11690 |
T11667 |
punct |
.,reported |
R7584 |
T11692 |
T11693 |
prep |
In,induced |
R7585 |
T11694 |
T11692 |
pobj |
addition,In |
R7586 |
T11695 |
T11693 |
punct |
", ",induced |
R7587 |
T11696 |
T11693 |
prep |
in,induced |
R7588 |
T11697 |
T11698 |
amod |
hippocampal,pathways |
R7589 |
T11698 |
T11696 |
pobj |
pathways,in |
R7590 |
T11699 |
T11697 |
cc |
and,hippocampal |
R7591 |
T11700 |
T11697 |
conj |
amygdala,hippocampal |
R7592 |
T11701 |
T11698 |
acl |
lacking,pathways |
R7593 |
T11702 |
T11703 |
compound |
GluR,B |
R7594 |
T11703 |
T11701 |
dobj |
B,lacking |
R7595 |
T11704 |
T11703 |
punct |
-,B |
R7596 |
T11705 |
T11693 |
punct |
", ",induced |
R7597 |
T11706 |
T11707 |
det |
an,form |
R7598 |
T11707 |
T11693 |
nsubjpass |
form,induced |
R7599 |
T11708 |
T11709 |
npadvmod |
AMPAR,dependent |
R7600 |
T11709 |
T11707 |
amod |
dependent,form |
R7601 |
T11710 |
T11709 |
punct |
-,dependent |
R7602 |
T11711 |
T11707 |
punct |
", ",form |
R7603 |
T11712 |
T11713 |
nmod |
N,aspartate |
R7604 |
T11713 |
T11707 |
nmod |
aspartate,form |
R7605 |
T11714 |
T11713 |
punct |
-,aspartate |
R7606 |
T11715 |
T11713 |
nmod |
methyl,aspartate |
R7607 |
T11716 |
T11713 |
punct |
-,aspartate |
R7608 |
T11717 |
T11713 |
nmod |
D,aspartate |
R7609 |
T11718 |
T11713 |
punct |
-,aspartate |
R7610 |
T11719 |
T11713 |
punct |
(,aspartate |
R7611 |
T11720 |
T11713 |
appos |
NMDA,aspartate |
R7612 |
T11721 |
T11707 |
punct |
),form |
R7613 |
T11722 |
T11723 |
npadvmod |
receptor,independent |
R7614 |
T11723 |
T11707 |
amod |
independent,form |
R7615 |
T11724 |
T11723 |
punct |
-,independent |
R7616 |
T11725 |
T11707 |
prep |
of,form |
R7617 |
T11726 |
T11725 |
pobj |
LTP,of |
R7618 |
T11727 |
T11693 |
aux |
can,induced |
R7619 |
T11728 |
T11693 |
auxpass |
be,induced |
R7620 |
T11729 |
T11693 |
advmod |
readily,induced |
R7621 |
T11730 |
T11731 |
punct |
[,52 |
R7622 |
T11731 |
T11693 |
parataxis |
52,induced |
R7623 |
T11732 |
T11731 |
nummod |
51,52 |
R7624 |
T11733 |
T11731 |
punct |
",",52 |
R7625 |
T11734 |
T11731 |
punct |
],52 |
R7626 |
T11735 |
T11693 |
punct |
.,induced |
R7627 |
T11737 |
T11738 |
advmod |
Mechanistically,is |
R7628 |
T11739 |
T11738 |
punct |
", ",is |
R7629 |
T11740 |
T11738 |
nsubj |
this,is |
R7630 |
T11741 |
T11738 |
acomp |
likely,is |
R7631 |
T11742 |
T11743 |
aux |
to,be |
R7632 |
T11743 |
T11741 |
xcomp |
be,likely |
R7633 |
T11744 |
T11743 |
prep |
due,be |
R7634 |
T11745 |
T11744 |
pcomp |
to,due |
R7635 |
T11746 |
T11747 |
nmod |
Ca2,influx |
R7636 |
T11747 |
T11744 |
pobj |
influx,due |
R7637 |
T11748 |
T11746 |
punct |
+,Ca2 |
R7638 |
T11749 |
T11747 |
prep |
through,influx |
R7639 |
T11750 |
T11751 |
compound |
GluR,B |
R7640 |
T11751 |
T11753 |
npadvmod |
B,less |
R7641 |
T11752 |
T11751 |
punct |
-,B |
R7642 |
T11753 |
T11755 |
amod |
less,channels |
R7643 |
T11754 |
T11753 |
punct |
-,less |
R7644 |
T11755 |
T11749 |
pobj |
channels,through |
R7645 |
T11756 |
T11755 |
compound |
AMPA,channels |
R7646 |
T11757 |
T11743 |
advcl |
leading,be |
R7647 |
T11758 |
T11757 |
prep |
to,leading |
R7648 |
T11759 |
T11760 |
amod |
non-hebbian,forms |
R7649 |
T11760 |
T11758 |
pobj |
forms,to |
R7650 |
T11761 |
T11760 |
prep |
of,forms |
R7651 |
T11762 |
T11761 |
pobj |
plasticity,of |
R7652 |
T11763 |
T11738 |
punct |
.,is |
R7653 |
T11765 |
T11766 |
advmod |
However,is |
R7654 |
T11766 |
T11777 |
ccomp |
is,result |
R7655 |
T11767 |
T11766 |
punct |
", ",is |
R7656 |
T11768 |
T11769 |
amod |
hebbian,dependence |
R7657 |
T11769 |
T11766 |
nsubj |
dependence,is |
R7658 |
T11770 |
T11769 |
prep |
on,dependence |
R7659 |
T11771 |
T11772 |
amod |
simultaneous,activity |
R7660 |
T11772 |
T11770 |
pobj |
activity,on |
R7661 |
T11773 |
T11774 |
advmod |
pre,postsynaptic |
R7662 |
T11774 |
T11772 |
amod |
postsynaptic,activity |
R7663 |
T11775 |
T11774 |
punct |
-,postsynaptic |
R7664 |
T11776 |
T11774 |
cc |
and,postsynaptic |
R7665 |
T11778 |
T11766 |
advmod |
often,is |
R7666 |
T11779 |
T11780 |
det |
a,feature |
R7667 |
T11780 |
T11766 |
attr |
feature,is |
R7668 |
T11781 |
T11780 |
amod |
critical,feature |
R7669 |
T11782 |
T11780 |
prep |
for,feature |
R7670 |
T11783 |
T11784 |
compound |
memory,storage |
R7671 |
T11784 |
T11782 |
pobj |
storage,for |
R7672 |
T11785 |
T11786 |
punct |
(,reviewed |
R7673 |
T11786 |
T11766 |
parataxis |
reviewed,is |
R7674 |
T11787 |
T11786 |
prep |
in,reviewed |
R7675 |
T11788 |
T11789 |
advmod |
e.g.,76 |
R7676 |
T11789 |
T11787 |
pobj |
76,in |
R7677 |
T11790 |
T11789 |
punct |
[,76 |
R7678 |
T11791 |
T11787 |
punct |
],in |
R7679 |
T11792 |
T11786 |
punct |
),reviewed |
R7680 |
T11793 |
T11777 |
punct |
;,result |
R7681 |
T11794 |
T11777 |
advmod |
hence,result |
R7682 |
T11795 |
T11777 |
punct |
", ",result |
R7683 |
T11796 |
T11797 |
det |
a,form |
R7684 |
T11797 |
T11777 |
nsubj |
form,result |
R7685 |
T11798 |
T11797 |
amod |
non-hebbian,form |
R7686 |
T11799 |
T11797 |
prep |
of,form |
R7687 |
T11800 |
T11799 |
pobj |
plasticity,of |
R7688 |
T11801 |
T11777 |
aux |
should,result |
R7689 |
T11802 |
T11777 |
prep |
in,result |
R7690 |
T11803 |
T11804 |
amod |
impaired,memorization |
R7691 |
T11804 |
T11802 |
pobj |
memorization,in |
R7692 |
T11805 |
T11777 |
punct |
.,result |
R7693 |
T11807 |
T11808 |
advmod |
Surprisingly,observed |
R7694 |
T11809 |
T11808 |
punct |
", ",observed |
R7695 |
T11810 |
T11808 |
prep |
in,observed |
R7696 |
T11811 |
T11812 |
compound |
GluR,BΔFB |
R7697 |
T11812 |
T11814 |
compound |
BΔFB,mice |
R7698 |
T11813 |
T11812 |
punct |
-,BΔFB |
R7699 |
T11814 |
T11810 |
pobj |
mice,in |
R7700 |
T11815 |
T11816 |
det |
no,changes |
R7701 |
T11816 |
T11808 |
nsubjpass |
changes,observed |
R7702 |
T11817 |
T11816 |
compound |
LTP,changes |
R7703 |
T11818 |
T11808 |
aux |
could,observed |
R7704 |
T11819 |
T11808 |
auxpass |
be,observed |
R7705 |
T11820 |
T11808 |
prep |
in,observed |
R7706 |
T11821 |
T11822 |
compound |
field,measurements |
R7707 |
T11822 |
T11820 |
pobj |
measurements,in |
R7708 |
T11823 |
T11808 |
prep |
in,observed |
R7709 |
T11824 |
T11825 |
det |
the,hippocampus |
R7710 |
T11825 |
T11823 |
pobj |
hippocampus,in |
R7711 |
T11826 |
T11808 |
punct |
", ",observed |
R7712 |
T11827 |
T11808 |
cc |
nor,observed |
R7713 |
T11828 |
T11829 |
aux |
could,induced |
R7714 |
T11829 |
T11808 |
conj |
induced,observed |
R7715 |
T11830 |
T11831 |
npadvmod |
NMDA,independent |
R7716 |
T11831 |
T11833 |
amod |
independent,LTP |
R7717 |
T11832 |
T11831 |
punct |
-,independent |
R7718 |
T11833 |
T11829 |
nsubjpass |
LTP,induced |
R7719 |
T11834 |
T11829 |
auxpass |
be,induced |
R7720 |
T11835 |
T11829 |
prep |
in,induced |
R7721 |
T11836 |
T11837 |
amod |
hippocampal,synapses |
R7722 |
T11837 |
T11835 |
pobj |
synapses,in |
R7723 |
T11838 |
T11837 |
prep |
between,synapses |
R7724 |
T11839 |
T11840 |
compound |
Schaffer,collaterals |
R7725 |
T11840 |
T11838 |
pobj |
collaterals,between |
R7726 |
T11841 |
T11840 |
cc |
and,collaterals |
R7727 |
T11842 |
T11843 |
nmod |
CA1,cells |
R7728 |
T11843 |
T11840 |
conj |
cells,collaterals |
R7729 |
T11844 |
T11843 |
amod |
pyramidal,cells |
R7730 |
T11845 |
T11829 |
prep |
in,induced |
R7731 |
T11846 |
T11845 |
pobj |
presence,in |
R7732 |
T11847 |
T11846 |
prep |
of,presence |
R7733 |
T11848 |
T11849 |
det |
the,antagonist |
R7734 |
T11849 |
T11847 |
pobj |
antagonist,of |
R7735 |
T11850 |
T11849 |
compound |
NMDA,antagonist |
R7736 |
T11851 |
T11849 |
appos |
APV,antagonist |
R7737 |
T11852 |
T11853 |
punct |
(,K. |
R7738 |
T11853 |
T11829 |
meta |
K.,induced |
R7739 |
T11854 |
T11853 |
nmod |
Jensen,K. |
R7740 |
T11855 |
T11853 |
punct |
", ",K. |
R7741 |
T11856 |
T11853 |
nmod |
O.,K. |
R7742 |
T11857 |
T11853 |
nmod |
Hvalby,K. |
R7743 |
T11858 |
T11853 |
punct |
", ",K. |
R7744 |
T11859 |
T11853 |
amod |
personal,K. |
R7745 |
T11860 |
T11853 |
nmod |
communication,K. |
R7746 |
T11861 |
T11853 |
punct |
),K. |
R7747 |
T11862 |
T11829 |
punct |
.,induced |
R7748 |
T11864 |
T11865 |
advmod |
However,performed |
R7749 |
T11865 |
T11896 |
ccomp |
performed,regulated |
R7750 |
T11866 |
T11865 |
punct |
", ",performed |
R7751 |
T11867 |
T11865 |
prep |
in,performed |
R7752 |
T11868 |
T11869 |
amod |
other,areas |
R7753 |
T11869 |
T11867 |
pobj |
areas,in |
R7754 |
T11870 |
T11869 |
compound |
brain,areas |
R7755 |
T11871 |
T11872 |
dep |
that,are |
R7756 |
T11872 |
T11869 |
relcl |
are,areas |
R7757 |
T11873 |
T11874 |
advmod |
potentially,important |
R7758 |
T11874 |
T11872 |
acomp |
important,are |
R7759 |
T11875 |
T11874 |
prep |
for,important |
R7760 |
T11876 |
T11877 |
det |
the,processing |
R7761 |
T11877 |
T11875 |
pobj |
processing,for |
R7762 |
T11878 |
T11877 |
prep |
of,processing |
R7763 |
T11879 |
T11880 |
amod |
olfactory,information |
R7764 |
T11880 |
T11878 |
pobj |
information,of |
R7765 |
T11881 |
T11869 |
punct |
", ",areas |
R7766 |
T11882 |
T11883 |
amod |
such,as |
R7767 |
T11883 |
T11869 |
prep |
as,areas |
R7768 |
T11884 |
T11885 |
amod |
piriform,cortex |
R7769 |
T11885 |
T11883 |
pobj |
cortex,as |
R7770 |
T11886 |
T11885 |
cc |
or,cortex |
R7771 |
T11887 |
T11888 |
amod |
olfactory,bulb |
R7772 |
T11888 |
T11885 |
conj |
bulb,cortex |
R7773 |
T11889 |
T11865 |
punct |
", ",performed |
R7774 |
T11890 |
T11891 |
compound |
LTP,measurements |
R7775 |
T11891 |
T11865 |
nsubjpass |
measurements,performed |
R7776 |
T11892 |
T11865 |
aux |
have,performed |
R7777 |
T11893 |
T11865 |
neg |
not,performed |
R7778 |
T11894 |
T11865 |
advmod |
yet,performed |
R7779 |
T11895 |
T11865 |
auxpass |
been,performed |
R7780 |
T11897 |
T11896 |
punct |
;,regulated |
R7781 |
T11898 |
T11896 |
nsubjpass |
synapses,regulated |
R7782 |
T11899 |
T11898 |
prep |
of,synapses |
R7783 |
T11900 |
T11901 |
det |
these,pathways |
R7784 |
T11901 |
T11899 |
pobj |
pathways,of |
R7785 |
T11902 |
T11896 |
aux |
may,regulated |
R7786 |
T11903 |
T11896 |
auxpass |
be,regulated |
R7787 |
T11904 |
T11896 |
advmod |
differently,regulated |
R7788 |
T11905 |
T11904 |
prep |
than,differently |
R7789 |
T11906 |
T11907 |
amod |
hippocampal,synapses |
R7790 |
T11907 |
T11905 |
pobj |
synapses,than |
R7791 |
T11908 |
T11909 |
compound |
CA3,CA1 |
R7792 |
T11909 |
T11907 |
compound |
CA1,synapses |
R7793 |
T11910 |
T11909 |
punct |
/,CA1 |
R7794 |
T11911 |
T11896 |
punct |
.,regulated |
R7795 |
T11913 |
T11914 |
advmod |
Additionally,disturbed |
R7796 |
T11915 |
T11914 |
punct |
", ",disturbed |
R7797 |
T11916 |
T11914 |
prep |
by,disturbed |
R7798 |
T11917 |
T11916 |
pcomp |
changing,by |
R7799 |
T11918 |
T11919 |
det |
the,permeability |
R7800 |
T11919 |
T11917 |
dobj |
permeability,changing |
R7801 |
T11920 |
T11919 |
nmod |
Ca2,permeability |
R7802 |
T11921 |
T11920 |
punct |
+,Ca2 |
R7803 |
T11922 |
T11919 |
prep |
of,permeability |
R7804 |
T11923 |
T11922 |
pobj |
AMPARs,of |
R7805 |
T11924 |
T11914 |
punct |
", ",disturbed |
R7806 |
T11925 |
T11926 |
nmod |
Ca2,signaling |
R7807 |
T11926 |
T11914 |
nsubjpass |
signaling,disturbed |
R7808 |
T11927 |
T11925 |
punct |
+,Ca2 |
R7809 |
T11928 |
T11926 |
prep |
via,signaling |
R7810 |
T11929 |
T11930 |
nmod |
AMPA,channels |
R7811 |
T11930 |
T11928 |
pobj |
channels,via |
R7812 |
T11931 |
T11929 |
cc |
and,AMPA |
R7813 |
T11932 |
T11933 |
amod |
colocalized,NMDA |
R7814 |
T11933 |
T11929 |
conj |
NMDA,AMPA |
R7815 |
T11934 |
T11914 |
aux |
might,disturbed |
R7816 |
T11935 |
T11914 |
auxpass |
be,disturbed |
R7817 |
T11936 |
T11914 |
punct |
", ",disturbed |
R7818 |
T11937 |
T11938 |
advmod |
thereby,impairing |
R7819 |
T11938 |
T11914 |
advcl |
impairing,disturbed |
R7820 |
T11939 |
T11940 |
compound |
memory,formation |
R7821 |
T11940 |
T11938 |
dobj |
formation,impairing |
R7822 |
T11941 |
T11914 |
punct |
.,disturbed |
R7823 |
T11943 |
T11944 |
amod |
Other,forms |
R7824 |
T11944 |
T11945 |
nsubj |
forms,play |
R7825 |
T11946 |
T11944 |
prep |
of,forms |
R7826 |
T11947 |
T11946 |
pobj |
plasticity,of |
R7827 |
T11948 |
T11949 |
punct |
[,78 |
R7828 |
T11949 |
T11947 |
parataxis |
78,plasticity |
R7829 |
T11950 |
T11949 |
nummod |
77,78 |
R7830 |
T11951 |
T11949 |
punct |
",",78 |
R7831 |
T11952 |
T11949 |
punct |
],78 |
R7832 |
T11953 |
T11944 |
acl |
induced,forms |
R7833 |
T11954 |
T11953 |
agent |
by,induced |
R7834 |
T11955 |
T11956 |
npadvmod |
Ca2,permeable |
R7835 |
T11956 |
T11959 |
amod |
permeable,AMPARs |
R7836 |
T11957 |
T11955 |
punct |
+,Ca2 |
R7837 |
T11958 |
T11956 |
punct |
-,permeable |
R7838 |
T11959 |
T11954 |
pobj |
AMPARs,by |
R7839 |
T11960 |
T11945 |
aux |
might,play |
R7840 |
T11961 |
T11962 |
det |
a,role |
R7841 |
T11962 |
T11945 |
dobj |
role,play |
R7842 |
T11963 |
T11962 |
amod |
prevalent,role |
R7843 |
T11964 |
T11945 |
prep |
in,play |
R7844 |
T11965 |
T11966 |
amod |
olfactory,memory |
R7845 |
T11966 |
T11964 |
pobj |
memory,in |
R7846 |
T11967 |
T11945 |
punct |
.,play |
R7847 |
T11969 |
T11970 |
advmod |
Alternatively,involve |
R7848 |
T11971 |
T11970 |
punct |
", ",involve |
R7849 |
T11972 |
T11973 |
amod |
long,term |
R7850 |
T11973 |
T11975 |
compound |
term,stabilization |
R7851 |
T11974 |
T11973 |
punct |
-,term |
R7852 |
T11975 |
T11970 |
nsubj |
stabilization,involve |
R7853 |
T11976 |
T11970 |
aux |
might,involve |
R7854 |
T11977 |
T11978 |
compound |
GluR,B |
R7855 |
T11978 |
T11980 |
compound |
B,phosphorylation |
R7856 |
T11979 |
T11978 |
punct |
-,B |
R7857 |
T11980 |
T11970 |
dobj |
phosphorylation,involve |
R7858 |
T11981 |
T11970 |
advcl |
similar,involve |
R7859 |
T11982 |
T11981 |
prep |
to,similar |
R7860 |
T11983 |
T11984 |
amod |
cerebellar,depression |
R7861 |
T11984 |
T11982 |
pobj |
depression,to |
R7862 |
T11985 |
T11986 |
amod |
long,term |
R7863 |
T11986 |
T11984 |
compound |
term,depression |
R7864 |
T11987 |
T11986 |
punct |
-,term |
R7865 |
T11988 |
T11989 |
punct |
[,79 |
R7866 |
T11989 |
T11970 |
parataxis |
79,involve |
R7867 |
T11990 |
T11989 |
punct |
],79 |
R7868 |
T11991 |
T11970 |
cc |
and,involve |
R7869 |
T11992 |
T11993 |
advmod |
thus,impaired |
R7870 |
T11993 |
T11970 |
conj |
impaired,involve |
R7871 |
T11994 |
T11993 |
auxpass |
be,impaired |
R7872 |
T11995 |
T11993 |
advmod |
selectively,impaired |
R7873 |
T11996 |
T11993 |
agent |
by,impaired |
R7874 |
T11997 |
T11998 |
compound |
GluR,B |
R7875 |
T11998 |
T12000 |
compound |
B,depletion |
R7876 |
T11999 |
T11998 |
punct |
-,B |
R7877 |
T12000 |
T11996 |
pobj |
depletion,by |
R7878 |
T12001 |
T11970 |
punct |
.,involve |
R7879 |
T12003 |
T12004 |
amod |
Physiological,experiments |
R7880 |
T12004 |
T12005 |
nsubj |
experiments,make |
R7881 |
T12006 |
T12007 |
aux |
to,assess |
R7882 |
T12007 |
T12004 |
advcl |
assess,experiments |
R7883 |
T12008 |
T12009 |
det |
these,hypotheses |
R7884 |
T12009 |
T12007 |
dobj |
hypotheses,assess |
R7885 |
T12010 |
T12005 |
aux |
will,make |
R7886 |
T12011 |
T12005 |
advmod |
ideally,make |
R7887 |
T12012 |
T12005 |
dobj |
use,make |
R7888 |
T12013 |
T12005 |
prep |
of,make |
R7889 |
T12014 |
T12015 |
advmod |
even,more |
R7890 |
T12015 |
T12016 |
advmod |
more,restricted |
R7891 |
T12016 |
T12017 |
amod |
restricted,modifications |
R7892 |
T12017 |
T12013 |
pobj |
modifications,of |
R7893 |
T12018 |
T12017 |
amod |
genetic,modifications |
R7894 |
T12019 |
T12017 |
prep |
with,modifications |
R7895 |
T12020 |
T12021 |
advmod |
completely,undisturbed |
R7896 |
T12021 |
T12022 |
amod |
undisturbed,structures |
R7897 |
T12022 |
T12019 |
pobj |
structures,with |
R7898 |
T12023 |
T12022 |
compound |
input,structures |
R7899 |
T12024 |
T12005 |
punct |
.,make |
R7900 |
T12026 |
T12027 |
nummod |
One,possibility |
R7901 |
T12027 |
T12028 |
nsubj |
possibility,be |
R7902 |
T12029 |
T12028 |
aux |
would,be |
R7903 |
T12030 |
T12031 |
npadvmod |
Cre,mediated |
R7904 |
T12031 |
T12033 |
amod |
mediated,depletion |
R7905 |
T12032 |
T12031 |
punct |
-,mediated |
R7906 |
T12033 |
T12028 |
attr |
depletion,be |
R7907 |
T12034 |
T12035 |
compound |
GluR,B |
R7908 |
T12035 |
T12033 |
compound |
B,depletion |
R7909 |
T12036 |
T12035 |
punct |
-,B |
R7910 |
T12037 |
T12033 |
cc |
and,depletion |
R7911 |
T12038 |
T12039 |
nmod |
GluR,B |
R7912 |
T12039 |
T12041 |
nmod |
B,expression |
R7913 |
T12040 |
T12039 |
punct |
-,B |
R7914 |
T12041 |
T12033 |
conj |
expression,depletion |
R7915 |
T12042 |
T12043 |
punct |
(,Q |
R7916 |
T12043 |
T12041 |
parataxis |
Q,expression |
R7917 |
T12044 |
T12043 |
punct |
),Q |
R7918 |
T12045 |
T12033 |
prep |
in,depletion |
R7919 |
T12046 |
T12047 |
amod |
piriform,cortex |
R7920 |
T12047 |
T12045 |
pobj |
cortex,in |
R7921 |
T12048 |
T12049 |
mark |
as,suggested |
R7922 |
T12049 |
T12028 |
advcl |
suggested,be |
R7923 |
T12050 |
T12049 |
advmod |
above,suggested |
R7924 |
T12051 |
T12028 |
punct |
.,be |
R7931 |
T12236 |
T12237 |
amod |
Quantitative,Behavior |
R7932 |
T12237 |
T12235 |
dobj |
Behavior,Correlating |
R7933 |
T12238 |
T12237 |
cc |
and,Behavior |
R7934 |
T12239 |
T12240 |
compound |
Mosaic,Expression |
R7935 |
T12240 |
T12237 |
conj |
Expression,Behavior |
R7936 |
T12241 |
T12240 |
compound |
Gene,Expression |
R7937 |
T12242 |
T12235 |
prep |
for,Correlating |
R7938 |
T12243 |
T12242 |
pcomp |
Dissecting,for |
R7939 |
T12244 |
T12243 |
dobj |
Phenotypes,Dissecting |
R7940 |
T12246 |
T12247 |
det |
A,step |
R7941 |
T12247 |
T12249 |
nsubj |
step,was |
R7942 |
T12248 |
T12247 |
amod |
critical,step |
R7943 |
T12250 |
T12247 |
prep |
in,step |
R7944 |
T12251 |
T12250 |
pcomp |
discerning,in |
R7945 |
T12252 |
T12253 |
det |
the,discrimination |
R7946 |
T12253 |
T12251 |
dobj |
discrimination,discerning |
R7947 |
T12254 |
T12251 |
cc |
and,discerning |
R7948 |
T12255 |
T12251 |
conj |
learning,discerning |
R7949 |
T12256 |
T12255 |
dobj |
phenotypes,learning |
R7950 |
T12257 |
T12255 |
prep |
from,learning |
R7951 |
T12258 |
T12259 |
det |
the,phenotype |
R7952 |
T12259 |
T12257 |
pobj |
phenotype,from |
R7953 |
T12260 |
T12259 |
compound |
memory,phenotype |
R7954 |
T12261 |
T12262 |
det |
the,observation |
R7955 |
T12262 |
T12249 |
attr |
observation,was |
R7956 |
T12263 |
T12262 |
prep |
of,observation |
R7957 |
T12264 |
T12265 |
amod |
increased,variability |
R7958 |
T12265 |
T12263 |
pobj |
variability,of |
R7959 |
T12266 |
T12265 |
prep |
in,variability |
R7960 |
T12267 |
T12268 |
det |
the,memory |
R7961 |
T12268 |
T12266 |
pobj |
memory,in |
R7962 |
T12269 |
T12268 |
prep |
of,memory |
R7963 |
T12270 |
T12271 |
det |
the,animals |
R7964 |
T12271 |
T12269 |
pobj |
animals,of |
R7965 |
T12272 |
T12273 |
compound |
GluR,B |
R7966 |
T12273 |
T12271 |
compound |
B,animals |
R7967 |
T12274 |
T12273 |
punct |
-,B |
R7968 |
T12275 |
T12271 |
compound |
knockout,animals |
R7969 |
T12276 |
T12262 |
cc |
and,observation |
R7970 |
T12277 |
T12262 |
punct |
", ",observation |
R7971 |
T12278 |
T12279 |
advmod |
subsequently,analyses |
R7972 |
T12279 |
T12262 |
conj |
analyses,observation |
R7973 |
T12280 |
T12279 |
punct |
", ",analyses |
R7974 |
T12281 |
T12279 |
det |
the,analyses |
R7975 |
T12282 |
T12279 |
amod |
individual,analyses |
R7976 |
T12283 |
T12279 |
prep |
of,analyses |
R7977 |
T12284 |
T12285 |
compound |
protein,levels |
R7978 |
T12285 |
T12283 |
pobj |
levels,of |
R7979 |
T12286 |
T12285 |
compound |
expression,levels |
R7980 |
T12287 |
T12249 |
punct |
.,was |
R7981 |
T12289 |
T12290 |
nsubj |
We,made |
R7982 |
T12291 |
T12290 |
dobj |
use,made |
R7983 |
T12292 |
T12290 |
prep |
of,made |
R7984 |
T12293 |
T12294 |
det |
the,variability |
R7985 |
T12294 |
T12292 |
pobj |
variability,of |
R7986 |
T12295 |
T12294 |
amod |
epigenetic,variability |
R7987 |
T12296 |
T12294 |
prep |
in,variability |
R7988 |
T12297 |
T12298 |
compound |
GluR,B |
R7989 |
T12298 |
T12300 |
compound |
B,excision |
R7990 |
T12299 |
T12298 |
punct |
-,B |
R7991 |
T12300 |
T12296 |
pobj |
excision,in |
R7992 |
T12301 |
T12302 |
dep |
that,correlated |
R7993 |
T12302 |
T12294 |
relcl |
correlated,variability |
R7994 |
T12303 |
T12302 |
aux |
could,correlated |
R7995 |
T12304 |
T12302 |
auxpass |
be,correlated |
R7996 |
T12305 |
T12302 |
prep |
to,correlated |
R7997 |
T12306 |
T12307 |
det |
the,variability |
R7998 |
T12307 |
T12305 |
pobj |
variability,to |
R7999 |
T12308 |
T12307 |
prep |
in,variability |
R8000 |
T12309 |
T12308 |
pobj |
memory,in |
R8001 |
T12310 |
T12302 |
cc |
but,correlated |
R8002 |
T12311 |
T12302 |
conj |
showed,correlated |
R8003 |
T12312 |
T12313 |
det |
no,correlation |
R8004 |
T12313 |
T12311 |
dobj |
correlation,showed |
R8005 |
T12314 |
T12313 |
prep |
to,correlation |
R8006 |
T12315 |
T12314 |
pobj |
variability,to |
R8007 |
T12316 |
T12315 |
prep |
in,variability |
R8008 |
T12317 |
T12316 |
pobj |
discrimination,in |
R8009 |
T12318 |
T12290 |
punct |
.,made |
R8010 |
T12320 |
T12321 |
det |
The,analysis |
R8011 |
T12321 |
T12322 |
nsubj |
analysis,attempts |
R8012 |
T12323 |
T12321 |
prep |
of,analysis |
R8013 |
T12324 |
T12325 |
amod |
quantitative,trait |
R8014 |
T12325 |
T12326 |
compound |
trait,loci |
R8015 |
T12326 |
T12323 |
pobj |
loci,of |
R8016 |
T12327 |
T12328 |
punct |
(,see |
R8017 |
T12328 |
T12326 |
parataxis |
see,loci |
R8018 |
T12329 |
T12328 |
prep |
for,see |
R8019 |
T12330 |
T12329 |
pobj |
review,for |
R8020 |
T12331 |
T12328 |
punct |
", ",see |
R8021 |
T12332 |
T12328 |
punct |
[,see |
R8022 |
T12333 |
T12328 |
dobj |
80,see |
R8023 |
T12334 |
T12328 |
punct |
],see |
R8024 |
T12335 |
T12328 |
punct |
),see |
R8025 |
T12336 |
T12326 |
punct |
", ",loci |
R8026 |
T12337 |
T12326 |
cc |
or,loci |
R8027 |
T12338 |
T12339 |
advmod |
classically,correlating |
R8028 |
T12339 |
T12340 |
amod |
correlating,phenotypes |
R8029 |
T12340 |
T12326 |
conj |
phenotypes,loci |
R8030 |
T12341 |
T12340 |
amod |
different,phenotypes |
R8031 |
T12342 |
T12340 |
amod |
behavioral,phenotypes |
R8032 |
T12343 |
T12321 |
prep |
within,analysis |
R8033 |
T12344 |
T12345 |
det |
a,population |
R8034 |
T12345 |
T12343 |
pobj |
population,within |
R8035 |
T12346 |
T12345 |
advmod |
truly,population |
R8036 |
T12347 |
T12348 |
amod |
wild,type |
R8037 |
T12348 |
T12345 |
compound |
type,population |
R8038 |
T12349 |
T12348 |
punct |
-,type |
R8039 |
T12350 |
T12351 |
punct |
[,81 |
R8040 |
T12351 |
T12321 |
parataxis |
81,analysis |
R8041 |
T12352 |
T12353 |
punct |
–,84 |
R8042 |
T12353 |
T12351 |
prep |
84,81 |
R8043 |
T12354 |
T12351 |
punct |
],81 |
R8044 |
T12355 |
T12322 |
punct |
", ",attempts |
R8045 |
T12356 |
T12322 |
advmod |
also,attempts |
R8046 |
T12357 |
T12358 |
aux |
to,find |
R8047 |
T12358 |
T12322 |
xcomp |
find,attempts |
R8048 |
T12359 |
T12360 |
amod |
common,origins |
R8049 |
T12360 |
T12358 |
dobj |
origins,find |
R8050 |
T12361 |
T12359 |
cc |
or,common |
R8051 |
T12362 |
T12359 |
conj |
distinct,common |
R8052 |
T12363 |
T12360 |
amod |
genetic,origins |
R8053 |
T12364 |
T12360 |
prep |
of,origins |
R8054 |
T12365 |
T12366 |
amod |
different,traits |
R8055 |
T12366 |
T12364 |
pobj |
traits,of |
R8056 |
T12367 |
T12366 |
amod |
behavioral,traits |
R8057 |
T12368 |
T12322 |
punct |
.,attempts |
R8058 |
T12370 |
T12371 |
det |
These,attempts |
R8059 |
T12371 |
T12372 |
nsubj |
attempts,contribute |
R8060 |
T12373 |
T12372 |
advmod |
undoubtedly,contribute |
R8061 |
T12374 |
T12372 |
advmod |
significantly,contribute |
R8062 |
T12375 |
T12372 |
prep |
to,contribute |
R8063 |
T12376 |
T12375 |
pcomp |
unraveling,to |
R8064 |
T12377 |
T12378 |
det |
the,basis |
R8065 |
T12378 |
T12376 |
dobj |
basis,unraveling |
R8066 |
T12379 |
T12378 |
amod |
molecular,basis |
R8067 |
T12380 |
T12378 |
prep |
of,basis |
R8068 |
T12381 |
T12380 |
pobj |
behavior,of |
R8069 |
T12382 |
T12372 |
punct |
.,contribute |
R8070 |
T12384 |
T12385 |
prep |
Due,suffer |
R8071 |
T12386 |
T12384 |
pcomp |
to,Due |
R8072 |
T12387 |
T12388 |
amod |
subtle,differences |
R8073 |
T12388 |
T12384 |
pobj |
differences,Due |
R8074 |
T12389 |
T12387 |
cc |
and,subtle |
R8075 |
T12390 |
T12387 |
conj |
multigenic,subtle |
R8076 |
T12391 |
T12388 |
prep |
between,differences |
R8077 |
T12392 |
T12393 |
amod |
different,strains |
R8078 |
T12393 |
T12391 |
pobj |
strains,between |
R8079 |
T12394 |
T12393 |
prep |
of,strains |
R8080 |
T12395 |
T12394 |
pobj |
rodents,of |
R8081 |
T12396 |
T12393 |
cc |
or,strains |
R8082 |
T12397 |
T12398 |
amod |
different,individuals |
R8083 |
T12398 |
T12393 |
conj |
individuals,strains |
R8084 |
T12399 |
T12388 |
prep |
in,differences |
R8085 |
T12400 |
T12401 |
det |
a,population |
R8086 |
T12401 |
T12399 |
pobj |
population,in |
R8087 |
T12402 |
T12403 |
amod |
wild,type |
R8088 |
T12403 |
T12401 |
compound |
type,population |
R8089 |
T12404 |
T12403 |
punct |
-,type |
R8090 |
T12405 |
T12385 |
punct |
", ",suffer |
R8091 |
T12406 |
T12385 |
advmod |
however,suffer |
R8092 |
T12407 |
T12385 |
punct |
", ",suffer |
R8093 |
T12408 |
T12385 |
nsubj |
they,suffer |
R8094 |
T12409 |
T12385 |
prep |
from,suffer |
R8095 |
T12410 |
T12411 |
det |
a,ratio |
R8096 |
T12411 |
T12409 |
pobj |
ratio,from |
R8097 |
T12412 |
T12413 |
advmod |
rather,low |
R8098 |
T12413 |
T12411 |
amod |
low,ratio |
R8099 |
T12414 |
T12411 |
punct |
“,ratio |
R8100 |
T12415 |
T12411 |
nmod |
signal,ratio |
R8101 |
T12416 |
T12415 |
punct |
-,signal |
R8102 |
T12417 |
T12415 |
prep |
to,signal |
R8103 |
T12418 |
T12417 |
punct |
-,to |
R8104 |
T12419 |
T12417 |
pobj |
noise,to |
R8105 |
T12420 |
T12411 |
punct |
”,ratio |
R8106 |
T12421 |
T12385 |
punct |
.,suffer |
R8107 |
T12423 |
T12424 |
nsubj |
Differences,are |
R8108 |
T12425 |
T12423 |
prep |
in,Differences |
R8109 |
T12426 |
T12427 |
amod |
individual,genes |
R8110 |
T12427 |
T12425 |
pobj |
genes,in |
R8111 |
T12428 |
T12429 |
advmod |
rather,small |
R8112 |
T12429 |
T12424 |
acomp |
small,are |
R8113 |
T12430 |
T12424 |
prep |
compared,are |
R8114 |
T12431 |
T12430 |
prep |
with,compared |
R8115 |
T12432 |
T12433 |
det |
the,number |
R8116 |
T12433 |
T12431 |
pobj |
number,with |
R8117 |
T12434 |
T12433 |
amod |
vast,number |
R8118 |
T12435 |
T12433 |
prep |
of,number |
R8119 |
T12436 |
T12435 |
pobj |
genes,of |
R8120 |
T12437 |
T12436 |
acl |
involved,genes |
R8121 |
T12438 |
T12424 |
punct |
.,are |
R8122 |
T12440 |
T12441 |
prep |
As,remains |
R8123 |
T12442 |
T12443 |
det |
a,result |
R8124 |
T12443 |
T12440 |
pobj |
result,As |
R8125 |
T12444 |
T12441 |
punct |
", ",remains |
R8126 |
T12445 |
T12446 |
advmod |
purely,correlating |
R8127 |
T12446 |
T12447 |
amod |
correlating,traits |
R8128 |
T12447 |
T12441 |
nsubj |
traits,remains |
R8129 |
T12448 |
T12447 |
amod |
behavioral,traits |
R8130 |
T12449 |
T12447 |
prep |
within,traits |
R8131 |
T12450 |
T12451 |
det |
a,population |
R8132 |
T12451 |
T12449 |
pobj |
population,within |
R8133 |
T12452 |
T12453 |
amod |
wild,type |
R8134 |
T12453 |
T12451 |
compound |
type,population |
R8135 |
T12454 |
T12453 |
punct |
-,type |
R8136 |
T12455 |
T12441 |
advmod |
usually,remains |
R8137 |
T12456 |
T12457 |
advmod |
rather,descriptive |
R8138 |
T12457 |
T12441 |
oprd |
descriptive,remains |
R8139 |
T12458 |
T12441 |
punct |
", ",remains |
R8140 |
T12459 |
T12460 |
mark |
whereas,is |
R8141 |
T12460 |
T12441 |
advcl |
is,remains |
R8142 |
T12461 |
T12462 |
amod |
quantitative,trait |
R8143 |
T12462 |
T12463 |
compound |
trait,loci |
R8144 |
T12463 |
T12464 |
compound |
loci,analysis |
R8145 |
T12464 |
T12460 |
nsubj |
analysis,is |
R8146 |
T12465 |
T12460 |
acomp |
capable,is |
R8147 |
T12466 |
T12465 |
prep |
of,capable |
R8148 |
T12467 |
T12466 |
pcomp |
revealing,of |
R8149 |
T12468 |
T12469 |
amod |
multigenic,basis |
R8150 |
T12469 |
T12467 |
dobj |
basis,revealing |
R8151 |
T12470 |
T12469 |
prep |
of,basis |
R8152 |
T12471 |
T12472 |
amod |
behavioral,traits |
R8153 |
T12472 |
T12470 |
pobj |
traits,of |
R8154 |
T12473 |
T12460 |
cc |
but,is |
R8155 |
T12474 |
T12475 |
advmod |
usually,lacks |
R8156 |
T12475 |
T12460 |
conj |
lacks,is |
R8157 |
T12476 |
T12477 |
det |
the,power |
R8158 |
T12477 |
T12475 |
dobj |
power,lacks |
R8159 |
T12478 |
T12479 |
aux |
to,identify |
R8160 |
T12479 |
T12477 |
acl |
identify,power |
R8161 |
T12480 |
T12481 |
det |
the,genes |
R8162 |
T12481 |
T12479 |
dobj |
genes,identify |
R8163 |
T12482 |
T12481 |
amod |
individual,genes |
R8164 |
T12483 |
T12481 |
appos |
themselves,genes |
R8165 |
T12484 |
T12441 |
punct |
.,remains |
R8166 |
T12486 |
T12487 |
advmod |
Herein,described |
R8167 |
T12487 |
T12490 |
ccomp |
described,provide |
R8168 |
T12488 |
T12487 |
punct |
", ",described |
R8169 |
T12489 |
T12487 |
nsubj |
we,described |
R8170 |
T12491 |
T12492 |
det |
a,way |
R8171 |
T12492 |
T12487 |
dobj |
way,described |
R8172 |
T12493 |
T12494 |
aux |
to,enhance |
R8173 |
T12494 |
T12492 |
advcl |
enhance,way |
R8174 |
T12495 |
T12496 |
det |
the,ratio |
R8175 |
T12496 |
T12494 |
dobj |
ratio,enhance |
R8176 |
T12497 |
T12496 |
nmod |
signal,ratio |
R8177 |
T12498 |
T12497 |
punct |
-,signal |
R8178 |
T12499 |
T12497 |
prep |
to,signal |
R8179 |
T12500 |
T12499 |
punct |
-,to |
R8180 |
T12501 |
T12499 |
pobj |
noise,to |
R8181 |
T12502 |
T12494 |
prep |
by,enhance |
R8182 |
T12503 |
T12502 |
pcomp |
making,by |
R8183 |
T12504 |
T12503 |
dobj |
use,making |
R8184 |
T12505 |
T12503 |
prep |
of,making |
R8185 |
T12506 |
T12507 |
det |
the,expression |
R8186 |
T12507 |
T12505 |
pobj |
expression,of |
R8187 |
T12508 |
T12507 |
compound |
mosaic,expression |
R8188 |
T12509 |
T12510 |
advmod |
often,associated |
R8189 |
T12510 |
T12507 |
acl |
associated,expression |
R8190 |
T12511 |
T12510 |
prep |
with,associated |
R8191 |
T12512 |
T12513 |
amod |
transgenic,approaches |
R8192 |
T12513 |
T12511 |
pobj |
approaches,with |
R8193 |
T12514 |
T12490 |
punct |
: ,provide |
R8194 |
T12515 |
T12490 |
csubj |
combining,provide |
R8195 |
T12516 |
T12517 |
det |
the,advantages |
R8196 |
T12517 |
T12515 |
dobj |
advantages,combining |
R8197 |
T12518 |
T12517 |
prep |
of,advantages |
R8198 |
T12519 |
T12520 |
punct |
“,manipulation |
R8199 |
T12520 |
T12518 |
pobj |
manipulation,of |
R8200 |
T12521 |
T12520 |
amod |
classical,manipulation |
R8201 |
T12522 |
T12520 |
punct |
”,manipulation |
R8202 |
T12523 |
T12520 |
amod |
genetic,manipulation |
R8203 |
T12524 |
T12520 |
punct |
—,manipulation |
R8204 |
T12525 |
T12526 |
advmod |
namely,is |
R8205 |
T12526 |
T12517 |
acl |
is,advantages |
R8206 |
T12527 |
T12526 |
punct |
", ",is |
R8207 |
T12528 |
T12526 |
mark |
that,is |
R8208 |
T12529 |
T12530 |
det |
the,target |
R8209 |
T12530 |
T12526 |
nsubj |
target,is |
R8210 |
T12531 |
T12530 |
prep |
of,target |
R8211 |
T12532 |
T12533 |
det |
the,manipulation |
R8212 |
T12533 |
T12531 |
pobj |
manipulation,of |
R8213 |
T12534 |
T12535 |
advmod |
well,defined |
R8214 |
T12535 |
T12526 |
acomp |
defined,is |
R8215 |
T12536 |
T12515 |
punct |
—,combining |
R8216 |
T12537 |
T12515 |
prep |
with,combining |
R8217 |
T12538 |
T12539 |
det |
the,possibility |
R8218 |
T12539 |
T12537 |
pobj |
possibility,with |
R8219 |
T12540 |
T12541 |
aux |
to,analyze |
R8220 |
T12541 |
T12539 |
acl |
analyze,possibility |
R8221 |
T12542 |
T12541 |
dobj |
variability,analyze |
R8222 |
T12543 |
T12490 |
punct |
", ",provide |
R8223 |
T12544 |
T12490 |
aux |
might,provide |
R8224 |
T12545 |
T12490 |
advmod |
also,provide |
R8225 |
T12546 |
T12490 |
prep |
in,provide |
R8226 |
T12547 |
T12546 |
pobj |
future,in |
R8227 |
T12548 |
T12549 |
amod |
novel,ways |
R8228 |
T12549 |
T12490 |
dobj |
ways,provide |
R8229 |
T12550 |
T12551 |
aux |
to,define |
R8230 |
T12551 |
T12549 |
advcl |
define,ways |
R8231 |
T12552 |
T12553 |
amod |
molecular,correlates |
R8232 |
T12553 |
T12551 |
dobj |
correlates,define |
R8233 |
T12554 |
T12552 |
cc |
and,molecular |
R8234 |
T12555 |
T12552 |
conj |
cellular,molecular |
R8235 |
T12556 |
T12553 |
prep |
of,correlates |
R8236 |
T12557 |
T12558 |
amod |
complex,traits |
R8237 |
T12558 |
T12556 |
pobj |
traits,of |
R8238 |
T12559 |
T12558 |
amod |
behavioral,traits |
R8239 |
T12560 |
T12490 |
punct |
.,provide |
R8240 |
T12562 |
T12563 |
prep |
In,combined |
R8241 |
T12564 |
T12565 |
det |
this,study |
R8242 |
T12565 |
T12562 |
pobj |
study,In |
R8243 |
T12566 |
T12563 |
punct |
", ",combined |
R8244 |
T12567 |
T12563 |
nsubj |
we,combined |
R8245 |
T12568 |
T12569 |
advmod |
genetically,induced |
R8246 |
T12569 |
T12570 |
amod |
induced,manipulation |
R8247 |
T12570 |
T12563 |
dobj |
manipulation,combined |
R8248 |
T12571 |
T12570 |
prep |
of,manipulation |
R8249 |
T12572 |
T12573 |
det |
the,composition |
R8250 |
T12573 |
T12571 |
pobj |
composition,of |
R8251 |
T12574 |
T12573 |
compound |
AMPAR,composition |
R8252 |
T12575 |
T12563 |
prep |
with,combined |
R8253 |
T12576 |
T12577 |
amod |
quantitative,analyses |
R8254 |
T12577 |
T12575 |
pobj |
analyses,with |
R8255 |
T12578 |
T12577 |
amod |
behavioral,analyses |
R8256 |
T12579 |
T12578 |
cc |
and,behavioral |
R8257 |
T12580 |
T12578 |
conj |
molecular,behavioral |
R8258 |
T12581 |
T12563 |
punct |
.,combined |
R8259 |
T12583 |
T12584 |
nsubj |
We,provide |
R8260 |
T12585 |
T12584 |
aux |
could,provide |
R8261 |
T12586 |
T12584 |
advmod |
thus,provide |
R8262 |
T12587 |
T12584 |
dobj |
evidence,provide |
R8263 |
T12588 |
T12587 |
prep |
for,evidence |
R8264 |
T12589 |
T12590 |
amod |
opposing,roles |
R8265 |
T12590 |
T12588 |
pobj |
roles,for |
R8266 |
T12591 |
T12590 |
prep |
of,roles |
R8267 |
T12592 |
T12593 |
amod |
specific,manipulation |
R8268 |
T12593 |
T12591 |
pobj |
manipulation,of |
R8269 |
T12594 |
T12595 |
compound |
GluR,B |
R8270 |
T12595 |
T12593 |
compound |
B,manipulation |
R8271 |
T12596 |
T12595 |
punct |
-,B |
R8272 |
T12597 |
T12593 |
cc |
and,manipulation |
R8273 |
T12598 |
T12599 |
amod |
increased,influx |
R8274 |
T12599 |
T12593 |
conj |
influx,manipulation |
R8275 |
T12600 |
T12599 |
nmod |
Ca2,influx |
R8276 |
T12601 |
T12600 |
punct |
+,Ca2 |
R8277 |
T12602 |
T12599 |
prep |
via,influx |
R8278 |
T12603 |
T12602 |
pobj |
AMPARs,via |
R8279 |
T12604 |
T12590 |
prep |
in,roles |
R8280 |
T12605 |
T12606 |
amod |
olfactory,learning |
R8281 |
T12606 |
T12604 |
pobj |
learning,in |
R8282 |
T12607 |
T12606 |
compound |
discrimination,learning |
R8283 |
T12608 |
T12606 |
punct |
/,learning |
R8284 |
T12609 |
T12606 |
punct |
", ",learning |
R8285 |
T12610 |
T12606 |
cc |
and,learning |
R8286 |
T12611 |
T12606 |
conj |
memory,learning |
R8287 |
T12612 |
T12606 |
punct |
", ",learning |
R8288 |
T12613 |
T12614 |
advmod |
potentially,in |
R8289 |
T12614 |
T12606 |
prep |
in,learning |
R8290 |
T12615 |
T12616 |
det |
the,bulb |
R8291 |
T12616 |
T12614 |
pobj |
bulb,in |
R8292 |
T12617 |
T12616 |
amod |
olfactory,bulb |
R8293 |
T12618 |
T12616 |
cc |
and,bulb |
R8294 |
T12619 |
T12620 |
amod |
piriform,cortex |
R8295 |
T12620 |
T12616 |
conj |
cortex,bulb |
R8296 |
T12621 |
T12616 |
punct |
", ",bulb |
R8297 |
T12622 |
T12616 |
advmod |
respectively,bulb |
R8298 |
T12623 |
T12584 |
punct |
.,provide |
R8299 |
T12625 |
T12626 |
aux |
To,achieve |
R8300 |
T12626 |
T12627 |
advcl |
achieve,made |
R8301 |
T12627 |
T12631 |
ccomp |
made,confirmed |
R8302 |
T12628 |
T12626 |
dobj |
this,achieve |
R8303 |
T12629 |
T12627 |
punct |
", ",made |
R8304 |
T12630 |
T12627 |
nsubj |
we,made |
R8305 |
T12632 |
T12627 |
dobj |
use,made |
R8306 |
T12633 |
T12627 |
prep |
of,made |
R8307 |
T12634 |
T12635 |
det |
the,variability |
R8308 |
T12635 |
T12633 |
pobj |
variability,of |
R8309 |
T12636 |
T12635 |
amod |
epigenetic,variability |
R8310 |
T12637 |
T12635 |
prep |
in,variability |
R8311 |
T12638 |
T12639 |
det |
the,extent |
R8312 |
T12639 |
T12637 |
pobj |
extent,in |
R8313 |
T12640 |
T12639 |
prep |
of,extent |
R8314 |
T12641 |
T12642 |
compound |
GluR,B |
R8315 |
T12642 |
T12644 |
compound |
B,ablation |
R8316 |
T12643 |
T12642 |
punct |
-,B |
R8317 |
T12644 |
T12640 |
pobj |
ablation,of |
R8318 |
T12645 |
T12639 |
punct |
", ",extent |
R8319 |
T12646 |
T12647 |
dep |
which,correlated |
R8320 |
T12647 |
T12639 |
relcl |
correlated,extent |
R8321 |
T12648 |
T12647 |
prep |
with,correlated |
R8322 |
T12649 |
T12650 |
det |
the,variability |
R8323 |
T12650 |
T12648 |
pobj |
variability,with |
R8324 |
T12651 |
T12650 |
prep |
in,variability |
R8325 |
T12652 |
T12653 |
compound |
odor,memory |
R8326 |
T12653 |
T12651 |
pobj |
memory,in |
R8327 |
T12654 |
T12651 |
punct |
", ",in |
R8328 |
T12655 |
T12651 |
cc |
but,in |
R8329 |
T12656 |
T12655 |
neg |
not,but |
R8330 |
T12657 |
T12651 |
conj |
in,in |
R8331 |
T12658 |
T12657 |
pobj |
discrimination,in |
R8332 |
T12659 |
T12658 |
cc |
and,discrimination |
R8333 |
T12660 |
T12658 |
conj |
learning,discrimination |
R8334 |
T12661 |
T12631 |
punct |
;,confirmed |
R8335 |
T12662 |
T12663 |
det |
this,finding |
R8336 |
T12663 |
T12631 |
nsubjpass |
finding,confirmed |
R8337 |
T12664 |
T12631 |
auxpass |
was,confirmed |
R8338 |
T12665 |
T12631 |
advmod |
subsequently,confirmed |
R8339 |
T12666 |
T12631 |
prep |
in,confirmed |
R8340 |
T12667 |
T12668 |
compound |
GluR,B |
R8341 |
T12668 |
T12670 |
compound |
B,mice |
R8342 |
T12669 |
T12668 |
punct |
-,B |
R8343 |
T12670 |
T12666 |
pobj |
mice,in |
R8344 |
T12671 |
T12670 |
compound |
rescue,mice |
R8345 |
T12672 |
T12670 |
prep |
with,mice |
R8346 |
T12673 |
T12674 |
amod |
piriform,cortex |
R8347 |
T12674 |
T12675 |
npadvmod |
cortex,specific |
R8348 |
T12675 |
T12677 |
amod |
specific,expression |
R8349 |
T12676 |
T12675 |
punct |
-,specific |
R8350 |
T12677 |
T12672 |
pobj |
expression,with |
R8351 |
T12678 |
T12677 |
amod |
transgenic,expression |
R8352 |
T12679 |
T12677 |
prep |
of,expression |
R8353 |
T12680 |
T12681 |
compound |
GluR,B |
R8354 |
T12681 |
T12679 |
pobj |
B,of |
R8355 |
T12682 |
T12681 |
punct |
-,B |
R8356 |
T12683 |
T12631 |
punct |
.,confirmed |
R8357 |
T12685 |
T12686 |
csubj |
Extending,pinpoint |
R8358 |
T12687 |
T12688 |
det |
these,principles |
R8359 |
T12688 |
T12685 |
dobj |
principles,Extending |
R8360 |
T12689 |
T12688 |
prep |
of,principles |
R8361 |
T12690 |
T12689 |
pcomp |
combining,of |
R8362 |
T12691 |
T12692 |
amod |
quantitative,analyses |
R8363 |
T12692 |
T12690 |
dobj |
analyses,combining |
R8364 |
T12693 |
T12692 |
amod |
behavioral,analyses |
R8365 |
T12694 |
T12690 |
prep |
with,combining |
R8366 |
T12695 |
T12696 |
amod |
minimal,interference |
R8367 |
T12696 |
T12694 |
pobj |
interference,with |
R8368 |
T12697 |
T12695 |
cc |
and,minimal |
R8369 |
T12698 |
T12695 |
conj |
dosed,minimal |
R8370 |
T12699 |
T12696 |
amod |
genetic,interference |
R8371 |
T12700 |
T12696 |
punct |
", ",interference |
R8372 |
T12701 |
T12696 |
advmod |
together,interference |
R8373 |
T12702 |
T12701 |
prep |
with,together |
R8374 |
T12703 |
T12704 |
amod |
further,analyses |
R8375 |
T12704 |
T12702 |
pobj |
analyses,with |
R8376 |
T12705 |
T12704 |
amod |
physiological,analyses |
R8377 |
T12706 |
T12686 |
punct |
", ",pinpoint |
R8378 |
T12707 |
T12686 |
aux |
will,pinpoint |
R8379 |
T12708 |
T12686 |
advmod |
ultimately,pinpoint |
R8380 |
T12709 |
T12710 |
det |
the,circuitries |
R8381 |
T12710 |
T12686 |
dobj |
circuitries,pinpoint |
R8382 |
T12711 |
T12710 |
amod |
neural,circuitries |
R8383 |
T12712 |
T12710 |
acl |
underlying,circuitries |
R8384 |
T12713 |
T12714 |
amod |
related,traits |
R8385 |
T12714 |
T12712 |
dobj |
traits,underlying |
R8386 |
T12715 |
T12713 |
punct |
", ",related |
R8387 |
T12716 |
T12713 |
cc |
but,related |
R8388 |
T12717 |
T12713 |
conj |
distinct,related |
R8389 |
T12718 |
T12714 |
punct |
", ",traits |
R8390 |
T12719 |
T12714 |
amod |
behavioral,traits |
R8391 |
T12720 |
T12712 |
prep |
in,underlying |
R8392 |
T12721 |
T12722 |
amod |
olfactory,systems |
R8393 |
T12722 |
T12720 |
pobj |
systems,in |
R8394 |
T12723 |
T12721 |
cc |
and,olfactory |
R8395 |
T12724 |
T12721 |
conj |
other,olfactory |
R8396 |
T12725 |
T12686 |
punct |
.,pinpoint |
R8399 |
T12911 |
T12912 |
compound |
Mouse,lines |
R8400 |
T12914 |
T12915 |
det |
The,line |
R8401 |
T12915 |
T12917 |
nsubjpass |
line,employed |
R8402 |
T12916 |
T12915 |
compound |
R26R,line |
R8403 |
T12918 |
T12919 |
punct |
[,85 |
R8404 |
T12919 |
T12915 |
parataxis |
85,line |
R8405 |
T12920 |
T12919 |
punct |
],85 |
R8406 |
T12921 |
T12917 |
auxpass |
was,employed |
R8407 |
T12922 |
T12917 |
prep |
as,employed |
R8408 |
T12923 |
T12924 |
compound |
Cre,indicator |
R8409 |
T12924 |
T12922 |
pobj |
indicator,as |
R8410 |
T12925 |
T12917 |
punct |
.,employed |
R8411 |
T12927 |
T12928 |
nmod |
GluR,B ΔECS |
R8412 |
T12928 |
T12930 |
nmod |
B ΔECS,mice |
R8413 |
T12929 |
T12928 |
punct |
-,B ΔECS |
R8414 |
T12930 |
T12933 |
nsubj |
mice,were |
R8415 |
T12931 |
T12928 |
punct |
:,B ΔECS |
R8416 |
T12932 |
T12928 |
appos |
FB,B ΔECS |
R8417 |
T12934 |
T12933 |
prep |
of,were |
R8418 |
T12935 |
T12936 |
amod |
mixed,background |
R8419 |
T12936 |
T12934 |
pobj |
background,of |
R8420 |
T12937 |
T12936 |
nmod |
C57,background |
R8421 |
T12938 |
T12936 |
nmod |
Bl,background |
R8422 |
T12939 |
T12938 |
punct |
/,Bl |
R8423 |
T12940 |
T12938 |
nummod |
6,Bl |
R8424 |
T12941 |
T12938 |
cc |
and,Bl |
R8425 |
T12942 |
T12938 |
conj |
NMRI,Bl |
R8426 |
T12943 |
T12936 |
amod |
genetic,background |
R8427 |
T12944 |
T12934 |
cc |
and,of |
R8428 |
T12945 |
T12934 |
conj |
generated,of |
R8429 |
T12946 |
T12945 |
prep |
from,generated |
R8430 |
T12947 |
T12948 |
nmod |
TgCre4,Camkcre4 |
R8431 |
T12948 |
T12946 |
pobj |
Camkcre4,from |
R8432 |
T12949 |
T12948 |
punct |
(,Camkcre4 |
R8433 |
T12950 |
T12948 |
punct |
“,Camkcre4 |
R8434 |
T12951 |
T12945 |
punct |
”,generated |
R8435 |
T12952 |
T12945 |
prep |
in,generated |
R8436 |
T12953 |
T12952 |
punct |
[,in |
R8437 |
T12954 |
T12952 |
pobj |
59,in |
R8438 |
T12955 |
T12954 |
punct |
],59 |
R8439 |
T12956 |
T12954 |
punct |
),59 |
R8440 |
T12957 |
T12954 |
cc |
and,59 |
R8441 |
T12958 |
T12959 |
nmod |
GluR,B |
R8442 |
T12959 |
T12961 |
nmod |
B,mice |
R8443 |
T12960 |
T12959 |
punct |
-,B |
R8444 |
T12961 |
T12954 |
conj |
mice,59 |
R8445 |
T12962 |
T12959 |
punct |
+,B |
R8446 |
T12963 |
T12959 |
punct |
/,B |
R8447 |
T12964 |
T12959 |
appos |
neo,B |
R8448 |
T12965 |
T12966 |
punct |
[,60 |
R8449 |
T12966 |
T12961 |
parataxis |
60,mice |
R8450 |
T12967 |
T12966 |
punct |
],60 |
R8451 |
T12968 |
T12933 |
punct |
.,were |
R8452 |
T12970 |
T12971 |
nmod |
GluR,B |
R8453 |
T12971 |
T12973 |
nmod |
B,mice |
R8454 |
T12972 |
T12971 |
punct |
-,B |
R8455 |
T12973 |
T12977 |
nsubj |
mice,carry |
R8456 |
T12974 |
T12971 |
punct |
+,B |
R8457 |
T12975 |
T12971 |
punct |
/,B |
R8458 |
T12976 |
T12971 |
appos |
neo,B |
R8459 |
T12978 |
T12979 |
det |
a,allele |
R8460 |
T12979 |
T12977 |
dobj |
allele,carry |
R8461 |
T12980 |
T12981 |
amod |
wild,type |
R8462 |
T12981 |
T12979 |
compound |
type,allele |
R8463 |
T12982 |
T12981 |
punct |
-,type |
R8464 |
T12983 |
T12984 |
compound |
GluR,B |
R8465 |
T12984 |
T12979 |
compound |
B,allele |
R8466 |
T12985 |
T12984 |
punct |
-,B |
R8467 |
T12986 |
T12979 |
cc |
and,allele |
R8468 |
T12987 |
T12988 |
det |
a,allele |
R8469 |
T12988 |
T12979 |
conj |
allele,allele |
R8470 |
T12989 |
T12990 |
npadvmod |
gene,targeted |
R8471 |
T12990 |
T12988 |
amod |
targeted,allele |
R8472 |
T12991 |
T12990 |
punct |
-,targeted |
R8473 |
T12992 |
T12993 |
compound |
GluR,B |
R8474 |
T12993 |
T12988 |
compound |
B,allele |
R8475 |
T12994 |
T12993 |
punct |
-,B |
R8476 |
T12995 |
T12996 |
prep |
in,replaced |
R8477 |
T12996 |
T12979 |
relcl |
replaced,allele |
R8478 |
T12997 |
T12995 |
pobj |
which,in |
R8479 |
T12998 |
T12999 |
det |
the,sequence |
R8480 |
T12999 |
T12996 |
nsubjpass |
sequence,replaced |
R8481 |
T13000 |
T12999 |
nmod |
intron,sequence |
R8482 |
T13001 |
T13000 |
nummod |
11,intron |
R8483 |
T13002 |
T12999 |
amod |
critical,sequence |
R8484 |
T13003 |
T13002 |
prep |
for,critical |
R8485 |
T13004 |
T13005 |
compound |
Q,R |
R8486 |
T13005 |
T13007 |
compound |
R,site |
R8487 |
T13006 |
T13005 |
punct |
/,R |
R8488 |
T13007 |
T13008 |
compound |
site,editing |
R8489 |
T13008 |
T13003 |
pobj |
editing,for |
R8490 |
T13009 |
T12996 |
auxpass |
is,replaced |
R8491 |
T13010 |
T12996 |
agent |
by,replaced |
R8492 |
T13011 |
T13012 |
det |
a,gene |
R8493 |
T13012 |
T13010 |
pobj |
gene,by |
R8494 |
T13013 |
T13014 |
compound |
TK,neo |
R8495 |
T13014 |
T13012 |
compound |
neo,gene |
R8496 |
T13015 |
T13014 |
punct |
-,neo |
R8497 |
T13016 |
T13012 |
acl |
flanked,gene |
R8498 |
T13017 |
T13016 |
agent |
by,flanked |
R8499 |
T13018 |
T13019 |
compound |
loxP,sites |
R8500 |
T13019 |
T13017 |
pobj |
sites,by |
R8501 |
T13020 |
T13021 |
punct |
(,floxed |
R8502 |
T13021 |
T13016 |
parataxis |
floxed,flanked |
R8503 |
T13022 |
T13021 |
punct |
“,floxed |
R8504 |
T13023 |
T13021 |
punct |
”,floxed |
R8505 |
T13024 |
T13021 |
punct |
),floxed |
R8506 |
T13025 |
T12977 |
punct |
.,carry |
R8507 |
T13027 |
T13028 |
compound |
GluR,B2lox |
R8508 |
T13028 |
T13030 |
compound |
B2lox,mice |
R8509 |
T13029 |
T13028 |
punct |
-,B2lox |
R8510 |
T13030 |
T13031 |
nsubj |
mice,carry |
R8511 |
T13032 |
T13033 |
punct |
[,86 |
R8512 |
T13033 |
T13030 |
parataxis |
86,mice |
R8513 |
T13034 |
T13033 |
punct |
],86 |
R8514 |
T13035 |
T13036 |
npadvmod |
gene,targeted |
R8515 |
T13036 |
T13038 |
amod |
targeted,alleles |
R8516 |
T13037 |
T13036 |
punct |
-,targeted |
R8517 |
T13038 |
T13031 |
dobj |
alleles,carry |
R8518 |
T13039 |
T13040 |
compound |
GluR,B |
R8519 |
T13040 |
T13038 |
compound |
B,alleles |
R8520 |
T13041 |
T13040 |
punct |
-,B |
R8521 |
T13042 |
T13043 |
prep |
in,floxed |
R8522 |
T13043 |
T13038 |
relcl |
floxed,alleles |
R8523 |
T13044 |
T13042 |
pobj |
which,in |
R8524 |
T13045 |
T13043 |
nsubjpass |
exon,floxed |
R8525 |
T13046 |
T13045 |
nummod |
11,exon |
R8526 |
T13047 |
T13043 |
auxpass |
is,floxed |
R8527 |
T13048 |
T13031 |
punct |
.,carry |
R8528 |
T13050 |
T13051 |
compound |
GluR,B ΔFB |
R8529 |
T13051 |
T13053 |
compound |
B ΔFB,mice |
R8530 |
T13052 |
T13051 |
punct |
-,B ΔFB |
R8531 |
T13053 |
T13054 |
nsubj |
mice,were |
R8532 |
T13055 |
T13054 |
prep |
of,were |
R8533 |
T13056 |
T13057 |
nmod |
C57Bl,background |
R8534 |
T13057 |
T13055 |
pobj |
background,of |
R8535 |
T13058 |
T13056 |
punct |
/,C57Bl |
R8536 |
T13059 |
T13056 |
nummod |
6,C57Bl |
R8537 |
T13060 |
T13057 |
amod |
genetic,background |
R8538 |
T13061 |
T13055 |
cc |
and,of |
R8539 |
T13062 |
T13055 |
conj |
generated,of |
R8540 |
T13063 |
T13062 |
prep |
from,generated |
R8541 |
T13064 |
T13065 |
nmod |
TgCre4,mice |
R8542 |
T13065 |
T13063 |
pobj |
mice,from |
R8543 |
T13066 |
T13064 |
cc |
and,TgCre4 |
R8544 |
T13067 |
T13068 |
compound |
GluR,B2lox |
R8545 |
T13068 |
T13064 |
conj |
B2lox,TgCre4 |
R8546 |
T13069 |
T13068 |
punct |
-,B2lox |
R8547 |
T13070 |
T13054 |
punct |
.,were |
R8548 |
T13072 |
T13073 |
compound |
TgCN12,itTA |
R8549 |
T13073 |
T13075 |
compound |
itTA,mice |
R8550 |
T13074 |
T13073 |
punct |
-,itTA |
R8551 |
T13075 |
T13076 |
nsubjpass |
mice,generated |
R8552 |
T13077 |
T13076 |
auxpass |
were,generated |
R8553 |
T13078 |
T13079 |
mark |
as,described |
R8554 |
T13079 |
T13076 |
advcl |
described,generated |
R8555 |
T13080 |
T13076 |
prep |
for,generated |
R8556 |
T13081 |
T13082 |
compound |
TgCN10,itTA |
R8557 |
T13082 |
T13084 |
compound |
itTA,mice |
R8558 |
T13083 |
T13082 |
punct |
-,itTA |
R8559 |
T13084 |
T13080 |
pobj |
mice,for |
R8560 |
T13085 |
T13086 |
punct |
(,see |
R8561 |
T13086 |
T13076 |
parataxis |
see,generated |
R8562 |
T13087 |
T13086 |
dobj |
Materials,see |
R8563 |
T13088 |
T13087 |
cc |
and,Materials |
R8564 |
T13089 |
T13087 |
conj |
Methods,Materials |
R8565 |
T13090 |
T13086 |
prep |
in,see |
R8566 |
T13091 |
T13090 |
punct |
[,in |
R8567 |
T13092 |
T13090 |
pobj |
58,in |
R8568 |
T13093 |
T13086 |
punct |
],see |
R8569 |
T13094 |
T13086 |
punct |
),see |
R8570 |
T13095 |
T13076 |
punct |
", ",generated |
R8571 |
T13096 |
T13076 |
cc |
and,generated |
R8572 |
T13097 |
T13076 |
conj |
represent,generated |
R8573 |
T13098 |
T13099 |
det |
another,line |
R8574 |
T13099 |
T13097 |
dobj |
line,represent |
R8575 |
T13100 |
T13099 |
compound |
founder,line |
R8576 |
T13101 |
T13099 |
acl |
obtained,line |
R8577 |
T13102 |
T13101 |
prep |
from,obtained |
R8578 |
T13103 |
T13104 |
det |
the,injection |
R8579 |
T13104 |
T13102 |
pobj |
injection,from |
R8580 |
T13105 |
T13104 |
amod |
same,injection |
R8581 |
T13106 |
T13104 |
compound |
pronucleus,injection |
R8582 |
T13107 |
T13099 |
punct |
", ",line |
R8583 |
T13108 |
T13099 |
prep |
with,line |
R8584 |
T13109 |
T13110 |
advmod |
more,widespread |
R8585 |
T13110 |
T13111 |
amod |
widespread,expression |
R8586 |
T13111 |
T13108 |
pobj |
expression,with |
R8587 |
T13112 |
T13111 |
compound |
forebrain,expression |
R8588 |
T13113 |
T13076 |
punct |
.,generated |
R8589 |
T13115 |
T13116 |
prep |
For,injected |
R8590 |
T13117 |
T13118 |
amod |
exogeneous,expression |
R8591 |
T13118 |
T13115 |
pobj |
expression,For |
R8592 |
T13119 |
T13118 |
prep |
of,expression |
R8593 |
T13120 |
T13121 |
compound |
GFPGluR,B |
R8594 |
T13121 |
T13119 |
pobj |
B,of |
R8595 |
T13122 |
T13121 |
punct |
-,B |
R8596 |
T13123 |
T13116 |
punct |
", ",injected |
R8597 |
T13124 |
T13125 |
det |
the,line |
R8598 |
T13125 |
T13127 |
nsubjpass |
line,generated |
R8599 |
T13126 |
T13125 |
compound |
mouse,line |
R8600 |
T13127 |
T13116 |
ccomp |
generated,injected |
R8601 |
T13128 |
T13125 |
appos |
TgOCN1,line |
R8602 |
T13129 |
T13127 |
auxpass |
was,generated |
R8603 |
T13130 |
T13116 |
punct |
: ,injected |
R8604 |
T13131 |
T13132 |
det |
an,fragment |
R8605 |
T13132 |
T13116 |
nsubjpass |
fragment,injected |
R8606 |
T13133 |
T13132 |
compound |
AseI,fragment |
R8607 |
T13134 |
T13132 |
prep |
of,fragment |
R8608 |
T13135 |
T13136 |
compound |
plasmid,pnlacZ |
R8609 |
T13136 |
T13134 |
pobj |
pnlacZ,of |
R8610 |
T13137 |
T13136 |
punct |
/,pnlacZ |
R8611 |
T13138 |
T13139 |
compound |
GFPGluR,B |
R8612 |
T13139 |
T13136 |
appos |
B,pnlacZ |
R8613 |
T13140 |
T13139 |
punct |
-,B |
R8614 |
T13141 |
T13116 |
auxpass |
was,injected |
R8615 |
T13142 |
T13116 |
prep |
into,injected |
R8616 |
T13143 |
T13144 |
det |
the,pronucleus |
R8617 |
T13144 |
T13142 |
pobj |
pronucleus,into |
R8618 |
T13145 |
T13144 |
prep |
of,pronucleus |
R8619 |
T13146 |
T13145 |
pobj |
oocytes,of |
R8620 |
T13147 |
T13146 |
acl |
obtained,oocytes |
R8621 |
T13148 |
T13147 |
prep |
from,obtained |
R8622 |
T13149 |
T13150 |
nmod |
DBA1,C57Bl |
R8623 |
T13150 |
T13152 |
nmod |
C57Bl,hybrids |
R8624 |
T13151 |
T13150 |
punct |
/,C57Bl |
R8625 |
T13152 |
T13148 |
pobj |
hybrids,from |
R8626 |
T13153 |
T13150 |
punct |
/,C57Bl |
R8627 |
T13154 |
T13150 |
nummod |
6,C57Bl |
R8628 |
T13155 |
T13152 |
compound |
F1,hybrids |
R8629 |
T13156 |
T13116 |
punct |
.,injected |
R8630 |
T13158 |
T13159 |
amod |
Positive,founders |
R8631 |
T13159 |
T13160 |
nsubjpass |
founders,backcrossed |
R8632 |
T13161 |
T13160 |
auxpass |
were,backcrossed |
R8633 |
T13162 |
T13160 |
prep |
into,backcrossed |
R8634 |
T13163 |
T13162 |
pobj |
C57Bl,into |
R8635 |
T13164 |
T13163 |
punct |
/,C57Bl |
R8636 |
T13165 |
T13163 |
nummod |
6,C57Bl |
R8637 |
T13166 |
T13160 |
prep |
for,backcrossed |
R8638 |
T13167 |
T13168 |
amod |
further,analysis |
R8639 |
T13168 |
T13166 |
pobj |
analysis,for |
R8640 |
T13169 |
T13160 |
punct |
.,backcrossed |
R8641 |
T13171 |
T13172 |
compound |
Plasmid,pnlacZ |
R8642 |
T13172 |
T13173 |
nsubjpass |
pnlacZ,constructed |
R8643 |
T13174 |
T13172 |
punct |
/,pnlacZ |
R8644 |
T13175 |
T13176 |
compound |
GFPGluR,B |
R8645 |
T13176 |
T13172 |
appos |
B,pnlacZ |
R8646 |
T13177 |
T13176 |
punct |
-,B |
R8647 |
T13178 |
T13173 |
auxpass |
was,constructed |
R8648 |
T13179 |
T13173 |
prep |
from,constructed |
R8649 |
T13180 |
T13181 |
compound |
pnlacZ,A |
R8650 |
T13181 |
T13179 |
pobj |
A,from |
R8651 |
T13182 |
T13181 |
punct |
/,A |
R8652 |
T13183 |
T13181 |
compound |
GFPGluR,A |
R8653 |
T13184 |
T13181 |
punct |
-,A |
R8654 |
T13185 |
T13186 |
punct |
[,87 |
R8655 |
T13186 |
T13181 |
parataxis |
87,A |
R8656 |
T13187 |
T13186 |
punct |
],87 |
R8657 |
T13188 |
T13173 |
prep |
by,constructed |
R8658 |
T13189 |
T13188 |
pcomp |
replacing,by |
R8659 |
T13190 |
T13191 |
compound |
GluR,A |
R8660 |
T13191 |
T13193 |
compound |
A,cDNA |
R8661 |
T13192 |
T13191 |
punct |
-,A |
R8662 |
T13193 |
T13189 |
dobj |
cDNA,replacing |
R8663 |
T13194 |
T13189 |
prep |
with,replacing |
R8664 |
T13195 |
T13196 |
det |
the,cDNA |
R8665 |
T13196 |
T13194 |
pobj |
cDNA,with |
R8666 |
T13197 |
T13196 |
compound |
rat,cDNA |
R8667 |
T13198 |
T13196 |
prep |
for,cDNA |
R8668 |
T13199 |
T13200 |
compound |
GluR,B |
R8669 |
T13200 |
T13198 |
pobj |
B,for |
R8670 |
T13201 |
T13200 |
punct |
-,B |
R8671 |
T13202 |
T13173 |
punct |
.,constructed |
R8672 |
T13204 |
T13205 |
amod |
Transgenic,protein |
R8673 |
T13205 |
T13209 |
compound |
protein,levels |
R8674 |
T13206 |
T13207 |
compound |
GFPGluR,B |
R8675 |
T13207 |
T13205 |
compound |
B,protein |
R8676 |
T13208 |
T13207 |
punct |
-,B |
R8677 |
T13209 |
T13210 |
nsubjpass |
levels,measured |
R8678 |
T13211 |
T13210 |
auxpass |
were,measured |
R8679 |
T13212 |
T13210 |
prep |
in,measured |
R8680 |
T13213 |
T13212 |
pobj |
hippocampus,in |
R8681 |
T13214 |
T13213 |
prep |
of,hippocampus |
R8682 |
T13215 |
T13216 |
compound |
TgOCN1,mice |
R8683 |
T13216 |
T13214 |
pobj |
mice,of |
R8684 |
T13217 |
T13218 |
advmod |
also,carrying |
R8685 |
T13218 |
T13216 |
acl |
carrying,mice |
R8686 |
T13219 |
T13220 |
det |
a,transgene |
R8687 |
T13220 |
T13218 |
dobj |
transgene,carrying |
R8688 |
T13221 |
T13220 |
prep |
for,transgene |
R8689 |
T13222 |
T13223 |
npadvmod |
forebrain,specific |
R8690 |
T13223 |
T13225 |
amod |
specific,expression |
R8691 |
T13224 |
T13223 |
punct |
-,specific |
R8692 |
T13225 |
T13221 |
pobj |
expression,for |
R8693 |
T13226 |
T13225 |
amod |
homogeneous,expression |
R8694 |
T13227 |
T13225 |
compound |
tTA,expression |
R8695 |
T13228 |
T13229 |
punct |
[,88 |
R8696 |
T13229 |
T13210 |
parataxis |
88,measured |
R8697 |
T13230 |
T13229 |
punct |
],88 |
R8698 |
T13231 |
T13210 |
punct |
.,measured |
R8699 |
T13401 |
T13402 |
amod |
Experimental,groups |
R8700 |
T13404 |
T13405 |
nsubjpass |
Mice,used |
R8701 |
T13406 |
T13404 |
amod |
heterozygous,Mice |
R8702 |
T13407 |
T13406 |
prep |
for,heterozygous |
R8703 |
T13408 |
T13407 |
pobj |
TgCre4,for |
R8704 |
T13409 |
T13406 |
cc |
and,heterozygous |
R8705 |
T13410 |
T13406 |
conj |
heterozygous,heterozygous |
R8706 |
T13411 |
T13410 |
prep |
for,heterozygous |
R8707 |
T13412 |
T13413 |
det |
the,cassette |
R8708 |
T13413 |
T13411 |
pobj |
cassette,for |
R8709 |
T13414 |
T13415 |
compound |
TK,neo |
R8710 |
T13415 |
T13413 |
compound |
neo,cassette |
R8711 |
T13416 |
T13415 |
punct |
-,neo |
R8712 |
T13417 |
T13410 |
prep |
in,heterozygous |
R8713 |
T13418 |
T13419 |
det |
the,allele |
R8714 |
T13419 |
T13417 |
pobj |
allele,in |
R8715 |
T13420 |
T13421 |
compound |
GluR,B |
R8716 |
T13421 |
T13419 |
compound |
B,allele |
R8717 |
T13422 |
T13421 |
punct |
-,B |
R8718 |
T13423 |
T13424 |
punct |
(,BΔECS |
R8719 |
T13424 |
T13419 |
parataxis |
BΔECS,allele |
R8720 |
T13425 |
T13424 |
compound |
GluR,BΔECS |
R8721 |
T13426 |
T13424 |
punct |
-,BΔECS |
R8722 |
T13427 |
T13424 |
punct |
:,BΔECS |
R8723 |
T13428 |
T13424 |
appos |
FB,BΔECS |
R8724 |
T13429 |
T13424 |
punct |
),BΔECS |
R8725 |
T13430 |
T13406 |
cc |
or,heterozygous |
R8726 |
T13431 |
T13406 |
conj |
homozygous,heterozygous |
R8727 |
T13432 |
T13431 |
prep |
for,homozygous |
R8728 |
T13433 |
T13434 |
det |
the,B |
R8729 |
T13434 |
T13432 |
pobj |
B,for |
R8730 |
T13435 |
T13434 |
amod |
floxed,B |
R8731 |
T13436 |
T13434 |
compound |
GluR,B |
R8732 |
T13437 |
T13434 |
punct |
-,B |
R8733 |
T13438 |
T13439 |
punct |
(,BΔFB |
R8734 |
T13439 |
T13434 |
parataxis |
BΔFB,B |
R8735 |
T13440 |
T13439 |
compound |
GluR,BΔFB |
R8736 |
T13441 |
T13439 |
punct |
-,BΔFB |
R8737 |
T13442 |
T13439 |
punct |
),BΔFB |
R8738 |
T13443 |
T13405 |
auxpass |
were,used |
R8739 |
T13444 |
T13405 |
prep |
in,used |
R8740 |
T13445 |
T13446 |
det |
the,experiments |
R8741 |
T13446 |
T13444 |
pobj |
experiments,in |
R8742 |
T13447 |
T13405 |
punct |
.,used |
R8743 |
T13449 |
T13450 |
det |
The,mice |
R8744 |
T13450 |
T13454 |
nsubj |
mice,were |
R8745 |
T13451 |
T13450 |
punct |
“,mice |
R8746 |
T13452 |
T13450 |
nmod |
rescue,mice |
R8747 |
T13453 |
T13450 |
punct |
”,mice |
R8748 |
T13455 |
T13450 |
punct |
(,mice |
R8749 |
T13456 |
T13457 |
compound |
GluR,BRescue |
R8750 |
T13457 |
T13450 |
appos |
BRescue,mice |
R8751 |
T13458 |
T13457 |
punct |
-,BRescue |
R8752 |
T13459 |
T13454 |
punct |
),were |
R8753 |
T13460 |
T13454 |
acomp |
positive,were |
R8754 |
T13461 |
T13460 |
prep |
for,positive |
R8755 |
T13462 |
T13461 |
pobj |
TgCre4,for |
R8756 |
T13463 |
T13460 |
punct |
", ",positive |
R8757 |
T13464 |
T13460 |
conj |
homozygous,positive |
R8758 |
T13465 |
T13464 |
prep |
for,homozygous |
R8759 |
T13466 |
T13467 |
det |
the,gene |
R8760 |
T13467 |
T13465 |
pobj |
gene,for |
R8761 |
T13468 |
T13467 |
amod |
floxed,gene |
R8762 |
T13469 |
T13470 |
compound |
GluR,B |
R8763 |
T13470 |
T13467 |
compound |
B,gene |
R8764 |
T13471 |
T13470 |
punct |
-,B |
R8765 |
T13472 |
T13464 |
punct |
", ",homozygous |
R8766 |
T13473 |
T13464 |
cc |
and,homozygous |
R8767 |
T13474 |
T13464 |
conj |
positive,homozygous |
R8768 |
T13475 |
T13474 |
prep |
for,positive |
R8769 |
T13476 |
T13477 |
det |
the,transgene |
R8770 |
T13477 |
T13475 |
pobj |
transgene,for |
R8771 |
T13478 |
T13479 |
npadvmod |
tet,sensitive |
R8772 |
T13479 |
T13477 |
amod |
sensitive,transgene |
R8773 |
T13480 |
T13479 |
punct |
-,sensitive |
R8774 |
T13481 |
T13477 |
compound |
responder,transgene |
R8775 |
T13482 |
T13477 |
appos |
TgOCN1,transgene |
R8776 |
T13483 |
T13475 |
cc |
and,for |
R8777 |
T13484 |
T13475 |
conj |
for,for |
R8778 |
T13485 |
T13486 |
det |
the,transgene |
R8779 |
T13486 |
T13484 |
pobj |
transgene,for |
R8780 |
T13487 |
T13488 |
npadvmod |
itTA,expressing |
R8781 |
T13488 |
T13486 |
amod |
expressing,transgene |
R8782 |
T13489 |
T13486 |
compound |
activator,transgene |
R8783 |
T13490 |
T13491 |
compound |
TgCN12,itTA |
R8784 |
T13491 |
T13486 |
appos |
itTA,transgene |
R8785 |
T13492 |
T13491 |
punct |
-,itTA |
R8786 |
T13493 |
T13454 |
punct |
.,were |
R8789 |
T13560 |
T13561 |
compound |
Control,groups |
R8790 |
T13563 |
T13564 |
compound |
Littermate,controls |
R8791 |
T13564 |
T13565 |
nsubjpass |
controls,used |
R8792 |
T13566 |
T13565 |
auxpass |
were,used |
R8793 |
T13567 |
T13565 |
prep |
in,used |
R8794 |
T13568 |
T13569 |
det |
all,experiments |
R8795 |
T13569 |
T13567 |
pobj |
experiments,in |
R8796 |
T13570 |
T13565 |
punct |
.,used |
R8797 |
T13572 |
T13573 |
nmod |
GluR,B |
R8798 |
T13573 |
T13575 |
nmod |
B,mice |
R8799 |
T13574 |
T13573 |
punct |
-,B |
R8800 |
T13575 |
T13579 |
nsubjpass |
mice,used |
R8801 |
T13576 |
T13573 |
punct |
+,B |
R8802 |
T13577 |
T13573 |
punct |
/,B |
R8803 |
T13578 |
T13573 |
punct |
+,B |
R8804 |
T13580 |
T13579 |
auxpass |
were,used |
R8805 |
T13581 |
T13579 |
prep |
as,used |
R8806 |
T13582 |
T13581 |
pobj |
controls,as |
R8807 |
T13583 |
T13579 |
prep |
in,used |
R8808 |
T13584 |
T13585 |
det |
the,task |
R8809 |
T13585 |
T13583 |
pobj |
task,in |
R8810 |
T13586 |
T13585 |
acl |
described,task |
R8811 |
T13587 |
T13586 |
prep |
in,described |
R8812 |
T13588 |
T13587 |
pobj |
Figure,in |
R8813 |
T13589 |
T13588 |
nummod |
1,Figure |
R8814 |
T13590 |
T13579 |
punct |
.,used |
R8815 |
T13592 |
T13593 |
nmod |
GluR,B |
R8816 |
T13593 |
T13595 |
nmod |
B,mice |
R8817 |
T13594 |
T13593 |
punct |
-,B |
R8818 |
T13595 |
T13611 |
nsubjpass |
mice,used |
R8819 |
T13596 |
T13593 |
punct |
+,B |
R8820 |
T13597 |
T13593 |
punct |
/,B |
R8821 |
T13598 |
T13593 |
appos |
2lox,B |
R8822 |
T13599 |
T13593 |
cc |
and,B |
R8823 |
T13600 |
T13601 |
compound |
GluR,B2lox |
R8824 |
T13601 |
T13593 |
conj |
B2lox,B |
R8825 |
T13602 |
T13601 |
punct |
-,B2lox |
R8826 |
T13603 |
T13601 |
punct |
/,B2lox |
R8827 |
T13604 |
T13601 |
appos |
2lox,B2lox |
R8828 |
T13605 |
T13593 |
punct |
(,B |
R8829 |
T13606 |
T13607 |
advmod |
both,negative |
R8830 |
T13607 |
T13593 |
relcl |
negative,B |
R8831 |
T13608 |
T13607 |
prep |
for,negative |
R8832 |
T13609 |
T13608 |
pobj |
TgCre4,for |
R8833 |
T13610 |
T13593 |
punct |
),B |
R8834 |
T13612 |
T13611 |
auxpass |
were,used |
R8835 |
T13613 |
T13611 |
prep |
as,used |
R8836 |
T13614 |
T13613 |
pobj |
controls,as |
R8837 |
T13615 |
T13611 |
prep |
in,used |
R8838 |
T13616 |
T13615 |
pobj |
experiments,in |
R8839 |
T13617 |
T13616 |
acl |
described,experiments |
R8840 |
T13618 |
T13617 |
prep |
in,described |
R8841 |
T13619 |
T13620 |
nmod |
Figures,2 |
R8842 |
T13620 |
T13618 |
pobj |
2,in |
R8843 |
T13621 |
T13620 |
punct |
", ",2 |
R8844 |
T13622 |
T13620 |
conj |
4,2 |
R8845 |
T13623 |
T13622 |
punct |
", ",4 |
R8846 |
T13624 |
T13622 |
cc |
and,4 |
R8847 |
T13625 |
T13622 |
conj |
6,4 |
R8848 |
T13626 |
T13611 |
punct |
.,used |
R8849 |
T13628 |
T13629 |
prep |
For,used |
R8850 |
T13630 |
T13631 |
det |
the,experiments |
R8851 |
T13631 |
T13628 |
pobj |
experiments,For |
R8852 |
T13632 |
T13633 |
compound |
GluR,BRescue |
R8853 |
T13633 |
T13631 |
compound |
BRescue,experiments |
R8854 |
T13634 |
T13633 |
punct |
-,BRescue |
R8855 |
T13635 |
T13636 |
punct |
(,Figure |
R8856 |
T13636 |
T13631 |
parataxis |
Figure,experiments |
R8857 |
T13637 |
T13636 |
nummod |
6,Figure |
R8858 |
T13638 |
T13636 |
punct |
),Figure |
R8859 |
T13639 |
T13629 |
punct |
", ",used |
R8860 |
T13640 |
T13629 |
nsubjpass |
controls,used |
R8861 |
T13641 |
T13640 |
amod |
positive,controls |
R8862 |
T13642 |
T13641 |
prep |
for,positive |
R8863 |
T13643 |
T13644 |
preconj |
either,itTA |
R8864 |
T13644 |
T13642 |
pobj |
itTA,for |
R8865 |
T13645 |
T13644 |
compound |
TgCN12,itTA |
R8866 |
T13646 |
T13644 |
punct |
-,itTA |
R8867 |
T13647 |
T13644 |
cc |
or,itTA |
R8868 |
T13648 |
T13644 |
conj |
TgOCN1,itTA |
R8869 |
T13649 |
T13640 |
prep |
in,controls |
R8870 |
T13650 |
T13651 |
det |
a,background |
R8871 |
T13651 |
T13649 |
pobj |
background,in |
R8872 |
T13652 |
T13653 |
nmod |
GluR,B |
R8873 |
T13653 |
T13651 |
nmod |
B,background |
R8874 |
T13654 |
T13653 |
punct |
-,B |
R8875 |
T13655 |
T13653 |
punct |
+,B |
R8876 |
T13656 |
T13653 |
punct |
/,B |
R8877 |
T13657 |
T13653 |
appos |
2lox,B |
R8878 |
T13658 |
T13653 |
cc |
and,B |
R8879 |
T13659 |
T13660 |
compound |
GluR,B2lox |
R8880 |
T13660 |
T13653 |
conj |
B2lox,B |
R8881 |
T13661 |
T13660 |
punct |
-,B2lox |
R8882 |
T13662 |
T13660 |
punct |
/,B2lox |
R8883 |
T13663 |
T13660 |
appos |
2lox,B2lox |
R8884 |
T13664 |
T13653 |
punct |
(,B |
R8885 |
T13665 |
T13666 |
advmod |
both,negative |
R8886 |
T13666 |
T13653 |
relcl |
negative,B |
R8887 |
T13667 |
T13666 |
prep |
for,negative |
R8888 |
T13668 |
T13667 |
pobj |
TgCre4,for |
R8889 |
T13669 |
T13653 |
punct |
),B |
R8890 |
T13670 |
T13629 |
auxpass |
were,used |
R8891 |
T13671 |
T13629 |
punct |
.,used |
R8892 |
T13713 |
T13714 |
nsubjpass |
Mice,selected |
R8893 |
T13715 |
T13714 |
auxpass |
were,selected |
R8894 |
T13716 |
T13714 |
prep |
by,selected |
R8895 |
T13717 |
T13716 |
pobj |
PCR,by |
R8896 |
T13718 |
T13717 |
prep |
of,PCR |
R8897 |
T13719 |
T13720 |
compound |
mouse,tail |
R8898 |
T13720 |
T13722 |
compound |
tail,DNA |
R8899 |
T13721 |
T13720 |
punct |
-,tail |
R8900 |
T13722 |
T13718 |
pobj |
DNA,of |
R8901 |
T13723 |
T13722 |
prep |
with,DNA |
R8902 |
T13724 |
T13725 |
amod |
specific,primers |
R8903 |
T13725 |
T13723 |
pobj |
primers,with |
R8904 |
T13726 |
T13727 |
mark |
as,described |
R8905 |
T13727 |
T13714 |
advcl |
described,selected |
R8906 |
T13728 |
T13727 |
advmod |
below,described |
R8907 |
T13729 |
T13714 |
punct |
.,selected |
R8908 |
T13731 |
T13732 |
dep |
Indicated,are |
R8909 |
T13733 |
T13734 |
det |
the,sequences |
R8910 |
T13734 |
T13732 |
nsubj |
sequences,are |
R8911 |
T13735 |
T13734 |
cc |
and,sequences |
R8912 |
T13736 |
T13737 |
det |
the,length |
R8913 |
T13737 |
T13734 |
conj |
length,sequences |
R8914 |
T13738 |
T13737 |
amod |
approximate,length |
R8915 |
T13739 |
T13734 |
prep |
of,sequences |
R8916 |
T13740 |
T13741 |
det |
the,fragments |
R8917 |
T13741 |
T13739 |
pobj |
fragments,of |
R8918 |
T13742 |
T13741 |
amod |
amplified,fragments |
R8919 |
T13743 |
T13741 |
compound |
DNA,fragments |
R8920 |
T13744 |
T13732 |
punct |
.,are |
R8921 |
T13747 |
T13746 |
punct |
: ,TgCre4 |
R8922 |
T13748 |
T13749 |
dep |
rspCre1,bp |
R8923 |
T13749 |
T13746 |
dep |
bp,TgCre4 |
R8924 |
T13750 |
T13751 |
punct |
(,3 |
R8925 |
T13751 |
T13748 |
parataxis |
3,rspCre1 |
R8926 |
T13752 |
T13751 |
dep |
5,3 |
R8927 |
T13753 |
T13752 |
punct |
′,5 |
R8928 |
T13754 |
T13751 |
punct |
-,3 |
R8929 |
T13755 |
T13751 |
dep |
ACCAGGTTCGTTCACTCATGG,3 |
R8930 |
T13756 |
T13751 |
punct |
-,3 |
R8931 |
T13757 |
T13751 |
punct |
′,3 |
R8932 |
T13758 |
T13751 |
punct |
),3 |
R8933 |
T13759 |
T13748 |
cc |
and,rspCre1 |
R8934 |
T13760 |
T13748 |
conj |
rspCre2,rspCre1 |
R8935 |
T13761 |
T13762 |
punct |
(,AGGCTAAGTGCCTTCTCTACAC |
R8936 |
T13762 |
T13760 |
parataxis |
AGGCTAAGTGCCTTCTCTACAC,rspCre2 |
R8937 |
T13763 |
T13762 |
nummod |
5,AGGCTAAGTGCCTTCTCTACAC |
R8938 |
T13764 |
T13763 |
punct |
′,5 |
R8939 |
T13765 |
T13762 |
punct |
-,AGGCTAAGTGCCTTCTCTACAC |
R8940 |
T13766 |
T13762 |
punct |
-,AGGCTAAGTGCCTTCTCTACAC |
R8941 |
T13767 |
T13762 |
nummod |
3,AGGCTAAGTGCCTTCTCTACAC |
R8942 |
T13768 |
T13762 |
punct |
′,AGGCTAAGTGCCTTCTCTACAC |
R8943 |
T13769 |
T13762 |
punct |
),AGGCTAAGTGCCTTCTCTACAC |
R8944 |
T13770 |
T13749 |
punct |
", ",bp |
R8945 |
T13771 |
T13749 |
nummod |
200,bp |
R8946 |
T13772 |
T13749 |
nmod |
basepairs,bp |
R8947 |
T13773 |
T13749 |
punct |
(,bp |
R8948 |
T13774 |
T13746 |
punct |
),TgCre4 |
R8949 |
T13775 |
T13746 |
punct |
.,TgCre4 |
R8950 |
T13777 |
T13778 |
compound |
GluR,Bneo |
R8951 |
T13778 |
T13780 |
dep |
Bneo,MH60 |
R8952 |
T13779 |
T13778 |
punct |
-,Bneo |
R8953 |
T13781 |
T13780 |
punct |
: ,MH60 |
R8954 |
T13782 |
T13783 |
punct |
(,CACTCACAGCAATGAAGCAGGAC |
R8955 |
T13783 |
T13780 |
parataxis |
CACTCACAGCAATGAAGCAGGAC,MH60 |
R8956 |
T13784 |
T13783 |
nummod |
5,CACTCACAGCAATGAAGCAGGAC |
R8957 |
T13785 |
T13784 |
punct |
′,5 |
R8958 |
T13786 |
T13783 |
punct |
-,CACTCACAGCAATGAAGCAGGAC |
R8959 |
T13787 |
T13783 |
punct |
-,CACTCACAGCAATGAAGCAGGAC |
R8960 |
T13788 |
T13783 |
nummod |
3,CACTCACAGCAATGAAGCAGGAC |
R8961 |
T13789 |
T13783 |
punct |
′,CACTCACAGCAATGAAGCAGGAC |
R8962 |
T13790 |
T13783 |
punct |
),CACTCACAGCAATGAAGCAGGAC |
R8963 |
T13791 |
T13780 |
punct |
", ",MH60 |
R8964 |
T13792 |
T13780 |
conj |
MH53a,MH60 |
R8965 |
T13793 |
T13794 |
punct |
(,GAATGTTGATCATGTGTTTCCCTG |
R8966 |
T13794 |
T13792 |
parataxis |
GAATGTTGATCATGTGTTTCCCTG,MH53a |
R8967 |
T13795 |
T13794 |
nummod |
5,GAATGTTGATCATGTGTTTCCCTG |
R8968 |
T13796 |
T13795 |
punct |
′,5 |
R8969 |
T13797 |
T13794 |
punct |
-,GAATGTTGATCATGTGTTTCCCTG |
R8970 |
T13798 |
T13794 |
punct |
-,GAATGTTGATCATGTGTTTCCCTG |
R8971 |
T13799 |
T13794 |
nummod |
3,GAATGTTGATCATGTGTTTCCCTG |
R8972 |
T13800 |
T13794 |
punct |
′,GAATGTTGATCATGTGTTTCCCTG |
R8973 |
T13801 |
T13794 |
punct |
),GAATGTTGATCATGTGTTTCCCTG |
R8974 |
T13802 |
T13792 |
punct |
", ",MH53a |
R8975 |
T13803 |
T13792 |
cc |
and,MH53a |
R8976 |
T13804 |
T13792 |
conj |
MH117,MH53a |
R8977 |
T13805 |
T13806 |
punct |
(,GTTCGAATTCGCCAATGACAAGACG |
R8978 |
T13806 |
T13804 |
parataxis |
GTTCGAATTCGCCAATGACAAGACG,MH117 |
R8979 |
T13807 |
T13806 |
nummod |
5,GTTCGAATTCGCCAATGACAAGACG |
R8980 |
T13808 |
T13807 |
punct |
′,5 |
R8981 |
T13809 |
T13806 |
punct |
-,GTTCGAATTCGCCAATGACAAGACG |
R8982 |
T13810 |
T13806 |
punct |
-,GTTCGAATTCGCCAATGACAAGACG |
R8983 |
T13811 |
T13806 |
nummod |
3,GTTCGAATTCGCCAATGACAAGACG |
R8984 |
T13812 |
T13806 |
punct |
′,GTTCGAATTCGCCAATGACAAGACG |
R8985 |
T13813 |
T13806 |
punct |
),GTTCGAATTCGCCAATGACAAGACG |
R8986 |
T13814 |
T13780 |
punct |
", ",MH60 |
R8987 |
T13815 |
T13816 |
amod |
wild,type |
R8988 |
T13816 |
T13818 |
dep |
type,bp |
R8989 |
T13817 |
T13816 |
punct |
-,type |
R8990 |
T13818 |
T13780 |
conj |
bp,MH60 |
R8991 |
T13819 |
T13818 |
punct |
: ,bp |
R8992 |
T13820 |
T13818 |
nummod |
500,bp |
R8993 |
T13821 |
T13818 |
cc |
and,bp |
R8994 |
T13822 |
T13823 |
dep |
mutant,bp |
R8995 |
T13823 |
T13818 |
conj |
bp,bp |
R8996 |
T13824 |
T13823 |
punct |
: ,bp |
R8997 |
T13825 |
T13823 |
nummod |
400,bp |
R8998 |
T13826 |
T13823 |
punct |
.,bp |
R8999 |
T13828 |
T13829 |
compound |
GluR,B2lox |
R9000 |
T13829 |
T13831 |
dep |
B2lox,VM12 |
R9001 |
T13830 |
T13829 |
punct |
-,B2lox |
R9002 |
T13832 |
T13831 |
punct |
: ,VM12 |
R9003 |
T13833 |
T13834 |
punct |
(,GCGTAAGCCTGTGA AATACCTG |
R9004 |
T13834 |
T13831 |
parataxis |
GCGTAAGCCTGTGA AATACCTG,VM12 |
R9005 |
T13835 |
T13834 |
nummod |
5,GCGTAAGCCTGTGA AATACCTG |
R9006 |
T13836 |
T13835 |
punct |
′,5 |
R9007 |
T13837 |
T13834 |
punct |
-,GCGTAAGCCTGTGA AATACCTG |
R9008 |
T13838 |
T13834 |
punct |
-,GCGTAAGCCTGTGA AATACCTG |
R9009 |
T13839 |
T13834 |
nummod |
3,GCGTAAGCCTGTGA AATACCTG |
R9010 |
T13840 |
T13834 |
punct |
′,GCGTAAGCCTGTGA AATACCTG |
R9011 |
T13841 |
T13834 |
punct |
),GCGTAAGCCTGTGA AATACCTG |
R9012 |
T13842 |
T13831 |
cc |
and,VM12 |
R9013 |
T13843 |
T13831 |
conj |
VM10,VM12 |
R9014 |
T13844 |
T13845 |
punct |
(,GTTGTCTAACAAGTTGTTGACC |
R9015 |
T13845 |
T13843 |
parataxis |
GTTGTCTAACAAGTTGTTGACC,VM10 |
R9016 |
T13846 |
T13845 |
nummod |
5,GTTGTCTAACAAGTTGTTGACC |
R9017 |
T13847 |
T13846 |
punct |
′,5 |
R9018 |
T13848 |
T13845 |
punct |
-,GTTGTCTAACAAGTTGTTGACC |
R9019 |
T13849 |
T13845 |
punct |
-,GTTGTCTAACAAGTTGTTGACC |
R9020 |
T13850 |
T13845 |
nummod |
3,GTTGTCTAACAAGTTGTTGACC |
R9021 |
T13851 |
T13845 |
punct |
′,GTTGTCTAACAAGTTGTTGACC |
R9022 |
T13852 |
T13845 |
punct |
),GTTGTCTAACAAGTTGTTGACC |
R9023 |
T13853 |
T13831 |
punct |
", ",VM12 |
R9024 |
T13854 |
T13855 |
amod |
wild,type |
R9025 |
T13855 |
T13857 |
dep |
type,bp |
R9026 |
T13856 |
T13855 |
punct |
-,type |
R9027 |
T13857 |
T13831 |
conj |
bp,VM12 |
R9028 |
T13858 |
T13857 |
punct |
: ,bp |
R9029 |
T13859 |
T13857 |
nummod |
250,bp |
R9030 |
T13860 |
T13857 |
cc |
and,bp |
R9031 |
T13861 |
T13862 |
dep |
mutant,bp |
R9032 |
T13862 |
T13857 |
conj |
bp,bp |
R9033 |
T13863 |
T13862 |
punct |
: ,bp |
R9034 |
T13864 |
T13862 |
nummod |
350,bp |
R9035 |
T13865 |
T13862 |
punct |
.,bp |
R9036 |
T13868 |
T13867 |
punct |
: ,TgOCN1 |
R9037 |
T13869 |
T13870 |
dep |
VM4,bp |
R9038 |
T13870 |
T13867 |
dep |
bp,TgOCN1 |
R9039 |
T13871 |
T13872 |
punct |
(,CTCCCAGACAACCATTACCTGTCC |
R9040 |
T13872 |
T13869 |
parataxis |
CTCCCAGACAACCATTACCTGTCC,VM4 |
R9041 |
T13873 |
T13872 |
nummod |
5,CTCCCAGACAACCATTACCTGTCC |
R9042 |
T13874 |
T13873 |
punct |
′,5 |
R9043 |
T13875 |
T13872 |
punct |
-,CTCCCAGACAACCATTACCTGTCC |
R9044 |
T13876 |
T13872 |
punct |
-,CTCCCAGACAACCATTACCTGTCC |
R9045 |
T13877 |
T13872 |
nummod |
3,CTCCCAGACAACCATTACCTGTCC |
R9046 |
T13878 |
T13872 |
punct |
′,CTCCCAGACAACCATTACCTGTCC |
R9047 |
T13879 |
T13872 |
punct |
),CTCCCAGACAACCATTACCTGTCC |
R9048 |
T13880 |
T13869 |
cc |
and,VM4 |
R9049 |
T13881 |
T13882 |
compound |
GluR,B882BST |
R9050 |
T13882 |
T13869 |
conj |
B882BST,VM4 |
R9051 |
T13883 |
T13882 |
punct |
-,B882BST |
R9052 |
T13884 |
T13885 |
punct |
(,CGAAGTATACTTAATTGTCGCTGTGTG |
R9053 |
T13885 |
T13882 |
parataxis |
CGAAGTATACTTAATTGTCGCTGTGTG,B882BST |
R9054 |
T13886 |
T13885 |
nummod |
5,CGAAGTATACTTAATTGTCGCTGTGTG |
R9055 |
T13887 |
T13886 |
punct |
′,5 |
R9056 |
T13888 |
T13885 |
punct |
-,CGAAGTATACTTAATTGTCGCTGTGTG |
R9057 |
T13889 |
T13885 |
punct |
-,CGAAGTATACTTAATTGTCGCTGTGTG |
R9058 |
T13890 |
T13885 |
nummod |
3,CGAAGTATACTTAATTGTCGCTGTGTG |
R9059 |
T13891 |
T13885 |
punct |
′,CGAAGTATACTTAATTGTCGCTGTGTG |
R9060 |
T13892 |
T13885 |
punct |
),CGAAGTATACTTAATTGTCGCTGTGTG |
R9061 |
T13893 |
T13870 |
punct |
", ",bp |
R9062 |
T13894 |
T13870 |
nummod |
600,bp |
R9063 |
T13895 |
T13867 |
punct |
.,TgOCN1 |
R9064 |
T13897 |
T13898 |
compound |
TgCN12,itTA |
R9065 |
T13899 |
T13898 |
punct |
-,itTA |
R9066 |
T13900 |
T13898 |
punct |
: ,itTA |
R9067 |
T13901 |
T13902 |
dep |
htTA1,bp |
R9068 |
T13902 |
T13898 |
dep |
bp,itTA |
R9069 |
T13903 |
T13904 |
punct |
(,AGAGCAAAGTCATCAACTCTG |
R9070 |
T13904 |
T13901 |
parataxis |
AGAGCAAAGTCATCAACTCTG,htTA1 |
R9071 |
T13905 |
T13904 |
nummod |
5,AGAGCAAAGTCATCAACTCTG |
R9072 |
T13906 |
T13905 |
punct |
′,5 |
R9073 |
T13907 |
T13904 |
punct |
-,AGAGCAAAGTCATCAACTCTG |
R9074 |
T13908 |
T13904 |
punct |
-,AGAGCAAAGTCATCAACTCTG |
R9075 |
T13909 |
T13904 |
nummod |
3,AGAGCAAAGTCATCAACTCTG |
R9076 |
T13910 |
T13904 |
punct |
′,AGAGCAAAGTCATCAACTCTG |
R9077 |
T13911 |
T13904 |
punct |
),AGAGCAAAGTCATCAACTCTG |
R9078 |
T13912 |
T13901 |
cc |
and,htTA1 |
R9079 |
T13913 |
T13901 |
conj |
htTA2,htTA1 |
R9080 |
T13914 |
T13915 |
punct |
(,GTGAGAGCCAGACTCACATTTCA |
R9081 |
T13915 |
T13913 |
parataxis |
GTGAGAGCCAGACTCACATTTCA,htTA2 |
R9082 |
T13916 |
T13915 |
nummod |
5,GTGAGAGCCAGACTCACATTTCA |
R9083 |
T13917 |
T13916 |
punct |
′,5 |
R9084 |
T13918 |
T13915 |
punct |
-,GTGAGAGCCAGACTCACATTTCA |
R9085 |
T13919 |
T13915 |
punct |
-,GTGAGAGCCAGACTCACATTTCA |
R9086 |
T13920 |
T13915 |
nummod |
3,GTGAGAGCCAGACTCACATTTCA |
R9087 |
T13921 |
T13915 |
punct |
′,GTGAGAGCCAGACTCACATTTCA |
R9088 |
T13922 |
T13915 |
punct |
),GTGAGAGCCAGACTCACATTTCA |
R9089 |
T13923 |
T13902 |
punct |
", ",bp |
R9090 |
T13924 |
T13902 |
nummod |
"1,000",bp |
R9091 |
T13925 |
T13898 |
punct |
.,itTA |
R9092 |
T13970 |
T13971 |
compound |
Southern,blot |
R9093 |
T13971 |
T13972 |
compound |
blot,analysis |
R9094 |
T13974 |
T13975 |
amod |
Genomic,DNA |
R9095 |
T13975 |
T13976 |
nsubjpass |
DNA,digested |
R9096 |
T13977 |
T13975 |
prep |
from,DNA |
R9097 |
T13978 |
T13979 |
compound |
mouse,tail |
R9098 |
T13979 |
T13977 |
pobj |
tail,from |
R9099 |
T13980 |
T13979 |
punct |
-,tail |
R9100 |
T13981 |
T13979 |
punct |
/,tail |
R9101 |
T13982 |
T13979 |
appos |
liver,tail |
R9102 |
T13983 |
T13976 |
auxpass |
was,digested |
R9103 |
T13984 |
T13976 |
prep |
with,digested |
R9104 |
T13985 |
T13986 |
compound |
restriction,BglII |
R9105 |
T13986 |
T13984 |
pobj |
BglII,with |
R9106 |
T13987 |
T13986 |
compound |
enzyme,BglII |
R9107 |
T13988 |
T13989 |
punct |
(,NEB |
R9108 |
T13989 |
T13986 |
parataxis |
NEB,BglII |
R9109 |
T13990 |
T13989 |
punct |
),NEB |
R9110 |
T13991 |
T13976 |
punct |
", ",digested |
R9111 |
T13992 |
T13976 |
cc |
and,digested |
R9112 |
T13993 |
T13994 |
det |
the,blot |
R9113 |
T13994 |
T13996 |
nsubjpass |
blot,done |
R9114 |
T13995 |
T13994 |
compound |
Southern,blot |
R9115 |
T13996 |
T13976 |
conj |
done,digested |
R9116 |
T13997 |
T13996 |
auxpass |
was,done |
R9117 |
T13998 |
T13996 |
prep |
with,done |
R9118 |
T13999 |
T14000 |
det |
a,probe |
R9119 |
T14000 |
T13998 |
pobj |
probe,with |
R9120 |
T14001 |
T14002 |
nummod |
320,bp |
R9121 |
T14002 |
T14000 |
compound |
bp,probe |
R9122 |
T14003 |
T14002 |
punct |
-,bp |
R9123 |
T14004 |
T14005 |
punct |
(,integ |
R9124 |
T14005 |
T14000 |
parataxis |
integ,probe |
R9125 |
T14006 |
T14005 |
punct |
“,integ |
R9126 |
T14007 |
T14005 |
punct |
”,integ |
R9127 |
T14008 |
T14005 |
punct |
),integ |
R9128 |
T14009 |
T14000 |
acl |
obtained,probe |
R9129 |
T14010 |
T14009 |
prep |
by,obtained |
R9130 |
T14011 |
T14012 |
nsubj |
PCR,detecting |
R9131 |
T14012 |
T14010 |
pcomp |
detecting,by |
R9132 |
T14013 |
T14014 |
det |
the,promoter |
R9133 |
T14014 |
T14012 |
dobj |
promoter,detecting |
R9134 |
T14015 |
T14014 |
compound |
αCaMKII,promoter |
R9135 |
T14016 |
T13996 |
punct |
.,done |
R9136 |
T14050 |
T14051 |
nsubjpass |
Histochemistry,performed |
R9137 |
T14051 |
T14053 |
ccomp |
performed,used |
R9138 |
T14052 |
T14051 |
auxpass |
was,performed |
R9139 |
T14054 |
T14055 |
mark |
as,described |
R9140 |
T14055 |
T14051 |
advcl |
described,performed |
R9141 |
T14056 |
T14055 |
advmod |
previously,described |
R9142 |
T14057 |
T14058 |
punct |
[,89 |
R9143 |
T14058 |
T14055 |
parataxis |
89,described |
R9144 |
T14059 |
T14058 |
punct |
],89 |
R9145 |
T14060 |
T14051 |
punct |
", ",performed |
R9146 |
T14061 |
T14051 |
prep |
with,performed |
R9147 |
T14062 |
T14063 |
det |
the,exceptions |
R9148 |
T14063 |
T14061 |
pobj |
exceptions,with |
R9149 |
T14064 |
T14063 |
amod |
following,exceptions |
R9150 |
T14065 |
T14053 |
punct |
: ,used |
R9151 |
T14066 |
T14067 |
amod |
Coronal,slices |
R9152 |
T14067 |
T14053 |
nsubjpass |
slices,used |
R9153 |
T14068 |
T14069 |
quantmod |
70,100 |
R9154 |
T14069 |
T14072 |
nummod |
100,μm |
R9155 |
T14070 |
T14069 |
punct |
-,100 |
R9156 |
T14071 |
T14069 |
quantmod |
to,100 |
R9157 |
T14072 |
T14067 |
compound |
μm,slices |
R9158 |
T14073 |
T14072 |
punct |
-,μm |
R9159 |
T14074 |
T14067 |
compound |
vibratome,slices |
R9160 |
T14075 |
T14053 |
auxpass |
were,used |
R9161 |
T14076 |
T14053 |
prep |
for,used |
R9162 |
T14077 |
T14076 |
pobj |
immunohistochemistry,for |
R9163 |
T14078 |
T14053 |
prep |
with,used |
R9164 |
T14079 |
T14080 |
nmod |
GluR,B |
R9165 |
T14080 |
T14082 |
nmod |
B,antibodies |
R9166 |
T14081 |
T14080 |
punct |
-,B |
R9167 |
T14082 |
T14078 |
pobj |
antibodies,with |
R9168 |
T14083 |
T14084 |
punct |
(,Chemicon |
R9169 |
T14084 |
T14080 |
parataxis |
Chemicon,B |
R9170 |
T14085 |
T14084 |
dep |
1,Chemicon |
R9171 |
T14086 |
T14087 |
punct |
:,60 |
R9172 |
T14087 |
T14085 |
prep |
60,1 |
R9173 |
T14088 |
T14084 |
punct |
", ",Chemicon |
R9174 |
T14089 |
T14084 |
amod |
polyclonal,Chemicon |
R9175 |
T14090 |
T14084 |
punct |
;,Chemicon |
R9176 |
T14091 |
T14084 |
punct |
", ",Chemicon |
R9177 |
T14092 |
T14084 |
npadvmod |
Temecula,Chemicon |
R9178 |
T14093 |
T14084 |
punct |
", ",Chemicon |
R9179 |
T14094 |
T14084 |
npadvmod |
California,Chemicon |
R9180 |
T14095 |
T14084 |
punct |
", ",Chemicon |
R9181 |
T14096 |
T14097 |
compound |
United,States |
R9182 |
T14097 |
T14084 |
npadvmod |
States,Chemicon |
R9183 |
T14098 |
T14084 |
punct |
),Chemicon |
R9184 |
T14099 |
T14080 |
punct |
", ",B |
R9185 |
T14100 |
T14080 |
conj |
GFP,B |
R9186 |
T14101 |
T14102 |
punct |
(,MobiTech |
R9187 |
T14102 |
T14100 |
parataxis |
MobiTech,GFP |
R9188 |
T14103 |
T14102 |
dep |
1,MobiTech |
R9189 |
T14104 |
T14105 |
punct |
:,"8,000" |
R9190 |
T14105 |
T14103 |
prep |
"8,000",1 |
R9191 |
T14106 |
T14102 |
punct |
", ",MobiTech |
R9192 |
T14107 |
T14102 |
amod |
polyclonal,MobiTech |
R9193 |
T14108 |
T14102 |
punct |
;,MobiTech |
R9194 |
T14109 |
T14102 |
punct |
", ",MobiTech |
R9195 |
T14110 |
T14102 |
npadvmod |
Göttingen,MobiTech |
R9196 |
T14111 |
T14102 |
punct |
", ",MobiTech |
R9197 |
T14112 |
T14102 |
npadvmod |
Germany,MobiTech |
R9198 |
T14113 |
T14102 |
punct |
),MobiTech |
R9199 |
T14114 |
T14100 |
punct |
", ",GFP |
R9200 |
T14115 |
T14100 |
cc |
and,GFP |
R9201 |
T14116 |
T14100 |
conj |
Cre,GFP |
R9202 |
T14117 |
T14118 |
punct |
(,BAbCO |
R9203 |
T14118 |
T14116 |
parataxis |
BAbCO,Cre |
R9204 |
T14119 |
T14118 |
dep |
1,BAbCO |
R9205 |
T14120 |
T14121 |
punct |
:,"8,000" |
R9206 |
T14121 |
T14119 |
prep |
"8,000",1 |
R9207 |
T14122 |
T14118 |
punct |
", ",BAbCO |
R9208 |
T14123 |
T14118 |
amod |
polyclonal,BAbCO |
R9209 |
T14124 |
T14118 |
punct |
;,BAbCO |
R9210 |
T14125 |
T14118 |
punct |
", ",BAbCO |
R9211 |
T14126 |
T14118 |
npadvmod |
Berkeley,BAbCO |
R9212 |
T14127 |
T14118 |
punct |
", ",BAbCO |
R9213 |
T14128 |
T14118 |
npadvmod |
California,BAbCO |
R9214 |
T14129 |
T14118 |
punct |
", ",BAbCO |
R9215 |
T14130 |
T14131 |
compound |
United,States |
R9216 |
T14131 |
T14118 |
npadvmod |
States,BAbCO |
R9217 |
T14132 |
T14118 |
punct |
),BAbCO |
R9218 |
T14133 |
T14082 |
amod |
primary,antibodies |
R9219 |
T14134 |
T14082 |
punct |
", ",antibodies |
R9220 |
T14135 |
T14082 |
cc |
and,antibodies |
R9221 |
T14136 |
T14137 |
npadvmod |
FITC,coupled |
R9222 |
T14137 |
T14139 |
amod |
coupled,antibodies |
R9223 |
T14138 |
T14137 |
punct |
-,coupled |
R9224 |
T14139 |
T14082 |
conj |
antibodies,antibodies |
R9225 |
T14140 |
T14141 |
punct |
(,Dianova |
R9226 |
T14141 |
T14137 |
parataxis |
Dianova,coupled |
R9227 |
T14142 |
T14141 |
dep |
1,Dianova |
R9228 |
T14143 |
T14144 |
punct |
:,200 |
R9229 |
T14144 |
T14142 |
prep |
200,1 |
R9230 |
T14145 |
T14141 |
punct |
;,Dianova |
R9231 |
T14146 |
T14141 |
punct |
", ",Dianova |
R9232 |
T14147 |
T14141 |
npadvmod |
Hamburg,Dianova |
R9233 |
T14148 |
T14141 |
punct |
", ",Dianova |
R9234 |
T14149 |
T14141 |
npadvmod |
Germany,Dianova |
R9235 |
T14150 |
T14141 |
punct |
),Dianova |
R9236 |
T14151 |
T14137 |
cc |
and,coupled |
R9237 |
T14152 |
T14153 |
npadvmod |
peroxidase,coupled |
R9238 |
T14153 |
T14137 |
conj |
coupled,coupled |
R9239 |
T14154 |
T14153 |
punct |
-,coupled |
R9240 |
T14155 |
T14156 |
punct |
(,Vector |
R9241 |
T14156 |
T14153 |
parataxis |
Vector,coupled |
R9242 |
T14157 |
T14156 |
dep |
1,Vector |
R9243 |
T14158 |
T14159 |
punct |
:,600 |
R9244 |
T14159 |
T14157 |
prep |
600,1 |
R9245 |
T14160 |
T14156 |
punct |
;,Vector |
R9246 |
T14161 |
T14156 |
punct |
", ",Vector |
R9247 |
T14162 |
T14156 |
npadvmod |
Burlingame,Vector |
R9248 |
T14163 |
T14156 |
punct |
", ",Vector |
R9249 |
T14164 |
T14156 |
npadvmod |
California,Vector |
R9250 |
T14165 |
T14156 |
punct |
", ",Vector |
R9251 |
T14166 |
T14167 |
compound |
United,States |
R9252 |
T14167 |
T14156 |
npadvmod |
States,Vector |
R9253 |
T14168 |
T14156 |
punct |
),Vector |
R9254 |
T14169 |
T14139 |
amod |
secondary,antibodies |
R9255 |
T14170 |
T14139 |
nmod |
goat,antibodies |
R9256 |
T14171 |
T14139 |
amod |
anti-rabbit,antibodies |
R9257 |
T14172 |
T14053 |
punct |
.,used |
R9258 |
T14174 |
T14175 |
det |
The,epithelium |
R9259 |
T14175 |
T14178 |
nsubjpass |
epithelium,obtained |
R9260 |
T14176 |
T14175 |
amod |
main,epithelium |
R9261 |
T14177 |
T14175 |
amod |
olfactory,epithelium |
R9262 |
T14179 |
T14178 |
auxpass |
was,obtained |
R9263 |
T14180 |
T14178 |
prep |
via,obtained |
R9264 |
T14181 |
T14182 |
compound |
cryostat,sectioning |
R9265 |
T14182 |
T14180 |
pobj |
sectioning,via |
R9266 |
T14183 |
T14178 |
punct |
", ",obtained |
R9267 |
T14184 |
T14178 |
cc |
and,obtained |
R9268 |
T14185 |
T14186 |
nsubjpass |
immunohistochemistry,performed |
R9269 |
T14186 |
T14178 |
conj |
performed,obtained |
R9270 |
T14187 |
T14186 |
auxpass |
was,performed |
R9271 |
T14188 |
T14189 |
punct |
(,BAbCO |
R9272 |
T14189 |
T14186 |
parataxis |
BAbCO,performed |
R9273 |
T14190 |
T14191 |
amod |
primary,Cre |
R9274 |
T14191 |
T14193 |
dep |
Cre,1 |
R9275 |
T14192 |
T14191 |
compound |
antibody,Cre |
R9276 |
T14193 |
T14189 |
dep |
1,BAbCO |
R9277 |
T14194 |
T14193 |
punct |
", ",1 |
R9278 |
T14195 |
T14196 |
punct |
:,"5,000" |
R9279 |
T14196 |
T14193 |
prep |
"5,000",1 |
R9280 |
T14197 |
T14193 |
punct |
", ",1 |
R9281 |
T14198 |
T14193 |
amod |
polyclonal,1 |
R9282 |
T14199 |
T14189 |
punct |
;,BAbCO |
R9283 |
T14200 |
T14189 |
punct |
),BAbCO |
R9284 |
T14201 |
T14186 |
punct |
.,performed |
R9285 |
T14203 |
T14204 |
compound |
X,gal |
R9286 |
T14204 |
T14206 |
compound |
gal,staining |
R9287 |
T14205 |
T14204 |
punct |
-,gal |
R9288 |
T14206 |
T14207 |
nsubjpass |
staining,performed |
R9289 |
T14208 |
T14207 |
auxpass |
was,performed |
R9290 |
T14209 |
T14210 |
mark |
as,described |
R9291 |
T14210 |
T14207 |
advcl |
described,performed |
R9292 |
T14211 |
T14212 |
punct |
[,89 |
R9293 |
T14212 |
T14207 |
parataxis |
89,performed |
R9294 |
T14213 |
T14212 |
punct |
],89 |
R9295 |
T14214 |
T14207 |
punct |
.,performed |
R9296 |
T14252 |
T14253 |
compound |
Immunoblot,analysis |
R9297 |
T14255 |
T14256 |
compound |
Mouse,brains |
R9298 |
T14256 |
T14257 |
nsubjpass |
brains,removed |
R9299 |
T14258 |
T14257 |
auxpass |
were,removed |
R9300 |
T14259 |
T14257 |
punct |
", ",removed |
R9301 |
T14260 |
T14257 |
cc |
and,removed |
R9302 |
T14261 |
T14262 |
det |
the,hippocampus |
R9303 |
T14262 |
T14263 |
nsubjpass |
hippocampus,isolated |
R9304 |
T14263 |
T14257 |
conj |
isolated,removed |
R9305 |
T14264 |
T14262 |
punct |
", ",hippocampus |
R9306 |
T14265 |
T14266 |
amod |
olfactory,bulb |
R9307 |
T14266 |
T14262 |
conj |
bulb,hippocampus |
R9308 |
T14267 |
T14266 |
punct |
", ",bulb |
R9309 |
T14268 |
T14266 |
cc |
and,bulb |
R9310 |
T14269 |
T14270 |
amod |
remaining,areas |
R9311 |
T14270 |
T14266 |
conj |
areas,bulb |
R9312 |
T14271 |
T14270 |
compound |
forebrain,areas |
R9313 |
T14272 |
T14263 |
auxpass |
were,isolated |
R9314 |
T14273 |
T14263 |
punct |
.,isolated |
R9315 |
T14275 |
T14276 |
amod |
Total,protein |
R9316 |
T14276 |
T14277 |
nsubjpass |
protein,prepared |
R9317 |
T14278 |
T14277 |
auxpass |
was,prepared |
R9318 |
T14279 |
T14277 |
punct |
", ",prepared |
R9319 |
T14280 |
T14277 |
cc |
and,prepared |
R9320 |
T14281 |
T14282 |
nsubjpass |
immunoblots,performed |
R9321 |
T14282 |
T14277 |
conj |
performed,prepared |
R9322 |
T14283 |
T14282 |
auxpass |
were,performed |
R9323 |
T14284 |
T14285 |
mark |
as,described |
R9324 |
T14285 |
T14282 |
advcl |
described,performed |
R9325 |
T14286 |
T14287 |
punct |
[,87 |
R9326 |
T14287 |
T14282 |
parataxis |
87,performed |
R9327 |
T14288 |
T14287 |
punct |
],87 |
R9328 |
T14289 |
T14282 |
punct |
.,performed |
R9329 |
T14291 |
T14292 |
nsubj |
Antibodies,were |
R9330 |
T14293 |
T14291 |
acl |
used,Antibodies |
R9331 |
T14294 |
T14292 |
prep |
against,were |
R9332 |
T14295 |
T14296 |
compound |
GluR,B |
R9333 |
T14296 |
T14294 |
pobj |
B,against |
R9334 |
T14297 |
T14296 |
punct |
-,B |
R9335 |
T14298 |
T14299 |
punct |
(,Chemicon |
R9336 |
T14299 |
T14296 |
parataxis |
Chemicon,B |
R9337 |
T14300 |
T14301 |
dep |
1,monoclonal |
R9338 |
T14301 |
T14299 |
dep |
monoclonal,Chemicon |
R9339 |
T14302 |
T14303 |
punct |
:,800 |
R9340 |
T14303 |
T14300 |
prep |
800,1 |
R9341 |
T14304 |
T14301 |
punct |
", ",monoclonal |
R9342 |
T14305 |
T14299 |
punct |
;,Chemicon |
R9343 |
T14306 |
T14299 |
punct |
),Chemicon |
R9344 |
T14307 |
T14296 |
punct |
", ",B |
R9345 |
T14308 |
T14309 |
compound |
β,actin |
R9346 |
T14309 |
T14296 |
appos |
actin,B |
R9347 |
T14310 |
T14309 |
punct |
-,actin |
R9348 |
T14311 |
T14312 |
punct |
(,Sigma |
R9349 |
T14312 |
T14309 |
parataxis |
Sigma,actin |
R9350 |
T14313 |
T14314 |
dep |
1,monoclonal |
R9351 |
T14314 |
T14312 |
dep |
monoclonal,Sigma |
R9352 |
T14315 |
T14316 |
punct |
:,"40,000" |
R9353 |
T14316 |
T14313 |
prep |
"40,000",1 |
R9354 |
T14317 |
T14314 |
punct |
", ",monoclonal |
R9355 |
T14318 |
T14312 |
punct |
;,Sigma |
R9356 |
T14319 |
T14312 |
punct |
", ",Sigma |
R9357 |
T14320 |
T14321 |
compound |
St.,Louis |
R9358 |
T14321 |
T14312 |
npadvmod |
Louis,Sigma |
R9359 |
T14322 |
T14312 |
punct |
", ",Sigma |
R9360 |
T14323 |
T14312 |
npadvmod |
Missouri,Sigma |
R9361 |
T14324 |
T14312 |
punct |
", ",Sigma |
R9362 |
T14325 |
T14326 |
compound |
United,States |
R9363 |
T14326 |
T14312 |
npadvmod |
States,Sigma |
R9364 |
T14327 |
T14312 |
punct |
),Sigma |
R9365 |
T14328 |
T14296 |
prep |
as,B |
R9366 |
T14329 |
T14330 |
det |
an,standard |
R9367 |
T14330 |
T14328 |
pobj |
standard,as |
R9368 |
T14331 |
T14330 |
amod |
internal,standard |
R9369 |
T14332 |
T14296 |
punct |
", ",B |
R9370 |
T14333 |
T14296 |
cc |
and,B |
R9371 |
T14334 |
T14335 |
amod |
secondary,antibodies |
R9372 |
T14335 |
T14296 |
conj |
antibodies,B |
R9373 |
T14336 |
T14335 |
nmod |
goat,antibodies |
R9374 |
T14337 |
T14336 |
amod |
anti-rabbit,goat |
R9375 |
T14338 |
T14336 |
cc |
and,goat |
R9376 |
T14339 |
T14336 |
conj |
goat,goat |
R9377 |
T14340 |
T14339 |
amod |
anti-mouse,goat |
R9378 |
T14341 |
T14342 |
punct |
(,1 |
R9379 |
T14342 |
T14335 |
parataxis |
1,antibodies |
R9380 |
T14343 |
T14342 |
dep |
Vector,1 |
R9381 |
T14344 |
T14342 |
punct |
", ",1 |
R9382 |
T14345 |
T14346 |
punct |
:,"15,000" |
R9383 |
T14346 |
T14342 |
prep |
"15,000",1 |
R9384 |
T14347 |
T14342 |
punct |
),1 |
R9385 |
T14348 |
T14292 |
punct |
.,were |
R9386 |
T14350 |
T14351 |
nsubjpass |
Immunoreactivity,detected |
R9387 |
T14352 |
T14351 |
auxpass |
was,detected |
R9388 |
T14353 |
T14351 |
prep |
with,detected |
R9389 |
T14354 |
T14353 |
pobj |
ECLplus,with |
R9390 |
T14355 |
T14356 |
punct |
(,Amersham |
R9391 |
T14356 |
T14354 |
parataxis |
Amersham,ECLplus |
R9392 |
T14357 |
T14356 |
punct |
", ",Amersham |
R9393 |
T14358 |
T14359 |
compound |
Little,Chalfont |
R9394 |
T14359 |
T14356 |
npadvmod |
Chalfont,Amersham |
R9395 |
T14360 |
T14356 |
punct |
", ",Amersham |
R9396 |
T14361 |
T14362 |
compound |
United,Kingdom |
R9397 |
T14362 |
T14356 |
npadvmod |
Kingdom,Amersham |
R9398 |
T14363 |
T14356 |
punct |
),Amersham |
R9399 |
T14364 |
T14351 |
punct |
", ",detected |
R9400 |
T14365 |
T14351 |
cc |
and,detected |
R9401 |
T14366 |
T14367 |
nsubj |
immunoblots,scanned |
R9402 |
T14367 |
T14351 |
conj |
scanned,detected |
R9403 |
T14368 |
T14367 |
aux |
were,scanned |
R9404 |
T14369 |
T14367 |
cc |
and,scanned |
R9405 |
T14370 |
T14371 |
advmod |
quantitatively,analyzed |
R9406 |
T14371 |
T14367 |
conj |
analyzed,scanned |
R9407 |
T14372 |
T14367 |
prep |
with,scanned |
R9408 |
T14373 |
T14372 |
pobj |
ImageJ,with |
R9409 |
T14374 |
T14367 |
punct |
.,scanned |
R9410 |
T14415 |
T14416 |
amod |
Behavioral,analysis |
R9411 |
T14416 |
T14417 |
dep |
analysis,Subjects |
R9412 |
T14418 |
T14417 |
punct |
: ,Subjects |
R9413 |
T14420 |
T14421 |
det |
All,mice |
R9414 |
T14421 |
T14422 |
nsubj |
mice,were |
R9415 |
T14423 |
T14424 |
quantmod |
four,six |
R9416 |
T14424 |
T14426 |
nummod |
six,weeks |
R9417 |
T14425 |
T14424 |
quantmod |
to,six |
R9418 |
T14426 |
T14427 |
npadvmod |
weeks,old |
R9419 |
T14427 |
T14422 |
acomp |
old,were |
R9420 |
T14428 |
T14422 |
prep |
at,were |
R9421 |
T14429 |
T14430 |
det |
the,beginning |
R9422 |
T14430 |
T14428 |
pobj |
beginning,at |
R9423 |
T14431 |
T14430 |
prep |
of,beginning |
R9424 |
T14432 |
T14433 |
det |
the,experiments |
R9425 |
T14433 |
T14431 |
pobj |
experiments,of |
R9426 |
T14434 |
T14422 |
punct |
.,were |
R9427 |
T14436 |
T14437 |
nsubjpass |
Subjects,maintained |
R9428 |
T14438 |
T14437 |
auxpass |
were,maintained |
R9429 |
T14439 |
T14437 |
prep |
on,maintained |
R9430 |
T14440 |
T14441 |
det |
a,cycle |
R9431 |
T14441 |
T14439 |
pobj |
cycle,on |
R9432 |
T14442 |
T14443 |
nummod |
12,h |
R9433 |
T14443 |
T14441 |
compound |
h,cycle |
R9434 |
T14444 |
T14443 |
punct |
-,h |
R9435 |
T14445 |
T14446 |
compound |
light,dark |
R9436 |
T14446 |
T14441 |
compound |
dark,cycle |
R9437 |
T14447 |
T14446 |
punct |
-,dark |
R9438 |
T14448 |
T14437 |
prep |
in,maintained |
R9439 |
T14449 |
T14450 |
amod |
isolated,cages |
R9440 |
T14450 |
T14448 |
pobj |
cages,in |
R9441 |
T14451 |
T14437 |
prep |
in,maintained |
R9442 |
T14452 |
T14453 |
det |
a,facility |
R9443 |
T14453 |
T14451 |
pobj |
facility,in |
R9444 |
T14454 |
T14455 |
npadvmod |
temperature,controlled |
R9445 |
T14455 |
T14453 |
amod |
controlled,facility |
R9446 |
T14456 |
T14454 |
cc |
and,temperature |
R9447 |
T14457 |
T14454 |
conj |
humidity,temperature |
R9448 |
T14458 |
T14455 |
punct |
-,controlled |
R9449 |
T14459 |
T14453 |
compound |
animal,facility |
R9450 |
T14460 |
T14437 |
punct |
.,maintained |
R9451 |
T14462 |
T14463 |
det |
All,training |
R9452 |
T14463 |
T14465 |
nsubjpass |
training,conducted |
R9453 |
T14464 |
T14463 |
amod |
behavioral,training |
R9454 |
T14466 |
T14465 |
auxpass |
was,conducted |
R9455 |
T14467 |
T14465 |
prep |
during,conducted |
R9456 |
T14468 |
T14467 |
pobj |
daytime,during |
R9457 |
T14469 |
T14465 |
punct |
.,conducted |
R9458 |
T14471 |
T14472 |
prep |
During,kept |
R9459 |
T14473 |
T14474 |
det |
the,period |
R9460 |
T14474 |
T14471 |
pobj |
period,During |
R9461 |
T14475 |
T14474 |
compound |
training,period |
R9462 |
T14476 |
T14472 |
punct |
", ",kept |
R9463 |
T14477 |
T14472 |
nsubjpass |
animals,kept |
R9464 |
T14478 |
T14472 |
auxpass |
were,kept |
R9465 |
T14479 |
T14472 |
prep |
on,kept |
R9466 |
T14480 |
T14481 |
amod |
free,food |
R9467 |
T14481 |
T14479 |
pobj |
food,on |
R9468 |
T14482 |
T14479 |
cc |
but,on |
R9469 |
T14483 |
T14479 |
conj |
on,on |
R9470 |
T14484 |
T14485 |
det |
a,schedule |
R9471 |
T14485 |
T14483 |
pobj |
schedule,on |
R9472 |
T14486 |
T14487 |
compound |
water,restriction |
R9473 |
T14487 |
T14485 |
compound |
restriction,schedule |
R9474 |
T14488 |
T14487 |
punct |
-,restriction |
R9475 |
T14489 |
T14485 |
acl |
designed,schedule |
R9476 |
T14490 |
T14491 |
aux |
to,keep |
R9477 |
T14491 |
T14489 |
advcl |
keep,designed |
R9478 |
T14492 |
T14491 |
dobj |
them,keep |
R9479 |
T14493 |
T14491 |
oprd |
at,keep |
R9480 |
T14494 |
T14495 |
punct |
>,85 |
R9481 |
T14495 |
T14496 |
nummod |
85,% |
R9482 |
T14496 |
T14493 |
pobj |
%,at |
R9483 |
T14497 |
T14496 |
prep |
of,% |
R9484 |
T14498 |
T14499 |
poss |
their,weight |
R9485 |
T14499 |
T14497 |
pobj |
weight,of |
R9486 |
T14500 |
T14501 |
amod |
free,food |
R9487 |
T14501 |
T14499 |
compound |
food,weight |
R9488 |
T14502 |
T14499 |
compound |
body,weight |
R9489 |
T14503 |
T14472 |
punct |
.,kept |
R9490 |
T14505 |
T14506 |
amod |
Continuous,restriction |
R9491 |
T14506 |
T14508 |
nsubj |
restriction,was |
R9492 |
T14507 |
T14506 |
compound |
water,restriction |
R9493 |
T14509 |
T14508 |
neg |
never,was |
R9494 |
T14510 |
T14508 |
advmod |
longer,was |
R9495 |
T14511 |
T14510 |
prep |
than,longer |
R9496 |
T14512 |
T14513 |
nummod |
12,h |
R9497 |
T14513 |
T14511 |
pobj |
h,than |
R9498 |
T14514 |
T14508 |
punct |
.,was |
R9499 |
T14516 |
T14517 |
det |
All,care |
R9500 |
T14517 |
T14519 |
nsubj |
care,were |
R9501 |
T14518 |
T14517 |
compound |
animal,care |
R9502 |
T14520 |
T14517 |
cc |
and,care |
R9503 |
T14521 |
T14517 |
conj |
procedures,care |
R9504 |
T14522 |
T14519 |
prep |
in,were |
R9505 |
T14523 |
T14522 |
pobj |
accordance,in |
R9506 |
T14524 |
T14523 |
prep |
with,accordance |
R9507 |
T14525 |
T14526 |
det |
the,guidelines |
R9508 |
T14526 |
T14524 |
pobj |
guidelines,with |
R9509 |
T14527 |
T14526 |
compound |
animal,guidelines |
R9510 |
T14528 |
T14526 |
compound |
ethics,guidelines |
R9511 |
T14529 |
T14526 |
prep |
of,guidelines |
R9512 |
T14530 |
T14531 |
det |
the,Society |
R9513 |
T14531 |
T14529 |
pobj |
Society,of |
R9514 |
T14532 |
T14533 |
compound |
Max,Planck |
R9515 |
T14533 |
T14531 |
compound |
Planck,Society |
R9516 |
T14534 |
T14533 |
punct |
-,Planck |
R9517 |
T14535 |
T14519 |
punct |
.,were |
R9518 |
T14574 |
T14575 |
det |
All,experiments |
R9519 |
T14575 |
T14578 |
nsubjpass |
experiments,performed |
R9520 |
T14576 |
T14577 |
amod |
olfactory,discrimination |
R9521 |
T14577 |
T14575 |
compound |
discrimination,experiments |
R9522 |
T14579 |
T14578 |
auxpass |
were,performed |
R9523 |
T14580 |
T14578 |
advcl |
using,performed |
R9524 |
T14581 |
T14582 |
nummod |
three,olfactometers |
R9525 |
T14582 |
T14580 |
dobj |
olfactometers,using |
R9526 |
T14583 |
T14582 |
amod |
modified,olfactometers |
R9527 |
T14584 |
T14585 |
nummod |
eight,channel |
R9528 |
T14585 |
T14582 |
compound |
channel,olfactometers |
R9529 |
T14586 |
T14585 |
punct |
-,channel |
R9530 |
T14587 |
T14588 |
punct |
(,Knosys |
R9531 |
T14588 |
T14582 |
parataxis |
Knosys,olfactometers |
R9532 |
T14589 |
T14588 |
punct |
[,Knosys |
R9533 |
T14590 |
T14588 |
dep |
61,Knosys |
R9534 |
T14591 |
T14588 |
punct |
],Knosys |
R9535 |
T14592 |
T14588 |
punct |
", ",Knosys |
R9536 |
T14593 |
T14588 |
punct |
", ",Knosys |
R9537 |
T14594 |
T14588 |
npadvmod |
Bethesda,Knosys |
R9538 |
T14595 |
T14588 |
punct |
", ",Knosys |
R9539 |
T14596 |
T14588 |
npadvmod |
Maryland,Knosys |
R9540 |
T14597 |
T14588 |
punct |
", ",Knosys |
R9541 |
T14598 |
T14599 |
compound |
United,States |
R9542 |
T14599 |
T14588 |
npadvmod |
States,Knosys |
R9543 |
T14600 |
T14599 |
prep |
of,States |
R9544 |
T14601 |
T14600 |
pobj |
America,of |
R9545 |
T14602 |
T14588 |
punct |
),Knosys |
R9546 |
T14603 |
T14582 |
acl |
operated,olfactometers |
R9547 |
T14604 |
T14603 |
prep |
by,operated |
R9548 |
T14605 |
T14606 |
amod |
custom,written |
R9549 |
T14606 |
T14608 |
amod |
written,software |
R9550 |
T14607 |
T14606 |
punct |
-,written |
R9551 |
T14608 |
T14604 |
pobj |
software,by |
R9552 |
T14609 |
T14608 |
prep |
in,software |
R9553 |
T14610 |
T14609 |
pobj |
Igor,in |
R9554 |
T14611 |
T14612 |
punct |
(,Metrics |
R9555 |
T14612 |
T14610 |
parataxis |
Metrics,Igor |
R9556 |
T14613 |
T14612 |
compound |
Wave,Metrics |
R9557 |
T14614 |
T14612 |
punct |
", ",Metrics |
R9558 |
T14615 |
T14616 |
compound |
Lake,Oswego |
R9559 |
T14616 |
T14612 |
npadvmod |
Oswego,Metrics |
R9560 |
T14617 |
T14612 |
punct |
", ",Metrics |
R9561 |
T14618 |
T14612 |
npadvmod |
Oregon,Metrics |
R9562 |
T14619 |
T14612 |
punct |
", ",Metrics |
R9563 |
T14620 |
T14621 |
compound |
United,States |
R9564 |
T14621 |
T14612 |
npadvmod |
States,Metrics |
R9565 |
T14622 |
T14621 |
prep |
of,States |
R9566 |
T14623 |
T14622 |
pobj |
America,of |
R9567 |
T14624 |
T14612 |
punct |
),Metrics |
R9568 |
T14625 |
T14603 |
prep |
on,operated |
R9569 |
T14626 |
T14627 |
nmod |
Pentium,I |
R9570 |
T14627 |
T14628 |
nummod |
I,PCs |
R9571 |
T14628 |
T14625 |
pobj |
PCs,on |
R9572 |
T14629 |
T14627 |
punct |
", ",I |
R9573 |
T14630 |
T14627 |
conj |
II,I |
R9574 |
T14631 |
T14630 |
punct |
", ",II |
R9575 |
T14632 |
T14630 |
cc |
and,II |
R9576 |
T14633 |
T14630 |
conj |
III,II |
R9577 |
T14634 |
T14628 |
acl |
running,PCs |
R9578 |
T14635 |
T14636 |
compound |
Microsoft,Windows |
R9579 |
T14636 |
T14634 |
dobj |
Windows,running |
R9580 |
T14637 |
T14636 |
nummod |
98,Windows |
R9581 |
T14638 |
T14578 |
punct |
.,performed |
R9582 |
T14640 |
T14641 |
amod |
Great,care |
R9583 |
T14641 |
T14642 |
nsubjpass |
care,taken |
R9584 |
T14643 |
T14642 |
auxpass |
was,taken |
R9585 |
T14644 |
T14645 |
aux |
to,counterbalance |
R9586 |
T14645 |
T14642 |
xcomp |
counterbalance,taken |
R9587 |
T14646 |
T14645 |
dobj |
groups,counterbalance |
R9588 |
T14647 |
T14645 |
prep |
between,counterbalance |
R9589 |
T14648 |
T14647 |
pobj |
setups,between |
R9590 |
T14649 |
T14642 |
punct |
.,taken |
R9591 |
T14651 |
T14652 |
prep |
In,presented |
R9592 |
T14653 |
T14651 |
pobj |
brief,In |
R9593 |
T14654 |
T14652 |
punct |
", ",presented |
R9594 |
T14655 |
T14652 |
nsubjpass |
animals,presented |
R9595 |
T14656 |
T14652 |
auxpass |
were,presented |
R9596 |
T14657 |
T14652 |
prep |
with,presented |
R9597 |
T14658 |
T14657 |
pobj |
odor,with |
R9598 |
T14659 |
T14658 |
prep |
from,odor |
R9599 |
T14660 |
T14661 |
quantmod |
one,eight |
R9600 |
T14661 |
T14664 |
nummod |
eight,channels |
R9601 |
T14662 |
T14661 |
quantmod |
out,eight |
R9602 |
T14663 |
T14661 |
quantmod |
of,eight |
R9603 |
T14664 |
T14659 |
pobj |
channels,from |
R9604 |
T14665 |
T14664 |
amod |
possible,channels |
R9605 |
T14666 |
T14664 |
compound |
odor,channels |
R9606 |
T14667 |
T14652 |
cc |
and,presented |
R9607 |
T14668 |
T14652 |
conj |
rewarded,presented |
R9608 |
T14669 |
T14668 |
prep |
with,rewarded |
R9609 |
T14670 |
T14671 |
det |
a,drop |
R9610 |
T14671 |
T14669 |
pobj |
drop,with |
R9611 |
T14672 |
T14673 |
quantmod |
2,4 |
R9612 |
T14673 |
T14676 |
nummod |
4,μl |
R9613 |
T14674 |
T14673 |
punct |
-,4 |
R9614 |
T14675 |
T14673 |
quantmod |
to,4 |
R9615 |
T14676 |
T14671 |
compound |
μl,drop |
R9616 |
T14677 |
T14676 |
punct |
-,μl |
R9617 |
T14678 |
T14671 |
prep |
of,drop |
R9618 |
T14679 |
T14678 |
pobj |
water,of |
R9619 |
T14680 |
T14671 |
prep |
in,drop |
R9620 |
T14681 |
T14682 |
det |
a,port |
R9621 |
T14682 |
T14680 |
pobj |
port,in |
R9622 |
T14683 |
T14682 |
amod |
combined,port |
R9623 |
T14684 |
T14685 |
compound |
odor,reward |
R9624 |
T14685 |
T14682 |
compound |
reward,port |
R9625 |
T14686 |
T14685 |
punct |
/,reward |
R9626 |
T14687 |
T14688 |
punct |
(,1B |
R9627 |
T14688 |
T14668 |
parataxis |
1B,rewarded |
R9628 |
T14689 |
T14688 |
compound |
Figure,1B |
R9629 |
T14690 |
T14688 |
punct |
),1B |
R9630 |
T14691 |
T14668 |
punct |
", ",rewarded |
R9631 |
T14692 |
T14668 |
advcl |
ensuring,rewarded |
R9632 |
T14693 |
T14694 |
amod |
tight,association |
R9633 |
T14694 |
T14692 |
dobj |
association,ensuring |
R9634 |
T14695 |
T14694 |
prep |
of,association |
R9635 |
T14696 |
T14697 |
det |
the,reward |
R9636 |
T14697 |
T14695 |
pobj |
reward,of |
R9637 |
T14698 |
T14697 |
compound |
water,reward |
R9638 |
T14699 |
T14697 |
punct |
-,reward |
R9639 |
T14700 |
T14694 |
prep |
with,association |
R9640 |
T14701 |
T14702 |
det |
a,odorant |
R9641 |
T14702 |
T14700 |
pobj |
odorant,with |
R9642 |
T14703 |
T14702 |
amod |
presented,odorant |
R9643 |
T14704 |
T14652 |
punct |
.,presented |
R9644 |
T14706 |
T14707 |
compound |
Head,insertion |
R9645 |
T14707 |
T14708 |
nsubjpass |
insertion,monitored |
R9646 |
T14709 |
T14707 |
prep |
into,insertion |
R9647 |
T14710 |
T14711 |
det |
the,port |
R9648 |
T14711 |
T14709 |
pobj |
port,into |
R9649 |
T14712 |
T14708 |
auxpass |
was,monitored |
R9650 |
T14713 |
T14708 |
prep |
by,monitored |
R9651 |
T14714 |
T14715 |
det |
an,beam |
R9652 |
T14715 |
T14713 |
pobj |
beam,by |
R9653 |
T14716 |
T14715 |
compound |
IR,beam |
R9654 |
T14717 |
T14715 |
cc |
and,beam |
R9655 |
T14718 |
T14715 |
conj |
photodiode,beam |
R9656 |
T14719 |
T14720 |
punct |
(,1B |
R9657 |
T14720 |
T14708 |
parataxis |
1B,monitored |
R9658 |
T14721 |
T14720 |
compound |
Figure,1B |
R9659 |
T14722 |
T14720 |
punct |
),1B |
R9660 |
T14723 |
T14708 |
punct |
.,monitored |
R9661 |
T14725 |
T14726 |
nsubj |
Odors,were |
R9662 |
T14727 |
T14725 |
acl |
used,Odors |
R9663 |
T14728 |
T14729 |
compound |
n,amyl |
R9664 |
T14729 |
T14731 |
compound |
amyl,acetate |
R9665 |
T14730 |
T14729 |
punct |
-,amyl |
R9666 |
T14731 |
T14726 |
attr |
acetate,were |
R9667 |
T14732 |
T14731 |
punct |
", ",acetate |
R9668 |
T14733 |
T14734 |
compound |
ethyl,butyrate |
R9669 |
T14734 |
T14731 |
conj |
butyrate,acetate |
R9670 |
T14735 |
T14734 |
punct |
", ",butyrate |
R9671 |
T14736 |
T14737 |
amod |
pelargonic,acid |
R9672 |
T14737 |
T14734 |
conj |
acid,butyrate |
R9673 |
T14738 |
T14737 |
punct |
", ",acid |
R9674 |
T14739 |
T14740 |
amod |
valeric,acid |
R9675 |
T14740 |
T14737 |
conj |
acid,acid |
R9676 |
T14741 |
T14740 |
punct |
", ",acid |
R9677 |
T14742 |
T14740 |
cc |
and,acid |
R9678 |
T14743 |
T14744 |
amod |
binary,mixtures |
R9679 |
T14744 |
T14740 |
conj |
mixtures,acid |
R9680 |
T14745 |
T14744 |
prep |
of,mixtures |
R9681 |
T14746 |
T14745 |
pobj |
cineol,of |
R9682 |
T14747 |
T14746 |
cc |
and,cineol |
R9683 |
T14748 |
T14746 |
conj |
eugenol,cineol |
R9684 |
T14749 |
T14726 |
punct |
.,were |
R9685 |
T14751 |
T14752 |
mark |
If,noted |
R9686 |
T14752 |
T14755 |
advcl |
noted,diluted |
R9687 |
T14753 |
T14752 |
neg |
not,noted |
R9688 |
T14754 |
T14752 |
advmod |
otherwise,noted |
R9689 |
T14756 |
T14755 |
punct |
", ",diluted |
R9690 |
T14757 |
T14755 |
nsubjpass |
odors,diluted |
R9691 |
T14758 |
T14755 |
auxpass |
were,diluted |
R9692 |
T14759 |
T14755 |
prep |
to,diluted |
R9693 |
T14760 |
T14761 |
nummod |
1,% |
R9694 |
T14761 |
T14759 |
pobj |
%,to |
R9695 |
T14762 |
T14755 |
prep |
in,diluted |
R9696 |
T14763 |
T14764 |
compound |
mineral,oil |
R9697 |
T14764 |
T14762 |
pobj |
oil,in |
R9698 |
T14765 |
T14766 |
punct |
(,Chemie |
R9699 |
T14766 |
T14755 |
parataxis |
Chemie,diluted |
R9700 |
T14767 |
T14766 |
compound |
Fluka,Chemie |
R9701 |
T14768 |
T14766 |
punct |
", ",Chemie |
R9702 |
T14769 |
T14766 |
npadvmod |
Steinheim,Chemie |
R9703 |
T14770 |
T14766 |
punct |
", ",Chemie |
R9704 |
T14771 |
T14766 |
npadvmod |
Germany,Chemie |
R9705 |
T14772 |
T14766 |
punct |
),Chemie |
R9706 |
T14773 |
T14755 |
cc |
and,diluted |
R9707 |
T14774 |
T14775 |
advmod |
further,diluted |
R9708 |
T14775 |
T14755 |
conj |
diluted,diluted |
R9709 |
T14776 |
T14775 |
prep |
by,diluted |
R9710 |
T14777 |
T14776 |
pobj |
airflow,by |
R9711 |
T14778 |
T14775 |
prep |
to,diluted |
R9712 |
T14779 |
T14780 |
det |
a,concentration |
R9713 |
T14780 |
T14778 |
pobj |
concentration,to |
R9714 |
T14781 |
T14780 |
amod |
final,concentration |
R9715 |
T14782 |
T14780 |
prep |
of,concentration |
R9716 |
T14783 |
T14784 |
advmod |
approximately,0.15 |
R9717 |
T14784 |
T14785 |
nummod |
0.15,% |
R9718 |
T14785 |
T14782 |
pobj |
%,of |
R9719 |
T14786 |
T14755 |
punct |
.,diluted |
R9720 |
T14788 |
T14789 |
det |
All,dilutions |
R9721 |
T14789 |
T14790 |
nsubj |
dilutions,refer |
R9722 |
T14791 |
T14789 |
prep |
in,dilutions |
R9723 |
T14792 |
T14793 |
det |
the,text |
R9724 |
T14793 |
T14791 |
pobj |
text,in |
R9725 |
T14794 |
T14790 |
prep |
to,refer |
R9726 |
T14795 |
T14796 |
det |
the,dilution |
R9727 |
T14796 |
T14794 |
pobj |
dilution,to |
R9728 |
T14797 |
T14796 |
prep |
in,dilution |
R9729 |
T14798 |
T14799 |
compound |
mineral,oil |
R9730 |
T14799 |
T14797 |
pobj |
oil,in |
R9731 |
T14800 |
T14790 |
punct |
.,refer |
R9732 |
T14802 |
T14803 |
det |
All,chemicals |
R9733 |
T14803 |
T14804 |
nsubjpass |
chemicals,obtained |
R9734 |
T14805 |
T14804 |
auxpass |
were,obtained |
R9735 |
T14806 |
T14804 |
prep |
from,obtained |
R9736 |
T14807 |
T14808 |
compound |
Fluka,Chemie |
R9737 |
T14808 |
T14806 |
pobj |
Chemie,from |
R9738 |
T14809 |
T14804 |
punct |
.,obtained |
R9739 |
T14842 |
T14843 |
compound |
Task,habituation |
R9740 |
T14843 |
T14844 |
compound |
habituation,training |
R9741 |
T14846 |
T14847 |
advcl |
Beginning,trained |
R9742 |
T14848 |
T14849 |
quantmod |
1,3 |
R9743 |
T14849 |
T14851 |
nummod |
3,d |
R9744 |
T14850 |
T14849 |
punct |
–,3 |
R9745 |
T14851 |
T14852 |
npadvmod |
d,after |
R9746 |
T14852 |
T14846 |
prep |
after,Beginning |
R9747 |
T14853 |
T14854 |
det |
the,start |
R9748 |
T14854 |
T14852 |
pobj |
start,after |
R9749 |
T14855 |
T14854 |
prep |
of,start |
R9750 |
T14856 |
T14857 |
det |
the,schedule |
R9751 |
T14857 |
T14855 |
pobj |
schedule,of |
R9752 |
T14858 |
T14859 |
compound |
water,restriction |
R9753 |
T14859 |
T14857 |
compound |
restriction,schedule |
R9754 |
T14860 |
T14847 |
punct |
", ",trained |
R9755 |
T14861 |
T14847 |
nsubjpass |
animals,trained |
R9756 |
T14862 |
T14847 |
auxpass |
were,trained |
R9757 |
T14863 |
T14847 |
advcl |
using,trained |
R9758 |
T14864 |
T14865 |
amod |
standard,procedures |
R9759 |
T14865 |
T14863 |
dobj |
procedures,using |
R9760 |
T14866 |
T14865 |
nmod |
operant,procedures |
R9761 |
T14867 |
T14866 |
punct |
-,operant |
R9762 |
T14868 |
T14866 |
amod |
conditioning,operant |
R9763 |
T14869 |
T14870 |
punct |
[,3 |
R9764 |
T14870 |
T14847 |
parataxis |
3,trained |
R9765 |
T14871 |
T14870 |
punct |
],3 |
R9766 |
T14872 |
T14847 |
punct |
.,trained |
R9767 |
T14874 |
T14875 |
prep |
In,rewarded |
R9768 |
T14876 |
T14877 |
det |
a,step |
R9769 |
T14877 |
T14874 |
pobj |
step,In |
R9770 |
T14878 |
T14877 |
amod |
first,step |
R9771 |
T14879 |
T14877 |
compound |
pretraining,step |
R9772 |
T14880 |
T14875 |
punct |
", ",rewarded |
R9773 |
T14881 |
T14882 |
det |
each,lick |
R9774 |
T14882 |
T14875 |
nsubjpass |
lick,rewarded |
R9775 |
T14883 |
T14882 |
prep |
at,lick |
R9776 |
T14884 |
T14885 |
det |
the,tube |
R9777 |
T14885 |
T14883 |
pobj |
tube,at |
R9778 |
T14886 |
T14885 |
compound |
water,tube |
R9779 |
T14887 |
T14885 |
compound |
delivery,tube |
R9780 |
T14888 |
T14875 |
auxpass |
was,rewarded |
R9781 |
T14889 |
T14875 |
punct |
.,rewarded |
R9782 |
T14891 |
T14892 |
prep |
After,entered |
R9783 |
T14893 |
T14894 |
nummod |
20,licks |
R9784 |
T14894 |
T14891 |
pobj |
licks,After |
R9785 |
T14895 |
T14892 |
punct |
", ",entered |
R9786 |
T14896 |
T14897 |
det |
a,stage |
R9787 |
T14897 |
T14892 |
nsubjpass |
stage,entered |
R9788 |
T14898 |
T14897 |
amod |
second,stage |
R9789 |
T14899 |
T14892 |
auxpass |
was,entered |
R9790 |
T14900 |
T14901 |
prep |
in,initiated |
R9791 |
T14901 |
T14892 |
ccomp |
initiated,entered |
R9792 |
T14902 |
T14900 |
pobj |
which,in |
R9793 |
T14903 |
T14904 |
compound |
head,insertion |
R9794 |
T14904 |
T14901 |
nsubj |
insertion,initiated |
R9795 |
T14905 |
T14906 |
det |
a,presentation |
R9796 |
T14906 |
T14901 |
dobj |
presentation,initiated |
R9797 |
T14907 |
T14908 |
nummod |
2,s |
R9798 |
T14908 |
T14906 |
nmod |
s,presentation |
R9799 |
T14909 |
T14908 |
punct |
-,s |
R9800 |
T14910 |
T14906 |
punct |
“,presentation |
R9801 |
T14911 |
T14906 |
nmod |
odor,presentation |
R9802 |
T14912 |
T14906 |
punct |
”,presentation |
R9803 |
T14913 |
T14914 |
prep |
during,rewarded |
R9804 |
T14914 |
T14906 |
relcl |
rewarded,presentation |
R9805 |
T14915 |
T14913 |
pobj |
which,during |
R9806 |
T14916 |
T14917 |
det |
a,lick |
R9807 |
T14917 |
T14914 |
nsubjpass |
lick,rewarded |
R9808 |
T14918 |
T14914 |
auxpass |
was,rewarded |
R9809 |
T14919 |
T14892 |
punct |
.,entered |
R9810 |
T14921 |
T14922 |
det |
The,odorant |
R9811 |
T14922 |
T14924 |
nsubj |
odorant,was |
R9812 |
T14923 |
T14922 |
punct |
“,odorant |
R9813 |
T14925 |
T14922 |
punct |
”,odorant |
R9814 |
T14926 |
T14922 |
acl |
used,odorant |
R9815 |
T14927 |
T14926 |
prep |
in,used |
R9816 |
T14928 |
T14929 |
det |
the,pretraining |
R9817 |
T14929 |
T14927 |
pobj |
pretraining,in |
R9818 |
T14930 |
T14931 |
det |
the,medium |
R9819 |
T14931 |
T14924 |
attr |
medium,was |
R9820 |
T14932 |
T14931 |
compound |
carrier,medium |
R9821 |
T14933 |
T14934 |
compound |
mineral,oil |
R9822 |
T14934 |
T14931 |
appos |
oil,medium |
R9823 |
T14935 |
T14924 |
punct |
.,was |
R9824 |
T14937 |
T14938 |
det |
All,animals |
R9825 |
T14938 |
T14939 |
nsubj |
animals,learned |
R9826 |
T14940 |
T14941 |
det |
this,task |
R9827 |
T14941 |
T14939 |
dobj |
task,learned |
R9828 |
T14942 |
T14939 |
prep |
within,learned |
R9829 |
T14943 |
T14944 |
nummod |
one,day |
R9830 |
T14944 |
T14942 |
pobj |
day,within |
R9831 |
T14945 |
T14946 |
punct |
(,sessions |
R9832 |
T14946 |
T14944 |
parataxis |
sessions,day |
R9833 |
T14947 |
T14948 |
quantmod |
2,3 |
R9834 |
T14948 |
T14946 |
nummod |
3,sessions |
R9835 |
T14949 |
T14948 |
punct |
–,3 |
R9836 |
T14950 |
T14951 |
nummod |
30,min |
R9837 |
T14951 |
T14946 |
npadvmod |
min,sessions |
R9838 |
T14952 |
T14951 |
appos |
each,min |
R9839 |
T14953 |
T14946 |
punct |
),sessions |
R9840 |
T14954 |
T14939 |
punct |
.,learned |
R9841 |
T14985 |
T14984 |
prep |
of,Structure |
R9842 |
T14986 |
T14987 |
det |
an,trial |
R9843 |
T14987 |
T14985 |
pobj |
trial,of |
R9844 |
T14988 |
T14987 |
amod |
individual,trial |
R9845 |
T14990 |
T14991 |
det |
The,mouse |
R9846 |
T14991 |
T14992 |
nsubj |
mouse,initiates |
R9847 |
T14993 |
T14994 |
det |
each,trial |
R9848 |
T14994 |
T14992 |
dobj |
trial,initiates |
R9849 |
T14995 |
T14992 |
prep |
by,initiates |
R9850 |
T14996 |
T14995 |
pcomp |
breaking,by |
R9851 |
T14997 |
T14998 |
det |
a,barrier |
R9852 |
T14998 |
T14996 |
dobj |
barrier,breaking |
R9853 |
T14999 |
T14998 |
compound |
light,barrier |
R9854 |
T15000 |
T14996 |
prep |
at,breaking |
R9855 |
T15001 |
T15002 |
det |
the,opening |
R9856 |
T15002 |
T15000 |
pobj |
opening,at |
R9857 |
T15003 |
T15002 |
prep |
of,opening |
R9858 |
T15004 |
T15005 |
det |
the,port |
R9859 |
T15005 |
T15003 |
pobj |
port,of |
R9860 |
T15006 |
T15005 |
compound |
sampling,port |
R9861 |
T15007 |
T15008 |
punct |
(,see |
R9862 |
T15008 |
T14992 |
parataxis |
see,initiates |
R9863 |
T15009 |
T15008 |
advmod |
also,see |
R9864 |
T15010 |
T15008 |
punct |
[,see |
R9865 |
T15011 |
T15008 |
dobj |
3,see |
R9866 |
T15012 |
T15008 |
punct |
],see |
R9867 |
T15013 |
T15008 |
punct |
),see |
R9868 |
T15014 |
T14992 |
punct |
.,initiates |
R9869 |
T15016 |
T15017 |
nsubj |
This,opens |
R9870 |
T15018 |
T15017 |
dobj |
one,opens |
R9871 |
T15019 |
T15018 |
prep |
of,one |
R9872 |
T15020 |
T15021 |
nummod |
eight,valves |
R9873 |
T15021 |
T15019 |
pobj |
valves,of |
R9874 |
T15022 |
T15021 |
compound |
odor,valves |
R9875 |
T15023 |
T15021 |
punct |
", ",valves |
R9876 |
T15024 |
T15021 |
cc |
and,valves |
R9877 |
T15025 |
T15026 |
det |
a,valve |
R9878 |
T15026 |
T15021 |
conj |
valve,valves |
R9879 |
T15027 |
T15026 |
compound |
diversion,valve |
R9880 |
T15028 |
T15029 |
dep |
that,diverts |
R9881 |
T15029 |
T15026 |
relcl |
diverts,valve |
R9882 |
T15030 |
T15031 |
det |
all,flow |
R9883 |
T15031 |
T15029 |
dobj |
flow,diverts |
R9884 |
T15032 |
T15031 |
compound |
air,flow |
R9885 |
T15033 |
T15029 |
advmod |
away,diverts |
R9886 |
T15034 |
T15033 |
prep |
from,away |
R9887 |
T15035 |
T15036 |
det |
the,animal |
R9888 |
T15036 |
T15034 |
pobj |
animal,from |
R9889 |
T15037 |
T15029 |
prep |
for,diverts |
R9890 |
T15038 |
T15039 |
advmod |
typically,ms |
R9891 |
T15039 |
T15037 |
pobj |
ms,for |
R9892 |
T15040 |
T15039 |
nummod |
500,ms |
R9893 |
T15041 |
T15017 |
punct |
.,opens |
R9894 |
T15043 |
T15044 |
prep |
After,is |
R9895 |
T15045 |
T15046 |
det |
the,release |
R9896 |
T15046 |
T15043 |
pobj |
release,After |
R9897 |
T15047 |
T15046 |
prep |
of,release |
R9898 |
T15048 |
T15049 |
det |
the,valve |
R9899 |
T15049 |
T15047 |
pobj |
valve,of |
R9900 |
T15050 |
T15049 |
compound |
diversion,valve |
R9901 |
T15051 |
T15044 |
punct |
", ",is |
R9902 |
T15052 |
T15053 |
det |
the,odor |
R9903 |
T15053 |
T15044 |
nsubj |
odor,is |
R9904 |
T15054 |
T15044 |
acomp |
accessible,is |
R9905 |
T15055 |
T15054 |
prep |
to,accessible |
R9906 |
T15056 |
T15057 |
det |
the,animal |
R9907 |
T15057 |
T15055 |
pobj |
animal,to |
R9908 |
T15058 |
T15044 |
prep |
for,is |
R9909 |
T15059 |
T15060 |
nummod |
"2,000",ms |
R9910 |
T15060 |
T15058 |
pobj |
ms,for |
R9911 |
T15061 |
T15044 |
punct |
.,is |
R9912 |
T15063 |
T15064 |
mark |
If,licks |
R9913 |
T15064 |
T15067 |
advcl |
licks,receive |
R9914 |
T15065 |
T15064 |
nsubj |
it,licks |
R9915 |
T15066 |
T15064 |
advmod |
continuously,licks |
R9916 |
T15068 |
T15064 |
prep |
at,licks |
R9917 |
T15069 |
T15070 |
det |
the,port |
R9918 |
T15070 |
T15068 |
pobj |
port,at |
R9919 |
T15071 |
T15070 |
compound |
lick,port |
R9920 |
T15072 |
T15064 |
prep |
during,licks |
R9921 |
T15073 |
T15074 |
det |
this,time |
R9922 |
T15074 |
T15072 |
pobj |
time,during |
R9923 |
T15075 |
T15076 |
punct |
(,in |
R9924 |
T15076 |
T15064 |
parataxis |
in,licks |
R9925 |
T15077 |
T15076 |
advmod |
once,in |
R9926 |
T15078 |
T15079 |
advmod |
at,least |
R9927 |
T15079 |
T15080 |
advmod |
least,four |
R9928 |
T15080 |
T15084 |
nummod |
four,bins |
R9929 |
T15081 |
T15080 |
quantmod |
three,four |
R9930 |
T15082 |
T15080 |
quantmod |
out,four |
R9931 |
T15083 |
T15080 |
quantmod |
of,four |
R9932 |
T15084 |
T15076 |
pobj |
bins,in |
R9933 |
T15085 |
T15086 |
nummod |
500,ms |
R9934 |
T15086 |
T15084 |
compound |
ms,bins |
R9935 |
T15087 |
T15086 |
punct |
-,ms |
R9936 |
T15088 |
T15076 |
punct |
),in |
R9937 |
T15089 |
T15067 |
punct |
", ",receive |
R9938 |
T15090 |
T15067 |
nsubj |
it,receive |
R9939 |
T15091 |
T15067 |
aux |
can,receive |
R9940 |
T15092 |
T15093 |
det |
a,reward |
R9941 |
T15093 |
T15067 |
dobj |
reward,receive |
R9942 |
T15094 |
T15095 |
quantmod |
2,4 |
R9943 |
T15095 |
T15098 |
nummod |
4,μl |
R9944 |
T15096 |
T15095 |
punct |
-,4 |
R9945 |
T15097 |
T15095 |
quantmod |
to,4 |
R9946 |
T15098 |
T15093 |
compound |
μl,reward |
R9947 |
T15099 |
T15098 |
punct |
-,μl |
R9948 |
T15100 |
T15093 |
compound |
water,reward |
R9949 |
T15101 |
T15067 |
prep |
after,receive |
R9950 |
T15102 |
T15103 |
det |
the,end |
R9951 |
T15103 |
T15101 |
pobj |
end,after |
R9952 |
T15104 |
T15103 |
prep |
of,end |
R9953 |
T15105 |
T15106 |
det |
the,period |
R9954 |
T15106 |
T15104 |
pobj |
period,of |
R9955 |
T15107 |
T15108 |
nummod |
"2,000",ms |
R9956 |
T15108 |
T15106 |
compound |
ms,period |
R9957 |
T15109 |
T15108 |
punct |
-,ms |
R9958 |
T15110 |
T15067 |
punct |
.,receive |
R9959 |
T15112 |
T15113 |
mark |
If,lick |
R9960 |
T15113 |
T15119 |
advcl |
lick,given |
R9961 |
T15114 |
T15115 |
det |
the,animal |
R9962 |
T15115 |
T15113 |
nsubj |
animal,lick |
R9963 |
T15116 |
T15113 |
aux |
does,lick |
R9964 |
T15117 |
T15113 |
neg |
not,lick |
R9965 |
T15118 |
T15113 |
advmod |
continuously,lick |
R9966 |
T15120 |
T15113 |
punct |
", ",lick |
R9967 |
T15121 |
T15113 |
cc |
or,lick |
R9968 |
T15122 |
T15123 |
mark |
if,was |
R9969 |
T15123 |
T15113 |
conj |
was,lick |
R9970 |
T15124 |
T15125 |
det |
the,odor |
R9971 |
T15125 |
T15123 |
nsubj |
odor,was |
R9972 |
T15126 |
T15125 |
amod |
presented,odor |
R9973 |
T15127 |
T15128 |
det |
a,odor |
R9974 |
T15128 |
T15123 |
attr |
odor,was |
R9975 |
T15129 |
T15128 |
amod |
designated,odor |
R9976 |
T15130 |
T15128 |
amod |
nonrewarded,odor |
R9977 |
T15131 |
T15119 |
punct |
", ",given |
R9978 |
T15132 |
T15133 |
preconj |
neither,reward |
R9979 |
T15133 |
T15119 |
nsubjpass |
reward,given |
R9980 |
T15134 |
T15133 |
det |
a,reward |
R9981 |
T15135 |
T15119 |
auxpass |
is,given |
R9982 |
T15136 |
T15137 |
cc |
nor,sort |
R9983 |
T15137 |
T15119 |
dep |
sort,given |
R9984 |
T15138 |
T15137 |
det |
any,sort |
R9985 |
T15139 |
T15137 |
prep |
of,sort |
R9986 |
T15140 |
T15139 |
pobj |
punishment,of |
R9987 |
T15141 |
T15119 |
punct |
", ",given |
R9988 |
T15142 |
T15143 |
aux |
to,minimize |
R9989 |
T15143 |
T15119 |
advcl |
minimize,given |
R9990 |
T15144 |
T15143 |
dobj |
stress,minimize |
R9991 |
T15145 |
T15143 |
prep |
for,minimize |
R9992 |
T15146 |
T15147 |
det |
the,animal |
R9993 |
T15147 |
T15145 |
pobj |
animal,for |
R9994 |
T15148 |
T15119 |
punct |
.,given |
R9995 |
T15150 |
T15151 |
nsubjpass |
Trials,counted |
R9996 |
T15152 |
T15151 |
auxpass |
are,counted |
R9997 |
T15153 |
T15151 |
prep |
as,counted |
R9998 |
T15154 |
T15153 |
amod |
correct,as |
R9999 |
T15155 |
T15156 |
mark |
if,licks |
R10000 |
T15156 |
T15151 |
advcl |
licks,counted |
R10001 |
T15157 |
T15158 |
det |
the,animal |
R10002 |
T15158 |
T15156 |
nsubj |
animal,licks |
R10003 |
T15159 |
T15156 |
advmod |
continuously,licks |
R10004 |
T15160 |
T15156 |
prep |
upon,licks |
R10005 |
T15161 |
T15160 |
pobj |
presentation,upon |
R10006 |
T15162 |
T15161 |
prep |
of,presentation |
R10007 |
T15163 |
T15164 |
det |
a,odor |
R10008 |
T15164 |
T15162 |
pobj |
odor,of |
R10009 |
T15165 |
T15164 |
amod |
rewarded,odor |
R10010 |
T15166 |
T15156 |
cc |
or,licks |
R10011 |
T15167 |
T15168 |
aux |
does,lick |
R10012 |
T15168 |
T15156 |
conj |
lick,licks |
R10013 |
T15169 |
T15168 |
neg |
not,lick |
R10014 |
T15170 |
T15168 |
advmod |
continuously,lick |
R10015 |
T15171 |
T15168 |
prep |
with,lick |
R10016 |
T15172 |
T15173 |
det |
a,odor |
R10017 |
T15173 |
T15171 |
pobj |
odor,with |
R10018 |
T15174 |
T15173 |
amod |
nonrewarded,odor |
R10019 |
T15175 |
T15151 |
punct |
.,counted |
R10020 |
T15177 |
T15178 |
det |
A,trial |
R10021 |
T15178 |
T15180 |
nsubjpass |
trial,initiated |
R10022 |
T15179 |
T15178 |
amod |
second,trial |
R10023 |
T15181 |
T15180 |
aux |
can,initiated |
R10024 |
T15182 |
T15180 |
neg |
not,initiated |
R10025 |
T15183 |
T15180 |
auxpass |
be,initiated |
R10026 |
T15184 |
T15185 |
mark |
unless,passed |
R10027 |
T15185 |
T15180 |
advcl |
passed,initiated |
R10028 |
T15186 |
T15187 |
det |
an,interval |
R10029 |
T15187 |
T15185 |
nsubj |
interval,passed |
R10030 |
T15188 |
T15187 |
amod |
intertrial,interval |
R10031 |
T15189 |
T15187 |
prep |
of,interval |
R10032 |
T15190 |
T15191 |
advmod |
at,least |
R10033 |
T15191 |
T15192 |
advmod |
least,5 |
R10034 |
T15192 |
T15193 |
nummod |
5,s |
R10035 |
T15193 |
T15189 |
pobj |
s,of |
R10036 |
T15194 |
T15185 |
aux |
has,passed |
R10037 |
T15195 |
T15180 |
punct |
.,initiated |
R10038 |
T15197 |
T15198 |
det |
This,interval |
R10039 |
T15198 |
T15199 |
nsubj |
interval,is |
R10040 |
T15200 |
T15201 |
advmod |
sufficiently,long |
R10041 |
T15201 |
T15199 |
acomp |
long,is |
R10042 |
T15202 |
T15203 |
advmod |
so,retract |
R10043 |
T15203 |
T15199 |
advcl |
retract,is |
R10044 |
T15204 |
T15203 |
mark |
that,retract |
R10045 |
T15205 |
T15203 |
nsubj |
animals,retract |
R10046 |
T15206 |
T15203 |
advmod |
typically,retract |
R10047 |
T15207 |
T15203 |
advmod |
quickly,retract |
R10048 |
T15208 |
T15203 |
prep |
after,retract |
R10049 |
T15209 |
T15210 |
det |
the,end |
R10050 |
T15210 |
T15208 |
pobj |
end,after |
R10051 |
T15211 |
T15210 |
prep |
of,end |
R10052 |
T15212 |
T15213 |
det |
the,trial |
R10053 |
T15213 |
T15211 |
pobj |
trial,of |
R10054 |
T15214 |
T15199 |
punct |
.,is |
R10055 |
T15216 |
T15217 |
nsubjpass |
Odors,presented |
R10056 |
T15218 |
T15217 |
auxpass |
are,presented |
R10057 |
T15219 |
T15217 |
prep |
in,presented |
R10058 |
T15220 |
T15221 |
det |
a,scheme |
R10059 |
T15221 |
T15219 |
pobj |
scheme,in |
R10060 |
T15222 |
T15221 |
amod |
pseudo-randomized,scheme |
R10061 |
T15223 |
T15224 |
punct |
(,numbers |
R10062 |
T15224 |
T15217 |
parataxis |
numbers,presented |
R10063 |
T15225 |
T15226 |
quantmod |
no,two |
R10064 |
T15226 |
T15229 |
nummod |
two,presentations |
R10065 |
T15227 |
T15226 |
amod |
more,two |
R10066 |
T15228 |
T15226 |
quantmod |
than,two |
R10067 |
T15229 |
T15224 |
dep |
presentations,numbers |
R10068 |
T15230 |
T15229 |
amod |
successive,presentations |
R10069 |
T15231 |
T15229 |
prep |
of,presentations |
R10070 |
T15232 |
T15233 |
det |
the,odor |
R10071 |
T15233 |
T15231 |
pobj |
odor,of |
R10072 |
T15234 |
T15233 |
amod |
same,odor |
R10073 |
T15235 |
T15224 |
punct |
", ",numbers |
R10074 |
T15236 |
T15224 |
amod |
equal,numbers |
R10075 |
T15237 |
T15224 |
prep |
within,numbers |
R10076 |
T15238 |
T15239 |
det |
each,block |
R10077 |
T15239 |
T15237 |
pobj |
block,within |
R10078 |
T15240 |
T15241 |
nummod |
20,trial |
R10079 |
T15241 |
T15239 |
compound |
trial,block |
R10080 |
T15242 |
T15241 |
punct |
-,trial |
R10081 |
T15243 |
T15224 |
punct |
),numbers |
R10082 |
T15244 |
T15217 |
punct |
.,presented |
R10083 |
T15246 |
T15247 |
det |
No,preference |
R10084 |
T15247 |
T15249 |
nsubjpass |
preference,observed |
R10085 |
T15248 |
T15247 |
amod |
intrinsic,preference |
R10086 |
T15250 |
T15247 |
prep |
toward,preference |
R10087 |
T15251 |
T15250 |
pobj |
any,toward |
R10088 |
T15252 |
T15251 |
prep |
of,any |
R10089 |
T15253 |
T15254 |
det |
the,odors |
R10090 |
T15254 |
T15252 |
pobj |
odors,of |
R10091 |
T15255 |
T15249 |
auxpass |
was,observed |
R10092 |
T15256 |
T15249 |
cc |
but,observed |
R10093 |
T15257 |
T15249 |
conj |
controlled,observed |
R10094 |
T15258 |
T15257 |
prep |
for,controlled |
R10095 |
T15259 |
T15257 |
prep |
by,controlled |
R10096 |
T15260 |
T15259 |
pobj |
counterbalancing,by |
R10097 |
T15261 |
T15249 |
punct |
.,observed |
R10098 |
T15263 |
T15264 |
quantmod |
A,300 |
R10099 |
T15264 |
T15269 |
nummod |
300,trials |
R10100 |
T15265 |
T15264 |
quantmod |
total,300 |
R10101 |
T15266 |
T15264 |
quantmod |
of,300 |
R10102 |
T15267 |
T15264 |
quantmod |
100,300 |
R10103 |
T15268 |
T15264 |
punct |
–,300 |
R10104 |
T15269 |
T15270 |
nsubjpass |
trials,separated |
R10105 |
T15271 |
T15270 |
auxpass |
were,separated |
R10106 |
T15272 |
T15270 |
aux |
performed,separated |
R10107 |
T15273 |
T15274 |
det |
each,day |
R10108 |
T15274 |
T15270 |
npadvmod |
day,separated |
R10109 |
T15275 |
T15270 |
punct |
", ",separated |
R10110 |
T15276 |
T15270 |
prep |
into,separated |
R10111 |
T15277 |
T15278 |
quantmod |
30,40 |
R10112 |
T15278 |
T15281 |
nummod |
40,min |
R10113 |
T15279 |
T15278 |
punct |
-,40 |
R10114 |
T15280 |
T15278 |
quantmod |
to,40 |
R10115 |
T15281 |
T15283 |
compound |
min,stretches |
R10116 |
T15282 |
T15281 |
punct |
-,min |
R10117 |
T15283 |
T15276 |
pobj |
stretches,into |
R10118 |
T15284 |
T15285 |
aux |
to,ensure |
R10119 |
T15285 |
T15270 |
advcl |
ensure,separated |
R10120 |
T15286 |
T15287 |
amod |
maximal,motivation |
R10121 |
T15287 |
T15285 |
dobj |
motivation,ensure |
R10122 |
T15288 |
T15285 |
prep |
despite,ensure |
R10123 |
T15289 |
T15290 |
det |
the,scheme |
R10124 |
T15290 |
T15288 |
pobj |
scheme,despite |
R10125 |
T15291 |
T15290 |
amod |
mild,scheme |
R10126 |
T15292 |
T15293 |
compound |
water,restriction |
R10127 |
T15293 |
T15290 |
compound |
restriction,scheme |
R10128 |
T15294 |
T15270 |
punct |
.,separated |
R10129 |
T15296 |
T15297 |
advmod |
Additionally,controlled |
R10130 |
T15298 |
T15297 |
punct |
", ",controlled |
R10131 |
T15299 |
T15297 |
nsubjpass |
motivation,controlled |
R10132 |
T15300 |
T15297 |
auxpass |
was,controlled |
R10133 |
T15301 |
T15297 |
prep |
by,controlled |
R10134 |
T15302 |
T15301 |
pcomp |
monitoring,by |
R10135 |
T15303 |
T15304 |
amod |
intertrial,intervals |
R10136 |
T15304 |
T15302 |
dobj |
intervals,monitoring |
R10137 |
T15305 |
T15304 |
cc |
and,intervals |
R10138 |
T15306 |
T15307 |
det |
the,frequency |
R10139 |
T15307 |
T15304 |
conj |
frequency,intervals |
R10140 |
T15308 |
T15307 |
compound |
response,frequency |
R10141 |
T15309 |
T15310 |
punct |
[,3 |
R10142 |
T15310 |
T15297 |
parataxis |
3,controlled |
R10143 |
T15311 |
T15310 |
punct |
],3 |
R10144 |
T15312 |
T15297 |
punct |
.,controlled |
R10145 |
T15339 |
T15338 |
prep |
of,Measurement |
R10146 |
T15340 |
T15339 |
pobj |
performance,of |
R10147 |
T15342 |
T15343 |
det |
The,measure |
R10148 |
T15343 |
T15345 |
nsubj |
measure,is |
R10149 |
T15344 |
T15343 |
amod |
simplest,measure |
R10150 |
T15346 |
T15343 |
prep |
of,measure |
R10151 |
T15347 |
T15346 |
pobj |
performance,of |
R10152 |
T15348 |
T15349 |
det |
the,fraction |
R10153 |
T15349 |
T15345 |
attr |
fraction,is |
R10154 |
T15350 |
T15349 |
prep |
of,fraction |
R10155 |
T15351 |
T15350 |
pobj |
trials,of |
R10156 |
T15352 |
T15353 |
prep |
in,responds |
R10157 |
T15353 |
T15349 |
relcl |
responds,fraction |
R10158 |
T15354 |
T15352 |
pobj |
which,in |
R10159 |
T15355 |
T15356 |
det |
the,animal |
R10160 |
T15356 |
T15353 |
nsubj |
animal,responds |
R10161 |
T15357 |
T15353 |
advmod |
correctly,responds |
R10162 |
T15358 |
T15353 |
punct |
—,responds |
R10163 |
T15359 |
T15360 |
advmod |
that,is |
R10164 |
T15360 |
T15361 |
advmod |
is,responds |
R10165 |
T15361 |
T15353 |
dep |
responds,responds |
R10166 |
T15362 |
T15361 |
punct |
", ",responds |
R10167 |
T15363 |
T15361 |
prep |
with,responds |
R10168 |
T15364 |
T15363 |
pobj |
licking,with |
R10169 |
T15365 |
T15361 |
prep |
to,responds |
R10170 |
T15366 |
T15367 |
det |
the,presentation |
R10171 |
T15367 |
T15365 |
pobj |
presentation,to |
R10172 |
T15368 |
T15367 |
prep |
of,presentation |
R10173 |
T15369 |
T15370 |
det |
the,odor |
R10174 |
T15370 |
T15368 |
pobj |
odor,of |
R10175 |
T15371 |
T15370 |
nmod |
S,odor |
R10176 |
T15372 |
T15371 |
punct |
+,S |
R10177 |
T15373 |
T15361 |
cc |
and,responds |
R10178 |
T15374 |
T15375 |
aux |
does,lick |
R10179 |
T15375 |
T15361 |
conj |
lick,responds |
R10180 |
T15376 |
T15375 |
neg |
not,lick |
R10181 |
T15377 |
T15375 |
prep |
with,lick |
R10182 |
T15378 |
T15377 |
pobj |
presentation,with |
R10183 |
T15379 |
T15378 |
prep |
of,presentation |
R10184 |
T15380 |
T15381 |
det |
the,odor |
R10185 |
T15381 |
T15379 |
pobj |
odor,of |
R10186 |
T15382 |
T15381 |
nmod |
S,odor |
R10187 |
T15383 |
T15381 |
punct |
−,odor |
R10188 |
T15384 |
T15345 |
punct |
.,is |
R10189 |
T15386 |
T15387 |
nsubjpass |
It,shown |
R10190 |
T15388 |
T15387 |
auxpass |
was,shown |
R10191 |
T15389 |
T15387 |
advmod |
previously,shown |
R10192 |
T15390 |
T15387 |
punct |
", ",shown |
R10193 |
T15391 |
T15387 |
advmod |
however,shown |
R10194 |
T15392 |
T15387 |
punct |
", ",shown |
R10195 |
T15393 |
T15394 |
mark |
that,is |
R10196 |
T15394 |
T15387 |
ccomp |
is,shown |
R10197 |
T15395 |
T15396 |
det |
the,pattern |
R10198 |
T15396 |
T15394 |
nsubj |
pattern,is |
R10199 |
T15397 |
T15396 |
amod |
detailed,pattern |
R10200 |
T15398 |
T15396 |
compound |
sampling,pattern |
R10201 |
T15399 |
T15400 |
det |
a,measure |
R10202 |
T15400 |
T15394 |
attr |
measure,is |
R10203 |
T15401 |
T15402 |
advmod |
more,sensitive |
R10204 |
T15402 |
T15400 |
amod |
sensitive,measure |
R10205 |
T15403 |
T15400 |
prep |
of,measure |
R10206 |
T15404 |
T15405 |
compound |
discrimination,performance |
R10207 |
T15405 |
T15403 |
pobj |
performance,of |
R10208 |
T15406 |
T15407 |
punct |
[,3 |
R10209 |
T15407 |
T15387 |
parataxis |
3,shown |
R10210 |
T15408 |
T15407 |
punct |
],3 |
R10211 |
T15409 |
T15387 |
punct |
.,shown |
R10212 |
T15411 |
T15412 |
aux |
To,avoid |
R10213 |
T15412 |
T15413 |
advcl |
avoid,chose |
R10214 |
T15414 |
T15415 |
amod |
long,periods |
R10215 |
T15415 |
T15412 |
dobj |
periods,avoid |
R10216 |
T15416 |
T15417 |
punct |
(,week |
R10217 |
T15417 |
T15414 |
parataxis |
week,long |
R10218 |
T15418 |
T15419 |
punct |
>,3 |
R10219 |
T15419 |
T15417 |
nummod |
3,week |
R10220 |
T15420 |
T15417 |
punct |
-,week |
R10221 |
T15421 |
T15417 |
punct |
),week |
R10222 |
T15422 |
T15415 |
compound |
training,periods |
R10223 |
T15423 |
T15413 |
punct |
", ",chose |
R10224 |
T15424 |
T15413 |
nsubj |
we,chose |
R10225 |
T15425 |
T15426 |
neg |
not,measure |
R10226 |
T15426 |
T15413 |
xcomp |
measure,chose |
R10227 |
T15427 |
T15426 |
aux |
to,measure |
R10228 |
T15428 |
T15429 |
compound |
discrimination,times |
R10229 |
T15429 |
T15426 |
dobj |
times,measure |
R10230 |
T15430 |
T15431 |
punct |
[,3 |
R10231 |
T15431 |
T15426 |
parataxis |
3,measure |
R10232 |
T15432 |
T15431 |
punct |
],3 |
R10233 |
T15433 |
T15426 |
cc |
but,measure |
R10234 |
T15434 |
T15435 |
aux |
to,analyze |
R10235 |
T15435 |
T15426 |
conj |
analyze,measure |
R10236 |
T15436 |
T15437 |
det |
the,behavior |
R10237 |
T15437 |
T15435 |
dobj |
behavior,analyze |
R10238 |
T15438 |
T15437 |
amod |
average,behavior |
R10239 |
T15439 |
T15437 |
compound |
sampling,behavior |
R10240 |
T15440 |
T15435 |
prep |
in,analyze |
R10241 |
T15441 |
T15440 |
amod |
total,in |
R10242 |
T15442 |
T15413 |
punct |
.,chose |
R10243 |
T15444 |
T15445 |
prep |
Upon,breaks |
R10244 |
T15446 |
T15444 |
pobj |
presentation,Upon |
R10245 |
T15447 |
T15446 |
prep |
of,presentation |
R10246 |
T15448 |
T15449 |
det |
a,odor |
R10247 |
T15449 |
T15447 |
pobj |
odor,of |
R10248 |
T15450 |
T15449 |
amod |
rewarded,odor |
R10249 |
T15451 |
T15445 |
punct |
", ",breaks |
R10250 |
T15452 |
T15453 |
det |
the,animal |
R10251 |
T15453 |
T15445 |
nsubj |
animal,breaks |
R10252 |
T15454 |
T15445 |
advmod |
usually,breaks |
R10253 |
T15455 |
T15445 |
advmod |
continuously,breaks |
R10254 |
T15456 |
T15457 |
det |
the,beam |
R10255 |
T15457 |
T15445 |
dobj |
beam,breaks |
R10256 |
T15458 |
T15445 |
punct |
", ",breaks |
R10257 |
T15459 |
T15460 |
mark |
whereas,retracted |
R10258 |
T15460 |
T15445 |
advcl |
retracted,breaks |
R10259 |
T15461 |
T15460 |
prep |
upon,retracted |
R10260 |
T15462 |
T15461 |
pobj |
presentation,upon |
R10261 |
T15463 |
T15462 |
prep |
of,presentation |
R10262 |
T15464 |
T15465 |
det |
an,odor |
R10263 |
T15465 |
T15463 |
pobj |
odor,of |
R10264 |
T15466 |
T15465 |
amod |
unrewarded,odor |
R10265 |
T15467 |
T15468 |
det |
the,head |
R10266 |
T15468 |
T15460 |
nsubjpass |
head,retracted |
R10267 |
T15469 |
T15460 |
auxpass |
is,retracted |
R10268 |
T15470 |
T15460 |
advmod |
quickly,retracted |
R10269 |
T15471 |
T15445 |
punct |
.,breaks |
R10270 |
T15473 |
T15474 |
det |
The,difference |
R10271 |
T15474 |
T15475 |
nsubj |
difference,is |
R10272 |
T15476 |
T15474 |
prep |
in,difference |
R10273 |
T15477 |
T15476 |
pobj |
response,in |
R10274 |
T15478 |
T15477 |
prep |
to,response |
R10275 |
T15479 |
T15480 |
det |
the,odor |
R10276 |
T15480 |
T15478 |
pobj |
odor,to |
R10277 |
T15481 |
T15480 |
amod |
rewarded,odor |
R10278 |
T15482 |
T15481 |
cc |
and,rewarded |
R10279 |
T15483 |
T15481 |
conj |
unrewarded,rewarded |
R10280 |
T15484 |
T15485 |
advmod |
approximately,sigmoidal |
R10281 |
T15485 |
T15475 |
acomp |
sigmoidal,is |
R10282 |
T15486 |
T15487 |
punct |
(,1D |
R10283 |
T15487 |
T15475 |
parataxis |
1D,is |
R10284 |
T15488 |
T15487 |
compound |
Figures,1D |
R10285 |
T15489 |
T15487 |
punct |
", ",1D |
R10286 |
T15490 |
T15487 |
conj |
1E,1D |
R10287 |
T15491 |
T15490 |
punct |
", ",1E |
R10288 |
T15492 |
T15490 |
cc |
and,1E |
R10289 |
T15493 |
T15490 |
conj |
2D,1E |
R10290 |
T15494 |
T15487 |
punct |
),1D |
R10291 |
T15495 |
T15475 |
cc |
and,is |
R10292 |
T15496 |
T15475 |
conj |
yields,is |
R10293 |
T15497 |
T15498 |
det |
a,measure |
R10294 |
T15498 |
T15496 |
dobj |
measure,yields |
R10295 |
T15499 |
T15498 |
amod |
sensitive,measure |
R10296 |
T15500 |
T15498 |
prep |
of,measure |
R10297 |
T15501 |
T15502 |
det |
the,performance |
R10298 |
T15502 |
T15500 |
pobj |
performance,of |
R10299 |
T15503 |
T15502 |
compound |
discrimination,performance |
R10300 |
T15504 |
T15475 |
punct |
.,is |
R10301 |
T15506 |
T15507 |
prep |
From,determined |
R10302 |
T15508 |
T15509 |
det |
this,difference |
R10303 |
T15509 |
T15506 |
pobj |
difference,From |
R10304 |
T15510 |
T15506 |
cc |
or,From |
R10305 |
T15511 |
T15506 |
conj |
from,From |
R10306 |
T15512 |
T15513 |
det |
a,fit |
R10307 |
T15513 |
T15511 |
pobj |
fit,from |
R10308 |
T15514 |
T15513 |
amod |
sigmoidal,fit |
R10309 |
T15515 |
T15513 |
prep |
to,fit |
R10310 |
T15516 |
T15517 |
det |
the,difference |
R10311 |
T15517 |
T15515 |
pobj |
difference,to |
R10312 |
T15518 |
T15519 |
punct |
(,1E |
R10313 |
T15519 |
T15511 |
parataxis |
1E,from |
R10314 |
T15520 |
T15519 |
compound |
Figure,1E |
R10315 |
T15521 |
T15519 |
punct |
),1E |
R10316 |
T15522 |
T15507 |
punct |
", ",determined |
R10317 |
T15523 |
T15524 |
amod |
several,measures |
R10318 |
T15524 |
T15507 |
nsubjpass |
measures,determined |
R10319 |
T15525 |
T15524 |
prep |
of,measures |
R10320 |
T15526 |
T15525 |
pobj |
discrimination,of |
R10321 |
T15527 |
T15507 |
aux |
can,determined |
R10322 |
T15528 |
T15507 |
auxpass |
be,determined |
R10323 |
T15529 |
T15507 |
punct |
: ,determined |
R10324 |
T15530 |
T15531 |
det |
the,difference |
R10325 |
T15531 |
T15507 |
dobj |
difference,determined |
R10326 |
T15532 |
T15531 |
amod |
average,difference |
R10327 |
T15533 |
T15531 |
punct |
", ",difference |
R10328 |
T15534 |
T15535 |
nmod |
peak,time |
R10329 |
T15535 |
T15531 |
conj |
time,difference |
R10330 |
T15536 |
T15534 |
punct |
", ",peak |
R10331 |
T15537 |
T15534 |
cc |
or,peak |
R10332 |
T15538 |
T15534 |
conj |
maximum,peak |
R10333 |
T15539 |
T15535 |
punct |
", ",time |
R10334 |
T15540 |
T15535 |
prep |
of,time |
R10335 |
T15541 |
T15542 |
amod |
half,maximum |
R10336 |
T15542 |
T15540 |
pobj |
maximum,of |
R10337 |
T15543 |
T15535 |
punct |
", ",time |
R10338 |
T15544 |
T15535 |
cc |
and,time |
R10339 |
T15545 |
T15535 |
conj |
slope,time |
R10340 |
T15546 |
T15545 |
prep |
of,slope |
R10341 |
T15547 |
T15548 |
det |
the,sigmoid |
R10342 |
T15548 |
T15546 |
pobj |
sigmoid,of |
R10343 |
T15549 |
T15548 |
amod |
fitted,sigmoid |
R10344 |
T15550 |
T15507 |
punct |
.,determined |
R10345 |
T15552 |
T15553 |
mark |
Whereas,is |
R10346 |
T15553 |
T15565 |
advcl |
is,yielded |
R10347 |
T15554 |
T15553 |
prep |
for,is |
R10348 |
T15555 |
T15556 |
amod |
small,numbers |
R10349 |
T15556 |
T15554 |
pobj |
numbers,for |
R10350 |
T15557 |
T15556 |
compound |
trial,numbers |
R10351 |
T15558 |
T15559 |
punct |
(,200 |
R10352 |
T15559 |
T15556 |
parataxis |
200,numbers |
R10353 |
T15560 |
T15559 |
punct |
<,200 |
R10354 |
T15561 |
T15559 |
punct |
),200 |
R10355 |
T15562 |
T15563 |
det |
the,slope |
R10356 |
T15563 |
T15553 |
nsubj |
slope,is |
R10357 |
T15564 |
T15553 |
advmod |
often,is |
R10358 |
T15566 |
T15553 |
neg |
not,is |
R10359 |
T15567 |
T15568 |
advmod |
well,constrained |
R10360 |
T15568 |
T15553 |
acomp |
constrained,is |
R10361 |
T15569 |
T15565 |
punct |
", ",yielded |
R10362 |
T15570 |
T15565 |
nsubj |
any,yielded |
R10363 |
T15571 |
T15570 |
prep |
of,any |
R10364 |
T15572 |
T15573 |
det |
the,parameters |
R10365 |
T15573 |
T15571 |
pobj |
parameters,of |
R10366 |
T15574 |
T15573 |
amod |
other,parameters |
R10367 |
T15575 |
T15565 |
advmod |
essentially,yielded |
R10368 |
T15576 |
T15577 |
det |
the,results |
R10369 |
T15577 |
T15565 |
dobj |
results,yielded |
R10370 |
T15578 |
T15577 |
amod |
same,results |
R10371 |
T15579 |
T15565 |
punct |
.,yielded |
R10372 |
T15581 |
T15582 |
det |
The,index |
R10373 |
T15582 |
T15584 |
nsubj |
index,refers |
R10374 |
T15583 |
T15582 |
compound |
discrimination,index |
R10375 |
T15585 |
T15582 |
acl |
plotted,index |
R10376 |
T15586 |
T15585 |
prep |
in,plotted |
R10377 |
T15587 |
T15588 |
compound |
Figures,1F |
R10378 |
T15588 |
T15586 |
pobj |
1F,in |
R10379 |
T15589 |
T15588 |
punct |
", ",1F |
R10380 |
T15590 |
T15588 |
conj |
2C,1F |
R10381 |
T15591 |
T15590 |
punct |
", ",2C |
R10382 |
T15592 |
T15590 |
conj |
4D,2C |
R10383 |
T15593 |
T15592 |
punct |
", ",4D |
R10384 |
T15594 |
T15592 |
cc |
and,4D |
R10385 |
T15595 |
T15592 |
conj |
6C,4D |
R10386 |
T15596 |
T15584 |
prep |
to,refers |
R10387 |
T15597 |
T15598 |
det |
the,maximum |
R10388 |
T15598 |
T15596 |
pobj |
maximum,to |
R10389 |
T15599 |
T15598 |
amod |
fitted,maximum |
R10390 |
T15600 |
T15598 |
punct |
", ",maximum |
R10391 |
T15601 |
T15602 |
advmod |
generally,ranging |
R10392 |
T15602 |
T15598 |
acl |
ranging,maximum |
R10393 |
T15603 |
T15602 |
prep |
from,ranging |
R10394 |
T15604 |
T15603 |
pobj |
zero,from |
R10395 |
T15605 |
T15603 |
prep |
to,from |
R10396 |
T15606 |
T15605 |
pobj |
one,to |
R10397 |
T15607 |
T15602 |
punct |
", ",ranging |
R10398 |
T15608 |
T15609 |
nsubj |
one,indicating |
R10399 |
T15609 |
T15602 |
advcl |
indicating,ranging |
R10400 |
T15610 |
T15611 |
det |
the,discrimination |
R10401 |
T15611 |
T15609 |
dobj |
discrimination,indicating |
R10402 |
T15612 |
T15611 |
amod |
best,discrimination |
R10403 |
T15613 |
T15584 |
punct |
.,refers |
R10404 |
T15615 |
T15616 |
amod |
Identical,results |
R10405 |
T15616 |
T15617 |
nsubjpass |
results,obtained |
R10406 |
T15618 |
T15617 |
auxpass |
were,obtained |
R10407 |
T15619 |
T15617 |
prep |
with,obtained |
R10408 |
T15620 |
T15621 |
amod |
other,measures |
R10409 |
T15621 |
T15619 |
pobj |
measures,with |
R10410 |
T15622 |
T15621 |
prep |
of,measures |
R10411 |
T15623 |
T15622 |
pobj |
discrimination,of |
R10412 |
T15624 |
T15621 |
punct |
", ",measures |
R10413 |
T15625 |
T15626 |
amod |
such,as |
R10414 |
T15626 |
T15621 |
prep |
as,measures |
R10415 |
T15627 |
T15628 |
det |
the,difference |
R10416 |
T15628 |
T15626 |
pobj |
difference,as |
R10417 |
T15629 |
T15628 |
amod |
average,difference |
R10418 |
T15630 |
T15628 |
compound |
sampling,difference |
R10419 |
T15631 |
T15617 |
punct |
.,obtained |
R10420 |
T15660 |
T15659 |
prep |
of,Structure |
R10421 |
T15661 |
T15660 |
pobj |
training,of |
R10422 |
T15663 |
T15664 |
prep |
After,trained |
R10423 |
T15665 |
T15663 |
pobj |
habituation,After |
R10424 |
T15666 |
T15664 |
punct |
", ",trained |
R10425 |
T15667 |
T15664 |
nsubjpass |
mice,trained |
R10426 |
T15668 |
T15664 |
auxpass |
were,trained |
R10427 |
T15669 |
T15670 |
aux |
to,discriminate |
R10428 |
T15670 |
T15664 |
xcomp |
discriminate,trained |
R10429 |
T15671 |
T15672 |
nummod |
1,% |
R10430 |
T15672 |
T15673 |
compound |
%,amylacetate |
R10431 |
T15673 |
T15670 |
dobj |
amylacetate,discriminate |
R10432 |
T15674 |
T15670 |
prep |
from,discriminate |
R10433 |
T15675 |
T15676 |
nummod |
1,% |
R10434 |
T15676 |
T15677 |
compound |
%,ethylbutyrate |
R10435 |
T15677 |
T15674 |
pobj |
ethylbutyrate,from |
R10436 |
T15678 |
T15670 |
prep |
for,discriminate |
R10437 |
T15679 |
T15680 |
nummod |
500,trials |
R10438 |
T15680 |
T15678 |
pobj |
trials,for |
R10439 |
T15681 |
T15664 |
punct |
.,trained |
R10440 |
T15683 |
T15684 |
prep |
During,rewarded |
R10441 |
T15685 |
T15686 |
det |
the,trials |
R10442 |
T15686 |
T15683 |
pobj |
trials,During |
R10443 |
T15687 |
T15686 |
amod |
last,trials |
R10444 |
T15688 |
T15686 |
nummod |
100,trials |
R10445 |
T15689 |
T15684 |
punct |
", ",rewarded |
R10446 |
T15690 |
T15691 |
det |
the,odor |
R10447 |
T15691 |
T15684 |
nsubjpass |
odor,rewarded |
R10448 |
T15692 |
T15691 |
nmod |
S,odor |
R10449 |
T15693 |
T15692 |
punct |
+,S |
R10450 |
T15694 |
T15684 |
auxpass |
was,rewarded |
R10451 |
T15695 |
T15684 |
prep |
in,rewarded |
R10452 |
T15696 |
T15697 |
advmod |
only,50 |
R10453 |
T15697 |
T15698 |
nummod |
50,% |
R10454 |
T15698 |
T15695 |
pobj |
%,in |
R10455 |
T15699 |
T15698 |
prep |
of,% |
R10456 |
T15700 |
T15701 |
det |
the,cases |
R10457 |
T15701 |
T15699 |
pobj |
cases,of |
R10458 |
T15702 |
T15703 |
aux |
to,increase |
R10459 |
T15703 |
T15684 |
advcl |
increase,rewarded |
R10460 |
T15704 |
T15705 |
det |
the,resistance |
R10461 |
T15705 |
T15703 |
dobj |
resistance,increase |
R10462 |
T15706 |
T15705 |
prep |
to,resistance |
R10463 |
T15707 |
T15706 |
pobj |
extinction,to |
R10464 |
T15708 |
T15707 |
prep |
of,extinction |
R10465 |
T15709 |
T15710 |
det |
the,memory |
R10466 |
T15710 |
T15708 |
pobj |
memory,of |
R10467 |
T15711 |
T15710 |
amod |
acquired,memory |
R10468 |
T15712 |
T15684 |
punct |
.,rewarded |
R10469 |
T15714 |
T15715 |
det |
These,trials |
R10470 |
T15715 |
T15716 |
nsubjpass |
trials,excluded |
R10471 |
T15717 |
T15716 |
auxpass |
were,excluded |
R10472 |
T15718 |
T15716 |
prep |
for,excluded |
R10473 |
T15719 |
T15720 |
det |
the,analysis |
R10474 |
T15720 |
T15718 |
pobj |
analysis,for |
R10475 |
T15721 |
T15720 |
amod |
statistical,analysis |
R10476 |
T15722 |
T15720 |
prep |
of,analysis |
R10477 |
T15723 |
T15724 |
det |
the,curves |
R10478 |
T15724 |
T15722 |
pobj |
curves,of |
R10479 |
T15725 |
T15724 |
compound |
learning,curves |
R10480 |
T15726 |
T15716 |
punct |
.,excluded |
R10481 |
T15728 |
T15729 |
nsubj |
Inclusion,alter |
R10482 |
T15729 |
T15732 |
ccomp |
alter,was |
R10483 |
T15730 |
T15729 |
aux |
did,alter |
R10484 |
T15731 |
T15729 |
neg |
not,alter |
R10485 |
T15733 |
T15734 |
det |
the,result |
R10486 |
T15734 |
T15729 |
dobj |
result,alter |
R10487 |
T15735 |
T15734 |
prep |
of,result |
R10488 |
T15736 |
T15737 |
det |
the,ANOVA |
R10489 |
T15737 |
T15735 |
pobj |
ANOVA,of |
R10490 |
T15738 |
T15732 |
punct |
;,was |
R10491 |
T15739 |
T15732 |
advmod |
however,was |
R10492 |
T15740 |
T15732 |
punct |
", ",was |
R10493 |
T15741 |
T15742 |
amod |
linear,fitting |
R10494 |
T15742 |
T15732 |
nsubj |
fitting,was |
R10495 |
T15743 |
T15742 |
prep |
of,fitting |
R10496 |
T15744 |
T15745 |
det |
the,curve |
R10497 |
T15745 |
T15743 |
pobj |
curve,of |
R10498 |
T15746 |
T15745 |
compound |
learning,curve |
R10499 |
T15747 |
T15732 |
neg |
not,was |
R10500 |
T15748 |
T15732 |
acomp |
appropriate,was |
R10501 |
T15749 |
T15732 |
advmod |
anymore,was |
R10502 |
T15750 |
T15751 |
mark |
as,occurred |
R10503 |
T15751 |
T15732 |
advcl |
occurred,was |
R10504 |
T15752 |
T15753 |
amod |
partial,saturation |
R10505 |
T15753 |
T15751 |
nsubj |
saturation,occurred |
R10506 |
T15754 |
T15753 |
prep |
of,saturation |
R10507 |
T15755 |
T15756 |
compound |
learning,performance |
R10508 |
T15756 |
T15754 |
pobj |
performance,of |
R10509 |
T15757 |
T15751 |
aux |
had,occurred |
R10510 |
T15758 |
T15751 |
advmod |
already,occurred |
R10511 |
T15759 |
T15732 |
punct |
.,was |
R10512 |
T15761 |
T15762 |
advmod |
Subsequently,trained |
R10513 |
T15763 |
T15762 |
punct |
", ",trained |
R10514 |
T15764 |
T15762 |
nsubjpass |
animals,trained |
R10515 |
T15765 |
T15762 |
auxpass |
were,trained |
R10516 |
T15766 |
T15762 |
prep |
for,trained |
R10517 |
T15767 |
T15768 |
nummod |
500,trials |
R10518 |
T15768 |
T15766 |
pobj |
trials,for |
R10519 |
T15769 |
T15762 |
prep |
on,trained |
R10520 |
T15770 |
T15771 |
det |
the,task |
R10521 |
T15771 |
T15769 |
pobj |
task,on |
R10522 |
T15772 |
T15771 |
punct |
“,task |
R10523 |
T15773 |
T15771 |
amod |
difficult,task |
R10524 |
T15774 |
T15771 |
punct |
”,task |
R10525 |
T15775 |
T15771 |
compound |
discrimination,task |
R10526 |
T15776 |
T15777 |
punct |
[,3 |
R10527 |
T15777 |
T15771 |
parataxis |
3,task |
R10528 |
T15778 |
T15777 |
punct |
],3 |
R10529 |
T15779 |
T15771 |
prep |
between,task |
R10530 |
T15780 |
T15781 |
det |
the,mixtures |
R10531 |
T15781 |
T15779 |
pobj |
mixtures,between |
R10532 |
T15782 |
T15781 |
amod |
binary,mixtures |
R10533 |
T15783 |
T15784 |
nummod |
0.6,% |
R10534 |
T15784 |
T15785 |
compound |
%,eugenol |
R10535 |
T15785 |
T15781 |
appos |
eugenol,mixtures |
R10536 |
T15786 |
T15785 |
punct |
/,eugenol |
R10537 |
T15787 |
T15788 |
nummod |
0.4,% |
R10538 |
T15788 |
T15789 |
compound |
%,cineol |
R10539 |
T15789 |
T15785 |
appos |
cineol,eugenol |
R10540 |
T15790 |
T15785 |
cc |
and,eugenol |
R10541 |
T15791 |
T15792 |
nummod |
0.4,% |
R10542 |
T15792 |
T15793 |
compound |
%,eugenol |
R10543 |
T15793 |
T15785 |
conj |
eugenol,eugenol |
R10544 |
T15794 |
T15793 |
punct |
/,eugenol |
R10545 |
T15795 |
T15796 |
nummod |
0.6,% |
R10546 |
T15796 |
T15797 |
compound |
%,cineol |
R10547 |
T15797 |
T15793 |
appos |
cineol,eugenol |
R10548 |
T15798 |
T15762 |
punct |
.,trained |
R10549 |
T15800 |
T15801 |
aux |
To,allow |
R10550 |
T15801 |
T15802 |
advcl |
allow,altered |
R10551 |
T15803 |
T15801 |
dobj |
comparison,allow |
R10552 |
T15804 |
T15802 |
punct |
", ",altered |
R10553 |
T15805 |
T15806 |
det |
the,trials |
R10554 |
T15806 |
T15802 |
nsubjpass |
trials,altered |
R10555 |
T15807 |
T15806 |
amod |
last,trials |
R10556 |
T15808 |
T15806 |
nummod |
100,trials |
R10557 |
T15809 |
T15802 |
auxpass |
were,altered |
R10558 |
T15810 |
T15802 |
prep |
as,altered |
R10559 |
T15811 |
T15810 |
prep |
for,as |
R10560 |
T15812 |
T15813 |
det |
the,task |
R10561 |
T15813 |
T15811 |
pobj |
task,for |
R10562 |
T15814 |
T15813 |
punct |
“,task |
R10563 |
T15815 |
T15813 |
amod |
simple,task |
R10564 |
T15816 |
T15813 |
punct |
”,task |
R10565 |
T15817 |
T15813 |
compound |
discrimination,task |
R10566 |
T15818 |
T15813 |
advmod |
above,task |
R10567 |
T15819 |
T15802 |
punct |
.,altered |
R10568 |
T15821 |
T15822 |
prep |
After,trained |
R10569 |
T15823 |
T15824 |
nummod |
two,days |
R10570 |
T15824 |
T15821 |
pobj |
days,After |
R10571 |
T15825 |
T15824 |
prep |
of,days |
R10572 |
T15826 |
T15825 |
pobj |
rest,of |
R10573 |
T15827 |
T15822 |
punct |
", ",trained |
R10574 |
T15828 |
T15822 |
nsubjpass |
animals,trained |
R10575 |
T15829 |
T15822 |
auxpass |
were,trained |
R10576 |
T15830 |
T15822 |
advmod |
finally,trained |
R10577 |
T15831 |
T15822 |
prep |
on,trained |
R10578 |
T15832 |
T15833 |
det |
the,task |
R10579 |
T15833 |
T15831 |
pobj |
task,on |
R10580 |
T15834 |
T15833 |
punct |
“,task |
R10581 |
T15835 |
T15833 |
amod |
simple,task |
R10582 |
T15836 |
T15833 |
punct |
”,task |
R10583 |
T15837 |
T15833 |
compound |
discrimination,task |
R10584 |
T15838 |
T15833 |
prep |
between,task |
R10585 |
T15839 |
T15840 |
nummod |
1,% |
R10586 |
T15840 |
T15841 |
nmod |
%,acid |
R10587 |
T15841 |
T15838 |
pobj |
acid,between |
R10588 |
T15842 |
T15841 |
amod |
pelargonic,acid |
R10589 |
T15843 |
T15841 |
cc |
and,acid |
R10590 |
T15844 |
T15845 |
nummod |
1,% |
R10591 |
T15845 |
T15846 |
nmod |
%,acid |
R10592 |
T15846 |
T15841 |
conj |
acid,acid |
R10593 |
T15847 |
T15846 |
amod |
valeric,acid |
R10594 |
T15848 |
T15822 |
prep |
for,trained |
R10595 |
T15849 |
T15850 |
det |
another,trials |
R10596 |
T15850 |
T15848 |
pobj |
trials,for |
R10597 |
T15851 |
T15850 |
nummod |
600,trials |
R10598 |
T15852 |
T15822 |
punct |
.,trained |
R10599 |
T15854 |
T15855 |
prep |
In,ensured |
R10600 |
T15856 |
T15857 |
det |
all,experiments |
R10601 |
T15857 |
T15854 |
pobj |
experiments,In |
R10602 |
T15858 |
T15855 |
punct |
", ",ensured |
R10603 |
T15859 |
T15855 |
nsubjpass |
counterbalancing,ensured |
R10604 |
T15860 |
T15859 |
prep |
between,counterbalancing |
R10605 |
T15861 |
T15862 |
det |
both,odors |
R10606 |
T15862 |
T15860 |
pobj |
odors,between |
R10607 |
T15863 |
T15862 |
cc |
and,odors |
R10608 |
T15864 |
T15862 |
conj |
setups,odors |
R10609 |
T15865 |
T15855 |
auxpass |
was,ensured |
R10610 |
T15866 |
T15855 |
prep |
within,ensured |
R10611 |
T15867 |
T15866 |
cc |
and,within |
R10612 |
T15868 |
T15866 |
conj |
between,within |
R10613 |
T15869 |
T15870 |
amod |
genetic,groups |
R10614 |
T15870 |
T15868 |
pobj |
groups,between |
R10615 |
T15871 |
T15855 |
punct |
", ",ensured |
R10616 |
T15872 |
T15855 |
cc |
or,ensured |
R10617 |
T15873 |
T15874 |
nsubjpass |
results,compared |
R10618 |
T15874 |
T15855 |
conj |
compared,ensured |
R10619 |
T15875 |
T15874 |
auxpass |
were,compared |
R10620 |
T15876 |
T15874 |
prep |
with,compared |
R10621 |
T15877 |
T15878 |
amod |
counterbalanced,subgroups |
R10622 |
T15878 |
T15876 |
pobj |
subgroups,with |
R10623 |
T15879 |
T15874 |
punct |
", ",compared |
R10624 |
T15880 |
T15881 |
dep |
which,yielded |
R10625 |
T15881 |
T15874 |
advcl |
yielded,compared |
R10626 |
T15882 |
T15881 |
prep |
in,yielded |
R10627 |
T15883 |
T15884 |
det |
every,case |
R10628 |
T15884 |
T15882 |
pobj |
case,in |
R10629 |
T15885 |
T15886 |
amod |
identical,results |
R10630 |
T15886 |
T15881 |
dobj |
results,yielded |
R10631 |
T15887 |
T15855 |
punct |
.,ensured |
R10632 |
T15889 |
T15890 |
prep |
During,was |
R10633 |
T15891 |
T15892 |
det |
the,course |
R10634 |
T15892 |
T15889 |
pobj |
course,During |
R10635 |
T15893 |
T15892 |
amod |
entire,course |
R10636 |
T15894 |
T15892 |
prep |
of,course |
R10637 |
T15895 |
T15896 |
det |
the,experiment |
R10638 |
T15896 |
T15894 |
pobj |
experiment,of |
R10639 |
T15897 |
T15890 |
punct |
", ",was |
R10640 |
T15898 |
T15899 |
det |
the,person |
R10641 |
T15899 |
T15890 |
nsubj |
person,was |
R10642 |
T15900 |
T15899 |
acl |
handling,person |
R10643 |
T15901 |
T15902 |
det |
the,animals |
R10644 |
T15902 |
T15900 |
dobj |
animals,handling |
R10645 |
T15903 |
T15900 |
cc |
and,handling |
R10646 |
T15904 |
T15900 |
conj |
operating,handling |
R10647 |
T15905 |
T15906 |
det |
the,olfactometers |
R10648 |
T15906 |
T15904 |
dobj |
olfactometers,operating |
R10649 |
T15907 |
T15890 |
acomp |
blind,was |
R10650 |
T15908 |
T15907 |
prep |
to,blind |
R10651 |
T15909 |
T15910 |
det |
the,genotype |
R10652 |
T15910 |
T15908 |
pobj |
genotype,to |
R10653 |
T15911 |
T15910 |
prep |
of,genotype |
R10654 |
T15912 |
T15913 |
det |
the,mice |
R10655 |
T15913 |
T15911 |
pobj |
mice,of |
R10656 |
T15914 |
T15890 |
punct |
.,was |
R10657 |
T15964 |
T15965 |
compound |
Memory,measurement |
R10658 |
T15967 |
T15968 |
aux |
To,assess |
R10659 |
T15968 |
T15969 |
advcl |
assess,interleaved |
R10660 |
T15969 |
T15989 |
ccomp |
interleaved,included |
R10661 |
T15970 |
T15968 |
dobj |
memory,assess |
R10662 |
T15971 |
T15969 |
punct |
", ",interleaved |
R10663 |
T15972 |
T15969 |
prep |
after,interleaved |
R10664 |
T15973 |
T15974 |
nummod |
280,trials |
R10665 |
T15974 |
T15972 |
pobj |
trials,after |
R10666 |
T15975 |
T15974 |
prep |
of,trials |
R10667 |
T15976 |
T15975 |
pobj |
training,of |
R10668 |
T15977 |
T15978 |
aux |
to,discriminate |
R10669 |
T15978 |
T15976 |
acl |
discriminate,training |
R10670 |
T15979 |
T15978 |
prep |
between,discriminate |
R10671 |
T15980 |
T15981 |
amod |
pelargonic,acid |
R10672 |
T15981 |
T15979 |
pobj |
acid,between |
R10673 |
T15982 |
T15981 |
cc |
and,acid |
R10674 |
T15983 |
T15984 |
amod |
valeric,acid |
R10675 |
T15984 |
T15981 |
conj |
acid,acid |
R10676 |
T15985 |
T15969 |
punct |
", ",interleaved |
R10677 |
T15986 |
T15987 |
compound |
memory,trials |
R10678 |
T15987 |
T15969 |
nsubjpass |
trials,interleaved |
R10679 |
T15988 |
T15969 |
auxpass |
were,interleaved |
R10680 |
T15990 |
T15969 |
prep |
for,interleaved |
R10681 |
T15991 |
T15992 |
nummod |
120,trials |
R10682 |
T15992 |
T15990 |
pobj |
trials,for |
R10683 |
T15993 |
T15989 |
punct |
;,included |
R10684 |
T15994 |
T15995 |
advmod |
that,is |
R10685 |
T15995 |
T15989 |
advmod |
is,included |
R10686 |
T15996 |
T15989 |
punct |
", ",included |
R10687 |
T15997 |
T15989 |
prep |
within,included |
R10688 |
T15998 |
T15999 |
det |
each,block |
R10689 |
T15999 |
T15997 |
pobj |
block,within |
R10690 |
T16000 |
T15999 |
prep |
of,block |
R10691 |
T16001 |
T16002 |
nummod |
20,trials |
R10692 |
T16002 |
T16000 |
pobj |
trials,of |
R10693 |
T16003 |
T16004 |
nummod |
two,amylacetate |
R10694 |
T16004 |
T15989 |
nsubjpass |
amylacetate,included |
R10695 |
T16005 |
T16004 |
amod |
unrewarded,amylacetate |
R10696 |
T16006 |
T16004 |
cc |
and,amylacetate |
R10697 |
T16007 |
T16008 |
nummod |
two,ethylbutyrate |
R10698 |
T16008 |
T16010 |
compound |
ethylbutyrate,trials |
R10699 |
T16009 |
T16008 |
amod |
unrewarded,ethylbutyrate |
R10700 |
T16010 |
T16004 |
conj |
trials,amylacetate |
R10701 |
T16011 |
T15989 |
auxpass |
were,included |
R10702 |
T16012 |
T15989 |
punct |
.,included |
R10703 |
T16014 |
T16015 |
compound |
Memory,scores |
R10704 |
T16015 |
T16016 |
nsubjpass |
scores,given |
R10705 |
T16017 |
T16016 |
auxpass |
are,given |
R10706 |
T16018 |
T16016 |
prep |
as,given |
R10707 |
T16019 |
T16020 |
det |
the,fraction |
R10708 |
T16020 |
T16018 |
pobj |
fraction,as |
R10709 |
T16021 |
T16020 |
prep |
of,fraction |
R10710 |
T16022 |
T16023 |
det |
those,trials |
R10711 |
T16023 |
T16021 |
pobj |
trials,of |
R10712 |
T16024 |
T16023 |
amod |
unrewarded,trials |
R10713 |
T16025 |
T16026 |
dep |
that,responded |
R10714 |
T16026 |
T16023 |
relcl |
responded,trials |
R10715 |
T16027 |
T16026 |
auxpass |
were,responded |
R10716 |
T16028 |
T16026 |
prep |
to,responded |
R10717 |
T16029 |
T16026 |
punct |
“,responded |
R10718 |
T16030 |
T16026 |
advmod |
correctly,responded |
R10719 |
T16031 |
T16026 |
punct |
”,responded |
R10720 |
T16032 |
T16033 |
punct |
(,response |
R10721 |
T16033 |
T16026 |
parataxis |
response,responded |
R10722 |
T16034 |
T16035 |
compound |
licking,response |
R10723 |
T16035 |
T16033 |
dep |
response,response |
R10724 |
T16036 |
T16035 |
prep |
to,response |
R10725 |
T16037 |
T16038 |
det |
the,odor |
R10726 |
T16038 |
T16036 |
pobj |
odor,to |
R10727 |
T16039 |
T16040 |
dep |
that,rewarded |
R10728 |
T16040 |
T16038 |
relcl |
rewarded,odor |
R10729 |
T16041 |
T16040 |
auxpass |
was,rewarded |
R10730 |
T16042 |
T16040 |
prep |
in,rewarded |
R10731 |
T16043 |
T16044 |
det |
the,session |
R10732 |
T16044 |
T16042 |
pobj |
session,in |
R10733 |
T16045 |
T16044 |
amod |
initial,session |
R10734 |
T16046 |
T16044 |
compound |
training,session |
R10735 |
T16047 |
T16048 |
punct |
[,S |
R10736 |
T16048 |
T16035 |
parataxis |
S,response |
R10737 |
T16049 |
T16048 |
punct |
+,S |
R10738 |
T16050 |
T16048 |
punct |
],S |
R10739 |
T16051 |
T16033 |
punct |
", ",response |
R10740 |
T16052 |
T16033 |
det |
no,response |
R10741 |
T16053 |
T16033 |
prep |
to,response |
R10742 |
T16054 |
T16055 |
det |
the,odor |
R10743 |
T16055 |
T16053 |
pobj |
odor,to |
R10744 |
T16056 |
T16057 |
dep |
that,rewarded |
R10745 |
T16057 |
T16055 |
relcl |
rewarded,odor |
R10746 |
T16058 |
T16057 |
auxpass |
was,rewarded |
R10747 |
T16059 |
T16057 |
neg |
not,rewarded |
R10748 |
T16060 |
T16057 |
advmod |
initially,rewarded |
R10749 |
T16061 |
T16062 |
punct |
[,S |
R10750 |
T16062 |
T16033 |
parataxis |
S,response |
R10751 |
T16063 |
T16062 |
punct |
−,S |
R10752 |
T16064 |
T16062 |
punct |
],S |
R10753 |
T16065 |
T16033 |
punct |
),response |
R10754 |
T16066 |
T16016 |
punct |
.,given |
R10755 |
T16068 |
T16069 |
prep |
Due,trained |
R10756 |
T16070 |
T16068 |
pcomp |
to,Due |
R10757 |
T16071 |
T16072 |
det |
the,phenotype |
R10758 |
T16072 |
T16068 |
pobj |
phenotype,Due |
R10759 |
T16073 |
T16072 |
amod |
epileptic,phenotype |
R10760 |
T16074 |
T16072 |
cc |
and,phenotype |
R10761 |
T16075 |
T16076 |
det |
the,mortality |
R10762 |
T16076 |
T16072 |
conj |
mortality,phenotype |
R10763 |
T16077 |
T16078 |
advmod |
slightly,increased |
R10764 |
T16078 |
T16076 |
amod |
increased,mortality |
R10765 |
T16079 |
T16080 |
punct |
[,58 |
R10766 |
T16080 |
T16076 |
parataxis |
58,mortality |
R10767 |
T16081 |
T16080 |
punct |
],58 |
R10768 |
T16082 |
T16069 |
punct |
", ",trained |
R10769 |
T16083 |
T16084 |
nmod |
GluRBΔECS,FB |
R10770 |
T16084 |
T16086 |
compound |
FB,mice |
R10771 |
T16085 |
T16084 |
punct |
:,FB |
R10772 |
T16086 |
T16069 |
nsubjpass |
mice,trained |
R10773 |
T16087 |
T16069 |
auxpass |
were,trained |
R10774 |
T16088 |
T16089 |
advmod |
only,for |
R10775 |
T16089 |
T16069 |
prep |
for,trained |
R10776 |
T16090 |
T16091 |
det |
the,period |
R10777 |
T16091 |
T16089 |
pobj |
period,for |
R10778 |
T16092 |
T16091 |
amod |
initial,period |
R10779 |
T16093 |
T16091 |
prep |
of,period |
R10780 |
T16094 |
T16095 |
nummod |
400,trials |
R10781 |
T16095 |
T16093 |
pobj |
trials,of |
R10782 |
T16096 |
T16069 |
punct |
.,trained |
R10783 |
T16135 |
T16136 |
compound |
Learning,curves |
R10784 |
T16136 |
T16137 |
nsubjpass |
curves,analyzed |
R10785 |
T16138 |
T16136 |
prep |
for,curves |
R10786 |
T16139 |
T16140 |
preconj |
both,performance |
R10787 |
T16140 |
T16138 |
pobj |
performance,for |
R10788 |
T16141 |
T16140 |
amod |
correct,performance |
R10789 |
T16142 |
T16143 |
punct |
(,percentage |
R10790 |
T16143 |
T16140 |
parataxis |
percentage,performance |
R10791 |
T16144 |
T16143 |
punct |
“,percentage |
R10792 |
T16145 |
T16143 |
amod |
correct,percentage |
R10793 |
T16146 |
T16143 |
punct |
”,percentage |
R10794 |
T16147 |
T16143 |
punct |
),percentage |
R10795 |
T16148 |
T16140 |
cc |
and,performance |
R10796 |
T16149 |
T16150 |
det |
the,performance |
R10797 |
T16150 |
T16140 |
conj |
performance,performance |
R10798 |
T16151 |
T16150 |
compound |
discrimination,performance |
R10799 |
T16152 |
T16137 |
auxpass |
were,analyzed |
R10800 |
T16153 |
T16137 |
prep |
by,analyzed |
R10801 |
T16154 |
T16155 |
amod |
repeated,measure |
R10802 |
T16155 |
T16156 |
compound |
measure,ANOVA |
R10803 |
T16156 |
T16153 |
pobj |
ANOVA,by |
R10804 |
T16157 |
T16137 |
punct |
.,analyzed |
R10805 |
T16159 |
T16160 |
advmod |
Additionally,assessed |
R10806 |
T16161 |
T16160 |
punct |
", ",assessed |
R10807 |
T16162 |
T16163 |
compound |
learning,curves |
R10808 |
T16163 |
T16160 |
nsubjpass |
curves,assessed |
R10809 |
T16164 |
T16160 |
auxpass |
were,assessed |
R10810 |
T16165 |
T16160 |
prep |
by,assessed |
R10811 |
T16166 |
T16167 |
advmod |
linearly,fitting |
R10812 |
T16167 |
T16165 |
pobj |
fitting,by |
R10813 |
T16168 |
T16167 |
prep |
of,fitting |
R10814 |
T16169 |
T16170 |
compound |
trend,lines |
R10815 |
T16170 |
T16168 |
pobj |
lines,of |
R10816 |
T16171 |
T16167 |
prep |
to,fitting |
R10817 |
T16172 |
T16173 |
det |
the,data |
R10818 |
T16173 |
T16171 |
pobj |
data,to |
R10819 |
T16174 |
T16167 |
prep |
with,fitting |
R10820 |
T16175 |
T16176 |
amod |
fixed,offsets |
R10821 |
T16176 |
T16174 |
pobj |
offsets,with |
R10822 |
T16177 |
T16160 |
punct |
", ",assessed |
R10823 |
T16178 |
T16160 |
advcl |
leaving,assessed |
R10824 |
T16179 |
T16180 |
det |
the,slope |
R10825 |
T16180 |
T16178 |
dobj |
slope,leaving |
R10826 |
T16181 |
T16178 |
prep |
as,leaving |
R10827 |
T16182 |
T16183 |
det |
the,variable |
R10828 |
T16183 |
T16181 |
pobj |
variable,as |
R10829 |
T16184 |
T16183 |
amod |
only,variable |
R10830 |
T16185 |
T16160 |
punct |
.,assessed |
R10831 |
T16187 |
T16188 |
prep |
In,was |
R10832 |
T16189 |
T16187 |
amod |
general,In |
R10833 |
T16190 |
T16188 |
punct |
", ",was |
R10834 |
T16191 |
T16188 |
nsubj |
binning,was |
R10835 |
T16192 |
T16193 |
nummod |
100,trials |
R10836 |
T16193 |
T16188 |
attr |
trials,was |
R10837 |
T16194 |
T16193 |
prep |
per,trials |
R10838 |
T16195 |
T16194 |
pobj |
block,per |
R10839 |
T16196 |
T16188 |
punct |
.,was |
R10840 |
T16198 |
T16199 |
aux |
To,allow |
R10841 |
T16199 |
T16200 |
advcl |
allow,reduced |
R10842 |
T16201 |
T16199 |
prep |
for,allow |
R10843 |
T16202 |
T16203 |
det |
the,investigation |
R10844 |
T16203 |
T16201 |
pobj |
investigation,for |
R10845 |
T16204 |
T16203 |
prep |
of,investigation |
R10846 |
T16205 |
T16206 |
compound |
group,block |
R10847 |
T16206 |
T16208 |
compound |
block,interactions |
R10848 |
T16207 |
T16206 |
punct |
/,block |
R10849 |
T16208 |
T16204 |
pobj |
interactions,of |
R10850 |
T16209 |
T16200 |
punct |
", ",reduced |
R10851 |
T16210 |
T16211 |
det |
the,binning |
R10852 |
T16211 |
T16200 |
nsubjpass |
binning,reduced |
R10853 |
T16212 |
T16213 |
amod |
repeated,measure |
R10854 |
T16213 |
T16211 |
compound |
measure,binning |
R10855 |
T16214 |
T16211 |
compound |
ANOVA,binning |
R10856 |
T16215 |
T16200 |
auxpass |
was,reduced |
R10857 |
T16216 |
T16200 |
prep |
to,reduced |
R10858 |
T16217 |
T16218 |
nummod |
20,trials |
R10859 |
T16218 |
T16216 |
pobj |
trials,to |
R10860 |
T16219 |
T16218 |
prep |
per,trials |
R10861 |
T16220 |
T16219 |
pobj |
block,per |
R10862 |
T16221 |
T16200 |
punct |
.,reduced |
R10863 |
T16223 |
T16224 |
aux |
To,compare |
R10864 |
T16224 |
T16225 |
advcl |
compare,employed |
R10865 |
T16226 |
T16227 |
compound |
memory,performance |
R10866 |
T16227 |
T16224 |
dobj |
performance,compare |
R10867 |
T16228 |
T16224 |
prep |
in,compare |
R10868 |
T16229 |
T16230 |
det |
the,mice |
R10869 |
T16230 |
T16228 |
pobj |
mice,in |
R10870 |
T16231 |
T16232 |
nmod |
GluR,BRescue |
R10871 |
T16232 |
T16230 |
nmod |
BRescue,mice |
R10872 |
T16233 |
T16232 |
punct |
-,BRescue |
R10873 |
T16234 |
T16235 |
punct |
(,8 |
R10874 |
T16235 |
T16232 |
parataxis |
8,BRescue |
R10875 |
T16236 |
T16235 |
nsubj |
n,8 |
R10876 |
T16237 |
T16235 |
punct |
=,8 |
R10877 |
T16238 |
T16235 |
punct |
),8 |
R10878 |
T16239 |
T16232 |
cc |
and,BRescue |
R10879 |
T16240 |
T16241 |
compound |
GluR,BΔFB |
R10880 |
T16241 |
T16232 |
conj |
BΔFB,BRescue |
R10881 |
T16242 |
T16241 |
punct |
-,BΔFB |
R10882 |
T16243 |
T16244 |
punct |
(,22 |
R10883 |
T16244 |
T16241 |
parataxis |
22,BΔFB |
R10884 |
T16245 |
T16244 |
nsubj |
n,22 |
R10885 |
T16246 |
T16244 |
punct |
=,22 |
R10886 |
T16247 |
T16244 |
punct |
),22 |
R10887 |
T16248 |
T16225 |
punct |
", ",employed |
R10888 |
T16249 |
T16225 |
prep |
due,employed |
R10889 |
T16250 |
T16249 |
pcomp |
to,due |
R10890 |
T16251 |
T16252 |
det |
the,variability |
R10891 |
T16252 |
T16249 |
pobj |
variability,due |
R10892 |
T16253 |
T16252 |
amod |
high,variability |
R10893 |
T16254 |
T16225 |
punct |
", ",employed |
R10894 |
T16255 |
T16256 |
det |
a,approach |
R10895 |
T16256 |
T16225 |
nsubjpass |
approach,employed |
R10896 |
T16257 |
T16256 |
compound |
bootstrap,approach |
R10897 |
T16258 |
T16225 |
auxpass |
was,employed |
R10898 |
T16259 |
T16225 |
punct |
.,employed |
R10899 |
T16261 |
T16262 |
nsubjpass |
Subpopulations,selected |
R10900 |
T16263 |
T16261 |
prep |
of,Subpopulations |
R10901 |
T16264 |
T16265 |
nummod |
eight,animals |
R10902 |
T16265 |
T16263 |
pobj |
animals,of |
R10903 |
T16266 |
T16262 |
auxpass |
were,selected |
R10904 |
T16267 |
T16262 |
prep |
from,selected |
R10905 |
T16268 |
T16269 |
det |
the,population |
R10906 |
T16269 |
T16267 |
pobj |
population,from |
R10907 |
T16270 |
T16269 |
prep |
of,population |
R10908 |
T16271 |
T16272 |
nummod |
22,mice |
R10909 |
T16272 |
T16270 |
pobj |
mice,of |
R10910 |
T16273 |
T16274 |
compound |
GluR,BΔFB |
R10911 |
T16274 |
T16272 |
compound |
BΔFB,mice |
R10912 |
T16275 |
T16274 |
punct |
-,BΔFB |
R10913 |
T16276 |
T16262 |
punct |
", ",selected |
R10914 |
T16277 |
T16262 |
cc |
and,selected |
R10915 |
T16278 |
T16279 |
compound |
mean,memory |
R10916 |
T16279 |
T16280 |
nsubjpass |
memory,determined |
R10917 |
T16280 |
T16262 |
conj |
determined,selected |
R10918 |
T16281 |
T16280 |
auxpass |
was,determined |
R10919 |
T16282 |
T16280 |
punct |
.,determined |
R10920 |
T16284 |
T16285 |
prep |
In,exceeded |
R10921 |
T16286 |
T16287 |
amod |
only,"20,000" |
R10922 |
T16287 |
T16291 |
nummod |
"20,000",subpopulations |
R10923 |
T16288 |
T16287 |
quantmod |
343,"20,000" |
R10924 |
T16289 |
T16287 |
quantmod |
out,"20,000" |
R10925 |
T16290 |
T16287 |
quantmod |
of,"20,000" |
R10926 |
T16291 |
T16284 |
pobj |
subpopulations,In |
R10927 |
T16292 |
T16285 |
punct |
", ",exceeded |
R10928 |
T16293 |
T16294 |
compound |
mean,memory |
R10929 |
T16294 |
T16285 |
nsubj |
memory,exceeded |
R10930 |
T16295 |
T16296 |
det |
the,memory |
R10931 |
T16296 |
T16285 |
dobj |
memory,exceeded |
R10932 |
T16297 |
T16296 |
compound |
mean,memory |
R10933 |
T16298 |
T16299 |
compound |
GluR,BRescue |
R10934 |
T16299 |
T16296 |
compound |
BRescue,memory |
R10935 |
T16300 |
T16299 |
punct |
-,BRescue |
R10936 |
T16301 |
T16296 |
prep |
of,memory |
R10937 |
T16302 |
T16303 |
nummod |
74.99,% |
R10938 |
T16303 |
T16301 |
pobj |
%,of |
R10939 |
T16304 |
T16285 |
punct |
", ",exceeded |
R10940 |
T16305 |
T16285 |
advcl |
resulting,exceeded |
R10941 |
T16306 |
T16305 |
prep |
in,resulting |
R10942 |
T16307 |
T16308 |
det |
a,value |
R10943 |
T16308 |
T16306 |
pobj |
value,in |
R10944 |
T16309 |
T16308 |
compound |
p,value |
R10945 |
T16310 |
T16308 |
prep |
of,value |
R10946 |
T16311 |
T16312 |
nsubj |
p,"20,000" |
R10947 |
T16312 |
T16310 |
pcomp |
"20,000",of |
R10948 |
T16313 |
T16312 |
punct |
=,"20,000" |
R10949 |
T16314 |
T16312 |
nummod |
343,"20,000" |
R10950 |
T16315 |
T16312 |
punct |
/,"20,000" |
R10951 |
T16316 |
T16317 |
punct |
=,0.017 |
R10952 |
T16317 |
T16312 |
acl |
0.017,"20,000" |
R10953 |
T16318 |
T16285 |
punct |
.,exceeded |
R23 |
T99 |
T96 |
nmod |
hydroxy,isoxazolepropionate |
R27 |
T103 |
T96 |
nmod |
methyl,isoxazolepropionate |
R32 |
T108 |
T92 |
pobj |
receptors,of |
R1 |
T72 |
T73 |
amod |
Enhanced,Discrimination |
R2 |
T75 |
T73 |
compound |
Odor,Discrimination |
R3 |
T76 |
T73 |
cc |
and,Discrimination |
R4 |
T77 |
T78 |
amod |
Impaired,Memory |
R7 |
T80 |
T73 |
prep |
by,Discrimination |
R8 |
T81 |
T82 |
advmod |
Spatially,Controlled |
R9 |
T82 |
T83 |
amod |
Controlled,Switch |
R10 |
T83 |
T80 |
pobj |
Switch,by |
R11 |
T84 |
T83 |
prep |
of,Switch |
R12 |
T85 |
T86 |
compound |
AMPA,Receptors |
R13 |
T86 |
T84 |
pobj |
Receptors,of |
R14 |
T89 |
T90 |
amod |
Genetic,perturbations |
R15 |
T90 |
T91 |
nsubjpass |
perturbations,used |
R16 |
T92 |
T90 |
prep |
of,perturbations |
R17 |
T93 |
T94 |
nmod |
α,amino |
R33 |
T109 |
T108 |
punct |
(,receptors |
R34 |
T110 |
T108 |
appos |
AMPARs,receptors |
R35 |
T111 |
T91 |
punct |
),used |
R36 |
T112 |
T91 |
auxpass |
are,used |
R37 |
T113 |
T91 |
advmod |
widely,used |
R38 |
T114 |
T115 |
aux |
to,dissect |
R39 |
T115 |
T91 |
advcl |
dissect,used |
R40 |
T116 |
T117 |
amod |
molecular,mechanisms |
R41 |
T117 |
T115 |
dobj |
mechanisms,dissect |
R42 |
T118 |
T117 |
prep |
of,mechanisms |
R43 |
T119 |
T120 |
amod |
sensory,coding |
R44 |
T120 |
T118 |
pobj |
coding,of |
R45 |
T121 |
T120 |
punct |
", ",coding |
R46 |
T122 |
T120 |
conj |
learning,coding |
R47 |
T123 |
T122 |
punct |
", ",learning |
R48 |
T124 |
T122 |
cc |
and,learning |
R49 |
T125 |
T122 |
conj |
memory,learning |
R50 |
T126 |
T91 |
punct |
.,used |
R51 |
T128 |
T129 |
prep |
In,investigated |
R52 |
T130 |
T131 |
det |
this,study |
R53 |
T131 |
T128 |
pobj |
study,In |
R54 |
T132 |
T129 |
punct |
", ",investigated |
R55 |
T133 |
T129 |
nsubj |
we,investigated |
R56 |
T134 |
T135 |
det |
the,role |
R57 |
T135 |
T129 |
dobj |
role,investigated |
R58 |
T136 |
T135 |
prep |
of,role |
R59 |
T137 |
T138 |
npadvmod |
Ca2,permeable |
R63 |
T141 |
T136 |
pobj |
AMPARs,of |
R64 |
T142 |
T135 |
prep |
in,role |
R65 |
T143 |
T144 |
amod |
olfactory,behavior |
R66 |
T144 |
T142 |
pobj |
behavior,in |
R67 |
T145 |
T129 |
punct |
.,investigated |
R68 |
T147 |
T148 |
compound |
AMPAR,modification |
R69 |
T148 |
T149 |
nsubjpass |
modification,obtained |
R70 |
T150 |
T149 |
auxpass |
was,obtained |
R71 |
T151 |
T149 |
prep |
by,obtained |
R72 |
T152 |
T151 |
pobj |
depletion,by |
R73 |
T153 |
T152 |
prep |
of,depletion |
R74 |
T154 |
T155 |
det |
the,subunit |
R77 |
T157 |
T155 |
compound |
B,subunit |
R79 |
T159 |
T152 |
cc |
or,depletion |
R80 |
T160 |
T152 |
conj |
expression,depletion |
R81 |
T161 |
T160 |
prep |
of,expression |
R82 |
T162 |
T163 |
amod |
unedited,Q |
R88 |
T168 |
T163 |
punct |
),Q |
R89 |
T169 |
T149 |
punct |
", ",obtained |
R90 |
T170 |
T171 |
nsubj |
both,leading |
R91 |
T171 |
T149 |
advcl |
leading,obtained |
R92 |
T172 |
T171 |
prep |
to,leading |
R93 |
T173 |
T174 |
amod |
increased,permeability |
R97 |
T177 |
T174 |
prep |
of,permeability |
R98 |
T178 |
T177 |
pobj |
AMPARs,of |
R99 |
T179 |
T149 |
punct |
.,obtained |
R100 |
T181 |
T182 |
nsubj |
Mice,showed |
R101 |
T183 |
T181 |
prep |
with,Mice |
R102 |
T184 |
T185 |
det |
this,switch |
R60 |
T138 |
T141 |
amod |
permeable,AMPARs |
R106 |
T188 |
T185 |
punct |
", ",switch |
R107 |
T189 |
T190 |
advmod |
specifically,in |
R108 |
T190 |
T185 |
prep |
in,switch |
R109 |
T191 |
T190 |
pobj |
forebrain,in |
R110 |
T192 |
T182 |
punct |
", ",showed |
R111 |
T193 |
T194 |
amod |
enhanced,discrimination |
R114 |
T196 |
T194 |
cc |
and,discrimination |
R115 |
T197 |
T198 |
advmod |
more,rapid |
R116 |
T198 |
T199 |
amod |
rapid,learning |
R117 |
T199 |
T194 |
conj |
learning,discrimination |
R118 |
T200 |
T182 |
prep |
in,showed |
R119 |
T201 |
T202 |
det |
a,task |
R124 |
T206 |
T203 |
appos |
go,go |
R128 |
T210 |
T182 |
punct |
.,showed |
R129 |
T212 |
T213 |
amod |
Olfactory,memory |
R130 |
T213 |
T214 |
nsubjpass |
memory,impaired |
R131 |
T215 |
T214 |
punct |
", ",impaired |
R132 |
T216 |
T214 |
advmod |
however,impaired |
R133 |
T217 |
T214 |
punct |
", ",impaired |
R134 |
T218 |
T214 |
auxpass |
was,impaired |
R135 |
T219 |
T214 |
advmod |
dramatically,impaired |
R136 |
T220 |
T214 |
punct |
.,impaired |
R137 |
T222 |
T223 |
compound |
GluR,B |
R140 |
T225 |
T226 |
nsubj |
depletion,was |
R141 |
T227 |
T225 |
prep |
in,depletion |
R142 |
T228 |
T227 |
pobj |
forebrain,in |
R143 |
T229 |
T230 |
advmod |
ectopically,variable |
R144 |
T230 |
T226 |
acomp |
variable,was |
R145 |
T231 |
T232 |
punct |
(,mosaic |
R148 |
T234 |
T232 |
punct |
”,mosaic |
R149 |
T235 |
T232 |
punct |
),mosaic |
R150 |
T236 |
T230 |
prep |
among,variable |
R151 |
T237 |
T236 |
pobj |
individuals,among |
R152 |
T238 |
T230 |
cc |
and,variable |
R153 |
T239 |
T240 |
advmod |
strongly,correlated |
R154 |
T240 |
T230 |
conj |
correlated,variable |
R155 |
T241 |
T240 |
prep |
with,correlated |
R156 |
T242 |
T243 |
amod |
decreased,memory |
R159 |
T245 |
T243 |
prep |
in,memory |
R160 |
T246 |
T245 |
pobj |
hippocampus,in |
R161 |
T247 |
T246 |
cc |
and,hippocampus |
R162 |
T248 |
T246 |
conj |
cortex,hippocampus |
R163 |
T249 |
T226 |
punct |
.,was |
R164 |
T251 |
T252 |
advmod |
Accordingly,rescued |
R165 |
T253 |
T252 |
punct |
", ",rescued |
R166 |
T254 |
T252 |
nsubjpass |
memory,rescued |
R167 |
T255 |
T252 |
auxpass |
was,rescued |
R168 |
T256 |
T252 |
agent |
by,rescued |
R169 |
T257 |
T258 |
amod |
transgenic,expression |
R172 |
T260 |
T258 |
compound |
B,expression |
R174 |
T262 |
T258 |
acl |
restricted,expression |
R175 |
T263 |
T262 |
prep |
to,restricted |
R176 |
T264 |
T265 |
amod |
piriform,cortex |
R177 |
T265 |
T263 |
pobj |
cortex,to |
R178 |
T266 |
T265 |
cc |
and,cortex |
R179 |
T267 |
T265 |
conj |
hippocampus,cortex |
R180 |
T268 |
T252 |
punct |
", ",rescued |
R181 |
T269 |
T270 |
mark |
while,was |
R184 |
T272 |
T270 |
nsubj |
discrimination,was |
R186 |
T274 |
T270 |
acomp |
independent,was |
R187 |
T275 |
T274 |
prep |
of,independent |
R188 |
T276 |
T277 |
preconj |
both,variability |
R191 |
T279 |
T277 |
compound |
B,variability |
R193 |
T281 |
T277 |
cc |
and,variability |
R194 |
T282 |
T283 |
amod |
transgenic,expression |
R197 |
T285 |
T283 |
compound |
B,expression |
R199 |
T287 |
T252 |
punct |
.,rescued |
R200 |
T289 |
T290 |
advmod |
Thus,allowed |
R201 |
T291 |
T290 |
punct |
", ",allowed |
R202 |
T292 |
T293 |
amod |
correlated,differences |
R203 |
T293 |
T290 |
nsubj |
differences,allowed |
R204 |
T294 |
T293 |
prep |
in,differences |
R205 |
T295 |
T294 |
pobj |
behavior,in |
R206 |
T296 |
T295 |
cc |
and,behavior |
R207 |
T297 |
T295 |
conj |
levels,behavior |
R208 |
T298 |
T297 |
prep |
of,levels |
R209 |
T299 |
T300 |
compound |
GluR,B |
R212 |
T302 |
T298 |
pobj |
expression,of |
R213 |
T303 |
T304 |
det |
a,dissection |
R218 |
T308 |
T304 |
prep |
of,dissection |
R219 |
T309 |
T310 |
amod |
olfactory,learning |
R220 |
T310 |
T311 |
nmod |
learning,capabilities |
R227 |
T317 |
T290 |
punct |
.,allowed |
R4099 |
T6174 |
T6161 |
parataxis |
%,in |
R3769 |
T5585 |
T5583 |
ccomp |
varied,observed |
R1549 |
T2529 |
T2527 |
pobj |
gene,by |
R1581 |
T2563 |
T2560 |
dobj |
allele,unsilence |
R1630 |
T2614 |
T2605 |
dobj |
gene,removes |
R1639 |
T2623 |
T2621 |
pobj |
allele,to |
R1861 |
T2857 |
T2836 |
parataxis |
%,acquired |
R1979 |
T2983 |
T2981 |
pobj |
trial,during |
R2207 |
T3611 |
T3609 |
pobj |
form,in |
R3001 |
T4440 |
T4437 |
ccomp |
29.5,4 |
R3125 |
T4563 |
T4547 |
parataxis |
0.1,was |
R3298 |
T4745 |
T4740 |
pobj |
mice,in |
R266 |
T695 |
T692 |
nsubj |
analyses,are |
R305 |
T735 |
T733 |
parataxis |
9,hippocampus |
R322 |
T753 |
T750 |
nsubjpass |
correlates,delineated |
R374 |
T809 |
T807 |
pobj |
correlate,for |
R382 |
T817 |
T815 |
attr |
connections,be |
R386 |
T821 |
T819 |
pobj |
cortex,in |
R391 |
T826 |
T823 |
pobj |
connectivity,due |
R429 |
T866 |
T864 |
pobj |
circuitry,to |
R433 |
T870 |
T868 |
pobj |
bulb,of |
R452 |
T890 |
T892 |
nsubjpass |
circuits,postulated |
R505 |
T945 |
T947 |
nsubj |
enhancement,rest |
R513 |
T954 |
T952 |
pobj |
properties,on |
R524 |
T965 |
T961 |
parataxis |
cells,neurons |
R526 |
T967 |
T961 |
cc |
and,neurons |
R527 |
T968 |
T969 |
amod |
local,neurons |
R530 |
T971 |
T972 |
punct |
(,cells |
R533 |
T974 |
T972 |
punct |
),cells |
R534 |
T975 |
T961 |
prep |
of,neurons |
R535 |
T976 |
T977 |
det |
the,bulb |
R538 |
T979 |
T947 |
punct |
.,rest |
R539 |
T981 |
T982 |
prep |
In,controlled |
R540 |
T983 |
T984 |
det |
these,synapses |
R543 |
T986 |
T982 |
punct |
", ",controlled |
R544 |
T987 |
T988 |
amod |
lateral,inhibition |
R548 |
T991 |
T988 |
acl |
mediated,inhibition |
R549 |
T992 |
T991 |
agent |
by,mediated |
R550 |
T993 |
T994 |
det |
the,system |
R553 |
T996 |
T994 |
amod |
aminobutyric,system |
R556 |
T999 |
T994 |
compound |
A,system |
R558 |
T1001 |
T982 |
aux |
may,controlled |
R559 |
T1002 |
T982 |
auxpass |
be,controlled |
R560 |
T1003 |
T982 |
agent |
by,controlled |
R561 |
T1004 |
T1005 |
det |
the,activity |
R562 |
T1005 |
T1003 |
pobj |
activity,by |
R563 |
T1006 |
T1005 |
prep |
of,activity |
R564 |
T1007 |
T1008 |
det |
the,part |
R569 |
T1012 |
T982 |
punct |
", ",controlled |
R570 |
T1013 |
T1014 |
advmod |
perhaps,triggering |
R571 |
T1014 |
T982 |
advcl |
triggering,controlled |
R572 |
T1015 |
T1016 |
amod |
increased,release |
R575 |
T1018 |
T1020 |
amod |
aminobutyric,acid |
R578 |
T1021 |
T1016 |
prep |
by,release |
R579 |
T1022 |
T1023 |
nmod |
Ca2,influx |
R582 |
T1025 |
T1023 |
prep |
through,influx |
R583 |
T1026 |
T1027 |
npadvmod |
glutamate,gated |
R588 |
T1031 |
T1032 |
punct |
(,38 |
R591 |
T1034 |
T1032 |
punct |
],38 |
R592 |
T1035 |
T1032 |
punct |
;,38 |
R593 |
T1036 |
T1032 |
advcl |
see,38 |
R594 |
T1037 |
T1036 |
advmod |
also,see |
R595 |
T1038 |
T1036 |
punct |
[,see |
R596 |
T1039 |
T1036 |
dobj |
39,see |
R597 |
T1040 |
T1032 |
punct |
],38 |
R598 |
T1041 |
T1032 |
punct |
),38 |
R599 |
T1042 |
T982 |
punct |
.,controlled |
R600 |
T1044 |
T1045 |
prep |
Given,sought |
R601 |
T1046 |
T1047 |
mark |
that,rely |
R610 |
T1055 |
T1052 |
cc |
as,discrimination |
R615 |
T1060 |
T1047 |
prep |
on,rely |
R616 |
T1061 |
T1060 |
pobj |
properties,on |
R617 |
T1062 |
T1061 |
prep |
of,properties |
R618 |
T1063 |
T1064 |
amod |
fast,neurotransmission |
R621 |
T1066 |
T1064 |
acl |
mediated,neurotransmission |
R622 |
T1067 |
T1066 |
agent |
by,mediated |
R623 |
T1068 |
T1069 |
nmod |
α,amino |
R629 |
T1074 |
T1071 |
nmod |
hydroxy,isoxazolepropionate |
R633 |
T1078 |
T1071 |
nmod |
methyl,isoxazolepropionate |
R638 |
T1083 |
T1067 |
pobj |
receptors,by |
R639 |
T1084 |
T1083 |
punct |
(,receptors |
R640 |
T1085 |
T1083 |
appos |
AMPARs,receptors |
R641 |
T1086 |
T1045 |
punct |
),sought |
R642 |
T1087 |
T1045 |
punct |
", ",sought |
R643 |
T1088 |
T1045 |
nsubj |
we,sought |
R644 |
T1089 |
T1090 |
aux |
to,alter |
R645 |
T1090 |
T1045 |
xcomp |
alter,sought |
R646 |
T1091 |
T1090 |
punct |
", ",alter |
R647 |
T1092 |
T1090 |
prep |
by,alter |
R648 |
T1093 |
T1094 |
amod |
genetic,means |
R649 |
T1094 |
T1092 |
pobj |
means,by |
R650 |
T1095 |
T1090 |
punct |
", ",alter |
R651 |
T1096 |
T1097 |
det |
the,contribution |
R655 |
T1100 |
T1097 |
prep |
of,contribution |
R656 |
T1101 |
T1102 |
nmod |
α,amino |
R662 |
T1107 |
T1104 |
nmod |
hydroxy,isoxazolepropionate |
R666 |
T1111 |
T1104 |
nmod |
methyl,isoxazolepropionate |
R675 |
T1120 |
T1116 |
acl |
containing,channels |
R676 |
T1121 |
T1122 |
det |
the,subunit |
R679 |
T1124 |
T1125 |
compound |
GluR,B |
R682 |
T1127 |
T1045 |
punct |
.,sought |
R683 |
T1129 |
T1130 |
prep |
Of,contained |
R684 |
T1131 |
T1132 |
det |
the,constituents |
R688 |
T1135 |
T1132 |
punct |
", ",constituents |
R689 |
T1136 |
T1137 |
compound |
GluR,A |
R692 |
T1139 |
T1137 |
prep |
to,A |
R693 |
T1140 |
T1139 |
pobj |
D,to |
R694 |
T1141 |
T1137 |
punct |
(,A |
R695 |
T1142 |
T1137 |
appos |
GluR1,A |
R696 |
T1143 |
T1142 |
prep |
to,GluR1 |
R697 |
T1144 |
T1143 |
pobj |
4,to |
R698 |
T1145 |
T1137 |
punct |
),A |
R699 |
T1146 |
T1137 |
punct |
", ",A |
R700 |
T1147 |
T1148 |
dep |
which,form |
R701 |
T1148 |
T1137 |
relcl |
form,A |
R706 |
T1154 |
T1153 |
amod |
binary,combinations |
R707 |
T1155 |
T1153 |
compound |
subunit,combinations |
R711 |
T1159 |
T1158 |
punct |
-,B |
R720 |
T1168 |
T1169 |
compound |
GluR,B |
R736 |
T1186 |
T1185 |
compound |
ion,conductance |
R747 |
T1197 |
T1198 |
advmod |
Notably,mediated |
R748 |
T1199 |
T1198 |
punct |
", ",mediated |
R751 |
T1203 |
T1201 |
amod |
low,permeability |
R752 |
T1204 |
T1201 |
nmod |
Ca2,permeability |
R758 |
T1210 |
T1201 |
prep |
in,permeability |
R796 |
T1248 |
T1246 |
pobj |
M2,of |
R802 |
T1254 |
T1236 |
parataxis |
48,site |
R988 |
T1448 |
T1451 |
amod |
permeable,AMPARs |
R1034 |
T1499 |
T1496 |
pobj |
switch,Concerning |
R1127 |
T1595 |
T1598 |
amod |
restricted,systems |
R1175 |
T1643 |
T1584 |
parataxis |
57,overcome |
R1186 |
T1656 |
T1658 |
nmod |
R,B |
R1205 |
T1675 |
T1672 |
amod |
prone,phenotype |
R1246 |
T1720 |
T1718 |
pobj |
separation,for |
R1256 |
T1730 |
T1717 |
nsubj |
we,exploited |
R1257 |
T1731 |
T1732 |
det |
a,phenomenon |
R1260 |
T1734 |
T1732 |
amod |
known,phenomenon |
R1261 |
T1732 |
T1717 |
dobj |
phenomenon,exploited |
R1262 |
T1736 |
T1732 |
prep |
of,phenomenon |
R1264 |
T1738 |
T1732 |
punct |
", ",phenomenon |
R1265 |
T1739 |
T1740 |
dep |
which,concerns |
R1267 |
T1741 |
T1742 |
amod |
heterogeneous,expression |
R1269 |
T1743 |
T1742 |
prep |
among,expression |
R1273 |
T1747 |
T1743 |
cc |
and,among |
R1275 |
T1749 |
T1743 |
conj |
among,among |
R1276 |
T1750 |
T1751 |
advmod |
genetically,identical |
R1278 |
T1752 |
T1749 |
pobj |
individuals,among |
R1279 |
T1753 |
T1752 |
prep |
of,individuals |
R1280 |
T1754 |
T1755 |
det |
a,line |
R1283 |
T1757 |
T1717 |
punct |
.,exploited |
R1284 |
T1759 |
T1760 |
mark |
Although,is |
R1291 |
T1767 |
T1760 |
advmod |
usually,is |
R1292 |
T1768 |
T1760 |
acomp |
undesired,is |
R1294 |
T1770 |
T1766 |
advmod |
here,took |
R1295 |
T1771 |
T1766 |
nsubj |
we,took |
R1297 |
T1773 |
T1772 |
prep |
of,advantage |
R1298 |
T1774 |
T1773 |
pobj |
it,of |
R1300 |
T1776 |
T1775 |
pcomp |
ablating,by |
R1305 |
T1781 |
T1782 |
npadvmod |
gene,targeted |
R1312 |
T1788 |
T1784 |
compound |
B,alleles |
R1314 |
T1790 |
T1776 |
prep |
with,ablating |
R1315 |
T1791 |
T1792 |
det |
the,help |
R1317 |
T1793 |
T1792 |
prep |
of,help |
R1318 |
T1794 |
T1795 |
det |
a,line |
R1321 |
T1795 |
T1793 |
pobj |
line,of |
R1322 |
T1798 |
T1795 |
prep |
with,line |
R1327 |
T1803 |
T1802 |
pobj |
forebrain,in |
R1328 |
T1804 |
T1766 |
punct |
.,took |
R1334 |
T1812 |
T1808 |
dobj |
levels,correlating |
R1336 |
T1814 |
T1815 |
npadvmod |
olfaction,related |
R1341 |
T1819 |
T1808 |
prep |
with,correlating |
R1346 |
T1824 |
T1807 |
nsubj |
we,investigated |
R1347 |
T1825 |
T1826 |
det |
the,dependence |
R1348 |
T1826 |
T1807 |
dobj |
dependence,investigated |
R1350 |
T1828 |
T1829 |
compound |
GluR,B |
R1353 |
T1831 |
T1826 |
prep |
of,dependence |
R1354 |
T1832 |
T1833 |
amod |
olfactory,discrimination |
R1356 |
T1834 |
T1833 |
cc |
and,discrimination |
R1357 |
T1835 |
T1833 |
conj |
memory,discrimination |
R1359 |
T1838 |
T1839 |
advmod |
Moreover,used |
R1362 |
T1842 |
T1839 |
advcl |
delineate,used |
R1363 |
T1843 |
T1844 |
det |
the,areas |
R1367 |
T1847 |
T1846 |
prep |
in,involved |
R1368 |
T1848 |
T1849 |
det |
these,processes |
R1372 |
T1852 |
T1839 |
nsubj |
we,used |
R1379 |
T1859 |
T1858 |
punct |
-,B |
R1393 |
T1875 |
T1874 |
aux |
to,dissect |
R1407 |
T1889 |
T1888 |
punct |
-,mediated |
R1409 |
T1891 |
T1890 |
compound |
AMPAR,properties |
R1410 |
T1890 |
T1884 |
pobj |
properties,of |
R1380 |
T1860 |
T1856 |
pobj |
ablation,of |
R1381 |
T1861 |
T1854 |
punct |
", ",rescue |
R1382 |
T1858 |
T1860 |
compound |
B,ablation |
R1383 |
T1863 |
T1854 |
prep |
in,rescue |
R1384 |
T1864 |
T1865 |
amod |
piriform,cortex |
R1385 |
T1862 |
T1863 |
advmod |
specifically,in |
R1386 |
T1866 |
T1865 |
cc |
and,cortex |
R1387 |
T1865 |
T1863 |
pobj |
cortex,in |
R1388 |
T1868 |
T1839 |
punct |
.,used |
R1389 |
T1871 |
T1872 |
nsubj |
efforts,allowed |
R1390 |
T1867 |
T1865 |
conj |
hippocampus,cortex |
R1391 |
T1874 |
T1872 |
ccomp |
dissect,allowed |
R1392 |
T1870 |
T1871 |
det |
These,efforts |
R1394 |
T1873 |
T1874 |
nsubj |
us,dissect |
R1395 |
T1877 |
T1878 |
advmod |
both,spatially |
R1396 |
T1878 |
T1874 |
advmod |
spatially,dissect |
R1397 |
T1876 |
T1874 |
punct |
", ",dissect |
R1398 |
T1880 |
T1878 |
conj |
mechanistically,spatially |
R1399 |
T1881 |
T1874 |
punct |
", ",dissect |
R1400 |
T1879 |
T1878 |
cc |
and,spatially |
R1401 |
T1883 |
T1874 |
dobj |
role,dissect |
R1402 |
T1882 |
T1883 |
det |
the,role |
R1403 |
T1885 |
T1886 |
compound |
GluR,B |
R1404 |
T1886 |
T1888 |
npadvmod |
B,mediated |
R1405 |
T1884 |
T1883 |
prep |
of,role |
R1406 |
T1888 |
T1890 |
amod |
mediated,properties |
R1408 |
T1887 |
T1886 |
punct |
-,B |
R1411 |
T1893 |
T1894 |
amod |
selected,regions |
R1412 |
T1894 |
T1892 |
pobj |
regions,in |
R1413 |
T1892 |
T1883 |
prep |
in,role |
R1414 |
T1896 |
T1883 |
prep |
in,role |
R1415 |
T1897 |
T1898 |
compound |
odor,learning |
R1416 |
T1895 |
T1894 |
compound |
brain,regions |
R1417 |
T1899 |
T1898 |
punct |
", ",learning |
R1418 |
T1898 |
T1896 |
pobj |
learning,in |
R1419 |
T1901 |
T1900 |
punct |
", ",discrimination |
R1420 |
T1902 |
T1900 |
cc |
and,discrimination |