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PMC:1253828 / 5481-6873 JSONTXT

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Id Subject Object Predicate Lexical cue
T1770 0-4 NN denotes Mtf1
T1771 26-30 NNS denotes mice
T1772 5-16 JJ denotes conditional
T1773 17-25 NN denotes knockout
T1774 36-45 VBN denotes generated
T1775 31-35 VBD denotes were
T1776 46-48 IN denotes in
T1777 49-62 NN denotes collaboration
T1778 63-67 IN denotes with
T1779 68-70 NNP denotes Dr
T1780 79-86 NNP denotes Leviten
T1781 71-78 NNP denotes Michael
T1782 87-88 -LRB- denotes (
T1783 92-98 NNP denotes Carlos
T1784 88-91 NNP denotes San
T1785 98-100 , denotes ,
T1786 100-102 NNP denotes CA
T1787 102-103 -RRB- denotes )
T1788 103-104 . denotes .
T1789 104-253 sentence denotes Two genomic clones containing exons 3 to 6 of Mtf1 were used to construct a gene targeting vector for homologous recombination (Supplementary Data).
T1790 105-108 CD denotes Two
T1791 117-123 NNS denotes clones
T1792 109-116 JJ denotes genomic
T1793 161-165 VBN denotes used
T1794 124-134 VBG denotes containing
T1795 135-140 NNS denotes exons
T1796 141-142 CD denotes 3
T1797 143-145 IN denotes to
T1798 146-147 CD denotes 6
T1799 148-150 IN denotes of
T1800 151-155 NN denotes Mtf1
T1801 156-160 VBD denotes were
T1802 166-168 TO denotes to
T1803 169-178 VB denotes construct
T1804 179-180 DT denotes a
T1805 196-202 NN denotes vector
T1806 181-185 NN denotes gene
T1807 186-195 NN denotes targeting
T1808 203-206 IN denotes for
T1809 207-217 JJ denotes homologous
T1810 218-231 NN denotes recombination
T1811 232-233 -LRB- denotes (
T1812 247-251 NNS denotes Data
T1813 233-246 JJ denotes Supplementary
T1814 251-252 -RRB- denotes )
T1815 252-253 . denotes .
T1816 253-436 sentence denotes A neomycin resistance cassette (PGK-neo) flanked by two loxP sites was cloned into the SacI site 5′ of exon 3 of Mtf1, the third loxP site was cloned into the ScaI site 3′ of exon 4.
T1817 254-255 DT denotes A
T1818 276-284 NN denotes cassette
T1819 256-264 NN denotes neomycin
T1820 265-275 NN denotes resistance
T1821 325-331 VBN denotes cloned
T1822 285-286 -LRB- denotes (
T1823 286-289 NN denotes PGK
T1824 290-293 NN denotes neo
T1825 289-290 HYPH denotes -
T1826 293-294 -RRB- denotes )
T1827 295-302 VBN denotes flanked
T1828 303-305 IN denotes by
T1829 306-309 CD denotes two
T1830 315-320 NNS denotes sites
T1831 310-314 NN denotes loxP
T1832 321-324 VBD denotes was
T1833 397-403 VBN denotes cloned
T1834 332-336 IN denotes into
T1835 337-340 DT denotes the
T1836 346-350 NN denotes site
T1837 341-345 NN denotes SacI
T1838 351-352 CD denotes 5
T1839 352-353 SYM denotes ′
T1840 354-356 IN denotes of
T1841 357-361 NN denotes exon
T1842 362-363 CD denotes 3
T1843 364-366 IN denotes of
T1844 367-371 NN denotes Mtf1
T1845 371-373 , denotes ,
T1846 373-376 DT denotes the
T1847 388-392 NN denotes site
T1848 377-382 JJ denotes third
T1849 383-387 NN denotes loxP
T1850 393-396 VBD denotes was
T1851 404-408 IN denotes into
T1852 409-412 DT denotes the
T1853 418-422 NN denotes site
T1854 413-417 NN denotes ScaI
T1855 423-424 CD denotes 3
T1856 424-425 SYM denotes ′
T1857 426-428 IN denotes of
T1858 429-433 NN denotes exon
T1859 434-435 CD denotes 4
T1860 435-436 . denotes .
T1861 436-513 sentence denotes A thymidine kinase (TK) cassette was inserted in the HpaI site 3′ of exon 6.
T1862 437-438 DT denotes A
T1863 461-469 NN denotes cassette
T1864 439-448 NN denotes thymidine
T1865 449-455 NN denotes kinase
T1866 456-457 -LRB- denotes (
T1867 457-459 NN denotes TK
T1868 459-460 -RRB- denotes )
T1869 474-482 VBN denotes inserted
T1870 470-473 VBD denotes was
T1871 483-485 IN denotes in
T1872 486-489 DT denotes the
T1873 495-499 NN denotes site
T1874 490-494 NN denotes HpaI
T1875 500-501 CD denotes 3
T1876 501-502 SYM denotes ′
T1877 503-505 IN denotes of
T1878 506-510 NN denotes exon
T1879 511-512 CD denotes 6
T1880 512-513 . denotes .
T1881 513-706 sentence denotes 129 ES cells were electroporated with the linearized targeting vector, selected in the presence of G418 and FIAU, and screened for correct integration events by PCR and Southern blot analysis.
T1882 514-517 CD denotes 129
T1883 521-526 NNS denotes cells
T1884 518-520 NN denotes ES
T1885 532-546 VBN denotes electroporated
T1886 527-531 VBD denotes were
T1887 547-551 IN denotes with
T1888 552-555 DT denotes the
T1889 577-583 NN denotes vector
T1890 556-566 VBN denotes linearized
T1891 567-576 NN denotes targeting
T1892 583-585 , denotes ,
T1893 585-593 VBN denotes selected
T1894 594-596 IN denotes in
T1895 597-600 DT denotes the
T1896 601-609 NN denotes presence
T1897 610-612 IN denotes of
T1898 613-617 NN denotes G418
T1899 618-621 CC denotes and
T1900 622-626 NN denotes FIAU
T1901 626-628 , denotes ,
T1902 628-631 CC denotes and
T1903 632-640 VBN denotes screened
T1904 641-644 IN denotes for
T1905 645-652 JJ denotes correct
T1906 665-671 NNS denotes events
T1907 653-664 NN denotes integration
T1908 672-674 IN denotes by
T1909 675-678 NN denotes PCR
T1910 697-705 NN denotes analysis
T1911 679-682 CC denotes and
T1912 683-691 NNP denotes Southern
T1913 692-696 NN denotes blot
T1914 705-706 . denotes .
T1915 706-929 sentence denotes Transient expression of Cre recombinase led to removal of the PGK-neo cassette, and mice carrying the modified Mtf1loxP allele were generated by injection of positive clones into C57Bl/6 blastocysts and subsequent crosses.
T1916 707-716 JJ denotes Transient
T1917 717-727 NN denotes expression
T1918 747-750 VBD denotes led
T1919 728-730 IN denotes of
T1920 731-734 NN denotes Cre
T1921 735-746 NN denotes recombinase
T1922 751-753 IN denotes to
T1923 754-761 NN denotes removal
T1924 762-764 IN denotes of
T1925 765-768 DT denotes the
T1926 777-785 NN denotes cassette
T1927 769-772 NN denotes PGK
T1928 773-776 NN denotes neo
T1929 772-773 HYPH denotes -
T1930 785-787 , denotes ,
T1931 787-790 CC denotes and
T1932 791-795 NNS denotes mice
T1933 839-848 VBN denotes generated
T1934 796-804 VBG denotes carrying
T1935 805-808 DT denotes the
T1936 827-833 NN denotes allele
T1937 809-817 VBN denotes modified
T1938 818-826 NN denotes Mtf1loxP
T1939 834-838 VBD denotes were
T1940 849-851 IN denotes by
T1941 852-861 NN denotes injection
T1942 862-864 IN denotes of
T1943 865-873 JJ denotes positive
T1944 874-880 NNS denotes clones
T1945 881-885 IN denotes into
T1946 886-891 NN denotes C57Bl
T1947 894-905 NNS denotes blastocysts
T1948 891-892 HYPH denotes /
T1949 892-893 CD denotes 6
T1950 906-909 CC denotes and
T1951 910-920 JJ denotes subsequent
T1952 921-928 NNS denotes crosses
T1953 928-929 . denotes .
T1955 930-940 JJ denotes Homozygous
T1956 962-969 NNS denotes animals
T1957 941-952 JJ denotes conditional
T1958 953-961 NN denotes knockout
T1959 991-998 VBN denotes crossed
T1960 970-971 -LRB- denotes (
T1961 971-979 NN denotes Mtf1loxP
T1962 980-984 NN denotes loxP
T1963 979-980 HYPH denotes /
T1964 984-985 -RRB- denotes )
T1965 986-990 VBD denotes were
T1966 999-1003 IN denotes with
T1967 1004-1007 DT denotes the
T1968 1035-1039 NN denotes line
T2099 1137-1138 . denotes .
T2100 1138-1392 sentence denotes The mice were genotyped by PCR using the following primers (Microsynth): Cre recombinase: 5′-CTATCCAGCAACATTTGGGCCAGC-3′; 5′-CCAGGTTACGGATATAGTTCATGAC-3′, Mtf1loxP or wild-type allele: 5′-CACACCCAGTTTGTGTATGTCTTC-3′; 5′-CAGTCACAAGCAAATTACCAAACACTGCC-3′.
T2101 1139-1142 DT denotes The
T2102 1143-1147 NNS denotes mice
T2103 1153-1162 VBN denotes genotyped
T2104 1148-1152 VBD denotes were
T2105 1163-1165 IN denotes by
T2106 1166-1169 NN denotes PCR
T2107 1170-1175 VBG denotes using
T2108 1176-1179 DT denotes the
T2109 1190-1197 NNS denotes primers
T2110 1180-1189 VBG denotes following
T2111 1198-1199 -LRB- denotes (
T2112 1199-1209 NNP denotes Microsynth
T2113 1209-1210 -RRB- denotes )
T2114 1210-1212 : denotes :
T2115 1212-1215 NN denotes Cre
T2116 1216-1227 NN denotes recombinase
T2117 1264-1289 NN denotes CCAGGTTACGGATATAGTTCATGAC
T2118 1227-1229 : denotes :
T2119 1229-1230 CD denotes 5
T2120 1232-1256 NN denotes CTATCCAGCAACATTTGGGCCAGC
T2121 1230-1231 SYM denotes ′
T2122 1231-1232 HYPH denotes -
T2123 1256-1257 HYPH denotes -
T2124 1257-1258 CD denotes 3
T2125 1258-1259 SYM denotes ′
T2126 1259-1260 : denotes ;
T2127 1261-1262 CD denotes 5
T2128 1262-1263 SYM denotes ′
T2129 1263-1264 HYPH denotes -
T2130 1359-1388 NN denotes CAGTCACAAGCAAATTACCAAACACTGCC
T2131 1289-1290 HYPH denotes -
T2132 1290-1291 CD denotes 3
T2133 1291-1292 SYM denotes ′
T2134 1292-1294 , denotes ,
T2135 1294-1302 NN denotes Mtf1loxP
T2136 1303-1305 CC denotes or
T2137 1306-1310 JJ denotes wild
T2138 1311-1315 NN denotes type
T2139 1310-1311 HYPH denotes -
T2140 1316-1322 NN denotes allele
T2141 1322-1324 : denotes :
T2142 1324-1325 CD denotes 5
T2143 1327-1351 NN denotes CACACCCAGTTTGTGTATGTCTTC
T2144 1325-1326 SYM denotes ′
T2145 1326-1327 HYPH denotes -
T2146 1351-1352 HYPH denotes -
T2147 1352-1353 CD denotes 3
T2148 1353-1354 SYM denotes ′
T2149 1354-1355 : denotes ;
T2150 1356-1357 CD denotes 5
T2151 1357-1358 SYM denotes ′
T2152 1358-1359 HYPH denotes -
T2153 1388-1389 HYPH denotes -
T2154 1389-1390 CD denotes 3
T2155 1390-1391 SYM denotes ′
T2156 1391-1392 . denotes .
T1954 929-1138 sentence denotes Homozygous conditional knockout animals (Mtf1loxP/loxP) were crossed with the Cre recombinase transgenic line Mx-cre (a gift from Prof. Michel Aguet) to obtain an inducible, liver-specific Mtf1 knockout line.
T2075 1012-1023 NN denotes recombinase
T2076 1024-1034 JJ denotes transgenic
T2077 1040-1042 NN denotes Mx
T2078 1043-1046 NN denotes cre
T2079 1042-1043 HYPH denotes -
T2080 1047-1048 -LRB- denotes (
T2081 1050-1054 NN denotes gift
T2082 1048-1049 DT denotes a
T2083 1055-1059 IN denotes from
T2084 1060-1065 NNP denotes Prof.
T2085 1073-1078 NNP denotes Aguet
T2086 1066-1072 NNP denotes Michel
T2087 1078-1079 -RRB- denotes )
T2088 1080-1082 TO denotes to
T2089 1083-1089 VB denotes obtain
T2090 1090-1092 DT denotes an
T2091 1133-1137 NN denotes line
T2092 1093-1102 JJ denotes inducible
T2093 1102-1104 , denotes ,
T2094 1104-1109 NN denotes liver
T2095 1110-1118 JJ denotes specific
T2096 1109-1110 HYPH denotes -
T2097 1119-1123 NN denotes Mtf1
T2098 1124-1132 NN denotes knockout
T2074 1008-1011 NN denotes Cre
R1042 T1770 T1771 nmod Mtf1,mice
R1043 T1771 T1774 nsubjpass mice,generated
R1044 T1772 T1773 amod conditional,knockout
R1045 T1773 T1771 compound knockout,mice
R1046 T1775 T1774 auxpass were,generated
R1047 T1776 T1774 prep in,generated
R1048 T1777 T1776 pobj collaboration,in
R1049 T1778 T1777 prep with,collaboration
R1050 T1779 T1780 compound Dr,Leviten
R1051 T1780 T1778 pobj Leviten,with
R1052 T1781 T1780 compound Michael,Leviten
R1053 T1782 T1783 punct (,Carlos
R1054 T1783 T1780 parataxis Carlos,Leviten
R1055 T1784 T1783 compound San,Carlos
R1056 T1785 T1783 punct ", ",Carlos
R1057 T1786 T1783 npadvmod CA,Carlos
R1058 T1787 T1783 punct ),Carlos
R1059 T1788 T1774 punct .,generated
R1060 T1790 T1791 nummod Two,clones
R1061 T1791 T1793 nsubjpass clones,used
R1062 T1792 T1791 amod genomic,clones
R1063 T1794 T1791 acl containing,clones
R1064 T1795 T1796 nmod exons,3
R1065 T1796 T1794 dobj 3,containing
R1066 T1797 T1796 prep to,3
R1067 T1798 T1797 pobj 6,to
R1068 T1799 T1796 prep of,3
R1069 T1800 T1799 pobj Mtf1,of
R1070 T1801 T1793 auxpass were,used
R1071 T1802 T1803 aux to,construct
R1072 T1803 T1793 advcl construct,used
R1073 T1804 T1805 det a,vector
R1074 T1805 T1803 dobj vector,construct
R1075 T1806 T1807 compound gene,targeting
R1076 T1807 T1805 compound targeting,vector
R1077 T1808 T1803 prep for,construct
R1078 T1809 T1810 amod homologous,recombination
R1079 T1810 T1808 pobj recombination,for
R1080 T1811 T1812 punct (,Data
R1081 T1812 T1803 parataxis Data,construct
R1082 T1813 T1812 amod Supplementary,Data
R1083 T1814 T1812 punct ),Data
R1084 T1815 T1793 punct .,used
R1085 T1817 T1818 det A,cassette
R1086 T1818 T1821 nsubjpass cassette,cloned
R1087 T1819 T1818 compound neomycin,cassette
R1088 T1820 T1818 compound resistance,cassette
R1089 T1821 T1833 ccomp cloned,cloned
R1090 T1822 T1818 punct (,cassette
R1091 T1823 T1824 compound PGK,neo
R1092 T1824 T1818 appos neo,cassette
R1093 T1825 T1824 punct -,neo
R1094 T1826 T1818 punct ),cassette
R1095 T1827 T1818 acl flanked,cassette
R1096 T1828 T1827 agent by,flanked
R1097 T1829 T1830 nummod two,sites
R1098 T1830 T1828 pobj sites,by
R1099 T1831 T1830 compound loxP,sites
R1100 T1832 T1821 auxpass was,cloned
R1101 T1834 T1821 prep into,cloned
R1102 T1835 T1836 det the,site
R1103 T1836 T1834 pobj site,into
R1104 T1837 T1836 compound SacI,site
R1105 T1838 T1836 npadvmod 5,site
R1106 T1839 T1838 punct ′,5
R1107 T1840 T1838 prep of,5
R1108 T1841 T1840 pobj exon,of
R1109 T1842 T1841 nummod 3,exon
R1110 T1843 T1841 prep of,exon
R1111 T1844 T1843 pobj Mtf1,of
R1112 T1845 T1833 punct ", ",cloned
R1113 T1846 T1847 det the,site
R1114 T1847 T1833 nsubjpass site,cloned
R1115 T1848 T1847 amod third,site
R1116 T1849 T1847 compound loxP,site
R1117 T1850 T1833 auxpass was,cloned
R1118 T1851 T1833 prep into,cloned
R1119 T1852 T1853 det the,site
R1120 T1853 T1851 pobj site,into
R1121 T1854 T1853 compound ScaI,site
R1122 T1855 T1853 npadvmod 3,site
R1123 T1856 T1855 punct ′,3
R1124 T1857 T1855 prep of,3
R1125 T1858 T1857 pobj exon,of
R1126 T1859 T1858 nummod 4,exon
R1127 T1860 T1833 punct .,cloned
R1128 T1862 T1863 det A,cassette
R1129 T1863 T1869 nsubjpass cassette,inserted
R1130 T1864 T1865 nmod thymidine,kinase
R1131 T1865 T1863 nmod kinase,cassette
R1132 T1866 T1865 punct (,kinase
R1133 T1867 T1865 appos TK,kinase
R1134 T1868 T1863 punct ),cassette
R1135 T1870 T1869 auxpass was,inserted
R1136 T1871 T1869 prep in,inserted
R1137 T1872 T1873 det the,site
R1138 T1873 T1871 pobj site,in
R1139 T1874 T1873 compound HpaI,site
R1140 T1875 T1873 npadvmod 3,site
R1141 T1876 T1875 punct ′,3
R1142 T1877 T1875 prep of,3
R1143 T1878 T1877 pobj exon,of
R1144 T1879 T1878 nummod 6,exon
R1145 T1880 T1869 punct .,inserted
R1146 T1882 T1883 nummod 129,cells
R1147 T1883 T1885 nsubjpass cells,electroporated
R1148 T1884 T1883 compound ES,cells
R1149 T1886 T1885 auxpass were,electroporated
R1150 T1887 T1885 prep with,electroporated
R1151 T1888 T1889 det the,vector
R1152 T1889 T1887 pobj vector,with
R1153 T1890 T1889 amod linearized,vector
R1154 T1891 T1889 compound targeting,vector
R1155 T1892 T1889 punct ", ",vector
R1156 T1893 T1889 acl selected,vector
R1157 T1894 T1893 prep in,selected
R1158 T1895 T1896 det the,presence
R1159 T1896 T1894 pobj presence,in
R1160 T1897 T1896 prep of,presence
R1161 T1898 T1897 pobj G418,of
R1162 T1899 T1898 cc and,G418
R1163 T1900 T1898 conj FIAU,G418
R1164 T1901 T1885 punct ", ",electroporated
R1165 T1902 T1885 cc and,electroporated
R1166 T1903 T1885 conj screened,electroporated
R1167 T1904 T1903 prep for,screened
R1168 T1905 T1906 amod correct,events
R1169 T1906 T1904 pobj events,for
R1170 T1907 T1906 compound integration,events
R1171 T1908 T1903 prep by,screened
R1172 T1909 T1910 nmod PCR,analysis
R1173 T1910 T1908 pobj analysis,by
R1174 T1911 T1909 cc and,PCR
R1175 T1912 T1913 compound Southern,blot
R1176 T1913 T1909 conj blot,PCR
R1177 T1914 T1885 punct .,electroporated
R1178 T1916 T1917 amod Transient,expression
R1179 T1917 T1918 nsubj expression,led
R1180 T1919 T1917 prep of,expression
R1181 T1920 T1921 compound Cre,recombinase
R1182 T1921 T1919 pobj recombinase,of
R1183 T1922 T1918 prep to,led
R1184 T1923 T1922 pobj removal,to
R1185 T1924 T1923 prep of,removal
R1186 T1925 T1926 det the,cassette
R1187 T1926 T1924 pobj cassette,of
R1188 T1927 T1928 compound PGK,neo
R1189 T1928 T1926 compound neo,cassette
R1190 T1929 T1928 punct -,neo
R1191 T1930 T1918 punct ", ",led
R1192 T1931 T1918 cc and,led
R1193 T1932 T1933 nsubjpass mice,generated
R1194 T1933 T1918 conj generated,led
R1195 T1934 T1932 acl carrying,mice
R1196 T1935 T1936 det the,allele
R1197 T1936 T1934 dobj allele,carrying
R1198 T1937 T1936 amod modified,allele
R1199 T1938 T1936 compound Mtf1loxP,allele
R1200 T1939 T1933 auxpass were,generated
R1201 T1940 T1933 prep by,generated
R1202 T1941 T1940 pobj injection,by
R1203 T1942 T1941 prep of,injection
R1204 T1943 T1944 amod positive,clones
R1205 T1944 T1942 pobj clones,of
R1206 T1945 T1941 prep into,injection
R1207 T1946 T1947 nmod C57Bl,blastocysts
R1208 T1947 T1945 pobj blastocysts,into
R1209 T1948 T1946 punct /,C57Bl
R1210 T1949 T1946 nummod 6,C57Bl
R1211 T1950 T1947 cc and,blastocysts
R1212 T1951 T1952 amod subsequent,crosses
R1213 T1952 T1947 conj crosses,blastocysts
R1214 T1953 T1933 punct .,generated
R1215 T1955 T1956 amod Homozygous,animals
R1216 T1956 T1959 nsubjpass animals,crossed
R1217 T1957 T1958 amod conditional,knockout
R1218 T1958 T1956 compound knockout,animals
R1219 T1960 T1956 punct (,animals
R1220 T1961 T1962 compound Mtf1loxP,loxP
R1221 T1962 T1956 appos loxP,animals
R1222 T1963 T1962 punct /,loxP
R1223 T1964 T1959 punct ),crossed
R1224 T1965 T1959 auxpass were,crossed
R1225 T1966 T1959 prep with,crossed
R1226 T1967 T1968 det the,line
R1227 T1968 T1966 pobj line,with
R1228 T2074 T2075 compound Cre,recombinase
R1229 T2075 T2076 npadvmod recombinase,transgenic
R1230 T2076 T1968 amod transgenic,line
R1231 T2077 T2078 compound Mx,cre
R1232 T2078 T1968 appos cre,line
R1233 T2079 T2078 punct -,cre
R1234 T2080 T2081 punct (,gift
R1235 T2081 T1968 parataxis gift,line
R1236 T2082 T2081 det a,gift
R1237 T2083 T2081 prep from,gift
R1238 T2084 T2085 compound Prof.,Aguet
R1239 T2085 T2083 pobj Aguet,from
R1240 T2086 T2085 compound Michel,Aguet
R1241 T2087 T2081 punct ),gift
R1242 T2088 T2089 aux to,obtain
R1243 T2089 T1959 advcl obtain,crossed
R1244 T2090 T2091 det an,line
R1245 T2091 T2089 dobj line,obtain
R1246 T2092 T2091 amod inducible,line
R1247 T2093 T2091 punct ", ",line
R1248 T2094 T2095 npadvmod liver,specific
R1249 T2095 T2091 amod specific,line
R1250 T2096 T2095 punct -,specific
R1251 T2097 T2098 compound Mtf1,knockout
R1252 T2098 T2091 compound knockout,line
R1253 T2099 T1959 punct .,crossed
R1254 T2101 T2102 det The,mice
R1255 T2102 T2103 nsubjpass mice,genotyped
R1256 T2104 T2103 auxpass were,genotyped
R1257 T2105 T2103 prep by,genotyped
R1258 T2106 T2105 pobj PCR,by
R1259 T2107 T2103 advcl using,genotyped
R1260 T2108 T2109 det the,primers
R1261 T2109 T2107 dobj primers,using
R1262 T2110 T2109 amod following,primers
R1263 T2111 T2112 punct (,Microsynth
R1264 T2112 T2109 parataxis Microsynth,primers
R1265 T2113 T2112 punct ),Microsynth
R1266 T2114 T2103 punct : ,genotyped
R1267 T2115 T2116 compound Cre,recombinase
R1268 T2116 T2117 dep recombinase,CCAGGTTACGGATATAGTTCATGAC
R1269 T2117 T2130 dep CCAGGTTACGGATATAGTTCATGAC,CAGTCACAAGCAAATTACCAAACACTGCC
R1270 T2118 T2117 punct : ,CCAGGTTACGGATATAGTTCATGAC
R1271 T2119 T2120 nummod 5,CTATCCAGCAACATTTGGGCCAGC
R1272 T2120 T2117 dep CTATCCAGCAACATTTGGGCCAGC,CCAGGTTACGGATATAGTTCATGAC
R1273 T2121 T2119 punct ′,5
R1274 T2122 T2120 punct -,CTATCCAGCAACATTTGGGCCAGC
R1275 T2123 T2120 punct -,CTATCCAGCAACATTTGGGCCAGC
R1276 T2124 T2120 nummod 3,CTATCCAGCAACATTTGGGCCAGC
R1277 T2125 T2120 punct ′,CTATCCAGCAACATTTGGGCCAGC
R1278 T2126 T2117 punct ;,CCAGGTTACGGATATAGTTCATGAC
R1279 T2127 T2117 nummod 5,CCAGGTTACGGATATAGTTCATGAC
R1280 T2128 T2127 punct ′,5
R1281 T2129 T2117 punct -,CCAGGTTACGGATATAGTTCATGAC
R1282 T2130 T2103 dep CAGTCACAAGCAAATTACCAAACACTGCC,genotyped
R1283 T2131 T2117 punct -,CCAGGTTACGGATATAGTTCATGAC
R1284 T2132 T2117 nummod 3,CCAGGTTACGGATATAGTTCATGAC
R1285 T2133 T2117 punct ′,CCAGGTTACGGATATAGTTCATGAC
R1286 T2134 T2130 punct ", ",CAGTCACAAGCAAATTACCAAACACTGCC
R1287 T2135 T2130 dep Mtf1loxP,CAGTCACAAGCAAATTACCAAACACTGCC
R1288 T2136 T2135 cc or,Mtf1loxP
R1289 T2137 T2138 amod wild,type
R1290 T2138 T2140 compound type,allele
R1291 T2139 T2138 punct -,type
R1292 T2140 T2135 conj allele,Mtf1loxP
R1293 T2141 T2130 punct : ,CAGTCACAAGCAAATTACCAAACACTGCC
R1294 T2142 T2143 nummod 5,CACACCCAGTTTGTGTATGTCTTC
R1295 T2143 T2130 dep CACACCCAGTTTGTGTATGTCTTC,CAGTCACAAGCAAATTACCAAACACTGCC
R1296 T2144 T2142 punct ′,5
R1297 T2145 T2143 punct -,CACACCCAGTTTGTGTATGTCTTC
R1298 T2146 T2143 punct -,CACACCCAGTTTGTGTATGTCTTC
R1299 T2147 T2143 nummod 3,CACACCCAGTTTGTGTATGTCTTC
R1300 T2148 T2143 punct ′,CACACCCAGTTTGTGTATGTCTTC
R1301 T2149 T2130 punct ;,CAGTCACAAGCAAATTACCAAACACTGCC
R1302 T2150 T2130 nummod 5,CAGTCACAAGCAAATTACCAAACACTGCC
R1303 T2151 T2150 punct ′,5
R1304 T2152 T2130 punct -,CAGTCACAAGCAAATTACCAAACACTGCC
R1305 T2153 T2130 punct -,CAGTCACAAGCAAATTACCAAACACTGCC
R1306 T2154 T2130 nummod 3,CAGTCACAAGCAAATTACCAAACACTGCC
R1307 T2155 T2130 punct ′,CAGTCACAAGCAAATTACCAAACACTGCC
R1308 T2156 T2103 punct .,genotyped

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T1972 0-4 PR:000010717 denotes Mtf1
T1973 26-30 NCBITaxon:10088 denotes mice
T1974 109-123 SO:0000040 denotes genomic clones
T1975 135-140 SO:0000147 denotes exons
T1976 151-155 PR:000010717 denotes Mtf1
T1977 181-185 SO:0000704 denotes gene
T1978 186-202 SO:0001644 denotes targeting vector
T1979 256-264 CHEBI:7507 denotes neomycin
T1980 276-284 SO:0005853 denotes cassette
T1981 295-302 SO:0000357 denotes flanked
T1982 310-320 SO:0000346 denotes loxP sites
T1983 357-361 SO:0000147 denotes exon
T1984 367-371 PR:000010717 denotes Mtf1
T1985 383-392 SO:0000346 denotes loxP site
T1986 429-433 SO:0000147 denotes exon
T1987 461-469 SO:0005853 denotes cassette
T1988 506-510 SO:0000147 denotes exon
T1989 518-526 CL:0002322 denotes ES cells
T1990 567-583 SO:0001644 denotes targeting vector
T1991 613-617 CHEBI:42768 denotes G418
T1992 717-727 GO:0010467 denotes expression
T1993 777-785 SO:0005853 denotes cassette
T1994 791-795 NCBITaxon:10088 denotes mice
T1995 818-822 PR:000010717 denotes Mtf1
T1996 822-826 SO:0000346 denotes loxP
T1997 827-833 SO:0001023 denotes allele
T1998 894-905 UBERON:0000358 denotes blastocysts
T1999 962-969 NCBITaxon:33208 denotes animals
T2000 971-975 PR:000010717 denotes Mtf1
T2001 975-979 SO:0000346 denotes loxP
T2002 980-984 SO:0000346 denotes loxP
T2003 1040-1042 PR:000010788 denotes Mx
T2004 1104-1109 UBERON:0002107 denotes liver
T2005 1119-1123 PR:000010717 denotes Mtf1
T2006 1143-1147 NCBITaxon:10088 denotes mice
T2007 1190-1197 SO:0000112 denotes primers
T2008 1294-1298 PR:000010717 denotes Mtf1
T2009 1298-1302 SO:0000346 denotes loxP
T2010 1316-1322 SO:0001023 denotes allele

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2015 0-4 PR_EXT:000010717 denotes Mtf1
T2016 26-30 NCBITaxon:10088 denotes mice
T2017 109-123 SO_EXT:0000040 denotes genomic clones
T2018 135-140 SO_EXT:0000147 denotes exons
T2019 151-155 PR_EXT:000010717 denotes Mtf1
T2020 181-185 SO_EXT:0000704 denotes gene
T2021 186-202 SO_EXT:0001644 denotes targeting vector
T2022 218-231 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T2024 276-284 SO_EXT:0005853 denotes cassette
T2025 286-289 GO_EXT:phosphoglycerate_kinase denotes PGK
T2026 290-293 CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase denotes neo
T2027 295-302 SO:0000357 denotes flanked
T2028 310-320 SO_EXT:0000346 denotes loxP sites
T2029 325-331 SO_EXT:sequence_cloning_process denotes cloned
T2030 357-361 SO_EXT:0000147 denotes exon
T2031 367-371 PR_EXT:000010717 denotes Mtf1
T2032 383-392 SO_EXT:0000346 denotes loxP site
T2033 397-403 SO_EXT:sequence_cloning_process denotes cloned
T2034 429-433 SO_EXT:0000147 denotes exon
T2035 439-448 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymidine
T2036 439-455 GO_PR_EXT:thymidine_kinase denotes thymidine kinase
T2037 457-459 GO_PR_EXT:thymidine_kinase denotes TK
T2038 461-469 SO_EXT:0005853 denotes cassette
T2039 474-482 SO_EXT:sequence_insertion_process denotes inserted
T2040 506-510 SO_EXT:0000147 denotes exon
T2041 518-526 CL:0002322 denotes ES cells
T2042 521-526 CL_GO_EXT:cell denotes cells
T2043 556-566 SO_EXT:sequence_linearization denotes linearized
T2044 567-583 SO_EXT:0001644 denotes targeting vector
T2045 613-617 CHEBI:42768 denotes G418
T2046 717-727 GO:0010467 denotes expression
T2047 735-746 GO_EXT:recombinase denotes recombinase
T2048 769-772 GO_EXT:phosphoglycerate_kinase denotes PGK
T2049 773-776 CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase denotes neo
T2050 777-785 SO_EXT:0005853 denotes cassette
T2051 791-795 NCBITaxon:10088 denotes mice
T2052 809-817 SO_EXT:sequence_alteration_process denotes modified
T2053 818-822 PR_EXT:000010717 denotes Mtf1
T2054 822-826 SO_EXT:0000346 denotes loxP
T2055 827-833 SO_EXT:0001023 denotes allele
T2056 874-880 SO_EXT:sequence_cloned_entity denotes clones
T2057 894-905 UBERON:0000358 denotes blastocysts
T2058 962-969 NCBITaxon:33208 denotes animals
T2059 971-975 PR_EXT:000010717 denotes Mtf1
T2060 975-979 SO_EXT:0000346 denotes loxP
T2061 980-984 SO_EXT:0000346 denotes loxP
T2062 1012-1023 GO_EXT:recombinase denotes recombinase
T2063 1024-1034 SO_EXT:transgenic_entity denotes transgenic
T2064 1040-1042 PR_EXT:000010788 denotes Mx
T2065 1104-1109 UBERON:0002107 denotes liver
T2066 1119-1123 PR_EXT:000010717 denotes Mtf1
T2067 1143-1147 NCBITaxon:10088 denotes mice
T2068 1190-1197 SO_EXT:0000112 denotes primers
T2069 1216-1227 GO_EXT:recombinase denotes recombinase
T2070 1294-1298 PR_EXT:000010717 denotes Mtf1
T2071 1298-1302 SO_EXT:0000346 denotes loxP
T2072 1306-1315 SO_EXT:wild_type_entity_or_quality denotes wild-type
T2073 1316-1322 SO_EXT:0001023 denotes allele
T2023 256-264 CHEBI:7507 denotes neomycin