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PMC:1253828 / 5408-6873 JSONTXT

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Id Subject Object Predicate Lexical cue
T1758 0-10 NN denotes Generation
T1759 11-13 IN denotes of
T1760 14-18 NN denotes Mtf1
T1761 40-44 NNS denotes mice
T1762 19-30 JJ denotes conditional
T1763 31-39 NN denotes knockout
T1764 45-48 CC denotes and
T1765 49-54 NN denotes liver
T1766 55-63 JJ denotes specific
T1767 54-55 HYPH denotes -
T1768 64-72 NN denotes deletion
T1769 72-177 sentence denotes Mtf1 conditional knockout mice were generated in collaboration with Dr Michael Leviten (San Carlos, CA).
T1770 73-77 NN denotes Mtf1
T1771 99-103 NNS denotes mice
T1772 78-89 JJ denotes conditional
T1773 90-98 NN denotes knockout
T1774 109-118 VBN denotes generated
T1775 104-108 VBD denotes were
T1776 119-121 IN denotes in
T1777 122-135 NN denotes collaboration
T1778 136-140 IN denotes with
T1779 141-143 NNP denotes Dr
T1780 152-159 NNP denotes Leviten
T1781 144-151 NNP denotes Michael
T1782 160-161 -LRB- denotes (
T1783 165-171 NNP denotes Carlos
T1784 161-164 NNP denotes San
T1785 171-173 , denotes ,
T1786 173-175 NNP denotes CA
T1787 175-176 -RRB- denotes )
T1788 176-177 . denotes .
T1789 177-326 sentence denotes Two genomic clones containing exons 3 to 6 of Mtf1 were used to construct a gene targeting vector for homologous recombination (Supplementary Data).
T1790 178-181 CD denotes Two
T1791 190-196 NNS denotes clones
T1792 182-189 JJ denotes genomic
T1793 234-238 VBN denotes used
T1794 197-207 VBG denotes containing
T1795 208-213 NNS denotes exons
T1796 214-215 CD denotes 3
T1797 216-218 IN denotes to
T1798 219-220 CD denotes 6
T1799 221-223 IN denotes of
T1800 224-228 NN denotes Mtf1
T1801 229-233 VBD denotes were
T1802 239-241 TO denotes to
T1803 242-251 VB denotes construct
T1804 252-253 DT denotes a
T1805 269-275 NN denotes vector
T1806 254-258 NN denotes gene
T1807 259-268 NN denotes targeting
T1808 276-279 IN denotes for
T1809 280-290 JJ denotes homologous
T1810 291-304 NN denotes recombination
T1811 305-306 -LRB- denotes (
T1812 320-324 NNS denotes Data
T1813 306-319 JJ denotes Supplementary
T1814 324-325 -RRB- denotes )
T1815 325-326 . denotes .
T1816 326-509 sentence denotes A neomycin resistance cassette (PGK-neo) flanked by two loxP sites was cloned into the SacI site 5′ of exon 3 of Mtf1, the third loxP site was cloned into the ScaI site 3′ of exon 4.
T1817 327-328 DT denotes A
T1818 349-357 NN denotes cassette
T1819 329-337 NN denotes neomycin
T1820 338-348 NN denotes resistance
T1821 398-404 VBN denotes cloned
T1822 358-359 -LRB- denotes (
T1823 359-362 NN denotes PGK
T1824 363-366 NN denotes neo
T1825 362-363 HYPH denotes -
T1826 366-367 -RRB- denotes )
T1827 368-375 VBN denotes flanked
T1828 376-378 IN denotes by
T1829 379-382 CD denotes two
T1830 388-393 NNS denotes sites
T1831 383-387 NN denotes loxP
T1832 394-397 VBD denotes was
T1833 470-476 VBN denotes cloned
T1834 405-409 IN denotes into
T1835 410-413 DT denotes the
T1836 419-423 NN denotes site
T1837 414-418 NN denotes SacI
T1838 424-425 CD denotes 5
T1839 425-426 SYM denotes ′
T1840 427-429 IN denotes of
T1841 430-434 NN denotes exon
T1842 435-436 CD denotes 3
T1843 437-439 IN denotes of
T1844 440-444 NN denotes Mtf1
T1845 444-446 , denotes ,
T1846 446-449 DT denotes the
T1847 461-465 NN denotes site
T1848 450-455 JJ denotes third
T1849 456-460 NN denotes loxP
T1850 466-469 VBD denotes was
T1851 477-481 IN denotes into
T1852 482-485 DT denotes the
T1853 491-495 NN denotes site
T1854 486-490 NN denotes ScaI
T1855 496-497 CD denotes 3
T1856 497-498 SYM denotes ′
T1857 499-501 IN denotes of
T1858 502-506 NN denotes exon
T1859 507-508 CD denotes 4
T1860 508-509 . denotes .
T1861 509-586 sentence denotes A thymidine kinase (TK) cassette was inserted in the HpaI site 3′ of exon 6.
T1862 510-511 DT denotes A
T1863 534-542 NN denotes cassette
T1864 512-521 NN denotes thymidine
T1865 522-528 NN denotes kinase
T1866 529-530 -LRB- denotes (
T1867 530-532 NN denotes TK
T1868 532-533 -RRB- denotes )
T1869 547-555 VBN denotes inserted
T1870 543-546 VBD denotes was
T1871 556-558 IN denotes in
T1872 559-562 DT denotes the
T1873 568-572 NN denotes site
T1874 563-567 NN denotes HpaI
T1875 573-574 CD denotes 3
T1876 574-575 SYM denotes ′
T1877 576-578 IN denotes of
T1878 579-583 NN denotes exon
T1879 584-585 CD denotes 6
T1880 585-586 . denotes .
T1881 586-779 sentence denotes 129 ES cells were electroporated with the linearized targeting vector, selected in the presence of G418 and FIAU, and screened for correct integration events by PCR and Southern blot analysis.
T1882 587-590 CD denotes 129
T1883 594-599 NNS denotes cells
T1884 591-593 NN denotes ES
T1885 605-619 VBN denotes electroporated
T1886 600-604 VBD denotes were
T1887 620-624 IN denotes with
T1888 625-628 DT denotes the
T1889 650-656 NN denotes vector
T1890 629-639 VBN denotes linearized
T1891 640-649 NN denotes targeting
T1892 656-658 , denotes ,
T1893 658-666 VBN denotes selected
T1894 667-669 IN denotes in
T1895 670-673 DT denotes the
T1896 674-682 NN denotes presence
T1897 683-685 IN denotes of
T1898 686-690 NN denotes G418
T1899 691-694 CC denotes and
T1900 695-699 NN denotes FIAU
T1901 699-701 , denotes ,
T1902 701-704 CC denotes and
T1903 705-713 VBN denotes screened
T1904 714-717 IN denotes for
T1905 718-725 JJ denotes correct
T1906 738-744 NNS denotes events
T1907 726-737 NN denotes integration
T1908 745-747 IN denotes by
T1909 748-751 NN denotes PCR
T1910 770-778 NN denotes analysis
T1911 752-755 CC denotes and
T1912 756-764 NNP denotes Southern
T1913 765-769 NN denotes blot
T1914 778-779 . denotes .
T1915 779-1002 sentence denotes Transient expression of Cre recombinase led to removal of the PGK-neo cassette, and mice carrying the modified Mtf1loxP allele were generated by injection of positive clones into C57Bl/6 blastocysts and subsequent crosses.
T1916 780-789 JJ denotes Transient
T1917 790-800 NN denotes expression
T1918 820-823 VBD denotes led
T1919 801-803 IN denotes of
T1920 804-807 NN denotes Cre
T1921 808-819 NN denotes recombinase
T1922 824-826 IN denotes to
T1923 827-834 NN denotes removal
T1924 835-837 IN denotes of
T1925 838-841 DT denotes the
T1926 850-858 NN denotes cassette
T1927 842-845 NN denotes PGK
T1928 846-849 NN denotes neo
T1929 845-846 HYPH denotes -
T1930 858-860 , denotes ,
T1931 860-863 CC denotes and
T1932 864-868 NNS denotes mice
T1933 912-921 VBN denotes generated
T1934 869-877 VBG denotes carrying
T1935 878-881 DT denotes the
T1936 900-906 NN denotes allele
T1937 882-890 VBN denotes modified
T1938 891-899 NN denotes Mtf1loxP
T1939 907-911 VBD denotes were
T1940 922-924 IN denotes by
T1941 925-934 NN denotes injection
T1942 935-937 IN denotes of
T1943 938-946 JJ denotes positive
T1944 947-953 NNS denotes clones
T1945 954-958 IN denotes into
T1946 959-964 NN denotes C57Bl
T1947 967-978 NNS denotes blastocysts
T1948 964-965 HYPH denotes /
T1949 965-966 CD denotes 6
T1950 979-982 CC denotes and
T1951 983-993 JJ denotes subsequent
T1952 994-1001 NNS denotes crosses
T1953 1001-1002 . denotes .
T1955 1003-1013 JJ denotes Homozygous
T1956 1035-1042 NNS denotes animals
T1957 1014-1025 JJ denotes conditional
T1958 1026-1034 NN denotes knockout
T1959 1064-1071 VBN denotes crossed
T1960 1043-1044 -LRB- denotes (
T1961 1044-1052 NN denotes Mtf1loxP
T1962 1053-1057 NN denotes loxP
T1963 1052-1053 HYPH denotes /
T1964 1057-1058 -RRB- denotes )
T1965 1059-1063 VBD denotes were
T1966 1072-1076 IN denotes with
T1967 1077-1080 DT denotes the
T1968 1108-1112 NN denotes line
T2099 1210-1211 . denotes .
T2100 1211-1465 sentence denotes The mice were genotyped by PCR using the following primers (Microsynth): Cre recombinase: 5′-CTATCCAGCAACATTTGGGCCAGC-3′; 5′-CCAGGTTACGGATATAGTTCATGAC-3′, Mtf1loxP or wild-type allele: 5′-CACACCCAGTTTGTGTATGTCTTC-3′; 5′-CAGTCACAAGCAAATTACCAAACACTGCC-3′.
T2101 1212-1215 DT denotes The
T2102 1216-1220 NNS denotes mice
T2103 1226-1235 VBN denotes genotyped
T2104 1221-1225 VBD denotes were
T2105 1236-1238 IN denotes by
T2106 1239-1242 NN denotes PCR
T2107 1243-1248 VBG denotes using
T2108 1249-1252 DT denotes the
T2109 1263-1270 NNS denotes primers
T2110 1253-1262 VBG denotes following
T2111 1271-1272 -LRB- denotes (
T2112 1272-1282 NNP denotes Microsynth
T2113 1282-1283 -RRB- denotes )
T2114 1283-1285 : denotes :
T2115 1285-1288 NN denotes Cre
T2116 1289-1300 NN denotes recombinase
T2117 1337-1362 NN denotes CCAGGTTACGGATATAGTTCATGAC
T2118 1300-1302 : denotes :
T2119 1302-1303 CD denotes 5
T2120 1305-1329 NN denotes CTATCCAGCAACATTTGGGCCAGC
T2121 1303-1304 SYM denotes ′
T2122 1304-1305 HYPH denotes -
T2123 1329-1330 HYPH denotes -
T2124 1330-1331 CD denotes 3
T2125 1331-1332 SYM denotes ′
T2126 1332-1333 : denotes ;
T2127 1334-1335 CD denotes 5
T2128 1335-1336 SYM denotes ′
T2129 1336-1337 HYPH denotes -
T2130 1432-1461 NN denotes CAGTCACAAGCAAATTACCAAACACTGCC
T2131 1362-1363 HYPH denotes -
T2132 1363-1364 CD denotes 3
T2133 1364-1365 SYM denotes ′
T2134 1365-1367 , denotes ,
T2135 1367-1375 NN denotes Mtf1loxP
T2136 1376-1378 CC denotes or
T2137 1379-1383 JJ denotes wild
T2138 1384-1388 NN denotes type
T2139 1383-1384 HYPH denotes -
T2140 1389-1395 NN denotes allele
T2141 1395-1397 : denotes :
T2142 1397-1398 CD denotes 5
T2143 1400-1424 NN denotes CACACCCAGTTTGTGTATGTCTTC
T2144 1398-1399 SYM denotes ′
T2145 1399-1400 HYPH denotes -
T2146 1424-1425 HYPH denotes -
T2147 1425-1426 CD denotes 3
T2148 1426-1427 SYM denotes ′
T2149 1427-1428 : denotes ;
T2150 1429-1430 CD denotes 5
T2151 1430-1431 SYM denotes ′
T2152 1431-1432 HYPH denotes -
T2153 1461-1462 HYPH denotes -
T2154 1462-1463 CD denotes 3
T2155 1463-1464 SYM denotes ′
T2156 1464-1465 . denotes .
T1954 1002-1211 sentence denotes Homozygous conditional knockout animals (Mtf1loxP/loxP) were crossed with the Cre recombinase transgenic line Mx-cre (a gift from Prof. Michel Aguet) to obtain an inducible, liver-specific Mtf1 knockout line.
T2075 1085-1096 NN denotes recombinase
T2076 1097-1107 JJ denotes transgenic
T2077 1113-1115 NN denotes Mx
T2078 1116-1119 NN denotes cre
T2079 1115-1116 HYPH denotes -
T2080 1120-1121 -LRB- denotes (
T2081 1123-1127 NN denotes gift
T2082 1121-1122 DT denotes a
T2083 1128-1132 IN denotes from
T2084 1133-1138 NNP denotes Prof.
T2085 1146-1151 NNP denotes Aguet
T2086 1139-1145 NNP denotes Michel
T2087 1151-1152 -RRB- denotes )
T2088 1153-1155 TO denotes to
T2089 1156-1162 VB denotes obtain
T2090 1163-1165 DT denotes an
T2091 1206-1210 NN denotes line
T2092 1166-1175 JJ denotes inducible
T2093 1175-1177 , denotes ,
T2094 1177-1182 NN denotes liver
T2095 1183-1191 JJ denotes specific
T2096 1182-1183 HYPH denotes -
T2097 1192-1196 NN denotes Mtf1
T2098 1197-1205 NN denotes knockout
T2074 1081-1084 NN denotes Cre
R1032 T1759 T1758 prep of,Generation
R1033 T1760 T1761 nmod Mtf1,mice
R1034 T1761 T1759 pobj mice,of
R1035 T1762 T1763 amod conditional,knockout
R1036 T1763 T1761 compound knockout,mice
R1037 T1764 T1761 cc and,mice
R1038 T1765 T1766 npadvmod liver,specific
R1039 T1766 T1768 amod specific,deletion
R1040 T1767 T1766 punct -,specific
R1041 T1768 T1761 conj deletion,mice
R1042 T1770 T1771 nmod Mtf1,mice
R1043 T1771 T1774 nsubjpass mice,generated
R1044 T1772 T1773 amod conditional,knockout
R1045 T1773 T1771 compound knockout,mice
R1046 T1775 T1774 auxpass were,generated
R1047 T1776 T1774 prep in,generated
R1048 T1777 T1776 pobj collaboration,in
R1049 T1778 T1777 prep with,collaboration
R1050 T1779 T1780 compound Dr,Leviten
R1051 T1780 T1778 pobj Leviten,with
R1052 T1781 T1780 compound Michael,Leviten
R1053 T1782 T1783 punct (,Carlos
R1054 T1783 T1780 parataxis Carlos,Leviten
R1055 T1784 T1783 compound San,Carlos
R1056 T1785 T1783 punct ", ",Carlos
R1057 T1786 T1783 npadvmod CA,Carlos
R1058 T1787 T1783 punct ),Carlos
R1059 T1788 T1774 punct .,generated
R1060 T1790 T1791 nummod Two,clones
R1061 T1791 T1793 nsubjpass clones,used
R1062 T1792 T1791 amod genomic,clones
R1063 T1794 T1791 acl containing,clones
R1064 T1795 T1796 nmod exons,3
R1065 T1796 T1794 dobj 3,containing
R1066 T1797 T1796 prep to,3
R1067 T1798 T1797 pobj 6,to
R1068 T1799 T1796 prep of,3
R1069 T1800 T1799 pobj Mtf1,of
R1070 T1801 T1793 auxpass were,used
R1071 T1802 T1803 aux to,construct
R1072 T1803 T1793 advcl construct,used
R1073 T1804 T1805 det a,vector
R1074 T1805 T1803 dobj vector,construct
R1075 T1806 T1807 compound gene,targeting
R1076 T1807 T1805 compound targeting,vector
R1077 T1808 T1803 prep for,construct
R1078 T1809 T1810 amod homologous,recombination
R1079 T1810 T1808 pobj recombination,for
R1080 T1811 T1812 punct (,Data
R1081 T1812 T1803 parataxis Data,construct
R1082 T1813 T1812 amod Supplementary,Data
R1083 T1814 T1812 punct ),Data
R1084 T1815 T1793 punct .,used
R1085 T1817 T1818 det A,cassette
R1086 T1818 T1821 nsubjpass cassette,cloned
R1087 T1819 T1818 compound neomycin,cassette
R1088 T1820 T1818 compound resistance,cassette
R1089 T1821 T1833 ccomp cloned,cloned
R1090 T1822 T1818 punct (,cassette
R1091 T1823 T1824 compound PGK,neo
R1092 T1824 T1818 appos neo,cassette
R1093 T1825 T1824 punct -,neo
R1094 T1826 T1818 punct ),cassette
R1095 T1827 T1818 acl flanked,cassette
R1096 T1828 T1827 agent by,flanked
R1097 T1829 T1830 nummod two,sites
R1098 T1830 T1828 pobj sites,by
R1099 T1831 T1830 compound loxP,sites
R1100 T1832 T1821 auxpass was,cloned
R1101 T1834 T1821 prep into,cloned
R1102 T1835 T1836 det the,site
R1103 T1836 T1834 pobj site,into
R1104 T1837 T1836 compound SacI,site
R1105 T1838 T1836 npadvmod 5,site
R1106 T1839 T1838 punct ′,5
R1107 T1840 T1838 prep of,5
R1108 T1841 T1840 pobj exon,of
R1109 T1842 T1841 nummod 3,exon
R1110 T1843 T1841 prep of,exon
R1111 T1844 T1843 pobj Mtf1,of
R1112 T1845 T1833 punct ", ",cloned
R1113 T1846 T1847 det the,site
R1114 T1847 T1833 nsubjpass site,cloned
R1115 T1848 T1847 amod third,site
R1116 T1849 T1847 compound loxP,site
R1117 T1850 T1833 auxpass was,cloned
R1118 T1851 T1833 prep into,cloned
R1119 T1852 T1853 det the,site
R1120 T1853 T1851 pobj site,into
R1121 T1854 T1853 compound ScaI,site
R1122 T1855 T1853 npadvmod 3,site
R1123 T1856 T1855 punct ′,3
R1124 T1857 T1855 prep of,3
R1125 T1858 T1857 pobj exon,of
R1126 T1859 T1858 nummod 4,exon
R1127 T1860 T1833 punct .,cloned
R1128 T1862 T1863 det A,cassette
R1129 T1863 T1869 nsubjpass cassette,inserted
R1130 T1864 T1865 nmod thymidine,kinase
R1131 T1865 T1863 nmod kinase,cassette
R1132 T1866 T1865 punct (,kinase
R1133 T1867 T1865 appos TK,kinase
R1134 T1868 T1863 punct ),cassette
R1135 T1870 T1869 auxpass was,inserted
R1136 T1871 T1869 prep in,inserted
R1137 T1872 T1873 det the,site
R1138 T1873 T1871 pobj site,in
R1139 T1874 T1873 compound HpaI,site
R1140 T1875 T1873 npadvmod 3,site
R1141 T1876 T1875 punct ′,3
R1142 T1877 T1875 prep of,3
R1143 T1878 T1877 pobj exon,of
R1144 T1879 T1878 nummod 6,exon
R1145 T1880 T1869 punct .,inserted
R1146 T1882 T1883 nummod 129,cells
R1147 T1883 T1885 nsubjpass cells,electroporated
R1148 T1884 T1883 compound ES,cells
R1149 T1886 T1885 auxpass were,electroporated
R1150 T1887 T1885 prep with,electroporated
R1151 T1888 T1889 det the,vector
R1152 T1889 T1887 pobj vector,with
R1153 T1890 T1889 amod linearized,vector
R1154 T1891 T1889 compound targeting,vector
R1155 T1892 T1889 punct ", ",vector
R1156 T1893 T1889 acl selected,vector
R1157 T1894 T1893 prep in,selected
R1158 T1895 T1896 det the,presence
R1159 T1896 T1894 pobj presence,in
R1160 T1897 T1896 prep of,presence
R1161 T1898 T1897 pobj G418,of
R1162 T1899 T1898 cc and,G418
R1163 T1900 T1898 conj FIAU,G418
R1164 T1901 T1885 punct ", ",electroporated
R1165 T1902 T1885 cc and,electroporated
R1166 T1903 T1885 conj screened,electroporated
R1167 T1904 T1903 prep for,screened
R1168 T1905 T1906 amod correct,events
R1169 T1906 T1904 pobj events,for
R1170 T1907 T1906 compound integration,events
R1171 T1908 T1903 prep by,screened
R1172 T1909 T1910 nmod PCR,analysis
R1173 T1910 T1908 pobj analysis,by
R1174 T1911 T1909 cc and,PCR
R1175 T1912 T1913 compound Southern,blot
R1176 T1913 T1909 conj blot,PCR
R1177 T1914 T1885 punct .,electroporated
R1178 T1916 T1917 amod Transient,expression
R1179 T1917 T1918 nsubj expression,led
R1180 T1919 T1917 prep of,expression
R1181 T1920 T1921 compound Cre,recombinase
R1182 T1921 T1919 pobj recombinase,of
R1183 T1922 T1918 prep to,led
R1184 T1923 T1922 pobj removal,to
R1185 T1924 T1923 prep of,removal
R1186 T1925 T1926 det the,cassette
R1187 T1926 T1924 pobj cassette,of
R1188 T1927 T1928 compound PGK,neo
R1189 T1928 T1926 compound neo,cassette
R1190 T1929 T1928 punct -,neo
R1191 T1930 T1918 punct ", ",led
R1192 T1931 T1918 cc and,led
R1193 T1932 T1933 nsubjpass mice,generated
R1194 T1933 T1918 conj generated,led
R1195 T1934 T1932 acl carrying,mice
R1196 T1935 T1936 det the,allele
R1197 T1936 T1934 dobj allele,carrying
R1198 T1937 T1936 amod modified,allele
R1199 T1938 T1936 compound Mtf1loxP,allele
R1200 T1939 T1933 auxpass were,generated
R1201 T1940 T1933 prep by,generated
R1202 T1941 T1940 pobj injection,by
R1203 T1942 T1941 prep of,injection
R1204 T1943 T1944 amod positive,clones
R1205 T1944 T1942 pobj clones,of
R1206 T1945 T1941 prep into,injection
R1207 T1946 T1947 nmod C57Bl,blastocysts
R1208 T1947 T1945 pobj blastocysts,into
R1209 T1948 T1946 punct /,C57Bl
R1210 T1949 T1946 nummod 6,C57Bl
R1211 T1950 T1947 cc and,blastocysts
R1212 T1951 T1952 amod subsequent,crosses
R1213 T1952 T1947 conj crosses,blastocysts
R1214 T1953 T1933 punct .,generated
R1215 T1955 T1956 amod Homozygous,animals
R1216 T1956 T1959 nsubjpass animals,crossed
R1217 T1957 T1958 amod conditional,knockout
R1218 T1958 T1956 compound knockout,animals
R1219 T1960 T1956 punct (,animals
R1220 T1961 T1962 compound Mtf1loxP,loxP
R1221 T1962 T1956 appos loxP,animals
R1222 T1963 T1962 punct /,loxP
R1223 T1964 T1959 punct ),crossed
R1224 T1965 T1959 auxpass were,crossed
R1225 T1966 T1959 prep with,crossed
R1226 T1967 T1968 det the,line
R1227 T1968 T1966 pobj line,with
R1228 T2074 T2075 compound Cre,recombinase
R1229 T2075 T2076 npadvmod recombinase,transgenic
R1230 T2076 T1968 amod transgenic,line
R1231 T2077 T2078 compound Mx,cre
R1232 T2078 T1968 appos cre,line
R1233 T2079 T2078 punct -,cre
R1234 T2080 T2081 punct (,gift
R1235 T2081 T1968 parataxis gift,line
R1236 T2082 T2081 det a,gift
R1237 T2083 T2081 prep from,gift
R1238 T2084 T2085 compound Prof.,Aguet
R1239 T2085 T2083 pobj Aguet,from
R1240 T2086 T2085 compound Michel,Aguet
R1241 T2087 T2081 punct ),gift
R1242 T2088 T2089 aux to,obtain
R1243 T2089 T1959 advcl obtain,crossed
R1244 T2090 T2091 det an,line
R1245 T2091 T2089 dobj line,obtain
R1246 T2092 T2091 amod inducible,line
R1247 T2093 T2091 punct ", ",line
R1248 T2094 T2095 npadvmod liver,specific
R1249 T2095 T2091 amod specific,line
R1250 T2096 T2095 punct -,specific
R1251 T2097 T2098 compound Mtf1,knockout
R1252 T2098 T2091 compound knockout,line
R1253 T2099 T1959 punct .,crossed
R1254 T2101 T2102 det The,mice
R1255 T2102 T2103 nsubjpass mice,genotyped
R1256 T2104 T2103 auxpass were,genotyped
R1257 T2105 T2103 prep by,genotyped
R1258 T2106 T2105 pobj PCR,by
R1259 T2107 T2103 advcl using,genotyped
R1260 T2108 T2109 det the,primers
R1261 T2109 T2107 dobj primers,using
R1262 T2110 T2109 amod following,primers
R1263 T2111 T2112 punct (,Microsynth
R1264 T2112 T2109 parataxis Microsynth,primers
R1265 T2113 T2112 punct ),Microsynth
R1266 T2114 T2103 punct : ,genotyped
R1267 T2115 T2116 compound Cre,recombinase
R1268 T2116 T2117 dep recombinase,CCAGGTTACGGATATAGTTCATGAC
R1269 T2117 T2130 dep CCAGGTTACGGATATAGTTCATGAC,CAGTCACAAGCAAATTACCAAACACTGCC
R1270 T2118 T2117 punct : ,CCAGGTTACGGATATAGTTCATGAC
R1271 T2119 T2120 nummod 5,CTATCCAGCAACATTTGGGCCAGC
R1272 T2120 T2117 dep CTATCCAGCAACATTTGGGCCAGC,CCAGGTTACGGATATAGTTCATGAC
R1273 T2121 T2119 punct ′,5
R1274 T2122 T2120 punct -,CTATCCAGCAACATTTGGGCCAGC
R1275 T2123 T2120 punct -,CTATCCAGCAACATTTGGGCCAGC
R1276 T2124 T2120 nummod 3,CTATCCAGCAACATTTGGGCCAGC
R1277 T2125 T2120 punct ′,CTATCCAGCAACATTTGGGCCAGC
R1278 T2126 T2117 punct ;,CCAGGTTACGGATATAGTTCATGAC
R1279 T2127 T2117 nummod 5,CCAGGTTACGGATATAGTTCATGAC
R1280 T2128 T2127 punct ′,5
R1281 T2129 T2117 punct -,CCAGGTTACGGATATAGTTCATGAC
R1282 T2130 T2103 dep CAGTCACAAGCAAATTACCAAACACTGCC,genotyped
R1283 T2131 T2117 punct -,CCAGGTTACGGATATAGTTCATGAC
R1284 T2132 T2117 nummod 3,CCAGGTTACGGATATAGTTCATGAC
R1285 T2133 T2117 punct ′,CCAGGTTACGGATATAGTTCATGAC
R1286 T2134 T2130 punct ", ",CAGTCACAAGCAAATTACCAAACACTGCC
R1287 T2135 T2130 dep Mtf1loxP,CAGTCACAAGCAAATTACCAAACACTGCC
R1288 T2136 T2135 cc or,Mtf1loxP
R1289 T2137 T2138 amod wild,type
R1290 T2138 T2140 compound type,allele
R1291 T2139 T2138 punct -,type
R1292 T2140 T2135 conj allele,Mtf1loxP
R1293 T2141 T2130 punct : ,CAGTCACAAGCAAATTACCAAACACTGCC
R1294 T2142 T2143 nummod 5,CACACCCAGTTTGTGTATGTCTTC
R1295 T2143 T2130 dep CACACCCAGTTTGTGTATGTCTTC,CAGTCACAAGCAAATTACCAAACACTGCC
R1296 T2144 T2142 punct ′,5
R1297 T2145 T2143 punct -,CACACCCAGTTTGTGTATGTCTTC
R1298 T2146 T2143 punct -,CACACCCAGTTTGTGTATGTCTTC
R1299 T2147 T2143 nummod 3,CACACCCAGTTTGTGTATGTCTTC
R1300 T2148 T2143 punct ′,CACACCCAGTTTGTGTATGTCTTC
R1301 T2149 T2130 punct ;,CAGTCACAAGCAAATTACCAAACACTGCC
R1302 T2150 T2130 nummod 5,CAGTCACAAGCAAATTACCAAACACTGCC
R1303 T2151 T2150 punct ′,5
R1304 T2152 T2130 punct -,CAGTCACAAGCAAATTACCAAACACTGCC
R1305 T2153 T2130 punct -,CAGTCACAAGCAAATTACCAAACACTGCC
R1306 T2154 T2130 nummod 3,CAGTCACAAGCAAATTACCAAACACTGCC
R1307 T2155 T2130 punct ′,CAGTCACAAGCAAATTACCAAACACTGCC
R1308 T2156 T2103 punct .,genotyped

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T1969 14-18 PR:000010717 denotes Mtf1
T1970 40-44 NCBITaxon:10088 denotes mice
T1971 49-54 UBERON:0002107 denotes liver
T1972 73-77 PR:000010717 denotes Mtf1
T1973 99-103 NCBITaxon:10088 denotes mice
T1974 182-196 SO:0000040 denotes genomic clones
T1975 208-213 SO:0000147 denotes exons
T1976 224-228 PR:000010717 denotes Mtf1
T1977 254-258 SO:0000704 denotes gene
T1978 259-275 SO:0001644 denotes targeting vector
T1979 329-337 CHEBI:7507 denotes neomycin
T1980 349-357 SO:0005853 denotes cassette
T1981 368-375 SO:0000357 denotes flanked
T1982 383-393 SO:0000346 denotes loxP sites
T1983 430-434 SO:0000147 denotes exon
T1984 440-444 PR:000010717 denotes Mtf1
T1985 456-465 SO:0000346 denotes loxP site
T1986 502-506 SO:0000147 denotes exon
T1987 534-542 SO:0005853 denotes cassette
T1988 579-583 SO:0000147 denotes exon
T1989 591-599 CL:0002322 denotes ES cells
T1990 640-656 SO:0001644 denotes targeting vector
T1991 686-690 CHEBI:42768 denotes G418
T1992 790-800 GO:0010467 denotes expression
T1993 850-858 SO:0005853 denotes cassette
T1994 864-868 NCBITaxon:10088 denotes mice
T1995 891-895 PR:000010717 denotes Mtf1
T1996 895-899 SO:0000346 denotes loxP
T1997 900-906 SO:0001023 denotes allele
T1998 967-978 UBERON:0000358 denotes blastocysts
T1999 1035-1042 NCBITaxon:33208 denotes animals
T2000 1044-1048 PR:000010717 denotes Mtf1
T2001 1048-1052 SO:0000346 denotes loxP
T2002 1053-1057 SO:0000346 denotes loxP
T2003 1113-1115 PR:000010788 denotes Mx
T2004 1177-1182 UBERON:0002107 denotes liver
T2005 1192-1196 PR:000010717 denotes Mtf1
T2006 1216-1220 NCBITaxon:10088 denotes mice
T2007 1263-1270 SO:0000112 denotes primers
T2008 1367-1371 PR:000010717 denotes Mtf1
T2009 1371-1375 SO:0000346 denotes loxP
T2010 1389-1395 SO:0001023 denotes allele

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2011 14-18 PR_EXT:000010717 denotes Mtf1
T2012 40-44 NCBITaxon:10088 denotes mice
T2013 49-54 UBERON:0002107 denotes liver
T2014 64-72 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T2015 73-77 PR_EXT:000010717 denotes Mtf1
T2016 99-103 NCBITaxon:10088 denotes mice
T2017 182-196 SO_EXT:0000040 denotes genomic clones
T2018 208-213 SO_EXT:0000147 denotes exons
T2019 224-228 PR_EXT:000010717 denotes Mtf1
T2020 254-258 SO_EXT:0000704 denotes gene
T2021 259-275 SO_EXT:0001644 denotes targeting vector
T2022 291-304 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T2024 349-357 SO_EXT:0005853 denotes cassette
T2025 359-362 GO_EXT:phosphoglycerate_kinase denotes PGK
T2026 363-366 CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase denotes neo
T2027 368-375 SO:0000357 denotes flanked
T2028 383-393 SO_EXT:0000346 denotes loxP sites
T2029 398-404 SO_EXT:sequence_cloning_process denotes cloned
T2030 430-434 SO_EXT:0000147 denotes exon
T2031 440-444 PR_EXT:000010717 denotes Mtf1
T2032 456-465 SO_EXT:0000346 denotes loxP site
T2033 470-476 SO_EXT:sequence_cloning_process denotes cloned
T2034 502-506 SO_EXT:0000147 denotes exon
T2035 512-521 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymidine
T2036 512-528 GO_PR_EXT:thymidine_kinase denotes thymidine kinase
T2037 530-532 GO_PR_EXT:thymidine_kinase denotes TK
T2038 534-542 SO_EXT:0005853 denotes cassette
T2039 547-555 SO_EXT:sequence_insertion_process denotes inserted
T2040 579-583 SO_EXT:0000147 denotes exon
T2041 591-599 CL:0002322 denotes ES cells
T2042 594-599 CL_GO_EXT:cell denotes cells
T2043 629-639 SO_EXT:sequence_linearization denotes linearized
T2044 640-656 SO_EXT:0001644 denotes targeting vector
T2045 686-690 CHEBI:42768 denotes G418
T2046 790-800 GO:0010467 denotes expression
T2047 808-819 GO_EXT:recombinase denotes recombinase
T2048 842-845 GO_EXT:phosphoglycerate_kinase denotes PGK
T2049 846-849 CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase denotes neo
T2050 850-858 SO_EXT:0005853 denotes cassette
T2051 864-868 NCBITaxon:10088 denotes mice
T2052 882-890 SO_EXT:sequence_alteration_process denotes modified
T2053 891-895 PR_EXT:000010717 denotes Mtf1
T2054 895-899 SO_EXT:0000346 denotes loxP
T2055 900-906 SO_EXT:0001023 denotes allele
T2056 947-953 SO_EXT:sequence_cloned_entity denotes clones
T2057 967-978 UBERON:0000358 denotes blastocysts
T2058 1035-1042 NCBITaxon:33208 denotes animals
T2059 1044-1048 PR_EXT:000010717 denotes Mtf1
T2060 1048-1052 SO_EXT:0000346 denotes loxP
T2061 1053-1057 SO_EXT:0000346 denotes loxP
T2062 1085-1096 GO_EXT:recombinase denotes recombinase
T2063 1097-1107 SO_EXT:transgenic_entity denotes transgenic
T2064 1113-1115 PR_EXT:000010788 denotes Mx
T2065 1177-1182 UBERON:0002107 denotes liver
T2066 1192-1196 PR_EXT:000010717 denotes Mtf1
T2067 1216-1220 NCBITaxon:10088 denotes mice
T2068 1263-1270 SO_EXT:0000112 denotes primers
T2069 1289-1300 GO_EXT:recombinase denotes recombinase
T2070 1367-1371 PR_EXT:000010717 denotes Mtf1
T2071 1371-1375 SO_EXT:0000346 denotes loxP
T2072 1379-1388 SO_EXT:wild_type_entity_or_quality denotes wild-type
T2073 1389-1395 SO_EXT:0001023 denotes allele
T2023 329-337 CHEBI:7507 denotes neomycin