PMC:1253828 / 4487-4991 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T1536","span":{"begin":21,"end":25},"obj":"NNS"},{"id":"T1538","span":{"begin":0,"end":11},"obj":"JJ"},{"id":"T1539","span":{"begin":12,"end":20},"obj":"NN"},{"id":"T1540","span":{"begin":26,"end":29},"obj":"CC"},{"id":"T1541","span":{"begin":30,"end":37},"obj":"NN"},{"id":"T1542","span":{"begin":38,"end":49},"obj":"NNS"},{"id":"T1543","span":{"begin":50,"end":53},"obj":"CC"},{"id":"T1544","span":{"begin":54,"end":61},"obj":"JJ"},{"id":"T1545","span":{"begin":76,"end":85},"obj":"VBN"},{"id":"T1546","span":{"begin":62,"end":64},"obj":"IN"},{"id":"T1547","span":{"begin":65,"end":70},"obj":"DT"},{"id":"T1548","span":{"begin":71,"end":75},"obj":"VBD"},{"id":"T1549","span":{"begin":86,"end":88},"obj":"IN"},{"id":"T1550","span":{"begin":89,"end":105},"obj":"JJ"},{"id":"T1551","span":{"begin":109,"end":112},"obj":"NN"},{"id":"T1552","span":{"begin":106,"end":108},"obj":"NN"},{"id":"T1553","span":{"begin":108,"end":109},"obj":"HYPH"},{"id":"T1554","span":{"begin":112,"end":113},"obj":"."},{"id":"T1555","span":{"begin":113,"end":478},"obj":"sentence"},{"id":"T1556","span":{"begin":114,"end":121},"obj":"IN"},{"id":"T1557","span":{"begin":218,"end":222},"obj":"VBP"},{"id":"T1558","span":{"begin":122,"end":125},"obj":"DT"},{"id":"T1559","span":{"begin":159,"end":164},"obj":"NNS"},{"id":"T1560","span":{"begin":126,"end":132},"obj":"NN"},{"id":"T1561","span":{"begin":133,"end":142},"obj":"JJ"},{"id":"T1562","span":{"begin":132,"end":133},"obj":"HYPH"},{"id":"T1563","span":{"begin":143,"end":158},"obj":"NN"},{"id":"T1564","span":{"begin":165,"end":169},"obj":"WDT"},{"id":"T1565","span":{"begin":183,"end":188},"obj":"VBN"},{"id":"T1566","span":{"begin":170,"end":174},"obj":"VBD"},{"id":"T1567","span":{"begin":175,"end":182},"obj":"RB"},{"id":"T1568","span":{"begin":189,"end":191},"obj":"IN"},{"id":"T1569","span":{"begin":192,"end":198},"obj":"NN"},{"id":"T1570","span":{"begin":199,"end":204},"obj":"NNS"},{"id":"T1571","span":{"begin":205,"end":207},"obj":"IN"},{"id":"T1572","span":{"begin":208,"end":211},"obj":"NN"},{"id":"T1573","span":{"begin":211,"end":212},"obj":"HYPH"},{"id":"T1574","span":{"begin":212,"end":213},"obj":"CD"},{"id":"T1575","span":{"begin":213,"end":215},"obj":","},{"id":"T1576","span":{"begin":215,"end":217},"obj":"PRP"},{"id":"T1577","span":{"begin":223,"end":227},"obj":"IN"},{"id":"T1578","span":{"begin":234,"end":236},"obj":"VBZ"},{"id":"T1579","span":{"begin":228,"end":231},"obj":"NN"},{"id":"T1580","span":{"begin":231,"end":232},"obj":"HYPH"},{"id":"T1581","span":{"begin":232,"end":233},"obj":"CD"},{"id":"T1582","span":{"begin":237,"end":246},"obj":"JJ"},{"id":"T1583","span":{"begin":247,"end":250},"obj":"IN"},{"id":"T1584","span":{"begin":251,"end":256},"obj":"JJ"},{"id":"T1585","span":{"begin":263,"end":273},"obj":"NN"},{"id":"T1586","span":{"begin":257,"end":262},"obj":"NN"},{"id":"T1587","span":{"begin":274,"end":276},"obj":"IN"},{"id":"T1588","span":{"begin":277,"end":280},"obj":"DT"},{"id":"T1589","span":{"begin":281,"end":285},"obj":"NN"},{"id":"T1590","span":{"begin":286,"end":289},"obj":"IN"},{"id":"T1591","span":{"begin":290,"end":303},"obj":"NN"},{"id":"T1592","span":{"begin":307,"end":313},"obj":"NN"},{"id":"T1593","span":{"begin":304,"end":305},"obj":"NN"},{"id":"T1594","span":{"begin":305,"end":307},"obj":","},{"id":"T1595","span":{"begin":314,"end":315},"obj":"CD"},{"id":"T1596","span":{"begin":316,"end":317},"obj":"-LRB-"},{"id":"T1597","span":{"begin":317,"end":322},"obj":"NN"},{"id":"T1598","span":{"begin":322,"end":323},"obj":"-RRB-"},{"id":"T1599","span":{"begin":324,"end":326},"obj":"RB"},{"id":"T1600","span":{"begin":332,"end":334},"obj":"IN"},{"id":"T1601","span":{"begin":327,"end":331},"obj":"RB"},{"id":"T1602","span":{"begin":335,"end":338},"obj":"IN"},{"id":"T1603","span":{"begin":339,"end":346},"obj":"NN"},{"id":"T1604","span":{"begin":347,"end":354},"obj":"VBN"},{"id":"T1605","span":{"begin":346,"end":347},"obj":"HYPH"},{"id":"T1606","span":{"begin":355,"end":365},"obj":"NN"},{"id":"T1607","span":{"begin":366,"end":368},"obj":"IN"},{"id":"T1608","span":{"begin":369,"end":370},"obj":"NN"},{"id":"T1609","span":{"begin":371,"end":374},"obj":"NN"},{"id":"T1610","span":{"begin":370,"end":371},"obj":"HYPH"},{"id":"T1611","span":{"begin":396,"end":400},"obj":"NN"},{"id":"T1612","span":{"begin":375,"end":385},"obj":"RB"},{"id":"T1613","span":{"begin":386,"end":395},"obj":"VBN"},{"id":"T1614","span":{"begin":401,"end":402},"obj":"CD"},{"id":"T1615","span":{"begin":403,"end":404},"obj":"-LRB-"},{"id":"T1616","span":{"begin":404,"end":409},"obj":"NN"},{"id":"T1617","span":{"begin":409,"end":410},"obj":"-RRB-"},{"id":"T1618","span":{"begin":411,"end":414},"obj":"CC"},{"id":"T1619","span":{"begin":415,"end":418},"obj":"DT"},{"id":"T1620","span":{"begin":419,"end":423},"obj":"NN"},{"id":"T1621","span":{"begin":424,"end":432},"obj":"VBG"},{"id":"T1622","span":{"begin":433,"end":441},"obj":"NN"},{"id":"T1623","span":{"begin":455,"end":459},"obj":"JJ"},{"id":"T1624","span":{"begin":441,"end":442},"obj":"HYPH"},{"id":"T1625","span":{"begin":443,"end":446},"obj":"CC"},{"id":"T1626","span":{"begin":447,"end":454},"obj":"NN"},{"id":"T1627","span":{"begin":454,"end":455},"obj":"HYPH"},{"id":"T1628","span":{"begin":460,"end":467},"obj":"NN"},{"id":"T1629","span":{"begin":468,"end":469},"obj":"CD"},{"id":"T1630","span":{"begin":470,"end":471},"obj":"-LRB-"},{"id":"T1631","span":{"begin":471,"end":476},"obj":"NN"},{"id":"T1632","span":{"begin":476,"end":477},"obj":"-RRB-"},{"id":"T1633","span":{"begin":477,"end":478},"obj":"."},{"id":"T1635","span":{"begin":479,"end":481},"obj":"IN"},{"id":"T1637","span":{"begin":482,"end":490},"obj":"NN"},{"id":"T1638","span":{"begin":490,"end":492},"obj":","},{"id":"T1639","span":{"begin":492,"end":495},"obj":"NN"},{"id":"T1640","span":{"begin":495,"end":496},"obj":"HYPH"},{"id":"T1641","span":{"begin":496,"end":497},"obj":"CD"}],"relations":[{"id":"R864","pred":"amod","subj":"T1538","obj":"T1539"},{"id":"R865","pred":"compound","subj":"T1539","obj":"T1536"},{"id":"R866","pred":"cc","subj":"T1540","obj":"T1536"},{"id":"R867","pred":"compound","subj":"T1541","obj":"T1542"},{"id":"R868","pred":"conj","subj":"T1542","obj":"T1536"},{"id":"R870","pred":"nsubjpass","subj":"T1544","obj":"T1545"},{"id":"R872","pred":"prep","subj":"T1546","obj":"T1544"},{"id":"R873","pred":"pobj","subj":"T1547","obj":"T1546"},{"id":"R874","pred":"auxpass","subj":"T1548","obj":"T1545"},{"id":"R875","pred":"agent","subj":"T1549","obj":"T1545"},{"id":"R876","pred":"amod","subj":"T1550","obj":"T1551"},{"id":"R877","pred":"pobj","subj":"T1551","obj":"T1549"},{"id":"R878","pred":"compound","subj":"T1552","obj":"T1551"},{"id":"R879","pred":"punct","subj":"T1553","obj":"T1551"},{"id":"R880","pred":"punct","subj":"T1554","obj":"T1545"},{"id":"R881","pred":"prep","subj":"T1556","obj":"T1557"},{"id":"R882","pred":"det","subj":"T1558","obj":"T1559"},{"id":"R883","pred":"pobj","subj":"T1559","obj":"T1556"},{"id":"R884","pred":"npadvmod","subj":"T1560","obj":"T1561"},{"id":"R885","pred":"amod","subj":"T1561","obj":"T1559"},{"id":"R886","pred":"punct","subj":"T1562","obj":"T1561"},{"id":"R887","pred":"compound","subj":"T1563","obj":"T1559"},{"id":"R888","pred":"dep","subj":"T1564","obj":"T1565"},{"id":"R889","pred":"relcl","subj":"T1565","obj":"T1559"},{"id":"R890","pred":"auxpass","subj":"T1566","obj":"T1565"},{"id":"R891","pred":"advmod","subj":"T1567","obj":"T1565"},{"id":"R892","pred":"prep","subj":"T1568","obj":"T1565"},{"id":"R893","pred":"compound","subj":"T1569","obj":"T1570"},{"id":"R894","pred":"pobj","subj":"T1570","obj":"T1568"},{"id":"R895","pred":"prep","subj":"T1571","obj":"T1570"},{"id":"R896","pred":"pobj","subj":"T1572","obj":"T1571"},{"id":"R897","pred":"punct","subj":"T1573","obj":"T1572"},{"id":"R898","pred":"nummod","subj":"T1574","obj":"T1572"},{"id":"R899","pred":"punct","subj":"T1575","obj":"T1557"},{"id":"R900","pred":"nsubj","subj":"T1576","obj":"T1557"},{"id":"R901","pred":"mark","subj":"T1577","obj":"T1578"},{"id":"R902","pred":"ccomp","subj":"T1578","obj":"T1557"},{"id":"R903","pred":"nsubj","subj":"T1579","obj":"T1578"},{"id":"R904","pred":"punct","subj":"T1580","obj":"T1579"},{"id":"R905","pred":"nummod","subj":"T1581","obj":"T1579"},{"id":"R906","pred":"acomp","subj":"T1582","obj":"T1578"},{"id":"R907","pred":"prep","subj":"T1583","obj":"T1582"},{"id":"R908","pred":"amod","subj":"T1584","obj":"T1585"},{"id":"R909","pred":"pobj","subj":"T1585","obj":"T1583"},{"id":"R910","pred":"compound","subj":"T1586","obj":"T1585"},{"id":"R911","pred":"prep","subj":"T1587","obj":"T1585"},{"id":"R912","pred":"det","subj":"T1588","obj":"T1589"},{"id":"R913","pred":"pobj","subj":"T1589","obj":"T1587"},{"id":"R914","pred":"prep","subj":"T1590","obj":"T1589"},{"id":"R915","pred":"nmod","subj":"T1591","obj":"T1592"},{"id":"R916","pred":"pobj","subj":"T1592","obj":"T1590"},{"id":"R917","pred":"nmod","subj":"T1593","obj":"T1592"},{"id":"R918","pred":"punct","subj":"T1594","obj":"T1592"},{"id":"R919","pred":"nummod","subj":"T1595","obj":"T1592"},{"id":"R920","pred":"punct","subj":"T1596","obj":"T1592"},{"id":"R921","pred":"appos","subj":"T1597","obj":"T1592"},{"id":"R922","pred":"punct","subj":"T1598","obj":"T1590"},{"id":"R923","pred":"advmod","subj":"T1599","obj":"T1600"},{"id":"R924","pred":"cc","subj":"T1600","obj":"T1590"},{"id":"R925","pred":"advmod","subj":"T1601","obj":"T1600"},{"id":"R926","pred":"conj","subj":"T1602","obj":"T1590"},{"id":"R927","pred":"npadvmod","subj":"T1603","obj":"T1604"},{"id":"R928","pred":"amod","subj":"T1604","obj":"T1606"},{"id":"R929","pred":"punct","subj":"T1605","obj":"T1604"},{"id":"R930","pred":"pobj","subj":"T1606","obj":"T1602"},{"id":"R931","pred":"prep","subj":"T1607","obj":"T1606"},{"id":"R932","pred":"nmod","subj":"T1608","obj":"T1609"},{"id":"R933","pred":"nmod","subj":"T1609","obj":"T1611"},{"id":"R934","pred":"punct","subj":"T1610","obj":"T1609"},{"id":"R935","pred":"pobj","subj":"T1611","obj":"T1607"},{"id":"R936","pred":"advmod","subj":"T1612","obj":"T1613"},{"id":"R937","pred":"amod","subj":"T1613","obj":"T1611"},{"id":"R938","pred":"nummod","subj":"T1614","obj":"T1611"},{"id":"R939","pred":"punct","subj":"T1615","obj":"T1611"},{"id":"R940","pred":"appos","subj":"T1616","obj":"T1611"},{"id":"R941","pred":"punct","subj":"T1617","obj":"T1611"},{"id":"R942","pred":"cc","subj":"T1618","obj":"T1611"},{"id":"R943","pred":"det","subj":"T1619","obj":"T1620"},{"id":"R944","pred":"conj","subj":"T1620","obj":"T1611"},{"id":"R945","pred":"acl","subj":"T1621","obj":"T1620"},{"id":"R946","pred":"npadvmod","subj":"T1622","obj":"T1623"},{"id":"R947","pred":"amod","subj":"T1623","obj":"T1628"},{"id":"R948","pred":"punct","subj":"T1624","obj":"T1622"},{"id":"R949","pred":"cc","subj":"T1625","obj":"T1622"},{"id":"R950","pred":"conj","subj":"T1626","obj":"T1622"},{"id":"R951","pred":"punct","subj":"T1627","obj":"T1623"},{"id":"R952","pred":"dobj","subj":"T1628","obj":"T1621"},{"id":"R953","pred":"nummod","subj":"T1629","obj":"T1628"},{"id":"R954","pred":"punct","subj":"T1630","obj":"T1628"},{"id":"R955","pred":"appos","subj":"T1631","obj":"T1628"},{"id":"R956","pred":"punct","subj":"T1632","obj":"T1557"},{"id":"R957","pred":"punct","subj":"T1633","obj":"T1557"},{"id":"R959","pred":"pobj","subj":"T1637","obj":"T1635"},{"id":"R962","pred":"punct","subj":"T1640","obj":"T1639"},{"id":"R963","pred":"nummod","subj":"T1641","obj":"T1639"}],"text":"conditional knockout mice and control littermates and several of these were confirmed by semiquantitative RT–PCR. Besides the stress-inducible metallothionein genes that were already known as target genes of MTF-1, we find that MTF-1 is important for basal liver expression of the gene for selenoprotein W, muscle 1 (Sepw1) as well as for cadmium-induced expression of N-myc downstream regulated gene 1 (Ndrg1) and the gene encoding cysteine- and glycine-rich protein 1 (Csrp1). In addition, MTF-1 appear"}

{"project":"craft-ca-core-dev","denotations":[{"id":"T783","span":{"begin":21,"end":25},"obj":"NCBITaxon:10088"},{"id":"T784","span":{"begin":159,"end":164},"obj":"SO:0000704"},{"id":"T785","span":{"begin":199,"end":204},"obj":"SO:0000704"},{"id":"T786","span":{"begin":208,"end":213},"obj":"PR:000010717"},{"id":"T787","span":{"begin":228,"end":233},"obj":"PR:000010717"},{"id":"T788","span":{"begin":257,"end":262},"obj":"UBERON:0002107"},{"id":"T789","span":{"begin":263,"end":273},"obj":"GO:0010467"},{"id":"T790","span":{"begin":281,"end":285},"obj":"SO:0000704"},{"id":"T791","span":{"begin":290,"end":315},"obj":"PR:000014662"},{"id":"T792","span":{"begin":317,"end":322},"obj":"PR:000014662"},{"id":"T793","span":{"begin":355,"end":365},"obj":"GO:0010467"},{"id":"T794","span":{"begin":369,"end":402},"obj":"PR:000011059"},{"id":"T795","span":{"begin":386,"end":395},"obj":"GO:0065007"},{"id":"T796","span":{"begin":396,"end":400},"obj":"SO:0000704"},{"id":"T797","span":{"begin":404,"end":409},"obj":"PR:000011059"},{"id":"T798","span":{"begin":419,"end":423},"obj":"SO:0000704"},{"id":"T799","span":{"begin":433,"end":469},"obj":"PR:000005958"},{"id":"T800","span":{"begin":471,"end":476},"obj":"PR:000005958"},{"id":"T801","span":{"begin":492,"end":497},"obj":"PR:000010717"}],"text":"conditional knockout mice and control littermates and several of these were confirmed by semiquantitative RT–PCR. Besides the stress-inducible metallothionein genes that were already known as target genes of MTF-1, we find that MTF-1 is important for basal liver expression of the gene for selenoprotein W, muscle 1 (Sepw1) as well as for cadmium-induced expression of N-myc downstream regulated gene 1 (Ndrg1) and the gene encoding cysteine- and glycine-rich protein 1 (Csrp1). In addition, MTF-1 appear"}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T933","span":{"begin":21,"end":25},"obj":"NCBITaxon:10088"},{"id":"T934","span":{"begin":106,"end":108},"obj":"GO_EXT:reverse_transcription_or_reverse_transcriptase"},{"id":"T935","span":{"begin":159,"end":164},"obj":"SO_EXT:0000704"},{"id":"T936","span":{"begin":199,"end":204},"obj":"SO_EXT:0000704"},{"id":"T937","span":{"begin":208,"end":213},"obj":"PR_EXT:000010717"},{"id":"T938","span":{"begin":228,"end":233},"obj":"PR_EXT:000010717"},{"id":"T939","span":{"begin":257,"end":262},"obj":"UBERON:0002107"},{"id":"T940","span":{"begin":263,"end":273},"obj":"GO:0010467"},{"id":"T941","span":{"begin":281,"end":285},"obj":"SO_EXT:0000704"},{"id":"T942","span":{"begin":290,"end":303},"obj":"CHEBI_EXT:selenoprotein"},{"id":"T943","span":{"begin":290,"end":315},"obj":"PR_EXT:000014662"},{"id":"T944","span":{"begin":307,"end":313},"obj":"UBERON_EXT:muscle_structure_or_tissue"},{"id":"T945","span":{"begin":317,"end":322},"obj":"PR_EXT:000014662"},{"id":"T946","span":{"begin":339,"end":346},"obj":"CHEBI_EXT:cadmium"},{"id":"T947","span":{"begin":355,"end":365},"obj":"GO:0010467"},{"id":"T948","span":{"begin":369,"end":402},"obj":"PR_EXT:000011059"},{"id":"T949","span":{"begin":386,"end":395},"obj":"GO:0065007"},{"id":"T950","span":{"begin":396,"end":400},"obj":"SO_EXT:0000704"},{"id":"T951","span":{"begin":404,"end":409},"obj":"PR_EXT:000011059"},{"id":"T952","span":{"begin":419,"end":423},"obj":"SO_EXT:0000704"},{"id":"T953","span":{"begin":424,"end":432},"obj":"SO_EXT:sequence_coding_function"},{"id":"T954","span":{"begin":433,"end":441},"obj":"CHEBI_SO_EXT:cysteine"},{"id":"T955","span":{"begin":433,"end":469},"obj":"PR_EXT:000005958"},{"id":"T956","span":{"begin":447,"end":454},"obj":"CHEBI_SO_EXT:glycine"},{"id":"T957","span":{"begin":460,"end":467},"obj":"CHEBI_PR_EXT:protein"},{"id":"T958","span":{"begin":471,"end":476},"obj":"PR_EXT:000005958"},{"id":"T959","span":{"begin":492,"end":497},"obj":"PR_EXT:000010717"}],"text":"conditional knockout mice and control littermates and several of these were confirmed by semiquantitative RT–PCR. Besides the stress-inducible metallothionein genes that were already known as target genes of MTF-1, we find that MTF-1 is important for basal liver expression of the gene for selenoprotein W, muscle 1 (Sepw1) as well as for cadmium-induced expression of N-myc downstream regulated gene 1 (Ndrg1) and the gene encoding cysteine- and glycine-rich protein 1 (Csrp1). In addition, MTF-1 appear"}