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Id Subject Object Predicate Lexical cue
T8110 0-7 NN denotes Cadmium
T8111 8-18 JJ denotes responsive
T8112 7-8 HYPH denotes -
T8113 38-43 NNS denotes genes
T8114 18-20 , denotes ,
T8115 20-23 NN denotes MTF
T8116 26-37 JJ denotes independent
T8117 23-24 HYPH denotes -
T8118 24-25 CD denotes 1
T8119 25-26 HYPH denotes -
T8120 43-291 sentence denotes Finally, we also identified a number of cadmium-responsive genes that were independent of MTF-1 presence, by comparing the probe array data of all cadmium-treated mice with the data of all mock-treated mice, irrespective of the genotype (Table 2).
T8121 44-51 RB denotes Finally
T8122 61-71 VBD denotes identified
T8123 51-53 , denotes ,
T8124 53-55 PRP denotes we
T8125 56-60 RB denotes also
T8126 72-73 DT denotes a
T8127 74-80 NN denotes number
T8128 81-83 IN denotes of
T8129 84-91 NN denotes cadmium
T8130 92-102 JJ denotes responsive
T8131 91-92 HYPH denotes -
T8132 103-108 NNS denotes genes
T8133 109-113 WDT denotes that
T8134 114-118 VBD denotes were
T8135 119-130 JJ denotes independent
T8136 131-133 IN denotes of
T8137 134-137 NN denotes MTF
T8138 140-148 NN denotes presence
T8139 137-138 HYPH denotes -
T8140 138-139 CD denotes 1
T8141 148-150 , denotes ,
T8142 150-152 IN denotes by
T8143 153-162 VBG denotes comparing
T8144 163-166 DT denotes the
T8145 179-183 NNS denotes data
T8146 167-172 NN denotes probe
T8147 173-178 NN denotes array
T8148 184-186 IN denotes of
T8149 187-190 DT denotes all
T8150 207-211 NNS denotes mice
T8151 191-198 NN denotes cadmium
T8152 199-206 VBN denotes treated
T8153 198-199 HYPH denotes -
T8154 212-216 IN denotes with
T8155 217-220 DT denotes the
T8156 221-225 NNS denotes data
T8157 226-228 IN denotes of
T8158 229-232 DT denotes all
T8159 246-250 NNS denotes mice
T8160 233-237 JJ denotes mock
T8161 238-245 VBN denotes treated
T8162 237-238 HYPH denotes -
T8163 250-252 , denotes ,
T8164 252-264 RB denotes irrespective
T8165 265-267 IN denotes of
T8166 268-271 DT denotes the
T8167 272-280 NN denotes genotype
T8168 281-282 -LRB- denotes (
T8169 282-287 NN denotes Table
T8170 288-289 CD denotes 2
T8171 289-290 -RRB- denotes )
T8172 290-291 . denotes .
T8173 291-451 sentence denotes An at least 2-fold, reliable upregulation was observed after cadmium exposure for 31 probe sets corresponding to 21 different characterized genes (Table 2, a).
T8174 292-294 DT denotes An
T8175 321-333 NN denotes upregulation
T8176 295-297 RB denotes at
T8177 298-303 RBS denotes least
T8178 304-310 JJ denotes 2-fold
T8179 310-312 , denotes ,
T8180 312-320 JJ denotes reliable
T8181 338-346 VBN denotes observed
T8182 334-337 VBD denotes was
T8183 347-352 IN denotes after
T8184 353-360 NN denotes cadmium
T8185 361-369 NN denotes exposure
T8186 370-373 IN denotes for
T8187 374-376 CD denotes 31
T8188 383-387 NNS denotes sets
T8189 377-382 NN denotes probe
T8190 388-401 VBG denotes corresponding
T8191 402-404 IN denotes to
T8192 405-407 CD denotes 21
T8193 432-437 NNS denotes genes
T8194 408-417 JJ denotes different
T8195 418-431 VBN denotes characterized
T8196 438-439 -LRB- denotes (
T8197 448-449 NN denotes a
T8198 439-444 NN denotes Table
T8199 445-446 CD denotes 2
T8200 446-448 , denotes ,
T8201 449-450 -RRB- denotes )
T8202 450-451 . denotes .
T8203 451-569 sentence denotes For 2 probe sets corresponding to 2 characterized genes, an at least 2-fold downregulation was detected (Table 2, b).
T8204 452-455 IN denotes For
T8205 547-555 VBN denotes detected
T8206 456-457 CD denotes 2
T8207 464-468 NNS denotes sets
T8208 458-463 NN denotes probe
T8209 469-482 VBG denotes corresponding
T8210 483-485 IN denotes to
T8211 486-487 CD denotes 2
T8212 502-507 NNS denotes genes
T8213 488-501 VBN denotes characterized
T8214 507-509 , denotes ,
T8215 509-511 DT denotes an
T8216 528-542 NN denotes downregulation
T8217 512-514 RB denotes at
T8218 515-520 RBS denotes least
T8219 521-527 JJ denotes 2-fold
T8220 543-546 VBD denotes was
T8221 556-557 -LRB- denotes (
T8222 566-567 NN denotes b
T8223 557-562 NN denotes Table
T8224 563-564 CD denotes 2
T8225 564-566 , denotes ,
T8226 567-568 -RRB- denotes )
T8227 568-569 . denotes .
T8228 569-1077 sentence denotes Several genes involved in the metabolism of the antioxidant glutathione were found to be upregulated by cadmium exposure, namely the genes encoding the catalytic subunit of glutamate-cysteine ligase (Gclc) that is the rate limiting enzyme in de novo synthesis of glutathione (45); glutathione reductase 1 (Gsr), the reducing enzyme for oxidized glutathione (45); and glutathione-S-transferase, mu 4 (Gstm4), which is a member of the glutathione-S-transferase supergene family of detoxification enzymes (45).
T8229 570-577 JJ denotes Several
T8230 578-583 NNS denotes genes
T8231 647-652 VBN denotes found
T8232 584-592 VBN denotes involved
T8233 593-595 IN denotes in
T8234 596-599 DT denotes the
T8235 600-610 NN denotes metabolism
T8236 611-613 IN denotes of
T8237 614-617 DT denotes the
T8238 630-641 NN denotes glutathione
T8239 618-629 NN denotes antioxidant
T8240 642-646 VBD denotes were
T8241 653-655 TO denotes to
T8242 659-670 VBN denotes upregulated
T8243 656-658 VB denotes be
T8244 671-673 IN denotes by
T8245 674-681 NN denotes cadmium
T8246 682-690 NN denotes exposure
T8247 690-692 , denotes ,
T8248 692-698 RB denotes namely
T8249 703-708 NNS denotes genes
T8250 699-702 DT denotes the
T8251 709-717 VBG denotes encoding
T8252 718-721 DT denotes the
T8253 732-739 NN denotes subunit
T8254 722-731 JJ denotes catalytic
T8255 740-742 IN denotes of
T8256 743-752 NN denotes glutamate
T8257 762-768 NN denotes ligase
T8258 752-753 HYPH denotes -
T8259 753-761 NN denotes cysteine
T8260 769-770 -LRB- denotes (
T8261 770-774 NN denotes Gclc
T8262 774-775 -RRB- denotes )
T8263 776-780 WDT denotes that
T8264 781-783 VBZ denotes is
T8265 784-787 DT denotes the
T8266 802-808 NN denotes enzyme
T8267 788-792 NN denotes rate
T8268 793-801 VBG denotes limiting
T8269 809-811 IN denotes in
T8270 812-814 FW denotes de
T8271 815-819 FW denotes novo
T8272 820-829 NN denotes synthesis
T8273 830-832 IN denotes of
T8274 833-844 NN denotes glutathione
T8275 845-846 -LRB- denotes (
T8276 846-848 CD denotes 45
T8277 848-849 -RRB- denotes )
T8278 849-850 : denotes ;
T8279 851-862 NN denotes glutathione
T8280 863-872 NN denotes reductase
T8281 873-874 CD denotes 1
T8282 875-876 -LRB- denotes (
T8283 876-879 NN denotes Gsr
T8284 879-880 -RRB- denotes )
T8285 880-882 , denotes ,
T8286 882-885 DT denotes the
T8287 895-901 NN denotes enzyme
T8288 886-894 VBG denotes reducing
T8289 902-905 IN denotes for
T8290 906-914 VBN denotes oxidized
T8291 915-926 NN denotes glutathione
T8292 927-928 -LRB- denotes (
T8293 928-930 CD denotes 45
T8294 930-931 -RRB- denotes )
T8295 931-932 : denotes ;
T8296 933-936 CC denotes and
T8297 937-948 NN denotes glutathione
T8298 951-962 NN denotes transferase
T8299 948-949 HYPH denotes -
T8300 949-950 NN denotes S
T8301 950-951 HYPH denotes -
T8302 962-964 , denotes ,
T8303 964-966 NN denotes mu
T8304 970-975 NN denotes Gstm4
T8305 967-968 CD denotes 4
T8306 969-970 -LRB- denotes (
T8307 975-976 -RRB- denotes )
T8308 976-978 , denotes ,
T8309 978-983 WDT denotes which
T8310 984-986 VBZ denotes is
T8311 987-988 DT denotes a
T8312 989-995 NN denotes member
T8313 996-998 IN denotes of
T8314 999-1002 DT denotes the
T8315 1039-1045 NN denotes family
T8316 1003-1014 NN denotes glutathione
T8317 1017-1028 NN denotes transferase
T8318 1014-1015 HYPH denotes -
T8319 1015-1016 NN denotes S
T8320 1016-1017 HYPH denotes -
T8321 1029-1038 NN denotes supergene
T8322 1046-1048 IN denotes of
T8323 1049-1063 NN denotes detoxification
T8324 1064-1071 NNS denotes enzymes
T8325 1072-1073 -LRB- denotes (
T8326 1073-1075 CD denotes 45
T8327 1075-1076 -RRB- denotes )
T8328 1076-1077 . denotes .
T8329 1077-1170 sentence denotes In all of these cases, induction was confirmed by semiquantitative RT–PCRs (data not shown).
T8330 1078-1080 IN denotes In
T8331 1115-1124 VBN denotes confirmed
T8332 1081-1084 DT denotes all
T8333 1085-1087 IN denotes of
T8334 1088-1093 DT denotes these
T8335 1094-1099 NNS denotes cases
T8336 1099-1101 , denotes ,
T8337 1101-1110 NN denotes induction
T8338 1111-1114 VBD denotes was
T8339 1125-1127 IN denotes by
T8340 1128-1144 JJ denotes semiquantitative
T8341 1148-1152 NNS denotes PCRs
T8342 1145-1147 NN denotes RT
T8343 1147-1148 HYPH denotes –
T8344 1153-1154 -LRB- denotes (
T8345 1163-1168 VBN denotes shown
T8346 1154-1158 NNS denotes data
T8347 1159-1162 RB denotes not
T8348 1168-1169 -RRB- denotes )
T8349 1169-1170 . denotes .
T8350 1170-1325 sentence denotes Gclc, also referred to as heavy chain subunit of gamma-glutamylcysteine synthetase (Ggcs-hc), had been discussed previously as a target gene of MTF-1 (6).
T8351 1171-1175 NN denotes Gclc
T8352 1274-1283 VBN denotes discussed
T8353 1175-1177 , denotes ,
T8354 1177-1181 RB denotes also
T8355 1182-1190 VBN denotes referred
T8356 1191-1193 IN denotes to
T8357 1194-1196 IN denotes as
T8358 1197-1202 JJ denotes heavy
T8359 1203-1208 NN denotes chain
T8360 1209-1216 NN denotes subunit
T8361 1217-1219 IN denotes of
T8362 1220-1225 NN denotes gamma
T8363 1226-1242 NN denotes glutamylcysteine
T8364 1225-1226 HYPH denotes -
T8365 1243-1253 NN denotes synthetase
T8366 1254-1255 -LRB- denotes (
T8367 1255-1259 NN denotes Ggcs
T8368 1260-1262 NN denotes hc
T8369 1259-1260 HYPH denotes -
T8370 1262-1263 -RRB- denotes )
T8371 1263-1265 , denotes ,
T8372 1265-1268 VBD denotes had
T8373 1269-1273 VBN denotes been
T8374 1284-1294 RB denotes previously
T8375 1295-1297 IN denotes as
T8376 1298-1299 DT denotes a
T8377 1307-1311 NN denotes gene
T8378 1300-1306 NN denotes target
T8379 1312-1314 IN denotes of
T8380 1315-1318 NN denotes MTF
T8381 1318-1319 HYPH denotes -
T8382 1319-1320 CD denotes 1
T8383 1321-1322 -LRB- denotes (
T8384 1322-1323 CD denotes 6
T8385 1323-1324 -RRB- denotes )
T8386 1324-1325 . denotes .
T8387 1325-1450 sentence denotes Our expression data indicate that Gclc is induced by cadmium but, at least in the adult mouse liver, not dependent on MTF-1.
T8388 1326-1329 PRP$ denotes Our
T8389 1341-1345 NNS denotes data
T8390 1330-1340 NN denotes expression
T8391 1346-1354 VBP denotes indicate
T8392 1355-1359 IN denotes that
T8393 1368-1375 VBN denotes induced
T8394 1360-1364 NN denotes Gclc
T8395 1365-1367 VBZ denotes is
T8396 1376-1378 IN denotes by
T8397 1379-1386 NN denotes cadmium
T8398 1387-1390 CC denotes but
T8399 1390-1392 , denotes ,
T8400 1392-1394 RB denotes at
T8401 1395-1400 RBS denotes least
T8402 1401-1403 IN denotes in
T8403 1431-1440 JJ denotes dependent
T8404 1404-1407 DT denotes the
T8405 1420-1425 NN denotes liver
T8406 1408-1413 JJ denotes adult
T8407 1414-1419 NN denotes mouse
T8408 1425-1427 , denotes ,
T8409 1427-1430 RB denotes not
T8410 1441-1443 IN denotes on
T8411 1444-1447 NN denotes MTF
T8412 1447-1448 HYPH denotes -
T8413 1448-1449 CD denotes 1
T8414 1449-1450 . denotes .
T8415 1450-1800 sentence denotes To analyze the role of the glutathione system in the cellular cadmium response, mouse embryonic fibroblasts with and without functional Mtf1 were treated with cadmium in combination with BSO, a specific inhibitor of glutamate-cysteine ligase (31), and cell viability was assessed by a colorimetric assay based on the tetrazolium salt MTT (Figure 6).
T8416 1451-1453 TO denotes To
T8417 1454-1461 VB denotes analyze
T8418 1597-1604 VBN denotes treated
T8419 1462-1465 DT denotes the
T8420 1466-1470 NN denotes role
T8421 1471-1473 IN denotes of
T8422 1474-1477 DT denotes the
T8423 1490-1496 NN denotes system
T8424 1478-1489 NN denotes glutathione
T8425 1497-1499 IN denotes in
T8426 1500-1503 DT denotes the
T8427 1521-1529 NN denotes response
T8428 1504-1512 JJ denotes cellular
T8429 1513-1520 NN denotes cadmium
T8430 1529-1531 , denotes ,
T8431 1531-1536 NN denotes mouse
T8432 1547-1558 NNS denotes fibroblasts
T8433 1537-1546 JJ denotes embryonic
T8434 1559-1563 IN denotes with
T8435 1564-1567 CC denotes and
T8436 1568-1575 IN denotes without
T8437 1576-1586 JJ denotes functional
T8438 1587-1591 NN denotes Mtf1
T8439 1592-1596 VBD denotes were
T8440 1605-1609 IN denotes with
T8441 1610-1617 NN denotes cadmium
T8442 1618-1620 IN denotes in
T8443 1621-1632 NN denotes combination
T8444 1633-1637 IN denotes with
T8445 1638-1641 NN denotes BSO
T8446 1641-1643 , denotes ,
T8447 1643-1644 DT denotes a
T8448 1654-1663 NN denotes inhibitor
T8449 1645-1653 JJ denotes specific
T8450 1664-1666 IN denotes of
T8451 1667-1676 NN denotes glutamate
T8452 1677-1685 NN denotes cysteine
T8453 1676-1677 HYPH denotes -
T8454 1686-1692 NN denotes ligase
T8455 1693-1694 -LRB- denotes (
T8456 1694-1696 CD denotes 31
T8457 1696-1697 -RRB- denotes )
T8458 1697-1699 , denotes ,
T8459 1699-1702 CC denotes and
T8460 1703-1707 NN denotes cell
T8461 1708-1717 NN denotes viability
T8462 1722-1730 VBN denotes assessed
T8463 1718-1721 VBD denotes was
T8464 1731-1733 IN denotes by
T8465 1734-1735 DT denotes a
T8466 1749-1754 NN denotes assay
T8467 1736-1748 JJ denotes colorimetric
T8468 1755-1760 VBN denotes based
T8469 1761-1763 IN denotes on
T8470 1764-1767 DT denotes the
T8471 1780-1784 NN denotes salt
T8472 1768-1779 NN denotes tetrazolium
T8473 1785-1788 NN denotes MTT
T8474 1789-1790 -LRB- denotes (
T8475 1790-1796 NN denotes Figure
T8476 1797-1798 CD denotes 6
T8477 1798-1799 -RRB- denotes )
T8478 1799-1800 . denotes .
T8479 1800-1909 sentence denotes Increasing concentrations of BSO or cadmium alone were to some extent cytotoxic for the examined cell lines.
T8480 1801-1811 VBG denotes Increasing
T8481 1812-1826 NNS denotes concentrations
T8482 1851-1855 VBD denotes were
T8483 1827-1829 IN denotes of
T8484 1830-1833 NN denotes BSO
T8485 1834-1836 CC denotes or
T8486 1837-1844 NN denotes cadmium
T8487 1845-1850 RB denotes alone
T8488 1856-1858 IN denotes to
T8489 1859-1863 DT denotes some
T8490 1864-1870 NN denotes extent
T8491 1871-1880 JJ denotes cytotoxic
T8492 1881-1884 IN denotes for
T8493 1885-1888 DT denotes the
T8494 1903-1908 NNS denotes lines
T8495 1889-1897 VBN denotes examined
T8496 1898-1902 NN denotes cell
T8497 1908-1909 . denotes .
T8498 1909-2145 sentence denotes Treatment with both BSO and cadmium resulted in an enhanced lethality particularly for the cells without functional Mtf1, indicating that a depletion of glutathione together with a lack of Mtf1 impair an efficient anti-cadmium defense.
T8499 1910-1919 NN denotes Treatment
T8500 1946-1954 VBD denotes resulted
T8501 1920-1924 IN denotes with
T8502 1925-1929 CC denotes both
T8503 1930-1933 NN denotes BSO
T8504 1934-1937 CC denotes and
T8505 1938-1945 NN denotes cadmium
T8506 1955-1957 IN denotes in
T8507 1958-1960 DT denotes an
T8508 1970-1979 NN denotes lethality
T8509 1961-1969 VBN denotes enhanced
T8510 1980-1992 RB denotes particularly
T8511 1993-1996 IN denotes for
T8512 1997-2000 DT denotes the
T8513 2001-2006 NNS denotes cells
T8514 2007-2014 IN denotes without
T8515 2015-2025 JJ denotes functional
T8516 2026-2030 NN denotes Mtf1
T8517 2030-2032 , denotes ,
T8518 2032-2042 VBG denotes indicating
T8519 2043-2047 IN denotes that
T8520 2104-2110 VBP denotes impair
T8521 2048-2049 DT denotes a
T8522 2050-2059 NN denotes depletion
T8523 2060-2062 IN denotes of
T8524 2063-2074 NN denotes glutathione
T8525 2075-2083 RB denotes together
T8526 2084-2088 IN denotes with
T8527 2089-2090 DT denotes a
T8528 2091-2095 NN denotes lack
T8529 2096-2098 IN denotes of
T8530 2099-2103 NN denotes Mtf1
T8531 2111-2113 DT denotes an
T8532 2137-2144 NN denotes defense
T8533 2114-2123 JJ denotes efficient
T8534 2124-2136 JJ denotes anti-cadmium
T8535 2144-2145 . denotes .
T8536 2145-2282 sentence denotes Thus, adequate glutathione supply as well as MTF-1 and its target genes are essential for the survival of the cell under cadmium stress.
T8537 2146-2150 RB denotes Thus
T8538 2218-2221 VBP denotes are
T8539 2150-2152 , denotes ,
T8540 2152-2160 JJ denotes adequate
T8541 2173-2179 NN denotes supply
T8542 2161-2172 NN denotes glutathione
T8543 2180-2182 RB denotes as
T8544 2188-2190 IN denotes as
T8545 2183-2187 RB denotes well
T8546 2191-2194 NN denotes MTF
T8547 2194-2195 HYPH denotes -
T8548 2195-2196 CD denotes 1
T8549 2197-2200 CC denotes and
T8550 2201-2204 PRP$ denotes its
T8551 2212-2217 NNS denotes genes
T8552 2205-2211 NN denotes target
T8553 2222-2231 JJ denotes essential
T8554 2232-2235 IN denotes for
T8555 2236-2239 DT denotes the
T8556 2240-2248 NN denotes survival
T8557 2249-2251 IN denotes of
T8558 2252-2255 DT denotes the
T8559 2256-2260 NN denotes cell
T8560 2261-2266 IN denotes under
T8561 2267-2274 NN denotes cadmium
T8562 2275-2281 NN denotes stress
T8563 2281-2282 . denotes .
T8564 2282-2735 sentence denotes Besides genes related to the glutathione pathway, several other stress-related genes were upregulated upon cadmium exposure, including genes for thioredoxin reductase 1 (Txnrd1), one of the reducing enzymes of the antioxidant thioredoxin (46); KDEL endoplasmic reticulum protein retention receptor 2 (Kdelr2) participating in ER stress response (47); and the anti-apoptotic Bcl2-associated athanogene 3 (Bag3) involved in stress-induced apoptosis (48).
T8565 2283-2290 IN denotes Besides
T8566 2373-2384 VBN denotes upregulated
T8567 2291-2296 NNS denotes genes
T8568 2297-2304 VBN denotes related
T8569 2305-2307 IN denotes to
T8570 2308-2311 DT denotes the
T8571 2324-2331 NN denotes pathway
T8572 2312-2323 NN denotes glutathione
T8573 2331-2333 , denotes ,
T8574 2333-2340 JJ denotes several
T8575 2362-2367 NNS denotes genes
T8576 2341-2346 JJ denotes other
T8577 2347-2353 NN denotes stress
T8578 2354-2361 VBN denotes related
T8579 2353-2354 HYPH denotes -
T8580 2368-2372 VBD denotes were
T8581 2385-2389 IN denotes upon
T8582 2390-2397 NN denotes cadmium
T8583 2398-2406 NN denotes exposure
T8584 2406-2408 , denotes ,
T8585 2408-2417 VBG denotes including
T8586 2418-2423 NNS denotes genes
T8587 2424-2427 IN denotes for
T8588 2428-2439 NN denotes thioredoxin
T8589 2440-2449 NN denotes reductase
T8590 2450-2451 CD denotes 1
T8591 2452-2453 -LRB- denotes (
T8592 2453-2459 NN denotes Txnrd1
T8593 2459-2460 -RRB- denotes )
T8594 2460-2462 , denotes ,
T8595 2462-2465 CD denotes one
T8596 2466-2468 IN denotes of
T8597 2469-2472 DT denotes the
T8598 2482-2489 NNS denotes enzymes
T8599 2473-2481 VBG denotes reducing
T8600 2490-2492 IN denotes of
T8601 2493-2496 DT denotes the
T8602 2509-2520 NN denotes thioredoxin
T8603 2497-2508 NN denotes antioxidant
T8604 2521-2522 -LRB- denotes (
T8605 2522-2524 CD denotes 46
T8606 2524-2525 -RRB- denotes )
T8607 2525-2526 : denotes ;
T8608 2527-2531 NN denotes KDEL
T8609 2572-2580 NN denotes receptor
T8610 2532-2543 JJ denotes endoplasmic
T8611 2544-2553 NN denotes reticulum
T8612 2554-2561 NN denotes protein
T8613 2562-2571 NN denotes retention
T8614 2581-2582 CD denotes 2
T8615 2583-2584 -LRB- denotes (
T8616 2584-2590 NN denotes Kdelr2
T8617 2590-2591 -RRB- denotes )
T8618 2592-2605 VBG denotes participating
T8619 2606-2608 IN denotes in
T8620 2609-2611 NN denotes ER
T8621 2619-2627 NN denotes response
T8622 2612-2618 NN denotes stress
T8623 2628-2629 -LRB- denotes (
T8624 2629-2631 CD denotes 47
T8625 2631-2632 -RRB- denotes )
T8626 2632-2633 : denotes ;
T8627 2634-2637 CC denotes and
T8628 2638-2641 DT denotes the
T8629 2673-2683 NN denotes athanogene
T8630 2642-2656 JJ denotes anti-apoptotic
T8631 2657-2661 NN denotes Bcl2
T8632 2661-2662 HYPH denotes -
T8633 2662-2672 VBN denotes associated
T8634 2684-2685 CD denotes 3
T8635 2686-2687 -LRB- denotes (
T8636 2687-2691 NN denotes Bag3
T8637 2691-2692 -RRB- denotes )
T8638 2693-2701 VBN denotes involved
T8639 2702-2704 IN denotes in
T8640 2705-2711 NN denotes stress
T8641 2712-2719 VBN denotes induced
T8642 2711-2712 HYPH denotes -
T8643 2720-2729 NN denotes apoptosis
T8644 2730-2731 -LRB- denotes (
T8645 2731-2733 CD denotes 48
T8646 2733-2734 -RRB- denotes )
T8647 2734-2735 . denotes .
R5034 T8110 T8111 npadvmod Cadmium,responsive
R5035 T8111 T8113 amod responsive,genes
R5036 T8112 T8111 punct -,responsive
R5037 T8114 T8113 punct ", ",genes
R5038 T8115 T8116 npadvmod MTF,independent
R5039 T8116 T8113 amod independent,genes
R5040 T8117 T8115 punct -,MTF
R5041 T8118 T8115 nummod 1,MTF
R5042 T8119 T8116 punct -,independent
R5043 T8121 T8122 advmod Finally,identified
R5044 T8123 T8122 punct ", ",identified
R5045 T8124 T8122 nsubj we,identified
R5046 T8125 T8122 advmod also,identified
R5047 T8126 T8127 det a,number
R5048 T8127 T8122 dobj number,identified
R5049 T8128 T8127 prep of,number
R5050 T8129 T8130 npadvmod cadmium,responsive
R5051 T8130 T8132 amod responsive,genes
R5052 T8131 T8130 punct -,responsive
R5053 T8132 T8128 pobj genes,of
R5054 T8133 T8134 dep that,were
R5055 T8134 T8127 relcl were,number
R5056 T8135 T8134 acomp independent,were
R5057 T8136 T8135 prep of,independent
R5058 T8137 T8138 nmod MTF,presence
R5059 T8138 T8136 pobj presence,of
R5060 T8139 T8137 punct -,MTF
R5061 T8140 T8137 nummod 1,MTF
R5062 T8141 T8122 punct ", ",identified
R5063 T8142 T8122 prep by,identified
R5064 T8143 T8142 pcomp comparing,by
R5065 T8144 T8145 det the,data
R5066 T8145 T8143 dobj data,comparing
R5067 T8146 T8145 compound probe,data
R5068 T8147 T8145 compound array,data
R5069 T8148 T8145 prep of,data
R5070 T8149 T8150 det all,mice
R5071 T8150 T8148 pobj mice,of
R5072 T8151 T8152 npadvmod cadmium,treated
R5073 T8152 T8150 amod treated,mice
R5074 T8153 T8152 punct -,treated
R5075 T8154 T8143 prep with,comparing
R5076 T8155 T8156 det the,data
R5077 T8156 T8154 pobj data,with
R5078 T8157 T8156 prep of,data
R5079 T8158 T8159 det all,mice
R5080 T8159 T8157 pobj mice,of
R5081 T8160 T8161 amod mock,treated
R5082 T8161 T8159 amod treated,mice
R5083 T8162 T8161 punct -,treated
R5084 T8163 T8143 punct ", ",comparing
R5085 T8164 T8143 advmod irrespective,comparing
R5086 T8165 T8164 prep of,irrespective
R5087 T8166 T8167 det the,genotype
R5088 T8167 T8165 pobj genotype,of
R5089 T8168 T8169 punct (,Table
R5090 T8169 T8143 parataxis Table,comparing
R5091 T8170 T8169 nummod 2,Table
R5092 T8171 T8169 punct ),Table
R5093 T8172 T8122 punct .,identified
R5094 T8174 T8175 det An,upregulation
R5095 T8175 T8181 nsubjpass upregulation,observed
R5096 T8176 T8177 advmod at,least
R5097 T8177 T8178 advmod least,2-fold
R5098 T8178 T8175 amod 2-fold,upregulation
R5099 T8179 T8175 punct ", ",upregulation
R5100 T8180 T8175 amod reliable,upregulation
R5101 T8182 T8181 auxpass was,observed
R5102 T8183 T8181 prep after,observed
R5103 T8184 T8185 compound cadmium,exposure
R5104 T8185 T8183 pobj exposure,after
R5105 T8186 T8181 prep for,observed
R5106 T8187 T8188 nummod 31,sets
R5107 T8188 T8186 pobj sets,for
R5108 T8189 T8188 compound probe,sets
R5109 T8190 T8188 acl corresponding,sets
R5110 T8191 T8190 prep to,corresponding
R5111 T8192 T8193 nummod 21,genes
R5112 T8193 T8191 pobj genes,to
R5113 T8194 T8193 amod different,genes
R5114 T8195 T8193 amod characterized,genes
R5115 T8196 T8197 punct (,a
R5116 T8197 T8181 parataxis a,observed
R5117 T8198 T8197 nmod Table,a
R5118 T8199 T8197 nummod 2,a
R5119 T8200 T8197 punct ", ",a
R5120 T8201 T8197 punct ),a
R5121 T8202 T8181 punct .,observed
R5122 T8204 T8205 prep For,detected
R5123 T8206 T8207 nummod 2,sets
R5124 T8207 T8204 pobj sets,For
R5125 T8208 T8207 compound probe,sets
R5126 T8209 T8207 acl corresponding,sets
R5127 T8210 T8209 prep to,corresponding
R5128 T8211 T8212 nummod 2,genes
R5129 T8212 T8210 pobj genes,to
R5130 T8213 T8212 amod characterized,genes
R5131 T8214 T8205 punct ", ",detected
R5132 T8215 T8216 det an,downregulation
R5133 T8216 T8205 nsubjpass downregulation,detected
R5134 T8217 T8218 advmod at,least
R5135 T8218 T8219 advmod least,2-fold
R5136 T8219 T8216 amod 2-fold,downregulation
R5137 T8220 T8205 auxpass was,detected
R5138 T8221 T8222 punct (,b
R5139 T8222 T8205 parataxis b,detected
R5140 T8223 T8222 nmod Table,b
R5141 T8224 T8222 nummod 2,b
R5142 T8225 T8222 punct ", ",b
R5143 T8226 T8222 punct ),b
R5144 T8227 T8205 punct .,detected
R5145 T8229 T8230 amod Several,genes
R5146 T8230 T8231 nsubjpass genes,found
R5147 T8232 T8230 acl involved,genes
R5148 T8233 T8232 prep in,involved
R5149 T8234 T8235 det the,metabolism
R5150 T8235 T8233 pobj metabolism,in
R5151 T8236 T8235 prep of,metabolism
R5152 T8237 T8238 det the,glutathione
R5153 T8238 T8236 pobj glutathione,of
R5154 T8239 T8238 compound antioxidant,glutathione
R5155 T8240 T8231 auxpass were,found
R5156 T8241 T8242 aux to,upregulated
R5157 T8242 T8231 xcomp upregulated,found
R5158 T8243 T8242 auxpass be,upregulated
R5159 T8244 T8242 agent by,upregulated
R5160 T8245 T8246 compound cadmium,exposure
R5161 T8246 T8244 pobj exposure,by
R5162 T8247 T8242 punct ", ",upregulated
R5163 T8248 T8249 advmod namely,genes
R5164 T8249 T8242 dobj genes,upregulated
R5165 T8250 T8249 det the,genes
R5166 T8251 T8249 acl encoding,genes
R5167 T8252 T8253 det the,subunit
R5168 T8253 T8251 dobj subunit,encoding
R5169 T8254 T8253 amod catalytic,subunit
R5170 T8255 T8253 prep of,subunit
R5171 T8256 T8257 compound glutamate,ligase
R5172 T8257 T8255 pobj ligase,of
R5173 T8258 T8257 punct -,ligase
R5174 T8259 T8257 compound cysteine,ligase
R5175 T8260 T8253 punct (,subunit
R5176 T8261 T8253 appos Gclc,subunit
R5177 T8262 T8253 punct ),subunit
R5178 T8263 T8264 dep that,is
R5179 T8264 T8253 relcl is,subunit
R5180 T8265 T8266 det the,enzyme
R5181 T8266 T8264 attr enzyme,is
R5182 T8267 T8268 npadvmod rate,limiting
R5183 T8268 T8266 amod limiting,enzyme
R5184 T8269 T8266 prep in,enzyme
R5185 T8270 T8271 advmod de,novo
R5186 T8271 T8272 amod novo,synthesis
R5187 T8272 T8269 pobj synthesis,in
R5188 T8273 T8272 prep of,synthesis
R5189 T8274 T8273 pobj glutathione,of
R5190 T8275 T8276 punct (,45
R5191 T8276 T8264 parataxis 45,is
R5192 T8277 T8276 punct ),45
R5193 T8278 T8249 punct ;,genes
R5194 T8279 T8280 compound glutathione,reductase
R5195 T8280 T8249 conj reductase,genes
R5196 T8281 T8280 nummod 1,reductase
R5197 T8282 T8280 punct (,reductase
R5198 T8283 T8280 appos Gsr,reductase
R5199 T8284 T8280 punct ),reductase
R5200 T8285 T8280 punct ", ",reductase
R5201 T8286 T8287 det the,enzyme
R5202 T8287 T8280 appos enzyme,reductase
R5203 T8288 T8287 amod reducing,enzyme
R5204 T8289 T8287 prep for,enzyme
R5205 T8290 T8291 amod oxidized,glutathione
R5206 T8291 T8289 pobj glutathione,for
R5207 T8292 T8293 punct (,45
R5208 T8293 T8291 parataxis 45,glutathione
R5209 T8294 T8293 punct ),45
R5210 T8295 T8280 punct ;,reductase
R5211 T8296 T8280 cc and,reductase
R5212 T8297 T8298 compound glutathione,transferase
R5213 T8298 T8280 conj transferase,reductase
R5214 T8299 T8298 punct -,transferase
R5215 T8300 T8298 compound S,transferase
R5216 T8301 T8298 punct -,transferase
R5217 T8302 T8298 punct ", ",transferase
R5218 T8303 T8304 nmod mu,Gstm4
R5219 T8304 T8298 appos Gstm4,transferase
R5220 T8305 T8304 nummod 4,Gstm4
R5221 T8306 T8304 punct (,Gstm4
R5222 T8307 T8304 punct ),Gstm4
R5223 T8308 T8298 punct ", ",transferase
R5224 T8309 T8310 dep which,is
R5225 T8310 T8298 relcl is,transferase
R5226 T8311 T8312 det a,member
R5227 T8312 T8310 attr member,is
R5228 T8313 T8312 prep of,member
R5229 T8314 T8315 det the,family
R5230 T8315 T8313 pobj family,of
R5231 T8316 T8317 compound glutathione,transferase
R5232 T8317 T8315 compound transferase,family
R5233 T8318 T8317 punct -,transferase
R5234 T8319 T8317 compound S,transferase
R5235 T8320 T8317 punct -,transferase
R5236 T8321 T8315 compound supergene,family
R5237 T8322 T8315 prep of,family
R5238 T8323 T8324 compound detoxification,enzymes
R5239 T8324 T8322 pobj enzymes,of
R5240 T8325 T8326 punct (,45
R5241 T8326 T8312 parataxis 45,member
R5242 T8327 T8326 punct ),45
R5243 T8328 T8231 punct .,found
R5244 T8330 T8331 prep In,confirmed
R5245 T8332 T8330 pobj all,In
R5246 T8333 T8332 prep of,all
R5247 T8334 T8335 det these,cases
R5248 T8335 T8333 pobj cases,of
R5249 T8336 T8331 punct ", ",confirmed
R5250 T8337 T8331 nsubjpass induction,confirmed
R5251 T8338 T8331 auxpass was,confirmed
R5252 T8339 T8331 agent by,confirmed
R5253 T8340 T8341 amod semiquantitative,PCRs
R5254 T8341 T8339 pobj PCRs,by
R5255 T8342 T8341 compound RT,PCRs
R5256 T8343 T8341 punct –,PCRs
R5257 T8344 T8345 punct (,shown
R5258 T8345 T8331 parataxis shown,confirmed
R5259 T8346 T8345 nsubj data,shown
R5260 T8347 T8345 neg not,shown
R5261 T8348 T8345 punct ),shown
R5262 T8349 T8331 punct .,confirmed
R5263 T8351 T8352 nsubjpass Gclc,discussed
R5264 T8353 T8351 punct ", ",Gclc
R5265 T8354 T8355 advmod also,referred
R5266 T8355 T8351 acl referred,Gclc
R5267 T8356 T8355 prep to,referred
R5268 T8357 T8355 prep as,referred
R5269 T8358 T8359 amod heavy,chain
R5270 T8359 T8360 compound chain,subunit
R5271 T8360 T8357 pobj subunit,as
R5272 T8361 T8360 prep of,subunit
R5273 T8362 T8363 compound gamma,glutamylcysteine
R5274 T8363 T8365 compound glutamylcysteine,synthetase
R5275 T8364 T8363 punct -,glutamylcysteine
R5276 T8365 T8361 pobj synthetase,of
R5277 T8366 T8360 punct (,subunit
R5278 T8367 T8368 compound Ggcs,hc
R5279 T8368 T8360 appos hc,subunit
R5280 T8369 T8368 punct -,hc
R5281 T8370 T8352 punct ),discussed
R5282 T8371 T8352 punct ", ",discussed
R5283 T8372 T8352 aux had,discussed
R5284 T8373 T8352 auxpass been,discussed
R5285 T8374 T8352 advmod previously,discussed
R5286 T8375 T8352 prep as,discussed
R5287 T8376 T8377 det a,gene
R5288 T8377 T8375 pobj gene,as
R5289 T8378 T8377 compound target,gene
R5290 T8379 T8377 prep of,gene
R5291 T8380 T8379 pobj MTF,of
R5292 T8381 T8380 punct -,MTF
R5293 T8382 T8380 nummod 1,MTF
R5294 T8383 T8384 punct (,6
R5295 T8384 T8352 parataxis 6,discussed
R5296 T8385 T8384 punct ),6
R5297 T8386 T8352 punct .,discussed
R5298 T8388 T8389 poss Our,data
R5299 T8389 T8391 nsubj data,indicate
R5300 T8390 T8389 compound expression,data
R5301 T8392 T8393 mark that,induced
R5302 T8393 T8391 ccomp induced,indicate
R5303 T8394 T8393 nsubjpass Gclc,induced
R5304 T8395 T8393 auxpass is,induced
R5305 T8396 T8393 agent by,induced
R5306 T8397 T8396 pobj cadmium,by
R5307 T8398 T8393 cc but,induced
R5308 T8399 T8393 punct ", ",induced
R5309 T8400 T8401 advmod at,least
R5310 T8401 T8402 advmod least,in
R5311 T8402 T8403 prep in,dependent
R5312 T8403 T8393 amod dependent,induced
R5313 T8404 T8405 det the,liver
R5314 T8405 T8402 pobj liver,in
R5315 T8406 T8405 amod adult,liver
R5316 T8407 T8405 compound mouse,liver
R5317 T8408 T8403 punct ", ",dependent
R5318 T8409 T8403 neg not,dependent
R5319 T8410 T8403 prep on,dependent
R5320 T8411 T8410 pobj MTF,on
R5321 T8412 T8411 punct -,MTF
R5322 T8413 T8411 nummod 1,MTF
R5323 T8414 T8391 punct .,indicate
R5324 T8416 T8417 aux To,analyze
R5325 T8417 T8418 advcl analyze,treated
R5326 T8419 T8420 det the,role
R5327 T8420 T8417 dobj role,analyze
R5328 T8421 T8420 prep of,role
R5329 T8422 T8423 det the,system
R5330 T8423 T8421 pobj system,of
R5331 T8424 T8423 compound glutathione,system
R5332 T8425 T8420 prep in,role
R5333 T8426 T8427 det the,response
R5334 T8427 T8425 pobj response,in
R5335 T8428 T8427 amod cellular,response
R5336 T8429 T8427 compound cadmium,response
R5337 T8430 T8418 punct ", ",treated
R5338 T8431 T8432 nmod mouse,fibroblasts
R5339 T8432 T8418 nsubjpass fibroblasts,treated
R5340 T8433 T8432 amod embryonic,fibroblasts
R5341 T8434 T8432 prep with,fibroblasts
R5342 T8435 T8434 cc and,with
R5343 T8436 T8434 conj without,with
R5344 T8437 T8438 amod functional,Mtf1
R5345 T8438 T8436 pobj Mtf1,without
R5346 T8439 T8418 auxpass were,treated
R5347 T8440 T8418 prep with,treated
R5348 T8441 T8440 pobj cadmium,with
R5349 T8442 T8418 prep in,treated
R5350 T8443 T8442 pobj combination,in
R5351 T8444 T8443 prep with,combination
R5352 T8445 T8444 pobj BSO,with
R5353 T8446 T8445 punct ", ",BSO
R5354 T8447 T8448 det a,inhibitor
R5355 T8448 T8445 appos inhibitor,BSO
R5356 T8449 T8448 amod specific,inhibitor
R5357 T8450 T8448 prep of,inhibitor
R5358 T8451 T8452 compound glutamate,cysteine
R5359 T8452 T8454 compound cysteine,ligase
R5360 T8453 T8452 punct -,cysteine
R5361 T8454 T8450 pobj ligase,of
R5362 T8455 T8456 punct (,31
R5363 T8456 T8454 parataxis 31,ligase
R5364 T8457 T8456 punct ),31
R5365 T8458 T8418 punct ", ",treated
R5366 T8459 T8418 cc and,treated
R5367 T8460 T8461 compound cell,viability
R5368 T8461 T8462 nsubjpass viability,assessed
R5369 T8462 T8418 conj assessed,treated
R5370 T8463 T8462 auxpass was,assessed
R5371 T8464 T8462 agent by,assessed
R5372 T8465 T8466 det a,assay
R5373 T8466 T8464 pobj assay,by
R5374 T8467 T8466 amod colorimetric,assay
R5375 T8468 T8466 prep based,assay
R5376 T8469 T8468 prep on,based
R5377 T8470 T8471 det the,salt
R5378 T8471 T8469 pobj salt,on
R5379 T8472 T8471 compound tetrazolium,salt
R5380 T8473 T8471 appos MTT,salt
R5381 T8474 T8475 punct (,Figure
R5382 T8475 T8462 parataxis Figure,assessed
R5383 T8476 T8475 nummod 6,Figure
R5384 T8477 T8475 punct ),Figure
R5385 T8478 T8462 punct .,assessed
R5386 T8480 T8481 amod Increasing,concentrations
R5387 T8481 T8482 nsubj concentrations,were
R5388 T8483 T8481 prep of,concentrations
R5389 T8484 T8483 pobj BSO,of
R5390 T8485 T8484 cc or,BSO
R5391 T8486 T8484 conj cadmium,BSO
R5392 T8487 T8484 advmod alone,BSO
R5393 T8488 T8482 prep to,were
R5394 T8489 T8490 det some,extent
R5395 T8490 T8488 pobj extent,to
R5396 T8491 T8482 acomp cytotoxic,were
R5397 T8492 T8491 prep for,cytotoxic
R5398 T8493 T8494 det the,lines
R5399 T8494 T8492 pobj lines,for
R5400 T8495 T8494 amod examined,lines
R5401 T8496 T8494 compound cell,lines
R5402 T8497 T8482 punct .,were
R5403 T8499 T8500 nsubj Treatment,resulted
R5404 T8501 T8499 prep with,Treatment
R5405 T8502 T8503 preconj both,BSO
R5406 T8503 T8501 pobj BSO,with
R5407 T8504 T8503 cc and,BSO
R5408 T8505 T8503 conj cadmium,BSO
R5409 T8506 T8500 prep in,resulted
R5410 T8507 T8508 det an,lethality
R5411 T8508 T8506 pobj lethality,in
R5412 T8509 T8508 amod enhanced,lethality
R5413 T8510 T8511 advmod particularly,for
R5414 T8511 T8500 prep for,resulted
R5415 T8512 T8513 det the,cells
R5416 T8513 T8511 pobj cells,for
R5417 T8514 T8513 prep without,cells
R5418 T8515 T8516 amod functional,Mtf1
R5419 T8516 T8514 pobj Mtf1,without
R5420 T8517 T8500 punct ", ",resulted
R5421 T8518 T8500 advcl indicating,resulted
R5422 T8519 T8520 mark that,impair
R5423 T8520 T8518 ccomp impair,indicating
R5424 T8521 T8522 det a,depletion
R5425 T8522 T8520 nsubj depletion,impair
R5426 T8523 T8522 prep of,depletion
R5427 T8524 T8523 pobj glutathione,of
R5428 T8525 T8522 advmod together,depletion
R5429 T8526 T8525 prep with,together
R5430 T8527 T8528 det a,lack
R5431 T8528 T8526 pobj lack,with
R5432 T8529 T8528 prep of,lack
R5433 T8530 T8529 pobj Mtf1,of
R5434 T8531 T8532 det an,defense
R5435 T8532 T8520 dobj defense,impair
R5436 T8533 T8532 amod efficient,defense
R5437 T8534 T8532 amod anti-cadmium,defense
R5438 T8535 T8500 punct .,resulted
R5439 T8537 T8538 advmod Thus,are
R5440 T8539 T8538 punct ", ",are
R5441 T8540 T8541 amod adequate,supply
R5442 T8541 T8538 nsubj supply,are
R5443 T8542 T8541 compound glutathione,supply
R5444 T8543 T8544 advmod as,as
R5445 T8544 T8541 cc as,supply
R5446 T8545 T8544 advmod well,as
R5447 T8546 T8541 conj MTF,supply
R5448 T8547 T8546 punct -,MTF
R5449 T8548 T8546 nummod 1,MTF
R5450 T8549 T8541 cc and,supply
R5451 T8550 T8551 poss its,genes
R5452 T8551 T8541 conj genes,supply
R5453 T8552 T8551 compound target,genes
R5454 T8553 T8538 acomp essential,are
R5455 T8554 T8553 prep for,essential
R5456 T8555 T8556 det the,survival
R5457 T8556 T8554 pobj survival,for
R5458 T8557 T8556 prep of,survival
R5459 T8558 T8559 det the,cell
R5460 T8559 T8557 pobj cell,of
R5461 T8560 T8556 prep under,survival
R5462 T8561 T8562 compound cadmium,stress
R5463 T8562 T8560 pobj stress,under
R5464 T8563 T8538 punct .,are
R5465 T8565 T8566 prep Besides,upregulated
R5466 T8567 T8565 pobj genes,Besides
R5467 T8568 T8567 acl related,genes
R5468 T8569 T8568 prep to,related
R5469 T8570 T8571 det the,pathway
R5470 T8571 T8569 pobj pathway,to
R5471 T8572 T8571 compound glutathione,pathway
R5472 T8573 T8566 punct ", ",upregulated
R5473 T8574 T8575 amod several,genes
R5474 T8575 T8566 nsubjpass genes,upregulated
R5475 T8576 T8575 amod other,genes
R5476 T8577 T8578 npadvmod stress,related
R5477 T8578 T8575 amod related,genes
R5478 T8579 T8578 punct -,related
R5479 T8580 T8566 auxpass were,upregulated
R5480 T8581 T8566 prep upon,upregulated
R5481 T8582 T8583 compound cadmium,exposure
R5482 T8583 T8581 pobj exposure,upon
R5483 T8584 T8566 punct ", ",upregulated
R5484 T8585 T8566 prep including,upregulated
R5485 T8586 T8585 pobj genes,including
R5486 T8587 T8586 prep for,genes
R5487 T8588 T8589 compound thioredoxin,reductase
R5488 T8589 T8587 pobj reductase,for
R5489 T8590 T8589 nummod 1,reductase
R5490 T8591 T8589 punct (,reductase
R5491 T8592 T8589 appos Txnrd1,reductase
R5492 T8593 T8589 punct ),reductase
R5493 T8594 T8589 punct ", ",reductase
R5494 T8595 T8589 appos one,reductase
R5495 T8596 T8595 prep of,one
R5496 T8597 T8598 det the,enzymes
R5497 T8598 T8596 pobj enzymes,of
R5498 T8599 T8598 amod reducing,enzymes
R5499 T8600 T8595 prep of,one
R5500 T8601 T8602 det the,thioredoxin
R5501 T8602 T8600 pobj thioredoxin,of
R5502 T8603 T8602 compound antioxidant,thioredoxin
R5503 T8604 T8605 punct (,46
R5504 T8605 T8602 parataxis 46,thioredoxin
R5505 T8606 T8605 punct ),46
R5506 T8607 T8589 punct ;,reductase
R5507 T8608 T8609 nmod KDEL,receptor
R5508 T8609 T8589 conj receptor,reductase
R5509 T8610 T8609 amod endoplasmic,receptor
R5510 T8611 T8609 compound reticulum,receptor
R5511 T8612 T8609 compound protein,receptor
R5512 T8613 T8609 compound retention,receptor
R5513 T8614 T8609 nummod 2,receptor
R5514 T8615 T8609 punct (,receptor
R5515 T8616 T8609 appos Kdelr2,receptor
R5516 T8617 T8609 punct ),receptor
R5517 T8618 T8609 acl participating,receptor
R5518 T8619 T8618 prep in,participating
R5519 T8620 T8621 compound ER,response
R5520 T8621 T8619 pobj response,in
R5521 T8622 T8621 compound stress,response
R5522 T8623 T8624 punct (,47
R5523 T8624 T8621 parataxis 47,response
R5524 T8625 T8624 punct ),47
R5525 T8626 T8609 punct ;,receptor
R5526 T8627 T8609 cc and,receptor
R5527 T8628 T8629 det the,athanogene
R5528 T8629 T8609 conj athanogene,receptor
R5529 T8630 T8629 amod anti-apoptotic,athanogene
R5530 T8631 T8629 nmod Bcl2,athanogene
R5531 T8632 T8629 punct -,athanogene
R5532 T8633 T8629 amod associated,athanogene
R5533 T8634 T8629 nummod 3,athanogene
R5534 T8635 T8629 punct (,athanogene
R5535 T8636 T8629 appos Bag3,athanogene
R5536 T8637 T8629 punct ),athanogene
R5537 T8638 T8629 acl involved,athanogene
R5538 T8639 T8638 prep in,involved
R5539 T8640 T8641 npadvmod stress,induced
R5540 T8641 T8643 amod induced,apoptosis
R5541 T8642 T8641 punct -,induced
R5542 T8643 T8639 pobj apoptosis,in
R5543 T8644 T8645 punct (,48
R5544 T8645 T8643 parataxis 48,apoptosis
R5545 T8646 T8645 punct ),48
R5546 T8647 T8566 punct .,upregulated

2_test

Id Subject Object Predicate Lexical cue
16221973-14988435-77403437 846-848 14988435 denotes 45
16221973-14988435-77403438 928-930 14988435 denotes 45
16221973-14988435-77403439 1073-1075 14988435 denotes 45
16221973-11746217-77403440 1322-1323 11746217 denotes 6
16221973-38242-77403441 1694-1696 38242 denotes 31
16221973-14980055-77403442 2522-2524 14980055 denotes 46
16221973-12821650-77403443 2629-2631 12821650 denotes 47
16221973-14628070-77403444 2731-2733 14628070 denotes 48

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T7897 20-25 PR:000010717 denotes MTF-1
T7898 38-43 SO:0000704 denotes genes
T7899 103-108 SO:0000704 denotes genes
T7900 134-139 PR:000010717 denotes MTF-1
T7901 207-211 NCBITaxon:10088 denotes mice
T7902 246-250 NCBITaxon:10088 denotes mice
T7903 432-437 SO:0000704 denotes genes
T7904 502-507 SO:0000704 denotes genes
T7905 578-583 SO:0000704 denotes genes
T7906 600-613 _FRAGMENT denotes metabolism of
T7907 630-641 GO:0006749 denotes glutathione
T7908 630-641 CHEBI:16856 denotes glutathione
T7909 703-708 SO:0000704 denotes genes
T7910 722-768 PR:000007897 denotes catalytic subunit of glutamate-cysteine ligase
T7911 770-774 PR:000007897 denotes Gclc
T7912 820-844 GO:0006750 denotes synthesis of glutathione
T7913 833-844 CHEBI:16856 denotes glutathione
T7914 851-862 CHEBI:16856 denotes glutathione
T7915 851-874 PR:000008292 denotes glutathione reductase 1
T7916 886-894 MOP:0000569 denotes reducing
T7917 906-914 MOP:0000568 denotes oxidized
T7918 906-926 CHEBI:17858 denotes oxidized glutathione
T7919 937-948 CHEBI:16856 denotes glutathione
T7920 937-968 PR:000030257 denotes glutathione-S-transferase, mu 4
T7921 970-975 PR:000030257 denotes Gstm4
T7922 1003-1014 CHEBI:16856 denotes glutathione
T7923 1049-1063 GO:0098754 denotes detoxification
T7924 1171-1175 PR:000007897 denotes Gclc
T7925 1197-1253 PR:000007897 denotes heavy chain subunit of gamma-glutamylcysteine synthetase
T7926 1220-1242 CHEBI:24195 denotes gamma-glutamylcysteine
T7927 1255-1262 PR:000007897 denotes Ggcs-hc
T7928 1307-1311 SO:0000704 denotes gene
T7929 1315-1320 PR:000010717 denotes MTF-1
T7930 1330-1340 GO:0010467 denotes expression
T7931 1360-1364 PR:000007897 denotes Gclc
T7932 1408-1413 UBERON:0007023 denotes adult
T7933 1414-1419 NCBITaxon:10088 denotes mouse
T7934 1420-1425 UBERON:0002107 denotes liver
T7935 1444-1449 PR:000010717 denotes MTF-1
T7936 1478-1489 CHEBI:16856 denotes glutathione
T7937 1504-1512 _FRAGMENT denotes cellular
T7938 1521-1529 GO:0051716 denotes response
T7939 1531-1536 NCBITaxon:10088 denotes mouse
T7940 1537-1546 UBERON:0000922 denotes embryonic
T7941 1547-1558 CL:0000057 denotes fibroblasts
T7942 1587-1591 PR:000010717 denotes Mtf1
T7943 1638-1641 CHEBI:28714 denotes BSO
T7944 1654-1692 CHEBI:75599 denotes inhibitor of glutamate-cysteine ligase
T7945 1768-1779 CHEBI:78021 denotes tetrazolium
T7946 1780-1784 CHEBI:24866 denotes salt
T7947 1785-1788 CHEBI:53233 denotes MTT
T7948 1830-1833 CHEBI:28714 denotes BSO
T7949 1930-1933 CHEBI:28714 denotes BSO
T7950 2026-2030 PR:000010717 denotes Mtf1
T7951 2063-2074 CHEBI:16856 denotes glutathione
T7952 2099-2103 PR:000010717 denotes Mtf1
T7953 2137-2144 GO:0006952 denotes defense
T7954 2161-2172 CHEBI:16856 denotes glutathione
T7955 2191-2196 PR:000010717 denotes MTF-1
T7956 2212-2217 SO:0000704 denotes genes
T7957 2291-2296 SO:0000704 denotes genes
T7958 2312-2323 CHEBI:16856 denotes glutathione
T7959 2362-2367 SO:0000704 denotes genes
T7960 2418-2423 SO:0000704 denotes genes
T7961 2428-2451 PR:000016871 denotes thioredoxin reductase 1
T7962 2453-2459 PR:000016871 denotes Txnrd1
T7963 2473-2481 MOP:0000569 denotes reducing
T7964 2527-2582 PR:000009274 denotes KDEL endoplasmic reticulum protein retention receptor 2
T7965 2532-2553 GO:0005783 denotes endoplasmic reticulum
T7966 2532-2571 GO:0035437 denotes endoplasmic reticulum protein retention
T7967 2584-2590 PR:000009274 denotes Kdelr2
T7968 2609-2611 GO:0005783 denotes ER
T7969 2657-2685 PR:000004621 denotes Bcl2-associated athanogene 3
T7970 2687-2691 PR:000004621 denotes Bag3
T7971 2720-2729 GO:0006915 denotes apoptosis
R5029 T7907 T7906 _lexicallyChainedTo glutathione,metabolism of
R5030 T7938 T7937 _lexicallyChainedTo response,cellular

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T7972 0-7 CHEBI_EXT:cadmium denotes Cadmium
T7973 20-25 PR_EXT:000010717 denotes MTF-1
T7974 38-43 SO_EXT:0000704 denotes genes
T7975 84-91 CHEBI_EXT:cadmium denotes cadmium
T7976 103-108 SO_EXT:0000704 denotes genes
T7977 134-139 PR_EXT:000010717 denotes MTF-1
T7978 167-172 CHEBI_SO_EXT:molecular_probe denotes probe
T7979 191-198 CHEBI_EXT:cadmium denotes cadmium
T7980 207-211 NCBITaxon:10088 denotes mice
T7981 246-250 NCBITaxon:10088 denotes mice
T7982 272-280 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T7983 321-333 GO_EXT:positive_regulation denotes upregulation
T7984 353-360 CHEBI_EXT:cadmium denotes cadmium
T7985 377-382 CHEBI_SO_EXT:molecular_probe denotes probe
T7986 432-437 SO_EXT:0000704 denotes genes
T7987 458-463 CHEBI_SO_EXT:molecular_probe denotes probe
T7988 502-507 SO_EXT:0000704 denotes genes
T7989 528-542 GO_EXT:negative_regulation denotes downregulation
T7990 578-583 SO_EXT:0000704 denotes genes
T7991 600-613 _FRAGMENT denotes metabolism of
T7992 630-641 GO:0006749 denotes glutathione
T7993 618-629 CHEBI_GO_EXT:antioxidant denotes antioxidant
T7994 622-629 CHEBI_MOP_EXT:oxidising_agent_or_oxidation denotes oxidant
T7995 630-641 CHEBI:16856 denotes glutathione
T7996 659-670 GO_EXT:positive_regulation denotes upregulated
T7997 674-681 CHEBI_EXT:cadmium denotes cadmium
T7998 703-708 SO_EXT:0000704 denotes genes
T7999 709-717 SO_EXT:sequence_coding_function denotes encoding
T8000 722-731 GO_MOP_EXT:catalysis denotes catalytic
T8001 722-768 PR_EXT:000007897 denotes catalytic subunit of glutamate-cysteine ligase
T8002 743-752 CHEBI_EXT:glutamate denotes glutamate
T8003 743-768 GO_EXT:0004357 denotes glutamate-cysteine ligase
T8004 753-761 CHEBI_SO_EXT:cysteine denotes cysteine
T8005 770-774 PR_EXT:000007897 denotes Gclc
T8006 770-774 GO_EXT:0004357 denotes Gclc
T8007 802-808 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T8008 820-844 GO:0006750 denotes synthesis of glutathione
T8009 833-844 CHEBI:16856 denotes glutathione
T8010 851-862 CHEBI:16856 denotes glutathione
T8011 851-872 GO_PR_EXT:glutathione_disulfide_reductase denotes glutathione reductase
T8012 851-874 PR_EXT:000008292 denotes glutathione reductase 1
T8013 876-879 GO_PR_EXT:glutathione_disulfide_reductase denotes Gsr
T8014 886-894 MOP:0000569 denotes reducing
T8015 895-901 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T8016 906-914 MOP:0000568 denotes oxidized
T8017 906-926 CHEBI:17858 denotes oxidized glutathione
T8018 937-948 CHEBI:16856 denotes glutathione
T8019 937-962 GO_PR_EXT:glutathione_S_transferase denotes glutathione-S-transferase
T8020 937-968 PR_EXT:000030257 denotes glutathione-S-transferase, mu 4
T8021 949-950 CHEBI_EXT:sulfur denotes S
T8022 970-975 PR_EXT:000030257 denotes Gstm4
T8023 1003-1014 CHEBI:16856 denotes glutathione
T8024 1003-1028 GO_PR_EXT:glutathione_S_transferase denotes glutathione-S-transferase
T8025 1015-1016 CHEBI_EXT:sulfur denotes S
T8026 1049-1063 GO:0098754 denotes detoxification
T8027 1064-1071 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T8028 1145-1147 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T8029 1171-1175 PR_EXT:000007897 denotes Gclc
T8030 1171-1175 GO_EXT:0004357 denotes Gclc
T8031 1197-1253 PR_EXT:000007897 denotes heavy chain subunit of gamma-glutamylcysteine synthetase
T8032 1220-1242 CHEBI:24195 denotes gamma-glutamylcysteine
T8033 1220-1253 GO_EXT:0004357 denotes gamma-glutamylcysteine synthetase
T8034 1255-1259 GO_EXT:0004357 denotes Ggcs
T8035 1255-1262 PR_EXT:000007897 denotes Ggcs-hc
T8036 1307-1311 SO_EXT:0000704 denotes gene
T8037 1315-1320 PR_EXT:000010717 denotes MTF-1
T8038 1330-1340 GO:0010467 denotes expression
T8039 1360-1364 PR_EXT:000007897 denotes Gclc
T8040 1360-1364 GO_EXT:0004357 denotes Gclc
T8041 1379-1386 CHEBI_EXT:cadmium denotes cadmium
T8042 1408-1413 UBERON:0007023 denotes adult
T8043 1414-1419 NCBITaxon:10088 denotes mouse
T8044 1420-1425 UBERON:0002107 denotes liver
T8045 1444-1449 PR_EXT:000010717 denotes MTF-1
T8046 1478-1489 CHEBI:16856 denotes glutathione
T8047 1504-1512 CL_GO_EXT:cell denotes cellular
T8048 1504-1512 _FRAGMENT denotes cellular
T8049 1521-1529 GO:0051716 denotes response
T8050 1513-1520 CHEBI_EXT:cadmium denotes cadmium
T8051 1531-1536 NCBITaxon:10088 denotes mouse
T8052 1537-1546 UBERON:0000922 denotes embryonic
T8053 1547-1558 CL:0000057 denotes fibroblasts
T8054 1587-1591 PR_EXT:000010717 denotes Mtf1
T8055 1610-1617 CHEBI_EXT:cadmium denotes cadmium
T8056 1638-1641 CHEBI:28714 denotes BSO
T8057 1654-1666 _FRAGMENT denotes inhibitor of
T8058 1686-1692 CHEBI_GO_EXT:ligase_inhibitor denotes ligase
T8059 1654-1692 CHEBI_EXT:75599 denotes inhibitor of glutamate-cysteine ligase
T8060 1667-1692 GO_EXT:0004357 denotes glutamate-cysteine ligase
T8061 1677-1685 CHEBI_SO_EXT:cysteine denotes cysteine
T8062 1703-1707 CL_GO_EXT:cell denotes cell
T8063 1768-1779 CHEBI:78021 denotes tetrazolium
T8064 1780-1784 CHEBI:24866 denotes salt
T8065 1785-1788 CHEBI:53233 denotes MTT
T8066 1830-1833 CHEBI:28714 denotes BSO
T8067 1837-1844 CHEBI_EXT:cadmium denotes cadmium
T8068 1898-1902 CL_GO_EXT:cell denotes cell
T8069 1930-1933 CHEBI:28714 denotes BSO
T8070 1938-1945 CHEBI_EXT:cadmium denotes cadmium
T8071 1970-1979 GO_EXT:fatality_or_lethality denotes lethality
T8072 2001-2006 CL_GO_EXT:cell denotes cells
T8073 2026-2030 PR_EXT:000010717 denotes Mtf1
T8074 2063-2074 CHEBI:16856 denotes glutathione
T8075 2099-2103 PR_EXT:000010717 denotes Mtf1
T8076 2129-2136 CHEBI_EXT:cadmium denotes cadmium
T8077 2137-2144 GO:0006952 denotes defense
T8078 2161-2172 CHEBI:16856 denotes glutathione
T8079 2191-2196 PR_EXT:000010717 denotes MTF-1
T8080 2212-2217 SO_EXT:0000704 denotes genes
T8081 2256-2260 CL_GO_EXT:cell denotes cell
T8082 2267-2274 CHEBI_EXT:cadmium denotes cadmium
T8083 2291-2296 SO_EXT:0000704 denotes genes
T8084 2312-2323 CHEBI:16856 denotes glutathione
T8085 2362-2367 SO_EXT:0000704 denotes genes
T8086 2373-2384 GO_EXT:positive_regulation denotes upregulated
T8087 2390-2397 CHEBI_EXT:cadmium denotes cadmium
T8088 2418-2423 SO_EXT:0000704 denotes genes
T8089 2428-2439 CHEBI_PR_EXT:thioredoxin denotes thioredoxin
T8090 2428-2449 GO_EXT:0004791 denotes thioredoxin reductase
T8091 2428-2451 PR_EXT:000016871 denotes thioredoxin reductase 1
T8092 2453-2459 PR_EXT:000016871 denotes Txnrd1
T8093 2473-2481 MOP:0000569 denotes reducing
T8094 2482-2489 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T8095 2497-2508 CHEBI_GO_EXT:antioxidant denotes antioxidant
T8096 2501-2508 CHEBI_MOP_EXT:oxidising_agent_or_oxidation denotes oxidant
T8097 2509-2520 CHEBI_PR_EXT:thioredoxin denotes thioredoxin
T8098 2527-2582 PR_EXT:000009274 denotes KDEL endoplasmic reticulum protein retention receptor 2
T8099 2532-2553 GO:0005783 denotes endoplasmic reticulum
T8100 2532-2571 GO:0035437 denotes endoplasmic reticulum protein retention
T8101 2554-2561 CHEBI_PR_EXT:protein denotes protein
T8102 2572-2580 GO_EXT:0004872 denotes receptor
T8103 2584-2590 PR_EXT:000009274 denotes Kdelr2
T8104 2609-2611 GO:0005783 denotes ER
T8105 2619-2627 GO_EXT:reaction_or_response denotes response
T8106 2647-2656 GO_PATO_EXT:apoptotic_process_or_quality denotes apoptotic
T8107 2657-2685 PR_EXT:000004621 denotes Bcl2-associated athanogene 3
T8108 2687-2691 PR_EXT:000004621 denotes Bag3
T8109 2720-2729 GO:0006915 denotes apoptosis
R5031 T7992 T7991 _lexicallyChainedTo glutathione,metabolism of
R5032 T8049 T8048 _lexicallyChainedTo response,cellular
R5033 T8058 T8057 _lexicallyChainedTo ligase,inhibitor of