PMC:1253828 / 19545-20119
Annnotations
craft-sa-dev
{"project":"craft-sa-dev","denotations":[{"id":"T5834","span":{"begin":0,"end":3},"obj":"IN"},{"id":"T5835","span":{"begin":82,"end":88},"obj":"VBZ"},{"id":"T5836","span":{"begin":4,"end":7},"obj":"DT"},{"id":"T5837","span":{"begin":21,"end":26},"obj":"NNS"},{"id":"T5838","span":{"begin":8,"end":11},"obj":"NN"},{"id":"T5839","span":{"begin":11,"end":12},"obj":"HYPH"},{"id":"T5840","span":{"begin":12,"end":13},"obj":"CD"},{"id":"T5841","span":{"begin":14,"end":20},"obj":"NN"},{"id":"T5842","span":{"begin":27,"end":40},"obj":"VBN"},{"id":"T5843","span":{"begin":41,"end":43},"obj":"RB"},{"id":"T5844","span":{"begin":44,"end":47},"obj":"RB"},{"id":"T5845","span":{"begin":47,"end":49},"obj":","},{"id":"T5846","span":{"begin":49,"end":53},"obj":"JJ"},{"id":"T5847","span":{"begin":54,"end":56},"obj":"IN"},{"id":"T5848","span":{"begin":57,"end":60},"obj":"NN"},{"id":"T5849","span":{"begin":60,"end":62},"obj":","},{"id":"T5850","span":{"begin":62,"end":65},"obj":"NN"},{"id":"T5851","span":{"begin":66,"end":69},"obj":"CC"},{"id":"T5852","span":{"begin":70,"end":74},"obj":"NN"},{"id":"T5853","span":{"begin":74,"end":76},"obj":","},{"id":"T5854","span":{"begin":76,"end":79},"obj":"NN"},{"id":"T5855","span":{"begin":79,"end":80},"obj":"HYPH"},{"id":"T5856","span":{"begin":80,"end":81},"obj":"CD"},{"id":"T5857","span":{"begin":89,"end":92},"obj":"PRP$"},{"id":"T5858","span":{"begin":120,"end":128},"obj":"NN"},{"id":"T5859","span":{"begin":93,"end":108},"obj":"JJ"},{"id":"T5860","span":{"begin":109,"end":119},"obj":"NN"},{"id":"T5861","span":{"begin":129,"end":132},"obj":"IN"},{"id":"T5862","span":{"begin":133,"end":141},"obj":"JJ"},{"id":"T5863","span":{"begin":146,"end":155},"obj":"NNS"},{"id":"T5864","span":{"begin":142,"end":145},"obj":"NN"},{"id":"T5865","span":{"begin":156,"end":163},"obj":"VBN"},{"id":"T5866","span":{"begin":164,"end":172},"obj":"RB"},{"id":"T5867","span":{"begin":173,"end":175},"obj":"IN"},{"id":"T5868","span":{"begin":176,"end":179},"obj":"DT"},{"id":"T5869","span":{"begin":194,"end":199},"obj":"NN"},{"id":"T5870","span":{"begin":180,"end":193},"obj":"NN"},{"id":"T5871","span":{"begin":200,"end":201},"obj":"-LRB-"},{"id":"T5872","span":{"begin":210,"end":212},"obj":"CD"},{"id":"T5873","span":{"begin":201,"end":202},"obj":"CD"},{"id":"T5874","span":{"begin":202,"end":203},"obj":","},{"id":"T5875","span":{"begin":203,"end":204},"obj":"CD"},{"id":"T5876","span":{"begin":204,"end":205},"obj":","},{"id":"T5877","span":{"begin":205,"end":206},"obj":"CD"},{"id":"T5878","span":{"begin":206,"end":207},"obj":","},{"id":"T5879","span":{"begin":207,"end":209},"obj":"CD"},{"id":"T5880","span":{"begin":209,"end":210},"obj":","},{"id":"T5881","span":{"begin":212,"end":213},"obj":"-RRB-"},{"id":"T5882","span":{"begin":213,"end":214},"obj":"."},{"id":"T5883","span":{"begin":214,"end":419},"obj":"sentence"},{"id":"T5884","span":{"begin":215,"end":219},"obj":"RB"},{"id":"T5885","span":{"begin":231,"end":237},"obj":"NN"},{"id":"T5886","span":{"begin":220,"end":221},"obj":"DT"},{"id":"T5887","span":{"begin":222,"end":230},"obj":"JJ"},{"id":"T5888","span":{"begin":345,"end":352},"obj":"VBD"},{"id":"T5889","span":{"begin":238,"end":241},"obj":"IN"},{"id":"T5890","span":{"begin":242,"end":245},"obj":"NN"},{"id":"T5891","span":{"begin":256,"end":261},"obj":"NNS"},{"id":"T5892","span":{"begin":245,"end":246},"obj":"HYPH"},{"id":"T5893","span":{"begin":246,"end":247},"obj":"CD"},{"id":"T5894","span":{"begin":248,"end":255},"obj":"NN"},{"id":"T5895","span":{"begin":262,"end":264},"obj":"IN"},{"id":"T5896","span":{"begin":265,"end":274},"obj":"NN"},{"id":"T5897","span":{"begin":275,"end":279},"obj":"IN"},{"id":"T5898","span":{"begin":280,"end":281},"obj":"DT"},{"id":"T5899","span":{"begin":282,"end":286},"obj":"NN"},{"id":"T5900","span":{"begin":287,"end":289},"obj":"IN"},{"id":"T5901","span":{"begin":290,"end":296},"obj":"JJ"},{"id":"T5902","span":{"begin":297,"end":305},"obj":"VBN"},{"id":"T5903","span":{"begin":296,"end":297},"obj":"HYPH"},{"id":"T5904","span":{"begin":306,"end":322},"obj":"NNS"},{"id":"T5905","span":{"begin":323,"end":327},"obj":"IN"},{"id":"T5906","span":{"begin":328,"end":334},"obj":"JJ"},{"id":"T5907","span":{"begin":335,"end":344},"obj":"NNS"},{"id":"T5908","span":{"begin":353,"end":355},"obj":"DT"},{"id":"T5909","span":{"begin":368,"end":373},"obj":"NN"},{"id":"T5910","span":{"begin":356,"end":359},"obj":"JJ"},{"id":"T5911","span":{"begin":360,"end":367},"obj":"NN"},{"id":"T5912","span":{"begin":374,"end":377},"obj":"IN"},{"id":"T5913","span":{"begin":378,"end":381},"obj":"NN"},{"id":"T5914","span":{"begin":381,"end":382},"obj":"HYPH"},{"id":"T5915","span":{"begin":382,"end":383},"obj":"CD"},{"id":"T5916","span":{"begin":384,"end":386},"obj":"IN"},{"id":"T5917","span":{"begin":387,"end":395},"obj":"NN"},{"id":"T5918","span":{"begin":396,"end":398},"obj":"IN"},{"id":"T5919","span":{"begin":399,"end":402},"obj":"DT"},{"id":"T5920","span":{"begin":409,"end":413},"obj":"NNS"},{"id":"T5921","span":{"begin":403,"end":408},"obj":"JJ"},{"id":"T5922","span":{"begin":414,"end":415},"obj":"-LRB-"},{"id":"T5923","span":{"begin":415,"end":417},"obj":"CD"},{"id":"T5924","span":{"begin":417,"end":418},"obj":"-RRB-"},{"id":"T5925","span":{"begin":418,"end":419},"obj":"."},{"id":"T5926","span":{"begin":419,"end":574},"obj":"sentence"},{"id":"T5927","span":{"begin":420,"end":424},"obj":"RB"},{"id":"T5928","span":{"begin":442,"end":444},"obj":"VBZ"},{"id":"T5929","span":{"begin":424,"end":426},"obj":","},{"id":"T5930","span":{"begin":426,"end":428},"obj":"DT"},{"id":"T5931","span":{"begin":433,"end":441},"obj":"NN"},{"id":"T5932","span":{"begin":429,"end":432},"obj":"NN"},{"id":"T5933","span":{"begin":445,"end":447},"obj":"IN"},{"id":"T5934","span":{"begin":448,"end":452},"obj":"NN"},{"id":"T5935","span":{"begin":453,"end":456},"obj":"DT"},{"id":"T5936","span":{"begin":462,"end":472},"obj":"NN"},{"id":"T5937","span":{"begin":457,"end":461},"obj":"JJ"},{"id":"T5938","span":{"begin":473,"end":476},"obj":"IN"},{"id":"T5939","span":{"begin":477,"end":478},"obj":"DT"},{"id":"T5940","span":{"begin":499,"end":503},"obj":"NN"},{"id":"T5941","span":{"begin":479,"end":485},"obj":"JJ"},{"id":"T5942","span":{"begin":486,"end":489},"obj":"NN"},{"id":"T5943","span":{"begin":489,"end":490},"obj":"HYPH"},{"id":"T5944","span":{"begin":490,"end":491},"obj":"CD"},{"id":"T5945","span":{"begin":492,"end":498},"obj":"NN"},{"id":"T5946","span":{"begin":503,"end":505},"obj":","},{"id":"T5947","span":{"begin":505,"end":508},"obj":"CC"},{"id":"T5948","span":{"begin":509,"end":513},"obj":"CD"},{"id":"T5949","span":{"begin":541,"end":551},"obj":"NNS"},{"id":"T5950","span":{"begin":514,"end":517},"obj":"NN"},{"id":"T5951","span":{"begin":518,"end":528},"obj":"VBG"},{"id":"T5952","span":{"begin":517,"end":518},"obj":"HYPH"},{"id":"T5953","span":{"begin":529,"end":535},"obj":"NN"},{"id":"T5954","span":{"begin":536,"end":540},"obj":"NN"},{"id":"T5955","span":{"begin":565,"end":573},"obj":"VBN"},{"id":"T5956","span":{"begin":552,"end":556},"obj":"VBD"},{"id":"T5957","span":{"begin":557,"end":564},"obj":"RB"},{"id":"T5958","span":{"begin":573,"end":574},"obj":"."}],"relations":[{"id":"R3796","pred":"prep","subj":"T5834","obj":"T5835"},{"id":"R3797","pred":"det","subj":"T5836","obj":"T5837"},{"id":"R3798","pred":"pobj","subj":"T5837","obj":"T5834"},{"id":"R3799","pred":"nmod","subj":"T5838","obj":"T5837"},{"id":"R3800","pred":"punct","subj":"T5839","obj":"T5838"},{"id":"R3801","pred":"nummod","subj":"T5840","obj":"T5838"},{"id":"R3802","pred":"compound","subj":"T5841","obj":"T5837"},{"id":"R3803","pred":"acl","subj":"T5842","obj":"T5837"},{"id":"R3804","pred":"advmod","subj":"T5843","obj":"T5844"},{"id":"R3805","pred":"advmod","subj":"T5844","obj":"T5842"},{"id":"R3806","pred":"punct","subj":"T5845","obj":"T5837"},{"id":"R3807","pred":"amod","subj":"T5846","obj":"T5847"},{"id":"R3808","pred":"prep","subj":"T5847","obj":"T5837"},{"id":"R3809","pred":"pobj","subj":"T5848","obj":"T5847"},{"id":"R3810","pred":"punct","subj":"T5849","obj":"T5848"},{"id":"R3811","pred":"conj","subj":"T5850","obj":"T5848"},{"id":"R3812","pred":"cc","subj":"T5851","obj":"T5850"},{"id":"R3813","pred":"conj","subj":"T5852","obj":"T5850"},{"id":"R3814","pred":"punct","subj":"T5853","obj":"T5835"},{"id":"R3815","pred":"nsubj","subj":"T5854","obj":"T5835"},{"id":"R3816","pred":"punct","subj":"T5855","obj":"T5854"},{"id":"R3817","pred":"nummod","subj":"T5856","obj":"T5854"},{"id":"R3818","pred":"poss","subj":"T5857","obj":"T5858"},{"id":"R3819","pred":"dobj","subj":"T5858","obj":"T5835"},{"id":"R3820","pred":"amod","subj":"T5859","obj":"T5860"},{"id":"R3821","pred":"compound","subj":"T5860","obj":"T5858"},{"id":"R3822","pred":"prep","subj":"T5861","obj":"T5835"},{"id":"R3823","pred":"amod","subj":"T5862","obj":"T5863"},{"id":"R3824","pred":"pobj","subj":"T5863","obj":"T5861"},{"id":"R3825","pred":"compound","subj":"T5864","obj":"T5863"},{"id":"R3826","pred":"acl","subj":"T5865","obj":"T5863"},{"id":"R3827","pred":"advmod","subj":"T5866","obj":"T5865"},{"id":"R3828","pred":"prep","subj":"T5867","obj":"T5866"},{"id":"R3829","pred":"det","subj":"T5868","obj":"T5869"},{"id":"R3830","pred":"pobj","subj":"T5869","obj":"T5867"},{"id":"R3831","pred":"compound","subj":"T5870","obj":"T5869"},{"id":"R3832","pred":"punct","subj":"T5871","obj":"T5872"},{"id":"R3833","pred":"parataxis","subj":"T5872","obj":"T5835"},{"id":"R3834","pred":"nummod","subj":"T5873","obj":"T5872"},{"id":"R3835","pred":"punct","subj":"T5874","obj":"T5872"},{"id":"R3836","pred":"nummod","subj":"T5875","obj":"T5872"},{"id":"R3837","pred":"punct","subj":"T5876","obj":"T5872"},{"id":"R3838","pred":"nummod","subj":"T5877","obj":"T5872"},{"id":"R3839","pred":"punct","subj":"T5878","obj":"T5872"},{"id":"R3840","pred":"nummod","subj":"T5879","obj":"T5872"},{"id":"R3841","pred":"punct","subj":"T5880","obj":"T5872"},{"id":"R3842","pred":"punct","subj":"T5881","obj":"T5872"},{"id":"R3843","pred":"punct","subj":"T5882","obj":"T5835"},{"id":"R3844","pred":"advmod","subj":"T5884","obj":"T5885"},{"id":"R3845","pred":"nsubj","subj":"T5885","obj":"T5888"},{"id":"R3846","pred":"det","subj":"T5886","obj":"T5885"},{"id":"R3847","pred":"amod","subj":"T5887","obj":"T5885"},{"id":"R3848","pred":"prep","subj":"T5889","obj":"T5885"},{"id":"R3849","pred":"nmod","subj":"T5890","obj":"T5891"},{"id":"R3850","pred":"pobj","subj":"T5891","obj":"T5889"},{"id":"R3851","pred":"punct","subj":"T5892","obj":"T5890"},{"id":"R3852","pred":"nummod","subj":"T5893","obj":"T5890"},{"id":"R3853","pred":"compound","subj":"T5894","obj":"T5891"},{"id":"R3854","pred":"prep","subj":"T5895","obj":"T5885"},{"id":"R3855","pred":"pobj","subj":"T5896","obj":"T5895"},{"id":"R3856","pred":"prep","subj":"T5897","obj":"T5896"},{"id":"R3857","pred":"det","subj":"T5898","obj":"T5899"},{"id":"R3858","pred":"pobj","subj":"T5899","obj":"T5897"},{"id":"R3859","pred":"prep","subj":"T5900","obj":"T5899"},{"id":"R3860","pred":"amod","subj":"T5901","obj":"T5902"},{"id":"R3861","pred":"amod","subj":"T5902","obj":"T5904"},{"id":"R3862","pred":"punct","subj":"T5903","obj":"T5902"},{"id":"R3863","pred":"pobj","subj":"T5904","obj":"T5900"},{"id":"R3864","pred":"prep","subj":"T5905","obj":"T5904"},{"id":"R3865","pred":"amod","subj":"T5906","obj":"T5907"},{"id":"R3866","pred":"pobj","subj":"T5907","obj":"T5905"},{"id":"R3867","pred":"det","subj":"T5908","obj":"T5909"},{"id":"R3868","pred":"dobj","subj":"T5909","obj":"T5888"},{"id":"R3869","pred":"amod","subj":"T5910","obj":"T5909"},{"id":"R3870","pred":"compound","subj":"T5911","obj":"T5909"},{"id":"R3871","pred":"prep","subj":"T5912","obj":"T5909"},{"id":"R3872","pred":"pobj","subj":"T5913","obj":"T5912"},{"id":"R3873","pred":"punct","subj":"T5914","obj":"T5913"},{"id":"R3874","pred":"nummod","subj":"T5915","obj":"T5913"},{"id":"R3875","pred":"prep","subj":"T5916","obj":"T5909"},{"id":"R3876","pred":"pobj","subj":"T5917","obj":"T5916"},{"id":"R3877","pred":"prep","subj":"T5918","obj":"T5917"},{"id":"R3878","pred":"det","subj":"T5919","obj":"T5920"},{"id":"R3879","pred":"pobj","subj":"T5920","obj":"T5918"},{"id":"R3880","pred":"amod","subj":"T5921","obj":"T5920"},{"id":"R3881","pred":"punct","subj":"T5922","obj":"T5923"},{"id":"R3882","pred":"parataxis","subj":"T5923","obj":"T5888"},{"id":"R3883","pred":"punct","subj":"T5924","obj":"T5923"},{"id":"R3884","pred":"punct","subj":"T5925","obj":"T5888"},{"id":"R3885","pred":"advmod","subj":"T5927","obj":"T5928"},{"id":"R3886","pred":"punct","subj":"T5929","obj":"T5928"},{"id":"R3887","pred":"det","subj":"T5930","obj":"T5931"},{"id":"R3888","pred":"nsubj","subj":"T5931","obj":"T5928"},{"id":"R3889","pred":"compound","subj":"T5932","obj":"T5931"},{"id":"R3890","pred":"prep","subj":"T5933","obj":"T5928"},{"id":"R3891","pred":"pobj","subj":"T5934","obj":"T5933"},{"id":"R3892","pred":"det","subj":"T5935","obj":"T5936"},{"id":"R3893","pred":"attr","subj":"T5936","obj":"T5928"},{"id":"R3894","pred":"amod","subj":"T5937","obj":"T5936"},{"id":"R3895","pred":"prep","subj":"T5938","obj":"T5936"},{"id":"R3896","pred":"det","subj":"T5939","obj":"T5940"},{"id":"R3897","pred":"pobj","subj":"T5940","obj":"T5938"},{"id":"R3898","pred":"amod","subj":"T5941","obj":"T5940"},{"id":"R3899","pred":"nmod","subj":"T5942","obj":"T5940"},{"id":"R3900","pred":"punct","subj":"T5943","obj":"T5942"},{"id":"R3901","pred":"nummod","subj":"T5944","obj":"T5942"},{"id":"R3902","pred":"compound","subj":"T5945","obj":"T5940"},{"id":"R3903","pred":"punct","subj":"T5946","obj":"T5928"},{"id":"R3904","pred":"cc","subj":"T5947","obj":"T5928"},{"id":"R3905","pred":"nummod","subj":"T5948","obj":"T5949"},{"id":"R3906","pred":"nsubjpass","subj":"T5949","obj":"T5955"},{"id":"R3907","pred":"npadvmod","subj":"T5950","obj":"T5951"},{"id":"R3908","pred":"amod","subj":"T5951","obj":"T5949"},{"id":"R3909","pred":"punct","subj":"T5952","obj":"T5951"},{"id":"R3910","pred":"compound","subj":"T5953","obj":"T5949"},{"id":"R3911","pred":"compound","subj":"T5954","obj":"T5949"},{"id":"R3912","pred":"conj","subj":"T5955","obj":"T5928"},{"id":"R3913","pred":"auxpass","subj":"T5956","obj":"T5955"},{"id":"R3914","pred":"advmod","subj":"T5957","obj":"T5955"},{"id":"R3915","pred":"punct","subj":"T5958","obj":"T5955"}],"text":"For all MTF-1 target genes characterized so far, such as Mt1, Mt2 and Znt1, MTF-1 exerts its transcriptional activation activity via standard MRE sequences located proximal to the transcription start (4,5,8,18,19). Even a specific search for MTF-1 binding sites by selection from a pool of double-stranded oligonucleotides with random sequences yielded no new binding motif for MTF-1 in addition to the known MREs (34). Thus, an MRE sequence is to date the only indication for a direct MTF-1 target gene, and four MRE-containing target gene candidates were further analyzed."}
2_test
{"project":"2_test","denotations":[{"id":"16221973-8026472-77403425","span":{"begin":201,"end":202},"obj":"8026472"},{"id":"16221973-8824273-77403426","span":{"begin":203,"end":204},"obj":"8824273"},{"id":"16221973-6095286-77403427","span":{"begin":205,"end":206},"obj":"6095286"},{"id":"16221973-10096565-77403428","span":{"begin":207,"end":209},"obj":"10096565"},{"id":"16221973-10952993-77403429","span":{"begin":210,"end":212},"obj":"10952993"},{"id":"16221973-15318811-77403430","span":{"begin":415,"end":417},"obj":"15318811"}],"text":"For all MTF-1 target genes characterized so far, such as Mt1, Mt2 and Znt1, MTF-1 exerts its transcriptional activation activity via standard MRE sequences located proximal to the transcription start (4,5,8,18,19). Even a specific search for MTF-1 binding sites by selection from a pool of double-stranded oligonucleotides with random sequences yielded no new binding motif for MTF-1 in addition to the known MREs (34). Thus, an MRE sequence is to date the only indication for a direct MTF-1 target gene, and four MRE-containing target gene candidates were further analyzed."}
craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T5203","span":{"begin":8,"end":13},"obj":"PR:000010717"},{"id":"T5204","span":{"begin":21,"end":26},"obj":"SO:0000704"},{"id":"T5205","span":{"begin":57,"end":60},"obj":"PR:000010925"},{"id":"T5206","span":{"begin":62,"end":65},"obj":"PR:000010704"},{"id":"T5207","span":{"begin":70,"end":74},"obj":"PR:000015073"},{"id":"T5208","span":{"begin":76,"end":81},"obj":"PR:000010717"},{"id":"T5209","span":{"begin":242,"end":247},"obj":"PR:000010717"},{"id":"T5210","span":{"begin":248,"end":261},"obj":"SO:0000409"},{"id":"T5211","span":{"begin":290,"end":322},"obj":"SO:0000442"},{"id":"T5212","span":{"begin":378,"end":383},"obj":"PR:000010717"},{"id":"T5213","span":{"begin":486,"end":491},"obj":"PR:000010717"},{"id":"T5214","span":{"begin":499,"end":503},"obj":"SO:0000704"},{"id":"T5215","span":{"begin":536,"end":540},"obj":"SO:0000704"}],"text":"For all MTF-1 target genes characterized so far, such as Mt1, Mt2 and Znt1, MTF-1 exerts its transcriptional activation activity via standard MRE sequences located proximal to the transcription start (4,5,8,18,19). Even a specific search for MTF-1 binding sites by selection from a pool of double-stranded oligonucleotides with random sequences yielded no new binding motif for MTF-1 in addition to the known MREs (34). Thus, an MRE sequence is to date the only indication for a direct MTF-1 target gene, and four MRE-containing target gene candidates were further analyzed."}
craft-ca-core-ex-dev
{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T5315","span":{"begin":8,"end":13},"obj":"PR_EXT:000010717"},{"id":"T5316","span":{"begin":21,"end":26},"obj":"SO_EXT:0000704"},{"id":"T5317","span":{"begin":57,"end":60},"obj":"PR_EXT:000010925"},{"id":"T5318","span":{"begin":62,"end":65},"obj":"PR_EXT:000010704"},{"id":"T5319","span":{"begin":70,"end":74},"obj":"PR_EXT:000015073"},{"id":"T5320","span":{"begin":76,"end":81},"obj":"PR_EXT:000010717"},{"id":"T5321","span":{"begin":93,"end":108},"obj":"GO_EXT:transcription"},{"id":"T5322","span":{"begin":146,"end":155},"obj":"SO_EXT:biological_sequence"},{"id":"T5323","span":{"begin":180,"end":199},"obj":"GO_SO_EXT:transcriptional_start_entity_or_process"},{"id":"T5324","span":{"begin":242,"end":247},"obj":"PR_EXT:000010717"},{"id":"T5325","span":{"begin":248,"end":255},"obj":"CHEMINF_GO_EXT:chemical_binding_or_bond_formation"},{"id":"T5326","span":{"begin":248,"end":261},"obj":"SO_EXT:0000409"},{"id":"T5327","span":{"begin":290,"end":322},"obj":"SO_EXT:0000442"},{"id":"T5328","span":{"begin":306,"end":322},"obj":"CHEBI_SO_EXT:oligonucleotide"},{"id":"T5329","span":{"begin":335,"end":344},"obj":"SO_EXT:biological_sequence"},{"id":"T5330","span":{"begin":360,"end":367},"obj":"CHEMINF_GO_EXT:chemical_binding_or_bond_formation"},{"id":"T5331","span":{"begin":368,"end":373},"obj":"SO_EXT:sequence_or_structure_motif"},{"id":"T5332","span":{"begin":378,"end":383},"obj":"PR_EXT:000010717"},{"id":"T5333","span":{"begin":433,"end":441},"obj":"SO_EXT:biological_sequence"},{"id":"T5334","span":{"begin":486,"end":491},"obj":"PR_EXT:000010717"},{"id":"T5335","span":{"begin":499,"end":503},"obj":"SO_EXT:0000704"},{"id":"T5336","span":{"begin":536,"end":540},"obj":"SO_EXT:0000704"}],"text":"For all MTF-1 target genes characterized so far, such as Mt1, Mt2 and Znt1, MTF-1 exerts its transcriptional activation activity via standard MRE sequences located proximal to the transcription start (4,5,8,18,19). Even a specific search for MTF-1 binding sites by selection from a pool of double-stranded oligonucleotides with random sequences yielded no new binding motif for MTF-1 in addition to the known MREs (34). Thus, an MRE sequence is to date the only indication for a direct MTF-1 target gene, and four MRE-containing target gene candidates were further analyzed."}