PMC:1253828 / 1840-38092 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T980	13-16	DT	denotes	All
T981	17-26	NNS	denotes	organisms
T982	32-39	VBN	denotes	evolved
T983	27-31	VBP	denotes	have
T984	40-50	NNS	denotes	mechanisms
T985	51-53	TO	denotes	to
T986	54-58	VB	denotes	cope
T987	59-63	IN	denotes	with
T988	64-65	DT	denotes	a
T989	66-73	NN	denotes	variety
T990	74-76	IN	denotes	of
T991	77-83	NN	denotes	stress
T992	84-94	NNS	denotes	situations
T993	94-95	.	denotes	.
T994	95-304	sentence	denotes	One type of stress response is triggered by heavy metals, such as zinc, copper and cadmium (for convenience, the terms zinc, copper and cadmium are also used here to denote Zn2+, Cu2+ and Cd2+, respectively).
T995	96-99	CD	denotes	One
T996	100-104	NN	denotes	type
T997	127-136	VBN	denotes	triggered
T998	105-107	IN	denotes	of
T999	108-114	NN	denotes	stress
T1000	115-123	NN	denotes	response
T1001	124-126	VBZ	denotes	is
T1002	137-139	IN	denotes	by
T1003	140-145	JJ	denotes	heavy
T1004	146-152	NNS	denotes	metals
T1005	152-154	,	denotes	,
T1006	154-158	JJ	denotes	such
T1007	159-161	IN	denotes	as
T1008	162-166	NN	denotes	zinc
T1009	166-168	,	denotes	,
T1010	168-174	NN	denotes	copper
T1011	175-178	CC	denotes	and
T1012	179-186	NN	denotes	cadmium
T1013	187-188	-LRB-	denotes	(
T1014	249-253	VBN	denotes	used
T1015	188-191	IN	denotes	for
T1016	192-203	NN	denotes	convenience
T1017	203-205	,	denotes	,
T1018	205-208	DT	denotes	the
T1019	215-219	NN	denotes	zinc
T1020	209-214	NNS	denotes	terms
T1021	219-221	,	denotes	,
T1022	221-227	NN	denotes	copper
T1023	228-231	CC	denotes	and
T1024	232-239	NN	denotes	cadmium
T1025	240-243	VBP	denotes	are
T1026	244-248	RB	denotes	also
T1027	254-258	RB	denotes	here
T1028	259-261	TO	denotes	to
T1029	262-268	VB	denotes	denote
T1030	269-272	NN	denotes	Zn2
T1031	272-273	SYM	denotes	+
T1032	273-275	,	denotes	,
T1033	275-278	NN	denotes	Cu2
T1034	278-279	SYM	denotes	+
T1035	280-283	CC	denotes	and
T1036	284-287	NN	denotes	Cd2
T1037	287-288	SYM	denotes	+
T1038	288-290	,	denotes	,
T1039	290-302	RB	denotes	respectively
T1040	302-303	-RRB-	denotes	)
T1041	303-304	.	denotes	.
T1042	304-485	sentence	denotes	Metallothioneins (MTs), small, cysteine-rich proteins, play an important role in metal homeostasis and detoxification due to their ability to bind different heavy metal ions (1–3).
T1043	305-321	NNS	denotes	Metallothioneins
T1044	360-364	VBP	denotes	play
T1045	322-323	-LRB-	denotes	(
T1046	323-326	NNS	denotes	MTs
T1047	326-327	-RRB-	denotes	)
T1048	327-329	,	denotes	,
T1049	329-334	JJ	denotes	small
T1050	350-358	NN	denotes	proteins
T1051	334-336	,	denotes	,
T1052	336-344	NN	denotes	cysteine
T1053	345-349	JJ	denotes	rich
T1054	344-345	HYPH	denotes	-
T1055	358-360	,	denotes	,
T1056	365-367	DT	denotes	an
T1057	378-382	NN	denotes	role
T1058	368-377	JJ	denotes	important
T1059	383-385	IN	denotes	in
T1060	386-391	NN	denotes	metal
T1061	392-403	NN	denotes	homeostasis
T1062	404-407	CC	denotes	and
T1063	408-422	NN	denotes	detoxification
T1064	423-426	IN	denotes	due
T1065	427-429	IN	denotes	to
T1066	430-435	PRP$	denotes	their
T1067	436-443	NN	denotes	ability
T1068	444-446	TO	denotes	to
T1069	447-451	VB	denotes	bind
T1070	452-461	JJ	denotes	different
T1071	474-478	NNS	denotes	ions
T1072	462-467	JJ	denotes	heavy
T1073	468-473	NN	denotes	metal
T1074	479-480	-LRB-	denotes	(
T1075	480-481	CD	denotes	1
T1076	481-482	SYM	denotes	–
T1077	482-483	CD	denotes	3
T1078	483-484	-RRB-	denotes	)
T1079	484-485	.	denotes	.
T1080	485-563	sentence	denotes	In the mouse, there are four metallothionein genes, designated as Mt1 to Mt4.
T1081	486-488	IN	denotes	In
T1082	506-509	VBP	denotes	are
T1083	489-492	DT	denotes	the
T1084	493-498	NN	denotes	mouse
T1085	498-500	,	denotes	,
T1086	500-505	EX	denotes	there
T1087	510-514	CD	denotes	four
T1088	531-536	NNS	denotes	genes
T1089	515-530	NN	denotes	metallothionein
T1090	536-538	,	denotes	,
T1091	538-548	VBN	denotes	designated
T1092	549-551	IN	denotes	as
T1093	552-555	NN	denotes	Mt1
T1094	556-558	IN	denotes	to
T1095	559-562	NN	denotes	Mt4
T1096	562-563	.	denotes	.
T1097	563-698	sentence	denotes	Basal, as well as heavy metal-induced, expression of Mt1 and Mt2 is mediated by metal-responsive transcription factor 1 (MTF-1) (4–7).
T1098	564-569	JJ	denotes	Basal
T1099	603-613	NN	denotes	expression
T1100	569-571	,	denotes	,
T1101	571-573	RB	denotes	as
T1102	579-581	IN	denotes	as
T1103	574-578	RB	denotes	well
T1104	582-587	JJ	denotes	heavy
T1105	588-593	NN	denotes	metal
T1106	594-601	VBN	denotes	induced
T1107	593-594	HYPH	denotes	-
T1108	601-603	,	denotes	,
T1109	632-640	VBN	denotes	mediated
T1110	614-616	IN	denotes	of
T1111	617-620	NN	denotes	Mt1
T1112	621-624	CC	denotes	and
T1113	625-628	NN	denotes	Mt2
T1114	629-631	VBZ	denotes	is
T1115	641-643	IN	denotes	by
T1116	644-649	NN	denotes	metal
T1117	650-660	JJ	denotes	responsive
T1118	649-650	HYPH	denotes	-
T1119	675-681	NN	denotes	factor
T1120	661-674	NN	denotes	transcription
T1121	682-683	CD	denotes	1
T1122	684-685	-LRB-	denotes	(
T1123	685-688	NN	denotes	MTF
T1124	688-689	HYPH	denotes	-
T1125	689-690	CD	denotes	1
T1126	690-691	-RRB-	denotes	)
T1127	692-693	-LRB-	denotes	(
T1128	693-694	CD	denotes	4
T1129	694-695	SYM	denotes	–
T1130	695-696	CD	denotes	7
T1131	696-697	-RRB-	denotes	)
T1132	697-698	.	denotes	.
T1133	698-896	sentence	denotes	This zinc finger protein recognizes short cis-acting DNA sequences, termed metal response elements (MREs; core consensus sequence TGCRCNC), which are present in the promoters of target genes (8,9).
T1134	699-703	DT	denotes	This
T1135	716-723	NN	denotes	protein
T1136	704-708	NN	denotes	zinc
T1137	709-715	NN	denotes	finger
T1138	724-734	VBZ	denotes	recognizes
T1139	735-740	JJ	denotes	short
T1140	756-765	NNS	denotes	sequences
T1141	741-744	NN	denotes	cis
T1142	745-751	VBG	denotes	acting
T1143	744-745	HYPH	denotes	-
T1144	752-755	NN	denotes	DNA
T1145	765-767	,	denotes	,
T1146	767-773	VBN	denotes	termed
T1147	774-779	NN	denotes	metal
T1148	789-797	NNS	denotes	elements
T1149	780-788	NN	denotes	response
T1150	798-799	-LRB-	denotes	(
T1151	799-803	NNS	denotes	MREs
T1152	803-804	:	denotes	;
T1153	829-836	NN	denotes	TGCRCNC
T1154	805-809	NN	denotes	core
T1155	810-819	NN	denotes	consensus
T1156	820-828	NN	denotes	sequence
T1157	836-837	-RRB-	denotes	)
T1158	837-839	,	denotes	,
T1159	839-844	WDT	denotes	which
T1160	845-848	VBP	denotes	are
T1161	849-856	JJ	denotes	present
T1162	857-859	IN	denotes	in
T1163	860-863	DT	denotes	the
T1164	864-873	NNS	denotes	promoters
T1165	874-876	IN	denotes	of
T1166	877-883	NN	denotes	target
T1167	884-889	NNS	denotes	genes
T1168	890-891	-LRB-	denotes	(
T1169	893-894	CD	denotes	9
T1170	891-892	CD	denotes	8
T1171	892-893	,	denotes	,
T1172	894-895	-RRB-	denotes	)
T1173	895-896	.	denotes	.
T1174	896-1035	sentence	denotes	MTF-1 is conserved in evolution, and homologs have been characterized in the mouse (10), humans (11), Drosophila (12–14) and fish (15,16).
T1175	897-900	NN	denotes	MTF
T1176	906-915	VBN	denotes	conserved
T1177	900-901	HYPH	denotes	-
T1178	901-902	CD	denotes	1
T1179	903-905	VBZ	denotes	is
T1180	916-918	IN	denotes	in
T1181	919-928	NN	denotes	evolution
T1182	928-930	,	denotes	,
T1183	930-933	CC	denotes	and
T1184	934-942	NNS	denotes	homologs
T1185	953-966	VBN	denotes	characterized
T1186	943-947	VBP	denotes	have
T1187	948-952	VBN	denotes	been
T1188	967-969	IN	denotes	in
T1189	970-973	DT	denotes	the
T1190	974-979	NN	denotes	mouse
T1191	980-981	-LRB-	denotes	(
T1192	981-983	CD	denotes	10
T1193	983-984	-RRB-	denotes	)
T1194	984-986	,	denotes	,
T1195	986-992	NNS	denotes	humans
T1196	993-994	-LRB-	denotes	(
T1197	994-996	CD	denotes	11
T1198	996-997	-RRB-	denotes	)
T1199	997-999	,	denotes	,
T1200	999-1009	NNP	denotes	Drosophila
T1201	1010-1011	-LRB-	denotes	(
T1202	1011-1013	CD	denotes	12
T1203	1013-1014	SYM	denotes	–
T1204	1014-1016	CD	denotes	14
T1205	1016-1017	-RRB-	denotes	)
T1206	1018-1021	CC	denotes	and
T1207	1022-1026	NN	denotes	fish
T1208	1027-1028	-LRB-	denotes	(
T1209	1031-1033	CD	denotes	16
T1210	1028-1030	CD	denotes	15
T1211	1030-1031	,	denotes	,
T1212	1033-1034	-RRB-	denotes	)
T1213	1034-1035	.	denotes	.
T1214	1035-1101	sentence	denotes	The role of MTF-1 has been studied most extensively in the mouse.
T1215	1036-1039	DT	denotes	The
T1216	1040-1044	NN	denotes	role
T1217	1063-1070	VBN	denotes	studied
T1218	1045-1047	IN	denotes	of
T1219	1048-1051	NN	denotes	MTF
T1220	1051-1052	HYPH	denotes	-
T1221	1052-1053	CD	denotes	1
T1222	1054-1057	VBZ	denotes	has
T1223	1058-1062	VBN	denotes	been
T1224	1071-1075	RBS	denotes	most
T1225	1076-1087	RB	denotes	extensively
T1226	1088-1090	IN	denotes	in
T1227	1091-1094	DT	denotes	the
T1228	1095-1100	NN	denotes	mouse
T1229	1100-1101	.	denotes	.
T1230	1101-1278	sentence	denotes	Besides coping with heavy metal load, MTF-1 can also mediate the induction of Mt genes in response to other stress situations, such as oxidative stress (5,17) and hypoxia (18).
T1231	1102-1109	IN	denotes	Besides
T1232	1155-1162	VB	denotes	mediate
T1233	1110-1116	VBG	denotes	coping
T1234	1117-1121	IN	denotes	with
T1235	1122-1127	JJ	denotes	heavy
T1236	1128-1133	NN	denotes	metal
T1237	1134-1138	NN	denotes	load
T1238	1138-1140	,	denotes	,
T1239	1140-1143	NN	denotes	MTF
T1240	1143-1144	HYPH	denotes	-
T1241	1144-1145	CD	denotes	1
T1242	1146-1149	MD	denotes	can
T1243	1150-1154	RB	denotes	also
T1244	1163-1166	DT	denotes	the
T1245	1167-1176	NN	denotes	induction
T1246	1177-1179	IN	denotes	of
T1247	1180-1182	NN	denotes	Mt
T1248	1183-1188	NNS	denotes	genes
T1249	1189-1191	IN	denotes	in
T1250	1192-1200	NN	denotes	response
T1251	1201-1203	IN	denotes	to
T1252	1204-1209	JJ	denotes	other
T1253	1217-1227	NNS	denotes	situations
T1254	1210-1216	NN	denotes	stress
T1255	1227-1229	,	denotes	,
T1256	1229-1233	JJ	denotes	such
T1257	1234-1236	IN	denotes	as
T1258	1237-1246	JJ	denotes	oxidative
T1259	1247-1253	NN	denotes	stress
T1260	1254-1255	-LRB-	denotes	(
T1261	1257-1259	CD	denotes	17
T1262	1255-1256	CD	denotes	5
T1263	1256-1257	,	denotes	,
T1264	1259-1260	-RRB-	denotes	)
T1265	1261-1264	CC	denotes	and
T1266	1265-1272	NN	denotes	hypoxia
T1267	1273-1274	-LRB-	denotes	(
T1268	1274-1276	CD	denotes	18
T1269	1276-1277	-RRB-	denotes	)
T1270	1277-1278	.	denotes	.
T1271	1278-1637	sentence	denotes	In addition, it is required for the metalloregulation of Znt1, encoding the major plasma membrane-localized zinc efflux transporter (19), the hypoxic/anoxic induction of the gene for placental growth factor (Plgf), an angiogenic protein of the vascular endothelial growth factor (VEGF) family (20), and has recently been invoked in tumor development (21,22).
T1272	1279-1281	IN	denotes	In
T1273	1298-1306	VBN	denotes	required
T1274	1282-1290	NN	denotes	addition
T1275	1290-1292	,	denotes	,
T1276	1292-1294	PRP	denotes	it
T1277	1295-1297	VBZ	denotes	is
T1278	1307-1310	IN	denotes	for
T1279	1311-1314	DT	denotes	the
T1280	1315-1332	NN	denotes	metalloregulation
T1281	1333-1335	IN	denotes	of
T1282	1336-1340	NN	denotes	Znt1
T1283	1340-1342	,	denotes	,
T1284	1342-1350	VBG	denotes	encoding
T1285	1351-1354	DT	denotes	the
T1286	1399-1410	NN	denotes	transporter
T1287	1355-1360	JJ	denotes	major
T1288	1361-1367	NN	denotes	plasma
T1289	1368-1376	NN	denotes	membrane
T1290	1377-1386	VBN	denotes	localized
T1291	1376-1377	HYPH	denotes	-
T1292	1387-1391	NN	denotes	zinc
T1293	1392-1398	NN	denotes	efflux
T1294	1411-1412	-LRB-	denotes	(
T1295	1412-1414	CD	denotes	19
T1296	1414-1415	-RRB-	denotes	)
T1297	1415-1417	,	denotes	,
T1298	1417-1420	DT	denotes	the
T1299	1436-1445	NN	denotes	induction
T1300	1421-1428	JJ	denotes	hypoxic
T1301	1429-1435	JJ	denotes	anoxic
T1302	1428-1429	HYPH	denotes	/
T1303	1446-1448	IN	denotes	of
T1304	1449-1452	DT	denotes	the
T1305	1453-1457	NN	denotes	gene
T1306	1458-1461	IN	denotes	for
T1307	1462-1471	JJ	denotes	placental
T1308	1479-1485	NN	denotes	factor
T1309	1472-1478	NN	denotes	growth
T1310	1486-1487	-LRB-	denotes	(
T1311	1487-1491	NN	denotes	Plgf
T1312	1491-1492	-RRB-	denotes	)
T1313	1492-1494	,	denotes	,
T1314	1494-1496	DT	denotes	an
T1315	1508-1515	NN	denotes	protein
T1316	1497-1507	JJ	denotes	angiogenic
T1317	1516-1518	IN	denotes	of
T1318	1519-1522	DT	denotes	the
T1319	1565-1571	NN	denotes	family
T1320	1523-1531	JJ	denotes	vascular
T1321	1551-1557	NN	denotes	factor
T1322	1532-1543	JJ	denotes	endothelial
T1323	1544-1550	NN	denotes	growth
T1324	1558-1559	-LRB-	denotes	(
T1325	1559-1563	NN	denotes	VEGF
T1326	1563-1564	-RRB-	denotes	)
T1327	1572-1573	-LRB-	denotes	(
T1328	1573-1575	CD	denotes	20
T1329	1575-1576	-RRB-	denotes	)
T1330	1576-1578	,	denotes	,
T1331	1578-1581	CC	denotes	and
T1332	1582-1585	VBZ	denotes	has
T1333	1600-1607	VBN	denotes	invoked
T1334	1586-1594	RB	denotes	recently
T1335	1595-1599	VBN	denotes	been
T1336	1608-1610	IN	denotes	in
T1337	1611-1616	NN	denotes	tumor
T1338	1617-1628	NN	denotes	development
T1339	1629-1630	-LRB-	denotes	(
T1340	1633-1635	CD	denotes	22
T1341	1630-1632	CD	denotes	21
T1342	1632-1633	,	denotes	,
T1343	1635-1636	-RRB-	denotes	)
T1344	1636-1637	.	denotes	.
T1345	1637-1823	sentence	denotes	Furthermore, MTF-1 has an essential function during embryogenesis: targeted disruption of Mtf1 results in embryonic lethality around 14 days post coitum due to hepatocyte necrosis (23).
T1346	1638-1649	RB	denotes	Furthermore
T1347	1657-1660	VBZ	denotes	has
T1348	1649-1651	,	denotes	,
T1349	1651-1654	NN	denotes	MTF
T1350	1654-1655	HYPH	denotes	-
T1351	1655-1656	CD	denotes	1
T1352	1733-1740	VBZ	denotes	results
T1353	1661-1663	DT	denotes	an
T1354	1674-1682	NN	denotes	function
T1355	1664-1673	JJ	denotes	essential
T1356	1683-1689	IN	denotes	during
T1357	1690-1703	NN	denotes	embryogenesis
T1358	1703-1705	:	denotes	:
T1359	1705-1713	VBN	denotes	targeted
T1360	1714-1724	NN	denotes	disruption
T1361	1725-1727	IN	denotes	of
T1362	1728-1732	NN	denotes	Mtf1
T1363	1741-1743	IN	denotes	in
T1364	1744-1753	JJ	denotes	embryonic
T1365	1754-1763	NN	denotes	lethality
T1366	1764-1770	IN	denotes	around
T1367	1771-1773	CD	denotes	14
T1368	1774-1778	NNS	denotes	days
T1369	1779-1783	FW	denotes	post
T1370	1784-1790	FW	denotes	coitum
T1371	1791-1794	IN	denotes	due
T1372	1795-1797	IN	denotes	to
T1373	1798-1808	NN	denotes	hepatocyte
T1374	1809-1817	NN	denotes	necrosis
T1375	1818-1819	-LRB-	denotes	(
T1376	1819-1821	CD	denotes	23
T1377	1821-1822	-RRB-	denotes	)
T1378	1822-1823	.	denotes	.
T1379	1823-2065	sentence	denotes	In contrast, mice with null mutations for the stress-inducible metallothionein genes (Mt1 and Mt2) are viable, though sensitive to cadmium (24,25), indicating that additional important MTF-1 target genes are involved in the lethal phenotype.
T1380	1824-1826	IN	denotes	In
T1381	1923-1926	VBP	denotes	are
T1382	1827-1835	NN	denotes	contrast
T1383	1835-1837	,	denotes	,
T1384	1837-1841	NNS	denotes	mice
T1385	1842-1846	IN	denotes	with
T1386	1847-1851	JJ	denotes	null
T1387	1852-1861	NNS	denotes	mutations
T1388	1862-1865	IN	denotes	for
T1389	1866-1869	DT	denotes	the
T1390	1903-1908	NNS	denotes	genes
T1391	1870-1876	NN	denotes	stress
T1392	1877-1886	JJ	denotes	inducible
T1393	1876-1877	HYPH	denotes	-
T1394	1887-1902	NN	denotes	metallothionein
T1395	1909-1910	-LRB-	denotes	(
T1396	1910-1913	NN	denotes	Mt1
T1397	1914-1917	CC	denotes	and
T1398	1918-1921	NN	denotes	Mt2
T1399	1921-1922	-RRB-	denotes	)
T1400	1927-1933	JJ	denotes	viable
T1401	1933-1935	,	denotes	,
T1402	1935-1941	IN	denotes	though
T1403	1942-1951	JJ	denotes	sensitive
T1404	1952-1954	IN	denotes	to
T1405	1955-1962	NN	denotes	cadmium
T1406	1963-1964	-LRB-	denotes	(
T1407	1967-1969	CD	denotes	25
T1408	1964-1966	CD	denotes	24
T1409	1966-1967	,	denotes	,
T1410	1969-1970	-RRB-	denotes	)
T1411	1970-1972	,	denotes	,
T1412	1972-1982	VBG	denotes	indicating
T1413	1983-1987	IN	denotes	that
T1414	2032-2040	VBN	denotes	involved
T1415	1988-1998	JJ	denotes	additional
T1416	2022-2027	NNS	denotes	genes
T1417	1999-2008	JJ	denotes	important
T1418	2009-2012	NN	denotes	MTF
T1419	2012-2013	HYPH	denotes	-
T1420	2013-2014	CD	denotes	1
T1421	2015-2021	NN	denotes	target
T1422	2028-2031	VBP	denotes	are
T1423	2041-2043	IN	denotes	in
T1424	2044-2047	DT	denotes	the
T1425	2055-2064	NN	denotes	phenotype
T1426	2048-2054	JJ	denotes	lethal
T1427	2064-2065	.	denotes	.
T1428	2065-2211	sentence	denotes	With the Cre-loxP conditional knockout technique, it is possible to circumvent the embryonic lethal phenotype of conventional Mtf1 knockout mice.
T1429	2066-2070	IN	denotes	With
T1430	2119-2121	VBZ	denotes	is
T1431	2071-2074	DT	denotes	the
T1432	2105-2114	NN	denotes	technique
T1433	2075-2078	NN	denotes	Cre
T1434	2079-2083	NN	denotes	loxP
T1435	2078-2079	HYPH	denotes	-
T1436	2084-2095	JJ	denotes	conditional
T1437	2096-2104	NN	denotes	knockout
T1438	2114-2116	,	denotes	,
T1439	2116-2118	PRP	denotes	it
T1440	2122-2130	JJ	denotes	possible
T1441	2131-2133	TO	denotes	to
T1442	2134-2144	VB	denotes	circumvent
T1443	2145-2148	DT	denotes	the
T1444	2166-2175	NN	denotes	phenotype
T1445	2149-2158	JJ	denotes	embryonic
T1446	2159-2165	JJ	denotes	lethal
T1447	2176-2178	IN	denotes	of
T1448	2179-2191	JJ	denotes	conventional
T1449	2206-2210	NNS	denotes	mice
T1450	2192-2196	NN	denotes	Mtf1
T1451	2197-2205	NN	denotes	knockout
T1452	2210-2211	.	denotes	.
T1453	2211-2364	sentence	denotes	Previous experiments with this technique revealed that deletion of Mtf1 from the liver after birth is no longer lethal under non-stress conditions (26).
T1454	2212-2220	JJ	denotes	Previous
T1455	2221-2232	NNS	denotes	experiments
T1456	2253-2261	VBD	denotes	revealed
T1457	2233-2237	IN	denotes	with
T1458	2238-2242	DT	denotes	this
T1459	2243-2252	NN	denotes	technique
T1460	2262-2266	IN	denotes	that
T1461	2311-2313	VBZ	denotes	is
T1462	2267-2275	NN	denotes	deletion
T1463	2276-2278	IN	denotes	of
T1464	2279-2283	NN	denotes	Mtf1
T1465	2284-2288	IN	denotes	from
T1466	2289-2292	DT	denotes	the
T1467	2293-2298	NN	denotes	liver
T1468	2299-2304	IN	denotes	after
T1469	2305-2310	NN	denotes	birth
T1470	2314-2316	RB	denotes	no
T1471	2317-2323	RB	denotes	longer
T1472	2324-2330	JJ	denotes	lethal
T1473	2331-2336	IN	denotes	under
T1474	2337-2347	JJ	denotes	non-stress
T1475	2348-2358	NNS	denotes	conditions
T1476	2359-2360	-LRB-	denotes	(
T1477	2360-2362	CD	denotes	26
T1478	2362-2363	-RRB-	denotes	)
T1479	2363-2364	.	denotes	.
T1480	2364-2539	sentence	denotes	For this study, an inducible, liver-specific Mtf1 knockout mouse line was generated to perform a search for MTF-1 target genes and cadmium-inducible genes in the adult liver.
T1481	2365-2368	IN	denotes	For
T1482	2439-2448	VBN	denotes	generated
T1483	2369-2373	DT	denotes	this
T1484	2374-2379	NN	denotes	study
T1485	2379-2381	,	denotes	,
T1486	2381-2383	DT	denotes	an
T1487	2430-2434	NN	denotes	line
T1488	2384-2393	JJ	denotes	inducible
T1489	2393-2395	,	denotes	,
T1490	2395-2400	NN	denotes	liver
T1491	2401-2409	JJ	denotes	specific
T1492	2400-2401	HYPH	denotes	-
T1493	2410-2414	NN	denotes	Mtf1
T1494	2415-2423	NN	denotes	knockout
T1495	2424-2429	NN	denotes	mouse
T1496	2435-2438	VBD	denotes	was
T1497	2449-2451	TO	denotes	to
T1498	2452-2459	VB	denotes	perform
T1499	2460-2461	DT	denotes	a
T1500	2462-2468	NN	denotes	search
T1501	2469-2472	IN	denotes	for
T1502	2473-2476	NN	denotes	MTF
T1503	2486-2491	NNS	denotes	genes
T1504	2476-2477	HYPH	denotes	-
T1505	2477-2478	CD	denotes	1
T1506	2479-2485	NN	denotes	target
T1507	2492-2495	CC	denotes	and
T1508	2496-2503	NN	denotes	cadmium
T1509	2504-2513	JJ	denotes	inducible
T1510	2503-2504	HYPH	denotes	-
T1511	2514-2519	NNS	denotes	genes
T1512	2520-2522	IN	denotes	in
T1513	2523-2526	DT	denotes	the
T1514	2533-2538	NN	denotes	liver
T1515	2527-2532	JJ	denotes	adult
T1516	2538-2539	.	denotes	.
T1517	2539-2760	sentence	denotes	A number of target gene candidates emerged upon a transcriptome analysis of mock- and cadmium-treated Mtf1 conditional knockout mice and control littermates and several of these were confirmed by semiquantitative RT–PCR.
T1518	2540-2541	DT	denotes	A
T1519	2542-2548	NN	denotes	number
T1520	2575-2582	VBD	denotes	emerged
T1521	2549-2551	IN	denotes	of
T1522	2552-2558	NN	denotes	target
T1523	2559-2563	NN	denotes	gene
T1524	2564-2574	NNS	denotes	candidates
T1525	2583-2587	IN	denotes	upon
T1526	2588-2589	DT	denotes	a
T1527	2604-2612	NN	denotes	analysis
T1528	2590-2603	NN	denotes	transcriptome
T1529	2613-2615	IN	denotes	of
T1530	2616-2620	JJ	denotes	mock
T1531	2634-2641	VBN	denotes	treated
T1532	2620-2621	HYPH	denotes	-
T1533	2622-2625	CC	denotes	and
T1534	2626-2633	NN	denotes	cadmium
T1535	2633-2634	HYPH	denotes	-
T1536	2668-2672	NNS	denotes	mice
T1537	2642-2646	NN	denotes	Mtf1
T1538	2647-2658	JJ	denotes	conditional
T1539	2659-2667	NN	denotes	knockout
T1540	2673-2676	CC	denotes	and
T1541	2677-2684	NN	denotes	control
T1542	2685-2696	NNS	denotes	littermates
T1543	2697-2700	CC	denotes	and
T1544	2701-2708	JJ	denotes	several
T1545	2723-2732	VBN	denotes	confirmed
T1546	2709-2711	IN	denotes	of
T1547	2712-2717	DT	denotes	these
T1548	2718-2722	VBD	denotes	were
T1549	2733-2735	IN	denotes	by
T1550	2736-2752	JJ	denotes	semiquantitative
T1551	2756-2759	NN	denotes	PCR
T1552	2753-2755	NN	denotes	RT
T1553	2755-2756	HYPH	denotes	–
T1554	2759-2760	.	denotes	.
T1555	2760-3125	sentence	denotes	Besides the stress-inducible metallothionein genes that were already known as target genes of MTF-1, we find that MTF-1 is important for basal liver expression of the gene for selenoprotein W, muscle 1 (Sepw1) as well as for cadmium-induced expression of N-myc downstream regulated gene 1 (Ndrg1) and the gene encoding cysteine- and glycine-rich protein 1 (Csrp1).
T1556	2761-2768	IN	denotes	Besides
T1557	2865-2869	VBP	denotes	find
T1558	2769-2772	DT	denotes	the
T1559	2806-2811	NNS	denotes	genes
T1560	2773-2779	NN	denotes	stress
T1561	2780-2789	JJ	denotes	inducible
T1562	2779-2780	HYPH	denotes	-
T1563	2790-2805	NN	denotes	metallothionein
T1564	2812-2816	WDT	denotes	that
T1565	2830-2835	VBN	denotes	known
T1566	2817-2821	VBD	denotes	were
T1567	2822-2829	RB	denotes	already
T1568	2836-2838	IN	denotes	as
T1569	2839-2845	NN	denotes	target
T1570	2846-2851	NNS	denotes	genes
T1571	2852-2854	IN	denotes	of
T1572	2855-2858	NN	denotes	MTF
T1573	2858-2859	HYPH	denotes	-
T1574	2859-2860	CD	denotes	1
T1575	2860-2862	,	denotes	,
T1576	2862-2864	PRP	denotes	we
T1577	2870-2874	IN	denotes	that
T1578	2881-2883	VBZ	denotes	is
T1579	2875-2878	NN	denotes	MTF
T1580	2878-2879	HYPH	denotes	-
T1581	2879-2880	CD	denotes	1
T1582	2884-2893	JJ	denotes	important
T1583	2894-2897	IN	denotes	for
T1584	2898-2903	JJ	denotes	basal
T1585	2910-2920	NN	denotes	expression
T1586	2904-2909	NN	denotes	liver
T1587	2921-2923	IN	denotes	of
T1588	2924-2927	DT	denotes	the
T1589	2928-2932	NN	denotes	gene
T1590	2933-2936	IN	denotes	for
T1591	2937-2950	NN	denotes	selenoprotein
T1592	2954-2960	NN	denotes	muscle
T1593	2951-2952	NN	denotes	W
T1594	2952-2954	,	denotes	,
T1595	2961-2962	CD	denotes	1
T1596	2963-2964	-LRB-	denotes	(
T1597	2964-2969	NN	denotes	Sepw1
T1598	2969-2970	-RRB-	denotes	)
T1599	2971-2973	RB	denotes	as
T1600	2979-2981	IN	denotes	as
T1601	2974-2978	RB	denotes	well
T1602	2982-2985	IN	denotes	for
T1603	2986-2993	NN	denotes	cadmium
T1604	2994-3001	VBN	denotes	induced
T1605	2993-2994	HYPH	denotes	-
T1606	3002-3012	NN	denotes	expression
T1607	3013-3015	IN	denotes	of
T1608	3016-3017	NN	denotes	N
T1609	3018-3021	NN	denotes	myc
T1610	3017-3018	HYPH	denotes	-
T1611	3043-3047	NN	denotes	gene
T1612	3022-3032	RB	denotes	downstream
T1613	3033-3042	VBN	denotes	regulated
T1614	3048-3049	CD	denotes	1
T1615	3050-3051	-LRB-	denotes	(
T1616	3051-3056	NN	denotes	Ndrg1
T1617	3056-3057	-RRB-	denotes	)
T1618	3058-3061	CC	denotes	and
T1619	3062-3065	DT	denotes	the
T1620	3066-3070	NN	denotes	gene
T1621	3071-3079	VBG	denotes	encoding
T1622	3080-3088	NN	denotes	cysteine
T1623	3102-3106	JJ	denotes	rich
T1624	3088-3089	HYPH	denotes	-
T1625	3090-3093	CC	denotes	and
T1626	3094-3101	NN	denotes	glycine
T1627	3101-3102	HYPH	denotes	-
T1628	3107-3114	NN	denotes	protein
T1629	3115-3116	CD	denotes	1
T1630	3117-3118	-LRB-	denotes	(
T1631	3118-3123	NN	denotes	Csrp1
T1632	3123-3124	-RRB-	denotes	)
T1633	3124-3125	.	denotes	.
T1634	3125-3282	sentence	denotes	In addition, MTF-1 appears to repress the expression of solute carrier family 39, member 10 gene (Slc39a10), which encodes a putative metal ion transporter.
T1635	3126-3128	IN	denotes	In
T1636	3145-3152	VBZ	denotes	appears
T1637	3129-3137	NN	denotes	addition
T1638	3137-3139	,	denotes	,
T1639	3139-3142	NN	denotes	MTF
T1640	3142-3143	HYPH	denotes	-
T1641	3143-3144	CD	denotes	1
T1642	3153-3155	TO	denotes	to
T1643	3156-3163	VB	denotes	repress
T1644	3164-3167	DT	denotes	the
T1645	3168-3178	NN	denotes	expression
T1646	3179-3181	IN	denotes	of
T1647	3182-3188	NN	denotes	solute
T1648	3208-3214	NN	denotes	member
T1649	3189-3196	NN	denotes	carrier
T1650	3197-3203	NN	denotes	family
T1651	3204-3206	CD	denotes	39
T1652	3206-3208	,	denotes	,
T1653	3218-3222	NN	denotes	gene
T1654	3215-3217	CD	denotes	10
T1655	3223-3224	-LRB-	denotes	(
T1656	3224-3232	NN	denotes	Slc39a10
T1657	3232-3233	-RRB-	denotes	)
T1658	3233-3235	,	denotes	,
T1659	3235-3240	WDT	denotes	which
T1660	3241-3248	VBZ	denotes	encodes
T1661	3249-3250	DT	denotes	a
T1662	3270-3281	NN	denotes	transporter
T1663	3251-3259	JJ	denotes	putative
T1664	3260-3265	NN	denotes	metal
T1665	3266-3269	NN	denotes	ion
T1666	3281-3282	.	denotes	.
T1667	3282-3392	sentence	denotes	In an MTF-1-independent transcriptome response, several genes involved in glutathione metabolism are induced.
T1668	3283-3285	IN	denotes	In
T1669	3384-3391	VBN	denotes	induced
T1670	3286-3288	DT	denotes	an
T1671	3321-3329	NN	denotes	response
T1672	3289-3292	NN	denotes	MTF
T1673	3295-3306	JJ	denotes	independent
T1674	3292-3293	HYPH	denotes	-
T1675	3293-3294	CD	denotes	1
T1676	3294-3295	HYPH	denotes	-
T1677	3307-3320	NN	denotes	transcriptome
T1678	3329-3331	,	denotes	,
T1679	3331-3338	JJ	denotes	several
T1680	3339-3344	NNS	denotes	genes
T1681	3345-3353	VBN	denotes	involved
T1682	3354-3356	IN	denotes	in
T1683	3357-3368	NN	denotes	glutathione
T1684	3369-3379	NN	denotes	metabolism
T1685	3380-3383	VBP	denotes	are
T1686	3391-3392	.	denotes	.
T1687	3392-3543	sentence	denotes	Further studies confirmed a dual anti-cadmium defense, one via glutathione and another one via MTF-1 and its target genes, including metallothioneins.
T1688	3393-3400	JJ	denotes	Further
T1689	3401-3408	NNS	denotes	studies
T1690	3409-3418	VBD	denotes	confirmed
T1691	3419-3420	DT	denotes	a
T1692	3439-3446	NN	denotes	defense
T1693	3421-3425	JJ	denotes	dual
T1694	3426-3438	JJ	denotes	anti-cadmium
T1695	3446-3448	,	denotes	,
T1696	3448-3451	CD	denotes	one
T1697	3452-3455	IN	denotes	via
T1698	3456-3467	NN	denotes	glutathione
T1699	3468-3471	CC	denotes	and
T1700	3472-3479	DT	denotes	another
T1701	3480-3483	CD	denotes	one
T1702	3484-3487	IN	denotes	via
T1703	3488-3491	NN	denotes	MTF
T1704	3491-3492	HYPH	denotes	-
T1705	3492-3493	CD	denotes	1
T1706	3494-3497	CC	denotes	and
T1707	3498-3501	PRP$	denotes	its
T1708	3509-3514	NNS	denotes	genes
T1709	3502-3508	NN	denotes	target
T1710	3514-3516	,	denotes	,
T1711	3516-3525	VBG	denotes	including
T1712	3526-3542	NNS	denotes	metallothioneins
T1713	3542-3543	.	denotes	.
T1758	3568-3578	NN	denotes	Generation
T1759	3579-3581	IN	denotes	of
T1760	3582-3586	NN	denotes	Mtf1
T1761	3608-3612	NNS	denotes	mice
T1762	3587-3598	JJ	denotes	conditional
T1763	3599-3607	NN	denotes	knockout
T1764	3613-3616	CC	denotes	and
T1765	3617-3622	NN	denotes	liver
T1766	3623-3631	JJ	denotes	specific
T1767	3622-3623	HYPH	denotes	-
T1768	3632-3640	NN	denotes	deletion
T1769	3640-3745	sentence	denotes	Mtf1 conditional knockout mice were generated in collaboration with Dr Michael Leviten (San Carlos, CA).
T1770	3641-3645	NN	denotes	Mtf1
T1771	3667-3671	NNS	denotes	mice
T1772	3646-3657	JJ	denotes	conditional
T1773	3658-3666	NN	denotes	knockout
T1774	3677-3686	VBN	denotes	generated
T1775	3672-3676	VBD	denotes	were
T1776	3687-3689	IN	denotes	in
T1777	3690-3703	NN	denotes	collaboration
T1778	3704-3708	IN	denotes	with
T1779	3709-3711	NNP	denotes	Dr
T1780	3720-3727	NNP	denotes	Leviten
T1781	3712-3719	NNP	denotes	Michael
T1782	3728-3729	-LRB-	denotes	(
T1783	3733-3739	NNP	denotes	Carlos
T1784	3729-3732	NNP	denotes	San
T1785	3739-3741	,	denotes	,
T1786	3741-3743	NNP	denotes	CA
T1787	3743-3744	-RRB-	denotes	)
T1788	3744-3745	.	denotes	.
T1789	3745-3894	sentence	denotes	Two genomic clones containing exons 3 to 6 of Mtf1 were used to construct a gene targeting vector for homologous recombination (Supplementary Data).
T1790	3746-3749	CD	denotes	Two
T1791	3758-3764	NNS	denotes	clones
T1792	3750-3757	JJ	denotes	genomic
T1793	3802-3806	VBN	denotes	used
T1794	3765-3775	VBG	denotes	containing
T1795	3776-3781	NNS	denotes	exons
T1796	3782-3783	CD	denotes	3
T1797	3784-3786	IN	denotes	to
T1798	3787-3788	CD	denotes	6
T1799	3789-3791	IN	denotes	of
T1800	3792-3796	NN	denotes	Mtf1
T1801	3797-3801	VBD	denotes	were
T1802	3807-3809	TO	denotes	to
T1803	3810-3819	VB	denotes	construct
T1804	3820-3821	DT	denotes	a
T1805	3837-3843	NN	denotes	vector
T1806	3822-3826	NN	denotes	gene
T1807	3827-3836	NN	denotes	targeting
T1808	3844-3847	IN	denotes	for
T1809	3848-3858	JJ	denotes	homologous
T1810	3859-3872	NN	denotes	recombination
T1811	3873-3874	-LRB-	denotes	(
T1812	3888-3892	NNS	denotes	Data
T1813	3874-3887	JJ	denotes	Supplementary
T1814	3892-3893	-RRB-	denotes	)
T1815	3893-3894	.	denotes	.
T1816	3894-4077	sentence	denotes	A neomycin resistance cassette (PGK-neo) flanked by two loxP sites was cloned into the SacI site 5′ of exon 3 of Mtf1, the third loxP site was cloned into the ScaI site 3′ of exon 4.
T1817	3895-3896	DT	denotes	A
T1818	3917-3925	NN	denotes	cassette
T1819	3897-3905	NN	denotes	neomycin
T1820	3906-3916	NN	denotes	resistance
T1821	3966-3972	VBN	denotes	cloned
T1822	3926-3927	-LRB-	denotes	(
T1823	3927-3930	NN	denotes	PGK
T1824	3931-3934	NN	denotes	neo
T1825	3930-3931	HYPH	denotes	-
T1826	3934-3935	-RRB-	denotes	)
T1827	3936-3943	VBN	denotes	flanked
T1828	3944-3946	IN	denotes	by
T1829	3947-3950	CD	denotes	two
T1830	3956-3961	NNS	denotes	sites
T1831	3951-3955	NN	denotes	loxP
T1832	3962-3965	VBD	denotes	was
T1833	4038-4044	VBN	denotes	cloned
T1834	3973-3977	IN	denotes	into
T1835	3978-3981	DT	denotes	the
T1836	3987-3991	NN	denotes	site
T1837	3982-3986	NN	denotes	SacI
T1838	3992-3993	CD	denotes	5
T1839	3993-3994	SYM	denotes	′
T1840	3995-3997	IN	denotes	of
T1841	3998-4002	NN	denotes	exon
T1842	4003-4004	CD	denotes	3
T1843	4005-4007	IN	denotes	of
T1844	4008-4012	NN	denotes	Mtf1
T1845	4012-4014	,	denotes	,
T1846	4014-4017	DT	denotes	the
T1847	4029-4033	NN	denotes	site
T1848	4018-4023	JJ	denotes	third
T1849	4024-4028	NN	denotes	loxP
T1850	4034-4037	VBD	denotes	was
T1851	4045-4049	IN	denotes	into
T1852	4050-4053	DT	denotes	the
T1853	4059-4063	NN	denotes	site
T1854	4054-4058	NN	denotes	ScaI
T1855	4064-4065	CD	denotes	3
T1856	4065-4066	SYM	denotes	′
T1857	4067-4069	IN	denotes	of
T1858	4070-4074	NN	denotes	exon
T1859	4075-4076	CD	denotes	4
T1860	4076-4077	.	denotes	.
T1861	4077-4154	sentence	denotes	A thymidine kinase (TK) cassette was inserted in the HpaI site 3′ of exon 6.
T1862	4078-4079	DT	denotes	A
T1863	4102-4110	NN	denotes	cassette
T1864	4080-4089	NN	denotes	thymidine
T1865	4090-4096	NN	denotes	kinase
T1866	4097-4098	-LRB-	denotes	(
T1867	4098-4100	NN	denotes	TK
T1868	4100-4101	-RRB-	denotes	)
T1869	4115-4123	VBN	denotes	inserted
T1870	4111-4114	VBD	denotes	was
T1871	4124-4126	IN	denotes	in
T1872	4127-4130	DT	denotes	the
T1873	4136-4140	NN	denotes	site
T1874	4131-4135	NN	denotes	HpaI
T1875	4141-4142	CD	denotes	3
T1876	4142-4143	SYM	denotes	′
T1877	4144-4146	IN	denotes	of
T1878	4147-4151	NN	denotes	exon
T1879	4152-4153	CD	denotes	6
T1880	4153-4154	.	denotes	.
T1881	4154-4347	sentence	denotes	129 ES cells were electroporated with the linearized targeting vector, selected in the presence of G418 and FIAU, and screened for correct integration events by PCR and Southern blot analysis.
T1882	4155-4158	CD	denotes	129
T1883	4162-4167	NNS	denotes	cells
T1884	4159-4161	NN	denotes	ES
T1885	4173-4187	VBN	denotes	electroporated
T1886	4168-4172	VBD	denotes	were
T1887	4188-4192	IN	denotes	with
T1888	4193-4196	DT	denotes	the
T1889	4218-4224	NN	denotes	vector
T1890	4197-4207	VBN	denotes	linearized
T1891	4208-4217	NN	denotes	targeting
T1892	4224-4226	,	denotes	,
T1893	4226-4234	VBN	denotes	selected
T1894	4235-4237	IN	denotes	in
T1895	4238-4241	DT	denotes	the
T1896	4242-4250	NN	denotes	presence
T1897	4251-4253	IN	denotes	of
T1898	4254-4258	NN	denotes	G418
T1899	4259-4262	CC	denotes	and
T1900	4263-4267	NN	denotes	FIAU
T1901	4267-4269	,	denotes	,
T1902	4269-4272	CC	denotes	and
T1903	4273-4281	VBN	denotes	screened
T1904	4282-4285	IN	denotes	for
T1905	4286-4293	JJ	denotes	correct
T1906	4306-4312	NNS	denotes	events
T1907	4294-4305	NN	denotes	integration
T1908	4313-4315	IN	denotes	by
T1909	4316-4319	NN	denotes	PCR
T1910	4338-4346	NN	denotes	analysis
T1911	4320-4323	CC	denotes	and
T1912	4324-4332	NNP	denotes	Southern
T1913	4333-4337	NN	denotes	blot
T1914	4346-4347	.	denotes	.
T1915	4347-4570	sentence	denotes	Transient expression of Cre recombinase led to removal of the PGK-neo cassette, and mice carrying the modified Mtf1loxP allele were generated by injection of positive clones into C57Bl/6 blastocysts and subsequent crosses.
T1916	4348-4357	JJ	denotes	Transient
T1917	4358-4368	NN	denotes	expression
T1918	4388-4391	VBD	denotes	led
T1919	4369-4371	IN	denotes	of
T1920	4372-4375	NN	denotes	Cre
T1921	4376-4387	NN	denotes	recombinase
T1922	4392-4394	IN	denotes	to
T1923	4395-4402	NN	denotes	removal
T1924	4403-4405	IN	denotes	of
T1925	4406-4409	DT	denotes	the
T1926	4418-4426	NN	denotes	cassette
T1927	4410-4413	NN	denotes	PGK
T1928	4414-4417	NN	denotes	neo
T1929	4413-4414	HYPH	denotes	-
T1930	4426-4428	,	denotes	,
T1931	4428-4431	CC	denotes	and
T1932	4432-4436	NNS	denotes	mice
T1933	4480-4489	VBN	denotes	generated
T1934	4437-4445	VBG	denotes	carrying
T1935	4446-4449	DT	denotes	the
T1936	4468-4474	NN	denotes	allele
T1937	4450-4458	VBN	denotes	modified
T1938	4459-4467	NN	denotes	Mtf1loxP
T1939	4475-4479	VBD	denotes	were
T1940	4490-4492	IN	denotes	by
T1941	4493-4502	NN	denotes	injection
T1942	4503-4505	IN	denotes	of
T1943	4506-4514	JJ	denotes	positive
T1944	4515-4521	NNS	denotes	clones
T1945	4522-4526	IN	denotes	into
T1946	4527-4532	NN	denotes	C57Bl
T1947	4535-4546	NNS	denotes	blastocysts
T1948	4532-4533	HYPH	denotes	/
T1949	4533-4534	CD	denotes	6
T1950	4547-4550	CC	denotes	and
T1951	4551-4561	JJ	denotes	subsequent
T1952	4562-4569	NNS	denotes	crosses
T1953	4569-4570	.	denotes	.
T1955	4571-4581	JJ	denotes	Homozygous
T1956	4603-4610	NNS	denotes	animals
T1957	4582-4593	JJ	denotes	conditional
T1958	4594-4602	NN	denotes	knockout
T1959	4632-4639	VBN	denotes	crossed
T1960	4611-4612	-LRB-	denotes	(
T1961	4612-4620	NN	denotes	Mtf1loxP
T1962	4621-4625	NN	denotes	loxP
T1963	4620-4621	HYPH	denotes	/
T1964	4625-4626	-RRB-	denotes	)
T1965	4627-4631	VBD	denotes	were
T1966	4640-4644	IN	denotes	with
T1967	4645-4648	DT	denotes	the
T1968	4676-4680	NN	denotes	line
T2099	4778-4779	.	denotes	.
T2100	4779-5033	sentence	denotes	The mice were genotyped by PCR using the following primers (Microsynth): Cre recombinase: 5′-CTATCCAGCAACATTTGGGCCAGC-3′; 5′-CCAGGTTACGGATATAGTTCATGAC-3′, Mtf1loxP or wild-type allele: 5′-CACACCCAGTTTGTGTATGTCTTC-3′; 5′-CAGTCACAAGCAAATTACCAAACACTGCC-3′.
T2101	4780-4783	DT	denotes	The
T2102	4784-4788	NNS	denotes	mice
T2103	4794-4803	VBN	denotes	genotyped
T2104	4789-4793	VBD	denotes	were
T2105	4804-4806	IN	denotes	by
T2106	4807-4810	NN	denotes	PCR
T2107	4811-4816	VBG	denotes	using
T2108	4817-4820	DT	denotes	the
T2109	4831-4838	NNS	denotes	primers
T2110	4821-4830	VBG	denotes	following
T2111	4839-4840	-LRB-	denotes	(
T2112	4840-4850	NNP	denotes	Microsynth
T2113	4850-4851	-RRB-	denotes	)
T2114	4851-4853	:	denotes	:
T2115	4853-4856	NN	denotes	Cre
T2116	4857-4868	NN	denotes	recombinase
T2117	4905-4930	NN	denotes	CCAGGTTACGGATATAGTTCATGAC
T2118	4868-4870	:	denotes	:
T2119	4870-4871	CD	denotes	5
T2120	4873-4897	NN	denotes	CTATCCAGCAACATTTGGGCCAGC
T2121	4871-4872	SYM	denotes	′
T2122	4872-4873	HYPH	denotes	-
T2123	4897-4898	HYPH	denotes	-
T2124	4898-4899	CD	denotes	3
T2125	4899-4900	SYM	denotes	′
T2126	4900-4901	:	denotes	;
T2127	4902-4903	CD	denotes	5
T2128	4903-4904	SYM	denotes	′
T2129	4904-4905	HYPH	denotes	-
T2130	5000-5029	NN	denotes	CAGTCACAAGCAAATTACCAAACACTGCC
T2131	4930-4931	HYPH	denotes	-
T2132	4931-4932	CD	denotes	3
T2133	4932-4933	SYM	denotes	′
T2134	4933-4935	,	denotes	,
T2135	4935-4943	NN	denotes	Mtf1loxP
T2136	4944-4946	CC	denotes	or
T2137	4947-4951	JJ	denotes	wild
T2138	4952-4956	NN	denotes	type
T2139	4951-4952	HYPH	denotes	-
T2140	4957-4963	NN	denotes	allele
T2141	4963-4965	:	denotes	:
T2142	4965-4966	CD	denotes	5
T2143	4968-4992	NN	denotes	CACACCCAGTTTGTGTATGTCTTC
T2144	4966-4967	SYM	denotes	′
T2145	4967-4968	HYPH	denotes	-
T2146	4992-4993	HYPH	denotes	-
T2147	4993-4994	CD	denotes	3
T2148	4994-4995	SYM	denotes	′
T2149	4995-4996	:	denotes	;
T2150	4997-4998	CD	denotes	5
T2151	4998-4999	SYM	denotes	′
T2152	4999-5000	HYPH	denotes	-
T2153	5029-5030	HYPH	denotes	-
T2154	5030-5031	CD	denotes	3
T2155	5031-5032	SYM	denotes	′
T2156	5032-5033	.	denotes	.
T2531	5866-5876	NN	denotes	Microarray
T2532	5877-5885	NN	denotes	analysis
T2533	5886-5889	CC	denotes	and
T2534	5890-5894	NNS	denotes	data
T2535	5895-5905	NN	denotes	processing
T2536	5905-6131	sentence	denotes	Total RNA was isolated from liver tissue of pI–pC-induced, mock- or cadmium-treated Mtf1Mx-cre and Mtf1loxP mice (n = 3 per genotype and respective treatment; all male) essentially as described by Chomczynski and Sacchi (27).
T2537	5906-5911	JJ	denotes	Total
T2538	5912-5915	NN	denotes	RNA
T2539	5920-5928	VBN	denotes	isolated
T2540	5916-5919	VBD	denotes	was
T2541	5929-5933	IN	denotes	from
T2542	5934-5939	NN	denotes	liver
T2543	5940-5946	NN	denotes	tissue
T2544	5947-5949	IN	denotes	of
T2545	5950-5952	NN	denotes	pI
T2546	5953-5955	NN	denotes	pC
T2547	5952-5953	HYPH	denotes	–
T2548	5956-5963	VBN	denotes	induced
T2549	5955-5956	HYPH	denotes	-
T2550	6014-6018	NNS	denotes	mice
T2551	5963-5965	,	denotes	,
T2552	5965-5969	JJ	denotes	mock
T2553	5982-5989	VBN	denotes	treated
T2554	5969-5970	HYPH	denotes	-
T2555	5971-5973	CC	denotes	or
T2556	5974-5981	NN	denotes	cadmium
T2557	5981-5982	HYPH	denotes	-
T2558	5990-5996	NN	denotes	Mtf1Mx
T2559	5997-6000	NN	denotes	cre
T2560	5996-5997	HYPH	denotes	-
T2561	6001-6004	CC	denotes	and
T2562	6005-6013	NN	denotes	Mtf1loxP
T2563	6019-6020	-LRB-	denotes	(
T2564	6069-6073	JJ	denotes	male
T2565	6020-6021	NN	denotes	n
T2566	6024-6025	CD	denotes	3
T2567	6022-6023	SYM	denotes	=
T2568	6026-6029	IN	denotes	per
T2569	6030-6038	NN	denotes	genotype
T2570	6039-6042	CC	denotes	and
T2571	6043-6053	JJ	denotes	respective
T2572	6054-6063	NN	denotes	treatment
T2573	6063-6064	:	denotes	;
T2574	6065-6068	DT	denotes	all
T2575	6073-6074	-RRB-	denotes	)
T2576	6075-6086	RB	denotes	essentially
T2577	6090-6099	VBN	denotes	described
T2578	6087-6089	IN	denotes	as
T2579	6100-6102	IN	denotes	by
T2580	6103-6114	NNP	denotes	Chomczynski
T2581	6115-6118	CC	denotes	and
T2582	6119-6125	NNP	denotes	Sacchi
T2583	6126-6127	-LRB-	denotes	(
T2584	6127-6129	CD	denotes	27
T2585	6129-6130	-RRB-	denotes	)
T2586	6130-6131	.	denotes	.
T2587	6131-6356	sentence	denotes	Gene expression analysis was performed in the Functional Genomics Center Zurich using GeneChip® Mouse Genome 430 2.0 Arrays (Affymetrix) according to the manufacturer's instructions and the following reagents and conditions.
T2588	6132-6136	NN	denotes	Gene
T2589	6137-6147	NN	denotes	expression
T2590	6148-6156	NN	denotes	analysis
T2591	6161-6170	VBN	denotes	performed
T2592	6157-6160	VBD	denotes	was
T2593	6171-6173	IN	denotes	in
T2594	6174-6177	DT	denotes	the
T2595	6198-6204	NNP	denotes	Center
T2596	6178-6188	NNP	denotes	Functional
T2597	6189-6197	NNP	denotes	Genomics
T2598	6205-6211	NNP	denotes	Zurich
T2599	6212-6217	VBG	denotes	using
T2600	6218-6227	NNP	denotes	GeneChip®
T2601	6249-6255	NNS	denotes	Arrays
T2602	6228-6233	NNP	denotes	Mouse
T2603	6234-6240	NNP	denotes	Genome
T2604	6241-6244	CD	denotes	430
T2605	6245-6248	CD	denotes	2.0
T2606	6256-6257	-LRB-	denotes	(
T2607	6257-6267	NNP	denotes	Affymetrix
T2608	6267-6268	-RRB-	denotes	)
T2609	6269-6278	VBG	denotes	according
T2610	6279-6281	IN	denotes	to
T2611	6282-6285	DT	denotes	the
T2612	6286-6298	NN	denotes	manufacturer
T2613	6301-6313	NNS	denotes	instructions
T2614	6298-6300	POS	denotes	's
T2615	6314-6317	CC	denotes	and
T2616	6318-6321	DT	denotes	the
T2617	6332-6340	NNS	denotes	reagents
T2618	6322-6331	VBG	denotes	following
T2619	6341-6344	CC	denotes	and
T2620	6345-6355	NNS	denotes	conditions
T2621	6355-6356	.	denotes	.
T2622	6356-6467	sentence	denotes	cDNA was synthesized with SuperScript™ Double-Stranded cDNA Synthesis Kit (Invitrogen), using 15 µg total RNA.
T2623	6357-6361	NN	denotes	cDNA
T2624	6366-6377	VBN	denotes	synthesized
T2625	6362-6365	VBD	denotes	was
T2626	6378-6382	IN	denotes	with
T2627	6383-6394	NNP	denotes	SuperScript
T2628	6427-6430	NN	denotes	Kit
T2629	6394-6395	SYM	denotes	™
T2630	6396-6402	JJ	denotes	Double
T2631	6403-6411	VBN	denotes	Stranded
T2632	6402-6403	HYPH	denotes	-
T2633	6412-6416	NN	denotes	cDNA
T2634	6417-6426	NN	denotes	Synthesis
T2635	6431-6432	-LRB-	denotes	(
T2636	6432-6442	NNP	denotes	Invitrogen
T2637	6442-6443	-RRB-	denotes	)
T2638	6443-6445	,	denotes	,
T2639	6445-6450	VBG	denotes	using
T2640	6451-6453	CD	denotes	15
T2641	6454-6456	NN	denotes	µg
T2642	6463-6466	NN	denotes	RNA
T2643	6457-6462	JJ	denotes	total
T2644	6466-6467	.	denotes	.
T2645	6467-6596	sentence	denotes	In vitro transcription was performed with BioArray™ High Yield™ RNA Transcript Labeling Kit (Enzo) and 3.5 to 6 µg of each cDNA.
T2646	6468-6470	FW	denotes	In
T2647	6471-6476	FW	denotes	vitro
T2648	6477-6490	NN	denotes	transcription
T2649	6495-6504	VBN	denotes	performed
T2650	6491-6494	VBD	denotes	was
T2651	6505-6509	IN	denotes	with
T2652	6510-6518	NNP	denotes	BioArray
T2653	6556-6559	NN	denotes	Kit
T2654	6518-6519	SYM	denotes	™
T2655	6520-6524	NNP	denotes	High
T2656	6525-6530	NNP	denotes	Yield
T2657	6530-6531	SYM	denotes	™
T2658	6532-6535	NN	denotes	RNA
T2659	6536-6546	NN	denotes	Transcript
T2660	6547-6555	NN	denotes	Labeling
T2661	6560-6561	-LRB-	denotes	(
T2662	6561-6565	NNP	denotes	Enzo
T2663	6565-6566	-RRB-	denotes	)
T2664	6567-6570	CC	denotes	and
T2665	6571-6574	CD	denotes	3.5
T2666	6578-6579	CD	denotes	6
T2667	6575-6577	IN	denotes	to
T2668	6580-6582	NN	denotes	µg
T2669	6583-6585	IN	denotes	of
T2670	6586-6590	DT	denotes	each
T2671	6591-6595	NN	denotes	cDNA
T2672	6595-6596	.	denotes	.
T2673	6596-6697	sentence	denotes	Clean-up of both cDNA and cRNA samples was done using GeneChip® Sample Clean-up Module (Affymetrix).
T2674	6597-6602	NN	denotes	Clean
T2675	6603-6605	NN	denotes	up
T2676	6602-6603	HYPH	denotes	-
T2677	6640-6644	VBN	denotes	done
T2678	6606-6608	IN	denotes	of
T2679	6609-6613	CC	denotes	both
T2680	6614-6618	NN	denotes	cDNA
T2681	6628-6635	NNS	denotes	samples
T2682	6619-6622	CC	denotes	and
T2683	6623-6627	NN	denotes	cRNA
T2684	6636-6639	VBD	denotes	was
T2685	6645-6650	VBG	denotes	using
T2686	6651-6660	NNP	denotes	GeneChip®
T2687	6677-6683	NNP	denotes	Module
T2688	6661-6667	NNP	denotes	Sample
T2689	6668-6673	NNP	denotes	Clean
T2690	6674-6676	NNP	denotes	up
T2691	6673-6674	HYPH	denotes	-
T2692	6684-6685	-LRB-	denotes	(
T2693	6685-6695	NNP	denotes	Affymetrix
T2694	6695-6696	-RRB-	denotes	)
T2695	6696-6697	.	denotes	.
T2696	6697-6815	sentence	denotes	For the automated washing and staining in the Affymetrix fluidics station 450, the protocol EukGE-Ws2v4_450 was used.
T2697	6698-6701	IN	denotes	For
T2698	6810-6814	VBN	denotes	used
T2699	6702-6705	DT	denotes	the
T2700	6716-6723	NN	denotes	washing
T2701	6706-6715	VBN	denotes	automated
T2702	6724-6727	CC	denotes	and
T2703	6728-6736	NN	denotes	staining
T2704	6737-6739	IN	denotes	in
T2705	6740-6743	DT	denotes	the
T2706	6764-6771	NN	denotes	station
T2707	6744-6754	NNP	denotes	Affymetrix
T2708	6755-6763	NN	denotes	fluidics
T2709	6772-6775	CD	denotes	450
T2710	6775-6777	,	denotes	,
T2711	6777-6780	DT	denotes	the
T2712	6796-6805	NN	denotes	Ws2v4_450
T2713	6781-6789	NN	denotes	protocol
T2714	6790-6795	NN	denotes	EukGE
T2715	6795-6796	HYPH	denotes	-
T2716	6806-6809	VBD	denotes	was
T2717	6814-6815	.	denotes	.
T2718	6815-6882	sentence	denotes	The probe arrays were scanned with the Affymetrix GS 3000 scanner.
T2719	6816-6819	DT	denotes	The
T2720	6826-6832	NNS	denotes	arrays
T2721	6820-6825	NN	denotes	probe
T2722	6838-6845	VBN	denotes	scanned
T2723	6833-6837	VBD	denotes	were
T2724	6846-6850	IN	denotes	with
T2725	6851-6854	DT	denotes	the
T2726	6874-6881	NN	denotes	scanner
T2727	6855-6865	NNP	denotes	Affymetrix
T2728	6866-6868	NNP	denotes	GS
T2729	6869-6873	CD	denotes	3000
T2730	6881-6882	.	denotes	.
T2731	6882-6954	sentence	denotes	Raw data are available at ArrayExpress (, accession number E-MEXP-438).
T2732	6883-6886	JJ	denotes	Raw
T2733	6887-6891	NNS	denotes	data
T2734	6892-6895	VBP	denotes	are
T2735	6896-6905	JJ	denotes	available
T2736	6906-6908	IN	denotes	at
T2737	6909-6921	NNP	denotes	ArrayExpress
T2738	6922-6923	-LRB-	denotes	(
T2739	6944-6948	NN	denotes	MEXP
T2740	6923-6925	,	denotes	,
T2741	6925-6934	NN	denotes	accession
T2742	6935-6941	NN	denotes	number
T2743	6942-6943	NN	denotes	E
T2744	6943-6944	HYPH	denotes	-
T2745	6948-6949	HYPH	denotes	-
T2746	6949-6952	CD	denotes	438
T2747	6952-6953	-RRB-	denotes	)
T2748	6953-6954	.	denotes	.
T2749	6954-7071	sentence	denotes	Data analysis was performed with GeneSpring 6.1 software (Silicon Genetics), applying a significance level P ≤ 0.05.
T2750	6955-6959	NNS	denotes	Data
T2751	6960-6968	NN	denotes	analysis
T2752	6973-6982	VBN	denotes	performed
T2753	6969-6972	VBD	denotes	was
T2754	6983-6987	IN	denotes	with
T2755	6988-6998	NNP	denotes	GeneSpring
T2756	7003-7011	NN	denotes	software
T2757	6999-7002	CD	denotes	6.1
T2758	7012-7013	-LRB-	denotes	(
T2759	7021-7029	NNP	denotes	Genetics
T2760	7013-7020	NNP	denotes	Silicon
T2761	7029-7030	-RRB-	denotes	)
T2762	7030-7032	,	denotes	,
T2763	7032-7040	VBG	denotes	applying
T2764	7041-7042	DT	denotes	a
T2765	7056-7061	NN	denotes	level
T2766	7043-7055	NN	denotes	significance
T2767	7062-7063	NN	denotes	P
T2768	7066-7070	CD	denotes	0.05
T2769	7064-7065	SYM	denotes	≤
T2770	7070-7071	.	denotes	.
T2771	7071-7188	sentence	denotes	Furthermore, multiple testing correction was used in addition to obtain cadmium-responsive, MTF-1-independent genes.
T2772	7072-7083	RB	denotes	Furthermore
T2773	7117-7121	VBN	denotes	used
T2774	7083-7085	,	denotes	,
T2775	7085-7093	JJ	denotes	multiple
T2776	7102-7112	NN	denotes	correction
T2777	7094-7101	NN	denotes	testing
T2778	7113-7116	VBD	denotes	was
T2779	7122-7124	IN	denotes	in
T2780	7125-7133	NN	denotes	addition
T2781	7134-7136	TO	denotes	to
T2782	7137-7143	VB	denotes	obtain
T2783	7144-7151	NN	denotes	cadmium
T2784	7152-7162	JJ	denotes	responsive
T2785	7151-7152	HYPH	denotes	-
T2786	7182-7187	NNS	denotes	genes
T2787	7162-7164	,	denotes	,
T2788	7164-7167	NN	denotes	MTF
T2789	7170-7181	JJ	denotes	independent
T2790	7167-7168	HYPH	denotes	-
T2791	7168-7169	CD	denotes	1
T2792	7169-7170	HYPH	denotes	-
T2793	7187-7188	.	denotes	.
T2794	7188-7377	sentence	denotes	Genes were considered to be differentially expressed if there was at least a 2-fold difference in expression levels of the compared experimental groups (genotype and respective treatment).
T2795	7189-7194	NNS	denotes	Genes
T2796	7200-7210	VBN	denotes	considered
T2797	7195-7199	VBD	denotes	were
T2798	7211-7213	TO	denotes	to
T2799	7232-7241	VBN	denotes	expressed
T2800	7214-7216	VB	denotes	be
T2801	7217-7231	RB	denotes	differentially
T2802	7242-7244	IN	denotes	if
T2803	7251-7254	VBD	denotes	was
T2804	7245-7250	EX	denotes	there
T2805	7255-7257	RB	denotes	at
T2806	7258-7263	RBS	denotes	least
T2807	7266-7272	JJ	denotes	2-fold
T2808	7264-7265	DT	denotes	a
T2809	7273-7283	NN	denotes	difference
T2810	7284-7286	IN	denotes	in
T2811	7287-7297	NN	denotes	expression
T2812	7298-7304	NNS	denotes	levels
T2813	7305-7307	IN	denotes	of
T2814	7308-7311	DT	denotes	the
T2815	7334-7340	NNS	denotes	groups
T2816	7312-7320	VBN	denotes	compared
T2817	7321-7333	JJ	denotes	experimental
T2818	7341-7342	-LRB-	denotes	(
T2819	7342-7350	NN	denotes	genotype
T2820	7351-7354	CC	denotes	and
T2821	7355-7365	JJ	denotes	respective
T2822	7366-7375	NN	denotes	treatment
T2823	7375-7376	-RRB-	denotes	)
T2824	7376-7377	.	denotes	.
T2825	7377-7562	sentence	denotes	The result was considered reliable if signal values for the respective gene were scored ‘present’ at least for all mice in one experimental group or for two mice in each of two groups.
T2826	7378-7381	DT	denotes	The
T2827	7382-7388	NN	denotes	result
T2828	7393-7403	VBN	denotes	considered
T2829	7389-7392	VBD	denotes	was
T2830	7404-7412	JJ	denotes	reliable
T2831	7413-7415	IN	denotes	if
T2832	7459-7465	VBN	denotes	scored
T2833	7416-7422	NN	denotes	signal
T2834	7423-7429	NNS	denotes	values
T2835	7430-7433	IN	denotes	for
T2836	7434-7437	DT	denotes	the
T2837	7449-7453	NN	denotes	gene
T2838	7438-7448	JJ	denotes	respective
T2839	7454-7458	VBD	denotes	were
T2840	7466-7467	``	denotes	‘
T2841	7467-7474	JJ	denotes	present
T2842	7474-7475	''	denotes	’
T2843	7476-7478	RB	denotes	at
T2844	7479-7484	RBS	denotes	least
T2845	7485-7488	IN	denotes	for
T2846	7489-7492	DT	denotes	all
T2847	7493-7497	NNS	denotes	mice
T2848	7498-7500	IN	denotes	in
T2849	7501-7504	CD	denotes	one
T2850	7518-7523	NN	denotes	group
T2851	7505-7517	JJ	denotes	experimental
T2852	7524-7526	CC	denotes	or
T2853	7527-7530	IN	denotes	for
T2854	7531-7534	CD	denotes	two
T2855	7535-7539	NNS	denotes	mice
T2856	7540-7542	IN	denotes	in
T2857	7543-7547	DT	denotes	each
T2858	7548-7550	IN	denotes	of
T2859	7551-7554	CD	denotes	two
T2860	7555-7561	NNS	denotes	groups
T2861	7561-7562	.	denotes	.
T2862	7562-7825	sentence	denotes	To screen for the presence of the MRE core consensus sequence TGCRCNC in the promoter region, the upstream sequences of the respective genes were obtained from the University of California Santa Cruz (UCSC) Genome Browser Database (; October/November 2004) (28).
T2863	7563-7565	TO	denotes	To
T2864	7566-7572	VB	denotes	screen
T2865	7709-7717	VBN	denotes	obtained
T2866	7573-7576	IN	denotes	for
T2867	7577-7580	DT	denotes	the
T2868	7581-7589	NN	denotes	presence
T2869	7590-7592	IN	denotes	of
T2870	7593-7596	DT	denotes	the
T2871	7616-7624	NN	denotes	sequence
T2872	7597-7600	NN	denotes	MRE
T2873	7601-7605	NN	denotes	core
T2874	7606-7615	NN	denotes	consensus
T2875	7625-7632	NN	denotes	TGCRCNC
T2876	7633-7635	IN	denotes	in
T2877	7636-7639	DT	denotes	the
T2878	7649-7655	NN	denotes	region
T2879	7640-7648	NN	denotes	promoter
T2880	7655-7657	,	denotes	,
T2881	7657-7660	DT	denotes	the
T2882	7670-7679	NNS	denotes	sequences
T2883	7661-7669	JJ	denotes	upstream
T2884	7680-7682	IN	denotes	of
T2885	7683-7686	DT	denotes	the
T2886	7698-7703	NNS	denotes	genes
T2887	7687-7697	JJ	denotes	respective
T2888	7704-7708	VBD	denotes	were
T2889	7718-7722	IN	denotes	from
T2890	7723-7726	DT	denotes	the
T2891	7785-7793	NNP	denotes	Database
T2892	7727-7737	NNP	denotes	University
T2893	7738-7740	IN	denotes	of
T2894	7741-7751	NNP	denotes	California
T2895	7758-7762	NNP	denotes	Cruz
T2896	7752-7757	NNP	denotes	Santa
T2897	7763-7764	-LRB-	denotes	(
T2898	7764-7768	NNP	denotes	UCSC
T2899	7768-7769	-RRB-	denotes	)
T2900	7770-7776	NNP	denotes	Genome
T2901	7777-7784	NNP	denotes	Browser
T2902	7794-7795	-LRB-	denotes	(
T2903	7805-7813	NNP	denotes	November
T2904	7795-7796	:	denotes	;
T2905	7797-7804	NNP	denotes	October
T2906	7804-7805	SYM	denotes	/
T2907	7814-7818	CD	denotes	2004
T2908	7818-7819	-RRB-	denotes	)
T2909	7820-7821	-LRB-	denotes	(
T2910	7821-7823	CD	denotes	28
T2911	7823-7824	-RRB-	denotes	)
T2912	7824-7825	.	denotes	.
T3025	8241-8242	SYM	denotes	′
T3026	8242-8243	HYPH	denotes	-
T3351	9059-9074	JJ	denotes	Electrophoretic
T3352	9084-9089	NN	denotes	shift
T3353	9075-9083	NN	denotes	mobility
T3354	9090-9095	NN	denotes	assay
T3355	9096-9097	-LRB-	denotes	(
T3356	9097-9101	NN	denotes	EMSA
T3357	9101-9102	-RRB-	denotes	)
T3358	9102-9306	sentence	denotes	Protein was extracted from liver tissue with T-PER™ Tissue Protein Extraction Reagent (Pierce) according to the manufacturer's instructions, using a 1:10 ratio of mouse tissue (mg) to T-PER reagent (µl).
T3359	9103-9110	NN	denotes	Protein
T3360	9115-9124	VBN	denotes	extracted
T3361	9111-9114	VBD	denotes	was
T3362	9125-9129	IN	denotes	from
T3363	9130-9135	NN	denotes	liver
T3364	9136-9142	NN	denotes	tissue
T3365	9143-9147	IN	denotes	with
T3366	9148-9149	NN	denotes	T
T3367	9150-9153	NN	denotes	PER
T3368	9149-9150	HYPH	denotes	-
T3369	9153-9154	SYM	denotes	™
T3370	9155-9161	NN	denotes	Tissue
T3371	9162-9169	NN	denotes	Protein
T3372	9170-9180	NN	denotes	Extraction
T3373	9181-9188	NN	denotes	Reagent
T3374	9189-9190	-LRB-	denotes	(
T3375	9190-9196	NNP	denotes	Pierce
T3376	9196-9197	-RRB-	denotes	)
T3377	9198-9207	VBG	denotes	according
T3378	9208-9210	IN	denotes	to
T3379	9211-9214	DT	denotes	the
T3380	9215-9227	NN	denotes	manufacturer
T3381	9230-9242	NNS	denotes	instructions
T3382	9227-9229	POS	denotes	's
T3383	9242-9244	,	denotes	,
T3384	9244-9249	VBG	denotes	using
T3385	9250-9251	DT	denotes	a
T3386	9257-9262	NN	denotes	ratio
T3387	9252-9253	CD	denotes	1
T3388	9253-9254	SYM	denotes	:
T3389	9254-9256	CD	denotes	10
T3390	9263-9265	IN	denotes	of
T3391	9266-9271	NN	denotes	mouse
T3392	9272-9278	NN	denotes	tissue
T3393	9279-9280	-LRB-	denotes	(
T3394	9280-9282	NN	denotes	mg
T3395	9282-9283	-RRB-	denotes	)
T3396	9284-9286	IN	denotes	to
T3397	9287-9288	NN	denotes	T
T3398	9289-9292	NN	denotes	PER
T3399	9288-9289	HYPH	denotes	-
T3400	9293-9300	NN	denotes	reagent
T3401	9301-9302	-LRB-	denotes	(
T3402	9302-9304	NN	denotes	µl
T3403	9304-9305	-RRB-	denotes	)
T3404	9305-9306	.	denotes	.
T3405	9306-9367	sentence	denotes	EMSA was essentially performed as previously described (10).
T3406	9307-9311	NN	denotes	EMSA
T3407	9328-9337	VBN	denotes	performed
T3408	9312-9315	VBD	denotes	was
T3409	9316-9327	RB	denotes	essentially
T3410	9338-9340	IN	denotes	as
T3411	9352-9361	VBN	denotes	described
T3412	9341-9351	RB	denotes	previously
T3413	9362-9363	-LRB-	denotes	(
T3414	9363-9365	CD	denotes	10
T3415	9365-9366	-RRB-	denotes	)
T3416	9366-9367	.	denotes	.
T3417	9367-9520	sentence	denotes	All binding reactions were carried out by incubating 2–5 fmol 32P-end-labeled double-stranded oligonucleotides with 100 to 130 µg liver protein extract.
T3418	9368-9371	DT	denotes	All
T3419	9380-9389	NNS	denotes	reactions
T3420	9372-9379	NN	denotes	binding
T3421	9395-9402	VBN	denotes	carried
T3422	9390-9394	VBD	denotes	were
T3423	9403-9406	RP	denotes	out
T3424	9407-9409	IN	denotes	by
T3425	9410-9420	VBG	denotes	incubating
T3426	9421-9422	CD	denotes	2
T3427	9423-9424	CD	denotes	5
T3428	9422-9423	SYM	denotes	–
T3429	9425-9429	NN	denotes	fmol
T3430	9462-9478	NNS	denotes	oligonucleotides
T3431	9430-9433	NN	denotes	32P
T3432	9438-9445	VBN	denotes	labeled
T3433	9433-9434	HYPH	denotes	-
T3434	9434-9437	NN	denotes	end
T3435	9437-9438	HYPH	denotes	-
T3436	9446-9452	JJ	denotes	double
T3437	9453-9461	VBN	denotes	stranded
T3438	9452-9453	HYPH	denotes	-
T3439	9479-9483	IN	denotes	with
T3440	9484-9487	CD	denotes	100
T3441	9491-9494	CD	denotes	130
T3442	9488-9490	IN	denotes	to
T3443	9495-9497	NN	denotes	µg
T3444	9512-9519	NN	denotes	extract
T3445	9498-9503	NN	denotes	liver
T3446	9504-9511	NN	denotes	protein
T3447	9519-9520	.	denotes	.
T3448	9520-9662	sentence	denotes	For competition experiments, 5 pmol of unlabeled competitor oligonucleotide was added to the binding reaction before addition of the extract.
T3449	9521-9524	IN	denotes	For
T3450	9601-9606	VBN	denotes	added
T3451	9525-9536	NN	denotes	competition
T3452	9537-9548	NNS	denotes	experiments
T3453	9548-9550	,	denotes	,
T3454	9550-9551	CD	denotes	5
T3455	9552-9556	NN	denotes	pmol
T3456	9557-9559	IN	denotes	of
T3457	9560-9569	JJ	denotes	unlabeled
T3458	9581-9596	NN	denotes	oligonucleotide
T3459	9570-9580	NN	denotes	competitor
T3460	9597-9600	VBD	denotes	was
T3461	9607-9609	IN	denotes	to
T3462	9610-9613	DT	denotes	the
T3463	9622-9630	NN	denotes	reaction
T3464	9614-9621	NN	denotes	binding
T3465	9631-9637	IN	denotes	before
T3466	9638-9646	NN	denotes	addition
T3467	9647-9649	IN	denotes	of
T3468	9650-9653	DT	denotes	the
T3469	9654-9661	NN	denotes	extract
T3470	9661-9662	.	denotes	.
T3471	9662-9734	sentence	denotes	All EMSA gels were developed using PhosphorImager (Molecular Dynamics).
T3472	9663-9666	DT	denotes	All
T3473	9672-9676	NNS	denotes	gels
T3474	9667-9671	NN	denotes	EMSA
T3475	9682-9691	VBN	denotes	developed
T3476	9677-9681	VBD	denotes	were
T3477	9692-9697	VBG	denotes	using
T3478	9698-9712	NNP	denotes	PhosphorImager
T3479	9713-9714	-LRB-	denotes	(
T3480	9724-9732	NNP	denotes	Dynamics
T3481	9714-9723	NNP	denotes	Molecular
T3482	9732-9733	-RRB-	denotes	)
T3483	9733-9734	.	denotes	.
T3484	9734-11196	sentence	denotes	The following oligonucleotides were annealed and used for the reactions: Csrp1 MRE1: 5′-GGAAACAAAACGGCGCGCACTCCGGCGC-3′; 5′-GGCTGCGC CGGAGTGCGCGCCGTTTTGT-3′, Csrp1 MRE2: 5′-TGTTGTGGTGCAGTGTGCAAAGCCTAC-3′; 5′-ACCAGTAGGCTTTGCACACTGCACCAC-3′, Csrp1 MRE3: 5′-GAGATCGCCATAGGGTGCAAAGAGAAG-3′; 5′-GTGACTTCTCTTTGCACCCTATGGCGA-3′, Csrp1 MRE4: 5′-TGTCTTATTCTGGAGTGCAAGTTAGTC-3′; 5′-AGGGGACTAACTTGCACTCCAGAATAA-3′, Gal4: 5′-TCCGGAGGACTGTCCTCCGG-3′; 5′-GCCGGAGGACAGTCCTCCGG-3′, MREd [MRE derived from mouse Mt1 promoter (10)]: 5′-CGAGGGAGCTCTGCACTCCGCCCGAAAAGTG-3′; 5′-TCGACACTTTTCGGGCGGAGTGCAGAGCTCCCTCGAGCT-3′, MRE-s [synthetic MRE consensus sequence (10)]: 5′-CGAGGGAGCTCTGCACACGGCCCGAAAAGTG-3′; 5′-TCGACACTTTTCGGGCCGTGTGCAGAGCTCCCTCGAGCT-3′, Ndrg1 MRE1: 5′-CAGCCCAGGCAGGGTGCAGCACGAG-3′; 5′-CCGCCTCGTGCTGCACCCTGCCTGG-3′, Ndrg1 MRE2: 5′-CACACGTTCGCTGCACACGCCGCGG-3′; 5′-GGGACCGCGGCGTGTGCAGCGAACG-3′, Ndrg1 MRE3,4: 5′-GGAGTCCTTATGCACACGCGCACGAGCGCGCACGGGCAC-3′; 5′-TGGTGTGCCCGTGCGCGCTCGTGCGCGTGTGCATAAGGAC-3′, Sepw1 MRE1: 5′-GAGGCAGTCGGCTGTGCGCACGGCCCCACGCTC-3′; 5′-CTCTGAGCGTGGGGCCGTGCGCACAGCCGACTGC-3′, Sepw1 MRE2: 5′-ATGGTTTTGGGGGTGCGCAGGGGGTCTG-3′; 5′-CGACAGACCCCCTGCGCACCCCCAAAAC-3′, Slc39a10 MRE1: 5′-GAATACACGACTGGGTGCAGCCGGGGTTTGG-3′; 5′-GGTACCAAACCCCGGCTGCACCCAGTCGTGTA-3′, Slc39a10 MRE2: 5′-GCGGAGAGGAGATGCACACGGCACTCG-3′; 5′-CACTCGAGTGCCGTGTGCATCTCCTCT-3′, Specificity protein 1 (Sp1) binding sequence (10): 5′-CGAGGCCCCGCCCAG-3′; 5′-TCGACTGGGCGGGGCCTCGAGct-3′.
T3485	9735-9738	DT	denotes	The
T3486	9749-9765	NNS	denotes	oligonucleotides
T3487	9739-9748	VBG	denotes	following
T3488	9771-9779	VBN	denotes	annealed
T3489	9766-9770	VBD	denotes	were
T3490	9780-9783	CC	denotes	and
T3491	9784-9788	VBN	denotes	used
T3492	9789-9792	IN	denotes	for
T3493	9793-9796	DT	denotes	the
T3494	9797-9806	NNS	denotes	reactions
T3495	9806-9808	:	denotes	:
T3496	9808-9813	NN	denotes	Csrp1
T3497	9814-9818	NN	denotes	MRE1
T3498	9818-9820	:	denotes	:
T3499	9820-9821	CD	denotes	5
T3500	9823-9851	NN	denotes	GGAAACAAAACGGCGCGCACTCCGGCGC
T3501	9821-9822	SYM	denotes	′
T3502	9822-9823	HYPH	denotes	-
T3503	9851-9852	HYPH	denotes	-
T3504	9852-9853	CD	denotes	3
T3505	9853-9854	SYM	denotes	′
T3506	9854-9855	:	denotes	;
T3507	9856-9857	CD	denotes	5
T3508	9868-9888	NN	denotes	CGGAGTGCGCGCCGTTTTGT
T3509	9857-9858	SYM	denotes	′
T3510	9858-9859	HYPH	denotes	-
T3511	9859-9867	NN	denotes	GGCTGCGC
T3512	9888-9889	HYPH	denotes	-
T3513	9889-9890	CD	denotes	3
T3514	9890-9891	SYM	denotes	′
T3515	9891-9893	,	denotes	,
T3516	9893-9898	NN	denotes	Csrp1
T3517	9899-9903	NN	denotes	MRE2
T3518	9903-9905	:	denotes	:
T3519	9905-9906	CD	denotes	5
T3520	9908-9935	NN	denotes	TGTTGTGGTGCAGTGTGCAAAGCCTAC
T3521	9906-9907	SYM	denotes	′
T3522	9907-9908	HYPH	denotes	-
T3523	9935-9936	HYPH	denotes	-
T3524	9936-9937	CD	denotes	3
T3525	9937-9938	SYM	denotes	′
T3526	9938-9939	:	denotes	;
T3527	9940-9941	CD	denotes	5
T3528	9943-9970	NN	denotes	ACCAGTAGGCTTTGCACACTGCACCAC
T3529	9941-9942	SYM	denotes	′
T3530	9942-9943	HYPH	denotes	-
T3531	9970-9971	HYPH	denotes	-
T3532	9971-9972	CD	denotes	3
T3533	9972-9973	SYM	denotes	′
T3534	9973-9975	,	denotes	,
T3535	9975-9980	NN	denotes	Csrp1
T3536	9981-9985	NN	denotes	MRE3
T3537	9985-9987	:	denotes	:
T3538	9987-9988	CD	denotes	5
T3539	9990-10017	NN	denotes	GAGATCGCCATAGGGTGCAAAGAGAAG
T3540	9988-9989	SYM	denotes	′
T3541	9989-9990	HYPH	denotes	-
T3542	10017-10018	HYPH	denotes	-
T3543	10018-10019	CD	denotes	3
T3544	10019-10020	SYM	denotes	′
T3545	10020-10021	:	denotes	;
T3546	10022-10023	CD	denotes	5
T3547	10025-10052	NN	denotes	GTGACTTCTCTTTGCACCCTATGGCGA
T3548	10023-10024	SYM	denotes	′
T3549	10024-10025	HYPH	denotes	-
T3550	10052-10053	HYPH	denotes	-
T3551	10053-10054	CD	denotes	3
T3552	10054-10055	SYM	denotes	′
T3553	10055-10057	,	denotes	,
T3554	10057-10062	NN	denotes	Csrp1
T3555	10063-10067	NN	denotes	MRE4
T3556	10067-10069	:	denotes	:
T3557	10069-10070	CD	denotes	5
T3558	10072-10099	NN	denotes	TGTCTTATTCTGGAGTGCAAGTTAGTC
T3559	10070-10071	SYM	denotes	′
T3560	10071-10072	HYPH	denotes	-
T3561	10099-10100	HYPH	denotes	-
T3562	10100-10101	CD	denotes	3
T3563	10101-10102	SYM	denotes	′
T3564	10102-10103	:	denotes	;
T3565	10104-10105	CD	denotes	5
T3566	10107-10134	NN	denotes	AGGGGACTAACTTGCACTCCAGAATAA
T3567	10105-10106	SYM	denotes	′
T3568	10106-10107	HYPH	denotes	-
T3569	10134-10135	HYPH	denotes	-
T3570	10135-10136	CD	denotes	3
T3571	10136-10137	SYM	denotes	′
T3572	10137-10139	,	denotes	,
T3573	10139-10143	NN	denotes	Gal4
T3574	10143-10145	:	denotes	:
T3575	10145-10146	CD	denotes	5
T3576	10148-10168	NN	denotes	TCCGGAGGACTGTCCTCCGG
T3577	10146-10147	SYM	denotes	′
T3578	10147-10148	HYPH	denotes	-
T3579	10168-10169	HYPH	denotes	-
T3580	10169-10170	CD	denotes	3
T3581	10170-10171	SYM	denotes	′
T3582	10171-10172	:	denotes	;
T3583	10173-10174	CD	denotes	5
T3584	10176-10196	NN	denotes	GCCGGAGGACAGTCCTCCGG
T3585	10174-10175	SYM	denotes	′
T3586	10175-10176	HYPH	denotes	-
T3587	10196-10197	HYPH	denotes	-
T3588	10197-10198	CD	denotes	3
T3589	10198-10199	SYM	denotes	′
T3590	10199-10201	,	denotes	,
T3591	10201-10205	NN	denotes	MREd
T3592	10206-10207	-LRB-	denotes	[
T3593	10207-10210	NN	denotes	MRE
T3594	10211-10218	VBN	denotes	derived
T3595	10219-10223	IN	denotes	from
T3596	10224-10229	NN	denotes	mouse
T3597	10234-10242	NN	denotes	promoter
T3598	10230-10233	NN	denotes	Mt1
T3599	10243-10244	-LRB-	denotes	(
T3600	10244-10246	CD	denotes	10
T3601	10246-10247	-RRB-	denotes	)
T3602	10247-10248	-RRB-	denotes	]
T3603	10248-10250	:	denotes	:
T3604	10250-10251	CD	denotes	5
T3605	10253-10284	NN	denotes	CGAGGGAGCTCTGCACTCCGCCCGAAAAGTG
T3606	10251-10252	SYM	denotes	′
T3607	10252-10253	HYPH	denotes	-
T3608	10284-10285	HYPH	denotes	-
T3609	10285-10286	CD	denotes	3
T3610	10286-10287	SYM	denotes	′
T3611	10287-10288	:	denotes	;
T3612	10289-10290	CD	denotes	5
T3613	10292-10331	NN	denotes	TCGACACTTTTCGGGCGGAGTGCAGAGCTCCCTCGAGCT
T3614	10290-10291	SYM	denotes	′
T3615	10291-10292	HYPH	denotes	-
T3616	10331-10332	HYPH	denotes	-
T3617	10332-10333	CD	denotes	3
T3618	10333-10334	SYM	denotes	′
T3619	10334-10336	,	denotes	,
T3620	10336-10339	NN	denotes	MRE
T3621	10340-10341	NN	denotes	s
T3622	10339-10340	HYPH	denotes	-
T3623	10342-10343	-LRB-	denotes	[
T3624	10343-10352	JJ	denotes	synthetic
T3625	10367-10375	NN	denotes	sequence
T3626	10353-10356	NN	denotes	MRE
T3627	10357-10366	NN	denotes	consensus
T3628	10376-10377	-LRB-	denotes	(
T3629	10377-10379	CD	denotes	10
T3630	10379-10380	-RRB-	denotes	)
T3631	10380-10381	-RRB-	denotes	]
T3632	10381-10383	:	denotes	:
T3633	10383-10384	CD	denotes	5
T3634	10386-10417	NN	denotes	CGAGGGAGCTCTGCACACGGCCCGAAAAGTG
T3635	10384-10385	SYM	denotes	′
T3636	10385-10386	HYPH	denotes	-
T3637	10417-10418	HYPH	denotes	-
T3638	10418-10419	CD	denotes	3
T3639	10419-10420	SYM	denotes	′
T3640	10420-10421	:	denotes	;
T3641	10422-10423	CD	denotes	5
T3642	10425-10464	NN	denotes	TCGACACTTTTCGGGCCGTGTGCAGAGCTCCCTCGAGCT
T3643	10423-10424	SYM	denotes	′
T3644	10424-10425	HYPH	denotes	-
T3645	10464-10465	HYPH	denotes	-
T3646	10465-10466	CD	denotes	3
T3647	10466-10467	SYM	denotes	′
T3648	10467-10469	,	denotes	,
T3649	10469-10474	NN	denotes	Ndrg1
T3650	10475-10479	NN	denotes	MRE1
T3651	10479-10481	:	denotes	:
T3652	10481-10482	CD	denotes	5
T3653	10484-10509	NN	denotes	CAGCCCAGGCAGGGTGCAGCACGAG
T3654	10482-10483	SYM	denotes	′
T3655	10483-10484	HYPH	denotes	-
T3656	10509-10510	HYPH	denotes	-
T3657	10510-10511	CD	denotes	3
T3658	10511-10512	SYM	denotes	′
T3659	10512-10513	:	denotes	;
T3660	10514-10515	CD	denotes	5
T3661	10517-10542	NN	denotes	CCGCCTCGTGCTGCACCCTGCCTGG
T3662	10515-10516	SYM	denotes	′
T3663	10516-10517	HYPH	denotes	-
T3664	10542-10543	HYPH	denotes	-
T3665	10543-10544	CD	denotes	3
T3666	10544-10545	SYM	denotes	′
T3667	10545-10547	,	denotes	,
T3668	10547-10552	NN	denotes	Ndrg1
T3669	10553-10557	NN	denotes	MRE2
T3670	10557-10559	:	denotes	:
T3671	10559-10560	CD	denotes	5
T3672	10562-10587	NN	denotes	CACACGTTCGCTGCACACGCCGCGG
T3673	10560-10561	SYM	denotes	′
T3674	10561-10562	HYPH	denotes	-
T3675	10587-10588	HYPH	denotes	-
T3676	10588-10589	CD	denotes	3
T3677	10589-10590	SYM	denotes	′
T3678	10590-10591	:	denotes	;
T3679	10592-10593	CD	denotes	5
T3680	10595-10620	NN	denotes	GGGACCGCGGCGTGTGCAGCGAACG
T3681	10593-10594	SYM	denotes	′
T3682	10594-10595	HYPH	denotes	-
T3683	10620-10621	HYPH	denotes	-
T3684	10621-10622	CD	denotes	3
T3685	10622-10623	SYM	denotes	′
T3686	10623-10625	,	denotes	,
T3687	10625-10630	NN	denotes	Ndrg1
T3688	10631-10635	NN	denotes	MRE3
T3689	10635-10636	,	denotes	,
T3690	10636-10637	CD	denotes	4
T3691	10637-10639	:	denotes	:
T3692	10639-10640	CD	denotes	5
T3693	10642-10681	NN	denotes	GGAGTCCTTATGCACACGCGCACGAGCGCGCACGGGCAC
T3694	10640-10641	SYM	denotes	′
T3695	10641-10642	HYPH	denotes	-
T3696	10681-10682	HYPH	denotes	-
T3697	10682-10683	CD	denotes	3
T3698	10683-10684	SYM	denotes	′
T3699	10684-10685	:	denotes	;
T3700	10686-10687	CD	denotes	5
T3701	10689-10729	NN	denotes	TGGTGTGCCCGTGCGCGCTCGTGCGCGTGTGCATAAGGAC
T3702	10687-10688	SYM	denotes	′
T3703	10688-10689	HYPH	denotes	-
T3704	10729-10730	HYPH	denotes	-
T3705	10730-10731	CD	denotes	3
T3706	10731-10732	SYM	denotes	′
T3707	10732-10734	,	denotes	,
T3708	10734-10739	NN	denotes	Sepw1
T3709	10740-10744	NN	denotes	MRE1
T3710	10744-10746	:	denotes	:
T3711	10746-10747	CD	denotes	5
T3712	10749-10782	NN	denotes	GAGGCAGTCGGCTGTGCGCACGGCCCCACGCTC
T3713	10747-10748	SYM	denotes	′
T3714	10748-10749	HYPH	denotes	-
T3715	10782-10783	HYPH	denotes	-
T3716	10783-10784	CD	denotes	3
T3717	10784-10785	SYM	denotes	′
T3718	10785-10786	:	denotes	;
T3719	10787-10788	CD	denotes	5
T3720	10790-10824	NN	denotes	CTCTGAGCGTGGGGCCGTGCGCACAGCCGACTGC
T3721	10788-10789	SYM	denotes	′
T3722	10789-10790	HYPH	denotes	-
T3723	10824-10825	HYPH	denotes	-
T3724	10825-10826	CD	denotes	3
T3725	10826-10827	SYM	denotes	′
T3726	10827-10829	,	denotes	,
T3727	10829-10834	NN	denotes	Sepw1
T3728	10835-10839	NN	denotes	MRE2
T3729	10839-10841	:	denotes	:
T3730	10841-10842	CD	denotes	5
T3731	10844-10872	NN	denotes	ATGGTTTTGGGGGTGCGCAGGGGGTCTG
T3732	10842-10843	SYM	denotes	′
T3733	10843-10844	HYPH	denotes	-
T3734	10872-10873	HYPH	denotes	-
T3735	10873-10874	CD	denotes	3
T3736	10874-10875	SYM	denotes	′
T3737	10875-10876	:	denotes	;
T3738	10877-10878	CD	denotes	5
T3739	10880-10908	NN	denotes	CGACAGACCCCCTGCGCACCCCCAAAAC
T3740	10878-10879	SYM	denotes	′
T3741	10879-10880	HYPH	denotes	-
T3742	10908-10909	HYPH	denotes	-
T3743	10909-10910	CD	denotes	3
T3744	10910-10911	SYM	denotes	′
T3745	10911-10913	,	denotes	,
T3746	10913-10921	NN	denotes	Slc39a10
T3747	10922-10926	NN	denotes	MRE1
T3748	10926-10928	:	denotes	:
T3749	10928-10929	CD	denotes	5
T3750	10931-10962	NN	denotes	GAATACACGACTGGGTGCAGCCGGGGTTTGG
T3751	10929-10930	SYM	denotes	′
T3752	10930-10931	HYPH	denotes	-
T3753	10962-10963	HYPH	denotes	-
T3754	10963-10964	CD	denotes	3
T3755	10964-10965	SYM	denotes	′
T3756	10965-10966	:	denotes	;
T3757	10967-10968	CD	denotes	5
T3758	10970-11002	NN	denotes	GGTACCAAACCCCGGCTGCACCCAGTCGTGTA
T3759	10968-10969	SYM	denotes	′
T3760	10969-10970	HYPH	denotes	-
T3761	11002-11003	HYPH	denotes	-
T3762	11003-11004	CD	denotes	3
T3763	11004-11005	SYM	denotes	′
T3764	11005-11007	,	denotes	,
T3765	11007-11015	NN	denotes	Slc39a10
T3766	11016-11020	NN	denotes	MRE2
T3767	11020-11022	:	denotes	:
T3768	11022-11023	CD	denotes	5
T3769	11025-11052	NN	denotes	GCGGAGAGGAGATGCACACGGCACTCG
T3770	11023-11024	SYM	denotes	′
T3771	11024-11025	HYPH	denotes	-
T3772	11052-11053	HYPH	denotes	-
T3773	11053-11054	CD	denotes	3
T3774	11054-11055	SYM	denotes	′
T3775	11055-11056	:	denotes	;
T3776	11057-11058	CD	denotes	5
T3777	11060-11087	NN	denotes	CACTCGAGTGCCGTGTGCATCTCCTCT
T3778	11058-11059	SYM	denotes	′
T3779	11059-11060	HYPH	denotes	-
T3780	11087-11088	HYPH	denotes	-
T3781	11088-11089	CD	denotes	3
T3782	11089-11090	SYM	denotes	′
T3783	11090-11092	,	denotes	,
T3784	11092-11103	NN	denotes	Specificity
T3785	11104-11111	NN	denotes	protein
T3786	11128-11136	NN	denotes	sequence
T3787	11112-11113	CD	denotes	1
T3788	11114-11115	-LRB-	denotes	(
T3789	11115-11118	NN	denotes	Sp1
T3790	11118-11119	-RRB-	denotes	)
T3791	11120-11127	NN	denotes	binding
T3792	11137-11138	-LRB-	denotes	(
T3793	11138-11140	CD	denotes	10
T3794	11140-11141	-RRB-	denotes	)
T3795	11141-11143	:	denotes	:
T3796	11143-11144	CD	denotes	5
T3797	11146-11161	NN	denotes	CGAGGCCCCGCCCAG
T3798	11144-11145	SYM	denotes	′
T3799	11145-11146	HYPH	denotes	-
T3800	11161-11162	HYPH	denotes	-
T3801	11162-11163	CD	denotes	3
T3802	11163-11164	SYM	denotes	′
T3803	11164-11165	:	denotes	;
T3804	11166-11167	CD	denotes	5
T3805	11169-11192	NN	denotes	TCGACTGGGCGGGGCCTCGAGct
T3806	11167-11168	SYM	denotes	′
T3807	11168-11169	HYPH	denotes	-
T3808	11192-11193	HYPH	denotes	-
T3809	11193-11194	CD	denotes	3
T3810	11194-11195	SYM	denotes	′
T3811	11195-11196	.	denotes	.
T3948	11555-11556	-LRB-	denotes	(
T3949	11556-11560	NN	denotes	SV40
T3950	11560-11561	-RRB-	denotes	)
T3951	11562-11567	JJ	denotes	large
T3952	11568-11569	NN	denotes	T
T3953	11578-11584	VBN	denotes	driven
T3954	11585-11587	IN	denotes	by
T3955	11588-11591	DT	denotes	the
T3956	11614-11622	NN	denotes	promoter
T3957	11592-11607	NN	denotes	cytomegalovirus
T3958	11608-11609	-LRB-	denotes	(
T3959	11609-11612	NN	denotes	CMV
T3960	11612-11613	-RRB-	denotes	)
T3961	11622-11624	,	denotes	,
T3962	11624-11629	VBG	denotes	using
T3963	11630-11643	NNP	denotes	lipofectamine
T3964	11645-11652	NN	denotes	reagent
T3965	11643-11644	SYM	denotes	™
T3966	11653-11654	-LRB-	denotes	(
T3967	11654-11664	NNP	denotes	Invitrogen
T3968	11664-11665	-RRB-	denotes	)
T3969	11666-11675	VBG	denotes	according
T3970	11676-11678	IN	denotes	to
T3971	11679-11682	DT	denotes	the
T3972	11683-11695	NN	denotes	manufacturer
T3973	11698-11710	NNS	denotes	instructions
T3974	11695-11697	POS	denotes	's
T3975	11710-11711	.	denotes	.
T3976	11711-11828	sentence	denotes	Cell foci were isolated and the immortalized mouse embryonic fibroblast cell line ckoC was derived from one of them.
T3977	11712-11716	NN	denotes	Cell
T3978	11717-11721	NNS	denotes	foci
T3979	11727-11735	VBN	denotes	isolated
T3980	11722-11726	VBD	denotes	were
T3981	11736-11739	CC	denotes	and
T3982	11740-11743	DT	denotes	the
T3983	11789-11793	NN	denotes	line
T3984	11744-11756	VBN	denotes	immortalized
T3985	11757-11762	NN	denotes	mouse
T3986	11773-11783	NN	denotes	fibroblast
T3987	11763-11772	JJ	denotes	embryonic
T3988	11784-11788	NN	denotes	cell
T3989	11803-11810	VBN	denotes	derived
T3990	11794-11798	NN	denotes	ckoC
T3991	11799-11802	VBD	denotes	was
T3992	11811-11815	IN	denotes	from
T3993	11816-11819	CD	denotes	one
T3994	11820-11822	IN	denotes	of
T3995	11823-11827	PRP	denotes	them
T3996	11827-11828	.	denotes	.
T3997	11828-11938	sentence	denotes	The Mtf1loxP genotype of this line as well as the genomic integration of the T antigen were confirmed by PCR.
T3998	11829-11832	DT	denotes	The
T3999	11842-11850	NN	denotes	genotype
T4000	11833-11841	NN	denotes	Mtf1loxP
T4001	11921-11930	VBN	denotes	confirmed
T4002	11851-11853	IN	denotes	of
T4003	11854-11858	DT	denotes	this
T4004	11859-11863	NN	denotes	line
T4005	11864-11866	RB	denotes	as
T4006	11872-11874	IN	denotes	as
T4007	11867-11871	RB	denotes	well
T4008	11875-11878	DT	denotes	the
T4009	11887-11898	NN	denotes	integration
T4010	11879-11886	JJ	denotes	genomic
T4011	11899-11901	IN	denotes	of
T4012	11902-11905	DT	denotes	the
T4013	11908-11915	NN	denotes	antigen
T4014	11906-11907	NN	denotes	T
T4015	11916-11920	VBD	denotes	were
T4016	11931-11933	IN	denotes	by
T4017	11934-11937	NN	denotes	PCR
T4018	11937-11938	.	denotes	.
T4019	11938-12223	sentence	denotes	100 mm plates with these cells were further transfected by the calcium phosphate method (30) with 19.6 µg of an expression plasmid for Cre recombinase driven by the CMV promoter and 0.4 µg of an expression plasmid for the neomycin resistance gene under the control of the TK promoter.
T4020	11939-11942	CD	denotes	100
T4021	11943-11945	NN	denotes	mm
T4022	11946-11952	NNS	denotes	plates
T4023	11983-11994	VBN	denotes	transfected
T4024	11953-11957	IN	denotes	with
T4025	11958-11963	DT	denotes	these
T4026	11964-11969	NNS	denotes	cells
T4027	11970-11974	VBD	denotes	were
T4028	11975-11982	RB	denotes	further
T4029	11995-11997	IN	denotes	by
T4030	11998-12001	DT	denotes	the
T4031	12020-12026	NN	denotes	method
T4032	12002-12009	NN	denotes	calcium
T4033	12010-12019	NN	denotes	phosphate
T4034	12027-12028	-LRB-	denotes	(
T4035	12028-12030	CD	denotes	30
T4036	12030-12031	-RRB-	denotes	)
T4037	12032-12036	IN	denotes	with
T4038	12037-12041	CD	denotes	19.6
T4039	12042-12044	NN	denotes	µg
T4040	12045-12047	IN	denotes	of
T4041	12048-12050	DT	denotes	an
T4042	12062-12069	NN	denotes	plasmid
T4043	12051-12061	NN	denotes	expression
T4044	12070-12073	IN	denotes	for
T4045	12074-12077	NN	denotes	Cre
T4046	12078-12089	NN	denotes	recombinase
T4047	12090-12096	VBN	denotes	driven
T4048	12097-12099	IN	denotes	by
T4049	12100-12103	DT	denotes	the
T4050	12108-12116	NN	denotes	promoter
T4051	12104-12107	NN	denotes	CMV
T4052	12117-12120	CC	denotes	and
T4053	12121-12124	CD	denotes	0.4
T4054	12125-12127	NN	denotes	µg
T4055	12128-12130	IN	denotes	of
T4056	12131-12133	DT	denotes	an
T4057	12145-12152	NN	denotes	plasmid
T4058	12134-12144	NN	denotes	expression
T4059	12153-12156	IN	denotes	for
T4060	12157-12160	DT	denotes	the
T4061	12181-12185	NN	denotes	gene
T4062	12161-12169	NN	denotes	neomycin
T4063	12170-12180	NN	denotes	resistance
T4064	12186-12191	IN	denotes	under
T4065	12192-12195	DT	denotes	the
T4066	12196-12203	NN	denotes	control
T4067	12204-12206	IN	denotes	of
T4068	12207-12210	DT	denotes	the
T4069	12214-12222	NN	denotes	promoter
T4070	12211-12213	NN	denotes	TK
T4071	12222-12223	.	denotes	.
T4072	12223-12486	sentence	denotes	Stably transfected cells were selected in the presence of 0.4 µg/µl G418 (Calbiochem), isolated clones of resistant cells were harvested and grown independently, and the expression of Cre recombinase and excision of exons 3 and 4 of Mtf1 were analyzed by RT–PCR.
T4073	12224-12230	RB	denotes	Stably
T4074	12231-12242	VBN	denotes	transfected
T4075	12243-12248	NNS	denotes	cells
T4076	12254-12262	VBN	denotes	selected
T4077	12249-12253	VBD	denotes	were
T4078	12263-12265	IN	denotes	in
T4079	12266-12269	DT	denotes	the
T4080	12270-12278	NN	denotes	presence
T4081	12279-12281	IN	denotes	of
T4082	12282-12285	CD	denotes	0.4
T4083	12286-12288	NN	denotes	µg
T4084	12292-12296	NN	denotes	G418
T4085	12288-12289	SYM	denotes	/
T4086	12289-12291	NN	denotes	µl
T4087	12297-12298	-LRB-	denotes	(
T4088	12298-12308	NNP	denotes	Calbiochem
T4089	12308-12309	-RRB-	denotes	)
T4090	12309-12311	,	denotes	,
T4091	12311-12319	VBN	denotes	isolated
T4092	12320-12326	NNS	denotes	clones
T4093	12351-12360	VBN	denotes	harvested
T4094	12327-12329	IN	denotes	of
T4095	12330-12339	JJ	denotes	resistant
T4096	12340-12345	NNS	denotes	cells
T4097	12346-12350	VBD	denotes	were
T4098	12361-12364	CC	denotes	and
T4099	12365-12370	VBN	denotes	grown
T4100	12371-12384	RB	denotes	independently
T4101	12384-12386	,	denotes	,
T4102	12386-12389	CC	denotes	and
T4103	12390-12393	DT	denotes	the
T4104	12394-12404	NN	denotes	expression
T4105	12467-12475	VBN	denotes	analyzed
T4106	12405-12407	IN	denotes	of
T4107	12408-12411	NN	denotes	Cre
T4108	12412-12423	NN	denotes	recombinase
T4109	12424-12427	CC	denotes	and
T4110	12428-12436	NN	denotes	excision
T4111	12437-12439	IN	denotes	of
T4112	12440-12445	NNS	denotes	exons
T4113	12446-12447	CD	denotes	3
T4114	12448-12451	CC	denotes	and
T4115	12452-12453	CD	denotes	4
T4116	12454-12456	IN	denotes	of
T4117	12457-12461	NN	denotes	Mtf1
T4118	12462-12466	VBD	denotes	were
T4119	12476-12478	IN	denotes	by
T4120	12479-12481	NN	denotes	RT
T4121	12482-12485	NN	denotes	PCR
T4122	12481-12482	HYPH	denotes	–
T4123	12485-12486	.	denotes	.
T4124	12486-12588	sentence	denotes	The cell lines delC19, delC21 and delC23 with a deletion of Mtf1 were chosen for further experiments.
T4125	12487-12490	DT	denotes	The
T4126	12496-12501	NNS	denotes	lines
T4127	12491-12495	NN	denotes	cell
T4128	12557-12563	VBN	denotes	chosen
T4129	12502-12508	NN	denotes	delC19
T4130	12508-12510	,	denotes	,
T4131	12510-12516	NN	denotes	delC21
T4132	12517-12520	CC	denotes	and
T4133	12521-12527	NN	denotes	delC23
T4134	12528-12532	IN	denotes	with
T4135	12533-12534	DT	denotes	a
T4136	12535-12543	NN	denotes	deletion
T4137	12544-12546	IN	denotes	of
T4138	12547-12551	NN	denotes	Mtf1
T4139	12552-12556	VBD	denotes	were
T4140	12564-12567	IN	denotes	for
T4141	12568-12575	JJ	denotes	further
T4142	12576-12587	NNS	denotes	experiments
T4143	12587-12588	.	denotes	.
T4679	13210-13220	NN	denotes	Generation
T4680	13221-13223	IN	denotes	of
T4681	13224-13226	DT	denotes	an
T4682	13273-13277	NN	denotes	line
T4683	13227-13236	JJ	denotes	inducible
T4684	13236-13238	,	denotes	,
T4685	13238-13243	NN	denotes	liver
T4686	13244-13252	JJ	denotes	specific
T4687	13243-13244	HYPH	denotes	-
T4688	13253-13257	NN	denotes	Mtf1
T4689	13258-13266	NN	denotes	knockout
T4690	13267-13272	NN	denotes	mouse
T4691	13277-13501	sentence	denotes	Using a homologous recombination strategy, mice were obtained with a modified Mtf1 allele Mtf1loxP where exons 3 and 4, encoding four of the six zinc fingers of the DNA-binding domain, are flanked by loxP sites (Figure 1a).
T4692	13278-13283	VBG	denotes	Using
T4693	13331-13339	VBN	denotes	obtained
T4694	13284-13285	DT	denotes	a
T4695	13311-13319	NN	denotes	strategy
T4696	13286-13296	JJ	denotes	homologous
T4697	13297-13310	NN	denotes	recombination
T4698	13319-13321	,	denotes	,
T4699	13321-13325	NNS	denotes	mice
T4700	13326-13330	VBD	denotes	were
T4701	13340-13344	IN	denotes	with
T4702	13345-13346	DT	denotes	a
T4703	13368-13376	NN	denotes	Mtf1loxP
T4704	13347-13355	VBN	denotes	modified
T4705	13356-13360	NN	denotes	Mtf1
T4706	13361-13367	NN	denotes	allele
T4707	13377-13382	WRB	denotes	where
T4708	13467-13474	VBN	denotes	flanked
T4709	13383-13388	NNS	denotes	exons
T4710	13389-13390	CD	denotes	3
T4711	13391-13394	CC	denotes	and
T4712	13395-13396	CD	denotes	4
T4713	13396-13398	,	denotes	,
T4714	13398-13406	VBG	denotes	encoding
T4715	13407-13411	CD	denotes	four
T4716	13412-13414	IN	denotes	of
T4717	13415-13418	DT	denotes	the
T4718	13428-13435	NNS	denotes	fingers
T4719	13419-13422	CD	denotes	six
T4720	13423-13427	NN	denotes	zinc
T4721	13436-13438	IN	denotes	of
T4722	13439-13442	DT	denotes	the
T4723	13455-13461	NN	denotes	domain
T4724	13443-13446	NN	denotes	DNA
T4725	13447-13454	VBG	denotes	binding
T4726	13446-13447	HYPH	denotes	-
T4727	13461-13463	,	denotes	,
T4728	13463-13466	VBP	denotes	are
T4729	13475-13477	IN	denotes	by
T4730	13478-13482	NN	denotes	loxP
T4731	13483-13488	NNS	denotes	sites
T4732	13489-13490	-LRB-	denotes	(
T4733	13497-13499	NN	denotes	1a
T4734	13490-13496	NN	denotes	Figure
T4735	13499-13500	-RRB-	denotes	)
T4736	13500-13501	.	denotes	.
T4737	13501-13622	sentence	denotes	Mice homozygous for the Mtf1loxP allele were further crossed with animals of the Cre recombinase transgenic line Mx-cre.
T4738	13502-13506	NNS	denotes	Mice
T4739	13555-13562	VBN	denotes	crossed
T4740	13507-13517	JJ	denotes	homozygous
T4741	13518-13521	IN	denotes	for
T4742	13522-13525	DT	denotes	the
T4743	13535-13541	NN	denotes	allele
T4744	13526-13534	NN	denotes	Mtf1loxP
T4745	13542-13546	VBD	denotes	were
T4746	13547-13554	RB	denotes	further
T4747	13563-13567	IN	denotes	with
T4748	13568-13575	NNS	denotes	animals
T4749	13576-13578	IN	denotes	of
T4750	13579-13582	DT	denotes	the
T4751	13610-13614	NN	denotes	line
T4752	13583-13586	NN	denotes	Cre
T4753	13587-13598	NN	denotes	recombinase
T4754	13599-13609	JJ	denotes	transgenic
T4755	13615-13617	NN	denotes	Mx
T4756	13618-13621	NN	denotes	cre
T4757	13617-13618	HYPH	denotes	-
T4758	13621-13622	.	denotes	.
T4759	13622-13825	sentence	denotes	Cre recombinase is expressed in this line under the control of the mouse Mx1 gene promoter, which is inducible by administration of interferon alpha or beta, or synthetic double-stranded RNA pI–pC (32).
T4760	13623-13626	NN	denotes	Cre
T4761	13627-13638	NN	denotes	recombinase
T4762	13642-13651	VBN	denotes	expressed
T4763	13639-13641	VBZ	denotes	is
T4764	13652-13654	IN	denotes	in
T4765	13655-13659	DT	denotes	this
T4766	13660-13664	NN	denotes	line
T4767	13665-13670	IN	denotes	under
T4768	13671-13674	DT	denotes	the
T4769	13675-13682	NN	denotes	control
T4770	13683-13685	IN	denotes	of
T4771	13686-13689	DT	denotes	the
T4772	13705-13713	NN	denotes	promoter
T4773	13690-13695	NN	denotes	mouse
T4774	13696-13699	NN	denotes	Mx1
T4775	13700-13704	NN	denotes	gene
T4776	13713-13715	,	denotes	,
T4777	13715-13720	WDT	denotes	which
T4778	13721-13723	VBZ	denotes	is
T4779	13724-13733	JJ	denotes	inducible
T4780	13734-13736	IN	denotes	by
T4781	13737-13751	NN	denotes	administration
T4782	13752-13754	IN	denotes	of
T4783	13755-13765	NN	denotes	interferon
T4784	13766-13771	NN	denotes	alpha
T4785	13772-13774	CC	denotes	or
T4786	13775-13779	NN	denotes	beta
T4787	13779-13781	,	denotes	,
T4788	13781-13783	CC	denotes	or
T4789	13784-13793	JJ	denotes	synthetic
T4790	13817-13819	NN	denotes	pC
T4791	13794-13800	JJ	denotes	double
T4792	13801-13809	VBN	denotes	stranded
T4793	13800-13801	HYPH	denotes	-
T4794	13810-13813	NN	denotes	RNA
T4795	13814-13816	NN	denotes	pI
T4796	13816-13817	HYPH	denotes	–
T4797	13820-13821	-LRB-	denotes	(
T4798	13821-13823	CD	denotes	32
T4799	13823-13824	-RRB-	denotes	)
T4800	13824-13825	.	denotes	.
T4801	13825-13969	sentence	denotes	Cre-mediated deletion was reported to be complete in the liver, while varying in other tissues, ranging from 94% in spleen to 8% in brain (32).
T4802	13826-13829	NN	denotes	Cre
T4803	13830-13838	VBN	denotes	mediated
T4804	13829-13830	HYPH	denotes	-
T4805	13839-13847	NN	denotes	deletion
T4806	13852-13860	VBN	denotes	reported
T4807	13848-13851	VBD	denotes	was
T4808	13861-13863	TO	denotes	to
T4809	13864-13866	VB	denotes	be
T4810	13867-13875	JJ	denotes	complete
T4811	13876-13878	IN	denotes	in
T4812	13879-13882	DT	denotes	the
T4813	13883-13888	NN	denotes	liver
T4814	13888-13890	,	denotes	,
T4815	13890-13895	IN	denotes	while
T4816	13896-13903	VBG	denotes	varying
T4817	13904-13906	IN	denotes	in
T4818	13907-13912	JJ	denotes	other
T4819	13913-13920	NNS	denotes	tissues
T4820	13920-13922	,	denotes	,
T4821	13922-13929	VBG	denotes	ranging
T4822	13930-13934	IN	denotes	from
T4823	13935-13937	CD	denotes	94
T4824	13937-13938	NN	denotes	%
T4825	13939-13941	IN	denotes	in
T4826	13942-13948	NN	denotes	spleen
T4827	13949-13951	IN	denotes	to
T4828	13952-13953	CD	denotes	8
T4829	13953-13954	NN	denotes	%
T4830	13955-13957	IN	denotes	in
T4831	13958-13963	NN	denotes	brain
T4832	13964-13965	-LRB-	denotes	(
T4833	13965-13967	CD	denotes	32
T4834	13967-13968	-RRB-	denotes	)
T4835	13968-13969	.	denotes	.
T4836	13969-14122	sentence	denotes	After Cre-mediated deletion of exons 3 and 4, which results in a frameshift and premature translation stop, no functional MTF-1 protein can be produced.
T4837	13970-13975	IN	denotes	After
T4838	14113-14121	VBN	denotes	produced
T4839	13976-13979	NN	denotes	Cre
T4840	13980-13988	VBN	denotes	mediated
T4841	13979-13980	HYPH	denotes	-
T4842	13989-13997	NN	denotes	deletion
T4843	13998-14000	IN	denotes	of
T4844	14001-14006	NNS	denotes	exons
T4845	14007-14008	CD	denotes	3
T4846	14009-14012	CC	denotes	and
T4847	14013-14014	CD	denotes	4
T4848	14014-14016	,	denotes	,
T4849	14016-14021	WDT	denotes	which
T4850	14022-14029	VBZ	denotes	results
T4851	14030-14032	IN	denotes	in
T4852	14033-14034	DT	denotes	a
T4853	14072-14076	NN	denotes	stop
T4854	14035-14045	NN	denotes	frameshift
T4855	14046-14049	CC	denotes	and
T4856	14050-14059	JJ	denotes	premature
T4857	14060-14071	NN	denotes	translation
T4858	14076-14078	,	denotes	,
T4859	14078-14080	DT	denotes	no
T4860	14098-14105	NN	denotes	protein
T4861	14081-14091	JJ	denotes	functional
T4862	14092-14095	NN	denotes	MTF
T4863	14095-14096	HYPH	denotes	-
T4864	14096-14097	CD	denotes	1
T4865	14106-14109	MD	denotes	can
T4866	14110-14112	VB	denotes	be
T4867	14121-14122	.	denotes	.
T4868	14122-14394	sentence	denotes	For induction of Cre recombinase, Mtf1 conditional knockout mice harboring the Mx-cre transgene (Mtf1Mx-cre) received four intraperitoneal pI–pC injections at 3 day intervals (pI–pC induction); control littermates without transgene (Mtf1loxP) received similar injections.
T4869	14123-14126	IN	denotes	For
T4870	14232-14240	VBD	denotes	received
T4871	14127-14136	NN	denotes	induction
T4872	14137-14139	IN	denotes	of
T4873	14140-14143	NN	denotes	Cre
T4874	14144-14155	NN	denotes	recombinase
T4875	14155-14157	,	denotes	,
T4876	14157-14161	NN	denotes	Mtf1
T4877	14183-14187	NNS	denotes	mice
T4878	14162-14173	JJ	denotes	conditional
T4879	14174-14182	NN	denotes	knockout
T4880	14188-14197	VBG	denotes	harboring
T4881	14198-14201	DT	denotes	the
T4882	14209-14218	NN	denotes	transgene
T4883	14202-14204	NN	denotes	Mx
T4884	14205-14208	NN	denotes	cre
T4885	14204-14205	HYPH	denotes	-
T4886	14219-14220	-LRB-	denotes	(
T4887	14220-14226	NN	denotes	Mtf1Mx
T4888	14227-14230	NN	denotes	cre
T4889	14226-14227	HYPH	denotes	-
T4890	14230-14231	-RRB-	denotes	)
T4891	14366-14374	VBD	denotes	received
T4892	14241-14245	CD	denotes	four
T4893	14268-14278	NNS	denotes	injections
T4894	14246-14261	JJ	denotes	intraperitoneal
T4895	14262-14264	NN	denotes	pI
T4896	14265-14267	NN	denotes	pC
T4897	14264-14265	HYPH	denotes	–
T4898	14279-14281	IN	denotes	at
T4899	14282-14283	CD	denotes	3
T4900	14284-14287	NN	denotes	day
T4901	14288-14297	NNS	denotes	intervals
T4902	14298-14299	-LRB-	denotes	(
T4903	14305-14314	NN	denotes	induction
T4904	14299-14301	NN	denotes	pI
T4905	14302-14304	NN	denotes	pC
T4906	14301-14302	HYPH	denotes	–
T4907	14314-14315	-RRB-	denotes	)
T4908	14315-14316	:	denotes	;
T4909	14317-14324	NN	denotes	control
T4910	14325-14336	NNS	denotes	littermates
T4911	14337-14344	IN	denotes	without
T4912	14345-14354	NN	denotes	transgene
T4913	14355-14356	-LRB-	denotes	(
T4914	14356-14364	NN	denotes	Mtf1loxP
T4915	14364-14365	-RRB-	denotes	)
T4916	14375-14382	JJ	denotes	similar
T4917	14383-14393	NNS	denotes	injections
T4918	14393-14394	.	denotes	.
T4919	14394-14563	sentence	denotes	Using RT–PCRs (Figure 1b), a shortened product was obtained with RNA from Mtf1Mx-cre livers, indicating a successful excision of exons 3 and 4 of Mtf1 in these animals.
T4920	14395-14400	VBG	denotes	Using
T4921	14446-14454	VBN	denotes	obtained
T4922	14401-14403	NN	denotes	RT
T4923	14404-14408	NNS	denotes	PCRs
T4924	14403-14404	HYPH	denotes	–
T4925	14409-14410	-LRB-	denotes	(
T4926	14417-14419	NN	denotes	1b
T4927	14410-14416	NN	denotes	Figure
T4928	14419-14420	-RRB-	denotes	)
T4929	14420-14422	,	denotes	,
T4930	14422-14423	DT	denotes	a
T4931	14434-14441	NN	denotes	product
T4932	14424-14433	VBN	denotes	shortened
T4933	14442-14445	VBD	denotes	was
T4934	14455-14459	IN	denotes	with
T4935	14460-14463	NN	denotes	RNA
T4936	14464-14468	IN	denotes	from
T4937	14469-14475	NN	denotes	Mtf1Mx
T4938	14476-14479	NN	denotes	cre
T4939	14475-14476	HYPH	denotes	-
T4940	14480-14486	NNS	denotes	livers
T4941	14486-14488	,	denotes	,
T4942	14488-14498	VBG	denotes	indicating
T4943	14499-14500	DT	denotes	a
T4944	14512-14520	NN	denotes	excision
T4945	14501-14511	JJ	denotes	successful
T4946	14521-14523	IN	denotes	of
T4947	14524-14529	NNS	denotes	exons
T4948	14530-14531	CD	denotes	3
T4949	14532-14535	CC	denotes	and
T4950	14536-14537	CD	denotes	4
T4951	14538-14540	IN	denotes	of
T4952	14541-14545	NN	denotes	Mtf1
T4953	14546-14548	IN	denotes	in
T4954	14549-14554	DT	denotes	these
T4955	14555-14562	NNS	denotes	animals
T4956	14562-14563	.	denotes	.
T4957	14563-14738	sentence	denotes	On close examination, a very faint band similar in size to full-length signal was also observed in those mice, probably due to a low amount of residual full-length Mtf1 mRNA.
T4958	14564-14566	IN	denotes	On
T4959	14651-14659	VBN	denotes	observed
T4960	14567-14572	JJ	denotes	close
T4961	14573-14584	NN	denotes	examination
T4962	14584-14586	,	denotes	,
T4963	14586-14587	DT	denotes	a
T4964	14599-14603	NN	denotes	band
T4965	14588-14592	RB	denotes	very
T4966	14593-14598	JJ	denotes	faint
T4967	14604-14611	JJ	denotes	similar
T4968	14612-14614	IN	denotes	in
T4969	14615-14619	NN	denotes	size
T4970	14620-14622	IN	denotes	to
T4971	14623-14627	JJ	denotes	full
T4972	14628-14634	NN	denotes	length
T4973	14627-14628	HYPH	denotes	-
T4974	14635-14641	NN	denotes	signal
T4975	14642-14645	VBD	denotes	was
T4976	14646-14650	RB	denotes	also
T4977	14660-14662	IN	denotes	in
T4978	14663-14668	DT	denotes	those
T4979	14669-14673	NNS	denotes	mice
T4980	14673-14675	,	denotes	,
T4981	14675-14683	RB	denotes	probably
T4982	14684-14687	IN	denotes	due
T4983	14688-14690	IN	denotes	to
T4984	14691-14692	DT	denotes	a
T4985	14697-14703	NN	denotes	amount
T4986	14693-14696	JJ	denotes	low
T4987	14704-14706	IN	denotes	of
T4988	14707-14715	JJ	denotes	residual
T4989	14733-14737	NN	denotes	mRNA
T4990	14716-14720	JJ	denotes	full
T4991	14721-14727	NN	denotes	length
T4992	14720-14721	HYPH	denotes	-
T4993	14728-14732	NN	denotes	Mtf1
T4994	14737-14738	.	denotes	.
T4995	14738-14988	sentence	denotes	The level of functional MTF-1 protein was examined by EMSA (Figure 1c): MTF-1 protein–DNA complex was detectable with liver protein extract from an Mtf1loxP control mouse, but no functional MRE-binding protein was observed with an Mtf1Mx-cre sample.
T4996	14739-14742	DT	denotes	The
T4997	14743-14748	NN	denotes	level
T4998	14781-14789	VBN	denotes	examined
T4999	14749-14751	IN	denotes	of
T5000	14752-14762	JJ	denotes	functional
T5001	14769-14776	NN	denotes	protein
T5002	14763-14766	NN	denotes	MTF
T5003	14766-14767	HYPH	denotes	-
T5004	14767-14768	CD	denotes	1
T5005	14777-14780	VBD	denotes	was
T5006	14837-14840	VBD	denotes	was
T5007	14790-14792	IN	denotes	by
T5008	14793-14797	NN	denotes	EMSA
T5009	14798-14799	-LRB-	denotes	(
T5010	14806-14808	NN	denotes	1c
T5011	14799-14805	NN	denotes	Figure
T5012	14808-14809	-RRB-	denotes	)
T5013	14809-14811	:	denotes	:
T5014	14811-14814	NN	denotes	MTF
T5015	14829-14836	NN	denotes	complex
T5016	14814-14815	HYPH	denotes	-
T5017	14815-14816	CD	denotes	1
T5018	14817-14824	NN	denotes	protein
T5019	14824-14825	HYPH	denotes	–
T5020	14825-14828	NN	denotes	DNA
T5021	14841-14851	JJ	denotes	detectable
T5022	14852-14856	IN	denotes	with
T5023	14857-14862	NN	denotes	liver
T5024	14871-14878	NN	denotes	extract
T5025	14863-14870	NN	denotes	protein
T5026	14879-14883	IN	denotes	from
T5027	14884-14886	DT	denotes	an
T5028	14904-14909	NN	denotes	mouse
T5029	14887-14895	NN	denotes	Mtf1loxP
T5030	14896-14903	NN	denotes	control
T5031	14909-14911	,	denotes	,
T5032	14911-14914	CC	denotes	but
T5033	14915-14917	DT	denotes	no
T5034	14941-14948	NN	denotes	protein
T5035	14918-14928	JJ	denotes	functional
T5036	14929-14932	NN	denotes	MRE
T5037	14933-14940	VBG	denotes	binding
T5038	14932-14933	HYPH	denotes	-
T5039	14953-14961	VBN	denotes	observed
T5040	14949-14952	VBD	denotes	was
T5041	14962-14966	IN	denotes	with
T5042	14967-14969	DT	denotes	an
T5043	14981-14987	NN	denotes	sample
T5044	14970-14976	NN	denotes	Mtf1Mx
T5045	14977-14980	NN	denotes	cre
T5046	14976-14977	HYPH	denotes	-
T5047	14987-14988	.	denotes	.
T5048	14988-15084	sentence	denotes	Thus, deletion of exons 3 and 4 of Mtf1 in the liver of Mtf1Mx-cre mice was virtually complete.
T5049	14989-14993	RB	denotes	Thus
T5050	15061-15064	VBD	denotes	was
T5051	14993-14995	,	denotes	,
T5052	14995-15003	NN	denotes	deletion
T5053	15004-15006	IN	denotes	of
T5054	15007-15012	NNS	denotes	exons
T5055	15013-15014	CD	denotes	3
T5056	15015-15018	CC	denotes	and
T5057	15019-15020	CD	denotes	4
T5058	15021-15023	IN	denotes	of
T5059	15024-15028	NN	denotes	Mtf1
T5060	15029-15031	IN	denotes	in
T5061	15032-15035	DT	denotes	the
T5062	15036-15041	NN	denotes	liver
T5063	15042-15044	IN	denotes	of
T5064	15045-15051	NN	denotes	Mtf1Mx
T5065	15052-15055	NN	denotes	cre
T5066	15051-15052	HYPH	denotes	-
T5067	15056-15060	NNS	denotes	mice
T5068	15065-15074	RB	denotes	virtually
T5069	15075-15083	JJ	denotes	complete
T5070	15083-15084	.	denotes	.
T5071	15084-15187	sentence	denotes	All examined liver-specific knockout mice were viable under laboratory conditions and appeared normal.
T5072	15085-15088	DT	denotes	All
T5073	15122-15126	NNS	denotes	mice
T5074	15089-15097	VBN	denotes	examined
T5075	15098-15103	NN	denotes	liver
T5076	15104-15112	JJ	denotes	specific
T5077	15103-15104	HYPH	denotes	-
T5078	15113-15121	NN	denotes	knockout
T5079	15127-15131	VBD	denotes	were
T5080	15132-15138	JJ	denotes	viable
T5081	15139-15144	IN	denotes	under
T5082	15145-15155	NN	denotes	laboratory
T5083	15156-15166	NNS	denotes	conditions
T5084	15167-15170	CC	denotes	and
T5085	15171-15179	VBD	denotes	appeared
T5086	15180-15186	JJ	denotes	normal
T5087	15186-15187	.	denotes	.
T5337	15189-15192	NN	denotes	MTF
T5338	15207-15213	NN	denotes	search
T5339	15192-15193	HYPH	denotes	-
T5340	15193-15194	CD	denotes	1
T5341	15195-15201	NN	denotes	target
T5342	15202-15206	NN	denotes	gene
T5343	15213-15443	sentence	denotes	For the identification of MTF-1 target genes, we compared the liver transcript profiles of mice with and without functional Mtf1 gene that had been mock-treated or exposed to cadmium (n = 3 per genotype and respective treatment).
T5344	15214-15217	IN	denotes	For
T5345	15263-15271	VBD	denotes	compared
T5346	15218-15221	DT	denotes	the
T5347	15222-15236	NN	denotes	identification
T5348	15237-15239	IN	denotes	of
T5349	15240-15243	NN	denotes	MTF
T5350	15253-15258	NNS	denotes	genes
T5351	15243-15244	HYPH	denotes	-
T5352	15244-15245	CD	denotes	1
T5353	15246-15252	NN	denotes	target
T5354	15258-15260	,	denotes	,
T5355	15260-15262	PRP	denotes	we
T5356	15272-15275	DT	denotes	the
T5357	15293-15301	NNS	denotes	profiles
T5358	15276-15281	NN	denotes	liver
T5359	15282-15292	NN	denotes	transcript
T5360	15302-15304	IN	denotes	of
T5361	15305-15309	NNS	denotes	mice
T5362	15310-15314	IN	denotes	with
T5363	15315-15318	CC	denotes	and
T5364	15319-15326	IN	denotes	without
T5365	15327-15337	JJ	denotes	functional
T5366	15343-15347	NN	denotes	gene
T5367	15338-15342	NN	denotes	Mtf1
T5368	15348-15352	WDT	denotes	that
T5369	15367-15374	VBN	denotes	treated
T5370	15353-15356	VBD	denotes	had
T5371	15357-15361	VBN	denotes	been
T5372	15362-15366	JJ	denotes	mock
T5373	15366-15367	HYPH	denotes	-
T5374	15375-15377	CC	denotes	or
T5375	15378-15385	VBN	denotes	exposed
T5376	15386-15388	IN	denotes	to
T5377	15389-15396	NN	denotes	cadmium
T5378	15397-15398	-LRB-	denotes	(
T5379	15402-15403	CD	denotes	3
T5380	15398-15399	NN	denotes	n
T5381	15400-15401	SYM	denotes	=
T5382	15404-15407	IN	denotes	per
T5383	15408-15416	NN	denotes	genotype
T5384	15417-15420	CC	denotes	and
T5385	15421-15431	JJ	denotes	respective
T5386	15432-15441	NN	denotes	treatment
T5387	15441-15442	-RRB-	denotes	)
T5388	15442-15443	.	denotes	.
T5389	15443-15619	sentence	denotes	In a first screen, the transcripts were analyzed with a differential display-based method, called amplification of double-stranded cDNA end restriction fragments (ADDER) (33).
T5390	15444-15446	IN	denotes	In
T5391	15484-15492	VBN	denotes	analyzed
T5392	15447-15448	DT	denotes	a
T5393	15455-15461	NN	denotes	screen
T5394	15449-15454	JJ	denotes	first
T5395	15461-15463	,	denotes	,
T5396	15463-15466	DT	denotes	the
T5397	15467-15478	NNS	denotes	transcripts
T5398	15479-15483	VBD	denotes	were
T5399	15493-15497	IN	denotes	with
T5400	15498-15499	DT	denotes	a
T5401	15527-15533	NN	denotes	method
T5402	15500-15512	JJ	denotes	differential
T5403	15513-15520	NN	denotes	display
T5404	15521-15526	VBN	denotes	based
T5405	15520-15521	HYPH	denotes	-
T5406	15533-15535	,	denotes	,
T5407	15535-15541	VBN	denotes	called
T5408	15542-15555	NN	denotes	amplification
T5409	15556-15558	IN	denotes	of
T5410	15559-15565	JJ	denotes	double
T5411	15566-15574	VBN	denotes	stranded
T5412	15565-15566	HYPH	denotes	-
T5413	15596-15605	NNS	denotes	fragments
T5414	15575-15579	NN	denotes	cDNA
T5415	15580-15583	NN	denotes	end
T5416	15584-15595	NN	denotes	restriction
T5417	15606-15607	-LRB-	denotes	(
T5418	15607-15612	NN	denotes	ADDER
T5419	15612-15613	-RRB-	denotes	)
T5420	15614-15615	-LRB-	denotes	(
T5421	15615-15617	CD	denotes	33
T5422	15617-15618	-RRB-	denotes	)
T5423	15618-15619	.	denotes	.
T5424	15619-15895	sentence	denotes	Thereby an overwhelming number of signals was obtained for the two stress-inducible metallothioneins (Mt1 and Mt2), due to the abundance of their transcripts both in mock-treated and especially in cadmium-treated livers that harbored a functional MTF-1 gene (data not shown).
T5426	15666-15674	VBN	denotes	obtained
T5427	15628-15630	DT	denotes	an
T5428	15644-15650	NN	denotes	number
T5429	15631-15643	JJ	denotes	overwhelming
T5430	15651-15653	IN	denotes	of
T5431	15654-15661	NNS	denotes	signals
T5432	15662-15665	VBD	denotes	was
T5433	15675-15678	IN	denotes	for
T5434	15679-15682	DT	denotes	the
T5435	15704-15720	NNS	denotes	metallothioneins
T5436	15683-15686	CD	denotes	two
T5437	15687-15693	NN	denotes	stress
T5438	15694-15703	JJ	denotes	inducible
T5439	15693-15694	HYPH	denotes	-
T5440	15721-15722	-LRB-	denotes	(
T5441	15722-15725	NN	denotes	Mt1
T5442	15726-15729	CC	denotes	and
T5443	15730-15733	NN	denotes	Mt2
T5444	15733-15734	-RRB-	denotes	)
T5445	15734-15736	,	denotes	,
T5446	15736-15739	IN	denotes	due
T5447	15740-15742	IN	denotes	to
T5448	15743-15746	DT	denotes	the
T5449	15747-15756	NN	denotes	abundance
T5450	15757-15759	IN	denotes	of
T5451	15760-15765	PRP$	denotes	their
T5452	15766-15777	NNS	denotes	transcripts
T5453	15778-15782	CC	denotes	both
T5454	15783-15785	IN	denotes	in
T5455	15786-15790	JJ	denotes	mock
T5456	15791-15798	VBN	denotes	treated
T5457	15790-15791	HYPH	denotes	-
T5458	15799-15802	CC	denotes	and
T5459	15803-15813	RB	denotes	especially
T5460	15814-15816	IN	denotes	in
T5461	15817-15824	NN	denotes	cadmium
T5462	15825-15832	VBN	denotes	treated
T5463	15824-15825	HYPH	denotes	-
T5464	15833-15839	NNS	denotes	livers
T5465	15840-15844	WDT	denotes	that
T5466	15845-15853	VBD	denotes	harbored
T5467	15854-15855	DT	denotes	a
T5468	15873-15877	NN	denotes	gene
T5469	15856-15866	JJ	denotes	functional
T5470	15867-15870	NN	denotes	MTF
T5471	15870-15871	HYPH	denotes	-
T5472	15871-15872	CD	denotes	1
T5473	15878-15879	-LRB-	denotes	(
T5474	15888-15893	VBN	denotes	shown
T5475	15879-15883	NNS	denotes	data
T5476	15884-15887	RB	denotes	not
T5477	15893-15894	-RRB-	denotes	)
T5478	15894-15895	.	denotes	.
T5479	15895-16011	sentence	denotes	This result confirmed the importance of MTF-1 for both basal and metal-induced expression of metallothionein genes.
T5480	15896-15900	DT	denotes	This
T5481	15901-15907	NN	denotes	result
T5482	15908-15917	VBD	denotes	confirmed
T5483	15918-15921	DT	denotes	the
T5484	15922-15932	NN	denotes	importance
T5485	15933-15935	IN	denotes	of
T5486	15936-15939	NN	denotes	MTF
T5487	15939-15940	HYPH	denotes	-
T5488	15940-15941	CD	denotes	1
T5489	15942-15945	IN	denotes	for
T5490	15946-15950	CC	denotes	both
T5491	15951-15956	JJ	denotes	basal
T5492	15975-15985	NN	denotes	expression
T5493	15957-15960	CC	denotes	and
T5494	15961-15966	NN	denotes	metal
T5495	15967-15974	VBN	denotes	induced
T5496	15966-15967	HYPH	denotes	-
T5497	15986-15988	IN	denotes	of
T5498	15989-16004	NN	denotes	metallothionein
T5499	16005-16010	NNS	denotes	genes
T5500	16010-16011	.	denotes	.
T5501	16011-16175	sentence	denotes	In a second approach, the gene expression profile in livers of the above mentioned mice was compared by Affymetrix GeneChip® Mouse Genome 430 2.0 Arrays (Table 1).
T5502	16012-16014	IN	denotes	In
T5503	16104-16112	VBN	denotes	compared
T5504	16015-16016	DT	denotes	a
T5505	16024-16032	NN	denotes	approach
T5506	16017-16023	JJ	denotes	second
T5507	16032-16034	,	denotes	,
T5508	16034-16037	DT	denotes	the
T5509	16054-16061	NN	denotes	profile
T5510	16038-16042	NN	denotes	gene
T5511	16043-16053	NN	denotes	expression
T5512	16062-16064	IN	denotes	in
T5513	16065-16071	NNS	denotes	livers
T5514	16072-16074	IN	denotes	of
T5515	16075-16078	DT	denotes	the
T5516	16095-16099	NNS	denotes	mice
T5517	16079-16084	RB	denotes	above
T5518	16085-16094	VBN	denotes	mentioned
T5519	16100-16103	VBD	denotes	was
T5520	16113-16115	IN	denotes	by
T5521	16116-16126	NNP	denotes	Affymetrix
T5522	16127-16135	NNP	denotes	GeneChip
T5523	16158-16164	NNS	denotes	Arrays
T5524	16135-16136	SYM	denotes	®
T5525	16137-16142	NNP	denotes	Mouse
T5526	16143-16149	NNP	denotes	Genome
T5527	16150-16153	CD	denotes	430
T5528	16154-16157	CD	denotes	2.0
T5529	16165-16166	-LRB-	denotes	(
T5530	16166-16171	NN	denotes	Table
T5531	16172-16173	CD	denotes	1
T5532	16173-16174	-RRB-	denotes	)
T5533	16174-16175	.	denotes	.
T5534	16175-16454	sentence	denotes	When analyzing the probe array data of livers from mock-treated Mtf1Mx-cre and Mtf1loxP mice, an at least 2-fold, reliable downregulation of expression was detected in Mtf1Mx-cre livers for 13 Affymetrix GeneChip® probe sets corresponding to 11 characterized genes (Table 1, a).
T5535	16176-16180	WRB	denotes	When
T5536	16181-16190	VBG	denotes	analyzing
T5537	16332-16340	VBN	denotes	detected
T5538	16191-16194	DT	denotes	the
T5539	16207-16211	NNS	denotes	data
T5540	16195-16200	NN	denotes	probe
T5541	16201-16206	NN	denotes	array
T5542	16212-16214	IN	denotes	of
T5543	16215-16221	NNS	denotes	livers
T5544	16222-16226	IN	denotes	from
T5545	16227-16231	JJ	denotes	mock
T5546	16232-16239	VBN	denotes	treated
T5547	16231-16232	HYPH	denotes	-
T5548	16264-16268	NNS	denotes	mice
T5549	16240-16246	NN	denotes	Mtf1Mx
T5550	16247-16250	NN	denotes	cre
T5551	16246-16247	HYPH	denotes	-
T5552	16251-16254	CC	denotes	and
T5553	16255-16263	NN	denotes	Mtf1loxP
T5554	16268-16270	,	denotes	,
T5555	16270-16272	DT	denotes	an
T5556	16299-16313	NN	denotes	downregulation
T5557	16273-16275	RB	denotes	at
T5558	16276-16281	RBS	denotes	least
T5559	16282-16288	JJ	denotes	2-fold
T5560	16288-16290	,	denotes	,
T5561	16290-16298	JJ	denotes	reliable
T5562	16314-16316	IN	denotes	of
T5563	16317-16327	NN	denotes	expression
T5564	16328-16331	VBD	denotes	was
T5565	16341-16343	IN	denotes	in
T5566	16344-16350	NN	denotes	Mtf1Mx
T5567	16351-16354	NN	denotes	cre
T5568	16350-16351	HYPH	denotes	-
T5569	16355-16361	NNS	denotes	livers
T5570	16362-16365	IN	denotes	for
T5571	16366-16368	CD	denotes	13
T5572	16396-16400	NNS	denotes	sets
T5573	16369-16379	NNP	denotes	Affymetrix
T5574	16380-16388	NNP	denotes	GeneChip
T5575	16388-16389	SYM	denotes	®
T5576	16390-16395	NN	denotes	probe
T5577	16401-16414	VBG	denotes	corresponding
T5578	16415-16417	IN	denotes	to
T5579	16418-16420	CD	denotes	11
T5580	16435-16440	NNS	denotes	genes
T5581	16421-16434	VBN	denotes	characterized
T5582	16441-16442	-LRB-	denotes	(
T5583	16451-16452	NN	denotes	a
T5584	16442-16447	NN	denotes	Table
T5585	16448-16449	CD	denotes	1
T5586	16449-16451	,	denotes	,
T5587	16452-16453	-RRB-	denotes	)
T5588	16453-16454	.	denotes	.
T5589	16454-16596	sentence	denotes	Seven of these genes contain one or more MRE core consensus sequence TGCRCNC within a segment of 1000 bp upstream of the transcription start.
T5590	16455-16460	CD	denotes	Seven
T5591	16476-16483	VBP	denotes	contain
T5592	16461-16463	IN	denotes	of
T5593	16464-16469	DT	denotes	these
T5594	16470-16475	NNS	denotes	genes
T5595	16484-16487	CD	denotes	one
T5596	16524-16531	NN	denotes	TGCRCNC
T5597	16488-16490	CC	denotes	or
T5598	16491-16495	JJR	denotes	more
T5599	16496-16499	NN	denotes	MRE
T5600	16500-16504	NN	denotes	core
T5601	16505-16514	NN	denotes	consensus
T5602	16515-16523	NN	denotes	sequence
T5603	16532-16538	IN	denotes	within
T5604	16539-16540	DT	denotes	a
T5605	16541-16548	NN	denotes	segment
T5606	16549-16551	IN	denotes	of
T5607	16552-16556	CD	denotes	1000
T5608	16557-16559	NN	denotes	bp
T5609	16560-16568	RB	denotes	upstream
T5610	16569-16571	IN	denotes	of
T5611	16572-16575	DT	denotes	the
T5612	16590-16595	NN	denotes	start
T5613	16576-16589	NN	denotes	transcription
T5614	16595-16596	.	denotes	.
T5615	16596-16837	sentence	denotes	For 26 probe sets corresponding to 24 different characterized genes, a 2-fold or higher, reliable upregulation was detected in Mtf1Mx-cre livers (Table 1, b); 17 of these 24 genes contain MRE core consensus sequences in the upstream region.
T5616	16597-16600	IN	denotes	For
T5617	16712-16720	VBN	denotes	detected
T5618	16601-16603	CD	denotes	26
T5619	16610-16614	NNS	denotes	sets
T5620	16604-16609	NN	denotes	probe
T5621	16615-16628	VBG	denotes	corresponding
T5622	16629-16631	IN	denotes	to
T5623	16632-16634	CD	denotes	24
T5624	16659-16664	NNS	denotes	genes
T5625	16635-16644	JJ	denotes	different
T5626	16645-16658	VBN	denotes	characterized
T5627	16664-16666	,	denotes	,
T5628	16666-16667	DT	denotes	a
T5629	16695-16707	NN	denotes	upregulation
T5630	16668-16674	JJ	denotes	2-fold
T5631	16675-16677	CC	denotes	or
T5632	16678-16684	JJR	denotes	higher
T5633	16684-16686	,	denotes	,
T5634	16686-16694	JJ	denotes	reliable
T5635	16708-16711	VBD	denotes	was
T5636	16777-16784	VBP	denotes	contain
T5637	16721-16723	IN	denotes	in
T5638	16724-16730	NN	denotes	Mtf1Mx
T5639	16731-16734	NN	denotes	cre
T5640	16730-16731	HYPH	denotes	-
T5641	16735-16741	NNS	denotes	livers
T5642	16742-16743	-LRB-	denotes	(
T5643	16752-16753	NN	denotes	b
T5644	16743-16748	NN	denotes	Table
T5645	16749-16750	CD	denotes	1
T5646	16750-16752	,	denotes	,
T5647	16753-16754	-RRB-	denotes	)
T5648	16754-16755	:	denotes	;
T5649	16756-16758	CD	denotes	17
T5650	16759-16761	IN	denotes	of
T5651	16762-16767	DT	denotes	these
T5652	16771-16776	NNS	denotes	genes
T5653	16768-16770	CD	denotes	24
T5654	16785-16788	NN	denotes	MRE
T5655	16789-16793	NN	denotes	core
T5656	16804-16813	NNS	denotes	sequences
T5657	16794-16803	NN	denotes	consensus
T5658	16814-16816	IN	denotes	in
T5659	16817-16820	DT	denotes	the
T5660	16830-16836	NN	denotes	region
T5661	16821-16829	JJ	denotes	upstream
T5662	16836-16837	.	denotes	.
T5663	16837-17140	sentence	denotes	The data set for livers of cadmium-treated Mtf1Mx-cre and Mtf1loxP mice revealed an at least 2-fold, reliable downregulation in Mtf1Mx-cre livers for 21 probe sets corresponding to 16 different characterized genes (Table 1, c); 10 of these contain MRE core consensus sequences in their upstream region.
T5664	16838-16841	DT	denotes	The
T5665	16847-16850	NN	denotes	set
T5666	16842-16846	NNS	denotes	data
T5667	16910-16918	VBD	denotes	revealed
T5668	16851-16854	IN	denotes	for
T5669	16855-16861	NNS	denotes	livers
T5670	16862-16864	IN	denotes	of
T5671	16865-16872	NN	denotes	cadmium
T5672	16873-16880	VBN	denotes	treated
T5673	16872-16873	HYPH	denotes	-
T5674	16905-16909	NNS	denotes	mice
T5675	16881-16887	NN	denotes	Mtf1Mx
T5676	16888-16891	NN	denotes	cre
T5677	16887-16888	HYPH	denotes	-
T5678	16892-16895	CC	denotes	and
T5679	16896-16904	NN	denotes	Mtf1loxP
T5680	17078-17085	VBP	denotes	contain
T5681	16919-16921	DT	denotes	an
T5682	16948-16962	NN	denotes	downregulation
T5683	16922-16924	RB	denotes	at
T5684	16925-16930	RBS	denotes	least
T5685	16931-16937	JJ	denotes	2-fold
T5686	16937-16939	,	denotes	,
T5687	16939-16947	JJ	denotes	reliable
T5688	16963-16965	IN	denotes	in
T5689	16966-16972	NN	denotes	Mtf1Mx
T5690	16973-16976	NN	denotes	cre
T5691	16972-16973	HYPH	denotes	-
T5692	16977-16983	NNS	denotes	livers
T5693	16984-16987	IN	denotes	for
T5694	16988-16990	CD	denotes	21
T5695	16997-17001	NNS	denotes	sets
T5696	16991-16996	NN	denotes	probe
T5697	17002-17015	VBG	denotes	corresponding
T5698	17016-17018	IN	denotes	to
T5699	17019-17021	CD	denotes	16
T5700	17046-17051	NNS	denotes	genes
T5701	17022-17031	JJ	denotes	different
T5702	17032-17045	VBN	denotes	characterized
T5703	17052-17053	-LRB-	denotes	(
T5704	17062-17063	NN	denotes	c
T5705	17053-17058	NN	denotes	Table
T5706	17059-17060	CD	denotes	1
T5707	17060-17062	,	denotes	,
T5708	17063-17064	-RRB-	denotes	)
T5709	17064-17065	:	denotes	;
T5710	17066-17068	CD	denotes	10
T5711	17069-17071	IN	denotes	of
T5712	17072-17077	DT	denotes	these
T5713	17086-17089	NN	denotes	MRE
T5714	17105-17114	NNS	denotes	sequences
T5715	17090-17094	NN	denotes	core
T5716	17095-17104	NN	denotes	consensus
T5717	17115-17117	IN	denotes	in
T5718	17118-17123	PRP$	denotes	their
T5719	17133-17139	NN	denotes	region
T5720	17124-17132	JJ	denotes	upstream
T5721	17139-17140	.	denotes	.
T5722	17140-17309	sentence	denotes	For 9 probe sets corresponding to 9 different characterized genes, an at least 2-fold, reliable upregulation was detected (Table 1, d); five of them contain MRE motifs.
T5723	17141-17144	IN	denotes	For
T5724	17254-17262	VBN	denotes	detected
T5725	17145-17146	CD	denotes	9
T5726	17153-17157	NNS	denotes	sets
T5727	17147-17152	NN	denotes	probe
T5728	17158-17171	VBG	denotes	corresponding
T5729	17172-17174	IN	denotes	to
T5730	17175-17176	CD	denotes	9
T5731	17201-17206	NNS	denotes	genes
T5732	17177-17186	JJ	denotes	different
T5733	17187-17200	VBN	denotes	characterized
T5734	17206-17208	,	denotes	,
T5735	17208-17210	DT	denotes	an
T5736	17237-17249	NN	denotes	upregulation
T5737	17211-17213	RB	denotes	at
T5738	17214-17219	RBS	denotes	least
T5739	17220-17226	JJ	denotes	2-fold
T5740	17226-17228	,	denotes	,
T5741	17228-17236	JJ	denotes	reliable
T5742	17250-17253	VBD	denotes	was
T5743	17290-17297	VBP	denotes	contain
T5744	17263-17264	-LRB-	denotes	(
T5745	17273-17274	NN	denotes	d
T5746	17264-17269	NN	denotes	Table
T5747	17270-17271	CD	denotes	1
T5748	17271-17273	,	denotes	,
T5749	17274-17275	-RRB-	denotes	)
T5750	17275-17276	:	denotes	;
T5751	17277-17281	CD	denotes	five
T5752	17282-17284	IN	denotes	of
T5753	17285-17289	PRP	denotes	them
T5754	17298-17301	NN	denotes	MRE
T5755	17302-17308	NNS	denotes	motifs
T5756	17308-17309	.	denotes	.
T5757	17309-17499	sentence	denotes	In addition to characterized genes, ESTs and RIKEN cDNA sequences were also found in the comparison of Mtf1Mx-cre and Mtf1loxP livers to be differentially expressed (Supplementary Table 1).
T5758	17310-17312	IN	denotes	In
T5759	17386-17391	VBN	denotes	found
T5760	17313-17321	NN	denotes	addition
T5761	17322-17324	IN	denotes	to
T5762	17325-17338	VBN	denotes	characterized
T5763	17339-17344	NNS	denotes	genes
T5764	17344-17346	,	denotes	,
T5765	17346-17350	NNS	denotes	ESTs
T5766	17351-17354	CC	denotes	and
T5767	17355-17360	NN	denotes	RIKEN
T5768	17361-17365	NN	denotes	cDNA
T5769	17366-17375	NNS	denotes	sequences
T5770	17376-17380	VBD	denotes	were
T5771	17381-17385	RB	denotes	also
T5772	17392-17394	IN	denotes	in
T5773	17395-17398	DT	denotes	the
T5774	17399-17409	NN	denotes	comparison
T5775	17410-17412	IN	denotes	of
T5776	17413-17419	NN	denotes	Mtf1Mx
T5777	17420-17423	NN	denotes	cre
T5778	17419-17420	HYPH	denotes	-
T5779	17437-17443	NNS	denotes	livers
T5780	17424-17427	CC	denotes	and
T5781	17428-17436	NN	denotes	Mtf1loxP
T5782	17444-17446	TO	denotes	to
T5783	17465-17474	VBN	denotes	expressed
T5784	17447-17449	VB	denotes	be
T5785	17450-17464	RB	denotes	differentially
T5786	17475-17476	-LRB-	denotes	(
T5787	17490-17495	NN	denotes	Table
T5788	17476-17489	JJ	denotes	Supplementary
T5789	17496-17497	CD	denotes	1
T5790	17497-17498	-RRB-	denotes	)
T5791	17498-17499	.	denotes	.
T5792	17499-17704	sentence	denotes	Downregulation of Mt1 and Mt2 was detected in Mtf1Mx-cre livers for both conditions (though the level of significance for the downregulation of Mt1 in mock-treated animals was above 0.05; data not shown).
T5793	17500-17514	NN	denotes	Downregulation
T5794	17534-17542	VBN	denotes	detected
T5795	17515-17517	IN	denotes	of
T5796	17518-17521	NN	denotes	Mt1
T5797	17522-17525	CC	denotes	and
T5798	17526-17529	NN	denotes	Mt2
T5799	17530-17533	VBD	denotes	was
T5800	17543-17545	IN	denotes	in
T5801	17546-17552	NN	denotes	Mtf1Mx
T5802	17553-17556	NN	denotes	cre
T5803	17552-17553	HYPH	denotes	-
T5804	17557-17563	NNS	denotes	livers
T5805	17564-17567	IN	denotes	for
T5806	17568-17572	DT	denotes	both
T5807	17573-17583	NNS	denotes	conditions
T5808	17584-17585	-LRB-	denotes	(
T5809	17585-17591	IN	denotes	though
T5810	17672-17675	VBD	denotes	was
T5811	17592-17595	DT	denotes	the
T5812	17596-17601	NN	denotes	level
T5813	17602-17604	IN	denotes	of
T5814	17605-17617	NN	denotes	significance
T5815	17618-17621	IN	denotes	for
T5816	17622-17625	DT	denotes	the
T5817	17626-17640	NN	denotes	downregulation
T5818	17641-17643	IN	denotes	of
T5819	17644-17647	NN	denotes	Mt1
T5820	17648-17650	IN	denotes	in
T5821	17651-17655	JJ	denotes	mock
T5822	17656-17663	VBN	denotes	treated
T5823	17655-17656	HYPH	denotes	-
T5824	17664-17671	NNS	denotes	animals
T5825	17676-17681	IN	denotes	above
T5826	17682-17686	CD	denotes	0.05
T5827	17686-17687	:	denotes	;
T5828	17688-17692	NNS	denotes	data
T5829	17697-17702	VBN	denotes	shown
T5830	17693-17696	RB	denotes	not
T5831	17702-17703	-RRB-	denotes	)
T5832	17703-17704	.	denotes	.
T5833	17704-17919	sentence	denotes	For all MTF-1 target genes characterized so far, such as Mt1, Mt2 and Znt1, MTF-1 exerts its transcriptional activation activity via standard MRE sequences located proximal to the transcription start (4,5,8,18,19).
T5834	17705-17708	IN	denotes	For
T5835	17787-17793	VBZ	denotes	exerts
T5836	17709-17712	DT	denotes	all
T5837	17726-17731	NNS	denotes	genes
T5838	17713-17716	NN	denotes	MTF
T5839	17716-17717	HYPH	denotes	-
T5840	17717-17718	CD	denotes	1
T5841	17719-17725	NN	denotes	target
T5842	17732-17745	VBN	denotes	characterized
T5843	17746-17748	RB	denotes	so
T5844	17749-17752	RB	denotes	far
T5845	17752-17754	,	denotes	,
T5846	17754-17758	JJ	denotes	such
T5847	17759-17761	IN	denotes	as
T5848	17762-17765	NN	denotes	Mt1
T5849	17765-17767	,	denotes	,
T5850	17767-17770	NN	denotes	Mt2
T5851	17771-17774	CC	denotes	and
T5852	17775-17779	NN	denotes	Znt1
T5853	17779-17781	,	denotes	,
T5854	17781-17784	NN	denotes	MTF
T5855	17784-17785	HYPH	denotes	-
T5856	17785-17786	CD	denotes	1
T5857	17794-17797	PRP$	denotes	its
T5858	17825-17833	NN	denotes	activity
T5859	17798-17813	JJ	denotes	transcriptional
T5860	17814-17824	NN	denotes	activation
T5861	17834-17837	IN	denotes	via
T5862	17838-17846	JJ	denotes	standard
T5863	17851-17860	NNS	denotes	sequences
T5864	17847-17850	NN	denotes	MRE
T5865	17861-17868	VBN	denotes	located
T5866	17869-17877	RB	denotes	proximal
T5867	17878-17880	IN	denotes	to
T5868	17881-17884	DT	denotes	the
T5869	17899-17904	NN	denotes	start
T5870	17885-17898	NN	denotes	transcription
T5871	17905-17906	-LRB-	denotes	(
T5872	17915-17917	CD	denotes	19
T5873	17906-17907	CD	denotes	4
T5874	17907-17908	,	denotes	,
T5875	17908-17909	CD	denotes	5
T5876	17909-17910	,	denotes	,
T5877	17910-17911	CD	denotes	8
T5878	17911-17912	,	denotes	,
T5879	17912-17914	CD	denotes	18
T5880	17914-17915	,	denotes	,
T5881	17917-17918	-RRB-	denotes	)
T5882	17918-17919	.	denotes	.
T5883	17919-18124	sentence	denotes	Even a specific search for MTF-1 binding sites by selection from a pool of double-stranded oligonucleotides with random sequences yielded no new binding motif for MTF-1 in addition to the known MREs (34).
T5884	17920-17924	RB	denotes	Even
T5885	17936-17942	NN	denotes	search
T5886	17925-17926	DT	denotes	a
T5887	17927-17935	JJ	denotes	specific
T5888	18050-18057	VBD	denotes	yielded
T5889	17943-17946	IN	denotes	for
T5890	17947-17950	NN	denotes	MTF
T5891	17961-17966	NNS	denotes	sites
T5892	17950-17951	HYPH	denotes	-
T5893	17951-17952	CD	denotes	1
T5894	17953-17960	NN	denotes	binding
T5895	17967-17969	IN	denotes	by
T5896	17970-17979	NN	denotes	selection
T5897	17980-17984	IN	denotes	from
T5898	17985-17986	DT	denotes	a
T5899	17987-17991	NN	denotes	pool
T5900	17992-17994	IN	denotes	of
T5901	17995-18001	JJ	denotes	double
T5902	18002-18010	VBN	denotes	stranded
T5903	18001-18002	HYPH	denotes	-
T5904	18011-18027	NNS	denotes	oligonucleotides
T5905	18028-18032	IN	denotes	with
T5906	18033-18039	JJ	denotes	random
T5907	18040-18049	NNS	denotes	sequences
T5908	18058-18060	DT	denotes	no
T5909	18073-18078	NN	denotes	motif
T5910	18061-18064	JJ	denotes	new
T5911	18065-18072	NN	denotes	binding
T5912	18079-18082	IN	denotes	for
T5913	18083-18086	NN	denotes	MTF
T5914	18086-18087	HYPH	denotes	-
T5915	18087-18088	CD	denotes	1
T5916	18089-18091	IN	denotes	in
T5917	18092-18100	NN	denotes	addition
T5918	18101-18103	IN	denotes	to
T5919	18104-18107	DT	denotes	the
T5920	18114-18118	NNS	denotes	MREs
T5921	18108-18113	JJ	denotes	known
T5922	18119-18120	-LRB-	denotes	(
T5923	18120-18122	CD	denotes	34
T5924	18122-18123	-RRB-	denotes	)
T5925	18123-18124	.	denotes	.
T5926	18124-18279	sentence	denotes	Thus, an MRE sequence is to date the only indication for a direct MTF-1 target gene, and four MRE-containing target gene candidates were further analyzed.
T5927	18125-18129	RB	denotes	Thus
T5928	18147-18149	VBZ	denotes	is
T5929	18129-18131	,	denotes	,
T5930	18131-18133	DT	denotes	an
T5931	18138-18146	NN	denotes	sequence
T5932	18134-18137	NN	denotes	MRE
T5933	18150-18152	IN	denotes	to
T5934	18153-18157	NN	denotes	date
T5935	18158-18161	DT	denotes	the
T5936	18167-18177	NN	denotes	indication
T5937	18162-18166	JJ	denotes	only
T5938	18178-18181	IN	denotes	for
T5939	18182-18183	DT	denotes	a
T5940	18204-18208	NN	denotes	gene
T5941	18184-18190	JJ	denotes	direct
T5942	18191-18194	NN	denotes	MTF
T5943	18194-18195	HYPH	denotes	-
T5944	18195-18196	CD	denotes	1
T5945	18197-18203	NN	denotes	target
T5946	18208-18210	,	denotes	,
T5947	18210-18213	CC	denotes	and
T5948	18214-18218	CD	denotes	four
T5949	18246-18256	NNS	denotes	candidates
T5950	18219-18222	NN	denotes	MRE
T5951	18223-18233	VBG	denotes	containing
T5952	18222-18223	HYPH	denotes	-
T5953	18234-18240	NN	denotes	target
T5954	18241-18245	NN	denotes	gene
T5955	18270-18278	VBN	denotes	analyzed
T5956	18257-18261	VBD	denotes	were
T5957	18262-18269	RB	denotes	further
T5958	18278-18279	.	denotes	.
T6000	18281-18286	JJ	denotes	Basal
T6001	18287-18297	NN	denotes	expression
T6002	18307-18314	VBZ	denotes	depends
T6003	18298-18300	IN	denotes	of
T6004	18301-18306	NN	denotes	Sepw1
T6005	18315-18317	IN	denotes	on
T6006	18318-18321	NN	denotes	MTF
T6007	18321-18322	HYPH	denotes	-
T6008	18322-18323	CD	denotes	1
T6009	18323-18473	sentence	denotes	Sepw1 was found in microarray analysis to be significantly downregulated in livers from cadmium- and mock-treated Mtf1Mx-cre mice (Table 1, a and c).
T6010	18324-18329	NN	denotes	Sepw1
T6011	18334-18339	VBN	denotes	found
T6012	18330-18333	VBD	denotes	was
T6013	18340-18342	IN	denotes	in
T6014	18343-18353	NN	denotes	microarray
T6015	18354-18362	NN	denotes	analysis
T6016	18363-18365	TO	denotes	to
T6017	18366-18368	VB	denotes	be
T6018	18369-18382	RB	denotes	significantly
T6019	18383-18396	JJ	denotes	downregulated
T6020	18397-18399	IN	denotes	in
T6021	18400-18406	NNS	denotes	livers
T6022	18407-18411	IN	denotes	from
T6023	18412-18419	NN	denotes	cadmium
T6024	18430-18437	VBN	denotes	treated
T6025	18419-18420	HYPH	denotes	-
T6026	18421-18424	CC	denotes	and
T6027	18425-18429	JJ	denotes	mock
T6028	18429-18430	HYPH	denotes	-
T6029	18449-18453	NNS	denotes	mice
T6030	18438-18444	NN	denotes	Mtf1Mx
T6031	18445-18448	NN	denotes	cre
T6032	18444-18445	HYPH	denotes	-
T6033	18454-18455	-LRB-	denotes	(
T6034	18464-18465	NN	denotes	a
T6035	18455-18460	NN	denotes	Table
T6036	18461-18462	CD	denotes	1
T6037	18462-18464	,	denotes	,
T6038	18466-18469	CC	denotes	and
T6039	18470-18471	NN	denotes	c
T6040	18471-18472	-RRB-	denotes	)
T6041	18472-18473	.	denotes	.
T6042	18473-18600	sentence	denotes	SEPW1 is a selenocysteine-containing protein that binds glutathione (35) and is thought to act as an antioxidant in vivo (36).
T6043	18474-18479	NN	denotes	SEPW1
T6044	18480-18482	VBZ	denotes	is
T6045	18483-18484	DT	denotes	a
T6046	18511-18518	NN	denotes	protein
T6047	18485-18499	NN	denotes	selenocysteine
T6048	18500-18510	VBG	denotes	containing
T6049	18499-18500	HYPH	denotes	-
T6050	18519-18523	WDT	denotes	that
T6051	18524-18529	VBZ	denotes	binds
T6052	18530-18541	NN	denotes	glutathione
T6053	18542-18543	-LRB-	denotes	(
T6054	18543-18545	CD	denotes	35
T6055	18545-18546	-RRB-	denotes	)
T6056	18547-18550	CC	denotes	and
T6057	18551-18553	VBZ	denotes	is
T6058	18554-18561	VBN	denotes	thought
T6059	18562-18564	TO	denotes	to
T6060	18565-18568	VB	denotes	act
T6061	18569-18571	IN	denotes	as
T6062	18572-18574	DT	denotes	an
T6063	18575-18586	NN	denotes	antioxidant
T6064	18587-18589	FW	denotes	in
T6065	18590-18594	FW	denotes	vivo
T6066	18595-18596	-LRB-	denotes	(
T6067	18596-18598	CD	denotes	36
T6068	18598-18599	-RRB-	denotes	)
T6069	18599-18600	.	denotes	.
T6070	18600-18783	sentence	denotes	Sepw1 expression in livers of pI–pC-induced, mock- or cadmium-treated Mtf1Mx-cre and Mtf1loxP mice was further analyzed by semiquantitative RT–PCRs and S1 analysis (Figure 2a and b).
T6071	18601-18606	NN	denotes	Sepw1
T6072	18607-18617	NN	denotes	expression
T6073	18712-18720	VBN	denotes	analyzed
T6074	18618-18620	IN	denotes	in
T6075	18621-18627	NNS	denotes	livers
T6076	18628-18630	IN	denotes	of
T6077	18631-18633	NN	denotes	pI
T6078	18634-18636	NN	denotes	pC
T6079	18633-18634	HYPH	denotes	–
T6080	18637-18644	VBN	denotes	induced
T6081	18636-18637	HYPH	denotes	-
T6082	18695-18699	NNS	denotes	mice
T6083	18644-18646	,	denotes	,
T6084	18646-18650	JJ	denotes	mock
T6085	18663-18670	VBN	denotes	treated
T6086	18650-18651	HYPH	denotes	-
T6087	18652-18654	CC	denotes	or
T6088	18655-18662	NN	denotes	cadmium
T6089	18662-18663	HYPH	denotes	-
T6090	18671-18677	NN	denotes	Mtf1Mx
T6091	18678-18681	NN	denotes	cre
T6092	18677-18678	HYPH	denotes	-
T6093	18682-18685	CC	denotes	and
T6094	18686-18694	NN	denotes	Mtf1loxP
T6095	18700-18703	VBD	denotes	was
T6096	18704-18711	RB	denotes	further
T6097	18721-18723	IN	denotes	by
T6098	18724-18740	JJ	denotes	semiquantitative
T6099	18756-18764	NN	denotes	analysis
T6100	18741-18743	NN	denotes	RT
T6101	18744-18748	NNS	denotes	PCRs
T6102	18743-18744	HYPH	denotes	–
T6103	18749-18752	CC	denotes	and
T6104	18753-18755	NN	denotes	S1
T6105	18765-18766	-LRB-	denotes	(
T6106	18773-18775	NN	denotes	2a
T6107	18766-18772	NN	denotes	Figure
T6108	18776-18779	CC	denotes	and
T6109	18780-18781	NN	denotes	b
T6110	18781-18782	-RRB-	denotes	)
T6111	18782-18783	.	denotes	.
T6112	18783-18938	sentence	denotes	In accordance with microarray data a slight, if any, upregulation of Sepw1 transcription was observed in livers from Mtf1loxP mice upon cadmium treatment.
T6113	18784-18786	IN	denotes	In
T6114	18877-18885	VBN	denotes	observed
T6115	18787-18797	NN	denotes	accordance
T6116	18798-18802	IN	denotes	with
T6117	18803-18813	NN	denotes	microarray
T6118	18814-18818	NNS	denotes	data
T6119	18819-18820	DT	denotes	a
T6120	18837-18849	NN	denotes	upregulation
T6121	18821-18827	JJ	denotes	slight
T6122	18827-18829	,	denotes	,
T6123	18832-18835	DT	denotes	any
T6124	18829-18831	IN	denotes	if
T6125	18835-18837	,	denotes	,
T6126	18850-18852	IN	denotes	of
T6127	18853-18858	NN	denotes	Sepw1
T6128	18859-18872	NN	denotes	transcription
T6129	18873-18876	VBD	denotes	was
T6130	18886-18888	IN	denotes	in
T6131	18889-18895	NNS	denotes	livers
T6132	18896-18900	IN	denotes	from
T6133	18901-18909	NN	denotes	Mtf1loxP
T6134	18910-18914	NNS	denotes	mice
T6135	18915-18919	IN	denotes	upon
T6136	18920-18927	NN	denotes	cadmium
T6137	18928-18937	NN	denotes	treatment
T6138	18937-18938	.	denotes	.
T6139	18938-19094	sentence	denotes	The basal level was reduced in livers from mock- and cadmium-treated Mtf1Mx-cre mice, indicating that MTF-1 is important for the basal expression of Sepw1.
T6140	18939-18942	DT	denotes	The
T6141	18949-18954	NN	denotes	level
T6142	18943-18948	JJ	denotes	basal
T6143	18959-18966	VBN	denotes	reduced
T6144	18955-18958	VBD	denotes	was
T6145	18967-18969	IN	denotes	in
T6146	18970-18976	NNS	denotes	livers
T6147	18977-18981	IN	denotes	from
T6148	18982-18986	JJ	denotes	mock
T6149	19000-19007	VBN	denotes	treated
T6150	18986-18987	HYPH	denotes	-
T6151	18988-18991	CC	denotes	and
T6152	18992-18999	NN	denotes	cadmium
T6153	18999-19000	HYPH	denotes	-
T6154	19019-19023	NNS	denotes	mice
T6155	19008-19014	NN	denotes	Mtf1Mx
T6156	19015-19018	NN	denotes	cre
T6157	19014-19015	HYPH	denotes	-
T6158	19023-19025	,	denotes	,
T6159	19025-19035	VBG	denotes	indicating
T6160	19036-19040	IN	denotes	that
T6161	19047-19049	VBZ	denotes	is
T6162	19041-19044	NN	denotes	MTF
T6163	19044-19045	HYPH	denotes	-
T6164	19045-19046	CD	denotes	1
T6165	19050-19059	JJ	denotes	important
T6166	19060-19063	IN	denotes	for
T6167	19064-19067	DT	denotes	the
T6168	19074-19084	NN	denotes	expression
T6169	19068-19073	JJ	denotes	basal
T6170	19085-19087	IN	denotes	of
T6171	19088-19093	NN	denotes	Sepw1
T6172	19093-19094	.	denotes	.
T6173	19094-19215	sentence	denotes	Three MRE core consensus sequences were found in the region upstream of the mouse Sepw1 transcription start (Figure 2c).
T6174	19095-19100	CD	denotes	Three
T6175	19120-19129	NNS	denotes	sequences
T6176	19101-19104	NN	denotes	MRE
T6177	19105-19109	NN	denotes	core
T6178	19110-19119	NN	denotes	consensus
T6179	19135-19140	VBN	denotes	found
T6180	19130-19134	VBD	denotes	were
T6181	19141-19143	IN	denotes	in
T6182	19144-19147	DT	denotes	the
T6183	19148-19154	NN	denotes	region
T6184	19155-19163	RB	denotes	upstream
T6185	19164-19166	IN	denotes	of
T6186	19167-19170	DT	denotes	the
T6187	19197-19202	NN	denotes	start
T6188	19171-19176	NN	denotes	mouse
T6189	19177-19182	NN	denotes	Sepw1
T6190	19183-19196	NN	denotes	transcription
T6191	19203-19204	-LRB-	denotes	(
T6192	19211-19213	NN	denotes	2c
T6193	19204-19210	NN	denotes	Figure
T6194	19213-19214	-RRB-	denotes	)
T6195	19214-19215	.	denotes	.
T6196	19215-19388	sentence	denotes	Two of them in opposite orientation overlap almost completely proximal to the transcription start (MRE1, −40 bp), the third one is located further upstream (MRE2, −527 bp).
T6197	19216-19219	CD	denotes	Two
T6198	19252-19259	VBP	denotes	overlap
T6199	19220-19222	IN	denotes	of
T6200	19223-19227	PRP	denotes	them
T6201	19228-19230	IN	denotes	in
T6202	19231-19239	JJ	denotes	opposite
T6203	19240-19251	NN	denotes	orientation
T6204	19347-19354	VBN	denotes	located
T6205	19260-19266	RB	denotes	almost
T6206	19267-19277	RB	denotes	completely
T6207	19278-19286	RB	denotes	proximal
T6208	19287-19289	IN	denotes	to
T6209	19290-19293	DT	denotes	the
T6210	19308-19313	NN	denotes	start
T6211	19294-19307	NN	denotes	transcription
T6212	19314-19315	-LRB-	denotes	(
T6213	19325-19327	NN	denotes	bp
T6214	19315-19319	NN	denotes	MRE1
T6215	19319-19321	,	denotes	,
T6216	19321-19322	SYM	denotes	−
T6217	19322-19324	CD	denotes	40
T6218	19327-19328	-RRB-	denotes	)
T6219	19328-19330	,	denotes	,
T6220	19330-19333	DT	denotes	the
T6221	19340-19343	NN	denotes	one
T6222	19334-19339	JJ	denotes	third
T6223	19344-19346	VBZ	denotes	is
T6224	19355-19362	RB	denotes	further
T6225	19363-19371	RB	denotes	upstream
T6226	19372-19373	-LRB-	denotes	(
T6227	19384-19386	NN	denotes	bp
T6228	19373-19377	NN	denotes	MRE2
T6229	19377-19379	,	denotes	,
T6230	19379-19380	SYM	denotes	−
T6231	19380-19383	CD	denotes	527
T6232	19386-19387	-RRB-	denotes	)
T6233	19387-19388	.	denotes	.
T6234	19388-19549	sentence	denotes	Specific binding of MTF-1 to Sepw1 MRE1 but not MRE2 oligonucleotide was observed in EMSA with liver protein extract from an Mtf1loxP control mouse (Figure 2d).
T6235	19389-19397	JJ	denotes	Specific
T6236	19398-19405	NN	denotes	binding
T6237	19462-19470	VBN	denotes	observed
T6238	19406-19408	IN	denotes	of
T6239	19409-19412	NN	denotes	MTF
T6240	19412-19413	HYPH	denotes	-
T6241	19413-19414	CD	denotes	1
T6242	19415-19417	IN	denotes	to
T6243	19418-19423	NN	denotes	Sepw1
T6244	19442-19457	NN	denotes	oligonucleotide
T6245	19424-19428	NN	denotes	MRE1
T6246	19429-19432	CC	denotes	but
T6247	19433-19436	RB	denotes	not
T6248	19437-19441	NN	denotes	MRE2
T6249	19458-19461	VBD	denotes	was
T6250	19471-19473	IN	denotes	in
T6251	19474-19478	NN	denotes	EMSA
T6252	19479-19483	IN	denotes	with
T6253	19484-19489	NN	denotes	liver
T6254	19490-19497	NN	denotes	protein
T6255	19498-19505	NN	denotes	extract
T6256	19506-19510	IN	denotes	from
T6257	19511-19513	DT	denotes	an
T6258	19531-19536	NN	denotes	mouse
T6259	19514-19522	NN	denotes	Mtf1loxP
T6260	19523-19530	NN	denotes	control
T6261	19537-19538	-LRB-	denotes	(
T6262	19545-19547	NN	denotes	2d
T6263	19538-19544	NN	denotes	Figure
T6264	19547-19548	-RRB-	denotes	)
T6265	19548-19549	.	denotes	.
T6266	19549-19724	sentence	denotes	As a control, no binding to MRE1 was detected with extract from a pI–pC-induced Mtf1Mx-cre mouse, confirming that the bandshift was indeed dependent on the presence of MTF-1.
T6267	19550-19552	IN	denotes	As
T6268	19587-19595	VBN	denotes	detected
T6269	19553-19554	DT	denotes	a
T6270	19555-19562	NN	denotes	control
T6271	19562-19564	,	denotes	,
T6272	19564-19566	DT	denotes	no
T6273	19567-19574	NN	denotes	binding
T6274	19575-19577	IN	denotes	to
T6275	19578-19582	NN	denotes	MRE1
T6276	19583-19586	VBD	denotes	was
T6277	19596-19600	IN	denotes	with
T6278	19601-19608	NN	denotes	extract
T6279	19609-19613	IN	denotes	from
T6280	19614-19615	DT	denotes	a
T6281	19641-19646	NN	denotes	mouse
T6282	19616-19618	NN	denotes	pI
T6283	19619-19621	NN	denotes	pC
T6284	19618-19619	HYPH	denotes	–
T6285	19622-19629	VBN	denotes	induced
T6286	19621-19622	HYPH	denotes	-
T6287	19630-19636	NN	denotes	Mtf1Mx
T6288	19637-19640	NN	denotes	cre
T6289	19636-19637	HYPH	denotes	-
T6290	19646-19648	,	denotes	,
T6291	19648-19658	VBG	denotes	confirming
T6292	19659-19663	IN	denotes	that
T6293	19678-19681	VBD	denotes	was
T6294	19664-19667	DT	denotes	the
T6295	19668-19677	NN	denotes	bandshift
T6296	19682-19688	RB	denotes	indeed
T6297	19689-19698	JJ	denotes	dependent
T6298	19699-19701	IN	denotes	on
T6299	19702-19705	DT	denotes	the
T6300	19706-19714	NN	denotes	presence
T6301	19715-19717	IN	denotes	of
T6302	19718-19721	NN	denotes	MTF
T6303	19721-19722	HYPH	denotes	-
T6304	19722-19723	CD	denotes	1
T6305	19723-19724	.	denotes	.
T6587	19726-19733	NN	denotes	Cadmium
T6588	19734-19742	NN	denotes	response
T6589	19752-19759	VBZ	denotes	depends
T6590	19743-19745	IN	denotes	of
T6591	19746-19751	NN	denotes	Ndrg1
T6592	19760-19762	IN	denotes	on
T6593	19763-19766	NN	denotes	MTF
T6594	19766-19767	HYPH	denotes	-
T6595	19767-19768	CD	denotes	1
T6596	19768-19945	sentence	denotes	Ndrg1 was significantly downregulated in microarrays of liver transcripts from cadmium-treated Mtf1Mx-cre mice compared to similarly treated Mtf1loxP control mice (Table 1, c).
T6597	19769-19774	NN	denotes	Ndrg1
T6598	19793-19806	VBN	denotes	downregulated
T6599	19775-19778	VBD	denotes	was
T6600	19779-19792	RB	denotes	significantly
T6601	19807-19809	IN	denotes	in
T6602	19810-19821	NNS	denotes	microarrays
T6603	19822-19824	IN	denotes	of
T6604	19825-19830	NN	denotes	liver
T6605	19831-19842	NNS	denotes	transcripts
T6606	19843-19847	IN	denotes	from
T6607	19848-19855	NN	denotes	cadmium
T6608	19856-19863	VBN	denotes	treated
T6609	19855-19856	HYPH	denotes	-
T6610	19875-19879	NNS	denotes	mice
T6611	19864-19870	NN	denotes	Mtf1Mx
T6612	19871-19874	NN	denotes	cre
T6613	19870-19871	HYPH	denotes	-
T6614	19880-19888	VBN	denotes	compared
T6615	19889-19891	IN	denotes	to
T6616	19892-19901	RB	denotes	similarly
T6617	19902-19909	VBN	denotes	treated
T6618	19927-19931	NNS	denotes	mice
T6619	19910-19918	NN	denotes	Mtf1loxP
T6620	19919-19926	NN	denotes	control
T6621	19932-19933	-LRB-	denotes	(
T6622	19942-19943	NN	denotes	c
T6623	19933-19938	NN	denotes	Table
T6624	19939-19940	CD	denotes	1
T6625	19940-19942	,	denotes	,
T6626	19943-19944	-RRB-	denotes	)
T6627	19944-19945	.	denotes	.
T6628	19945-20127	sentence	denotes	Ndrg1 probably has some role in stress response since various stimuli, including hypoxia and nickel compounds, activate expression of rodent Ndrg1 and/or its human ortholog (37–40).
T6629	19946-19951	NN	denotes	Ndrg1
T6630	19961-19964	VBZ	denotes	has
T6631	19952-19960	RB	denotes	probably
T6632	19965-19969	DT	denotes	some
T6633	19970-19974	NN	denotes	role
T6634	19975-19977	IN	denotes	in
T6635	19978-19984	NN	denotes	stress
T6636	19985-19993	NN	denotes	response
T6637	19994-19999	IN	denotes	since
T6638	20057-20065	VBP	denotes	activate
T6639	20000-20007	JJ	denotes	various
T6640	20008-20015	NNS	denotes	stimuli
T6641	20015-20017	,	denotes	,
T6642	20017-20026	VBG	denotes	including
T6643	20027-20034	NN	denotes	hypoxia
T6644	20046-20055	NNS	denotes	compounds
T6645	20035-20038	CC	denotes	and
T6646	20039-20045	NN	denotes	nickel
T6647	20055-20057	,	denotes	,
T6648	20066-20076	NN	denotes	expression
T6649	20077-20079	IN	denotes	of
T6650	20080-20086	NN	denotes	rodent
T6651	20087-20092	NN	denotes	Ndrg1
T6652	20093-20096	CC	denotes	and
T6653	20096-20097	HYPH	denotes	/
T6654	20097-20099	CC	denotes	or
T6655	20100-20103	PRP$	denotes	its
T6656	20110-20118	NN	denotes	ortholog
T6657	20104-20109	JJ	denotes	human
T6658	20119-20120	-LRB-	denotes	(
T6659	20120-20122	CD	denotes	37
T6660	20122-20123	SYM	denotes	–
T6661	20123-20125	CD	denotes	40
T6662	20125-20126	-RRB-	denotes	)
T6663	20126-20127	.	denotes	.
T6664	20127-20439	sentence	denotes	The Ndrg1 microarray results were confirmed with semiquantitative RT–PCRs (Figure 3a): for Mtf1loxP control livers, a clear increase of Ndrg1 expression was observed after cadmium exposure; in livers from Mtf1Mx-cre mice, this cadmium response was not detectable, while basal expression was similar to controls.
T6665	20128-20131	DT	denotes	The
T6666	20149-20156	NNS	denotes	results
T6667	20132-20137	NN	denotes	Ndrg1
T6668	20138-20148	NN	denotes	microarray
T6669	20162-20171	VBN	denotes	confirmed
T6670	20157-20161	VBD	denotes	were
T6671	20372-20375	VBD	denotes	was
T6672	20172-20176	IN	denotes	with
T6673	20177-20193	JJ	denotes	semiquantitative
T6674	20197-20201	NNS	denotes	PCRs
T6675	20194-20196	NN	denotes	RT
T6676	20196-20197	HYPH	denotes	–
T6677	20202-20203	-LRB-	denotes	(
T6678	20210-20212	NN	denotes	3a
T6679	20203-20209	NN	denotes	Figure
T6680	20212-20213	-RRB-	denotes	)
T6681	20213-20215	:	denotes	:
T6682	20215-20218	IN	denotes	for
T6683	20285-20293	VBN	denotes	observed
T6684	20219-20227	NN	denotes	Mtf1loxP
T6685	20236-20242	NNS	denotes	livers
T6686	20228-20235	NN	denotes	control
T6687	20242-20244	,	denotes	,
T6688	20244-20245	DT	denotes	a
T6689	20252-20260	NN	denotes	increase
T6690	20246-20251	JJ	denotes	clear
T6691	20261-20263	IN	denotes	of
T6692	20264-20269	NN	denotes	Ndrg1
T6693	20270-20280	NN	denotes	expression
T6694	20281-20284	VBD	denotes	was
T6695	20294-20299	IN	denotes	after
T6696	20300-20307	NN	denotes	cadmium
T6697	20308-20316	NN	denotes	exposure
T6698	20316-20317	:	denotes	;
T6699	20318-20320	IN	denotes	in
T6700	20321-20327	NNS	denotes	livers
T6701	20328-20332	IN	denotes	from
T6702	20333-20339	NN	denotes	Mtf1Mx
T6703	20340-20343	NN	denotes	cre
T6704	20339-20340	HYPH	denotes	-
T6705	20344-20348	NNS	denotes	mice
T6706	20348-20350	,	denotes	,
T6707	20350-20354	DT	denotes	this
T6708	20363-20371	NN	denotes	response
T6709	20355-20362	NN	denotes	cadmium
T6710	20376-20379	RB	denotes	not
T6711	20380-20390	JJ	denotes	detectable
T6712	20390-20392	,	denotes	,
T6713	20392-20397	IN	denotes	while
T6714	20415-20418	VBD	denotes	was
T6715	20398-20403	JJ	denotes	basal
T6716	20404-20414	NN	denotes	expression
T6717	20419-20426	JJ	denotes	similar
T6718	20427-20429	IN	denotes	to
T6719	20430-20438	NNS	denotes	controls
T6720	20438-20439	.	denotes	.
T6721	20439-20513	sentence	denotes	This indicates that cadmium-induced expression of Ndrg1 depends on MTF-1.
T6722	20440-20444	DT	denotes	This
T6723	20445-20454	VBZ	denotes	indicates
T6724	20455-20459	IN	denotes	that
T6725	20496-20503	VBZ	denotes	depends
T6726	20460-20467	NN	denotes	cadmium
T6727	20468-20475	VBN	denotes	induced
T6728	20467-20468	HYPH	denotes	-
T6729	20476-20486	NN	denotes	expression
T6730	20487-20489	IN	denotes	of
T6731	20490-20495	NN	denotes	Ndrg1
T6732	20504-20506	IN	denotes	on
T6733	20507-20510	NN	denotes	MTF
T6734	20510-20511	HYPH	denotes	-
T6735	20511-20512	CD	denotes	1
T6736	20512-20513	.	denotes	.
T6737	20513-20620	sentence	denotes	Five MRE core consensus sequences are located upstream of the mouse Ndrg1 transcription start (Figure 3b).
T6738	20514-20518	CD	denotes	Five
T6739	20538-20547	NNS	denotes	sequences
T6740	20519-20522	NN	denotes	MRE
T6741	20523-20527	NN	denotes	core
T6742	20528-20537	NN	denotes	consensus
T6743	20552-20559	VBN	denotes	located
T6744	20548-20551	VBP	denotes	are
T6745	20560-20568	RB	denotes	upstream
T6746	20569-20571	IN	denotes	of
T6747	20572-20575	DT	denotes	the
T6748	20602-20607	NN	denotes	start
T6749	20576-20581	NN	denotes	mouse
T6750	20582-20587	NN	denotes	Ndrg1
T6751	20588-20601	NN	denotes	transcription
T6752	20608-20609	-LRB-	denotes	(
T6753	20616-20618	NN	denotes	3b
T6754	20609-20615	NN	denotes	Figure
T6755	20618-20619	-RRB-	denotes	)
T6756	20619-20620	.	denotes	.
T6757	20620-20739	sentence	denotes	Four of them are clustered (MRE1 to MRE4, −138 to −332 bp), the fifth one is located farther upstream (MRE5, −883 bp).
T6758	20621-20625	CD	denotes	Four
T6759	20638-20647	VBN	denotes	clustered
T6760	20626-20628	IN	denotes	of
T6761	20629-20633	PRP	denotes	them
T6762	20634-20637	VBP	denotes	are
T6763	20698-20705	VBN	denotes	located
T6764	20648-20649	-LRB-	denotes	(
T6765	20676-20678	NN	denotes	bp
T6766	20649-20653	NN	denotes	MRE1
T6767	20654-20656	IN	denotes	to
T6768	20657-20661	NN	denotes	MRE4
T6769	20661-20663	,	denotes	,
T6770	20663-20664	SYM	denotes	−
T6771	20672-20675	CD	denotes	332
T6772	20664-20667	CD	denotes	138
T6773	20668-20670	IN	denotes	to
T6774	20671-20672	SYM	denotes	−
T6775	20678-20679	-RRB-	denotes	)
T6776	20679-20681	,	denotes	,
T6777	20681-20684	DT	denotes	the
T6778	20691-20694	CD	denotes	one
T6779	20685-20690	JJ	denotes	fifth
T6780	20695-20697	VBZ	denotes	is
T6781	20706-20713	RB	denotes	farther
T6782	20714-20722	RB	denotes	upstream
T6783	20723-20724	-LRB-	denotes	(
T6784	20735-20737	NN	denotes	bp
T6785	20724-20728	NN	denotes	MRE5
T6786	20728-20730	,	denotes	,
T6787	20730-20731	SYM	denotes	−
T6788	20731-20734	CD	denotes	883
T6789	20737-20738	-RRB-	denotes	)
T6790	20738-20739	.	denotes	.
T6791	20739-20860	sentence	denotes	EMSA was performed to test whether MTF-1 is interacting with some or all of the four proximal MRE sequences (Figure 3c).
T6792	20740-20744	NN	denotes	EMSA
T6793	20749-20758	VBN	denotes	performed
T6794	20745-20748	VBD	denotes	was
T6795	20759-20761	TO	denotes	to
T6796	20762-20766	VB	denotes	test
T6797	20767-20774	IN	denotes	whether
T6798	20784-20795	VBG	denotes	interacting
T6799	20775-20778	NN	denotes	MTF
T6800	20778-20779	HYPH	denotes	-
T6801	20779-20780	CD	denotes	1
T6802	20781-20783	VBZ	denotes	is
T6803	20796-20800	IN	denotes	with
T6804	20801-20805	DT	denotes	some
T6805	20806-20808	CC	denotes	or
T6806	20809-20812	DT	denotes	all
T6807	20813-20815	IN	denotes	of
T6808	20816-20819	DT	denotes	the
T6809	20838-20847	NNS	denotes	sequences
T6810	20820-20824	CD	denotes	four
T6811	20825-20833	JJ	denotes	proximal
T6812	20834-20837	NN	denotes	MRE
T6813	20848-20849	-LRB-	denotes	(
T6814	20856-20858	NN	denotes	3c
T6815	20849-20855	NN	denotes	Figure
T6816	20858-20859	-RRB-	denotes	)
T6817	20859-20860	.	denotes	.
T6818	20860-21006	sentence	denotes	Separate oligonucleotides were tested for MRE1 and MRE2, whereas one oligonucleotide spanning both sequences was used for MRE3 and MRE4 (MRE3,4).
T6819	20861-20869	JJ	denotes	Separate
T6820	20870-20886	NNS	denotes	oligonucleotides
T6821	20892-20898	VBN	denotes	tested
T6822	20887-20891	VBD	denotes	were
T6823	20899-20902	IN	denotes	for
T6824	20903-20907	NN	denotes	MRE1
T6825	20908-20911	CC	denotes	and
T6826	20912-20916	NN	denotes	MRE2
T6827	20916-20918	,	denotes	,
T6828	20918-20925	IN	denotes	whereas
T6829	20974-20978	VBN	denotes	used
T6830	20926-20929	CD	denotes	one
T6831	20930-20945	NN	denotes	oligonucleotide
T6832	20946-20954	VBG	denotes	spanning
T6833	20955-20959	DT	denotes	both
T6834	20960-20969	NNS	denotes	sequences
T6835	20970-20973	VBD	denotes	was
T6836	20979-20982	IN	denotes	for
T6837	20983-20987	NN	denotes	MRE3
T6838	20988-20991	CC	denotes	and
T6839	20992-20996	NN	denotes	MRE4
T6840	20997-20998	-LRB-	denotes	(
T6841	21003-21004	CD	denotes	4
T6842	20998-21002	NN	denotes	MRE3
T6843	21002-21003	,	denotes	,
T6844	21004-21005	-RRB-	denotes	)
T6845	21005-21006	.	denotes	.
T6846	21006-21177	sentence	denotes	No complex was seen with MRE1, but specific MTF-1 complexes were observed for both the MRE2 and MRE3,4 oligonucleotides with liver protein extract from an Mtf1loxP mouse.
T6847	21007-21009	DT	denotes	No
T6848	21010-21017	NN	denotes	complex
T6849	21022-21026	VBN	denotes	seen
T6850	21018-21021	VBD	denotes	was
T6851	21027-21031	IN	denotes	with
T6852	21032-21036	NN	denotes	MRE1
T6853	21036-21038	,	denotes	,
T6854	21038-21041	CC	denotes	but
T6855	21042-21050	JJ	denotes	specific
T6856	21057-21066	NNS	denotes	complexes
T6857	21051-21054	NN	denotes	MTF
T6858	21054-21055	HYPH	denotes	-
T6859	21055-21056	CD	denotes	1
T6860	21072-21080	VBN	denotes	observed
T6861	21067-21071	VBD	denotes	were
T6862	21081-21084	IN	denotes	for
T6863	21085-21089	CC	denotes	both
T6864	21094-21098	NN	denotes	MRE2
T6865	21090-21093	DT	denotes	the
T6866	21099-21102	CC	denotes	and
T6867	21103-21107	NN	denotes	MRE3
T6868	21107-21108	,	denotes	,
T6869	21108-21109	CD	denotes	4
T6870	21110-21126	NNS	denotes	oligonucleotides
T6871	21127-21131	IN	denotes	with
T6872	21132-21137	NN	denotes	liver
T6873	21146-21153	NN	denotes	extract
T6874	21138-21145	NN	denotes	protein
T6875	21154-21158	IN	denotes	from
T6876	21159-21161	DT	denotes	an
T6877	21171-21176	NN	denotes	mouse
T6878	21162-21170	NN	denotes	Mtf1loxP
T6879	21176-21177	.	denotes	.
T6880	21177-21278	sentence	denotes	As expected, no bandshift was observed with protein extract from a mouse lacking MTF-1 (Mtf1Mx-cre).
T6881	21178-21180	IN	denotes	As
T6882	21181-21189	VBN	denotes	expected
T6883	21208-21216	VBN	denotes	observed
T6884	21189-21191	,	denotes	,
T6885	21191-21193	DT	denotes	no
T6886	21194-21203	NN	denotes	bandshift
T6887	21204-21207	VBD	denotes	was
T6888	21217-21221	IN	denotes	with
T6889	21222-21229	NN	denotes	protein
T6890	21230-21237	NN	denotes	extract
T6891	21238-21242	IN	denotes	from
T6892	21243-21244	DT	denotes	a
T6893	21245-21250	NN	denotes	mouse
T6894	21251-21258	VBG	denotes	lacking
T6895	21259-21262	NN	denotes	MTF
T6896	21262-21263	HYPH	denotes	-
T6897	21263-21264	CD	denotes	1
T6898	21265-21266	-LRB-	denotes	(
T6899	21266-21272	NN	denotes	Mtf1Mx
T6900	21273-21276	NN	denotes	cre
T6901	21272-21273	HYPH	denotes	-
T6902	21276-21277	-RRB-	denotes	)
T6903	21277-21278	.	denotes	.
T7052	21876-21878	VBZ	denotes	is
T7421	22339-22342	NN	denotes	MTF
T7422	22345-22353	VBZ	denotes	inhibits
T7423	22342-22343	HYPH	denotes	-
T7424	22343-22344	CD	denotes	1
T7425	22354-22364	NN	denotes	expression
T7426	22365-22367	IN	denotes	of
T7427	22368-22376	NN	denotes	Slc39a10
T7428	22376-22563	sentence	denotes	Slc39a10 was detected in microarray analysis to be significantly upregulated in livers from both mock- and cadmium-treated Mtf1Mx-cre mice compared to control animals (Table 1, b and d).
T7429	22377-22385	NN	denotes	Slc39a10
T7430	22390-22398	VBN	denotes	detected
T7431	22386-22389	VBD	denotes	was
T7432	22399-22401	IN	denotes	in
T7433	22402-22412	NN	denotes	microarray
T7434	22413-22421	NN	denotes	analysis
T7435	22422-22424	TO	denotes	to
T7436	22442-22453	VBN	denotes	upregulated
T7437	22425-22427	VB	denotes	be
T7438	22428-22441	RB	denotes	significantly
T7439	22454-22456	IN	denotes	in
T7440	22457-22463	NNS	denotes	livers
T7441	22464-22468	IN	denotes	from
T7442	22469-22473	CC	denotes	both
T7443	22474-22478	JJ	denotes	mock
T7444	22492-22499	VBN	denotes	treated
T7445	22478-22479	HYPH	denotes	-
T7446	22480-22483	CC	denotes	and
T7447	22484-22491	NN	denotes	cadmium
T7448	22491-22492	HYPH	denotes	-
T7449	22511-22515	NNS	denotes	mice
T7450	22500-22506	NN	denotes	Mtf1Mx
T7451	22507-22510	NN	denotes	cre
T7452	22506-22507	HYPH	denotes	-
T7453	22516-22524	VBN	denotes	compared
T7454	22525-22527	IN	denotes	to
T7455	22528-22535	NN	denotes	control
T7456	22536-22543	NNS	denotes	animals
T7457	22544-22545	-LRB-	denotes	(
T7458	22554-22555	NN	denotes	b
T7459	22545-22550	NN	denotes	Table
T7460	22551-22552	CD	denotes	1
T7461	22552-22554	,	denotes	,
T7462	22556-22559	CC	denotes	and
T7463	22560-22561	NN	denotes	d
T7464	22561-22562	-RRB-	denotes	)
T7465	22562-22563	.	denotes	.
T7466	22563-22778	sentence	denotes	SLC39 proteins are members of the Zrt- and Irt-like protein (ZIP) family of metal ion transporters that transport, with no known exception, metal ion substrates across cellular membranes into the cytoplasm (43,44).
T7467	22564-22569	NN	denotes	SLC39
T7468	22570-22578	NN	denotes	proteins
T7469	22579-22582	VBP	denotes	are
T7470	22583-22590	NNS	denotes	members
T7471	22591-22593	IN	denotes	of
T7472	22594-22597	DT	denotes	the
T7473	22630-22636	NN	denotes	family
T7474	22598-22601	NN	denotes	Zrt
T7475	22611-22615	JJ	denotes	like
T7476	22601-22602	HYPH	denotes	-
T7477	22603-22606	CC	denotes	and
T7478	22607-22610	NN	denotes	Irt
T7479	22610-22611	HYPH	denotes	-
T7480	22616-22623	NN	denotes	protein
T7481	22624-22625	-LRB-	denotes	(
T7482	22625-22628	NN	denotes	ZIP
T7483	22628-22629	-RRB-	denotes	)
T7484	22637-22639	IN	denotes	of
T7485	22640-22645	NN	denotes	metal
T7486	22650-22662	NNS	denotes	transporters
T7487	22646-22649	NN	denotes	ion
T7488	22663-22667	WDT	denotes	that
T7489	22668-22677	VBP	denotes	transport
T7490	22677-22679	,	denotes	,
T7491	22679-22683	IN	denotes	with
T7492	22684-22686	DT	denotes	no
T7493	22693-22702	NN	denotes	exception
T7494	22687-22692	JJ	denotes	known
T7495	22702-22704	,	denotes	,
T7496	22704-22709	NN	denotes	metal
T7497	22710-22713	NN	denotes	ion
T7498	22714-22724	NNS	denotes	substrates
T7499	22725-22731	IN	denotes	across
T7500	22732-22740	JJ	denotes	cellular
T7501	22741-22750	NNS	denotes	membranes
T7502	22751-22755	IN	denotes	into
T7503	22756-22759	DT	denotes	the
T7504	22760-22769	NN	denotes	cytoplasm
T7505	22770-22771	-LRB-	denotes	(
T7506	22774-22776	CD	denotes	44
T7507	22771-22773	CD	denotes	43
T7508	22773-22774	,	denotes	,
T7509	22776-22777	-RRB-	denotes	)
T7510	22777-22778	.	denotes	.
T7511	22778-22936	sentence	denotes	In accordance with microarray data, semiquantitative RT–PCRs showed a downregulation of Slc39a10 expression in livers of Mtf1loxP mice upon cadmium exposure.
T7512	22779-22781	IN	denotes	In
T7513	22840-22846	VBD	denotes	showed
T7514	22782-22792	NN	denotes	accordance
T7515	22793-22797	IN	denotes	with
T7516	22798-22808	NN	denotes	microarray
T7517	22809-22813	NNS	denotes	data
T7518	22813-22815	,	denotes	,
T7519	22815-22831	JJ	denotes	semiquantitative
T7520	22835-22839	NNS	denotes	PCRs
T7521	22832-22834	NN	denotes	RT
T7522	22834-22835	HYPH	denotes	–
T7523	22847-22848	DT	denotes	a
T7524	22849-22863	NN	denotes	downregulation
T7525	22864-22866	IN	denotes	of
T7526	22867-22875	NN	denotes	Slc39a10
T7527	22876-22886	NN	denotes	expression
T7528	22887-22889	IN	denotes	in
T7529	22890-22896	NNS	denotes	livers
T7530	22897-22899	IN	denotes	of
T7531	22900-22908	NN	denotes	Mtf1loxP
T7532	22909-22913	NNS	denotes	mice
T7533	22914-22918	IN	denotes	upon
T7534	22919-22926	NN	denotes	cadmium
T7535	22927-22935	NN	denotes	exposure
T7536	22935-22936	.	denotes	.
T7537	22936-23102	sentence	denotes	In samples from Mtf1Mx-cre mice, the basal expression was significantly increased; cadmium treatment still resulted in a decrease of Slc39a10 expression (Figure 5a).
T7538	22937-22939	IN	denotes	In
T7539	23009-23018	VBN	denotes	increased
T7540	22940-22947	NNS	denotes	samples
T7541	22948-22952	IN	denotes	from
T7542	22953-22959	NN	denotes	Mtf1Mx
T7543	22960-22963	NN	denotes	cre
T7544	22959-22960	HYPH	denotes	-
T7545	22964-22968	NNS	denotes	mice
T7546	22968-22970	,	denotes	,
T7547	22970-22973	DT	denotes	the
T7548	22980-22990	NN	denotes	expression
T7549	22974-22979	JJ	denotes	basal
T7550	22991-22994	VBD	denotes	was
T7551	22995-23008	RB	denotes	significantly
T7552	23044-23052	VBD	denotes	resulted
T7553	23018-23019	:	denotes	;
T7554	23020-23027	NN	denotes	cadmium
T7555	23028-23037	NN	denotes	treatment
T7556	23038-23043	RB	denotes	still
T7557	23053-23055	IN	denotes	in
T7558	23056-23057	DT	denotes	a
T7559	23058-23066	NN	denotes	decrease
T7560	23067-23069	IN	denotes	of
T7561	23070-23078	NN	denotes	Slc39a10
T7562	23079-23089	NN	denotes	expression
T7563	23090-23091	-LRB-	denotes	(
T7564	23098-23100	NN	denotes	5a
T7565	23091-23097	NN	denotes	Figure
T7566	23100-23101	-RRB-	denotes	)
T7567	23101-23102	.	denotes	.
T7568	23102-23296	sentence	denotes	It cannot be judged by this experiment whether the degree of cadmium-induced reduction of Slc39a10 transcription was identical for Mtf1Mx-cre and Mtf1loxP mice or lower in the absence of MTF-1.
T7569	23103-23105	PRP	denotes	It
T7570	23116-23122	VBN	denotes	judged
T7571	23106-23109	MD	denotes	can
T7572	23109-23112	RB	denotes	not
T7573	23113-23115	VB	denotes	be
T7574	23123-23125	IN	denotes	by
T7575	23126-23130	DT	denotes	this
T7576	23131-23141	NN	denotes	experiment
T7577	23142-23149	IN	denotes	whether
T7578	23216-23219	VBD	denotes	was
T7579	23150-23153	DT	denotes	the
T7580	23154-23160	NN	denotes	degree
T7581	23161-23163	IN	denotes	of
T7582	23164-23171	NN	denotes	cadmium
T7583	23172-23179	VBN	denotes	induced
T7584	23171-23172	HYPH	denotes	-
T7585	23180-23189	NN	denotes	reduction
T7586	23190-23192	IN	denotes	of
T7587	23193-23201	NN	denotes	Slc39a10
T7588	23202-23215	NN	denotes	transcription
T7589	23220-23229	JJ	denotes	identical
T7590	23230-23233	IN	denotes	for
T7591	23234-23240	NN	denotes	Mtf1Mx
T7592	23241-23244	NN	denotes	cre
T7593	23240-23241	HYPH	denotes	-
T7594	23258-23262	NNS	denotes	mice
T7595	23245-23248	CC	denotes	and
T7596	23249-23257	NN	denotes	Mtf1loxP
T7597	23263-23265	CC	denotes	or
T7598	23266-23271	JJR	denotes	lower
T7599	23272-23274	IN	denotes	in
T7600	23275-23278	DT	denotes	the
T7601	23279-23286	NN	denotes	absence
T7602	23287-23289	IN	denotes	of
T7603	23290-23293	NN	denotes	MTF
T7604	23293-23294	HYPH	denotes	-
T7605	23294-23295	CD	denotes	1
T7606	23295-23296	.	denotes	.
T7607	23296-23491	sentence	denotes	In microarray analysis, the degree of the downregulation was either comparable to the one in control livers or lower, depending on the considered Affymetrix GeneChip® probe set (data not shown).
T7608	23297-23299	IN	denotes	In
T7609	23354-23357	VBD	denotes	was
T7610	23300-23310	NN	denotes	microarray
T7611	23311-23319	NN	denotes	analysis
T7612	23319-23321	,	denotes	,
T7613	23321-23324	DT	denotes	the
T7614	23325-23331	NN	denotes	degree
T7615	23332-23334	IN	denotes	of
T7616	23335-23338	DT	denotes	the
T7617	23339-23353	NN	denotes	downregulation
T7618	23358-23364	CC	denotes	either
T7619	23365-23375	JJ	denotes	comparable
T7620	23376-23378	IN	denotes	to
T7621	23379-23382	DT	denotes	the
T7622	23383-23386	NN	denotes	one
T7623	23387-23389	IN	denotes	in
T7624	23390-23397	NN	denotes	control
T7625	23398-23404	NNS	denotes	livers
T7626	23405-23407	CC	denotes	or
T7627	23408-23413	JJR	denotes	lower
T7628	23413-23415	,	denotes	,
T7629	23415-23424	VBG	denotes	depending
T7630	23425-23427	IN	denotes	on
T7631	23428-23431	DT	denotes	the
T7632	23470-23473	NN	denotes	set
T7633	23432-23442	VBN	denotes	considered
T7634	23443-23453	NNP	denotes	Affymetrix
T7635	23454-23462	NNP	denotes	GeneChip
T7636	23462-23463	SYM	denotes	®
T7637	23464-23469	NN	denotes	probe
T7638	23474-23475	-LRB-	denotes	(
T7639	23484-23489	VBN	denotes	shown
T7640	23475-23479	NNS	denotes	data
T7641	23480-23483	RB	denotes	not
T7642	23489-23490	-RRB-	denotes	)
T7643	23490-23491	.	denotes	.
T7644	23491-23586	sentence	denotes	The results indicate that MTF-1 is involved in repression of the basal expression of Slc39a10.
T7645	23492-23495	DT	denotes	The
T7646	23496-23503	NNS	denotes	results
T7647	23504-23512	VBP	denotes	indicate
T7648	23513-23517	IN	denotes	that
T7649	23527-23535	VBN	denotes	involved
T7650	23518-23521	NN	denotes	MTF
T7651	23521-23522	HYPH	denotes	-
T7652	23522-23523	CD	denotes	1
T7653	23524-23526	VBZ	denotes	is
T7654	23536-23538	IN	denotes	in
T7655	23539-23549	NN	denotes	repression
T7656	23550-23552	IN	denotes	of
T7657	23553-23556	DT	denotes	the
T7658	23563-23573	NN	denotes	expression
T7659	23557-23562	JJ	denotes	basal
T7660	23574-23576	IN	denotes	of
T7661	23577-23585	NN	denotes	Slc39a10
T7662	23585-23586	.	denotes	.
T7663	23586-23700	sentence	denotes	It might also participate in the cadmium response of this gene, but it is apparently not exclusively responsible.
T7664	23587-23589	PRP	denotes	It
T7665	23601-23612	VB	denotes	participate
T7666	23590-23595	MD	denotes	might
T7667	23596-23600	RB	denotes	also
T7668	23613-23615	IN	denotes	in
T7669	23616-23619	DT	denotes	the
T7670	23628-23636	NN	denotes	response
T7671	23620-23627	NN	denotes	cadmium
T7672	23637-23639	IN	denotes	of
T7673	23640-23644	DT	denotes	this
T7674	23645-23649	NN	denotes	gene
T7675	23649-23651	,	denotes	,
T7676	23651-23654	CC	denotes	but
T7677	23655-23657	PRP	denotes	it
T7678	23658-23660	VBZ	denotes	is
T7679	23661-23671	RB	denotes	apparently
T7680	23672-23675	RB	denotes	not
T7681	23676-23687	RB	denotes	exclusively
T7682	23688-23699	JJ	denotes	responsible
T7683	23699-23700	.	denotes	.
T7684	23700-23873	sentence	denotes	One MRE core consensus sequence was found just upstream of the mouse Slc39a10 transcription start (MRE1, −21 bp), another one directly downstream (MRE2, +17 bp; Figure 5b).
T7685	23701-23704	CD	denotes	One
T7686	23724-23732	NN	denotes	sequence
T7687	23705-23708	NN	denotes	MRE
T7688	23709-23713	NN	denotes	core
T7689	23714-23723	NN	denotes	consensus
T7690	23737-23742	VBN	denotes	found
T7691	23733-23736	VBD	denotes	was
T7692	23823-23826	NN	denotes	one
T7693	23743-23747	RB	denotes	just
T7694	23748-23756	RB	denotes	upstream
T7695	23757-23759	IN	denotes	of
T7696	23760-23763	DT	denotes	the
T7697	23793-23798	NN	denotes	start
T7698	23764-23769	NN	denotes	mouse
T7699	23770-23778	NN	denotes	Slc39a10
T7700	23779-23792	NN	denotes	transcription
T7701	23799-23800	-LRB-	denotes	(
T7702	23810-23812	NN	denotes	bp
T7703	23800-23804	NN	denotes	MRE1
T7704	23804-23806	,	denotes	,
T7705	23806-23807	SYM	denotes	−
T7706	23807-23809	CD	denotes	21
T7707	23812-23813	-RRB-	denotes	)
T7708	23813-23815	,	denotes	,
T7709	23815-23822	DT	denotes	another
T7710	23827-23835	RB	denotes	directly
T7711	23836-23846	JJ	denotes	downstream
T7712	23847-23848	-LRB-	denotes	(
T7713	23869-23871	NN	denotes	5b
T7714	23848-23852	NN	denotes	MRE2
T7715	23852-23854	,	denotes	,
T7716	23854-23855	SYM	denotes	+
T7717	23855-23857	CD	denotes	17
T7718	23858-23860	NN	denotes	bp
T7719	23860-23861	:	denotes	;
T7720	23862-23868	NN	denotes	Figure
T7721	23871-23872	-RRB-	denotes	)
T7722	23872-23873	.	denotes	.
T7723	23873-24069	sentence	denotes	Specific binding of MTF-1 was observed in EMSA analysis for MRE2 with liver protein extract from an Mtf1loxP but not from an Mtf1Mx-cre mouse, while no binding was detected with MRE1 (Figure 5c).
T7724	23874-23882	JJ	denotes	Specific
T7725	23883-23890	NN	denotes	binding
T7726	23904-23912	VBN	denotes	observed
T7727	23891-23893	IN	denotes	of
T7728	23894-23897	NN	denotes	MTF
T7729	23897-23898	HYPH	denotes	-
T7730	23898-23899	CD	denotes	1
T7731	23900-23903	VBD	denotes	was
T7732	23913-23915	IN	denotes	in
T7733	23916-23920	NN	denotes	EMSA
T7734	23921-23929	NN	denotes	analysis
T7735	23930-23933	IN	denotes	for
T7736	23934-23938	NN	denotes	MRE2
T7737	23939-23943	IN	denotes	with
T7738	23944-23949	NN	denotes	liver
T7739	23958-23965	NN	denotes	extract
T7740	23950-23957	NN	denotes	protein
T7741	23966-23970	IN	denotes	from
T7742	23971-23973	DT	denotes	an
T7743	23974-23982	NN	denotes	Mtf1loxP
T7744	23983-23986	CC	denotes	but
T7745	23987-23990	RB	denotes	not
T7746	23991-23995	IN	denotes	from
T7747	23996-23998	DT	denotes	an
T7748	24010-24015	NN	denotes	mouse
T7749	23999-24005	NN	denotes	Mtf1Mx
T7750	24006-24009	NN	denotes	cre
T7751	24005-24006	HYPH	denotes	-
T7752	24015-24017	,	denotes	,
T7753	24017-24022	IN	denotes	while
T7754	24038-24046	VBN	denotes	detected
T7755	24023-24025	DT	denotes	no
T7756	24026-24033	NN	denotes	binding
T7757	24034-24037	VBD	denotes	was
T7758	24047-24051	IN	denotes	with
T7759	24052-24056	NN	denotes	MRE1
T7760	24057-24058	-LRB-	denotes	(
T7761	24065-24067	NN	denotes	5c
T7762	24058-24064	NN	denotes	Figure
T7763	24067-24068	-RRB-	denotes	)
T7764	24068-24069	.	denotes	.
T8110	24071-24078	NN	denotes	Cadmium
T8111	24079-24089	JJ	denotes	responsive
T8112	24078-24079	HYPH	denotes	-
T8113	24109-24114	NNS	denotes	genes
T8114	24089-24091	,	denotes	,
T8115	24091-24094	NN	denotes	MTF
T8116	24097-24108	JJ	denotes	independent
T8117	24094-24095	HYPH	denotes	-
T8118	24095-24096	CD	denotes	1
T8119	24096-24097	HYPH	denotes	-
T8120	24114-24362	sentence	denotes	Finally, we also identified a number of cadmium-responsive genes that were independent of MTF-1 presence, by comparing the probe array data of all cadmium-treated mice with the data of all mock-treated mice, irrespective of the genotype (Table 2).
T8121	24115-24122	RB	denotes	Finally
T8122	24132-24142	VBD	denotes	identified
T8123	24122-24124	,	denotes	,
T8124	24124-24126	PRP	denotes	we
T8125	24127-24131	RB	denotes	also
T8126	24143-24144	DT	denotes	a
T8127	24145-24151	NN	denotes	number
T8128	24152-24154	IN	denotes	of
T8129	24155-24162	NN	denotes	cadmium
T8130	24163-24173	JJ	denotes	responsive
T8131	24162-24163	HYPH	denotes	-
T8132	24174-24179	NNS	denotes	genes
T8133	24180-24184	WDT	denotes	that
T8134	24185-24189	VBD	denotes	were
T8135	24190-24201	JJ	denotes	independent
T8136	24202-24204	IN	denotes	of
T8137	24205-24208	NN	denotes	MTF
T8138	24211-24219	NN	denotes	presence
T8139	24208-24209	HYPH	denotes	-
T8140	24209-24210	CD	denotes	1
T8141	24219-24221	,	denotes	,
T8142	24221-24223	IN	denotes	by
T8143	24224-24233	VBG	denotes	comparing
T8144	24234-24237	DT	denotes	the
T8145	24250-24254	NNS	denotes	data
T8146	24238-24243	NN	denotes	probe
T8147	24244-24249	NN	denotes	array
T8148	24255-24257	IN	denotes	of
T8149	24258-24261	DT	denotes	all
T8150	24278-24282	NNS	denotes	mice
T8151	24262-24269	NN	denotes	cadmium
T8152	24270-24277	VBN	denotes	treated
T8153	24269-24270	HYPH	denotes	-
T8154	24283-24287	IN	denotes	with
T8155	24288-24291	DT	denotes	the
T8156	24292-24296	NNS	denotes	data
T8157	24297-24299	IN	denotes	of
T8158	24300-24303	DT	denotes	all
T8159	24317-24321	NNS	denotes	mice
T8160	24304-24308	JJ	denotes	mock
T8161	24309-24316	VBN	denotes	treated
T8162	24308-24309	HYPH	denotes	-
T8163	24321-24323	,	denotes	,
T8164	24323-24335	RB	denotes	irrespective
T8165	24336-24338	IN	denotes	of
T8166	24339-24342	DT	denotes	the
T8167	24343-24351	NN	denotes	genotype
T8168	24352-24353	-LRB-	denotes	(
T8169	24353-24358	NN	denotes	Table
T8170	24359-24360	CD	denotes	2
T8171	24360-24361	-RRB-	denotes	)
T8172	24361-24362	.	denotes	.
T8173	24362-24522	sentence	denotes	An at least 2-fold, reliable upregulation was observed after cadmium exposure for 31 probe sets corresponding to 21 different characterized genes (Table 2, a).
T8174	24363-24365	DT	denotes	An
T8175	24392-24404	NN	denotes	upregulation
T8176	24366-24368	RB	denotes	at
T8177	24369-24374	RBS	denotes	least
T8178	24375-24381	JJ	denotes	2-fold
T8179	24381-24383	,	denotes	,
T8180	24383-24391	JJ	denotes	reliable
T8181	24409-24417	VBN	denotes	observed
T8182	24405-24408	VBD	denotes	was
T8183	24418-24423	IN	denotes	after
T8184	24424-24431	NN	denotes	cadmium
T8185	24432-24440	NN	denotes	exposure
T8186	24441-24444	IN	denotes	for
T8187	24445-24447	CD	denotes	31
T8188	24454-24458	NNS	denotes	sets
T8189	24448-24453	NN	denotes	probe
T8190	24459-24472	VBG	denotes	corresponding
T8191	24473-24475	IN	denotes	to
T8192	24476-24478	CD	denotes	21
T8193	24503-24508	NNS	denotes	genes
T8194	24479-24488	JJ	denotes	different
T8195	24489-24502	VBN	denotes	characterized
T8196	24509-24510	-LRB-	denotes	(
T8197	24519-24520	NN	denotes	a
T8198	24510-24515	NN	denotes	Table
T8199	24516-24517	CD	denotes	2
T8200	24517-24519	,	denotes	,
T8201	24520-24521	-RRB-	denotes	)
T8202	24521-24522	.	denotes	.
T8203	24522-24640	sentence	denotes	For 2 probe sets corresponding to 2 characterized genes, an at least 2-fold downregulation was detected (Table 2, b).
T8204	24523-24526	IN	denotes	For
T8205	24618-24626	VBN	denotes	detected
T8206	24527-24528	CD	denotes	2
T8207	24535-24539	NNS	denotes	sets
T8208	24529-24534	NN	denotes	probe
T8209	24540-24553	VBG	denotes	corresponding
T8210	24554-24556	IN	denotes	to
T8211	24557-24558	CD	denotes	2
T8212	24573-24578	NNS	denotes	genes
T8213	24559-24572	VBN	denotes	characterized
T8214	24578-24580	,	denotes	,
T8215	24580-24582	DT	denotes	an
T8216	24599-24613	NN	denotes	downregulation
T8217	24583-24585	RB	denotes	at
T8218	24586-24591	RBS	denotes	least
T8219	24592-24598	JJ	denotes	2-fold
T8220	24614-24617	VBD	denotes	was
T8221	24627-24628	-LRB-	denotes	(
T8222	24637-24638	NN	denotes	b
T8223	24628-24633	NN	denotes	Table
T8224	24634-24635	CD	denotes	2
T8225	24635-24637	,	denotes	,
T8226	24638-24639	-RRB-	denotes	)
T8227	24639-24640	.	denotes	.
T8228	24640-25148	sentence	denotes	Several genes involved in the metabolism of the antioxidant glutathione were found to be upregulated by cadmium exposure, namely the genes encoding the catalytic subunit of glutamate-cysteine ligase (Gclc) that is the rate limiting enzyme in de novo synthesis of glutathione (45); glutathione reductase 1 (Gsr), the reducing enzyme for oxidized glutathione (45); and glutathione-S-transferase, mu 4 (Gstm4), which is a member of the glutathione-S-transferase supergene family of detoxification enzymes (45).
T8229	24641-24648	JJ	denotes	Several
T8230	24649-24654	NNS	denotes	genes
T8231	24718-24723	VBN	denotes	found
T8232	24655-24663	VBN	denotes	involved
T8233	24664-24666	IN	denotes	in
T8234	24667-24670	DT	denotes	the
T8235	24671-24681	NN	denotes	metabolism
T8236	24682-24684	IN	denotes	of
T8237	24685-24688	DT	denotes	the
T8238	24701-24712	NN	denotes	glutathione
T8239	24689-24700	NN	denotes	antioxidant
T8240	24713-24717	VBD	denotes	were
T8241	24724-24726	TO	denotes	to
T8242	24730-24741	VBN	denotes	upregulated
T8243	24727-24729	VB	denotes	be
T8244	24742-24744	IN	denotes	by
T8245	24745-24752	NN	denotes	cadmium
T8246	24753-24761	NN	denotes	exposure
T8247	24761-24763	,	denotes	,
T8248	24763-24769	RB	denotes	namely
T8249	24774-24779	NNS	denotes	genes
T8250	24770-24773	DT	denotes	the
T8251	24780-24788	VBG	denotes	encoding
T8252	24789-24792	DT	denotes	the
T8253	24803-24810	NN	denotes	subunit
T8254	24793-24802	JJ	denotes	catalytic
T8255	24811-24813	IN	denotes	of
T8256	24814-24823	NN	denotes	glutamate
T8257	24833-24839	NN	denotes	ligase
T8258	24823-24824	HYPH	denotes	-
T8259	24824-24832	NN	denotes	cysteine
T8260	24840-24841	-LRB-	denotes	(
T8261	24841-24845	NN	denotes	Gclc
T8262	24845-24846	-RRB-	denotes	)
T8263	24847-24851	WDT	denotes	that
T8264	24852-24854	VBZ	denotes	is
T8265	24855-24858	DT	denotes	the
T8266	24873-24879	NN	denotes	enzyme
T8267	24859-24863	NN	denotes	rate
T8268	24864-24872	VBG	denotes	limiting
T8269	24880-24882	IN	denotes	in
T8270	24883-24885	FW	denotes	de
T8271	24886-24890	FW	denotes	novo
T8272	24891-24900	NN	denotes	synthesis
T8273	24901-24903	IN	denotes	of
T8274	24904-24915	NN	denotes	glutathione
T8275	24916-24917	-LRB-	denotes	(
T8276	24917-24919	CD	denotes	45
T8277	24919-24920	-RRB-	denotes	)
T8278	24920-24921	:	denotes	;
T8279	24922-24933	NN	denotes	glutathione
T8280	24934-24943	NN	denotes	reductase
T8281	24944-24945	CD	denotes	1
T8282	24946-24947	-LRB-	denotes	(
T8283	24947-24950	NN	denotes	Gsr
T8284	24950-24951	-RRB-	denotes	)
T8285	24951-24953	,	denotes	,
T8286	24953-24956	DT	denotes	the
T8287	24966-24972	NN	denotes	enzyme
T8288	24957-24965	VBG	denotes	reducing
T8289	24973-24976	IN	denotes	for
T8290	24977-24985	VBN	denotes	oxidized
T8291	24986-24997	NN	denotes	glutathione
T8292	24998-24999	-LRB-	denotes	(
T8293	24999-25001	CD	denotes	45
T8294	25001-25002	-RRB-	denotes	)
T8295	25002-25003	:	denotes	;
T8296	25004-25007	CC	denotes	and
T8297	25008-25019	NN	denotes	glutathione
T8298	25022-25033	NN	denotes	transferase
T8299	25019-25020	HYPH	denotes	-
T8300	25020-25021	NN	denotes	S
T8301	25021-25022	HYPH	denotes	-
T8302	25033-25035	,	denotes	,
T8303	25035-25037	NN	denotes	mu
T8304	25041-25046	NN	denotes	Gstm4
T8305	25038-25039	CD	denotes	4
T8306	25040-25041	-LRB-	denotes	(
T8307	25046-25047	-RRB-	denotes	)
T8308	25047-25049	,	denotes	,
T8309	25049-25054	WDT	denotes	which
T8310	25055-25057	VBZ	denotes	is
T8311	25058-25059	DT	denotes	a
T8312	25060-25066	NN	denotes	member
T8313	25067-25069	IN	denotes	of
T8314	25070-25073	DT	denotes	the
T8315	25110-25116	NN	denotes	family
T8316	25074-25085	NN	denotes	glutathione
T8317	25088-25099	NN	denotes	transferase
T8318	25085-25086	HYPH	denotes	-
T8319	25086-25087	NN	denotes	S
T8320	25087-25088	HYPH	denotes	-
T8321	25100-25109	NN	denotes	supergene
T8322	25117-25119	IN	denotes	of
T8323	25120-25134	NN	denotes	detoxification
T8324	25135-25142	NNS	denotes	enzymes
T8325	25143-25144	-LRB-	denotes	(
T8326	25144-25146	CD	denotes	45
T8327	25146-25147	-RRB-	denotes	)
T8328	25147-25148	.	denotes	.
T8329	25148-25241	sentence	denotes	In all of these cases, induction was confirmed by semiquantitative RT–PCRs (data not shown).
T8330	25149-25151	IN	denotes	In
T8331	25186-25195	VBN	denotes	confirmed
T8332	25152-25155	DT	denotes	all
T8333	25156-25158	IN	denotes	of
T8334	25159-25164	DT	denotes	these
T8335	25165-25170	NNS	denotes	cases
T8336	25170-25172	,	denotes	,
T8337	25172-25181	NN	denotes	induction
T8338	25182-25185	VBD	denotes	was
T8339	25196-25198	IN	denotes	by
T8340	25199-25215	JJ	denotes	semiquantitative
T8341	25219-25223	NNS	denotes	PCRs
T8342	25216-25218	NN	denotes	RT
T8343	25218-25219	HYPH	denotes	–
T8344	25224-25225	-LRB-	denotes	(
T8345	25234-25239	VBN	denotes	shown
T8346	25225-25229	NNS	denotes	data
T8347	25230-25233	RB	denotes	not
T8348	25239-25240	-RRB-	denotes	)
T8349	25240-25241	.	denotes	.
T8350	25241-25396	sentence	denotes	Gclc, also referred to as heavy chain subunit of gamma-glutamylcysteine synthetase (Ggcs-hc), had been discussed previously as a target gene of MTF-1 (6).
T8351	25242-25246	NN	denotes	Gclc
T8352	25345-25354	VBN	denotes	discussed
T8353	25246-25248	,	denotes	,
T8354	25248-25252	RB	denotes	also
T8355	25253-25261	VBN	denotes	referred
T8356	25262-25264	IN	denotes	to
T8357	25265-25267	IN	denotes	as
T8358	25268-25273	JJ	denotes	heavy
T8359	25274-25279	NN	denotes	chain
T8360	25280-25287	NN	denotes	subunit
T8361	25288-25290	IN	denotes	of
T8362	25291-25296	NN	denotes	gamma
T8363	25297-25313	NN	denotes	glutamylcysteine
T8364	25296-25297	HYPH	denotes	-
T8365	25314-25324	NN	denotes	synthetase
T8366	25325-25326	-LRB-	denotes	(
T8367	25326-25330	NN	denotes	Ggcs
T8368	25331-25333	NN	denotes	hc
T8369	25330-25331	HYPH	denotes	-
T8370	25333-25334	-RRB-	denotes	)
T8371	25334-25336	,	denotes	,
T8372	25336-25339	VBD	denotes	had
T8373	25340-25344	VBN	denotes	been
T8374	25355-25365	RB	denotes	previously
T8375	25366-25368	IN	denotes	as
T8376	25369-25370	DT	denotes	a
T8377	25378-25382	NN	denotes	gene
T8378	25371-25377	NN	denotes	target
T8379	25383-25385	IN	denotes	of
T8380	25386-25389	NN	denotes	MTF
T8381	25389-25390	HYPH	denotes	-
T8382	25390-25391	CD	denotes	1
T8383	25392-25393	-LRB-	denotes	(
T8384	25393-25394	CD	denotes	6
T8385	25394-25395	-RRB-	denotes	)
T8386	25395-25396	.	denotes	.
T8387	25396-25521	sentence	denotes	Our expression data indicate that Gclc is induced by cadmium but, at least in the adult mouse liver, not dependent on MTF-1.
T8388	25397-25400	PRP$	denotes	Our
T8389	25412-25416	NNS	denotes	data
T8390	25401-25411	NN	denotes	expression
T8391	25417-25425	VBP	denotes	indicate
T8392	25426-25430	IN	denotes	that
T8393	25439-25446	VBN	denotes	induced
T8394	25431-25435	NN	denotes	Gclc
T8395	25436-25438	VBZ	denotes	is
T8396	25447-25449	IN	denotes	by
T8397	25450-25457	NN	denotes	cadmium
T8398	25458-25461	CC	denotes	but
T8399	25461-25463	,	denotes	,
T8400	25463-25465	RB	denotes	at
T8401	25466-25471	RBS	denotes	least
T8402	25472-25474	IN	denotes	in
T8403	25502-25511	JJ	denotes	dependent
T8404	25475-25478	DT	denotes	the
T8405	25491-25496	NN	denotes	liver
T8406	25479-25484	JJ	denotes	adult
T8407	25485-25490	NN	denotes	mouse
T8408	25496-25498	,	denotes	,
T8409	25498-25501	RB	denotes	not
T8410	25512-25514	IN	denotes	on
T8411	25515-25518	NN	denotes	MTF
T8412	25518-25519	HYPH	denotes	-
T8413	25519-25520	CD	denotes	1
T8414	25520-25521	.	denotes	.
T8415	25521-25871	sentence	denotes	To analyze the role of the glutathione system in the cellular cadmium response, mouse embryonic fibroblasts with and without functional Mtf1 were treated with cadmium in combination with BSO, a specific inhibitor of glutamate-cysteine ligase (31), and cell viability was assessed by a colorimetric assay based on the tetrazolium salt MTT (Figure 6).
T8416	25522-25524	TO	denotes	To
T8417	25525-25532	VB	denotes	analyze
T8418	25668-25675	VBN	denotes	treated
T8419	25533-25536	DT	denotes	the
T8420	25537-25541	NN	denotes	role
T8421	25542-25544	IN	denotes	of
T8422	25545-25548	DT	denotes	the
T8423	25561-25567	NN	denotes	system
T8424	25549-25560	NN	denotes	glutathione
T8425	25568-25570	IN	denotes	in
T8426	25571-25574	DT	denotes	the
T8427	25592-25600	NN	denotes	response
T8428	25575-25583	JJ	denotes	cellular
T8429	25584-25591	NN	denotes	cadmium
T8430	25600-25602	,	denotes	,
T8431	25602-25607	NN	denotes	mouse
T8432	25618-25629	NNS	denotes	fibroblasts
T8433	25608-25617	JJ	denotes	embryonic
T8434	25630-25634	IN	denotes	with
T8435	25635-25638	CC	denotes	and
T8436	25639-25646	IN	denotes	without
T8437	25647-25657	JJ	denotes	functional
T8438	25658-25662	NN	denotes	Mtf1
T8439	25663-25667	VBD	denotes	were
T8440	25676-25680	IN	denotes	with
T8441	25681-25688	NN	denotes	cadmium
T8442	25689-25691	IN	denotes	in
T8443	25692-25703	NN	denotes	combination
T8444	25704-25708	IN	denotes	with
T8445	25709-25712	NN	denotes	BSO
T8446	25712-25714	,	denotes	,
T8447	25714-25715	DT	denotes	a
T8448	25725-25734	NN	denotes	inhibitor
T8449	25716-25724	JJ	denotes	specific
T8450	25735-25737	IN	denotes	of
T8451	25738-25747	NN	denotes	glutamate
T8452	25748-25756	NN	denotes	cysteine
T8453	25747-25748	HYPH	denotes	-
T8454	25757-25763	NN	denotes	ligase
T8455	25764-25765	-LRB-	denotes	(
T8456	25765-25767	CD	denotes	31
T8457	25767-25768	-RRB-	denotes	)
T8458	25768-25770	,	denotes	,
T8459	25770-25773	CC	denotes	and
T8460	25774-25778	NN	denotes	cell
T8461	25779-25788	NN	denotes	viability
T8462	25793-25801	VBN	denotes	assessed
T8463	25789-25792	VBD	denotes	was
T8464	25802-25804	IN	denotes	by
T8465	25805-25806	DT	denotes	a
T8466	25820-25825	NN	denotes	assay
T8467	25807-25819	JJ	denotes	colorimetric
T8468	25826-25831	VBN	denotes	based
T8469	25832-25834	IN	denotes	on
T8470	25835-25838	DT	denotes	the
T8471	25851-25855	NN	denotes	salt
T8472	25839-25850	NN	denotes	tetrazolium
T8473	25856-25859	NN	denotes	MTT
T8474	25860-25861	-LRB-	denotes	(
T8475	25861-25867	NN	denotes	Figure
T8476	25868-25869	CD	denotes	6
T8477	25869-25870	-RRB-	denotes	)
T8478	25870-25871	.	denotes	.
T8479	25871-25980	sentence	denotes	Increasing concentrations of BSO or cadmium alone were to some extent cytotoxic for the examined cell lines.
T8480	25872-25882	VBG	denotes	Increasing
T8481	25883-25897	NNS	denotes	concentrations
T8482	25922-25926	VBD	denotes	were
T8483	25898-25900	IN	denotes	of
T8484	25901-25904	NN	denotes	BSO
T8485	25905-25907	CC	denotes	or
T8486	25908-25915	NN	denotes	cadmium
T8487	25916-25921	RB	denotes	alone
T8488	25927-25929	IN	denotes	to
T8489	25930-25934	DT	denotes	some
T8490	25935-25941	NN	denotes	extent
T8491	25942-25951	JJ	denotes	cytotoxic
T8492	25952-25955	IN	denotes	for
T8493	25956-25959	DT	denotes	the
T8494	25974-25979	NNS	denotes	lines
T8495	25960-25968	VBN	denotes	examined
T8496	25969-25973	NN	denotes	cell
T8497	25979-25980	.	denotes	.
T8498	25980-26216	sentence	denotes	Treatment with both BSO and cadmium resulted in an enhanced lethality particularly for the cells without functional Mtf1, indicating that a depletion of glutathione together with a lack of Mtf1 impair an efficient anti-cadmium defense.
T8499	25981-25990	NN	denotes	Treatment
T8500	26017-26025	VBD	denotes	resulted
T8501	25991-25995	IN	denotes	with
T8502	25996-26000	CC	denotes	both
T8503	26001-26004	NN	denotes	BSO
T8504	26005-26008	CC	denotes	and
T8505	26009-26016	NN	denotes	cadmium
T8506	26026-26028	IN	denotes	in
T8507	26029-26031	DT	denotes	an
T8508	26041-26050	NN	denotes	lethality
T8509	26032-26040	VBN	denotes	enhanced
T8510	26051-26063	RB	denotes	particularly
T8511	26064-26067	IN	denotes	for
T8512	26068-26071	DT	denotes	the
T8513	26072-26077	NNS	denotes	cells
T8514	26078-26085	IN	denotes	without
T8515	26086-26096	JJ	denotes	functional
T8516	26097-26101	NN	denotes	Mtf1
T8517	26101-26103	,	denotes	,
T8518	26103-26113	VBG	denotes	indicating
T8519	26114-26118	IN	denotes	that
T8520	26175-26181	VBP	denotes	impair
T8521	26119-26120	DT	denotes	a
T8522	26121-26130	NN	denotes	depletion
T8523	26131-26133	IN	denotes	of
T8524	26134-26145	NN	denotes	glutathione
T8525	26146-26154	RB	denotes	together
T8526	26155-26159	IN	denotes	with
T8527	26160-26161	DT	denotes	a
T8528	26162-26166	NN	denotes	lack
T8529	26167-26169	IN	denotes	of
T8530	26170-26174	NN	denotes	Mtf1
T8531	26182-26184	DT	denotes	an
T8532	26208-26215	NN	denotes	defense
T8533	26185-26194	JJ	denotes	efficient
T8534	26195-26207	JJ	denotes	anti-cadmium
T8535	26215-26216	.	denotes	.
T8536	26216-26353	sentence	denotes	Thus, adequate glutathione supply as well as MTF-1 and its target genes are essential for the survival of the cell under cadmium stress.
T8537	26217-26221	RB	denotes	Thus
T8538	26289-26292	VBP	denotes	are
T8539	26221-26223	,	denotes	,
T8540	26223-26231	JJ	denotes	adequate
T8541	26244-26250	NN	denotes	supply
T8542	26232-26243	NN	denotes	glutathione
T8543	26251-26253	RB	denotes	as
T8544	26259-26261	IN	denotes	as
T8545	26254-26258	RB	denotes	well
T8546	26262-26265	NN	denotes	MTF
T8547	26265-26266	HYPH	denotes	-
T8548	26266-26267	CD	denotes	1
T8549	26268-26271	CC	denotes	and
T8550	26272-26275	PRP$	denotes	its
T8551	26283-26288	NNS	denotes	genes
T8552	26276-26282	NN	denotes	target
T8553	26293-26302	JJ	denotes	essential
T8554	26303-26306	IN	denotes	for
T8555	26307-26310	DT	denotes	the
T8556	26311-26319	NN	denotes	survival
T8557	26320-26322	IN	denotes	of
T8558	26323-26326	DT	denotes	the
T8559	26327-26331	NN	denotes	cell
T8560	26332-26337	IN	denotes	under
T8561	26338-26345	NN	denotes	cadmium
T8562	26346-26352	NN	denotes	stress
T8563	26352-26353	.	denotes	.
T8564	26353-26806	sentence	denotes	Besides genes related to the glutathione pathway, several other stress-related genes were upregulated upon cadmium exposure, including genes for thioredoxin reductase 1 (Txnrd1), one of the reducing enzymes of the antioxidant thioredoxin (46); KDEL endoplasmic reticulum protein retention receptor 2 (Kdelr2) participating in ER stress response (47); and the anti-apoptotic Bcl2-associated athanogene 3 (Bag3) involved in stress-induced apoptosis (48).
T8565	26354-26361	IN	denotes	Besides
T8566	26444-26455	VBN	denotes	upregulated
T8567	26362-26367	NNS	denotes	genes
T8568	26368-26375	VBN	denotes	related
T8569	26376-26378	IN	denotes	to
T8570	26379-26382	DT	denotes	the
T8571	26395-26402	NN	denotes	pathway
T8572	26383-26394	NN	denotes	glutathione
T8573	26402-26404	,	denotes	,
T8574	26404-26411	JJ	denotes	several
T8575	26433-26438	NNS	denotes	genes
T8576	26412-26417	JJ	denotes	other
T8577	26418-26424	NN	denotes	stress
T8578	26425-26432	VBN	denotes	related
T8579	26424-26425	HYPH	denotes	-
T8580	26439-26443	VBD	denotes	were
T8581	26456-26460	IN	denotes	upon
T8582	26461-26468	NN	denotes	cadmium
T8583	26469-26477	NN	denotes	exposure
T8584	26477-26479	,	denotes	,
T8585	26479-26488	VBG	denotes	including
T8586	26489-26494	NNS	denotes	genes
T8587	26495-26498	IN	denotes	for
T8588	26499-26510	NN	denotes	thioredoxin
T8589	26511-26520	NN	denotes	reductase
T8590	26521-26522	CD	denotes	1
T8591	26523-26524	-LRB-	denotes	(
T8592	26524-26530	NN	denotes	Txnrd1
T8593	26530-26531	-RRB-	denotes	)
T8594	26531-26533	,	denotes	,
T8595	26533-26536	CD	denotes	one
T8596	26537-26539	IN	denotes	of
T8597	26540-26543	DT	denotes	the
T8598	26553-26560	NNS	denotes	enzymes
T8599	26544-26552	VBG	denotes	reducing
T8600	26561-26563	IN	denotes	of
T8601	26564-26567	DT	denotes	the
T8602	26580-26591	NN	denotes	thioredoxin
T8603	26568-26579	NN	denotes	antioxidant
T8604	26592-26593	-LRB-	denotes	(
T8605	26593-26595	CD	denotes	46
T8606	26595-26596	-RRB-	denotes	)
T8607	26596-26597	:	denotes	;
T8608	26598-26602	NN	denotes	KDEL
T8609	26643-26651	NN	denotes	receptor
T8610	26603-26614	JJ	denotes	endoplasmic
T8611	26615-26624	NN	denotes	reticulum
T8612	26625-26632	NN	denotes	protein
T8613	26633-26642	NN	denotes	retention
T8614	26652-26653	CD	denotes	2
T8615	26654-26655	-LRB-	denotes	(
T8616	26655-26661	NN	denotes	Kdelr2
T8617	26661-26662	-RRB-	denotes	)
T8618	26663-26676	VBG	denotes	participating
T8619	26677-26679	IN	denotes	in
T8620	26680-26682	NN	denotes	ER
T8621	26690-26698	NN	denotes	response
T8622	26683-26689	NN	denotes	stress
T8623	26699-26700	-LRB-	denotes	(
T8624	26700-26702	CD	denotes	47
T8625	26702-26703	-RRB-	denotes	)
T8626	26703-26704	:	denotes	;
T8627	26705-26708	CC	denotes	and
T8628	26709-26712	DT	denotes	the
T8629	26744-26754	NN	denotes	athanogene
T8630	26713-26727	JJ	denotes	anti-apoptotic
T8631	26728-26732	NN	denotes	Bcl2
T8632	26732-26733	HYPH	denotes	-
T8633	26733-26743	VBN	denotes	associated
T8634	26755-26756	CD	denotes	3
T8635	26757-26758	-LRB-	denotes	(
T8636	26758-26762	NN	denotes	Bag3
T8637	26762-26763	-RRB-	denotes	)
T8638	26764-26772	VBN	denotes	involved
T8639	26773-26775	IN	denotes	in
T8640	26776-26782	NN	denotes	stress
T8641	26783-26790	VBN	denotes	induced
T8642	26782-26783	HYPH	denotes	-
T8643	26791-26800	NN	denotes	apoptosis
T8644	26801-26802	-LRB-	denotes	(
T8645	26802-26804	CD	denotes	48
T8646	26804-26805	-RRB-	denotes	)
T8647	26805-26806	.	denotes	.
T9786	26819-26821	IN	denotes	In
T9787	26944-26950	VB	denotes	affect
T9788	26822-26826	DT	denotes	this
T9789	26827-26832	NN	denotes	study
T9790	26832-26834	,	denotes	,
T9791	26834-26835	DT	denotes	a
T9792	26855-26863	NN	denotes	deletion
T9793	26836-26845	RB	denotes	virtually
T9794	26846-26854	JJ	denotes	complete
T9795	26864-26866	IN	denotes	of
T9796	26867-26871	NN	denotes	Mtf1
T9797	26872-26874	IN	denotes	in
T9798	26875-26878	DT	denotes	the
T9799	26879-26884	NN	denotes	liver
T9800	26885-26887	IN	denotes	of
T9801	26888-26893	JJ	denotes	adult
T9802	26920-26924	NNS	denotes	mice
T9803	26893-26895	,	denotes	,
T9804	26895-26897	NN	denotes	pI
T9805	26898-26900	NN	denotes	pC
T9806	26897-26898	HYPH	denotes	–
T9807	26901-26908	VBN	denotes	induced
T9808	26900-26901	HYPH	denotes	-
T9809	26909-26915	NN	denotes	Mtf1Mx
T9810	26916-26919	NN	denotes	cre
T9811	26915-26916	HYPH	denotes	-
T9812	26925-26928	VBD	denotes	did
T9813	26929-26932	RB	denotes	not
T9814	26933-26943	RB	denotes	detectably
T9815	26951-26954	DT	denotes	the
T9816	26955-26964	NN	denotes	phenotype
T9817	26965-26967	IN	denotes	of
T9818	26968-26971	DT	denotes	the
T9819	26983-26987	NNS	denotes	mice
T9820	26972-26982	JJ	denotes	respective
T9821	26988-26993	IN	denotes	under
T9822	26994-27004	JJ	denotes	non-stress
T9823	27005-27015	NNS	denotes	conditions
T9824	27015-27017	,	denotes	,
T9825	27017-27027	VBG	denotes	confirming
T9826	27028-27032	IN	denotes	that
T9827	27039-27041	VBZ	denotes	is
T9828	27033-27036	NN	denotes	MTF
T9829	27036-27037	HYPH	denotes	-
T9830	27037-27038	CD	denotes	1
T9831	27042-27053	JJ	denotes	dispensable
T9832	27054-27056	IN	denotes	in
T9833	27057-27060	DT	denotes	the
T9834	27067-27072	NN	denotes	liver
T9835	27061-27066	JJ	denotes	adult
T9836	27073-27074	-LRB-	denotes	(
T9837	27074-27076	CD	denotes	26
T9838	27076-27077	-RRB-	denotes	)
T9839	27077-27079	,	denotes	,
T9840	27079-27081	IN	denotes	in
T9841	27082-27090	NN	denotes	contrast
T9842	27091-27093	IN	denotes	to
T9843	27094-27097	PRP$	denotes	its
T9844	27108-27112	NN	denotes	role
T9845	27098-27107	JJ	denotes	essential
T9846	27113-27115	IN	denotes	in
T9847	27116-27125	JJ	denotes	embryonic
T9848	27132-27143	NN	denotes	development
T9849	27126-27131	NN	denotes	liver
T9850	27144-27145	-LRB-	denotes	(
T9851	27145-27147	CD	denotes	23
T9852	27147-27148	-RRB-	denotes	)
T9853	27148-27149	.	denotes	.
T9854	27149-27297	sentence	denotes	The comparison of gene expression in livers of mock- or cadmium-treated Mtf1Mx-cre and Mtf1loxP mice revealed several MTF-1 target gene candidates.
T9855	27150-27153	DT	denotes	The
T9856	27154-27164	NN	denotes	comparison
T9857	27251-27259	VBD	denotes	revealed
T9858	27165-27167	IN	denotes	of
T9859	27168-27172	NN	denotes	gene
T9860	27173-27183	NN	denotes	expression
T9861	27184-27186	IN	denotes	in
T9862	27187-27193	NNS	denotes	livers
T9863	27194-27196	IN	denotes	of
T9864	27197-27201	JJ	denotes	mock
T9865	27214-27221	VBN	denotes	treated
T9866	27201-27202	HYPH	denotes	-
T9867	27203-27205	CC	denotes	or
T9868	27206-27213	NN	denotes	cadmium
T9869	27213-27214	HYPH	denotes	-
T9870	27246-27250	NNS	denotes	mice
T9871	27222-27228	NN	denotes	Mtf1Mx
T9872	27229-27232	NN	denotes	cre
T9873	27228-27229	HYPH	denotes	-
T9874	27233-27236	CC	denotes	and
T9875	27237-27245	NN	denotes	Mtf1loxP
T9876	27260-27267	JJ	denotes	several
T9877	27286-27296	NNS	denotes	candidates
T9878	27268-27271	NN	denotes	MTF
T9879	27271-27272	HYPH	denotes	-
T9880	27272-27273	CD	denotes	1
T9881	27274-27280	NN	denotes	target
T9882	27281-27285	NN	denotes	gene
T9883	27296-27297	.	denotes	.
T9884	27297-27504	sentence	denotes	Transcripts of the two stress-responsive metallothionein genes Mt1 and Mt2 were severely reduced, in support of a crucial role of MTF-1 for both basal and metal-induced expression of metallothioneins (4,6).
T9885	27298-27309	NNS	denotes	Transcripts
T9886	27387-27394	VBN	denotes	reduced
T9887	27310-27312	IN	denotes	of
T9888	27313-27316	DT	denotes	the
T9889	27355-27360	NNS	denotes	genes
T9890	27317-27320	CD	denotes	two
T9891	27321-27327	NN	denotes	stress
T9892	27328-27338	JJ	denotes	responsive
T9893	27327-27328	HYPH	denotes	-
T9894	27339-27354	NN	denotes	metallothionein
T9895	27361-27364	NN	denotes	Mt1
T9896	27365-27368	CC	denotes	and
T9897	27369-27372	NN	denotes	Mt2
T9898	27373-27377	VBD	denotes	were
T9899	27378-27386	RB	denotes	severely
T9900	27394-27396	,	denotes	,
T9901	27396-27398	IN	denotes	in
T9902	27399-27406	NN	denotes	support
T9903	27407-27409	IN	denotes	of
T9904	27410-27411	DT	denotes	a
T9905	27420-27424	NN	denotes	role
T9906	27412-27419	JJ	denotes	crucial
T9907	27425-27427	IN	denotes	of
T9908	27428-27431	NN	denotes	MTF
T9909	27431-27432	HYPH	denotes	-
T9910	27432-27433	CD	denotes	1
T9911	27434-27437	IN	denotes	for
T9912	27438-27442	CC	denotes	both
T9913	27467-27477	NN	denotes	expression
T9914	27443-27448	JJ	denotes	basal
T9915	27449-27452	CC	denotes	and
T9916	27453-27458	NN	denotes	metal
T9917	27459-27466	VBN	denotes	induced
T9918	27458-27459	HYPH	denotes	-
T9919	27478-27480	IN	denotes	of
T9920	27481-27497	NNS	denotes	metallothioneins
T9921	27498-27499	-LRB-	denotes	(
T9922	27501-27502	CD	denotes	6
T9923	27499-27500	CD	denotes	4
T9924	27500-27501	,	denotes	,
T9925	27502-27503	-RRB-	denotes	)
T9926	27503-27504	.	denotes	.
T9927	27504-27550	sentence	denotes	One of the newly found target genes is Sepw1.
T9928	27505-27508	CD	denotes	One
T9929	27541-27543	VBZ	denotes	is
T9930	27509-27511	IN	denotes	of
T9931	27512-27515	DT	denotes	the
T9932	27535-27540	NNS	denotes	genes
T9933	27516-27521	RB	denotes	newly
T9934	27522-27527	VBN	denotes	found
T9935	27528-27534	NN	denotes	target
T9936	27544-27549	NN	denotes	Sepw1
T9937	27549-27550	.	denotes	.
T9938	27550-27705	sentence	denotes	The exact molecular function of SEPW1 protein is unknown to date, but a role as antioxidant has been proposed due to its ability to bind glutathione (35).
T9939	27551-27554	DT	denotes	The
T9940	27571-27579	NN	denotes	function
T9941	27555-27560	JJ	denotes	exact
T9942	27561-27570	JJ	denotes	molecular
T9943	27597-27599	VBZ	denotes	is
T9944	27580-27582	IN	denotes	of
T9945	27583-27588	NN	denotes	SEPW1
T9946	27589-27596	NN	denotes	protein
T9947	27600-27607	JJ	denotes	unknown
T9948	27608-27610	IN	denotes	to
T9949	27611-27615	NN	denotes	date
T9950	27615-27617	,	denotes	,
T9951	27617-27620	CC	denotes	but
T9952	27621-27622	DT	denotes	a
T9953	27623-27627	NN	denotes	role
T9954	27652-27660	VBN	denotes	proposed
T9955	27628-27630	IN	denotes	as
T9956	27631-27642	NN	denotes	antioxidant
T9957	27643-27646	VBZ	denotes	has
T9958	27647-27651	VBN	denotes	been
T9959	27661-27664	IN	denotes	due
T9960	27665-27667	IN	denotes	to
T9961	27668-27671	PRP$	denotes	its
T9962	27672-27679	NN	denotes	ability
T9963	27680-27682	TO	denotes	to
T9964	27683-27687	VB	denotes	bind
T9965	27688-27699	NN	denotes	glutathione
T9966	27700-27701	-LRB-	denotes	(
T9967	27701-27703	CD	denotes	35
T9968	27703-27704	-RRB-	denotes	)
T9969	27704-27705	.	denotes	.
T9970	27705-27875	sentence	denotes	In accordance with this, ectopic expression of mouse Sepw1 renders cells resistant to hydrogen peroxide, and this resistance is dependent on it binding glutathione (36).
T9971	27706-27708	IN	denotes	In
T9972	27765-27772	VBZ	denotes	renders
T9973	27709-27719	NN	denotes	accordance
T9974	27720-27724	IN	denotes	with
T9975	27725-27729	DT	denotes	this
T9976	27729-27731	,	denotes	,
T9977	27731-27738	JJ	denotes	ectopic
T9978	27739-27749	NN	denotes	expression
T9979	27750-27752	IN	denotes	of
T9980	27753-27758	NN	denotes	mouse
T9981	27759-27764	NN	denotes	Sepw1
T9982	27773-27778	NNS	denotes	cells
T9983	27779-27788	JJ	denotes	resistant
T9984	27789-27791	IN	denotes	to
T9985	27792-27800	NN	denotes	hydrogen
T9986	27801-27809	NN	denotes	peroxide
T9987	27809-27811	,	denotes	,
T9988	27811-27814	CC	denotes	and
T9989	27815-27819	DT	denotes	this
T9990	27820-27830	NN	denotes	resistance
T9991	27831-27833	VBZ	denotes	is
T9992	27834-27843	JJ	denotes	dependent
T9993	27844-27846	IN	denotes	on
T9994	27847-27849	PRP	denotes	it
T9995	27858-27869	NN	denotes	glutathione
T9996	27850-27857	VBG	denotes	binding
T9997	27870-27871	-LRB-	denotes	(
T9998	27871-27873	CD	denotes	36
T9999	27873-27874	-RRB-	denotes	)
T10000	27874-27875	.	denotes	.
T10001	27875-28061	sentence	denotes	Furthermore, Amantana et al. (49) showed that expression of a reporter gene fused to a rat Sepw1 promoter fragment can be induced in rat glial cells by copper and zinc, but not cadmium.
T10002	27876-27887	RB	denotes	Furthermore
T10003	27910-27916	VBD	denotes	showed
T10004	27887-27889	,	denotes	,
T10005	27889-27897	NNP	denotes	Amantana
T10006	27898-27900	FW	denotes	et
T10007	27901-27904	FW	denotes	al.
T10008	27905-27906	-LRB-	denotes	(
T10009	27906-27908	CD	denotes	49
T10010	27908-27909	-RRB-	denotes	)
T10011	27917-27921	IN	denotes	that
T10012	27998-28005	VBN	denotes	induced
T10013	27922-27932	NN	denotes	expression
T10014	27933-27935	IN	denotes	of
T10015	27936-27937	DT	denotes	a
T10016	27947-27951	NN	denotes	gene
T10017	27938-27946	NN	denotes	reporter
T10018	27952-27957	VBN	denotes	fused
T10019	27958-27960	IN	denotes	to
T10020	27961-27962	DT	denotes	a
T10021	27982-27990	NN	denotes	fragment
T10022	27963-27966	NN	denotes	rat
T10023	27967-27972	NN	denotes	Sepw1
T10024	27973-27981	NN	denotes	promoter
T10025	27991-27994	MD	denotes	can
T10026	27995-27997	VB	denotes	be
T10027	28006-28008	IN	denotes	in
T10028	28009-28012	NN	denotes	rat
T10029	28019-28024	NNS	denotes	cells
T10030	28013-28018	JJ	denotes	glial
T10031	28025-28027	IN	denotes	by
T10032	28028-28034	NN	denotes	copper
T10033	28035-28038	CC	denotes	and
T10034	28039-28043	NN	denotes	zinc
T10035	28043-28045	,	denotes	,
T10036	28045-28048	CC	denotes	but
T10037	28049-28052	RB	denotes	not
T10038	28053-28060	NN	denotes	cadmium
T10039	28060-28061	.	denotes	.
T10040	28061-28276	sentence	denotes	This response was dependent on an overlapping-inverted MRE sequence located proximal to the rat Sepw1 transcription start (49), even though initial studies failed to demonstrate MTF-1 binding to that sequence (50).
T10041	28062-28066	DT	denotes	This
T10042	28067-28075	NN	denotes	response
T10043	28076-28079	VBD	denotes	was
T10044	28080-28089	JJ	denotes	dependent
T10045	28090-28092	IN	denotes	on
T10046	28093-28095	DT	denotes	an
T10047	28121-28129	NN	denotes	sequence
T10048	28096-28107	JJ	denotes	overlapping
T10049	28108-28116	JJ	denotes	inverted
T10050	28107-28108	HYPH	denotes	-
T10051	28117-28120	NN	denotes	MRE
T10052	28130-28137	VBN	denotes	located
T10053	28138-28146	RB	denotes	proximal
T10054	28147-28149	IN	denotes	to
T10055	28150-28153	DT	denotes	the
T10056	28178-28183	NN	denotes	start
T10057	28154-28157	NN	denotes	rat
T10058	28158-28163	NN	denotes	Sepw1
T10059	28164-28177	NN	denotes	transcription
T10060	28184-28185	-LRB-	denotes	(
T10061	28185-28187	CD	denotes	49
T10062	28187-28188	-RRB-	denotes	)
T10063	28188-28190	,	denotes	,
T10064	28190-28194	RB	denotes	even
T10065	28218-28224	VBD	denotes	failed
T10066	28195-28201	IN	denotes	though
T10067	28202-28209	JJ	denotes	initial
T10068	28210-28217	NNS	denotes	studies
T10069	28225-28227	TO	denotes	to
T10070	28228-28239	VB	denotes	demonstrate
T10071	28240-28243	NN	denotes	MTF
T10072	28246-28253	NN	denotes	binding
T10073	28243-28244	HYPH	denotes	-
T10074	28244-28245	CD	denotes	1
T10075	28254-28256	IN	denotes	to
T10076	28257-28261	DT	denotes	that
T10077	28262-28270	NN	denotes	sequence
T10078	28271-28272	-LRB-	denotes	(
T10079	28272-28274	CD	denotes	50
T10080	28274-28275	-RRB-	denotes	)
T10081	28275-28276	.	denotes	.
T10082	28276-28463	sentence	denotes	Our expression and DNA-binding studies strongly suggest that MTF-1 is important for the basal expression of mouse Sepw1 by binding to the corresponding overlapping-inverted MRE sequence.
T10083	28277-28280	PRP$	denotes	Our
T10084	28281-28291	NN	denotes	expression
T10085	28325-28332	VBP	denotes	suggest
T10086	28292-28295	CC	denotes	and
T10087	28296-28299	NN	denotes	DNA
T10088	28300-28307	VBG	denotes	binding
T10089	28299-28300	HYPH	denotes	-
T10090	28308-28315	NNS	denotes	studies
T10091	28316-28324	RB	denotes	strongly
T10092	28333-28337	IN	denotes	that
T10093	28344-28346	VBZ	denotes	is
T10094	28338-28341	NN	denotes	MTF
T10095	28341-28342	HYPH	denotes	-
T10096	28342-28343	CD	denotes	1
T10097	28347-28356	JJ	denotes	important
T10098	28357-28360	IN	denotes	for
T10099	28361-28364	DT	denotes	the
T10100	28371-28381	NN	denotes	expression
T10101	28365-28370	JJ	denotes	basal
T10102	28382-28384	IN	denotes	of
T10103	28385-28390	NN	denotes	mouse
T10104	28391-28396	NN	denotes	Sepw1
T10105	28397-28399	IN	denotes	by
T10106	28400-28407	VBG	denotes	binding
T10107	28408-28410	IN	denotes	to
T10108	28411-28414	DT	denotes	the
T10109	28454-28462	NN	denotes	sequence
T10110	28415-28428	VBG	denotes	corresponding
T10111	28429-28440	JJ	denotes	overlapping
T10112	28441-28449	JJ	denotes	inverted
T10113	28440-28441	HYPH	denotes	-
T10114	28450-28453	NN	denotes	MRE
T10115	28462-28463	.	denotes	.
T10116	28463-28658	sentence	denotes	Ndrg1, another interesting MTF-1 target gene was named N-myc downstream regulated gene 1 following the discovery that the transcription factor N-myc represses the expression of mouse Ndrg1 (51).
T10117	28464-28469	NN	denotes	Ndrg1
T10118	28513-28518	VBN	denotes	named
T10119	28469-28471	,	denotes	,
T10120	28471-28478	DT	denotes	another
T10121	28504-28508	NN	denotes	gene
T10122	28479-28490	JJ	denotes	interesting
T10123	28491-28494	NN	denotes	MTF
T10124	28494-28495	HYPH	denotes	-
T10125	28495-28496	CD	denotes	1
T10126	28497-28503	NN	denotes	target
T10127	28509-28512	VBD	denotes	was
T10128	28519-28520	NN	denotes	N
T10129	28521-28524	NN	denotes	myc
T10130	28520-28521	HYPH	denotes	-
T10131	28546-28550	NN	denotes	gene
T10132	28525-28535	RB	denotes	downstream
T10133	28536-28545	VBN	denotes	regulated
T10134	28551-28552	CD	denotes	1
T10135	28553-28562	VBG	denotes	following
T10136	28563-28566	DT	denotes	the
T10137	28567-28576	NN	denotes	discovery
T10138	28577-28581	IN	denotes	that
T10139	28613-28622	VBZ	denotes	represses
T10140	28582-28585	DT	denotes	the
T10141	28600-28606	NN	denotes	factor
T10142	28586-28599	NN	denotes	transcription
T10143	28607-28608	NN	denotes	N
T10144	28609-28612	NN	denotes	myc
T10145	28608-28609	HYPH	denotes	-
T10146	28623-28626	DT	denotes	the
T10147	28627-28637	NN	denotes	expression
T10148	28638-28640	IN	denotes	of
T10149	28641-28646	NN	denotes	mouse
T10150	28647-28652	NN	denotes	Ndrg1
T10151	28653-28654	-LRB-	denotes	(
T10152	28654-28656	CD	denotes	51
T10153	28656-28657	-RRB-	denotes	)
T10154	28657-28658	.	denotes	.
T10155	28658-28848	sentence	denotes	Transcription of Ndrg1 and/or its human ortholog is induced by different physiological and cell stress conditions, such as androgens, nickel compounds, DNA damage and hypoxia (37–40,52,53).
T10156	28659-28672	NN	denotes	Transcription
T10157	28711-28718	VBN	denotes	induced
T10158	28673-28675	IN	denotes	of
T10159	28676-28681	NN	denotes	Ndrg1
T10160	28682-28685	CC	denotes	and
T10161	28685-28686	HYPH	denotes	/
T10162	28686-28688	CC	denotes	or
T10163	28689-28692	PRP$	denotes	its
T10164	28699-28707	NN	denotes	ortholog
T10165	28693-28698	JJ	denotes	human
T10166	28708-28710	VBZ	denotes	is
T10167	28719-28721	IN	denotes	by
T10168	28722-28731	JJ	denotes	different
T10169	28762-28772	NNS	denotes	conditions
T10170	28732-28745	JJ	denotes	physiological
T10171	28746-28749	CC	denotes	and
T10172	28750-28754	NN	denotes	cell
T10173	28755-28761	NN	denotes	stress
T10174	28772-28774	,	denotes	,
T10175	28774-28778	JJ	denotes	such
T10176	28779-28781	IN	denotes	as
T10177	28782-28791	NNS	denotes	androgens
T10178	28791-28793	,	denotes	,
T10179	28793-28799	NN	denotes	nickel
T10180	28800-28809	NNS	denotes	compounds
T10181	28809-28811	,	denotes	,
T10182	28811-28814	NN	denotes	DNA
T10183	28815-28821	NN	denotes	damage
T10184	28822-28825	CC	denotes	and
T10185	28826-28833	NN	denotes	hypoxia
T10186	28834-28835	-LRB-	denotes	(
T10187	28844-28846	CD	denotes	53
T10188	28835-28837	CD	denotes	37
T10189	28837-28838	SYM	denotes	–
T10190	28838-28840	CD	denotes	40
T10191	28840-28841	,	denotes	,
T10192	28841-28843	CD	denotes	52
T10193	28843-28844	,	denotes	,
T10194	28846-28847	-RRB-	denotes	)
T10195	28847-28848	.	denotes	.
T10196	28848-28982	sentence	denotes	In addition, the protein is overexpressed in human cancers of many tissues, such as lung, liver, brain, breast, kidney and skin (40).
T10197	28849-28851	IN	denotes	In
T10198	28877-28890	VBN	denotes	overexpressed
T10199	28852-28860	NN	denotes	addition
T10200	28860-28862	,	denotes	,
T10201	28862-28865	DT	denotes	the
T10202	28866-28873	NN	denotes	protein
T10203	28874-28876	VBZ	denotes	is
T10204	28891-28893	IN	denotes	in
T10205	28894-28899	JJ	denotes	human
T10206	28900-28907	NNS	denotes	cancers
T10207	28908-28910	IN	denotes	of
T10208	28911-28915	JJ	denotes	many
T10209	28916-28923	NNS	denotes	tissues
T10210	28923-28925	,	denotes	,
T10211	28925-28929	JJ	denotes	such
T10212	28930-28932	IN	denotes	as
T10213	28933-28937	NN	denotes	lung
T10214	28937-28939	,	denotes	,
T10215	28939-28944	NN	denotes	liver
T10216	28944-28946	,	denotes	,
T10217	28946-28951	NN	denotes	brain
T10218	28951-28953	,	denotes	,
T10219	28953-28959	NN	denotes	breast
T10220	28959-28961	,	denotes	,
T10221	28961-28967	NN	denotes	kidney
T10222	28968-28971	CC	denotes	and
T10223	28972-28976	NN	denotes	skin
T10224	28977-28978	-LRB-	denotes	(
T10225	28978-28980	CD	denotes	40
T10226	28980-28981	-RRB-	denotes	)
T10227	28981-28982	.	denotes	.
T10228	28982-29207	sentence	denotes	Although Ndrg1 and especially its human ortholog have been quite intensely studied, its function remains unclear; however, the induction by stimuli like nickel and hypoxia suggests an involvement in the cell stress response.
T10229	28983-28991	IN	denotes	Although
T10230	29058-29065	VBN	denotes	studied
T10231	28992-28997	NN	denotes	Ndrg1
T10232	28998-29001	CC	denotes	and
T10233	29002-29012	RB	denotes	especially
T10234	29023-29031	NN	denotes	ortholog
T10235	29013-29016	PRP$	denotes	its
T10236	29017-29022	JJ	denotes	human
T10237	29032-29036	VBP	denotes	have
T10238	29037-29041	VBN	denotes	been
T10239	29042-29047	RB	denotes	quite
T10240	29048-29057	RB	denotes	intensely
T10241	29080-29087	VBZ	denotes	remains
T10242	29065-29067	,	denotes	,
T10243	29067-29070	PRP$	denotes	its
T10244	29071-29079	NN	denotes	function
T10245	29155-29163	VBZ	denotes	suggests
T10246	29088-29095	JJ	denotes	unclear
T10247	29095-29096	:	denotes	;
T10248	29097-29104	RB	denotes	however
T10249	29104-29106	,	denotes	,
T10250	29106-29109	DT	denotes	the
T10251	29110-29119	NN	denotes	induction
T10252	29120-29122	IN	denotes	by
T10253	29123-29130	NNS	denotes	stimuli
T10254	29131-29135	IN	denotes	like
T10255	29136-29142	NN	denotes	nickel
T10256	29143-29146	CC	denotes	and
T10257	29147-29154	NN	denotes	hypoxia
T10258	29164-29166	DT	denotes	an
T10259	29167-29178	NN	denotes	involvement
T10260	29179-29181	IN	denotes	in
T10261	29182-29185	DT	denotes	the
T10262	29198-29206	NN	denotes	response
T10263	29186-29190	NN	denotes	cell
T10264	29191-29197	NN	denotes	stress
T10265	29206-29207	.	denotes	.
T10266	29207-29365	sentence	denotes	Such a role is strongly endorsed by our finding that Ndrg1 gene expression is also induced by cadmium, and that MTF-1 plays a crucial role in this induction.
T10267	29208-29212	PDT	denotes	Such
T10268	29215-29219	NN	denotes	role
T10269	29213-29214	DT	denotes	a
T10270	29232-29240	VBN	denotes	endorsed
T10271	29220-29222	VBZ	denotes	is
T10272	29223-29231	RB	denotes	strongly
T10273	29241-29243	IN	denotes	by
T10274	29244-29247	PRP$	denotes	our
T10275	29248-29255	NN	denotes	finding
T10276	29256-29260	IN	denotes	that
T10277	29291-29298	VBN	denotes	induced
T10278	29261-29266	NN	denotes	Ndrg1
T10279	29272-29282	NN	denotes	expression
T10280	29267-29271	NN	denotes	gene
T10281	29283-29285	VBZ	denotes	is
T10282	29286-29290	RB	denotes	also
T10283	29299-29301	IN	denotes	by
T10284	29302-29309	NN	denotes	cadmium
T10285	29309-29311	,	denotes	,
T10286	29311-29314	CC	denotes	and
T10287	29315-29319	IN	denotes	that
T10288	29326-29331	VBZ	denotes	plays
T10289	29320-29323	NN	denotes	MTF
T10290	29323-29324	HYPH	denotes	-
T10291	29324-29325	CD	denotes	1
T10292	29332-29333	DT	denotes	a
T10293	29342-29346	NN	denotes	role
T10294	29334-29341	JJ	denotes	crucial
T10295	29347-29349	IN	denotes	in
T10296	29350-29354	DT	denotes	this
T10297	29355-29364	NN	denotes	induction
T10298	29364-29365	.	denotes	.
T10299	29365-29543	sentence	denotes	In the case of Csrp1, expression analyses and DNA-binding studies indicate that MTF-1 is required for cadmium induction by binding to an MRE upstream of the transcription start.
T10300	29366-29368	IN	denotes	In
T10301	29432-29440	VBP	denotes	indicate
T10302	29369-29372	DT	denotes	the
T10303	29373-29377	NN	denotes	case
T10304	29378-29380	IN	denotes	of
T10305	29381-29386	NN	denotes	Csrp1
T10306	29386-29388	,	denotes	,
T10307	29388-29398	NN	denotes	expression
T10308	29399-29407	NNS	denotes	analyses
T10309	29424-29431	NNS	denotes	studies
T10310	29408-29411	CC	denotes	and
T10311	29412-29415	NN	denotes	DNA
T10312	29415-29416	HYPH	denotes	-
T10313	29416-29423	VBG	denotes	binding
T10314	29441-29445	IN	denotes	that
T10315	29455-29463	VBN	denotes	required
T10316	29446-29449	NN	denotes	MTF
T10317	29449-29450	HYPH	denotes	-
T10318	29450-29451	CD	denotes	1
T10319	29452-29454	VBZ	denotes	is
T10320	29464-29467	IN	denotes	for
T10321	29468-29475	NN	denotes	cadmium
T10322	29476-29485	NN	denotes	induction
T10323	29486-29488	IN	denotes	by
T10324	29489-29496	VBG	denotes	binding
T10325	29497-29499	IN	denotes	to
T10326	29500-29502	DT	denotes	an
T10327	29503-29506	NN	denotes	MRE
T10328	29507-29515	RB	denotes	upstream
T10329	29516-29518	IN	denotes	of
T10330	29519-29522	DT	denotes	the
T10331	29537-29542	NN	denotes	start
T10332	29523-29536	NN	denotes	transcription
T10333	29542-29543	.	denotes	.
T10334	29543-29812	sentence	denotes	Studies with human, avian and chicken CSRP1 have shown that this protein is localized at adhesion plaques and in association with filamentous actin, and interacts with the adhesion plaque protein zyxin, as well as the actin-cross-linking protein alpha-actinin (54–57).
T10335	29544-29551	NNS	denotes	Studies
T10336	29593-29598	VBN	denotes	shown
T10337	29552-29556	IN	denotes	with
T10338	29557-29562	JJ	denotes	human
T10339	29582-29587	NN	denotes	CSRP1
T10340	29562-29564	,	denotes	,
T10341	29564-29569	JJ	denotes	avian
T10342	29570-29573	CC	denotes	and
T10343	29574-29581	NN	denotes	chicken
T10344	29588-29592	VBP	denotes	have
T10345	29599-29603	IN	denotes	that
T10346	29620-29629	VBN	denotes	localized
T10347	29604-29608	DT	denotes	this
T10348	29609-29616	NN	denotes	protein
T10349	29617-29619	VBZ	denotes	is
T10350	29630-29632	IN	denotes	at
T10351	29633-29641	NN	denotes	adhesion
T10352	29642-29649	NNS	denotes	plaques
T10353	29650-29653	CC	denotes	and
T10354	29654-29656	IN	denotes	in
T10355	29657-29668	NN	denotes	association
T10356	29669-29673	IN	denotes	with
T10357	29674-29685	JJ	denotes	filamentous
T10358	29686-29691	NN	denotes	actin
T10359	29691-29693	,	denotes	,
T10360	29693-29696	CC	denotes	and
T10361	29697-29706	VBZ	denotes	interacts
T10362	29707-29711	IN	denotes	with
T10363	29712-29715	DT	denotes	the
T10364	29732-29739	NN	denotes	protein
T10365	29716-29724	NN	denotes	adhesion
T10366	29725-29731	NN	denotes	plaque
T10367	29740-29745	NN	denotes	zyxin
T10368	29745-29747	,	denotes	,
T10369	29747-29749	RB	denotes	as
T10370	29755-29757	IN	denotes	as
T10371	29750-29754	RB	denotes	well
T10372	29758-29761	DT	denotes	the
T10373	29782-29789	NN	denotes	protein
T10374	29762-29767	NN	denotes	actin
T10375	29768-29781	VBG	denotes	cross-linking
T10376	29767-29768	HYPH	denotes	-
T10377	29790-29795	NN	denotes	alpha
T10378	29796-29803	NN	denotes	actinin
T10379	29795-29796	HYPH	denotes	-
T10380	29804-29805	-LRB-	denotes	(
T10381	29805-29807	CD	denotes	54
T10382	29807-29808	SYM	denotes	–
T10383	29808-29810	CD	denotes	57
T10384	29810-29811	-RRB-	denotes	)
T10385	29811-29812	.	denotes	.
T10386	29812-29898	sentence	denotes	The ability to bind these partners suggests a role in cytoskeletal organization (58).
T10387	29813-29816	DT	denotes	The
T10388	29817-29824	NN	denotes	ability
T10389	29848-29856	VBZ	denotes	suggests
T10390	29825-29827	TO	denotes	to
T10391	29828-29832	VB	denotes	bind
T10392	29833-29838	DT	denotes	these
T10393	29839-29847	NNS	denotes	partners
T10394	29857-29858	DT	denotes	a
T10395	29859-29863	NN	denotes	role
T10396	29864-29866	IN	denotes	in
T10397	29867-29879	JJ	denotes	cytoskeletal
T10398	29880-29892	NN	denotes	organization
T10399	29893-29894	-LRB-	denotes	(
T10400	29894-29896	CD	denotes	58
T10401	29896-29897	-RRB-	denotes	)
T10402	29897-29898	.	denotes	.
T10403	29898-30037	sentence	denotes	Exposure of cultured cells to cadmium causes a decrease in, and destruction of, cellular contact proteins and the actin cytoskeleton (59).
T10404	29899-29907	NN	denotes	Exposure
T10405	29937-29943	VBZ	denotes	causes
T10406	29908-29910	IN	denotes	of
T10407	29911-29919	VBN	denotes	cultured
T10408	29920-29925	NNS	denotes	cells
T10409	29926-29928	IN	denotes	to
T10410	29929-29936	NN	denotes	cadmium
T10411	29944-29945	DT	denotes	a
T10412	29946-29954	NN	denotes	decrease
T10413	29955-29957	IN	denotes	in
T10414	29957-29959	,	denotes	,
T10415	29959-29962	CC	denotes	and
T10416	29963-29974	NN	denotes	destruction
T10417	29975-29977	IN	denotes	of
T10418	29977-29979	,	denotes	,
T10419	29979-29987	JJ	denotes	cellular
T10420	29988-29995	NN	denotes	contact
T10421	29996-30004	NN	denotes	proteins
T10422	30005-30008	CC	denotes	and
T10423	30009-30012	DT	denotes	the
T10424	30019-30031	NN	denotes	cytoskeleton
T10425	30013-30018	NN	denotes	actin
T10426	30032-30033	-LRB-	denotes	(
T10427	30033-30035	CD	denotes	59
T10428	30035-30036	-RRB-	denotes	)
T10429	30036-30037	.	denotes	.
T10430	30037-30253	sentence	denotes	In the proximal tubule cells of the rat kidney, a partial loss of actin and the actin-bundling protein villin is observed upon cadmium treatment, as well as the derangement and depolymerization of microtubules (60).
T10431	30038-30040	IN	denotes	In
T10432	30151-30159	VBN	denotes	observed
T10433	30041-30044	DT	denotes	the
T10434	30061-30066	NNS	denotes	cells
T10435	30045-30053	JJ	denotes	proximal
T10436	30054-30060	NN	denotes	tubule
T10437	30067-30069	IN	denotes	of
T10438	30070-30073	DT	denotes	the
T10439	30078-30084	NN	denotes	kidney
T10440	30074-30077	NN	denotes	rat
T10441	30084-30086	,	denotes	,
T10442	30086-30087	DT	denotes	a
T10443	30096-30100	NN	denotes	loss
T10444	30088-30095	JJ	denotes	partial
T10445	30101-30103	IN	denotes	of
T10446	30104-30109	NN	denotes	actin
T10447	30110-30113	CC	denotes	and
T10448	30114-30117	DT	denotes	the
T10449	30133-30140	NN	denotes	protein
T10450	30118-30123	NN	denotes	actin
T10451	30124-30132	VBG	denotes	bundling
T10452	30123-30124	HYPH	denotes	-
T10453	30141-30147	NN	denotes	villin
T10454	30148-30150	VBZ	denotes	is
T10455	30160-30164	IN	denotes	upon
T10456	30165-30172	NN	denotes	cadmium
T10457	30173-30182	NN	denotes	treatment
T10458	30182-30184	,	denotes	,
T10459	30184-30186	RB	denotes	as
T10460	30192-30194	IN	denotes	as
T10461	30187-30191	RB	denotes	well
T10462	30195-30198	DT	denotes	the
T10463	30199-30210	NN	denotes	derangement
T10464	30211-30214	CC	denotes	and
T10465	30215-30231	NN	denotes	depolymerization
T10466	30232-30234	IN	denotes	of
T10467	30235-30247	NNS	denotes	microtubules
T10468	30248-30249	-LRB-	denotes	(
T10469	30249-30251	CD	denotes	60
T10470	30251-30252	-RRB-	denotes	)
T10471	30252-30253	.	denotes	.
T10472	30253-30434	sentence	denotes	Assuming that CSRP1 is important for the organization of cytoskeletal elements in the mouse, its upregulation by cadmium might protect the organism from damage of the cytoskeleton.
T10473	30254-30262	VBG	denotes	Assuming
T10474	30381-30388	VB	denotes	protect
T10475	30263-30267	IN	denotes	that
T10476	30274-30276	VBZ	denotes	is
T10477	30268-30273	NN	denotes	CSRP1
T10478	30277-30286	JJ	denotes	important
T10479	30287-30290	IN	denotes	for
T10480	30291-30294	DT	denotes	the
T10481	30295-30307	NN	denotes	organization
T10482	30308-30310	IN	denotes	of
T10483	30311-30323	JJ	denotes	cytoskeletal
T10484	30324-30332	NNS	denotes	elements
T10485	30333-30335	IN	denotes	in
T10486	30336-30339	DT	denotes	the
T10487	30340-30345	NN	denotes	mouse
T10488	30345-30347	,	denotes	,
T10489	30347-30350	PRP$	denotes	its
T10490	30351-30363	NN	denotes	upregulation
T10491	30364-30366	IN	denotes	by
T10492	30367-30374	NN	denotes	cadmium
T10493	30375-30380	MD	denotes	might
T10494	30389-30392	DT	denotes	the
T10495	30393-30401	NN	denotes	organism
T10496	30402-30406	IN	denotes	from
T10497	30407-30413	NN	denotes	damage
T10498	30414-30416	IN	denotes	of
T10499	30417-30420	DT	denotes	the
T10500	30421-30433	NN	denotes	cytoskeleton
T10501	30433-30434	.	denotes	.
T10502	30434-30502	sentence	denotes	Such a mechanism would expand the role of MTF-1 in stress response.
T10503	30435-30439	PDT	denotes	Such
T10504	30442-30451	NN	denotes	mechanism
T10505	30440-30441	DT	denotes	a
T10506	30458-30464	VB	denotes	expand
T10507	30452-30457	MD	denotes	would
T10508	30465-30468	DT	denotes	the
T10509	30469-30473	NN	denotes	role
T10510	30474-30476	IN	denotes	of
T10511	30477-30480	NN	denotes	MTF
T10512	30480-30481	HYPH	denotes	-
T10513	30481-30482	CD	denotes	1
T10514	30483-30485	IN	denotes	in
T10515	30486-30492	NN	denotes	stress
T10516	30493-30501	NN	denotes	response
T10517	30501-30502	.	denotes	.
T10518	30502-30702	sentence	denotes	Our expression studies also suggest that MTF-1 represses basal transcription of Slc39a10, in contrast to its role as activator for the expression of other target genes like Mt1, Mt2, and Znt1 (4,19).
T10519	30503-30506	PRP$	denotes	Our
T10520	30518-30525	NNS	denotes	studies
T10521	30507-30517	NN	denotes	expression
T10522	30531-30538	VBP	denotes	suggest
T10523	30526-30530	RB	denotes	also
T10524	30539-30543	IN	denotes	that
T10525	30550-30559	VBZ	denotes	represses
T10526	30544-30547	NN	denotes	MTF
T10527	30547-30548	HYPH	denotes	-
T10528	30548-30549	CD	denotes	1
T10529	30560-30565	JJ	denotes	basal
T10530	30566-30579	NN	denotes	transcription
T10531	30580-30582	IN	denotes	of
T10532	30583-30591	NN	denotes	Slc39a10
T10533	30591-30593	,	denotes	,
T10534	30593-30595	IN	denotes	in
T10535	30596-30604	NN	denotes	contrast
T10536	30605-30607	IN	denotes	to
T10537	30608-30611	PRP$	denotes	its
T10538	30612-30616	NN	denotes	role
T10539	30617-30619	IN	denotes	as
T10540	30620-30629	NN	denotes	activator
T10541	30630-30633	IN	denotes	for
T10542	30634-30637	DT	denotes	the
T10543	30638-30648	NN	denotes	expression
T10544	30649-30651	IN	denotes	of
T10545	30652-30657	JJ	denotes	other
T10546	30665-30670	NNS	denotes	genes
T10547	30658-30664	NN	denotes	target
T10548	30671-30675	IN	denotes	like
T10549	30676-30679	NN	denotes	Mt1
T10550	30679-30681	,	denotes	,
T10551	30681-30684	NN	denotes	Mt2
T10552	30684-30686	,	denotes	,
T10553	30686-30689	CC	denotes	and
T10554	30690-30694	NN	denotes	Znt1
T10555	30695-30696	-LRB-	denotes	(
T10556	30698-30700	CD	denotes	19
T10557	30696-30697	CD	denotes	4
T10558	30697-30698	,	denotes	,
T10559	30700-30701	-RRB-	denotes	)
T10560	30701-30702	.	denotes	.
T10561	30702-30811	sentence	denotes	SLC39A10 is one of 14 mouse SLC39 members, which belong to the ZIP family of metal ion transporters (43,44).
T10562	30703-30711	NN	denotes	SLC39A10
T10563	30712-30714	VBZ	denotes	is
T10564	30715-30718	CD	denotes	one
T10565	30719-30721	IN	denotes	of
T10566	30722-30724	CD	denotes	14
T10567	30737-30744	NNS	denotes	members
T10568	30725-30730	NN	denotes	mouse
T10569	30731-30736	NN	denotes	SLC39
T10570	30744-30746	,	denotes	,
T10571	30746-30751	WDT	denotes	which
T10572	30752-30758	VBP	denotes	belong
T10573	30759-30761	IN	denotes	to
T10574	30762-30765	DT	denotes	the
T10575	30770-30776	NN	denotes	family
T10576	30766-30769	NN	denotes	ZIP
T10577	30777-30779	IN	denotes	of
T10578	30780-30785	NN	denotes	metal
T10579	30786-30789	NN	denotes	ion
T10580	30790-30802	NNS	denotes	transporters
T10581	30803-30804	-LRB-	denotes	(
T10582	30807-30809	CD	denotes	44
T10583	30804-30806	CD	denotes	43
T10584	30806-30807	,	denotes	,
T10585	30809-30810	-RRB-	denotes	)
T10586	30810-30811	.	denotes	.
T10587	30811-30997	sentence	denotes	All members of the ZIP family characterized so far increase intracellular cytoplasmic metal ion concentrations by promoting extracellular and vesicular ion transport into the cytoplasm.
T10588	30812-30815	DT	denotes	All
T10589	30816-30823	NNS	denotes	members
T10590	30863-30871	VBP	denotes	increase
T10591	30824-30826	IN	denotes	of
T10592	30827-30830	DT	denotes	the
T10593	30835-30841	NN	denotes	family
T10594	30831-30834	NN	denotes	ZIP
T10595	30842-30855	VBN	denotes	characterized
T10596	30856-30858	RB	denotes	so
T10597	30859-30862	RB	denotes	far
T10598	30872-30885	JJ	denotes	intracellular
T10599	30908-30922	NNS	denotes	concentrations
T10600	30886-30897	JJ	denotes	cytoplasmic
T10601	30898-30903	NN	denotes	metal
T10602	30904-30907	NN	denotes	ion
T10603	30923-30925	IN	denotes	by
T10604	30926-30935	VBG	denotes	promoting
T10605	30936-30949	JJ	denotes	extracellular
T10606	30968-30977	NN	denotes	transport
T10607	30950-30953	CC	denotes	and
T10608	30954-30963	JJ	denotes	vesicular
T10609	30964-30967	NN	denotes	ion
T10610	30978-30982	IN	denotes	into
T10611	30983-30986	DT	denotes	the
T10612	30987-30996	NN	denotes	cytoplasm
T10613	30996-30997	.	denotes	.
T10614	30997-31100	sentence	denotes	ZIP proteins have been reported to be transporters of zinc, iron, manganese and/or cadmium (44,61–63).
T10615	30998-31001	NN	denotes	ZIP
T10616	31002-31010	NN	denotes	proteins
T10617	31021-31029	VBN	denotes	reported
T10618	31011-31015	VBP	denotes	have
T10619	31016-31020	VBN	denotes	been
T10620	31030-31032	TO	denotes	to
T10621	31033-31035	VB	denotes	be
T10622	31036-31048	NNS	denotes	transporters
T10623	31049-31051	IN	denotes	of
T10624	31052-31056	NN	denotes	zinc
T10625	31056-31058	,	denotes	,
T10626	31058-31062	NN	denotes	iron
T10627	31062-31064	,	denotes	,
T10628	31064-31073	NN	denotes	manganese
T10629	31074-31077	CC	denotes	and
T10630	31077-31078	HYPH	denotes	/
T10631	31078-31080	CC	denotes	or
T10632	31081-31088	NN	denotes	cadmium
T10633	31089-31090	-LRB-	denotes	(
T10634	31090-31092	CD	denotes	44
T10635	31092-31093	,	denotes	,
T10636	31093-31095	CD	denotes	61
T10637	31095-31096	SYM	denotes	–
T10638	31096-31098	CD	denotes	63
T10639	31098-31099	-RRB-	denotes	)
T10640	31099-31100	.	denotes	.
T10641	31100-31220	sentence	denotes	Although SLC39A10 is largely uncharacterized (44), it is referred to in several databases as putative zinc transporter.
T10642	31101-31109	IN	denotes	Although
T10643	31119-31121	VBZ	denotes	is
T10644	31110-31118	NN	denotes	SLC39A10
T10645	31158-31166	VBN	denotes	referred
T10646	31122-31129	RB	denotes	largely
T10647	31130-31145	JJ	denotes	uncharacterized
T10648	31146-31147	-LRB-	denotes	(
T10649	31147-31149	CD	denotes	44
T10650	31149-31150	-RRB-	denotes	)
T10651	31150-31152	,	denotes	,
T10652	31152-31154	PRP	denotes	it
T10653	31155-31157	VBZ	denotes	is
T10654	31167-31169	IN	denotes	to
T10655	31170-31172	IN	denotes	in
T10656	31173-31180	JJ	denotes	several
T10657	31181-31190	NNS	denotes	databases
T10658	31191-31193	IN	denotes	as
T10659	31194-31202	JJ	denotes	putative
T10660	31208-31219	NN	denotes	transporter
T10661	31203-31207	NN	denotes	zinc
T10662	31219-31220	.	denotes	.
T10663	31220-31348	sentence	denotes	It has been previously shown that MTF-1 is important for both basal expression and metal induction of the mouse Znt1 gene (19).
T10664	31221-31223	PRP	denotes	It
T10665	31244-31249	VBN	denotes	shown
T10666	31224-31227	VBZ	denotes	has
T10667	31228-31232	VBN	denotes	been
T10668	31233-31243	RB	denotes	previously
T10669	31250-31254	IN	denotes	that
T10670	31261-31263	VBZ	denotes	is
T10671	31255-31258	NN	denotes	MTF
T10672	31258-31259	HYPH	denotes	-
T10673	31259-31260	CD	denotes	1
T10674	31264-31273	JJ	denotes	important
T10675	31274-31277	IN	denotes	for
T10676	31278-31282	CC	denotes	both
T10677	31289-31299	NN	denotes	expression
T10678	31283-31288	JJ	denotes	basal
T10679	31300-31303	CC	denotes	and
T10680	31304-31309	NN	denotes	metal
T10681	31310-31319	NN	denotes	induction
T10682	31320-31322	IN	denotes	of
T10683	31323-31326	DT	denotes	the
T10684	31338-31342	NN	denotes	gene
T10685	31327-31332	NN	denotes	mouse
T10686	31333-31337	NN	denotes	Znt1
T10687	31343-31344	-LRB-	denotes	(
T10688	31344-31346	CD	denotes	19
T10689	31346-31347	-RRB-	denotes	)
T10690	31347-31348	.	denotes	.
T10691	31348-31517	sentence	denotes	ZnT proteins represent a different family of transporters that reduce intracellular cytoplasmic zinc by promoting zinc efflux from cells or into intracellular vesicles.
T10692	31349-31352	NN	denotes	ZnT
T10693	31353-31361	NN	denotes	proteins
T10694	31362-31371	VBP	denotes	represent
T10695	31372-31373	DT	denotes	a
T10696	31384-31390	NN	denotes	family
T10697	31374-31383	JJ	denotes	different
T10698	31391-31393	IN	denotes	of
T10699	31394-31406	NNS	denotes	transporters
T10700	31407-31411	WDT	denotes	that
T10701	31412-31418	VBP	denotes	reduce
T10702	31419-31432	JJ	denotes	intracellular
T10703	31445-31449	NN	denotes	zinc
T10704	31433-31444	JJ	denotes	cytoplasmic
T10705	31450-31452	IN	denotes	by
T10706	31453-31462	VBG	denotes	promoting
T10707	31463-31467	NN	denotes	zinc
T10708	31468-31474	NN	denotes	efflux
T10709	31475-31479	IN	denotes	from
T10710	31480-31485	NNS	denotes	cells
T10711	31486-31488	CC	denotes	or
T10712	31489-31493	IN	denotes	into
T10713	31494-31507	JJ	denotes	intracellular
T10714	31508-31516	NNS	denotes	vesicles
T10715	31516-31517	.	denotes	.
T10716	31517-31647	sentence	denotes	Thus, members of the ZnT and ZIP family with zinc as predominant substrate have opposite roles in cellular zinc homeostasis (43).
T10717	31518-31522	RB	denotes	Thus
T10718	31593-31597	VBP	denotes	have
T10719	31522-31524	,	denotes	,
T10720	31524-31531	NNS	denotes	members
T10721	31532-31534	IN	denotes	of
T10722	31535-31538	DT	denotes	the
T10723	31551-31557	NN	denotes	family
T10724	31539-31542	NN	denotes	ZnT
T10725	31543-31546	CC	denotes	and
T10726	31547-31550	NN	denotes	ZIP
T10727	31558-31562	IN	denotes	with
T10728	31563-31567	NN	denotes	zinc
T10729	31568-31570	IN	denotes	as
T10730	31571-31582	JJ	denotes	predominant
T10731	31583-31592	NN	denotes	substrate
T10732	31598-31606	JJ	denotes	opposite
T10733	31607-31612	NNS	denotes	roles
T10734	31613-31615	IN	denotes	in
T10735	31616-31624	JJ	denotes	cellular
T10736	31630-31641	NN	denotes	homeostasis
T10737	31625-31629	NN	denotes	zinc
T10738	31642-31643	-LRB-	denotes	(
T10739	31643-31645	CD	denotes	43
T10740	31645-31646	-RRB-	denotes	)
T10741	31646-31647	.	denotes	.
T10742	31647-31812	sentence	denotes	Assuming that SLC39A10 is indeed a zinc transporter, MTF-1 would control expression of two zinc transporters with antagonistic functions, namely, Znt1 and Slc39a10.
T10743	31648-31656	VBG	denotes	Assuming
T10744	31713-31720	VB	denotes	control
T10745	31657-31661	IN	denotes	that
T10746	31671-31673	VBZ	denotes	is
T10747	31662-31670	NN	denotes	SLC39A10
T10748	31674-31680	RB	denotes	indeed
T10749	31681-31682	DT	denotes	a
T10750	31688-31699	NN	denotes	transporter
T10751	31683-31687	NN	denotes	zinc
T10752	31699-31701	,	denotes	,
T10753	31701-31704	NN	denotes	MTF
T10754	31704-31705	HYPH	denotes	-
T10755	31705-31706	CD	denotes	1
T10756	31707-31712	MD	denotes	would
T10757	31721-31731	NN	denotes	expression
T10758	31732-31734	IN	denotes	of
T10759	31735-31738	CD	denotes	two
T10760	31744-31756	NNS	denotes	transporters
T10761	31739-31743	NN	denotes	zinc
T10762	31757-31761	IN	denotes	with
T10763	31762-31774	JJ	denotes	antagonistic
T10764	31775-31784	NNS	denotes	functions
T10765	31784-31786	,	denotes	,
T10766	31786-31792	RB	denotes	namely
T10767	31794-31798	NN	denotes	Znt1
T10768	31792-31794	,	denotes	,
T10769	31799-31802	CC	denotes	and
T10770	31803-31811	NN	denotes	Slc39a10
T10771	31811-31812	.	denotes	.
T10772	31812-31923	sentence	denotes	Specific binding of MTF-1 was observed for an MRE located just downstream of the Slc39a10 transcription start.
T10773	31813-31821	JJ	denotes	Specific
T10774	31822-31829	NN	denotes	binding
T10775	31843-31851	VBN	denotes	observed
T10776	31830-31832	IN	denotes	of
T10777	31833-31836	NN	denotes	MTF
T10778	31836-31837	HYPH	denotes	-
T10779	31837-31838	CD	denotes	1
T10780	31839-31842	VBD	denotes	was
T10781	31852-31855	IN	denotes	for
T10782	31856-31858	DT	denotes	an
T10783	31859-31862	NN	denotes	MRE
T10784	31863-31870	VBN	denotes	located
T10785	31871-31875	RB	denotes	just
T10786	31876-31886	RB	denotes	downstream
T10787	31887-31889	IN	denotes	of
T10788	31890-31893	DT	denotes	the
T10789	31917-31922	NN	denotes	start
T10790	31894-31902	NN	denotes	Slc39a10
T10791	31903-31916	NN	denotes	transcription
T10792	31922-31923	.	denotes	.
T10793	31923-32144	sentence	denotes	In a simple model, such a binding could interfere with the accessibility of the transcriptional start site for RNA polymerase II and/or general transcription factors, thus preventing transcription initiation of the gene.
T10794	31924-31926	IN	denotes	In
T10795	31964-31973	VB	denotes	interfere
T10796	31927-31928	DT	denotes	a
T10797	31936-31941	NN	denotes	model
T10798	31929-31935	JJ	denotes	simple
T10799	31941-31943	,	denotes	,
T10800	31943-31947	PDT	denotes	such
T10801	31950-31957	NN	denotes	binding
T10802	31948-31949	DT	denotes	a
T10803	31958-31963	MD	denotes	could
T10804	31974-31978	IN	denotes	with
T10805	31979-31982	DT	denotes	the
T10806	31983-31996	NN	denotes	accessibility
T10807	31997-31999	IN	denotes	of
T10808	32000-32003	DT	denotes	the
T10809	32026-32030	NN	denotes	site
T10810	32004-32019	JJ	denotes	transcriptional
T10811	32020-32025	NN	denotes	start
T10812	32031-32034	IN	denotes	for
T10813	32035-32038	NN	denotes	RNA
T10814	32039-32049	NN	denotes	polymerase
T10815	32050-32052	CD	denotes	II
T10816	32053-32056	CC	denotes	and
T10817	32056-32057	HYPH	denotes	/
T10818	32057-32059	CC	denotes	or
T10819	32060-32067	JJ	denotes	general
T10820	32082-32089	NNS	denotes	factors
T10821	32068-32081	NN	denotes	transcription
T10822	32089-32091	,	denotes	,
T10823	32091-32095	RB	denotes	thus
T10824	32096-32106	VBG	denotes	preventing
T10825	32107-32120	NN	denotes	transcription
T10826	32121-32131	NN	denotes	initiation
T10827	32132-32134	IN	denotes	of
T10828	32135-32138	DT	denotes	the
T10829	32139-32143	NN	denotes	gene
T10830	32143-32144	.	denotes	.
T10831	32144-32311	sentence	denotes	Indeed, such a mechanism has been described in yeast for the zinc-responsive activator protein 1 (Zap1) and its target gene, zinc-regulated transporter 2 (ZRT2) (64).
T10832	32145-32151	RB	denotes	Indeed
T10833	32179-32188	VBN	denotes	described
T10834	32151-32153	,	denotes	,
T10835	32153-32157	PDT	denotes	such
T10836	32160-32169	NN	denotes	mechanism
T10837	32158-32159	DT	denotes	a
T10838	32170-32173	VBZ	denotes	has
T10839	32174-32178	VBN	denotes	been
T10840	32189-32191	IN	denotes	in
T10841	32192-32197	NN	denotes	yeast
T10842	32198-32201	IN	denotes	for
T10843	32202-32205	DT	denotes	the
T10844	32232-32239	NN	denotes	protein
T10845	32206-32210	NN	denotes	zinc
T10846	32211-32221	JJ	denotes	responsive
T10847	32210-32211	HYPH	denotes	-
T10848	32222-32231	NN	denotes	activator
T10849	32240-32241	CD	denotes	1
T10850	32242-32243	-LRB-	denotes	(
T10851	32243-32247	NN	denotes	Zap1
T10852	32247-32248	-RRB-	denotes	)
T10853	32249-32252	CC	denotes	and
T10854	32253-32256	PRP$	denotes	its
T10855	32264-32268	NN	denotes	gene
T10856	32257-32263	NN	denotes	target
T10857	32268-32270	,	denotes	,
T10858	32270-32274	NN	denotes	zinc
T10859	32285-32296	NN	denotes	transporter
T10860	32274-32275	HYPH	denotes	-
T10861	32275-32284	VBN	denotes	regulated
T10862	32297-32298	CD	denotes	2
T10863	32299-32300	-LRB-	denotes	(
T10864	32300-32304	NN	denotes	ZRT2
T10865	32304-32305	-RRB-	denotes	)
T10866	32306-32307	-LRB-	denotes	(
T10867	32307-32309	CD	denotes	64
T10868	32309-32310	-RRB-	denotes	)
T10869	32310-32311	.	denotes	.
T10870	32311-32433	sentence	denotes	However, the inhibition of Slc39a10 expression by MTF-1 may well be more complex than a competition for promoter binding.
T10871	32312-32319	RB	denotes	However
T10872	32377-32379	VB	denotes	be
T10873	32319-32321	,	denotes	,
T10874	32321-32324	DT	denotes	the
T10875	32325-32335	NN	denotes	inhibition
T10876	32336-32338	IN	denotes	of
T10877	32339-32347	NN	denotes	Slc39a10
T10878	32348-32358	NN	denotes	expression
T10879	32359-32361	IN	denotes	by
T10880	32362-32365	NN	denotes	MTF
T10881	32365-32366	HYPH	denotes	-
T10882	32366-32367	CD	denotes	1
T10883	32368-32371	MD	denotes	may
T10884	32372-32376	RB	denotes	well
T10885	32380-32384	RBR	denotes	more
T10886	32385-32392	JJ	denotes	complex
T10887	32393-32397	IN	denotes	than
T10888	32398-32399	DT	denotes	a
T10889	32400-32411	NN	denotes	competition
T10890	32412-32415	IN	denotes	for
T10891	32416-32424	NN	denotes	promoter
T10892	32425-32432	NN	denotes	binding
T10893	32432-32433	.	denotes	.
T10894	32433-32589	sentence	denotes	Independent of MTF-1, cadmium treatment also leads to downregulation of Slc39a10 transcripts, suggesting that some other factor is mediating this response.
T10895	32434-32445	JJ	denotes	Independent
T10896	32479-32484	VBZ	denotes	leads
T10897	32446-32448	IN	denotes	of
T10898	32449-32452	NN	denotes	MTF
T10899	32452-32453	HYPH	denotes	-
T10900	32453-32454	CD	denotes	1
T10901	32454-32456	,	denotes	,
T10902	32456-32463	NN	denotes	cadmium
T10903	32464-32473	NN	denotes	treatment
T10904	32474-32478	RB	denotes	also
T10905	32485-32487	IN	denotes	to
T10906	32488-32502	NN	denotes	downregulation
T10907	32503-32505	IN	denotes	of
T10908	32506-32514	NN	denotes	Slc39a10
T10909	32515-32526	NNS	denotes	transcripts
T10910	32526-32528	,	denotes	,
T10911	32528-32538	VBG	denotes	suggesting
T10912	32539-32543	IN	denotes	that
T10913	32565-32574	VBG	denotes	mediating
T10914	32544-32548	DT	denotes	some
T10915	32555-32561	NN	denotes	factor
T10916	32549-32554	JJ	denotes	other
T10917	32562-32564	VBZ	denotes	is
T10918	32575-32579	DT	denotes	this
T10919	32580-32588	NN	denotes	response
T10920	32588-32589	.	denotes	.
T10921	32589-32888	sentence	denotes	A previous target gene search for MTF-1 with mouse embryos of conventional Mtf1 knockout phenotype revealed, besides metallothionein genes, the multifunctional alpha-fetoprotein (Afp) and the liver-enriched transcription factor CCAAT/enhancer binding protein alpha (Cebpa) as prime candidates (65).
T10922	32590-32591	DT	denotes	A
T10923	32613-32619	NN	denotes	search
T10924	32592-32600	JJ	denotes	previous
T10925	32601-32607	NN	denotes	target
T10926	32608-32612	NN	denotes	gene
T10927	32689-32697	VBD	denotes	revealed
T10928	32620-32623	IN	denotes	for
T10929	32624-32627	NN	denotes	MTF
T10930	32627-32628	HYPH	denotes	-
T10931	32628-32629	CD	denotes	1
T10932	32630-32634	IN	denotes	with
T10933	32635-32640	NN	denotes	mouse
T10934	32641-32648	NNS	denotes	embryos
T10935	32649-32651	IN	denotes	of
T10936	32652-32664	JJ	denotes	conventional
T10937	32679-32688	NN	denotes	phenotype
T10938	32665-32669	NN	denotes	Mtf1
T10939	32670-32678	NN	denotes	knockout
T10940	32697-32699	,	denotes	,
T10941	32699-32706	IN	denotes	besides
T10942	32707-32722	NN	denotes	metallothionein
T10943	32723-32728	NNS	denotes	genes
T10944	32728-32730	,	denotes	,
T10945	32730-32733	DT	denotes	the
T10946	32756-32767	NN	denotes	fetoprotein
T10947	32734-32749	JJ	denotes	multifunctional
T10948	32750-32755	NN	denotes	alpha
T10949	32755-32756	HYPH	denotes	-
T10950	32768-32769	-LRB-	denotes	(
T10951	32769-32772	NN	denotes	Afp
T10952	32772-32773	-RRB-	denotes	)
T10953	32774-32777	CC	denotes	and
T10954	32778-32781	DT	denotes	the
T10955	32811-32817	NN	denotes	factor
T10956	32782-32787	NN	denotes	liver
T10957	32788-32796	VBN	denotes	enriched
T10958	32787-32788	HYPH	denotes	-
T10959	32797-32810	NN	denotes	transcription
T10960	32818-32823	NN	denotes	CCAAT
T10961	32841-32848	NN	denotes	protein
T10962	32823-32824	HYPH	denotes	/
T10963	32824-32832	NN	denotes	enhancer
T10964	32833-32840	NN	denotes	binding
T10965	32849-32854	SYM	denotes	alpha
T10966	32855-32856	-LRB-	denotes	(
T10967	32856-32861	NN	denotes	Cebpa
T10968	32861-32862	-RRB-	denotes	)
T10969	32863-32865	IN	denotes	as
T10970	32866-32871	JJ	denotes	prime
T10971	32872-32882	NNS	denotes	candidates
T10972	32883-32884	-LRB-	denotes	(
T10973	32884-32886	CD	denotes	65
T10974	32886-32887	-RRB-	denotes	)
T10975	32887-32888	.	denotes	.
T10976	32888-33001	sentence	denotes	After an early onset during hepatogenesis, Afp expression is repressed postnatally and replaced by albumin (66).
T10977	32889-32894	IN	denotes	After
T10978	32950-32959	VBN	denotes	repressed
T10979	32895-32897	DT	denotes	an
T10980	32904-32909	NN	denotes	onset
T10981	32898-32903	JJ	denotes	early
T10982	32910-32916	IN	denotes	during
T10983	32917-32930	NN	denotes	hepatogenesis
T10984	32930-32932	,	denotes	,
T10985	32932-32935	NN	denotes	Afp
T10986	32936-32946	NN	denotes	expression
T10987	32947-32949	VBZ	denotes	is
T10988	32960-32971	RB	denotes	postnatally
T10989	32972-32975	CC	denotes	and
T10990	32976-32984	VBN	denotes	replaced
T10991	32985-32987	IN	denotes	by
T10992	32988-32995	NN	denotes	albumin
T10993	32996-32997	-LRB-	denotes	(
T10994	32997-32999	CD	denotes	66
T10995	32999-33000	-RRB-	denotes	)
T10996	33000-33001	.	denotes	.
T10997	33001-33092	sentence	denotes	Thus, our adult Mtf1Mx-cre mice lacking MTF-1 were not suitable to analyze Afp expression.
T10998	33002-33006	RB	denotes	Thus
T10999	33048-33052	VBD	denotes	were
T11000	33006-33008	,	denotes	,
T11001	33008-33011	PRP$	denotes	our
T11002	33029-33033	NNS	denotes	mice
T11003	33012-33017	JJ	denotes	adult
T11004	33018-33024	NN	denotes	Mtf1Mx
T11005	33025-33028	NN	denotes	cre
T11006	33024-33025	HYPH	denotes	-
T11007	33034-33041	VBG	denotes	lacking
T11008	33042-33045	NN	denotes	MTF
T11009	33045-33046	HYPH	denotes	-
T11010	33046-33047	CD	denotes	1
T11011	33053-33056	RB	denotes	not
T11012	33057-33065	JJ	denotes	suitable
T11013	33066-33068	TO	denotes	to
T11014	33069-33076	VB	denotes	analyze
T11015	33077-33080	NN	denotes	Afp
T11016	33081-33091	NN	denotes	expression
T11017	33091-33092	.	denotes	.
T11018	33092-33311	sentence	denotes	Cebpa is expressed in the adult liver as well as in other tissues (67), but the present microarray data revealed no significant expression differences in livers from adult Mtf1loxP and Mtf1Mx-cre mice (data not shown).
T11019	33093-33098	NN	denotes	Cebpa
T11020	33102-33111	VBN	denotes	expressed
T11021	33099-33101	VBZ	denotes	is
T11022	33112-33114	IN	denotes	in
T11023	33115-33118	DT	denotes	the
T11024	33125-33130	NN	denotes	liver
T11025	33119-33124	JJ	denotes	adult
T11026	33131-33133	RB	denotes	as
T11027	33139-33141	IN	denotes	as
T11028	33134-33138	RB	denotes	well
T11029	33142-33144	IN	denotes	in
T11030	33145-33150	JJ	denotes	other
T11031	33151-33158	NNS	denotes	tissues
T11032	33159-33160	-LRB-	denotes	(
T11033	33160-33162	CD	denotes	67
T11034	33162-33163	-RRB-	denotes	)
T11035	33163-33165	,	denotes	,
T11036	33165-33168	CC	denotes	but
T11037	33169-33172	DT	denotes	the
T11038	33192-33196	NNS	denotes	data
T11039	33173-33180	JJ	denotes	present
T11040	33181-33191	NN	denotes	microarray
T11041	33197-33205	VBD	denotes	revealed
T11042	33206-33208	DT	denotes	no
T11043	33232-33243	NNS	denotes	differences
T11044	33209-33220	JJ	denotes	significant
T11045	33221-33231	NN	denotes	expression
T11046	33244-33246	IN	denotes	in
T11047	33247-33253	NNS	denotes	livers
T11048	33254-33258	IN	denotes	from
T11049	33259-33264	JJ	denotes	adult
T11050	33289-33293	NNS	denotes	mice
T11051	33265-33273	NN	denotes	Mtf1loxP
T11052	33274-33277	CC	denotes	and
T11053	33278-33284	NN	denotes	Mtf1Mx
T11054	33285-33288	NN	denotes	cre
T11055	33284-33285	HYPH	denotes	-
T11056	33294-33295	-LRB-	denotes	(
T11057	33304-33309	VBN	denotes	shown
T11058	33295-33299	NNS	denotes	data
T11059	33300-33303	RB	denotes	not
T11060	33309-33310	-RRB-	denotes	)
T11061	33310-33311	.	denotes	.
T11062	33311-33448	sentence	denotes	Therefore, MTF-1 may affect Cebpa expression only during embryonal development, perhaps in combination with as yet unidentified factors.
T11063	33312-33321	RB	denotes	Therefore
T11064	33333-33339	VB	denotes	affect
T11065	33321-33323	,	denotes	,
T11066	33323-33326	NN	denotes	MTF
T11067	33326-33327	HYPH	denotes	-
T11068	33327-33328	CD	denotes	1
T11069	33329-33332	MD	denotes	may
T11070	33340-33345	NN	denotes	Cebpa
T11071	33346-33356	NN	denotes	expression
T11072	33357-33361	RB	denotes	only
T11073	33362-33368	IN	denotes	during
T11074	33369-33378	JJ	denotes	embryonal
T11075	33379-33390	NN	denotes	development
T11076	33390-33392	,	denotes	,
T11077	33392-33399	RB	denotes	perhaps
T11078	33400-33402	IN	denotes	in
T11079	33403-33414	NN	denotes	combination
T11080	33415-33419	IN	denotes	with
T11081	33420-33422	RB	denotes	as
T11082	33423-33426	RB	denotes	yet
T11083	33427-33439	JJ	denotes	unidentified
T11084	33440-33447	NNS	denotes	factors
T11085	33447-33448	.	denotes	.
T11086	33448-33548	sentence	denotes	The present study confirms and extends the role of MTF-1 as an important stress response regulator.
T11087	33449-33452	DT	denotes	The
T11088	33461-33466	NN	denotes	study
T11089	33453-33460	JJ	denotes	present
T11090	33467-33475	VBZ	denotes	confirms
T11091	33476-33479	CC	denotes	and
T11092	33480-33487	VBZ	denotes	extends
T11093	33488-33491	DT	denotes	the
T11094	33492-33496	NN	denotes	role
T11095	33497-33499	IN	denotes	of
T11096	33500-33503	NN	denotes	MTF
T11097	33503-33504	HYPH	denotes	-
T11098	33504-33505	CD	denotes	1
T11099	33506-33508	IN	denotes	as
T11100	33509-33511	DT	denotes	an
T11101	33538-33547	NN	denotes	regulator
T11102	33512-33521	JJ	denotes	important
T11103	33522-33528	NN	denotes	stress
T11104	33529-33537	NN	denotes	response
T11105	33547-33548	.	denotes	.
T11106	33548-33785	sentence	denotes	We have identified and preliminarily characterized four target genes of MTF-1 in the adult mouse liver: in the case of Sepw1, MTF-1 is required to maintain basal expression, supporting a role of mouse MTF-1 in oxidative stress response.
T11107	33549-33551	PRP	denotes	We
T11108	33557-33567	VBN	denotes	identified
T11109	33552-33556	VBP	denotes	have
T11110	33684-33692	VBN	denotes	required
T11111	33568-33571	CC	denotes	and
T11112	33572-33585	RB	denotes	preliminarily
T11113	33586-33599	VBN	denotes	characterized
T11114	33600-33604	CD	denotes	four
T11115	33612-33617	NNS	denotes	genes
T11116	33605-33611	NN	denotes	target
T11117	33618-33620	IN	denotes	of
T11118	33621-33624	NN	denotes	MTF
T11119	33624-33625	HYPH	denotes	-
T11120	33625-33626	CD	denotes	1
T11121	33627-33629	IN	denotes	in
T11122	33630-33633	DT	denotes	the
T11123	33646-33651	NN	denotes	liver
T11124	33634-33639	JJ	denotes	adult
T11125	33640-33645	NN	denotes	mouse
T11126	33651-33653	:	denotes	:
T11127	33653-33655	IN	denotes	in
T11128	33656-33659	DT	denotes	the
T11129	33660-33664	NN	denotes	case
T11130	33665-33667	IN	denotes	of
T11131	33668-33673	NN	denotes	Sepw1
T11132	33673-33675	,	denotes	,
T11133	33675-33678	NN	denotes	MTF
T11134	33678-33679	HYPH	denotes	-
T11135	33679-33680	CD	denotes	1
T11136	33681-33683	VBZ	denotes	is
T11137	33693-33695	TO	denotes	to
T11138	33696-33704	VB	denotes	maintain
T11139	33705-33710	JJ	denotes	basal
T11140	33711-33721	NN	denotes	expression
T11141	33721-33723	,	denotes	,
T11142	33723-33733	VBG	denotes	supporting
T11143	33734-33735	DT	denotes	a
T11144	33736-33740	NN	denotes	role
T11145	33741-33743	IN	denotes	of
T11146	33744-33749	NN	denotes	mouse
T11147	33750-33753	NN	denotes	MTF
T11148	33753-33754	HYPH	denotes	-
T11149	33754-33755	CD	denotes	1
T11150	33756-33758	IN	denotes	in
T11151	33759-33768	JJ	denotes	oxidative
T11152	33776-33784	NN	denotes	response
T11153	33769-33775	NN	denotes	stress
T11154	33784-33785	.	denotes	.
T11155	33785-33870	sentence	denotes	In addition, MTF-1 contributes to the cadmium-induced expression of Ndrg1 and Csrp1.
T11156	33786-33788	IN	denotes	In
T11157	33805-33816	VBZ	denotes	contributes
T11158	33789-33797	NN	denotes	addition
T11159	33797-33799	,	denotes	,
T11160	33799-33802	NN	denotes	MTF
T11161	33802-33803	HYPH	denotes	-
T11162	33803-33804	CD	denotes	1
T11163	33817-33819	IN	denotes	to
T11164	33820-33823	DT	denotes	the
T11165	33840-33850	NN	denotes	expression
T11166	33824-33831	NN	denotes	cadmium
T11167	33832-33839	VBN	denotes	induced
T11168	33831-33832	HYPH	denotes	-
T11169	33851-33853	IN	denotes	of
T11170	33854-33859	NN	denotes	Ndrg1
T11171	33860-33863	CC	denotes	and
T11172	33864-33869	NN	denotes	Csrp1
T11173	33869-33870	.	denotes	.
T11174	33870-34026	sentence	denotes	Furthermore, MTF-1 helps to repress the basal expression of Slc39a10, in contrast to its role as transcriptional activator for genes like Mt1, Mt2 or Znt1.
T11175	33871-33882	RB	denotes	Furthermore
T11176	33890-33895	VBZ	denotes	helps
T11177	33882-33884	,	denotes	,
T11178	33884-33887	NN	denotes	MTF
T11179	33887-33888	HYPH	denotes	-
T11180	33888-33889	CD	denotes	1
T11181	33896-33898	TO	denotes	to
T11182	33899-33906	VB	denotes	repress
T11183	33907-33910	DT	denotes	the
T11184	33917-33927	NN	denotes	expression
T11185	33911-33916	JJ	denotes	basal
T11186	33928-33930	IN	denotes	of
T11187	33931-33939	NN	denotes	Slc39a10
T11188	33939-33941	,	denotes	,
T11189	33941-33943	IN	denotes	in
T11190	33944-33952	NN	denotes	contrast
T11191	33953-33955	IN	denotes	to
T11192	33956-33959	PRP$	denotes	its
T11193	33960-33964	NN	denotes	role
T11194	33965-33967	IN	denotes	as
T11195	33968-33983	JJ	denotes	transcriptional
T11196	33984-33993	NN	denotes	activator
T11197	33994-33997	IN	denotes	for
T11198	33998-34003	NNS	denotes	genes
T11199	34004-34008	IN	denotes	like
T11200	34009-34012	NN	denotes	Mt1
T11201	34012-34014	,	denotes	,
T11202	34014-34017	NN	denotes	Mt2
T11203	34018-34020	CC	denotes	or
T11204	34021-34025	NN	denotes	Znt1
T11205	34025-34026	.	denotes	.
T11206	34026-34139	sentence	denotes	Thus the same transcription factor apparently serves as an activator or repressor, depending on the target gene.
T11207	34027-34031	RB	denotes	Thus
T11208	34073-34079	VBZ	denotes	serves
T11209	34032-34035	DT	denotes	the
T11210	34055-34061	NN	denotes	factor
T11211	34036-34040	JJ	denotes	same
T11212	34041-34054	NN	denotes	transcription
T11213	34062-34072	RB	denotes	apparently
T11214	34080-34082	IN	denotes	as
T11215	34083-34085	DT	denotes	an
T11216	34086-34095	NN	denotes	activator
T11217	34096-34098	CC	denotes	or
T11218	34099-34108	NN	denotes	repressor
T11219	34108-34110	,	denotes	,
T11220	34110-34119	VBG	denotes	depending
T11221	34120-34122	IN	denotes	on
T11222	34123-34126	DT	denotes	the
T11223	34134-34138	NN	denotes	gene
T11224	34127-34133	NN	denotes	target
T11225	34138-34139	.	denotes	.
T11226	34139-34336	sentence	denotes	The comparison of liver gene expression of cadmium- and mock-treated mice also revealed a number of genes that were responsive to cadmium exposure, independent of the presence or absence of MTF-1.
T11227	34140-34143	DT	denotes	The
T11228	34144-34154	NN	denotes	comparison
T11229	34219-34227	VBD	denotes	revealed
T11230	34155-34157	IN	denotes	of
T11231	34158-34163	NN	denotes	liver
T11232	34164-34168	NN	denotes	gene
T11233	34169-34179	NN	denotes	expression
T11234	34180-34182	IN	denotes	of
T11235	34183-34190	NN	denotes	cadmium
T11236	34201-34208	VBN	denotes	treated
T11237	34190-34191	HYPH	denotes	-
T11238	34192-34195	CC	denotes	and
T11239	34196-34200	JJ	denotes	mock
T11240	34200-34201	HYPH	denotes	-
T11241	34209-34213	NNS	denotes	mice
T11242	34214-34218	RB	denotes	also
T11243	34228-34229	DT	denotes	a
T11244	34230-34236	NN	denotes	number
T11245	34237-34239	IN	denotes	of
T11246	34240-34245	NNS	denotes	genes
T11247	34246-34250	WDT	denotes	that
T11248	34251-34255	VBD	denotes	were
T11249	34256-34266	JJ	denotes	responsive
T11250	34267-34269	IN	denotes	to
T11251	34270-34277	NN	denotes	cadmium
T11252	34278-34286	NN	denotes	exposure
T11253	34286-34288	,	denotes	,
T11254	34288-34299	JJ	denotes	independent
T11255	34300-34302	IN	denotes	of
T11256	34303-34306	DT	denotes	the
T11257	34307-34315	NN	denotes	presence
T11258	34316-34318	CC	denotes	or
T11259	34319-34326	NN	denotes	absence
T11260	34327-34329	IN	denotes	of
T11261	34330-34333	NN	denotes	MTF
T11262	34333-34334	HYPH	denotes	-
T11263	34334-34335	CD	denotes	1
T11264	34335-34336	.	denotes	.
T11265	34336-34603	sentence	denotes	Evidence suggests that the production of reactive oxygen species is a major effect of acute cadmium toxicity (68,69), and exposure of cultured cells or animals to cadmium is associated with depletion of reduced glutathione, lipid peroxidation and DNA damage (70–73).
T11266	34337-34345	NN	denotes	Evidence
T11267	34508-34510	VBZ	denotes	is
T11268	34346-34354	VBZ	denotes	suggests
T11269	34355-34359	IN	denotes	that
T11270	34402-34404	VBZ	denotes	is
T11271	34360-34363	DT	denotes	the
T11272	34364-34374	NN	denotes	production
T11273	34375-34377	IN	denotes	of
T11274	34378-34386	JJ	denotes	reactive
T11275	34394-34401	NNS	denotes	species
T11276	34387-34393	NN	denotes	oxygen
T11277	34405-34406	DT	denotes	a
T11278	34413-34419	NN	denotes	effect
T11279	34407-34412	JJ	denotes	major
T11280	34420-34422	IN	denotes	of
T11281	34423-34428	JJ	denotes	acute
T11282	34437-34445	NN	denotes	toxicity
T11283	34429-34436	NN	denotes	cadmium
T11284	34446-34447	-LRB-	denotes	(
T11285	34450-34452	CD	denotes	69
T11286	34447-34449	CD	denotes	68
T11287	34449-34450	,	denotes	,
T11288	34452-34453	-RRB-	denotes	)
T11289	34453-34455	,	denotes	,
T11290	34455-34458	CC	denotes	and
T11291	34459-34467	NN	denotes	exposure
T11292	34468-34470	IN	denotes	of
T11293	34471-34479	VBN	denotes	cultured
T11294	34480-34485	NNS	denotes	cells
T11295	34486-34488	CC	denotes	or
T11296	34489-34496	NNS	denotes	animals
T11297	34497-34499	IN	denotes	to
T11298	34500-34507	NN	denotes	cadmium
T11299	34511-34521	JJ	denotes	associated
T11300	34522-34526	IN	denotes	with
T11301	34527-34536	NN	denotes	depletion
T11302	34537-34539	IN	denotes	of
T11303	34540-34547	VBN	denotes	reduced
T11304	34548-34559	NN	denotes	glutathione
T11305	34559-34561	,	denotes	,
T11306	34561-34566	NN	denotes	lipid
T11307	34567-34579	NN	denotes	peroxidation
T11308	34580-34583	CC	denotes	and
T11309	34584-34587	NN	denotes	DNA
T11310	34588-34594	NN	denotes	damage
T11311	34595-34596	-LRB-	denotes	(
T11312	34596-34598	CD	denotes	70
T11313	34598-34599	SYM	denotes	–
T11314	34599-34601	CD	denotes	73
T11315	34601-34602	-RRB-	denotes	)
T11316	34602-34603	.	denotes	.
T11317	34603-34785	sentence	denotes	Oxidative stress and the subsequent restoration of cellular homeostasis have been shown to induce the expression of genes encoding acute-phase proteins and antioxidant enzymes (74).
T11318	34604-34613	JJ	denotes	Oxidative
T11319	34614-34620	NN	denotes	stress
T11320	34686-34691	VBN	denotes	shown
T11321	34621-34624	CC	denotes	and
T11322	34625-34628	DT	denotes	the
T11323	34640-34651	NN	denotes	restoration
T11324	34629-34639	JJ	denotes	subsequent
T11325	34652-34654	IN	denotes	of
T11326	34655-34663	JJ	denotes	cellular
T11327	34664-34675	NN	denotes	homeostasis
T11328	34676-34680	VBP	denotes	have
T11329	34681-34685	VBN	denotes	been
T11330	34692-34694	TO	denotes	to
T11331	34695-34701	VB	denotes	induce
T11332	34702-34705	DT	denotes	the
T11333	34706-34716	NN	denotes	expression
T11334	34717-34719	IN	denotes	of
T11335	34720-34725	NNS	denotes	genes
T11336	34726-34734	VBG	denotes	encoding
T11337	34735-34740	JJ	denotes	acute
T11338	34741-34746	NN	denotes	phase
T11339	34740-34741	HYPH	denotes	-
T11340	34747-34755	NN	denotes	proteins
T11341	34756-34759	CC	denotes	and
T11342	34760-34771	JJ	denotes	antioxidant
T11343	34772-34779	NNS	denotes	enzymes
T11344	34780-34781	-LRB-	denotes	(
T11345	34781-34783	CD	denotes	74
T11346	34783-34784	-RRB-	denotes	)
T11347	34784-34785	.	denotes	.
T11348	34785-34931	sentence	denotes	In mammals, cadmium tends to accumulate in the kidney and liver as a cadmium-metallothionein complex that has an extremely slow turnover (75,76).
T11349	34786-34788	IN	denotes	In
T11350	34806-34811	VBZ	denotes	tends
T11351	34789-34796	NNS	denotes	mammals
T11352	34796-34798	,	denotes	,
T11353	34798-34805	NN	denotes	cadmium
T11354	34812-34814	TO	denotes	to
T11355	34815-34825	VB	denotes	accumulate
T11356	34826-34828	IN	denotes	in
T11357	34829-34832	DT	denotes	the
T11358	34833-34839	NN	denotes	kidney
T11359	34840-34843	CC	denotes	and
T11360	34844-34849	NN	denotes	liver
T11361	34850-34852	IN	denotes	as
T11362	34853-34854	DT	denotes	a
T11363	34879-34886	NN	denotes	complex
T11364	34855-34862	NN	denotes	cadmium
T11365	34863-34878	NN	denotes	metallothionein
T11366	34862-34863	HYPH	denotes	-
T11367	34887-34891	WDT	denotes	that
T11368	34892-34895	VBZ	denotes	has
T11369	34896-34898	DT	denotes	an
T11370	34914-34922	NN	denotes	turnover
T11371	34899-34908	RB	denotes	extremely
T11372	34909-34913	JJ	denotes	slow
T11373	34923-34924	-LRB-	denotes	(
T11374	34927-34929	CD	denotes	76
T11375	34924-34926	CD	denotes	75
T11376	34926-34927	,	denotes	,
T11377	34929-34930	-RRB-	denotes	)
T11378	34930-34931	.	denotes	.
T11379	34931-35013	sentence	denotes	Furthermore, metallothioneins provide protection against oxidative stress (1,17).
T11380	34932-34943	RB	denotes	Furthermore
T11381	34962-34969	VBP	denotes	provide
T11382	34943-34945	,	denotes	,
T11383	34945-34961	NNS	denotes	metallothioneins
T11384	34970-34980	NN	denotes	protection
T11385	34981-34988	IN	denotes	against
T11386	34989-34998	JJ	denotes	oxidative
T11387	34999-35005	NN	denotes	stress
T11388	35006-35007	-LRB-	denotes	(
T11389	35009-35011	CD	denotes	17
T11390	35007-35008	CD	denotes	1
T11391	35008-35009	,	denotes	,
T11392	35011-35012	-RRB-	denotes	)
T11393	35012-35013	.	denotes	.
T11394	35013-35131	sentence	denotes	In addition to metallothioneins, glutathione was postulated as a first line of defense against cadmium toxicity (77).
T11395	35014-35016	IN	denotes	In
T11396	35063-35073	VBN	denotes	postulated
T11397	35017-35025	NN	denotes	addition
T11398	35026-35028	IN	denotes	to
T11399	35029-35045	NNS	denotes	metallothioneins
T11400	35045-35047	,	denotes	,
T11401	35047-35058	NN	denotes	glutathione
T11402	35059-35062	VBD	denotes	was
T11403	35074-35076	IN	denotes	as
T11404	35077-35078	DT	denotes	a
T11405	35085-35089	NN	denotes	line
T11406	35079-35084	JJ	denotes	first
T11407	35090-35092	IN	denotes	of
T11408	35093-35100	NN	denotes	defense
T11409	35101-35108	IN	denotes	against
T11410	35109-35116	NN	denotes	cadmium
T11411	35117-35125	NN	denotes	toxicity
T11412	35126-35127	-LRB-	denotes	(
T11413	35127-35129	CD	denotes	77
T11414	35129-35130	-RRB-	denotes	)
T11415	35130-35131	.	denotes	.
T11416	35131-35295	sentence	denotes	Glutathione efficiently complexes cadmium (78) and scavenges free radicals and other reactive oxygen species directly, and indirectly via enzymatic reactions (45).
T11417	35132-35143	NN	denotes	Glutathione
T11418	35156-35165	VBZ	denotes	complexes
T11419	35144-35155	RB	denotes	efficiently
T11420	35166-35173	NN	denotes	cadmium
T11421	35174-35175	-LRB-	denotes	(
T11422	35175-35177	CD	denotes	78
T11423	35177-35178	-RRB-	denotes	)
T11424	35179-35182	CC	denotes	and
T11425	35183-35192	VBZ	denotes	scavenges
T11426	35193-35197	JJ	denotes	free
T11427	35198-35206	NNS	denotes	radicals
T11428	35207-35210	CC	denotes	and
T11429	35211-35216	JJ	denotes	other
T11430	35233-35240	NNS	denotes	species
T11431	35217-35225	JJ	denotes	reactive
T11432	35226-35232	NN	denotes	oxygen
T11433	35241-35249	RB	denotes	directly
T11434	35249-35251	,	denotes	,
T11435	35251-35254	CC	denotes	and
T11436	35255-35265	RB	denotes	indirectly
T11437	35266-35269	IN	denotes	via
T11438	35270-35279	JJ	denotes	enzymatic
T11439	35280-35289	NNS	denotes	reactions
T11440	35290-35291	-LRB-	denotes	(
T11441	35291-35293	CD	denotes	45
T11442	35293-35294	-RRB-	denotes	)
T11443	35294-35295	.	denotes	.
T11444	35295-35390	sentence	denotes	In such reactions, glutathione is oxidized and has to be regenerated by glutathione reductase.
T11445	35296-35298	IN	denotes	In
T11446	35330-35338	VBN	denotes	oxidized
T11447	35299-35303	JJ	denotes	such
T11448	35304-35313	NNS	denotes	reactions
T11449	35313-35315	,	denotes	,
T11450	35315-35326	NN	denotes	glutathione
T11451	35327-35329	VBZ	denotes	is
T11452	35339-35342	CC	denotes	and
T11453	35343-35346	VBZ	denotes	has
T11454	35347-35349	TO	denotes	to
T11455	35353-35364	VBN	denotes	regenerated
T11456	35350-35352	VB	denotes	be
T11457	35365-35367	IN	denotes	by
T11458	35368-35379	NN	denotes	glutathione
T11459	35380-35389	NN	denotes	reductase
T11460	35389-35390	.	denotes	.
T11461	35390-35488	sentence	denotes	Also, glutathione-S-transferases mediate the conjugation of various electrophiles to glutathione.
T11462	35391-35395	RB	denotes	Also
T11463	35424-35431	VBP	denotes	mediate
T11464	35395-35397	,	denotes	,
T11465	35397-35408	NN	denotes	glutathione
T11466	35411-35423	NNS	denotes	transferases
T11467	35408-35409	HYPH	denotes	-
T11468	35409-35410	NN	denotes	S
T11469	35410-35411	HYPH	denotes	-
T11470	35432-35435	DT	denotes	the
T11471	35436-35447	NN	denotes	conjugation
T11472	35448-35450	IN	denotes	of
T11473	35451-35458	JJ	denotes	various
T11474	35459-35472	NNS	denotes	electrophiles
T11475	35473-35475	IN	denotes	to
T11476	35476-35487	NN	denotes	glutathione
T11477	35487-35488	.	denotes	.
T11478	35488-35626	sentence	denotes	The observed cadmium-induced upregulation of Gclc, Gsr and Gstm4 supports the importance of glutathione in the cellular cadmium response.
T11479	35489-35492	DT	denotes	The
T11480	35518-35530	NN	denotes	upregulation
T11481	35493-35501	VBN	denotes	observed
T11482	35502-35509	NN	denotes	cadmium
T11483	35510-35517	VBN	denotes	induced
T11484	35509-35510	HYPH	denotes	-
T11485	35554-35562	VBZ	denotes	supports
T11486	35531-35533	IN	denotes	of
T11487	35534-35538	NN	denotes	Gclc
T11488	35538-35540	,	denotes	,
T11489	35540-35543	NN	denotes	Gsr
T11490	35544-35547	CC	denotes	and
T11491	35548-35553	NN	denotes	Gstm4
T11492	35563-35566	DT	denotes	the
T11493	35567-35577	NN	denotes	importance
T11494	35578-35580	IN	denotes	of
T11495	35581-35592	NN	denotes	glutathione
T11496	35593-35595	IN	denotes	in
T11497	35596-35599	DT	denotes	the
T11498	35617-35625	NN	denotes	response
T11499	35600-35608	JJ	denotes	cellular
T11500	35609-35616	NN	denotes	cadmium
T11501	35625-35626	.	denotes	.
T11502	35626-35918	sentence	denotes	The enhanced sensitivity to cadmium toxicity that we found for mouse embryonic fibroblasts upon a combination of Mtf1 deletion and depletion of glutathione further corroborates the importance of MTF-1 and its target genes as well as reduced glutathione for an efficient anti-cadmium defense.
T11503	35627-35630	DT	denotes	The
T11504	35640-35651	NN	denotes	sensitivity
T11505	35631-35639	VBN	denotes	enhanced
T11506	35791-35803	VBZ	denotes	corroborates
T11507	35652-35654	IN	denotes	to
T11508	35655-35662	NN	denotes	cadmium
T11509	35663-35671	NN	denotes	toxicity
T11510	35672-35676	WDT	denotes	that
T11511	35680-35685	VBD	denotes	found
T11512	35677-35679	PRP	denotes	we
T11513	35686-35689	IN	denotes	for
T11514	35690-35695	NN	denotes	mouse
T11515	35706-35717	NNS	denotes	fibroblasts
T11516	35696-35705	JJ	denotes	embryonic
T11517	35718-35722	IN	denotes	upon
T11518	35723-35724	DT	denotes	a
T11519	35725-35736	NN	denotes	combination
T11520	35737-35739	IN	denotes	of
T11521	35740-35744	NN	denotes	Mtf1
T11522	35745-35753	NN	denotes	deletion
T11523	35754-35757	CC	denotes	and
T11524	35758-35767	NN	denotes	depletion
T11525	35768-35770	IN	denotes	of
T11526	35771-35782	NN	denotes	glutathione
T11527	35783-35790	RB	denotes	further
T11528	35804-35807	DT	denotes	the
T11529	35808-35818	NN	denotes	importance
T11530	35819-35821	IN	denotes	of
T11531	35822-35825	NN	denotes	MTF
T11532	35825-35826	HYPH	denotes	-
T11533	35826-35827	CD	denotes	1
T11534	35828-35831	CC	denotes	and
T11535	35832-35835	PRP$	denotes	its
T11536	35843-35848	NNS	denotes	genes
T11537	35836-35842	NN	denotes	target
T11538	35849-35851	RB	denotes	as
T11539	35857-35859	IN	denotes	as
T11540	35852-35856	RB	denotes	well
T11541	35860-35867	VBN	denotes	reduced
T11542	35868-35879	NN	denotes	glutathione
T11543	35880-35883	IN	denotes	for
T11544	35884-35886	DT	denotes	an
T11545	35910-35917	NN	denotes	defense
T11546	35887-35896	JJ	denotes	efficient
T11547	35897-35909	JJ	denotes	anti-cadmium
T11548	35917-35918	.	denotes	.
T11549	35918-36135	sentence	denotes	Our data provide strong evidence for at least two branches of cellular anti-cadmium defense, one via MTF-1 and its target genes, notably metallothioneins, the other via glutathione, with an apparent overlap in Sepw1.
T11550	35919-35922	PRP$	denotes	Our
T11551	35923-35927	NNS	denotes	data
T11552	35928-35935	VBP	denotes	provide
T11553	35936-35942	JJ	denotes	strong
T11554	35943-35951	NN	denotes	evidence
T11555	35952-35955	IN	denotes	for
T11556	35956-35958	RB	denotes	at
T11557	35965-35968	CD	denotes	two
T11558	35959-35964	RBS	denotes	least
T11559	35969-35977	NNS	denotes	branches
T11560	35978-35980	IN	denotes	of
T11561	35981-35989	JJ	denotes	cellular
T11562	36003-36010	NN	denotes	defense
T11563	35990-36002	JJ	denotes	anti-cadmium
T11564	36010-36012	,	denotes	,
T11565	36012-36015	CD	denotes	one
T11566	36016-36019	IN	denotes	via
T11567	36020-36023	NN	denotes	MTF
T11568	36023-36024	HYPH	denotes	-
T11569	36024-36025	CD	denotes	1
T11570	36026-36029	CC	denotes	and
T11571	36030-36033	PRP$	denotes	its
T11572	36041-36046	NNS	denotes	genes
T11573	36034-36040	NN	denotes	target
T11574	36046-36048	,	denotes	,
T11575	36048-36055	RB	denotes	notably
T11576	36056-36072	NNS	denotes	metallothioneins
T11577	36072-36074	,	denotes	,
T11578	36074-36077	DT	denotes	the
T11579	36078-36083	JJ	denotes	other
T11580	36084-36087	IN	denotes	via
T3137	8538-8540	NN	denotes	S1
T3138	8550-8557	NN	denotes	mapping
T3139	8541-8549	NN	denotes	nuclease
T3140	8558-8560	IN	denotes	of
T3141	8561-8572	NNS	denotes	transcripts
T3142	8573-8574	-LRB-	denotes	(
T3143	8577-8585	NN	denotes	analysis
T3144	8574-8576	NN	denotes	S1
T3145	8585-8586	-RRB-	denotes	)
T3146	8586-8723	sentence	denotes	S1 analysis was performed as previously described (29), using 100 µg DNase I-digested total RNA (RNA isolation see microarray analysis).
T3147	8587-8589	NN	denotes	S1
T3148	8590-8598	NN	denotes	analysis
T3149	8603-8612	VBN	denotes	performed
T3150	8599-8602	VBD	denotes	was
T3151	8613-8615	IN	denotes	as
T3152	8627-8636	VBN	denotes	described
T3153	8616-8626	RB	denotes	previously
T3154	8637-8638	-LRB-	denotes	(
T3155	8638-8640	CD	denotes	29
T3156	8640-8641	-RRB-	denotes	)
T3157	8641-8643	,	denotes	,
T3158	8643-8648	VBG	denotes	using
T3159	8649-8652	CD	denotes	100
T3160	8653-8655	NN	denotes	µg
T3161	8679-8682	NN	denotes	RNA
T3162	8656-8661	NN	denotes	DNase
T3163	8664-8672	VBN	denotes	digested
T3184	8770-8779	NNP	denotes	Molecular
T3196	8831-8834	NN	denotes	32P
T3164	8662-8663	CD	denotes	I
T3165	8663-8664	HYPH	denotes	-
T3166	8673-8678	JJ	denotes	total
T3167	8683-8684	-LRB-	denotes	(
T3168	8698-8701	VBP	denotes	see
T3169	8684-8687	NN	denotes	RNA
T3170	8688-8697	NN	denotes	isolation
T3171	8702-8712	NN	denotes	microarray
T3172	8713-8721	NN	denotes	analysis
T3173	8721-8722	-RRB-	denotes	)
T3174	8722-8723	.	denotes	.
T3175	8723-8790	sentence	denotes	The gels were developed using PhosphorImager (Molecular Dynamics).
T3176	8724-8727	DT	denotes	The
T3177	8728-8732	NNS	denotes	gels
T3178	8738-8747	VBN	denotes	developed
T3179	8733-8737	VBD	denotes	were
T3180	8748-8753	VBG	denotes	using
T3181	8754-8768	NNP	denotes	PhosphorImager
T3182	8769-8770	-LRB-	denotes	(
T3183	8780-8788	NNP	denotes	Dynamics
T3185	8788-8789	-RRB-	denotes	)
T3186	8789-8790	.	denotes	.
T3187	8790-9057	sentence	denotes	S1 analysis was done with the following 32P-labeled oligonucleotides: Hprt S1: 5′-TCTTCAGTCTGATAAAATCTACAGTCATAGGAATGGATCTATCACTATTTCTATTCAGTGATTACATTAAAG-3′, Sepw1 S1: 5′-TTCAACCGGGAACACCTGGAAACATGGCTGCCTGTCTTCTTGAAGTCTTGAGGTGGAAAGGGAAAGCAAAGCAGGAGGGTTTTCCCACCC-3′.
T3188	8791-8793	NN	denotes	S1
T3189	8794-8802	NN	denotes	analysis
T3190	8807-8811	VBN	denotes	done
T3191	8803-8806	VBD	denotes	was
T3192	8812-8816	IN	denotes	with
T3193	8817-8820	DT	denotes	the
T3194	8843-8859	NNS	denotes	oligonucleotides
T3195	8821-8830	VBG	denotes	following
T3197	8835-8842	VBN	denotes	labeled
T3198	8834-8835	HYPH	denotes	-
T3199	8859-8861	:	denotes	:
T3200	8861-8865	NN	denotes	Hprt
T3201	8866-8868	NN	denotes	S1
T3202	8868-8870	:	denotes	:
T3203	8870-8871	CD	denotes	5
T3204	8873-8945	NN	denotes	TCTTCAGTCTGATAAAATCTACAGTCATAGGAATGGATCTATCACTATTTCTATTCAGTGATTACATTAAAG
T3205	8871-8872	SYM	denotes	′
T3206	8872-8873	HYPH	denotes	-
T3207	8945-8946	HYPH	denotes	-
T3208	8946-8947	CD	denotes	3
T3209	8947-8948	SYM	denotes	′
T3210	8948-8950	,	denotes	,
T3211	8950-8955	NN	denotes	Sepw1
T3212	8956-8958	NN	denotes	S1
T3213	8958-8960	:	denotes	:
T3214	8960-8961	CD	denotes	5
T3215	8963-9053	NN	denotes	TTCAACCGGGAACACCTGGAAACATGGCTGCCTGTCTTCTTGAAGTCTTGAGGTGGAAAGGGAAAGCAAAGCAGGAGGGTTTTCCCACCC
T3216	8961-8962	SYM	denotes	′
T3217	8962-8963	HYPH	denotes	-
T3218	9053-9054	HYPH	denotes	-
T3219	9054-9055	CD	denotes	3
T3220	9055-9056	SYM	denotes	′
T3221	9056-9057	.	denotes	.
T4279	12590-12602	NN	denotes	Cytotoxicity
T4280	12603-12608	NN	denotes	assay
T4281	12608-12715	sentence	denotes	Samples of 1 × 104 cells/well were plated in 96-well tissue culture plates and allowed to adhere for 24 h.
T4282	12609-12616	NNS	denotes	Samples
T4283	12644-12650	VBN	denotes	plated
T4284	12617-12619	IN	denotes	of
T4285	12620-12621	CD	denotes	1
T4286	12624-12627	CD	denotes	104
T4287	12622-12623	SYM	denotes	×
T4288	12628-12633	NNS	denotes	cells
T4289	12633-12634	SYM	denotes	/
T4290	12634-12638	NN	denotes	well
T4291	12639-12643	VBD	denotes	were
T4292	12651-12653	IN	denotes	in
T4293	12654-12656	CD	denotes	96
T4294	12657-12661	NN	denotes	well
T4295	12656-12657	HYPH	denotes	-
T4296	12677-12683	NNS	denotes	plates
T4297	12662-12668	NN	denotes	tissue
T4298	12669-12676	NN	denotes	culture
T4299	12684-12687	CC	denotes	and
T4300	12688-12695	VBN	denotes	allowed
T4301	12696-12698	TO	denotes	to
T4302	12699-12705	VB	denotes	adhere
T4303	12706-12709	IN	denotes	for
T4304	12710-12712	CD	denotes	24
T4305	12713-12714	NN	denotes	h
T4306	12714-12715	.	denotes	.
T4307	12715-12896	sentence	denotes	The cells were then pre-incubated for 24 h in medium containing 0, 5, 10, 25 or 50 µM l-buthionine-[S,R]-sulfoximine (BSO) (Sigma), a drug that inhibits glutathione synthesis (31).
T4308	12716-12719	DT	denotes	The
T4309	12720-12725	NNS	denotes	cells
T4310	12736-12749	VBN	denotes	pre-incubated
T4311	12726-12730	VBD	denotes	were
T4312	12731-12735	RB	denotes	then
T4313	12750-12753	IN	denotes	for
T4314	12754-12756	CD	denotes	24
T4315	12757-12758	NN	denotes	h
T4316	12759-12761	IN	denotes	in
T4317	12762-12768	NN	denotes	medium
T4318	12769-12779	VBG	denotes	containing
T4319	12780-12781	CD	denotes	0
T4320	12799-12801	NN	denotes	µM
T4321	12781-12783	,	denotes	,
T4322	12783-12784	CD	denotes	5
T4323	12784-12786	,	denotes	,
T4324	12786-12788	CD	denotes	10
T4325	12788-12790	,	denotes	,
T4326	12790-12792	CD	denotes	25
T4327	12793-12795	CC	denotes	or
T4328	12796-12798	CD	denotes	50
T4329	12802-12803	NN	denotes	l
T4330	12821-12832	NN	denotes	sulfoximine
T4331	12803-12804	HYPH	denotes	-
T4332	12804-12814	NN	denotes	buthionine
T4333	12814-12815	HYPH	denotes	-
T4334	12815-12816	-LRB-	denotes	[
T4335	12816-12817	NN	denotes	S
T4336	12817-12818	,	denotes	,
T4337	12818-12819	NN	denotes	R
T4338	12819-12820	-RRB-	denotes	]
T4339	12820-12821	HYPH	denotes	-
T4340	12833-12834	-LRB-	denotes	(
T4341	12834-12837	NN	denotes	BSO
T4342	12837-12838	-RRB-	denotes	)
T4343	12839-12840	-LRB-	denotes	(
T4344	12840-12845	NNP	denotes	Sigma
T4345	12845-12846	-RRB-	denotes	)
T4346	12846-12848	,	denotes	,
T4347	12848-12849	DT	denotes	a
T4348	12850-12854	NN	denotes	drug
T4349	12855-12859	WDT	denotes	that
T4350	12860-12868	VBZ	denotes	inhibits
T4351	12869-12880	NN	denotes	glutathione
T4352	12881-12890	NN	denotes	synthesis
T4353	12891-12892	-LRB-	denotes	(
T4354	12892-12894	CD	denotes	31
T4355	12894-12895	-RRB-	denotes	)
T4356	12895-12896	.	denotes	.
T4357	12896-13012	sentence	denotes	Later, cells were exposed to 0, 5, 10 or 20 µM CdCl2 in the specified pre-incubation medium for an additional 24 h.
T4358	12897-12902	RB	denotes	Later
T4359	12915-12922	VBN	denotes	exposed
T4360	12902-12904	,	denotes	,
T4361	12904-12909	NNS	denotes	cells
T4362	12910-12914	VBD	denotes	were
T4363	12923-12925	IN	denotes	to
T4364	12926-12927	CD	denotes	0
T4365	12941-12943	NN	denotes	µM
T4366	12927-12929	,	denotes	,
T4367	12929-12930	CD	denotes	5
T4368	12930-12932	,	denotes	,
T4369	12932-12934	CD	denotes	10
T4370	12935-12937	CC	denotes	or
T4371	12938-12940	CD	denotes	20
T4372	12944-12949	NN	denotes	CdCl2
T4373	12950-12952	IN	denotes	in
T4374	12953-12956	DT	denotes	the
T4375	12982-12988	NN	denotes	medium
T4376	12957-12966	VBN	denotes	specified
T4377	12967-12981	NN	denotes	pre-incubation
T4378	12989-12992	IN	denotes	for
T4379	12993-12995	DT	denotes	an
T4380	13010-13011	NN	denotes	h
T4381	12996-13006	JJ	denotes	additional
T4382	13007-13009	CD	denotes	24
T4383	13011-13012	.	denotes	.
T2931	8103-8124	NN	denotes	TTCCGATGTGCCAAGTGTGGC
T4384	13012-13199	sentence	denotes	Cytotoxicity was determined by the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromid)-based Cell Proliferation Kit I (Roche) according to the manufacturer's instructions.
T4385	13013-13025	NN	denotes	Cytotoxicity
T4386	13030-13040	VBN	denotes	determined
T4387	13026-13029	VBD	denotes	was
T4388	13041-13043	IN	denotes	by
T4389	13044-13047	DT	denotes	the
T4390	13140-13143	NNP	denotes	Kit
T4391	13048-13051	NN	denotes	MTT
T4392	13115-13120	VBN	denotes	based
T4393	13052-13053	-LRB-	denotes	(
T4394	13107-13113	NN	denotes	bromid
T4395	13053-13054	CD	denotes	3
T4396	13060-13075	NN	denotes	dimethylthiazol
T4397	13054-13055	HYPH	denotes	-
T4398	13055-13056	-LRB-	denotes	[
T4399	13056-13057	CD	denotes	4
T4400	13057-13058	,	denotes	,
T4401	13058-13059	CD	denotes	5
T4402	13059-13060	HYPH	denotes	-
T4403	13075-13076	HYPH	denotes	-
T4404	13076-13077	CD	denotes	2
T4405	13078-13080	NN	denotes	yl
T4406	13077-13078	HYPH	denotes	-
T4407	13080-13081	-RRB-	denotes	]
T4408	13081-13082	HYPH	denotes	-
T4409	13082-13083	CD	denotes	2
T4410	13083-13084	,	denotes	,
T4411	13084-13085	CD	denotes	5
T4412	13086-13094	NN	denotes	diphenyl
T4413	13085-13086	HYPH	denotes	-
T4414	13095-13106	NN	denotes	tetrazolium
T4415	13113-13114	-RRB-	denotes	)
T4416	13114-13115	HYPH	denotes	-
T4417	13121-13125	NNP	denotes	Cell
T4418	13126-13139	NNP	denotes	Proliferation
T4419	13144-13145	CD	denotes	I
T4420	13146-13147	-LRB-	denotes	(
T4421	13147-13152	NNP	denotes	Roche
T4422	13152-13153	-RRB-	denotes	)
T4423	13154-13163	VBG	denotes	according
T4424	13164-13166	IN	denotes	to
T4425	13167-13170	DT	denotes	the
T4426	13171-13183	NN	denotes	manufacturer
T4427	13186-13198	NNS	denotes	instructions
T4428	13183-13185	POS	denotes	's
T4429	13198-13199	.	denotes	.
T2932	7827-7829	NN	denotes	RT
T2933	7830-7833	NN	denotes	PCR
T2934	7829-7830	HYPH	denotes	–
T2935	7833-8032	sentence	denotes	All RT–PCRs were performed with QIAGEN® OneStep RT–PCR Kit (QIAGEN) according to the manufacturer's instructions, using 150–200 ng DNase I-digested total RNA (RNA isolation see microarray analysis).
T2936	7834-7837	DT	denotes	All
T2937	7841-7845	NNS	denotes	PCRs
T2938	7838-7840	NN	denotes	RT
T2939	7840-7841	HYPH	denotes	–
T2940	7851-7860	VBN	denotes	performed
T2941	7846-7850	VBD	denotes	were
T2942	7861-7865	IN	denotes	with
T2943	7866-7873	NNP	denotes	QIAGEN®
T2944	7889-7892	NN	denotes	Kit
T2945	7874-7881	NNP	denotes	OneStep
T2946	7882-7884	NN	denotes	RT
T2947	7885-7888	NN	denotes	PCR
T2948	7884-7885	HYPH	denotes	–
T2949	7893-7894	-LRB-	denotes	(
T2950	7894-7900	NNP	denotes	QIAGEN
T2951	7900-7901	-RRB-	denotes	)
T2952	7902-7911	VBG	denotes	according
T2953	7912-7914	IN	denotes	to
T2954	7915-7918	DT	denotes	the
T2955	7919-7931	NN	denotes	manufacturer
T2956	7934-7946	NNS	denotes	instructions
T2957	7931-7933	POS	denotes	's
T2958	7946-7948	,	denotes	,
T2959	7948-7953	VBG	denotes	using
T2960	7954-7957	CD	denotes	150
T2961	7958-7961	CD	denotes	200
T2962	7957-7958	SYM	denotes	–
T2963	7962-7964	NN	denotes	ng
T2964	7988-7991	NN	denotes	RNA
T2965	7965-7970	NN	denotes	DNase
T2966	7971-7972	NN	denotes	I
T2967	7973-7981	VBN	denotes	digested
T2968	7972-7973	HYPH	denotes	-
T2969	7982-7987	JJ	denotes	total
T2970	7992-7993	-LRB-	denotes	(
T2971	7997-8006	NN	denotes	isolation
T2972	7993-7996	NN	denotes	RNA
T2973	8007-8010	VBP	denotes	see
T2974	8011-8021	NN	denotes	microarray
T2975	8022-8030	NN	denotes	analysis
T2976	8030-8031	-RRB-	denotes	)
T2977	8031-8032	.	denotes	.
T2978	8032-8536	sentence	denotes	The reactions were carried out using the following primers: Csrp1: 5′-TTCCGATGTGCCAAGTGTGGC-3′; 5′-AGTAGAGAGTGGACATTCAGC-3′, hypoxanthin-guanin-phosphoribosyltransferase (Hprt): 5′-GCTGGTGAAAAGGACCTCTCG-3′; 5′-CCACAGGACTAGGACACCTGC-3′, Mtf1: 5′-GTGACTTTTGAGACTGTACTGAGTG-3′; 5′-CATGCCAAGAAACATTGAAGGTG-3′, Ndrg1: 5′-AGATACACAACAACGTGGAGG-3′; 5′-TGTGCGAGCGGCTTCGGGGGC-3′, Sepw1: 5′-TAGAGGCAGGGTCCTGAAAGC-3′; 5′-ACACCTGGAAACATGGCTGCC-3′, Slc39a10: 5′-GCTGTGGCTGGTAGTAAAAGC-3′; 5′-GTGGCATGGGATGTAAACAGC-3′.
T2979	8033-8036	DT	denotes	The
T2980	8037-8046	NNS	denotes	reactions
T2981	8052-8059	VBN	denotes	carried
T2982	8047-8051	VBD	denotes	were
T2983	8060-8063	RP	denotes	out
T2984	8064-8069	VBG	denotes	using
T2985	8070-8073	DT	denotes	the
T2986	8084-8091	NNS	denotes	primers
T2987	8074-8083	VBG	denotes	following
T2988	8091-8093	:	denotes	:
T2989	8093-8098	NN	denotes	Csrp1
T2990	8098-8100	:	denotes	:
T2991	8100-8101	CD	denotes	5
T2992	8101-8102	SYM	denotes	′
T2993	8102-8103	HYPH	denotes	-
T2994	8124-8125	HYPH	denotes	-
T2995	8125-8126	CD	denotes	3
T2996	8126-8127	SYM	denotes	′
T2997	8127-8128	:	denotes	;
T2998	8129-8130	CD	denotes	5
T2999	8132-8153	NN	denotes	AGTAGAGAGTGGACATTCAGC
T3000	8130-8131	SYM	denotes	′
T3001	8131-8132	HYPH	denotes	-
T3002	8153-8154	HYPH	denotes	-
T3003	8154-8155	CD	denotes	3
T3004	8155-8156	SYM	denotes	′
T3005	8156-8158	,	denotes	,
T3006	8158-8169	NN	denotes	hypoxanthin
T3007	8177-8202	NN	denotes	phosphoribosyltransferase
T3008	8169-8170	HYPH	denotes	-
T3009	8170-8176	NN	denotes	guanin
T3010	8176-8177	HYPH	denotes	-
T3011	8203-8204	-LRB-	denotes	(
T3012	8204-8208	NN	denotes	Hprt
T3013	8208-8209	-RRB-	denotes	)
T3014	8209-8211	:	denotes	:
T3015	8211-8212	CD	denotes	5
T3016	8214-8235	NN	denotes	GCTGGTGAAAAGGACCTCTCG
T3017	8212-8213	SYM	denotes	′
T3018	8213-8214	HYPH	denotes	-
T3019	8235-8236	HYPH	denotes	-
T3020	8236-8237	CD	denotes	3
T3021	8237-8238	SYM	denotes	′
T3022	8238-8239	:	denotes	;
T3023	8240-8241	CD	denotes	5
T3024	8243-8264	NN	denotes	CCACAGGACTAGGACACCTGC
T3027	8264-8265	HYPH	denotes	-
T3028	8265-8266	CD	denotes	3
T3029	8266-8267	SYM	denotes	′
T3030	8267-8269	,	denotes	,
T3031	8269-8273	NN	denotes	Mtf1
T3032	8273-8275	:	denotes	:
T3033	8275-8276	CD	denotes	5
T3034	8278-8303	NN	denotes	GTGACTTTTGAGACTGTACTGAGTG
T3035	8276-8277	SYM	denotes	′
T3036	8277-8278	HYPH	denotes	-
T3037	8303-8304	HYPH	denotes	-
T3038	8304-8305	CD	denotes	3
T3039	8305-8306	SYM	denotes	′
T3040	8306-8307	:	denotes	;
T3041	8308-8309	CD	denotes	5
T3042	8311-8334	NN	denotes	CATGCCAAGAAACATTGAAGGTG
T3043	8309-8310	SYM	denotes	′
T3044	8310-8311	HYPH	denotes	-
T3045	8334-8335	HYPH	denotes	-
T3046	8335-8336	CD	denotes	3
T3047	8336-8337	SYM	denotes	′
T3048	8337-8339	,	denotes	,
T2279	5509-5513	IN	denotes	from
T3049	8339-8344	NN	denotes	Ndrg1
T3050	8344-8346	:	denotes	:
T3051	8346-8347	CD	denotes	5
T3052	8349-8370	NN	denotes	AGATACACAACAACGTGGAGG
T3053	8347-8348	SYM	denotes	′
T2293	5576-5578	NN	denotes	pC
T3054	8348-8349	HYPH	denotes	-
T3055	8370-8371	HYPH	denotes	-
T3056	8371-8372	CD	denotes	3
T3057	8372-8373	SYM	denotes	′
T3058	8373-8374	:	denotes	;
T3059	8375-8376	CD	denotes	5
T3060	8378-8399	NN	denotes	TGTGCGAGCGGCTTCGGGGGC
T3061	8376-8377	SYM	denotes	′
T3062	8377-8378	HYPH	denotes	-
T3063	8399-8400	HYPH	denotes	-
T3064	8400-8401	CD	denotes	3
T3065	8401-8402	SYM	denotes	′
T3066	8402-8404	,	denotes	,
T3067	8404-8409	NN	denotes	Sepw1
T3068	8409-8411	:	denotes	:
T3069	8411-8412	CD	denotes	5
T3070	8414-8435	NN	denotes	TAGAGGCAGGGTCCTGAAAGC
T3071	8412-8413	SYM	denotes	′
T3072	8413-8414	HYPH	denotes	-
T3073	8435-8436	HYPH	denotes	-
T3074	8436-8437	CD	denotes	3
T3075	8437-8438	SYM	denotes	′
T3076	8438-8439	:	denotes	;
T3077	8440-8441	CD	denotes	5
T3078	8443-8464	NN	denotes	ACACCTGGAAACATGGCTGCC
T3079	8441-8442	SYM	denotes	′
T3080	8442-8443	HYPH	denotes	-
T3081	8464-8465	HYPH	denotes	-
T3082	8465-8466	CD	denotes	3
T3083	8466-8467	SYM	denotes	′
T3084	8467-8469	,	denotes	,
T3085	8469-8477	NN	denotes	Slc39a10
T3086	8477-8479	:	denotes	:
T3087	8479-8480	CD	denotes	5
T3088	8482-8503	NN	denotes	GCTGTGGCTGGTAGTAAAAGC
T3089	8480-8481	SYM	denotes	′
T3090	8481-8482	HYPH	denotes	-
T3091	8503-8504	HYPH	denotes	-
T3092	8504-8505	CD	denotes	3
T3093	8505-8506	SYM	denotes	′
T3094	8506-8507	:	denotes	;
T3095	8508-8509	CD	denotes	5
T3096	8511-8532	NN	denotes	GTGGCATGGGATGTAAACAGC
T3097	8509-8510	SYM	denotes	′
T3098	8510-8511	HYPH	denotes	-
T3099	8532-8533	HYPH	denotes	-
T3100	8533-8534	CD	denotes	3
T3101	8534-8535	SYM	denotes	′
T3102	8535-8536	.	denotes	.
T2173	5035-5041	NN	denotes	Animal
T2174	5042-5051	NN	denotes	treatment
T2175	5051-5449	sentence	denotes	At 8 weeks of age, male Mtf1loxP/loxP mice harboring the Mx-cre transgene (Mtf1loxP/loxP Mx-cre, abbr.: Mtf1Mx-cre) and control littermates without transgene (Mtf1loxP/loxP, abbr.: Mtf1loxP) received four intraperitoneal injections each of 300 µg synthetic double-stranded RNA polyinosinic–polycytidylic acid [pI–pC; Sigma; in a volume of 60 µl phosphate-buffered saline (PBS)] at 3 day intervals.
T2176	5052-5054	IN	denotes	At
T2177	5243-5251	VBD	denotes	received
T2178	5055-5056	CD	denotes	8
T2179	5057-5062	NNS	denotes	weeks
T2180	5063-5065	IN	denotes	of
T2181	5066-5069	NN	denotes	age
T2182	5069-5071	,	denotes	,
T2183	5071-5075	JJ	denotes	male
T2184	5090-5094	NNS	denotes	mice
T2185	5076-5084	NN	denotes	Mtf1loxP
T2186	5085-5089	NN	denotes	loxP
T2187	5084-5085	HYPH	denotes	/
T2188	5095-5104	VBG	denotes	harboring
T2189	5105-5108	DT	denotes	the
T2190	5116-5125	NN	denotes	transgene
T2191	5109-5111	NN	denotes	Mx
T2192	5112-5115	NN	denotes	cre
T2193	5111-5112	HYPH	denotes	-
T2194	5126-5127	-LRB-	denotes	(
T2195	5127-5135	NN	denotes	Mtf1loxP
T2196	5144-5147	NN	denotes	cre
T2197	5135-5136	HYPH	denotes	/
T2198	5136-5140	NN	denotes	loxP
T2199	5141-5143	NN	denotes	Mx
T2200	5143-5144	HYPH	denotes	-
T2201	5147-5149	,	denotes	,
T2202	5149-5154	RB	denotes	abbr.
T2203	5163-5166	NN	denotes	cre
T2204	5154-5156	:	denotes	:
T2205	5156-5162	NN	denotes	Mtf1Mx
T2206	5162-5163	HYPH	denotes	-
T2207	5166-5167	-RRB-	denotes	)
T2208	5168-5171	CC	denotes	and
T2209	5172-5179	NN	denotes	control
T2210	5180-5191	NNS	denotes	littermates
T2211	5192-5199	IN	denotes	without
T2212	5200-5209	NN	denotes	transgene
T2213	5210-5211	-LRB-	denotes	(
T2214	5211-5219	NN	denotes	Mtf1loxP
T2215	5220-5224	NN	denotes	loxP
T2216	5219-5220	HYPH	denotes	/
T2217	5224-5226	,	denotes	,
T2218	5226-5231	NN	denotes	abbr.
T2219	5233-5241	NN	denotes	Mtf1loxP
T2220	5231-5233	:	denotes	:
T2221	5241-5242	-RRB-	denotes	)
T2222	5252-5256	CD	denotes	four
T2223	5273-5283	NNS	denotes	injections
T2224	5257-5272	JJ	denotes	intraperitoneal
T2225	5284-5288	RB	denotes	each
T2226	5289-5291	IN	denotes	of
T2227	5292-5295	CD	denotes	300
T2228	5296-5298	NN	denotes	µg
T2229	5356-5360	NN	denotes	acid
T2230	5299-5308	JJ	denotes	synthetic
T2231	5309-5315	JJ	denotes	double
T2232	5316-5324	VBN	denotes	stranded
T2233	5723-5725	CD	denotes	20
T6934	21421-21422	HYPH	denotes	-
T2234	5315-5316	HYPH	denotes	-
T2235	5325-5328	NN	denotes	RNA
T2236	5329-5341	JJ	denotes	polyinosinic
T2237	5342-5355	JJ	denotes	polycytidylic
T6935	21533-21541	NN	denotes	proteins
T3873	11275-11283	NN	denotes	Mtf1loxP
T2238	5341-5342	HYPH	denotes	–
T2239	5361-5362	-LRB-	denotes	[
T2240	5369-5374	NNP	denotes	Sigma
T2241	5362-5364	NN	denotes	pI
T3874	11383-11395	NN	denotes	streptomycin
T2242	5365-5367	NN	denotes	pC
T2243	5364-5365	HYPH	denotes	–
T2244	5367-5368	:	denotes	;
T2245	5374-5375	:	denotes	;
T2246	5376-5378	IN	denotes	in
T2247	5379-5380	DT	denotes	a
T2248	5381-5387	NN	denotes	volume
T2249	5388-5390	IN	denotes	of
T2250	5391-5393	CD	denotes	60
T2251	5394-5396	NN	denotes	µl
T2252	5397-5406	NN	denotes	phosphate
T2253	5407-5415	VBN	denotes	buffered
T2254	5406-5407	HYPH	denotes	-
T2255	5416-5422	NN	denotes	saline
T2256	5423-5424	-LRB-	denotes	(
T2257	5424-5427	NN	denotes	PBS
T2258	5427-5428	-RRB-	denotes	)
T2259	5428-5429	-RRB-	denotes	]
T2260	5430-5432	IN	denotes	at
T2261	5433-5434	CD	denotes	3
T2262	5435-5438	NN	denotes	day
T2263	5439-5448	NNS	denotes	intervals
T2264	5448-5449	.	denotes	.
T2265	5449-5590	sentence	denotes	Only in the case of DNA-binding studies with MRE sequences from MTF-1 target gene candidates, the control mice received no pI–pC injections.
T2266	5450-5454	RB	denotes	Only
T2267	5455-5457	IN	denotes	in
T2268	5561-5569	VBD	denotes	received
T2269	5458-5461	DT	denotes	the
T2270	5462-5466	NN	denotes	case
T2271	5467-5469	IN	denotes	of
T2272	5470-5473	NN	denotes	DNA
T2273	5474-5481	VBG	denotes	binding
T2274	5473-5474	HYPH	denotes	-
T2275	5482-5489	NNS	denotes	studies
T2276	5490-5494	IN	denotes	with
T2277	5495-5498	NN	denotes	MRE
T2278	5499-5508	NNS	denotes	sequences
T2280	5514-5517	NN	denotes	MTF
T2281	5532-5542	NNS	denotes	candidates
T2282	5517-5518	HYPH	denotes	-
T2283	5518-5519	CD	denotes	1
T2284	5520-5526	NN	denotes	target
T2285	5527-5531	NN	denotes	gene
T2286	5542-5544	,	denotes	,
T2287	5544-5547	DT	denotes	the
T2288	5556-5560	NNS	denotes	mice
T2289	5548-5555	NN	denotes	control
T2290	5570-5572	DT	denotes	no
T2291	5579-5589	NNS	denotes	injections
T2292	5573-5575	NN	denotes	pI
T2294	5575-5576	HYPH	denotes	–
T2295	5589-5590	.	denotes	.
T2296	5590-5864	sentence	denotes	For experiments with metal treatment, mice received 2 days after the last pI–pC treatment a subcutaneous (s.c.) injection of either 20 µmol/kg body weight CdSO4 (2 mM CdSO4 in H2O; cadmium treatment) or 10 ml/kg body weight H2O (mock treatment) 6 h before sacrificing them.
T2297	5591-5594	IN	denotes	For
T2298	5634-5642	VBD	denotes	received
T2299	5595-5606	NNS	denotes	experiments
T2300	5607-5611	IN	denotes	with
T2301	5612-5617	NN	denotes	metal
T2302	5618-5627	NN	denotes	treatment
T2303	5627-5629	,	denotes	,
T2304	5629-5633	NNS	denotes	mice
T2305	5643-5644	CD	denotes	2
T2306	5645-5649	NNS	denotes	days
T2307	5650-5655	IN	denotes	after
T2308	5656-5659	DT	denotes	the
T2309	5671-5680	NN	denotes	treatment
T2310	5660-5664	JJ	denotes	last
T2311	5665-5667	NN	denotes	pI
T2312	5668-5670	NN	denotes	pC
T2313	5667-5668	HYPH	denotes	–
T2314	5681-5682	DT	denotes	a
T2315	5703-5712	NN	denotes	injection
T2316	5683-5695	JJ	denotes	subcutaneous
T2317	5697-5701	JJ	denotes	s.c.
T2318	5696-5697	-LRB-	denotes	(
T2319	5701-5702	-RRB-	denotes	)
T2320	5713-5715	IN	denotes	of
T2321	5716-5722	CC	denotes	either
T2322	5746-5751	NN	denotes	CdSO4
T2323	5726-5730	NN	denotes	µmol
T2324	5730-5731	SYM	denotes	/
T2325	5739-5745	NN	denotes	weight
T2326	5731-5733	NN	denotes	kg
T2327	5734-5738	NN	denotes	body
T2328	5752-5753	-LRB-	denotes	(
T2329	5780-5789	NN	denotes	treatment
T2330	5753-5754	CD	denotes	2
T2331	5755-5757	NN	denotes	mM
T2334	5767-5770	NN	denotes	H2O
T2332	5758-5763	NN	denotes	CdSO4
T2333	5764-5766	IN	denotes	in
T2335	5770-5771	:	denotes	;
T2336	5772-5779	NN	denotes	cadmium
T2337	5789-5790	-RRB-	denotes	)
T2338	5791-5793	CC	denotes	or
T2339	5794-5796	CD	denotes	10
T2340	5797-5799	NN	denotes	ml
T2341	5815-5818	NN	denotes	H2O
T2342	5799-5800	SYM	denotes	/
T2343	5808-5814	NN	denotes	weight
T2344	5800-5802	NN	denotes	kg
T2345	5803-5807	NN	denotes	body
T2346	5819-5820	-LRB-	denotes	(
T2347	5825-5834	NN	denotes	treatment
T2348	5820-5824	JJ	denotes	mock
T2349	5834-5835	-RRB-	denotes	)
T2350	5836-5837	CD	denotes	6
T2351	5838-5839	NN	denotes	h
T2352	5840-5846	IN	denotes	before
T2353	5847-5858	VBG	denotes	sacrificing
T2354	5859-5863	PRP	denotes	them
T2355	5863-5864	.	denotes	.
T6936	21280-21287	NN	denotes	Cadmium
T6937	21288-21296	NN	denotes	response
T6938	21306-21313	VBZ	denotes	depends
T6939	21297-21299	IN	denotes	of
T6940	21300-21305	NN	denotes	Csrp1
T6941	21314-21316	IN	denotes	on
T6942	21317-21320	NN	denotes	MTF
T6943	21320-21321	HYPH	denotes	-
T6944	21321-21322	CD	denotes	1
T6945	21322-21470	sentence	denotes	Csrp1 was found in microarray analyses to be significantly downregulated in cadmium-treated Mtf1Mx-cre mice compared to Mtf1loxP mice (Table 1, c).
T6946	21323-21328	NN	denotes	Csrp1
T6947	21333-21338	VBN	denotes	found
T6948	21329-21332	VBD	denotes	was
T6949	21339-21341	IN	denotes	in
T6950	21342-21352	NN	denotes	microarray
T6951	21353-21361	NNS	denotes	analyses
T6952	21362-21364	TO	denotes	to
T6953	21382-21395	VBN	denotes	downregulated
T6954	21365-21367	VB	denotes	be
T6955	21368-21381	RB	denotes	significantly
T6956	21396-21398	IN	denotes	in
T6957	21399-21406	NN	denotes	cadmium
T6958	21407-21414	VBN	denotes	treated
T6959	21406-21407	HYPH	denotes	-
T6960	21426-21430	NNS	denotes	mice
T6961	21415-21421	NN	denotes	Mtf1Mx
T6962	21422-21425	NN	denotes	cre
T6963	21431-21439	VBN	denotes	compared
T6964	21440-21442	IN	denotes	to
T6965	21443-21451	NN	denotes	Mtf1loxP
T6966	21452-21456	NNS	denotes	mice
T6967	21457-21458	-LRB-	denotes	(
T6968	21467-21468	NN	denotes	c
T6969	21458-21463	NN	denotes	Table
T6970	21464-21465	CD	denotes	1
T6971	21465-21467	,	denotes	,
T6972	21468-21469	-RRB-	denotes	)
T6973	21469-21470	.	denotes	.
T6974	21470-21618	sentence	denotes	CSRP1 is a member of the evolutionary conserved CRP family of proteins that have been implicated in myogenesis and cytoskeletal remodeling (41,42).
T6975	21471-21476	NN	denotes	CSRP1
T6976	21477-21479	VBZ	denotes	is
T6977	21480-21481	DT	denotes	a
T6978	21482-21488	NN	denotes	member
T6979	21489-21491	IN	denotes	of
T6980	21492-21495	DT	denotes	the
T6981	21523-21529	NN	denotes	family
T6982	21496-21508	JJ	denotes	evolutionary
T6983	21509-21518	VBN	denotes	conserved
T6984	21519-21522	NN	denotes	CRP
T6985	21530-21532	IN	denotes	of
T6986	21542-21546	WDT	denotes	that
T6987	21557-21567	VBN	denotes	implicated
T6988	21547-21551	VBP	denotes	have
T6989	21552-21556	VBN	denotes	been
T6990	21568-21570	IN	denotes	in
T6991	21571-21581	NN	denotes	myogenesis
T6992	21582-21585	CC	denotes	and
T6993	21586-21598	JJ	denotes	cytoskeletal
T6994	21599-21609	NN	denotes	remodeling
T6995	21610-21611	-LRB-	denotes	(
T6996	21614-21616	CD	denotes	42
T6997	21611-21613	CD	denotes	41
T6998	21613-21614	,	denotes	,
T6999	21616-21617	-RRB-	denotes	)
T7000	21617-21618	.	denotes	.
T7001	21618-21773	sentence	denotes	Semiquantitative RT–PCRs confirmed the microarray results, namely, that Csrp1 expression is elevated in Mtf1loxP livers upon cadmium exposure (Figure 4a).
T7002	21619-21635	JJ	denotes	Semiquantitative
T7003	21639-21643	NNS	denotes	PCRs
T7004	21636-21638	NN	denotes	RT
T7005	21638-21639	HYPH	denotes	–
T7006	21644-21653	VBD	denotes	confirmed
T7007	21654-21657	DT	denotes	the
T7008	21658-21668	NN	denotes	microarray
T7009	21669-21676	VBZ	denotes	results
T7010	21676-21678	,	denotes	,
T7011	21678-21684	RB	denotes	namely
T7012	21711-21719	VBN	denotes	elevated
T7013	21684-21686	,	denotes	,
T7014	21686-21690	IN	denotes	that
T7015	21691-21696	NN	denotes	Csrp1
T7016	21697-21707	NN	denotes	expression
T7017	21708-21710	VBZ	denotes	is
T7019	21723-21731	NN	denotes	Mtf1loxP
T7018	21720-21722	IN	denotes	in
T7020	21732-21738	NNS	denotes	livers
T7021	21739-21743	IN	denotes	upon
T7022	21744-21751	NN	denotes	cadmium
T7023	21752-21760	NN	denotes	exposure
T7024	21761-21762	-LRB-	denotes	(
T7025	21769-21771	NN	denotes	4a
T7026	21762-21768	NN	denotes	Figure
T7027	21771-21772	-RRB-	denotes	)
T7028	21772-21773	.	denotes	.
T7029	21773-21919	sentence	denotes	In contrast, no cadmium response was detectable in livers from Mtf1Mx-cre mice, suggesting that MTF-1 is required for cadmium induction of Csrp1.
T7030	21774-21776	IN	denotes	In
T7031	21807-21810	VBD	denotes	was
T7032	21777-21785	NN	denotes	contrast
T7033	21785-21787	,	denotes	,
T7034	21787-21789	DT	denotes	no
T7035	21798-21806	NN	denotes	response
T7036	21790-21797	NN	denotes	cadmium
T7037	21811-21821	JJ	denotes	detectable
T7038	21822-21824	IN	denotes	in
T7039	21825-21831	NNS	denotes	livers
T7040	21832-21836	IN	denotes	from
T7041	21837-21843	NN	denotes	Mtf1Mx
T7042	21844-21847	NN	denotes	cre
T7043	21843-21844	HYPH	denotes	-
T7044	21848-21852	NNS	denotes	mice
T7045	21852-21854	,	denotes	,
T7046	21854-21864	VBG	denotes	suggesting
T7047	21865-21869	IN	denotes	that
T7048	21879-21887	VBN	denotes	required
T7049	21870-21873	NN	denotes	MTF
T7050	21873-21874	HYPH	denotes	-
T7051	21874-21875	CD	denotes	1
T7053	21888-21891	IN	denotes	for
T7054	21892-21899	NN	denotes	cadmium
T7055	21900-21909	NN	denotes	induction
T7056	21910-21912	IN	denotes	of
T7057	21913-21918	NN	denotes	Csrp1
T7058	21918-21919	.	denotes	.
T7059	21919-22102	sentence	denotes	Three MRE core consensus sequences were found upstream of the Csrp1 transcription start (MRE2 to MRE4, −56 to −366 bp), one was found immediately downstream (MRE1, +7 bp; Figure 4b).
T7060	21920-21925	CD	denotes	Three
T7061	21945-21954	NNS	denotes	sequences
T7062	21926-21929	NN	denotes	MRE
T7063	21930-21934	NN	denotes	core
T7064	21935-21944	NN	denotes	consensus
T7065	21960-21965	VBN	denotes	found
T7066	21955-21959	VBD	denotes	were
T7067	22048-22053	VBN	denotes	found
T7068	21966-21974	RB	denotes	upstream
T7069	21975-21977	IN	denotes	of
T7070	21978-21981	DT	denotes	the
T7071	22002-22007	NN	denotes	start
T7072	21982-21987	NN	denotes	Csrp1
T7073	21988-22001	NN	denotes	transcription
T7074	22008-22009	-LRB-	denotes	(
T7075	22035-22037	NN	denotes	bp
T7085	22037-22038	-RRB-	denotes	)
T7102	22102-22337	sentence	denotes	Specific binding of MTF-1 was observed with EMSA for MRE2 oligonucleotide and protein extract from an Mtf1loxP liver, but not an Mtf1Mx-cre liver extract lacking MTF-1, confirming the participation of MTF-1 in the complex (Figure 4c).
T7076	22009-22013	NN	denotes	MRE2
T7077	22014-22016	IN	denotes	to
T7078	22017-22021	NN	denotes	MRE4
T7079	22021-22023	,	denotes	,
T7080	22023-22024	SYM	denotes	−
T7081	22024-22026	CD	denotes	56
T7082	22031-22034	CD	denotes	366
T7083	22027-22029	IN	denotes	to
T7084	22030-22031	SYM	denotes	−
T7086	22038-22040	,	denotes	,
T7087	22040-22043	CD	denotes	one
T7088	22044-22047	VBD	denotes	was
T7089	22054-22065	RB	denotes	immediately
T7090	22066-22076	RB	denotes	downstream
T7091	22077-22078	-LRB-	denotes	(
T7092	22098-22100	NN	denotes	4b
T7093	22078-22082	NN	denotes	MRE1
T7094	22082-22084	,	denotes	,
T7095	22084-22085	SYM	denotes	+
T7096	22085-22086	CD	denotes	7
T7097	22087-22089	NN	denotes	bp
T7098	22089-22090	:	denotes	;
T7099	22091-22097	NN	denotes	Figure
T7100	22100-22101	-RRB-	denotes	)
T7101	22101-22102	.	denotes	.
T7103	22103-22111	JJ	denotes	Specific
T7104	22112-22119	NN	denotes	binding
T7105	22133-22141	VBN	denotes	observed
T7106	22120-22122	IN	denotes	of
T7107	22123-22126	NN	denotes	MTF
T7108	22126-22127	HYPH	denotes	-
T7109	22127-22128	CD	denotes	1
T7110	22129-22132	VBD	denotes	was
T7111	22142-22146	IN	denotes	with
T7112	22147-22151	NN	denotes	EMSA
T7113	22152-22155	IN	denotes	for
T7114	22156-22160	NN	denotes	MRE2
T7115	22161-22176	NN	denotes	oligonucleotide
T7116	22177-22180	CC	denotes	and
T7117	22181-22188	NN	denotes	protein
T7118	22189-22196	NN	denotes	extract
T7119	22197-22201	IN	denotes	from
T7120	22202-22204	DT	denotes	an
T7121	22214-22219	NN	denotes	liver
T7122	22205-22213	NN	denotes	Mtf1loxP
T7123	22249-22256	NN	denotes	extract
T7124	22219-22221	,	denotes	,
T7125	22221-22224	CC	denotes	but
T7126	22225-22228	RB	denotes	not
T7127	22229-22231	DT	denotes	an
T7128	22243-22248	NN	denotes	liver
T7129	22232-22238	NN	denotes	Mtf1Mx
T7130	22239-22242	NN	denotes	cre
T7131	22238-22239	HYPH	denotes	-
T7132	22257-22264	VBG	denotes	lacking
T7133	22265-22268	NN	denotes	MTF
T7134	22268-22269	HYPH	denotes	-
T7135	22269-22270	CD	denotes	1
T7136	22270-22272	,	denotes	,
T7137	22272-22282	VBG	denotes	confirming
T7138	22283-22286	DT	denotes	the
T7139	22287-22300	NN	denotes	participation
T7140	22301-22303	IN	denotes	of
T7141	22304-22307	NN	denotes	MTF
T7142	22307-22308	HYPH	denotes	-
T7143	22308-22309	CD	denotes	1
T7144	22310-22312	IN	denotes	in
T7145	22313-22316	DT	denotes	the
T7146	22317-22324	NN	denotes	complex
T7147	22325-22326	-LRB-	denotes	(
T7148	22333-22335	NN	denotes	4c
T7149	22326-22332	NN	denotes	Figure
T7150	22335-22336	-RRB-	denotes	)
T7151	22336-22337	.	denotes	.
T3875	11198-11202	NN	denotes	Cell
T3876	11203-11210	NN	denotes	culture
T3877	11210-11441	sentence	denotes	Primary embryonic fibroblasts were isolated from a 12.5 day old Mtf1loxP mouse embryo and grown in DMEM supplemented with 10% fetal bovine serum (ICN), 100 U/ml penicillin–streptomycin (Gibco BRL) and 2 mM l-glutamine (Gibco BRL).
T3878	11211-11218	JJ	denotes	Primary
T3879	11229-11240	NNS	denotes	fibroblasts
T3880	11219-11228	JJ	denotes	embryonic
T3881	11246-11254	VBN	denotes	isolated
T3882	11241-11245	VBD	denotes	were
T3883	11255-11259	IN	denotes	from
T3884	11260-11261	DT	denotes	a
T3885	11267-11270	NN	denotes	day
T3886	11262-11266	CD	denotes	12.5
T3887	11271-11274	JJ	denotes	old
T3888	11290-11296	NN	denotes	embryo
T3889	11284-11289	NN	denotes	mouse
T3890	11297-11300	CC	denotes	and
T3891	11301-11306	VBN	denotes	grown
T3892	11307-11309	IN	denotes	in
T3893	11310-11314	NN	denotes	DMEM
T3894	11315-11327	VBN	denotes	supplemented
T3895	11328-11332	IN	denotes	with
T3896	11333-11335	CD	denotes	10
T3897	11335-11336	NN	denotes	%
T3898	11350-11355	NN	denotes	serum
T3899	11337-11342	JJ	denotes	fetal
T3900	11343-11349	JJ	denotes	bovine
T3901	11356-11357	-LRB-	denotes	(
T3902	11357-11360	NN	denotes	ICN
T3903	11360-11361	-RRB-	denotes	)
T3904	11361-11363	,	denotes	,
T3905	11363-11366	CD	denotes	100
T3906	11367-11368	NN	denotes	U
T3907	11368-11369	SYM	denotes	/
T3908	11369-11371	NN	denotes	ml
T3909	11372-11382	NN	denotes	penicillin
T3910	11382-11383	HYPH	denotes	–
T3911	11396-11397	-LRB-	denotes	(
T3912	11403-11406	NNP	denotes	BRL
T3913	11397-11402	NNP	denotes	Gibco
T3914	11406-11407	-RRB-	denotes	)
T3915	11408-11411	CC	denotes	and
T3916	11412-11413	CD	denotes	2
T3917	11414-11416	NN	denotes	mM
T3918	11419-11428	NN	denotes	glutamine
T3919	11417-11418	NN	denotes	l
T3920	11418-11419	HYPH	denotes	-
T3921	11429-11430	-LRB-	denotes	(
T3922	11436-11439	NNP	denotes	BRL
T3923	11430-11435	NNP	denotes	Gibco
T3924	11439-11440	-RRB-	denotes	)
T3925	11440-11441	.	denotes	.
T3926	11441-11711	sentence	denotes	100 mm plates with primary cells were transfected with 10 µg of an expression plasmid coding for simian virus 40 (SV40) large T antigen driven by the cytomegalovirus (CMV) promoter, using lipofectamine™ reagent (Invitrogen) according to the manufacturer's instructions.
T3927	11442-11445	CD	denotes	100
T3928	11446-11448	NN	denotes	mm
T3929	11449-11455	NNS	denotes	plates
T3930	11480-11491	VBN	denotes	transfected
T3931	11456-11460	IN	denotes	with
T3932	11461-11468	JJ	denotes	primary
T3933	11469-11474	NNS	denotes	cells
T3934	11475-11479	VBD	denotes	were
T3935	11492-11496	IN	denotes	with
T3936	11497-11499	CD	denotes	10
T3937	11500-11502	NN	denotes	µg
T3938	11503-11505	IN	denotes	of
T3939	11506-11508	DT	denotes	an
T3940	11520-11527	NN	denotes	plasmid
T3941	11509-11519	NN	denotes	expression
T3942	11528-11534	VBG	denotes	coding
T3943	11535-11538	IN	denotes	for
T3944	11539-11545	JJ	denotes	simian
T3945	11546-11551	NN	denotes	virus
T3946	11570-11577	NN	denotes	antigen
T3947	11552-11554	CD	denotes	40
T1954	4570-4779	sentence	denotes	Homozygous conditional knockout animals (Mtf1loxP/loxP) were crossed with the Cre recombinase transgenic line Mx-cre (a gift from Prof. Michel Aguet) to obtain an inducible, liver-specific Mtf1 knockout line.
T2075	4653-4664	NN	denotes	recombinase
T2076	4665-4675	JJ	denotes	transgenic
T2077	4681-4683	NN	denotes	Mx
T2078	4684-4687	NN	denotes	cre
T2079	4683-4684	HYPH	denotes	-
T2080	4688-4689	-LRB-	denotes	(
T2081	4691-4695	NN	denotes	gift
T2082	4689-4690	DT	denotes	a
T2083	4696-4700	IN	denotes	from
T2084	4701-4706	NNP	denotes	Prof.
T2085	4714-4719	NNP	denotes	Aguet
T2086	4707-4713	NNP	denotes	Michel
T2087	4719-4720	-RRB-	denotes	)
T2088	4721-4723	TO	denotes	to
T2089	4724-4730	VB	denotes	obtain
T2090	4731-4733	DT	denotes	an
T2091	4774-4778	NN	denotes	line
T2092	4734-4743	JJ	denotes	inducible
T2093	4743-4745	,	denotes	,
T2094	4745-4750	NN	denotes	liver
T2095	4751-4759	JJ	denotes	specific
T2096	4750-4751	HYPH	denotes	-
T2097	4760-4764	NN	denotes	Mtf1
T2098	4765-4773	NN	denotes	knockout
T2074	4649-4652	NN	denotes	Cre
T5425	15620-15627	RB	denotes	Thereby
T11581	36088-36099	NN	denotes	glutathione
T11582	36099-36101	,	denotes	,
T11583	36101-36105	IN	denotes	with
T11584	36106-36108	DT	denotes	an
T11585	36118-36125	NN	denotes	overlap
T11586	36109-36117	JJ	denotes	apparent
T11587	36126-36128	IN	denotes	in
T11588	36129-36134	NN	denotes	Sepw1
T11589	36134-36135	.	denotes	.
R337	T980	T981	det	All,organisms
R338	T981	T982	nsubj	organisms,evolved
R339	T983	T982	aux	have,evolved
R340	T984	T982	dobj	mechanisms,evolved
R341	T985	T986	aux	to,cope
R342	T986	T984	advcl	cope,mechanisms
R343	T987	T986	prep	with,cope
R344	T988	T989	det	a,variety
R345	T989	T987	pobj	variety,with
R346	T990	T989	prep	of,variety
R347	T991	T992	compound	stress,situations
R348	T992	T990	pobj	situations,of
R349	T993	T982	punct	.,evolved
R350	T995	T996	nummod	One,type
R351	T996	T997	nsubjpass	type,triggered
R352	T998	T996	prep	of,type
R353	T999	T1000	compound	stress,response
R354	T1000	T998	pobj	response,of
R355	T1001	T997	auxpass	is,triggered
R356	T1002	T997	agent	by,triggered
R357	T1003	T1004	amod	heavy,metals
R358	T1004	T1002	pobj	metals,by
R359	T1005	T1004	punct	", ",metals
R360	T1006	T1007	amod	such,as
R361	T1007	T1004	prep	as,metals
R362	T1008	T1007	pobj	zinc,as
R363	T1009	T1008	punct	", ",zinc
R364	T1010	T1008	conj	copper,zinc
R365	T1011	T1010	cc	and,copper
R366	T1012	T1010	conj	cadmium,copper
R367	T1013	T1014	punct	(,used
R368	T1014	T1002	parataxis	used,by
R369	T1015	T1014	prep	for,used
R370	T1016	T1015	pobj	convenience,for
R371	T1017	T1014	punct	", ",used
R372	T1018	T1019	det	the,zinc
R373	T1019	T1014	nsubjpass	zinc,used
R374	T1020	T1019	compound	terms,zinc
R375	T1021	T1019	punct	", ",zinc
R376	T1022	T1019	conj	copper,zinc
R377	T1023	T1022	cc	and,copper
R378	T1024	T1022	conj	cadmium,copper
R379	T1025	T1014	auxpass	are,used
R380	T1026	T1014	advmod	also,used
R381	T1027	T1014	advmod	here,used
R382	T1028	T1029	aux	to,denote
R383	T1029	T1014	advcl	denote,used
R384	T1030	T1029	dobj	Zn2,denote
R385	T1031	T1030	punct	+,Zn2
R386	T1032	T1030	punct	", ",Zn2
R387	T1033	T1030	conj	Cu2,Zn2
R388	T1034	T1033	punct	+,Cu2
R389	T1035	T1033	cc	and,Cu2
R390	T1036	T1033	conj	Cd2,Cu2
R391	T1037	T1036	punct	+,Cd2
R392	T1038	T1029	punct	", ",denote
R393	T1039	T1029	advmod	respectively,denote
R394	T1040	T1014	punct	),used
R395	T1041	T997	punct	.,triggered
R396	T1043	T1044	nsubj	Metallothioneins,play
R397	T1045	T1043	punct	(,Metallothioneins
R398	T1046	T1043	appos	MTs,Metallothioneins
R399	T1047	T1043	punct	),Metallothioneins
R400	T1048	T1043	punct	", ",Metallothioneins
R401	T1049	T1050	amod	small,proteins
R402	T1050	T1043	appos	proteins,Metallothioneins
R403	T1051	T1050	punct	", ",proteins
R404	T1052	T1053	npadvmod	cysteine,rich
R405	T1053	T1050	amod	rich,proteins
R406	T1054	T1053	punct	-,rich
R407	T1055	T1044	punct	", ",play
R408	T1056	T1057	det	an,role
R409	T1057	T1044	dobj	role,play
R410	T1058	T1057	amod	important,role
R411	T1059	T1044	prep	in,play
R412	T1060	T1061	compound	metal,homeostasis
R413	T1061	T1059	pobj	homeostasis,in
R414	T1062	T1061	cc	and,homeostasis
R415	T1063	T1061	conj	detoxification,homeostasis
R416	T1064	T1044	prep	due,play
R417	T1065	T1064	pcomp	to,due
R418	T1066	T1067	poss	their,ability
R419	T1067	T1064	pobj	ability,due
R420	T1068	T1069	aux	to,bind
R421	T1069	T1067	acl	bind,ability
R422	T1070	T1071	amod	different,ions
R423	T1071	T1069	dobj	ions,bind
R424	T1072	T1073	amod	heavy,metal
R425	T1073	T1071	compound	metal,ions
R426	T1074	T1075	punct	(,1
R427	T1075	T1067	parataxis	1,ability
R428	T1076	T1077	punct	–,3
R429	T1077	T1075	prep	3,1
R430	T1078	T1075	punct	),1
R431	T1079	T1044	punct	.,play
R432	T1081	T1082	prep	In,are
R433	T1083	T1084	det	the,mouse
R434	T1084	T1081	pobj	mouse,In
R435	T1085	T1082	punct	", ",are
R436	T1086	T1082	expl	there,are
R437	T1087	T1088	nummod	four,genes
R438	T1088	T1082	attr	genes,are
R439	T1089	T1088	compound	metallothionein,genes
R440	T1090	T1088	punct	", ",genes
R441	T1091	T1088	acl	designated,genes
R442	T1092	T1091	prep	as,designated
R443	T1093	T1092	pobj	Mt1,as
R444	T1094	T1093	prep	to,Mt1
R445	T1095	T1094	pobj	Mt4,to
R446	T1096	T1082	punct	.,are
R447	T1098	T1099	amod	Basal,expression
R448	T1099	T1109	nsubjpass	expression,mediated
R449	T1100	T1098	punct	", ",Basal
R450	T1101	T1102	advmod	as,as
R451	T1102	T1098	cc	as,Basal
R452	T1103	T1102	advmod	well,as
R453	T1104	T1105	amod	heavy,metal
R454	T1105	T1106	npadvmod	metal,induced
R455	T1106	T1098	conj	induced,Basal
R456	T1107	T1106	punct	-,induced
R457	T1108	T1099	punct	", ",expression
R458	T1110	T1099	prep	of,expression
R459	T1111	T1110	pobj	Mt1,of
R460	T1112	T1111	cc	and,Mt1
R461	T1113	T1111	conj	Mt2,Mt1
R462	T1114	T1109	auxpass	is,mediated
R463	T1115	T1109	agent	by,mediated
R464	T1116	T1117	npadvmod	metal,responsive
R465	T1117	T1119	amod	responsive,factor
R466	T1118	T1117	punct	-,responsive
R467	T1119	T1115	pobj	factor,by
R468	T1120	T1119	compound	transcription,factor
R469	T1121	T1119	nummod	1,factor
R470	T1122	T1119	punct	(,factor
R471	T1123	T1119	appos	MTF,factor
R472	T1124	T1123	punct	-,MTF
R473	T1125	T1123	nummod	1,MTF
R474	T1126	T1109	punct	),mediated
R475	T1127	T1128	punct	(,4
R476	T1128	T1109	parataxis	4,mediated
R477	T1129	T1130	punct	–,7
R478	T1130	T1128	prep	7,4
R479	T1131	T1128	punct	),4
R480	T1132	T1109	punct	.,mediated
R481	T1134	T1135	det	This,protein
R482	T1135	T1138	nsubj	protein,recognizes
R483	T1136	T1135	compound	zinc,protein
R484	T1137	T1135	compound	finger,protein
R485	T1139	T1140	amod	short,sequences
R486	T1140	T1138	dobj	sequences,recognizes
R487	T1141	T1142	npadvmod	cis,acting
R488	T1142	T1140	amod	acting,sequences
R489	T1143	T1142	punct	-,acting
R490	T1144	T1140	compound	DNA,sequences
R491	T1145	T1140	punct	", ",sequences
R492	T1146	T1140	acl	termed,sequences
R493	T1147	T1148	compound	metal,elements
R494	T1148	T1146	oprd	elements,termed
R495	T1149	T1148	compound	response,elements
R496	T1150	T1148	punct	(,elements
R497	T1151	T1148	appos	MREs,elements
R498	T1152	T1153	punct	;,TGCRCNC
R499	T1153	T1146	parataxis	TGCRCNC,termed
R500	T1154	T1153	compound	core,TGCRCNC
R501	T1155	T1153	compound	consensus,TGCRCNC
R502	T1156	T1153	compound	sequence,TGCRCNC
R503	T1157	T1153	punct	),TGCRCNC
R504	T1158	T1140	punct	", ",sequences
R505	T1159	T1160	dep	which,are
R506	T1160	T1140	relcl	are,sequences
R507	T1161	T1160	acomp	present,are
R508	T1162	T1160	prep	in,are
R509	T1163	T1164	det	the,promoters
R510	T1164	T1162	pobj	promoters,in
R511	T1165	T1164	prep	of,promoters
R512	T1166	T1167	compound	target,genes
R513	T1167	T1165	pobj	genes,of
R514	T1168	T1169	punct	(,9
R515	T1169	T1160	parataxis	9,are
R516	T1170	T1169	nummod	8,9
R517	T1171	T1169	punct	",",9
R518	T1172	T1169	punct	),9
R519	T1173	T1138	punct	.,recognizes
R520	T1175	T1176	nsubjpass	MTF,conserved
R521	T1177	T1175	punct	-,MTF
R522	T1178	T1175	nummod	1,MTF
R523	T1179	T1176	auxpass	is,conserved
R524	T1180	T1176	prep	in,conserved
R525	T1181	T1180	pobj	evolution,in
R526	T1182	T1176	punct	", ",conserved
R527	T1183	T1176	cc	and,conserved
R528	T1184	T1185	nsubjpass	homologs,characterized
R529	T1185	T1176	conj	characterized,conserved
R530	T1186	T1185	aux	have,characterized
R531	T1187	T1185	auxpass	been,characterized
R532	T1188	T1185	prep	in,characterized
R533	T1189	T1190	det	the,mouse
R534	T1190	T1188	pobj	mouse,in
R535	T1191	T1192	punct	(,10
R536	T1192	T1190	parataxis	10,mouse
R537	T1193	T1192	punct	),10
R538	T1194	T1190	punct	", ",mouse
R539	T1195	T1190	conj	humans,mouse
R540	T1196	T1197	punct	(,11
R541	T1197	T1195	parataxis	11,humans
R542	T1198	T1197	punct	),11
R543	T1199	T1195	punct	", ",humans
R544	T1200	T1195	conj	Drosophila,humans
R545	T1201	T1202	punct	(,12
R546	T1202	T1200	parataxis	12,Drosophila
R547	T1203	T1204	punct	–,14
R548	T1204	T1202	prep	14,12
R549	T1205	T1202	punct	),12
R550	T1206	T1200	cc	and,Drosophila
R551	T1207	T1200	conj	fish,Drosophila
R552	T1208	T1209	punct	(,16
R553	T1209	T1207	parataxis	16,fish
R554	T1210	T1209	nummod	15,16
R555	T1211	T1209	punct	",",16
R556	T1212	T1209	punct	),16
R557	T1213	T1185	punct	.,characterized
R558	T1215	T1216	det	The,role
R559	T1216	T1217	nsubjpass	role,studied
R560	T1218	T1216	prep	of,role
R561	T1219	T1218	pobj	MTF,of
R562	T1220	T1219	punct	-,MTF
R563	T1221	T1219	nummod	1,MTF
R564	T1222	T1217	aux	has,studied
R565	T1223	T1217	auxpass	been,studied
R566	T1224	T1225	advmod	most,extensively
R567	T1225	T1217	advmod	extensively,studied
R568	T1226	T1217	prep	in,studied
R569	T1227	T1228	det	the,mouse
R570	T1228	T1226	pobj	mouse,in
R571	T1229	T1217	punct	.,studied
R572	T1231	T1232	prep	Besides,mediate
R573	T1233	T1231	pcomp	coping,Besides
R574	T1234	T1233	prep	with,coping
R575	T1235	T1236	amod	heavy,metal
R576	T1236	T1237	compound	metal,load
R577	T1237	T1234	pobj	load,with
R578	T1238	T1232	punct	", ",mediate
R579	T1239	T1232	nsubj	MTF,mediate
R580	T1240	T1239	punct	-,MTF
R581	T1241	T1239	nummod	1,MTF
R582	T1242	T1232	aux	can,mediate
R583	T1243	T1232	advmod	also,mediate
R584	T1244	T1245	det	the,induction
R585	T1245	T1232	dobj	induction,mediate
R586	T1246	T1245	prep	of,induction
R587	T1247	T1248	compound	Mt,genes
R588	T1248	T1246	pobj	genes,of
R589	T1249	T1232	prep	in,mediate
R590	T1250	T1249	pobj	response,in
R591	T1251	T1250	prep	to,response
R592	T1252	T1253	amod	other,situations
R593	T1253	T1251	pobj	situations,to
R594	T1254	T1253	compound	stress,situations
R595	T1255	T1253	punct	", ",situations
R596	T1256	T1257	amod	such,as
R597	T1257	T1253	prep	as,situations
R598	T1258	T1259	amod	oxidative,stress
R599	T1259	T1257	pobj	stress,as
R600	T1260	T1261	punct	(,17
R601	T1261	T1259	parataxis	17,stress
R602	T1262	T1261	nummod	5,17
R603	T1263	T1261	punct	",",17
R604	T1264	T1261	punct	),17
R605	T1265	T1259	cc	and,stress
R606	T1266	T1259	conj	hypoxia,stress
R607	T1267	T1268	punct	(,18
R608	T1268	T1266	parataxis	18,hypoxia
R609	T1269	T1268	punct	),18
R610	T1270	T1232	punct	.,mediate
R611	T1272	T1273	prep	In,required
R612	T1274	T1272	pobj	addition,In
R613	T1275	T1273	punct	", ",required
R614	T1276	T1273	nsubjpass	it,required
R615	T1277	T1273	auxpass	is,required
R616	T1278	T1273	prep	for,required
R617	T1279	T1280	det	the,metalloregulation
R618	T1280	T1278	pobj	metalloregulation,for
R619	T1281	T1280	prep	of,metalloregulation
R620	T1282	T1281	pobj	Znt1,of
R621	T1283	T1273	punct	", ",required
R622	T1284	T1273	advcl	encoding,required
R623	T1285	T1286	det	the,transporter
R624	T1286	T1284	dobj	transporter,encoding
R625	T1287	T1286	amod	major,transporter
R626	T1288	T1289	compound	plasma,membrane
R627	T1289	T1290	npadvmod	membrane,localized
R628	T1290	T1286	amod	localized,transporter
R629	T1291	T1290	punct	-,localized
R630	T1292	T1293	compound	zinc,efflux
R631	T1293	T1286	compound	efflux,transporter
R632	T1294	T1295	punct	(,19
R633	T1295	T1286	parataxis	19,transporter
R634	T1296	T1295	punct	),19
R635	T1297	T1286	punct	", ",transporter
R636	T1298	T1299	det	the,induction
R637	T1299	T1286	appos	induction,transporter
R638	T1300	T1301	amod	hypoxic,anoxic
R639	T1301	T1299	amod	anoxic,induction
R640	T1302	T1301	punct	/,anoxic
R641	T1303	T1299	prep	of,induction
R642	T1304	T1305	det	the,gene
R643	T1305	T1303	pobj	gene,of
R644	T1306	T1305	prep	for,gene
R645	T1307	T1308	amod	placental,factor
R646	T1308	T1306	pobj	factor,for
R647	T1309	T1308	compound	growth,factor
R648	T1310	T1305	punct	(,gene
R649	T1311	T1305	appos	Plgf,gene
R650	T1312	T1286	punct	),transporter
R651	T1313	T1286	punct	", ",transporter
R652	T1314	T1315	det	an,protein
R653	T1315	T1286	appos	protein,transporter
R654	T1316	T1315	amod	angiogenic,protein
R655	T1317	T1315	prep	of,protein
R656	T1318	T1319	det	the,family
R657	T1319	T1317	pobj	family,of
R658	T1320	T1321	amod	vascular,factor
R659	T1321	T1319	nmod	factor,family
R660	T1322	T1321	amod	endothelial,factor
R661	T1323	T1321	nmod	growth,factor
R662	T1324	T1321	punct	(,factor
R663	T1325	T1321	appos	VEGF,factor
R664	T1326	T1319	punct	),family
R665	T1327	T1328	punct	(,20
R666	T1328	T1319	parataxis	20,family
R667	T1329	T1328	punct	),20
R668	T1330	T1273	punct	", ",required
R669	T1331	T1273	cc	and,required
R670	T1332	T1333	aux	has,invoked
R671	T1333	T1273	conj	invoked,required
R672	T1334	T1333	advmod	recently,invoked
R673	T1335	T1333	auxpass	been,invoked
R674	T1336	T1333	prep	in,invoked
R675	T1337	T1338	compound	tumor,development
R676	T1338	T1336	pobj	development,in
R677	T1339	T1340	punct	(,22
R678	T1340	T1333	parataxis	22,invoked
R679	T1341	T1340	nummod	21,22
R680	T1342	T1340	punct	",",22
R681	T1343	T1340	punct	),22
R682	T1344	T1273	punct	.,required
R683	T1346	T1347	advmod	Furthermore,has
R684	T1347	T1352	ccomp	has,results
R685	T1348	T1347	punct	", ",has
R686	T1349	T1347	nsubj	MTF,has
R687	T1350	T1349	punct	-,MTF
R688	T1351	T1349	nummod	1,MTF
R689	T1353	T1354	det	an,function
R690	T1354	T1347	dobj	function,has
R691	T1355	T1354	amod	essential,function
R692	T1356	T1347	prep	during,has
R693	T1357	T1356	pobj	embryogenesis,during
R694	T1358	T1352	punct	: ,results
R695	T1359	T1360	amod	targeted,disruption
R696	T1360	T1352	nsubj	disruption,results
R697	T1361	T1360	prep	of,disruption
R698	T1362	T1361	pobj	Mtf1,of
R699	T1363	T1352	prep	in,results
R700	T1364	T1365	amod	embryonic,lethality
R701	T1365	T1363	pobj	lethality,in
R702	T1366	T1352	prep	around,results
R703	T1367	T1368	nummod	14,days
R704	T1368	T1366	pobj	days,around
R705	T1369	T1370	advmod	post,coitum
R706	T1370	T1368	advmod	coitum,days
R707	T1371	T1352	prep	due,results
R708	T1372	T1371	pcomp	to,due
R709	T1373	T1374	compound	hepatocyte,necrosis
R710	T1374	T1371	pobj	necrosis,due
R711	T1375	T1376	punct	(,23
R712	T1376	T1352	parataxis	23,results
R713	T1377	T1376	punct	),23
R714	T1378	T1352	punct	.,results
R715	T1380	T1381	prep	In,are
R716	T1382	T1380	pobj	contrast,In
R717	T1383	T1381	punct	", ",are
R718	T1384	T1381	nsubj	mice,are
R719	T1385	T1384	prep	with,mice
R720	T1386	T1387	amod	null,mutations
R721	T1387	T1385	pobj	mutations,with
R722	T1388	T1387	prep	for,mutations
R723	T1389	T1390	det	the,genes
R724	T1390	T1388	pobj	genes,for
R725	T1391	T1392	npadvmod	stress,inducible
R726	T1392	T1390	amod	inducible,genes
R727	T1393	T1392	punct	-,inducible
R728	T1394	T1390	compound	metallothionein,genes
R729	T1395	T1390	punct	(,genes
R730	T1396	T1390	appos	Mt1,genes
R731	T1397	T1396	cc	and,Mt1
R732	T1398	T1396	conj	Mt2,Mt1
R733	T1399	T1381	punct	),are
R734	T1400	T1381	acomp	viable,are
R735	T1401	T1381	punct	", ",are
R736	T1402	T1403	mark	though,sensitive
R737	T1403	T1381	advcl	sensitive,are
R738	T1404	T1403	prep	to,sensitive
R739	T1405	T1404	pobj	cadmium,to
R740	T1406	T1407	punct	(,25
R741	T1407	T1403	parataxis	25,sensitive
R742	T1408	T1407	nummod	24,25
R743	T1409	T1407	punct	",",25
R744	T1410	T1407	punct	),25
R745	T1411	T1381	punct	", ",are
R746	T1412	T1381	advcl	indicating,are
R747	T1413	T1414	mark	that,involved
R748	T1414	T1412	ccomp	involved,indicating
R749	T1415	T1416	amod	additional,genes
R750	T1416	T1414	nsubjpass	genes,involved
R751	T1417	T1416	amod	important,genes
R752	T1418	T1416	nmod	MTF,genes
R753	T1419	T1418	punct	-,MTF
R754	T1420	T1418	nummod	1,MTF
R755	T1421	T1416	compound	target,genes
R756	T1422	T1414	auxpass	are,involved
R757	T1423	T1414	prep	in,involved
R758	T1424	T1425	det	the,phenotype
R759	T1425	T1423	pobj	phenotype,in
R760	T1426	T1425	amod	lethal,phenotype
R761	T1427	T1381	punct	.,are
R762	T1429	T1430	prep	With,is
R763	T1431	T1432	det	the,technique
R764	T1432	T1429	pobj	technique,With
R765	T1433	T1434	nmod	Cre,loxP
R766	T1434	T1432	nmod	loxP,technique
R767	T1435	T1434	punct	-,loxP
R768	T1436	T1437	amod	conditional,knockout
R769	T1437	T1432	compound	knockout,technique
R770	T1438	T1430	punct	", ",is
R771	T1439	T1430	nsubj	it,is
R772	T1440	T1430	acomp	possible,is
R773	T1441	T1442	aux	to,circumvent
R774	T1442	T1430	xcomp	circumvent,is
R775	T1443	T1444	det	the,phenotype
R776	T1444	T1442	dobj	phenotype,circumvent
R777	T1445	T1446	amod	embryonic,lethal
R778	T1446	T1444	amod	lethal,phenotype
R779	T1447	T1444	prep	of,phenotype
R780	T1448	T1449	amod	conventional,mice
R781	T1449	T1447	pobj	mice,of
R782	T1450	T1451	compound	Mtf1,knockout
R783	T1451	T1449	compound	knockout,mice
R784	T1452	T1430	punct	.,is
R785	T1454	T1455	amod	Previous,experiments
R786	T1455	T1456	nsubj	experiments,revealed
R787	T1457	T1455	prep	with,experiments
R788	T1458	T1459	det	this,technique
R789	T1459	T1457	pobj	technique,with
R790	T1460	T1461	mark	that,is
R791	T1461	T1456	ccomp	is,revealed
R792	T1462	T1461	nsubj	deletion,is
R793	T1463	T1462	prep	of,deletion
R794	T1464	T1463	pobj	Mtf1,of
R795	T1465	T1462	prep	from,deletion
R796	T1466	T1467	det	the,liver
R797	T1467	T1465	pobj	liver,from
R798	T1468	T1462	prep	after,deletion
R799	T1469	T1468	pobj	birth,after
R800	T1470	T1471	neg	no,longer
R801	T1471	T1461	advmod	longer,is
R802	T1472	T1461	acomp	lethal,is
R803	T1473	T1461	prep	under,is
R804	T1474	T1475	amod	non-stress,conditions
R805	T1475	T1473	pobj	conditions,under
R806	T1476	T1477	punct	(,26
R807	T1477	T1461	parataxis	26,is
R808	T1478	T1477	punct	),26
R809	T1479	T1456	punct	.,revealed
R810	T1481	T1482	prep	For,generated
R811	T1483	T1484	det	this,study
R812	T1484	T1481	pobj	study,For
R813	T1485	T1482	punct	", ",generated
R814	T1486	T1487	det	an,line
R815	T1487	T1482	nsubjpass	line,generated
R816	T1488	T1487	amod	inducible,line
R817	T1489	T1487	punct	", ",line
R818	T1490	T1491	npadvmod	liver,specific
R819	T1491	T1487	amod	specific,line
R820	T1492	T1491	punct	-,specific
R821	T1493	T1494	compound	Mtf1,knockout
R822	T1494	T1487	compound	knockout,line
R823	T1495	T1487	compound	mouse,line
R824	T1496	T1482	auxpass	was,generated
R825	T1497	T1498	aux	to,perform
R826	T1498	T1482	advcl	perform,generated
R827	T1499	T1500	det	a,search
R828	T1500	T1498	dobj	search,perform
R829	T1501	T1500	prep	for,search
R830	T1502	T1503	nmod	MTF,genes
R831	T1503	T1501	pobj	genes,for
R832	T1504	T1502	punct	-,MTF
R833	T1505	T1502	nummod	1,MTF
R834	T1506	T1503	compound	target,genes
R835	T1507	T1503	cc	and,genes
R836	T1508	T1509	npadvmod	cadmium,inducible
R837	T1509	T1511	amod	inducible,genes
R838	T1510	T1509	punct	-,inducible
R839	T1511	T1503	conj	genes,genes
R840	T1512	T1498	prep	in,perform
R841	T1513	T1514	det	the,liver
R842	T1514	T1512	pobj	liver,in
R843	T1515	T1514	amod	adult,liver
R844	T1516	T1482	punct	.,generated
R845	T1518	T1519	det	A,number
R846	T1519	T1520	nsubj	number,emerged
R847	T1521	T1519	prep	of,number
R848	T1522	T1523	compound	target,gene
R849	T1523	T1524	compound	gene,candidates
R850	T1524	T1521	pobj	candidates,of
R851	T1525	T1520	prep	upon,emerged
R852	T1526	T1527	det	a,analysis
R853	T1527	T1525	pobj	analysis,upon
R854	T1528	T1527	compound	transcriptome,analysis
R855	T1529	T1527	prep	of,analysis
R856	T1530	T1531	amod	mock,treated
R857	T1531	T1536	amod	treated,mice
R858	T1532	T1530	punct	-,mock
R859	T1533	T1530	cc	and,mock
R860	T1534	T1530	conj	cadmium,mock
R861	T1535	T1531	punct	-,treated
R862	T1536	T1529	pobj	mice,of
R863	T1537	T1536	nmod	Mtf1,mice
R864	T1538	T1539	amod	conditional,knockout
R865	T1539	T1536	compound	knockout,mice
R866	T1540	T1536	cc	and,mice
R867	T1541	T1542	compound	control,littermates
R868	T1542	T1536	conj	littermates,mice
R869	T1543	T1520	cc	and,emerged
R870	T1544	T1545	nsubjpass	several,confirmed
R871	T1545	T1520	conj	confirmed,emerged
R872	T1546	T1544	prep	of,several
R873	T1547	T1546	pobj	these,of
R874	T1548	T1545	auxpass	were,confirmed
R875	T1549	T1545	agent	by,confirmed
R876	T1550	T1551	amod	semiquantitative,PCR
R877	T1551	T1549	pobj	PCR,by
R878	T1552	T1551	compound	RT,PCR
R879	T1553	T1551	punct	–,PCR
R880	T1554	T1545	punct	.,confirmed
R881	T1556	T1557	prep	Besides,find
R882	T1558	T1559	det	the,genes
R883	T1559	T1556	pobj	genes,Besides
R884	T1560	T1561	npadvmod	stress,inducible
R885	T1561	T1559	amod	inducible,genes
R886	T1562	T1561	punct	-,inducible
R887	T1563	T1559	compound	metallothionein,genes
R888	T1564	T1565	dep	that,known
R889	T1565	T1559	relcl	known,genes
R890	T1566	T1565	auxpass	were,known
R891	T1567	T1565	advmod	already,known
R892	T1568	T1565	prep	as,known
R893	T1569	T1570	compound	target,genes
R894	T1570	T1568	pobj	genes,as
R895	T1571	T1570	prep	of,genes
R896	T1572	T1571	pobj	MTF,of
R897	T1573	T1572	punct	-,MTF
R898	T1574	T1572	nummod	1,MTF
R899	T1575	T1557	punct	", ",find
R900	T1576	T1557	nsubj	we,find
R901	T1577	T1578	mark	that,is
R902	T1578	T1557	ccomp	is,find
R903	T1579	T1578	nsubj	MTF,is
R904	T1580	T1579	punct	-,MTF
R905	T1581	T1579	nummod	1,MTF
R906	T1582	T1578	acomp	important,is
R907	T1583	T1582	prep	for,important
R908	T1584	T1585	amod	basal,expression
R909	T1585	T1583	pobj	expression,for
R910	T1586	T1585	compound	liver,expression
R911	T1587	T1585	prep	of,expression
R912	T1588	T1589	det	the,gene
R913	T1589	T1587	pobj	gene,of
R914	T1590	T1589	prep	for,gene
R915	T1591	T1592	nmod	selenoprotein,muscle
R916	T1592	T1590	pobj	muscle,for
R917	T1593	T1592	nmod	W,muscle
R918	T1594	T1592	punct	", ",muscle
R919	T1595	T1592	nummod	1,muscle
R920	T1596	T1592	punct	(,muscle
R921	T1597	T1592	appos	Sepw1,muscle
R922	T1598	T1590	punct	),for
R923	T1599	T1600	advmod	as,as
R924	T1600	T1590	cc	as,for
R925	T1601	T1600	advmod	well,as
R926	T1602	T1590	conj	for,for
R927	T1603	T1604	npadvmod	cadmium,induced
R928	T1604	T1606	amod	induced,expression
R929	T1605	T1604	punct	-,induced
R930	T1606	T1602	pobj	expression,for
R931	T1607	T1606	prep	of,expression
R932	T1608	T1609	nmod	N,myc
R933	T1609	T1611	nmod	myc,gene
R934	T1610	T1609	punct	-,myc
R935	T1611	T1607	pobj	gene,of
R936	T1612	T1613	advmod	downstream,regulated
R937	T1613	T1611	amod	regulated,gene
R938	T1614	T1611	nummod	1,gene
R939	T1615	T1611	punct	(,gene
R940	T1616	T1611	appos	Ndrg1,gene
R941	T1617	T1611	punct	),gene
R942	T1618	T1611	cc	and,gene
R943	T1619	T1620	det	the,gene
R944	T1620	T1611	conj	gene,gene
R945	T1621	T1620	acl	encoding,gene
R946	T1622	T1623	npadvmod	cysteine,rich
R947	T1623	T1628	amod	rich,protein
R948	T1624	T1622	punct	-,cysteine
R949	T1625	T1622	cc	and,cysteine
R950	T1626	T1622	conj	glycine,cysteine
R951	T1627	T1623	punct	-,rich
R952	T1628	T1621	dobj	protein,encoding
R953	T1629	T1628	nummod	1,protein
R954	T1630	T1628	punct	(,protein
R955	T1631	T1628	appos	Csrp1,protein
R956	T1632	T1557	punct	),find
R957	T1633	T1557	punct	.,find
R958	T1635	T1636	prep	In,appears
R959	T1637	T1635	pobj	addition,In
R960	T1638	T1636	punct	", ",appears
R961	T1639	T1636	nsubj	MTF,appears
R962	T1640	T1639	punct	-,MTF
R963	T1641	T1639	nummod	1,MTF
R964	T1642	T1643	aux	to,repress
R965	T1643	T1636	xcomp	repress,appears
R966	T1644	T1645	det	the,expression
R967	T1645	T1643	dobj	expression,repress
R968	T1646	T1645	prep	of,expression
R969	T1647	T1648	nmod	solute,member
R970	T1648	T1653	nmod	member,gene
R971	T1649	T1648	nmod	carrier,member
R972	T1650	T1648	nmod	family,member
R973	T1651	T1648	nummod	39,member
R974	T1652	T1648	punct	", ",member
R975	T1653	T1646	pobj	gene,of
R976	T1654	T1648	nummod	10,member
R977	T1655	T1653	punct	(,gene
R978	T1656	T1653	appos	Slc39a10,gene
R979	T1657	T1653	punct	),gene
R980	T1658	T1653	punct	", ",gene
R981	T1659	T1660	dep	which,encodes
R982	T1660	T1653	relcl	encodes,gene
R983	T1661	T1662	det	a,transporter
R984	T1662	T1660	dobj	transporter,encodes
R985	T1663	T1662	amod	putative,transporter
R986	T1664	T1665	compound	metal,ion
R987	T1665	T1662	compound	ion,transporter
R988	T1666	T1636	punct	.,appears
R989	T1668	T1669	prep	In,induced
R990	T1670	T1671	det	an,response
R992	T1672	T1673	npadvmod	MTF,independent
R993	T1673	T1671	amod	independent,response
R994	T1674	T1672	punct	-,MTF
R995	T1675	T1672	nummod	1,MTF
R996	T1676	T1673	punct	-,independent
R997	T1677	T1671	compound	transcriptome,response
R998	T1678	T1669	punct	", ",induced
R999	T1679	T1680	amod	several,genes
R1000	T1680	T1669	nsubjpass	genes,induced
R1001	T1681	T1680	acl	involved,genes
R1002	T1682	T1681	prep	in,involved
R1003	T1683	T1684	compound	glutathione,metabolism
R1004	T1684	T1682	pobj	metabolism,in
R1005	T1685	T1669	auxpass	are,induced
R1006	T1686	T1669	punct	.,induced
R1007	T1688	T1689	amod	Further,studies
R1008	T1689	T1690	nsubj	studies,confirmed
R1009	T1691	T1692	det	a,defense
R1010	T1692	T1690	dobj	defense,confirmed
R1011	T1693	T1692	amod	dual,defense
R1012	T1694	T1692	amod	anti-cadmium,defense
R1013	T1695	T1692	punct	", ",defense
R1014	T1696	T1692	appos	one,defense
R1015	T1697	T1696	prep	via,one
R1016	T1698	T1697	pobj	glutathione,via
R1017	T1699	T1696	cc	and,one
R1018	T1700	T1701	det	another,one
R1019	T1701	T1696	conj	one,one
R1020	T1702	T1701	prep	via,one
R1021	T1703	T1702	pobj	MTF,via
R1022	T1704	T1703	punct	-,MTF
R1023	T1705	T1703	nummod	1,MTF
R1024	T1706	T1703	cc	and,MTF
R1025	T1707	T1708	poss	its,genes
R1026	T1708	T1703	conj	genes,MTF
R1027	T1709	T1708	compound	target,genes
R1028	T1712	T1711	pobj	metallothioneins,including
R1029	T1710	T1708	punct	", ",genes
R1030	T1713	T1690	punct	.,confirmed
R1031	T1711	T1708	prep	including,genes
R1032	T1759	T1758	prep	of,Generation
R1033	T1760	T1761	nmod	Mtf1,mice
R1034	T1761	T1759	pobj	mice,of
R1035	T1762	T1763	amod	conditional,knockout
R1036	T1763	T1761	compound	knockout,mice
R1037	T1764	T1761	cc	and,mice
R1038	T1765	T1766	npadvmod	liver,specific
R1039	T1766	T1768	amod	specific,deletion
R1040	T1767	T1766	punct	-,specific
R1041	T1768	T1761	conj	deletion,mice
R1042	T1770	T1771	nmod	Mtf1,mice
R1043	T1771	T1774	nsubjpass	mice,generated
R1044	T1772	T1773	amod	conditional,knockout
R1045	T1773	T1771	compound	knockout,mice
R1046	T1775	T1774	auxpass	were,generated
R1047	T1776	T1774	prep	in,generated
R1048	T1777	T1776	pobj	collaboration,in
R1049	T1778	T1777	prep	with,collaboration
R1050	T1779	T1780	compound	Dr,Leviten
R1051	T1780	T1778	pobj	Leviten,with
R1052	T1781	T1780	compound	Michael,Leviten
R1053	T1782	T1783	punct	(,Carlos
R1054	T1783	T1780	parataxis	Carlos,Leviten
R1055	T1784	T1783	compound	San,Carlos
R1056	T1785	T1783	punct	", ",Carlos
R1057	T1786	T1783	npadvmod	CA,Carlos
R1058	T1787	T1783	punct	),Carlos
R1059	T1788	T1774	punct	.,generated
R1060	T1790	T1791	nummod	Two,clones
R1061	T1791	T1793	nsubjpass	clones,used
R1062	T1792	T1791	amod	genomic,clones
R1063	T1794	T1791	acl	containing,clones
R1064	T1795	T1796	nmod	exons,3
R1065	T1796	T1794	dobj	3,containing
R1066	T1797	T1796	prep	to,3
R1067	T1798	T1797	pobj	6,to
R1068	T1799	T1796	prep	of,3
R1069	T1800	T1799	pobj	Mtf1,of
R1070	T1801	T1793	auxpass	were,used
R1071	T1802	T1803	aux	to,construct
R1072	T1803	T1793	advcl	construct,used
R1073	T1804	T1805	det	a,vector
R1074	T1805	T1803	dobj	vector,construct
R1075	T1806	T1807	compound	gene,targeting
R1076	T1807	T1805	compound	targeting,vector
R1077	T1808	T1803	prep	for,construct
R1078	T1809	T1810	amod	homologous,recombination
R1079	T1810	T1808	pobj	recombination,for
R1080	T1811	T1812	punct	(,Data
R1081	T1812	T1803	parataxis	Data,construct
R1082	T1813	T1812	amod	Supplementary,Data
R1083	T1814	T1812	punct	),Data
R1084	T1815	T1793	punct	.,used
R1085	T1817	T1818	det	A,cassette
R1086	T1818	T1821	nsubjpass	cassette,cloned
R1087	T1819	T1818	compound	neomycin,cassette
R1088	T1820	T1818	compound	resistance,cassette
R1089	T1821	T1833	ccomp	cloned,cloned
R1090	T1822	T1818	punct	(,cassette
R1091	T1823	T1824	compound	PGK,neo
R1092	T1824	T1818	appos	neo,cassette
R1093	T1825	T1824	punct	-,neo
R1094	T1826	T1818	punct	),cassette
R1095	T1827	T1818	acl	flanked,cassette
R1096	T1828	T1827	agent	by,flanked
R1097	T1829	T1830	nummod	two,sites
R1098	T1830	T1828	pobj	sites,by
R1099	T1831	T1830	compound	loxP,sites
R1100	T1832	T1821	auxpass	was,cloned
R1101	T1834	T1821	prep	into,cloned
R1102	T1835	T1836	det	the,site
R1103	T1836	T1834	pobj	site,into
R1104	T1837	T1836	compound	SacI,site
R1105	T1838	T1836	npadvmod	5,site
R1106	T1839	T1838	punct	′,5
R1107	T1840	T1838	prep	of,5
R1108	T1841	T1840	pobj	exon,of
R1109	T1842	T1841	nummod	3,exon
R1110	T1843	T1841	prep	of,exon
R1111	T1844	T1843	pobj	Mtf1,of
R1112	T1845	T1833	punct	", ",cloned
R1113	T1846	T1847	det	the,site
R1114	T1847	T1833	nsubjpass	site,cloned
R1115	T1848	T1847	amod	third,site
R1116	T1849	T1847	compound	loxP,site
R1117	T1850	T1833	auxpass	was,cloned
R1118	T1851	T1833	prep	into,cloned
R1119	T1852	T1853	det	the,site
R1120	T1853	T1851	pobj	site,into
R1121	T1854	T1853	compound	ScaI,site
R1122	T1855	T1853	npadvmod	3,site
R1123	T1856	T1855	punct	′,3
R1124	T1857	T1855	prep	of,3
R1125	T1858	T1857	pobj	exon,of
R1126	T1859	T1858	nummod	4,exon
R1127	T1860	T1833	punct	.,cloned
R1128	T1862	T1863	det	A,cassette
R1129	T1863	T1869	nsubjpass	cassette,inserted
R1130	T1864	T1865	nmod	thymidine,kinase
R1131	T1865	T1863	nmod	kinase,cassette
R1132	T1866	T1865	punct	(,kinase
R1133	T1867	T1865	appos	TK,kinase
R1134	T1868	T1863	punct	),cassette
R1135	T1870	T1869	auxpass	was,inserted
R1136	T1871	T1869	prep	in,inserted
R1137	T1872	T1873	det	the,site
R1138	T1873	T1871	pobj	site,in
R1139	T1874	T1873	compound	HpaI,site
R1140	T1875	T1873	npadvmod	3,site
R1141	T1876	T1875	punct	′,3
R1142	T1877	T1875	prep	of,3
R1143	T1878	T1877	pobj	exon,of
R1144	T1879	T1878	nummod	6,exon
R1145	T1880	T1869	punct	.,inserted
R1146	T1882	T1883	nummod	129,cells
R1147	T1883	T1885	nsubjpass	cells,electroporated
R1148	T1884	T1883	compound	ES,cells
R1149	T1886	T1885	auxpass	were,electroporated
R1150	T1887	T1885	prep	with,electroporated
R1151	T1888	T1889	det	the,vector
R1152	T1889	T1887	pobj	vector,with
R1153	T1890	T1889	amod	linearized,vector
R1154	T1891	T1889	compound	targeting,vector
R1155	T1892	T1889	punct	", ",vector
R1156	T1893	T1889	acl	selected,vector
R1157	T1894	T1893	prep	in,selected
R1158	T1895	T1896	det	the,presence
R1159	T1896	T1894	pobj	presence,in
R1160	T1897	T1896	prep	of,presence
R1161	T1898	T1897	pobj	G418,of
R1162	T1899	T1898	cc	and,G418
R1163	T1900	T1898	conj	FIAU,G418
R1164	T1901	T1885	punct	", ",electroporated
R1165	T1902	T1885	cc	and,electroporated
R1166	T1903	T1885	conj	screened,electroporated
R1167	T1904	T1903	prep	for,screened
R1168	T1905	T1906	amod	correct,events
R1169	T1906	T1904	pobj	events,for
R1170	T1907	T1906	compound	integration,events
R1171	T1908	T1903	prep	by,screened
R1172	T1909	T1910	nmod	PCR,analysis
R1173	T1910	T1908	pobj	analysis,by
R1174	T1911	T1909	cc	and,PCR
R1175	T1912	T1913	compound	Southern,blot
R1176	T1913	T1909	conj	blot,PCR
R1177	T1914	T1885	punct	.,electroporated
R1178	T1916	T1917	amod	Transient,expression
R1179	T1917	T1918	nsubj	expression,led
R1180	T1919	T1917	prep	of,expression
R1181	T1920	T1921	compound	Cre,recombinase
R1182	T1921	T1919	pobj	recombinase,of
R1183	T1922	T1918	prep	to,led
R1184	T1923	T1922	pobj	removal,to
R1185	T1924	T1923	prep	of,removal
R1186	T1925	T1926	det	the,cassette
R1187	T1926	T1924	pobj	cassette,of
R1188	T1927	T1928	compound	PGK,neo
R1189	T1928	T1926	compound	neo,cassette
R1190	T1929	T1928	punct	-,neo
R1191	T1930	T1918	punct	", ",led
R1192	T1931	T1918	cc	and,led
R1193	T1932	T1933	nsubjpass	mice,generated
R1194	T1933	T1918	conj	generated,led
R1195	T1934	T1932	acl	carrying,mice
R1196	T1935	T1936	det	the,allele
R1197	T1936	T1934	dobj	allele,carrying
R1198	T1937	T1936	amod	modified,allele
R1199	T1938	T1936	compound	Mtf1loxP,allele
R1200	T1939	T1933	auxpass	were,generated
R1201	T1940	T1933	prep	by,generated
R1202	T1941	T1940	pobj	injection,by
R1203	T1942	T1941	prep	of,injection
R1204	T1943	T1944	amod	positive,clones
R1205	T1944	T1942	pobj	clones,of
R1206	T1945	T1941	prep	into,injection
R1207	T1946	T1947	nmod	C57Bl,blastocysts
R1208	T1947	T1945	pobj	blastocysts,into
R1209	T1948	T1946	punct	/,C57Bl
R1210	T1949	T1946	nummod	6,C57Bl
R1211	T1950	T1947	cc	and,blastocysts
R1212	T1951	T1952	amod	subsequent,crosses
R1213	T1952	T1947	conj	crosses,blastocysts
R1214	T1953	T1933	punct	.,generated
R1215	T1955	T1956	amod	Homozygous,animals
R1216	T1956	T1959	nsubjpass	animals,crossed
R1217	T1957	T1958	amod	conditional,knockout
R1218	T1958	T1956	compound	knockout,animals
R1219	T1960	T1956	punct	(,animals
R1220	T1961	T1962	compound	Mtf1loxP,loxP
R1221	T1962	T1956	appos	loxP,animals
R1222	T1963	T1962	punct	/,loxP
R1223	T1964	T1959	punct	),crossed
R1224	T1965	T1959	auxpass	were,crossed
R1225	T1966	T1959	prep	with,crossed
R1226	T1967	T1968	det	the,line
R1227	T1968	T1966	pobj	line,with
R1228	T2074	T2075	compound	Cre,recombinase
R1229	T2075	T2076	npadvmod	recombinase,transgenic
R1230	T2076	T1968	amod	transgenic,line
R1231	T2077	T2078	compound	Mx,cre
R1232	T2078	T1968	appos	cre,line
R1233	T2079	T2078	punct	-,cre
R1234	T2080	T2081	punct	(,gift
R1235	T2081	T1968	parataxis	gift,line
R1236	T2082	T2081	det	a,gift
R1237	T2083	T2081	prep	from,gift
R1238	T2084	T2085	compound	Prof.,Aguet
R1239	T2085	T2083	pobj	Aguet,from
R1240	T2086	T2085	compound	Michel,Aguet
R1241	T2087	T2081	punct	),gift
R1242	T2088	T2089	aux	to,obtain
R1243	T2089	T1959	advcl	obtain,crossed
R1244	T2090	T2091	det	an,line
R1245	T2091	T2089	dobj	line,obtain
R1246	T2092	T2091	amod	inducible,line
R1247	T2093	T2091	punct	", ",line
R1248	T2094	T2095	npadvmod	liver,specific
R1249	T2095	T2091	amod	specific,line
R1250	T2096	T2095	punct	-,specific
R1251	T2097	T2098	compound	Mtf1,knockout
R1252	T2098	T2091	compound	knockout,line
R1253	T2099	T1959	punct	.,crossed
R1254	T2101	T2102	det	The,mice
R1255	T2102	T2103	nsubjpass	mice,genotyped
R1256	T2104	T2103	auxpass	were,genotyped
R1257	T2105	T2103	prep	by,genotyped
R1258	T2106	T2105	pobj	PCR,by
R1259	T2107	T2103	advcl	using,genotyped
R1260	T2108	T2109	det	the,primers
R1261	T2109	T2107	dobj	primers,using
R1262	T2110	T2109	amod	following,primers
R1263	T2111	T2112	punct	(,Microsynth
R1264	T2112	T2109	parataxis	Microsynth,primers
R1265	T2113	T2112	punct	),Microsynth
R1266	T2114	T2103	punct	: ,genotyped
R1267	T2115	T2116	compound	Cre,recombinase
R1268	T2116	T2117	dep	recombinase,CCAGGTTACGGATATAGTTCATGAC
R1269	T2117	T2130	dep	CCAGGTTACGGATATAGTTCATGAC,CAGTCACAAGCAAATTACCAAACACTGCC
R1270	T2118	T2117	punct	: ,CCAGGTTACGGATATAGTTCATGAC
R1271	T2119	T2120	nummod	5,CTATCCAGCAACATTTGGGCCAGC
R1272	T2120	T2117	dep	CTATCCAGCAACATTTGGGCCAGC,CCAGGTTACGGATATAGTTCATGAC
R1273	T2121	T2119	punct	′,5
R1274	T2122	T2120	punct	-,CTATCCAGCAACATTTGGGCCAGC
R1275	T2123	T2120	punct	-,CTATCCAGCAACATTTGGGCCAGC
R1276	T2124	T2120	nummod	3,CTATCCAGCAACATTTGGGCCAGC
R1277	T2125	T2120	punct	′,CTATCCAGCAACATTTGGGCCAGC
R1278	T2126	T2117	punct	;,CCAGGTTACGGATATAGTTCATGAC
R1279	T2127	T2117	nummod	5,CCAGGTTACGGATATAGTTCATGAC
R1280	T2128	T2127	punct	′,5
R1281	T2129	T2117	punct	-,CCAGGTTACGGATATAGTTCATGAC
R1282	T2130	T2103	dep	CAGTCACAAGCAAATTACCAAACACTGCC,genotyped
R1283	T2131	T2117	punct	-,CCAGGTTACGGATATAGTTCATGAC
R1284	T2132	T2117	nummod	3,CCAGGTTACGGATATAGTTCATGAC
R1285	T2133	T2117	punct	′,CCAGGTTACGGATATAGTTCATGAC
R1286	T2134	T2130	punct	", ",CAGTCACAAGCAAATTACCAAACACTGCC
R1287	T2135	T2130	dep	Mtf1loxP,CAGTCACAAGCAAATTACCAAACACTGCC
R1288	T2136	T2135	cc	or,Mtf1loxP
R1289	T2137	T2138	amod	wild,type
R1290	T2138	T2140	compound	type,allele
R1291	T2139	T2138	punct	-,type
R1292	T2140	T2135	conj	allele,Mtf1loxP
R1293	T2141	T2130	punct	: ,CAGTCACAAGCAAATTACCAAACACTGCC
R1294	T2142	T2143	nummod	5,CACACCCAGTTTGTGTATGTCTTC
R1295	T2143	T2130	dep	CACACCCAGTTTGTGTATGTCTTC,CAGTCACAAGCAAATTACCAAACACTGCC
R1296	T2144	T2142	punct	′,5
R1297	T2145	T2143	punct	-,CACACCCAGTTTGTGTATGTCTTC
R1298	T2146	T2143	punct	-,CACACCCAGTTTGTGTATGTCTTC
R1299	T2147	T2143	nummod	3,CACACCCAGTTTGTGTATGTCTTC
R1300	T2148	T2143	punct	′,CACACCCAGTTTGTGTATGTCTTC
R1301	T2149	T2130	punct	;,CAGTCACAAGCAAATTACCAAACACTGCC
R1302	T2150	T2130	nummod	5,CAGTCACAAGCAAATTACCAAACACTGCC
R1303	T2151	T2150	punct	′,5
R1304	T2152	T2130	punct	-,CAGTCACAAGCAAATTACCAAACACTGCC
R1305	T2153	T2130	punct	-,CAGTCACAAGCAAATTACCAAACACTGCC
R1306	T2154	T2130	nummod	3,CAGTCACAAGCAAATTACCAAACACTGCC
R1307	T2155	T2130	punct	′,CAGTCACAAGCAAATTACCAAACACTGCC
R1308	T2156	T2103	punct	.,genotyped
R1309	T2173	T2174	compound	Animal,treatment
R1310	T2176	T2177	prep	At,received
R1311	T2178	T2179	nummod	8,weeks
R1312	T2179	T2176	pobj	weeks,At
R1313	T2180	T2179	prep	of,weeks
R1314	T2181	T2180	pobj	age,of
R1315	T2182	T2177	punct	", ",received
R1316	T2183	T2184	amod	male,mice
R1317	T2184	T2177	nsubj	mice,received
R1318	T2185	T2186	compound	Mtf1loxP,loxP
R1319	T2186	T2184	compound	loxP,mice
R1320	T2187	T2186	punct	/,loxP
R1321	T2188	T2184	acl	harboring,mice
R1322	T2189	T2190	det	the,transgene
R1323	T2190	T2188	dobj	transgene,harboring
R1324	T2191	T2192	compound	Mx,cre
R1325	T2192	T2190	compound	cre,transgene
R1326	T2193	T2192	punct	-,cre
R1327	T2194	T2190	punct	(,transgene
R1328	T2195	T2196	compound	Mtf1loxP,cre
R1330	T2197	T2196	punct	/,cre
R1331	T2198	T2196	compound	loxP,cre
R1332	T2199	T2196	compound	Mx,cre
R1333	T2200	T2196	punct	-,cre
R1334	T2201	T2196	punct	", ",cre
R1335	T2202	T2203	advmod	abbr.,cre
R1336	T2203	T2196	appos	cre,cre
R1337	T2204	T2203	punct	: ,cre
R1338	T2205	T2203	compound	Mtf1Mx,cre
R1339	T2206	T2203	punct	-,cre
R1340	T2207	T2190	punct	),transgene
R1341	T2208	T2190	cc	and,transgene
R1342	T2209	T2210	compound	control,littermates
R1343	T2210	T2190	conj	littermates,transgene
R1344	T2211	T2210	prep	without,littermates
R1345	T2212	T2211	pobj	transgene,without
R1346	T2213	T2210	punct	(,littermates
R1347	T2214	T2215	compound	Mtf1loxP,loxP
R1348	T2215	T2210	appos	loxP,littermates
R1349	T2216	T2215	punct	/,loxP
R1350	T2217	T2215	punct	", ",loxP
R1351	T2218	T2219	advmod	abbr.,Mtf1loxP
R1352	T2219	T2215	appos	Mtf1loxP,loxP
R1353	T2220	T2219	punct	: ,Mtf1loxP
R1354	T2221	T2177	punct	),received
R1355	T2222	T2223	nummod	four,injections
R1356	T2223	T2177	dobj	injections,received
R1357	T2224	T2223	amod	intraperitoneal,injections
R1358	T2225	T2223	advmod	each,injections
R1359	T2226	T2223	prep	of,injections
R1360	T2227	T2228	nummod	300,µg
R1361	T2228	T2229	nmod	µg,acid
R1362	T2229	T2226	pobj	acid,of
R1363	T2230	T2229	amod	synthetic,acid
R1364	T2231	T2232	amod	double,stranded
R1365	T2232	T2229	amod	stranded,acid
R1366	T2233	T2323	nummod	20,µmol
R1367	T2234	T2232	punct	-,stranded
R1368	T2235	T2229	nmod	RNA,acid
R1369	T2236	T2237	amod	polyinosinic,polycytidylic
R1370	T2237	T2229	amod	polycytidylic,acid
R1371	T2238	T2237	punct	–,polycytidylic
R1372	T2239	T2240	punct	[,Sigma
R1373	T2240	T2229	parataxis	Sigma,acid
R1374	T2241	T2242	compound	pI,pC
R1375	T2242	T2240	dep	pC,Sigma
R1376	T2243	T2242	punct	–,pC
R1377	T2244	T2240	punct	;,Sigma
R1378	T2245	T2240	punct	;,Sigma
R1379	T2246	T2240	prep	in,Sigma
R1380	T2247	T2248	det	a,volume
R1381	T2248	T2246	pobj	volume,in
R1382	T2249	T2248	prep	of,volume
R1383	T2250	T2251	nummod	60,µl
R1384	T2251	T2249	pobj	µl,of
R1385	T2252	T2253	npadvmod	phosphate,buffered
R1386	T2253	T2255	amod	buffered,saline
R1387	T2254	T2253	punct	-,buffered
R1388	T2255	T2251	appos	saline,µl
R1389	T2256	T2255	punct	(,saline
R1390	T2257	T2255	appos	PBS,saline
R1391	T2258	T2240	punct	),Sigma
R1392	T2259	T2240	punct	],Sigma
R1393	T2260	T2177	prep	at,received
R1394	T2261	T2262	nummod	3,day
R1395	T2262	T2263	compound	day,intervals
R1396	T2263	T2260	pobj	intervals,at
R1397	T2264	T2177	punct	.,received
R1398	T2266	T2267	advmod	Only,in
R1399	T2267	T2268	prep	in,received
R1400	T2269	T2270	det	the,case
R1401	T2270	T2267	pobj	case,in
R1402	T2271	T2270	prep	of,case
R1403	T2272	T2273	npadvmod	DNA,binding
R1404	T2273	T2275	amod	binding,studies
R1405	T2274	T2273	punct	-,binding
R1406	T2275	T2271	pobj	studies,of
R1407	T2276	T2275	prep	with,studies
R1408	T2277	T2278	compound	MRE,sequences
R1409	T2278	T2276	pobj	sequences,with
R1410	T2279	T2278	prep	from,sequences
R1411	T2280	T2281	nmod	MTF,candidates
R1412	T2281	T2279	pobj	candidates,from
R1413	T2282	T2280	punct	-,MTF
R1414	T2283	T2280	nummod	1,MTF
R1415	T2284	T2285	compound	target,gene
R1416	T2285	T2281	compound	gene,candidates
R1417	T2286	T2268	punct	", ",received
R1418	T2287	T2288	det	the,mice
R1419	T2288	T2268	nsubj	mice,received
R1420	T2289	T2288	compound	control,mice
R1421	T2290	T2291	det	no,injections
R1422	T2291	T2268	dobj	injections,received
R1423	T2292	T2293	compound	pI,pC
R1424	T2293	T2291	compound	pC,injections
R1425	T2294	T2293	punct	–,pC
R1426	T2295	T2268	punct	.,received
R1427	T2297	T2298	prep	For,received
R1428	T2299	T2297	pobj	experiments,For
R1429	T2300	T2299	prep	with,experiments
R1430	T2301	T2302	compound	metal,treatment
R1431	T2302	T2300	pobj	treatment,with
R1432	T2303	T2298	punct	", ",received
R1433	T2304	T2298	nsubj	mice,received
R1434	T2305	T2306	nummod	2,days
R1435	T2306	T2307	npadvmod	days,after
R1436	T2307	T2298	prep	after,received
R1437	T2308	T2309	det	the,treatment
R1438	T2309	T2307	pobj	treatment,after
R1439	T2310	T2309	amod	last,treatment
R1440	T2311	T2312	compound	pI,pC
R1441	T2312	T2309	compound	pC,treatment
R1442	T2313	T2312	punct	–,pC
R1443	T2314	T2315	det	a,injection
R1444	T2315	T2298	dobj	injection,received
R1445	T2316	T2317	amod	subcutaneous,s.c.
R1446	T2317	T2315	amod	s.c.,injection
R1447	T2318	T2317	punct	(,s.c.
R1448	T2319	T2315	punct	),injection
R1449	T2320	T2315	prep	of,injection
R1450	T2321	T2322	preconj	either,CdSO4
R1451	T2322	T2320	pobj	CdSO4,of
R1452	T2323	T2322	nmod	µmol,CdSO4
R1453	T2324	T2325	punct	/,weight
R1454	T2325	T2323	prep	weight,µmol
R1455	T2326	T2325	compound	kg,weight
R1456	T2327	T2325	compound	body,weight
R1457	T2328	T2329	punct	(,treatment
R1458	T2329	T2322	parataxis	treatment,CdSO4
R1459	T2330	T2331	nummod	2,mM
R1460	T2331	T2332	compound	mM,CdSO4
R1461	T2332	T2329	dep	CdSO4,treatment
R1462	T2333	T2332	prep	in,CdSO4
R1463	T2334	T2333	pobj	H2O,in
R1464	T2335	T2329	punct	;,treatment
R1465	T2336	T2329	compound	cadmium,treatment
R1466	T2337	T2329	punct	),treatment
R1467	T2338	T2322	cc	or,CdSO4
R1468	T2339	T2340	nummod	10,ml
R1469	T2340	T2341	nmod	ml,H2O
R1471	T2342	T2343	punct	/,weight
R1472	T2343	T2340	prep	weight,ml
R1473	T2344	T2343	compound	kg,weight
R1474	T2345	T2343	compound	body,weight
R1475	T2346	T2347	punct	(,treatment
R1476	T2347	T2341	parataxis	treatment,H2O
R1477	T2348	T2347	amod	mock,treatment
R1478	T2349	T2347	punct	),treatment
R1479	T2350	T2351	nummod	6,h
R1480	T2351	T2352	npadvmod	h,before
R1481	T2352	T2298	prep	before,received
R1482	T2353	T2352	pcomp	sacrificing,before
R1483	T2354	T2353	dobj	them,sacrificing
R1484	T2355	T2298	punct	.,received
R1487	T2531	T2532	compound	Microarray,analysis
R1488	T2533	T2532	cc	and,analysis
R1489	T2534	T2535	compound	data,processing
R1490	T2535	T2532	conj	processing,analysis
R1491	T2537	T2538	amod	Total,RNA
R1492	T2538	T2539	nsubjpass	RNA,isolated
R1493	T2540	T2539	auxpass	was,isolated
R1494	T2541	T2539	prep	from,isolated
R1495	T2542	T2543	compound	liver,tissue
R1496	T2543	T2541	pobj	tissue,from
R1497	T2544	T2543	prep	of,tissue
R1498	T2545	T2546	compound	pI,pC
R1499	T2546	T2548	npadvmod	pC,induced
R1500	T2547	T2546	punct	–,pC
R1501	T2548	T2550	amod	induced,mice
R1502	T2549	T2548	punct	-,induced
R1503	T2550	T2544	pobj	mice,of
R1504	T2551	T2550	punct	", ",mice
R1505	T2552	T2553	amod	mock,treated
R1506	T2553	T2550	amod	treated,mice
R1507	T2554	T2552	punct	-,mock
R1508	T2555	T2552	cc	or,mock
R1509	T2556	T2552	conj	cadmium,mock
R1510	T2557	T2553	punct	-,treated
R1511	T2558	T2559	nmod	Mtf1Mx,cre
R1512	T2559	T2550	nmod	cre,mice
R1513	T2560	T2559	punct	-,cre
R1514	T2561	T2559	cc	and,cre
R1515	T2562	T2559	conj	Mtf1loxP,cre
R1516	T2563	T2564	punct	(,male
R1517	T2564	T2544	parataxis	male,of
R1518	T2565	T2566	nsubj	n,3
R1519	T2566	T2564	ccomp	3,male
R1520	T2567	T2566	punct	=,3
R1521	T2568	T2566	prep	per,3
R1522	T2569	T2568	pobj	genotype,per
R1523	T2570	T2569	cc	and,genotype
R1524	T2571	T2572	amod	respective,treatment
R1525	T2572	T2569	conj	treatment,genotype
R1526	T2573	T2564	punct	;,male
R1527	T2574	T2564	det	all,male
R1528	T2575	T2564	punct	),male
R1529	T2576	T2577	advmod	essentially,described
R1530	T2577	T2539	advcl	described,isolated
R1531	T2578	T2577	mark	as,described
R1532	T2579	T2577	agent	by,described
R1533	T2580	T2579	pobj	Chomczynski,by
R1534	T2581	T2580	cc	and,Chomczynski
R1535	T2582	T2580	conj	Sacchi,Chomczynski
R1536	T2583	T2584	punct	(,27
R1537	T2584	T2577	parataxis	27,described
R1538	T2585	T2584	punct	),27
R1539	T2586	T2539	punct	.,isolated
R1540	T2588	T2589	compound	Gene,expression
R1541	T2589	T2590	compound	expression,analysis
R1542	T2590	T2591	nsubjpass	analysis,performed
R1543	T2592	T2591	auxpass	was,performed
R1544	T2593	T2591	prep	in,performed
R1545	T2594	T2595	det	the,Center
R1546	T2595	T2593	pobj	Center,in
R1547	T2596	T2597	compound	Functional,Genomics
R1548	T2597	T2595	compound	Genomics,Center
R1549	T2598	T2595	npadvmod	Zurich,Center
R1550	T2599	T2591	advcl	using,performed
R1551	T2600	T2601	nmod	GeneChip®,Arrays
R1552	T2601	T2599	dobj	Arrays,using
R1553	T2602	T2603	nmod	Mouse,Genome
R1554	T2603	T2601	nmod	Genome,Arrays
R1555	T2604	T2603	nummod	430,Genome
R1556	T2605	T2601	nummod	2.0,Arrays
R1557	T2606	T2607	punct	(,Affymetrix
R1558	T2607	T2601	parataxis	Affymetrix,Arrays
R1559	T2608	T2607	punct	),Affymetrix
R1560	T2609	T2599	prep	according,using
R1561	T2610	T2609	prep	to,according
R1562	T2611	T2612	det	the,manufacturer
R1563	T2612	T2613	poss	manufacturer,instructions
R1564	T2613	T2610	pobj	instructions,to
R1565	T2614	T2612	case	's,manufacturer
R1566	T2615	T2613	cc	and,instructions
R1567	T2616	T2617	det	the,reagents
R1568	T2617	T2613	conj	reagents,instructions
R1569	T2618	T2617	amod	following,reagents
R1570	T2619	T2617	cc	and,reagents
R1571	T2620	T2617	conj	conditions,reagents
R1572	T2621	T2591	punct	.,performed
R1573	T2623	T2624	nsubjpass	cDNA,synthesized
R1574	T2625	T2624	auxpass	was,synthesized
R1575	T2626	T2624	prep	with,synthesized
R1576	T2627	T2628	nmod	SuperScript,Kit
R1578	T2629	T2627	punct	™,SuperScript
R1579	T2630	T2631	amod	Double,Stranded
R1580	T2631	T2628	amod	Stranded,Kit
R1581	T2632	T2631	punct	-,Stranded
R1582	T2633	T2628	compound	cDNA,Kit
R1583	T2634	T2628	compound	Synthesis,Kit
R1584	T2635	T2636	punct	(,Invitrogen
R1585	T2636	T2628	parataxis	Invitrogen,Kit
R1586	T2637	T2636	punct	),Invitrogen
R1587	T2638	T2624	punct	", ",synthesized
R1588	T2639	T2624	advcl	using,synthesized
R1589	T2640	T2641	nummod	15,µg
R1590	T2641	T2642	nmod	µg,RNA
R1591	T2642	T2639	dobj	RNA,using
R1592	T2643	T2642	amod	total,RNA
R1593	T2644	T2624	punct	.,synthesized
R1594	T2646	T2647	advmod	In,vitro
R1595	T2647	T2648	amod	vitro,transcription
R1596	T2648	T2649	nsubjpass	transcription,performed
R1597	T2650	T2649	auxpass	was,performed
R1598	T2651	T2649	prep	with,performed
R1599	T2652	T2653	nmod	BioArray,Kit
R1600	T2653	T2651	pobj	Kit,with
R1601	T2654	T2652	punct	™,BioArray
R1602	T2655	T2656	nmod	High,Yield
R1603	T2656	T2653	nmod	Yield,Kit
R1604	T2657	T2656	punct	™,Yield
R1605	T2658	T2653	compound	RNA,Kit
R1606	T2659	T2653	compound	Transcript,Kit
R1607	T2660	T2653	compound	Labeling,Kit
R1608	T2661	T2662	punct	(,Enzo
R1609	T2662	T2653	parataxis	Enzo,Kit
R1610	T2663	T2662	punct	),Enzo
R1611	T2664	T2653	cc	and,Kit
R1612	T2665	T2666	quantmod	3.5,6
R1613	T2666	T2668	nummod	6,µg
R1614	T2667	T2666	quantmod	to,6
R1615	T2668	T2653	conj	µg,Kit
R1616	T2669	T2668	prep	of,µg
R1617	T2670	T2671	det	each,cDNA
R1618	T2671	T2669	pobj	cDNA,of
R1619	T2672	T2649	punct	.,performed
R1620	T2674	T2675	compound	Clean,up
R1621	T2675	T2677	nsubjpass	up,done
R1622	T2676	T2675	punct	-,up
R1623	T2678	T2675	prep	of,up
R1624	T2679	T2680	preconj	both,cDNA
R1625	T2680	T2681	nmod	cDNA,samples
R1626	T2681	T2678	pobj	samples,of
R1627	T2682	T2680	cc	and,cDNA
R1628	T2683	T2680	conj	cRNA,cDNA
R1629	T2684	T2677	auxpass	was,done
R1630	T2685	T2677	advcl	using,done
R1631	T2686	T2687	compound	GeneChip®,Module
R1632	T2687	T2685	dobj	Module,using
R1633	T2688	T2687	compound	Sample,Module
R1634	T2689	T2690	compound	Clean,up
R1635	T2690	T2687	compound	up,Module
R1636	T2691	T2690	punct	-,up
R1637	T2692	T2693	punct	(,Affymetrix
R1638	T2693	T2687	parataxis	Affymetrix,Module
R1639	T2694	T2693	punct	),Affymetrix
R1640	T2695	T2677	punct	.,done
R1641	T2697	T2698	prep	For,used
R1642	T2699	T2700	det	the,washing
R1643	T2700	T2697	pobj	washing,For
R1644	T2701	T2700	amod	automated,washing
R1645	T2702	T2700	cc	and,washing
R1646	T2703	T2700	conj	staining,washing
R1647	T2704	T2700	prep	in,washing
R1648	T2705	T2706	det	the,station
R1649	T2706	T2704	pobj	station,in
R1650	T2707	T2706	compound	Affymetrix,station
R1651	T2708	T2706	compound	fluidics,station
R1652	T2709	T2706	nummod	450,station
R1653	T2710	T2698	punct	", ",used
R1654	T2711	T2712	det	the,Ws2v4_450
R1655	T2712	T2698	nsubjpass	Ws2v4_450,used
R1656	T2713	T2712	compound	protocol,Ws2v4_450
R1657	T2714	T2712	compound	EukGE,Ws2v4_450
R1658	T2715	T2712	punct	-,Ws2v4_450
R1659	T2716	T2698	auxpass	was,used
R1660	T2717	T2698	punct	.,used
R1661	T2719	T2720	det	The,arrays
R1662	T2720	T2722	nsubjpass	arrays,scanned
R1663	T2721	T2720	compound	probe,arrays
R1664	T2723	T2722	auxpass	were,scanned
R1665	T2724	T2722	prep	with,scanned
R1666	T2725	T2726	det	the,scanner
R1667	T2726	T2724	pobj	scanner,with
R1668	T2727	T2728	nmod	Affymetrix,GS
R1669	T2728	T2726	nmod	GS,scanner
R1670	T2729	T2728	nummod	3000,GS
R1671	T2730	T2722	punct	.,scanned
R1672	T2732	T2733	amod	Raw,data
R1673	T2733	T2734	nsubj	data,are
R1674	T2735	T2734	acomp	available,are
R1675	T2736	T2734	prep	at,are
R1676	T2737	T2736	pobj	ArrayExpress,at
R1677	T2738	T2739	punct	(,MEXP
R1678	T2739	T2734	parataxis	MEXP,are
R1679	T2740	T2739	punct	", ",MEXP
R1680	T2741	T2742	compound	accession,number
R1681	T2742	T2739	compound	number,MEXP
R1682	T2743	T2739	compound	E,MEXP
R1683	T2744	T2739	punct	-,MEXP
R1684	T2745	T2739	punct	-,MEXP
R1685	T2746	T2739	nummod	438,MEXP
R1686	T2747	T2739	punct	),MEXP
R1687	T2748	T2734	punct	.,are
R1688	T2750	T2751	compound	Data,analysis
R1689	T2751	T2752	nsubjpass	analysis,performed
R1690	T2753	T2752	auxpass	was,performed
R1691	T2754	T2752	prep	with,performed
R1692	T2755	T2756	nmod	GeneSpring,software
R1693	T2756	T2754	pobj	software,with
R1694	T2757	T2756	nummod	6.1,software
R1695	T2758	T2759	punct	(,Genetics
R1696	T2759	T2756	parataxis	Genetics,software
R1697	T2760	T2759	compound	Silicon,Genetics
R1698	T2761	T2759	punct	),Genetics
R1699	T2762	T2752	punct	", ",performed
R1700	T2763	T2752	advcl	applying,performed
R1701	T2764	T2765	det	a,level
R1702	T2765	T2763	dobj	level,applying
R1703	T2766	T2765	compound	significance,level
R1704	T2767	T2768	nsubj	P,0.05
R1705	T2768	T2765	appos	0.05,level
R1706	T2769	T2768	punct	≤,0.05
R1707	T2770	T2752	punct	.,performed
R1708	T2772	T2773	advmod	Furthermore,used
R1709	T2774	T2773	punct	", ",used
R1710	T2775	T2776	amod	multiple,correction
R1711	T2776	T2773	nsubjpass	correction,used
R1712	T2777	T2776	compound	testing,correction
R1713	T2778	T2773	auxpass	was,used
R1714	T2779	T2773	prep	in,used
R1715	T2780	T2779	pobj	addition,in
R1716	T2781	T2782	aux	to,obtain
R1717	T2782	T2773	advcl	obtain,used
R1718	T2783	T2784	npadvmod	cadmium,responsive
R1719	T2784	T2786	amod	responsive,genes
R1720	T2785	T2784	punct	-,responsive
R1722	T2787	T2786	punct	", ",genes
R1723	T2788	T2789	npadvmod	MTF,independent
R1724	T2789	T2786	amod	independent,genes
R1725	T2790	T2788	punct	-,MTF
R1726	T2791	T2788	nummod	1,MTF
R1727	T2792	T2789	punct	-,independent
R1728	T2793	T2773	punct	.,used
R1729	T2795	T2796	nsubjpass	Genes,considered
R1730	T2797	T2796	auxpass	were,considered
R1731	T2798	T2799	aux	to,expressed
R1732	T2799	T2796	xcomp	expressed,considered
R1733	T2800	T2799	auxpass	be,expressed
R1734	T2801	T2799	advmod	differentially,expressed
R1735	T2802	T2803	mark	if,was
R1736	T2803	T2799	advcl	was,expressed
R1737	T2804	T2803	expl	there,was
R1738	T2805	T2806	advmod	at,least
R1739	T2806	T2807	advmod	least,2-fold
R1740	T2807	T2809	nummod	2-fold,difference
R1741	T2808	T2807	quantmod	a,2-fold
R1742	T2809	T2803	attr	difference,was
R1743	T2810	T2809	prep	in,difference
R1744	T2811	T2812	compound	expression,levels
R1745	T2812	T2810	pobj	levels,in
R1746	T2813	T2812	prep	of,levels
R1747	T2814	T2815	det	the,groups
R1748	T2815	T2813	pobj	groups,of
R1749	T2816	T2815	amod	compared,groups
R1750	T2817	T2815	amod	experimental,groups
R1751	T2818	T2819	punct	(,genotype
R1752	T2819	T2803	parataxis	genotype,was
R1753	T2820	T2819	cc	and,genotype
R1754	T2821	T2822	amod	respective,treatment
R1755	T2822	T2819	conj	treatment,genotype
R1756	T2823	T2819	punct	),genotype
R1757	T2824	T2796	punct	.,considered
R1758	T2826	T2827	det	The,result
R1759	T2827	T2828	nsubjpass	result,considered
R1760	T2829	T2828	auxpass	was,considered
R1761	T2830	T2828	oprd	reliable,considered
R1762	T2831	T2832	mark	if,scored
R1763	T2832	T2828	advcl	scored,considered
R1764	T2833	T2834	compound	signal,values
R1765	T2834	T2832	nsubjpass	values,scored
R1766	T2835	T2834	prep	for,values
R1767	T2836	T2837	det	the,gene
R1768	T2837	T2835	pobj	gene,for
R1769	T2838	T2837	amod	respective,gene
R1770	T2839	T2832	auxpass	were,scored
R1771	T2840	T2841	punct	‘,present
R1772	T2841	T2832	oprd	present,scored
R1773	T2842	T2832	punct	’,scored
R1774	T2843	T2844	advmod	at,least
R1775	T2844	T2845	advmod	least,for
R1776	T2845	T2828	prep	for,considered
R1777	T2846	T2847	det	all,mice
R1778	T2847	T2845	pobj	mice,for
R1779	T2848	T2847	prep	in,mice
R1780	T2849	T2850	nummod	one,group
R1781	T2850	T2848	pobj	group,in
R1782	T2851	T2850	amod	experimental,group
R1783	T2852	T2845	cc	or,for
R1784	T2853	T2845	conj	for,for
R1785	T2854	T2855	nummod	two,mice
R1786	T2855	T2853	pobj	mice,for
R1787	T2856	T2855	prep	in,mice
R1788	T2857	T2856	pobj	each,in
R1789	T2858	T2857	prep	of,each
R1790	T2859	T2860	nummod	two,groups
R1791	T2860	T2858	pobj	groups,of
R1792	T2861	T2828	punct	.,considered
R1793	T2863	T2864	aux	To,screen
R1794	T2864	T2865	advcl	screen,obtained
R1795	T2866	T2864	prep	for,screen
R1796	T2867	T2868	det	the,presence
R1797	T2868	T2866	pobj	presence,for
R1798	T2869	T2868	prep	of,presence
R1799	T2870	T2871	det	the,sequence
R1800	T2871	T2869	pobj	sequence,of
R1801	T2872	T2871	compound	MRE,sequence
R1802	T2873	T2871	compound	core,sequence
R1803	T2874	T2871	compound	consensus,sequence
R1804	T2875	T2871	appos	TGCRCNC,sequence
R1805	T2876	T2868	prep	in,presence
R1806	T2877	T2878	det	the,region
R1807	T2878	T2876	pobj	region,in
R1808	T2879	T2878	compound	promoter,region
R1809	T2880	T2865	punct	", ",obtained
R1810	T2881	T2882	det	the,sequences
R1811	T2882	T2865	nsubjpass	sequences,obtained
R1812	T2883	T2882	amod	upstream,sequences
R1813	T2884	T2882	prep	of,sequences
R1814	T2885	T2886	det	the,genes
R1815	T2886	T2884	pobj	genes,of
R1816	T2887	T2886	amod	respective,genes
R1817	T2888	T2865	auxpass	were,obtained
R1818	T2889	T2865	prep	from,obtained
R1819	T2890	T2891	det	the,Database
R1820	T2891	T2889	pobj	Database,from
R1821	T2892	T2891	nmod	University,Database
R1822	T2893	T2892	prep	of,University
R1823	T2894	T2895	compound	California,Cruz
R1824	T2895	T2893	pobj	Cruz,of
R1825	T2896	T2895	compound	Santa,Cruz
R1826	T2897	T2892	punct	(,University
R1827	T2898	T2892	appos	UCSC,University
R1828	T2899	T2891	punct	),Database
R1829	T2900	T2891	compound	Genome,Database
R1830	T2901	T2891	compound	Browser,Database
R1831	T2902	T2903	punct	(,November
R1832	T2903	T2891	parataxis	November,Database
R1833	T2904	T2903	punct	;,November
R1834	T2905	T2903	nmod	October,November
R1835	T2906	T2903	punct	/,November
R1836	T2907	T2903	nummod	2004,November
R1837	T2908	T2903	punct	),November
R1838	T2909	T2910	punct	(,28
R1839	T2910	T2891	parataxis	28,Database
R1840	T2911	T2910	punct	),28
R1841	T2912	T2865	punct	.,obtained
R1842	T2931	T2989	appos	TTCCGATGTGCCAAGTGTGGC,Csrp1
R1843	T2932	T2933	compound	RT,PCR
R1844	T2934	T2933	punct	–,PCR
R1845	T2936	T2937	det	All,PCRs
R1846	T2937	T2940	nsubjpass	PCRs,performed
R1847	T2938	T2937	compound	RT,PCRs
R1848	T2939	T2937	punct	–,PCRs
R1849	T2941	T2940	auxpass	were,performed
R1850	T2942	T2940	prep	with,performed
R1851	T2943	T2944	compound	QIAGEN®,Kit
R1852	T2944	T2942	pobj	Kit,with
R1853	T2945	T2944	compound	OneStep,Kit
R1854	T2946	T2947	compound	RT,PCR
R1855	T2947	T2944	compound	PCR,Kit
R1856	T2948	T2947	punct	–,PCR
R1857	T2949	T2950	punct	(,QIAGEN
R1858	T2950	T2944	parataxis	QIAGEN,Kit
R1859	T2951	T2950	punct	),QIAGEN
R1860	T2952	T2940	prep	according,performed
R1861	T2953	T2952	prep	to,according
R1862	T2954	T2955	det	the,manufacturer
R1863	T2955	T2956	poss	manufacturer,instructions
R1864	T2956	T2953	pobj	instructions,to
R1865	T2957	T2955	case	's,manufacturer
R1866	T2958	T2940	punct	", ",performed
R1867	T2959	T2940	advcl	using,performed
R1868	T2960	T2961	quantmod	150,200
R1869	T2961	T2963	nummod	200,ng
R1870	T2962	T2961	punct	–,200
R1871	T2963	T2964	nmod	ng,RNA
R1872	T2964	T2959	dobj	RNA,using
R1873	T2965	T2966	compound	DNase,I
R1874	T2966	T2967	npadvmod	I,digested
R1875	T2967	T2964	amod	digested,RNA
R1876	T2968	T2967	punct	-,digested
R1877	T2969	T2964	amod	total,RNA
R1878	T2970	T2971	punct	(,isolation
R1879	T2971	T2959	parataxis	isolation,using
R1880	T2972	T2971	compound	RNA,isolation
R1881	T2973	T2971	advcl	see,isolation
R1882	T2974	T2975	compound	microarray,analysis
R1883	T2975	T2973	dobj	analysis,see
R1884	T2976	T2971	punct	),isolation
R1885	T2977	T2940	punct	.,performed
R1886	T2979	T2980	det	The,reactions
R1887	T2980	T2981	nsubjpass	reactions,carried
R1888	T2982	T2981	auxpass	were,carried
R1889	T2983	T2981	prt	out,carried
R1890	T2984	T2981	advcl	using,carried
R1891	T2985	T2986	det	the,primers
R1892	T2986	T2984	dobj	primers,using
R1893	T2987	T2986	amod	following,primers
R1894	T2988	T2986	punct	: ,primers
R1895	T2989	T2986	appos	Csrp1,primers
R1896	T2990	T2989	punct	: ,Csrp1
R1897	T2991	T2931	nummod	5,TTCCGATGTGCCAAGTGTGGC
R1898	T2992	T2991	punct	′,5
R1899	T2993	T2931	punct	-,TTCCGATGTGCCAAGTGTGGC
R1900	T2994	T2931	punct	-,TTCCGATGTGCCAAGTGTGGC
R1901	T2995	T2931	nummod	3,TTCCGATGTGCCAAGTGTGGC
R1902	T2996	T2931	punct	′,TTCCGATGTGCCAAGTGTGGC
R1903	T2997	T2931	punct	;,TTCCGATGTGCCAAGTGTGGC
R1904	T2998	T2999	nummod	5,AGTAGAGAGTGGACATTCAGC
R1905	T2999	T2931	appos	AGTAGAGAGTGGACATTCAGC,TTCCGATGTGCCAAGTGTGGC
R1906	T3000	T2998	punct	′,5
R1907	T3001	T2999	punct	-,AGTAGAGAGTGGACATTCAGC
R1908	T3002	T2999	punct	-,AGTAGAGAGTGGACATTCAGC
R1909	T3003	T2999	nummod	3,AGTAGAGAGTGGACATTCAGC
R1910	T3004	T2999	punct	′,AGTAGAGAGTGGACATTCAGC
R1911	T3005	T2989	punct	", ",Csrp1
R1912	T3006	T3007	compound	hypoxanthin,phosphoribosyltransferase
R1913	T3007	T2989	appos	phosphoribosyltransferase,Csrp1
R1914	T3008	T3007	punct	-,phosphoribosyltransferase
R1915	T3009	T3007	compound	guanin,phosphoribosyltransferase
R1916	T3010	T3007	punct	-,phosphoribosyltransferase
R1917	T3011	T3007	punct	(,phosphoribosyltransferase
R1918	T3012	T3007	appos	Hprt,phosphoribosyltransferase
R1919	T3013	T3007	punct	),phosphoribosyltransferase
R1920	T3014	T3007	punct	: ,phosphoribosyltransferase
R1921	T3015	T3016	nummod	5,GCTGGTGAAAAGGACCTCTCG
R1922	T3016	T3007	appos	GCTGGTGAAAAGGACCTCTCG,phosphoribosyltransferase
R1923	T3017	T3015	punct	′,5
R1924	T3018	T3016	punct	-,GCTGGTGAAAAGGACCTCTCG
R1925	T3019	T3016	punct	-,GCTGGTGAAAAGGACCTCTCG
R1926	T3020	T3016	nummod	3,GCTGGTGAAAAGGACCTCTCG
R1927	T3021	T3016	punct	′,GCTGGTGAAAAGGACCTCTCG
R1928	T3022	T3016	punct	;,GCTGGTGAAAAGGACCTCTCG
R1929	T3023	T3024	nummod	5,CCACAGGACTAGGACACCTGC
R1930	T3024	T3016	appos	CCACAGGACTAGGACACCTGC,GCTGGTGAAAAGGACCTCTCG
R1931	T3025	T3023	punct	′,5
R1932	T3026	T3024	punct	-,CCACAGGACTAGGACACCTGC
R1933	T3027	T3024	punct	-,CCACAGGACTAGGACACCTGC
R1934	T3028	T3024	nummod	3,CCACAGGACTAGGACACCTGC
R1935	T3029	T3024	punct	′,CCACAGGACTAGGACACCTGC
R1936	T3030	T2989	punct	", ",Csrp1
R1937	T3031	T2989	appos	Mtf1,Csrp1
R1938	T3032	T3031	punct	: ,Mtf1
R1939	T3033	T3034	nummod	5,GTGACTTTTGAGACTGTACTGAGTG
R1940	T3034	T3031	appos	GTGACTTTTGAGACTGTACTGAGTG,Mtf1
R1941	T3035	T3033	punct	′,5
R1942	T3036	T3034	punct	-,GTGACTTTTGAGACTGTACTGAGTG
R1943	T3037	T3034	punct	-,GTGACTTTTGAGACTGTACTGAGTG
R1944	T3038	T3034	nummod	3,GTGACTTTTGAGACTGTACTGAGTG
R1945	T3039	T3034	punct	′,GTGACTTTTGAGACTGTACTGAGTG
R1946	T3040	T3034	punct	;,GTGACTTTTGAGACTGTACTGAGTG
R1947	T3041	T3042	nummod	5,CATGCCAAGAAACATTGAAGGTG
R1948	T3042	T3034	appos	CATGCCAAGAAACATTGAAGGTG,GTGACTTTTGAGACTGTACTGAGTG
R1949	T3043	T3041	punct	′,5
R1950	T3044	T3042	punct	-,CATGCCAAGAAACATTGAAGGTG
R1951	T3045	T3042	punct	-,CATGCCAAGAAACATTGAAGGTG
R1952	T3046	T3042	nummod	3,CATGCCAAGAAACATTGAAGGTG
R1953	T3047	T3042	punct	′,CATGCCAAGAAACATTGAAGGTG
R1954	T3048	T2989	punct	", ",Csrp1
R1955	T3049	T2989	appos	Ndrg1,Csrp1
R1956	T3050	T3049	punct	: ,Ndrg1
R1957	T3051	T3052	nummod	5,AGATACACAACAACGTGGAGG
R1958	T3052	T3049	appos	AGATACACAACAACGTGGAGG,Ndrg1
R1959	T3053	T3051	punct	′,5
R1960	T3054	T3052	punct	-,AGATACACAACAACGTGGAGG
R1961	T3055	T3052	punct	-,AGATACACAACAACGTGGAGG
R1962	T3056	T3052	nummod	3,AGATACACAACAACGTGGAGG
R1963	T3057	T3052	punct	′,AGATACACAACAACGTGGAGG
R1964	T3058	T3052	punct	;,AGATACACAACAACGTGGAGG
R1965	T3059	T3060	nummod	5,TGTGCGAGCGGCTTCGGGGGC
R1966	T3060	T3052	appos	TGTGCGAGCGGCTTCGGGGGC,AGATACACAACAACGTGGAGG
R1967	T3061	T3059	punct	′,5
R1968	T3062	T3060	punct	-,TGTGCGAGCGGCTTCGGGGGC
R1969	T3063	T3060	punct	-,TGTGCGAGCGGCTTCGGGGGC
R1970	T3064	T3060	nummod	3,TGTGCGAGCGGCTTCGGGGGC
R1971	T3065	T3060	punct	′,TGTGCGAGCGGCTTCGGGGGC
R1972	T3066	T2989	punct	", ",Csrp1
R1973	T3067	T2989	appos	Sepw1,Csrp1
R1974	T3068	T3067	punct	: ,Sepw1
R1975	T3069	T3070	nummod	5,TAGAGGCAGGGTCCTGAAAGC
R1976	T3070	T3067	appos	TAGAGGCAGGGTCCTGAAAGC,Sepw1
R1977	T3071	T3069	punct	′,5
R1978	T3072	T3070	punct	-,TAGAGGCAGGGTCCTGAAAGC
R1979	T3073	T3070	punct	-,TAGAGGCAGGGTCCTGAAAGC
R1980	T3074	T3070	nummod	3,TAGAGGCAGGGTCCTGAAAGC
R1981	T3075	T3070	punct	′,TAGAGGCAGGGTCCTGAAAGC
R1982	T3076	T3070	punct	;,TAGAGGCAGGGTCCTGAAAGC
R1983	T3077	T3078	nummod	5,ACACCTGGAAACATGGCTGCC
R1984	T3078	T3070	appos	ACACCTGGAAACATGGCTGCC,TAGAGGCAGGGTCCTGAAAGC
R1985	T3079	T3077	punct	′,5
R1986	T3080	T3078	punct	-,ACACCTGGAAACATGGCTGCC
R1987	T3081	T3078	punct	-,ACACCTGGAAACATGGCTGCC
R1988	T3082	T3078	nummod	3,ACACCTGGAAACATGGCTGCC
R1989	T3083	T3078	punct	′,ACACCTGGAAACATGGCTGCC
R1990	T3084	T2989	punct	", ",Csrp1
R1991	T3085	T2989	appos	Slc39a10,Csrp1
R1992	T3086	T3085	punct	: ,Slc39a10
R1993	T3087	T3088	nummod	5,GCTGTGGCTGGTAGTAAAAGC
R1994	T3088	T3085	appos	GCTGTGGCTGGTAGTAAAAGC,Slc39a10
R1995	T3089	T3087	punct	′,5
R1996	T3090	T3088	punct	-,GCTGTGGCTGGTAGTAAAAGC
R1997	T3091	T3088	punct	-,GCTGTGGCTGGTAGTAAAAGC
R1998	T3092	T3088	nummod	3,GCTGTGGCTGGTAGTAAAAGC
R1999	T3093	T3088	punct	′,GCTGTGGCTGGTAGTAAAAGC
R2000	T3094	T3088	punct	;,GCTGTGGCTGGTAGTAAAAGC
R2001	T3095	T3096	nummod	5,GTGGCATGGGATGTAAACAGC
R2002	T3096	T3088	appos	GTGGCATGGGATGTAAACAGC,GCTGTGGCTGGTAGTAAAAGC
R2003	T3097	T3095	punct	′,5
R2004	T3098	T3096	punct	-,GTGGCATGGGATGTAAACAGC
R2005	T3099	T3096	punct	-,GTGGCATGGGATGTAAACAGC
R2006	T3100	T3096	nummod	3,GTGGCATGGGATGTAAACAGC
R2007	T3101	T3096	punct	′,GTGGCATGGGATGTAAACAGC
R2008	T3102	T2981	punct	.,carried
R2009	T3137	T3138	compound	S1,mapping
R2010	T3139	T3138	compound	nuclease,mapping
R2011	T3140	T3138	prep	of,mapping
R2012	T3141	T3140	pobj	transcripts,of
R2013	T3142	T3143	punct	(,analysis
R2014	T3143	T3138	parataxis	analysis,mapping
R2015	T3144	T3143	compound	S1,analysis
R2016	T3145	T3143	punct	),analysis
R2017	T3147	T3148	compound	S1,analysis
R2018	T3148	T3149	nsubjpass	analysis,performed
R2019	T3150	T3149	auxpass	was,performed
R2020	T3151	T3152	mark	as,described
R2021	T3152	T3149	advcl	described,performed
R2022	T3153	T3152	advmod	previously,described
R2023	T3154	T3155	punct	(,29
R2024	T3155	T3152	parataxis	29,described
R2025	T3156	T3155	punct	),29
R2026	T3157	T3149	punct	", ",performed
R2027	T3158	T3149	advcl	using,performed
R2028	T3159	T3160	nummod	100,µg
R2029	T3160	T3161	nmod	µg,RNA
R2030	T3161	T3158	dobj	RNA,using
R2031	T3162	T3163	npadvmod	DNase,digested
R2032	T3163	T3161	amod	digested,RNA
R2033	T3164	T3162	nummod	I,DNase
R2034	T3165	T3163	punct	-,digested
R2035	T3166	T3161	amod	total,RNA
R2036	T3167	T3168	punct	(,see
R2037	T3168	T3161	parataxis	see,RNA
R2038	T3169	T3170	compound	RNA,isolation
R2039	T3170	T3168	nsubj	isolation,see
R2040	T3171	T3172	compound	microarray,analysis
R2041	T3172	T3168	dobj	analysis,see
R2042	T3173	T3168	punct	),see
R2043	T3174	T3149	punct	.,performed
R2044	T3176	T3177	det	The,gels
R2045	T3177	T3178	nsubjpass	gels,developed
R2046	T3179	T3178	auxpass	were,developed
R2047	T3180	T3178	advcl	using,developed
R2048	T3181	T3180	dobj	PhosphorImager,using
R2049	T3182	T3183	punct	(,Dynamics
R2050	T3183	T3178	parataxis	Dynamics,developed
R2051	T3184	T3183	compound	Molecular,Dynamics
R2052	T3185	T3183	punct	),Dynamics
R2053	T3186	T3178	punct	.,developed
R2054	T3188	T3189	compound	S1,analysis
R2055	T3189	T3190	nsubjpass	analysis,done
R2056	T3191	T3190	auxpass	was,done
R2057	T3192	T3190	prep	with,done
R2058	T3193	T3194	det	the,oligonucleotides
R2059	T3194	T3192	pobj	oligonucleotides,with
R2060	T3195	T3194	amod	following,oligonucleotides
R2061	T3196	T3197	npadvmod	32P,labeled
R2062	T3197	T3194	amod	labeled,oligonucleotides
R2063	T3198	T3197	punct	-,labeled
R2064	T3199	T3194	punct	: ,oligonucleotides
R2065	T3200	T3201	compound	Hprt,S1
R2066	T3201	T3194	appos	S1,oligonucleotides
R2067	T3202	T3201	punct	: ,S1
R2068	T3203	T3204	nummod	5,TCTTCAGTCTGATAAAATCTACAGTCATAGGAATGGATCTATCACTATTTCTATTCAGTGATTACATTAAAG
R2069	T3204	T3201	appos	TCTTCAGTCTGATAAAATCTACAGTCATAGGAATGGATCTATCACTATTTCTATTCAGTGATTACATTAAAG,S1
R2070	T3205	T3203	punct	′,5
R2071	T3206	T3204	punct	-,TCTTCAGTCTGATAAAATCTACAGTCATAGGAATGGATCTATCACTATTTCTATTCAGTGATTACATTAAAG
R2072	T3207	T3204	punct	-,TCTTCAGTCTGATAAAATCTACAGTCATAGGAATGGATCTATCACTATTTCTATTCAGTGATTACATTAAAG
R2073	T3208	T3204	nummod	3,TCTTCAGTCTGATAAAATCTACAGTCATAGGAATGGATCTATCACTATTTCTATTCAGTGATTACATTAAAG
R2074	T3209	T3204	punct	′,TCTTCAGTCTGATAAAATCTACAGTCATAGGAATGGATCTATCACTATTTCTATTCAGTGATTACATTAAAG
R2075	T3210	T3201	punct	", ",S1
R2076	T3211	T3212	compound	Sepw1,S1
R2077	T3212	T3201	appos	S1,S1
R2078	T3213	T3212	punct	: ,S1
R2079	T3214	T3215	nummod	5,TTCAACCGGGAACACCTGGAAACATGGCTGCCTGTCTTCTTGAAGTCTTGAGGTGGAAAGGGAAAGCAAAGCAGGAGGGTTTTCCCACCC
R2080	T3215	T3212	appos	TTCAACCGGGAACACCTGGAAACATGGCTGCCTGTCTTCTTGAAGTCTTGAGGTGGAAAGGGAAAGCAAAGCAGGAGGGTTTTCCCACCC,S1
R2081	T3216	T3214	punct	′,5
R2082	T3217	T3215	punct	-,TTCAACCGGGAACACCTGGAAACATGGCTGCCTGTCTTCTTGAAGTCTTGAGGTGGAAAGGGAAAGCAAAGCAGGAGGGTTTTCCCACCC
R2083	T3218	T3215	punct	-,TTCAACCGGGAACACCTGGAAACATGGCTGCCTGTCTTCTTGAAGTCTTGAGGTGGAAAGGGAAAGCAAAGCAGGAGGGTTTTCCCACCC
R2084	T3219	T3215	nummod	3,TTCAACCGGGAACACCTGGAAACATGGCTGCCTGTCTTCTTGAAGTCTTGAGGTGGAAAGGGAAAGCAAAGCAGGAGGGTTTTCCCACCC
R2085	T3220	T3215	punct	′,TTCAACCGGGAACACCTGGAAACATGGCTGCCTGTCTTCTTGAAGTCTTGAGGTGGAAAGGGAAAGCAAAGCAGGAGGGTTTTCCCACCC
R2086	T3221	T3190	punct	.,done
R2089	T3351	T3352	amod	Electrophoretic,shift
R2090	T3352	T3354	compound	shift,assay
R2091	T3353	T3352	compound	mobility,shift
R2092	T3355	T3354	punct	(,assay
R2093	T3356	T3354	appos	EMSA,assay
R2094	T3357	T3354	punct	),assay
R2095	T3359	T3360	nsubjpass	Protein,extracted
R2096	T3361	T3360	auxpass	was,extracted
R2097	T3362	T3360	prep	from,extracted
R2098	T3363	T3364	compound	liver,tissue
R2099	T3364	T3362	pobj	tissue,from
R2100	T3365	T3360	prep	with,extracted
R2101	T3366	T3367	compound	T,PER
R2102	T3367	T3365	pobj	PER,with
R2103	T3368	T3367	punct	-,PER
R2104	T3369	T3367	punct	™,PER
R2105	T3370	T3371	compound	Tissue,Protein
R2106	T3371	T3372	compound	Protein,Extraction
R2107	T3372	T3373	compound	Extraction,Reagent
R2108	T3373	T3367	appos	Reagent,PER
R2109	T3374	T3375	punct	(,Pierce
R2110	T3375	T3367	parataxis	Pierce,PER
R2111	T3376	T3375	punct	),Pierce
R2112	T3377	T3360	prep	according,extracted
R2113	T3378	T3377	prep	to,according
R2114	T3379	T3380	det	the,manufacturer
R2115	T3380	T3381	poss	manufacturer,instructions
R2116	T3381	T3378	pobj	instructions,to
R2117	T3382	T3380	case	's,manufacturer
R2118	T3383	T3360	punct	", ",extracted
R2119	T3384	T3360	advcl	using,extracted
R2120	T3385	T3386	det	a,ratio
R2121	T3386	T3384	dobj	ratio,using
R2122	T3387	T3386	nummod	1,ratio
R2123	T3388	T3389	punct	:,10
R2124	T3389	T3387	prep	10,1
R2125	T3390	T3386	prep	of,ratio
R2126	T3391	T3392	compound	mouse,tissue
R2127	T3392	T3390	pobj	tissue,of
R2128	T3393	T3394	punct	(,mg
R2129	T3394	T3392	parataxis	mg,tissue
R2130	T3395	T3394	punct	),mg
R2131	T3396	T3386	prep	to,ratio
R2132	T3397	T3398	compound	T,PER
R2133	T3398	T3400	compound	PER,reagent
R2134	T3399	T3398	punct	-,PER
R2135	T3400	T3396	pobj	reagent,to
R2136	T3401	T3402	punct	(,µl
R2137	T3402	T3400	parataxis	µl,reagent
R2138	T3403	T3402	punct	),µl
R2139	T3404	T3360	punct	.,extracted
R2140	T3406	T3407	nsubjpass	EMSA,performed
R2141	T3408	T3407	auxpass	was,performed
R2142	T3409	T3407	advmod	essentially,performed
R2143	T3410	T3411	mark	as,described
R2144	T3411	T3407	advcl	described,performed
R2145	T3412	T3411	advmod	previously,described
R2146	T3413	T3414	punct	(,10
R2147	T3414	T3411	parataxis	10,described
R2148	T3415	T3414	punct	),10
R2149	T3416	T3407	punct	.,performed
R2150	T3418	T3419	det	All,reactions
R2151	T3419	T3421	nsubjpass	reactions,carried
R2152	T3420	T3419	compound	binding,reactions
R2153	T3422	T3421	auxpass	were,carried
R2154	T3423	T3421	prt	out,carried
R2155	T3424	T3421	prep	by,carried
R2156	T3425	T3424	pcomp	incubating,by
R2157	T3426	T3427	quantmod	2,5
R2158	T3427	T3429	nummod	5,fmol
R2159	T3428	T3427	punct	–,5
R2160	T3429	T3430	nmod	fmol,oligonucleotides
R2162	T3431	T3432	npadvmod	32P,labeled
R2163	T3432	T3430	amod	labeled,oligonucleotides
R2164	T3433	T3432	punct	-,labeled
R2165	T3434	T3432	npadvmod	end,labeled
R2166	T3435	T3432	punct	-,labeled
R2167	T3436	T3437	amod	double,stranded
R2168	T3437	T3430	amod	stranded,oligonucleotides
R2169	T3438	T3437	punct	-,stranded
R2170	T3439	T3425	prep	with,incubating
R2171	T3440	T3441	quantmod	100,130
R2172	T3441	T3443	nummod	130,µg
R2173	T3442	T3441	quantmod	to,130
R2174	T3443	T3444	compound	µg,extract
R2175	T3444	T3439	pobj	extract,with
R2176	T3445	T3446	compound	liver,protein
R2177	T3446	T3444	compound	protein,extract
R2178	T3447	T3421	punct	.,carried
R2179	T3449	T3450	prep	For,added
R2180	T3451	T3452	compound	competition,experiments
R2181	T3452	T3449	pobj	experiments,For
R2182	T3453	T3450	punct	", ",added
R2183	T3454	T3455	nummod	5,pmol
R2184	T3455	T3450	nsubjpass	pmol,added
R2185	T3456	T3455	prep	of,pmol
R2186	T3457	T3458	amod	unlabeled,oligonucleotide
R2187	T3458	T3456	pobj	oligonucleotide,of
R2188	T3459	T3458	compound	competitor,oligonucleotide
R2189	T3460	T3450	auxpass	was,added
R2190	T3461	T3450	prep	to,added
R2191	T3462	T3463	det	the,reaction
R2192	T3463	T3461	pobj	reaction,to
R2193	T3464	T3463	compound	binding,reaction
R2194	T3465	T3450	prep	before,added
R2195	T3466	T3465	pobj	addition,before
R2196	T3467	T3466	prep	of,addition
R2197	T3468	T3469	det	the,extract
R2198	T3469	T3467	pobj	extract,of
R2199	T3470	T3450	punct	.,added
R2200	T3472	T3473	det	All,gels
R2201	T3473	T3475	nsubjpass	gels,developed
R2202	T3474	T3473	compound	EMSA,gels
R2203	T3476	T3475	auxpass	were,developed
R2204	T3477	T3475	advcl	using,developed
R2205	T3478	T3477	dobj	PhosphorImager,using
R2206	T3479	T3480	punct	(,Dynamics
R2207	T3480	T3478	parataxis	Dynamics,PhosphorImager
R2208	T3481	T3480	compound	Molecular,Dynamics
R2209	T3482	T3480	punct	),Dynamics
R2210	T3483	T3475	punct	.,developed
R2211	T3485	T3486	det	The,oligonucleotides
R2212	T3486	T3488	nsubjpass	oligonucleotides,annealed
R2213	T3487	T3486	amod	following,oligonucleotides
R2214	T3489	T3488	auxpass	were,annealed
R2215	T3490	T3488	cc	and,annealed
R2216	T3491	T3488	conj	used,annealed
R2217	T3492	T3491	prep	for,used
R2218	T3493	T3494	det	the,reactions
R2219	T3494	T3492	pobj	reactions,for
R2220	T3495	T3491	punct	: ,used
R2221	T3496	T3497	compound	Csrp1,MRE1
R2222	T3497	T3491	dobj	MRE1,used
R2223	T3498	T3497	punct	: ,MRE1
R2224	T3499	T3500	nummod	5,GGAAACAAAACGGCGCGCACTCCGGCGC
R2225	T3500	T3497	appos	GGAAACAAAACGGCGCGCACTCCGGCGC,MRE1
R2226	T3501	T3499	punct	′,5
R2227	T3502	T3500	punct	-,GGAAACAAAACGGCGCGCACTCCGGCGC
R2228	T3503	T3500	punct	-,GGAAACAAAACGGCGCGCACTCCGGCGC
R2229	T3504	T3500	nummod	3,GGAAACAAAACGGCGCGCACTCCGGCGC
R2230	T3505	T3500	punct	′,GGAAACAAAACGGCGCGCACTCCGGCGC
R2231	T3506	T3500	punct	;,GGAAACAAAACGGCGCGCACTCCGGCGC
R2232	T3507	T3508	nummod	5,CGGAGTGCGCGCCGTTTTGT
R2233	T3508	T3500	appos	CGGAGTGCGCGCCGTTTTGT,GGAAACAAAACGGCGCGCACTCCGGCGC
R2234	T3509	T3507	punct	′,5
R2235	T3510	T3508	punct	-,CGGAGTGCGCGCCGTTTTGT
R2236	T3511	T3508	compound	GGCTGCGC,CGGAGTGCGCGCCGTTTTGT
R2237	T3512	T3508	punct	-,CGGAGTGCGCGCCGTTTTGT
R2238	T3513	T3508	nummod	3,CGGAGTGCGCGCCGTTTTGT
R2239	T3514	T3508	punct	′,CGGAGTGCGCGCCGTTTTGT
R2240	T3515	T3497	punct	", ",MRE1
R2241	T3516	T3517	compound	Csrp1,MRE2
R2242	T3517	T3497	appos	MRE2,MRE1
R2243	T3518	T3517	punct	: ,MRE2
R2244	T3519	T3520	nummod	5,TGTTGTGGTGCAGTGTGCAAAGCCTAC
R2245	T3520	T3517	appos	TGTTGTGGTGCAGTGTGCAAAGCCTAC,MRE2
R2246	T3521	T3519	punct	′,5
R2247	T3522	T3520	punct	-,TGTTGTGGTGCAGTGTGCAAAGCCTAC
R2248	T3523	T3520	punct	-,TGTTGTGGTGCAGTGTGCAAAGCCTAC
R2249	T3524	T3520	nummod	3,TGTTGTGGTGCAGTGTGCAAAGCCTAC
R2250	T3525	T3520	punct	′,TGTTGTGGTGCAGTGTGCAAAGCCTAC
R2251	T3526	T3520	punct	;,TGTTGTGGTGCAGTGTGCAAAGCCTAC
R2252	T3527	T3528	nummod	5,ACCAGTAGGCTTTGCACACTGCACCAC
R2253	T3528	T3520	appos	ACCAGTAGGCTTTGCACACTGCACCAC,TGTTGTGGTGCAGTGTGCAAAGCCTAC
R2254	T3529	T3527	punct	′,5
R2255	T3530	T3528	punct	-,ACCAGTAGGCTTTGCACACTGCACCAC
R2256	T3531	T3528	punct	-,ACCAGTAGGCTTTGCACACTGCACCAC
R2257	T3532	T3528	nummod	3,ACCAGTAGGCTTTGCACACTGCACCAC
R2258	T3533	T3528	punct	′,ACCAGTAGGCTTTGCACACTGCACCAC
R2259	T3534	T3497	punct	", ",MRE1
R2260	T3535	T3536	compound	Csrp1,MRE3
R2261	T3536	T3497	appos	MRE3,MRE1
R2262	T3537	T3536	punct	: ,MRE3
R2263	T3538	T3539	nummod	5,GAGATCGCCATAGGGTGCAAAGAGAAG
R2264	T3539	T3536	appos	GAGATCGCCATAGGGTGCAAAGAGAAG,MRE3
R2265	T3540	T3538	punct	′,5
R2266	T3541	T3539	punct	-,GAGATCGCCATAGGGTGCAAAGAGAAG
R2267	T3542	T3539	punct	-,GAGATCGCCATAGGGTGCAAAGAGAAG
R2268	T3543	T3539	nummod	3,GAGATCGCCATAGGGTGCAAAGAGAAG
R2269	T3544	T3539	punct	′,GAGATCGCCATAGGGTGCAAAGAGAAG
R2270	T3545	T3539	punct	;,GAGATCGCCATAGGGTGCAAAGAGAAG
R2271	T3546	T3547	nummod	5,GTGACTTCTCTTTGCACCCTATGGCGA
R2272	T3547	T3539	appos	GTGACTTCTCTTTGCACCCTATGGCGA,GAGATCGCCATAGGGTGCAAAGAGAAG
R2273	T3548	T3546	punct	′,5
R2274	T3549	T3547	punct	-,GTGACTTCTCTTTGCACCCTATGGCGA
R2275	T3550	T3547	punct	-,GTGACTTCTCTTTGCACCCTATGGCGA
R2276	T3551	T3547	nummod	3,GTGACTTCTCTTTGCACCCTATGGCGA
R2277	T3552	T3547	punct	′,GTGACTTCTCTTTGCACCCTATGGCGA
R2278	T3553	T3497	punct	", ",MRE1
R2279	T3554	T3555	compound	Csrp1,MRE4
R2280	T3555	T3497	appos	MRE4,MRE1
R2281	T3556	T3555	punct	: ,MRE4
R2282	T3557	T3558	nummod	5,TGTCTTATTCTGGAGTGCAAGTTAGTC
R2283	T3558	T3555	appos	TGTCTTATTCTGGAGTGCAAGTTAGTC,MRE4
R2284	T3559	T3557	punct	′,5
R2285	T3560	T3558	punct	-,TGTCTTATTCTGGAGTGCAAGTTAGTC
R2286	T3561	T3558	punct	-,TGTCTTATTCTGGAGTGCAAGTTAGTC
R2287	T3562	T3558	nummod	3,TGTCTTATTCTGGAGTGCAAGTTAGTC
R2288	T3563	T3558	punct	′,TGTCTTATTCTGGAGTGCAAGTTAGTC
R2289	T3564	T3558	punct	;,TGTCTTATTCTGGAGTGCAAGTTAGTC
R2290	T3565	T3566	nummod	5,AGGGGACTAACTTGCACTCCAGAATAA
R2291	T3566	T3558	appos	AGGGGACTAACTTGCACTCCAGAATAA,TGTCTTATTCTGGAGTGCAAGTTAGTC
R2292	T3567	T3565	punct	′,5
R2293	T3568	T3566	punct	-,AGGGGACTAACTTGCACTCCAGAATAA
R2294	T3569	T3566	punct	-,AGGGGACTAACTTGCACTCCAGAATAA
R2295	T3570	T3566	nummod	3,AGGGGACTAACTTGCACTCCAGAATAA
R2296	T3571	T3566	punct	′,AGGGGACTAACTTGCACTCCAGAATAA
R2297	T3572	T3497	punct	", ",MRE1
R2298	T3573	T3497	appos	Gal4,MRE1
R2299	T3574	T3573	punct	: ,Gal4
R2300	T3575	T3576	nummod	5,TCCGGAGGACTGTCCTCCGG
R2301	T3576	T3573	appos	TCCGGAGGACTGTCCTCCGG,Gal4
R2302	T3577	T3575	punct	′,5
R2303	T3578	T3576	punct	-,TCCGGAGGACTGTCCTCCGG
R2304	T3579	T3576	punct	-,TCCGGAGGACTGTCCTCCGG
R2305	T3580	T3576	nummod	3,TCCGGAGGACTGTCCTCCGG
R2306	T3581	T3576	punct	′,TCCGGAGGACTGTCCTCCGG
R2307	T3582	T3576	punct	;,TCCGGAGGACTGTCCTCCGG
R2308	T3583	T3584	nummod	5,GCCGGAGGACAGTCCTCCGG
R2309	T3584	T3576	appos	GCCGGAGGACAGTCCTCCGG,TCCGGAGGACTGTCCTCCGG
R2310	T3585	T3583	punct	′,5
R2311	T3586	T3584	punct	-,GCCGGAGGACAGTCCTCCGG
R2312	T3587	T3584	punct	-,GCCGGAGGACAGTCCTCCGG
R2313	T3588	T3584	nummod	3,GCCGGAGGACAGTCCTCCGG
R2314	T3589	T3584	punct	′,GCCGGAGGACAGTCCTCCGG
R2315	T3590	T3497	punct	", ",MRE1
R2316	T3591	T3497	appos	MREd,MRE1
R2317	T3592	T3591	punct	[,MREd
R2318	T3593	T3591	appos	MRE,MREd
R2319	T3594	T3593	acl	derived,MRE
R2320	T3595	T3594	prep	from,derived
R2321	T3596	T3597	compound	mouse,promoter
R2322	T3597	T3595	pobj	promoter,from
R2323	T3598	T3597	compound	Mt1,promoter
R2324	T3599	T3600	punct	(,10
R2325	T3600	T3594	parataxis	10,derived
R2326	T3601	T3600	punct	),10
R2327	T3602	T3591	punct	],MREd
R2328	T3603	T3591	punct	: ,MREd
R2329	T3604	T3605	nummod	5,CGAGGGAGCTCTGCACTCCGCCCGAAAAGTG
R2330	T3605	T3591	appos	CGAGGGAGCTCTGCACTCCGCCCGAAAAGTG,MREd
R2331	T3606	T3604	punct	′,5
R2332	T3607	T3605	punct	-,CGAGGGAGCTCTGCACTCCGCCCGAAAAGTG
R2333	T3608	T3605	punct	-,CGAGGGAGCTCTGCACTCCGCCCGAAAAGTG
R2334	T3609	T3605	nummod	3,CGAGGGAGCTCTGCACTCCGCCCGAAAAGTG
R2335	T3610	T3605	punct	′,CGAGGGAGCTCTGCACTCCGCCCGAAAAGTG
R2336	T3611	T3605	punct	;,CGAGGGAGCTCTGCACTCCGCCCGAAAAGTG
R2337	T3612	T3613	nummod	5,TCGACACTTTTCGGGCGGAGTGCAGAGCTCCCTCGAGCT
R2338	T3613	T3605	appos	TCGACACTTTTCGGGCGGAGTGCAGAGCTCCCTCGAGCT,CGAGGGAGCTCTGCACTCCGCCCGAAAAGTG
R2339	T3614	T3612	punct	′,5
R2340	T3615	T3613	punct	-,TCGACACTTTTCGGGCGGAGTGCAGAGCTCCCTCGAGCT
R2341	T3616	T3613	punct	-,TCGACACTTTTCGGGCGGAGTGCAGAGCTCCCTCGAGCT
R2342	T3617	T3613	nummod	3,TCGACACTTTTCGGGCGGAGTGCAGAGCTCCCTCGAGCT
R2343	T3618	T3613	punct	′,TCGACACTTTTCGGGCGGAGTGCAGAGCTCCCTCGAGCT
R2344	T3619	T3497	punct	", ",MRE1
R2345	T3620	T3621	compound	MRE,s
R2346	T3621	T3497	appos	s,MRE1
R2347	T3622	T3621	punct	-,s
R2348	T3623	T3621	punct	[,s
R2349	T3624	T3625	amod	synthetic,sequence
R2350	T3625	T3621	appos	sequence,s
R2351	T3626	T3625	compound	MRE,sequence
R2352	T3627	T3625	compound	consensus,sequence
R2353	T3628	T3629	punct	(,10
R2354	T3629	T3625	parataxis	10,sequence
R2355	T3630	T3629	punct	),10
R2356	T3631	T3621	punct	],s
R2357	T3632	T3621	punct	: ,s
R2358	T3633	T3634	nummod	5,CGAGGGAGCTCTGCACACGGCCCGAAAAGTG
R2359	T3634	T3621	appos	CGAGGGAGCTCTGCACACGGCCCGAAAAGTG,s
R2360	T3635	T3633	punct	′,5
R2361	T3636	T3634	punct	-,CGAGGGAGCTCTGCACACGGCCCGAAAAGTG
R2362	T3637	T3634	punct	-,CGAGGGAGCTCTGCACACGGCCCGAAAAGTG
R2363	T3638	T3634	nummod	3,CGAGGGAGCTCTGCACACGGCCCGAAAAGTG
R2364	T3639	T3634	punct	′,CGAGGGAGCTCTGCACACGGCCCGAAAAGTG
R2365	T3640	T3634	punct	;,CGAGGGAGCTCTGCACACGGCCCGAAAAGTG
R2366	T3641	T3642	nummod	5,TCGACACTTTTCGGGCCGTGTGCAGAGCTCCCTCGAGCT
R2367	T3642	T3634	appos	TCGACACTTTTCGGGCCGTGTGCAGAGCTCCCTCGAGCT,CGAGGGAGCTCTGCACACGGCCCGAAAAGTG
R2368	T3643	T3641	punct	′,5
R2369	T3644	T3642	punct	-,TCGACACTTTTCGGGCCGTGTGCAGAGCTCCCTCGAGCT
R2370	T3645	T3642	punct	-,TCGACACTTTTCGGGCCGTGTGCAGAGCTCCCTCGAGCT
R2371	T3646	T3642	nummod	3,TCGACACTTTTCGGGCCGTGTGCAGAGCTCCCTCGAGCT
R2372	T3647	T3642	punct	′,TCGACACTTTTCGGGCCGTGTGCAGAGCTCCCTCGAGCT
R2373	T3648	T3497	punct	", ",MRE1
R2374	T3649	T3650	compound	Ndrg1,MRE1
R2375	T3650	T3497	appos	MRE1,MRE1
R2376	T3651	T3650	punct	: ,MRE1
R2377	T3652	T3653	nummod	5,CAGCCCAGGCAGGGTGCAGCACGAG
R2378	T3653	T3650	appos	CAGCCCAGGCAGGGTGCAGCACGAG,MRE1
R2379	T3654	T3652	punct	′,5
R2380	T3655	T3653	punct	-,CAGCCCAGGCAGGGTGCAGCACGAG
R2381	T3656	T3653	punct	-,CAGCCCAGGCAGGGTGCAGCACGAG
R2382	T3657	T3653	nummod	3,CAGCCCAGGCAGGGTGCAGCACGAG
R2383	T3658	T3653	punct	′,CAGCCCAGGCAGGGTGCAGCACGAG
R2384	T3659	T3653	punct	;,CAGCCCAGGCAGGGTGCAGCACGAG
R2385	T3660	T3661	nummod	5,CCGCCTCGTGCTGCACCCTGCCTGG
R2386	T3661	T3653	appos	CCGCCTCGTGCTGCACCCTGCCTGG,CAGCCCAGGCAGGGTGCAGCACGAG
R2387	T3662	T3660	punct	′,5
R2388	T3663	T3661	punct	-,CCGCCTCGTGCTGCACCCTGCCTGG
R2389	T3664	T3661	punct	-,CCGCCTCGTGCTGCACCCTGCCTGG
R2390	T3665	T3661	nummod	3,CCGCCTCGTGCTGCACCCTGCCTGG
R2391	T3666	T3661	punct	′,CCGCCTCGTGCTGCACCCTGCCTGG
R2392	T3667	T3497	punct	", ",MRE1
R2393	T3668	T3669	compound	Ndrg1,MRE2
R2394	T3669	T3497	appos	MRE2,MRE1
R2395	T3670	T3669	punct	: ,MRE2
R2396	T3671	T3672	nummod	5,CACACGTTCGCTGCACACGCCGCGG
R2397	T3672	T3669	appos	CACACGTTCGCTGCACACGCCGCGG,MRE2
R2398	T3673	T3671	punct	′,5
R2399	T3674	T3672	punct	-,CACACGTTCGCTGCACACGCCGCGG
R2400	T3675	T3672	punct	-,CACACGTTCGCTGCACACGCCGCGG
R2401	T3676	T3672	nummod	3,CACACGTTCGCTGCACACGCCGCGG
R2402	T3677	T3672	punct	′,CACACGTTCGCTGCACACGCCGCGG
R2403	T3678	T3672	punct	;,CACACGTTCGCTGCACACGCCGCGG
R2404	T3679	T3680	nummod	5,GGGACCGCGGCGTGTGCAGCGAACG
R2405	T3680	T3672	appos	GGGACCGCGGCGTGTGCAGCGAACG,CACACGTTCGCTGCACACGCCGCGG
R2406	T3681	T3679	punct	′,5
R2407	T3682	T3680	punct	-,GGGACCGCGGCGTGTGCAGCGAACG
R2408	T3683	T3680	punct	-,GGGACCGCGGCGTGTGCAGCGAACG
R2409	T3684	T3680	nummod	3,GGGACCGCGGCGTGTGCAGCGAACG
R2410	T3685	T3680	punct	′,GGGACCGCGGCGTGTGCAGCGAACG
R2411	T3686	T3497	punct	", ",MRE1
R2412	T3687	T3688	compound	Ndrg1,MRE3
R2413	T3688	T3497	appos	MRE3,MRE1
R2414	T3689	T3688	punct	",",MRE3
R2415	T3690	T3688	nummod	4,MRE3
R2416	T3691	T3688	punct	: ,MRE3
R2417	T3692	T3693	nummod	5,GGAGTCCTTATGCACACGCGCACGAGCGCGCACGGGCAC
R2418	T3693	T3688	appos	GGAGTCCTTATGCACACGCGCACGAGCGCGCACGGGCAC,MRE3
R2419	T3694	T3692	punct	′,5
R2420	T3695	T3693	punct	-,GGAGTCCTTATGCACACGCGCACGAGCGCGCACGGGCAC
R2421	T3696	T3693	punct	-,GGAGTCCTTATGCACACGCGCACGAGCGCGCACGGGCAC
R2422	T3697	T3693	nummod	3,GGAGTCCTTATGCACACGCGCACGAGCGCGCACGGGCAC
R2423	T3698	T3693	punct	′,GGAGTCCTTATGCACACGCGCACGAGCGCGCACGGGCAC
R2424	T3699	T3693	punct	;,GGAGTCCTTATGCACACGCGCACGAGCGCGCACGGGCAC
R2425	T3700	T3701	nummod	5,TGGTGTGCCCGTGCGCGCTCGTGCGCGTGTGCATAAGGAC
R2426	T3701	T3693	appos	TGGTGTGCCCGTGCGCGCTCGTGCGCGTGTGCATAAGGAC,GGAGTCCTTATGCACACGCGCACGAGCGCGCACGGGCAC
R2427	T3702	T3700	punct	′,5
R2428	T3703	T3701	punct	-,TGGTGTGCCCGTGCGCGCTCGTGCGCGTGTGCATAAGGAC
R2429	T3704	T3701	punct	-,TGGTGTGCCCGTGCGCGCTCGTGCGCGTGTGCATAAGGAC
R2430	T3705	T3701	nummod	3,TGGTGTGCCCGTGCGCGCTCGTGCGCGTGTGCATAAGGAC
R2431	T3706	T3701	punct	′,TGGTGTGCCCGTGCGCGCTCGTGCGCGTGTGCATAAGGAC
R2432	T3707	T3497	punct	", ",MRE1
R2433	T3708	T3709	compound	Sepw1,MRE1
R2434	T3709	T3497	appos	MRE1,MRE1
R2435	T3710	T3709	punct	: ,MRE1
R2436	T3711	T3712	nummod	5,GAGGCAGTCGGCTGTGCGCACGGCCCCACGCTC
R2437	T3712	T3709	appos	GAGGCAGTCGGCTGTGCGCACGGCCCCACGCTC,MRE1
R2438	T3713	T3711	punct	′,5
R2439	T3714	T3712	punct	-,GAGGCAGTCGGCTGTGCGCACGGCCCCACGCTC
R2440	T3715	T3712	punct	-,GAGGCAGTCGGCTGTGCGCACGGCCCCACGCTC
R2441	T3716	T3712	nummod	3,GAGGCAGTCGGCTGTGCGCACGGCCCCACGCTC
R2442	T3717	T3712	punct	′,GAGGCAGTCGGCTGTGCGCACGGCCCCACGCTC
R2443	T3718	T3712	punct	;,GAGGCAGTCGGCTGTGCGCACGGCCCCACGCTC
R2444	T3719	T3720	nummod	5,CTCTGAGCGTGGGGCCGTGCGCACAGCCGACTGC
R2445	T3720	T3712	appos	CTCTGAGCGTGGGGCCGTGCGCACAGCCGACTGC,GAGGCAGTCGGCTGTGCGCACGGCCCCACGCTC
R2446	T3721	T3719	punct	′,5
R2447	T3722	T3720	punct	-,CTCTGAGCGTGGGGCCGTGCGCACAGCCGACTGC
R2448	T3723	T3720	punct	-,CTCTGAGCGTGGGGCCGTGCGCACAGCCGACTGC
R2449	T3724	T3720	nummod	3,CTCTGAGCGTGGGGCCGTGCGCACAGCCGACTGC
R2450	T3725	T3720	punct	′,CTCTGAGCGTGGGGCCGTGCGCACAGCCGACTGC
R2451	T3726	T3497	punct	", ",MRE1
R2452	T3727	T3728	compound	Sepw1,MRE2
R2453	T3728	T3497	appos	MRE2,MRE1
R2454	T3729	T3728	punct	: ,MRE2
R2455	T3730	T3731	nummod	5,ATGGTTTTGGGGGTGCGCAGGGGGTCTG
R2456	T3731	T3728	appos	ATGGTTTTGGGGGTGCGCAGGGGGTCTG,MRE2
R2457	T3732	T3730	punct	′,5
R2458	T3733	T3731	punct	-,ATGGTTTTGGGGGTGCGCAGGGGGTCTG
R2459	T3734	T3731	punct	-,ATGGTTTTGGGGGTGCGCAGGGGGTCTG
R2460	T3735	T3731	nummod	3,ATGGTTTTGGGGGTGCGCAGGGGGTCTG
R2461	T3736	T3731	punct	′,ATGGTTTTGGGGGTGCGCAGGGGGTCTG
R2462	T3737	T3731	punct	;,ATGGTTTTGGGGGTGCGCAGGGGGTCTG
R2463	T3738	T3739	nummod	5,CGACAGACCCCCTGCGCACCCCCAAAAC
R2464	T3739	T3731	appos	CGACAGACCCCCTGCGCACCCCCAAAAC,ATGGTTTTGGGGGTGCGCAGGGGGTCTG
R2465	T3740	T3738	punct	′,5
R2466	T3741	T3739	punct	-,CGACAGACCCCCTGCGCACCCCCAAAAC
R2467	T3742	T3739	punct	-,CGACAGACCCCCTGCGCACCCCCAAAAC
R2468	T3743	T3739	nummod	3,CGACAGACCCCCTGCGCACCCCCAAAAC
R2469	T3744	T3739	punct	′,CGACAGACCCCCTGCGCACCCCCAAAAC
R2470	T3745	T3497	punct	", ",MRE1
R2471	T3746	T3747	compound	Slc39a10,MRE1
R2472	T3747	T3497	appos	MRE1,MRE1
R2473	T3748	T3747	punct	: ,MRE1
R2474	T3749	T3750	nummod	5,GAATACACGACTGGGTGCAGCCGGGGTTTGG
R2475	T3750	T3747	appos	GAATACACGACTGGGTGCAGCCGGGGTTTGG,MRE1
R2476	T3751	T3749	punct	′,5
R2477	T3752	T3750	punct	-,GAATACACGACTGGGTGCAGCCGGGGTTTGG
R2478	T3753	T3750	punct	-,GAATACACGACTGGGTGCAGCCGGGGTTTGG
R2479	T3754	T3750	nummod	3,GAATACACGACTGGGTGCAGCCGGGGTTTGG
R2480	T3755	T3750	punct	′,GAATACACGACTGGGTGCAGCCGGGGTTTGG
R2481	T3756	T3750	punct	;,GAATACACGACTGGGTGCAGCCGGGGTTTGG
R2482	T3757	T3758	nummod	5,GGTACCAAACCCCGGCTGCACCCAGTCGTGTA
R2483	T3758	T3750	appos	GGTACCAAACCCCGGCTGCACCCAGTCGTGTA,GAATACACGACTGGGTGCAGCCGGGGTTTGG
R2484	T3759	T3757	punct	′,5
R2485	T3760	T3758	punct	-,GGTACCAAACCCCGGCTGCACCCAGTCGTGTA
R2486	T3761	T3758	punct	-,GGTACCAAACCCCGGCTGCACCCAGTCGTGTA
R2487	T3762	T3758	nummod	3,GGTACCAAACCCCGGCTGCACCCAGTCGTGTA
R2488	T3763	T3758	punct	′,GGTACCAAACCCCGGCTGCACCCAGTCGTGTA
R2489	T3764	T3497	punct	", ",MRE1
R2490	T3765	T3766	compound	Slc39a10,MRE2
R2491	T3766	T3497	appos	MRE2,MRE1
R2492	T3767	T3766	punct	: ,MRE2
R2493	T3768	T3769	nummod	5,GCGGAGAGGAGATGCACACGGCACTCG
R2494	T3769	T3766	appos	GCGGAGAGGAGATGCACACGGCACTCG,MRE2
R2495	T3770	T3768	punct	′,5
R2496	T3771	T3769	punct	-,GCGGAGAGGAGATGCACACGGCACTCG
R2497	T3772	T3769	punct	-,GCGGAGAGGAGATGCACACGGCACTCG
R2498	T3773	T3769	nummod	3,GCGGAGAGGAGATGCACACGGCACTCG
R2499	T3774	T3769	punct	′,GCGGAGAGGAGATGCACACGGCACTCG
R2500	T3775	T3769	punct	;,GCGGAGAGGAGATGCACACGGCACTCG
R2501	T3776	T3777	nummod	5,CACTCGAGTGCCGTGTGCATCTCCTCT
R2502	T3777	T3769	appos	CACTCGAGTGCCGTGTGCATCTCCTCT,GCGGAGAGGAGATGCACACGGCACTCG
R2503	T3778	T3776	punct	′,5
R2504	T3779	T3777	punct	-,CACTCGAGTGCCGTGTGCATCTCCTCT
R2505	T3780	T3777	punct	-,CACTCGAGTGCCGTGTGCATCTCCTCT
R2506	T3781	T3777	nummod	3,CACTCGAGTGCCGTGTGCATCTCCTCT
R2507	T3782	T3777	punct	′,CACTCGAGTGCCGTGTGCATCTCCTCT
R2508	T3783	T3497	punct	", ",MRE1
R2509	T3784	T3785	nmod	Specificity,protein
R2510	T3785	T3786	nmod	protein,sequence
R2511	T3786	T3497	appos	sequence,MRE1
R2512	T3787	T3785	nummod	1,protein
R2513	T3788	T3785	punct	(,protein
R2514	T3789	T3785	appos	Sp1,protein
R2515	T3790	T3786	punct	),sequence
R2516	T3791	T3786	compound	binding,sequence
R2517	T3792	T3793	punct	(,10
R2518	T3793	T3786	parataxis	10,sequence
R2519	T3794	T3793	punct	),10
R2520	T3795	T3497	punct	: ,MRE1
R2521	T3796	T3797	nummod	5,CGAGGCCCCGCCCAG
R2522	T3797	T3497	appos	CGAGGCCCCGCCCAG,MRE1
R2523	T3798	T3796	punct	′,5
R2524	T3799	T3797	punct	-,CGAGGCCCCGCCCAG
R2525	T3800	T3797	punct	-,CGAGGCCCCGCCCAG
R2526	T3801	T3797	nummod	3,CGAGGCCCCGCCCAG
R2527	T3802	T3797	punct	′,CGAGGCCCCGCCCAG
R2528	T3803	T3797	punct	;,CGAGGCCCCGCCCAG
R2529	T3804	T3805	nummod	5,TCGACTGGGCGGGGCCTCGAGct
R2530	T3805	T3797	appos	TCGACTGGGCGGGGCCTCGAGct,CGAGGCCCCGCCCAG
R2531	T3806	T3804	punct	′,5
R2532	T3807	T3805	punct	-,TCGACTGGGCGGGGCCTCGAGct
R2533	T3808	T3805	punct	-,TCGACTGGGCGGGGCCTCGAGct
R2534	T3809	T3805	nummod	3,TCGACTGGGCGGGGCCTCGAGct
R2535	T3810	T3805	punct	′,TCGACTGGGCGGGGCCTCGAGct
R2536	T3811	T3488	punct	.,annealed
R2537	T3873	T3888	compound	Mtf1loxP,embryo
R2538	T3874	T3898	conj	streptomycin,serum
R2539	T3875	T3876	compound	Cell,culture
R2540	T3878	T3879	amod	Primary,fibroblasts
R2541	T3879	T3881	nsubjpass	fibroblasts,isolated
R2542	T3880	T3879	amod	embryonic,fibroblasts
R2543	T3882	T3881	auxpass	were,isolated
R2544	T3883	T3881	prep	from,isolated
R2545	T3884	T3885	det	a,day
R2546	T3885	T3887	npadvmod	day,old
R2547	T3886	T3885	nummod	12.5,day
R2548	T3887	T3888	amod	old,embryo
R2549	T3888	T3883	pobj	embryo,from
R2550	T3889	T3888	compound	mouse,embryo
R2551	T3890	T3881	cc	and,isolated
R2552	T3891	T3881	conj	grown,isolated
R2553	T3892	T3891	prep	in,grown
R2554	T3893	T3892	pobj	DMEM,in
R2555	T3894	T3893	acl	supplemented,DMEM
R2556	T3895	T3894	prep	with,supplemented
R2557	T3896	T3897	nummod	10,%
R2558	T3897	T3898	nmod	%,serum
R2559	T3898	T3895	pobj	serum,with
R2560	T3899	T3898	amod	fetal,serum
R2561	T3900	T3898	amod	bovine,serum
R2562	T3901	T3902	punct	(,ICN
R2563	T3902	T3898	parataxis	ICN,serum
R2564	T3903	T3902	punct	),ICN
R2565	T3904	T3898	punct	", ",serum
R2566	T3905	T3906	nummod	100,U
R2567	T3906	T3874	nmod	U,streptomycin
R2568	T3907	T3908	punct	/,ml
R2569	T3908	T3906	prep	ml,U
R2570	T3909	T3874	compound	penicillin,streptomycin
R2571	T3910	T3874	punct	–,streptomycin
R2572	T3911	T3912	punct	(,BRL
R2573	T3912	T3874	parataxis	BRL,streptomycin
R2574	T3913	T3912	compound	Gibco,BRL
R2575	T3914	T3912	punct	),BRL
R2576	T3915	T3874	cc	and,streptomycin
R2577	T3916	T3917	nummod	2,mM
R2578	T3917	T3918	compound	mM,glutamine
R2579	T3918	T3874	conj	glutamine,streptomycin
R2580	T3919	T3918	compound	l,glutamine
R2581	T3920	T3918	punct	-,glutamine
R2582	T3921	T3922	punct	(,BRL
R2583	T3922	T3918	parataxis	BRL,glutamine
R2584	T3923	T3922	compound	Gibco,BRL
R2585	T3924	T3922	punct	),BRL
R2586	T3925	T3881	punct	.,isolated
R2587	T3927	T3928	nummod	100,mm
R2588	T3928	T3929	compound	mm,plates
R2589	T3929	T3930	nsubjpass	plates,transfected
R2590	T3931	T3929	prep	with,plates
R2591	T3932	T3933	amod	primary,cells
R2592	T3933	T3931	pobj	cells,with
R2593	T3934	T3930	auxpass	were,transfected
R2594	T3935	T3930	prep	with,transfected
R2595	T3936	T3937	nummod	10,µg
R2596	T3937	T3935	pobj	µg,with
R2597	T3938	T3937	prep	of,µg
R2598	T3939	T3940	det	an,plasmid
R2599	T3940	T3938	pobj	plasmid,of
R2600	T3941	T3940	compound	expression,plasmid
R2601	T3942	T3940	acl	coding,plasmid
R2602	T3943	T3942	prep	for,coding
R2603	T3944	T3945	amod	simian,virus
R2604	T3945	T3946	nmod	virus,antigen
R2605	T3946	T3943	pobj	antigen,for
R2606	T3947	T3945	nummod	40,virus
R2607	T3948	T3945	punct	(,virus
R2608	T3949	T3945	appos	SV40,virus
R2609	T3950	T3946	punct	),antigen
R2610	T3951	T3952	amod	large,T
R2611	T3952	T3946	compound	T,antigen
R2612	T3953	T3946	acl	driven,antigen
R2613	T3954	T3953	agent	by,driven
R2614	T3955	T3956	det	the,promoter
R2615	T3956	T3954	pobj	promoter,by
R2616	T3957	T3956	nmod	cytomegalovirus,promoter
R2617	T3958	T3957	punct	(,cytomegalovirus
R2618	T3959	T3957	appos	CMV,cytomegalovirus
R2619	T3960	T3956	punct	),promoter
R2620	T3961	T3930	punct	", ",transfected
R2621	T3962	T3930	advcl	using,transfected
R2622	T3963	T3964	nmod	lipofectamine,reagent
R2623	T3964	T3962	dobj	reagent,using
R2624	T3965	T3963	punct	™,lipofectamine
R2625	T3966	T3967	punct	(,Invitrogen
R2626	T3967	T3964	parataxis	Invitrogen,reagent
R2627	T3968	T3967	punct	),Invitrogen
R2628	T3969	T3962	prep	according,using
R2629	T3970	T3969	prep	to,according
R2630	T3971	T3972	det	the,manufacturer
R2631	T3972	T3973	poss	manufacturer,instructions
R2632	T3973	T3970	pobj	instructions,to
R2633	T3974	T3972	case	's,manufacturer
R2634	T3975	T3930	punct	.,transfected
R2635	T3977	T3978	compound	Cell,foci
R2636	T3978	T3979	nsubjpass	foci,isolated
R2637	T3980	T3979	auxpass	were,isolated
R2638	T3981	T3979	cc	and,isolated
R2639	T3982	T3983	det	the,line
R2640	T3983	T3989	nsubjpass	line,derived
R2641	T3984	T3983	amod	immortalized,line
R2642	T3985	T3986	nmod	mouse,fibroblast
R2643	T3986	T3983	compound	fibroblast,line
R2644	T3987	T3986	amod	embryonic,fibroblast
R2645	T3988	T3983	compound	cell,line
R2646	T3989	T3979	conj	derived,isolated
R2647	T3990	T3983	appos	ckoC,line
R2648	T3991	T3989	auxpass	was,derived
R2649	T3992	T3989	prep	from,derived
R2650	T3993	T3992	pobj	one,from
R2651	T3994	T3993	prep	of,one
R2652	T3995	T3994	pobj	them,of
R2653	T3996	T3989	punct	.,derived
R2654	T3998	T3999	det	The,genotype
R2655	T3999	T4001	nsubjpass	genotype,confirmed
R2656	T4000	T3999	compound	Mtf1loxP,genotype
R2657	T4002	T3999	prep	of,genotype
R2658	T4003	T4004	det	this,line
R2659	T4004	T4002	pobj	line,of
R2660	T4005	T4006	advmod	as,as
R2661	T4006	T3999	cc	as,genotype
R2662	T4007	T4006	advmod	well,as
R2663	T4008	T4009	det	the,integration
R2664	T4009	T3999	conj	integration,genotype
R2665	T4010	T4009	amod	genomic,integration
R2666	T4011	T4009	prep	of,integration
R2667	T4012	T4013	det	the,antigen
R2668	T4013	T4011	pobj	antigen,of
R2669	T4014	T4013	compound	T,antigen
R2670	T4015	T4001	auxpass	were,confirmed
R2671	T4016	T4001	agent	by,confirmed
R2672	T4017	T4016	pobj	PCR,by
R2673	T4018	T4001	punct	.,confirmed
R2674	T4020	T4021	nummod	100,mm
R2675	T4021	T4022	compound	mm,plates
R2676	T4022	T4023	nsubjpass	plates,transfected
R2677	T4024	T4022	prep	with,plates
R2678	T4025	T4026	det	these,cells
R2679	T4026	T4024	pobj	cells,with
R2680	T4027	T4023	auxpass	were,transfected
R2681	T4028	T4023	advmod	further,transfected
R2682	T4029	T4023	agent	by,transfected
R2683	T4030	T4031	det	the,method
R2684	T4031	T4029	pobj	method,by
R2685	T4032	T4033	compound	calcium,phosphate
R2686	T4033	T4031	compound	phosphate,method
R2687	T4034	T4035	punct	(,30
R2688	T4035	T4031	parataxis	30,method
R2689	T4036	T4035	punct	),30
R2690	T4037	T4031	prep	with,method
R2691	T4038	T4039	nummod	19.6,µg
R2692	T4039	T4037	pobj	µg,with
R2693	T4040	T4039	prep	of,µg
R2694	T4041	T4042	det	an,plasmid
R2695	T4042	T4040	pobj	plasmid,of
R2696	T4043	T4042	compound	expression,plasmid
R2697	T4044	T4042	prep	for,plasmid
R2698	T4045	T4046	compound	Cre,recombinase
R2699	T4046	T4044	pobj	recombinase,for
R2700	T4047	T4042	acl	driven,plasmid
R2701	T4048	T4047	agent	by,driven
R2702	T4049	T4050	det	the,promoter
R2703	T4050	T4048	pobj	promoter,by
R2704	T4051	T4050	compound	CMV,promoter
R2705	T4052	T4039	cc	and,µg
R2706	T4053	T4054	nummod	0.4,µg
R2707	T4054	T4039	conj	µg,µg
R2708	T4055	T4054	prep	of,µg
R2709	T4056	T4057	det	an,plasmid
R2710	T4057	T4055	pobj	plasmid,of
R2711	T4058	T4057	compound	expression,plasmid
R2712	T4059	T4057	prep	for,plasmid
R2713	T4060	T4061	det	the,gene
R2714	T4061	T4059	pobj	gene,for
R2715	T4062	T4061	compound	neomycin,gene
R2716	T4063	T4061	compound	resistance,gene
R2717	T4064	T4061	prep	under,gene
R2718	T4065	T4066	det	the,control
R2719	T4066	T4064	pobj	control,under
R2720	T4067	T4066	prep	of,control
R2721	T4068	T4069	det	the,promoter
R2722	T4069	T4067	pobj	promoter,of
R2723	T4070	T4069	compound	TK,promoter
R2724	T4071	T4023	punct	.,transfected
R2725	T4073	T4074	advmod	Stably,transfected
R2726	T4074	T4075	amod	transfected,cells
R2727	T4075	T4076	nsubjpass	cells,selected
R2728	T4077	T4076	auxpass	were,selected
R2729	T4078	T4076	prep	in,selected
R2730	T4079	T4080	det	the,presence
R2731	T4080	T4078	pobj	presence,in
R2732	T4081	T4080	prep	of,presence
R2733	T4082	T4083	nummod	0.4,µg
R2734	T4083	T4084	nmod	µg,G418
R2735	T4084	T4081	pobj	G418,of
R2736	T4085	T4086	punct	/,µl
R2737	T4086	T4083	prep	µl,µg
R2738	T4087	T4088	punct	(,Calbiochem
R2739	T4088	T4084	parataxis	Calbiochem,G418
R2740	T4089	T4088	punct	),Calbiochem
R2741	T4090	T4076	punct	", ",selected
R2742	T4091	T4092	amod	isolated,clones
R2743	T4092	T4093	nsubjpass	clones,harvested
R2744	T4093	T4076	conj	harvested,selected
R2745	T4094	T4092	prep	of,clones
R2746	T4095	T4096	amod	resistant,cells
R2747	T4096	T4094	pobj	cells,of
R2748	T4097	T4093	auxpass	were,harvested
R2749	T4098	T4093	cc	and,harvested
R2750	T4099	T4093	conj	grown,harvested
R2751	T4100	T4099	advmod	independently,grown
R2752	T4101	T4093	punct	", ",harvested
R2753	T4102	T4093	cc	and,harvested
R2754	T4103	T4104	det	the,expression
R2755	T4104	T4105	nsubjpass	expression,analyzed
R2756	T4105	T4093	conj	analyzed,harvested
R2757	T4106	T4104	prep	of,expression
R2758	T4107	T4108	compound	Cre,recombinase
R2759	T4108	T4106	pobj	recombinase,of
R2760	T4109	T4104	cc	and,expression
R2761	T4110	T4104	conj	excision,expression
R2762	T4111	T4110	prep	of,excision
R2763	T4112	T4113	nmod	exons,3
R2764	T4113	T4111	pobj	3,of
R2765	T4114	T4113	cc	and,3
R2766	T4115	T4113	conj	4,3
R2767	T4116	T4113	prep	of,3
R2768	T4117	T4116	pobj	Mtf1,of
R2769	T4118	T4105	auxpass	were,analyzed
R2770	T4119	T4105	agent	by,analyzed
R2771	T4120	T4121	compound	RT,PCR
R2772	T4121	T4119	pobj	PCR,by
R2773	T4122	T4121	punct	–,PCR
R2774	T4123	T4105	punct	.,analyzed
R2775	T4125	T4126	det	The,lines
R2776	T4126	T4128	nsubjpass	lines,chosen
R2777	T4127	T4126	compound	cell,lines
R2778	T4129	T4126	appos	delC19,lines
R2779	T4130	T4129	punct	", ",delC19
R2780	T4131	T4129	conj	delC21,delC19
R2781	T4132	T4131	cc	and,delC21
R2782	T4133	T4131	conj	delC23,delC21
R2783	T4134	T4126	prep	with,lines
R2784	T4135	T4136	det	a,deletion
R2785	T4136	T4134	pobj	deletion,with
R2786	T4137	T4136	prep	of,deletion
R2787	T4138	T4137	pobj	Mtf1,of
R2788	T4139	T4128	auxpass	were,chosen
R2789	T4140	T4128	prep	for,chosen
R2790	T4141	T4142	amod	further,experiments
R2791	T4142	T4140	pobj	experiments,for
R2792	T4143	T4128	punct	.,chosen
R2795	T4279	T4280	compound	Cytotoxicity,assay
R2796	T4282	T4283	nsubjpass	Samples,plated
R2797	T4284	T4282	prep	of,Samples
R2798	T4285	T4286	quantmod	1,104
R2799	T4286	T4288	nummod	104,cells
R2800	T4287	T4286	punct	×,104
R2801	T4288	T4284	pobj	cells,of
R2802	T4289	T4290	punct	/,well
R2803	T4290	T4288	prep	well,cells
R2804	T4291	T4283	auxpass	were,plated
R2805	T4292	T4283	prep	in,plated
R2806	T4293	T4294	nummod	96,well
R2807	T4294	T4296	compound	well,plates
R2808	T4295	T4294	punct	-,well
R2809	T4296	T4292	pobj	plates,in
R2810	T4297	T4298	compound	tissue,culture
R2811	T4298	T4296	compound	culture,plates
R2812	T4299	T4283	cc	and,plated
R2813	T4300	T4283	conj	allowed,plated
R2814	T4301	T4302	aux	to,adhere
R2815	T4302	T4300	xcomp	adhere,allowed
R2816	T4303	T4302	prep	for,adhere
R2817	T4304	T4305	nummod	24,h
R2818	T4305	T4303	pobj	h,for
R2819	T4306	T4283	punct	.,plated
R2820	T4308	T4309	det	The,cells
R2821	T4309	T4310	nsubjpass	cells,pre-incubated
R2822	T4311	T4310	auxpass	were,pre-incubated
R2823	T4312	T4310	advmod	then,pre-incubated
R2824	T4313	T4310	prep	for,pre-incubated
R2825	T4314	T4315	nummod	24,h
R2826	T4315	T4313	pobj	h,for
R2827	T4316	T4310	prep	in,pre-incubated
R2828	T4317	T4316	pobj	medium,in
R2829	T4318	T4317	acl	containing,medium
R2830	T4319	T4320	nummod	0,µM
R2831	T4320	T4318	dobj	µM,containing
R2832	T4321	T4319	punct	", ",0
R2833	T4322	T4319	conj	5,0
R2834	T4323	T4322	punct	", ",5
R2835	T4324	T4322	conj	10,5
R2836	T4325	T4324	punct	", ",10
R2837	T4326	T4324	conj	25,10
R2838	T4327	T4326	cc	or,25
R2839	T4328	T4326	conj	50,25
R2840	T4329	T4330	nmod	l,sulfoximine
R2841	T4330	T4320	appos	sulfoximine,µM
R2842	T4331	T4330	punct	-,sulfoximine
R2843	T4332	T4330	nmod	buthionine,sulfoximine
R2844	T4333	T4330	punct	-,sulfoximine
R2845	T4334	T4330	punct	[,sulfoximine
R2846	T4335	T4330	nmod	S,sulfoximine
R2847	T4336	T4330	punct	",",sulfoximine
R2848	T4337	T4330	nmod	R,sulfoximine
R2849	T4338	T4330	punct	],sulfoximine
R2850	T4339	T4330	punct	-,sulfoximine
R2851	T4340	T4330	punct	(,sulfoximine
R2852	T4341	T4330	appos	BSO,sulfoximine
R2853	T4342	T4320	punct	),µM
R2854	T4343	T4344	punct	(,Sigma
R2855	T4344	T4320	parataxis	Sigma,µM
R2856	T4345	T4344	punct	),Sigma
R2857	T4346	T4320	punct	", ",µM
R2858	T4347	T4348	det	a,drug
R2859	T4348	T4320	appos	drug,µM
R2860	T4349	T4350	dep	that,inhibits
R2861	T4350	T4348	relcl	inhibits,drug
R2862	T4351	T4352	compound	glutathione,synthesis
R2863	T4352	T4350	dobj	synthesis,inhibits
R2864	T4353	T4354	punct	(,31
R2865	T4354	T4350	parataxis	31,inhibits
R2866	T4355	T4354	punct	),31
R2867	T4356	T4310	punct	.,pre-incubated
R2868	T4358	T4359	advmod	Later,exposed
R2869	T4360	T4359	punct	", ",exposed
R2870	T4361	T4359	nsubjpass	cells,exposed
R2871	T4362	T4359	auxpass	were,exposed
R2872	T4363	T4359	prep	to,exposed
R2873	T4364	T4365	nummod	0,µM
R2874	T4365	T4372	compound	µM,CdCl2
R2875	T4366	T4364	punct	", ",0
R2876	T4367	T4364	conj	5,0
R2877	T4368	T4367	punct	", ",5
R2878	T4369	T4367	conj	10,5
R2879	T4370	T4369	cc	or,10
R2880	T4371	T4369	conj	20,10
R2881	T4372	T4363	pobj	CdCl2,to
R2882	T4373	T4359	prep	in,exposed
R2883	T4374	T4375	det	the,medium
R2884	T4375	T4373	pobj	medium,in
R2885	T4376	T4375	amod	specified,medium
R2886	T4377	T4375	compound	pre-incubation,medium
R2887	T4378	T4359	prep	for,exposed
R2888	T4379	T4380	det	an,h
R2889	T4380	T4378	pobj	h,for
R2890	T4381	T4380	amod	additional,h
R2891	T4382	T4380	nummod	24,h
R2892	T4383	T4359	punct	.,exposed
R2893	T4385	T4386	nsubjpass	Cytotoxicity,determined
R2894	T4387	T4386	auxpass	was,determined
R2895	T4388	T4386	agent	by,determined
R2896	T4389	T4390	det	the,Kit
R2897	T4390	T4388	pobj	Kit,by
R2898	T4391	T4392	npadvmod	MTT,based
R2899	T4392	T4390	amod	based,Kit
R2900	T4393	T4394	punct	(,bromid
R2901	T4394	T4391	parataxis	bromid,MTT
R2902	T4395	T4396	nummod	3,dimethylthiazol
R2903	T4396	T4394	nmod	dimethylthiazol,bromid
R2904	T4397	T4396	punct	-,dimethylthiazol
R2905	T4398	T4396	punct	[,dimethylthiazol
R2906	T4399	T4396	nummod	4,dimethylthiazol
R2907	T4400	T4396	punct	",",dimethylthiazol
R2908	T4401	T4396	nummod	5,dimethylthiazol
R2909	T4402	T4396	punct	-,dimethylthiazol
R2910	T4403	T4396	punct	-,dimethylthiazol
R2911	T4404	T4405	nummod	2,yl
R2912	T4405	T4396	appos	yl,dimethylthiazol
R2913	T4406	T4405	punct	-,yl
R2914	T4407	T4396	punct	],dimethylthiazol
R2915	T4408	T4396	punct	-,dimethylthiazol
R2916	T4409	T4396	nummod	2,dimethylthiazol
R2917	T4410	T4394	punct	",",bromid
R2918	T4411	T4412	nummod	5,diphenyl
R2919	T4412	T4394	compound	diphenyl,bromid
R2920	T4413	T4412	punct	-,diphenyl
R2921	T4414	T4394	compound	tetrazolium,bromid
R2922	T4415	T4394	punct	),bromid
R2923	T4416	T4392	punct	-,based
R2924	T4417	T4390	compound	Cell,Kit
R2925	T4418	T4390	compound	Proliferation,Kit
R2926	T4419	T4390	nummod	I,Kit
R2927	T4420	T4421	punct	(,Roche
R2928	T4421	T4390	parataxis	Roche,Kit
R2929	T4422	T4421	punct	),Roche
R2930	T4423	T4386	prep	according,determined
R2931	T4424	T4423	prep	to,according
R2932	T4425	T4426	det	the,manufacturer
R2933	T4426	T4427	poss	manufacturer,instructions
R2934	T4427	T4424	pobj	instructions,to
R2935	T4428	T4426	case	's,manufacturer
R2936	T4429	T4386	punct	.,determined
R2939	T4680	T4679	prep	of,Generation
R2940	T4681	T4682	det	an,line
R2941	T4682	T4680	pobj	line,of
R2942	T4683	T4682	amod	inducible,line
R2943	T4684	T4682	punct	", ",line
R2944	T4685	T4686	npadvmod	liver,specific
R2945	T4686	T4682	amod	specific,line
R2946	T4687	T4686	punct	-,specific
R2947	T4688	T4689	compound	Mtf1,knockout
R2948	T4689	T4682	compound	knockout,line
R2949	T4690	T4682	compound	mouse,line
R2950	T4692	T4693	advcl	Using,obtained
R2951	T4694	T4695	det	a,strategy
R2952	T4695	T4692	dobj	strategy,Using
R2953	T4696	T4695	amod	homologous,strategy
R2954	T4697	T4695	compound	recombination,strategy
R2955	T4698	T4693	punct	", ",obtained
R2956	T4699	T4693	nsubjpass	mice,obtained
R2957	T4700	T4693	auxpass	were,obtained
R2958	T4701	T4693	prep	with,obtained
R2959	T4702	T4703	det	a,Mtf1loxP
R2960	T4703	T4701	pobj	Mtf1loxP,with
R2961	T4704	T4703	amod	modified,Mtf1loxP
R2962	T4705	T4703	compound	Mtf1,Mtf1loxP
R2963	T4706	T4703	compound	allele,Mtf1loxP
R2964	T4707	T4708	advmod	where,flanked
R2965	T4708	T4693	advcl	flanked,obtained
R2966	T4709	T4710	nmod	exons,3
R2967	T4710	T4708	nsubjpass	3,flanked
R2968	T4711	T4710	cc	and,3
R2969	T4712	T4710	conj	4,3
R2970	T4713	T4710	punct	", ",3
R2971	T4714	T4710	acl	encoding,3
R2972	T4715	T4714	dobj	four,encoding
R2973	T4716	T4715	prep	of,four
R2974	T4717	T4718	det	the,fingers
R2975	T4718	T4716	pobj	fingers,of
R2976	T4719	T4718	nummod	six,fingers
R2977	T4720	T4718	compound	zinc,fingers
R2978	T4721	T4718	prep	of,fingers
R2979	T4722	T4723	det	the,domain
R2980	T4723	T4721	pobj	domain,of
R2981	T4724	T4725	npadvmod	DNA,binding
R2982	T4725	T4723	amod	binding,domain
R2983	T4726	T4725	punct	-,binding
R2984	T4727	T4708	punct	", ",flanked
R2985	T4728	T4708	auxpass	are,flanked
R2986	T4729	T4708	agent	by,flanked
R2987	T4730	T4731	compound	loxP,sites
R2988	T4731	T4729	pobj	sites,by
R2989	T4732	T4733	punct	(,1a
R2990	T4733	T4708	parataxis	1a,flanked
R2991	T4734	T4733	compound	Figure,1a
R2992	T4735	T4733	punct	),1a
R2993	T4736	T4693	punct	.,obtained
R2994	T4738	T4739	nsubjpass	Mice,crossed
R2995	T4740	T4738	amod	homozygous,Mice
R2996	T4741	T4740	prep	for,homozygous
R2997	T4742	T4743	det	the,allele
R2998	T4743	T4741	pobj	allele,for
R2999	T4744	T4743	compound	Mtf1loxP,allele
R3000	T4745	T4739	auxpass	were,crossed
R3001	T4746	T4739	advmod	further,crossed
R3002	T4747	T4739	prep	with,crossed
R3003	T4748	T4747	pobj	animals,with
R3004	T4749	T4748	prep	of,animals
R3005	T4750	T4751	det	the,line
R3006	T4751	T4749	pobj	line,of
R3007	T4752	T4753	nmod	Cre,recombinase
R3008	T4753	T4751	nmod	recombinase,line
R3009	T4754	T4751	amod	transgenic,line
R3010	T4755	T4756	compound	Mx,cre
R3011	T4756	T4751	appos	cre,line
R3012	T4757	T4756	punct	-,cre
R3013	T4758	T4739	punct	.,crossed
R3014	T4760	T4761	compound	Cre,recombinase
R3015	T4761	T4762	nsubjpass	recombinase,expressed
R3016	T4763	T4762	auxpass	is,expressed
R3017	T4764	T4762	prep	in,expressed
R3018	T4765	T4766	det	this,line
R3019	T4766	T4764	pobj	line,in
R3020	T4767	T4762	prep	under,expressed
R3021	T4768	T4769	det	the,control
R3022	T4769	T4767	pobj	control,under
R3023	T4770	T4769	prep	of,control
R3024	T4771	T4772	det	the,promoter
R3025	T4772	T4770	pobj	promoter,of
R3026	T4773	T4772	compound	mouse,promoter
R3027	T4774	T4772	compound	Mx1,promoter
R3028	T4775	T4772	compound	gene,promoter
R3029	T4776	T4772	punct	", ",promoter
R3030	T4777	T4778	dep	which,is
R3031	T4778	T4772	relcl	is,promoter
R3032	T4779	T4778	acomp	inducible,is
R3033	T4780	T4779	prep	by,inducible
R3034	T4781	T4780	pobj	administration,by
R3035	T4782	T4781	prep	of,administration
R3036	T4783	T4784	compound	interferon,alpha
R3037	T4784	T4782	pobj	alpha,of
R3038	T4785	T4784	cc	or,alpha
R3039	T4786	T4784	conj	beta,alpha
R3040	T4787	T4784	punct	", ",alpha
R3041	T4788	T4784	cc	or,alpha
R3042	T4789	T4790	amod	synthetic,pC
R3043	T4790	T4784	conj	pC,alpha
R3044	T4791	T4792	amod	double,stranded
R3045	T4792	T4790	amod	stranded,pC
R3046	T4793	T4792	punct	-,stranded
R3047	T4794	T4790	compound	RNA,pC
R3048	T4795	T4790	compound	pI,pC
R3049	T4796	T4790	punct	–,pC
R3050	T4797	T4798	punct	(,32
R3051	T4798	T4778	parataxis	32,is
R3052	T4799	T4798	punct	),32
R3053	T4800	T4762	punct	.,expressed
R3054	T4802	T4803	npadvmod	Cre,mediated
R3055	T4803	T4805	amod	mediated,deletion
R3056	T4804	T4803	punct	-,mediated
R3057	T4805	T4806	nsubjpass	deletion,reported
R3058	T4807	T4806	auxpass	was,reported
R3059	T4808	T4809	aux	to,be
R3060	T4809	T4806	xcomp	be,reported
R3061	T4810	T4809	acomp	complete,be
R3062	T4811	T4809	prep	in,be
R3063	T4812	T4813	det	the,liver
R3064	T4813	T4811	pobj	liver,in
R3065	T4814	T4809	punct	", ",be
R3066	T4815	T4816	mark	while,varying
R3067	T4816	T4809	advcl	varying,be
R3068	T4817	T4816	prep	in,varying
R3069	T4818	T4819	amod	other,tissues
R3070	T4819	T4817	pobj	tissues,in
R3071	T4820	T4816	punct	", ",varying
R3072	T4821	T4816	advcl	ranging,varying
R3073	T4822	T4821	prep	from,ranging
R3074	T4823	T4824	nummod	94,%
R3075	T4824	T4822	pobj	%,from
R3076	T4825	T4824	prep	in,%
R3077	T4826	T4825	pobj	spleen,in
R3078	T4827	T4822	prep	to,from
R3079	T4828	T4829	nummod	8,%
R3080	T4829	T4827	pobj	%,to
R3081	T4830	T4829	prep	in,%
R3082	T4831	T4830	pobj	brain,in
R3083	T4832	T4833	punct	(,32
R3084	T4833	T4816	parataxis	32,varying
R3085	T4834	T4833	punct	),32
R3086	T4835	T4806	punct	.,reported
R3087	T4837	T4838	prep	After,produced
R3088	T4839	T4840	npadvmod	Cre,mediated
R3089	T4840	T4842	amod	mediated,deletion
R3090	T4841	T4840	punct	-,mediated
R3091	T4842	T4837	pobj	deletion,After
R3092	T4843	T4842	prep	of,deletion
R3093	T4844	T4845	nmod	exons,3
R3094	T4845	T4843	pobj	3,of
R3095	T4846	T4845	cc	and,3
R3096	T4847	T4845	conj	4,3
R3097	T4848	T4842	punct	", ",deletion
R3098	T4849	T4850	dep	which,results
R3099	T4850	T4842	relcl	results,deletion
R3100	T4851	T4850	prep	in,results
R3101	T4852	T4853	det	a,stop
R3102	T4853	T4851	pobj	stop,in
R3103	T4854	T4853	nmod	frameshift,stop
R3104	T4855	T4854	cc	and,frameshift
R3105	T4856	T4857	amod	premature,translation
R3106	T4857	T4854	conj	translation,frameshift
R3107	T4858	T4838	punct	", ",produced
R3108	T4859	T4860	det	no,protein
R3109	T4860	T4838	nsubjpass	protein,produced
R3110	T4861	T4860	amod	functional,protein
R3111	T4862	T4860	nmod	MTF,protein
R3112	T4863	T4862	punct	-,MTF
R3113	T4864	T4862	nummod	1,MTF
R3114	T4865	T4838	aux	can,produced
R3115	T4866	T4838	auxpass	be,produced
R3116	T4867	T4838	punct	.,produced
R3117	T4869	T4870	prep	For,received
R3118	T4870	T4891	ccomp	received,received
R3119	T4871	T4869	pobj	induction,For
R3120	T4872	T4871	prep	of,induction
R3121	T4873	T4874	compound	Cre,recombinase
R3122	T4874	T4872	pobj	recombinase,of
R3123	T4875	T4870	punct	", ",received
R3124	T4876	T4877	nmod	Mtf1,mice
R3125	T4877	T4870	nsubj	mice,received
R3126	T4878	T4879	amod	conditional,knockout
R3127	T4879	T4877	compound	knockout,mice
R3128	T4880	T4877	acl	harboring,mice
R3129	T4881	T4882	det	the,transgene
R3130	T4882	T4880	dobj	transgene,harboring
R3131	T4883	T4884	compound	Mx,cre
R3132	T4884	T4882	compound	cre,transgene
R3133	T4885	T4884	punct	-,cre
R3134	T4886	T4882	punct	(,transgene
R3135	T4887	T4888	compound	Mtf1Mx,cre
R3136	T4888	T4882	appos	cre,transgene
R3137	T4889	T4888	punct	-,cre
R3138	T4890	T4870	punct	),received
R3139	T4892	T4893	nummod	four,injections
R3140	T4893	T4870	dobj	injections,received
R3141	T4894	T4893	amod	intraperitoneal,injections
R3142	T4895	T4896	compound	pI,pC
R3143	T4896	T4893	compound	pC,injections
R3144	T4897	T4896	punct	–,pC
R3145	T4898	T4870	prep	at,received
R3146	T4899	T4900	nummod	3,day
R3147	T4900	T4901	compound	day,intervals
R3148	T4901	T4898	pobj	intervals,at
R3149	T4902	T4903	punct	(,induction
R3150	T4903	T4870	parataxis	induction,received
R3151	T4904	T4905	compound	pI,pC
R3152	T4905	T4903	compound	pC,induction
R3153	T4906	T4905	punct	–,pC
R3154	T4907	T4903	punct	),induction
R3155	T4908	T4891	punct	;,received
R3156	T4909	T4910	compound	control,littermates
R3157	T4910	T4891	nsubj	littermates,received
R3158	T4911	T4910	prep	without,littermates
R3159	T4912	T4911	pobj	transgene,without
R3160	T4913	T4912	punct	(,transgene
R3161	T4914	T4912	appos	Mtf1loxP,transgene
R3162	T4915	T4891	punct	),received
R3163	T4916	T4917	amod	similar,injections
R3164	T4917	T4891	dobj	injections,received
R3165	T4918	T4891	punct	.,received
R3166	T4920	T4921	advcl	Using,obtained
R3167	T4922	T4923	compound	RT,PCRs
R3168	T4923	T4920	dobj	PCRs,Using
R3169	T4924	T4923	punct	–,PCRs
R3170	T4925	T4926	punct	(,1b
R3171	T4926	T4920	parataxis	1b,Using
R3172	T4927	T4926	compound	Figure,1b
R3173	T4928	T4926	punct	),1b
R3174	T4929	T4921	punct	", ",obtained
R3175	T4930	T4931	det	a,product
R3176	T4931	T4921	nsubjpass	product,obtained
R3177	T4932	T4931	amod	shortened,product
R3178	T4933	T4921	auxpass	was,obtained
R3179	T4934	T4921	prep	with,obtained
R3180	T4935	T4934	pobj	RNA,with
R3181	T4936	T4935	prep	from,RNA
R3182	T4937	T4938	compound	Mtf1Mx,cre
R3183	T4938	T4940	compound	cre,livers
R3184	T4939	T4938	punct	-,cre
R3185	T4940	T4936	pobj	livers,from
R3186	T4941	T4921	punct	", ",obtained
R3187	T4942	T4921	advcl	indicating,obtained
R3188	T4943	T4944	det	a,excision
R3189	T4944	T4942	dobj	excision,indicating
R3190	T4945	T4944	amod	successful,excision
R3191	T4946	T4944	prep	of,excision
R3192	T4947	T4948	nmod	exons,3
R3193	T4948	T4946	pobj	3,of
R3194	T4949	T4948	cc	and,3
R3195	T4950	T4948	conj	4,3
R3196	T4951	T4948	prep	of,3
R3197	T4952	T4951	pobj	Mtf1,of
R3198	T4953	T4942	prep	in,indicating
R3199	T4954	T4955	det	these,animals
R3200	T4955	T4953	pobj	animals,in
R3201	T4956	T4921	punct	.,obtained
R3202	T4958	T4959	prep	On,observed
R3203	T4960	T4961	amod	close,examination
R3204	T4961	T4958	pobj	examination,On
R3205	T4962	T4959	punct	", ",observed
R3206	T4963	T4964	det	a,band
R3207	T4964	T4959	nsubjpass	band,observed
R3208	T4965	T4966	advmod	very,faint
R3209	T4966	T4964	amod	faint,band
R3210	T4967	T4964	relcl	similar,band
R3211	T4968	T4967	prep	in,similar
R3212	T4969	T4968	pobj	size,in
R3213	T4970	T4967	prep	to,similar
R3214	T4971	T4972	amod	full,length
R3215	T4972	T4974	compound	length,signal
R3216	T4973	T4972	punct	-,length
R3217	T4974	T4970	pobj	signal,to
R3218	T4975	T4959	auxpass	was,observed
R3219	T4976	T4959	advmod	also,observed
R3220	T4977	T4959	prep	in,observed
R3221	T4978	T4979	det	those,mice
R3222	T4979	T4977	pobj	mice,in
R3223	T4980	T4959	punct	", ",observed
R3224	T4981	T4982	advmod	probably,due
R3225	T4982	T4959	prep	due,observed
R3226	T4983	T4982	pcomp	to,due
R3227	T4984	T4985	det	a,amount
R3228	T4985	T4982	pobj	amount,due
R3229	T4986	T4985	amod	low,amount
R3230	T4987	T4985	prep	of,amount
R3231	T4988	T4989	amod	residual,mRNA
R3232	T4989	T4987	pobj	mRNA,of
R3233	T4990	T4991	amod	full,length
R3234	T4991	T4989	compound	length,mRNA
R3235	T4992	T4991	punct	-,length
R3236	T4993	T4989	compound	Mtf1,mRNA
R3237	T4994	T4959	punct	.,observed
R3238	T4996	T4997	det	The,level
R3239	T4997	T4998	nsubjpass	level,examined
R3240	T4998	T5006	ccomp	examined,was
R3241	T4999	T4997	prep	of,level
R3242	T5000	T5001	amod	functional,protein
R3243	T5001	T4999	pobj	protein,of
R3244	T5002	T5001	nmod	MTF,protein
R3245	T5003	T5002	punct	-,MTF
R3246	T5004	T5002	nummod	1,MTF
R3247	T5005	T4998	auxpass	was,examined
R3248	T5007	T4998	prep	by,examined
R3249	T5008	T5007	pobj	EMSA,by
R3250	T5009	T5010	punct	(,1c
R3251	T5010	T4998	parataxis	1c,examined
R3252	T5011	T5010	compound	Figure,1c
R3253	T5012	T5010	punct	),1c
R3254	T5013	T5006	punct	: ,was
R3255	T5014	T5015	nmod	MTF,complex
R3256	T5015	T5006	nsubj	complex,was
R3257	T5016	T5014	punct	-,MTF
R3258	T5017	T5014	nummod	1,MTF
R3259	T5018	T5015	compound	protein,complex
R3260	T5019	T5015	punct	–,complex
R3261	T5020	T5015	compound	DNA,complex
R3262	T5021	T5006	acomp	detectable,was
R3263	T5022	T5021	prep	with,detectable
R3264	T5023	T5024	compound	liver,extract
R3265	T5024	T5022	pobj	extract,with
R3266	T5025	T5024	compound	protein,extract
R3267	T5026	T5024	prep	from,extract
R3268	T5027	T5028	det	an,mouse
R3269	T5028	T5026	pobj	mouse,from
R3270	T5029	T5028	compound	Mtf1loxP,mouse
R3271	T5030	T5028	compound	control,mouse
R3272	T5031	T5006	punct	", ",was
R3273	T5032	T5006	cc	but,was
R3274	T5033	T5034	det	no,protein
R3275	T5034	T5039	nsubjpass	protein,observed
R3276	T5035	T5034	amod	functional,protein
R3277	T5036	T5037	npadvmod	MRE,binding
R3278	T5037	T5034	amod	binding,protein
R3279	T5038	T5037	punct	-,binding
R3280	T5039	T5006	conj	observed,was
R3281	T5040	T5039	auxpass	was,observed
R3282	T5041	T5039	prep	with,observed
R3283	T5042	T5043	det	an,sample
R3284	T5043	T5041	pobj	sample,with
R3285	T5044	T5045	compound	Mtf1Mx,cre
R3286	T5045	T5043	compound	cre,sample
R3287	T5046	T5045	punct	-,cre
R3288	T5047	T5006	punct	.,was
R3289	T5049	T5050	advmod	Thus,was
R3290	T5051	T5050	punct	", ",was
R3291	T5052	T5050	nsubj	deletion,was
R3292	T5053	T5052	prep	of,deletion
R3293	T5054	T5055	nmod	exons,3
R3294	T5055	T5053	pobj	3,of
R3295	T5056	T5055	cc	and,3
R3296	T5057	T5055	conj	4,3
R3297	T5058	T5055	prep	of,3
R3298	T5059	T5058	pobj	Mtf1,of
R3299	T5060	T5052	prep	in,deletion
R3300	T5061	T5062	det	the,liver
R3301	T5062	T5060	pobj	liver,in
R3302	T5063	T5062	prep	of,liver
R3303	T5064	T5065	compound	Mtf1Mx,cre
R3304	T5065	T5067	compound	cre,mice
R3305	T5066	T5065	punct	-,cre
R3306	T5067	T5063	pobj	mice,of
R3307	T5068	T5069	advmod	virtually,complete
R3308	T5069	T5050	acomp	complete,was
R3309	T5070	T5050	punct	.,was
R3310	T5072	T5073	det	All,mice
R3311	T5073	T5079	nsubj	mice,were
R3312	T5074	T5073	amod	examined,mice
R3313	T5075	T5076	npadvmod	liver,specific
R3314	T5076	T5073	amod	specific,mice
R3315	T5077	T5076	punct	-,specific
R3316	T5078	T5073	compound	knockout,mice
R3317	T5080	T5079	acomp	viable,were
R3318	T5081	T5079	prep	under,were
R3319	T5082	T5083	compound	laboratory,conditions
R3320	T5083	T5081	pobj	conditions,under
R3321	T5084	T5079	cc	and,were
R3322	T5085	T5079	conj	appeared,were
R3323	T5086	T5085	oprd	normal,appeared
R3324	T5087	T5079	punct	.,were
R3325	T5337	T5338	nmod	MTF,search
R3326	T5339	T5337	punct	-,MTF
R3327	T5340	T5337	nummod	1,MTF
R3328	T5341	T5338	compound	target,search
R3329	T5342	T5338	compound	gene,search
R3330	T5344	T5345	prep	For,compared
R3331	T5346	T5347	det	the,identification
R3332	T5347	T5344	pobj	identification,For
R3333	T5348	T5347	prep	of,identification
R3334	T5349	T5350	nmod	MTF,genes
R3335	T5350	T5348	pobj	genes,of
R3336	T5351	T5349	punct	-,MTF
R3337	T5352	T5349	nummod	1,MTF
R3338	T5353	T5350	compound	target,genes
R3339	T5354	T5345	punct	", ",compared
R3340	T5355	T5345	nsubj	we,compared
R3341	T5356	T5357	det	the,profiles
R3342	T5357	T5345	dobj	profiles,compared
R3343	T5358	T5357	compound	liver,profiles
R3344	T5359	T5357	compound	transcript,profiles
R3345	T5360	T5357	prep	of,profiles
R3346	T5361	T5360	pobj	mice,of
R3347	T5362	T5361	prep	with,mice
R3348	T5363	T5362	cc	and,with
R3349	T5364	T5362	conj	without,with
R3350	T5365	T5366	amod	functional,gene
R3351	T5366	T5364	pobj	gene,without
R3352	T5367	T5366	compound	Mtf1,gene
R3353	T5368	T5369	dep	that,treated
R3354	T5369	T5366	relcl	treated,gene
R3355	T5370	T5369	aux	had,treated
R3356	T5371	T5369	auxpass	been,treated
R3357	T5372	T5369	amod	mock,treated
R3358	T5373	T5369	punct	-,treated
R3359	T5374	T5369	cc	or,treated
R3360	T5375	T5369	conj	exposed,treated
R3361	T5376	T5375	prep	to,exposed
R3362	T5377	T5376	pobj	cadmium,to
R3363	T5378	T5379	punct	(,3
R3364	T5379	T5375	parataxis	3,exposed
R3365	T5380	T5379	nsubj	n,3
R3366	T5381	T5379	punct	=,3
R3367	T5382	T5379	prep	per,3
R3368	T5383	T5382	pobj	genotype,per
R3369	T5384	T5379	cc	and,3
R3370	T5385	T5386	amod	respective,treatment
R3371	T5386	T5379	conj	treatment,3
R3372	T5387	T5379	punct	),3
R3373	T5388	T5345	punct	.,compared
R3374	T5390	T5391	prep	In,analyzed
R3375	T5392	T5393	det	a,screen
R3376	T5393	T5390	pobj	screen,In
R3377	T5394	T5393	amod	first,screen
R3378	T5395	T5391	punct	", ",analyzed
R3379	T5396	T5397	det	the,transcripts
R3380	T5397	T5391	nsubjpass	transcripts,analyzed
R3381	T5398	T5391	auxpass	were,analyzed
R3382	T5399	T5391	prep	with,analyzed
R3383	T5400	T5401	det	a,method
R3384	T5401	T5399	pobj	method,with
R3385	T5402	T5401	amod	differential,method
R3386	T5403	T5404	npadvmod	display,based
R3387	T5404	T5401	amod	based,method
R3388	T5405	T5404	punct	-,based
R3389	T5406	T5391	punct	", ",analyzed
R3390	T5407	T5391	dep	called,analyzed
R3391	T5408	T5407	oprd	amplification,called
R3392	T5409	T5408	prep	of,amplification
R3393	T5410	T5411	amod	double,stranded
R3394	T5411	T5413	amod	stranded,fragments
R3395	T5412	T5411	punct	-,stranded
R3396	T5413	T5409	pobj	fragments,of
R3397	T5414	T5413	compound	cDNA,fragments
R3398	T5415	T5413	compound	end,fragments
R3399	T5416	T5413	compound	restriction,fragments
R3400	T5417	T5408	punct	(,amplification
R3401	T5418	T5408	appos	ADDER,amplification
R3402	T5419	T5407	punct	),called
R3403	T5420	T5421	punct	(,33
R3404	T5421	T5407	parataxis	33,called
R3405	T5422	T5421	punct	),33
R3406	T5423	T5391	punct	.,analyzed
R3407	T5425	T5426	advmod	Thereby,obtained
R3408	T5427	T5428	det	an,number
R3409	T5428	T5426	nsubjpass	number,obtained
R3410	T5429	T5428	amod	overwhelming,number
R3411	T5430	T5428	prep	of,number
R3412	T5431	T5430	pobj	signals,of
R3413	T5432	T5426	auxpass	was,obtained
R3414	T5433	T5426	prep	for,obtained
R3415	T5434	T5435	det	the,metallothioneins
R3416	T5435	T5433	pobj	metallothioneins,for
R3417	T5436	T5435	nummod	two,metallothioneins
R3418	T5437	T5438	npadvmod	stress,inducible
R3419	T5438	T5435	amod	inducible,metallothioneins
R3420	T5439	T5438	punct	-,inducible
R3421	T5440	T5435	punct	(,metallothioneins
R3422	T5441	T5435	appos	Mt1,metallothioneins
R3423	T5442	T5441	cc	and,Mt1
R3424	T5443	T5441	conj	Mt2,Mt1
R3425	T5444	T5426	punct	),obtained
R3426	T5445	T5426	punct	", ",obtained
R3427	T5446	T5426	prep	due,obtained
R3428	T5447	T5446	pcomp	to,due
R3429	T5448	T5449	det	the,abundance
R3430	T5449	T5446	pobj	abundance,due
R3431	T5450	T5449	prep	of,abundance
R3432	T5451	T5452	poss	their,transcripts
R3433	T5452	T5450	pobj	transcripts,of
R3434	T5453	T5454	preconj	both,in
R3435	T5454	T5449	prep	in,abundance
R3436	T5455	T5456	amod	mock,treated
R3437	T5456	T5454	pobj	treated,in
R3438	T5457	T5456	punct	-,treated
R3439	T5458	T5454	cc	and,in
R3440	T5459	T5460	advmod	especially,in
R3441	T5460	T5454	conj	in,in
R3442	T5461	T5462	npadvmod	cadmium,treated
R3443	T5462	T5460	pobj	treated,in
R3444	T5463	T5462	punct	-,treated
R3445	T5464	T5460	pobj	livers,in
R3446	T5465	T5466	dep	that,harbored
R3447	T5466	T5460	pcomp	harbored,in
R3448	T5467	T5468	det	a,gene
R3449	T5468	T5466	dobj	gene,harbored
R3450	T5469	T5468	amod	functional,gene
R3451	T5470	T5468	nmod	MTF,gene
R3452	T5471	T5470	punct	-,MTF
R3453	T5472	T5470	nummod	1,MTF
R3454	T5473	T5474	punct	(,shown
R3455	T5474	T5426	parataxis	shown,obtained
R3456	T5475	T5474	nsubj	data,shown
R3457	T5476	T5474	neg	not,shown
R3458	T5477	T5474	punct	),shown
R3459	T5478	T5426	punct	.,obtained
R3460	T5480	T5481	det	This,result
R3461	T5481	T5482	nsubj	result,confirmed
R3462	T5483	T5484	det	the,importance
R3463	T5484	T5482	dobj	importance,confirmed
R3464	T5485	T5484	prep	of,importance
R3465	T5486	T5485	pobj	MTF,of
R3466	T5487	T5486	punct	-,MTF
R3467	T5488	T5486	nummod	1,MTF
R3468	T5489	T5484	prep	for,importance
R3469	T5490	T5491	preconj	both,basal
R3470	T5491	T5492	amod	basal,expression
R3471	T5492	T5489	pobj	expression,for
R3472	T5493	T5491	cc	and,basal
R3473	T5494	T5495	npadvmod	metal,induced
R3474	T5495	T5491	conj	induced,basal
R3475	T5496	T5495	punct	-,induced
R3476	T5497	T5492	prep	of,expression
R3477	T5498	T5499	compound	metallothionein,genes
R3478	T5499	T5497	pobj	genes,of
R3479	T5500	T5482	punct	.,confirmed
R3480	T5502	T5503	prep	In,compared
R3481	T5504	T5505	det	a,approach
R3482	T5505	T5502	pobj	approach,In
R3483	T5506	T5505	amod	second,approach
R3484	T5507	T5503	punct	", ",compared
R3485	T5508	T5509	det	the,profile
R3486	T5509	T5503	nsubjpass	profile,compared
R3487	T5510	T5511	compound	gene,expression
R3488	T5511	T5509	compound	expression,profile
R3489	T5512	T5509	prep	in,profile
R3490	T5513	T5512	pobj	livers,in
R3491	T5514	T5513	prep	of,livers
R3492	T5515	T5516	det	the,mice
R3493	T5516	T5514	pobj	mice,of
R3494	T5517	T5518	advmod	above,mentioned
R3495	T5518	T5516	amod	mentioned,mice
R3496	T5519	T5503	auxpass	was,compared
R3497	T5520	T5503	agent	by,compared
R3498	T5521	T5522	nmod	Affymetrix,GeneChip
R3499	T5522	T5523	nmod	GeneChip,Arrays
R3500	T5523	T5520	pobj	Arrays,by
R3501	T5524	T5522	punct	®,GeneChip
R3502	T5525	T5526	nmod	Mouse,Genome
R3503	T5526	T5523	nmod	Genome,Arrays
R3504	T5527	T5526	nummod	430,Genome
R3505	T5528	T5526	nummod	2.0,Genome
R3506	T5529	T5530	punct	(,Table
R3507	T5530	T5503	parataxis	Table,compared
R3508	T5531	T5530	nummod	1,Table
R3509	T5532	T5530	punct	),Table
R3510	T5533	T5503	punct	.,compared
R3511	T5535	T5536	advmod	When,analyzing
R3512	T5536	T5537	advcl	analyzing,detected
R3513	T5538	T5539	det	the,data
R3514	T5539	T5536	dobj	data,analyzing
R3515	T5540	T5539	compound	probe,data
R3516	T5541	T5539	compound	array,data
R3517	T5542	T5539	prep	of,data
R3518	T5543	T5542	pobj	livers,of
R3519	T5544	T5543	prep	from,livers
R3520	T5545	T5546	amod	mock,treated
R3521	T5546	T5548	amod	treated,mice
R3522	T5547	T5546	punct	-,treated
R3523	T5548	T5544	pobj	mice,from
R3524	T5549	T5550	nmod	Mtf1Mx,cre
R3525	T5550	T5548	nmod	cre,mice
R3526	T5551	T5550	punct	-,cre
R3527	T5552	T5550	cc	and,cre
R3528	T5553	T5550	conj	Mtf1loxP,cre
R3529	T5554	T5537	punct	", ",detected
R3530	T5555	T5556	det	an,downregulation
R3531	T5556	T5537	nsubjpass	downregulation,detected
R3532	T5557	T5558	advmod	at,least
R3533	T5558	T5559	advmod	least,2-fold
R3534	T5559	T5556	nummod	2-fold,downregulation
R3535	T5560	T5556	punct	", ",downregulation
R3536	T5561	T5556	amod	reliable,downregulation
R3537	T5562	T5556	prep	of,downregulation
R3538	T5563	T5562	pobj	expression,of
R3539	T5564	T5537	auxpass	was,detected
R3540	T5565	T5537	prep	in,detected
R3541	T5566	T5567	compound	Mtf1Mx,cre
R3542	T5567	T5569	compound	cre,livers
R3543	T5568	T5567	punct	-,cre
R3544	T5569	T5565	pobj	livers,in
R3545	T5570	T5537	prep	for,detected
R3546	T5571	T5572	nummod	13,sets
R3547	T5572	T5570	pobj	sets,for
R3548	T5573	T5574	nmod	Affymetrix,GeneChip
R3549	T5574	T5572	nmod	GeneChip,sets
R3550	T5575	T5574	punct	®,GeneChip
R3551	T5576	T5572	compound	probe,sets
R3552	T5577	T5572	acl	corresponding,sets
R3553	T5578	T5577	prep	to,corresponding
R3554	T5579	T5580	nummod	11,genes
R3555	T5580	T5578	pobj	genes,to
R3556	T5581	T5580	amod	characterized,genes
R3557	T5582	T5583	punct	(,a
R3558	T5583	T5537	parataxis	a,detected
R3559	T5584	T5583	nmod	Table,a
R3560	T5585	T5583	nummod	1,a
R3561	T5586	T5583	punct	", ",a
R3562	T5587	T5583	punct	),a
R3563	T5588	T5537	punct	.,detected
R3564	T5590	T5591	nsubj	Seven,contain
R3565	T5592	T5590	prep	of,Seven
R3566	T5593	T5594	det	these,genes
R3567	T5594	T5592	pobj	genes,of
R3568	T5595	T5596	nummod	one,TGCRCNC
R3569	T5596	T5591	dobj	TGCRCNC,contain
R3570	T5597	T5595	cc	or,one
R3571	T5598	T5595	conj	more,one
R3572	T5599	T5600	compound	MRE,core
R3573	T5600	T5596	compound	core,TGCRCNC
R3574	T5601	T5596	compound	consensus,TGCRCNC
R3575	T5602	T5596	compound	sequence,TGCRCNC
R3576	T5603	T5596	prep	within,TGCRCNC
R3577	T5604	T5605	det	a,segment
R3578	T5605	T5603	pobj	segment,within
R3579	T5606	T5605	prep	of,segment
R3580	T5607	T5608	nummod	1000,bp
R3581	T5608	T5606	pobj	bp,of
R3582	T5609	T5605	advmod	upstream,segment
R3583	T5610	T5609	prep	of,upstream
R3584	T5611	T5612	det	the,start
R3585	T5612	T5610	pobj	start,of
R3586	T5613	T5612	compound	transcription,start
R3587	T5614	T5591	punct	.,contain
R3588	T5616	T5617	prep	For,detected
R3589	T5617	T5636	ccomp	detected,contain
R3590	T5618	T5619	nummod	26,sets
R3591	T5619	T5616	pobj	sets,For
R3592	T5620	T5619	compound	probe,sets
R3593	T5621	T5619	acl	corresponding,sets
R3594	T5622	T5621	prep	to,corresponding
R3595	T5623	T5624	nummod	24,genes
R3596	T5624	T5622	pobj	genes,to
R3597	T5625	T5624	amod	different,genes
R3598	T5626	T5624	amod	characterized,genes
R3599	T5627	T5617	punct	", ",detected
R3600	T5628	T5629	det	a,upregulation
R3601	T5629	T5617	nsubjpass	upregulation,detected
R3602	T5630	T5629	amod	2-fold,upregulation
R3603	T5631	T5630	cc	or,2-fold
R3604	T5632	T5630	conj	higher,2-fold
R3605	T5633	T5629	punct	", ",upregulation
R3606	T5634	T5629	amod	reliable,upregulation
R3607	T5635	T5617	auxpass	was,detected
R3608	T5637	T5617	prep	in,detected
R3609	T5638	T5639	compound	Mtf1Mx,cre
R3610	T5639	T5641	compound	cre,livers
R3611	T5640	T5639	punct	-,cre
R3612	T5641	T5637	pobj	livers,in
R3613	T5642	T5643	punct	(,b
R3614	T5643	T5641	parataxis	b,livers
R3615	T5644	T5643	nmod	Table,b
R3616	T5645	T5643	nummod	1,b
R3617	T5646	T5643	punct	", ",b
R3618	T5647	T5643	punct	),b
R3619	T5648	T5636	punct	;,contain
R3620	T5649	T5636	nsubj	17,contain
R3621	T5650	T5649	prep	of,17
R3622	T5651	T5652	det	these,genes
R3623	T5652	T5650	pobj	genes,of
R3624	T5653	T5652	nummod	24,genes
R3625	T5654	T5655	compound	MRE,core
R3626	T5655	T5656	compound	core,sequences
R3627	T5656	T5636	dobj	sequences,contain
R3628	T5657	T5656	compound	consensus,sequences
R3629	T5658	T5636	prep	in,contain
R3630	T5659	T5660	det	the,region
R3631	T5660	T5658	pobj	region,in
R3632	T5661	T5660	amod	upstream,region
R3633	T5662	T5636	punct	.,contain
R3634	T5664	T5665	det	The,set
R3635	T5665	T5667	nsubj	set,revealed
R3636	T5666	T5665	compound	data,set
R3638	T5668	T5665	prep	for,set
R3639	T5669	T5668	pobj	livers,for
R3640	T5670	T5669	prep	of,livers
R3641	T5671	T5672	npadvmod	cadmium,treated
R3642	T5672	T5674	amod	treated,mice
R3643	T5673	T5672	punct	-,treated
R3644	T5674	T5670	pobj	mice,of
R3645	T5675	T5676	nmod	Mtf1Mx,cre
R3646	T5676	T5674	nmod	cre,mice
R3647	T5677	T5676	punct	-,cre
R3648	T5678	T5676	cc	and,cre
R3649	T5679	T5676	conj	Mtf1loxP,cre
R3650	T5681	T5682	det	an,downregulation
R3651	T5682	T5667	dobj	downregulation,revealed
R3652	T5683	T5684	advmod	at,least
R3653	T5684	T5685	advmod	least,2-fold
R3654	T5685	T5682	amod	2-fold,downregulation
R3655	T5686	T5682	punct	", ",downregulation
R3656	T5687	T5682	amod	reliable,downregulation
R3657	T5688	T5667	prep	in,revealed
R3658	T5689	T5690	compound	Mtf1Mx,cre
R3659	T5690	T5692	compound	cre,livers
R3660	T5691	T5690	punct	-,cre
R3661	T5692	T5688	pobj	livers,in
R3662	T5693	T5667	prep	for,revealed
R3663	T5694	T5695	nummod	21,sets
R3664	T5695	T5693	pobj	sets,for
R3665	T5696	T5695	compound	probe,sets
R3666	T5697	T5695	acl	corresponding,sets
R3667	T5698	T5697	prep	to,corresponding
R3668	T5699	T5700	nummod	16,genes
R3669	T5700	T5698	pobj	genes,to
R3670	T5701	T5700	amod	different,genes
R3671	T5702	T5700	amod	characterized,genes
R3672	T5703	T5704	punct	(,c
R3673	T5704	T5667	parataxis	c,revealed
R3674	T5705	T5704	nmod	Table,c
R3675	T5706	T5704	nummod	1,c
R3676	T5707	T5704	punct	", ",c
R3677	T5708	T5704	punct	),c
R3678	T5709	T5680	punct	;,contain
R3679	T5710	T5680	nsubj	10,contain
R3680	T5711	T5710	prep	of,10
R3681	T5712	T5711	pobj	these,of
R3682	T5713	T5714	compound	MRE,sequences
R3683	T5714	T5680	dobj	sequences,contain
R3684	T5715	T5714	compound	core,sequences
R3685	T5716	T5714	compound	consensus,sequences
R3686	T5717	T5680	prep	in,contain
R3687	T5718	T5719	poss	their,region
R3688	T5719	T5717	pobj	region,in
R3689	T5720	T5719	amod	upstream,region
R3690	T5721	T5680	punct	.,contain
R3691	T5723	T5724	prep	For,detected
R3692	T5724	T5743	ccomp	detected,contain
R3693	T5725	T5726	nummod	9,sets
R3694	T5726	T5723	pobj	sets,For
R3695	T5727	T5726	compound	probe,sets
R3696	T5728	T5726	acl	corresponding,sets
R3697	T5729	T5728	prep	to,corresponding
R3698	T5730	T5731	nummod	9,genes
R3699	T5731	T5729	pobj	genes,to
R3700	T5732	T5731	amod	different,genes
R3701	T5733	T5731	amod	characterized,genes
R3702	T5734	T5724	punct	", ",detected
R3703	T5735	T5736	det	an,upregulation
R3704	T5736	T5724	nsubjpass	upregulation,detected
R3705	T5737	T5738	advmod	at,least
R3706	T5738	T5739	advmod	least,2-fold
R3707	T5739	T5736	nummod	2-fold,upregulation
R3708	T5740	T5736	punct	", ",upregulation
R3709	T5741	T5736	amod	reliable,upregulation
R3710	T5742	T5724	auxpass	was,detected
R3711	T5744	T5745	punct	(,d
R3712	T5745	T5724	parataxis	d,detected
R3713	T5746	T5745	nmod	Table,d
R3714	T5747	T5745	nummod	1,d
R3715	T5748	T5745	punct	", ",d
R3716	T5749	T5745	punct	),d
R3717	T5750	T5743	punct	;,contain
R3718	T5751	T5743	nsubj	five,contain
R3719	T5752	T5751	prep	of,five
R3720	T5753	T5752	pobj	them,of
R3721	T5754	T5755	compound	MRE,motifs
R3722	T5755	T5743	dobj	motifs,contain
R3723	T5756	T5743	punct	.,contain
R3724	T5758	T5759	prep	In,found
R3725	T5760	T5758	pobj	addition,In
R3726	T5761	T5760	prep	to,addition
R3727	T5762	T5763	amod	characterized,genes
R3728	T5763	T5761	pobj	genes,to
R3729	T5764	T5759	punct	", ",found
R3730	T5765	T5759	nsubjpass	ESTs,found
R3731	T5766	T5765	cc	and,ESTs
R3732	T5767	T5768	compound	RIKEN,cDNA
R3733	T5768	T5769	compound	cDNA,sequences
R3734	T5769	T5765	conj	sequences,ESTs
R3735	T5770	T5759	auxpass	were,found
R3736	T5771	T5759	advmod	also,found
R3737	T5772	T5759	prep	in,found
R3738	T5773	T5774	det	the,comparison
R3739	T5774	T5772	pobj	comparison,in
R3740	T5775	T5774	prep	of,comparison
R3741	T5776	T5777	nmod	Mtf1Mx,cre
R3742	T5777	T5779	nmod	cre,livers
R3743	T5778	T5777	punct	-,cre
R3744	T5779	T5775	pobj	livers,of
R3745	T5780	T5777	cc	and,cre
R3746	T5781	T5777	conj	Mtf1loxP,cre
R3747	T5782	T5783	aux	to,expressed
R3748	T5783	T5759	xcomp	expressed,found
R3749	T5784	T5783	auxpass	be,expressed
R3750	T5785	T5783	advmod	differentially,expressed
R3751	T5786	T5787	punct	(,Table
R3752	T5787	T5759	parataxis	Table,found
R3753	T5788	T5787	amod	Supplementary,Table
R3754	T5789	T5787	nummod	1,Table
R3755	T5790	T5787	punct	),Table
R3756	T5791	T5759	punct	.,found
R3757	T5793	T5794	nsubjpass	Downregulation,detected
R3758	T5795	T5793	prep	of,Downregulation
R3759	T5796	T5795	pobj	Mt1,of
R3760	T5797	T5796	cc	and,Mt1
R3761	T5798	T5796	conj	Mt2,Mt1
R3762	T5799	T5794	auxpass	was,detected
R3763	T5800	T5794	prep	in,detected
R3764	T5801	T5802	compound	Mtf1Mx,cre
R3765	T5802	T5804	compound	cre,livers
R3766	T5803	T5802	punct	-,cre
R3767	T5804	T5800	pobj	livers,in
R3768	T5805	T5794	prep	for,detected
R3769	T5806	T5807	det	both,conditions
R3770	T5807	T5805	pobj	conditions,for
R3771	T5808	T5794	punct	(,detected
R3772	T5809	T5810	mark	though,was
R3773	T5810	T5794	advcl	was,detected
R3774	T5811	T5812	det	the,level
R3775	T5812	T5810	nsubj	level,was
R3776	T5813	T5812	prep	of,level
R3777	T5814	T5813	pobj	significance,of
R3778	T5815	T5812	prep	for,level
R3779	T5816	T5817	det	the,downregulation
R3780	T5817	T5815	pobj	downregulation,for
R3781	T5818	T5817	prep	of,downregulation
R3782	T5819	T5818	pobj	Mt1,of
R3783	T5820	T5812	prep	in,level
R3784	T5821	T5822	amod	mock,treated
R3785	T5822	T5824	amod	treated,animals
R3786	T5823	T5822	punct	-,treated
R3787	T5824	T5820	pobj	animals,in
R3788	T5825	T5826	quantmod	above,0.05
R3789	T5826	T5810	attr	0.05,was
R3790	T5827	T5810	punct	;,was
R3791	T5828	T5829	nsubj	data,shown
R3792	T5829	T5810	parataxis	shown,was
R3793	T5830	T5829	neg	not,shown
R3794	T5831	T5794	punct	),detected
R3795	T5832	T5794	punct	.,detected
R3796	T5834	T5835	prep	For,exerts
R3797	T5836	T5837	det	all,genes
R3798	T5837	T5834	pobj	genes,For
R3799	T5838	T5837	nmod	MTF,genes
R3800	T5839	T5838	punct	-,MTF
R3801	T5840	T5838	nummod	1,MTF
R3802	T5841	T5837	compound	target,genes
R3803	T5842	T5837	acl	characterized,genes
R3804	T5843	T5844	advmod	so,far
R3805	T5844	T5842	advmod	far,characterized
R3806	T5845	T5837	punct	", ",genes
R3807	T5846	T5847	amod	such,as
R3808	T5847	T5837	prep	as,genes
R3809	T5848	T5847	pobj	Mt1,as
R3810	T5849	T5848	punct	", ",Mt1
R3811	T5850	T5848	conj	Mt2,Mt1
R3812	T5851	T5850	cc	and,Mt2
R3813	T5852	T5850	conj	Znt1,Mt2
R3814	T5853	T5835	punct	", ",exerts
R3815	T5854	T5835	nsubj	MTF,exerts
R3816	T5855	T5854	punct	-,MTF
R3817	T5856	T5854	nummod	1,MTF
R3818	T5857	T5858	poss	its,activity
R3819	T5858	T5835	dobj	activity,exerts
R3820	T5859	T5860	amod	transcriptional,activation
R3821	T5860	T5858	compound	activation,activity
R3822	T5861	T5835	prep	via,exerts
R3823	T5862	T5863	amod	standard,sequences
R3824	T5863	T5861	pobj	sequences,via
R3825	T5864	T5863	compound	MRE,sequences
R3826	T5865	T5863	acl	located,sequences
R3827	T5866	T5865	advmod	proximal,located
R3828	T5867	T5866	prep	to,proximal
R3829	T5868	T5869	det	the,start
R3830	T5869	T5867	pobj	start,to
R3831	T5870	T5869	compound	transcription,start
R3832	T5871	T5872	punct	(,19
R3833	T5872	T5835	parataxis	19,exerts
R3834	T5873	T5872	nummod	4,19
R3835	T5874	T5872	punct	",",19
R3836	T5875	T5872	nummod	5,19
R3837	T5876	T5872	punct	",",19
R3838	T5877	T5872	nummod	8,19
R3839	T5878	T5872	punct	",",19
R3840	T5879	T5872	nummod	18,19
R3841	T5880	T5872	punct	",",19
R3842	T5881	T5872	punct	),19
R3843	T5882	T5835	punct	.,exerts
R3844	T5884	T5885	advmod	Even,search
R3845	T5885	T5888	nsubj	search,yielded
R3846	T5886	T5885	det	a,search
R3847	T5887	T5885	amod	specific,search
R3848	T5889	T5885	prep	for,search
R3849	T5890	T5891	nmod	MTF,sites
R3850	T5891	T5889	pobj	sites,for
R3851	T5892	T5890	punct	-,MTF
R3852	T5893	T5890	nummod	1,MTF
R3853	T5894	T5891	compound	binding,sites
R3854	T5895	T5885	prep	by,search
R3855	T5896	T5895	pobj	selection,by
R3856	T5897	T5896	prep	from,selection
R3857	T5898	T5899	det	a,pool
R3858	T5899	T5897	pobj	pool,from
R3859	T5900	T5899	prep	of,pool
R3860	T5901	T5902	amod	double,stranded
R3861	T5902	T5904	amod	stranded,oligonucleotides
R3862	T5903	T5902	punct	-,stranded
R3863	T5904	T5900	pobj	oligonucleotides,of
R3864	T5905	T5904	prep	with,oligonucleotides
R3865	T5906	T5907	amod	random,sequences
R3866	T5907	T5905	pobj	sequences,with
R3867	T5908	T5909	det	no,motif
R3868	T5909	T5888	dobj	motif,yielded
R3869	T5910	T5909	amod	new,motif
R3870	T5911	T5909	compound	binding,motif
R3871	T5912	T5909	prep	for,motif
R3872	T5913	T5912	pobj	MTF,for
R3873	T5914	T5913	punct	-,MTF
R3874	T5915	T5913	nummod	1,MTF
R3875	T5916	T5909	prep	in,motif
R3876	T5917	T5916	pobj	addition,in
R3877	T5918	T5917	prep	to,addition
R3878	T5919	T5920	det	the,MREs
R3879	T5920	T5918	pobj	MREs,to
R3880	T5921	T5920	amod	known,MREs
R3881	T5922	T5923	punct	(,34
R3882	T5923	T5888	parataxis	34,yielded
R3883	T5924	T5923	punct	),34
R3884	T5925	T5888	punct	.,yielded
R3885	T5927	T5928	advmod	Thus,is
R3886	T5929	T5928	punct	", ",is
R3887	T5930	T5931	det	an,sequence
R3888	T5931	T5928	nsubj	sequence,is
R3889	T5932	T5931	compound	MRE,sequence
R3890	T5933	T5928	prep	to,is
R3891	T5934	T5933	pobj	date,to
R3892	T5935	T5936	det	the,indication
R3893	T5936	T5928	attr	indication,is
R3894	T5937	T5936	amod	only,indication
R3895	T5938	T5936	prep	for,indication
R3896	T5939	T5940	det	a,gene
R3897	T5940	T5938	pobj	gene,for
R3898	T5941	T5940	amod	direct,gene
R3899	T5942	T5940	nmod	MTF,gene
R3900	T5943	T5942	punct	-,MTF
R3901	T5944	T5942	nummod	1,MTF
R3902	T5945	T5940	compound	target,gene
R3903	T5946	T5928	punct	", ",is
R3904	T5947	T5928	cc	and,is
R3905	T5948	T5949	nummod	four,candidates
R3906	T5949	T5955	nsubjpass	candidates,analyzed
R3907	T5950	T5951	npadvmod	MRE,containing
R3908	T5951	T5949	amod	containing,candidates
R3909	T5952	T5951	punct	-,containing
R3910	T5953	T5949	compound	target,candidates
R3911	T5954	T5949	compound	gene,candidates
R3912	T5955	T5928	conj	analyzed,is
R3913	T5956	T5955	auxpass	were,analyzed
R3914	T5957	T5955	advmod	further,analyzed
R3915	T5958	T5955	punct	.,analyzed
R3916	T6000	T6001	amod	Basal,expression
R3917	T6001	T6002	nsubj	expression,depends
R3918	T6003	T6001	prep	of,expression
R3919	T6004	T6003	pobj	Sepw1,of
R3920	T6005	T6002	prep	on,depends
R3921	T6006	T6005	pobj	MTF,on
R3922	T6007	T6006	punct	-,MTF
R3923	T6008	T6006	nummod	1,MTF
R3924	T6010	T6011	nsubjpass	Sepw1,found
R3925	T6012	T6011	auxpass	was,found
R3926	T6013	T6011	prep	in,found
R3927	T6014	T6015	compound	microarray,analysis
R3928	T6015	T6013	pobj	analysis,in
R3929	T6016	T6017	aux	to,be
R3930	T6017	T6011	xcomp	be,found
R3931	T6018	T6017	advmod	significantly,be
R3932	T6019	T6017	acomp	downregulated,be
R3933	T6020	T6017	prep	in,be
R3934	T6021	T6020	pobj	livers,in
R3935	T6022	T6021	prep	from,livers
R3936	T6023	T6024	npadvmod	cadmium,treated
R3937	T6024	T6029	amod	treated,mice
R3938	T6025	T6023	punct	-,cadmium
R3939	T6026	T6023	cc	and,cadmium
R3940	T6027	T6023	conj	mock,cadmium
R3941	T6028	T6024	punct	-,treated
R3942	T6029	T6022	pobj	mice,from
R3943	T6030	T6031	compound	Mtf1Mx,cre
R3944	T6031	T6029	compound	cre,mice
R3945	T6032	T6031	punct	-,cre
R3946	T6033	T6034	punct	(,a
R3947	T6034	T6011	parataxis	a,found
R3948	T6035	T6034	dep	Table,a
R3949	T6036	T6035	nummod	1,Table
R3950	T6037	T6034	punct	", ",a
R3951	T6038	T6034	cc	and,a
R3952	T6039	T6034	conj	c,a
R3953	T6040	T6034	punct	),a
R3954	T6041	T6011	punct	.,found
R3955	T6043	T6044	nsubj	SEPW1,is
R3956	T6045	T6046	det	a,protein
R3957	T6046	T6044	attr	protein,is
R3958	T6047	T6048	npadvmod	selenocysteine,containing
R3959	T6048	T6046	amod	containing,protein
R3960	T6049	T6048	punct	-,containing
R3961	T6050	T6051	dep	that,binds
R3962	T6051	T6046	relcl	binds,protein
R3963	T6052	T6051	dobj	glutathione,binds
R3964	T6053	T6054	punct	(,35
R3965	T6054	T6051	parataxis	35,binds
R3966	T6055	T6054	punct	),35
R3967	T6056	T6051	cc	and,binds
R3968	T6057	T6058	auxpass	is,thought
R3969	T6058	T6051	conj	thought,binds
R3970	T6059	T6060	aux	to,act
R3971	T6060	T6058	xcomp	act,thought
R3972	T6061	T6060	prep	as,act
R3973	T6062	T6063	det	an,antioxidant
R3974	T6063	T6061	pobj	antioxidant,as
R3975	T6064	T6065	advmod	in,vivo
R3976	T6065	T6060	advmod	vivo,act
R3977	T6066	T6067	punct	(,36
R3978	T6067	T6058	parataxis	36,thought
R3979	T6068	T6067	punct	),36
R3980	T6069	T6044	punct	.,is
R3981	T6071	T6072	compound	Sepw1,expression
R3982	T6072	T6073	nsubjpass	expression,analyzed
R3983	T6074	T6072	prep	in,expression
R3984	T6075	T6074	pobj	livers,in
R3985	T6076	T6075	prep	of,livers
R3986	T6077	T6078	compound	pI,pC
R3987	T6078	T6080	npadvmod	pC,induced
R3988	T6079	T6078	punct	–,pC
R3989	T6080	T6082	amod	induced,mice
R3990	T6081	T6080	punct	-,induced
R3992	T6083	T6082	punct	", ",mice
R3993	T6084	T6085	amod	mock,treated
R3994	T6085	T6082	amod	treated,mice
R3995	T6086	T6084	punct	-,mock
R3996	T6087	T6084	cc	or,mock
R3997	T6088	T6084	conj	cadmium,mock
R3998	T6089	T6085	punct	-,treated
R3999	T6090	T6091	nmod	Mtf1Mx,cre
R4000	T6091	T6082	nmod	cre,mice
R4001	T6092	T6091	punct	-,cre
R4002	T6093	T6091	cc	and,cre
R4003	T6094	T6091	conj	Mtf1loxP,cre
R4004	T6095	T6073	auxpass	was,analyzed
R4005	T6096	T6073	advmod	further,analyzed
R4006	T6097	T6073	prep	by,analyzed
R4007	T6098	T6099	amod	semiquantitative,analysis
R4008	T6099	T6097	pobj	analysis,by
R4009	T6100	T6101	nmod	RT,PCRs
R4010	T6101	T6099	nmod	PCRs,analysis
R4011	T6102	T6101	punct	–,PCRs
R4012	T6103	T6101	cc	and,PCRs
R4013	T6104	T6101	conj	S1,PCRs
R4014	T6105	T6106	punct	(,2a
R4015	T6106	T6073	parataxis	2a,analyzed
R4016	T6107	T6106	compound	Figure,2a
R4017	T6108	T6106	cc	and,2a
R4018	T6109	T6106	conj	b,2a
R4019	T6110	T6106	punct	),2a
R4020	T6111	T6073	punct	.,analyzed
R4021	T6113	T6114	prep	In,observed
R4022	T6115	T6113	pobj	accordance,In
R4023	T6116	T6115	prep	with,accordance
R4024	T6117	T6118	compound	microarray,data
R4025	T6118	T6116	pobj	data,with
R4026	T6119	T6120	det	a,upregulation
R4027	T6120	T6114	nsubjpass	upregulation,observed
R4028	T6121	T6120	amod	slight,upregulation
R4029	T6122	T6123	punct	", ",any
R4030	T6123	T6121	parataxis	any,slight
R4031	T6124	T6123	mark	if,any
R4032	T6125	T6123	punct	", ",any
R4033	T6126	T6120	prep	of,upregulation
R4034	T6127	T6128	compound	Sepw1,transcription
R4035	T6128	T6126	pobj	transcription,of
R4036	T6129	T6114	auxpass	was,observed
R4037	T6130	T6114	prep	in,observed
R4038	T6131	T6130	pobj	livers,in
R4039	T6132	T6131	prep	from,livers
R4040	T6133	T6134	compound	Mtf1loxP,mice
R4041	T6134	T6132	pobj	mice,from
R4042	T6135	T6114	prep	upon,observed
R4043	T6136	T6137	compound	cadmium,treatment
R4044	T6137	T6135	pobj	treatment,upon
R4045	T6138	T6114	punct	.,observed
R4046	T6140	T6141	det	The,level
R4047	T6141	T6143	nsubjpass	level,reduced
R4048	T6142	T6141	amod	basal,level
R4049	T6144	T6143	auxpass	was,reduced
R4050	T6145	T6143	prep	in,reduced
R4051	T6146	T6145	pobj	livers,in
R4052	T6147	T6146	prep	from,livers
R4053	T6148	T6149	amod	mock,treated
R4054	T6149	T6154	amod	treated,mice
R4055	T6150	T6148	punct	-,mock
R4056	T6151	T6148	cc	and,mock
R4057	T6152	T6148	conj	cadmium,mock
R4058	T6153	T6149	punct	-,treated
R4059	T6154	T6147	pobj	mice,from
R4060	T6155	T6156	compound	Mtf1Mx,cre
R4061	T6156	T6154	compound	cre,mice
R4062	T6157	T6156	punct	-,cre
R4063	T6158	T6143	punct	", ",reduced
R4064	T6159	T6143	advcl	indicating,reduced
R4065	T6160	T6161	mark	that,is
R4066	T6161	T6159	ccomp	is,indicating
R4067	T6162	T6161	nsubj	MTF,is
R4068	T6163	T6162	punct	-,MTF
R4069	T6164	T6162	nummod	1,MTF
R4070	T6165	T6161	acomp	important,is
R4071	T6166	T6165	prep	for,important
R4072	T6167	T6168	det	the,expression
R4073	T6168	T6166	pobj	expression,for
R4074	T6169	T6168	amod	basal,expression
R4075	T6170	T6168	prep	of,expression
R4076	T6171	T6170	pobj	Sepw1,of
R4077	T6172	T6143	punct	.,reduced
R4078	T6174	T6175	nummod	Three,sequences
R4079	T6175	T6179	nsubjpass	sequences,found
R4080	T6176	T6175	compound	MRE,sequences
R4081	T6177	T6178	compound	core,consensus
R4082	T6178	T6175	compound	consensus,sequences
R4083	T6180	T6179	auxpass	were,found
R4084	T6181	T6179	prep	in,found
R4085	T6182	T6183	det	the,region
R4086	T6183	T6181	pobj	region,in
R4087	T6184	T6183	advmod	upstream,region
R4088	T6185	T6184	prep	of,upstream
R4089	T6186	T6187	det	the,start
R4090	T6187	T6185	pobj	start,of
R4091	T6188	T6189	compound	mouse,Sepw1
R4092	T6189	T6187	compound	Sepw1,start
R4093	T6190	T6187	compound	transcription,start
R4094	T6191	T6192	punct	(,2c
R4095	T6192	T6179	parataxis	2c,found
R4096	T6193	T6192	compound	Figure,2c
R4097	T6194	T6192	punct	),2c
R4098	T6195	T6179	punct	.,found
R4099	T6197	T6198	nsubj	Two,overlap
R4100	T6198	T6204	ccomp	overlap,located
R4101	T6199	T6197	prep	of,Two
R4102	T6200	T6199	pobj	them,of
R4103	T6201	T6197	prep	in,Two
R4104	T6202	T6203	amod	opposite,orientation
R4105	T6203	T6201	pobj	orientation,in
R4106	T6205	T6206	advmod	almost,completely
R4107	T6206	T6207	advmod	completely,proximal
R4108	T6207	T6198	advmod	proximal,overlap
R4109	T6208	T6207	prep	to,proximal
R4110	T6209	T6210	det	the,start
R4111	T6210	T6208	pobj	start,to
R4112	T6211	T6210	compound	transcription,start
R4113	T6212	T6213	punct	(,bp
R4114	T6213	T6198	parataxis	bp,overlap
R4115	T6214	T6213	dep	MRE1,bp
R4116	T6215	T6213	punct	", ",bp
R4117	T6216	T6217	punct	−,40
R4118	T6217	T6213	nummod	40,bp
R4119	T6218	T6213	punct	),bp
R4120	T6219	T6204	punct	", ",located
R4121	T6220	T6221	det	the,one
R4122	T6221	T6204	nsubjpass	one,located
R4123	T6222	T6221	amod	third,one
R4124	T6223	T6204	auxpass	is,located
R4125	T6224	T6225	advmod	further,upstream
R4126	T6225	T6204	advmod	upstream,located
R4127	T6226	T6227	punct	(,bp
R4128	T6227	T6204	parataxis	bp,located
R4129	T6228	T6227	dep	MRE2,bp
R4130	T6229	T6227	punct	", ",bp
R4131	T6230	T6231	punct	−,527
R4132	T6231	T6227	nummod	527,bp
R4133	T6232	T6227	punct	),bp
R4134	T6233	T6204	punct	.,located
R4135	T6235	T6236	amod	Specific,binding
R4136	T6236	T6237	nsubjpass	binding,observed
R4137	T6238	T6236	prep	of,binding
R4138	T6239	T6238	pobj	MTF,of
R4139	T6240	T6239	punct	-,MTF
R4140	T6241	T6239	nummod	1,MTF
R4141	T6242	T6236	prep	to,binding
R4142	T6243	T6244	nmod	Sepw1,oligonucleotide
R4143	T6244	T6242	pobj	oligonucleotide,to
R4144	T6245	T6244	nmod	MRE1,oligonucleotide
R4145	T6246	T6245	cc	but,MRE1
R4146	T6247	T6246	neg	not,but
R4147	T6248	T6245	conj	MRE2,MRE1
R4148	T6249	T6237	auxpass	was,observed
R4149	T6250	T6237	prep	in,observed
R4150	T6251	T6250	pobj	EMSA,in
R4151	T6252	T6251	prep	with,EMSA
R4152	T6253	T6254	compound	liver,protein
R4153	T6254	T6255	compound	protein,extract
R4154	T6255	T6252	pobj	extract,with
R4155	T6256	T6255	prep	from,extract
R4156	T6257	T6258	det	an,mouse
R4157	T6258	T6256	pobj	mouse,from
R4158	T6259	T6258	compound	Mtf1loxP,mouse
R4159	T6260	T6258	compound	control,mouse
R4160	T6261	T6262	punct	(,2d
R4161	T6262	T6237	parataxis	2d,observed
R4162	T6263	T6262	compound	Figure,2d
R4163	T6264	T6262	punct	),2d
R4164	T6265	T6237	punct	.,observed
R4165	T6267	T6268	prep	As,detected
R4166	T6269	T6270	det	a,control
R4167	T6270	T6267	pobj	control,As
R4168	T6271	T6268	punct	", ",detected
R4169	T6272	T6273	det	no,binding
R4170	T6273	T6268	nsubjpass	binding,detected
R4171	T6274	T6273	prep	to,binding
R4172	T6275	T6274	pobj	MRE1,to
R4173	T6276	T6268	auxpass	was,detected
R4174	T6277	T6268	prep	with,detected
R4175	T6278	T6277	pobj	extract,with
R4176	T6279	T6278	prep	from,extract
R4177	T6280	T6281	det	a,mouse
R4178	T6281	T6279	pobj	mouse,from
R4179	T6282	T6283	compound	pI,pC
R4180	T6283	T6285	npadvmod	pC,induced
R4181	T6284	T6283	punct	–,pC
R4182	T6285	T6281	amod	induced,mouse
R4183	T6286	T6285	punct	-,induced
R4184	T6287	T6288	compound	Mtf1Mx,cre
R4185	T6288	T6281	compound	cre,mouse
R4186	T6289	T6288	punct	-,cre
R4187	T6290	T6268	punct	", ",detected
R4188	T6291	T6268	advcl	confirming,detected
R4189	T6292	T6293	mark	that,was
R4190	T6293	T6291	ccomp	was,confirming
R4191	T6294	T6295	det	the,bandshift
R4192	T6295	T6293	nsubj	bandshift,was
R4193	T6296	T6293	advmod	indeed,was
R4194	T6297	T6293	acomp	dependent,was
R4195	T6298	T6297	prep	on,dependent
R4196	T6299	T6300	det	the,presence
R4197	T6300	T6298	pobj	presence,on
R4198	T6301	T6300	prep	of,presence
R4199	T6302	T6301	pobj	MTF,of
R4200	T6303	T6302	punct	-,MTF
R4201	T6304	T6302	nummod	1,MTF
R4202	T6305	T6268	punct	.,detected
R4203	T6587	T6588	compound	Cadmium,response
R4204	T6588	T6589	nsubj	response,depends
R4205	T6590	T6588	prep	of,response
R4206	T6591	T6590	pobj	Ndrg1,of
R4207	T6592	T6589	prep	on,depends
R4208	T6593	T6592	pobj	MTF,on
R4209	T6594	T6593	punct	-,MTF
R4210	T6595	T6593	nummod	1,MTF
R4211	T6597	T6598	nsubjpass	Ndrg1,downregulated
R4212	T6599	T6598	auxpass	was,downregulated
R4213	T6600	T6598	advmod	significantly,downregulated
R4214	T6601	T6598	prep	in,downregulated
R4215	T6602	T6601	pobj	microarrays,in
R4216	T6603	T6602	prep	of,microarrays
R4217	T6604	T6605	compound	liver,transcripts
R4218	T6605	T6603	pobj	transcripts,of
R4219	T6606	T6605	prep	from,transcripts
R4220	T6607	T6608	npadvmod	cadmium,treated
R4221	T6608	T6610	amod	treated,mice
R4222	T6609	T6608	punct	-,treated
R4223	T6610	T6606	pobj	mice,from
R4224	T6611	T6612	compound	Mtf1Mx,cre
R4225	T6612	T6610	compound	cre,mice
R4226	T6613	T6612	punct	-,cre
R4227	T6614	T6598	prep	compared,downregulated
R4228	T6615	T6614	prep	to,compared
R4229	T6616	T6617	advmod	similarly,treated
R4230	T6617	T6618	amod	treated,mice
R4231	T6618	T6615	pobj	mice,to
R4232	T6619	T6618	compound	Mtf1loxP,mice
R4233	T6620	T6618	compound	control,mice
R4234	T6621	T6622	punct	(,c
R4235	T6622	T6598	parataxis	c,downregulated
R4236	T6623	T6622	nmod	Table,c
R4237	T6624	T6622	nummod	1,c
R4238	T6625	T6622	punct	", ",c
R4239	T6626	T6622	punct	),c
R4240	T6627	T6598	punct	.,downregulated
R4241	T6629	T6630	nsubj	Ndrg1,has
R4242	T6631	T6630	advmod	probably,has
R4243	T6632	T6633	det	some,role
R4244	T6633	T6630	dobj	role,has
R4245	T6634	T6633	prep	in,role
R4246	T6635	T6636	compound	stress,response
R4247	T6636	T6634	pobj	response,in
R4248	T6637	T6638	mark	since,activate
R4249	T6638	T6630	advcl	activate,has
R4250	T6639	T6640	amod	various,stimuli
R4251	T6640	T6638	nsubj	stimuli,activate
R4252	T6641	T6640	punct	", ",stimuli
R4253	T6642	T6640	prep	including,stimuli
R4254	T6643	T6644	nmod	hypoxia,compounds
R4255	T6644	T6642	pobj	compounds,including
R4256	T6645	T6643	cc	and,hypoxia
R4257	T6646	T6643	conj	nickel,hypoxia
R4258	T6647	T6638	punct	", ",activate
R4259	T6648	T6638	dobj	expression,activate
R4260	T6649	T6648	prep	of,expression
R4261	T6650	T6651	compound	rodent,Ndrg1
R4262	T6651	T6649	pobj	Ndrg1,of
R4263	T6652	T6648	cc	and,expression
R4264	T6653	T6652	punct	/,and
R4265	T6654	T6652	cc	or,and
R4266	T6655	T6656	poss	its,ortholog
R4267	T6656	T6648	conj	ortholog,expression
R4268	T6657	T6656	amod	human,ortholog
R4269	T6658	T6659	punct	(,37
R4270	T6659	T6638	parataxis	37,activate
R4271	T6660	T6661	punct	–,40
R4272	T6661	T6659	prep	40,37
R4273	T6662	T6659	punct	),37
R4274	T6663	T6630	punct	.,has
R4275	T6665	T6666	det	The,results
R4276	T6666	T6669	nsubjpass	results,confirmed
R4277	T6667	T6666	compound	Ndrg1,results
R4278	T6668	T6666	compound	microarray,results
R4279	T6669	T6671	ccomp	confirmed,was
R4280	T6670	T6669	auxpass	were,confirmed
R4281	T6672	T6669	prep	with,confirmed
R4282	T6673	T6674	amod	semiquantitative,PCRs
R4283	T6674	T6672	pobj	PCRs,with
R4284	T6675	T6674	compound	RT,PCRs
R4285	T6676	T6674	punct	–,PCRs
R4286	T6677	T6678	punct	(,3a
R4287	T6678	T6669	parataxis	3a,confirmed
R4288	T6679	T6678	compound	Figure,3a
R4289	T6680	T6678	punct	),3a
R4290	T6681	T6671	punct	: ,was
R4291	T6682	T6683	prep	for,observed
R4292	T6683	T6671	ccomp	observed,was
R4293	T6684	T6685	compound	Mtf1loxP,livers
R4294	T6685	T6682	pobj	livers,for
R4295	T6686	T6685	compound	control,livers
R4296	T6687	T6683	punct	", ",observed
R4297	T6688	T6689	det	a,increase
R4298	T6689	T6683	nsubjpass	increase,observed
R4299	T6690	T6689	amod	clear,increase
R4300	T6691	T6689	prep	of,increase
R4301	T6692	T6693	compound	Ndrg1,expression
R4302	T6693	T6691	pobj	expression,of
R4303	T6694	T6683	auxpass	was,observed
R4304	T6695	T6683	prep	after,observed
R4305	T6696	T6697	compound	cadmium,exposure
R4306	T6697	T6695	pobj	exposure,after
R4307	T6698	T6671	punct	;,was
R4308	T6699	T6671	prep	in,was
R4309	T6700	T6699	pobj	livers,in
R4310	T6701	T6700	prep	from,livers
R4311	T6702	T6703	compound	Mtf1Mx,cre
R4312	T6703	T6705	compound	cre,mice
R4313	T6704	T6703	punct	-,cre
R4314	T6705	T6701	pobj	mice,from
R4315	T6706	T6671	punct	", ",was
R4316	T6707	T6708	det	this,response
R4317	T6708	T6671	nsubj	response,was
R4318	T6709	T6708	compound	cadmium,response
R4319	T6710	T6671	neg	not,was
R4320	T6711	T6671	acomp	detectable,was
R4321	T6712	T6671	punct	", ",was
R4322	T6713	T6714	mark	while,was
R4323	T6714	T6671	advcl	was,was
R4324	T6715	T6716	amod	basal,expression
R4325	T6716	T6714	nsubj	expression,was
R4326	T6717	T6714	acomp	similar,was
R4327	T6718	T6717	prep	to,similar
R4328	T6719	T6718	pobj	controls,to
R4329	T6720	T6671	punct	.,was
R4330	T6722	T6723	nsubj	This,indicates
R4331	T6724	T6725	mark	that,depends
R4332	T6725	T6723	ccomp	depends,indicates
R4333	T6726	T6727	npadvmod	cadmium,induced
R4334	T6727	T6729	amod	induced,expression
R4335	T6728	T6727	punct	-,induced
R4336	T6729	T6725	nsubj	expression,depends
R4337	T6730	T6729	prep	of,expression
R4338	T6731	T6730	pobj	Ndrg1,of
R4339	T6732	T6725	prep	on,depends
R4340	T6733	T6732	pobj	MTF,on
R4341	T6734	T6733	punct	-,MTF
R4342	T6735	T6733	nummod	1,MTF
R4343	T6736	T6723	punct	.,indicates
R4344	T6738	T6739	nummod	Five,sequences
R4345	T6739	T6743	nsubjpass	sequences,located
R4346	T6740	T6739	compound	MRE,sequences
R4347	T6741	T6739	compound	core,sequences
R4348	T6742	T6739	compound	consensus,sequences
R4349	T6744	T6743	auxpass	are,located
R4350	T6745	T6743	advmod	upstream,located
R4351	T6746	T6745	prep	of,upstream
R4352	T6747	T6748	det	the,start
R4353	T6748	T6746	pobj	start,of
R4354	T6749	T6748	compound	mouse,start
R4355	T6750	T6748	compound	Ndrg1,start
R4356	T6751	T6748	compound	transcription,start
R4357	T6752	T6753	punct	(,3b
R4358	T6753	T6743	parataxis	3b,located
R4359	T6754	T6753	compound	Figure,3b
R4360	T6755	T6753	punct	),3b
R4361	T6756	T6743	punct	.,located
R4362	T6758	T6759	nsubjpass	Four,clustered
R4363	T6759	T6763	ccomp	clustered,located
R4364	T6760	T6758	prep	of,Four
R4365	T6761	T6760	pobj	them,of
R4366	T6762	T6759	auxpass	are,clustered
R4367	T6764	T6765	punct	(,bp
R4368	T6765	T6759	parataxis	bp,clustered
R4369	T6766	T6765	dep	MRE1,bp
R4370	T6767	T6766	prep	to,MRE1
R4371	T6768	T6767	pobj	MRE4,to
R4372	T6769	T6765	punct	", ",bp
R4373	T6770	T6771	punct	−,332
R4374	T6771	T6765	nummod	332,bp
R4375	T6772	T6771	quantmod	138,332
R4376	T6773	T6771	quantmod	to,332
R4377	T6774	T6771	punct	−,332
R4378	T6775	T6765	punct	),bp
R4379	T6776	T6763	punct	", ",located
R4380	T6777	T6778	det	the,one
R4381	T6778	T6763	nsubjpass	one,located
R4382	T6779	T6778	amod	fifth,one
R4383	T6780	T6763	auxpass	is,located
R4384	T6781	T6782	advmod	farther,upstream
R4385	T6782	T6763	advmod	upstream,located
R4386	T6783	T6784	punct	(,bp
R4387	T6784	T6763	parataxis	bp,located
R4388	T6785	T6784	dep	MRE5,bp
R4389	T6786	T6784	punct	", ",bp
R4390	T6787	T6788	punct	−,883
R4391	T6788	T6784	nummod	883,bp
R4392	T6789	T6784	punct	),bp
R4393	T6790	T6763	punct	.,located
R4394	T6792	T6793	nsubjpass	EMSA,performed
R4395	T6794	T6793	auxpass	was,performed
R4396	T6795	T6796	aux	to,test
R4397	T6796	T6793	advcl	test,performed
R4398	T6797	T6798	mark	whether,interacting
R4399	T6798	T6796	ccomp	interacting,test
R4400	T6799	T6798	nsubj	MTF,interacting
R4401	T6800	T6799	punct	-,MTF
R4402	T6801	T6799	nummod	1,MTF
R4403	T6802	T6798	aux	is,interacting
R4404	T6803	T6798	prep	with,interacting
R4405	T6804	T6803	pobj	some,with
R4406	T6805	T6804	cc	or,some
R4407	T6806	T6804	conj	all,some
R4408	T6807	T6806	prep	of,all
R4409	T6808	T6809	det	the,sequences
R4410	T6809	T6807	pobj	sequences,of
R4411	T6810	T6809	nummod	four,sequences
R4412	T6811	T6809	amod	proximal,sequences
R4413	T6812	T6809	compound	MRE,sequences
R4414	T6813	T6814	punct	(,3c
R4415	T6814	T6798	parataxis	3c,interacting
R4416	T6815	T6814	compound	Figure,3c
R4417	T6816	T6814	punct	),3c
R4418	T6817	T6793	punct	.,performed
R4419	T6819	T6820	amod	Separate,oligonucleotides
R4420	T6820	T6821	nsubjpass	oligonucleotides,tested
R4421	T6822	T6821	auxpass	were,tested
R4422	T6823	T6821	prep	for,tested
R4423	T6824	T6823	pobj	MRE1,for
R4424	T6825	T6824	cc	and,MRE1
R4425	T6826	T6824	conj	MRE2,MRE1
R4426	T6827	T6821	punct	", ",tested
R4427	T6828	T6829	mark	whereas,used
R4428	T6829	T6821	advcl	used,tested
R4429	T6830	T6831	nummod	one,oligonucleotide
R4430	T6831	T6829	nsubjpass	oligonucleotide,used
R4431	T6832	T6831	acl	spanning,oligonucleotide
R4432	T6833	T6834	det	both,sequences
R4433	T6834	T6832	dobj	sequences,spanning
R4434	T6835	T6829	auxpass	was,used
R4435	T6836	T6829	prep	for,used
R4436	T6837	T6836	pobj	MRE3,for
R4437	T6838	T6837	cc	and,MRE3
R4438	T6839	T6837	conj	MRE4,MRE3
R4439	T6840	T6841	punct	(,4
R4440	T6841	T6829	parataxis	4,used
R4441	T6842	T6841	dep	MRE3,4
R4442	T6843	T6841	punct	",",4
R4443	T6844	T6841	punct	),4
R4444	T6845	T6821	punct	.,tested
R4445	T6847	T6848	det	No,complex
R4446	T6848	T6849	nsubjpass	complex,seen
R4447	T6850	T6849	auxpass	was,seen
R4448	T6851	T6849	prep	with,seen
R4449	T6852	T6851	pobj	MRE1,with
R4450	T6853	T6849	punct	", ",seen
R4451	T6854	T6849	cc	but,seen
R4452	T6855	T6856	amod	specific,complexes
R4453	T6856	T6860	nsubjpass	complexes,observed
R4454	T6857	T6856	nmod	MTF,complexes
R4455	T6858	T6857	punct	-,MTF
R4456	T6859	T6857	nummod	1,MTF
R4457	T6860	T6849	conj	observed,seen
R4458	T6861	T6860	auxpass	were,observed
R4459	T6862	T6860	prep	for,observed
R4460	T6863	T6864	preconj	both,MRE2
R4461	T6864	T6862	pobj	MRE2,for
R4462	T6865	T6864	det	the,MRE2
R4463	T6866	T6864	cc	and,MRE2
R4464	T6867	T6864	conj	MRE3,MRE2
R4465	T6868	T6864	punct	",",MRE2
R4466	T6869	T6870	nummod	4,oligonucleotides
R4467	T6870	T6864	appos	oligonucleotides,MRE2
R4468	T6871	T6870	prep	with,oligonucleotides
R4469	T6872	T6873	compound	liver,extract
R4470	T6873	T6871	pobj	extract,with
R4471	T6874	T6873	compound	protein,extract
R4472	T6875	T6873	prep	from,extract
R4473	T6876	T6877	det	an,mouse
R4474	T6877	T6875	pobj	mouse,from
R4475	T6878	T6877	compound	Mtf1loxP,mouse
R4476	T6879	T6860	punct	.,observed
R4477	T6881	T6882	mark	As,expected
R4478	T6882	T6883	advcl	expected,observed
R4479	T6884	T6883	punct	", ",observed
R4480	T6885	T6886	det	no,bandshift
R4481	T6886	T6883	nsubjpass	bandshift,observed
R4482	T6887	T6883	auxpass	was,observed
R4483	T6888	T6883	prep	with,observed
R4484	T6889	T6890	compound	protein,extract
R4485	T6890	T6888	pobj	extract,with
R4486	T6891	T6890	prep	from,extract
R4487	T6892	T6893	det	a,mouse
R4488	T6893	T6891	pobj	mouse,from
R4489	T6894	T6893	acl	lacking,mouse
R4490	T6895	T6894	dobj	MTF,lacking
R4491	T6896	T6895	punct	-,MTF
R4492	T6897	T6895	nummod	1,MTF
R4493	T6898	T6893	punct	(,mouse
R4494	T6899	T6900	compound	Mtf1Mx,cre
R4495	T6900	T6893	appos	cre,mouse
R4496	T6901	T6900	punct	-,cre
R4497	T6902	T6883	punct	),observed
R4498	T6903	T6883	punct	.,observed
R4499	T6934	T6962	punct	-,cre
R4500	T6935	T6985	pobj	proteins,of
R4501	T6936	T6937	compound	Cadmium,response
R4502	T6937	T6938	nsubj	response,depends
R4503	T6939	T6937	prep	of,response
R4504	T6940	T6939	pobj	Csrp1,of
R4505	T6941	T6938	prep	on,depends
R4506	T6942	T6941	pobj	MTF,on
R4507	T6943	T6942	punct	-,MTF
R4508	T6944	T6942	nummod	1,MTF
R4509	T6946	T6947	nsubjpass	Csrp1,found
R4510	T6948	T6947	auxpass	was,found
R4511	T6949	T6947	prep	in,found
R4512	T6950	T6951	compound	microarray,analyses
R4513	T6951	T6949	pobj	analyses,in
R4514	T6952	T6953	aux	to,downregulated
R4515	T6953	T6947	xcomp	downregulated,found
R4516	T6954	T6953	auxpass	be,downregulated
R4517	T6955	T6953	advmod	significantly,downregulated
R4518	T6956	T6953	prep	in,downregulated
R4519	T6957	T6958	npadvmod	cadmium,treated
R4520	T6958	T6960	amod	treated,mice
R4521	T6959	T6958	punct	-,treated
R4522	T6960	T6956	pobj	mice,in
R4523	T6961	T6962	compound	Mtf1Mx,cre
R4524	T6962	T6960	compound	cre,mice
R4525	T6963	T6953	prep	compared,downregulated
R4526	T6964	T6963	prep	to,compared
R4527	T6965	T6966	compound	Mtf1loxP,mice
R4528	T6966	T6964	pobj	mice,to
R4529	T6967	T6968	punct	(,c
R4530	T6968	T6953	parataxis	c,downregulated
R4531	T6969	T6968	nmod	Table,c
R4532	T6970	T6968	nummod	1,c
R4533	T6971	T6968	punct	", ",c
R4534	T6972	T6968	punct	),c
R4535	T6973	T6947	punct	.,found
R4536	T6975	T6976	nsubj	CSRP1,is
R4537	T6977	T6978	det	a,member
R4538	T6978	T6976	attr	member,is
R4539	T6979	T6978	prep	of,member
R4540	T6980	T6981	det	the,family
R4541	T6981	T6979	pobj	family,of
R4542	T6982	T6983	amod	evolutionary,conserved
R4543	T6983	T6981	amod	conserved,family
R4544	T6984	T6981	compound	CRP,family
R4545	T6985	T6981	prep	of,family
R4546	T6986	T6987	dep	that,implicated
R4547	T6987	T6935	relcl	implicated,proteins
R4548	T6988	T6987	aux	have,implicated
R4549	T6989	T6987	auxpass	been,implicated
R4550	T6990	T6987	prep	in,implicated
R4551	T6991	T6990	pobj	myogenesis,in
R4552	T6992	T6991	cc	and,myogenesis
R4553	T6993	T6994	amod	cytoskeletal,remodeling
R4554	T6994	T6991	conj	remodeling,myogenesis
R4555	T6995	T6996	punct	(,42
R4556	T6996	T6987	parataxis	42,implicated
R4557	T6997	T6996	nummod	41,42
R4558	T6998	T6996	punct	",",42
R4559	T6999	T6996	punct	),42
R4560	T7000	T6976	punct	.,is
R4561	T7002	T7003	amod	Semiquantitative,PCRs
R4562	T7003	T7006	nsubj	PCRs,confirmed
R4563	T7004	T7003	compound	RT,PCRs
R4564	T7005	T7003	punct	–,PCRs
R4565	T7007	T7008	det	the,microarray
R4566	T7008	T7006	dobj	microarray,confirmed
R4567	T7009	T7008	nmod	results,microarray
R4568	T7010	T7008	punct	", ",microarray
R4569	T7011	T7012	advmod	namely,elevated
R4570	T7012	T7008	acl	elevated,microarray
R4571	T7013	T7012	punct	", ",elevated
R4572	T7014	T7012	mark	that,elevated
R4573	T7015	T7016	compound	Csrp1,expression
R4574	T7016	T7012	nsubjpass	expression,elevated
R4575	T7017	T7012	auxpass	is,elevated
R4576	T7018	T7012	prep	in,elevated
R4577	T7019	T7020	compound	Mtf1loxP,livers
R4578	T7020	T7018	pobj	livers,in
R4579	T7021	T7012	prep	upon,elevated
R4580	T7022	T7023	compound	cadmium,exposure
R4581	T7023	T7021	pobj	exposure,upon
R4582	T7024	T7025	punct	(,4a
R4583	T7025	T7012	parataxis	4a,elevated
R4584	T7026	T7025	compound	Figure,4a
R4585	T7027	T7025	punct	),4a
R4586	T7028	T7006	punct	.,confirmed
R4587	T7030	T7031	prep	In,was
R4588	T7032	T7030	pobj	contrast,In
R4589	T7033	T7031	punct	", ",was
R4590	T7034	T7035	det	no,response
R4591	T7035	T7031	nsubj	response,was
R4592	T7036	T7035	compound	cadmium,response
R4593	T7037	T7031	acomp	detectable,was
R4594	T7038	T7031	prep	in,was
R4595	T7039	T7038	pobj	livers,in
R4596	T7040	T7039	prep	from,livers
R4597	T7041	T7042	compound	Mtf1Mx,cre
R4598	T7042	T7044	compound	cre,mice
R4599	T7043	T7042	punct	-,cre
R4600	T7044	T7040	pobj	mice,from
R4601	T7045	T7031	punct	", ",was
R4602	T7046	T7031	advcl	suggesting,was
R4603	T7047	T7048	mark	that,required
R4604	T7048	T7046	ccomp	required,suggesting
R4605	T7049	T7048	nsubjpass	MTF,required
R4606	T7050	T7049	punct	-,MTF
R4607	T7051	T7049	nummod	1,MTF
R4608	T7052	T7048	auxpass	is,required
R4609	T7053	T7048	prep	for,required
R4610	T7054	T7055	compound	cadmium,induction
R4611	T7055	T7053	pobj	induction,for
R4612	T7056	T7055	prep	of,induction
R4613	T7057	T7056	pobj	Csrp1,of
R4614	T7058	T7031	punct	.,was
R4615	T7060	T7061	nummod	Three,sequences
R4616	T7061	T7065	nsubjpass	sequences,found
R4617	T7062	T7061	compound	MRE,sequences
R4618	T7063	T7064	compound	core,consensus
R4619	T7064	T7061	compound	consensus,sequences
R4620	T7065	T7067	ccomp	found,found
R4621	T7066	T7065	auxpass	were,found
R4622	T7068	T7065	advmod	upstream,found
R4623	T7069	T7068	prep	of,upstream
R4624	T7070	T7071	det	the,start
R4625	T7071	T7069	pobj	start,of
R4626	T7072	T7073	compound	Csrp1,transcription
R4627	T7073	T7071	compound	transcription,start
R4628	T7074	T7075	punct	(,bp
R4629	T7075	T7071	parataxis	bp,start
R4630	T7076	T7075	dep	MRE2,bp
R4631	T7077	T7076	prep	to,MRE2
R4632	T7078	T7077	pobj	MRE4,to
R4633	T7079	T7075	punct	", ",bp
R4634	T7080	T7081	punct	−,56
R4635	T7081	T7082	quantmod	56,366
R4636	T7082	T7075	nummod	366,bp
R4637	T7083	T7082	quantmod	to,366
R4638	T7084	T7082	punct	−,366
R4639	T7085	T7075	punct	),bp
R4640	T7086	T7067	punct	", ",found
R4641	T7087	T7067	nsubjpass	one,found
R4642	T7088	T7067	auxpass	was,found
R4643	T7089	T7090	advmod	immediately,downstream
R4644	T7090	T7067	advmod	downstream,found
R4645	T7091	T7092	punct	(,4b
R4646	T7092	T7067	parataxis	4b,found
R4647	T7093	T7092	dep	MRE1,4b
R4648	T7094	T7093	punct	", ",MRE1
R4649	T7095	T7096	punct	+,7
R4650	T7096	T7097	nummod	7,bp
R4651	T7097	T7093	appos	bp,MRE1
R4652	T7098	T7092	punct	;,4b
R4653	T7099	T7092	compound	Figure,4b
R4654	T7100	T7092	punct	),4b
R4655	T7101	T7067	punct	.,found
R4656	T7103	T7104	amod	Specific,binding
R4657	T7104	T7105	nsubjpass	binding,observed
R4658	T7106	T7104	prep	of,binding
R4659	T7107	T7106	pobj	MTF,of
R4660	T7108	T7107	punct	-,MTF
R4661	T7109	T7107	nummod	1,MTF
R4662	T7110	T7105	auxpass	was,observed
R4663	T7111	T7105	prep	with,observed
R4664	T7112	T7111	pobj	EMSA,with
R4665	T7113	T7112	prep	for,EMSA
R4666	T7114	T7115	compound	MRE2,oligonucleotide
R4667	T7115	T7113	pobj	oligonucleotide,for
R4668	T7116	T7115	cc	and,oligonucleotide
R4669	T7117	T7118	compound	protein,extract
R4670	T7118	T7115	conj	extract,oligonucleotide
R4671	T7119	T7118	prep	from,extract
R4672	T7120	T7121	det	an,liver
R4673	T7121	T7123	nmod	liver,extract
R4674	T7122	T7121	nmod	Mtf1loxP,liver
R4675	T7123	T7119	pobj	extract,from
R4676	T7124	T7121	punct	", ",liver
R4677	T7125	T7121	cc	but,liver
R4678	T7126	T7125	neg	not,but
R4679	T7127	T7128	det	an,liver
R4680	T7128	T7121	conj	liver,liver
R4681	T7129	T7130	compound	Mtf1Mx,cre
R4682	T7130	T7128	compound	cre,liver
R4683	T7131	T7130	punct	-,cre
R4684	T7132	T7123	acl	lacking,extract
R4685	T7133	T7132	dobj	MTF,lacking
R4686	T7134	T7133	punct	-,MTF
R4687	T7135	T7133	nummod	1,MTF
R4688	T7136	T7105	punct	", ",observed
R4689	T7137	T7105	advcl	confirming,observed
R4690	T7138	T7139	det	the,participation
R4691	T7139	T7137	dobj	participation,confirming
R4692	T7140	T7139	prep	of,participation
R4693	T7141	T7140	pobj	MTF,of
R4694	T7142	T7141	punct	-,MTF
R4695	T7143	T7141	nummod	1,MTF
R4696	T7144	T7139	prep	in,participation
R4697	T7145	T7146	det	the,complex
R4698	T7146	T7144	pobj	complex,in
R4699	T7147	T7148	punct	(,4c
R4700	T7148	T7137	parataxis	4c,confirming
R4701	T7149	T7148	compound	Figure,4c
R4702	T7150	T7148	punct	),4c
R4703	T7151	T7105	punct	.,observed
R4706	T7421	T7422	nsubj	MTF,inhibits
R4707	T7423	T7421	punct	-,MTF
R4708	T7424	T7421	nummod	1,MTF
R4709	T7425	T7422	dobj	expression,inhibits
R4710	T7426	T7425	prep	of,expression
R4711	T7427	T7426	pobj	Slc39a10,of
R4712	T7429	T7430	nsubjpass	Slc39a10,detected
R4713	T7431	T7430	auxpass	was,detected
R4714	T7432	T7430	prep	in,detected
R4715	T7433	T7434	compound	microarray,analysis
R4716	T7434	T7432	pobj	analysis,in
R4717	T7435	T7436	aux	to,upregulated
R4718	T7436	T7430	xcomp	upregulated,detected
R4719	T7437	T7436	auxpass	be,upregulated
R4720	T7438	T7436	advmod	significantly,upregulated
R4721	T7439	T7436	prep	in,upregulated
R4722	T7440	T7439	pobj	livers,in
R4723	T7441	T7440	prep	from,livers
R4724	T7442	T7443	preconj	both,mock
R4725	T7443	T7444	amod	mock,treated
R4726	T7444	T7449	amod	treated,mice
R4727	T7445	T7443	punct	-,mock
R4728	T7446	T7443	cc	and,mock
R4729	T7447	T7443	conj	cadmium,mock
R4730	T7448	T7444	punct	-,treated
R4731	T7449	T7441	pobj	mice,from
R4732	T7450	T7451	compound	Mtf1Mx,cre
R4733	T7451	T7449	compound	cre,mice
R4734	T7452	T7451	punct	-,cre
R4735	T7453	T7436	prep	compared,upregulated
R4736	T7454	T7453	prep	to,compared
R4737	T7455	T7456	compound	control,animals
R4738	T7456	T7454	pobj	animals,to
R4739	T7457	T7458	punct	(,b
R4740	T7458	T7456	parataxis	b,animals
R4741	T7459	T7458	dep	Table,b
R4742	T7460	T7459	nummod	1,Table
R4743	T7461	T7458	punct	", ",b
R4744	T7462	T7458	cc	and,b
R4745	T7463	T7458	conj	d,b
R4746	T7464	T7458	punct	),b
R4747	T7465	T7430	punct	.,detected
R4748	T7467	T7468	compound	SLC39,proteins
R4749	T7468	T7469	nsubj	proteins,are
R4750	T7470	T7469	attr	members,are
R4751	T7471	T7470	prep	of,members
R4752	T7472	T7473	det	the,family
R4753	T7473	T7471	pobj	family,of
R4754	T7474	T7475	npadvmod	Zrt,like
R4755	T7475	T7480	amod	like,protein
R4756	T7476	T7474	punct	-,Zrt
R4757	T7477	T7474	cc	and,Zrt
R4758	T7478	T7474	conj	Irt,Zrt
R4759	T7479	T7475	punct	-,like
R4760	T7480	T7473	nmod	protein,family
R4761	T7481	T7480	punct	(,protein
R4762	T7482	T7480	appos	ZIP,protein
R4763	T7483	T7473	punct	),family
R4764	T7484	T7473	prep	of,family
R4765	T7485	T7486	compound	metal,transporters
R4766	T7486	T7484	pobj	transporters,of
R4767	T7487	T7486	compound	ion,transporters
R4768	T7488	T7489	dep	that,transport
R4769	T7489	T7473	relcl	transport,family
R4770	T7490	T7489	punct	", ",transport
R4771	T7491	T7489	prep	with,transport
R4772	T7492	T7493	det	no,exception
R4773	T7493	T7491	pobj	exception,with
R4774	T7494	T7493	amod	known,exception
R4775	T7495	T7489	punct	", ",transport
R4776	T7496	T7497	compound	metal,ion
R4777	T7497	T7498	compound	ion,substrates
R4778	T7498	T7489	dobj	substrates,transport
R4779	T7499	T7489	prep	across,transport
R4780	T7500	T7501	amod	cellular,membranes
R4781	T7501	T7499	pobj	membranes,across
R4782	T7502	T7489	prep	into,transport
R4783	T7503	T7504	det	the,cytoplasm
R4784	T7504	T7502	pobj	cytoplasm,into
R4785	T7505	T7506	punct	(,44
R4786	T7506	T7469	parataxis	44,are
R4787	T7507	T7506	nummod	43,44
R4788	T7508	T7506	punct	",",44
R4789	T7509	T7506	punct	),44
R4790	T7510	T7469	punct	.,are
R4791	T7512	T7513	prep	In,showed
R4792	T7514	T7512	pobj	accordance,In
R4793	T7515	T7514	prep	with,accordance
R4794	T7516	T7517	compound	microarray,data
R4795	T7517	T7515	pobj	data,with
R4796	T7518	T7513	punct	", ",showed
R4797	T7519	T7520	amod	semiquantitative,PCRs
R4798	T7520	T7513	nsubj	PCRs,showed
R4799	T7521	T7520	compound	RT,PCRs
R4800	T7522	T7520	punct	–,PCRs
R4801	T7523	T7524	det	a,downregulation
R4802	T7524	T7513	dobj	downregulation,showed
R4803	T7525	T7524	prep	of,downregulation
R4804	T7526	T7527	compound	Slc39a10,expression
R4805	T7527	T7525	pobj	expression,of
R4806	T7528	T7513	prep	in,showed
R4807	T7529	T7528	pobj	livers,in
R4808	T7530	T7529	prep	of,livers
R4809	T7531	T7532	compound	Mtf1loxP,mice
R4810	T7532	T7530	pobj	mice,of
R4811	T7533	T7513	prep	upon,showed
R4812	T7534	T7535	compound	cadmium,exposure
R4813	T7535	T7533	pobj	exposure,upon
R4814	T7536	T7513	punct	.,showed
R4815	T7538	T7539	prep	In,increased
R4816	T7539	T7552	ccomp	increased,resulted
R4817	T7540	T7538	pobj	samples,In
R4818	T7541	T7540	prep	from,samples
R4819	T7542	T7543	compound	Mtf1Mx,cre
R4820	T7543	T7545	compound	cre,mice
R4821	T7544	T7543	punct	-,cre
R4822	T7545	T7541	pobj	mice,from
R4823	T7546	T7539	punct	", ",increased
R4824	T7547	T7548	det	the,expression
R4825	T7548	T7539	nsubjpass	expression,increased
R4826	T7549	T7548	amod	basal,expression
R4827	T7550	T7539	auxpass	was,increased
R4828	T7551	T7539	advmod	significantly,increased
R4829	T7553	T7552	punct	;,resulted
R4830	T7554	T7555	compound	cadmium,treatment
R4831	T7555	T7552	nsubj	treatment,resulted
R4832	T7556	T7552	advmod	still,resulted
R4833	T7557	T7552	prep	in,resulted
R4834	T7558	T7559	det	a,decrease
R4835	T7559	T7557	pobj	decrease,in
R4836	T7560	T7559	prep	of,decrease
R4837	T7561	T7562	compound	Slc39a10,expression
R4838	T7562	T7560	pobj	expression,of
R4839	T7563	T7564	punct	(,5a
R4840	T7564	T7552	parataxis	5a,resulted
R4841	T7565	T7564	compound	Figure,5a
R4842	T7566	T7564	punct	),5a
R4843	T7567	T7552	punct	.,resulted
R4844	T7569	T7570	nsubjpass	It,judged
R4845	T7571	T7570	aux	can,judged
R4846	T7572	T7570	neg	not,judged
R4847	T7573	T7570	auxpass	be,judged
R4848	T7574	T7570	prep	by,judged
R4849	T7575	T7576	det	this,experiment
R4850	T7576	T7574	pobj	experiment,by
R4851	T7577	T7578	mark	whether,was
R4852	T7578	T7570	ccomp	was,judged
R4853	T7579	T7580	det	the,degree
R4854	T7580	T7578	nsubj	degree,was
R4855	T7581	T7580	prep	of,degree
R4856	T7582	T7583	npadvmod	cadmium,induced
R4857	T7583	T7585	amod	induced,reduction
R4858	T7584	T7583	punct	-,induced
R4859	T7585	T7581	pobj	reduction,of
R4860	T7586	T7585	prep	of,reduction
R4861	T7587	T7588	compound	Slc39a10,transcription
R4862	T7588	T7586	pobj	transcription,of
R4863	T7589	T7578	acomp	identical,was
R4864	T7590	T7589	prep	for,identical
R4865	T7591	T7592	nmod	Mtf1Mx,cre
R4866	T7592	T7594	nmod	cre,mice
R4867	T7593	T7592	punct	-,cre
R4868	T7594	T7590	pobj	mice,for
R4869	T7595	T7592	cc	and,cre
R4870	T7596	T7592	conj	Mtf1loxP,cre
R4871	T7597	T7589	cc	or,identical
R4872	T7598	T7589	conj	lower,identical
R4873	T7599	T7598	prep	in,lower
R4874	T7600	T7601	det	the,absence
R4875	T7601	T7599	pobj	absence,in
R4876	T7602	T7601	prep	of,absence
R4877	T7603	T7602	pobj	MTF,of
R4878	T7604	T7603	punct	-,MTF
R4879	T7605	T7603	nummod	1,MTF
R4880	T7606	T7570	punct	.,judged
R4881	T7608	T7609	prep	In,was
R4882	T7610	T7611	compound	microarray,analysis
R4883	T7611	T7608	pobj	analysis,In
R4884	T7612	T7609	punct	", ",was
R4885	T7613	T7614	det	the,degree
R4886	T7614	T7609	nsubj	degree,was
R4887	T7615	T7614	prep	of,degree
R4888	T7616	T7617	det	the,downregulation
R4889	T7617	T7615	pobj	downregulation,of
R4890	T7618	T7619	preconj	either,comparable
R4891	T7619	T7609	acomp	comparable,was
R4892	T7620	T7619	prep	to,comparable
R4893	T7621	T7622	det	the,one
R4894	T7622	T7620	pobj	one,to
R4895	T7623	T7622	prep	in,one
R4896	T7624	T7625	compound	control,livers
R4897	T7625	T7623	pobj	livers,in
R4898	T7626	T7619	cc	or,comparable
R4899	T7627	T7619	conj	lower,comparable
R4900	T7628	T7609	punct	", ",was
R4901	T7629	T7609	prep	depending,was
R4902	T7630	T7629	prep	on,depending
R4903	T7631	T7632	det	the,set
R4904	T7632	T7630	pobj	set,on
R4905	T7633	T7632	amod	considered,set
R4906	T7634	T7635	nmod	Affymetrix,GeneChip
R4907	T7635	T7632	nmod	GeneChip,set
R4908	T7636	T7635	punct	®,GeneChip
R4909	T7637	T7632	compound	probe,set
R4910	T7638	T7639	punct	(,shown
R4911	T7639	T7609	parataxis	shown,was
R4912	T7640	T7639	nsubj	data,shown
R4913	T7641	T7639	neg	not,shown
R4914	T7642	T7639	punct	),shown
R4915	T7643	T7609	punct	.,was
R4916	T7645	T7646	det	The,results
R4917	T7646	T7647	nsubj	results,indicate
R4918	T7648	T7649	mark	that,involved
R4919	T7649	T7647	ccomp	involved,indicate
R4920	T7650	T7649	nsubjpass	MTF,involved
R4921	T7651	T7650	punct	-,MTF
R4922	T7652	T7650	nummod	1,MTF
R4923	T7653	T7649	auxpass	is,involved
R4924	T7654	T7649	prep	in,involved
R4925	T7655	T7654	pobj	repression,in
R4926	T7656	T7655	prep	of,repression
R4927	T7657	T7658	det	the,expression
R4928	T7658	T7656	pobj	expression,of
R4929	T7659	T7658	amod	basal,expression
R4930	T7660	T7658	prep	of,expression
R4931	T7661	T7660	pobj	Slc39a10,of
R4932	T7662	T7647	punct	.,indicate
R4933	T7664	T7665	nsubj	It,participate
R4934	T7666	T7665	aux	might,participate
R4935	T7667	T7665	advmod	also,participate
R4936	T7668	T7665	prep	in,participate
R4937	T7669	T7670	det	the,response
R4938	T7670	T7668	pobj	response,in
R4939	T7671	T7670	compound	cadmium,response
R4940	T7672	T7670	prep	of,response
R4941	T7673	T7674	det	this,gene
R4942	T7674	T7672	pobj	gene,of
R4943	T7675	T7665	punct	", ",participate
R4944	T7676	T7665	cc	but,participate
R4945	T7677	T7678	nsubj	it,is
R4946	T7678	T7665	conj	is,participate
R4947	T7679	T7678	advmod	apparently,is
R4948	T7680	T7678	neg	not,is
R4949	T7681	T7682	advmod	exclusively,responsible
R4950	T7682	T7678	acomp	responsible,is
R4951	T7683	T7678	punct	.,is
R4952	T7685	T7686	nummod	One,sequence
R4953	T7686	T7690	nsubjpass	sequence,found
R4954	T7687	T7686	compound	MRE,sequence
R4955	T7688	T7689	compound	core,consensus
R4956	T7689	T7686	compound	consensus,sequence
R4957	T7690	T7692	ccomp	found,one
R4958	T7691	T7690	auxpass	was,found
R4959	T7693	T7694	advmod	just,upstream
R4960	T7694	T7690	advmod	upstream,found
R4961	T7695	T7694	prep	of,upstream
R4962	T7696	T7697	det	the,start
R4963	T7697	T7695	pobj	start,of
R4964	T7698	T7697	compound	mouse,start
R4965	T7699	T7697	compound	Slc39a10,start
R4966	T7700	T7697	compound	transcription,start
R4967	T7701	T7702	punct	(,bp
R4968	T7702	T7690	parataxis	bp,found
R4969	T7703	T7702	dep	MRE1,bp
R4970	T7704	T7702	punct	", ",bp
R4971	T7705	T7706	punct	−,21
R4972	T7706	T7702	nummod	21,bp
R4973	T7707	T7702	punct	),bp
R4974	T7708	T7692	punct	", ",one
R4975	T7709	T7692	det	another,one
R4976	T7710	T7711	advmod	directly,downstream
R4977	T7711	T7692	amod	downstream,one
R4978	T7712	T7713	punct	(,5b
R4979	T7713	T7692	parataxis	5b,one
R4980	T7714	T7713	dep	MRE2,5b
R4981	T7715	T7713	punct	", ",5b
R4982	T7716	T7717	punct	+,17
R4983	T7717	T7718	nummod	17,bp
R4984	T7718	T7713	dep	bp,5b
R4985	T7719	T7713	punct	;,5b
R4986	T7720	T7713	compound	Figure,5b
R4987	T7721	T7713	punct	),5b
R4988	T7722	T7692	punct	.,one
R4989	T7724	T7725	amod	Specific,binding
R4990	T7725	T7726	nsubjpass	binding,observed
R4991	T7727	T7725	prep	of,binding
R4992	T7728	T7727	pobj	MTF,of
R4993	T7729	T7728	punct	-,MTF
R4994	T7730	T7728	nummod	1,MTF
R4995	T7731	T7726	auxpass	was,observed
R4996	T7732	T7726	prep	in,observed
R4997	T7733	T7734	compound	EMSA,analysis
R4998	T7734	T7732	pobj	analysis,in
R4999	T7735	T7734	prep	for,analysis
R5000	T7736	T7735	pobj	MRE2,for
R5001	T7737	T7734	prep	with,analysis
R5002	T7738	T7739	compound	liver,extract
R5003	T7739	T7737	pobj	extract,with
R5004	T7740	T7739	compound	protein,extract
R5005	T7741	T7739	prep	from,extract
R5006	T7742	T7743	det	an,Mtf1loxP
R5007	T7743	T7741	pobj	Mtf1loxP,from
R5008	T7744	T7741	cc	but,from
R5009	T7745	T7744	neg	not,but
R5010	T7746	T7741	conj	from,from
R5011	T7747	T7748	det	an,mouse
R5012	T7748	T7746	pobj	mouse,from
R5013	T7749	T7750	compound	Mtf1Mx,cre
R5014	T7750	T7748	compound	cre,mouse
R5015	T7751	T7750	punct	-,cre
R5016	T7752	T7726	punct	", ",observed
R5017	T7753	T7754	mark	while,detected
R5018	T7754	T7726	advcl	detected,observed
R5019	T7755	T7756	det	no,binding
R5020	T7756	T7754	nsubjpass	binding,detected
R5021	T7757	T7754	auxpass	was,detected
R5022	T7758	T7754	prep	with,detected
R5023	T7759	T7758	pobj	MRE1,with
R5024	T7760	T7761	punct	(,5c
R5025	T7761	T7754	parataxis	5c,detected
R5026	T7762	T7761	compound	Figure,5c
R5027	T7763	T7761	punct	),5c
R5028	T7764	T7726	punct	.,observed
R5034	T8110	T8111	npadvmod	Cadmium,responsive
R5035	T8111	T8113	amod	responsive,genes
R5036	T8112	T8111	punct	-,responsive
R5037	T8114	T8113	punct	", ",genes
R5038	T8115	T8116	npadvmod	MTF,independent
R5039	T8116	T8113	amod	independent,genes
R5040	T8117	T8115	punct	-,MTF
R5041	T8118	T8115	nummod	1,MTF
R5042	T8119	T8116	punct	-,independent
R5043	T8121	T8122	advmod	Finally,identified
R5044	T8123	T8122	punct	", ",identified
R5045	T8124	T8122	nsubj	we,identified
R5046	T8125	T8122	advmod	also,identified
R5047	T8126	T8127	det	a,number
R5048	T8127	T8122	dobj	number,identified
R5049	T8128	T8127	prep	of,number
R5050	T8129	T8130	npadvmod	cadmium,responsive
R5051	T8130	T8132	amod	responsive,genes
R5052	T8131	T8130	punct	-,responsive
R5053	T8132	T8128	pobj	genes,of
R5054	T8133	T8134	dep	that,were
R5055	T8134	T8127	relcl	were,number
R5056	T8135	T8134	acomp	independent,were
R5057	T8136	T8135	prep	of,independent
R5058	T8137	T8138	nmod	MTF,presence
R5059	T8138	T8136	pobj	presence,of
R5060	T8139	T8137	punct	-,MTF
R5061	T8140	T8137	nummod	1,MTF
R5062	T8141	T8122	punct	", ",identified
R5063	T8142	T8122	prep	by,identified
R5064	T8143	T8142	pcomp	comparing,by
R5065	T8144	T8145	det	the,data
R5066	T8145	T8143	dobj	data,comparing
R5067	T8146	T8145	compound	probe,data
R5068	T8147	T8145	compound	array,data
R5069	T8148	T8145	prep	of,data
R5070	T8149	T8150	det	all,mice
R5071	T8150	T8148	pobj	mice,of
R5072	T8151	T8152	npadvmod	cadmium,treated
R5073	T8152	T8150	amod	treated,mice
R5074	T8153	T8152	punct	-,treated
R5075	T8154	T8143	prep	with,comparing
R5076	T8155	T8156	det	the,data
R5077	T8156	T8154	pobj	data,with
R5078	T8157	T8156	prep	of,data
R5079	T8158	T8159	det	all,mice
R5080	T8159	T8157	pobj	mice,of
R5081	T8160	T8161	amod	mock,treated
R5082	T8161	T8159	amod	treated,mice
R5083	T8162	T8161	punct	-,treated
R5084	T8163	T8143	punct	", ",comparing
R5085	T8164	T8143	advmod	irrespective,comparing
R5086	T8165	T8164	prep	of,irrespective
R5087	T8166	T8167	det	the,genotype
R5088	T8167	T8165	pobj	genotype,of
R5089	T8168	T8169	punct	(,Table
R5090	T8169	T8143	parataxis	Table,comparing
R5091	T8170	T8169	nummod	2,Table
R5092	T8171	T8169	punct	),Table
R5093	T8172	T8122	punct	.,identified
R5094	T8174	T8175	det	An,upregulation
R5095	T8175	T8181	nsubjpass	upregulation,observed
R5096	T8176	T8177	advmod	at,least
R5097	T8177	T8178	advmod	least,2-fold
R5098	T8178	T8175	amod	2-fold,upregulation
R5099	T8179	T8175	punct	", ",upregulation
R5100	T8180	T8175	amod	reliable,upregulation
R5101	T8182	T8181	auxpass	was,observed
R5102	T8183	T8181	prep	after,observed
R5103	T8184	T8185	compound	cadmium,exposure
R5104	T8185	T8183	pobj	exposure,after
R5105	T8186	T8181	prep	for,observed
R5106	T8187	T8188	nummod	31,sets
R5107	T8188	T8186	pobj	sets,for
R5108	T8189	T8188	compound	probe,sets
R5109	T8190	T8188	acl	corresponding,sets
R5110	T8191	T8190	prep	to,corresponding
R5111	T8192	T8193	nummod	21,genes
R5112	T8193	T8191	pobj	genes,to
R5113	T8194	T8193	amod	different,genes
R5114	T8195	T8193	amod	characterized,genes
R5115	T8196	T8197	punct	(,a
R5116	T8197	T8181	parataxis	a,observed
R5117	T8198	T8197	nmod	Table,a
R5118	T8199	T8197	nummod	2,a
R5119	T8200	T8197	punct	", ",a
R5120	T8201	T8197	punct	),a
R5121	T8202	T8181	punct	.,observed
R5122	T8204	T8205	prep	For,detected
R5123	T8206	T8207	nummod	2,sets
R5124	T8207	T8204	pobj	sets,For
R5125	T8208	T8207	compound	probe,sets
R5126	T8209	T8207	acl	corresponding,sets
R5127	T8210	T8209	prep	to,corresponding
R5128	T8211	T8212	nummod	2,genes
R5129	T8212	T8210	pobj	genes,to
R5130	T8213	T8212	amod	characterized,genes
R5131	T8214	T8205	punct	", ",detected
R5132	T8215	T8216	det	an,downregulation
R5133	T8216	T8205	nsubjpass	downregulation,detected
R5134	T8217	T8218	advmod	at,least
R5135	T8218	T8219	advmod	least,2-fold
R5136	T8219	T8216	amod	2-fold,downregulation
R5137	T8220	T8205	auxpass	was,detected
R5138	T8221	T8222	punct	(,b
R5139	T8222	T8205	parataxis	b,detected
R5140	T8223	T8222	nmod	Table,b
R5141	T8224	T8222	nummod	2,b
R5142	T8225	T8222	punct	", ",b
R5143	T8226	T8222	punct	),b
R5144	T8227	T8205	punct	.,detected
R5145	T8229	T8230	amod	Several,genes
R5146	T8230	T8231	nsubjpass	genes,found
R5147	T8232	T8230	acl	involved,genes
R5148	T8233	T8232	prep	in,involved
R5149	T8234	T8235	det	the,metabolism
R5150	T8235	T8233	pobj	metabolism,in
R5151	T8236	T8235	prep	of,metabolism
R5152	T8237	T8238	det	the,glutathione
R5153	T8238	T8236	pobj	glutathione,of
R5154	T8239	T8238	compound	antioxidant,glutathione
R5155	T8240	T8231	auxpass	were,found
R5156	T8241	T8242	aux	to,upregulated
R5157	T8242	T8231	xcomp	upregulated,found
R5158	T8243	T8242	auxpass	be,upregulated
R5159	T8244	T8242	agent	by,upregulated
R5160	T8245	T8246	compound	cadmium,exposure
R5161	T8246	T8244	pobj	exposure,by
R5162	T8247	T8242	punct	", ",upregulated
R5163	T8248	T8249	advmod	namely,genes
R5164	T8249	T8242	dobj	genes,upregulated
R5165	T8250	T8249	det	the,genes
R5166	T8251	T8249	acl	encoding,genes
R5167	T8252	T8253	det	the,subunit
R5168	T8253	T8251	dobj	subunit,encoding
R5169	T8254	T8253	amod	catalytic,subunit
R5170	T8255	T8253	prep	of,subunit
R5171	T8256	T8257	compound	glutamate,ligase
R5172	T8257	T8255	pobj	ligase,of
R5173	T8258	T8257	punct	-,ligase
R5174	T8259	T8257	compound	cysteine,ligase
R5175	T8260	T8253	punct	(,subunit
R5176	T8261	T8253	appos	Gclc,subunit
R5177	T8262	T8253	punct	),subunit
R5178	T8263	T8264	dep	that,is
R5179	T8264	T8253	relcl	is,subunit
R5180	T8265	T8266	det	the,enzyme
R5181	T8266	T8264	attr	enzyme,is
R5182	T8267	T8268	npadvmod	rate,limiting
R5183	T8268	T8266	amod	limiting,enzyme
R5184	T8269	T8266	prep	in,enzyme
R5185	T8270	T8271	advmod	de,novo
R5186	T8271	T8272	amod	novo,synthesis
R5187	T8272	T8269	pobj	synthesis,in
R5188	T8273	T8272	prep	of,synthesis
R5189	T8274	T8273	pobj	glutathione,of
R5190	T8275	T8276	punct	(,45
R5191	T8276	T8264	parataxis	45,is
R5192	T8277	T8276	punct	),45
R5193	T8278	T8249	punct	;,genes
R5194	T8279	T8280	compound	glutathione,reductase
R5195	T8280	T8249	conj	reductase,genes
R5196	T8281	T8280	nummod	1,reductase
R5197	T8282	T8280	punct	(,reductase
R5198	T8283	T8280	appos	Gsr,reductase
R5199	T8284	T8280	punct	),reductase
R5200	T8285	T8280	punct	", ",reductase
R5201	T8286	T8287	det	the,enzyme
R5202	T8287	T8280	appos	enzyme,reductase
R5203	T8288	T8287	amod	reducing,enzyme
R5204	T8289	T8287	prep	for,enzyme
R5205	T8290	T8291	amod	oxidized,glutathione
R5206	T8291	T8289	pobj	glutathione,for
R5207	T8292	T8293	punct	(,45
R5208	T8293	T8291	parataxis	45,glutathione
R5209	T8294	T8293	punct	),45
R5210	T8295	T8280	punct	;,reductase
R5211	T8296	T8280	cc	and,reductase
R5212	T8297	T8298	compound	glutathione,transferase
R5213	T8298	T8280	conj	transferase,reductase
R5214	T8299	T8298	punct	-,transferase
R5215	T8300	T8298	compound	S,transferase
R5216	T8301	T8298	punct	-,transferase
R5217	T8302	T8298	punct	", ",transferase
R5218	T8303	T8304	nmod	mu,Gstm4
R5219	T8304	T8298	appos	Gstm4,transferase
R5220	T8305	T8304	nummod	4,Gstm4
R5221	T8306	T8304	punct	(,Gstm4
R5222	T8307	T8304	punct	),Gstm4
R5223	T8308	T8298	punct	", ",transferase
R5224	T8309	T8310	dep	which,is
R5225	T8310	T8298	relcl	is,transferase
R5226	T8311	T8312	det	a,member
R5227	T8312	T8310	attr	member,is
R5228	T8313	T8312	prep	of,member
R5229	T8314	T8315	det	the,family
R5230	T8315	T8313	pobj	family,of
R5231	T8316	T8317	compound	glutathione,transferase
R5232	T8317	T8315	compound	transferase,family
R5233	T8318	T8317	punct	-,transferase
R5234	T8319	T8317	compound	S,transferase
R5235	T8320	T8317	punct	-,transferase
R5236	T8321	T8315	compound	supergene,family
R5237	T8322	T8315	prep	of,family
R5238	T8323	T8324	compound	detoxification,enzymes
R5239	T8324	T8322	pobj	enzymes,of
R5240	T8325	T8326	punct	(,45
R5241	T8326	T8312	parataxis	45,member
R5242	T8327	T8326	punct	),45
R5243	T8328	T8231	punct	.,found
R5244	T8330	T8331	prep	In,confirmed
R5245	T8332	T8330	pobj	all,In
R5246	T8333	T8332	prep	of,all
R5247	T8334	T8335	det	these,cases
R5248	T8335	T8333	pobj	cases,of
R5249	T8336	T8331	punct	", ",confirmed
R5250	T8337	T8331	nsubjpass	induction,confirmed
R5251	T8338	T8331	auxpass	was,confirmed
R5252	T8339	T8331	agent	by,confirmed
R5253	T8340	T8341	amod	semiquantitative,PCRs
R5254	T8341	T8339	pobj	PCRs,by
R5255	T8342	T8341	compound	RT,PCRs
R5256	T8343	T8341	punct	–,PCRs
R5257	T8344	T8345	punct	(,shown
R5258	T8345	T8331	parataxis	shown,confirmed
R5259	T8346	T8345	nsubj	data,shown
R5260	T8347	T8345	neg	not,shown
R5261	T8348	T8345	punct	),shown
R5262	T8349	T8331	punct	.,confirmed
R5263	T8351	T8352	nsubjpass	Gclc,discussed
R5264	T8353	T8351	punct	", ",Gclc
R5265	T8354	T8355	advmod	also,referred
R5266	T8355	T8351	acl	referred,Gclc
R5267	T8356	T8355	prep	to,referred
R5268	T8357	T8355	prep	as,referred
R5269	T8358	T8359	amod	heavy,chain
R5270	T8359	T8360	compound	chain,subunit
R5271	T8360	T8357	pobj	subunit,as
R5272	T8361	T8360	prep	of,subunit
R5273	T8362	T8363	compound	gamma,glutamylcysteine
R5274	T8363	T8365	compound	glutamylcysteine,synthetase
R5275	T8364	T8363	punct	-,glutamylcysteine
R5276	T8365	T8361	pobj	synthetase,of
R5277	T8366	T8360	punct	(,subunit
R5278	T8367	T8368	compound	Ggcs,hc
R5279	T8368	T8360	appos	hc,subunit
R5280	T8369	T8368	punct	-,hc
R5281	T8370	T8352	punct	),discussed
R5282	T8371	T8352	punct	", ",discussed
R5283	T8372	T8352	aux	had,discussed
R5284	T8373	T8352	auxpass	been,discussed
R5285	T8374	T8352	advmod	previously,discussed
R5286	T8375	T8352	prep	as,discussed
R5287	T8376	T8377	det	a,gene
R5288	T8377	T8375	pobj	gene,as
R5289	T8378	T8377	compound	target,gene
R5290	T8379	T8377	prep	of,gene
R5291	T8380	T8379	pobj	MTF,of
R5292	T8381	T8380	punct	-,MTF
R5293	T8382	T8380	nummod	1,MTF
R5294	T8383	T8384	punct	(,6
R5295	T8384	T8352	parataxis	6,discussed
R5296	T8385	T8384	punct	),6
R5297	T8386	T8352	punct	.,discussed
R5298	T8388	T8389	poss	Our,data
R5299	T8389	T8391	nsubj	data,indicate
R5300	T8390	T8389	compound	expression,data
R5301	T8392	T8393	mark	that,induced
R5302	T8393	T8391	ccomp	induced,indicate
R5303	T8394	T8393	nsubjpass	Gclc,induced
R5304	T8395	T8393	auxpass	is,induced
R5305	T8396	T8393	agent	by,induced
R5306	T8397	T8396	pobj	cadmium,by
R5307	T8398	T8393	cc	but,induced
R5308	T8399	T8393	punct	", ",induced
R5309	T8400	T8401	advmod	at,least
R5310	T8401	T8402	advmod	least,in
R5311	T8402	T8403	prep	in,dependent
R5312	T8403	T8393	amod	dependent,induced
R5313	T8404	T8405	det	the,liver
R5314	T8405	T8402	pobj	liver,in
R5315	T8406	T8405	amod	adult,liver
R5316	T8407	T8405	compound	mouse,liver
R5317	T8408	T8403	punct	", ",dependent
R5318	T8409	T8403	neg	not,dependent
R5319	T8410	T8403	prep	on,dependent
R5320	T8411	T8410	pobj	MTF,on
R5321	T8412	T8411	punct	-,MTF
R5322	T8413	T8411	nummod	1,MTF
R5323	T8414	T8391	punct	.,indicate
R5324	T8416	T8417	aux	To,analyze
R5325	T8417	T8418	advcl	analyze,treated
R5326	T8419	T8420	det	the,role
R5327	T8420	T8417	dobj	role,analyze
R5328	T8421	T8420	prep	of,role
R5329	T8422	T8423	det	the,system
R5330	T8423	T8421	pobj	system,of
R5331	T8424	T8423	compound	glutathione,system
R5332	T8425	T8420	prep	in,role
R5333	T8426	T8427	det	the,response
R5334	T8427	T8425	pobj	response,in
R5335	T8428	T8427	amod	cellular,response
R5336	T8429	T8427	compound	cadmium,response
R5337	T8430	T8418	punct	", ",treated
R5338	T8431	T8432	nmod	mouse,fibroblasts
R5339	T8432	T8418	nsubjpass	fibroblasts,treated
R5340	T8433	T8432	amod	embryonic,fibroblasts
R5341	T8434	T8432	prep	with,fibroblasts
R5342	T8435	T8434	cc	and,with
R5343	T8436	T8434	conj	without,with
R5344	T8437	T8438	amod	functional,Mtf1
R5345	T8438	T8436	pobj	Mtf1,without
R5346	T8439	T8418	auxpass	were,treated
R5347	T8440	T8418	prep	with,treated
R5348	T8441	T8440	pobj	cadmium,with
R5349	T8442	T8418	prep	in,treated
R5350	T8443	T8442	pobj	combination,in
R5351	T8444	T8443	prep	with,combination
R5352	T8445	T8444	pobj	BSO,with
R5353	T8446	T8445	punct	", ",BSO
R5354	T8447	T8448	det	a,inhibitor
R5355	T8448	T8445	appos	inhibitor,BSO
R5356	T8449	T8448	amod	specific,inhibitor
R5357	T8450	T8448	prep	of,inhibitor
R5358	T8451	T8452	compound	glutamate,cysteine
R5359	T8452	T8454	compound	cysteine,ligase
R5360	T8453	T8452	punct	-,cysteine
R5361	T8454	T8450	pobj	ligase,of
R5362	T8455	T8456	punct	(,31
R5363	T8456	T8454	parataxis	31,ligase
R5364	T8457	T8456	punct	),31
R5365	T8458	T8418	punct	", ",treated
R5366	T8459	T8418	cc	and,treated
R5367	T8460	T8461	compound	cell,viability
R5368	T8461	T8462	nsubjpass	viability,assessed
R5369	T8462	T8418	conj	assessed,treated
R5370	T8463	T8462	auxpass	was,assessed
R5371	T8464	T8462	agent	by,assessed
R5372	T8465	T8466	det	a,assay
R5373	T8466	T8464	pobj	assay,by
R5374	T8467	T8466	amod	colorimetric,assay
R5375	T8468	T8466	prep	based,assay
R5376	T8469	T8468	prep	on,based
R5377	T8470	T8471	det	the,salt
R5378	T8471	T8469	pobj	salt,on
R5379	T8472	T8471	compound	tetrazolium,salt
R5380	T8473	T8471	appos	MTT,salt
R5381	T8474	T8475	punct	(,Figure
R5382	T8475	T8462	parataxis	Figure,assessed
R5383	T8476	T8475	nummod	6,Figure
R5384	T8477	T8475	punct	),Figure
R5385	T8478	T8462	punct	.,assessed
R5386	T8480	T8481	amod	Increasing,concentrations
R5387	T8481	T8482	nsubj	concentrations,were
R5388	T8483	T8481	prep	of,concentrations
R5389	T8484	T8483	pobj	BSO,of
R5390	T8485	T8484	cc	or,BSO
R5391	T8486	T8484	conj	cadmium,BSO
R5392	T8487	T8484	advmod	alone,BSO
R5393	T8488	T8482	prep	to,were
R5394	T8489	T8490	det	some,extent
R5395	T8490	T8488	pobj	extent,to
R5396	T8491	T8482	acomp	cytotoxic,were
R5397	T8492	T8491	prep	for,cytotoxic
R5398	T8493	T8494	det	the,lines
R5399	T8494	T8492	pobj	lines,for
R5400	T8495	T8494	amod	examined,lines
R5401	T8496	T8494	compound	cell,lines
R5402	T8497	T8482	punct	.,were
R5403	T8499	T8500	nsubj	Treatment,resulted
R5404	T8501	T8499	prep	with,Treatment
R5405	T8502	T8503	preconj	both,BSO
R5406	T8503	T8501	pobj	BSO,with
R5407	T8504	T8503	cc	and,BSO
R5408	T8505	T8503	conj	cadmium,BSO
R5409	T8506	T8500	prep	in,resulted
R5410	T8507	T8508	det	an,lethality
R5411	T8508	T8506	pobj	lethality,in
R5412	T8509	T8508	amod	enhanced,lethality
R5413	T8510	T8511	advmod	particularly,for
R5414	T8511	T8500	prep	for,resulted
R5415	T8512	T8513	det	the,cells
R5416	T8513	T8511	pobj	cells,for
R5417	T8514	T8513	prep	without,cells
R5418	T8515	T8516	amod	functional,Mtf1
R5419	T8516	T8514	pobj	Mtf1,without
R5420	T8517	T8500	punct	", ",resulted
R5421	T8518	T8500	advcl	indicating,resulted
R5422	T8519	T8520	mark	that,impair
R5423	T8520	T8518	ccomp	impair,indicating
R5424	T8521	T8522	det	a,depletion
R5425	T8522	T8520	nsubj	depletion,impair
R5426	T8523	T8522	prep	of,depletion
R5427	T8524	T8523	pobj	glutathione,of
R5428	T8525	T8522	advmod	together,depletion
R5429	T8526	T8525	prep	with,together
R5430	T8527	T8528	det	a,lack
R5431	T8528	T8526	pobj	lack,with
R5432	T8529	T8528	prep	of,lack
R5433	T8530	T8529	pobj	Mtf1,of
R5434	T8531	T8532	det	an,defense
R5435	T8532	T8520	dobj	defense,impair
R5436	T8533	T8532	amod	efficient,defense
R5437	T8534	T8532	amod	anti-cadmium,defense
R5438	T8535	T8500	punct	.,resulted
R5439	T8537	T8538	advmod	Thus,are
R5440	T8539	T8538	punct	", ",are
R5441	T8540	T8541	amod	adequate,supply
R5442	T8541	T8538	nsubj	supply,are
R5443	T8542	T8541	compound	glutathione,supply
R5444	T8543	T8544	advmod	as,as
R5445	T8544	T8541	cc	as,supply
R5446	T8545	T8544	advmod	well,as
R5447	T8546	T8541	conj	MTF,supply
R5448	T8547	T8546	punct	-,MTF
R5449	T8548	T8546	nummod	1,MTF
R5450	T8549	T8541	cc	and,supply
R5451	T8550	T8551	poss	its,genes
R5452	T8551	T8541	conj	genes,supply
R5453	T8552	T8551	compound	target,genes
R5454	T8553	T8538	acomp	essential,are
R5455	T8554	T8553	prep	for,essential
R5456	T8555	T8556	det	the,survival
R5457	T8556	T8554	pobj	survival,for
R5458	T8557	T8556	prep	of,survival
R5459	T8558	T8559	det	the,cell
R5460	T8559	T8557	pobj	cell,of
R5461	T8560	T8556	prep	under,survival
R5462	T8561	T8562	compound	cadmium,stress
R5463	T8562	T8560	pobj	stress,under
R5464	T8563	T8538	punct	.,are
R5465	T8565	T8566	prep	Besides,upregulated
R5466	T8567	T8565	pobj	genes,Besides
R5467	T8568	T8567	acl	related,genes
R5468	T8569	T8568	prep	to,related
R5469	T8570	T8571	det	the,pathway
R5470	T8571	T8569	pobj	pathway,to
R5471	T8572	T8571	compound	glutathione,pathway
R5472	T8573	T8566	punct	", ",upregulated
R5473	T8574	T8575	amod	several,genes
R5474	T8575	T8566	nsubjpass	genes,upregulated
R5475	T8576	T8575	amod	other,genes
R5476	T8577	T8578	npadvmod	stress,related
R5477	T8578	T8575	amod	related,genes
R5478	T8579	T8578	punct	-,related
R5479	T8580	T8566	auxpass	were,upregulated
R5480	T8581	T8566	prep	upon,upregulated
R5481	T8582	T8583	compound	cadmium,exposure
R5482	T8583	T8581	pobj	exposure,upon
R5483	T8584	T8566	punct	", ",upregulated
R5484	T8585	T8566	prep	including,upregulated
R5485	T8586	T8585	pobj	genes,including
R5486	T8587	T8586	prep	for,genes
R5487	T8588	T8589	compound	thioredoxin,reductase
R5488	T8589	T8587	pobj	reductase,for
R5489	T8590	T8589	nummod	1,reductase
R5490	T8591	T8589	punct	(,reductase
R5491	T8592	T8589	appos	Txnrd1,reductase
R5492	T8593	T8589	punct	),reductase
R5493	T8594	T8589	punct	", ",reductase
R5494	T8595	T8589	appos	one,reductase
R5495	T8596	T8595	prep	of,one
R5496	T8597	T8598	det	the,enzymes
R5497	T8598	T8596	pobj	enzymes,of
R5498	T8599	T8598	amod	reducing,enzymes
R5499	T8600	T8595	prep	of,one
R5500	T8601	T8602	det	the,thioredoxin
R5501	T8602	T8600	pobj	thioredoxin,of
R5502	T8603	T8602	compound	antioxidant,thioredoxin
R5503	T8604	T8605	punct	(,46
R5504	T8605	T8602	parataxis	46,thioredoxin
R5505	T8606	T8605	punct	),46
R5506	T8607	T8589	punct	;,reductase
R5507	T8608	T8609	nmod	KDEL,receptor
R5508	T8609	T8589	conj	receptor,reductase
R5509	T8610	T8609	amod	endoplasmic,receptor
R5510	T8611	T8609	compound	reticulum,receptor
R5511	T8612	T8609	compound	protein,receptor
R5512	T8613	T8609	compound	retention,receptor
R5513	T8614	T8609	nummod	2,receptor
R5514	T8615	T8609	punct	(,receptor
R5515	T8616	T8609	appos	Kdelr2,receptor
R5516	T8617	T8609	punct	),receptor
R5517	T8618	T8609	acl	participating,receptor
R5518	T8619	T8618	prep	in,participating
R5519	T8620	T8621	compound	ER,response
R5520	T8621	T8619	pobj	response,in
R5521	T8622	T8621	compound	stress,response
R5522	T8623	T8624	punct	(,47
R5523	T8624	T8621	parataxis	47,response
R5524	T8625	T8624	punct	),47
R5525	T8626	T8609	punct	;,receptor
R5526	T8627	T8609	cc	and,receptor
R5527	T8628	T8629	det	the,athanogene
R5528	T8629	T8609	conj	athanogene,receptor
R5529	T8630	T8629	amod	anti-apoptotic,athanogene
R5530	T8631	T8629	nmod	Bcl2,athanogene
R5531	T8632	T8629	punct	-,athanogene
R5532	T8633	T8629	amod	associated,athanogene
R5533	T8634	T8629	nummod	3,athanogene
R5534	T8635	T8629	punct	(,athanogene
R5535	T8636	T8629	appos	Bag3,athanogene
R5536	T8637	T8629	punct	),athanogene
R5537	T8638	T8629	acl	involved,athanogene
R5538	T8639	T8638	prep	in,involved
R5539	T8640	T8641	npadvmod	stress,induced
R5540	T8641	T8643	amod	induced,apoptosis
R5541	T8642	T8641	punct	-,induced
R5542	T8643	T8639	pobj	apoptosis,in
R5543	T8644	T8645	punct	(,48
R5544	T8645	T8643	parataxis	48,apoptosis
R5545	T8646	T8645	punct	),48
R5546	T8647	T8566	punct	.,upregulated
R5563	T9786	T9787	prep	In,affect
R5564	T9788	T9789	det	this,study
R5565	T9789	T9786	pobj	study,In
R5566	T9790	T9787	punct	", ",affect
R5567	T9791	T9792	det	a,deletion
R5568	T9792	T9787	nsubj	deletion,affect
R5569	T9793	T9794	advmod	virtually,complete
R5570	T9794	T9792	amod	complete,deletion
R5571	T9795	T9792	prep	of,deletion
R5572	T9796	T9795	pobj	Mtf1,of
R5573	T9797	T9792	prep	in,deletion
R5574	T9798	T9799	det	the,liver
R5575	T9799	T9797	pobj	liver,in
R5576	T9800	T9799	prep	of,liver
R5577	T9801	T9802	amod	adult,mice
R5578	T9802	T9800	pobj	mice,of
R5579	T9803	T9802	punct	", ",mice
R5580	T9804	T9805	compound	pI,pC
R5581	T9805	T9807	npadvmod	pC,induced
R5582	T9806	T9805	punct	–,pC
R5583	T9807	T9802	amod	induced,mice
R5584	T9808	T9807	punct	-,induced
R5585	T9809	T9810	compound	Mtf1Mx,cre
R5586	T9810	T9802	compound	cre,mice
R5587	T9811	T9810	punct	-,cre
R5588	T9812	T9787	aux	did,affect
R5589	T9813	T9787	neg	not,affect
R5590	T9814	T9787	advmod	detectably,affect
R5591	T9815	T9816	det	the,phenotype
R5592	T9816	T9787	dobj	phenotype,affect
R5593	T9817	T9816	prep	of,phenotype
R5594	T9818	T9819	det	the,mice
R5595	T9819	T9817	pobj	mice,of
R5596	T9820	T9819	amod	respective,mice
R5597	T9821	T9816	prep	under,phenotype
R5598	T9822	T9823	amod	non-stress,conditions
R5599	T9823	T9821	pobj	conditions,under
R5600	T9824	T9787	punct	", ",affect
R5601	T9825	T9787	advcl	confirming,affect
R5602	T9826	T9827	mark	that,is
R5603	T9827	T9825	ccomp	is,confirming
R5604	T9828	T9827	nsubj	MTF,is
R5605	T9829	T9828	punct	-,MTF
R5606	T9830	T9828	nummod	1,MTF
R5607	T9831	T9827	acomp	dispensable,is
R5608	T9832	T9827	prep	in,is
R5609	T9833	T9834	det	the,liver
R5610	T9834	T9832	pobj	liver,in
R5611	T9835	T9834	amod	adult,liver
R5612	T9836	T9837	punct	(,26
R5613	T9837	T9827	parataxis	26,is
R5614	T9838	T9837	punct	),26
R5615	T9839	T9787	punct	", ",affect
R5616	T9840	T9787	prep	in,affect
R5617	T9841	T9840	pobj	contrast,in
R5618	T9842	T9841	prep	to,contrast
R5619	T9843	T9844	poss	its,role
R5620	T9844	T9842	pobj	role,to
R5621	T9845	T9844	amod	essential,role
R5622	T9846	T9844	prep	in,role
R5623	T9847	T9848	amod	embryonic,development
R5624	T9848	T9846	pobj	development,in
R5625	T9849	T9848	compound	liver,development
R5626	T9850	T9851	punct	(,23
R5627	T9851	T9844	parataxis	23,role
R5628	T9852	T9851	punct	),23
R5629	T9853	T9787	punct	.,affect
R5630	T9855	T9856	det	The,comparison
R5631	T9856	T9857	nsubj	comparison,revealed
R5632	T9858	T9856	prep	of,comparison
R5633	T9859	T9860	compound	gene,expression
R5634	T9860	T9858	pobj	expression,of
R5635	T9861	T9856	prep	in,comparison
R5636	T9862	T9861	pobj	livers,in
R5637	T9863	T9862	prep	of,livers
R5638	T9864	T9865	amod	mock,treated
R5639	T9865	T9870	amod	treated,mice
R5640	T9866	T9864	punct	-,mock
R5641	T9867	T9864	cc	or,mock
R5642	T9868	T9864	conj	cadmium,mock
R5643	T9869	T9865	punct	-,treated
R5644	T9870	T9863	pobj	mice,of
R5645	T9871	T9872	nmod	Mtf1Mx,cre
R5646	T9872	T9870	nmod	cre,mice
R5647	T9873	T9872	punct	-,cre
R5648	T9874	T9872	cc	and,cre
R5649	T9875	T9872	conj	Mtf1loxP,cre
R5650	T9876	T9877	amod	several,candidates
R5651	T9877	T9857	dobj	candidates,revealed
R5652	T9878	T9877	nmod	MTF,candidates
R5653	T9879	T9878	punct	-,MTF
R5654	T9880	T9878	nummod	1,MTF
R5655	T9881	T9877	compound	target,candidates
R5656	T9882	T9877	compound	gene,candidates
R5657	T9883	T9857	punct	.,revealed
R5658	T9885	T9886	nsubjpass	Transcripts,reduced
R5659	T9887	T9885	prep	of,Transcripts
R5660	T9888	T9889	det	the,genes
R5661	T9889	T9887	pobj	genes,of
R5662	T9890	T9889	nummod	two,genes
R5663	T9891	T9892	npadvmod	stress,responsive
R5664	T9892	T9889	amod	responsive,genes
R5665	T9893	T9892	punct	-,responsive
R5666	T9894	T9889	compound	metallothionein,genes
R5667	T9895	T9889	appos	Mt1,genes
R5668	T9896	T9895	cc	and,Mt1
R5669	T9897	T9895	conj	Mt2,Mt1
R5670	T9898	T9886	auxpass	were,reduced
R5671	T9899	T9886	advmod	severely,reduced
R5672	T9900	T9886	punct	", ",reduced
R5673	T9901	T9886	prep	in,reduced
R5674	T9902	T9901	pobj	support,in
R5675	T9903	T9902	prep	of,support
R5676	T9904	T9905	det	a,role
R5677	T9905	T9903	pobj	role,of
R5678	T9906	T9905	amod	crucial,role
R5679	T9907	T9905	prep	of,role
R5680	T9908	T9907	pobj	MTF,of
R5681	T9909	T9908	punct	-,MTF
R5682	T9910	T9908	nummod	1,MTF
R5683	T9911	T9905	prep	for,role
R5684	T9912	T9913	preconj	both,expression
R5685	T9913	T9911	pobj	expression,for
R5686	T9914	T9913	amod	basal,expression
R5687	T9915	T9914	cc	and,basal
R5688	T9916	T9917	npadvmod	metal,induced
R5689	T9917	T9914	conj	induced,basal
R5690	T9918	T9917	punct	-,induced
R5691	T9919	T9913	prep	of,expression
R5692	T9920	T9919	pobj	metallothioneins,of
R5693	T9921	T9922	punct	(,6
R5694	T9922	T9886	parataxis	6,reduced
R5695	T9923	T9922	nummod	4,6
R5696	T9924	T9922	punct	",",6
R5697	T9925	T9922	punct	),6
R5698	T9926	T9886	punct	.,reduced
R5699	T9928	T9929	nsubj	One,is
R5700	T9930	T9928	prep	of,One
R5701	T9931	T9932	det	the,genes
R5702	T9932	T9930	pobj	genes,of
R5703	T9933	T9934	advmod	newly,found
R5704	T9934	T9932	amod	found,genes
R5705	T9935	T9932	compound	target,genes
R5706	T9936	T9929	attr	Sepw1,is
R5707	T9937	T9929	punct	.,is
R5708	T9939	T9940	det	The,function
R5709	T9940	T9943	nsubj	function,is
R5710	T9941	T9940	amod	exact,function
R5711	T9942	T9940	amod	molecular,function
R5712	T9944	T9940	prep	of,function
R5713	T9945	T9946	compound	SEPW1,protein
R5714	T9946	T9944	pobj	protein,of
R5715	T9947	T9943	acomp	unknown,is
R5716	T9948	T9943	prep	to,is
R5717	T9949	T9948	pobj	date,to
R5718	T9950	T9943	punct	", ",is
R5719	T9951	T9943	cc	but,is
R5720	T9952	T9953	det	a,role
R5721	T9953	T9954	nsubjpass	role,proposed
R5722	T9954	T9943	conj	proposed,is
R5723	T9955	T9953	prep	as,role
R5724	T9956	T9955	pobj	antioxidant,as
R5725	T9957	T9954	aux	has,proposed
R5726	T9958	T9954	auxpass	been,proposed
R5727	T9959	T9954	prep	due,proposed
R5728	T9960	T9959	pcomp	to,due
R5729	T9961	T9962	poss	its,ability
R5730	T9962	T9959	pobj	ability,due
R5731	T9963	T9964	aux	to,bind
R5732	T9964	T9962	acl	bind,ability
R5733	T9965	T9964	dobj	glutathione,bind
R5734	T9966	T9967	punct	(,35
R5735	T9967	T9954	parataxis	35,proposed
R5736	T9968	T9967	punct	),35
R5737	T9969	T9954	punct	.,proposed
R5738	T9971	T9972	prep	In,renders
R5739	T9973	T9971	pobj	accordance,In
R5740	T9974	T9973	prep	with,accordance
R5741	T9975	T9974	pobj	this,with
R5742	T9976	T9972	punct	", ",renders
R5743	T9977	T9978	amod	ectopic,expression
R5744	T9978	T9972	nsubj	expression,renders
R5745	T9979	T9978	prep	of,expression
R5746	T9980	T9981	compound	mouse,Sepw1
R5747	T9981	T9979	pobj	Sepw1,of
R5748	T9982	T9972	dobj	cells,renders
R5749	T9983	T9972	oprd	resistant,renders
R5750	T9984	T9983	prep	to,resistant
R5751	T9985	T9986	compound	hydrogen,peroxide
R5752	T9986	T9984	pobj	peroxide,to
R5753	T9987	T9972	punct	", ",renders
R5754	T9988	T9972	cc	and,renders
R5755	T9989	T9990	det	this,resistance
R5756	T9990	T9991	nsubj	resistance,is
R5757	T9991	T9972	conj	is,renders
R5758	T9992	T9991	acomp	dependent,is
R5759	T9993	T9992	prep	on,dependent
R5760	T9994	T9995	nmod	it,glutathione
R5761	T9995	T9993	pobj	glutathione,on
R5762	T9996	T9995	amod	binding,glutathione
R5763	T9997	T9998	punct	(,36
R5764	T9998	T9991	parataxis	36,is
R5765	T9999	T9998	punct	),36
R5766	T10000	T9991	punct	.,is
R5767	T10002	T10003	advmod	Furthermore,showed
R5768	T10004	T10003	punct	", ",showed
R5769	T10005	T10003	nsubj	Amantana,showed
R5770	T10006	T10005	nmod	et,Amantana
R5771	T10007	T10005	nmod	al.,Amantana
R5772	T10008	T10009	punct	(,49
R5773	T10009	T10005	parataxis	49,Amantana
R5774	T10010	T10009	punct	),49
R5775	T10011	T10012	mark	that,induced
R5776	T10012	T10003	ccomp	induced,showed
R5777	T10013	T10012	nsubjpass	expression,induced
R5778	T10014	T10013	prep	of,expression
R5779	T10015	T10016	det	a,gene
R5780	T10016	T10014	pobj	gene,of
R5781	T10017	T10016	compound	reporter,gene
R5782	T10018	T10016	acl	fused,gene
R5783	T10019	T10018	prep	to,fused
R5784	T10020	T10021	det	a,fragment
R5785	T10021	T10019	pobj	fragment,to
R5786	T10022	T10021	compound	rat,fragment
R5787	T10023	T10021	compound	Sepw1,fragment
R5788	T10024	T10021	compound	promoter,fragment
R5789	T10025	T10012	aux	can,induced
R5790	T10026	T10012	auxpass	be,induced
R5791	T10027	T10012	prep	in,induced
R5792	T10028	T10029	nmod	rat,cells
R5793	T10029	T10027	pobj	cells,in
R5794	T10030	T10029	amod	glial,cells
R5795	T10031	T10012	agent	by,induced
R5796	T10032	T10031	pobj	copper,by
R5797	T10033	T10032	cc	and,copper
R5798	T10034	T10032	conj	zinc,copper
R5799	T10035	T10034	punct	", ",zinc
R5800	T10036	T10034	cc	but,zinc
R5801	T10037	T10036	neg	not,but
R5802	T10038	T10034	conj	cadmium,zinc
R5803	T10039	T10003	punct	.,showed
R5804	T10041	T10042	det	This,response
R5805	T10042	T10043	nsubj	response,was
R5806	T10044	T10043	acomp	dependent,was
R5807	T10045	T10044	prep	on,dependent
R5808	T10046	T10047	det	an,sequence
R5809	T10047	T10045	pobj	sequence,on
R5810	T10048	T10049	amod	overlapping,inverted
R5811	T10049	T10047	amod	inverted,sequence
R5812	T10050	T10049	punct	-,inverted
R5813	T10051	T10047	compound	MRE,sequence
R5814	T10052	T10047	acl	located,sequence
R5815	T10053	T10052	advmod	proximal,located
R5816	T10054	T10053	prep	to,proximal
R5817	T10055	T10056	det	the,start
R5818	T10056	T10054	pobj	start,to
R5819	T10057	T10056	compound	rat,start
R5820	T10058	T10056	compound	Sepw1,start
R5821	T10059	T10056	compound	transcription,start
R5822	T10060	T10061	punct	(,49
R5823	T10061	T10056	parataxis	49,start
R5824	T10062	T10061	punct	),49
R5825	T10063	T10043	punct	", ",was
R5826	T10064	T10065	advmod	even,failed
R5827	T10065	T10043	advcl	failed,was
R5828	T10066	T10065	mark	though,failed
R5829	T10067	T10068	amod	initial,studies
R5830	T10068	T10065	nsubj	studies,failed
R5831	T10069	T10070	aux	to,demonstrate
R5832	T10070	T10065	xcomp	demonstrate,failed
R5833	T10071	T10072	nmod	MTF,binding
R5834	T10072	T10070	dobj	binding,demonstrate
R5835	T10073	T10071	punct	-,MTF
R5836	T10074	T10071	nummod	1,MTF
R5837	T10075	T10072	prep	to,binding
R5838	T10076	T10077	det	that,sequence
R5839	T10077	T10075	pobj	sequence,to
R5840	T10078	T10079	punct	(,50
R5841	T10079	T10070	parataxis	50,demonstrate
R5842	T10080	T10079	punct	),50
R5843	T10081	T10043	punct	.,was
R5844	T10083	T10084	poss	Our,expression
R5845	T10084	T10085	nsubj	expression,suggest
R5846	T10086	T10084	cc	and,expression
R5847	T10087	T10088	npadvmod	DNA,binding
R5848	T10088	T10090	amod	binding,studies
R5849	T10089	T10088	punct	-,binding
R5850	T10090	T10084	conj	studies,expression
R5851	T10091	T10085	advmod	strongly,suggest
R5852	T10092	T10093	mark	that,is
R5853	T10093	T10085	ccomp	is,suggest
R5854	T10094	T10093	nsubj	MTF,is
R5855	T10095	T10094	punct	-,MTF
R5856	T10096	T10094	nummod	1,MTF
R5857	T10097	T10093	acomp	important,is
R5858	T10098	T10097	prep	for,important
R5859	T10099	T10100	det	the,expression
R5860	T10100	T10098	pobj	expression,for
R5861	T10101	T10100	amod	basal,expression
R5862	T10102	T10100	prep	of,expression
R5863	T10103	T10104	compound	mouse,Sepw1
R5864	T10104	T10102	pobj	Sepw1,of
R5865	T10105	T10097	prep	by,important
R5866	T10106	T10105	pcomp	binding,by
R5867	T10107	T10106	prep	to,binding
R5868	T10108	T10109	det	the,sequence
R5869	T10109	T10107	pobj	sequence,to
R5870	T10110	T10109	amod	corresponding,sequence
R5871	T10111	T10112	amod	overlapping,inverted
R5872	T10112	T10109	amod	inverted,sequence
R5873	T10113	T10112	punct	-,inverted
R5874	T10114	T10109	compound	MRE,sequence
R5875	T10115	T10085	punct	.,suggest
R5876	T10117	T10118	nsubjpass	Ndrg1,named
R5877	T10119	T10117	punct	", ",Ndrg1
R5878	T10120	T10121	det	another,gene
R5879	T10121	T10117	appos	gene,Ndrg1
R5880	T10122	T10121	amod	interesting,gene
R5881	T10123	T10121	nmod	MTF,gene
R5882	T10124	T10123	punct	-,MTF
R5883	T10125	T10123	nummod	1,MTF
R5884	T10126	T10121	compound	target,gene
R5885	T10127	T10118	auxpass	was,named
R5886	T10128	T10129	nmod	N,myc
R5887	T10129	T10131	nmod	myc,gene
R5888	T10130	T10129	punct	-,myc
R5889	T10131	T10118	oprd	gene,named
R5890	T10132	T10133	advmod	downstream,regulated
R5891	T10133	T10131	amod	regulated,gene
R5892	T10134	T10131	nummod	1,gene
R5893	T10135	T10118	advcl	following,named
R5894	T10136	T10137	det	the,discovery
R5895	T10137	T10135	dobj	discovery,following
R5896	T10138	T10139	mark	that,represses
R5897	T10139	T10137	acl	represses,discovery
R5898	T10140	T10141	det	the,factor
R5899	T10141	T10139	nsubj	factor,represses
R5900	T10142	T10141	compound	transcription,factor
R5901	T10143	T10144	compound	N,myc
R5902	T10144	T10141	appos	myc,factor
R5903	T10145	T10144	punct	-,myc
R5904	T10146	T10147	det	the,expression
R5905	T10147	T10139	dobj	expression,represses
R5906	T10148	T10147	prep	of,expression
R5907	T10149	T10150	compound	mouse,Ndrg1
R5908	T10150	T10148	pobj	Ndrg1,of
R5909	T10151	T10152	punct	(,51
R5910	T10152	T10118	parataxis	51,named
R5911	T10153	T10152	punct	),51
R5912	T10154	T10118	punct	.,named
R5913	T10156	T10157	nsubjpass	Transcription,induced
R5914	T10158	T10156	prep	of,Transcription
R5915	T10159	T10158	pobj	Ndrg1,of
R5916	T10160	T10159	cc	and,Ndrg1
R5917	T10161	T10160	punct	/,and
R5918	T10162	T10160	cc	or,and
R5919	T10163	T10164	poss	its,ortholog
R5920	T10164	T10159	conj	ortholog,Ndrg1
R5921	T10165	T10164	amod	human,ortholog
R5922	T10166	T10157	auxpass	is,induced
R5923	T10167	T10157	agent	by,induced
R5924	T10168	T10169	amod	different,conditions
R5925	T10169	T10167	pobj	conditions,by
R5926	T10170	T10169	amod	physiological,conditions
R5927	T10171	T10170	cc	and,physiological
R5928	T10172	T10173	compound	cell,stress
R5929	T10173	T10170	conj	stress,physiological
R5930	T10174	T10169	punct	", ",conditions
R5931	T10175	T10176	amod	such,as
R5932	T10176	T10169	prep	as,conditions
R5933	T10177	T10176	pobj	androgens,as
R5934	T10178	T10177	punct	", ",androgens
R5935	T10179	T10180	compound	nickel,compounds
R5936	T10180	T10177	conj	compounds,androgens
R5937	T10181	T10180	punct	", ",compounds
R5938	T10182	T10180	conj	DNA,compounds
R5939	T10183	T10182	nmod	damage,DNA
R5940	T10184	T10182	cc	and,DNA
R5941	T10185	T10182	conj	hypoxia,DNA
R5942	T10186	T10187	punct	(,53
R5943	T10187	T10185	parataxis	53,hypoxia
R5944	T10188	T10187	dep	37,53
R5945	T10189	T10190	punct	–,40
R5946	T10190	T10188	prep	40,37
R5947	T10191	T10187	punct	",",53
R5948	T10192	T10187	dep	52,53
R5949	T10193	T10187	punct	",",53
R5950	T10194	T10187	punct	),53
R5951	T10195	T10157	punct	.,induced
R5952	T10197	T10198	prep	In,overexpressed
R5953	T10199	T10197	pobj	addition,In
R5954	T10200	T10198	punct	", ",overexpressed
R5955	T10201	T10202	det	the,protein
R5956	T10202	T10198	nsubjpass	protein,overexpressed
R5957	T10203	T10198	auxpass	is,overexpressed
R5958	T10204	T10198	prep	in,overexpressed
R5959	T10205	T10206	amod	human,cancers
R5960	T10206	T10204	pobj	cancers,in
R5961	T10207	T10206	prep	of,cancers
R5962	T10208	T10209	amod	many,tissues
R5963	T10209	T10207	pobj	tissues,of
R5964	T10210	T10209	punct	", ",tissues
R5965	T10211	T10212	amod	such,as
R5966	T10212	T10209	prep	as,tissues
R5967	T10213	T10212	pobj	lung,as
R5968	T10214	T10213	punct	", ",lung
R5969	T10215	T10213	conj	liver,lung
R5970	T10216	T10215	punct	", ",liver
R5971	T10217	T10215	conj	brain,liver
R5972	T10218	T10217	punct	", ",brain
R5973	T10219	T10217	conj	breast,brain
R5974	T10220	T10219	punct	", ",breast
R5975	T10221	T10219	conj	kidney,breast
R5976	T10222	T10221	cc	and,kidney
R5977	T10223	T10221	conj	skin,kidney
R5978	T10224	T10225	punct	(,40
R5979	T10225	T10198	parataxis	40,overexpressed
R5980	T10226	T10225	punct	),40
R5981	T10227	T10198	punct	.,overexpressed
R5982	T10229	T10230	mark	Although,studied
R5983	T10230	T10241	advcl	studied,remains
R5984	T10231	T10230	nsubjpass	Ndrg1,studied
R5985	T10232	T10231	cc	and,Ndrg1
R5986	T10233	T10234	advmod	especially,ortholog
R5987	T10234	T10231	conj	ortholog,Ndrg1
R5988	T10235	T10234	poss	its,ortholog
R5989	T10236	T10234	amod	human,ortholog
R5990	T10237	T10230	aux	have,studied
R5991	T10238	T10230	auxpass	been,studied
R5992	T10239	T10240	advmod	quite,intensely
R5993	T10240	T10230	advmod	intensely,studied
R5994	T10241	T10245	ccomp	remains,suggests
R5995	T10242	T10241	punct	", ",remains
R5996	T10243	T10244	poss	its,function
R5997	T10244	T10241	nsubj	function,remains
R5998	T10246	T10241	acomp	unclear,remains
R5999	T10247	T10245	punct	;,suggests
R6000	T10248	T10245	advmod	however,suggests
R6001	T10249	T10245	punct	", ",suggests
R6002	T10250	T10251	det	the,induction
R6003	T10251	T10245	nsubj	induction,suggests
R6004	T10252	T10251	prep	by,induction
R6005	T10253	T10252	pobj	stimuli,by
R6006	T10254	T10253	prep	like,stimuli
R6007	T10255	T10254	pobj	nickel,like
R6008	T10256	T10255	cc	and,nickel
R6009	T10257	T10255	conj	hypoxia,nickel
R6010	T10258	T10259	det	an,involvement
R6011	T10259	T10245	dobj	involvement,suggests
R6012	T10260	T10259	prep	in,involvement
R6013	T10261	T10262	det	the,response
R6014	T10262	T10260	pobj	response,in
R6015	T10263	T10262	compound	cell,response
R6016	T10264	T10262	compound	stress,response
R6017	T10265	T10245	punct	.,suggests
R6018	T10267	T10268	predet	Such,role
R6019	T10268	T10270	nsubjpass	role,endorsed
R6020	T10269	T10268	det	a,role
R6021	T10271	T10270	auxpass	is,endorsed
R6022	T10272	T10270	advmod	strongly,endorsed
R6023	T10273	T10270	agent	by,endorsed
R6024	T10274	T10275	poss	our,finding
R6025	T10275	T10273	pobj	finding,by
R6026	T10276	T10277	mark	that,induced
R6027	T10277	T10275	advcl	induced,finding
R6028	T10278	T10279	compound	Ndrg1,expression
R6029	T10279	T10277	nsubjpass	expression,induced
R6030	T10280	T10279	compound	gene,expression
R6031	T10281	T10277	auxpass	is,induced
R6032	T10282	T10277	advmod	also,induced
R6033	T10283	T10277	agent	by,induced
R6034	T10284	T10283	pobj	cadmium,by
R6035	T10285	T10277	punct	", ",induced
R6036	T10286	T10277	cc	and,induced
R6037	T10287	T10288	mark	that,plays
R6038	T10288	T10277	conj	plays,induced
R6039	T10289	T10288	nsubj	MTF,plays
R6040	T10290	T10289	punct	-,MTF
R6041	T10291	T10289	nummod	1,MTF
R6042	T10292	T10293	det	a,role
R6043	T10293	T10288	dobj	role,plays
R6044	T10294	T10293	amod	crucial,role
R6045	T10295	T10288	prep	in,plays
R6046	T10296	T10297	det	this,induction
R6047	T10297	T10295	pobj	induction,in
R6048	T10298	T10270	punct	.,endorsed
R6049	T10300	T10301	prep	In,indicate
R6050	T10302	T10303	det	the,case
R6051	T10303	T10300	pobj	case,In
R6052	T10304	T10303	prep	of,case
R6053	T10305	T10304	pobj	Csrp1,of
R6054	T10306	T10301	punct	", ",indicate
R6055	T10307	T10308	nmod	expression,analyses
R6056	T10308	T10309	nmod	analyses,studies
R6057	T10309	T10301	nsubj	studies,indicate
R6058	T10310	T10308	cc	and,analyses
R6059	T10311	T10308	conj	DNA,analyses
R6060	T10312	T10311	punct	-,DNA
R6061	T10313	T10311	amod	binding,DNA
R6062	T10314	T10315	mark	that,required
R6063	T10315	T10301	ccomp	required,indicate
R6064	T10316	T10315	nsubjpass	MTF,required
R6065	T10317	T10316	punct	-,MTF
R6066	T10318	T10316	nummod	1,MTF
R6067	T10319	T10315	auxpass	is,required
R6068	T10320	T10315	prep	for,required
R6069	T10321	T10322	compound	cadmium,induction
R6070	T10322	T10320	pobj	induction,for
R6071	T10323	T10315	prep	by,required
R6072	T10324	T10323	pcomp	binding,by
R6073	T10325	T10324	prep	to,binding
R6074	T10326	T10327	det	an,MRE
R6075	T10327	T10325	pobj	MRE,to
R6076	T10328	T10327	advmod	upstream,MRE
R6077	T10329	T10328	prep	of,upstream
R6078	T10330	T10331	det	the,start
R6079	T10331	T10329	pobj	start,of
R6080	T10332	T10331	compound	transcription,start
R6081	T10333	T10301	punct	.,indicate
R6082	T10335	T10336	nsubj	Studies,shown
R6083	T10337	T10335	prep	with,Studies
R6084	T10338	T10339	amod	human,CSRP1
R6085	T10339	T10337	pobj	CSRP1,with
R6086	T10340	T10338	punct	", ",human
R6087	T10341	T10338	conj	avian,human
R6088	T10342	T10341	cc	and,avian
R6089	T10343	T10341	conj	chicken,avian
R6090	T10344	T10336	aux	have,shown
R6091	T10345	T10346	mark	that,localized
R6092	T10346	T10336	ccomp	localized,shown
R6093	T10347	T10348	det	this,protein
R6094	T10348	T10346	nsubjpass	protein,localized
R6095	T10349	T10346	auxpass	is,localized
R6096	T10350	T10346	prep	at,localized
R6097	T10351	T10352	compound	adhesion,plaques
R6098	T10352	T10350	pobj	plaques,at
R6099	T10353	T10350	cc	and,at
R6100	T10354	T10350	conj	in,at
R6101	T10355	T10354	pobj	association,in
R6102	T10356	T10355	prep	with,association
R6103	T10357	T10358	amod	filamentous,actin
R6104	T10358	T10356	pobj	actin,with
R6105	T10359	T10346	punct	", ",localized
R6106	T10360	T10346	cc	and,localized
R6107	T10361	T10346	conj	interacts,localized
R6108	T10362	T10361	prep	with,interacts
R6109	T10363	T10364	det	the,protein
R6110	T10364	T10362	pobj	protein,with
R6111	T10365	T10364	compound	adhesion,protein
R6112	T10366	T10364	compound	plaque,protein
R6113	T10367	T10364	appos	zyxin,protein
R6114	T10368	T10364	punct	", ",protein
R6115	T10369	T10370	advmod	as,as
R6116	T10370	T10364	cc	as,protein
R6117	T10371	T10370	advmod	well,as
R6118	T10372	T10373	det	the,protein
R6119	T10373	T10364	conj	protein,protein
R6120	T10374	T10375	npadvmod	actin,cross-linking
R6121	T10375	T10373	amod	cross-linking,protein
R6122	T10376	T10375	punct	-,cross-linking
R6123	T10377	T10378	compound	alpha,actinin
R6124	T10378	T10373	appos	actinin,protein
R6125	T10379	T10378	punct	-,actinin
R6126	T10380	T10381	punct	(,54
R6127	T10381	T10361	parataxis	54,interacts
R6128	T10382	T10383	punct	–,57
R6129	T10383	T10381	prep	57,54
R6130	T10384	T10381	punct	),54
R6131	T10385	T10336	punct	.,shown
R6132	T10387	T10388	det	The,ability
R6133	T10388	T10389	nsubj	ability,suggests
R6134	T10390	T10391	aux	to,bind
R6135	T10391	T10388	acl	bind,ability
R6136	T10392	T10393	det	these,partners
R6137	T10393	T10391	dobj	partners,bind
R6138	T10394	T10395	det	a,role
R6139	T10395	T10389	dobj	role,suggests
R6140	T10396	T10395	prep	in,role
R6141	T10397	T10398	amod	cytoskeletal,organization
R6142	T10398	T10396	pobj	organization,in
R6143	T10399	T10400	punct	(,58
R6144	T10400	T10389	parataxis	58,suggests
R6145	T10401	T10400	punct	),58
R6146	T10402	T10389	punct	.,suggests
R6147	T10404	T10405	nsubj	Exposure,causes
R6148	T10406	T10404	prep	of,Exposure
R6149	T10407	T10408	amod	cultured,cells
R6150	T10408	T10406	pobj	cells,of
R6151	T10409	T10404	prep	to,Exposure
R6152	T10410	T10409	pobj	cadmium,to
R6153	T10411	T10412	det	a,decrease
R6154	T10412	T10405	dobj	decrease,causes
R6155	T10413	T10412	prep	in,decrease
R6156	T10414	T10412	punct	", ",decrease
R6157	T10415	T10412	cc	and,decrease
R6158	T10416	T10412	conj	destruction,decrease
R6159	T10417	T10416	prep	of,destruction
R6160	T10418	T10416	punct	", ",destruction
R6161	T10419	T10420	amod	cellular,contact
R6162	T10420	T10421	compound	contact,proteins
R6163	T10421	T10416	conj	proteins,destruction
R6164	T10422	T10421	cc	and,proteins
R6165	T10423	T10424	det	the,cytoskeleton
R6166	T10424	T10421	conj	cytoskeleton,proteins
R6167	T10425	T10424	compound	actin,cytoskeleton
R6168	T10426	T10427	punct	(,59
R6169	T10427	T10405	parataxis	59,causes
R6170	T10428	T10427	punct	),59
R6171	T10429	T10405	punct	.,causes
R6172	T10431	T10432	prep	In,observed
R6173	T10433	T10434	det	the,cells
R6174	T10434	T10431	pobj	cells,In
R6175	T10435	T10434	amod	proximal,cells
R6176	T10436	T10434	compound	tubule,cells
R6177	T10437	T10434	prep	of,cells
R6178	T10438	T10439	det	the,kidney
R6179	T10439	T10437	pobj	kidney,of
R6180	T10440	T10439	compound	rat,kidney
R6181	T10441	T10432	punct	", ",observed
R6182	T10442	T10443	det	a,loss
R6183	T10443	T10432	nsubjpass	loss,observed
R6184	T10444	T10443	amod	partial,loss
R6185	T10445	T10443	prep	of,loss
R6186	T10446	T10445	pobj	actin,of
R6187	T10447	T10446	cc	and,actin
R6188	T10448	T10449	det	the,protein
R6189	T10449	T10446	conj	protein,actin
R6190	T10450	T10451	npadvmod	actin,bundling
R6191	T10451	T10449	amod	bundling,protein
R6192	T10452	T10451	punct	-,bundling
R6193	T10453	T10449	appos	villin,protein
R6194	T10454	T10432	auxpass	is,observed
R6195	T10455	T10432	prep	upon,observed
R6196	T10456	T10457	compound	cadmium,treatment
R6197	T10457	T10455	pobj	treatment,upon
R6198	T10458	T10457	punct	", ",treatment
R6199	T10459	T10460	advmod	as,as
R6200	T10460	T10457	cc	as,treatment
R6201	T10461	T10460	advmod	well,as
R6202	T10462	T10463	det	the,derangement
R6203	T10463	T10457	conj	derangement,treatment
R6204	T10464	T10463	cc	and,derangement
R6205	T10465	T10463	conj	depolymerization,derangement
R6206	T10466	T10463	prep	of,derangement
R6207	T10467	T10466	pobj	microtubules,of
R6208	T10468	T10469	punct	(,60
R6209	T10469	T10432	parataxis	60,observed
R6210	T10470	T10469	punct	),60
R6211	T10471	T10432	punct	.,observed
R6212	T10473	T10474	advcl	Assuming,protect
R6213	T10475	T10476	mark	that,is
R6214	T10476	T10473	ccomp	is,Assuming
R6215	T10477	T10476	nsubj	CSRP1,is
R6216	T10478	T10476	acomp	important,is
R6217	T10479	T10478	prep	for,important
R6218	T10480	T10481	det	the,organization
R6219	T10481	T10479	pobj	organization,for
R6220	T10482	T10478	prep	of,important
R6221	T10483	T10484	amod	cytoskeletal,elements
R6222	T10484	T10482	pobj	elements,of
R6223	T10485	T10478	prep	in,important
R6224	T10486	T10487	det	the,mouse
R6225	T10487	T10485	pobj	mouse,in
R6226	T10488	T10474	punct	", ",protect
R6227	T10489	T10490	poss	its,upregulation
R6228	T10490	T10474	nsubj	upregulation,protect
R6229	T10491	T10490	prep	by,upregulation
R6230	T10492	T10491	pobj	cadmium,by
R6231	T10493	T10474	aux	might,protect
R6232	T10494	T10495	det	the,organism
R6233	T10495	T10474	dobj	organism,protect
R6234	T10496	T10474	prep	from,protect
R6235	T10497	T10496	pobj	damage,from
R6236	T10498	T10497	prep	of,damage
R6237	T10499	T10500	det	the,cytoskeleton
R6238	T10500	T10498	pobj	cytoskeleton,of
R6239	T10501	T10474	punct	.,protect
R6240	T10503	T10504	predet	Such,mechanism
R6241	T10504	T10506	nsubj	mechanism,expand
R6242	T10505	T10504	det	a,mechanism
R6243	T10507	T10506	aux	would,expand
R6244	T10508	T10509	det	the,role
R6245	T10509	T10506	dobj	role,expand
R6246	T10510	T10509	prep	of,role
R6247	T10511	T10510	pobj	MTF,of
R6248	T10512	T10511	punct	-,MTF
R6249	T10513	T10511	nummod	1,MTF
R6250	T10514	T10509	prep	in,role
R6251	T10515	T10516	compound	stress,response
R6252	T10516	T10514	pobj	response,in
R6253	T10517	T10506	punct	.,expand
R6254	T10519	T10520	poss	Our,studies
R6255	T10520	T10522	nsubj	studies,suggest
R6256	T10521	T10520	compound	expression,studies
R6257	T10523	T10522	advmod	also,suggest
R6258	T10524	T10525	mark	that,represses
R6259	T10525	T10522	ccomp	represses,suggest
R6260	T10526	T10525	nsubj	MTF,represses
R6261	T10527	T10526	punct	-,MTF
R6262	T10528	T10526	nummod	1,MTF
R6263	T10529	T10530	amod	basal,transcription
R6264	T10530	T10525	dobj	transcription,represses
R6265	T10531	T10530	prep	of,transcription
R6266	T10532	T10531	pobj	Slc39a10,of
R6267	T10533	T10525	punct	", ",represses
R6268	T10534	T10525	prep	in,represses
R6269	T10535	T10534	pobj	contrast,in
R6270	T10536	T10535	prep	to,contrast
R6271	T10537	T10538	poss	its,role
R6272	T10538	T10536	pobj	role,to
R6273	T10539	T10538	prep	as,role
R6274	T10540	T10539	pobj	activator,as
R6275	T10541	T10540	prep	for,activator
R6276	T10542	T10543	det	the,expression
R6277	T10543	T10541	pobj	expression,for
R6278	T10544	T10543	prep	of,expression
R6279	T10545	T10546	amod	other,genes
R6280	T10546	T10544	pobj	genes,of
R6281	T10547	T10546	compound	target,genes
R6282	T10548	T10546	prep	like,genes
R6283	T10549	T10548	pobj	Mt1,like
R6284	T10550	T10549	punct	", ",Mt1
R6285	T10551	T10549	conj	Mt2,Mt1
R6286	T10552	T10551	punct	", ",Mt2
R6287	T10553	T10551	cc	and,Mt2
R6288	T10554	T10551	conj	Znt1,Mt2
R6289	T10555	T10556	punct	(,19
R6290	T10556	T10525	parataxis	19,represses
R6291	T10557	T10556	nummod	4,19
R6292	T10558	T10556	punct	",",19
R6293	T10559	T10556	punct	),19
R6294	T10560	T10522	punct	.,suggest
R6295	T10562	T10563	nsubj	SLC39A10,is
R6296	T10564	T10563	attr	one,is
R6297	T10565	T10564	prep	of,one
R6298	T10566	T10567	nummod	14,members
R6299	T10567	T10565	pobj	members,of
R6300	T10568	T10567	compound	mouse,members
R6301	T10569	T10567	compound	SLC39,members
R6302	T10570	T10567	punct	", ",members
R6303	T10571	T10572	dep	which,belong
R6304	T10572	T10567	relcl	belong,members
R6305	T10573	T10572	prep	to,belong
R6306	T10574	T10575	det	the,family
R6307	T10575	T10573	pobj	family,to
R6308	T10576	T10575	compound	ZIP,family
R6309	T10577	T10575	prep	of,family
R6310	T10578	T10579	compound	metal,ion
R6311	T10579	T10580	compound	ion,transporters
R6312	T10580	T10577	pobj	transporters,of
R6313	T10581	T10582	punct	(,44
R6314	T10582	T10572	parataxis	44,belong
R6315	T10583	T10582	nummod	43,44
R6316	T10584	T10582	punct	",",44
R6317	T10585	T10582	punct	),44
R6318	T10586	T10563	punct	.,is
R6319	T10588	T10589	det	All,members
R6320	T10589	T10590	nsubj	members,increase
R6321	T10591	T10589	prep	of,members
R6322	T10592	T10593	det	the,family
R6323	T10593	T10591	pobj	family,of
R6324	T10594	T10593	compound	ZIP,family
R6325	T10595	T10589	acl	characterized,members
R6326	T10596	T10597	advmod	so,far
R6327	T10597	T10595	advmod	far,characterized
R6328	T10598	T10599	amod	intracellular,concentrations
R6329	T10599	T10590	dobj	concentrations,increase
R6330	T10600	T10599	amod	cytoplasmic,concentrations
R6331	T10601	T10602	compound	metal,ion
R6332	T10602	T10599	compound	ion,concentrations
R6333	T10603	T10590	prep	by,increase
R6334	T10604	T10603	pcomp	promoting,by
R6335	T10605	T10606	amod	extracellular,transport
R6336	T10606	T10604	dobj	transport,promoting
R6337	T10607	T10605	cc	and,extracellular
R6338	T10608	T10605	conj	vesicular,extracellular
R6339	T10609	T10606	compound	ion,transport
R6340	T10610	T10606	prep	into,transport
R6341	T10611	T10612	det	the,cytoplasm
R6342	T10612	T10610	pobj	cytoplasm,into
R6343	T10613	T10590	punct	.,increase
R6344	T10615	T10616	compound	ZIP,proteins
R6345	T10616	T10617	nsubjpass	proteins,reported
R6346	T10618	T10617	aux	have,reported
R6347	T10619	T10617	auxpass	been,reported
R6348	T10620	T10621	aux	to,be
R6349	T10621	T10617	xcomp	be,reported
R6350	T10622	T10621	attr	transporters,be
R6351	T10623	T10622	prep	of,transporters
R6352	T10624	T10623	pobj	zinc,of
R6353	T10625	T10624	punct	", ",zinc
R6354	T10626	T10624	conj	iron,zinc
R6355	T10627	T10626	punct	", ",iron
R6356	T10628	T10626	conj	manganese,iron
R6357	T10629	T10628	cc	and,manganese
R6358	T10630	T10629	punct	/,and
R6359	T10631	T10629	cc	or,and
R6360	T10632	T10628	conj	cadmium,manganese
R6361	T10633	T10634	punct	(,44
R6362	T10634	T10621	parataxis	44,be
R6363	T10635	T10634	punct	",",44
R6364	T10636	T10634	appos	61,44
R6365	T10637	T10638	punct	–,63
R6366	T10638	T10636	prep	63,61
R6367	T10639	T10634	punct	),44
R6368	T10640	T10617	punct	.,reported
R6369	T10642	T10643	mark	Although,is
R6370	T10643	T10645	advcl	is,referred
R6371	T10644	T10643	nsubj	SLC39A10,is
R6372	T10646	T10647	advmod	largely,uncharacterized
R6373	T10647	T10643	acomp	uncharacterized,is
R6374	T10648	T10649	punct	(,44
R6375	T10649	T10643	parataxis	44,is
R6376	T10650	T10649	punct	),44
R6377	T10651	T10645	punct	", ",referred
R6378	T10652	T10645	nsubjpass	it,referred
R6379	T10653	T10645	auxpass	is,referred
R6380	T10654	T10645	prep	to,referred
R6381	T10655	T10645	prep	in,referred
R6382	T10656	T10657	amod	several,databases
R6383	T10657	T10655	pobj	databases,in
R6384	T10658	T10645	prep	as,referred
R6385	T10659	T10660	amod	putative,transporter
R6386	T10660	T10658	pobj	transporter,as
R6387	T10661	T10660	compound	zinc,transporter
R6388	T10662	T10645	punct	.,referred
R6389	T10664	T10665	nsubjpass	It,shown
R6390	T10666	T10665	aux	has,shown
R6391	T10667	T10665	auxpass	been,shown
R6392	T10668	T10665	advmod	previously,shown
R6393	T10669	T10670	mark	that,is
R6394	T10670	T10665	ccomp	is,shown
R6395	T10671	T10670	nsubj	MTF,is
R6396	T10672	T10671	punct	-,MTF
R6397	T10673	T10671	nummod	1,MTF
R6398	T10674	T10670	acomp	important,is
R6399	T10675	T10674	prep	for,important
R6400	T10676	T10677	preconj	both,expression
R6401	T10677	T10675	pobj	expression,for
R6402	T10678	T10677	amod	basal,expression
R6403	T10679	T10677	cc	and,expression
R6404	T10680	T10681	compound	metal,induction
R6405	T10681	T10677	conj	induction,expression
R6406	T10682	T10677	prep	of,expression
R6407	T10683	T10684	det	the,gene
R6408	T10684	T10682	pobj	gene,of
R6409	T10685	T10684	compound	mouse,gene
R6410	T10686	T10684	compound	Znt1,gene
R6411	T10687	T10688	punct	(,19
R6412	T10688	T10670	parataxis	19,is
R6413	T10689	T10688	punct	),19
R6414	T10690	T10665	punct	.,shown
R6415	T10692	T10693	compound	ZnT,proteins
R6416	T10693	T10694	nsubj	proteins,represent
R6417	T10695	T10696	det	a,family
R6418	T10696	T10694	dobj	family,represent
R6419	T10697	T10696	amod	different,family
R6420	T10698	T10696	prep	of,family
R6421	T10699	T10698	pobj	transporters,of
R6422	T10700	T10701	dep	that,reduce
R6423	T10701	T10696	relcl	reduce,family
R6424	T10702	T10703	amod	intracellular,zinc
R6425	T10703	T10701	dobj	zinc,reduce
R6426	T10704	T10703	amod	cytoplasmic,zinc
R6427	T10705	T10701	prep	by,reduce
R6428	T10706	T10705	pcomp	promoting,by
R6429	T10707	T10708	compound	zinc,efflux
R6430	T10708	T10706	dobj	efflux,promoting
R6431	T10709	T10708	prep	from,efflux
R6432	T10710	T10709	pobj	cells,from
R6433	T10711	T10709	cc	or,from
R6434	T10712	T10709	conj	into,from
R6435	T10713	T10714	amod	intracellular,vesicles
R6436	T10714	T10712	pobj	vesicles,into
R6437	T10715	T10694	punct	.,represent
R6438	T10717	T10718	advmod	Thus,have
R6439	T10719	T10718	punct	", ",have
R6440	T10720	T10718	nsubj	members,have
R6441	T10721	T10720	prep	of,members
R6442	T10722	T10723	det	the,family
R6443	T10723	T10721	pobj	family,of
R6444	T10724	T10723	nmod	ZnT,family
R6445	T10725	T10724	cc	and,ZnT
R6446	T10726	T10724	conj	ZIP,ZnT
R6447	T10727	T10720	prep	with,members
R6448	T10728	T10727	pobj	zinc,with
R6449	T10729	T10728	prep	as,zinc
R6450	T10730	T10731	amod	predominant,substrate
R6451	T10731	T10729	pobj	substrate,as
R6452	T10732	T10733	amod	opposite,roles
R6453	T10733	T10718	dobj	roles,have
R6454	T10734	T10733	prep	in,roles
R6455	T10735	T10736	amod	cellular,homeostasis
R6456	T10736	T10734	pobj	homeostasis,in
R6457	T10737	T10736	compound	zinc,homeostasis
R6458	T10738	T10739	punct	(,43
R6459	T10739	T10718	parataxis	43,have
R6460	T10740	T10739	punct	),43
R6461	T10741	T10718	punct	.,have
R6462	T10743	T10744	advcl	Assuming,control
R6463	T10745	T10746	mark	that,is
R6464	T10746	T10743	ccomp	is,Assuming
R6465	T10747	T10746	nsubj	SLC39A10,is
R6466	T10748	T10746	advmod	indeed,is
R6467	T10749	T10750	det	a,transporter
R6468	T10750	T10746	attr	transporter,is
R6469	T10751	T10750	compound	zinc,transporter
R6470	T10752	T10744	punct	", ",control
R6471	T10753	T10744	nsubj	MTF,control
R6472	T10754	T10753	punct	-,MTF
R6473	T10755	T10753	nummod	1,MTF
R6474	T10756	T10744	aux	would,control
R6475	T10757	T10744	dobj	expression,control
R6476	T10758	T10757	prep	of,expression
R6477	T10759	T10760	nummod	two,transporters
R6478	T10760	T10758	pobj	transporters,of
R6479	T10761	T10760	compound	zinc,transporters
R6480	T10762	T10760	prep	with,transporters
R6481	T10763	T10764	amod	antagonistic,functions
R6482	T10764	T10762	pobj	functions,with
R6483	T10765	T10760	punct	", ",transporters
R6484	T10766	T10767	advmod	namely,Znt1
R6485	T10767	T10760	appos	Znt1,transporters
R6486	T10768	T10767	punct	", ",Znt1
R6487	T10769	T10767	cc	and,Znt1
R6488	T10770	T10767	conj	Slc39a10,Znt1
R6489	T10771	T10744	punct	.,control
R6490	T10773	T10774	amod	Specific,binding
R6491	T10774	T10775	nsubjpass	binding,observed
R6492	T10776	T10774	prep	of,binding
R6493	T10777	T10776	pobj	MTF,of
R6494	T10778	T10777	punct	-,MTF
R6495	T10779	T10777	nummod	1,MTF
R6496	T10780	T10775	auxpass	was,observed
R6497	T10781	T10775	prep	for,observed
R6498	T10782	T10783	det	an,MRE
R6499	T10783	T10781	pobj	MRE,for
R6500	T10784	T10783	acl	located,MRE
R6501	T10785	T10786	advmod	just,downstream
R6502	T10786	T10784	advmod	downstream,located
R6503	T10787	T10786	prep	of,downstream
R6504	T10788	T10789	det	the,start
R6505	T10789	T10787	pobj	start,of
R6506	T10790	T10789	compound	Slc39a10,start
R6507	T10791	T10789	compound	transcription,start
R6508	T10792	T10775	punct	.,observed
R6509	T10794	T10795	prep	In,interfere
R6510	T10796	T10797	det	a,model
R6511	T10797	T10794	pobj	model,In
R6512	T10798	T10797	amod	simple,model
R6513	T10799	T10795	punct	", ",interfere
R6514	T10800	T10801	predet	such,binding
R6515	T10801	T10795	nsubj	binding,interfere
R6516	T10802	T10801	det	a,binding
R6517	T10803	T10795	aux	could,interfere
R6518	T10804	T10795	prep	with,interfere
R6519	T10805	T10806	det	the,accessibility
R6520	T10806	T10804	pobj	accessibility,with
R6521	T10807	T10806	prep	of,accessibility
R6522	T10808	T10809	det	the,site
R6523	T10809	T10807	pobj	site,of
R6524	T10810	T10809	amod	transcriptional,site
R6525	T10811	T10809	compound	start,site
R6526	T10812	T10809	prep	for,site
R6527	T10813	T10814	compound	RNA,polymerase
R6528	T10814	T10812	pobj	polymerase,for
R6529	T10815	T10814	nummod	II,polymerase
R6530	T10816	T10814	cc	and,polymerase
R6531	T10817	T10816	punct	/,and
R6532	T10818	T10816	cc	or,and
R6533	T10819	T10820	amod	general,factors
R6534	T10820	T10814	conj	factors,polymerase
R6535	T10821	T10820	compound	transcription,factors
R6536	T10822	T10795	punct	", ",interfere
R6537	T10823	T10824	advmod	thus,preventing
R6538	T10824	T10795	advcl	preventing,interfere
R6539	T10825	T10826	compound	transcription,initiation
R6540	T10826	T10824	dobj	initiation,preventing
R6541	T10827	T10826	prep	of,initiation
R6542	T10828	T10829	det	the,gene
R6543	T10829	T10827	pobj	gene,of
R6544	T10830	T10795	punct	.,interfere
R6545	T10832	T10833	advmod	Indeed,described
R6546	T10834	T10833	punct	", ",described
R6547	T10835	T10836	predet	such,mechanism
R6548	T10836	T10833	nsubjpass	mechanism,described
R6549	T10837	T10836	det	a,mechanism
R6550	T10838	T10833	aux	has,described
R6551	T10839	T10833	auxpass	been,described
R6552	T10840	T10833	prep	in,described
R6553	T10841	T10840	pobj	yeast,in
R6554	T10842	T10833	prep	for,described
R6555	T10843	T10844	det	the,protein
R6556	T10844	T10842	pobj	protein,for
R6557	T10845	T10846	npadvmod	zinc,responsive
R6558	T10846	T10844	amod	responsive,protein
R6559	T10847	T10846	punct	-,responsive
R6560	T10848	T10844	compound	activator,protein
R6561	T10849	T10844	nummod	1,protein
R6562	T10850	T10844	punct	(,protein
R6563	T10851	T10844	appos	Zap1,protein
R6564	T10852	T10844	punct	),protein
R6565	T10853	T10844	cc	and,protein
R6566	T10854	T10855	poss	its,gene
R6567	T10855	T10844	conj	gene,protein
R6568	T10856	T10855	compound	target,gene
R6569	T10857	T10855	punct	", ",gene
R6570	T10858	T10859	nmod	zinc,transporter
R6571	T10859	T10855	appos	transporter,gene
R6572	T10860	T10859	punct	-,transporter
R6573	T10861	T10859	amod	regulated,transporter
R6574	T10862	T10859	nummod	2,transporter
R6575	T10863	T10859	punct	(,transporter
R6576	T10864	T10859	appos	ZRT2,transporter
R6577	T10865	T10833	punct	),described
R6578	T10866	T10867	punct	(,64
R6579	T10867	T10833	parataxis	64,described
R6580	T10868	T10867	punct	),64
R6581	T10869	T10833	punct	.,described
R6582	T10871	T10872	advmod	However,be
R6583	T10873	T10872	punct	", ",be
R6584	T10874	T10875	det	the,inhibition
R6585	T10875	T10872	nsubj	inhibition,be
R6586	T10876	T10875	prep	of,inhibition
R6587	T10877	T10878	compound	Slc39a10,expression
R6588	T10878	T10876	pobj	expression,of
R6589	T10879	T10875	prep	by,inhibition
R6590	T10880	T10879	pobj	MTF,by
R6591	T10881	T10880	punct	-,MTF
R6592	T10882	T10880	nummod	1,MTF
R6593	T10883	T10872	aux	may,be
R6594	T10884	T10872	advmod	well,be
R6595	T10885	T10886	advmod	more,complex
R6596	T10886	T10872	acomp	complex,be
R6597	T10887	T10886	prep	than,complex
R6598	T10888	T10889	det	a,competition
R6599	T10889	T10887	pobj	competition,than
R6600	T10890	T10889	prep	for,competition
R6601	T10891	T10892	compound	promoter,binding
R6602	T10892	T10890	pobj	binding,for
R6603	T10893	T10872	punct	.,be
R6604	T10895	T10896	advcl	Independent,leads
R6605	T10897	T10895	prep	of,Independent
R6606	T10898	T10897	pobj	MTF,of
R6607	T10899	T10898	punct	-,MTF
R6608	T10900	T10898	nummod	1,MTF
R6609	T10901	T10896	punct	", ",leads
R6610	T10902	T10903	compound	cadmium,treatment
R6611	T10903	T10896	nsubj	treatment,leads
R6612	T10904	T10896	advmod	also,leads
R6613	T10905	T10896	prep	to,leads
R6614	T10906	T10905	pobj	downregulation,to
R6615	T10907	T10906	prep	of,downregulation
R6616	T10908	T10909	compound	Slc39a10,transcripts
R6617	T10909	T10907	pobj	transcripts,of
R6618	T10910	T10896	punct	", ",leads
R6619	T10911	T10896	advcl	suggesting,leads
R6620	T10912	T10913	mark	that,mediating
R6621	T10913	T10911	ccomp	mediating,suggesting
R6622	T10914	T10915	det	some,factor
R6623	T10915	T10913	nsubj	factor,mediating
R6624	T10916	T10915	amod	other,factor
R6625	T10917	T10913	aux	is,mediating
R6626	T10918	T10919	det	this,response
R6627	T10919	T10913	dobj	response,mediating
R6628	T10920	T10896	punct	.,leads
R6629	T10922	T10923	det	A,search
R6630	T10923	T10927	nsubj	search,revealed
R6631	T10924	T10923	amod	previous,search
R6632	T10925	T10926	compound	target,gene
R6633	T10926	T10923	compound	gene,search
R6634	T10928	T10923	prep	for,search
R6635	T10929	T10928	pobj	MTF,for
R6636	T10930	T10929	punct	-,MTF
R6637	T10931	T10929	nummod	1,MTF
R6638	T10932	T10923	prep	with,search
R6639	T10933	T10934	compound	mouse,embryos
R6640	T10934	T10932	pobj	embryos,with
R6641	T10935	T10934	prep	of,embryos
R6642	T10936	T10937	amod	conventional,phenotype
R6643	T10937	T10935	pobj	phenotype,of
R6644	T10938	T10937	compound	Mtf1,phenotype
R6645	T10939	T10937	compound	knockout,phenotype
R6646	T10940	T10927	punct	", ",revealed
R6647	T10941	T10927	prep	besides,revealed
R6648	T10942	T10943	compound	metallothionein,genes
R6649	T10943	T10941	pobj	genes,besides
R6650	T10944	T10927	punct	", ",revealed
R6651	T10945	T10946	det	the,fetoprotein
R6652	T10946	T10927	dobj	fetoprotein,revealed
R6653	T10947	T10946	amod	multifunctional,fetoprotein
R6654	T10948	T10946	compound	alpha,fetoprotein
R6655	T10949	T10946	punct	-,fetoprotein
R6656	T10950	T10946	punct	(,fetoprotein
R6657	T10951	T10946	appos	Afp,fetoprotein
R6658	T10952	T10946	punct	),fetoprotein
R6659	T10953	T10946	cc	and,fetoprotein
R6660	T10954	T10955	det	the,factor
R6661	T10955	T10946	conj	factor,fetoprotein
R6662	T10956	T10957	npadvmod	liver,enriched
R6663	T10957	T10955	amod	enriched,factor
R6664	T10958	T10957	punct	-,enriched
R6665	T10959	T10955	compound	transcription,factor
R6666	T10960	T10961	compound	CCAAT,protein
R6667	T10961	T10955	appos	protein,factor
R6668	T10962	T10961	punct	/,protein
R6669	T10963	T10961	compound	enhancer,protein
R6670	T10964	T10961	compound	binding,protein
R6671	T10965	T10961	punct	alpha,protein
R6672	T10966	T10961	punct	(,protein
R6673	T10967	T10961	appos	Cebpa,protein
R6674	T10968	T10927	punct	),revealed
R6675	T11052	T11051	cc	and,Mtf1loxP
R6676	T10969	T10927	prep	as,revealed
R6677	T11053	T11054	compound	Mtf1Mx,cre
R6678	T10970	T10971	amod	prime,candidates
R6679	T11054	T11051	conj	cre,Mtf1loxP
R6680	T11055	T11054	punct	-,cre
R6681	T10971	T10969	pobj	candidates,as
R6682	T11056	T11057	punct	(,shown
R6683	T11057	T11041	parataxis	shown,revealed
R6684	T11058	T11057	nsubj	data,shown
R6685	T10972	T10973	punct	(,65
R6686	T11059	T11057	neg	not,shown
R6687	T11060	T11057	punct	),shown
R6688	T10973	T10927	parataxis	65,revealed
R6689	T11061	T11041	punct	.,revealed
R6690	T10974	T10973	punct	),65
R6691	T11063	T11064	advmod	Therefore,affect
R6692	T11065	T11064	punct	", ",affect
R6693	T10975	T10927	punct	.,revealed
R6694	T11066	T11064	nsubj	MTF,affect
R6695	T11067	T11066	punct	-,MTF
R6696	T11068	T11066	nummod	1,MTF
R6697	T10977	T10978	prep	After,repressed
R6698	T11069	T11064	aux	may,affect
R6699	T11070	T11071	compound	Cebpa,expression
R6700	T11071	T11064	dobj	expression,affect
R6701	T11072	T11073	advmod	only,during
R6702	T10979	T10980	det	an,onset
R6703	T11073	T11064	prep	during,affect
R6704	T11074	T11075	amod	embryonal,development
R6705	T11075	T11073	pobj	development,during
R6706	T11076	T11064	punct	", ",affect
R6707	T10980	T10977	pobj	onset,After
R6708	T11077	T11078	advmod	perhaps,in
R6709	T11078	T11064	prep	in,affect
R6710	T10981	T10980	amod	early,onset
R6711	T11079	T11078	pobj	combination,in
R6712	T11080	T11079	prep	with,combination
R6713	T11081	T11082	advmod	as,yet
R6714	T10982	T10978	prep	during,repressed
R6715	T10983	T10982	pobj	hepatogenesis,during
R6716	T10984	T10978	punct	", ",repressed
R6717	T11082	T11083	advmod	yet,unidentified
R6718	T11083	T11084	amod	unidentified,factors
R6719	T10985	T10986	compound	Afp,expression
R6720	T11084	T11080	pobj	factors,with
R6721	T11085	T11064	punct	.,affect
R6722	T10986	T10978	nsubjpass	expression,repressed
R6723	T11087	T11088	det	The,study
R6724	T11088	T11090	nsubj	study,confirms
R6725	T11089	T11088	amod	present,study
R6726	T10987	T10978	auxpass	is,repressed
R6727	T11091	T11090	cc	and,confirms
R6728	T11092	T11090	conj	extends,confirms
R6729	T10988	T10978	advmod	postnatally,repressed
R6730	T11093	T11094	det	the,role
R6731	T11094	T11092	dobj	role,extends
R6732	T11095	T11094	prep	of,role
R6733	T10989	T10978	cc	and,repressed
R6734	T11096	T11095	pobj	MTF,of
R6735	T11097	T11096	punct	-,MTF
R6736	T11098	T11096	nummod	1,MTF
R6737	T10990	T10978	conj	replaced,repressed
R6738	T11099	T11094	prep	as,role
R6739	T11100	T11101	det	an,regulator
R6740	T10991	T10990	agent	by,replaced
R6741	T11101	T11099	pobj	regulator,as
R6742	T11102	T11101	amod	important,regulator
R6743	T11103	T11104	compound	stress,response
R6744	T10992	T10991	pobj	albumin,by
R6745	T11104	T11101	compound	response,regulator
R6746	T11105	T11090	punct	.,confirms
R6747	T11107	T11108	nsubj	We,identified
R6748	T11108	T11110	ccomp	identified,required
R6749	T11109	T11108	aux	have,identified
R6750	T10993	T10994	punct	(,66
R6751	T11111	T11108	cc	and,identified
R6752	T11112	T11113	advmod	preliminarily,characterized
R6753	T10994	T10990	parataxis	66,replaced
R6754	T11113	T11108	conj	characterized,identified
R6755	T11114	T11115	nummod	four,genes
R6756	T11115	T11113	dobj	genes,characterized
R6757	T10995	T10994	punct	),66
R6758	T11116	T11115	compound	target,genes
R6759	T11117	T11115	prep	of,genes
R6760	T10996	T10978	punct	.,repressed
R6761	T11118	T11117	pobj	MTF,of
R6762	T11119	T11118	punct	-,MTF
R6763	T11120	T11118	nummod	1,MTF
R6764	T10998	T10999	advmod	Thus,were
R6765	T11121	T11115	prep	in,genes
R6766	T11122	T11123	det	the,liver
R6767	T11123	T11121	pobj	liver,in
R6768	T11124	T11123	amod	adult,liver
R6769	T11000	T10999	punct	", ",were
R6770	T11125	T11123	compound	mouse,liver
R6771	T11126	T11110	punct	: ,required
R6772	T11001	T11002	poss	our,mice
R6773	T11127	T11110	prep	in,required
R6774	T11128	T11129	det	the,case
R6775	T11129	T11127	pobj	case,in
R6776	T11130	T11129	prep	of,case
R6777	T11002	T10999	nsubj	mice,were
R6778	T11131	T11130	pobj	Sepw1,of
R6779	T11132	T11110	punct	", ",required
R6780	T11133	T11110	nsubjpass	MTF,required
R6781	T11003	T11002	amod	adult,mice
R6782	T11134	T11133	punct	-,MTF
R6783	T11135	T11133	nummod	1,MTF
R6784	T11004	T11005	compound	Mtf1Mx,cre
R6785	T11136	T11110	auxpass	is,required
R6786	T11137	T11138	aux	to,maintain
R6787	T11138	T11110	advcl	maintain,required
R6788	T11005	T11002	compound	cre,mice
R6789	T11139	T11140	amod	basal,expression
R6790	T11140	T11138	dobj	expression,maintain
R6791	T11141	T11110	punct	", ",required
R6792	T11006	T11005	punct	-,cre
R6793	T11142	T11110	advcl	supporting,required
R6794	T11143	T11144	det	a,role
R6795	T11144	T11142	dobj	role,supporting
R6796	T11007	T11002	acl	lacking,mice
R6797	T11145	T11144	prep	of,role
R6798	T11146	T11147	compound	mouse,MTF
R6799	T11147	T11145	pobj	MTF,of
R6800	T11148	T11147	punct	-,MTF
R6801	T11149	T11147	nummod	1,MTF
R6802	T11150	T11144	prep	in,role
R6803	T11008	T11007	dobj	MTF,lacking
R6804	T11151	T11152	amod	oxidative,response
R6805	T11009	T11008	punct	-,MTF
R6806	T11152	T11150	pobj	response,in
R6807	T11153	T11152	compound	stress,response
R6808	T11010	T11008	nummod	1,MTF
R6809	T11154	T11110	punct	.,required
R6810	T11156	T11157	prep	In,contributes
R6811	T11011	T10999	neg	not,were
R6812	T11012	T10999	acomp	suitable,were
R6813	T11013	T11014	aux	to,analyze
R6814	T11014	T10999	advcl	analyze,were
R6815	T11015	T11016	compound	Afp,expression
R6816	T11158	T11156	pobj	addition,In
R6817	T11159	T11157	punct	", ",contributes
R6818	T11160	T11157	nsubj	MTF,contributes
R6819	T11016	T11014	dobj	expression,analyze
R6820	T11161	T11160	punct	-,MTF
R6821	T11162	T11160	nummod	1,MTF
R6822	T11017	T10999	punct	.,were
R6823	T11163	T11157	prep	to,contributes
R6824	T11164	T11165	det	the,expression
R6826	T11019	T11020	nsubjpass	Cebpa,expressed
R6827	T11166	T11167	npadvmod	cadmium,induced
R6828	T11167	T11165	amod	induced,expression
R6829	T11168	T11167	punct	-,induced
R6830	T11021	T11020	auxpass	is,expressed
R6831	T11169	T11165	prep	of,expression
R6832	T11170	T11169	pobj	Ndrg1,of
R6833	T11171	T11170	cc	and,Ndrg1
R6834	T11172	T11170	conj	Csrp1,Ndrg1
R6835	T11022	T11020	prep	in,expressed
R6836	T11173	T11157	punct	.,contributes
R6837	T11175	T11176	advmod	Furthermore,helps
R6838	T11023	T11024	det	the,liver
R6839	T11177	T11176	punct	", ",helps
R6840	T11024	T11022	pobj	liver,in
R6841	T11178	T11176	nsubj	MTF,helps
R6842	T11179	T11178	punct	-,MTF
R6843	T11180	T11178	nummod	1,MTF
R6844	T11025	T11024	amod	adult,liver
R6845	T11181	T11182	aux	to,repress
R6846	T11182	T11176	xcomp	repress,helps
R6847	T11183	T11184	det	the,expression
R6848	T11026	T11027	advmod	as,as
R6849	T11184	T11182	dobj	expression,repress
R6850	T11185	T11184	amod	basal,expression
R6851	T11186	T11184	prep	of,expression
R6852	T11187	T11186	pobj	Slc39a10,of
R6853	T11188	T11182	punct	", ",repress
R6854	T11189	T11182	prep	in,repress
R6855	T11027	T11022	cc	as,in
R6856	T11190	T11189	pobj	contrast,in
R6857	T11191	T11190	prep	to,contrast
R6858	T11192	T11193	poss	its,role
R6859	T11193	T11191	pobj	role,to
R6860	T11028	T11027	advmod	well,as
R6861	T11194	T11193	prep	as,role
R6862	T11195	T11196	amod	transcriptional,activator
R6863	T11029	T11022	conj	in,in
R6864	T11196	T11194	pobj	activator,as
R6865	T11197	T11196	prep	for,activator
R6866	T11198	T11197	pobj	genes,for
R6867	T11030	T11031	amod	other,tissues
R6868	T11199	T11198	prep	like,genes
R6869	T11200	T11199	pobj	Mt1,like
R6870	T11201	T11200	punct	", ",Mt1
R6871	T11031	T11029	pobj	tissues,in
R6872	T11202	T11200	conj	Mt2,Mt1
R6873	T11203	T11202	cc	or,Mt2
R6874	T11204	T11202	conj	Znt1,Mt2
R6875	T11032	T11033	punct	(,67
R6876	T11205	T11176	punct	.,helps
R6877	T11033	T11020	parataxis	67,expressed
R6878	T11207	T11208	advmod	Thus,serves
R6879	T11209	T11210	det	the,factor
R6880	T11034	T11033	punct	),67
R6881	T11210	T11208	nsubj	factor,serves
R6882	T11211	T11210	amod	same,factor
R6883	T11035	T11020	punct	", ",expressed
R6884	T11212	T11210	compound	transcription,factor
R6885	T11213	T11208	advmod	apparently,serves
R6886	T11214	T11208	prep	as,serves
R6887	T11215	T11216	det	an,activator
R6888	T11036	T11020	cc	but,expressed
R6889	T11216	T11214	pobj	activator,as
R6890	T11217	T11216	cc	or,activator
R6891	T11218	T11216	conj	repressor,activator
R6892	T11037	T11038	det	the,data
R6893	T11219	T11208	punct	", ",serves
R6894	T11220	T11208	prep	depending,serves
R6895	T11221	T11220	prep	on,depending
R6896	T11038	T11041	nsubj	data,revealed
R6897	T11222	T11223	det	the,gene
R6898	T11223	T11221	pobj	gene,on
R6899	T11224	T11223	compound	target,gene
R6900	T11039	T11038	amod	present,data
R6901	T11225	T11208	punct	.,serves
R6902	T11040	T11038	compound	microarray,data
R6903	T11227	T11228	det	The,comparison
R6904	T11228	T11229	nsubj	comparison,revealed
R6905	T11230	T11228	prep	of,comparison
R6906	T11231	T11232	compound	liver,gene
R6907	T11232	T11233	compound	gene,expression
R6908	T11041	T11020	conj	revealed,expressed
R6909	T11233	T11230	pobj	expression,of
R6910	T11234	T11233	prep	of,expression
R6911	T11235	T11236	npadvmod	cadmium,treated
R6912	T11236	T11241	amod	treated,mice
R6913	T11042	T11043	det	no,differences
R6914	T11237	T11235	punct	-,cadmium
R6915	T11238	T11235	cc	and,cadmium
R6916	T11043	T11041	dobj	differences,revealed
R6917	T11239	T11235	conj	mock,cadmium
R6918	T11240	T11236	punct	-,treated
R6919	T11044	T11043	amod	significant,differences
R6920	T11045	T11043	compound	expression,differences
R6921	T11241	T11234	pobj	mice,of
R6922	T11046	T11041	prep	in,revealed
R6923	T11242	T11229	advmod	also,revealed
R6924	T11243	T11244	det	a,number
R6925	T11244	T11229	dobj	number,revealed
R6926	T11047	T11046	pobj	livers,in
R6927	T11245	T11244	prep	of,number
R6928	T11246	T11245	pobj	genes,of
R6929	T11048	T11047	prep	from,livers
R6930	T11247	T11248	dep	that,were
R6931	T11248	T11246	relcl	were,genes
R6932	T11249	T11248	acomp	responsive,were
R6933	T11049	T11050	amod	adult,mice
R6934	T11250	T11249	prep	to,responsive
R6935	T11251	T11252	compound	cadmium,exposure
R6936	T11050	T11048	pobj	mice,from
R6937	T11252	T11250	pobj	exposure,to
R6938	T11253	T11248	punct	", ",were
R6939	T11254	T11248	advcl	independent,were
R6940	T11051	T11050	nmod	Mtf1loxP,mice
R6941	T11255	T11254	prep	of,independent
R6942	T11256	T11257	det	the,presence
R6943	T11257	T11255	pobj	presence,of
R6944	T11264	T11229	punct	.,revealed
R6945	T11258	T11257	cc	or,presence
R6946	T11259	T11257	conj	absence,presence
R6947	T11266	T11267	nsubj	Evidence,is
R6948	T11260	T11257	prep	of,presence
R6949	T11261	T11260	pobj	MTF,of
R6950	T11262	T11261	punct	-,MTF
R6951	T11263	T11261	nummod	1,MTF
R6952	T11268	T11266	acl	suggests,Evidence
R6953	T11269	T11270	mark	that,is
R6954	T11270	T11268	ccomp	is,suggests
R6955	T11370	T11368	dobj	turnover,has
R6956	T11371	T11372	advmod	extremely,slow
R6957	T11372	T11370	amod	slow,turnover
R6958	T11373	T11374	punct	(,76
R6959	T11374	T11370	parataxis	76,turnover
R6960	T11271	T11272	det	the,production
R6961	T11375	T11374	nummod	75,76
R6962	T11376	T11374	punct	",",76
R6963	T11377	T11374	punct	),76
R6964	T11272	T11270	nsubj	production,is
R6965	T11378	T11350	punct	.,tends
R6966	T11380	T11381	advmod	Furthermore,provide
R6967	T11273	T11272	prep	of,production
R6968	T11382	T11381	punct	", ",provide
R6969	T11274	T11275	amod	reactive,species
R6970	T11383	T11381	nsubj	metallothioneins,provide
R6971	T11384	T11381	dobj	protection,provide
R6972	T11275	T11273	pobj	species,of
R6973	T11385	T11384	prep	against,protection
R6974	T11386	T11387	amod	oxidative,stress
R6975	T11387	T11385	pobj	stress,against
R6976	T11276	T11275	compound	oxygen,species
R6977	T11388	T11389	punct	(,17
R6978	T11389	T11381	parataxis	17,provide
R6979	T11390	T11389	nummod	1,17
R6980	T11277	T11278	det	a,effect
R6981	T11391	T11389	punct	",",17
R6982	T11392	T11389	punct	),17
R6983	T11393	T11381	punct	.,provide
R6984	T11278	T11270	attr	effect,is
R6985	T11395	T11396	prep	In,postulated
R6986	T11279	T11278	amod	major,effect
R6987	T11397	T11395	pobj	addition,In
R6988	T11398	T11397	prep	to,addition
R6989	T11280	T11278	prep	of,effect
R6990	T11399	T11398	pobj	metallothioneins,to
R6991	T11400	T11396	punct	", ",postulated
R6992	T11401	T11396	nsubjpass	glutathione,postulated
R6993	T11281	T11282	amod	acute,toxicity
R6994	T11402	T11396	auxpass	was,postulated
R6995	T11282	T11280	pobj	toxicity,of
R6996	T11403	T11396	prep	as,postulated
R6997	T11404	T11405	det	a,line
R6998	T11405	T11403	pobj	line,as
R6999	T11406	T11405	amod	first,line
R7000	T11283	T11282	compound	cadmium,toxicity
R7001	T11407	T11405	prep	of,line
R7002	T11408	T11407	pobj	defense,of
R7003	T11409	T11408	prep	against,defense
R7004	T11284	T11285	punct	(,69
R7005	T11410	T11411	compound	cadmium,toxicity
R7006	T11411	T11409	pobj	toxicity,against
R7007	T11412	T11413	punct	(,77
R7008	T11285	T11270	parataxis	69,is
R7009	T11413	T11396	parataxis	77,postulated
R7010	T11414	T11413	punct	),77
R7011	T11415	T11396	punct	.,postulated
R7012	T11286	T11285	nummod	68,69
R7013	T11417	T11418	nsubj	Glutathione,complexes
R7014	T11287	T11285	punct	",",69
R7015	T11419	T11418	advmod	efficiently,complexes
R7016	T11420	T11418	dobj	cadmium,complexes
R7017	T11421	T11422	punct	(,78
R7018	T11288	T11285	punct	),69
R7019	T11422	T11418	parataxis	78,complexes
R7020	T11423	T11422	punct	),78
R7021	T11289	T11267	punct	", ",is
R7022	T11424	T11418	cc	and,complexes
R7023	T11425	T11418	conj	scavenges,complexes
R7024	T11426	T11427	amod	free,radicals
R7025	T11290	T11267	cc	and,is
R7026	T11427	T11425	dobj	radicals,scavenges
R7027	T11428	T11427	cc	and,radicals
R7028	T11429	T11430	amod	other,species
R7029	T11291	T11267	nsubj	exposure,is
R7030	T11430	T11427	conj	species,radicals
R7031	T11431	T11430	amod	reactive,species
R7032	T11432	T11430	compound	oxygen,species
R7033	T11292	T11291	prep	of,exposure
R7034	T11433	T11425	advmod	directly,scavenges
R7035	T11434	T11433	punct	", ",directly
R7036	T11435	T11433	cc	and,directly
R7037	T11293	T11294	amod	cultured,cells
R7038	T11436	T11433	conj	indirectly,directly
R7039	T11437	T11425	prep	via,scavenges
R7040	T11438	T11439	amod	enzymatic,reactions
R7041	T11294	T11292	pobj	cells,of
R7042	T11439	T11437	pobj	reactions,via
R7043	T11440	T11441	punct	(,45
R7044	T11295	T11294	cc	or,cells
R7045	T11441	T11425	parataxis	45,scavenges
R7046	T11442	T11441	punct	),45
R7047	T11443	T11418	punct	.,complexes
R7048	T11296	T11294	conj	animals,cells
R7049	T11445	T11446	prep	In,oxidized
R7050	T11297	T11291	prep	to,exposure
R7051	T11447	T11448	amod	such,reactions
R7052	T11448	T11445	pobj	reactions,In
R7053	T11298	T11297	pobj	cadmium,to
R7054	T11449	T11446	punct	", ",oxidized
R7055	T11450	T11446	nsubjpass	glutathione,oxidized
R7056	T11451	T11446	auxpass	is,oxidized
R7057	T11299	T11267	acomp	associated,is
R7058	T11452	T11446	cc	and,oxidized
R7059	T11453	T11446	conj	has,oxidized
R7060	T11454	T11455	aux	to,regenerated
R7061	T11455	T11453	xcomp	regenerated,has
R7062	T11456	T11455	auxpass	be,regenerated
R7063	T11457	T11455	agent	by,regenerated
R7064	T11300	T11299	prep	with,associated
R7065	T11458	T11459	compound	glutathione,reductase
R7066	T11459	T11457	pobj	reductase,by
R7067	T11460	T11446	punct	.,oxidized
R7068	T11301	T11300	pobj	depletion,with
R7069	T11462	T11463	advmod	Also,mediate
R7070	T11302	T11301	prep	of,depletion
R7071	T11464	T11463	punct	", ",mediate
R7072	T11465	T11466	compound	glutathione,transferases
R7073	T11466	T11463	nsubj	transferases,mediate
R7074	T11303	T11304	amod	reduced,glutathione
R7075	T11467	T11466	punct	-,transferases
R7076	T11468	T11466	compound	S,transferases
R7077	T11304	T11302	pobj	glutathione,of
R7078	T11469	T11466	punct	-,transferases
R7079	T11470	T11471	det	the,conjugation
R7080	T11471	T11463	dobj	conjugation,mediate
R7081	T11305	T11304	punct	", ",glutathione
R7082	T11472	T11471	prep	of,conjugation
R7083	T11473	T11474	amod	various,electrophiles
R7084	T11474	T11472	pobj	electrophiles,of
R7085	T11306	T11307	compound	lipid,peroxidation
R7086	T11307	T11304	conj	peroxidation,glutathione
R7087	T11308	T11307	cc	and,peroxidation
R7088	T11309	T11310	compound	DNA,damage
R7089	T11475	T11471	prep	to,conjugation
R7090	T11310	T11307	conj	damage,peroxidation
R7091	T11311	T11312	punct	(,70
R7092	T11476	T11475	pobj	glutathione,to
R7093	T11312	T11310	parataxis	70,damage
R7094	T11477	T11463	punct	.,mediate
R7095	T11313	T11314	punct	–,73
R7096	T11479	T11480	det	The,upregulation
R7097	T11480	T11485	nsubj	upregulation,supports
R7098	T11314	T11312	prep	73,70
R7099	T11481	T11480	amod	observed,upregulation
R7100	T11482	T11483	npadvmod	cadmium,induced
R7101	T11483	T11480	amod	induced,upregulation
R7102	T11315	T11312	punct	),70
R7103	T11484	T11483	punct	-,induced
R7104	T11486	T11480	prep	of,upregulation
R7105	T11316	T11267	punct	.,is
R7106	T11487	T11486	pobj	Gclc,of
R7107	T11488	T11487	punct	", ",Gclc
R7108	T11318	T11319	amod	Oxidative,stress
R7109	T11489	T11487	conj	Gsr,Gclc
R7110	T11490	T11489	cc	and,Gsr
R7111	T11491	T11489	conj	Gstm4,Gsr
R7112	T11492	T11493	det	the,importance
R7113	T11493	T11485	dobj	importance,supports
R7114	T11494	T11493	prep	of,importance
R7115	T11495	T11494	pobj	glutathione,of
R7116	T11319	T11320	nsubjpass	stress,shown
R7117	T11496	T11493	prep	in,importance
R7118	T11497	T11498	det	the,response
R7119	T11498	T11496	pobj	response,in
R7120	T11321	T11319	cc	and,stress
R7121	T11499	T11498	amod	cellular,response
R7122	T11500	T11498	compound	cadmium,response
R7123	T11501	T11485	punct	.,supports
R7124	T11322	T11323	det	the,restoration
R7125	T11323	T11319	conj	restoration,stress
R7126	T11503	T11504	det	The,sensitivity
R7127	T11504	T11506	nsubj	sensitivity,corroborates
R7128	T11324	T11323	amod	subsequent,restoration
R7129	T11505	T11504	amod	enhanced,sensitivity
R7130	T11325	T11323	prep	of,restoration
R7131	T11507	T11504	prep	to,sensitivity
R7132	T11508	T11509	compound	cadmium,toxicity
R7133	T11509	T11507	pobj	toxicity,to
R7134	T11326	T11327	amod	cellular,homeostasis
R7135	T11510	T11511	dep	that,found
R7136	T11511	T11504	relcl	found,sensitivity
R7137	T11512	T11511	nsubj	we,found
R7138	T11327	T11325	pobj	homeostasis,of
R7139	T11513	T11511	prep	for,found
R7140	T11514	T11515	nmod	mouse,fibroblasts
R7141	T11328	T11320	aux	have,shown
R7142	T11515	T11513	pobj	fibroblasts,for
R7143	T11516	T11515	amod	embryonic,fibroblasts
R7144	T11517	T11511	prep	upon,found
R7145	T11329	T11320	auxpass	been,shown
R7146	T11518	T11519	det	a,combination
R7147	T11519	T11517	pobj	combination,upon
R7148	T11520	T11519	prep	of,combination
R7149	T11330	T11331	aux	to,induce
R7150	T11521	T11522	compound	Mtf1,deletion
R7151	T11522	T11520	pobj	deletion,of
R7152	T11331	T11320	xcomp	induce,shown
R7153	T11523	T11522	cc	and,deletion
R7154	T11524	T11522	conj	depletion,deletion
R7155	T11525	T11524	prep	of,depletion
R7156	T11332	T11333	det	the,expression
R7160	T11333	T11331	dobj	expression,induce
R7161	T11529	T11506	dobj	importance,corroborates
R7162	T11530	T11529	prep	of,importance
R7163	T11531	T11530	pobj	MTF,of
R7164	T11532	T11531	punct	-,MTF
R7165	T11533	T11531	nummod	1,MTF
R7166	T11334	T11333	prep	of,expression
R7167	T11534	T11531	cc	and,MTF
R7168	T11535	T11536	poss	its,genes
R7169	T11536	T11531	conj	genes,MTF
R7170	T11335	T11334	pobj	genes,of
R7171	T11537	T11536	compound	target,genes
R7172	T11538	T11539	advmod	as,as
R7173	T11539	T11531	cc	as,MTF
R7174	T11336	T11335	acl	encoding,genes
R7175	T11540	T11539	advmod	well,as
R7176	T11337	T11338	amod	acute,phase
R7177	T11541	T11542	amod	reduced,glutathione
R7178	T11338	T11340	compound	phase,proteins
R7179	T11542	T11531	conj	glutathione,MTF
R7180	T11543	T11529	prep	for,importance
R7181	T11544	T11545	det	an,defense
R7182	T11339	T11338	punct	-,phase
R7183	T11545	T11543	pobj	defense,for
R7184	T11546	T11545	amod	efficient,defense
R7185	T11547	T11545	amod	anti-cadmium,defense
R7186	T11340	T11336	dobj	proteins,encoding
R7187	T11548	T11506	punct	.,corroborates
R7188	T11341	T11340	cc	and,proteins
R7189	T11550	T11551	poss	Our,data
R7190	T11551	T11552	nsubj	data,provide
R7191	T11342	T11343	amod	antioxidant,enzymes
R7192	T11553	T11554	amod	strong,evidence
R7193	T11554	T11552	dobj	evidence,provide
R7194	T11555	T11552	prep	for,provide
R7195	T11343	T11340	conj	enzymes,proteins
R7196	T11556	T11557	advmod	at,two
R7197	T11557	T11559	nummod	two,branches
R7198	T11558	T11557	advmod	least,two
R7199	T11344	T11345	punct	(,74
R7200	T11559	T11555	pobj	branches,for
R7201	T11560	T11559	prep	of,branches
R7202	T11561	T11562	amod	cellular,defense
R7203	T11345	T11331	parataxis	74,induce
R7204	T11562	T11560	pobj	defense,of
R7205	T11563	T11562	amod	anti-cadmium,defense
R7206	T11564	T11559	punct	", ",branches
R7207	T11346	T11345	punct	),74
R7208	T11565	T11559	appos	one,branches
R7209	T11566	T11565	prep	via,one
R7210	T11567	T11566	pobj	MTF,via
R7211	T11347	T11320	punct	.,shown
R7212	T11568	T11567	punct	-,MTF
R7213	T11569	T11567	nummod	1,MTF
R7214	T11570	T11567	cc	and,MTF
R7215	T11349	T11350	prep	In,tends
R7216	T11571	T11572	poss	its,genes
R7217	T11572	T11567	conj	genes,MTF
R7218	T11573	T11572	compound	target,genes
R7219	T11574	T11572	punct	", ",genes
R7220	T11575	T11576	advmod	notably,metallothioneins
R7221	T11576	T11572	appos	metallothioneins,genes
R7222	T11351	T11349	pobj	mammals,In
R7223	T11577	T11565	punct	", ",one
R7224	T11578	T11579	det	the,other
R7225	T11579	T11565	appos	other,one
R7226	T11580	T11579	prep	via,other
R7227	T11352	T11350	punct	", ",tends
R7228	T11353	T11350	nsubj	cadmium,tends
R7229	T11581	T11580	pobj	glutathione,via
R7230	T11582	T11579	punct	", ",other
R7231	T11354	T11355	aux	to,accumulate
R7232	T11583	T11579	prep	with,other
R7233	T11584	T11585	det	an,overlap
R7234	T11585	T11583	pobj	overlap,with
R7235	T11355	T11350	xcomp	accumulate,tends
R7236	T11586	T11585	amod	apparent,overlap
R7237	T11356	T11355	prep	in,accumulate
R7239	T11357	T11358	det	the,kidney
R7242	T11358	T11356	pobj	kidney,in
R7243	T11359	T11358	cc	and,kidney
R7244	T11360	T11358	conj	liver,kidney
R7245	T11361	T11355	prep	as,accumulate
R7246	T11362	T11363	det	a,complex
R7247	T11363	T11361	pobj	complex,as
R7248	T11364	T11365	compound	cadmium,metallothionein
R7249	T11365	T11363	compound	metallothionein,complex
R7250	T11366	T11365	punct	-,metallothionein
R7251	T11367	T11368	dep	that,has
R7252	T11368	T11363	relcl	has,complex
R7253	T11369	T11370	det	an,turnover
R1329	T2196	T2190	appos	cre,transgene
R1470	T2341	T2322	conj	H2O,CdSO4
R3991	T6082	T6076	pobj	mice,of
R1577	T2628	T2626	pobj	Kit,with
R1721	T2786	T2782	dobj	genes,obtain
R2161	T3430	T3425	dobj	oligonucleotides,incubating
R3637	T5667	T5680	ccomp	revealed,contain
R991	T1671	T1668	pobj	response,In
R6825	T11165	T11163	pobj	expression,to
R7157	T11526	T11525	pobj	glutathione,of
R7158	T11527	T11506	advmod	further,corroborates
R7159	T11528	T11529	det	the,importance
R7238	T11587	T11585	prep	in,overlap
R7240	T11588	T11587	pobj	Sepw1,in
R7241	T11589	T11552	punct	.,provide

2_test

Id	Subject	Object	Predicate	Lexical cue
16221973-9671693-77403393	480-481	9671693	denotes	1
16221973-10742189-77403393	480-481	10742189	denotes	1
16221973-14643422-77403393	480-481	14643422	denotes	1
16221973-8026472-77403394	693-694	8026472	denotes	4
16221973-8824273-77403394	693-694	8824273	denotes	4
16221973-11746217-77403394	693-694	11746217	denotes	4
16221973-11554446-77403394	693-694	11554446	denotes	4
16221973-6095286-77403395	891-892	6095286	denotes	8
16221973-2993866-77403396	893-894	2993866	denotes	9
16221973-8467794-77403397	981-983	8467794	denotes	10
16221973-8065932-77403398	994-996	8065932	denotes	11
16221973-11416130-77403399	1011-1013	11416130	denotes	12
16221973-12505988-77403399	1011-1013	12505988	denotes	12
16221973-15833915-77403399	1011-1013	15833915	denotes	12
16221973-10195425-77403400	1028-1030	10195425	denotes	15
16221973-11866436-77403401	1031-1033	11866436	denotes	16
16221973-8824273-77403402	1255-1256	8824273	denotes	5
16221973-10605938-77403403	1257-1259	10605938	denotes	17
16221973-10096565-77403404	1274-1276	10096565	denotes	18
16221973-10952993-77403405	1412-1414	10952993	denotes	19
16221973-11289150-77403406	1573-1575	11289150	denotes	20
16221973-15284217-77403407	1630-1632	15284217	denotes	21
16221973-15516976-77403408	1633-1635	15516976	denotes	22
16221973-9582278-77403409	1819-1821	9582278	denotes	23
16221973-8367468-77403410	1964-1966	8367468	denotes	24
16221973-8290567-77403411	1967-1969	8290567	denotes	25
16221973-15226267-77403412	2360-2362	15226267	denotes	26
16221973-2440339-77403413	6127-6129	2440339	denotes	27
16221973-12519945-77403414	7821-7823	12519945	denotes	28
16221973-390497-77403415	8638-8640	390497	denotes	29
16221973-8467794-77403416	9363-9365	8467794	denotes	10
16221973-8467794-77403417	10244-10246	8467794	denotes	10
16221973-8467794-77403418	10377-10379	8467794	denotes	10
16221973-8467794-77403419	11138-11140	8467794	denotes	10
16221973-4705382-77403420	12028-12030	4705382	denotes	30
16221973-38242-77403421	12892-12894	38242	denotes	31
16221973-7660125-77403422	13821-13823	7660125	denotes	32
16221973-7660125-77403423	13965-13967	7660125	denotes	32
16221973-11376163-77403424	15615-15617	11376163	denotes	33
16221973-8026472-77403425	17906-17907	8026472	denotes	4
16221973-8824273-77403426	17908-17909	8824273	denotes	5
16221973-6095286-77403427	17910-17911	6095286	denotes	8
16221973-10096565-77403428	17912-17914	10096565	denotes	18
16221973-10952993-77403429	17915-17917	10952993	denotes	19
16221973-15318811-77403430	18120-18122	15318811	denotes	34
16221973-8576706-77403431	18543-18545	8576706	denotes	35
16221973-12062442-77403432	18596-18598	12062442	denotes	36
16221973-9605764-77403433	20120-20122	9605764	denotes	37
16221973-10910041-77403433	20120-20122	10910041	denotes	37
16221973-11059752-77403433	20120-20122	11059752	denotes	37
16221973-15341671-77403433	20120-20122	15341671	denotes	37
16221973-7954791-77403434	21611-21613	7954791	denotes	41
16221973-12530967-77403435	21614-21616	12530967	denotes	42
16221973-15189117-77403436	22771-22773	15189117	denotes	43
16221973-14988435-77403437	24917-24919	14988435	denotes	45
16221973-14988435-77403438	24999-25001	14988435	denotes	45
16221973-14988435-77403439	25144-25146	14988435	denotes	45
16221973-11746217-77403440	25393-25394	11746217	denotes	6
16221973-38242-77403441	25765-25767	38242	denotes	31
16221973-14980055-77403442	26593-26595	14980055	denotes	46
16221973-12821650-77403443	26700-26702	12821650	denotes	47
16221973-14628070-77403444	26802-26804	14628070	denotes	48
16221973-15226267-77403445	27074-27076	15226267	denotes	26
16221973-9582278-77403446	27145-27147	9582278	denotes	23
16221973-8026472-77403447	27499-27500	8026472	denotes	4
16221973-11746217-77403448	27501-27502	11746217	denotes	6
16221973-8576706-77403449	27701-27703	8576706	denotes	35
16221973-12062442-77403450	27871-27873	12062442	denotes	36
16221973-12161305-77403451	27906-27908	12161305	denotes	49
16221973-12161305-77403452	28185-28187	12161305	denotes	49
16221973-15337603-77403453	28272-28274	15337603	denotes	50
16221973-10381566-77403454	28654-28656	10381566	denotes	51
16221973-9605764-77403455	28835-28837	9605764	denotes	37
16221973-10910041-77403455	28835-28837	10910041	denotes	37
16221973-11059752-77403455	28835-28837	11059752	denotes	37
16221973-15341671-77403455	28835-28837	15341671	denotes	37
16221973-9766676-77403456	28841-28843	9766676	denotes	52
16221973-10428464-77403457	28844-28846	10428464	denotes	53
16221973-15341671-77403458	28978-28980	15341671	denotes	40
16221973-1469049-77403459	29805-29807	1469049	denotes	54
16221973-8294495-77403459	29805-29807	8294495	denotes	54
16221973-9314536-77403459	29805-29807	9314536	denotes	54
16221973-10926853-77403459	29805-29807	10926853	denotes	54
16221973-10090149-77403460	29894-29896	10090149	denotes	58
16221973-12518998-77403461	30033-30035	12518998	denotes	59
16221973-11522379-77403462	30249-30251	11522379	denotes	60
16221973-8026472-77403463	30696-30697	8026472	denotes	4
16221973-10952993-77403464	30698-30700	10952993	denotes	19
16221973-15189117-77403465	30804-30806	15189117	denotes	43
16221973-10681536-77403466	31093-31095	10681536	denotes	61
16221973-14525987-77403466	31093-31095	14525987	denotes	61
16221973-15722412-77403466	31093-31095	15722412	denotes	61
16221973-10952993-77403467	31344-31346	10952993	denotes	19
16221973-15189117-77403468	31643-31645	15189117	denotes	43
16221973-14976557-77403469	32307-32309	14976557	denotes	64
16221973-11266553-77403470	32884-32886	11266553	denotes	65
16221973-10202132-77403471	32997-32999	10202132	denotes	66
16221973-12006103-77403472	33160-33162	12006103	denotes	67
16221973-11895129-77403473	34447-34449	11895129	denotes	68
16221973-11394715-77403474	34450-34452	11394715	denotes	69
16221973-9149117-77403475	34596-34598	9149117	denotes	70
16221973-8560492-77403475	34596-34598	8560492	denotes	70
16221973-8981039-77403475	34596-34598	8981039	denotes	70
16221973-9931285-77403475	34596-34598	9931285	denotes	70
16221973-10331077-77403476	34781-34783	10331077	denotes	74
16221973-1746026-77403477	34924-34926	1746026	denotes	75
16221973-9187512-77403478	34927-34929	9187512	denotes	76
16221973-9671693-77403479	35007-35008	9671693	denotes	1
16221973-10605938-77403480	35009-35011	10605938	denotes	17
16221973-2887478-77403481	35127-35129	2887478	denotes	77
16221973-8068556-77403482	35175-35177	8068556	denotes	78
16221973-14988435-77403483	35291-35293	14988435	denotes	45

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T717	17-26	NCBITaxon:1	denotes	organisms
T718	269-273	CHEBI:29105	denotes	Zn2+
T719	275-279	CHEBI:29036	denotes	Cu2+
T720	284-288	CHEBI:48775	denotes	Cd2+
T721	392-403	GO:0042592	denotes	homeostasis
T722	408-422	GO:0098754	denotes	detoxification
T723	474-478	CHEBI:24870	denotes	ions
T724	493-498	NCBITaxon:10088	denotes	mouse
T725	531-536	SO:0000704	denotes	genes
T726	552-555	PR:000010925	denotes	Mt1
T727	559-562	PR:000010706	denotes	Mt4
T728	603-613	GO:0010467	denotes	expression
T729	617-620	PR:000010925	denotes	Mt1
T730	625-628	PR:000010704	denotes	Mt2
T731	644-683	PR:000010717	denotes	metal-responsive transcription factor 1
T732	685-690	PR:000010717	denotes	MTF-1
T733	810-819	SO:0000993	denotes	consensus
T734	864-873	SO:0000167	denotes	promoters
T735	884-889	SO:0000704	denotes	genes
T736	897-902	PR:000010717	denotes	MTF-1
T737	934-942	SO:0000853	denotes	homologs
T738	974-979	NCBITaxon:10088	denotes	mouse
T739	986-992	NCBITaxon:9606	denotes	humans
T740	999-1009	NCBITaxon:7215	denotes	Drosophila
T741	1048-1053	PR:000010717	denotes	MTF-1
T742	1095-1100	NCBITaxon:10088	denotes	mouse
T743	1140-1145	PR:000010717	denotes	MTF-1
T744	1183-1188	SO:0000704	denotes	genes
T745	1237-1246	MOP:0000568	denotes	oxidative
T746	1336-1340	PR:000015073	denotes	Znt1
T747	1361-1376	GO:0005886	denotes	plasma membrane
T748	1453-1457	SO:0000704	denotes	gene
T749	1462-1471	UBERON:0001987	denotes	placental
T750	1462-1485	PR:000012605	denotes	placental growth factor
T751	1487-1491	PR:000012605	denotes	Plgf
T752	1497-1507	GO:0001525	denotes	angiogenic
T753	1532-1543	UBERON:0001986	denotes	endothelial
T754	1651-1656	PR:000010717	denotes	MTF-1
T755	1690-1703	GO:0009790	denotes	embryogenesis
T756	1728-1732	PR:000010717	denotes	Mtf1
T757	1744-1753	UBERON:0000922	denotes	embryonic
T758	1784-1790	GO:0007620	denotes	coitum
T759	1798-1808	CL:0000182	denotes	hepatocyte
T760	1837-1841	NCBITaxon:10088	denotes	mice
T761	1903-1908	SO:0000704	denotes	genes
T762	1910-1913	PR:000010925	denotes	Mt1
T763	1918-1921	PR:000010704	denotes	Mt2
T764	2009-2014	PR:000010717	denotes	MTF-1
T765	2022-2027	SO:0000704	denotes	genes
T766	2079-2083	SO:0000346	denotes	loxP
T767	2149-2158	UBERON:0000922	denotes	embryonic
T768	2192-2196	PR:000010717	denotes	Mtf1
T769	2206-2210	NCBITaxon:10088	denotes	mice
T770	2279-2283	PR:000010717	denotes	Mtf1
T771	2293-2298	UBERON:0002107	denotes	liver
T772	2305-2310	GO:0007567	denotes	birth
T773	2395-2400	UBERON:0002107	denotes	liver
T774	2410-2414	PR:000010717	denotes	Mtf1
T775	2424-2429	NCBITaxon:10088	denotes	mouse
T776	2473-2478	PR:000010717	denotes	MTF-1
T777	2486-2491	SO:0000704	denotes	genes
T778	2514-2519	SO:0000704	denotes	genes
T779	2527-2532	UBERON:0007023	denotes	adult
T780	2533-2538	UBERON:0002107	denotes	liver
T781	2559-2563	SO:0000704	denotes	gene
T782	2642-2646	PR:000010717	denotes	Mtf1
T783	2668-2672	NCBITaxon:10088	denotes	mice
T784	2806-2811	SO:0000704	denotes	genes
T785	2846-2851	SO:0000704	denotes	genes
T786	2855-2860	PR:000010717	denotes	MTF-1
T787	2875-2880	PR:000010717	denotes	MTF-1
T788	2904-2909	UBERON:0002107	denotes	liver
T789	2910-2920	GO:0010467	denotes	expression
T790	2928-2932	SO:0000704	denotes	gene
T791	2937-2962	PR:000014662	denotes	selenoprotein W, muscle 1
T792	2964-2969	PR:000014662	denotes	Sepw1
T793	3002-3012	GO:0010467	denotes	expression
T794	3016-3049	PR:000011059	denotes	N-myc downstream regulated gene 1
T795	3033-3042	GO:0065007	denotes	regulated
T796	3043-3047	SO:0000704	denotes	gene
T797	3051-3056	PR:000011059	denotes	Ndrg1
T798	3066-3070	SO:0000704	denotes	gene
T799	3080-3116	PR:000005958	denotes	cysteine- and glycine-rich protein 1
T800	3118-3123	PR:000005958	denotes	Csrp1
T801	3139-3144	PR:000010717	denotes	MTF-1
T802	3168-3178	GO:0010467	denotes	expression
T803	3182-3217	PR:000015124	denotes	solute carrier family 39, member 10
T804	3218-3222	SO:0000704	denotes	gene
T805	3224-3232	PR:000015124	denotes	Slc39a10
T806	3266-3269	CHEBI:24870	denotes	ion
T807	3289-3294	PR:000010717	denotes	MTF-1
T808	3339-3344	SO:0000704	denotes	genes
T809	3357-3368	CHEBI:16856	denotes	glutathione
T810	3357-3379	GO:0006749	denotes	glutathione metabolism
T811	3439-3446	GO:0006952	denotes	defense
T812	3456-3467	CHEBI:16856	denotes	glutathione
T813	3488-3493	PR:000010717	denotes	MTF-1
T814	3509-3514	SO:0000704	denotes	genes
T1969	3582-3586	PR:000010717	denotes	Mtf1
T1970	3608-3612	NCBITaxon:10088	denotes	mice
T1971	3617-3622	UBERON:0002107	denotes	liver
T1972	3641-3645	PR:000010717	denotes	Mtf1
T1973	3667-3671	NCBITaxon:10088	denotes	mice
T1974	3750-3764	SO:0000040	denotes	genomic clones
T1975	3776-3781	SO:0000147	denotes	exons
T1976	3792-3796	PR:000010717	denotes	Mtf1
T1977	3822-3826	SO:0000704	denotes	gene
T1978	3827-3843	SO:0001644	denotes	targeting vector
T1979	3897-3905	CHEBI:7507	denotes	neomycin
T1980	3917-3925	SO:0005853	denotes	cassette
T1981	3936-3943	SO:0000357	denotes	flanked
T1982	3951-3961	SO:0000346	denotes	loxP sites
T1983	3998-4002	SO:0000147	denotes	exon
T1984	4008-4012	PR:000010717	denotes	Mtf1
T1985	4024-4033	SO:0000346	denotes	loxP site
T1986	4070-4074	SO:0000147	denotes	exon
T1987	4102-4110	SO:0005853	denotes	cassette
T1988	4147-4151	SO:0000147	denotes	exon
T1989	4159-4167	CL:0002322	denotes	ES cells
T1990	4208-4224	SO:0001644	denotes	targeting vector
T1991	4254-4258	CHEBI:42768	denotes	G418
T1992	4358-4368	GO:0010467	denotes	expression
T1993	4418-4426	SO:0005853	denotes	cassette
T1994	4432-4436	NCBITaxon:10088	denotes	mice
T1995	4459-4463	PR:000010717	denotes	Mtf1
T1996	4463-4467	SO:0000346	denotes	loxP
T1997	4468-4474	SO:0001023	denotes	allele
T1998	4535-4546	UBERON:0000358	denotes	blastocysts
T1999	4603-4610	NCBITaxon:33208	denotes	animals
T2000	4612-4616	PR:000010717	denotes	Mtf1
T2001	4616-4620	SO:0000346	denotes	loxP
T2002	4621-4625	SO:0000346	denotes	loxP
T2003	4681-4683	PR:000010788	denotes	Mx
T2004	4745-4750	UBERON:0002107	denotes	liver
T2005	4760-4764	PR:000010717	denotes	Mtf1
T2006	4784-4788	NCBITaxon:10088	denotes	mice
T2007	4831-4838	SO:0000112	denotes	primers
T2008	4935-4939	PR:000010717	denotes	Mtf1
T2009	4939-4943	SO:0000346	denotes	loxP
T2010	4957-4963	SO:0001023	denotes	allele
T2371	5215-5219	SO:0000346	denotes	loxP
T2372	5220-5224	SO:0000346	denotes	loxP
T2373	5233-5237	PR:000010717	denotes	Mtf1
T2374	5237-5241	SO:0000346	denotes	loxP
T2375	5262-5272	UBERON:0001179	denotes	peritoneal
T2376	5309-5324	SO:0000985	denotes	double-stranded
T2377	5329-5341	_FRAGMENT	denotes	polyinosinic
T2378	5356-5360	CHEBI:76777	denotes	acid
T2379	5362-5364	CHEBI:76777	denotes	pI
T2380	5514-5519	PR:000010717	denotes	MTF-1
T2381	5527-5531	SO:0000704	denotes	gene
T2382	5556-5560	NCBITaxon:10088	denotes	mice
T2383	5573-5575	CHEBI:76777	denotes	pI
T2384	5629-5633	NCBITaxon:10088	denotes	mice
T2385	5665-5667	CHEBI:76777	denotes	pI
T2386	5746-5751	CHEBI:50292	denotes	CdSO4
T2387	5758-5763	CHEBI:50292	denotes	CdSO4
T2388	5767-5770	CHEBI:15377	denotes	H2O
T2389	5815-5818	CHEBI:15377	denotes	H2O
T2458	5934-5939	UBERON:0002107	denotes	liver
T2459	5940-5946	UBERON:0000479	denotes	tissue
T2460	5950-5952	CHEBI:76777	denotes	pI
T2461	5990-5994	PR:000010717	denotes	Mtf1
T2462	5994-5996	PR:000010788	denotes	Mx
T2463	6005-6009	PR:000010717	denotes	Mtf1
T2464	6009-6013	SO:0000346	denotes	loxP
T2465	6014-6018	NCBITaxon:10088	denotes	mice
T2466	6132-6136	SO:0000704	denotes	Gene
T2467	6132-6147	GO:0010467	denotes	Gene expression
T2468	6228-6233	NCBITaxon:10088	denotes	Mouse
T2469	6234-6240	SO:0001026	denotes	Genome
T2470	6332-6340	CHEBI:33893	denotes	reagents
T2471	6396-6411	SO:0000985	denotes	Double-Stranded
T2472	6536-6546	SO:0000673	denotes	Transcript
T2473	7164-7169	PR:000010717	denotes	MTF-1
T2474	7182-7187	SO:0000704	denotes	genes
T2475	7189-7194	SO:0000704	denotes	Genes
T2476	7232-7241	GO:0010467	denotes	expressed
T2477	7287-7297	GO:0010467	denotes	expression
T2478	7449-7453	SO:0000704	denotes	gene
T2479	7493-7497	NCBITaxon:10088	denotes	mice
T2480	7535-7539	NCBITaxon:10088	denotes	mice
T2481	7606-7615	SO:0000993	denotes	consensus
T2482	7640-7648	SO:0000167	denotes	promoter
T2483	7698-7703	SO:0000704	denotes	genes
T2484	7770-7776	SO:0001026	denotes	Genome
T3275	9130-9135	UBERON:0002107	denotes	liver
T3276	9136-9142	UBERON:0000479	denotes	tissue
T3277	9155-9161	UBERON:0000479	denotes	Tissue
T3278	9181-9188	CHEBI:33893	denotes	Reagent
T3279	9266-9271	NCBITaxon:10088	denotes	mouse
T3280	9272-9278	UBERON:0000479	denotes	tissue
T3281	9293-9300	CHEBI:33893	denotes	reagent
T3282	9430-9433	CHEBI:37972	denotes	32P
T3283	9446-9478	SO:0000442	denotes	double-stranded oligonucleotides
T3284	9498-9503	UBERON:0002107	denotes	liver
T3285	9771-9779	GO:0097617	denotes	annealed
T3286	9808-9813	PR:000005958	denotes	Csrp1
T3287	9893-9898	PR:000005958	denotes	Csrp1
T3288	9975-9980	PR:000005958	denotes	Csrp1
T3289	10057-10062	PR:000005958	denotes	Csrp1
T3290	10139-10143	PR:P04386	denotes	Gal4
T3291	10224-10229	NCBITaxon:10088	denotes	mouse
T3292	10230-10233	PR:000010925	denotes	Mt1
T3293	10234-10242	SO:0000167	denotes	promoter
T3294	10343-10352	_FRAGMENT	denotes	synthetic
T3295	10367-10375	SO:0000351	denotes	sequence
T3296	10357-10366	SO:0000993	denotes	consensus
T3297	10469-10474	PR:000011059	denotes	Ndrg1
T3298	10547-10552	PR:000011059	denotes	Ndrg1
T3299	10625-10630	PR:000011059	denotes	Ndrg1
T3300	10734-10739	PR:000014662	denotes	Sepw1
T3301	10829-10834	PR:000014662	denotes	Sepw1
T3302	10913-10921	PR:000015124	denotes	Slc39a10
T3303	11007-11015	PR:000015124	denotes	Slc39a10
T3304	11092-11113	PR:000000133	denotes	Specificity protein 1
T3305	11115-11118	PR:000000133	denotes	Sp1
T4144	11219-11228	UBERON:0000922	denotes	embryonic
T4145	11229-11240	CL:0000057	denotes	fibroblasts
T4146	11275-11279	PR:000010717	denotes	Mtf1
T4147	11279-11283	SO:0000346	denotes	loxP
T4148	11284-11289	NCBITaxon:10088	denotes	mouse
T4149	11290-11296	UBERON:0000922	denotes	embryo
T4150	11301-11306	GO:0040007	denotes	grown
T4151	11343-11349	NCBITaxon:27592	denotes	bovine
T4152	11350-11355	UBERON:0001977	denotes	serum
T4153	11372-11382	CHEBI:17334	denotes	penicillin
T4154	11383-11395	CHEBI:17076	denotes	streptomycin
T4155	11461-11474	CL:0000001	denotes	primary cells
T4156	11480-11491	GO:0009294	denotes	transfected
T4157	11509-11519	GO:0010467	denotes	expression
T4158	11520-11527	SO:0000155	denotes	plasmid
T4159	11539-11554	NCBITaxon:10633	denotes	simian virus 40
T4160	11556-11560	NCBITaxon:10633	denotes	SV40
T4161	11570-11577	CHEBI:59132	denotes	antigen
T4162	11592-11607	NCBITaxon:10358	denotes	cytomegalovirus
T4163	11609-11612	NCBITaxon:10358	denotes	CMV
T4164	11614-11622	SO:0000167	denotes	promoter
T4165	11645-11652	CHEBI:33893	denotes	reagent
T4166	11757-11762	NCBITaxon:10088	denotes	mouse
T4167	11763-11772	UBERON:0000922	denotes	embryonic
T4168	11763-11772	_FRAGMENT	denotes	embryonic
T4169	11784-11788	CL:0002321	denotes	cell
T4170	11773-11788	CL:0000057	denotes	fibroblast cell
T4171	11833-11837	PR:000010717	denotes	Mtf1
T4172	11837-11841	SO:0000346	denotes	loxP
T4173	11879-11886	SO:0001026	denotes	genomic
T4174	11908-11915	CHEBI:59132	denotes	antigen
T4175	11983-11994	GO:0009294	denotes	transfected
T4176	12002-12019	CHEBI:77635	denotes	calcium phosphate
T4177	12051-12061	GO:0010467	denotes	expression
T4178	12062-12069	SO:0000155	denotes	plasmid
T4179	12104-12107	NCBITaxon:10358	denotes	CMV
T4180	12108-12116	SO:0000167	denotes	promoter
T4181	12134-12144	GO:0010467	denotes	expression
T4182	12145-12152	SO:0000155	denotes	plasmid
T4183	12161-12169	CHEBI:7507	denotes	neomycin
T4184	12181-12185	SO:0000704	denotes	gene
T4185	12196-12203	GO:0065007	denotes	control
T4186	12214-12222	SO:0000167	denotes	promoter
T4187	12231-12242	GO:0009294	denotes	transfected
T4188	12292-12296	CHEBI:42768	denotes	G418
T4189	12365-12370	GO:0040007	denotes	grown
T4190	12394-12404	GO:0010467	denotes	expression
T4191	12440-12445	SO:0000147	denotes	exons
T4192	12457-12461	PR:000010717	denotes	Mtf1
T4193	12547-12551	PR:000010717	denotes	Mtf1
T4505	13238-13243	UBERON:0002107	denotes	liver
T4506	13253-13257	PR:000010717	denotes	Mtf1
T4507	13267-13272	NCBITaxon:10088	denotes	mouse
T4508	13321-13325	NCBITaxon:10088	denotes	mice
T4509	13356-13360	PR:000010717	denotes	Mtf1
T4510	13361-13367	SO:0001023	denotes	allele
T4511	13368-13372	PR:000010717	denotes	Mtf1
T4512	13372-13376	SO:0000346	denotes	loxP
T4513	13383-13388	SO:0000147	denotes	exons
T4514	13455-13461	SO:0000417	denotes	domain
T4515	13467-13474	SO:0000357	denotes	flanked
T4516	13478-13488	SO:0000346	denotes	loxP sites
T4517	13502-13506	NCBITaxon:10088	denotes	Mice
T4518	13526-13530	PR:000010717	denotes	Mtf1
T4519	13530-13534	SO:0000346	denotes	loxP
T4520	13535-13541	SO:0001023	denotes	allele
T4521	13568-13575	NCBITaxon:33208	denotes	animals
T4522	13615-13617	PR:000010788	denotes	Mx
T4523	13642-13651	GO:0010467	denotes	expressed
T4524	13675-13682	GO:0065007	denotes	control
T4525	13690-13695	NCBITaxon:10088	denotes	mouse
T4526	13696-13699	PR:000010788	denotes	Mx1
T4527	13700-13704	SO:0000704	denotes	gene
T4528	13705-13713	SO:0000167	denotes	promoter
T4529	13755-13771	PR:000024938	denotes	interferon alpha
T4530	13755-13765	_FRAGMENT	denotes	interferon
T4531	13775-13779	PR:000024939	denotes	beta
T4532	13794-13809	SO:0000985	denotes	double-stranded
T4533	13814-13816	CHEBI:76777	denotes	pI
T4534	13883-13888	UBERON:0002107	denotes	liver
T4535	13913-13920	UBERON:0000479	denotes	tissues
T4536	13942-13948	UBERON:0002106	denotes	spleen
T4537	13958-13963	UBERON:0000955	denotes	brain
T4538	14001-14006	SO:0000147	denotes	exons
T4539	14060-14071	GO:0006412	denotes	translation
T4540	14092-14097	PR:000010717	denotes	MTF-1
T4541	14157-14161	PR:000010717	denotes	Mtf1
T4542	14183-14187	NCBITaxon:10088	denotes	mice
T4543	14202-14204	PR:000010788	denotes	Mx
T4544	14209-14218	SO:0000902	denotes	transgene
T4545	14220-14224	PR:000010717	denotes	Mtf1
T4546	14224-14226	PR:000010788	denotes	Mx
T4547	14251-14261	UBERON:0001179	denotes	peritoneal
T4548	14262-14264	CHEBI:76777	denotes	pI
T4549	14299-14301	CHEBI:76777	denotes	pI
T4550	14345-14354	SO:0000902	denotes	transgene
T4551	14356-14360	PR:000010717	denotes	Mtf1
T4552	14360-14364	SO:0000346	denotes	loxP
T4553	14469-14473	PR:000010717	denotes	Mtf1
T4554	14473-14475	PR:000010788	denotes	Mx
T4555	14480-14486	UBERON:0002107	denotes	livers
T4556	14524-14529	SO:0000147	denotes	exons
T4557	14541-14545	PR:000010717	denotes	Mtf1
T4558	14555-14562	NCBITaxon:33208	denotes	animals
T4559	14669-14673	NCBITaxon:10088	denotes	mice
T4560	14728-14732	PR:000010717	denotes	Mtf1
T4561	14763-14768	PR:000010717	denotes	MTF-1
T4562	14811-14816	PR:000010717	denotes	MTF-1
T4563	14817-14836	GO:0032993	denotes	protein–DNA complex
T4564	14857-14862	UBERON:0002107	denotes	liver
T4565	14887-14891	PR:000010717	denotes	Mtf1
T4566	14891-14895	SO:0000346	denotes	loxP
T4567	14904-14909	NCBITaxon:10088	denotes	mouse
T4568	14970-14974	PR:000010717	denotes	Mtf1
T4569	14974-14976	PR:000010788	denotes	Mx
T4570	15007-15012	SO:0000147	denotes	exons
T4571	15024-15028	PR:000010717	denotes	Mtf1
T4572	15036-15041	UBERON:0002107	denotes	liver
T4573	15045-15049	PR:000010717	denotes	Mtf1
T4574	15049-15051	PR:000010788	denotes	Mx
T4575	15056-15060	NCBITaxon:10088	denotes	mice
T4576	15098-15103	UBERON:0002107	denotes	liver
T4577	15122-15126	NCBITaxon:10088	denotes	mice
T5129	15189-15194	PR:000010717	denotes	MTF-1
T5130	15202-15206	SO:0000704	denotes	gene
T5131	15240-15245	PR:000010717	denotes	MTF-1
T5132	15253-15258	SO:0000704	denotes	genes
T5133	15276-15281	UBERON:0002107	denotes	liver
T5134	15282-15292	SO:0000673	denotes	transcript
T5135	15305-15309	NCBITaxon:10088	denotes	mice
T5136	15338-15342	PR:000010717	denotes	Mtf1
T5137	15343-15347	SO:0000704	denotes	gene
T5138	15467-15478	SO:0000673	denotes	transcripts
T5139	15559-15574	SO:0000985	denotes	double-stranded
T5140	15584-15605	SO:0000412	denotes	restriction fragments
T5141	15722-15725	PR:000010925	denotes	Mt1
T5142	15730-15733	PR:000010704	denotes	Mt2
T5143	15766-15777	SO:0000673	denotes	transcripts
T5144	15833-15839	UBERON:0002107	denotes	livers
T5145	15867-15872	PR:000010717	denotes	MTF-1
T5146	15873-15877	SO:0000704	denotes	gene
T5147	15936-15941	PR:000010717	denotes	MTF-1
T5148	15975-15985	GO:0010467	denotes	expression
T5149	16005-16010	SO:0000704	denotes	genes
T5150	16038-16042	SO:0000704	denotes	gene
T5151	16038-16053	GO:0010467	denotes	gene expression
T5152	16065-16071	UBERON:0002107	denotes	livers
T5153	16095-16099	NCBITaxon:10088	denotes	mice
T5154	16137-16142	NCBITaxon:10088	denotes	Mouse
T5155	16143-16149	SO:0001026	denotes	Genome
T5156	16215-16221	UBERON:0002107	denotes	livers
T5157	16240-16244	PR:000010717	denotes	Mtf1
T5158	16244-16246	PR:000010788	denotes	Mx
T5159	16255-16259	PR:000010717	denotes	Mtf1
T5160	16259-16263	SO:0000346	denotes	loxP
T5161	16264-16268	NCBITaxon:10088	denotes	mice
T5162	16299-16327	GO:0010629	denotes	downregulation of expression
T5163	16344-16348	PR:000010717	denotes	Mtf1
T5164	16348-16350	PR:000010788	denotes	Mx
T5165	16355-16361	UBERON:0002107	denotes	livers
T5166	16435-16440	SO:0000704	denotes	genes
T5167	16470-16475	SO:0000704	denotes	genes
T5168	16505-16514	SO:0000993	denotes	consensus
T5169	16557-16559	SO:0000028	denotes	bp
T5170	16659-16664	SO:0000704	denotes	genes
T5171	16724-16728	PR:000010717	denotes	Mtf1
T5172	16728-16730	PR:000010788	denotes	Mx
T5173	16735-16741	UBERON:0002107	denotes	livers
T5174	16771-16776	SO:0000704	denotes	genes
T5175	16794-16803	SO:0000993	denotes	consensus
T5176	16855-16861	UBERON:0002107	denotes	livers
T5177	16881-16885	PR:000010717	denotes	Mtf1
T5178	16885-16887	PR:000010788	denotes	Mx
T5179	16896-16900	PR:000010717	denotes	Mtf1
T5180	16900-16904	SO:0000346	denotes	loxP
T5181	16905-16909	NCBITaxon:10088	denotes	mice
T5182	16966-16970	PR:000010717	denotes	Mtf1
T5183	16970-16972	PR:000010788	denotes	Mx
T5184	16977-16983	UBERON:0002107	denotes	livers
T5185	17046-17051	SO:0000704	denotes	genes
T5186	17095-17104	SO:0000993	denotes	consensus
T5187	17201-17206	SO:0000704	denotes	genes
T5188	17339-17344	SO:0000704	denotes	genes
T5189	17346-17350	SO:0000345	denotes	ESTs
T5190	17413-17417	PR:000010717	denotes	Mtf1
T5191	17417-17419	PR:000010788	denotes	Mx
T5192	17428-17432	PR:000010717	denotes	Mtf1
T5193	17432-17436	SO:0000346	denotes	loxP
T5194	17437-17443	UBERON:0002107	denotes	livers
T5195	17465-17474	GO:0010467	denotes	expressed
T5196	17518-17521	PR:000010925	denotes	Mt1
T5197	17526-17529	PR:000010704	denotes	Mt2
T5198	17546-17550	PR:000010717	denotes	Mtf1
T5199	17550-17552	PR:000010788	denotes	Mx
T5200	17557-17563	UBERON:0002107	denotes	livers
T5201	17644-17647	PR:000010925	denotes	Mt1
T5202	17664-17671	NCBITaxon:33208	denotes	animals
T5203	17713-17718	PR:000010717	denotes	MTF-1
T5204	17726-17731	SO:0000704	denotes	genes
T5205	17762-17765	PR:000010925	denotes	Mt1
T5206	17767-17770	PR:000010704	denotes	Mt2
T5207	17775-17779	PR:000015073	denotes	Znt1
T5208	17781-17786	PR:000010717	denotes	MTF-1
T5209	17947-17952	PR:000010717	denotes	MTF-1
T5210	17953-17966	SO:0000409	denotes	binding sites
T5211	17995-18027	SO:0000442	denotes	double-stranded oligonucleotides
T5212	18083-18088	PR:000010717	denotes	MTF-1
T5213	18191-18196	PR:000010717	denotes	MTF-1
T5214	18204-18208	SO:0000704	denotes	gene
T5215	18241-18245	SO:0000704	denotes	gene
T6306	18287-18297	GO:0010467	denotes	expression
T6307	18301-18306	PR:000014662	denotes	Sepw1
T6308	18318-18323	PR:000010717	denotes	MTF-1
T6309	18324-18329	PR:000014662	denotes	Sepw1
T6310	18400-18406	UBERON:0002107	denotes	livers
T6311	18438-18442	PR:000010717	denotes	Mtf1
T6312	18442-18444	PR:000010788	denotes	Mx
T6313	18449-18453	NCBITaxon:10088	denotes	mice
T6314	18474-18479	PR:000014662	denotes	SEPW1
T6315	18530-18541	CHEBI:16856	denotes	glutathione
T6316	18601-18606	PR:000014662	denotes	Sepw1
T6317	18607-18617	GO:0010467	denotes	expression
T6318	18621-18627	UBERON:0002107	denotes	livers
T6319	18631-18633	CHEBI:76777	denotes	pI
T6320	18671-18675	PR:000010717	denotes	Mtf1
T6321	18675-18677	PR:000010788	denotes	Mx
T6322	18686-18690	PR:000010717	denotes	Mtf1
T6323	18690-18694	SO:0000346	denotes	loxP
T6324	18695-18699	NCBITaxon:10088	denotes	mice
T6325	18753-18755	PR:000025471	denotes	S1
T6326	18853-18858	PR:000014662	denotes	Sepw1
T6327	18889-18895	UBERON:0002107	denotes	livers
T6328	18901-18905	PR:000010717	denotes	Mtf1
T6329	18905-18909	SO:0000346	denotes	loxP
T6330	18910-18914	NCBITaxon:10088	denotes	mice
T6331	18970-18976	UBERON:0002107	denotes	livers
T6332	19008-19012	PR:000010717	denotes	Mtf1
T6333	19012-19014	PR:000010788	denotes	Mx
T6334	19019-19023	NCBITaxon:10088	denotes	mice
T6335	19041-19046	PR:000010717	denotes	MTF-1
T6336	19074-19084	GO:0010467	denotes	expression
T6337	19088-19093	PR:000014662	denotes	Sepw1
T6338	19110-19119	SO:0000993	denotes	consensus
T6339	19171-19176	NCBITaxon:10088	denotes	mouse
T6340	19177-19182	PR:000014662	denotes	Sepw1
T6341	19325-19327	SO:0000028	denotes	bp
T6342	19384-19386	SO:0000028	denotes	bp
T6343	19409-19414	PR:000010717	denotes	MTF-1
T6344	19418-19423	PR:000014662	denotes	Sepw1
T6345	19484-19489	UBERON:0002107	denotes	liver
T6346	19514-19518	PR:000010717	denotes	Mtf1
T6347	19518-19522	SO:0000346	denotes	loxP
T6348	19531-19536	NCBITaxon:10088	denotes	mouse
T6349	19616-19618	CHEBI:76777	denotes	pI
T6350	19630-19634	PR:000010717	denotes	Mtf1
T6351	19634-19636	PR:000010788	denotes	Mx
T6352	19641-19646	NCBITaxon:10088	denotes	mouse
T6353	19718-19723	PR:000010717	denotes	MTF-1
T6467	19746-19751	PR:000011059	denotes	Ndrg1
T6468	19763-19768	PR:000010717	denotes	MTF-1
T6469	19769-19774	PR:000011059	denotes	Ndrg1
T6470	19825-19830	UBERON:0002107	denotes	liver
T6471	19831-19842	SO:0000673	denotes	transcripts
T6472	19864-19868	PR:000010717	denotes	Mtf1
T6473	19868-19870	PR:000010788	denotes	Mx
T6474	19875-19879	NCBITaxon:10088	denotes	mice
T6475	19910-19914	PR:000010717	denotes	Mtf1
T6476	19914-19918	SO:0000346	denotes	loxP
T6477	19927-19931	NCBITaxon:10088	denotes	mice
T6478	19946-19951	PR:000011059	denotes	Ndrg1
T6479	20046-20055	CHEBI:36357	denotes	compounds
T6480	20066-20076	GO:0010467	denotes	expression
T6481	20080-20086	NCBITaxon:9989	denotes	rodent
T6482	20087-20092	PR:000011059	denotes	Ndrg1
T6483	20104-20109	NCBITaxon:9606	denotes	human
T6484	20110-20118	SO:0000855	denotes	ortholog
T6485	20132-20137	PR:000011059	denotes	Ndrg1
T6486	20219-20223	PR:000010717	denotes	Mtf1
T6487	20223-20227	SO:0000346	denotes	loxP
T6488	20236-20242	UBERON:0002107	denotes	livers
T6489	20264-20269	PR:000011059	denotes	Ndrg1
T6490	20270-20280	GO:0010467	denotes	expression
T6491	20321-20327	UBERON:0002107	denotes	livers
T6492	20333-20337	PR:000010717	denotes	Mtf1
T6493	20337-20339	PR:000010788	denotes	Mx
T6494	20344-20348	NCBITaxon:10088	denotes	mice
T6495	20404-20414	GO:0010467	denotes	expression
T6496	20476-20486	GO:0010467	denotes	expression
T6497	20490-20495	PR:000011059	denotes	Ndrg1
T6498	20507-20512	PR:000010717	denotes	MTF-1
T6499	20528-20537	SO:0000993	denotes	consensus
T6500	20576-20581	NCBITaxon:10088	denotes	mouse
T6501	20582-20587	PR:000011059	denotes	Ndrg1
T6502	20676-20678	SO:0000028	denotes	bp
T6503	20735-20737	SO:0000028	denotes	bp
T6504	20775-20780	PR:000010717	denotes	MTF-1
T6505	21010-21017	GO:0032991	denotes	complex
T6506	21051-21056	PR:000010717	denotes	MTF-1
T6507	21057-21066	GO:0032991	denotes	complexes
T6508	21132-21137	UBERON:0002107	denotes	liver
T6509	21162-21166	PR:000010717	denotes	Mtf1
T6510	21166-21170	SO:0000346	denotes	loxP
T6511	21171-21176	NCBITaxon:10088	denotes	mouse
T6512	21245-21250	NCBITaxon:10088	denotes	mouse
T6513	21259-21264	PR:000010717	denotes	MTF-1
T6514	21266-21270	PR:000010717	denotes	Mtf1
T6515	21270-21272	PR:000010788	denotes	Mx
T7152	21300-21305	PR:000005958	denotes	Csrp1
T7153	21317-21322	PR:000010717	denotes	MTF-1
T7154	21323-21328	PR:000005958	denotes	Csrp1
T7155	21415-21419	PR:000010717	denotes	Mtf1
T7156	21419-21421	PR:000010788	denotes	Mx
T7157	21426-21430	NCBITaxon:10088	denotes	mice
T7158	21443-21447	PR:000010717	denotes	Mtf1
T7159	21447-21451	SO:0000346	denotes	loxP
T7160	21452-21456	NCBITaxon:10088	denotes	mice
T7161	21471-21476	PR:000005958	denotes	CSRP1
T7162	21586-21598	GO:0005856	denotes	cytoskeletal
T7163	21691-21696	PR:000005958	denotes	Csrp1
T7164	21697-21707	GO:0010467	denotes	expression
T7165	21723-21727	PR:000010717	denotes	Mtf1
T7166	21727-21731	SO:0000346	denotes	loxP
T7167	21732-21738	UBERON:0002107	denotes	livers
T7168	21825-21831	UBERON:0002107	denotes	livers
T7169	21837-21841	PR:000010717	denotes	Mtf1
T7170	21841-21843	PR:000010788	denotes	Mx
T7171	21848-21852	NCBITaxon:10088	denotes	mice
T7172	21870-21875	PR:000010717	denotes	MTF-1
T7173	21913-21918	PR:000005958	denotes	Csrp1
T7174	21935-21944	SO:0000993	denotes	consensus
T7175	21982-21987	PR:000005958	denotes	Csrp1
T7176	22035-22037	SO:0000028	denotes	bp
T7177	22087-22089	SO:0000028	denotes	bp
T7178	22123-22128	PR:000010717	denotes	MTF-1
T7179	22205-22209	PR:000010717	denotes	Mtf1
T7180	22209-22213	SO:0000346	denotes	loxP
T7181	22214-22219	UBERON:0002107	denotes	liver
T7182	22232-22236	PR:000010717	denotes	Mtf1
T7183	22236-22238	PR:000010788	denotes	Mx
T7184	22243-22248	UBERON:0002107	denotes	liver
T7185	22265-22270	PR:000010717	denotes	MTF-1
T7186	22304-22309	PR:000010717	denotes	MTF-1
T7187	22317-22324	GO:0032991	denotes	complex
T7295	22339-22344	PR:000010717	denotes	MTF-1
T7296	22354-22364	GO:0010467	denotes	expression
T7297	22368-22376	PR:000015124	denotes	Slc39a10
T7298	22377-22385	PR:000015124	denotes	Slc39a10
T7299	22457-22463	UBERON:0002107	denotes	livers
T7300	22500-22504	PR:000010717	denotes	Mtf1
T7301	22504-22506	PR:000010788	denotes	Mx
T7302	22511-22515	NCBITaxon:10088	denotes	mice
T7303	22536-22543	NCBITaxon:33208	denotes	animals
T7304	22646-22649	CHEBI:24870	denotes	ion
T7305	22710-22713	CHEBI:24870	denotes	ion
T7306	22732-22750	GO:0005886	denotes	cellular membranes
T7307	22760-22769	GO:0005737	denotes	cytoplasm
T7308	22849-22866	_FRAGMENT	denotes	downregulation of
T7309	22876-22886	GO:0010629	denotes	expression
T7310	22867-22875	PR:000015124	denotes	Slc39a10
T7311	22890-22896	UBERON:0002107	denotes	livers
T7312	22900-22904	PR:000010717	denotes	Mtf1
T7313	22904-22908	SO:0000346	denotes	loxP
T7314	22909-22913	NCBITaxon:10088	denotes	mice
T7315	22953-22957	PR:000010717	denotes	Mtf1
T7316	22957-22959	PR:000010788	denotes	Mx
T7317	22964-22968	NCBITaxon:10088	denotes	mice
T7318	22980-22990	GO:0010467	denotes	expression
T7319	23070-23078	PR:000015124	denotes	Slc39a10
T7320	23079-23089	GO:0010467	denotes	expression
T7321	23193-23201	PR:000015124	denotes	Slc39a10
T7322	23234-23238	PR:000010717	denotes	Mtf1
T7323	23238-23240	PR:000010788	denotes	Mx
T7324	23249-23253	PR:000010717	denotes	Mtf1
T7325	23253-23257	SO:0000346	denotes	loxP
T7326	23258-23262	NCBITaxon:10088	denotes	mice
T7327	23290-23295	PR:000010717	denotes	MTF-1
T7328	23398-23404	UBERON:0002107	denotes	livers
T7329	23518-23523	PR:000010717	denotes	MTF-1
T7330	23563-23573	GO:0010467	denotes	expression
T7331	23577-23585	PR:000015124	denotes	Slc39a10
T7332	23645-23649	SO:0000704	denotes	gene
T7333	23714-23723	SO:0000993	denotes	consensus
T7334	23764-23769	NCBITaxon:10088	denotes	mouse
T7335	23770-23778	PR:000015124	denotes	Slc39a10
T7336	23810-23812	SO:0000028	denotes	bp
T7337	23858-23860	SO:0000028	denotes	bp
T7338	23894-23899	PR:000010717	denotes	MTF-1
T7339	23944-23949	UBERON:0002107	denotes	liver
T7340	23974-23978	PR:000010717	denotes	Mtf1
T7341	23978-23982	SO:0000346	denotes	loxP
T7342	23999-24003	PR:000010717	denotes	Mtf1
T7343	24003-24005	PR:000010788	denotes	Mx
T7344	24010-24015	NCBITaxon:10088	denotes	mouse
T7897	24091-24096	PR:000010717	denotes	MTF-1
T7898	24109-24114	SO:0000704	denotes	genes
T7899	24174-24179	SO:0000704	denotes	genes
T7900	24205-24210	PR:000010717	denotes	MTF-1
T7901	24278-24282	NCBITaxon:10088	denotes	mice
T7902	24317-24321	NCBITaxon:10088	denotes	mice
T7903	24503-24508	SO:0000704	denotes	genes
T7904	24573-24578	SO:0000704	denotes	genes
T7905	24649-24654	SO:0000704	denotes	genes
T7906	24671-24684	_FRAGMENT	denotes	metabolism of
T7907	24701-24712	GO:0006749	denotes	glutathione
T7908	24701-24712	CHEBI:16856	denotes	glutathione
T7909	24774-24779	SO:0000704	denotes	genes
T7910	24793-24839	PR:000007897	denotes	catalytic subunit of glutamate-cysteine ligase
T7911	24841-24845	PR:000007897	denotes	Gclc
T7912	24891-24915	GO:0006750	denotes	synthesis of glutathione
T7913	24904-24915	CHEBI:16856	denotes	glutathione
T7914	24922-24933	CHEBI:16856	denotes	glutathione
T7915	24922-24945	PR:000008292	denotes	glutathione reductase 1
T7916	24957-24965	MOP:0000569	denotes	reducing
T7917	24977-24985	MOP:0000568	denotes	oxidized
T7918	24977-24997	CHEBI:17858	denotes	oxidized glutathione
T7919	25008-25019	CHEBI:16856	denotes	glutathione
T7920	25008-25039	PR:000030257	denotes	glutathione-S-transferase, mu 4
T7921	25041-25046	PR:000030257	denotes	Gstm4
T7922	25074-25085	CHEBI:16856	denotes	glutathione
T7923	25120-25134	GO:0098754	denotes	detoxification
T7924	25242-25246	PR:000007897	denotes	Gclc
T7925	25268-25324	PR:000007897	denotes	heavy chain subunit of gamma-glutamylcysteine synthetase
T7926	25291-25313	CHEBI:24195	denotes	gamma-glutamylcysteine
T7927	25326-25333	PR:000007897	denotes	Ggcs-hc
T7928	25378-25382	SO:0000704	denotes	gene
T7929	25386-25391	PR:000010717	denotes	MTF-1
T7930	25401-25411	GO:0010467	denotes	expression
T7931	25431-25435	PR:000007897	denotes	Gclc
T7932	25479-25484	UBERON:0007023	denotes	adult
T7933	25485-25490	NCBITaxon:10088	denotes	mouse
T7934	25491-25496	UBERON:0002107	denotes	liver
T7935	25515-25520	PR:000010717	denotes	MTF-1
T7936	25549-25560	CHEBI:16856	denotes	glutathione
T7937	25575-25583	_FRAGMENT	denotes	cellular
T7938	25592-25600	GO:0051716	denotes	response
T7939	25602-25607	NCBITaxon:10088	denotes	mouse
T7940	25608-25617	UBERON:0000922	denotes	embryonic
T7941	25618-25629	CL:0000057	denotes	fibroblasts
T7942	25658-25662	PR:000010717	denotes	Mtf1
T7943	25709-25712	CHEBI:28714	denotes	BSO
T7944	25725-25763	CHEBI:75599	denotes	inhibitor of glutamate-cysteine ligase
T7945	25839-25850	CHEBI:78021	denotes	tetrazolium
T7946	25851-25855	CHEBI:24866	denotes	salt
T7947	25856-25859	CHEBI:53233	denotes	MTT
T7948	25901-25904	CHEBI:28714	denotes	BSO
T7949	26001-26004	CHEBI:28714	denotes	BSO
T7950	26097-26101	PR:000010717	denotes	Mtf1
T7951	26134-26145	CHEBI:16856	denotes	glutathione
T7952	26170-26174	PR:000010717	denotes	Mtf1
T7953	26208-26215	GO:0006952	denotes	defense
T7954	26232-26243	CHEBI:16856	denotes	glutathione
T7955	26262-26267	PR:000010717	denotes	MTF-1
T7956	26283-26288	SO:0000704	denotes	genes
T7957	26362-26367	SO:0000704	denotes	genes
T7958	26383-26394	CHEBI:16856	denotes	glutathione
T7959	26433-26438	SO:0000704	denotes	genes
T7960	26489-26494	SO:0000704	denotes	genes
T7961	26499-26522	PR:000016871	denotes	thioredoxin reductase 1
T7962	26524-26530	PR:000016871	denotes	Txnrd1
T7963	26544-26552	MOP:0000569	denotes	reducing
T7964	26598-26653	PR:000009274	denotes	KDEL endoplasmic reticulum protein retention receptor 2
T7965	26603-26624	GO:0005783	denotes	endoplasmic reticulum
T7966	26603-26642	GO:0035437	denotes	endoplasmic reticulum protein retention
T7967	26655-26661	PR:000009274	denotes	Kdelr2
T7968	26680-26682	GO:0005783	denotes	ER
T7969	26728-26756	PR:000004621	denotes	Bcl2-associated athanogene 3
T7970	26758-26762	PR:000004621	denotes	Bag3
T7971	26791-26800	GO:0006915	denotes	apoptosis
T9035	26867-26871	PR:000010717	denotes	Mtf1
T9036	26879-26884	UBERON:0002107	denotes	liver
T9037	26888-26893	UBERON:0007023	denotes	adult
T9038	26895-26897	CHEBI:76777	denotes	pI
T9039	26909-26913	PR:000010717	denotes	Mtf1
T9040	26913-26915	PR:000010788	denotes	Mx
T9041	26920-26924	NCBITaxon:10088	denotes	mice
T9042	26983-26987	NCBITaxon:10088	denotes	mice
T9043	27033-27038	PR:000010717	denotes	MTF-1
T9044	27061-27066	UBERON:0007023	denotes	adult
T9045	27067-27072	UBERON:0002107	denotes	liver
T9046	27116-27125	UBERON:0000922	denotes	embryonic
T9047	27116-27125	_FRAGMENT	denotes	embryonic
T9048	27132-27143	GO:0009790	denotes	development
T9049	27126-27131	UBERON:0002107	denotes	liver
T9050	27126-27143	GO:0001889	denotes	liver development
T9051	27168-27172	SO:0000704	denotes	gene
T9052	27168-27183	GO:0010467	denotes	gene expression
T9053	27187-27193	UBERON:0002107	denotes	livers
T9054	27222-27226	PR:000010717	denotes	Mtf1
T9055	27226-27228	PR:000010788	denotes	Mx
T9056	27237-27241	PR:000010717	denotes	Mtf1
T9057	27241-27245	SO:0000346	denotes	loxP
T9058	27246-27250	NCBITaxon:10088	denotes	mice
T9059	27268-27273	PR:000010717	denotes	MTF-1
T9060	27281-27285	SO:0000704	denotes	gene
T9061	27298-27309	SO:0000673	denotes	Transcripts
T9062	27355-27360	SO:0000704	denotes	genes
T9063	27361-27364	PR:000010925	denotes	Mt1
T9064	27369-27372	PR:000010704	denotes	Mt2
T9065	27428-27433	PR:000010717	denotes	MTF-1
T9066	27467-27477	GO:0010467	denotes	expression
T9067	27535-27540	SO:0000704	denotes	genes
T9068	27544-27549	PR:000014662	denotes	Sepw1
T9069	27583-27588	PR:000014662	denotes	SEPW1
T9070	27688-27699	CHEBI:16856	denotes	glutathione
T9071	27739-27749	GO:0010467	denotes	expression
T9072	27753-27758	NCBITaxon:10088	denotes	mouse
T9073	27759-27764	PR:000014662	denotes	Sepw1
T9074	27792-27809	CHEBI:16240	denotes	hydrogen peroxide
T9075	27858-27869	CHEBI:16856	denotes	glutathione
T9076	27922-27932	GO:0010467	denotes	expression
T9077	27947-27951	SO:0000704	denotes	gene
T9078	27963-27966	NCBITaxon:10114	denotes	rat
T9079	27967-27972	PR:000014662	denotes	Sepw1
T9080	27973-27981	SO:0000167	denotes	promoter
T9081	28009-28012	NCBITaxon:10114	denotes	rat
T9082	28013-28024	CL:0000125	denotes	glial cells
T9083	28154-28157	NCBITaxon:10114	denotes	rat
T9084	28158-28163	PR:000014662	denotes	Sepw1
T9085	28240-28245	PR:000010717	denotes	MTF-1
T9086	28281-28291	GO:0010467	denotes	expression
T9087	28338-28343	PR:000010717	denotes	MTF-1
T9088	28371-28381	GO:0010467	denotes	expression
T9089	28385-28390	NCBITaxon:10088	denotes	mouse
T9090	28391-28396	PR:000014662	denotes	Sepw1
T9091	28464-28469	PR:000011059	denotes	Ndrg1
T9092	28491-28496	PR:000010717	denotes	MTF-1
T9093	28504-28508	SO:0000704	denotes	gene
T9094	28519-28552	PR:000011059	denotes	N-myc downstream regulated gene 1
T9095	28536-28545	GO:0065007	denotes	regulated
T9096	28546-28550	SO:0000704	denotes	gene
T9097	28607-28612	PR:000010812	denotes	N-myc
T9098	28627-28637	GO:0010467	denotes	expression
T9099	28641-28646	NCBITaxon:10088	denotes	mouse
T9100	28647-28652	PR:000011059	denotes	Ndrg1
T9101	28676-28681	PR:000011059	denotes	Ndrg1
T9102	28693-28698	NCBITaxon:9606	denotes	human
T9103	28699-28707	SO:0000855	denotes	ortholog
T9104	28782-28791	CHEBI:50113	denotes	androgens
T9105	28800-28809	CHEBI:36357	denotes	compounds
T9106	28881-28890	GO:0010467	denotes	expressed
T9107	28894-28899	NCBITaxon:9606	denotes	human
T9108	28916-28923	UBERON:0000479	denotes	tissues
T9109	28933-28937	UBERON:0002048	denotes	lung
T9110	28939-28944	UBERON:0002107	denotes	liver
T9111	28946-28951	UBERON:0000955	denotes	brain
T9112	28953-28959	UBERON:0000310	denotes	breast
T9113	28961-28967	UBERON:0002113	denotes	kidney
T9114	28992-28997	PR:000011059	denotes	Ndrg1
T9115	29017-29022	NCBITaxon:9606	denotes	human
T9116	29023-29031	SO:0000855	denotes	ortholog
T9117	29186-29190	_FRAGMENT	denotes	cell
T9118	29198-29206	GO:0051716	denotes	response
T9119	29261-29266	PR:000011059	denotes	Ndrg1
T9120	29267-29271	SO:0000704	denotes	gene
T9121	29267-29282	GO:0010467	denotes	gene expression
T9122	29320-29325	PR:000010717	denotes	MTF-1
T9123	29381-29386	PR:000005958	denotes	Csrp1
T9124	29388-29398	GO:0010467	denotes	expression
T9125	29446-29451	PR:000010717	denotes	MTF-1
T9126	29557-29562	NCBITaxon:9606	denotes	human
T9127	29564-29569	NCBITaxon:8782	denotes	avian
T9128	29574-29581	NCBITaxon:9031	denotes	chicken
T9129	29582-29587	PR:000005958	denotes	CSRP1
T9130	29633-29649	GO:0070161	denotes	adhesion plaques
T9131	29674-29691	GO:0031941	denotes	filamentous actin
T9132	29716-29731	GO:0070161	denotes	adhesion plaque
T9133	29740-29745	PR:000018242	denotes	zyxin
T9134	29762-29781	GO:0051764	denotes	actin-cross-linking
T9135	29867-29879	GO:0005856	denotes	cytoskeletal
T9136	29911-29925	CL:0000010	denotes	cultured cells
T9137	29963-29987	_FRAGMENT	denotes	destruction of, cellular
T9138	29996-30004	GO:0044257	denotes	proteins
T9139	30013-30031	GO:0015629	denotes	actin cytoskeleton
T9140	30074-30077	NCBITaxon:10114	denotes	rat
T9141	30078-30084	UBERON:0002113	denotes	kidney
T9142	30118-30132	GO:0051017	denotes	actin-bundling
T9143	30141-30147	PR:000017296	denotes	villin
T9144	30215-30231	MOP:0000630	denotes	depolymerization
T9145	30215-30247	GO:0007019	denotes	depolymerization of microtubules
T9146	30235-30247	GO:0005874	denotes	microtubules
T9147	30268-30273	PR:000005958	denotes	CSRP1
T9148	30311-30332	GO:0044430	denotes	cytoskeletal elements
T9149	30340-30345	NCBITaxon:10088	denotes	mouse
T9150	30393-30401	NCBITaxon:1	denotes	organism
T9151	30421-30433	GO:0005856	denotes	cytoskeleton
T9152	30477-30482	PR:000010717	denotes	MTF-1
T9153	30507-30517	GO:0010467	denotes	expression
T9154	30544-30549	PR:000010717	denotes	MTF-1
T9155	30583-30591	PR:000015124	denotes	Slc39a10
T9156	30638-30648	GO:0010467	denotes	expression
T9157	30665-30670	SO:0000704	denotes	genes
T9158	30676-30679	PR:000010925	denotes	Mt1
T9159	30681-30684	PR:000010704	denotes	Mt2
T9160	30690-30694	PR:000015073	denotes	Znt1
T9161	30703-30711	PR:000015124	denotes	SLC39A10
T9162	30725-30730	NCBITaxon:10088	denotes	mouse
T9163	30786-30789	CHEBI:24870	denotes	ion
T9164	30872-30885	GO:0005622	denotes	intracellular
T9165	30886-30897	GO:0005737	denotes	cytoplasmic
T9166	30904-30907	CHEBI:24870	denotes	ion
T9167	30936-30949	GO:0005576	denotes	extracellular
T9168	30936-30949	_FRAGMENT	denotes	extracellular
T9169	30968-30977	GO:0006858	denotes	transport
T9170	30954-30963	GO:0031982	denotes	vesicular
T9171	30954-30963	_FRAGMENT	denotes	vesicular
T9172	30968-30977	GO:0016192	denotes	transport
T9173	30964-30967	CHEBI:24870	denotes	ion
T9174	30964-30977	GO:0006811	denotes	ion transport
T9175	30987-30996	GO:0005737	denotes	cytoplasm
T9176	31110-31118	PR:000015124	denotes	SLC39A10
T9177	31255-31260	PR:000010717	denotes	MTF-1
T9178	31289-31299	GO:0010467	denotes	expression
T9179	31327-31332	NCBITaxon:10088	denotes	mouse
T9180	31333-31337	PR:000015073	denotes	Znt1
T9181	31338-31342	SO:0000704	denotes	gene
T9182	31419-31432	GO:0005622	denotes	intracellular
T9183	31433-31444	GO:0005737	denotes	cytoplasmic
T9184	31494-31507	GO:0005622	denotes	intracellular
T9185	31508-31516	GO:0031982	denotes	vesicles
T9186	31616-31624	_FRAGMENT	denotes	cellular
T9187	31630-31641	GO:0019725	denotes	homeostasis
T9188	31662-31670	PR:000015124	denotes	SLC39A10
T9189	31701-31706	PR:000010717	denotes	MTF-1
T9190	31713-31720	GO:0065007	denotes	control
T9191	31721-31731	GO:0010467	denotes	expression
T9192	31794-31798	PR:000015073	denotes	Znt1
T9193	31803-31811	PR:000015124	denotes	Slc39a10
T9194	31833-31838	PR:000010717	denotes	MTF-1
T9195	31894-31902	PR:000015124	denotes	Slc39a10
T9196	32004-32030	SO:0000315	denotes	transcriptional start site
T9197	32139-32143	SO:0000704	denotes	gene
T9198	32206-32241	PR:P47043	denotes	zinc-responsive activator protein 1
T9199	32243-32247	PR:P47043	denotes	Zap1
T9200	32264-32268	SO:0000704	denotes	gene
T9201	32270-32298	PR:Q12436	denotes	zinc-regulated transporter 2
T9202	32275-32284	GO:0065007	denotes	regulated
T9203	32300-32304	PR:Q12436	denotes	ZRT2
T9204	32339-32347	PR:000015124	denotes	Slc39a10
T9205	32348-32358	GO:0010467	denotes	expression
T9206	32362-32367	PR:000010717	denotes	MTF-1
T9207	32416-32424	SO:0000167	denotes	promoter
T9208	32449-32454	PR:000010717	denotes	MTF-1
T9209	32506-32514	PR:000015124	denotes	Slc39a10
T9210	32515-32526	SO:0000673	denotes	transcripts
T9211	32608-32612	SO:0000704	denotes	gene
T9212	32624-32629	PR:000010717	denotes	MTF-1
T9213	32635-32640	NCBITaxon:10088	denotes	mouse
T9214	32641-32648	UBERON:0000922	denotes	embryos
T9215	32665-32669	PR:000010717	denotes	Mtf1
T9216	32723-32728	SO:0000704	denotes	genes
T9217	32750-32767	PR:000003809	denotes	alpha-fetoprotein
T9218	32769-32772	PR:000003809	denotes	Afp
T9219	32782-32787	UBERON:0002107	denotes	liver
T9220	32818-32823	SO:0000172	denotes	CCAAT
T9221	32818-32854	PR:000005307	denotes	CCAAT/enhancer binding protein alpha
T9222	32824-32832	SO:0000165	denotes	enhancer
T9223	32856-32861	PR:000005307	denotes	Cebpa
T9224	32917-32930	GO:0001889	denotes	hepatogenesis
T9225	32932-32935	PR:000003809	denotes	Afp
T9226	32936-32946	GO:0010467	denotes	expression
T9227	32964-32971	GO:0007567	denotes	natally
T9228	32988-32995	PR:000003918	denotes	albumin
T9229	33012-33017	UBERON:0007023	denotes	adult
T9230	33018-33022	PR:000010717	denotes	Mtf1
T9231	33022-33024	PR:000010788	denotes	Mx
T9232	33029-33033	NCBITaxon:10088	denotes	mice
T9233	33042-33047	PR:000010717	denotes	MTF-1
T9234	33077-33080	PR:000003809	denotes	Afp
T9235	33081-33091	GO:0010467	denotes	expression
T9236	33093-33098	PR:000005307	denotes	Cebpa
T9237	33102-33111	GO:0010467	denotes	expressed
T9238	33119-33124	UBERON:0007023	denotes	adult
T9239	33125-33130	UBERON:0002107	denotes	liver
T9240	33151-33158	UBERON:0000479	denotes	tissues
T9241	33221-33231	GO:0010467	denotes	expression
T9242	33247-33253	UBERON:0002107	denotes	livers
T9243	33259-33264	UBERON:0007023	denotes	adult
T9244	33265-33269	PR:000010717	denotes	Mtf1
T9245	33269-33273	SO:0000346	denotes	loxP
T9246	33278-33282	PR:000010717	denotes	Mtf1
T9247	33282-33284	PR:000010788	denotes	Mx
T9248	33289-33293	NCBITaxon:10088	denotes	mice
T9249	33323-33328	PR:000010717	denotes	MTF-1
T9250	33340-33345	PR:000005307	denotes	Cebpa
T9251	33346-33356	GO:0010467	denotes	expression
T9252	33369-33378	UBERON:0000922	denotes	embryonal
T9253	33369-33390	GO:0009790	denotes	embryonal development
T9254	33500-33505	PR:000010717	denotes	MTF-1
T9255	33612-33617	SO:0000704	denotes	genes
T9256	33621-33626	PR:000010717	denotes	MTF-1
T9257	33634-33639	UBERON:0007023	denotes	adult
T9258	33640-33645	NCBITaxon:10088	denotes	mouse
T9259	33646-33651	UBERON:0002107	denotes	liver
T9260	33668-33673	PR:000014662	denotes	Sepw1
T9261	33675-33680	PR:000010717	denotes	MTF-1
T9262	33711-33721	GO:0010467	denotes	expression
T9263	33744-33749	NCBITaxon:10088	denotes	mouse
T9264	33750-33755	PR:000010717	denotes	MTF-1
T9265	33759-33768	MOP:0000568	denotes	oxidative
T9266	33799-33804	PR:000010717	denotes	MTF-1
T9267	33840-33850	GO:0010467	denotes	expression
T9268	33854-33859	PR:000011059	denotes	Ndrg1
T9269	33864-33869	PR:000005958	denotes	Csrp1
T9270	33884-33889	PR:000010717	denotes	MTF-1
T9271	33917-33927	GO:0010467	denotes	expression
T9272	33931-33939	PR:000015124	denotes	Slc39a10
T9273	33998-34003	SO:0000704	denotes	genes
T9274	34009-34012	PR:000010925	denotes	Mt1
T9275	34014-34017	PR:000010704	denotes	Mt2
T9276	34021-34025	PR:000015073	denotes	Znt1
T9277	34134-34138	SO:0000704	denotes	gene
T9278	34158-34163	UBERON:0002107	denotes	liver
T9279	34164-34168	SO:0000704	denotes	gene
T9280	34164-34179	GO:0010467	denotes	gene expression
T9281	34209-34213	NCBITaxon:10088	denotes	mice
T9282	34240-34245	SO:0000704	denotes	genes
T9283	34330-34335	PR:000010717	denotes	MTF-1
T9284	34364-34401	GO:1903409	denotes	production of reactive oxygen species
T9285	34378-34401	CHEBI:26523	denotes	reactive oxygen species
T9286	34471-34485	CL:0000010	denotes	cultured cells
T9287	34489-34496	NCBITaxon:33208	denotes	animals
T9288	34540-34547	MOP:0000569	denotes	reduced
T9289	34540-34559	CHEBI:16856	denotes	reduced glutathione
T9290	34561-34566	CHEBI:18059	denotes	lipid
T9291	34604-34613	MOP:0000568	denotes	Oxidative
T9292	34655-34675	GO:0019725	denotes	cellular homeostasis
T9293	34706-34716	GO:0010467	denotes	expression
T9294	34720-34725	SO:0000704	denotes	genes
T9295	34735-34746	GO:0006953	denotes	acute-phase
T9296	34789-34796	NCBITaxon:40674	denotes	mammals
T9297	34833-34839	UBERON:0002113	denotes	kidney
T9298	34844-34849	UBERON:0002107	denotes	liver
T9299	34879-34886	GO:0032991	denotes	complex
T9300	34989-34998	MOP:0000568	denotes	oxidative
T9301	35047-35058	CHEBI:16856	denotes	glutathione
T9302	35093-35100	GO:0006952	denotes	defense
T9303	35132-35143	CHEBI:16856	denotes	Glutathione
T9304	35156-35165	GO:0065003	denotes	complexes
T9305	35193-35206	CHEBI:26519	denotes	free radicals
T9306	35217-35240	CHEBI:26523	denotes	reactive oxygen species
T9307	35315-35326	CHEBI:16856	denotes	glutathione
T9308	35330-35338	MOP:0000568	denotes	oxidized
T9309	35368-35379	CHEBI:16856	denotes	glutathione
T9310	35397-35408	CHEBI:16856	denotes	glutathione
T9311	35436-35447	MOP:0000779	denotes	conjugation
T9312	35476-35487	CHEBI:16856	denotes	glutathione
T9313	35534-35538	PR:000007897	denotes	Gclc
T9314	35548-35553	PR:000030257	denotes	Gstm4
T9315	35581-35592	CHEBI:16856	denotes	glutathione
T9316	35600-35608	_FRAGMENT	denotes	cellular
T9317	35617-35625	GO:0051716	denotes	response
T9318	35690-35695	NCBITaxon:10088	denotes	mouse
T9319	35696-35705	UBERON:0000922	denotes	embryonic
T9320	35706-35717	CL:0000057	denotes	fibroblasts
T9321	35740-35744	PR:000010717	denotes	Mtf1
T9322	35771-35782	CHEBI:16856	denotes	glutathione
T9323	35822-35827	PR:000010717	denotes	MTF-1
T9324	35843-35848	SO:0000704	denotes	genes
T9325	35860-35867	MOP:0000569	denotes	reduced
T9326	35860-35879	CHEBI:16856	denotes	reduced glutathione
T9327	35910-35917	GO:0006952	denotes	defense
T9328	35981-35989	_FRAGMENT	denotes	cellular
T9329	36003-36010	GO:0006968	denotes	defense
T9330	36020-36025	PR:000010717	denotes	MTF-1
T9331	36041-36046	SO:0000704	denotes	genes
T9332	36088-36099	CHEBI:16856	denotes	glutathione
T9333	36129-36134	PR:000014662	denotes	Sepw1
T2356	5035-5041	NCBITaxon:33208	denotes	Animal
T2357	5076-5080	PR:000010717	denotes	Mtf1
T2358	5080-5084	SO:0000346	denotes	loxP
T2359	5085-5089	SO:0000346	denotes	loxP
T2360	5090-5094	NCBITaxon:10088	denotes	mice
T2361	5109-5111	PR:000010788	denotes	Mx
T2362	5116-5125	SO:0000902	denotes	transgene
T2363	5127-5131	PR:000010717	denotes	Mtf1
T2364	5131-5135	SO:0000346	denotes	loxP
T2365	5136-5140	SO:0000346	denotes	loxP
T2366	5141-5143	PR:000010788	denotes	Mx
T2367	5156-5160	PR:000010717	denotes	Mtf1
T2368	5160-5162	PR:000010788	denotes	Mx
T2369	5200-5209	SO:0000902	denotes	transgene
T2370	5211-5215	PR:000010717	denotes	Mtf1
T3103	8084-8091	SO:0000112	denotes	primers
T3104	8093-8098	PR:000005958	denotes	Csrp1
T3105	8158-8169	CHEBI:17368	denotes	hypoxanthin
T3106	8269-8273	PR:000010717	denotes	Mtf1
T3107	8339-8344	PR:000011059	denotes	Ndrg1
T3108	8404-8409	PR:000014662	denotes	Sepw1
T3109	8469-8477	PR:000015124	denotes	Slc39a10
T3222	8538-8549	PR:000025471	denotes	S1 nuclease
T3223	8561-8572	SO:0000673	denotes	transcripts
T3224	8574-8576	PR:000025471	denotes	S1
T3225	8587-8589	PR:000025471	denotes	S1
T3226	8791-8793	PR:000025471	denotes	S1
T3227	8831-8834	CHEBI:37972	denotes	32P
T3228	8866-8868	PR:000025471	denotes	S1
T3229	8950-8955	PR:000014662	denotes	Sepw1
T3230	8956-8958	PR:000025471	denotes	S1
T4430	12662-12668	UBERON:0000479	denotes	tissue
T4431	12802-12832	CHEBI:28714	denotes	l-buthionine-[S,R]-sulfoximine
T4432	12834-12837	CHEBI:28714	denotes	BSO
T4433	12850-12854	CHEBI:23888	denotes	drug
T4434	12869-12880	CHEBI:16856	denotes	glutathione
T4435	12869-12890	GO:0006750	denotes	glutathione synthesis
T4436	12944-12949	CHEBI:35456	denotes	CdCl2
T4437	13048-13051	CHEBI:53233	denotes	MTT
T4438	13053-13113	CHEBI:53233	denotes	3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromid
T4439	13121-13139	GO:0008283	denotes	Cell Proliferation
R5552	T9187	T9186	_lexicallyChainedTo	homeostasis,cellular
R5553	T9317	T9316	_lexicallyChainedTo	response,cellular
R5554	T9329	T9328	_lexicallyChainedTo	defense,cellular
R1485	T2378	T2377	_lexicallyChainedTo	acid,polyinosinic
R2087	T3295	T3294	_lexicallyChainedTo	sequence,synthetic
R2793	T4169	T4168	_lexicallyChainedTo	cell,embryonic
R2937	T4531	T4530	_lexicallyChainedTo	beta,interferon
R4704	T7309	T7308	_lexicallyChainedTo	expression,downregulation of
R5029	T7907	T7906	_lexicallyChainedTo	glutathione,metabolism of
R5030	T7938	T7937	_lexicallyChainedTo	response,cellular
R5547	T9048	T9047	_lexicallyChainedTo	development,embryonic
R5548	T9118	T9117	_lexicallyChainedTo	response,cell
R5549	T9138	T9137	_lexicallyChainedTo	proteins,"destruction of, cellular"
R5550	T9169	T9168	_lexicallyChainedTo	transport,extracellular
R5551	T9172	T9171	_lexicallyChainedTo	transport,vesicular

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T815	17-26	NCBITaxon:1	denotes	organisms
T816	115-123	GO_EXT:reaction_or_response	denotes	response
T817	146-152	CHEBI_EXT:metal	denotes	metals
T818	162-166	CHEBI_EXT:zinc	denotes	zinc
T819	168-174	CHEBI_EXT:copper	denotes	copper
T820	179-186	CHEBI_EXT:cadmium	denotes	cadmium
T821	215-219	CHEBI_EXT:zinc	denotes	zinc
T822	221-227	CHEBI_EXT:copper	denotes	copper
T823	232-239	CHEBI_EXT:cadmium	denotes	cadmium
T824	269-273	CHEBI:29105	denotes	Zn2+
T825	275-279	CHEBI:29036	denotes	Cu2+
T826	284-288	CHEBI:48775	denotes	Cd2+
T827	336-344	CHEBI_SO_EXT:cysteine	denotes	cysteine
T828	350-358	CHEBI_PR_EXT:protein	denotes	proteins
T829	386-391	CHEBI_EXT:metal	denotes	metal
T830	392-403	GO:0042592	denotes	homeostasis
T831	408-422	GO:0098754	denotes	detoxification
T832	447-451	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T833	468-473	CHEBI_EXT:metal	denotes	metal
T834	474-478	CHEBI:24870	denotes	ions
T835	493-498	NCBITaxon:10088	denotes	mouse
T836	531-536	SO_EXT:0000704	denotes	genes
T837	552-555	PR_EXT:000010925	denotes	Mt1
T838	559-562	PR_EXT:000010706	denotes	Mt4
T839	588-593	CHEBI_EXT:metal	denotes	metal
T840	603-613	GO:0010467	denotes	expression
T841	617-620	PR_EXT:000010925	denotes	Mt1
T842	625-628	PR_EXT:000010704	denotes	Mt2
T843	644-649	CHEBI_EXT:metal	denotes	metal
T844	644-683	PR_EXT:000010717	denotes	metal-responsive transcription factor 1
T845	661-674	GO_EXT:transcription	denotes	transcription
T846	661-681	GO_EXT:transcription_factor	denotes	transcription factor
T847	685-690	PR_EXT:000010717	denotes	MTF-1
T848	704-708	CHEBI_EXT:zinc	denotes	zinc
T849	716-723	CHEBI_PR_EXT:protein	denotes	protein
T850	752-755	CHEBI_SO_EXT:DNA	denotes	DNA
T851	756-765	SO_EXT:biological_sequence	denotes	sequences
T852	774-779	CHEBI_EXT:metal	denotes	metal
T853	780-788	GO_EXT:reaction_or_response	denotes	response
T854	810-819	SO:0000993	denotes	consensus
T855	820-828	SO_EXT:biological_sequence	denotes	sequence
T856	864-873	SO_EXT:0000167	denotes	promoters
T857	884-889	SO_EXT:0000704	denotes	genes
T858	897-902	PR_EXT:000010717	denotes	MTF-1
T859	906-915	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T860	934-942	SO_EXT:0000853	denotes	homologs
T861	974-979	NCBITaxon:10088	denotes	mouse
T862	986-992	NCBITaxon:9606	denotes	humans
T863	999-1009	NCBITaxon:7215	denotes	Drosophila
T864	1022-1026	NCBITaxon_EXT:fish	denotes	fish
T865	1048-1053	PR_EXT:000010717	denotes	MTF-1
T866	1095-1100	NCBITaxon:10088	denotes	mouse
T867	1128-1133	CHEBI_EXT:metal	denotes	metal
T868	1140-1145	PR_EXT:000010717	denotes	MTF-1
T869	1183-1188	SO_EXT:0000704	denotes	genes
T870	1192-1200	GO_EXT:reaction_or_response	denotes	response
T871	1237-1246	MOP:0000568	denotes	oxidative
T872	1336-1340	PR_EXT:000015073	denotes	Znt1
T873	1342-1350	SO_EXT:sequence_coding_function	denotes	encoding
T874	1361-1376	GO:0005886	denotes	plasma membrane
T875	1377-1386	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T876	1387-1391	CHEBI_EXT:zinc	denotes	zinc
T877	1392-1410	GO_EXT:0015562	denotes	efflux transporter
T878	1399-1410	GO_EXT:biological_mover_or_transporter	denotes	transporter
T879	1453-1457	SO_EXT:0000704	denotes	gene
T880	1462-1471	UBERON:0001987	denotes	placental
T881	1462-1485	PR_EXT:000012605	denotes	placental growth factor
T882	1472-1478	GO_EXT:biological_growth_entity_or_process	denotes	growth
T883	1472-1485	GO_EXT:0008083	denotes	growth factor
T884	1487-1491	PR_EXT:000012605	denotes	Plgf
T885	1497-1507	GO:0001525	denotes	angiogenic
T886	1508-1515	CHEBI_PR_EXT:protein	denotes	protein
T887	1523-1531	UBERON_EXT:vascular_system_or_vasculature_or_vessel	denotes	vascular
T888	1523-1557	PR_EXT:vascuar_endothelial_growth_factor	denotes	vascular endothelial growth factor
T889	1532-1543	UBERON:0001986	denotes	endothelial
T890	1544-1550	GO_EXT:biological_growth_entity_or_process	denotes	growth
T891	1544-1557	GO_EXT:0008083	denotes	growth factor
T892	1559-1563	PR_EXT:vascuar_endothelial_growth_factor	denotes	VEGF
T893	1651-1656	PR_EXT:000010717	denotes	MTF-1
T894	1690-1703	GO:0009790	denotes	embryogenesis
T895	1728-1732	PR_EXT:000010717	denotes	Mtf1
T896	1744-1753	UBERON:0000922	denotes	embryonic
T897	1754-1763	GO_EXT:fatality_or_lethality	denotes	lethality
T898	1784-1790	GO:0007620	denotes	coitum
T899	1798-1808	CL:0000182	denotes	hepatocyte
T900	1809-1817	GO_PATO_EXT:necrosis	denotes	necrosis
T901	1837-1841	NCBITaxon:10088	denotes	mice
T902	1847-1851	SO_EXT:sequence_nullness	denotes	null
T903	1852-1861	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T904	1903-1908	SO_EXT:0000704	denotes	genes
T905	1910-1913	PR_EXT:000010925	denotes	Mt1
T906	1918-1921	PR_EXT:000010704	denotes	Mt2
T907	1955-1962	CHEBI_EXT:cadmium	denotes	cadmium
T908	2009-2014	PR_EXT:000010717	denotes	MTF-1
T909	2022-2027	SO_EXT:0000704	denotes	genes
T910	2048-2054	GO_EXT:fatality_or_lethality	denotes	lethal
T911	2079-2083	SO_EXT:0000346	denotes	loxP
T912	2149-2158	UBERON:0000922	denotes	embryonic
T913	2159-2165	GO_EXT:fatality_or_lethality	denotes	lethal
T914	2192-2196	PR_EXT:000010717	denotes	Mtf1
T915	2206-2210	NCBITaxon:10088	denotes	mice
T916	2267-2275	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T917	2279-2283	PR_EXT:000010717	denotes	Mtf1
T918	2293-2298	UBERON:0002107	denotes	liver
T919	2305-2310	GO:0007567	denotes	birth
T920	2324-2330	GO_EXT:fatality_or_lethality	denotes	lethal
T921	2395-2400	UBERON:0002107	denotes	liver
T922	2410-2414	PR_EXT:000010717	denotes	Mtf1
T923	2424-2429	NCBITaxon:10088	denotes	mouse
T924	2473-2478	PR_EXT:000010717	denotes	MTF-1
T925	2486-2491	SO_EXT:0000704	denotes	genes
T926	2496-2503	CHEBI_EXT:cadmium	denotes	cadmium
T927	2514-2519	SO_EXT:0000704	denotes	genes
T928	2527-2532	UBERON:0007023	denotes	adult
T929	2533-2538	UBERON:0002107	denotes	liver
T930	2559-2563	SO_EXT:0000704	denotes	gene
T931	2626-2633	CHEBI_EXT:cadmium	denotes	cadmium
T932	2642-2646	PR_EXT:000010717	denotes	Mtf1
T933	2668-2672	NCBITaxon:10088	denotes	mice
T934	2753-2755	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T935	2806-2811	SO_EXT:0000704	denotes	genes
T936	2846-2851	SO_EXT:0000704	denotes	genes
T937	2855-2860	PR_EXT:000010717	denotes	MTF-1
T938	2875-2880	PR_EXT:000010717	denotes	MTF-1
T939	2904-2909	UBERON:0002107	denotes	liver
T940	2910-2920	GO:0010467	denotes	expression
T941	2928-2932	SO_EXT:0000704	denotes	gene
T942	2937-2950	CHEBI_EXT:selenoprotein	denotes	selenoprotein
T943	2937-2962	PR_EXT:000014662	denotes	selenoprotein W, muscle 1
T944	2954-2960	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T945	2964-2969	PR_EXT:000014662	denotes	Sepw1
T946	2986-2993	CHEBI_EXT:cadmium	denotes	cadmium
T947	3002-3012	GO:0010467	denotes	expression
T948	3016-3049	PR_EXT:000011059	denotes	N-myc downstream regulated gene 1
T949	3033-3042	GO:0065007	denotes	regulated
T950	3043-3047	SO_EXT:0000704	denotes	gene
T951	3051-3056	PR_EXT:000011059	denotes	Ndrg1
T952	3066-3070	SO_EXT:0000704	denotes	gene
T953	3071-3079	SO_EXT:sequence_coding_function	denotes	encoding
T954	3080-3088	CHEBI_SO_EXT:cysteine	denotes	cysteine
T955	3080-3116	PR_EXT:000005958	denotes	cysteine- and glycine-rich protein 1
T956	3094-3101	CHEBI_SO_EXT:glycine	denotes	glycine
T957	3107-3114	CHEBI_PR_EXT:protein	denotes	protein
T958	3118-3123	PR_EXT:000005958	denotes	Csrp1
T959	3139-3144	PR_EXT:000010717	denotes	MTF-1
T960	3168-3178	GO:0010467	denotes	expression
T961	3182-3217	PR_EXT:000015124	denotes	solute carrier family 39, member 10
T962	3189-3196	GO_EXT:biological_mover_or_transporter	denotes	carrier
T963	3218-3222	SO_EXT:0000704	denotes	gene
T964	3224-3232	PR_EXT:000015124	denotes	Slc39a10
T965	3241-3248	SO_EXT:sequence_coding_function	denotes	encodes
T966	3260-3265	CHEBI_EXT:metal	denotes	metal
T967	3260-3281	GO_EXT:0046873	denotes	metal ion transporter
T968	3266-3269	CHEBI:24870	denotes	ion
T969	3270-3281	GO_EXT:biological_mover_or_transporter	denotes	transporter
T970	3289-3294	PR_EXT:000010717	denotes	MTF-1
T971	3321-3329	GO_EXT:reaction_or_response	denotes	response
T972	3339-3344	SO_EXT:0000704	denotes	genes
T973	3357-3368	CHEBI:16856	denotes	glutathione
T974	3357-3379	GO:0006749	denotes	glutathione metabolism
T975	3431-3438	CHEBI_EXT:cadmium	denotes	cadmium
T976	3439-3446	GO:0006952	denotes	defense
T977	3456-3467	CHEBI:16856	denotes	glutathione
T978	3488-3493	PR_EXT:000010717	denotes	MTF-1
T979	3509-3514	SO_EXT:0000704	denotes	genes
T2011	3582-3586	PR_EXT:000010717	denotes	Mtf1
T2012	3608-3612	NCBITaxon:10088	denotes	mice
T2013	3617-3622	UBERON:0002107	denotes	liver
T2014	3632-3640	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T2015	3641-3645	PR_EXT:000010717	denotes	Mtf1
T2016	3667-3671	NCBITaxon:10088	denotes	mice
T2017	3750-3764	SO_EXT:0000040	denotes	genomic clones
T2018	3776-3781	SO_EXT:0000147	denotes	exons
T2019	3792-3796	PR_EXT:000010717	denotes	Mtf1
T2020	3822-3826	SO_EXT:0000704	denotes	gene
T2021	3827-3843	SO_EXT:0001644	denotes	targeting vector
T2022	3859-3872	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T2024	3917-3925	SO_EXT:0005853	denotes	cassette
T2025	3927-3930	GO_EXT:phosphoglycerate_kinase	denotes	PGK
T2026	3931-3934	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	neo
T2027	3936-3943	SO:0000357	denotes	flanked
T2028	3951-3961	SO_EXT:0000346	denotes	loxP sites
T2029	3966-3972	SO_EXT:sequence_cloning_process	denotes	cloned
T2030	3998-4002	SO_EXT:0000147	denotes	exon
T2031	4008-4012	PR_EXT:000010717	denotes	Mtf1
T2032	4024-4033	SO_EXT:0000346	denotes	loxP site
T2033	4038-4044	SO_EXT:sequence_cloning_process	denotes	cloned
T2034	4070-4074	SO_EXT:0000147	denotes	exon
T2035	4080-4089	CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group	denotes	thymidine
T2036	4080-4096	GO_PR_EXT:thymidine_kinase	denotes	thymidine kinase
T2037	4098-4100	GO_PR_EXT:thymidine_kinase	denotes	TK
T2038	4102-4110	SO_EXT:0005853	denotes	cassette
T2039	4115-4123	SO_EXT:sequence_insertion_process	denotes	inserted
T2040	4147-4151	SO_EXT:0000147	denotes	exon
T2041	4159-4167	CL:0002322	denotes	ES cells
T2042	4162-4167	CL_GO_EXT:cell	denotes	cells
T2043	4197-4207	SO_EXT:sequence_linearization	denotes	linearized
T2044	4208-4224	SO_EXT:0001644	denotes	targeting vector
T2045	4254-4258	CHEBI:42768	denotes	G418
T2046	4358-4368	GO:0010467	denotes	expression
T2047	4376-4387	GO_EXT:recombinase	denotes	recombinase
T2048	4410-4413	GO_EXT:phosphoglycerate_kinase	denotes	PGK
T2049	4414-4417	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	neo
T2050	4418-4426	SO_EXT:0005853	denotes	cassette
T2051	4432-4436	NCBITaxon:10088	denotes	mice
T2052	4450-4458	SO_EXT:sequence_alteration_process	denotes	modified
T2053	4459-4463	PR_EXT:000010717	denotes	Mtf1
T2054	4463-4467	SO_EXT:0000346	denotes	loxP
T2055	4468-4474	SO_EXT:0001023	denotes	allele
T2056	4515-4521	SO_EXT:sequence_cloned_entity	denotes	clones
T2057	4535-4546	UBERON:0000358	denotes	blastocysts
T2058	4603-4610	NCBITaxon:33208	denotes	animals
T2059	4612-4616	PR_EXT:000010717	denotes	Mtf1
T2060	4616-4620	SO_EXT:0000346	denotes	loxP
T2061	4621-4625	SO_EXT:0000346	denotes	loxP
T2062	4653-4664	GO_EXT:recombinase	denotes	recombinase
T2063	4665-4675	SO_EXT:transgenic_entity	denotes	transgenic
T2064	4681-4683	PR_EXT:000010788	denotes	Mx
T2065	4745-4750	UBERON:0002107	denotes	liver
T2066	4760-4764	PR_EXT:000010717	denotes	Mtf1
T2067	4784-4788	NCBITaxon:10088	denotes	mice
T2068	4831-4838	SO_EXT:0000112	denotes	primers
T2069	4857-4868	GO_EXT:recombinase	denotes	recombinase
T2070	4935-4939	PR_EXT:000010717	denotes	Mtf1
T2071	4939-4943	SO_EXT:0000346	denotes	loxP
T2072	4947-4956	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T2073	4957-4963	SO_EXT:0001023	denotes	allele
T2405	5211-5215	PR_EXT:000010717	denotes	Mtf1
T2406	5215-5219	SO_EXT:0000346	denotes	loxP
T2407	5220-5224	SO_EXT:0000346	denotes	loxP
T2408	5233-5237	PR_EXT:000010717	denotes	Mtf1
T2409	5237-5241	SO_EXT:0000346	denotes	loxP
T2410	5262-5272	UBERON:0001179	denotes	peritoneal
T2411	5309-5328	CHEBI_SO_EXT:double_stranded_RNA	denotes	double-stranded RNA
T2412	5329-5341	_FRAGMENT	denotes	polyinosinic
T2413	5356-5360	CHEBI:76777	denotes	acid
T2414	5333-5341	CHEBI_SO_EXT:inosine	denotes	inosinic
T2415	5342-5360	CHEBI_EXT:polyC_acid	denotes	polycytidylic acid
T2416	5362-5364	CHEBI:76777	denotes	pI
T2417	5365-5367	CHEBI_EXT:polyC_acid	denotes	pC
T2418	5397-5406	CHEBI_EXT:phosphate	denotes	phosphate
T2419	5407-5415	CHEBI_CHMO_EXT:buffer_process	denotes	buffered
T2420	5416-5422	CHEBI_EXT:saline_solution	denotes	saline
T2421	5470-5473	CHEBI_SO_EXT:DNA	denotes	DNA
T2422	5474-5481	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T2423	5499-5508	SO_EXT:biological_sequence	denotes	sequences
T2424	5514-5519	PR_EXT:000010717	denotes	MTF-1
T2425	5527-5531	SO_EXT:0000704	denotes	gene
T2426	5556-5560	NCBITaxon:10088	denotes	mice
T2427	5573-5575	CHEBI:76777	denotes	pI
T2428	5576-5578	CHEBI_EXT:polyC_acid	denotes	pC
T2429	5612-5617	CHEBI_EXT:metal	denotes	metal
T2430	5629-5633	NCBITaxon:10088	denotes	mice
T2431	5665-5667	CHEBI:76777	denotes	pI
T2432	5668-5670	CHEBI_EXT:polyC_acid	denotes	pC
T2433	5686-5695	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	cutaneous
T2434	5699-5701	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	c.
T2435	5734-5738	UBERON_EXT:body	denotes	body
T2436	5746-5751	CHEBI:50292	denotes	CdSO4
T2437	5758-5763	CHEBI:50292	denotes	CdSO4
T2438	5767-5770	CHEBI:15377	denotes	H2O
T2439	5772-5779	CHEBI_EXT:cadmium	denotes	cadmium
T2440	5803-5807	UBERON_EXT:body	denotes	body
T2441	5815-5818	CHEBI:15377	denotes	H2O
T2442	5847-5858	GO_EXT:killing	denotes	sacrificing
T2485	5912-5915	CHEBI_SO_EXT:RNA	denotes	RNA
T2486	5934-5939	UBERON:0002107	denotes	liver
T2487	5940-5946	UBERON:0000479	denotes	tissue
T2488	5950-5952	CHEBI:76777	denotes	pI
T2489	5953-5955	CHEBI_EXT:polyC_acid	denotes	pC
T2490	5974-5981	CHEBI_EXT:cadmium	denotes	cadmium
T2491	5990-5994	PR_EXT:000010717	denotes	Mtf1
T2492	5994-5996	PR_EXT:000010788	denotes	Mx
T2493	6005-6009	PR_EXT:000010717	denotes	Mtf1
T2494	6009-6013	SO_EXT:0000346	denotes	loxP
T2495	6014-6018	NCBITaxon:10088	denotes	mice
T2496	6030-6038	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T2497	6069-6073	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T2498	6132-6136	SO_EXT:0000704	denotes	Gene
T2499	6132-6147	GO:0010467	denotes	Gene expression
T2500	6228-6233	NCBITaxon:10088	denotes	Mouse
T2501	6234-6240	SO_EXT:0001026	denotes	Genome
T2502	6332-6340	CHEBI_EXT:33893	denotes	reagents
T2503	6357-6361	SO_EXT:cDNA	denotes	cDNA
T2504	6396-6416	SO_EXT:double_stranded_complementary_DNA	denotes	Double-Stranded cDNA
T2505	6463-6466	CHEBI_SO_EXT:RNA	denotes	RNA
T2506	6477-6490	GO_EXT:transcription	denotes	transcription
T2507	6532-6535	CHEBI_SO_EXT:RNA	denotes	RNA
T2508	6536-6546	SO_EXT:0000673	denotes	Transcript
T2509	6547-6555	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	Labeling
T2510	6591-6595	SO_EXT:cDNA	denotes	cDNA
T2511	6614-6618	SO_EXT:cDNA	denotes	cDNA
T2512	6820-6825	CHEBI_SO_EXT:molecular_probe	denotes	probe
T2513	7021-7029	OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process	denotes	Genetics
T2514	7144-7151	CHEBI_EXT:cadmium	denotes	cadmium
T2515	7164-7169	PR_EXT:000010717	denotes	MTF-1
T2516	7182-7187	SO_EXT:0000704	denotes	genes
T2517	7189-7194	SO_EXT:0000704	denotes	Genes
T2518	7232-7241	GO:0010467	denotes	expressed
T2519	7287-7297	GO:0010467	denotes	expression
T2520	7342-7350	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T2521	7449-7453	SO_EXT:0000704	denotes	gene
T2522	7493-7497	NCBITaxon:10088	denotes	mice
T2523	7535-7539	NCBITaxon:10088	denotes	mice
T2524	7606-7615	SO:0000993	denotes	consensus
T2525	7616-7624	SO_EXT:biological_sequence	denotes	sequence
T2526	7640-7648	SO_EXT:0000167	denotes	promoter
T2527	7661-7669	SO_EXT:sequence_upstreamness	denotes	upstream
T2528	7670-7679	SO_EXT:biological_sequence	denotes	sequences
T2529	7698-7703	SO_EXT:0000704	denotes	genes
T2530	7770-7776	SO_EXT:0001026	denotes	Genome
T3110	7827-7829	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T3111	7838-7840	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T3112	7882-7884	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T3113	7965-7972	GO_PR_EXT:deoxyribonuclease_I	denotes	DNase I
T3114	7988-7991	CHEBI_SO_EXT:RNA	denotes	RNA
T3115	7993-7996	CHEBI_SO_EXT:RNA	denotes	RNA
T3116	8084-8091	SO_EXT:0000112	denotes	primers
T3117	8093-8098	PR_EXT:000005958	denotes	Csrp1
T3118	8158-8169	CHEBI:17368	denotes	hypoxanthin
T3119	8158-8202	GO_PR_EXT:hypoxanthine_guanine_phosphoribosyltransferase	denotes	hypoxanthin-guanin-phosphoribosyltransferase
T3120	8170-8176	CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group	denotes	guanin
T3121	8204-8208	GO_PR_EXT:hypoxanthine_guanine_phosphoribosyltransferase	denotes	Hprt
T3122	8269-8273	PR_EXT:000010717	denotes	Mtf1
T3123	8339-8344	PR_EXT:000011059	denotes	Ndrg1
T3124	8404-8409	PR_EXT:000014662	denotes	Sepw1
T3125	8469-8477	PR_EXT:000015124	denotes	Slc39a10
T3231	8538-8549	PR_EXT:000025471	denotes	S1 nuclease
T3232	8541-8549	GO_EXT:0004518	denotes	nuclease
T3233	8561-8572	SO_EXT:0000673	denotes	transcripts
T3234	8574-8576	PR_EXT:000025471	denotes	S1
T3235	8587-8589	PR_EXT:000025471	denotes	S1
T3236	8656-8663	GO_PR_EXT:deoxyribonuclease_I	denotes	DNase I
T3237	8679-8682	CHEBI_SO_EXT:RNA	denotes	RNA
T3238	8684-8687	CHEBI_SO_EXT:RNA	denotes	RNA
T3239	8770-8779	CHEBI_EXT:polyatomic_entity_or_group	denotes	Molecular
T3240	8791-8793	PR_EXT:000025471	denotes	S1
T3241	8831-8834	CHEBI:37972	denotes	32P
T3242	8835-8842	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeled
T3243	8843-8859	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotides
T3244	8861-8865	GO_PR_EXT:hypoxanthine_guanine_phosphoribosyltransferase	denotes	Hprt
T3245	8866-8868	PR_EXT:000025471	denotes	S1
T3246	8950-8955	PR_EXT:000014662	denotes	Sepw1
T3247	8956-8958	PR_EXT:000025471	denotes	S1
T3306	9103-9110	CHEBI_PR_EXT:protein	denotes	Protein
T3307	9130-9135	UBERON:0002107	denotes	liver
T3308	9136-9142	UBERON:0000479	denotes	tissue
T3309	9155-9161	UBERON:0000479	denotes	Tissue
T3310	9162-9169	CHEBI_PR_EXT:protein	denotes	Protein
T3311	9181-9188	CHEBI_EXT:33893	denotes	Reagent
T3312	9266-9271	NCBITaxon:10088	denotes	mouse
T3313	9272-9278	UBERON:0000479	denotes	tissue
T3314	9293-9300	CHEBI_EXT:33893	denotes	reagent
T3315	9372-9379	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T3316	9430-9433	CHEBI:37972	denotes	32P
T3317	9438-9445	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeled
T3318	9446-9478	SO_EXT:0000442	denotes	double-stranded oligonucleotides
T3319	9462-9478	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotides
T3320	9498-9503	UBERON:0002107	denotes	liver
T3321	9504-9511	CHEBI_PR_EXT:protein	denotes	protein
T3322	9562-9569	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeled
T3323	9581-9596	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotide
T3324	9614-9621	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T3325	9714-9723	CHEBI_EXT:polyatomic_entity_or_group	denotes	Molecular
T3326	9749-9765	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotides
T3327	9771-9779	GO:0097617	denotes	annealed
T3328	9808-9813	PR_EXT:000005958	denotes	Csrp1
T3329	9893-9898	PR_EXT:000005958	denotes	Csrp1
T3330	9975-9980	PR_EXT:000005958	denotes	Csrp1
T3331	10057-10062	PR_EXT:000005958	denotes	Csrp1
T3332	10139-10143	PR_EXT:P04386	denotes	Gal4
T3333	10224-10229	NCBITaxon:10088	denotes	mouse
T3334	10230-10233	PR_EXT:000010925	denotes	Mt1
T3335	10234-10242	SO_EXT:0000167	denotes	promoter
T3336	10343-10352	_FRAGMENT	denotes	synthetic
T3337	10367-10375	SO:0000351	denotes	sequence
T3338	10357-10366	SO:0000993	denotes	consensus
T3339	10469-10474	PR_EXT:000011059	denotes	Ndrg1
T3340	10547-10552	PR_EXT:000011059	denotes	Ndrg1
T3341	10625-10630	PR_EXT:000011059	denotes	Ndrg1
T3342	10734-10739	PR_EXT:000014662	denotes	Sepw1
T3343	10829-10834	PR_EXT:000014662	denotes	Sepw1
T3344	10913-10921	PR_EXT:000015124	denotes	Slc39a10
T3345	11007-11015	PR_EXT:000015124	denotes	Slc39a10
T3346	11092-11113	PR_EXT:000000133	denotes	Specificity protein 1
T3347	11104-11111	CHEBI_PR_EXT:protein	denotes	protein
T3348	11115-11118	PR_EXT:000000133	denotes	Sp1
T3349	11120-11127	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T3350	11128-11136	SO_EXT:biological_sequence	denotes	sequence
T4194	11198-11202	CL_GO_EXT:cell	denotes	Cell
T4195	11219-11228	UBERON:0000922	denotes	embryonic
T4196	11229-11240	CL:0000057	denotes	fibroblasts
T4197	11275-11279	PR_EXT:000010717	denotes	Mtf1
T4198	11279-11283	SO_EXT:0000346	denotes	loxP
T4199	11284-11289	NCBITaxon:10088	denotes	mouse
T4200	11290-11296	UBERON:0000922	denotes	embryo
T4201	11301-11306	GO:0040007	denotes	grown
T4202	11343-11349	NCBITaxon:27592	denotes	bovine
T4203	11350-11355	UBERON:0001977	denotes	serum
T4204	11372-11382	CHEBI:17334	denotes	penicillin
T4205	11383-11395	CHEBI:17076	denotes	streptomycin
T4206	11417-11428	CHEBI_EXT:L_glutamine	denotes	l-glutamine
T4207	11419-11428	CHEBI_SO_EXT:glutamine	denotes	glutamine
T4208	11461-11474	CL:0000001	denotes	primary cells
T4209	11469-11474	CL_GO_EXT:cell	denotes	cells
T4210	11480-11491	GO:0009294	denotes	transfected
T4211	11509-11519	GO:0010467	denotes	expression
T4212	11520-11527	SO_EXT:0000155	denotes	plasmid
T4213	11528-11534	SO_EXT:sequence_coding_function	denotes	coding
T4214	11539-11554	NCBITaxon:10633	denotes	simian virus 40
T4215	11556-11560	NCBITaxon:10633	denotes	SV40
T4216	11570-11577	CHEBI_EXT:59132	denotes	antigen
T4217	11592-11607	NCBITaxon:10358	denotes	cytomegalovirus
T4218	11609-11612	NCBITaxon:10358	denotes	CMV
T4219	11614-11622	SO_EXT:0000167	denotes	promoter
T4220	11645-11652	CHEBI_EXT:33893	denotes	reagent
T4221	11712-11716	CL_GO_EXT:cell	denotes	Cell
T4222	11757-11762	NCBITaxon:10088	denotes	mouse
T4223	11763-11772	UBERON:0000922	denotes	embryonic
T4224	11763-11772	_FRAGMENT	denotes	embryonic
T4225	11784-11788	CL:0002321	denotes	cell
T4226	11773-11788	CL:0000057	denotes	fibroblast cell
T4227	11784-11788	CL_GO_EXT:cell	denotes	cell
T4228	11833-11837	PR_EXT:000010717	denotes	Mtf1
T4229	11837-11841	SO_EXT:0000346	denotes	loxP
T4230	11842-11850	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T4231	11879-11886	SO_EXT:0001026	denotes	genomic
T4232	11908-11915	CHEBI_EXT:59132	denotes	antigen
T4233	11964-11969	CL_GO_EXT:cell	denotes	cells
T4234	11983-11994	GO:0009294	denotes	transfected
T4235	12002-12019	CHEBI:77635	denotes	calcium phosphate
T4236	12051-12061	GO:0010467	denotes	expression
T4237	12062-12069	SO_EXT:0000155	denotes	plasmid
T4238	12078-12089	GO_EXT:recombinase	denotes	recombinase
T4239	12104-12107	NCBITaxon:10358	denotes	CMV
T4240	12108-12116	SO_EXT:0000167	denotes	promoter
T4241	12134-12144	GO:0010467	denotes	expression
T4242	12145-12152	SO_EXT:0000155	denotes	plasmid
T4243	12161-12169	CHEBI:7507	denotes	neomycin
T4244	12181-12185	SO_EXT:0000704	denotes	gene
T4245	12196-12203	GO:0065007	denotes	control
T4246	12211-12213	GO_PR_EXT:thymidine_kinase	denotes	TK
T4247	12214-12222	SO_EXT:0000167	denotes	promoter
T4248	12231-12242	GO:0009294	denotes	transfected
T4249	12243-12248	CL_GO_EXT:cell	denotes	cells
T4250	12292-12296	CHEBI:42768	denotes	G418
T4251	12320-12326	SO_EXT:sequence_cloned_entity	denotes	clones
T4252	12340-12345	CL_GO_EXT:cell	denotes	cells
T4253	12365-12370	GO:0040007	denotes	grown
T4254	12394-12404	GO:0010467	denotes	expression
T4255	12412-12423	GO_EXT:recombinase	denotes	recombinase
T4256	12428-12436	SO_EXT:sequence_deletion_process	denotes	excision
T4257	12440-12445	SO_EXT:0000147	denotes	exons
T4258	12457-12461	PR_EXT:000010717	denotes	Mtf1
T4259	12479-12481	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T4260	12491-12495	CL_GO_EXT:cell	denotes	cell
T4261	12535-12543	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T4262	12547-12551	PR_EXT:000010717	denotes	Mtf1
T4440	12628-12633	CL_GO_EXT:cell	denotes	cells
T4441	12662-12668	UBERON:0000479	denotes	tissue
T4442	12699-12705	GO_PATO_EXT:biological_adhesion_or_attachedness	denotes	adhere
T4443	12720-12725	CL_GO_EXT:cell	denotes	cells
T4444	12802-12832	CHEBI:28714	denotes	l-buthionine-[S,R]-sulfoximine
T4445	12834-12837	CHEBI:28714	denotes	BSO
T4446	12850-12854	CHEBI_EXT:23888	denotes	drug
T4447	12869-12880	CHEBI:16856	denotes	glutathione
T4448	12869-12890	GO:0006750	denotes	glutathione synthesis
T4449	12904-12909	CL_GO_EXT:cell	denotes	cells
T4450	12944-12949	CHEBI:35456	denotes	CdCl2
T4451	13048-13051	CHEBI:53233	denotes	MTT
T4452	13053-13113	CHEBI:53233	denotes	3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromid
T4453	13121-13125	CL_GO_EXT:cell	denotes	Cell
T4454	13121-13139	GO:0008283	denotes	Cell Proliferation
T4578	13238-13243	UBERON:0002107	denotes	liver
T4579	13253-13257	PR_EXT:000010717	denotes	Mtf1
T4580	13267-13272	NCBITaxon:10088	denotes	mouse
T4581	13297-13310	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T4582	13321-13325	NCBITaxon:10088	denotes	mice
T4583	13347-13355	SO_EXT:sequence_alteration_process	denotes	modified
T4584	13356-13360	PR_EXT:000010717	denotes	Mtf1
T4585	13361-13367	SO_EXT:0001023	denotes	allele
T4586	13368-13372	PR_EXT:000010717	denotes	Mtf1
T4587	13372-13376	SO_EXT:0000346	denotes	loxP
T4588	13383-13388	SO_EXT:0000147	denotes	exons
T4589	13398-13406	SO_EXT:sequence_coding_function	denotes	encoding
T4590	13423-13427	CHEBI_EXT:zinc	denotes	zinc
T4591	13443-13446	CHEBI_SO_EXT:DNA	denotes	DNA
T4592	13447-13454	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T4593	13455-13461	SO_EXT:0000417	denotes	domain
T4594	13467-13474	SO:0000357	denotes	flanked
T4595	13478-13488	SO_EXT:0000346	denotes	loxP sites
T4596	13502-13506	NCBITaxon:10088	denotes	Mice
T4597	13526-13530	PR_EXT:000010717	denotes	Mtf1
T4598	13530-13534	SO_EXT:0000346	denotes	loxP
T4599	13535-13541	SO_EXT:0001023	denotes	allele
T4600	13568-13575	NCBITaxon:33208	denotes	animals
T4601	13587-13598	GO_EXT:recombinase	denotes	recombinase
T4602	13599-13609	SO_EXT:transgenic_entity	denotes	transgenic
T4603	13615-13617	PR_EXT:000010788	denotes	Mx
T4604	13627-13638	GO_EXT:recombinase	denotes	recombinase
T4605	13642-13651	GO:0010467	denotes	expressed
T4606	13675-13682	GO:0065007	denotes	control
T4607	13690-13695	NCBITaxon:10088	denotes	mouse
T4608	13696-13699	PR_EXT:000010788	denotes	Mx1
T4609	13700-13704	SO_EXT:0000704	denotes	gene
T4610	13705-13713	SO_EXT:0000167	denotes	promoter
T4611	13755-13771	PR_EXT:000024938	denotes	interferon alpha
T4612	13755-13765	_FRAGMENT	denotes	interferon
T4613	13775-13779	PR_EXT:000024939	denotes	beta
T4614	13794-13813	CHEBI_SO_EXT:double_stranded_RNA	denotes	double-stranded RNA
T4615	13814-13816	CHEBI:76777	denotes	pI
T4616	13817-13819	CHEBI_EXT:polyC_acid	denotes	pC
T4617	13839-13847	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T4618	13883-13888	UBERON:0002107	denotes	liver
T4619	13913-13920	UBERON:0000479	denotes	tissues
T4620	13942-13948	UBERON:0002106	denotes	spleen
T4621	13958-13963	UBERON:0000955	denotes	brain
T4622	13989-13997	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T4623	14001-14006	SO_EXT:0000147	denotes	exons
T4624	14035-14045	GO_SO_EXT:frameshift_entity_or_process	denotes	frameshift
T4625	14060-14076	GO_SO_EXT:translational_stop_entity_or_process	denotes	translation stop
T4626	14092-14097	PR_EXT:000010717	denotes	MTF-1
T4627	14098-14105	CHEBI_PR_EXT:protein	denotes	protein
T4628	14144-14155	GO_EXT:recombinase	denotes	recombinase
T4629	14157-14161	PR_EXT:000010717	denotes	Mtf1
T4630	14183-14187	NCBITaxon:10088	denotes	mice
T4631	14202-14204	PR_EXT:000010788	denotes	Mx
T4632	14209-14218	SO_EXT:0000902	denotes	transgene
T4633	14220-14224	PR_EXT:000010717	denotes	Mtf1
T4634	14224-14226	PR_EXT:000010788	denotes	Mx
T4635	14251-14261	UBERON:0001179	denotes	peritoneal
T4636	14262-14264	CHEBI:76777	denotes	pI
T4637	14265-14267	CHEBI_EXT:polyC_acid	denotes	pC
T4638	14299-14301	CHEBI:76777	denotes	pI
T4639	14302-14304	CHEBI_EXT:polyC_acid	denotes	pC
T4640	14345-14354	SO_EXT:0000902	denotes	transgene
T4641	14356-14360	PR_EXT:000010717	denotes	Mtf1
T4642	14360-14364	SO_EXT:0000346	denotes	loxP
T4643	14401-14403	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T4644	14460-14463	CHEBI_SO_EXT:RNA	denotes	RNA
T4645	14469-14473	PR_EXT:000010717	denotes	Mtf1
T4646	14473-14475	PR_EXT:000010788	denotes	Mx
T4647	14480-14486	UBERON:0002107	denotes	livers
T4648	14512-14520	SO_EXT:sequence_deletion_process	denotes	excision
T4649	14524-14529	SO_EXT:0000147	denotes	exons
T4650	14541-14545	PR_EXT:000010717	denotes	Mtf1
T4651	14555-14562	NCBITaxon:33208	denotes	animals
T4652	14669-14673	NCBITaxon:10088	denotes	mice
T4653	14728-14732	PR_EXT:000010717	denotes	Mtf1
T4654	14733-14737	CHEBI_SO_EXT:mRNA	denotes	mRNA
T4655	14763-14768	PR_EXT:000010717	denotes	MTF-1
T4656	14769-14776	CHEBI_PR_EXT:protein	denotes	protein
T4657	14811-14816	PR_EXT:000010717	denotes	MTF-1
T4658	14817-14824	CHEBI_PR_EXT:protein	denotes	protein
T4659	14817-14836	GO:0032993	denotes	protein–DNA complex
T4660	14825-14828	CHEBI_SO_EXT:DNA	denotes	DNA
T4661	14857-14862	UBERON:0002107	denotes	liver
T4662	14863-14870	CHEBI_PR_EXT:protein	denotes	protein
T4663	14887-14891	PR_EXT:000010717	denotes	Mtf1
T4664	14891-14895	SO_EXT:0000346	denotes	loxP
T4665	14904-14909	NCBITaxon:10088	denotes	mouse
T4666	14933-14940	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T4667	14941-14948	CHEBI_PR_EXT:protein	denotes	protein
T4668	14970-14974	PR_EXT:000010717	denotes	Mtf1
T4669	14974-14976	PR_EXT:000010788	denotes	Mx
T4670	14995-15003	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T4671	15007-15012	SO_EXT:0000147	denotes	exons
T4672	15024-15028	PR_EXT:000010717	denotes	Mtf1
T4673	15036-15041	UBERON:0002107	denotes	liver
T4674	15045-15049	PR_EXT:000010717	denotes	Mtf1
T4675	15049-15051	PR_EXT:000010788	denotes	Mx
T4676	15056-15060	NCBITaxon:10088	denotes	mice
T4677	15098-15103	UBERON:0002107	denotes	liver
T4678	15122-15126	NCBITaxon:10088	denotes	mice
T5216	15189-15194	PR_EXT:000010717	denotes	MTF-1
T5217	15202-15206	SO_EXT:0000704	denotes	gene
T5218	15240-15245	PR_EXT:000010717	denotes	MTF-1
T5219	15253-15258	SO_EXT:0000704	denotes	genes
T5220	15276-15281	UBERON:0002107	denotes	liver
T5221	15282-15292	SO_EXT:0000673	denotes	transcript
T5222	15305-15309	NCBITaxon:10088	denotes	mice
T5223	15338-15342	PR_EXT:000010717	denotes	Mtf1
T5224	15343-15347	SO_EXT:0000704	denotes	gene
T5225	15389-15396	CHEBI_EXT:cadmium	denotes	cadmium
T5226	15408-15416	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T5227	15467-15478	SO_EXT:0000673	denotes	transcripts
T5228	15559-15579	SO_EXT:double_stranded_complementary_DNA	denotes	double-stranded cDNA
T5229	15584-15605	SO_EXT:0000412	denotes	restriction fragments
T5230	15722-15725	PR_EXT:000010925	denotes	Mt1
T5231	15730-15733	PR_EXT:000010704	denotes	Mt2
T5232	15766-15777	SO_EXT:0000673	denotes	transcripts
T5233	15817-15824	CHEBI_EXT:cadmium	denotes	cadmium
T5234	15833-15839	UBERON:0002107	denotes	livers
T5235	15867-15872	PR_EXT:000010717	denotes	MTF-1
T5236	15873-15877	SO_EXT:0000704	denotes	gene
T5237	15936-15941	PR_EXT:000010717	denotes	MTF-1
T5238	15961-15966	CHEBI_EXT:metal	denotes	metal
T5239	15975-15985	GO:0010467	denotes	expression
T5240	16005-16010	SO_EXT:0000704	denotes	genes
T5241	16038-16042	SO_EXT:0000704	denotes	gene
T5242	16038-16053	GO:0010467	denotes	gene expression
T5243	16065-16071	UBERON:0002107	denotes	livers
T5244	16095-16099	NCBITaxon:10088	denotes	mice
T5245	16137-16142	NCBITaxon:10088	denotes	Mouse
T5246	16143-16149	SO_EXT:0001026	denotes	Genome
T5247	16195-16200	CHEBI_SO_EXT:molecular_probe	denotes	probe
T5248	16215-16221	UBERON:0002107	denotes	livers
T5249	16240-16244	PR_EXT:000010717	denotes	Mtf1
T5250	16244-16246	PR_EXT:000010788	denotes	Mx
T5251	16255-16259	PR_EXT:000010717	denotes	Mtf1
T5252	16259-16263	SO_EXT:0000346	denotes	loxP
T5253	16264-16268	NCBITaxon:10088	denotes	mice
T5254	16299-16327	GO:0010629	denotes	downregulation of expression
T5255	16344-16348	PR_EXT:000010717	denotes	Mtf1
T5256	16348-16350	PR_EXT:000010788	denotes	Mx
T5257	16355-16361	UBERON:0002107	denotes	livers
T5258	16390-16395	CHEBI_SO_EXT:molecular_probe	denotes	probe
T5259	16435-16440	SO_EXT:0000704	denotes	genes
T5260	16470-16475	SO_EXT:0000704	denotes	genes
T5261	16505-16514	SO:0000993	denotes	consensus
T5262	16515-16523	SO_EXT:biological_sequence	denotes	sequence
T5263	16557-16559	SO_EXT:0000028	denotes	bp
T5264	16560-16568	SO_EXT:sequence_upstreamness	denotes	upstream
T5265	16576-16595	GO_SO_EXT:transcriptional_start_entity_or_process	denotes	transcription start
T5266	16604-16609	CHEBI_SO_EXT:molecular_probe	denotes	probe
T5267	16659-16664	SO_EXT:0000704	denotes	genes
T5268	16695-16707	GO_EXT:positive_regulation	denotes	upregulation
T5269	16724-16728	PR_EXT:000010717	denotes	Mtf1
T5270	16728-16730	PR_EXT:000010788	denotes	Mx
T5271	16735-16741	UBERON:0002107	denotes	livers
T5272	16771-16776	SO_EXT:0000704	denotes	genes
T5273	16794-16803	SO:0000993	denotes	consensus
T5274	16804-16813	SO_EXT:biological_sequence	denotes	sequences
T5275	16821-16829	SO_EXT:sequence_upstreamness	denotes	upstream
T5276	16855-16861	UBERON:0002107	denotes	livers
T5277	16865-16872	CHEBI_EXT:cadmium	denotes	cadmium
T5278	16881-16885	PR_EXT:000010717	denotes	Mtf1
T5279	16885-16887	PR_EXT:000010788	denotes	Mx
T5280	16896-16900	PR_EXT:000010717	denotes	Mtf1
T5281	16900-16904	SO_EXT:0000346	denotes	loxP
T5282	16905-16909	NCBITaxon:10088	denotes	mice
T5283	16948-16962	GO_EXT:negative_regulation	denotes	downregulation
T5284	16966-16970	PR_EXT:000010717	denotes	Mtf1
T5285	16970-16972	PR_EXT:000010788	denotes	Mx
T5286	16977-16983	UBERON:0002107	denotes	livers
T5287	16991-16996	CHEBI_SO_EXT:molecular_probe	denotes	probe
T5288	17046-17051	SO_EXT:0000704	denotes	genes
T5289	17095-17104	SO:0000993	denotes	consensus
T5290	17105-17114	SO_EXT:biological_sequence	denotes	sequences
T5291	17124-17132	SO_EXT:sequence_upstreamness	denotes	upstream
T5292	17147-17152	CHEBI_SO_EXT:molecular_probe	denotes	probe
T5293	17201-17206	SO_EXT:0000704	denotes	genes
T5294	17237-17249	GO_EXT:positive_regulation	denotes	upregulation
T5295	17302-17308	SO_EXT:sequence_or_structure_motif	denotes	motifs
T5296	17339-17344	SO_EXT:0000704	denotes	genes
T5297	17346-17350	SO_EXT:0000345	denotes	ESTs
T5298	17361-17365	SO_EXT:cDNA	denotes	cDNA
T5299	17366-17375	SO_EXT:biological_sequence	denotes	sequences
T5300	17413-17417	PR_EXT:000010717	denotes	Mtf1
T5301	17417-17419	PR_EXT:000010788	denotes	Mx
T5302	17428-17432	PR_EXT:000010717	denotes	Mtf1
T5303	17432-17436	SO_EXT:0000346	denotes	loxP
T5304	17437-17443	UBERON:0002107	denotes	livers
T5305	17465-17474	GO:0010467	denotes	expressed
T5306	17500-17514	GO_EXT:negative_regulation	denotes	Downregulation
T5307	17518-17521	PR_EXT:000010925	denotes	Mt1
T5308	17526-17529	PR_EXT:000010704	denotes	Mt2
T5309	17546-17550	PR_EXT:000010717	denotes	Mtf1
T5310	17550-17552	PR_EXT:000010788	denotes	Mx
T5311	17557-17563	UBERON:0002107	denotes	livers
T5312	17626-17640	GO_EXT:negative_regulation	denotes	downregulation
T5313	17644-17647	PR_EXT:000010925	denotes	Mt1
T5314	17664-17671	NCBITaxon:33208	denotes	animals
T5315	17713-17718	PR_EXT:000010717	denotes	MTF-1
T5316	17726-17731	SO_EXT:0000704	denotes	genes
T5317	17762-17765	PR_EXT:000010925	denotes	Mt1
T5318	17767-17770	PR_EXT:000010704	denotes	Mt2
T5319	17775-17779	PR_EXT:000015073	denotes	Znt1
T5320	17781-17786	PR_EXT:000010717	denotes	MTF-1
T5321	17798-17813	GO_EXT:transcription	denotes	transcriptional
T5322	17851-17860	SO_EXT:biological_sequence	denotes	sequences
T5323	17885-17904	GO_SO_EXT:transcriptional_start_entity_or_process	denotes	transcription start
T5324	17947-17952	PR_EXT:000010717	denotes	MTF-1
T5325	17953-17960	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T5326	17953-17966	SO_EXT:0000409	denotes	binding sites
T5327	17995-18027	SO_EXT:0000442	denotes	double-stranded oligonucleotides
T5328	18011-18027	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotides
T5329	18040-18049	SO_EXT:biological_sequence	denotes	sequences
T5330	18065-18072	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T5331	18073-18078	SO_EXT:sequence_or_structure_motif	denotes	motif
T5332	18083-18088	PR_EXT:000010717	denotes	MTF-1
T5333	18138-18146	SO_EXT:biological_sequence	denotes	sequence
T5334	18191-18196	PR_EXT:000010717	denotes	MTF-1
T5335	18204-18208	SO_EXT:0000704	denotes	gene
T5336	18241-18245	SO_EXT:0000704	denotes	gene
T6354	18287-18297	GO:0010467	denotes	expression
T6355	18301-18306	PR_EXT:000014662	denotes	Sepw1
T6356	18318-18323	PR_EXT:000010717	denotes	MTF-1
T6357	18324-18329	PR_EXT:000014662	denotes	Sepw1
T6358	18383-18396	GO_EXT:negative_regulation	denotes	downregulated
T6359	18400-18406	UBERON:0002107	denotes	livers
T6360	18412-18419	CHEBI_EXT:cadmium	denotes	cadmium
T6361	18438-18442	PR_EXT:000010717	denotes	Mtf1
T6362	18442-18444	PR_EXT:000010788	denotes	Mx
T6363	18449-18453	NCBITaxon:10088	denotes	mice
T6364	18474-18479	PR_EXT:000014662	denotes	SEPW1
T6365	18485-18499	CHEBI_SO_EXT:selenocysteine	denotes	selenocysteine
T6366	18511-18518	CHEBI_PR_EXT:protein	denotes	protein
T6367	18524-18529	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T6368	18530-18541	CHEBI:16856	denotes	glutathione
T6369	18575-18586	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T6370	18579-18586	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T6371	18601-18606	PR_EXT:000014662	denotes	Sepw1
T6372	18607-18617	GO:0010467	denotes	expression
T6373	18621-18627	UBERON:0002107	denotes	livers
T6374	18631-18633	CHEBI:76777	denotes	pI
T6375	18634-18636	CHEBI_EXT:polyC_acid	denotes	pC
T6376	18655-18662	CHEBI_EXT:cadmium	denotes	cadmium
T6377	18671-18675	PR_EXT:000010717	denotes	Mtf1
T6378	18675-18677	PR_EXT:000010788	denotes	Mx
T6379	18686-18690	PR_EXT:000010717	denotes	Mtf1
T6380	18690-18694	SO_EXT:0000346	denotes	loxP
T6381	18695-18699	NCBITaxon:10088	denotes	mice
T6382	18741-18743	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T6383	18753-18755	PR_EXT:000025471	denotes	S1
T6384	18837-18849	GO_EXT:positive_regulation	denotes	upregulation
T6385	18853-18858	PR_EXT:000014662	denotes	Sepw1
T6386	18859-18872	GO_EXT:transcription	denotes	transcription
T6387	18889-18895	UBERON:0002107	denotes	livers
T6388	18901-18905	PR_EXT:000010717	denotes	Mtf1
T6389	18905-18909	SO_EXT:0000346	denotes	loxP
T6390	18910-18914	NCBITaxon:10088	denotes	mice
T6391	18920-18927	CHEBI_EXT:cadmium	denotes	cadmium
T6392	18970-18976	UBERON:0002107	denotes	livers
T6393	18992-18999	CHEBI_EXT:cadmium	denotes	cadmium
T6394	19008-19012	PR_EXT:000010717	denotes	Mtf1
T6395	19012-19014	PR_EXT:000010788	denotes	Mx
T6396	19019-19023	NCBITaxon:10088	denotes	mice
T6397	19041-19046	PR_EXT:000010717	denotes	MTF-1
T6398	19074-19084	GO:0010467	denotes	expression
T6399	19088-19093	PR_EXT:000014662	denotes	Sepw1
T6400	19110-19119	SO:0000993	denotes	consensus
T6401	19120-19129	SO_EXT:biological_sequence	denotes	sequences
T6402	19155-19163	SO_EXT:sequence_upstreamness	denotes	upstream
T6403	19171-19176	NCBITaxon:10088	denotes	mouse
T6404	19177-19182	PR_EXT:000014662	denotes	Sepw1
T6405	19183-19202	GO_SO_EXT:transcriptional_start_entity_or_process	denotes	transcription start
T6406	19294-19313	GO_SO_EXT:transcriptional_start_entity_or_process	denotes	transcription start
T6407	19325-19327	SO_EXT:0000028	denotes	bp
T6408	19363-19371	SO_EXT:sequence_upstreamness	denotes	upstream
T6409	19384-19386	SO_EXT:0000028	denotes	bp
T6410	19398-19405	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T6411	19409-19414	PR_EXT:000010717	denotes	MTF-1
T6412	19418-19423	PR_EXT:000014662	denotes	Sepw1
T6413	19442-19457	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotide
T6414	19484-19489	UBERON:0002107	denotes	liver
T6415	19490-19497	CHEBI_PR_EXT:protein	denotes	protein
T6416	19514-19518	PR_EXT:000010717	denotes	Mtf1
T6417	19518-19522	SO_EXT:0000346	denotes	loxP
T6418	19531-19536	NCBITaxon:10088	denotes	mouse
T6419	19567-19574	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T6420	19616-19618	CHEBI:76777	denotes	pI
T6421	19619-19621	CHEBI_EXT:polyC_acid	denotes	pC
T6422	19630-19634	PR_EXT:000010717	denotes	Mtf1
T6423	19634-19636	PR_EXT:000010788	denotes	Mx
T6424	19641-19646	NCBITaxon:10088	denotes	mouse
T6425	19718-19723	PR_EXT:000010717	denotes	MTF-1
T6516	19726-19733	CHEBI_EXT:cadmium	denotes	Cadmium
T6517	19734-19742	GO_EXT:reaction_or_response	denotes	response
T6518	19746-19751	PR_EXT:000011059	denotes	Ndrg1
T6519	19763-19768	PR_EXT:000010717	denotes	MTF-1
T6520	19769-19774	PR_EXT:000011059	denotes	Ndrg1
T6521	19793-19806	GO_EXT:negative_regulation	denotes	downregulated
T6522	19825-19830	UBERON:0002107	denotes	liver
T6523	19831-19842	SO_EXT:0000673	denotes	transcripts
T6524	19848-19855	CHEBI_EXT:cadmium	denotes	cadmium
T6525	19864-19868	PR_EXT:000010717	denotes	Mtf1
T6526	19868-19870	PR_EXT:000010788	denotes	Mx
T6527	19875-19879	NCBITaxon:10088	denotes	mice
T6528	19910-19914	PR_EXT:000010717	denotes	Mtf1
T6529	19914-19918	SO_EXT:0000346	denotes	loxP
T6530	19927-19931	NCBITaxon:10088	denotes	mice
T6531	19946-19951	PR_EXT:000011059	denotes	Ndrg1
T6532	19985-19993	GO_EXT:reaction_or_response	denotes	response
T6533	20039-20045	CHEBI_EXT:nickel	denotes	nickel
T6534	20046-20055	CHEBI:36357	denotes	compounds
T6535	20066-20076	GO:0010467	denotes	expression
T6536	20080-20086	NCBITaxon:9989	denotes	rodent
T6537	20087-20092	PR_EXT:000011059	denotes	Ndrg1
T6538	20104-20109	NCBITaxon:9606	denotes	human
T6539	20110-20118	SO_EXT:0000855	denotes	ortholog
T6540	20132-20137	PR_EXT:000011059	denotes	Ndrg1
T6541	20194-20196	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T6542	20219-20223	PR_EXT:000010717	denotes	Mtf1
T6543	20223-20227	SO_EXT:0000346	denotes	loxP
T6544	20236-20242	UBERON:0002107	denotes	livers
T6545	20264-20269	PR_EXT:000011059	denotes	Ndrg1
T6546	20270-20280	GO:0010467	denotes	expression
T6547	20300-20307	CHEBI_EXT:cadmium	denotes	cadmium
T6548	20321-20327	UBERON:0002107	denotes	livers
T6549	20333-20337	PR_EXT:000010717	denotes	Mtf1
T6550	20337-20339	PR_EXT:000010788	denotes	Mx
T6551	20344-20348	NCBITaxon:10088	denotes	mice
T6552	20355-20362	CHEBI_EXT:cadmium	denotes	cadmium
T6553	20363-20371	GO_EXT:reaction_or_response	denotes	response
T6554	20404-20414	GO:0010467	denotes	expression
T6555	20460-20467	CHEBI_EXT:cadmium	denotes	cadmium
T6556	20476-20486	GO:0010467	denotes	expression
T6557	20490-20495	PR_EXT:000011059	denotes	Ndrg1
T6558	20507-20512	PR_EXT:000010717	denotes	MTF-1
T6559	20528-20537	SO:0000993	denotes	consensus
T6560	20538-20547	SO_EXT:biological_sequence	denotes	sequences
T6561	20560-20568	SO_EXT:sequence_upstreamness	denotes	upstream
T6562	20576-20581	NCBITaxon:10088	denotes	mouse
T6563	20582-20587	PR_EXT:000011059	denotes	Ndrg1
T6564	20588-20607	GO_SO_EXT:transcriptional_start_entity_or_process	denotes	transcription start
T6565	20676-20678	SO_EXT:0000028	denotes	bp
T6566	20714-20722	SO_EXT:sequence_upstreamness	denotes	upstream
T6567	20735-20737	SO_EXT:0000028	denotes	bp
T6568	20775-20780	PR_EXT:000010717	denotes	MTF-1
T6569	20838-20847	SO_EXT:biological_sequence	denotes	sequences
T6570	20870-20886	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotides
T6571	20930-20945	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotide
T6572	20960-20969	SO_EXT:biological_sequence	denotes	sequences
T6573	21010-21017	GO:0032991	denotes	complex
T6574	21051-21056	PR_EXT:000010717	denotes	MTF-1
T6575	21057-21066	GO:0032991	denotes	complexes
T6576	21110-21126	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotides
T6577	21132-21137	UBERON:0002107	denotes	liver
T6578	21138-21145	CHEBI_PR_EXT:protein	denotes	protein
T6579	21162-21166	PR_EXT:000010717	denotes	Mtf1
T6580	21166-21170	SO_EXT:0000346	denotes	loxP
T6581	21171-21176	NCBITaxon:10088	denotes	mouse
T6582	21222-21229	CHEBI_PR_EXT:protein	denotes	protein
T6583	21245-21250	NCBITaxon:10088	denotes	mouse
T6584	21259-21264	PR_EXT:000010717	denotes	MTF-1
T6585	21266-21270	PR_EXT:000010717	denotes	Mtf1
T6586	21270-21272	PR_EXT:000010788	denotes	Mx
T7188	21280-21287	CHEBI_EXT:cadmium	denotes	Cadmium
T7189	21288-21296	GO_EXT:reaction_or_response	denotes	response
T7190	21300-21305	PR_EXT:000005958	denotes	Csrp1
T7191	21317-21322	PR_EXT:000010717	denotes	MTF-1
T7192	21323-21328	PR_EXT:000005958	denotes	Csrp1
T7193	21382-21395	GO_EXT:negative_regulation	denotes	downregulated
T7194	21399-21406	CHEBI_EXT:cadmium	denotes	cadmium
T7195	21415-21419	PR_EXT:000010717	denotes	Mtf1
T7196	21419-21421	PR_EXT:000010788	denotes	Mx
T7197	21426-21430	NCBITaxon:10088	denotes	mice
T7198	21443-21447	PR_EXT:000010717	denotes	Mtf1
T7199	21447-21451	SO_EXT:0000346	denotes	loxP
T7200	21452-21456	NCBITaxon:10088	denotes	mice
T7201	21471-21476	PR_EXT:000005958	denotes	CSRP1
T7202	21496-21518	SO_EXT:biological_conservation_process_or_quality	denotes	evolutionary conserved
T7203	21533-21541	CHEBI_PR_EXT:protein	denotes	proteins
T7204	21571-21581	GO_EXT:muscle_structure_or_tissue_development	denotes	myogenesis
T7205	21586-21598	GO:0005856	denotes	cytoskeletal
T7206	21636-21638	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T7207	21691-21696	PR_EXT:000005958	denotes	Csrp1
T7208	21697-21707	GO:0010467	denotes	expression
T7209	21723-21727	PR_EXT:000010717	denotes	Mtf1
T7210	21727-21731	SO_EXT:0000346	denotes	loxP
T7211	21732-21738	UBERON:0002107	denotes	livers
T7212	21744-21751	CHEBI_EXT:cadmium	denotes	cadmium
T7213	21790-21797	CHEBI_EXT:cadmium	denotes	cadmium
T7214	21798-21806	GO_EXT:reaction_or_response	denotes	response
T7215	21825-21831	UBERON:0002107	denotes	livers
T7216	21837-21841	PR_EXT:000010717	denotes	Mtf1
T7217	21841-21843	PR_EXT:000010788	denotes	Mx
T7218	21848-21852	NCBITaxon:10088	denotes	mice
T7219	21870-21875	PR_EXT:000010717	denotes	MTF-1
T7220	21892-21899	CHEBI_EXT:cadmium	denotes	cadmium
T7221	21913-21918	PR_EXT:000005958	denotes	Csrp1
T7222	21935-21944	SO:0000993	denotes	consensus
T7223	21945-21954	SO_EXT:biological_sequence	denotes	sequences
T7224	21966-21974	SO_EXT:sequence_upstreamness	denotes	upstream
T7225	21982-21987	PR_EXT:000005958	denotes	Csrp1
T7226	21988-22007	GO_SO_EXT:transcriptional_start_entity_or_process	denotes	transcription start
T7227	22035-22037	SO_EXT:0000028	denotes	bp
T7228	22066-22076	SO_EXT:sequence_downstreamness	denotes	downstream
T7229	22087-22089	SO_EXT:0000028	denotes	bp
T7230	22112-22119	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T7231	22123-22128	PR_EXT:000010717	denotes	MTF-1
T7232	22161-22176	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotide
T7233	22181-22188	CHEBI_PR_EXT:protein	denotes	protein
T7234	22205-22209	PR_EXT:000010717	denotes	Mtf1
T7235	22209-22213	SO_EXT:0000346	denotes	loxP
T7236	22214-22219	UBERON:0002107	denotes	liver
T7237	22232-22236	PR_EXT:000010717	denotes	Mtf1
T7238	22236-22238	PR_EXT:000010788	denotes	Mx
T7239	22243-22248	UBERON:0002107	denotes	liver
T7240	22265-22270	PR_EXT:000010717	denotes	MTF-1
T7241	22304-22309	PR_EXT:000010717	denotes	MTF-1
T7242	22317-22324	GO:0032991	denotes	complex
T7345	22339-22344	PR_EXT:000010717	denotes	MTF-1
T7346	22354-22364	GO:0010467	denotes	expression
T7347	22368-22376	PR_EXT:000015124	denotes	Slc39a10
T7348	22377-22385	PR_EXT:000015124	denotes	Slc39a10
T7349	22442-22453	GO_EXT:positive_regulation	denotes	upregulated
T7350	22457-22463	UBERON:0002107	denotes	livers
T7351	22484-22491	CHEBI_EXT:cadmium	denotes	cadmium
T7352	22500-22504	PR_EXT:000010717	denotes	Mtf1
T7353	22504-22506	PR_EXT:000010788	denotes	Mx
T7354	22511-22515	NCBITaxon:10088	denotes	mice
T7355	22536-22543	NCBITaxon:33208	denotes	animals
T7356	22570-22578	CHEBI_PR_EXT:protein	denotes	proteins
T7357	22616-22623	CHEBI_PR_EXT:protein	denotes	protein
T7358	22640-22645	CHEBI_EXT:metal	denotes	metal
T7359	22640-22662	GO_EXT:0046873	denotes	metal ion transporters
T7360	22646-22649	CHEBI:24870	denotes	ion
T7361	22650-22662	GO_EXT:biological_mover_or_transporter	denotes	transporters
T7362	22668-22677	GO_EXT:biological_routing_or_transport	denotes	transport
T7363	22704-22709	CHEBI_EXT:metal	denotes	metal
T7364	22710-22713	CHEBI:24870	denotes	ion
T7365	22732-22740	CL_GO_EXT:cell	denotes	cellular
T7366	22732-22750	GO:0005886	denotes	cellular membranes
T7367	22760-22769	GO:0005737	denotes	cytoplasm
T7368	22832-22834	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T7369	22849-22866	_FRAGMENT	denotes	downregulation of
T7370	22876-22886	GO:0010629	denotes	expression
T7371	22867-22875	PR_EXT:000015124	denotes	Slc39a10
T7372	22890-22896	UBERON:0002107	denotes	livers
T7373	22900-22904	PR_EXT:000010717	denotes	Mtf1
T7374	22904-22908	SO_EXT:0000346	denotes	loxP
T7375	22909-22913	NCBITaxon:10088	denotes	mice
T7376	22919-22926	CHEBI_EXT:cadmium	denotes	cadmium
T7377	22953-22957	PR_EXT:000010717	denotes	Mtf1
T7378	22957-22959	PR_EXT:000010788	denotes	Mx
T7379	22964-22968	NCBITaxon:10088	denotes	mice
T7380	22980-22990	GO:0010467	denotes	expression
T7381	23020-23027	CHEBI_EXT:cadmium	denotes	cadmium
T7382	23070-23078	PR_EXT:000015124	denotes	Slc39a10
T7383	23079-23089	GO:0010467	denotes	expression
T7384	23164-23171	CHEBI_EXT:cadmium	denotes	cadmium
T7385	23193-23201	PR_EXT:000015124	denotes	Slc39a10
T7386	23202-23215	GO_EXT:transcription	denotes	transcription
T7387	23234-23238	PR_EXT:000010717	denotes	Mtf1
T7388	23238-23240	PR_EXT:000010788	denotes	Mx
T7389	23249-23253	PR_EXT:000010717	denotes	Mtf1
T7390	23253-23257	SO_EXT:0000346	denotes	loxP
T7391	23258-23262	NCBITaxon:10088	denotes	mice
T7392	23290-23295	PR_EXT:000010717	denotes	MTF-1
T7393	23339-23353	GO_EXT:negative_regulation	denotes	downregulation
T7394	23398-23404	UBERON:0002107	denotes	livers
T7395	23464-23469	CHEBI_SO_EXT:molecular_probe	denotes	probe
T7396	23518-23523	PR_EXT:000010717	denotes	MTF-1
T7397	23563-23573	GO:0010467	denotes	expression
T7398	23577-23585	PR_EXT:000015124	denotes	Slc39a10
T7399	23620-23627	CHEBI_EXT:cadmium	denotes	cadmium
T7400	23628-23636	GO_EXT:reaction_or_response	denotes	response
T7401	23645-23649	SO_EXT:0000704	denotes	gene
T7402	23714-23723	SO:0000993	denotes	consensus
T7403	23724-23732	SO_EXT:biological_sequence	denotes	sequence
T7404	23748-23756	SO_EXT:sequence_upstreamness	denotes	upstream
T7405	23764-23769	NCBITaxon:10088	denotes	mouse
T7406	23770-23778	PR_EXT:000015124	denotes	Slc39a10
T7407	23779-23798	GO_SO_EXT:transcriptional_start_entity_or_process	denotes	transcription start
T7408	23810-23812	SO_EXT:0000028	denotes	bp
T7409	23836-23846	SO_EXT:sequence_downstreamness	denotes	downstream
T7410	23858-23860	SO_EXT:0000028	denotes	bp
T7411	23883-23890	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T7412	23894-23899	PR_EXT:000010717	denotes	MTF-1
T7413	23944-23949	UBERON:0002107	denotes	liver
T7414	23950-23957	CHEBI_PR_EXT:protein	denotes	protein
T7415	23974-23978	PR_EXT:000010717	denotes	Mtf1
T7416	23978-23982	SO_EXT:0000346	denotes	loxP
T7417	23999-24003	PR_EXT:000010717	denotes	Mtf1
T7418	24003-24005	PR_EXT:000010788	denotes	Mx
T7419	24010-24015	NCBITaxon:10088	denotes	mouse
T7420	24026-24033	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T7972	24071-24078	CHEBI_EXT:cadmium	denotes	Cadmium
T7973	24091-24096	PR_EXT:000010717	denotes	MTF-1
T7974	24109-24114	SO_EXT:0000704	denotes	genes
T7975	24155-24162	CHEBI_EXT:cadmium	denotes	cadmium
T7976	24174-24179	SO_EXT:0000704	denotes	genes
T7977	24205-24210	PR_EXT:000010717	denotes	MTF-1
T7978	24238-24243	CHEBI_SO_EXT:molecular_probe	denotes	probe
T7979	24262-24269	CHEBI_EXT:cadmium	denotes	cadmium
T7980	24278-24282	NCBITaxon:10088	denotes	mice
T7981	24317-24321	NCBITaxon:10088	denotes	mice
T7982	24343-24351	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T7983	24392-24404	GO_EXT:positive_regulation	denotes	upregulation
T7984	24424-24431	CHEBI_EXT:cadmium	denotes	cadmium
T7985	24448-24453	CHEBI_SO_EXT:molecular_probe	denotes	probe
T7986	24503-24508	SO_EXT:0000704	denotes	genes
T7987	24529-24534	CHEBI_SO_EXT:molecular_probe	denotes	probe
T7988	24573-24578	SO_EXT:0000704	denotes	genes
T7989	24599-24613	GO_EXT:negative_regulation	denotes	downregulation
T7990	24649-24654	SO_EXT:0000704	denotes	genes
T7991	24671-24684	_FRAGMENT	denotes	metabolism of
T7992	24701-24712	GO:0006749	denotes	glutathione
T7993	24689-24700	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T7994	24693-24700	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T7995	24701-24712	CHEBI:16856	denotes	glutathione
T7996	24730-24741	GO_EXT:positive_regulation	denotes	upregulated
T7997	24745-24752	CHEBI_EXT:cadmium	denotes	cadmium
T7998	24774-24779	SO_EXT:0000704	denotes	genes
T7999	24780-24788	SO_EXT:sequence_coding_function	denotes	encoding
T8000	24793-24802	GO_MOP_EXT:catalysis	denotes	catalytic
T8001	24793-24839	PR_EXT:000007897	denotes	catalytic subunit of glutamate-cysteine ligase
T8002	24814-24823	CHEBI_EXT:glutamate	denotes	glutamate
T8003	24814-24839	GO_EXT:0004357	denotes	glutamate-cysteine ligase
T8004	24824-24832	CHEBI_SO_EXT:cysteine	denotes	cysteine
T8005	24841-24845	PR_EXT:000007897	denotes	Gclc
T8006	24841-24845	GO_EXT:0004357	denotes	Gclc
T8007	24873-24879	CHEBI_GO_SO_EXT:enzyme	denotes	enzyme
T8008	24891-24915	GO:0006750	denotes	synthesis of glutathione
T8009	24904-24915	CHEBI:16856	denotes	glutathione
T8010	24922-24933	CHEBI:16856	denotes	glutathione
T8011	24922-24943	GO_PR_EXT:glutathione_disulfide_reductase	denotes	glutathione reductase
T8012	24922-24945	PR_EXT:000008292	denotes	glutathione reductase 1
T8013	24947-24950	GO_PR_EXT:glutathione_disulfide_reductase	denotes	Gsr
T8014	24957-24965	MOP:0000569	denotes	reducing
T8015	24966-24972	CHEBI_GO_SO_EXT:enzyme	denotes	enzyme
T8016	24977-24985	MOP:0000568	denotes	oxidized
T8017	24977-24997	CHEBI:17858	denotes	oxidized glutathione
T8018	25008-25019	CHEBI:16856	denotes	glutathione
T8019	25008-25033	GO_PR_EXT:glutathione_S_transferase	denotes	glutathione-S-transferase
T8020	25008-25039	PR_EXT:000030257	denotes	glutathione-S-transferase, mu 4
T8021	25020-25021	CHEBI_EXT:sulfur	denotes	S
T8022	25041-25046	PR_EXT:000030257	denotes	Gstm4
T8023	25074-25085	CHEBI:16856	denotes	glutathione
T8024	25074-25099	GO_PR_EXT:glutathione_S_transferase	denotes	glutathione-S-transferase
T8025	25086-25087	CHEBI_EXT:sulfur	denotes	S
T8026	25120-25134	GO:0098754	denotes	detoxification
T8027	25135-25142	CHEBI_GO_SO_EXT:enzyme	denotes	enzymes
T8028	25216-25218	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T8029	25242-25246	PR_EXT:000007897	denotes	Gclc
T8030	25242-25246	GO_EXT:0004357	denotes	Gclc
T8031	25268-25324	PR_EXT:000007897	denotes	heavy chain subunit of gamma-glutamylcysteine synthetase
T8032	25291-25313	CHEBI:24195	denotes	gamma-glutamylcysteine
T8033	25291-25324	GO_EXT:0004357	denotes	gamma-glutamylcysteine synthetase
T8034	25326-25330	GO_EXT:0004357	denotes	Ggcs
T8035	25326-25333	PR_EXT:000007897	denotes	Ggcs-hc
T8036	25378-25382	SO_EXT:0000704	denotes	gene
T8037	25386-25391	PR_EXT:000010717	denotes	MTF-1
T8038	25401-25411	GO:0010467	denotes	expression
T8039	25431-25435	PR_EXT:000007897	denotes	Gclc
T8040	25431-25435	GO_EXT:0004357	denotes	Gclc
T8041	25450-25457	CHEBI_EXT:cadmium	denotes	cadmium
T8042	25479-25484	UBERON:0007023	denotes	adult
T8043	25485-25490	NCBITaxon:10088	denotes	mouse
T8044	25491-25496	UBERON:0002107	denotes	liver
T8045	25515-25520	PR_EXT:000010717	denotes	MTF-1
T8046	25549-25560	CHEBI:16856	denotes	glutathione
T8047	25575-25583	CL_GO_EXT:cell	denotes	cellular
T8048	25575-25583	_FRAGMENT	denotes	cellular
T8049	25592-25600	GO:0051716	denotes	response
T8050	25584-25591	CHEBI_EXT:cadmium	denotes	cadmium
T8051	25602-25607	NCBITaxon:10088	denotes	mouse
T8052	25608-25617	UBERON:0000922	denotes	embryonic
T8053	25618-25629	CL:0000057	denotes	fibroblasts
T8054	25658-25662	PR_EXT:000010717	denotes	Mtf1
T8055	25681-25688	CHEBI_EXT:cadmium	denotes	cadmium
T8056	25709-25712	CHEBI:28714	denotes	BSO
T8057	25725-25737	_FRAGMENT	denotes	inhibitor of
T8058	25757-25763	CHEBI_GO_EXT:ligase_inhibitor	denotes	ligase
T8059	25725-25763	CHEBI_EXT:75599	denotes	inhibitor of glutamate-cysteine ligase
T8060	25738-25763	GO_EXT:0004357	denotes	glutamate-cysteine ligase
T8061	25748-25756	CHEBI_SO_EXT:cysteine	denotes	cysteine
T8062	25774-25778	CL_GO_EXT:cell	denotes	cell
T8063	25839-25850	CHEBI:78021	denotes	tetrazolium
T8064	25851-25855	CHEBI:24866	denotes	salt
T8065	25856-25859	CHEBI:53233	denotes	MTT
T8066	25901-25904	CHEBI:28714	denotes	BSO
T8067	25908-25915	CHEBI_EXT:cadmium	denotes	cadmium
T8068	25969-25973	CL_GO_EXT:cell	denotes	cell
T8069	26001-26004	CHEBI:28714	denotes	BSO
T8070	26009-26016	CHEBI_EXT:cadmium	denotes	cadmium
T8071	26041-26050	GO_EXT:fatality_or_lethality	denotes	lethality
T8072	26072-26077	CL_GO_EXT:cell	denotes	cells
T8073	26097-26101	PR_EXT:000010717	denotes	Mtf1
T8074	26134-26145	CHEBI:16856	denotes	glutathione
T8075	26170-26174	PR_EXT:000010717	denotes	Mtf1
T8076	26200-26207	CHEBI_EXT:cadmium	denotes	cadmium
T8077	26208-26215	GO:0006952	denotes	defense
T8078	26232-26243	CHEBI:16856	denotes	glutathione
T8079	26262-26267	PR_EXT:000010717	denotes	MTF-1
T8080	26283-26288	SO_EXT:0000704	denotes	genes
T8081	26327-26331	CL_GO_EXT:cell	denotes	cell
T8082	26338-26345	CHEBI_EXT:cadmium	denotes	cadmium
T8083	26362-26367	SO_EXT:0000704	denotes	genes
T8084	26383-26394	CHEBI:16856	denotes	glutathione
T8085	26433-26438	SO_EXT:0000704	denotes	genes
T8086	26444-26455	GO_EXT:positive_regulation	denotes	upregulated
T8087	26461-26468	CHEBI_EXT:cadmium	denotes	cadmium
T8088	26489-26494	SO_EXT:0000704	denotes	genes
T8089	26499-26510	CHEBI_PR_EXT:thioredoxin	denotes	thioredoxin
T8090	26499-26520	GO_EXT:0004791	denotes	thioredoxin reductase
T8091	26499-26522	PR_EXT:000016871	denotes	thioredoxin reductase 1
T8092	26524-26530	PR_EXT:000016871	denotes	Txnrd1
T8093	26544-26552	MOP:0000569	denotes	reducing
T8094	26553-26560	CHEBI_GO_SO_EXT:enzyme	denotes	enzymes
T8095	26568-26579	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T8096	26572-26579	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T8097	26580-26591	CHEBI_PR_EXT:thioredoxin	denotes	thioredoxin
T8098	26598-26653	PR_EXT:000009274	denotes	KDEL endoplasmic reticulum protein retention receptor 2
T8099	26603-26624	GO:0005783	denotes	endoplasmic reticulum
T8100	26603-26642	GO:0035437	denotes	endoplasmic reticulum protein retention
T8101	26625-26632	CHEBI_PR_EXT:protein	denotes	protein
T8102	26643-26651	GO_EXT:0004872	denotes	receptor
T8103	26655-26661	PR_EXT:000009274	denotes	Kdelr2
T8104	26680-26682	GO:0005783	denotes	ER
T8105	26690-26698	GO_EXT:reaction_or_response	denotes	response
T8106	26718-26727	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T8107	26728-26756	PR_EXT:000004621	denotes	Bcl2-associated athanogene 3
T8108	26758-26762	PR_EXT:000004621	denotes	Bag3
T8109	26791-26800	GO:0006915	denotes	apoptosis
T9334	26855-26863	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T9335	26867-26871	PR_EXT:000010717	denotes	Mtf1
T9336	26879-26884	UBERON:0002107	denotes	liver
T9337	26888-26893	UBERON:0007023	denotes	adult
T9338	26895-26897	CHEBI:76777	denotes	pI
T9339	26898-26900	CHEBI_EXT:polyC_acid	denotes	pC
T9340	26909-26913	PR_EXT:000010717	denotes	Mtf1
T9341	26913-26915	PR_EXT:000010788	denotes	Mx
T9342	26920-26924	NCBITaxon:10088	denotes	mice
T9343	26983-26987	NCBITaxon:10088	denotes	mice
T9344	27033-27038	PR_EXT:000010717	denotes	MTF-1
T9345	27061-27066	UBERON:0007023	denotes	adult
T9346	27067-27072	UBERON:0002107	denotes	liver
T9347	27116-27125	UBERON:0000922	denotes	embryonic
T9348	27116-27125	_FRAGMENT	denotes	embryonic
T9349	27132-27143	GO:0009790	denotes	development
T9350	27126-27131	UBERON:0002107	denotes	liver
T9351	27126-27143	GO:0001889	denotes	liver development
T9352	27168-27172	SO_EXT:0000704	denotes	gene
T9353	27168-27183	GO:0010467	denotes	gene expression
T9354	27187-27193	UBERON:0002107	denotes	livers
T9355	27206-27213	CHEBI_EXT:cadmium	denotes	cadmium
T9356	27222-27226	PR_EXT:000010717	denotes	Mtf1
T9357	27226-27228	PR_EXT:000010788	denotes	Mx
T9358	27237-27241	PR_EXT:000010717	denotes	Mtf1
T9359	27241-27245	SO_EXT:0000346	denotes	loxP
T9360	27246-27250	NCBITaxon:10088	denotes	mice
T9361	27268-27273	PR_EXT:000010717	denotes	MTF-1
T9362	27281-27285	SO_EXT:0000704	denotes	gene
T9363	27298-27309	SO_EXT:0000673	denotes	Transcripts
T9364	27355-27360	SO_EXT:0000704	denotes	genes
T9365	27361-27364	PR_EXT:000010925	denotes	Mt1
T9366	27369-27372	PR_EXT:000010704	denotes	Mt2
T9367	27428-27433	PR_EXT:000010717	denotes	MTF-1
T9368	27453-27458	CHEBI_EXT:metal	denotes	metal
T9369	27467-27477	GO:0010467	denotes	expression
T9370	27535-27540	SO_EXT:0000704	denotes	genes
T9371	27544-27549	PR_EXT:000014662	denotes	Sepw1
T9372	27561-27570	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T9373	27583-27588	PR_EXT:000014662	denotes	SEPW1
T9374	27589-27596	CHEBI_PR_EXT:protein	denotes	protein
T9375	27631-27642	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T9376	27635-27642	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T9377	27683-27687	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T9378	27688-27699	CHEBI:16856	denotes	glutathione
T9379	27739-27749	GO:0010467	denotes	expression
T9380	27753-27758	NCBITaxon:10088	denotes	mouse
T9381	27759-27764	PR_EXT:000014662	denotes	Sepw1
T9382	27773-27778	CL_GO_EXT:cell	denotes	cells
T9383	27792-27809	CHEBI:16240	denotes	hydrogen peroxide
T9384	27850-27857	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9385	27858-27869	CHEBI:16856	denotes	glutathione
T9386	27922-27932	GO:0010467	denotes	expression
T9387	27947-27951	SO_EXT:0000704	denotes	gene
T9388	27952-27957	SO_EXT:sequence_fusion_process	denotes	fused
T9389	27963-27966	NCBITaxon:10114	denotes	rat
T9390	27967-27972	PR_EXT:000014662	denotes	Sepw1
T9391	27973-27981	SO_EXT:0000167	denotes	promoter
T9392	28009-28012	NCBITaxon:10114	denotes	rat
T9393	28013-28024	CL:0000125	denotes	glial cells
T9394	28019-28024	CL_GO_EXT:cell	denotes	cells
T9395	28028-28034	CHEBI_EXT:copper	denotes	copper
T9396	28039-28043	CHEBI_EXT:zinc	denotes	zinc
T9397	28053-28060	CHEBI_EXT:cadmium	denotes	cadmium
T9398	28067-28075	GO_EXT:reaction_or_response	denotes	response
T9399	28108-28116	SO_EXT:sequence_inversion_process	denotes	inverted
T9400	28121-28129	SO_EXT:biological_sequence	denotes	sequence
T9401	28154-28157	NCBITaxon:10114	denotes	rat
T9402	28158-28163	PR_EXT:000014662	denotes	Sepw1
T9403	28164-28183	GO_SO_EXT:transcriptional_start_entity_or_process	denotes	transcription start
T9404	28240-28245	PR_EXT:000010717	denotes	MTF-1
T9405	28246-28253	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9406	28262-28270	SO_EXT:biological_sequence	denotes	sequence
T9407	28281-28291	GO:0010467	denotes	expression
T9408	28296-28299	CHEBI_SO_EXT:DNA	denotes	DNA
T9409	28300-28307	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9410	28338-28343	PR_EXT:000010717	denotes	MTF-1
T9411	28371-28381	GO:0010467	denotes	expression
T9412	28385-28390	NCBITaxon:10088	denotes	mouse
T9413	28391-28396	PR_EXT:000014662	denotes	Sepw1
T9414	28400-28407	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9415	28441-28449	SO_EXT:sequence_inversion_process	denotes	inverted
T9416	28454-28462	SO_EXT:biological_sequence	denotes	sequence
T9417	28464-28469	PR_EXT:000011059	denotes	Ndrg1
T9418	28491-28496	PR_EXT:000010717	denotes	MTF-1
T9419	28504-28508	SO_EXT:0000704	denotes	gene
T9420	28519-28552	PR_EXT:000011059	denotes	N-myc downstream regulated gene 1
T9421	28536-28545	GO:0065007	denotes	regulated
T9422	28546-28550	SO_EXT:0000704	denotes	gene
T9423	28586-28599	GO_EXT:transcription	denotes	transcription
T9424	28586-28606	GO_EXT:transcription_factor	denotes	transcription factor
T9425	28607-28612	PR_EXT:000010812	denotes	N-myc
T9426	28627-28637	GO:0010467	denotes	expression
T9427	28641-28646	NCBITaxon:10088	denotes	mouse
T9428	28647-28652	PR_EXT:000011059	denotes	Ndrg1
T9429	28659-28672	GO_EXT:transcription	denotes	Transcription
T9430	28676-28681	PR_EXT:000011059	denotes	Ndrg1
T9431	28693-28698	NCBITaxon:9606	denotes	human
T9432	28699-28707	SO_EXT:0000855	denotes	ortholog
T9433	28732-28745	GO_PATO_EXT:physiological_process_or_quality	denotes	physiological
T9434	28750-28754	CL_GO_EXT:cell	denotes	cell
T9435	28782-28791	CHEBI_EXT:50113	denotes	androgens
T9436	28793-28799	CHEBI_EXT:nickel	denotes	nickel
T9437	28800-28809	CHEBI:36357	denotes	compounds
T9438	28811-28814	CHEBI_SO_EXT:DNA	denotes	DNA
T9439	28866-28873	CHEBI_PR_EXT:protein	denotes	protein
T9440	28881-28890	GO:0010467	denotes	expressed
T9441	28894-28899	NCBITaxon:9606	denotes	human
T9442	28916-28923	UBERON:0000479	denotes	tissues
T9443	28933-28937	UBERON:0002048	denotes	lung
T9444	28939-28944	UBERON:0002107	denotes	liver
T9445	28946-28951	UBERON:0000955	denotes	brain
T9446	28953-28959	UBERON:0000310	denotes	breast
T9447	28961-28967	UBERON:0002113	denotes	kidney
T9448	28972-28976	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T9449	28992-28997	PR_EXT:000011059	denotes	Ndrg1
T9450	29017-29022	NCBITaxon:9606	denotes	human
T9451	29023-29031	SO_EXT:0000855	denotes	ortholog
T9452	29136-29142	CHEBI_EXT:nickel	denotes	nickel
T9453	29186-29190	CL_GO_EXT:cell	denotes	cell
T9454	29186-29190	_FRAGMENT	denotes	cell
T9455	29198-29206	GO:0051716	denotes	response
T9456	29261-29266	PR_EXT:000011059	denotes	Ndrg1
T9457	29267-29271	SO_EXT:0000704	denotes	gene
T9458	29267-29282	GO:0010467	denotes	gene expression
T9459	29302-29309	CHEBI_EXT:cadmium	denotes	cadmium
T9460	29320-29325	PR_EXT:000010717	denotes	MTF-1
T9461	29381-29386	PR_EXT:000005958	denotes	Csrp1
T9462	29388-29398	GO:0010467	denotes	expression
T9463	29412-29415	CHEBI_SO_EXT:DNA	denotes	DNA
T9464	29416-29423	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9465	29446-29451	PR_EXT:000010717	denotes	MTF-1
T9466	29468-29475	CHEBI_EXT:cadmium	denotes	cadmium
T9467	29489-29496	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9468	29507-29515	SO_EXT:sequence_upstreamness	denotes	upstream
T9469	29523-29542	GO_SO_EXT:transcriptional_start_entity_or_process	denotes	transcription start
T9470	29557-29562	NCBITaxon:9606	denotes	human
T9471	29564-29569	NCBITaxon:8782	denotes	avian
T9472	29574-29581	NCBITaxon:9031	denotes	chicken
T9473	29582-29587	PR_EXT:000005958	denotes	CSRP1
T9474	29609-29616	CHEBI_PR_EXT:protein	denotes	protein
T9475	29620-29629	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T9476	29633-29641	GO_PATO_EXT:biological_adhesion_or_attachedness	denotes	adhesion
T9477	29633-29649	GO:0070161	denotes	adhesion plaques
T9478	29674-29691	GO:0031941	denotes	filamentous actin
T9479	29716-29724	GO_PATO_EXT:biological_adhesion_or_attachedness	denotes	adhesion
T9480	29716-29731	GO:0070161	denotes	adhesion plaque
T9481	29732-29739	CHEBI_PR_EXT:protein	denotes	protein
T9482	29740-29745	PR_EXT:000018242	denotes	zyxin
T9483	29762-29781	GO:0051764	denotes	actin-cross-linking
T9484	29782-29789	CHEBI_PR_EXT:protein	denotes	protein
T9485	29828-29832	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T9486	29867-29879	GO:0005856	denotes	cytoskeletal
T9487	29911-29925	CL:0000010	denotes	cultured cells
T9488	29920-29925	CL_GO_EXT:cell	denotes	cells
T9489	29929-29936	CHEBI_EXT:cadmium	denotes	cadmium
T9490	29963-29987	_FRAGMENT	denotes	destruction of, cellular
T9491	29996-30004	GO:0044257	denotes	proteins
T9492	29979-29987	CL_GO_EXT:cell	denotes	cellular
T9493	29996-30004	CHEBI_PR_EXT:protein	denotes	proteins
T9494	30013-30031	GO:0015629	denotes	actin cytoskeleton
T9495	30061-30066	CL_GO_EXT:cell	denotes	cells
T9496	30074-30077	NCBITaxon:10114	denotes	rat
T9497	30078-30084	UBERON:0002113	denotes	kidney
T9498	30118-30132	GO:0051017	denotes	actin-bundling
T9499	30133-30140	CHEBI_PR_EXT:protein	denotes	protein
T9500	30141-30147	PR_EXT:000017296	denotes	villin
T9501	30165-30172	CHEBI_EXT:cadmium	denotes	cadmium
T9502	30215-30231	MOP:0000630	denotes	depolymerization
T9503	30215-30247	GO:0007019	denotes	depolymerization of microtubules
T9504	30235-30247	GO:0005874	denotes	microtubules
T9505	30268-30273	PR_EXT:000005958	denotes	CSRP1
T9506	30311-30332	GO:0044430	denotes	cytoskeletal elements
T9507	30340-30345	NCBITaxon:10088	denotes	mouse
T9508	30351-30363	GO_EXT:positive_regulation	denotes	upregulation
T9509	30367-30374	CHEBI_EXT:cadmium	denotes	cadmium
T9510	30393-30401	NCBITaxon:1	denotes	organism
T9511	30421-30433	GO:0005856	denotes	cytoskeleton
T9512	30477-30482	PR_EXT:000010717	denotes	MTF-1
T9513	30493-30501	GO_EXT:reaction_or_response	denotes	response
T9514	30507-30517	GO:0010467	denotes	expression
T9515	30544-30549	PR_EXT:000010717	denotes	MTF-1
T9516	30566-30579	GO_EXT:transcription	denotes	transcription
T9517	30583-30591	PR_EXT:000015124	denotes	Slc39a10
T9518	30638-30648	GO:0010467	denotes	expression
T9519	30665-30670	SO_EXT:0000704	denotes	genes
T9520	30676-30679	PR_EXT:000010925	denotes	Mt1
T9521	30681-30684	PR_EXT:000010704	denotes	Mt2
T9522	30690-30694	PR_EXT:000015073	denotes	Znt1
T9523	30703-30711	PR_EXT:000015124	denotes	SLC39A10
T9524	30725-30730	NCBITaxon:10088	denotes	mouse
T9525	30780-30785	CHEBI_EXT:metal	denotes	metal
T9526	30780-30802	GO_EXT:0046873	denotes	metal ion transporters
T9527	30786-30789	CHEBI:24870	denotes	ion
T9528	30790-30802	GO_EXT:biological_mover_or_transporter	denotes	transporters
T9529	30872-30885	GO:0005622	denotes	intracellular
T9530	30877-30885	CL_GO_EXT:cell	denotes	cellular
T9531	30886-30897	GO:0005737	denotes	cytoplasmic
T9532	30898-30903	CHEBI_EXT:metal	denotes	metal
T9533	30904-30907	CHEBI:24870	denotes	ion
T9534	30936-30949	GO:0005576	denotes	extracellular
T9535	30936-30949	_FRAGMENT	denotes	extracellular
T9536	30968-30977	GO:0006858	denotes	transport
T9537	30941-30949	CL_GO_EXT:cell	denotes	cellular
T9538	30954-30963	GO:0031982	denotes	vesicular
T9539	30954-30963	_FRAGMENT	denotes	vesicular
T9540	30968-30977	GO:0016192	denotes	transport
T9541	30964-30967	CHEBI:24870	denotes	ion
T9542	30964-30977	GO:0006811	denotes	ion transport
T9543	30987-30996	GO:0005737	denotes	cytoplasm
T9544	31002-31010	CHEBI_PR_EXT:protein	denotes	proteins
T9545	31036-31048	GO_EXT:biological_mover_or_transporter	denotes	transporters
T9546	31052-31056	CHEBI_EXT:zinc	denotes	zinc
T9547	31058-31062	CHEBI_EXT:iron	denotes	iron
T9548	31064-31073	CHEBI_EXT:manganese	denotes	manganese
T9549	31081-31088	CHEBI_EXT:cadmium	denotes	cadmium
T9550	31110-31118	PR_EXT:000015124	denotes	SLC39A10
T9551	31203-31207	CHEBI_EXT:zinc	denotes	zinc
T9552	31208-31219	GO_EXT:biological_mover_or_transporter	denotes	transporter
T9553	31255-31260	PR_EXT:000010717	denotes	MTF-1
T9554	31289-31299	GO:0010467	denotes	expression
T9555	31304-31309	CHEBI_EXT:metal	denotes	metal
T9556	31327-31332	NCBITaxon:10088	denotes	mouse
T9557	31333-31337	PR_EXT:000015073	denotes	Znt1
T9558	31338-31342	SO_EXT:0000704	denotes	gene
T9559	31353-31361	CHEBI_PR_EXT:protein	denotes	proteins
T9560	31394-31406	GO_EXT:biological_mover_or_transporter	denotes	transporters
T9561	31419-31432	GO:0005622	denotes	intracellular
T9562	31424-31432	CL_GO_EXT:cell	denotes	cellular
T9563	31433-31444	GO:0005737	denotes	cytoplasmic
T9564	31445-31449	CHEBI_EXT:zinc	denotes	zinc
T9565	31463-31467	CHEBI_EXT:zinc	denotes	zinc
T9566	31480-31485	CL_GO_EXT:cell	denotes	cells
T9567	31494-31507	GO:0005622	denotes	intracellular
T9568	31499-31507	CL_GO_EXT:cell	denotes	cellular
T9569	31508-31516	GO:0031982	denotes	vesicles
T9570	31563-31567	CHEBI_EXT:zinc	denotes	zinc
T9571	31616-31624	CL_GO_EXT:cell	denotes	cellular
T9572	31616-31624	_FRAGMENT	denotes	cellular
T9573	31630-31641	GO:0019725	denotes	homeostasis
T9574	31625-31629	CHEBI_EXT:zinc	denotes	zinc
T9575	31662-31670	PR_EXT:000015124	denotes	SLC39A10
T9576	31683-31687	CHEBI_EXT:zinc	denotes	zinc
T9577	31688-31699	GO_EXT:biological_mover_or_transporter	denotes	transporter
T9578	31701-31706	PR_EXT:000010717	denotes	MTF-1
T9579	31713-31720	GO:0065007	denotes	control
T9580	31721-31731	GO:0010467	denotes	expression
T9581	31739-31743	CHEBI_EXT:zinc	denotes	zinc
T9582	31744-31756	GO_EXT:biological_mover_or_transporter	denotes	transporters
T9583	31794-31798	PR_EXT:000015073	denotes	Znt1
T9584	31803-31811	PR_EXT:000015124	denotes	Slc39a10
T9585	31822-31829	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9586	31833-31838	PR_EXT:000010717	denotes	MTF-1
T9587	31876-31886	SO_EXT:sequence_downstreamness	denotes	downstream
T9588	31894-31902	PR_EXT:000015124	denotes	Slc39a10
T9589	31903-31922	GO_SO_EXT:transcriptional_start_entity_or_process	denotes	transcription start
T9590	31950-31957	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9591	32004-32025	GO_SO_EXT:transcriptional_start_entity_or_process	denotes	transcriptional start
T9592	32004-32030	SO_EXT:0000315	denotes	transcriptional start site
T9593	32035-32038	CHEBI_SO_EXT:RNA	denotes	RNA
T9594	32035-32052	GO_EXT:0001055	denotes	RNA polymerase II
T9595	32068-32081	GO_EXT:transcription	denotes	transcription
T9596	32068-32089	GO_EXT:transcription_factor	denotes	transcription factors
T9597	32107-32120	GO_EXT:transcription	denotes	transcription
T9598	32139-32143	SO_EXT:0000704	denotes	gene
T9599	32192-32197	NCBITaxon_EXT:yeast	denotes	yeast
T9600	32206-32210	CHEBI_EXT:zinc	denotes	zinc
T9601	32206-32241	PR_EXT:P47043	denotes	zinc-responsive activator protein 1
T9602	32232-32239	CHEBI_PR_EXT:protein	denotes	protein
T9603	32243-32247	PR_EXT:P47043	denotes	Zap1
T9604	32264-32268	SO_EXT:0000704	denotes	gene
T9605	32270-32274	CHEBI_EXT:zinc	denotes	zinc
T9606	32270-32298	PR_EXT:Q12436	denotes	zinc-regulated transporter 2
T9607	32275-32284	GO:0065007	denotes	regulated
T9608	32285-32296	GO_EXT:biological_mover_or_transporter	denotes	transporter
T9609	32300-32304	PR_EXT:Q12436	denotes	ZRT2
T9610	32339-32347	PR_EXT:000015124	denotes	Slc39a10
T9611	32348-32358	GO:0010467	denotes	expression
T9612	32362-32367	PR_EXT:000010717	denotes	MTF-1
T9613	32416-32424	SO_EXT:0000167	denotes	promoter
T9614	32425-32432	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9615	32449-32454	PR_EXT:000010717	denotes	MTF-1
T9616	32456-32463	CHEBI_EXT:cadmium	denotes	cadmium
T9617	32488-32502	GO_EXT:negative_regulation	denotes	downregulation
T9618	32506-32514	PR_EXT:000015124	denotes	Slc39a10
T9619	32515-32526	SO_EXT:0000673	denotes	transcripts
T9620	32580-32588	GO_EXT:reaction_or_response	denotes	response
T9621	32608-32612	SO_EXT:0000704	denotes	gene
T9622	32624-32629	PR_EXT:000010717	denotes	MTF-1
T9623	32635-32640	NCBITaxon:10088	denotes	mouse
T9624	32641-32648	UBERON:0000922	denotes	embryos
T9625	32665-32669	PR_EXT:000010717	denotes	Mtf1
T9626	32723-32728	SO_EXT:0000704	denotes	genes
T9627	32750-32767	PR_EXT:000003809	denotes	alpha-fetoprotein
T9628	32769-32772	PR_EXT:000003809	denotes	Afp
T9629	32782-32787	UBERON:0002107	denotes	liver
T9630	32797-32810	GO_EXT:transcription	denotes	transcription
T9631	32797-32817	GO_EXT:transcription_factor	denotes	transcription factor
T9632	32818-32823	SO_EXT:0000172	denotes	CCAAT
T9633	32818-32854	PR_EXT:000005307	denotes	CCAAT/enhancer binding protein alpha
T9634	32824-32832	SO_EXT:0000165	denotes	enhancer
T9635	32833-32840	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9636	32841-32848	CHEBI_PR_EXT:protein	denotes	protein
T9637	32856-32861	PR_EXT:000005307	denotes	Cebpa
T9638	32917-32930	GO:0001889	denotes	hepatogenesis
T9639	32932-32935	PR_EXT:000003809	denotes	Afp
T9640	32936-32946	GO:0010467	denotes	expression
T9641	32964-32971	GO:0007567	denotes	natally
T9642	32988-32995	PR_EXT:000003918	denotes	albumin
T9643	33012-33017	UBERON:0007023	denotes	adult
T9644	33018-33022	PR_EXT:000010717	denotes	Mtf1
T9645	33022-33024	PR_EXT:000010788	denotes	Mx
T9646	33029-33033	NCBITaxon:10088	denotes	mice
T9647	33042-33047	PR_EXT:000010717	denotes	MTF-1
T9648	33077-33080	PR_EXT:000003809	denotes	Afp
T9649	33081-33091	GO:0010467	denotes	expression
T9650	33093-33098	PR_EXT:000005307	denotes	Cebpa
T9651	33102-33111	GO:0010467	denotes	expressed
T9652	33119-33124	UBERON:0007023	denotes	adult
T9653	33125-33130	UBERON:0002107	denotes	liver
T9654	33151-33158	UBERON:0000479	denotes	tissues
T9655	33221-33231	GO:0010467	denotes	expression
T9656	33247-33253	UBERON:0002107	denotes	livers
T9657	33259-33264	UBERON:0007023	denotes	adult
T9658	33265-33269	PR_EXT:000010717	denotes	Mtf1
T9659	33269-33273	SO_EXT:0000346	denotes	loxP
T9660	33278-33282	PR_EXT:000010717	denotes	Mtf1
T9661	33282-33284	PR_EXT:000010788	denotes	Mx
T9662	33289-33293	NCBITaxon:10088	denotes	mice
T9663	33323-33328	PR_EXT:000010717	denotes	MTF-1
T9664	33340-33345	PR_EXT:000005307	denotes	Cebpa
T9665	33346-33356	GO:0010467	denotes	expression
T9666	33369-33378	UBERON:0000922	denotes	embryonal
T9667	33369-33390	GO:0009790	denotes	embryonal development
T9668	33500-33505	PR_EXT:000010717	denotes	MTF-1
T9669	33529-33537	GO_EXT:reaction_or_response	denotes	response
T9670	33538-33547	GO_EXT:regulator	denotes	regulator
T9671	33612-33617	SO_EXT:0000704	denotes	genes
T9672	33621-33626	PR_EXT:000010717	denotes	MTF-1
T9673	33634-33639	UBERON:0007023	denotes	adult
T9674	33640-33645	NCBITaxon:10088	denotes	mouse
T9675	33646-33651	UBERON:0002107	denotes	liver
T9676	33668-33673	PR_EXT:000014662	denotes	Sepw1
T9677	33675-33680	PR_EXT:000010717	denotes	MTF-1
T9678	33711-33721	GO:0010467	denotes	expression
T9679	33744-33749	NCBITaxon:10088	denotes	mouse
T9680	33750-33755	PR_EXT:000010717	denotes	MTF-1
T9681	33759-33768	MOP:0000568	denotes	oxidative
T9682	33776-33784	GO_EXT:reaction_or_response	denotes	response
T9683	33799-33804	PR_EXT:000010717	denotes	MTF-1
T9684	33824-33831	CHEBI_EXT:cadmium	denotes	cadmium
T9685	33840-33850	GO:0010467	denotes	expression
T9686	33854-33859	PR_EXT:000011059	denotes	Ndrg1
T9687	33864-33869	PR_EXT:000005958	denotes	Csrp1
T9688	33884-33889	PR_EXT:000010717	denotes	MTF-1
T9689	33917-33927	GO:0010467	denotes	expression
T9690	33931-33939	PR_EXT:000015124	denotes	Slc39a10
T9691	33968-33983	GO_EXT:transcription	denotes	transcriptional
T9692	33998-34003	SO_EXT:0000704	denotes	genes
T9693	34009-34012	PR_EXT:000010925	denotes	Mt1
T9694	34014-34017	PR_EXT:000010704	denotes	Mt2
T9695	34021-34025	PR_EXT:000015073	denotes	Znt1
T9696	34041-34054	GO_EXT:transcription	denotes	transcription
T9697	34041-34061	GO_EXT:transcription_factor	denotes	transcription factor
T9698	34134-34138	SO_EXT:0000704	denotes	gene
T9699	34158-34163	UBERON:0002107	denotes	liver
T9700	34164-34168	SO_EXT:0000704	denotes	gene
T9701	34164-34179	GO:0010467	denotes	gene expression
T9702	34183-34190	CHEBI_EXT:cadmium	denotes	cadmium
T9703	34209-34213	NCBITaxon:10088	denotes	mice
T9704	34240-34245	SO_EXT:0000704	denotes	genes
T9705	34270-34277	CHEBI_EXT:cadmium	denotes	cadmium
T9706	34330-34335	PR_EXT:000010717	denotes	MTF-1
T9707	34364-34401	GO:1903409	denotes	production of reactive oxygen species
T9708	34378-34401	CHEBI:26523	denotes	reactive oxygen species
T9709	34429-34436	CHEBI_EXT:cadmium	denotes	cadmium
T9710	34471-34485	CL:0000010	denotes	cultured cells
T9711	34480-34485	CL_GO_EXT:cell	denotes	cells
T9712	34489-34496	NCBITaxon:33208	denotes	animals
T9713	34500-34507	CHEBI_EXT:cadmium	denotes	cadmium
T9714	34540-34547	MOP:0000569	denotes	reduced
T9715	34540-34559	CHEBI:16856	denotes	reduced glutathione
T9716	34561-34566	CHEBI:18059	denotes	lipid
T9717	34584-34587	CHEBI_SO_EXT:DNA	denotes	DNA
T9718	34604-34613	MOP:0000568	denotes	Oxidative
T9719	34655-34663	CL_GO_EXT:cell	denotes	cellular
T9720	34655-34675	GO:0019725	denotes	cellular homeostasis
T9721	34706-34716	GO:0010467	denotes	expression
T9722	34720-34725	SO_EXT:0000704	denotes	genes
T9723	34726-34734	SO_EXT:sequence_coding_function	denotes	encoding
T9724	34735-34746	GO:0006953	denotes	acute-phase
T9725	34747-34755	CHEBI_PR_EXT:protein	denotes	proteins
T9726	34760-34771	CHEBI_GO_EXT:antioxidant	denotes	antioxidant
T9727	34764-34771	CHEBI_MOP_EXT:oxidising_agent_or_oxidation	denotes	oxidant
T9728	34772-34779	CHEBI_GO_SO_EXT:enzyme	denotes	enzymes
T9729	34789-34796	NCBITaxon:40674	denotes	mammals
T9762	35600-35608	_FRAGMENT	denotes	cellular
T9763	35617-35625	GO:0051716	denotes	response
T9764	35609-35616	CHEBI_EXT:cadmium	denotes	cadmium
T9765	35655-35662	CHEBI_EXT:cadmium	denotes	cadmium
T9766	35690-35695	NCBITaxon:10088	denotes	mouse
T9767	35696-35705	UBERON:0000922	denotes	embryonic
T9768	35706-35717	CL:0000057	denotes	fibroblasts
T9769	35740-35744	PR_EXT:000010717	denotes	Mtf1
T9770	35745-35753	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T9771	35771-35782	CHEBI:16856	denotes	glutathione
T9772	35822-35827	PR_EXT:000010717	denotes	MTF-1
T9773	35843-35848	SO_EXT:0000704	denotes	genes
T9774	35860-35867	MOP:0000569	denotes	reduced
T9775	35860-35879	CHEBI:16856	denotes	reduced glutathione
T9776	35902-35909	CHEBI_EXT:cadmium	denotes	cadmium
T9777	35910-35917	GO:0006952	denotes	defense
T9778	35981-35989	CL_GO_EXT:cell	denotes	cellular
T9779	35981-35989	_FRAGMENT	denotes	cellular
T9780	36003-36010	GO:0006968	denotes	defense
T9781	35995-36002	CHEBI_EXT:cadmium	denotes	cadmium
T9782	36020-36025	PR_EXT:000010717	denotes	MTF-1
T9783	36041-36046	SO_EXT:0000704	denotes	genes
T9784	36088-36099	CHEBI:16856	denotes	glutathione
T9785	36129-36134	PR_EXT:000014662	denotes	Sepw1
T2390	5035-5041	NCBITaxon:33208	denotes	Animal
T2391	5071-5075	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T2392	5076-5080	PR_EXT:000010717	denotes	Mtf1
T2393	5080-5084	SO_EXT:0000346	denotes	loxP
T2394	5085-5089	SO_EXT:0000346	denotes	loxP
T2395	5090-5094	NCBITaxon:10088	denotes	mice
T2396	5109-5111	PR_EXT:000010788	denotes	Mx
T2397	5116-5125	SO_EXT:0000902	denotes	transgene
T2398	5127-5131	PR_EXT:000010717	denotes	Mtf1
T2399	5131-5135	SO_EXT:0000346	denotes	loxP
T2400	5136-5140	SO_EXT:0000346	denotes	loxP
T2401	5141-5143	PR_EXT:000010788	denotes	Mx
T2402	5156-5160	PR_EXT:000010717	denotes	Mtf1
T2403	5160-5162	PR_EXT:000010788	denotes	Mx
T2404	5200-5209	SO_EXT:0000902	denotes	transgene
T2023	3897-3905	CHEBI:7507	denotes	neomycin
T9730	34798-34805	CHEBI_EXT:cadmium	denotes	cadmium
T9731	34833-34839	UBERON:0002113	denotes	kidney
T9732	34844-34849	UBERON:0002107	denotes	liver
T9733	34855-34862	CHEBI_EXT:cadmium	denotes	cadmium
T9734	34879-34886	GO:0032991	denotes	complex
T9735	34989-34998	MOP:0000568	denotes	oxidative
T9736	35047-35058	CHEBI:16856	denotes	glutathione
T9737	35093-35100	GO:0006952	denotes	defense
T9738	35109-35116	CHEBI_EXT:cadmium	denotes	cadmium
T9739	35132-35143	CHEBI:16856	denotes	Glutathione
T9740	35156-35165	GO:0065003	denotes	complexes
T9741	35166-35173	CHEBI_EXT:cadmium	denotes	cadmium
T9742	35193-35206	CHEBI:26519	denotes	free radicals
T9743	35217-35240	CHEBI:26523	denotes	reactive oxygen species
T9744	35270-35279	CHEBI_GO_SO_EXT:enzyme	denotes	enzymatic
T9745	35315-35326	CHEBI:16856	denotes	glutathione
T9746	35330-35338	MOP:0000568	denotes	oxidized
T9747	35368-35379	CHEBI:16856	denotes	glutathione
T9748	35368-35389	GO_PR_EXT:glutathione_disulfide_reductase	denotes	glutathione reductase
T9749	35397-35408	CHEBI:16856	denotes	glutathione
T9750	35397-35423	GO_PR_EXT:glutathione_S_transferase	denotes	glutathione-S-transferases
T9751	35409-35410	CHEBI_EXT:sulfur	denotes	S
T9752	35436-35447	MOP:0000779	denotes	conjugation
T9753	35476-35487	CHEBI:16856	denotes	glutathione
T9754	35502-35509	CHEBI_EXT:cadmium	denotes	cadmium
T9755	35518-35530	GO_EXT:positive_regulation	denotes	upregulation
T9756	35534-35538	PR_EXT:000007897	denotes	Gclc
T9757	35534-35538	GO_EXT:0004357	denotes	Gclc
T9758	35540-35543	GO_PR_EXT:glutathione_disulfide_reductase	denotes	Gsr
T9759	35548-35553	PR_EXT:000030257	denotes	Gstm4
T9760	35581-35592	CHEBI:16856	denotes	glutathione
T9761	35600-35608	CL_GO_EXT:cell	denotes	cellular
R1486	T2413	T2412	_lexicallyChainedTo	acid,polyinosinic
R2088	T3337	T3336	_lexicallyChainedTo	sequence,synthetic
R2794	T4225	T4224	_lexicallyChainedTo	cell,embryonic
R2938	T4613	T4612	_lexicallyChainedTo	beta,interferon
R4705	T7370	T7369	_lexicallyChainedTo	expression,downregulation of
R5031	T7992	T7991	_lexicallyChainedTo	glutathione,metabolism of
R5032	T8049	T8048	_lexicallyChainedTo	response,cellular
R5033	T8058	T8057	_lexicallyChainedTo	ligase,inhibitor of
R5555	T9349	T9348	_lexicallyChainedTo	development,embryonic
R5556	T9455	T9454	_lexicallyChainedTo	response,cell
R5557	T9491	T9490	_lexicallyChainedTo	proteins,"destruction of, cellular"
R5558	T9536	T9535	_lexicallyChainedTo	transport,extracellular
R5559	T9540	T9539	_lexicallyChainedTo	transport,vesicular
R5560	T9573	T9572	_lexicallyChainedTo	homeostasis,cellular
R5561	T9763	T9762	_lexicallyChainedTo	response,cellular
R5562	T9780	T9779	_lexicallyChainedTo	defense,cellular

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PMC:1253828 / 1840-38092 JSON TXT