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Using RT–PCRs (Figure 1b), a shortened product was obtained with RNA from Mtf1Mx-cre livers, indicating a successful excision of exons 3 and 4 of Mtf1 in these animals. On close examination, a very faint band similar in size to full-length signal was also observed in those mice, probably due to a low amount of residual full-length Mtf1 mRNA. The level of functional MTF-1 protein was examined by EMSA (Figure 1c): MTF-1 protein–DNA complex was detectable with liver protein extract from an Mtf1loxP control mouse, but no functional MRE-binding protein was observed with an Mtf1Mx-cre sample. Thus, deletion of exons 3 and 4 of Mtf1 in the liver of Mtf1Mx-cre mice was virtually complete. All examined liver-specific knockout mice were viable under laboratory conditions and appeared normal."}

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