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PMC:1253828 / 15118-15962 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T4692 0-5 VBG denotes Using
T4693 53-61 VBN denotes obtained
T4694 6-7 DT denotes a
T4695 33-41 NN denotes strategy
T4696 8-18 JJ denotes homologous
T4697 19-32 NN denotes recombination
T4698 41-43 , denotes ,
T4699 43-47 NNS denotes mice
T4700 48-52 VBD denotes were
T4701 62-66 IN denotes with
T4702 67-68 DT denotes a
T4703 90-98 NN denotes Mtf1loxP
T4704 69-77 VBN denotes modified
T4705 78-82 NN denotes Mtf1
T4706 83-89 NN denotes allele
T4707 99-104 WRB denotes where
T4708 189-196 VBN denotes flanked
T4709 105-110 NNS denotes exons
T4710 111-112 CD denotes 3
T4711 113-116 CC denotes and
T4712 117-118 CD denotes 4
T4713 118-120 , denotes ,
T4714 120-128 VBG denotes encoding
T4715 129-133 CD denotes four
T4716 134-136 IN denotes of
T4717 137-140 DT denotes the
T4718 150-157 NNS denotes fingers
T4719 141-144 CD denotes six
T4720 145-149 NN denotes zinc
T4721 158-160 IN denotes of
T4722 161-164 DT denotes the
T4723 177-183 NN denotes domain
T4724 165-168 NN denotes DNA
T4725 169-176 VBG denotes binding
T4726 168-169 HYPH denotes -
T4727 183-185 , denotes ,
T4728 185-188 VBP denotes are
T4729 197-199 IN denotes by
T4730 200-204 NN denotes loxP
T4731 205-210 NNS denotes sites
T4732 211-212 -LRB- denotes (
T4733 219-221 NN denotes 1a
T4734 212-218 NN denotes Figure
T4735 221-222 -RRB- denotes )
T4736 222-223 . denotes .
T4737 223-344 sentence denotes Mice homozygous for the Mtf1loxP allele were further crossed with animals of the Cre recombinase transgenic line Mx-cre.
T4738 224-228 NNS denotes Mice
T4739 277-284 VBN denotes crossed
T4740 229-239 JJ denotes homozygous
T4741 240-243 IN denotes for
T4742 244-247 DT denotes the
T4743 257-263 NN denotes allele
T4744 248-256 NN denotes Mtf1loxP
T4745 264-268 VBD denotes were
T4746 269-276 RB denotes further
T4747 285-289 IN denotes with
T4748 290-297 NNS denotes animals
T4749 298-300 IN denotes of
T4750 301-304 DT denotes the
T4751 332-336 NN denotes line
T4752 305-308 NN denotes Cre
T4753 309-320 NN denotes recombinase
T4754 321-331 JJ denotes transgenic
T4755 337-339 NN denotes Mx
T4756 340-343 NN denotes cre
T4757 339-340 HYPH denotes -
T4758 343-344 . denotes .
T4759 344-547 sentence denotes Cre recombinase is expressed in this line under the control of the mouse Mx1 gene promoter, which is inducible by administration of interferon alpha or beta, or synthetic double-stranded RNA pI–pC (32).
T4760 345-348 NN denotes Cre
T4761 349-360 NN denotes recombinase
T4762 364-373 VBN denotes expressed
T4763 361-363 VBZ denotes is
T4764 374-376 IN denotes in
T4765 377-381 DT denotes this
T4766 382-386 NN denotes line
T4767 387-392 IN denotes under
T4768 393-396 DT denotes the
T4769 397-404 NN denotes control
T4770 405-407 IN denotes of
T4771 408-411 DT denotes the
T4772 427-435 NN denotes promoter
T4773 412-417 NN denotes mouse
T4774 418-421 NN denotes Mx1
T4775 422-426 NN denotes gene
T4776 435-437 , denotes ,
T4777 437-442 WDT denotes which
T4778 443-445 VBZ denotes is
T4779 446-455 JJ denotes inducible
T4780 456-458 IN denotes by
T4781 459-473 NN denotes administration
T4782 474-476 IN denotes of
T4783 477-487 NN denotes interferon
T4784 488-493 NN denotes alpha
T4785 494-496 CC denotes or
T4786 497-501 NN denotes beta
T4787 501-503 , denotes ,
T4788 503-505 CC denotes or
T4789 506-515 JJ denotes synthetic
T4790 539-541 NN denotes pC
T4791 516-522 JJ denotes double
T4792 523-531 VBN denotes stranded
T4793 522-523 HYPH denotes -
T4794 532-535 NN denotes RNA
T4795 536-538 NN denotes pI
T4796 538-539 HYPH denotes –
T4797 542-543 -LRB- denotes (
T4798 543-545 CD denotes 32
T4799 545-546 -RRB- denotes )
T4800 546-547 . denotes .
T4801 547-691 sentence denotes Cre-mediated deletion was reported to be complete in the liver, while varying in other tissues, ranging from 94% in spleen to 8% in brain (32).
T4802 548-551 NN denotes Cre
T4803 552-560 VBN denotes mediated
T4804 551-552 HYPH denotes -
T4805 561-569 NN denotes deletion
T4806 574-582 VBN denotes reported
T4807 570-573 VBD denotes was
T4808 583-585 TO denotes to
T4809 586-588 VB denotes be
T4810 589-597 JJ denotes complete
T4811 598-600 IN denotes in
T4812 601-604 DT denotes the
T4813 605-610 NN denotes liver
T4814 610-612 , denotes ,
T4815 612-617 IN denotes while
T4816 618-625 VBG denotes varying
T4817 626-628 IN denotes in
T4818 629-634 JJ denotes other
T4819 635-642 NNS denotes tissues
T4820 642-644 , denotes ,
T4821 644-651 VBG denotes ranging
T4822 652-656 IN denotes from
T4823 657-659 CD denotes 94
T4824 659-660 NN denotes %
T4825 661-663 IN denotes in
T4826 664-670 NN denotes spleen
T4827 671-673 IN denotes to
T4828 674-675 CD denotes 8
T4829 675-676 NN denotes %
T4830 677-679 IN denotes in
T4831 680-685 NN denotes brain
T4832 686-687 -LRB- denotes (
T4833 687-689 CD denotes 32
T4834 689-690 -RRB- denotes )
T4835 690-691 . denotes .
T4836 691-844 sentence denotes After Cre-mediated deletion of exons 3 and 4, which results in a frameshift and premature translation stop, no functional MTF-1 protein can be produced.
T4837 692-697 IN denotes After
T4838 835-843 VBN denotes produced
T4839 698-701 NN denotes Cre
T4840 702-710 VBN denotes mediated
T4841 701-702 HYPH denotes -
T4842 711-719 NN denotes deletion
T4843 720-722 IN denotes of
T4844 723-728 NNS denotes exons
T4845 729-730 CD denotes 3
T4846 731-734 CC denotes and
T4847 735-736 CD denotes 4
T4848 736-738 , denotes ,
T4849 738-743 WDT denotes which
T4850 744-751 VBZ denotes results
T4851 752-754 IN denotes in
T4852 755-756 DT denotes a
T4853 794-798 NN denotes stop
T4854 757-767 NN denotes frameshift
T4855 768-771 CC denotes and
T4856 772-781 JJ denotes premature
T4857 782-793 NN denotes translation
T4858 798-800 , denotes ,
T4859 800-802 DT denotes no
T4860 820-827 NN denotes protein
T4861 803-813 JJ denotes functional
T4862 814-817 NN denotes MTF
T4863 817-818 HYPH denotes -
T4864 818-819 CD denotes 1
T4865 828-831 MD denotes can
T4866 832-834 VB denotes be
T4867 843-844 . denotes .
R2950 T4692 T4693 advcl Using,obtained
R2951 T4694 T4695 det a,strategy
R2952 T4695 T4692 dobj strategy,Using
R2953 T4696 T4695 amod homologous,strategy
R2954 T4697 T4695 compound recombination,strategy
R2955 T4698 T4693 punct ", ",obtained
R2956 T4699 T4693 nsubjpass mice,obtained
R2957 T4700 T4693 auxpass were,obtained
R2958 T4701 T4693 prep with,obtained
R2959 T4702 T4703 det a,Mtf1loxP
R2960 T4703 T4701 pobj Mtf1loxP,with
R2961 T4704 T4703 amod modified,Mtf1loxP
R2962 T4705 T4703 compound Mtf1,Mtf1loxP
R2963 T4706 T4703 compound allele,Mtf1loxP
R2964 T4707 T4708 advmod where,flanked
R2965 T4708 T4693 advcl flanked,obtained
R2966 T4709 T4710 nmod exons,3
R2967 T4710 T4708 nsubjpass 3,flanked
R2968 T4711 T4710 cc and,3
R2969 T4712 T4710 conj 4,3
R2970 T4713 T4710 punct ", ",3
R2971 T4714 T4710 acl encoding,3
R2972 T4715 T4714 dobj four,encoding
R2973 T4716 T4715 prep of,four
R2974 T4717 T4718 det the,fingers
R2975 T4718 T4716 pobj fingers,of
R2976 T4719 T4718 nummod six,fingers
R2977 T4720 T4718 compound zinc,fingers
R2978 T4721 T4718 prep of,fingers
R2979 T4722 T4723 det the,domain
R2980 T4723 T4721 pobj domain,of
R2981 T4724 T4725 npadvmod DNA,binding
R2982 T4725 T4723 amod binding,domain
R2983 T4726 T4725 punct -,binding
R2984 T4727 T4708 punct ", ",flanked
R2985 T4728 T4708 auxpass are,flanked
R2986 T4729 T4708 agent by,flanked
R2987 T4730 T4731 compound loxP,sites
R2988 T4731 T4729 pobj sites,by
R2989 T4732 T4733 punct (,1a
R2990 T4733 T4708 parataxis 1a,flanked
R2991 T4734 T4733 compound Figure,1a
R2992 T4735 T4733 punct ),1a
R2993 T4736 T4693 punct .,obtained
R2994 T4738 T4739 nsubjpass Mice,crossed
R2995 T4740 T4738 amod homozygous,Mice
R2996 T4741 T4740 prep for,homozygous
R2997 T4742 T4743 det the,allele
R2998 T4743 T4741 pobj allele,for
R2999 T4744 T4743 compound Mtf1loxP,allele
R3000 T4745 T4739 auxpass were,crossed
R3001 T4746 T4739 advmod further,crossed
R3002 T4747 T4739 prep with,crossed
R3003 T4748 T4747 pobj animals,with
R3004 T4749 T4748 prep of,animals
R3005 T4750 T4751 det the,line
R3006 T4751 T4749 pobj line,of
R3007 T4752 T4753 nmod Cre,recombinase
R3008 T4753 T4751 nmod recombinase,line
R3009 T4754 T4751 amod transgenic,line
R3010 T4755 T4756 compound Mx,cre
R3011 T4756 T4751 appos cre,line
R3012 T4757 T4756 punct -,cre
R3013 T4758 T4739 punct .,crossed
R3014 T4760 T4761 compound Cre,recombinase
R3015 T4761 T4762 nsubjpass recombinase,expressed
R3016 T4763 T4762 auxpass is,expressed
R3017 T4764 T4762 prep in,expressed
R3018 T4765 T4766 det this,line
R3019 T4766 T4764 pobj line,in
R3020 T4767 T4762 prep under,expressed
R3021 T4768 T4769 det the,control
R3022 T4769 T4767 pobj control,under
R3023 T4770 T4769 prep of,control
R3024 T4771 T4772 det the,promoter
R3025 T4772 T4770 pobj promoter,of
R3026 T4773 T4772 compound mouse,promoter
R3027 T4774 T4772 compound Mx1,promoter
R3028 T4775 T4772 compound gene,promoter
R3029 T4776 T4772 punct ", ",promoter
R3030 T4777 T4778 dep which,is
R3031 T4778 T4772 relcl is,promoter
R3032 T4779 T4778 acomp inducible,is
R3033 T4780 T4779 prep by,inducible
R3034 T4781 T4780 pobj administration,by
R3035 T4782 T4781 prep of,administration
R3036 T4783 T4784 compound interferon,alpha
R3037 T4784 T4782 pobj alpha,of
R3038 T4785 T4784 cc or,alpha
R3039 T4786 T4784 conj beta,alpha
R3040 T4787 T4784 punct ", ",alpha
R3041 T4788 T4784 cc or,alpha
R3042 T4789 T4790 amod synthetic,pC
R3043 T4790 T4784 conj pC,alpha
R3044 T4791 T4792 amod double,stranded
R3045 T4792 T4790 amod stranded,pC
R3046 T4793 T4792 punct -,stranded
R3047 T4794 T4790 compound RNA,pC
R3048 T4795 T4790 compound pI,pC
R3049 T4796 T4790 punct –,pC
R3050 T4797 T4798 punct (,32
R3051 T4798 T4778 parataxis 32,is
R3052 T4799 T4798 punct ),32
R3053 T4800 T4762 punct .,expressed
R3054 T4802 T4803 npadvmod Cre,mediated
R3055 T4803 T4805 amod mediated,deletion
R3056 T4804 T4803 punct -,mediated
R3057 T4805 T4806 nsubjpass deletion,reported
R3058 T4807 T4806 auxpass was,reported
R3059 T4808 T4809 aux to,be
R3060 T4809 T4806 xcomp be,reported
R3061 T4810 T4809 acomp complete,be
R3062 T4811 T4809 prep in,be
R3063 T4812 T4813 det the,liver
R3064 T4813 T4811 pobj liver,in
R3065 T4814 T4809 punct ", ",be
R3066 T4815 T4816 mark while,varying
R3067 T4816 T4809 advcl varying,be
R3068 T4817 T4816 prep in,varying
R3069 T4818 T4819 amod other,tissues
R3070 T4819 T4817 pobj tissues,in
R3071 T4820 T4816 punct ", ",varying
R3072 T4821 T4816 advcl ranging,varying
R3073 T4822 T4821 prep from,ranging
R3074 T4823 T4824 nummod 94,%
R3075 T4824 T4822 pobj %,from
R3076 T4825 T4824 prep in,%
R3077 T4826 T4825 pobj spleen,in
R3078 T4827 T4822 prep to,from
R3079 T4828 T4829 nummod 8,%
R3080 T4829 T4827 pobj %,to
R3081 T4830 T4829 prep in,%
R3082 T4831 T4830 pobj brain,in
R3083 T4832 T4833 punct (,32
R3084 T4833 T4816 parataxis 32,varying
R3085 T4834 T4833 punct ),32
R3086 T4835 T4806 punct .,reported
R3087 T4837 T4838 prep After,produced
R3088 T4839 T4840 npadvmod Cre,mediated
R3089 T4840 T4842 amod mediated,deletion
R3090 T4841 T4840 punct -,mediated
R3091 T4842 T4837 pobj deletion,After
R3092 T4843 T4842 prep of,deletion
R3093 T4844 T4845 nmod exons,3
R3094 T4845 T4843 pobj 3,of
R3095 T4846 T4845 cc and,3
R3096 T4847 T4845 conj 4,3
R3097 T4848 T4842 punct ", ",deletion
R3098 T4849 T4850 dep which,results
R3099 T4850 T4842 relcl results,deletion
R3100 T4851 T4850 prep in,results
R3101 T4852 T4853 det a,stop
R3102 T4853 T4851 pobj stop,in
R3103 T4854 T4853 nmod frameshift,stop
R3104 T4855 T4854 cc and,frameshift
R3105 T4856 T4857 amod premature,translation
R3106 T4857 T4854 conj translation,frameshift
R3107 T4858 T4838 punct ", ",produced
R3108 T4859 T4860 det no,protein
R3109 T4860 T4838 nsubjpass protein,produced
R3110 T4861 T4860 amod functional,protein
R3111 T4862 T4860 nmod MTF,protein
R3112 T4863 T4862 punct -,MTF
R3113 T4864 T4862 nummod 1,MTF
R3114 T4865 T4838 aux can,produced
R3115 T4866 T4838 auxpass be,produced
R3116 T4867 T4838 punct .,produced

2_test

Id Subject Object Predicate Lexical cue
16221973-7660125-77403422 543-545 7660125 denotes 32
16221973-7660125-77403423 687-689 7660125 denotes 32

craft-ca-core-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T4508 43-47 NCBITaxon:10088 denotes mice
T4509 78-82 PR:000010717 denotes Mtf1
T4510 83-89 SO:0001023 denotes allele
T4511 90-94 PR:000010717 denotes Mtf1
T4512 94-98 SO:0000346 denotes loxP
T4513 105-110 SO:0000147 denotes exons
T4514 177-183 SO:0000417 denotes domain
T4515 189-196 SO:0000357 denotes flanked
T4516 200-210 SO:0000346 denotes loxP sites
T4517 224-228 NCBITaxon:10088 denotes Mice
T4518 248-252 PR:000010717 denotes Mtf1
T4519 252-256 SO:0000346 denotes loxP
T4520 257-263 SO:0001023 denotes allele
T4521 290-297 NCBITaxon:33208 denotes animals
T4522 337-339 PR:000010788 denotes Mx
T4523 364-373 GO:0010467 denotes expressed
T4524 397-404 GO:0065007 denotes control
T4525 412-417 NCBITaxon:10088 denotes mouse
T4526 418-421 PR:000010788 denotes Mx1
T4527 422-426 SO:0000704 denotes gene
T4528 427-435 SO:0000167 denotes promoter
T4529 477-493 PR:000024938 denotes interferon alpha
T4531 477-487,497-501 PR:000024939 denotes interferon beta
T4532 516-531 SO:0000985 denotes double-stranded
T4533 536-538 CHEBI:76777 denotes pI
T4534 605-610 UBERON:0002107 denotes liver
T4535 635-642 UBERON:0000479 denotes tissues
T4536 664-670 UBERON:0002106 denotes spleen
T4537 680-685 UBERON:0000955 denotes brain
T4538 723-728 SO:0000147 denotes exons
T4539 782-793 GO:0006412 denotes translation
T4540 814-819 PR:000010717 denotes MTF-1

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T4581 19-32 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T4582 43-47 NCBITaxon:10088 denotes mice
T4583 69-77 SO_EXT:sequence_alteration_process denotes modified
T4584 78-82 PR_EXT:000010717 denotes Mtf1
T4585 83-89 SO_EXT:0001023 denotes allele
T4586 90-94 PR_EXT:000010717 denotes Mtf1
T4587 94-98 SO_EXT:0000346 denotes loxP
T4588 105-110 SO_EXT:0000147 denotes exons
T4589 120-128 SO_EXT:sequence_coding_function denotes encoding
T4590 145-149 CHEBI_EXT:zinc denotes zinc
T4591 165-168 CHEBI_SO_EXT:DNA denotes DNA
T4592 169-176 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T4593 177-183 SO_EXT:0000417 denotes domain
T4594 189-196 SO:0000357 denotes flanked
T4595 200-210 SO_EXT:0000346 denotes loxP sites
T4596 224-228 NCBITaxon:10088 denotes Mice
T4597 248-252 PR_EXT:000010717 denotes Mtf1
T4598 252-256 SO_EXT:0000346 denotes loxP
T4599 257-263 SO_EXT:0001023 denotes allele
T4600 290-297 NCBITaxon:33208 denotes animals
T4601 309-320 GO_EXT:recombinase denotes recombinase
T4602 321-331 SO_EXT:transgenic_entity denotes transgenic
T4603 337-339 PR_EXT:000010788 denotes Mx
T4604 349-360 GO_EXT:recombinase denotes recombinase
T4605 364-373 GO:0010467 denotes expressed
T4606 397-404 GO:0065007 denotes control
T4607 412-417 NCBITaxon:10088 denotes mouse
T4608 418-421 PR_EXT:000010788 denotes Mx1
T4609 422-426 SO_EXT:0000704 denotes gene
T4610 427-435 SO_EXT:0000167 denotes promoter
T4611 477-493 PR_EXT:000024938 denotes interferon alpha
T4613 477-487,497-501 PR_EXT:000024939 denotes interferon beta
T4614 516-535 CHEBI_SO_EXT:double_stranded_RNA denotes double-stranded RNA
T4615 536-538 CHEBI:76777 denotes pI
T4616 539-541 CHEBI_EXT:polyC_acid denotes pC
T4617 561-569 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T4618 605-610 UBERON:0002107 denotes liver
T4619 635-642 UBERON:0000479 denotes tissues
T4620 664-670 UBERON:0002106 denotes spleen
T4621 680-685 UBERON:0000955 denotes brain
T4622 711-719 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T4623 723-728 SO_EXT:0000147 denotes exons
T4624 757-767 GO_SO_EXT:frameshift_entity_or_process denotes frameshift
T4625 782-798 GO_SO_EXT:translational_stop_entity_or_process denotes translation stop
T4626 814-819 PR_EXT:000010717 denotes MTF-1
T4627 820-827 CHEBI_PR_EXT:protein denotes protein