Id |
Subject |
Object |
Predicate |
Lexical cue |
T4679 |
0-10 |
NN |
denotes |
Generation |
T4680 |
11-13 |
IN |
denotes |
of |
T4681 |
14-16 |
DT |
denotes |
an |
T4682 |
63-67 |
NN |
denotes |
line |
T4683 |
17-26 |
JJ |
denotes |
inducible |
T4684 |
26-28 |
, |
denotes |
, |
T4685 |
28-33 |
NN |
denotes |
liver |
T4686 |
34-42 |
JJ |
denotes |
specific |
T4687 |
33-34 |
HYPH |
denotes |
- |
T4688 |
43-47 |
NN |
denotes |
Mtf1 |
T4689 |
48-56 |
NN |
denotes |
knockout |
T4690 |
57-62 |
NN |
denotes |
mouse |
T4691 |
67-291 |
sentence |
denotes |
Using a homologous recombination strategy, mice were obtained with a modified Mtf1 allele Mtf1loxP where exons 3 and 4, encoding four of the six zinc fingers of the DNA-binding domain, are flanked by loxP sites (Figure 1a). |
T4692 |
68-73 |
VBG |
denotes |
Using |
T4693 |
121-129 |
VBN |
denotes |
obtained |
T4694 |
74-75 |
DT |
denotes |
a |
T4695 |
101-109 |
NN |
denotes |
strategy |
T4696 |
76-86 |
JJ |
denotes |
homologous |
T4697 |
87-100 |
NN |
denotes |
recombination |
T4698 |
109-111 |
, |
denotes |
, |
T4699 |
111-115 |
NNS |
denotes |
mice |
T4700 |
116-120 |
VBD |
denotes |
were |
T4701 |
130-134 |
IN |
denotes |
with |
T4702 |
135-136 |
DT |
denotes |
a |
T4703 |
158-166 |
NN |
denotes |
Mtf1loxP |
T4704 |
137-145 |
VBN |
denotes |
modified |
T4705 |
146-150 |
NN |
denotes |
Mtf1 |
T4706 |
151-157 |
NN |
denotes |
allele |
T4707 |
167-172 |
WRB |
denotes |
where |
T4708 |
257-264 |
VBN |
denotes |
flanked |
T4709 |
173-178 |
NNS |
denotes |
exons |
T4710 |
179-180 |
CD |
denotes |
3 |
T4711 |
181-184 |
CC |
denotes |
and |
T4712 |
185-186 |
CD |
denotes |
4 |
T4713 |
186-188 |
, |
denotes |
, |
T4714 |
188-196 |
VBG |
denotes |
encoding |
T4715 |
197-201 |
CD |
denotes |
four |
T4716 |
202-204 |
IN |
denotes |
of |
T4717 |
205-208 |
DT |
denotes |
the |
T4718 |
218-225 |
NNS |
denotes |
fingers |
T4719 |
209-212 |
CD |
denotes |
six |
T4720 |
213-217 |
NN |
denotes |
zinc |
T4721 |
226-228 |
IN |
denotes |
of |
T4722 |
229-232 |
DT |
denotes |
the |
T4723 |
245-251 |
NN |
denotes |
domain |
T4724 |
233-236 |
NN |
denotes |
DNA |
T4725 |
237-244 |
VBG |
denotes |
binding |
T4726 |
236-237 |
HYPH |
denotes |
- |
T4727 |
251-253 |
, |
denotes |
, |
T4728 |
253-256 |
VBP |
denotes |
are |
T4729 |
265-267 |
IN |
denotes |
by |
T4730 |
268-272 |
NN |
denotes |
loxP |
T4731 |
273-278 |
NNS |
denotes |
sites |
T4732 |
279-280 |
-LRB- |
denotes |
( |
T4733 |
287-289 |
NN |
denotes |
1a |
T4734 |
280-286 |
NN |
denotes |
Figure |
T4735 |
289-290 |
-RRB- |
denotes |
) |
T4736 |
290-291 |
. |
denotes |
. |
T4737 |
291-412 |
sentence |
denotes |
Mice homozygous for the Mtf1loxP allele were further crossed with animals of the Cre recombinase transgenic line Mx-cre. |
T4738 |
292-296 |
NNS |
denotes |
Mice |
T4739 |
345-352 |
VBN |
denotes |
crossed |
T4740 |
297-307 |
JJ |
denotes |
homozygous |
T4741 |
308-311 |
IN |
denotes |
for |
T4742 |
312-315 |
DT |
denotes |
the |
T4743 |
325-331 |
NN |
denotes |
allele |
T4744 |
316-324 |
NN |
denotes |
Mtf1loxP |
T4745 |
332-336 |
VBD |
denotes |
were |
T4746 |
337-344 |
RB |
denotes |
further |
T4747 |
353-357 |
IN |
denotes |
with |
T4748 |
358-365 |
NNS |
denotes |
animals |
T4749 |
366-368 |
IN |
denotes |
of |
T4750 |
369-372 |
DT |
denotes |
the |
T4751 |
400-404 |
NN |
denotes |
line |
T4752 |
373-376 |
NN |
denotes |
Cre |
T4753 |
377-388 |
NN |
denotes |
recombinase |
T4754 |
389-399 |
JJ |
denotes |
transgenic |
T4755 |
405-407 |
NN |
denotes |
Mx |
T4756 |
408-411 |
NN |
denotes |
cre |
T4757 |
407-408 |
HYPH |
denotes |
- |
T4758 |
411-412 |
. |
denotes |
. |
T4759 |
412-615 |
sentence |
denotes |
Cre recombinase is expressed in this line under the control of the mouse Mx1 gene promoter, which is inducible by administration of interferon alpha or beta, or synthetic double-stranded RNA pI–pC (32). |
T4760 |
413-416 |
NN |
denotes |
Cre |
T4761 |
417-428 |
NN |
denotes |
recombinase |
T4762 |
432-441 |
VBN |
denotes |
expressed |
T4763 |
429-431 |
VBZ |
denotes |
is |
T4764 |
442-444 |
IN |
denotes |
in |
T4765 |
445-449 |
DT |
denotes |
this |
T4766 |
450-454 |
NN |
denotes |
line |
T4767 |
455-460 |
IN |
denotes |
under |
T4768 |
461-464 |
DT |
denotes |
the |
T4769 |
465-472 |
NN |
denotes |
control |
T4770 |
473-475 |
IN |
denotes |
of |
T4771 |
476-479 |
DT |
denotes |
the |
T4772 |
495-503 |
NN |
denotes |
promoter |
T4773 |
480-485 |
NN |
denotes |
mouse |
T4774 |
486-489 |
NN |
denotes |
Mx1 |
T4775 |
490-494 |
NN |
denotes |
gene |
T4776 |
503-505 |
, |
denotes |
, |
T4777 |
505-510 |
WDT |
denotes |
which |
T4778 |
511-513 |
VBZ |
denotes |
is |
T4779 |
514-523 |
JJ |
denotes |
inducible |
T4780 |
524-526 |
IN |
denotes |
by |
T4781 |
527-541 |
NN |
denotes |
administration |
T4782 |
542-544 |
IN |
denotes |
of |
T4783 |
545-555 |
NN |
denotes |
interferon |
T4784 |
556-561 |
NN |
denotes |
alpha |
T4785 |
562-564 |
CC |
denotes |
or |
T4786 |
565-569 |
NN |
denotes |
beta |
T4787 |
569-571 |
, |
denotes |
, |
T4788 |
571-573 |
CC |
denotes |
or |
T4789 |
574-583 |
JJ |
denotes |
synthetic |
T4790 |
607-609 |
NN |
denotes |
pC |
T4791 |
584-590 |
JJ |
denotes |
double |
T4792 |
591-599 |
VBN |
denotes |
stranded |
T4793 |
590-591 |
HYPH |
denotes |
- |
T4794 |
600-603 |
NN |
denotes |
RNA |
T4795 |
604-606 |
NN |
denotes |
pI |
T4796 |
606-607 |
HYPH |
denotes |
– |
T4797 |
610-611 |
-LRB- |
denotes |
( |
T4798 |
611-613 |
CD |
denotes |
32 |
T4799 |
613-614 |
-RRB- |
denotes |
) |
T4800 |
614-615 |
. |
denotes |
. |
T4801 |
615-759 |
sentence |
denotes |
Cre-mediated deletion was reported to be complete in the liver, while varying in other tissues, ranging from 94% in spleen to 8% in brain (32). |
T4802 |
616-619 |
NN |
denotes |
Cre |
T4803 |
620-628 |
VBN |
denotes |
mediated |
T4804 |
619-620 |
HYPH |
denotes |
- |
T4805 |
629-637 |
NN |
denotes |
deletion |
T4806 |
642-650 |
VBN |
denotes |
reported |
T4807 |
638-641 |
VBD |
denotes |
was |
T4808 |
651-653 |
TO |
denotes |
to |
T4809 |
654-656 |
VB |
denotes |
be |
T4810 |
657-665 |
JJ |
denotes |
complete |
T4811 |
666-668 |
IN |
denotes |
in |
T4812 |
669-672 |
DT |
denotes |
the |
T4813 |
673-678 |
NN |
denotes |
liver |
T4814 |
678-680 |
, |
denotes |
, |
T4815 |
680-685 |
IN |
denotes |
while |
T4816 |
686-693 |
VBG |
denotes |
varying |
T4817 |
694-696 |
IN |
denotes |
in |
T4818 |
697-702 |
JJ |
denotes |
other |
T4819 |
703-710 |
NNS |
denotes |
tissues |
T4820 |
710-712 |
, |
denotes |
, |
T4821 |
712-719 |
VBG |
denotes |
ranging |
T4822 |
720-724 |
IN |
denotes |
from |
T4823 |
725-727 |
CD |
denotes |
94 |
T4824 |
727-728 |
NN |
denotes |
% |
T4825 |
729-731 |
IN |
denotes |
in |
T4826 |
732-738 |
NN |
denotes |
spleen |
T4827 |
739-741 |
IN |
denotes |
to |
T4828 |
742-743 |
CD |
denotes |
8 |
T4829 |
743-744 |
NN |
denotes |
% |
T4830 |
745-747 |
IN |
denotes |
in |
T4831 |
748-753 |
NN |
denotes |
brain |
T4832 |
754-755 |
-LRB- |
denotes |
( |
T4833 |
755-757 |
CD |
denotes |
32 |
T4834 |
757-758 |
-RRB- |
denotes |
) |
T4835 |
758-759 |
. |
denotes |
. |
T4836 |
759-912 |
sentence |
denotes |
After Cre-mediated deletion of exons 3 and 4, which results in a frameshift and premature translation stop, no functional MTF-1 protein can be produced. |
T4837 |
760-765 |
IN |
denotes |
After |
T4838 |
903-911 |
VBN |
denotes |
produced |
T4839 |
766-769 |
NN |
denotes |
Cre |
T4840 |
770-778 |
VBN |
denotes |
mediated |
T4841 |
769-770 |
HYPH |
denotes |
- |
T4842 |
779-787 |
NN |
denotes |
deletion |
T4843 |
788-790 |
IN |
denotes |
of |
T4844 |
791-796 |
NNS |
denotes |
exons |
T4845 |
797-798 |
CD |
denotes |
3 |
T4846 |
799-802 |
CC |
denotes |
and |
T4847 |
803-804 |
CD |
denotes |
4 |
T4848 |
804-806 |
, |
denotes |
, |
T4849 |
806-811 |
WDT |
denotes |
which |
T4850 |
812-819 |
VBZ |
denotes |
results |
T4851 |
820-822 |
IN |
denotes |
in |
T4852 |
823-824 |
DT |
denotes |
a |
T4853 |
862-866 |
NN |
denotes |
stop |
T4854 |
825-835 |
NN |
denotes |
frameshift |
T4855 |
836-839 |
CC |
denotes |
and |
T4856 |
840-849 |
JJ |
denotes |
premature |
T4857 |
850-861 |
NN |
denotes |
translation |
T4858 |
866-868 |
, |
denotes |
, |
T4859 |
868-870 |
DT |
denotes |
no |
T4860 |
888-895 |
NN |
denotes |
protein |
T4861 |
871-881 |
JJ |
denotes |
functional |
T4862 |
882-885 |
NN |
denotes |
MTF |
T4863 |
885-886 |
HYPH |
denotes |
- |
T4864 |
886-887 |
CD |
denotes |
1 |
T4865 |
896-899 |
MD |
denotes |
can |
T4866 |
900-902 |
VB |
denotes |
be |
T4867 |
911-912 |
. |
denotes |
. |
T4868 |
912-1184 |
sentence |
denotes |
For induction of Cre recombinase, Mtf1 conditional knockout mice harboring the Mx-cre transgene (Mtf1Mx-cre) received four intraperitoneal pI–pC injections at 3 day intervals (pI–pC induction); control littermates without transgene (Mtf1loxP) received similar injections. |
T4869 |
913-916 |
IN |
denotes |
For |
T4870 |
1022-1030 |
VBD |
denotes |
received |
T4871 |
917-926 |
NN |
denotes |
induction |
T4872 |
927-929 |
IN |
denotes |
of |
T4873 |
930-933 |
NN |
denotes |
Cre |
T4874 |
934-945 |
NN |
denotes |
recombinase |
T4875 |
945-947 |
, |
denotes |
, |
T4876 |
947-951 |
NN |
denotes |
Mtf1 |
T4877 |
973-977 |
NNS |
denotes |
mice |
T4878 |
952-963 |
JJ |
denotes |
conditional |
T4879 |
964-972 |
NN |
denotes |
knockout |
T4880 |
978-987 |
VBG |
denotes |
harboring |
T4881 |
988-991 |
DT |
denotes |
the |
T4882 |
999-1008 |
NN |
denotes |
transgene |
T4883 |
992-994 |
NN |
denotes |
Mx |
T4884 |
995-998 |
NN |
denotes |
cre |
T4885 |
994-995 |
HYPH |
denotes |
- |
T4886 |
1009-1010 |
-LRB- |
denotes |
( |
T4887 |
1010-1016 |
NN |
denotes |
Mtf1Mx |
T4888 |
1017-1020 |
NN |
denotes |
cre |
T4889 |
1016-1017 |
HYPH |
denotes |
- |
T4890 |
1020-1021 |
-RRB- |
denotes |
) |
T4891 |
1156-1164 |
VBD |
denotes |
received |
T4892 |
1031-1035 |
CD |
denotes |
four |
T4893 |
1058-1068 |
NNS |
denotes |
injections |
T4894 |
1036-1051 |
JJ |
denotes |
intraperitoneal |
T4895 |
1052-1054 |
NN |
denotes |
pI |
T4896 |
1055-1057 |
NN |
denotes |
pC |
T4897 |
1054-1055 |
HYPH |
denotes |
– |
T4898 |
1069-1071 |
IN |
denotes |
at |
T4899 |
1072-1073 |
CD |
denotes |
3 |
T4900 |
1074-1077 |
NN |
denotes |
day |
T4901 |
1078-1087 |
NNS |
denotes |
intervals |
T4902 |
1088-1089 |
-LRB- |
denotes |
( |
T4903 |
1095-1104 |
NN |
denotes |
induction |
T4904 |
1089-1091 |
NN |
denotes |
pI |
T4905 |
1092-1094 |
NN |
denotes |
pC |
T4906 |
1091-1092 |
HYPH |
denotes |
– |
T4907 |
1104-1105 |
-RRB- |
denotes |
) |
T4908 |
1105-1106 |
: |
denotes |
; |
T4909 |
1107-1114 |
NN |
denotes |
control |
T4910 |
1115-1126 |
NNS |
denotes |
littermates |
T4911 |
1127-1134 |
IN |
denotes |
without |
T4912 |
1135-1144 |
NN |
denotes |
transgene |
T4913 |
1145-1146 |
-LRB- |
denotes |
( |
T4914 |
1146-1154 |
NN |
denotes |
Mtf1loxP |
T4915 |
1154-1155 |
-RRB- |
denotes |
) |
T4916 |
1165-1172 |
JJ |
denotes |
similar |
T4917 |
1173-1183 |
NNS |
denotes |
injections |
T4918 |
1183-1184 |
. |
denotes |
. |
T4919 |
1184-1353 |
sentence |
denotes |
Using RT–PCRs (Figure 1b), a shortened product was obtained with RNA from Mtf1Mx-cre livers, indicating a successful excision of exons 3 and 4 of Mtf1 in these animals. |
T4920 |
1185-1190 |
VBG |
denotes |
Using |
T4921 |
1236-1244 |
VBN |
denotes |
obtained |
T4922 |
1191-1193 |
NN |
denotes |
RT |
T4923 |
1194-1198 |
NNS |
denotes |
PCRs |
T4924 |
1193-1194 |
HYPH |
denotes |
– |
T4925 |
1199-1200 |
-LRB- |
denotes |
( |
T4926 |
1207-1209 |
NN |
denotes |
1b |
T4927 |
1200-1206 |
NN |
denotes |
Figure |
T4928 |
1209-1210 |
-RRB- |
denotes |
) |
T4929 |
1210-1212 |
, |
denotes |
, |
T4930 |
1212-1213 |
DT |
denotes |
a |
T4931 |
1224-1231 |
NN |
denotes |
product |
T4932 |
1214-1223 |
VBN |
denotes |
shortened |
T4933 |
1232-1235 |
VBD |
denotes |
was |
T4934 |
1245-1249 |
IN |
denotes |
with |
T4935 |
1250-1253 |
NN |
denotes |
RNA |
T4936 |
1254-1258 |
IN |
denotes |
from |
T4937 |
1259-1265 |
NN |
denotes |
Mtf1Mx |
T4938 |
1266-1269 |
NN |
denotes |
cre |
T4939 |
1265-1266 |
HYPH |
denotes |
- |
T4940 |
1270-1276 |
NNS |
denotes |
livers |
T4941 |
1276-1278 |
, |
denotes |
, |
T4942 |
1278-1288 |
VBG |
denotes |
indicating |
T4943 |
1289-1290 |
DT |
denotes |
a |
T4944 |
1302-1310 |
NN |
denotes |
excision |
T4945 |
1291-1301 |
JJ |
denotes |
successful |
T4946 |
1311-1313 |
IN |
denotes |
of |
T4947 |
1314-1319 |
NNS |
denotes |
exons |
T4948 |
1320-1321 |
CD |
denotes |
3 |
T4949 |
1322-1325 |
CC |
denotes |
and |
T4950 |
1326-1327 |
CD |
denotes |
4 |
T4951 |
1328-1330 |
IN |
denotes |
of |
T4952 |
1331-1335 |
NN |
denotes |
Mtf1 |
T4953 |
1336-1338 |
IN |
denotes |
in |
T4954 |
1339-1344 |
DT |
denotes |
these |
T4955 |
1345-1352 |
NNS |
denotes |
animals |
T4956 |
1352-1353 |
. |
denotes |
. |
T4957 |
1353-1528 |
sentence |
denotes |
On close examination, a very faint band similar in size to full-length signal was also observed in those mice, probably due to a low amount of residual full-length Mtf1 mRNA. |
T4958 |
1354-1356 |
IN |
denotes |
On |
T4959 |
1441-1449 |
VBN |
denotes |
observed |
T4960 |
1357-1362 |
JJ |
denotes |
close |
T4961 |
1363-1374 |
NN |
denotes |
examination |
T4962 |
1374-1376 |
, |
denotes |
, |
T4963 |
1376-1377 |
DT |
denotes |
a |
T4964 |
1389-1393 |
NN |
denotes |
band |
T4965 |
1378-1382 |
RB |
denotes |
very |
T4966 |
1383-1388 |
JJ |
denotes |
faint |
T4967 |
1394-1401 |
JJ |
denotes |
similar |
T4968 |
1402-1404 |
IN |
denotes |
in |
T4969 |
1405-1409 |
NN |
denotes |
size |
T4970 |
1410-1412 |
IN |
denotes |
to |
T4971 |
1413-1417 |
JJ |
denotes |
full |
T4972 |
1418-1424 |
NN |
denotes |
length |
T4973 |
1417-1418 |
HYPH |
denotes |
- |
T4974 |
1425-1431 |
NN |
denotes |
signal |
T4975 |
1432-1435 |
VBD |
denotes |
was |
T4976 |
1436-1440 |
RB |
denotes |
also |
T4977 |
1450-1452 |
IN |
denotes |
in |
T4978 |
1453-1458 |
DT |
denotes |
those |
T4979 |
1459-1463 |
NNS |
denotes |
mice |
T4980 |
1463-1465 |
, |
denotes |
, |
T4981 |
1465-1473 |
RB |
denotes |
probably |
T4982 |
1474-1477 |
IN |
denotes |
due |
T4983 |
1478-1480 |
IN |
denotes |
to |
T4984 |
1481-1482 |
DT |
denotes |
a |
T4985 |
1487-1493 |
NN |
denotes |
amount |
T4986 |
1483-1486 |
JJ |
denotes |
low |
T4987 |
1494-1496 |
IN |
denotes |
of |
T4988 |
1497-1505 |
JJ |
denotes |
residual |
T4989 |
1523-1527 |
NN |
denotes |
mRNA |
T4990 |
1506-1510 |
JJ |
denotes |
full |
T4991 |
1511-1517 |
NN |
denotes |
length |
T4992 |
1510-1511 |
HYPH |
denotes |
- |
T4993 |
1518-1522 |
NN |
denotes |
Mtf1 |
T4994 |
1527-1528 |
. |
denotes |
. |
T4995 |
1528-1778 |
sentence |
denotes |
The level of functional MTF-1 protein was examined by EMSA (Figure 1c): MTF-1 protein–DNA complex was detectable with liver protein extract from an Mtf1loxP control mouse, but no functional MRE-binding protein was observed with an Mtf1Mx-cre sample. |
T4996 |
1529-1532 |
DT |
denotes |
The |
T4997 |
1533-1538 |
NN |
denotes |
level |
T4998 |
1571-1579 |
VBN |
denotes |
examined |
T4999 |
1539-1541 |
IN |
denotes |
of |
T5000 |
1542-1552 |
JJ |
denotes |
functional |
T5001 |
1559-1566 |
NN |
denotes |
protein |
T5002 |
1553-1556 |
NN |
denotes |
MTF |
T5003 |
1556-1557 |
HYPH |
denotes |
- |
T5004 |
1557-1558 |
CD |
denotes |
1 |
T5005 |
1567-1570 |
VBD |
denotes |
was |
T5006 |
1627-1630 |
VBD |
denotes |
was |
T5007 |
1580-1582 |
IN |
denotes |
by |
T5008 |
1583-1587 |
NN |
denotes |
EMSA |
T5009 |
1588-1589 |
-LRB- |
denotes |
( |
T5010 |
1596-1598 |
NN |
denotes |
1c |
T5011 |
1589-1595 |
NN |
denotes |
Figure |
T5012 |
1598-1599 |
-RRB- |
denotes |
) |
T5013 |
1599-1601 |
: |
denotes |
: |
T5014 |
1601-1604 |
NN |
denotes |
MTF |
T5015 |
1619-1626 |
NN |
denotes |
complex |
T5016 |
1604-1605 |
HYPH |
denotes |
- |
T5017 |
1605-1606 |
CD |
denotes |
1 |
T5018 |
1607-1614 |
NN |
denotes |
protein |
T5019 |
1614-1615 |
HYPH |
denotes |
– |
T5020 |
1615-1618 |
NN |
denotes |
DNA |
T5021 |
1631-1641 |
JJ |
denotes |
detectable |
T5022 |
1642-1646 |
IN |
denotes |
with |
T5023 |
1647-1652 |
NN |
denotes |
liver |
T5024 |
1661-1668 |
NN |
denotes |
extract |
T5025 |
1653-1660 |
NN |
denotes |
protein |
T5026 |
1669-1673 |
IN |
denotes |
from |
T5027 |
1674-1676 |
DT |
denotes |
an |
T5028 |
1694-1699 |
NN |
denotes |
mouse |
T5029 |
1677-1685 |
NN |
denotes |
Mtf1loxP |
T5030 |
1686-1693 |
NN |
denotes |
control |
T5031 |
1699-1701 |
, |
denotes |
, |
T5032 |
1701-1704 |
CC |
denotes |
but |
T5033 |
1705-1707 |
DT |
denotes |
no |
T5034 |
1731-1738 |
NN |
denotes |
protein |
T5035 |
1708-1718 |
JJ |
denotes |
functional |
T5036 |
1719-1722 |
NN |
denotes |
MRE |
T5037 |
1723-1730 |
VBG |
denotes |
binding |
T5038 |
1722-1723 |
HYPH |
denotes |
- |
T5039 |
1743-1751 |
VBN |
denotes |
observed |
T5040 |
1739-1742 |
VBD |
denotes |
was |
T5041 |
1752-1756 |
IN |
denotes |
with |
T5042 |
1757-1759 |
DT |
denotes |
an |
T5043 |
1771-1777 |
NN |
denotes |
sample |
T5044 |
1760-1766 |
NN |
denotes |
Mtf1Mx |
T5045 |
1767-1770 |
NN |
denotes |
cre |
T5046 |
1766-1767 |
HYPH |
denotes |
- |
T5047 |
1777-1778 |
. |
denotes |
. |
T5048 |
1778-1874 |
sentence |
denotes |
Thus, deletion of exons 3 and 4 of Mtf1 in the liver of Mtf1Mx-cre mice was virtually complete. |
T5049 |
1779-1783 |
RB |
denotes |
Thus |
T5050 |
1851-1854 |
VBD |
denotes |
was |
T5051 |
1783-1785 |
, |
denotes |
, |
T5052 |
1785-1793 |
NN |
denotes |
deletion |
T5053 |
1794-1796 |
IN |
denotes |
of |
T5054 |
1797-1802 |
NNS |
denotes |
exons |
T5055 |
1803-1804 |
CD |
denotes |
3 |
T5056 |
1805-1808 |
CC |
denotes |
and |
T5057 |
1809-1810 |
CD |
denotes |
4 |
T5058 |
1811-1813 |
IN |
denotes |
of |
T5059 |
1814-1818 |
NN |
denotes |
Mtf1 |
T5060 |
1819-1821 |
IN |
denotes |
in |
T5061 |
1822-1825 |
DT |
denotes |
the |
T5062 |
1826-1831 |
NN |
denotes |
liver |
T5063 |
1832-1834 |
IN |
denotes |
of |
T5064 |
1835-1841 |
NN |
denotes |
Mtf1Mx |
T5065 |
1842-1845 |
NN |
denotes |
cre |
T5066 |
1841-1842 |
HYPH |
denotes |
- |
T5067 |
1846-1850 |
NNS |
denotes |
mice |
T5068 |
1855-1864 |
RB |
denotes |
virtually |
T5069 |
1865-1873 |
JJ |
denotes |
complete |
T5070 |
1873-1874 |
. |
denotes |
. |
T5071 |
1874-1977 |
sentence |
denotes |
All examined liver-specific knockout mice were viable under laboratory conditions and appeared normal. |
T5072 |
1875-1878 |
DT |
denotes |
All |
T5073 |
1912-1916 |
NNS |
denotes |
mice |
T5074 |
1879-1887 |
VBN |
denotes |
examined |
T5075 |
1888-1893 |
NN |
denotes |
liver |
T5076 |
1894-1902 |
JJ |
denotes |
specific |
T5077 |
1893-1894 |
HYPH |
denotes |
- |
T5078 |
1903-1911 |
NN |
denotes |
knockout |
T5079 |
1917-1921 |
VBD |
denotes |
were |
T5080 |
1922-1928 |
JJ |
denotes |
viable |
T5081 |
1929-1934 |
IN |
denotes |
under |
T5082 |
1935-1945 |
NN |
denotes |
laboratory |
T5083 |
1946-1956 |
NNS |
denotes |
conditions |
T5084 |
1957-1960 |
CC |
denotes |
and |
T5085 |
1961-1969 |
VBD |
denotes |
appeared |
T5086 |
1970-1976 |
JJ |
denotes |
normal |
T5087 |
1976-1977 |
. |
denotes |
. |
R2939 |
T4680 |
T4679 |
prep |
of,Generation |
R2940 |
T4681 |
T4682 |
det |
an,line |
R2941 |
T4682 |
T4680 |
pobj |
line,of |
R2942 |
T4683 |
T4682 |
amod |
inducible,line |
R2943 |
T4684 |
T4682 |
punct |
", ",line |
R2944 |
T4685 |
T4686 |
npadvmod |
liver,specific |
R2945 |
T4686 |
T4682 |
amod |
specific,line |
R2946 |
T4687 |
T4686 |
punct |
-,specific |
R2947 |
T4688 |
T4689 |
compound |
Mtf1,knockout |
R2948 |
T4689 |
T4682 |
compound |
knockout,line |
R2949 |
T4690 |
T4682 |
compound |
mouse,line |
R2950 |
T4692 |
T4693 |
advcl |
Using,obtained |
R2951 |
T4694 |
T4695 |
det |
a,strategy |
R2952 |
T4695 |
T4692 |
dobj |
strategy,Using |
R2953 |
T4696 |
T4695 |
amod |
homologous,strategy |
R2954 |
T4697 |
T4695 |
compound |
recombination,strategy |
R2955 |
T4698 |
T4693 |
punct |
", ",obtained |
R2956 |
T4699 |
T4693 |
nsubjpass |
mice,obtained |
R2957 |
T4700 |
T4693 |
auxpass |
were,obtained |
R2958 |
T4701 |
T4693 |
prep |
with,obtained |
R2959 |
T4702 |
T4703 |
det |
a,Mtf1loxP |
R2960 |
T4703 |
T4701 |
pobj |
Mtf1loxP,with |
R2961 |
T4704 |
T4703 |
amod |
modified,Mtf1loxP |
R2962 |
T4705 |
T4703 |
compound |
Mtf1,Mtf1loxP |
R2963 |
T4706 |
T4703 |
compound |
allele,Mtf1loxP |
R2964 |
T4707 |
T4708 |
advmod |
where,flanked |
R2965 |
T4708 |
T4693 |
advcl |
flanked,obtained |
R2966 |
T4709 |
T4710 |
nmod |
exons,3 |
R2967 |
T4710 |
T4708 |
nsubjpass |
3,flanked |
R2968 |
T4711 |
T4710 |
cc |
and,3 |
R2969 |
T4712 |
T4710 |
conj |
4,3 |
R2970 |
T4713 |
T4710 |
punct |
", ",3 |
R2971 |
T4714 |
T4710 |
acl |
encoding,3 |
R2972 |
T4715 |
T4714 |
dobj |
four,encoding |
R2973 |
T4716 |
T4715 |
prep |
of,four |
R2974 |
T4717 |
T4718 |
det |
the,fingers |
R2975 |
T4718 |
T4716 |
pobj |
fingers,of |
R2976 |
T4719 |
T4718 |
nummod |
six,fingers |
R2977 |
T4720 |
T4718 |
compound |
zinc,fingers |
R2978 |
T4721 |
T4718 |
prep |
of,fingers |
R2979 |
T4722 |
T4723 |
det |
the,domain |
R2980 |
T4723 |
T4721 |
pobj |
domain,of |
R2981 |
T4724 |
T4725 |
npadvmod |
DNA,binding |
R2982 |
T4725 |
T4723 |
amod |
binding,domain |
R2983 |
T4726 |
T4725 |
punct |
-,binding |
R2984 |
T4727 |
T4708 |
punct |
", ",flanked |
R2985 |
T4728 |
T4708 |
auxpass |
are,flanked |
R2986 |
T4729 |
T4708 |
agent |
by,flanked |
R2987 |
T4730 |
T4731 |
compound |
loxP,sites |
R2988 |
T4731 |
T4729 |
pobj |
sites,by |
R2989 |
T4732 |
T4733 |
punct |
(,1a |
R2990 |
T4733 |
T4708 |
parataxis |
1a,flanked |
R2991 |
T4734 |
T4733 |
compound |
Figure,1a |
R2992 |
T4735 |
T4733 |
punct |
),1a |
R2993 |
T4736 |
T4693 |
punct |
.,obtained |
R2994 |
T4738 |
T4739 |
nsubjpass |
Mice,crossed |
R2995 |
T4740 |
T4738 |
amod |
homozygous,Mice |
R2996 |
T4741 |
T4740 |
prep |
for,homozygous |
R2997 |
T4742 |
T4743 |
det |
the,allele |
R2998 |
T4743 |
T4741 |
pobj |
allele,for |
R2999 |
T4744 |
T4743 |
compound |
Mtf1loxP,allele |
R3000 |
T4745 |
T4739 |
auxpass |
were,crossed |
R3001 |
T4746 |
T4739 |
advmod |
further,crossed |
R3002 |
T4747 |
T4739 |
prep |
with,crossed |
R3003 |
T4748 |
T4747 |
pobj |
animals,with |
R3004 |
T4749 |
T4748 |
prep |
of,animals |
R3005 |
T4750 |
T4751 |
det |
the,line |
R3006 |
T4751 |
T4749 |
pobj |
line,of |
R3007 |
T4752 |
T4753 |
nmod |
Cre,recombinase |
R3008 |
T4753 |
T4751 |
nmod |
recombinase,line |
R3009 |
T4754 |
T4751 |
amod |
transgenic,line |
R3010 |
T4755 |
T4756 |
compound |
Mx,cre |
R3011 |
T4756 |
T4751 |
appos |
cre,line |
R3012 |
T4757 |
T4756 |
punct |
-,cre |
R3013 |
T4758 |
T4739 |
punct |
.,crossed |
R3014 |
T4760 |
T4761 |
compound |
Cre,recombinase |
R3015 |
T4761 |
T4762 |
nsubjpass |
recombinase,expressed |
R3016 |
T4763 |
T4762 |
auxpass |
is,expressed |
R3017 |
T4764 |
T4762 |
prep |
in,expressed |
R3018 |
T4765 |
T4766 |
det |
this,line |
R3019 |
T4766 |
T4764 |
pobj |
line,in |
R3020 |
T4767 |
T4762 |
prep |
under,expressed |
R3021 |
T4768 |
T4769 |
det |
the,control |
R3022 |
T4769 |
T4767 |
pobj |
control,under |
R3023 |
T4770 |
T4769 |
prep |
of,control |
R3024 |
T4771 |
T4772 |
det |
the,promoter |
R3025 |
T4772 |
T4770 |
pobj |
promoter,of |
R3026 |
T4773 |
T4772 |
compound |
mouse,promoter |
R3027 |
T4774 |
T4772 |
compound |
Mx1,promoter |
R3028 |
T4775 |
T4772 |
compound |
gene,promoter |
R3029 |
T4776 |
T4772 |
punct |
", ",promoter |
R3030 |
T4777 |
T4778 |
dep |
which,is |
R3031 |
T4778 |
T4772 |
relcl |
is,promoter |
R3032 |
T4779 |
T4778 |
acomp |
inducible,is |
R3033 |
T4780 |
T4779 |
prep |
by,inducible |
R3034 |
T4781 |
T4780 |
pobj |
administration,by |
R3035 |
T4782 |
T4781 |
prep |
of,administration |
R3036 |
T4783 |
T4784 |
compound |
interferon,alpha |
R3037 |
T4784 |
T4782 |
pobj |
alpha,of |
R3038 |
T4785 |
T4784 |
cc |
or,alpha |
R3039 |
T4786 |
T4784 |
conj |
beta,alpha |
R3040 |
T4787 |
T4784 |
punct |
", ",alpha |
R3041 |
T4788 |
T4784 |
cc |
or,alpha |
R3042 |
T4789 |
T4790 |
amod |
synthetic,pC |
R3043 |
T4790 |
T4784 |
conj |
pC,alpha |
R3044 |
T4791 |
T4792 |
amod |
double,stranded |
R3045 |
T4792 |
T4790 |
amod |
stranded,pC |
R3046 |
T4793 |
T4792 |
punct |
-,stranded |
R3047 |
T4794 |
T4790 |
compound |
RNA,pC |
R3048 |
T4795 |
T4790 |
compound |
pI,pC |
R3049 |
T4796 |
T4790 |
punct |
–,pC |
R3050 |
T4797 |
T4798 |
punct |
(,32 |
R3051 |
T4798 |
T4778 |
parataxis |
32,is |
R3052 |
T4799 |
T4798 |
punct |
),32 |
R3053 |
T4800 |
T4762 |
punct |
.,expressed |
R3054 |
T4802 |
T4803 |
npadvmod |
Cre,mediated |
R3055 |
T4803 |
T4805 |
amod |
mediated,deletion |
R3056 |
T4804 |
T4803 |
punct |
-,mediated |
R3057 |
T4805 |
T4806 |
nsubjpass |
deletion,reported |
R3058 |
T4807 |
T4806 |
auxpass |
was,reported |
R3059 |
T4808 |
T4809 |
aux |
to,be |
R3060 |
T4809 |
T4806 |
xcomp |
be,reported |
R3061 |
T4810 |
T4809 |
acomp |
complete,be |
R3062 |
T4811 |
T4809 |
prep |
in,be |
R3063 |
T4812 |
T4813 |
det |
the,liver |
R3064 |
T4813 |
T4811 |
pobj |
liver,in |
R3065 |
T4814 |
T4809 |
punct |
", ",be |
R3066 |
T4815 |
T4816 |
mark |
while,varying |
R3067 |
T4816 |
T4809 |
advcl |
varying,be |
R3068 |
T4817 |
T4816 |
prep |
in,varying |
R3069 |
T4818 |
T4819 |
amod |
other,tissues |
R3070 |
T4819 |
T4817 |
pobj |
tissues,in |
R3071 |
T4820 |
T4816 |
punct |
", ",varying |
R3072 |
T4821 |
T4816 |
advcl |
ranging,varying |
R3073 |
T4822 |
T4821 |
prep |
from,ranging |
R3074 |
T4823 |
T4824 |
nummod |
94,% |
R3075 |
T4824 |
T4822 |
pobj |
%,from |
R3076 |
T4825 |
T4824 |
prep |
in,% |
R3077 |
T4826 |
T4825 |
pobj |
spleen,in |
R3078 |
T4827 |
T4822 |
prep |
to,from |
R3079 |
T4828 |
T4829 |
nummod |
8,% |
R3080 |
T4829 |
T4827 |
pobj |
%,to |
R3081 |
T4830 |
T4829 |
prep |
in,% |
R3082 |
T4831 |
T4830 |
pobj |
brain,in |
R3083 |
T4832 |
T4833 |
punct |
(,32 |
R3084 |
T4833 |
T4816 |
parataxis |
32,varying |
R3085 |
T4834 |
T4833 |
punct |
),32 |
R3086 |
T4835 |
T4806 |
punct |
.,reported |
R3087 |
T4837 |
T4838 |
prep |
After,produced |
R3088 |
T4839 |
T4840 |
npadvmod |
Cre,mediated |
R3089 |
T4840 |
T4842 |
amod |
mediated,deletion |
R3090 |
T4841 |
T4840 |
punct |
-,mediated |
R3091 |
T4842 |
T4837 |
pobj |
deletion,After |
R3092 |
T4843 |
T4842 |
prep |
of,deletion |
R3093 |
T4844 |
T4845 |
nmod |
exons,3 |
R3094 |
T4845 |
T4843 |
pobj |
3,of |
R3095 |
T4846 |
T4845 |
cc |
and,3 |
R3096 |
T4847 |
T4845 |
conj |
4,3 |
R3097 |
T4848 |
T4842 |
punct |
", ",deletion |
R3098 |
T4849 |
T4850 |
dep |
which,results |
R3099 |
T4850 |
T4842 |
relcl |
results,deletion |
R3100 |
T4851 |
T4850 |
prep |
in,results |
R3101 |
T4852 |
T4853 |
det |
a,stop |
R3102 |
T4853 |
T4851 |
pobj |
stop,in |
R3103 |
T4854 |
T4853 |
nmod |
frameshift,stop |
R3104 |
T4855 |
T4854 |
cc |
and,frameshift |
R3105 |
T4856 |
T4857 |
amod |
premature,translation |
R3106 |
T4857 |
T4854 |
conj |
translation,frameshift |
R3107 |
T4858 |
T4838 |
punct |
", ",produced |
R3108 |
T4859 |
T4860 |
det |
no,protein |
R3109 |
T4860 |
T4838 |
nsubjpass |
protein,produced |
R3110 |
T4861 |
T4860 |
amod |
functional,protein |
R3111 |
T4862 |
T4860 |
nmod |
MTF,protein |
R3112 |
T4863 |
T4862 |
punct |
-,MTF |
R3113 |
T4864 |
T4862 |
nummod |
1,MTF |
R3114 |
T4865 |
T4838 |
aux |
can,produced |
R3115 |
T4866 |
T4838 |
auxpass |
be,produced |
R3116 |
T4867 |
T4838 |
punct |
.,produced |
R3117 |
T4869 |
T4870 |
prep |
For,received |
R3118 |
T4870 |
T4891 |
ccomp |
received,received |
R3119 |
T4871 |
T4869 |
pobj |
induction,For |
R3120 |
T4872 |
T4871 |
prep |
of,induction |
R3121 |
T4873 |
T4874 |
compound |
Cre,recombinase |
R3122 |
T4874 |
T4872 |
pobj |
recombinase,of |
R3123 |
T4875 |
T4870 |
punct |
", ",received |
R3124 |
T4876 |
T4877 |
nmod |
Mtf1,mice |
R3125 |
T4877 |
T4870 |
nsubj |
mice,received |
R3126 |
T4878 |
T4879 |
amod |
conditional,knockout |
R3127 |
T4879 |
T4877 |
compound |
knockout,mice |
R3128 |
T4880 |
T4877 |
acl |
harboring,mice |
R3129 |
T4881 |
T4882 |
det |
the,transgene |
R3130 |
T4882 |
T4880 |
dobj |
transgene,harboring |
R3131 |
T4883 |
T4884 |
compound |
Mx,cre |
R3132 |
T4884 |
T4882 |
compound |
cre,transgene |
R3133 |
T4885 |
T4884 |
punct |
-,cre |
R3134 |
T4886 |
T4882 |
punct |
(,transgene |
R3135 |
T4887 |
T4888 |
compound |
Mtf1Mx,cre |
R3136 |
T4888 |
T4882 |
appos |
cre,transgene |
R3137 |
T4889 |
T4888 |
punct |
-,cre |
R3138 |
T4890 |
T4870 |
punct |
),received |
R3139 |
T4892 |
T4893 |
nummod |
four,injections |
R3140 |
T4893 |
T4870 |
dobj |
injections,received |
R3141 |
T4894 |
T4893 |
amod |
intraperitoneal,injections |
R3142 |
T4895 |
T4896 |
compound |
pI,pC |
R3143 |
T4896 |
T4893 |
compound |
pC,injections |
R3144 |
T4897 |
T4896 |
punct |
–,pC |
R3145 |
T4898 |
T4870 |
prep |
at,received |
R3146 |
T4899 |
T4900 |
nummod |
3,day |
R3147 |
T4900 |
T4901 |
compound |
day,intervals |
R3148 |
T4901 |
T4898 |
pobj |
intervals,at |
R3149 |
T4902 |
T4903 |
punct |
(,induction |
R3150 |
T4903 |
T4870 |
parataxis |
induction,received |
R3151 |
T4904 |
T4905 |
compound |
pI,pC |
R3152 |
T4905 |
T4903 |
compound |
pC,induction |
R3153 |
T4906 |
T4905 |
punct |
–,pC |
R3154 |
T4907 |
T4903 |
punct |
),induction |
R3155 |
T4908 |
T4891 |
punct |
;,received |
R3156 |
T4909 |
T4910 |
compound |
control,littermates |
R3157 |
T4910 |
T4891 |
nsubj |
littermates,received |
R3158 |
T4911 |
T4910 |
prep |
without,littermates |
R3159 |
T4912 |
T4911 |
pobj |
transgene,without |
R3160 |
T4913 |
T4912 |
punct |
(,transgene |
R3161 |
T4914 |
T4912 |
appos |
Mtf1loxP,transgene |
R3162 |
T4915 |
T4891 |
punct |
),received |
R3163 |
T4916 |
T4917 |
amod |
similar,injections |
R3164 |
T4917 |
T4891 |
dobj |
injections,received |
R3165 |
T4918 |
T4891 |
punct |
.,received |
R3166 |
T4920 |
T4921 |
advcl |
Using,obtained |
R3167 |
T4922 |
T4923 |
compound |
RT,PCRs |
R3168 |
T4923 |
T4920 |
dobj |
PCRs,Using |
R3169 |
T4924 |
T4923 |
punct |
–,PCRs |
R3170 |
T4925 |
T4926 |
punct |
(,1b |
R3171 |
T4926 |
T4920 |
parataxis |
1b,Using |
R3172 |
T4927 |
T4926 |
compound |
Figure,1b |
R3173 |
T4928 |
T4926 |
punct |
),1b |
R3174 |
T4929 |
T4921 |
punct |
", ",obtained |
R3175 |
T4930 |
T4931 |
det |
a,product |
R3176 |
T4931 |
T4921 |
nsubjpass |
product,obtained |
R3177 |
T4932 |
T4931 |
amod |
shortened,product |
R3178 |
T4933 |
T4921 |
auxpass |
was,obtained |
R3179 |
T4934 |
T4921 |
prep |
with,obtained |
R3180 |
T4935 |
T4934 |
pobj |
RNA,with |
R3181 |
T4936 |
T4935 |
prep |
from,RNA |
R3182 |
T4937 |
T4938 |
compound |
Mtf1Mx,cre |
R3183 |
T4938 |
T4940 |
compound |
cre,livers |
R3184 |
T4939 |
T4938 |
punct |
-,cre |
R3185 |
T4940 |
T4936 |
pobj |
livers,from |
R3186 |
T4941 |
T4921 |
punct |
", ",obtained |
R3187 |
T4942 |
T4921 |
advcl |
indicating,obtained |
R3188 |
T4943 |
T4944 |
det |
a,excision |
R3189 |
T4944 |
T4942 |
dobj |
excision,indicating |
R3190 |
T4945 |
T4944 |
amod |
successful,excision |
R3191 |
T4946 |
T4944 |
prep |
of,excision |
R3192 |
T4947 |
T4948 |
nmod |
exons,3 |
R3193 |
T4948 |
T4946 |
pobj |
3,of |
R3194 |
T4949 |
T4948 |
cc |
and,3 |
R3195 |
T4950 |
T4948 |
conj |
4,3 |
R3196 |
T4951 |
T4948 |
prep |
of,3 |
R3197 |
T4952 |
T4951 |
pobj |
Mtf1,of |
R3198 |
T4953 |
T4942 |
prep |
in,indicating |
R3199 |
T4954 |
T4955 |
det |
these,animals |
R3200 |
T4955 |
T4953 |
pobj |
animals,in |
R3201 |
T4956 |
T4921 |
punct |
.,obtained |
R3202 |
T4958 |
T4959 |
prep |
On,observed |
R3203 |
T4960 |
T4961 |
amod |
close,examination |
R3204 |
T4961 |
T4958 |
pobj |
examination,On |
R3205 |
T4962 |
T4959 |
punct |
", ",observed |
R3206 |
T4963 |
T4964 |
det |
a,band |
R3207 |
T4964 |
T4959 |
nsubjpass |
band,observed |
R3208 |
T4965 |
T4966 |
advmod |
very,faint |
R3209 |
T4966 |
T4964 |
amod |
faint,band |
R3210 |
T4967 |
T4964 |
relcl |
similar,band |
R3211 |
T4968 |
T4967 |
prep |
in,similar |
R3212 |
T4969 |
T4968 |
pobj |
size,in |
R3213 |
T4970 |
T4967 |
prep |
to,similar |
R3214 |
T4971 |
T4972 |
amod |
full,length |
R3215 |
T4972 |
T4974 |
compound |
length,signal |
R3216 |
T4973 |
T4972 |
punct |
-,length |
R3217 |
T4974 |
T4970 |
pobj |
signal,to |
R3218 |
T4975 |
T4959 |
auxpass |
was,observed |
R3219 |
T4976 |
T4959 |
advmod |
also,observed |
R3220 |
T4977 |
T4959 |
prep |
in,observed |
R3221 |
T4978 |
T4979 |
det |
those,mice |
R3222 |
T4979 |
T4977 |
pobj |
mice,in |
R3223 |
T4980 |
T4959 |
punct |
", ",observed |
R3224 |
T4981 |
T4982 |
advmod |
probably,due |
R3225 |
T4982 |
T4959 |
prep |
due,observed |
R3226 |
T4983 |
T4982 |
pcomp |
to,due |
R3227 |
T4984 |
T4985 |
det |
a,amount |
R3228 |
T4985 |
T4982 |
pobj |
amount,due |
R3229 |
T4986 |
T4985 |
amod |
low,amount |
R3230 |
T4987 |
T4985 |
prep |
of,amount |
R3231 |
T4988 |
T4989 |
amod |
residual,mRNA |
R3232 |
T4989 |
T4987 |
pobj |
mRNA,of |
R3233 |
T4990 |
T4991 |
amod |
full,length |
R3234 |
T4991 |
T4989 |
compound |
length,mRNA |
R3235 |
T4992 |
T4991 |
punct |
-,length |
R3236 |
T4993 |
T4989 |
compound |
Mtf1,mRNA |
R3237 |
T4994 |
T4959 |
punct |
.,observed |
R3238 |
T4996 |
T4997 |
det |
The,level |
R3239 |
T4997 |
T4998 |
nsubjpass |
level,examined |
R3240 |
T4998 |
T5006 |
ccomp |
examined,was |
R3241 |
T4999 |
T4997 |
prep |
of,level |
R3242 |
T5000 |
T5001 |
amod |
functional,protein |
R3243 |
T5001 |
T4999 |
pobj |
protein,of |
R3244 |
T5002 |
T5001 |
nmod |
MTF,protein |
R3245 |
T5003 |
T5002 |
punct |
-,MTF |
R3246 |
T5004 |
T5002 |
nummod |
1,MTF |
R3247 |
T5005 |
T4998 |
auxpass |
was,examined |
R3248 |
T5007 |
T4998 |
prep |
by,examined |
R3249 |
T5008 |
T5007 |
pobj |
EMSA,by |
R3250 |
T5009 |
T5010 |
punct |
(,1c |
R3251 |
T5010 |
T4998 |
parataxis |
1c,examined |
R3252 |
T5011 |
T5010 |
compound |
Figure,1c |
R3253 |
T5012 |
T5010 |
punct |
),1c |
R3254 |
T5013 |
T5006 |
punct |
: ,was |
R3255 |
T5014 |
T5015 |
nmod |
MTF,complex |
R3256 |
T5015 |
T5006 |
nsubj |
complex,was |
R3257 |
T5016 |
T5014 |
punct |
-,MTF |
R3258 |
T5017 |
T5014 |
nummod |
1,MTF |
R3259 |
T5018 |
T5015 |
compound |
protein,complex |
R3260 |
T5019 |
T5015 |
punct |
–,complex |
R3261 |
T5020 |
T5015 |
compound |
DNA,complex |
R3262 |
T5021 |
T5006 |
acomp |
detectable,was |
R3263 |
T5022 |
T5021 |
prep |
with,detectable |
R3264 |
T5023 |
T5024 |
compound |
liver,extract |
R3265 |
T5024 |
T5022 |
pobj |
extract,with |
R3266 |
T5025 |
T5024 |
compound |
protein,extract |
R3267 |
T5026 |
T5024 |
prep |
from,extract |
R3268 |
T5027 |
T5028 |
det |
an,mouse |
R3269 |
T5028 |
T5026 |
pobj |
mouse,from |
R3270 |
T5029 |
T5028 |
compound |
Mtf1loxP,mouse |
R3271 |
T5030 |
T5028 |
compound |
control,mouse |
R3272 |
T5031 |
T5006 |
punct |
", ",was |
R3273 |
T5032 |
T5006 |
cc |
but,was |
R3274 |
T5033 |
T5034 |
det |
no,protein |
R3275 |
T5034 |
T5039 |
nsubjpass |
protein,observed |
R3276 |
T5035 |
T5034 |
amod |
functional,protein |
R3277 |
T5036 |
T5037 |
npadvmod |
MRE,binding |
R3278 |
T5037 |
T5034 |
amod |
binding,protein |
R3279 |
T5038 |
T5037 |
punct |
-,binding |
R3280 |
T5039 |
T5006 |
conj |
observed,was |
R3281 |
T5040 |
T5039 |
auxpass |
was,observed |
R3282 |
T5041 |
T5039 |
prep |
with,observed |
R3283 |
T5042 |
T5043 |
det |
an,sample |
R3284 |
T5043 |
T5041 |
pobj |
sample,with |
R3285 |
T5044 |
T5045 |
compound |
Mtf1Mx,cre |
R3286 |
T5045 |
T5043 |
compound |
cre,sample |
R3287 |
T5046 |
T5045 |
punct |
-,cre |
R3288 |
T5047 |
T5006 |
punct |
.,was |
R3289 |
T5049 |
T5050 |
advmod |
Thus,was |
R3290 |
T5051 |
T5050 |
punct |
", ",was |
R3291 |
T5052 |
T5050 |
nsubj |
deletion,was |
R3292 |
T5053 |
T5052 |
prep |
of,deletion |
R3293 |
T5054 |
T5055 |
nmod |
exons,3 |
R3294 |
T5055 |
T5053 |
pobj |
3,of |
R3295 |
T5056 |
T5055 |
cc |
and,3 |
R3296 |
T5057 |
T5055 |
conj |
4,3 |
R3297 |
T5058 |
T5055 |
prep |
of,3 |
R3298 |
T5059 |
T5058 |
pobj |
Mtf1,of |
R3299 |
T5060 |
T5052 |
prep |
in,deletion |
R3300 |
T5061 |
T5062 |
det |
the,liver |
R3301 |
T5062 |
T5060 |
pobj |
liver,in |
R3302 |
T5063 |
T5062 |
prep |
of,liver |
R3303 |
T5064 |
T5065 |
compound |
Mtf1Mx,cre |
R3304 |
T5065 |
T5067 |
compound |
cre,mice |
R3305 |
T5066 |
T5065 |
punct |
-,cre |
R3306 |
T5067 |
T5063 |
pobj |
mice,of |
R3307 |
T5068 |
T5069 |
advmod |
virtually,complete |
R3308 |
T5069 |
T5050 |
acomp |
complete,was |
R3309 |
T5070 |
T5050 |
punct |
.,was |
R3310 |
T5072 |
T5073 |
det |
All,mice |
R3311 |
T5073 |
T5079 |
nsubj |
mice,were |
R3312 |
T5074 |
T5073 |
amod |
examined,mice |
R3313 |
T5075 |
T5076 |
npadvmod |
liver,specific |
R3314 |
T5076 |
T5073 |
amod |
specific,mice |
R3315 |
T5077 |
T5076 |
punct |
-,specific |
R3316 |
T5078 |
T5073 |
compound |
knockout,mice |
R3317 |
T5080 |
T5079 |
acomp |
viable,were |
R3318 |
T5081 |
T5079 |
prep |
under,were |
R3319 |
T5082 |
T5083 |
compound |
laboratory,conditions |
R3320 |
T5083 |
T5081 |
pobj |
conditions,under |
R3321 |
T5084 |
T5079 |
cc |
and,were |
R3322 |
T5085 |
T5079 |
conj |
appeared,were |
R3323 |
T5086 |
T5085 |
oprd |
normal,appeared |
R3324 |
T5087 |
T5079 |
punct |
.,were |