Id |
Subject |
Object |
Predicate |
Lexical cue |
T258 |
0-247 |
sentence |
denotes |
Metal-responsive transcription factor 1 (MTF-1) regulates expression of its target genes in response to various stress conditions, notably heavy metal load, via binding to metal response elements (MREs) in the respective enhancer/promoter regions. |
T259 |
0-5 |
NN |
denotes |
Metal |
T260 |
6-16 |
JJ |
denotes |
responsive |
T261 |
5-6 |
HYPH |
denotes |
- |
T262 |
31-37 |
NN |
denotes |
factor |
T263 |
17-30 |
NN |
denotes |
transcription |
T264 |
48-57 |
VBZ |
denotes |
regulates |
T265 |
38-39 |
CD |
denotes |
1 |
T266 |
40-41 |
-LRB- |
denotes |
( |
T267 |
41-44 |
NN |
denotes |
MTF |
T268 |
44-45 |
HYPH |
denotes |
- |
T269 |
45-46 |
CD |
denotes |
1 |
T270 |
46-47 |
-RRB- |
denotes |
) |
T271 |
58-68 |
NN |
denotes |
expression |
T272 |
69-71 |
IN |
denotes |
of |
T273 |
72-75 |
PRP$ |
denotes |
its |
T274 |
83-88 |
NNS |
denotes |
genes |
T275 |
76-82 |
NN |
denotes |
target |
T276 |
89-91 |
IN |
denotes |
in |
T277 |
92-100 |
NN |
denotes |
response |
T278 |
101-103 |
IN |
denotes |
to |
T279 |
104-111 |
JJ |
denotes |
various |
T280 |
119-129 |
NNS |
denotes |
conditions |
T281 |
112-118 |
NN |
denotes |
stress |
T282 |
129-131 |
, |
denotes |
, |
T283 |
131-138 |
RB |
denotes |
notably |
T284 |
151-155 |
NN |
denotes |
load |
T285 |
139-144 |
JJ |
denotes |
heavy |
T286 |
145-150 |
NN |
denotes |
metal |
T287 |
155-157 |
, |
denotes |
, |
T288 |
157-160 |
IN |
denotes |
via |
T289 |
161-168 |
NN |
denotes |
binding |
T290 |
169-171 |
IN |
denotes |
to |
T291 |
172-177 |
NN |
denotes |
metal |
T292 |
187-195 |
NNS |
denotes |
elements |
T293 |
178-186 |
NN |
denotes |
response |
T294 |
196-197 |
-LRB- |
denotes |
( |
T295 |
197-201 |
NNS |
denotes |
MREs |
T296 |
201-202 |
-RRB- |
denotes |
) |
T297 |
203-205 |
IN |
denotes |
in |
T298 |
206-209 |
DT |
denotes |
the |
T299 |
239-246 |
NNS |
denotes |
regions |
T300 |
210-220 |
JJ |
denotes |
respective |
T301 |
221-229 |
NN |
denotes |
enhancer |
T302 |
230-238 |
NN |
denotes |
promoter |
T303 |
229-230 |
HYPH |
denotes |
/ |
T304 |
246-247 |
. |
denotes |
. |
T305 |
247-319 |
sentence |
denotes |
Furthermore, it serves a vital function in embryonic liver development. |
T306 |
248-259 |
RB |
denotes |
Furthermore |
T307 |
264-270 |
VBZ |
denotes |
serves |
T308 |
259-261 |
, |
denotes |
, |
T309 |
261-263 |
PRP |
denotes |
it |
T310 |
271-272 |
DT |
denotes |
a |
T311 |
279-287 |
NN |
denotes |
function |
T312 |
273-278 |
JJ |
denotes |
vital |
T313 |
288-290 |
IN |
denotes |
in |
T314 |
291-300 |
JJ |
denotes |
embryonic |
T315 |
307-318 |
NN |
denotes |
development |
T316 |
301-306 |
NN |
denotes |
liver |
T317 |
318-319 |
. |
denotes |
. |
T318 |
319-400 |
sentence |
denotes |
However, targeted deletion of Mtf1 in the liver after birth is no longer lethal. |
T319 |
320-327 |
RB |
denotes |
However |
T320 |
380-382 |
VBZ |
denotes |
is |
T321 |
327-329 |
, |
denotes |
, |
T322 |
329-337 |
VBN |
denotes |
targeted |
T323 |
338-346 |
NN |
denotes |
deletion |
T324 |
347-349 |
IN |
denotes |
of |
T325 |
350-354 |
NN |
denotes |
Mtf1 |
T326 |
355-357 |
IN |
denotes |
in |
T327 |
358-361 |
DT |
denotes |
the |
T328 |
362-367 |
NN |
denotes |
liver |
T329 |
368-373 |
IN |
denotes |
after |
T330 |
374-379 |
NN |
denotes |
birth |
T331 |
383-385 |
RB |
denotes |
no |
T332 |
386-392 |
RB |
denotes |
longer |
T333 |
393-399 |
JJ |
denotes |
lethal |
T334 |
399-400 |
. |
denotes |
. |
T335 |
400-553 |
sentence |
denotes |
For this study, Mtf1 conditional knockout mice and control littermates were both mock- or cadmium-treated and liver-specific transcription was analyzed. |
T336 |
401-404 |
IN |
denotes |
For |
T337 |
499-506 |
VBN |
denotes |
treated |
T338 |
405-409 |
DT |
denotes |
this |
T339 |
410-415 |
NN |
denotes |
study |
T340 |
415-417 |
, |
denotes |
, |
T341 |
417-421 |
NN |
denotes |
Mtf1 |
T342 |
443-447 |
NNS |
denotes |
mice |
T343 |
422-433 |
JJ |
denotes |
conditional |
T344 |
434-442 |
NN |
denotes |
knockout |
T345 |
448-451 |
CC |
denotes |
and |
T346 |
452-459 |
NN |
denotes |
control |
T347 |
460-471 |
NNS |
denotes |
littermates |
T348 |
472-476 |
VBD |
denotes |
were |
T349 |
477-481 |
CC |
denotes |
both |
T350 |
482-486 |
JJ |
denotes |
mock |
T351 |
486-487 |
HYPH |
denotes |
- |
T352 |
488-490 |
CC |
denotes |
or |
T353 |
491-498 |
NN |
denotes |
cadmium |
T354 |
498-499 |
HYPH |
denotes |
- |
T355 |
507-510 |
CC |
denotes |
and |
T356 |
511-516 |
NN |
denotes |
liver |
T357 |
517-525 |
JJ |
denotes |
specific |
T358 |
516-517 |
HYPH |
denotes |
- |
T359 |
526-539 |
NN |
denotes |
transcription |
T360 |
544-552 |
VBN |
denotes |
analyzed |
T361 |
540-543 |
VBD |
denotes |
was |
T362 |
552-553 |
. |
denotes |
. |
T363 |
553-686 |
sentence |
denotes |
Besides the well-characterized metallothionein genes, several new MTF-1 target genes with MRE motifs in the promoter region emerged. |
T364 |
554-561 |
IN |
denotes |
Besides |
T366 |
562-565 |
DT |
denotes |
the |
T367 |
601-606 |
NNS |
denotes |
genes |
T368 |
566-570 |
RB |
denotes |
well |
T369 |
571-584 |
VBN |
denotes |
characterized |
T370 |
570-571 |
HYPH |
denotes |
- |
T371 |
585-600 |
NN |
denotes |
metallothionein |
T372 |
606-608 |
, |
denotes |
, |
T373 |
608-615 |
JJ |
denotes |
several |
T374 |
633-638 |
NNS |
denotes |
genes |
T375 |
616-619 |
JJ |
denotes |
new |
T376 |
620-623 |
NN |
denotes |
MTF |
T377 |
623-624 |
HYPH |
denotes |
- |
T378 |
624-625 |
CD |
denotes |
1 |
T379 |
626-632 |
NN |
denotes |
target |
T380 |
639-643 |
IN |
denotes |
with |
T381 |
644-647 |
NN |
denotes |
MRE |
T382 |
648-654 |
NNS |
denotes |
motifs |
T383 |
655-657 |
IN |
denotes |
in |
T384 |
658-661 |
DT |
denotes |
the |
T385 |
671-677 |
NN |
denotes |
region |
T386 |
662-670 |
NN |
denotes |
promoter |
T387 |
685-686 |
. |
denotes |
. |
T388 |
686-901 |
sentence |
denotes |
MTF-1 is required for the basal expression of selenoprotein W, muscle 1 gene (Sepw1) that encodes a glutathione-binding and putative antioxidant protein, supporting a role of MTF-1 in the oxidative stress response. |
T389 |
687-690 |
NN |
denotes |
MTF |
T390 |
696-704 |
VBN |
denotes |
required |
T391 |
690-691 |
HYPH |
denotes |
- |
T392 |
691-692 |
CD |
denotes |
1 |
T393 |
693-695 |
VBZ |
denotes |
is |
T394 |
705-708 |
IN |
denotes |
for |
T395 |
709-712 |
DT |
denotes |
the |
T396 |
719-729 |
NN |
denotes |
expression |
T397 |
713-718 |
JJ |
denotes |
basal |
T398 |
730-732 |
IN |
denotes |
of |
T399 |
733-746 |
NN |
denotes |
selenoprotein |
T400 |
759-763 |
NN |
denotes |
gene |
T401 |
747-748 |
NN |
denotes |
W |
T402 |
748-750 |
, |
denotes |
, |
T403 |
750-756 |
NN |
denotes |
muscle |
T404 |
757-758 |
CD |
denotes |
1 |
T405 |
764-765 |
-LRB- |
denotes |
( |
T406 |
765-770 |
NN |
denotes |
Sepw1 |
T407 |
770-771 |
-RRB- |
denotes |
) |
T408 |
772-776 |
WDT |
denotes |
that |
T409 |
777-784 |
VBZ |
denotes |
encodes |
T410 |
785-786 |
DT |
denotes |
a |
T411 |
832-839 |
NN |
denotes |
protein |
T412 |
787-798 |
NN |
denotes |
glutathione |
T413 |
799-806 |
VBG |
denotes |
binding |
T414 |
798-799 |
HYPH |
denotes |
- |
T415 |
807-810 |
CC |
denotes |
and |
T416 |
811-819 |
JJ |
denotes |
putative |
T417 |
820-831 |
NN |
denotes |
antioxidant |
T418 |
839-841 |
, |
denotes |
, |
T419 |
841-851 |
VBG |
denotes |
supporting |
T420 |
852-853 |
DT |
denotes |
a |
T421 |
854-858 |
NN |
denotes |
role |
T422 |
859-861 |
IN |
denotes |
of |
T423 |
862-865 |
NN |
denotes |
MTF |
T424 |
865-866 |
HYPH |
denotes |
- |
T425 |
866-867 |
CD |
denotes |
1 |
T426 |
868-870 |
IN |
denotes |
in |
T427 |
871-874 |
DT |
denotes |
the |
T428 |
892-900 |
NN |
denotes |
response |
T429 |
875-884 |
JJ |
denotes |
oxidative |
T430 |
885-891 |
NN |
denotes |
stress |
T431 |
900-901 |
. |
denotes |
. |
T432 |
901-1090 |
sentence |
denotes |
Furthermore, MTF-1 mediates the cadmium-induced expression of N-myc downstream regulated gene 1 (Ndrg1), which is induced by several stress conditions and is overexpressed in many cancers. |
T433 |
902-913 |
RB |
denotes |
Furthermore |
T434 |
921-929 |
VBZ |
denotes |
mediates |
T435 |
913-915 |
, |
denotes |
, |
T436 |
915-918 |
NN |
denotes |
MTF |
T437 |
918-919 |
HYPH |
denotes |
- |
T438 |
919-920 |
CD |
denotes |
1 |
T439 |
930-933 |
DT |
denotes |
the |
T440 |
950-960 |
NN |
denotes |
expression |
T441 |
934-941 |
NN |
denotes |
cadmium |
T442 |
942-949 |
VBN |
denotes |
induced |
T443 |
941-942 |
HYPH |
denotes |
- |
T444 |
961-963 |
IN |
denotes |
of |
T445 |
964-965 |
NN |
denotes |
N |
T446 |
966-969 |
NN |
denotes |
myc |
T447 |
965-966 |
HYPH |
denotes |
- |
T448 |
991-995 |
NN |
denotes |
gene |
T449 |
970-980 |
RB |
denotes |
downstream |
T450 |
981-990 |
VBN |
denotes |
regulated |
T451 |
996-997 |
CD |
denotes |
1 |
T452 |
998-999 |
-LRB- |
denotes |
( |
T453 |
999-1004 |
NN |
denotes |
Ndrg1 |
T454 |
1004-1005 |
-RRB- |
denotes |
) |
T455 |
1005-1007 |
, |
denotes |
, |
T456 |
1007-1012 |
WDT |
denotes |
which |
T457 |
1016-1023 |
VBN |
denotes |
induced |
T458 |
1013-1015 |
VBZ |
denotes |
is |
T459 |
1024-1026 |
IN |
denotes |
by |
T460 |
1027-1034 |
JJ |
denotes |
several |
T461 |
1042-1052 |
NNS |
denotes |
conditions |
T462 |
1035-1041 |
NN |
denotes |
stress |
T463 |
1053-1056 |
CC |
denotes |
and |
T464 |
1057-1059 |
VBZ |
denotes |
is |
T465 |
1060-1073 |
VBN |
denotes |
overexpressed |
T466 |
1074-1076 |
IN |
denotes |
in |
T467 |
1077-1081 |
JJ |
denotes |
many |
T468 |
1082-1089 |
NNS |
denotes |
cancers |
T469 |
1089-1090 |
. |
denotes |
. |
T470 |
1090-1241 |
sentence |
denotes |
MTF-1 is also involved in the cadmium response of cysteine- and glycine-rich protein 1 gene (Csrp1), which is implicated in cytoskeletal organization. |
T471 |
1091-1094 |
NN |
denotes |
MTF |
T472 |
1105-1113 |
VBN |
denotes |
involved |
T473 |
1094-1095 |
HYPH |
denotes |
- |
T474 |
1095-1096 |
CD |
denotes |
1 |
T475 |
1097-1099 |
VBZ |
denotes |
is |
T476 |
1100-1104 |
RB |
denotes |
also |
T477 |
1114-1116 |
IN |
denotes |
in |
T478 |
1117-1120 |
DT |
denotes |
the |
T479 |
1129-1137 |
NN |
denotes |
response |
T480 |
1121-1128 |
NN |
denotes |
cadmium |
T481 |
1138-1140 |
IN |
denotes |
of |
T482 |
1141-1149 |
NN |
denotes |
cysteine |
T483 |
1163-1167 |
JJ |
denotes |
rich |
T484 |
1149-1150 |
HYPH |
denotes |
- |
T485 |
1151-1154 |
CC |
denotes |
and |
T486 |
1155-1162 |
NN |
denotes |
glycine |
T487 |
1162-1163 |
HYPH |
denotes |
- |
T488 |
1178-1182 |
NN |
denotes |
gene |
T489 |
1168-1175 |
NN |
denotes |
protein |
T490 |
1176-1177 |
CD |
denotes |
1 |
T491 |
1183-1184 |
-LRB- |
denotes |
( |
T492 |
1184-1189 |
NN |
denotes |
Csrp1 |
T493 |
1189-1190 |
-RRB- |
denotes |
) |
T494 |
1190-1192 |
, |
denotes |
, |
T495 |
1192-1197 |
WDT |
denotes |
which |
T496 |
1201-1211 |
VBN |
denotes |
implicated |
T497 |
1198-1200 |
VBZ |
denotes |
is |
T498 |
1212-1214 |
IN |
denotes |
in |
T499 |
1215-1227 |
JJ |
denotes |
cytoskeletal |
T500 |
1228-1240 |
NN |
denotes |
organization |
T501 |
1240-1241 |
. |
denotes |
. |
T502 |
1241-1333 |
sentence |
denotes |
In contrast, MTF-1 represses the basal expression of Slc39a10, a putative zinc transporter. |
T503 |
1242-1244 |
IN |
denotes |
In |
T504 |
1261-1270 |
VBZ |
denotes |
represses |
T505 |
1245-1253 |
NN |
denotes |
contrast |
T506 |
1253-1255 |
, |
denotes |
, |
T507 |
1255-1258 |
NN |
denotes |
MTF |
T508 |
1258-1259 |
HYPH |
denotes |
- |
T509 |
1259-1260 |
CD |
denotes |
1 |
T510 |
1271-1274 |
DT |
denotes |
the |
T511 |
1281-1291 |
NN |
denotes |
expression |
T512 |
1275-1280 |
JJ |
denotes |
basal |
T513 |
1292-1294 |
IN |
denotes |
of |
T514 |
1295-1303 |
NN |
denotes |
Slc39a10 |
T515 |
1303-1305 |
, |
denotes |
, |
T516 |
1305-1306 |
DT |
denotes |
a |
T517 |
1321-1332 |
NN |
denotes |
transporter |
T518 |
1307-1315 |
JJ |
denotes |
putative |
T519 |
1316-1320 |
NN |
denotes |
zinc |
T520 |
1332-1333 |
. |
denotes |
. |
T521 |
1333-1506 |
sentence |
denotes |
In a pathway independent of MTF-1, cadmium also induced the transcription of genes involved in the synthesis and regeneration of glutathione, a cadmium-binding antioxidant. |
T522 |
1334-1336 |
IN |
denotes |
In |
T523 |
1382-1389 |
VBD |
denotes |
induced |
T524 |
1337-1338 |
DT |
denotes |
a |
T525 |
1339-1346 |
NN |
denotes |
pathway |
T526 |
1347-1358 |
JJ |
denotes |
independent |
T527 |
1359-1361 |
IN |
denotes |
of |
T528 |
1362-1365 |
NN |
denotes |
MTF |
T529 |
1365-1366 |
HYPH |
denotes |
- |
T530 |
1366-1367 |
CD |
denotes |
1 |
T531 |
1367-1369 |
, |
denotes |
, |
T532 |
1369-1376 |
NN |
denotes |
cadmium |
T533 |
1377-1381 |
RB |
denotes |
also |
T534 |
1390-1393 |
DT |
denotes |
the |
T535 |
1394-1407 |
NN |
denotes |
transcription |
T536 |
1408-1410 |
IN |
denotes |
of |
T537 |
1411-1416 |
NNS |
denotes |
genes |
T538 |
1417-1425 |
VBN |
denotes |
involved |
T539 |
1426-1428 |
IN |
denotes |
in |
T540 |
1429-1432 |
DT |
denotes |
the |
T541 |
1433-1442 |
NN |
denotes |
synthesis |
T542 |
1443-1446 |
CC |
denotes |
and |
T543 |
1447-1459 |
NN |
denotes |
regeneration |
T544 |
1460-1462 |
IN |
denotes |
of |
T545 |
1463-1474 |
NN |
denotes |
glutathione |
T546 |
1474-1476 |
, |
denotes |
, |
T547 |
1476-1477 |
DT |
denotes |
a |
T548 |
1494-1505 |
NN |
denotes |
antioxidant |
T549 |
1478-1485 |
NN |
denotes |
cadmium |
T550 |
1486-1493 |
VBG |
denotes |
binding |
T551 |
1485-1486 |
HYPH |
denotes |
- |
T552 |
1505-1506 |
. |
denotes |
. |
T553 |
1506-1732 |
sentence |
denotes |
These data provide strong evidence for two major branches of cellular anti-cadmium defense, one via MTF-1 and its target genes, notably metallothioneins, the other via glutathione, with an apparent overlap in selenoprotein W. |
T554 |
1507-1512 |
DT |
denotes |
These |
T555 |
1513-1517 |
NNS |
denotes |
data |
T556 |
1518-1525 |
VBP |
denotes |
provide |
T557 |
1526-1532 |
JJ |
denotes |
strong |
T558 |
1533-1541 |
NN |
denotes |
evidence |
T559 |
1542-1545 |
IN |
denotes |
for |
T560 |
1546-1549 |
CD |
denotes |
two |
T561 |
1556-1564 |
NNS |
denotes |
branches |
T562 |
1550-1555 |
JJ |
denotes |
major |
T563 |
1565-1567 |
IN |
denotes |
of |
T564 |
1568-1576 |
JJ |
denotes |
cellular |
T565 |
1590-1597 |
NN |
denotes |
defense |
T566 |
1577-1589 |
JJ |
denotes |
anti-cadmium |
T567 |
1597-1599 |
, |
denotes |
, |
T568 |
1599-1602 |
CD |
denotes |
one |
T569 |
1603-1606 |
IN |
denotes |
via |
T570 |
1607-1610 |
NN |
denotes |
MTF |
T571 |
1610-1611 |
HYPH |
denotes |
- |
T572 |
1611-1612 |
CD |
denotes |
1 |
T573 |
1613-1616 |
CC |
denotes |
and |
T574 |
1617-1620 |
PRP$ |
denotes |
its |
T575 |
1628-1633 |
NNS |
denotes |
genes |
T576 |
1621-1627 |
NN |
denotes |
target |
T577 |
1633-1635 |
, |
denotes |
, |
T578 |
1635-1642 |
RB |
denotes |
notably |
T579 |
1643-1659 |
NNS |
denotes |
metallothioneins |
T580 |
1659-1661 |
, |
denotes |
, |
T581 |
1661-1664 |
DT |
denotes |
the |
T582 |
1665-1670 |
JJ |
denotes |
other |
T583 |
1671-1674 |
IN |
denotes |
via |
T584 |
1675-1686 |
NN |
denotes |
glutathione |
T585 |
1686-1688 |
, |
denotes |
, |
T586 |
1688-1692 |
IN |
denotes |
with |
T587 |
1693-1695 |
DT |
denotes |
an |
T588 |
1705-1712 |
NN |
denotes |
overlap |
T589 |
1696-1704 |
JJ |
denotes |
apparent |
T590 |
1713-1715 |
IN |
denotes |
in |
T591 |
1716-1729 |
NN |
denotes |
selenoprotein |
T592 |
1730-1731 |
NN |
denotes |
W |
T593 |
1731-1732 |
. |
denotes |
. |
T365 |
678-685 |
VBD |
denotes |
emerged |
R41 |
T279 |
T280 |
amod |
various,conditions |
R42 |
T280 |
T278 |
pobj |
conditions,to |
R22 |
T259 |
T260 |
npadvmod |
Metal,responsive |
R23 |
T260 |
T262 |
amod |
responsive,factor |
R24 |
T261 |
T260 |
punct |
-,responsive |
R25 |
T262 |
T264 |
nsubj |
factor,regulates |
R26 |
T263 |
T262 |
compound |
transcription,factor |
R27 |
T265 |
T262 |
nummod |
1,factor |
R28 |
T266 |
T262 |
punct |
(,factor |
R29 |
T267 |
T262 |
appos |
MTF,factor |
R30 |
T268 |
T267 |
punct |
-,MTF |
R31 |
T269 |
T267 |
nummod |
1,MTF |
R32 |
T270 |
T264 |
punct |
),regulates |
R33 |
T271 |
T264 |
dobj |
expression,regulates |
R34 |
T272 |
T271 |
prep |
of,expression |
R35 |
T273 |
T274 |
poss |
its,genes |
R36 |
T274 |
T272 |
pobj |
genes,of |
R37 |
T275 |
T274 |
compound |
target,genes |
R38 |
T276 |
T264 |
prep |
in,regulates |
R39 |
T277 |
T276 |
pobj |
response,in |
R40 |
T278 |
T277 |
prep |
to,response |
R43 |
T281 |
T280 |
compound |
stress,conditions |
R44 |
T282 |
T280 |
punct |
", ",conditions |
R45 |
T283 |
T284 |
advmod |
notably,load |
R46 |
T284 |
T280 |
appos |
load,conditions |
R47 |
T285 |
T286 |
amod |
heavy,metal |
R48 |
T286 |
T284 |
compound |
metal,load |
R49 |
T287 |
T264 |
punct |
", ",regulates |
R50 |
T288 |
T264 |
prep |
via,regulates |
R51 |
T289 |
T288 |
pobj |
binding,via |
R52 |
T290 |
T289 |
prep |
to,binding |
R53 |
T291 |
T292 |
compound |
metal,elements |
R54 |
T292 |
T290 |
pobj |
elements,to |
R55 |
T293 |
T292 |
compound |
response,elements |
R56 |
T294 |
T292 |
punct |
(,elements |
R57 |
T295 |
T292 |
appos |
MREs,elements |
R58 |
T296 |
T289 |
punct |
),binding |
R59 |
T297 |
T289 |
prep |
in,binding |
R60 |
T298 |
T299 |
det |
the,regions |
R61 |
T299 |
T297 |
pobj |
regions,in |
R62 |
T300 |
T299 |
amod |
respective,regions |
R63 |
T301 |
T302 |
compound |
enhancer,promoter |
R64 |
T302 |
T299 |
compound |
promoter,regions |
R65 |
T303 |
T302 |
punct |
/,promoter |
R66 |
T304 |
T264 |
punct |
.,regulates |
R67 |
T306 |
T307 |
advmod |
Furthermore,serves |
R68 |
T308 |
T307 |
punct |
", ",serves |
R69 |
T309 |
T307 |
nsubj |
it,serves |
R70 |
T310 |
T311 |
det |
a,function |
R71 |
T311 |
T307 |
dobj |
function,serves |
R72 |
T312 |
T311 |
amod |
vital,function |
R73 |
T313 |
T307 |
prep |
in,serves |
R74 |
T314 |
T315 |
amod |
embryonic,development |
R75 |
T315 |
T313 |
pobj |
development,in |
R76 |
T316 |
T315 |
compound |
liver,development |
R77 |
T317 |
T307 |
punct |
.,serves |
R78 |
T319 |
T320 |
advmod |
However,is |
R79 |
T321 |
T320 |
punct |
", ",is |
R80 |
T322 |
T323 |
amod |
targeted,deletion |
R81 |
T323 |
T320 |
nsubj |
deletion,is |
R82 |
T324 |
T323 |
prep |
of,deletion |
R83 |
T325 |
T324 |
pobj |
Mtf1,of |
R84 |
T326 |
T323 |
prep |
in,deletion |
R85 |
T327 |
T328 |
det |
the,liver |
R86 |
T328 |
T326 |
pobj |
liver,in |
R87 |
T329 |
T323 |
prep |
after,deletion |
R88 |
T330 |
T329 |
pobj |
birth,after |
R89 |
T331 |
T332 |
neg |
no,longer |
R90 |
T332 |
T320 |
advmod |
longer,is |
R91 |
T333 |
T320 |
acomp |
lethal,is |
R92 |
T334 |
T320 |
punct |
.,is |
R93 |
T336 |
T337 |
prep |
For,treated |
R94 |
T338 |
T339 |
det |
this,study |
R95 |
T339 |
T336 |
pobj |
study,For |
R96 |
T340 |
T337 |
punct |
", ",treated |
R97 |
T341 |
T342 |
nmod |
Mtf1,mice |
R98 |
T342 |
T337 |
nsubjpass |
mice,treated |
R99 |
T343 |
T344 |
amod |
conditional,knockout |
R100 |
T344 |
T342 |
compound |
knockout,mice |
R101 |
T345 |
T342 |
cc |
and,mice |
R102 |
T346 |
T347 |
compound |
control,littermates |
R103 |
T347 |
T342 |
conj |
littermates,mice |
R104 |
T348 |
T337 |
auxpass |
were,treated |
R105 |
T349 |
T350 |
preconj |
both,mock |
R106 |
T350 |
T337 |
amod |
mock,treated |
R107 |
T351 |
T350 |
punct |
-,mock |
R108 |
T352 |
T350 |
cc |
or,mock |
R109 |
T353 |
T350 |
conj |
cadmium,mock |
R110 |
T354 |
T337 |
punct |
-,treated |
R111 |
T355 |
T337 |
cc |
and,treated |
R112 |
T356 |
T357 |
npadvmod |
liver,specific |
R113 |
T357 |
T359 |
amod |
specific,transcription |
R114 |
T358 |
T357 |
punct |
-,specific |
R115 |
T359 |
T360 |
nsubjpass |
transcription,analyzed |
R116 |
T360 |
T337 |
conj |
analyzed,treated |
R117 |
T361 |
T360 |
auxpass |
was,analyzed |
R118 |
T362 |
T360 |
punct |
.,analyzed |
R119 |
T364 |
T365 |
prep |
Besides,emerged |
R120 |
T366 |
T367 |
det |
the,genes |
R121 |
T367 |
T364 |
pobj |
genes,Besides |
R122 |
T368 |
T369 |
advmod |
well,characterized |
R123 |
T369 |
T367 |
amod |
characterized,genes |
R124 |
T370 |
T369 |
punct |
-,characterized |
R125 |
T371 |
T367 |
compound |
metallothionein,genes |
R126 |
T372 |
T365 |
punct |
", ",emerged |
R127 |
T373 |
T374 |
amod |
several,genes |
R129 |
T375 |
T374 |
amod |
new,genes |
R130 |
T376 |
T374 |
nmod |
MTF,genes |
R131 |
T377 |
T376 |
punct |
-,MTF |
R132 |
T378 |
T376 |
nummod |
1,MTF |
R133 |
T379 |
T374 |
compound |
target,genes |
R134 |
T380 |
T374 |
prep |
with,genes |
R135 |
T381 |
T382 |
compound |
MRE,motifs |
R136 |
T382 |
T380 |
pobj |
motifs,with |
R137 |
T383 |
T382 |
prep |
in,motifs |
R138 |
T384 |
T385 |
det |
the,region |
R139 |
T385 |
T383 |
pobj |
region,in |
R140 |
T386 |
T385 |
compound |
promoter,region |
R141 |
T387 |
T365 |
punct |
.,emerged |
R142 |
T389 |
T390 |
nsubjpass |
MTF,required |
R143 |
T391 |
T389 |
punct |
-,MTF |
R144 |
T392 |
T389 |
nummod |
1,MTF |
R145 |
T393 |
T390 |
auxpass |
is,required |
R146 |
T394 |
T390 |
prep |
for,required |
R147 |
T395 |
T396 |
det |
the,expression |
R148 |
T396 |
T394 |
pobj |
expression,for |
R149 |
T397 |
T396 |
amod |
basal,expression |
R150 |
T398 |
T396 |
prep |
of,expression |
R151 |
T399 |
T400 |
nmod |
selenoprotein,gene |
R152 |
T400 |
T398 |
pobj |
gene,of |
R153 |
T401 |
T400 |
nmod |
W,gene |
R154 |
T402 |
T400 |
punct |
", ",gene |
R155 |
T403 |
T400 |
nmod |
muscle,gene |
R156 |
T404 |
T400 |
nummod |
1,gene |
R157 |
T405 |
T400 |
punct |
(,gene |
R158 |
T406 |
T400 |
appos |
Sepw1,gene |
R159 |
T407 |
T400 |
punct |
),gene |
R160 |
T408 |
T409 |
dep |
that,encodes |
R161 |
T409 |
T400 |
relcl |
encodes,gene |
R162 |
T410 |
T411 |
det |
a,protein |
R163 |
T411 |
T409 |
dobj |
protein,encodes |
R164 |
T412 |
T413 |
npadvmod |
glutathione,binding |
R165 |
T413 |
T411 |
amod |
binding,protein |
R166 |
T414 |
T413 |
punct |
-,binding |
R167 |
T415 |
T413 |
cc |
and,binding |
R168 |
T416 |
T417 |
amod |
putative,antioxidant |
R169 |
T417 |
T413 |
conj |
antioxidant,binding |
R170 |
T418 |
T409 |
punct |
", ",encodes |
R171 |
T419 |
T409 |
advcl |
supporting,encodes |
R172 |
T420 |
T421 |
det |
a,role |
R173 |
T421 |
T419 |
dobj |
role,supporting |
R174 |
T422 |
T421 |
prep |
of,role |
R175 |
T423 |
T422 |
pobj |
MTF,of |
R176 |
T424 |
T423 |
punct |
-,MTF |
R177 |
T425 |
T423 |
nummod |
1,MTF |
R178 |
T426 |
T421 |
prep |
in,role |
R179 |
T427 |
T428 |
det |
the,response |
R180 |
T428 |
T426 |
pobj |
response,in |
R181 |
T429 |
T428 |
amod |
oxidative,response |
R182 |
T430 |
T428 |
compound |
stress,response |
R183 |
T431 |
T390 |
punct |
.,required |
R184 |
T433 |
T434 |
advmod |
Furthermore,mediates |
R185 |
T435 |
T434 |
punct |
", ",mediates |
R186 |
T436 |
T434 |
nsubj |
MTF,mediates |
R187 |
T437 |
T436 |
punct |
-,MTF |
R188 |
T438 |
T436 |
nummod |
1,MTF |
R189 |
T439 |
T440 |
det |
the,expression |
R190 |
T440 |
T434 |
dobj |
expression,mediates |
R191 |
T441 |
T442 |
npadvmod |
cadmium,induced |
R192 |
T442 |
T440 |
amod |
induced,expression |
R193 |
T443 |
T442 |
punct |
-,induced |
R194 |
T444 |
T440 |
prep |
of,expression |
R195 |
T445 |
T446 |
nmod |
N,myc |
R196 |
T446 |
T448 |
nmod |
myc,gene |
R197 |
T447 |
T446 |
punct |
-,myc |
R198 |
T448 |
T444 |
pobj |
gene,of |
R199 |
T449 |
T450 |
advmod |
downstream,regulated |
R200 |
T450 |
T448 |
amod |
regulated,gene |
R201 |
T451 |
T448 |
nummod |
1,gene |
R202 |
T452 |
T448 |
punct |
(,gene |
R203 |
T453 |
T448 |
appos |
Ndrg1,gene |
R204 |
T454 |
T448 |
punct |
),gene |
R205 |
T455 |
T448 |
punct |
", ",gene |
R206 |
T456 |
T457 |
dep |
which,induced |
R207 |
T457 |
T448 |
relcl |
induced,gene |
R208 |
T458 |
T457 |
auxpass |
is,induced |
R209 |
T459 |
T457 |
agent |
by,induced |
R210 |
T460 |
T461 |
amod |
several,conditions |
R211 |
T461 |
T459 |
pobj |
conditions,by |
R212 |
T462 |
T461 |
compound |
stress,conditions |
R213 |
T463 |
T457 |
cc |
and,induced |
R214 |
T464 |
T465 |
auxpass |
is,overexpressed |
R215 |
T465 |
T457 |
conj |
overexpressed,induced |
R216 |
T466 |
T465 |
prep |
in,overexpressed |
R217 |
T467 |
T468 |
amod |
many,cancers |
R218 |
T468 |
T466 |
pobj |
cancers,in |
R219 |
T469 |
T434 |
punct |
.,mediates |
R220 |
T471 |
T472 |
nsubjpass |
MTF,involved |
R221 |
T473 |
T471 |
punct |
-,MTF |
R222 |
T474 |
T471 |
nummod |
1,MTF |
R223 |
T475 |
T472 |
auxpass |
is,involved |
R224 |
T476 |
T472 |
advmod |
also,involved |
R225 |
T477 |
T472 |
prep |
in,involved |
R226 |
T478 |
T479 |
det |
the,response |
R227 |
T479 |
T477 |
pobj |
response,in |
R228 |
T480 |
T479 |
compound |
cadmium,response |
R229 |
T481 |
T479 |
prep |
of,response |
R230 |
T482 |
T483 |
npadvmod |
cysteine,rich |
R231 |
T483 |
T488 |
amod |
rich,gene |
R232 |
T484 |
T482 |
punct |
-,cysteine |
R233 |
T485 |
T482 |
cc |
and,cysteine |
R234 |
T486 |
T482 |
conj |
glycine,cysteine |
R235 |
T487 |
T483 |
punct |
-,rich |
R236 |
T488 |
T481 |
pobj |
gene,of |
R237 |
T489 |
T488 |
nmod |
protein,gene |
R238 |
T490 |
T489 |
nummod |
1,protein |
R239 |
T491 |
T488 |
punct |
(,gene |
R240 |
T492 |
T488 |
appos |
Csrp1,gene |
R241 |
T493 |
T488 |
punct |
),gene |
R242 |
T494 |
T488 |
punct |
", ",gene |
R243 |
T495 |
T496 |
dep |
which,implicated |
R244 |
T496 |
T488 |
relcl |
implicated,gene |
R245 |
T497 |
T496 |
auxpass |
is,implicated |
R246 |
T498 |
T496 |
prep |
in,implicated |
R247 |
T499 |
T500 |
amod |
cytoskeletal,organization |
R248 |
T500 |
T498 |
pobj |
organization,in |
R249 |
T501 |
T472 |
punct |
.,involved |
R250 |
T503 |
T504 |
prep |
In,represses |
R251 |
T505 |
T503 |
pobj |
contrast,In |
R252 |
T506 |
T504 |
punct |
", ",represses |
R253 |
T507 |
T504 |
nsubj |
MTF,represses |
R254 |
T508 |
T507 |
punct |
-,MTF |
R255 |
T509 |
T507 |
nummod |
1,MTF |
R256 |
T510 |
T511 |
det |
the,expression |
R257 |
T511 |
T504 |
dobj |
expression,represses |
R258 |
T512 |
T511 |
amod |
basal,expression |
R259 |
T513 |
T511 |
prep |
of,expression |
R260 |
T514 |
T513 |
pobj |
Slc39a10,of |
R261 |
T515 |
T514 |
punct |
", ",Slc39a10 |
R262 |
T516 |
T517 |
det |
a,transporter |
R263 |
T517 |
T514 |
appos |
transporter,Slc39a10 |
R264 |
T518 |
T517 |
amod |
putative,transporter |
R265 |
T519 |
T517 |
compound |
zinc,transporter |
R266 |
T520 |
T504 |
punct |
.,represses |
R267 |
T522 |
T523 |
prep |
In,induced |
R268 |
T524 |
T525 |
det |
a,pathway |
R269 |
T525 |
T522 |
pobj |
pathway,In |
R270 |
T526 |
T525 |
amod |
independent,pathway |
R271 |
T527 |
T526 |
prep |
of,independent |
R272 |
T528 |
T527 |
pobj |
MTF,of |
R273 |
T529 |
T528 |
punct |
-,MTF |
R274 |
T530 |
T528 |
nummod |
1,MTF |
R275 |
T531 |
T523 |
punct |
", ",induced |
R276 |
T532 |
T523 |
nsubj |
cadmium,induced |
R277 |
T533 |
T523 |
advmod |
also,induced |
R278 |
T534 |
T535 |
det |
the,transcription |
R279 |
T535 |
T523 |
dobj |
transcription,induced |
R280 |
T536 |
T535 |
prep |
of,transcription |
R281 |
T537 |
T536 |
pobj |
genes,of |
R282 |
T538 |
T537 |
acl |
involved,genes |
R283 |
T539 |
T538 |
prep |
in,involved |
R284 |
T540 |
T541 |
det |
the,synthesis |
R285 |
T541 |
T539 |
pobj |
synthesis,in |
R286 |
T542 |
T541 |
cc |
and,synthesis |
R287 |
T543 |
T541 |
conj |
regeneration,synthesis |
R288 |
T544 |
T541 |
prep |
of,synthesis |
R289 |
T545 |
T544 |
pobj |
glutathione,of |
R290 |
T546 |
T545 |
punct |
", ",glutathione |
R291 |
T547 |
T548 |
det |
a,antioxidant |
R292 |
T548 |
T545 |
appos |
antioxidant,glutathione |
R293 |
T549 |
T550 |
npadvmod |
cadmium,binding |
R294 |
T550 |
T548 |
amod |
binding,antioxidant |
R295 |
T551 |
T550 |
punct |
-,binding |
R296 |
T552 |
T523 |
punct |
.,induced |
R297 |
T554 |
T555 |
det |
These,data |
R298 |
T555 |
T556 |
nsubj |
data,provide |
R299 |
T557 |
T558 |
amod |
strong,evidence |
R300 |
T558 |
T556 |
dobj |
evidence,provide |
R301 |
T559 |
T558 |
prep |
for,evidence |
R302 |
T560 |
T561 |
nummod |
two,branches |
R303 |
T561 |
T559 |
pobj |
branches,for |
R304 |
T562 |
T561 |
amod |
major,branches |
R305 |
T563 |
T561 |
prep |
of,branches |
R306 |
T564 |
T565 |
amod |
cellular,defense |
R307 |
T565 |
T563 |
pobj |
defense,of |
R308 |
T566 |
T565 |
amod |
anti-cadmium,defense |
R309 |
T567 |
T561 |
punct |
", ",branches |
R310 |
T568 |
T561 |
appos |
one,branches |
R311 |
T569 |
T568 |
prep |
via,one |
R312 |
T570 |
T569 |
pobj |
MTF,via |
R313 |
T571 |
T570 |
punct |
-,MTF |
R314 |
T572 |
T570 |
nummod |
1,MTF |
R315 |
T573 |
T570 |
cc |
and,MTF |
R316 |
T574 |
T575 |
poss |
its,genes |
R317 |
T575 |
T570 |
conj |
genes,MTF |
R318 |
T576 |
T575 |
compound |
target,genes |
R319 |
T577 |
T575 |
punct |
", ",genes |
R320 |
T578 |
T579 |
advmod |
notably,metallothioneins |
R321 |
T579 |
T575 |
appos |
metallothioneins,genes |
R322 |
T580 |
T568 |
punct |
", ",one |
R323 |
T581 |
T582 |
det |
the,other |
R324 |
T582 |
T568 |
appos |
other,one |
R325 |
T583 |
T582 |
prep |
via,other |
R326 |
T584 |
T583 |
pobj |
glutathione,via |
R327 |
T585 |
T582 |
punct |
", ",other |
R328 |
T586 |
T582 |
prep |
with,other |
R329 |
T587 |
T588 |
det |
an,overlap |
R330 |
T588 |
T586 |
pobj |
overlap,with |
R331 |
T589 |
T588 |
amod |
apparent,overlap |
R332 |
T590 |
T588 |
prep |
in,overlap |
R333 |
T591 |
T592 |
compound |
selenoprotein,W |
R334 |
T592 |
T590 |
pobj |
W,in |
R335 |
T593 |
T556 |
punct |
.,provide |
R128 |
T374 |
T365 |
nsubj |
genes,emerged |