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PMC:1253828 / 106-1838 JSONTXT

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Id Subject Object Predicate Lexical cue
T258 0-247 sentence denotes Metal-responsive transcription factor 1 (MTF-1) regulates expression of its target genes in response to various stress conditions, notably heavy metal load, via binding to metal response elements (MREs) in the respective enhancer/promoter regions.
T259 0-5 NN denotes Metal
T260 6-16 JJ denotes responsive
T261 5-6 HYPH denotes -
T262 31-37 NN denotes factor
T263 17-30 NN denotes transcription
T264 48-57 VBZ denotes regulates
T265 38-39 CD denotes 1
T266 40-41 -LRB- denotes (
T267 41-44 NN denotes MTF
T268 44-45 HYPH denotes -
T269 45-46 CD denotes 1
T270 46-47 -RRB- denotes )
T271 58-68 NN denotes expression
T272 69-71 IN denotes of
T273 72-75 PRP$ denotes its
T274 83-88 NNS denotes genes
T275 76-82 NN denotes target
T276 89-91 IN denotes in
T277 92-100 NN denotes response
T278 101-103 IN denotes to
T279 104-111 JJ denotes various
T280 119-129 NNS denotes conditions
T281 112-118 NN denotes stress
T282 129-131 , denotes ,
T283 131-138 RB denotes notably
T284 151-155 NN denotes load
T285 139-144 JJ denotes heavy
T286 145-150 NN denotes metal
T287 155-157 , denotes ,
T288 157-160 IN denotes via
T289 161-168 NN denotes binding
T290 169-171 IN denotes to
T291 172-177 NN denotes metal
T292 187-195 NNS denotes elements
T293 178-186 NN denotes response
T294 196-197 -LRB- denotes (
T295 197-201 NNS denotes MREs
T296 201-202 -RRB- denotes )
T297 203-205 IN denotes in
T298 206-209 DT denotes the
T299 239-246 NNS denotes regions
T300 210-220 JJ denotes respective
T301 221-229 NN denotes enhancer
T302 230-238 NN denotes promoter
T303 229-230 HYPH denotes /
T304 246-247 . denotes .
T305 247-319 sentence denotes Furthermore, it serves a vital function in embryonic liver development.
T306 248-259 RB denotes Furthermore
T307 264-270 VBZ denotes serves
T308 259-261 , denotes ,
T309 261-263 PRP denotes it
T310 271-272 DT denotes a
T311 279-287 NN denotes function
T312 273-278 JJ denotes vital
T313 288-290 IN denotes in
T314 291-300 JJ denotes embryonic
T315 307-318 NN denotes development
T316 301-306 NN denotes liver
T317 318-319 . denotes .
T318 319-400 sentence denotes However, targeted deletion of Mtf1 in the liver after birth is no longer lethal.
T319 320-327 RB denotes However
T320 380-382 VBZ denotes is
T321 327-329 , denotes ,
T322 329-337 VBN denotes targeted
T323 338-346 NN denotes deletion
T324 347-349 IN denotes of
T325 350-354 NN denotes Mtf1
T326 355-357 IN denotes in
T327 358-361 DT denotes the
T328 362-367 NN denotes liver
T329 368-373 IN denotes after
T330 374-379 NN denotes birth
T331 383-385 RB denotes no
T332 386-392 RB denotes longer
T333 393-399 JJ denotes lethal
T334 399-400 . denotes .
T335 400-553 sentence denotes For this study, Mtf1 conditional knockout mice and control littermates were both mock- or cadmium-treated and liver-specific transcription was analyzed.
T336 401-404 IN denotes For
T337 499-506 VBN denotes treated
T338 405-409 DT denotes this
T339 410-415 NN denotes study
T340 415-417 , denotes ,
T341 417-421 NN denotes Mtf1
T342 443-447 NNS denotes mice
T343 422-433 JJ denotes conditional
T344 434-442 NN denotes knockout
T345 448-451 CC denotes and
T346 452-459 NN denotes control
T347 460-471 NNS denotes littermates
T348 472-476 VBD denotes were
T349 477-481 CC denotes both
T350 482-486 JJ denotes mock
T351 486-487 HYPH denotes -
T352 488-490 CC denotes or
T353 491-498 NN denotes cadmium
T354 498-499 HYPH denotes -
T355 507-510 CC denotes and
T356 511-516 NN denotes liver
T357 517-525 JJ denotes specific
T358 516-517 HYPH denotes -
T359 526-539 NN denotes transcription
T360 544-552 VBN denotes analyzed
T361 540-543 VBD denotes was
T362 552-553 . denotes .
T363 553-686 sentence denotes Besides the well-characterized metallothionein genes, several new MTF-1 target genes with MRE motifs in the promoter region emerged.
T364 554-561 IN denotes Besides
T366 562-565 DT denotes the
T367 601-606 NNS denotes genes
T368 566-570 RB denotes well
T369 571-584 VBN denotes characterized
T370 570-571 HYPH denotes -
T371 585-600 NN denotes metallothionein
T372 606-608 , denotes ,
T373 608-615 JJ denotes several
T374 633-638 NNS denotes genes
T375 616-619 JJ denotes new
T376 620-623 NN denotes MTF
T377 623-624 HYPH denotes -
T378 624-625 CD denotes 1
T379 626-632 NN denotes target
T380 639-643 IN denotes with
T381 644-647 NN denotes MRE
T382 648-654 NNS denotes motifs
T383 655-657 IN denotes in
T384 658-661 DT denotes the
T385 671-677 NN denotes region
T386 662-670 NN denotes promoter
T387 685-686 . denotes .
T388 686-901 sentence denotes MTF-1 is required for the basal expression of selenoprotein W, muscle 1 gene (Sepw1) that encodes a glutathione-binding and putative antioxidant protein, supporting a role of MTF-1 in the oxidative stress response.
T389 687-690 NN denotes MTF
T390 696-704 VBN denotes required
T391 690-691 HYPH denotes -
T392 691-692 CD denotes 1
T393 693-695 VBZ denotes is
T394 705-708 IN denotes for
T395 709-712 DT denotes the
T396 719-729 NN denotes expression
T397 713-718 JJ denotes basal
T398 730-732 IN denotes of
T399 733-746 NN denotes selenoprotein
T400 759-763 NN denotes gene
T401 747-748 NN denotes W
T402 748-750 , denotes ,
T403 750-756 NN denotes muscle
T404 757-758 CD denotes 1
T405 764-765 -LRB- denotes (
T406 765-770 NN denotes Sepw1
T407 770-771 -RRB- denotes )
T408 772-776 WDT denotes that
T409 777-784 VBZ denotes encodes
T410 785-786 DT denotes a
T411 832-839 NN denotes protein
T412 787-798 NN denotes glutathione
T413 799-806 VBG denotes binding
T414 798-799 HYPH denotes -
T415 807-810 CC denotes and
T416 811-819 JJ denotes putative
T417 820-831 NN denotes antioxidant
T418 839-841 , denotes ,
T419 841-851 VBG denotes supporting
T420 852-853 DT denotes a
T421 854-858 NN denotes role
T422 859-861 IN denotes of
T423 862-865 NN denotes MTF
T424 865-866 HYPH denotes -
T425 866-867 CD denotes 1
T426 868-870 IN denotes in
T427 871-874 DT denotes the
T428 892-900 NN denotes response
T429 875-884 JJ denotes oxidative
T430 885-891 NN denotes stress
T431 900-901 . denotes .
T432 901-1090 sentence denotes Furthermore, MTF-1 mediates the cadmium-induced expression of N-myc downstream regulated gene 1 (Ndrg1), which is induced by several stress conditions and is overexpressed in many cancers.
T433 902-913 RB denotes Furthermore
T434 921-929 VBZ denotes mediates
T435 913-915 , denotes ,
T436 915-918 NN denotes MTF
T437 918-919 HYPH denotes -
T438 919-920 CD denotes 1
T439 930-933 DT denotes the
T440 950-960 NN denotes expression
T441 934-941 NN denotes cadmium
T442 942-949 VBN denotes induced
T443 941-942 HYPH denotes -
T444 961-963 IN denotes of
T445 964-965 NN denotes N
T446 966-969 NN denotes myc
T447 965-966 HYPH denotes -
T448 991-995 NN denotes gene
T449 970-980 RB denotes downstream
T450 981-990 VBN denotes regulated
T451 996-997 CD denotes 1
T452 998-999 -LRB- denotes (
T453 999-1004 NN denotes Ndrg1
T454 1004-1005 -RRB- denotes )
T455 1005-1007 , denotes ,
T456 1007-1012 WDT denotes which
T457 1016-1023 VBN denotes induced
T458 1013-1015 VBZ denotes is
T459 1024-1026 IN denotes by
T460 1027-1034 JJ denotes several
T461 1042-1052 NNS denotes conditions
T462 1035-1041 NN denotes stress
T463 1053-1056 CC denotes and
T464 1057-1059 VBZ denotes is
T465 1060-1073 VBN denotes overexpressed
T466 1074-1076 IN denotes in
T467 1077-1081 JJ denotes many
T468 1082-1089 NNS denotes cancers
T469 1089-1090 . denotes .
T470 1090-1241 sentence denotes MTF-1 is also involved in the cadmium response of cysteine- and glycine-rich protein 1 gene (Csrp1), which is implicated in cytoskeletal organization.
T471 1091-1094 NN denotes MTF
T472 1105-1113 VBN denotes involved
T473 1094-1095 HYPH denotes -
T474 1095-1096 CD denotes 1
T475 1097-1099 VBZ denotes is
T476 1100-1104 RB denotes also
T477 1114-1116 IN denotes in
T478 1117-1120 DT denotes the
T479 1129-1137 NN denotes response
T480 1121-1128 NN denotes cadmium
T481 1138-1140 IN denotes of
T482 1141-1149 NN denotes cysteine
T483 1163-1167 JJ denotes rich
T484 1149-1150 HYPH denotes -
T485 1151-1154 CC denotes and
T486 1155-1162 NN denotes glycine
T487 1162-1163 HYPH denotes -
T488 1178-1182 NN denotes gene
T489 1168-1175 NN denotes protein
T490 1176-1177 CD denotes 1
T491 1183-1184 -LRB- denotes (
T492 1184-1189 NN denotes Csrp1
T493 1189-1190 -RRB- denotes )
T494 1190-1192 , denotes ,
T495 1192-1197 WDT denotes which
T496 1201-1211 VBN denotes implicated
T497 1198-1200 VBZ denotes is
T498 1212-1214 IN denotes in
T499 1215-1227 JJ denotes cytoskeletal
T500 1228-1240 NN denotes organization
T501 1240-1241 . denotes .
T502 1241-1333 sentence denotes In contrast, MTF-1 represses the basal expression of Slc39a10, a putative zinc transporter.
T503 1242-1244 IN denotes In
T504 1261-1270 VBZ denotes represses
T505 1245-1253 NN denotes contrast
T506 1253-1255 , denotes ,
T507 1255-1258 NN denotes MTF
T508 1258-1259 HYPH denotes -
T509 1259-1260 CD denotes 1
T510 1271-1274 DT denotes the
T511 1281-1291 NN denotes expression
T512 1275-1280 JJ denotes basal
T513 1292-1294 IN denotes of
T514 1295-1303 NN denotes Slc39a10
T515 1303-1305 , denotes ,
T516 1305-1306 DT denotes a
T517 1321-1332 NN denotes transporter
T518 1307-1315 JJ denotes putative
T519 1316-1320 NN denotes zinc
T520 1332-1333 . denotes .
T521 1333-1506 sentence denotes In a pathway independent of MTF-1, cadmium also induced the transcription of genes involved in the synthesis and regeneration of glutathione, a cadmium-binding antioxidant.
T522 1334-1336 IN denotes In
T523 1382-1389 VBD denotes induced
T524 1337-1338 DT denotes a
T525 1339-1346 NN denotes pathway
T526 1347-1358 JJ denotes independent
T527 1359-1361 IN denotes of
T528 1362-1365 NN denotes MTF
T529 1365-1366 HYPH denotes -
T530 1366-1367 CD denotes 1
T531 1367-1369 , denotes ,
T532 1369-1376 NN denotes cadmium
T533 1377-1381 RB denotes also
T534 1390-1393 DT denotes the
T535 1394-1407 NN denotes transcription
T536 1408-1410 IN denotes of
T537 1411-1416 NNS denotes genes
T538 1417-1425 VBN denotes involved
T539 1426-1428 IN denotes in
T540 1429-1432 DT denotes the
T541 1433-1442 NN denotes synthesis
T542 1443-1446 CC denotes and
T543 1447-1459 NN denotes regeneration
T544 1460-1462 IN denotes of
T545 1463-1474 NN denotes glutathione
T546 1474-1476 , denotes ,
T547 1476-1477 DT denotes a
T548 1494-1505 NN denotes antioxidant
T549 1478-1485 NN denotes cadmium
T550 1486-1493 VBG denotes binding
T551 1485-1486 HYPH denotes -
T552 1505-1506 . denotes .
T553 1506-1732 sentence denotes These data provide strong evidence for two major branches of cellular anti-cadmium defense, one via MTF-1 and its target genes, notably metallothioneins, the other via glutathione, with an apparent overlap in selenoprotein W.
T554 1507-1512 DT denotes These
T555 1513-1517 NNS denotes data
T556 1518-1525 VBP denotes provide
T557 1526-1532 JJ denotes strong
T558 1533-1541 NN denotes evidence
T559 1542-1545 IN denotes for
T560 1546-1549 CD denotes two
T561 1556-1564 NNS denotes branches
T562 1550-1555 JJ denotes major
T563 1565-1567 IN denotes of
T564 1568-1576 JJ denotes cellular
T565 1590-1597 NN denotes defense
T566 1577-1589 JJ denotes anti-cadmium
T567 1597-1599 , denotes ,
T568 1599-1602 CD denotes one
T569 1603-1606 IN denotes via
T570 1607-1610 NN denotes MTF
T571 1610-1611 HYPH denotes -
T572 1611-1612 CD denotes 1
T573 1613-1616 CC denotes and
T574 1617-1620 PRP$ denotes its
T575 1628-1633 NNS denotes genes
T576 1621-1627 NN denotes target
T577 1633-1635 , denotes ,
T578 1635-1642 RB denotes notably
T579 1643-1659 NNS denotes metallothioneins
T580 1659-1661 , denotes ,
T581 1661-1664 DT denotes the
T582 1665-1670 JJ denotes other
T583 1671-1674 IN denotes via
T584 1675-1686 NN denotes glutathione
T585 1686-1688 , denotes ,
T586 1688-1692 IN denotes with
T587 1693-1695 DT denotes an
T588 1705-1712 NN denotes overlap
T589 1696-1704 JJ denotes apparent
T590 1713-1715 IN denotes in
T591 1716-1729 NN denotes selenoprotein
T592 1730-1731 NN denotes W
T593 1731-1732 . denotes .
T365 678-685 VBD denotes emerged
R41 T279 T280 amod various,conditions
R42 T280 T278 pobj conditions,to
R22 T259 T260 npadvmod Metal,responsive
R23 T260 T262 amod responsive,factor
R24 T261 T260 punct -,responsive
R25 T262 T264 nsubj factor,regulates
R26 T263 T262 compound transcription,factor
R27 T265 T262 nummod 1,factor
R28 T266 T262 punct (,factor
R29 T267 T262 appos MTF,factor
R30 T268 T267 punct -,MTF
R31 T269 T267 nummod 1,MTF
R32 T270 T264 punct ),regulates
R33 T271 T264 dobj expression,regulates
R34 T272 T271 prep of,expression
R35 T273 T274 poss its,genes
R36 T274 T272 pobj genes,of
R37 T275 T274 compound target,genes
R38 T276 T264 prep in,regulates
R39 T277 T276 pobj response,in
R40 T278 T277 prep to,response
R43 T281 T280 compound stress,conditions
R44 T282 T280 punct ", ",conditions
R45 T283 T284 advmod notably,load
R46 T284 T280 appos load,conditions
R47 T285 T286 amod heavy,metal
R48 T286 T284 compound metal,load
R49 T287 T264 punct ", ",regulates
R50 T288 T264 prep via,regulates
R51 T289 T288 pobj binding,via
R52 T290 T289 prep to,binding
R53 T291 T292 compound metal,elements
R54 T292 T290 pobj elements,to
R55 T293 T292 compound response,elements
R56 T294 T292 punct (,elements
R57 T295 T292 appos MREs,elements
R58 T296 T289 punct ),binding
R59 T297 T289 prep in,binding
R60 T298 T299 det the,regions
R61 T299 T297 pobj regions,in
R62 T300 T299 amod respective,regions
R63 T301 T302 compound enhancer,promoter
R64 T302 T299 compound promoter,regions
R65 T303 T302 punct /,promoter
R66 T304 T264 punct .,regulates
R67 T306 T307 advmod Furthermore,serves
R68 T308 T307 punct ", ",serves
R69 T309 T307 nsubj it,serves
R70 T310 T311 det a,function
R71 T311 T307 dobj function,serves
R72 T312 T311 amod vital,function
R73 T313 T307 prep in,serves
R74 T314 T315 amod embryonic,development
R75 T315 T313 pobj development,in
R76 T316 T315 compound liver,development
R77 T317 T307 punct .,serves
R78 T319 T320 advmod However,is
R79 T321 T320 punct ", ",is
R80 T322 T323 amod targeted,deletion
R81 T323 T320 nsubj deletion,is
R82 T324 T323 prep of,deletion
R83 T325 T324 pobj Mtf1,of
R84 T326 T323 prep in,deletion
R85 T327 T328 det the,liver
R86 T328 T326 pobj liver,in
R87 T329 T323 prep after,deletion
R88 T330 T329 pobj birth,after
R89 T331 T332 neg no,longer
R90 T332 T320 advmod longer,is
R91 T333 T320 acomp lethal,is
R92 T334 T320 punct .,is
R93 T336 T337 prep For,treated
R94 T338 T339 det this,study
R95 T339 T336 pobj study,For
R96 T340 T337 punct ", ",treated
R97 T341 T342 nmod Mtf1,mice
R98 T342 T337 nsubjpass mice,treated
R99 T343 T344 amod conditional,knockout
R100 T344 T342 compound knockout,mice
R101 T345 T342 cc and,mice
R102 T346 T347 compound control,littermates
R103 T347 T342 conj littermates,mice
R104 T348 T337 auxpass were,treated
R105 T349 T350 preconj both,mock
R106 T350 T337 amod mock,treated
R107 T351 T350 punct -,mock
R108 T352 T350 cc or,mock
R109 T353 T350 conj cadmium,mock
R110 T354 T337 punct -,treated
R111 T355 T337 cc and,treated
R112 T356 T357 npadvmod liver,specific
R113 T357 T359 amod specific,transcription
R114 T358 T357 punct -,specific
R115 T359 T360 nsubjpass transcription,analyzed
R116 T360 T337 conj analyzed,treated
R117 T361 T360 auxpass was,analyzed
R118 T362 T360 punct .,analyzed
R119 T364 T365 prep Besides,emerged
R120 T366 T367 det the,genes
R121 T367 T364 pobj genes,Besides
R122 T368 T369 advmod well,characterized
R123 T369 T367 amod characterized,genes
R124 T370 T369 punct -,characterized
R125 T371 T367 compound metallothionein,genes
R126 T372 T365 punct ", ",emerged
R127 T373 T374 amod several,genes
R129 T375 T374 amod new,genes
R130 T376 T374 nmod MTF,genes
R131 T377 T376 punct -,MTF
R132 T378 T376 nummod 1,MTF
R133 T379 T374 compound target,genes
R134 T380 T374 prep with,genes
R135 T381 T382 compound MRE,motifs
R136 T382 T380 pobj motifs,with
R137 T383 T382 prep in,motifs
R138 T384 T385 det the,region
R139 T385 T383 pobj region,in
R140 T386 T385 compound promoter,region
R141 T387 T365 punct .,emerged
R142 T389 T390 nsubjpass MTF,required
R143 T391 T389 punct -,MTF
R144 T392 T389 nummod 1,MTF
R145 T393 T390 auxpass is,required
R146 T394 T390 prep for,required
R147 T395 T396 det the,expression
R148 T396 T394 pobj expression,for
R149 T397 T396 amod basal,expression
R150 T398 T396 prep of,expression
R151 T399 T400 nmod selenoprotein,gene
R152 T400 T398 pobj gene,of
R153 T401 T400 nmod W,gene
R154 T402 T400 punct ", ",gene
R155 T403 T400 nmod muscle,gene
R156 T404 T400 nummod 1,gene
R157 T405 T400 punct (,gene
R158 T406 T400 appos Sepw1,gene
R159 T407 T400 punct ),gene
R160 T408 T409 dep that,encodes
R161 T409 T400 relcl encodes,gene
R162 T410 T411 det a,protein
R163 T411 T409 dobj protein,encodes
R164 T412 T413 npadvmod glutathione,binding
R165 T413 T411 amod binding,protein
R166 T414 T413 punct -,binding
R167 T415 T413 cc and,binding
R168 T416 T417 amod putative,antioxidant
R169 T417 T413 conj antioxidant,binding
R170 T418 T409 punct ", ",encodes
R171 T419 T409 advcl supporting,encodes
R172 T420 T421 det a,role
R173 T421 T419 dobj role,supporting
R174 T422 T421 prep of,role
R175 T423 T422 pobj MTF,of
R176 T424 T423 punct -,MTF
R177 T425 T423 nummod 1,MTF
R178 T426 T421 prep in,role
R179 T427 T428 det the,response
R180 T428 T426 pobj response,in
R181 T429 T428 amod oxidative,response
R182 T430 T428 compound stress,response
R183 T431 T390 punct .,required
R184 T433 T434 advmod Furthermore,mediates
R185 T435 T434 punct ", ",mediates
R186 T436 T434 nsubj MTF,mediates
R187 T437 T436 punct -,MTF
R188 T438 T436 nummod 1,MTF
R189 T439 T440 det the,expression
R190 T440 T434 dobj expression,mediates
R191 T441 T442 npadvmod cadmium,induced
R192 T442 T440 amod induced,expression
R193 T443 T442 punct -,induced
R194 T444 T440 prep of,expression
R195 T445 T446 nmod N,myc
R196 T446 T448 nmod myc,gene
R197 T447 T446 punct -,myc
R198 T448 T444 pobj gene,of
R199 T449 T450 advmod downstream,regulated
R200 T450 T448 amod regulated,gene
R201 T451 T448 nummod 1,gene
R202 T452 T448 punct (,gene
R203 T453 T448 appos Ndrg1,gene
R204 T454 T448 punct ),gene
R205 T455 T448 punct ", ",gene
R206 T456 T457 dep which,induced
R207 T457 T448 relcl induced,gene
R208 T458 T457 auxpass is,induced
R209 T459 T457 agent by,induced
R210 T460 T461 amod several,conditions
R211 T461 T459 pobj conditions,by
R212 T462 T461 compound stress,conditions
R213 T463 T457 cc and,induced
R214 T464 T465 auxpass is,overexpressed
R215 T465 T457 conj overexpressed,induced
R216 T466 T465 prep in,overexpressed
R217 T467 T468 amod many,cancers
R218 T468 T466 pobj cancers,in
R219 T469 T434 punct .,mediates
R220 T471 T472 nsubjpass MTF,involved
R221 T473 T471 punct -,MTF
R222 T474 T471 nummod 1,MTF
R223 T475 T472 auxpass is,involved
R224 T476 T472 advmod also,involved
R225 T477 T472 prep in,involved
R226 T478 T479 det the,response
R227 T479 T477 pobj response,in
R228 T480 T479 compound cadmium,response
R229 T481 T479 prep of,response
R230 T482 T483 npadvmod cysteine,rich
R231 T483 T488 amod rich,gene
R232 T484 T482 punct -,cysteine
R233 T485 T482 cc and,cysteine
R234 T486 T482 conj glycine,cysteine
R235 T487 T483 punct -,rich
R236 T488 T481 pobj gene,of
R237 T489 T488 nmod protein,gene
R238 T490 T489 nummod 1,protein
R239 T491 T488 punct (,gene
R240 T492 T488 appos Csrp1,gene
R241 T493 T488 punct ),gene
R242 T494 T488 punct ", ",gene
R243 T495 T496 dep which,implicated
R244 T496 T488 relcl implicated,gene
R245 T497 T496 auxpass is,implicated
R246 T498 T496 prep in,implicated
R247 T499 T500 amod cytoskeletal,organization
R248 T500 T498 pobj organization,in
R249 T501 T472 punct .,involved
R250 T503 T504 prep In,represses
R251 T505 T503 pobj contrast,In
R252 T506 T504 punct ", ",represses
R253 T507 T504 nsubj MTF,represses
R254 T508 T507 punct -,MTF
R255 T509 T507 nummod 1,MTF
R256 T510 T511 det the,expression
R257 T511 T504 dobj expression,represses
R258 T512 T511 amod basal,expression
R259 T513 T511 prep of,expression
R260 T514 T513 pobj Slc39a10,of
R261 T515 T514 punct ", ",Slc39a10
R262 T516 T517 det a,transporter
R263 T517 T514 appos transporter,Slc39a10
R264 T518 T517 amod putative,transporter
R265 T519 T517 compound zinc,transporter
R266 T520 T504 punct .,represses
R267 T522 T523 prep In,induced
R268 T524 T525 det a,pathway
R269 T525 T522 pobj pathway,In
R270 T526 T525 amod independent,pathway
R271 T527 T526 prep of,independent
R272 T528 T527 pobj MTF,of
R273 T529 T528 punct -,MTF
R274 T530 T528 nummod 1,MTF
R275 T531 T523 punct ", ",induced
R276 T532 T523 nsubj cadmium,induced
R277 T533 T523 advmod also,induced
R278 T534 T535 det the,transcription
R279 T535 T523 dobj transcription,induced
R280 T536 T535 prep of,transcription
R281 T537 T536 pobj genes,of
R282 T538 T537 acl involved,genes
R283 T539 T538 prep in,involved
R284 T540 T541 det the,synthesis
R285 T541 T539 pobj synthesis,in
R286 T542 T541 cc and,synthesis
R287 T543 T541 conj regeneration,synthesis
R288 T544 T541 prep of,synthesis
R289 T545 T544 pobj glutathione,of
R290 T546 T545 punct ", ",glutathione
R291 T547 T548 det a,antioxidant
R292 T548 T545 appos antioxidant,glutathione
R293 T549 T550 npadvmod cadmium,binding
R294 T550 T548 amod binding,antioxidant
R295 T551 T550 punct -,binding
R296 T552 T523 punct .,induced
R297 T554 T555 det These,data
R298 T555 T556 nsubj data,provide
R299 T557 T558 amod strong,evidence
R300 T558 T556 dobj evidence,provide
R301 T559 T558 prep for,evidence
R302 T560 T561 nummod two,branches
R303 T561 T559 pobj branches,for
R304 T562 T561 amod major,branches
R305 T563 T561 prep of,branches
R306 T564 T565 amod cellular,defense
R307 T565 T563 pobj defense,of
R308 T566 T565 amod anti-cadmium,defense
R309 T567 T561 punct ", ",branches
R310 T568 T561 appos one,branches
R311 T569 T568 prep via,one
R312 T570 T569 pobj MTF,via
R313 T571 T570 punct -,MTF
R314 T572 T570 nummod 1,MTF
R315 T573 T570 cc and,MTF
R316 T574 T575 poss its,genes
R317 T575 T570 conj genes,MTF
R318 T576 T575 compound target,genes
R319 T577 T575 punct ", ",genes
R320 T578 T579 advmod notably,metallothioneins
R321 T579 T575 appos metallothioneins,genes
R322 T580 T568 punct ", ",one
R323 T581 T582 det the,other
R324 T582 T568 appos other,one
R325 T583 T582 prep via,other
R326 T584 T583 pobj glutathione,via
R327 T585 T582 punct ", ",other
R328 T586 T582 prep with,other
R329 T587 T588 det an,overlap
R330 T588 T586 pobj overlap,with
R331 T589 T588 amod apparent,overlap
R332 T590 T588 prep in,overlap
R333 T591 T592 compound selenoprotein,W
R334 T592 T590 pobj W,in
R335 T593 T556 punct .,provide
R128 T374 T365 nsubj genes,emerged

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T84 0-39 PR:000010717 denotes Metal-responsive transcription factor 1
T85 41-46 PR:000010717 denotes MTF-1
T86 48-57 GO:0065007 denotes regulates
T87 58-68 GO:0010467 denotes expression
T88 83-88 SO:0000704 denotes genes
T89 221-229 SO:0000165 denotes enhancer
T90 230-238 SO:0000167 denotes promoter
T91 291-300 UBERON:0000922 denotes embryonic
T92 291-300 _FRAGMENT denotes embryonic
T93 307-318 GO:0009790 denotes development
T94 301-306 UBERON:0002107 denotes liver
T95 301-318 GO:0001889 denotes liver development
T96 350-354 PR:000010717 denotes Mtf1
T97 362-367 UBERON:0002107 denotes liver
T98 374-379 GO:0007567 denotes birth
T99 417-421 PR:000010717 denotes Mtf1
T100 443-447 NCBITaxon:10088 denotes mice
T101 511-516 UBERON:0002107 denotes liver
T102 601-606 SO:0000704 denotes genes
T103 620-625 PR:000010717 denotes MTF-1
T104 633-638 SO:0000704 denotes genes
T105 662-670 SO:0000167 denotes promoter
T106 687-692 PR:000010717 denotes MTF-1
T107 719-729 GO:0010467 denotes expression
T108 733-758 PR:000014662 denotes selenoprotein W, muscle 1
T109 759-763 SO:0000704 denotes gene
T110 765-770 PR:000014662 denotes Sepw1
T111 787-798 CHEBI:16856 denotes glutathione
T112 862-867 PR:000010717 denotes MTF-1
T113 875-884 MOP:0000568 denotes oxidative
T114 915-920 PR:000010717 denotes MTF-1
T115 950-960 GO:0010467 denotes expression
T116 964-997 PR:000011059 denotes N-myc downstream regulated gene 1
T117 981-990 GO:0065007 denotes regulated
T118 991-995 SO:0000704 denotes gene
T119 999-1004 PR:000011059 denotes Ndrg1
T120 1064-1073 GO:0010467 denotes expressed
T121 1091-1096 PR:000010717 denotes MTF-1
T122 1141-1177 PR:000005958 denotes cysteine- and glycine-rich protein 1
T123 1178-1182 SO:0000704 denotes gene
T124 1184-1189 PR:000005958 denotes Csrp1
T125 1215-1227 GO:0005856 denotes cytoskeletal
T126 1255-1260 PR:000010717 denotes MTF-1
T127 1281-1291 GO:0010467 denotes expression
T128 1295-1303 PR:000015124 denotes Slc39a10
T129 1362-1367 PR:000010717 denotes MTF-1
T130 1411-1416 SO:0000704 denotes genes
T131 1433-1442 _FRAGMENT denotes synthesis
T132 1460-1474 GO:0006750 denotes of glutathione
T133 1463-1474 CHEBI:16856 denotes glutathione
T134 1568-1576 _FRAGMENT denotes cellular
T135 1590-1597 GO:0006968 denotes defense
T136 1607-1612 PR:000010717 denotes MTF-1
T137 1628-1633 SO:0000704 denotes genes
T138 1675-1686 CHEBI:16856 denotes glutathione
T139 1716-1731 PR:000014662 denotes selenoprotein W
R1 T93 T92 _lexicallyChainedTo development,embryonic
R2 T132 T131 _lexicallyChainedTo of glutathione,synthesis
R3 T135 T134 _lexicallyChainedTo defense,cellular

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T145 0-5 CHEBI_EXT:metal denotes Metal
T146 0-39 PR_EXT:000010717 denotes Metal-responsive transcription factor 1
T147 17-30 GO_EXT:transcription denotes transcription
T148 17-37 GO_EXT:transcription_factor denotes transcription factor
T149 41-46 PR_EXT:000010717 denotes MTF-1
T150 48-57 GO:0065007 denotes regulates
T151 58-68 GO:0010467 denotes expression
T152 83-88 SO_EXT:0000704 denotes genes
T153 92-100 GO_EXT:reaction_or_response denotes response
T154 145-150 CHEBI_EXT:metal denotes metal
T155 161-168 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T156 172-177 CHEBI_EXT:metal denotes metal
T157 178-186 GO_EXT:reaction_or_response denotes response
T158 221-229 SO_EXT:0000165 denotes enhancer
T159 230-238 SO_EXT:0000167 denotes promoter
T160 291-300 UBERON:0000922 denotes embryonic
T161 291-300 _FRAGMENT denotes embryonic
T162 307-318 GO:0009790 denotes development
T163 301-306 UBERON:0002107 denotes liver
T164 301-318 GO:0001889 denotes liver development
T165 338-346 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T166 350-354 PR_EXT:000010717 denotes Mtf1
T167 362-367 UBERON:0002107 denotes liver
T168 374-379 GO:0007567 denotes birth
T169 393-399 GO_EXT:fatality_or_lethality denotes lethal
T170 417-421 PR_EXT:000010717 denotes Mtf1
T171 443-447 NCBITaxon:10088 denotes mice
T172 491-498 CHEBI_EXT:cadmium denotes cadmium
T173 511-516 UBERON:0002107 denotes liver
T174 526-539 GO_EXT:transcription denotes transcription
T175 601-606 SO_EXT:0000704 denotes genes
T176 620-625 PR_EXT:000010717 denotes MTF-1
T177 633-638 SO_EXT:0000704 denotes genes
T178 648-654 SO_EXT:sequence_or_structure_motif denotes motifs
T179 662-670 SO_EXT:0000167 denotes promoter
T180 687-692 PR_EXT:000010717 denotes MTF-1
T181 719-729 GO:0010467 denotes expression
T182 733-746 CHEBI_EXT:selenoprotein denotes selenoprotein
T183 733-758 PR_EXT:000014662 denotes selenoprotein W, muscle 1
T184 750-756 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T185 759-763 SO_EXT:0000704 denotes gene
T186 765-770 PR_EXT:000014662 denotes Sepw1
T187 777-784 SO_EXT:sequence_coding_function denotes encodes
T188 787-798 CHEBI:16856 denotes glutathione
T189 799-806 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T190 820-831 CHEBI_GO_EXT:antioxidant denotes antioxidant
T191 824-831 CHEBI_MOP_EXT:oxidising_agent_or_oxidation denotes oxidant
T192 832-839 CHEBI_PR_EXT:protein denotes protein
T193 862-867 PR_EXT:000010717 denotes MTF-1
T194 875-884 MOP:0000568 denotes oxidative
T195 892-900 GO_EXT:reaction_or_response denotes response
T196 915-920 PR_EXT:000010717 denotes MTF-1
T197 934-941 CHEBI_EXT:cadmium denotes cadmium
T198 950-960 GO:0010467 denotes expression
T199 964-997 PR_EXT:000011059 denotes N-myc downstream regulated gene 1
T200 981-990 GO:0065007 denotes regulated
T201 991-995 SO_EXT:0000704 denotes gene
T202 999-1004 PR_EXT:000011059 denotes Ndrg1
T203 1064-1073 GO:0010467 denotes expressed
T204 1091-1096 PR_EXT:000010717 denotes MTF-1
T205 1121-1128 CHEBI_EXT:cadmium denotes cadmium
T206 1129-1137 GO_EXT:reaction_or_response denotes response
T207 1141-1149 CHEBI_SO_EXT:cysteine denotes cysteine
T208 1141-1177 PR_EXT:000005958 denotes cysteine- and glycine-rich protein 1
T209 1155-1162 CHEBI_SO_EXT:glycine denotes glycine
T210 1168-1175 CHEBI_PR_EXT:protein denotes protein
T211 1178-1182 SO_EXT:0000704 denotes gene
T212 1184-1189 PR_EXT:000005958 denotes Csrp1
T213 1215-1227 GO:0005856 denotes cytoskeletal
T214 1255-1260 PR_EXT:000010717 denotes MTF-1
T215 1281-1291 GO:0010467 denotes expression
T216 1295-1303 PR_EXT:000015124 denotes Slc39a10
T217 1316-1320 CHEBI_EXT:zinc denotes zinc
T218 1321-1332 GO_EXT:biological_mover_or_transporter denotes transporter
T219 1362-1367 PR_EXT:000010717 denotes MTF-1
T220 1369-1376 CHEBI_EXT:cadmium denotes cadmium
T221 1394-1407 GO_EXT:transcription denotes transcription
T222 1411-1416 SO_EXT:0000704 denotes genes
T223 1433-1442 _FRAGMENT denotes synthesis
T224 1460-1474 GO:0006750 denotes of glutathione
T225 1463-1474 CHEBI:16856 denotes glutathione
T226 1478-1485 CHEBI_EXT:cadmium denotes cadmium
T227 1486-1493 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T228 1494-1505 CHEBI_GO_EXT:antioxidant denotes antioxidant
T229 1498-1505 CHEBI_MOP_EXT:oxidising_agent_or_oxidation denotes oxidant
T230 1568-1576 CL_GO_EXT:cell denotes cellular
T231 1568-1576 _FRAGMENT denotes cellular
T232 1590-1597 GO:0006968 denotes defense
T233 1582-1589 CHEBI_EXT:cadmium denotes cadmium
T234 1607-1612 PR_EXT:000010717 denotes MTF-1
T235 1628-1633 SO_EXT:0000704 denotes genes
T236 1675-1686 CHEBI:16856 denotes glutathione
T237 1716-1729 CHEBI_EXT:selenoprotein denotes selenoprotein
T238 1716-1731 PR_EXT:000014662 denotes selenoprotein W
R4 T162 T161 _lexicallyChainedTo development,embryonic
R5 T224 T223 _lexicallyChainedTo of glutathione,synthesis
R6 T232 T231 _lexicallyChainedTo defense,cellular