PMC:1247560 / 3979-4971 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1247560","sourcedb":"PMC","sourceid":"1247560","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1247560","text":"The high incidence of acute infectious diseases in infants and children from Nunavik has been known for many years (Bruneau et al. 2001; Dufour 1988; Proulx 1988; Thérien 1988). In this context, we hypothesized that the incidence of infections among Inuit infants was related in part to the high maternal body burden of immunotoxic food-chain contaminants during pregnancy. In 2000, we published a first study on susceptibility to infection in Inuit infants recruited between 1989 and 1990 (Dewailly et al. 2000). We found that the risk of acute otitis media and recurrent otitis media was positively associated with prenatal exposure to OCs. However, postnatal exposure was not considered, and some potential confounding factors could not be evaluated. To confirm the association observed, we investigated the association between exposure to OCs and the incidence rate of acute infections during the first year of life in a second cohort of 199 Inuit infants recruited between 1995 and 2001.","tracks":[]}