PMC:1208879 / 503-1127 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T268","span":{"begin":0,"end":7},"obj":"NNS"},{"id":"T269","span":{"begin":7,"end":123},"obj":"sentence"},{"id":"T270","span":{"begin":8,"end":10},"obj":"PRP"},{"id":"T271","span":{"begin":11,"end":15},"obj":"VBD"},{"id":"T272","span":{"begin":16,"end":30},"obj":"NN"},{"id":"T273","span":{"begin":31,"end":41},"obj":"NNS"},{"id":"T274","span":{"begin":42,"end":44},"obj":"TO"},{"id":"T275","span":{"begin":45,"end":57},"obj":"VB"},{"id":"T276","span":{"begin":58,"end":59},"obj":"DT"},{"id":"T277","span":{"begin":77,"end":84},"obj":"NN"},{"id":"T278","span":{"begin":60,"end":66},"obj":"RB"},{"id":"T279","span":{"begin":67,"end":76},"obj":"VBN"},{"id":"T280","span":{"begin":85,"end":87},"obj":"IN"},{"id":"T281","span":{"begin":88,"end":91},"obj":"DT"},{"id":"T282","span":{"begin":94,"end":102},"obj":"NN"},{"id":"T283","span":{"begin":92,"end":93},"obj":"NN"},{"id":"T284","span":{"begin":93,"end":94},"obj":"HYPH"},{"id":"T285","span":{"begin":103,"end":105},"obj":"IN"},{"id":"T286","span":{"begin":106,"end":109},"obj":"DT"},{"id":"T287","span":{"begin":115,"end":122},"obj":"NN"},{"id":"T288","span":{"begin":110,"end":114},"obj":"NN"},{"id":"T289","span":{"begin":122,"end":123},"obj":"."},{"id":"T290","span":{"begin":123,"end":320},"obj":"sentence"},{"id":"T291","span":{"begin":124,"end":129},"obj":"NN"},{"id":"T292","span":{"begin":149,"end":156},"obj":"NNS"},{"id":"T293","span":{"begin":130,"end":133},"obj":"CD"},{"id":"T294","span":{"begin":134,"end":140},"obj":"NN"},{"id":"T295","span":{"begin":133,"end":134},"obj":"HYPH"},{"id":"T296","span":{"begin":141,"end":148},"obj":"NN"},{"id":"T297","span":{"begin":167,"end":174},"obj":"VBN"},{"id":"T298","span":{"begin":157,"end":161},"obj":"VBD"},{"id":"T299","span":{"begin":162,"end":166},"obj":"RB"},{"id":"T300","span":{"begin":175,"end":178},"obj":"RP"},{"id":"T301","span":{"begin":179,"end":181},"obj":"TO"},{"id":"T302","span":{"begin":182,"end":190},"obj":"VB"},{"id":"T303","span":{"begin":191,"end":196},"obj":"NN"},{"id":"T304","span":{"begin":197,"end":206},"obj":"VBN"},{"id":"T305","span":{"begin":196,"end":197},"obj":"HYPH"},{"id":"T306","span":{"begin":207,"end":215},"obj":"NN"},{"id":"T307","span":{"begin":216,"end":220},"obj":"WDT"},{"id":"T308","span":{"begin":221,"end":229},"obj":"VBP"},{"id":"T309","span":{"begin":230,"end":234},"obj":"IN"},{"id":"T310","span":{"begin":235,"end":238},"obj":"DT"},{"id":"T311","span":{"begin":250,"end":257},"obj":"NN"},{"id":"T312","span":{"begin":239,"end":240},"obj":"NN"},{"id":"T313","span":{"begin":241,"end":249},"obj":"JJ"},{"id":"T314","span":{"begin":240,"end":241},"obj":"HYPH"},{"id":"T315","span":{"begin":258,"end":261},"obj":"CC"},{"id":"T316","span":{"begin":262,"end":266},"obj":"IN"},{"id":"T317","span":{"begin":267,"end":270},"obj":"DT"},{"id":"T318","span":{"begin":313,"end":319},"obj":"NN"},{"id":"T319","span":{"begin":271,"end":277},"obj":"JJ"},{"id":"T320","span":{"begin":278,"end":282},"obj":"NN"},{"id":"T321","span":{"begin":283,"end":290},"obj":"NN"},{"id":"T322","span":{"begin":298,"end":307},"obj":"NN"},{"id":"T323","span":{"begin":290,"end":291},"obj":"HYPH"},{"id":"T324","span":{"begin":291,"end":297},"obj":"NN"},{"id":"T325","span":{"begin":297,"end":298},"obj":"HYPH"},{"id":"T326","span":{"begin":308,"end":312},"obj":"JJ"},{"id":"T327","span":{"begin":307,"end":308},"obj":"HYPH"},{"id":"T328","span":{"begin":319,"end":320},"obj":"."},{"id":"T329","span":{"begin":320,"end":490},"obj":"sentence"},{"id":"T330","span":{"begin":321,"end":326},"obj":"CD"},{"id":"T331","span":{"begin":350,"end":358},"obj":"NN"},{"id":"T332","span":{"begin":327,"end":332},"obj":"JJ"},{"id":"T333","span":{"begin":333,"end":337},"obj":"NN"},{"id":"T334","span":{"begin":338,"end":349},"obj":"VBG"},{"id":"T335","span":{"begin":337,"end":338},"obj":"HYPH"},{"id":"T336","span":{"begin":364,"end":374},"obj":"VBN"},{"id":"T337","span":{"begin":359,"end":363},"obj":"VBD"},{"id":"T338","span":{"begin":374,"end":376},"obj":":"},{"id":"T339","span":{"begin":376,"end":379},"obj":"DT"},{"id":"T340","span":{"begin":408,"end":415},"obj":"NN"},{"id":"T341","span":{"begin":380,"end":393},"obj":"JJ"},{"id":"T342","span":{"begin":394,"end":401},"obj":"NN"},{"id":"T343","span":{"begin":402,"end":403},"obj":"-LRB-"},{"id":"T344","span":{"begin":403,"end":406},"obj":"NN"},{"id":"T345","span":{"begin":406,"end":407},"obj":"-RRB-"},{"id":"T346","span":{"begin":416,"end":422},"obj":"NN"},{"id":"T347","span":{"begin":422,"end":424},"obj":","},{"id":"T348","span":{"begin":424,"end":427},"obj":"DT"},{"id":"T349","span":{"begin":435,"end":442},"obj":"NN"},{"id":"T350","span":{"begin":428,"end":434},"obj":"NN"},{"id":"T351","span":{"begin":443,"end":448},"obj":"NN"},{"id":"T352","span":{"begin":448,"end":450},"obj":","},{"id":"T353","span":{"begin":450,"end":453},"obj":"CC"},{"id":"T354","span":{"begin":454,"end":457},"obj":"DT"},{"id":"T355","span":{"begin":475,"end":482},"obj":"NN"},{"id":"T356","span":{"begin":458,"end":468},"obj":"JJ"},{"id":"T357","span":{"begin":469,"end":474},"obj":"NN"},{"id":"T358","span":{"begin":483,"end":489},"obj":"NN"},{"id":"T359","span":{"begin":489,"end":490},"obj":"."},{"id":"T360","span":{"begin":490,"end":624},"obj":"sentence"},{"id":"T361","span":{"begin":491,"end":496},"obj":"CD"},{"id":"T362","span":{"begin":513,"end":522},"obj":"NNS"},{"id":"T363","span":{"begin":497,"end":498},"obj":"NN"},{"id":"T364","span":{"begin":499,"end":507},"obj":"JJ"},{"id":"T365","span":{"begin":498,"end":499},"obj":"HYPH"},{"id":"T366","span":{"begin":508,"end":512},"obj":"NN"},{"id":"T367","span":{"begin":586,"end":593},"obj":"VBD"},{"id":"T368","span":{"begin":522,"end":524},"obj":","},{"id":"T369","span":{"begin":524,"end":534},"obj":"RB"},{"id":"T370","span":{"begin":535,"end":545},"obj":"VBN"},{"id":"T371","span":{"begin":546,"end":548},"obj":"IN"},{"id":"T372","span":{"begin":549,"end":557},"obj":"NNS"},{"id":"T373","span":{"begin":558,"end":562},"obj":"IN"},{"id":"T374","span":{"begin":563,"end":566},"obj":"NN"},{"id":"T375","span":{"begin":567,"end":580},"obj":"NNS"},{"id":"T376","span":{"begin":580,"end":582},"obj":","},{"id":"T377","span":{"begin":582,"end":585},"obj":"DT"},{"id":"T378","span":{"begin":594,"end":596},"obj":"CC"},{"id":"T379","span":{"begin":597,"end":606},"obj":"VBD"},{"id":"T380","span":{"begin":607,"end":610},"obj":"DT"},{"id":"T381","span":{"begin":611,"end":623},"obj":"NNS"},{"id":"T382","span":{"begin":623,"end":624},"obj":"."}],"relations":[{"id":"R88","pred":"dobj","subj":"T277","obj":"T275"},{"id":"R89","pred":"advmod","subj":"T278","obj":"T279"},{"id":"R90","pred":"amod","subj":"T279","obj":"T277"},{"id":"R93","pred":"pobj","subj":"T282","obj":"T280"},{"id":"R94","pred":"compound","subj":"T283","obj":"T282"},{"id":"R95","pred":"punct","subj":"T284","obj":"T282"},{"id":"R98","pred":"pobj","subj":"T287","obj":"T285"},{"id":"R99","pred":"compound","subj":"T288","obj":"T287"},{"id":"R102","pred":"nsubjpass","subj":"T292","obj":"T297"},{"id":"R103","pred":"nummod","subj":"T293","obj":"T294"},{"id":"R105","pred":"punct","subj":"T295","obj":"T294"},{"id":"R106","pred":"compound","subj":"T296","obj":"T292"},{"id":"R113","pred":"amod","subj":"T304","obj":"T306"},{"id":"R114","pred":"punct","subj":"T305","obj":"T304"},{"id":"R120","pred":"pobj","subj":"T311","obj":"T309"},{"id":"R121","pred":"npadvmod","subj":"T312","obj":"T313"},{"id":"R123","pred":"punct","subj":"T314","obj":"T313"},{"id":"R127","pred":"pobj","subj":"T318","obj":"T316"},{"id":"R128","pred":"amod","subj":"T319","obj":"T318"},{"id":"R129","pred":"nmod","subj":"T320","obj":"T318"},{"id":"R130","pred":"compound","subj":"T321","obj":"T322"},{"id":"R131","pred":"npadvmod","subj":"T322","obj":"T326"},{"id":"R132","pred":"punct","subj":"T323","obj":"T322"},{"id":"R133","pred":"compound","subj":"T324","obj":"T322"},{"id":"R134","pred":"punct","subj":"T325","obj":"T322"},{"id":"R136","pred":"punct","subj":"T327","obj":"T326"},{"id":"R139","pred":"nsubjpass","subj":"T331","obj":"T336"},{"id":"R140","pred":"amod","subj":"T332","obj":"T331"},{"id":"R141","pred":"npadvmod","subj":"T333","obj":"T334"},{"id":"R143","pred":"punct","subj":"T335","obj":"T334"},{"id":"R147","pred":"dep","subj":"T340","obj":"T336"},{"id":"R148","pred":"amod","subj":"T341","obj":"T342"},{"id":"R149","pred":"nmod","subj":"T342","obj":"T340"},{"id":"R150","pred":"punct","subj":"T343","obj":"T342"},{"id":"R151","pred":"appos","subj":"T344","obj":"T342"},{"id":"R152","pred":"punct","subj":"T345","obj":"T340"},{"id":"R156","pred":"conj","subj":"T349","obj":"T340"},{"id":"R157","pred":"compound","subj":"T350","obj":"T349"},{"id":"R162","pred":"conj","subj":"T355","obj":"T349"},{"id":"R163","pred":"amod","subj":"T356","obj":"T355"},{"id":"R164","pred":"compound","subj":"T357","obj":"T355"},{"id":"R168","pred":"nsubj","subj":"T362","obj":"T367"},{"id":"R169","pred":"npadvmod","subj":"T363","obj":"T364"},{"id":"R171","pred":"punct","subj":"T365","obj":"T364"},{"id":"R172","pred":"compound","subj":"T366","obj":"T362"},{"id":"R82","pred":"nsubj","subj":"T270","obj":"T271"},{"id":"R83","pred":"compound","subj":"T272","obj":"T273"},{"id":"R84","pred":"dobj","subj":"T273","obj":"T271"},{"id":"R85","pred":"aux","subj":"T274","obj":"T275"},{"id":"R86","pred":"advcl","subj":"T275","obj":"T271"},{"id":"R87","pred":"det","subj":"T276","obj":"T277"},{"id":"R91","pred":"prep","subj":"T280","obj":"T275"},{"id":"R92","pred":"det","subj":"T281","obj":"T282"},{"id":"R96","pred":"prep","subj":"T285","obj":"T282"},{"id":"R97","pred":"det","subj":"T286","obj":"T287"},{"id":"R100","pred":"punct","subj":"T289","obj":"T271"},{"id":"R101","pred":"nmod","subj":"T291","obj":"T292"},{"id":"R104","pred":"compound","subj":"T294","obj":"T292"},{"id":"R107","pred":"auxpass","subj":"T298","obj":"T297"},{"id":"R108","pred":"advmod","subj":"T299","obj":"T297"},{"id":"R109","pred":"prt","subj":"T300","obj":"T297"},{"id":"R110","pred":"aux","subj":"T301","obj":"T302"},{"id":"R111","pred":"advcl","subj":"T302","obj":"T297"},{"id":"R112","pred":"npadvmod","subj":"T303","obj":"T304"},{"id":"R115","pred":"dobj","subj":"T306","obj":"T302"},{"id":"R116","pred":"dep","subj":"T307","obj":"T308"},{"id":"R117","pred":"relcl","subj":"T308","obj":"T306"},{"id":"R118","pred":"prep","subj":"T309","obj":"T308"},{"id":"R119","pred":"det","subj":"T310","obj":"T311"},{"id":"R122","pred":"amod","subj":"T313","obj":"T311"},{"id":"R124","pred":"cc","subj":"T315","obj":"T309"},{"id":"R125","pred":"conj","subj":"T316","obj":"T309"},{"id":"R126","pred":"det","subj":"T317","obj":"T318"},{"id":"R135","pred":"amod","subj":"T326","obj":"T318"},{"id":"R137","pred":"punct","subj":"T328","obj":"T297"},{"id":"R138","pred":"nummod","subj":"T330","obj":"T331"},{"id":"R142","pred":"amod","subj":"T334","obj":"T331"},{"id":"R144","pred":"auxpass","subj":"T337","obj":"T336"},{"id":"R145","pred":"punct","subj":"T338","obj":"T336"},{"id":"R146","pred":"det","subj":"T339","obj":"T340"},{"id":"R153","pred":"appos","subj":"T346","obj":"T340"},{"id":"R154","pred":"punct","subj":"T347","obj":"T340"},{"id":"R155","pred":"det","subj":"T348","obj":"T349"},{"id":"R158","pred":"appos","subj":"T351","obj":"T349"},{"id":"R159","pred":"punct","subj":"T352","obj":"T349"},{"id":"R160","pred":"cc","subj":"T353","obj":"T349"},{"id":"R161","pred":"det","subj":"T354","obj":"T355"},{"id":"R165","pred":"appos","subj":"T358","obj":"T355"},{"id":"R166","pred":"punct","subj":"T359","obj":"T336"},{"id":"R167","pred":"nummod","subj":"T361","obj":"T362"},{"id":"R170","pred":"amod","subj":"T364","obj":"T362"},{"id":"R173","pred":"punct","subj":"T368","obj":"T362"},{"id":"R174","pred":"advmod","subj":"T369","obj":"T370"},{"id":"R175","pred":"acl","subj":"T370","obj":"T362"},{"id":"R176","pred":"prep","subj":"T371","obj":"T370"},{"id":"R177","pred":"pobj","subj":"T372","obj":"T371"},{"id":"R178","pred":"prep","subj":"T373","obj":"T372"},{"id":"R179","pred":"compound","subj":"T374","obj":"T375"},{"id":"R180","pred":"pobj","subj":"T375","obj":"T373"},{"id":"R181","pred":"punct","subj":"T376","obj":"T362"},{"id":"R182","pred":"appos","subj":"T377","obj":"T362"},{"id":"R183","pred":"cc","subj":"T378","obj":"T367"},{"id":"R184","pred":"conj","subj":"T379","obj":"T367"},{"id":"R185","pred":"det","subj":"T380","obj":"T381"},{"id":"R186","pred":"dobj","subj":"T381","obj":"T379"},{"id":"R187","pred":"punct","subj":"T382","obj":"T367"}],"text":"Results\nWe used bioinformatics techniques to characterise a highly conserved peptide at the C-terminus of the PAX6 protein. Yeast two-hybrid library screens were then carried out to identify brain-expressed proteins that interact with the C-terminal peptide and with the entire PAX6 proline-serine-threonine-rich domain. Three novel PAX6-interacting proteins were identified: the post-synaptic density (PSD) protein HOMER3, the dynein subunit DNCL1, and the tripartite motif protein TRIM11. Three C-terminal PAX6 mutations, previously identified in patients with eye malformations, all reduced or abolished the interactions."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T130","span":{"begin":67,"end":76},"obj":"SO_EXT:biological_conservation_process_or_quality"},{"id":"T131","span":{"begin":77,"end":84},"obj":"CHEBI_SO_EXT:peptide_or_peptide_region"},{"id":"T132","span":{"begin":92,"end":102},"obj":"CHEBI_SO_EXT:C_terminus_or_C_terminal_region"},{"id":"T133","span":{"begin":110,"end":114},"obj":"PR_EXT:000012318"},{"id":"T134","span":{"begin":115,"end":122},"obj":"CHEBI_PR_EXT:protein"},{"id":"T135","span":{"begin":124,"end":129},"obj":"NCBITaxon_EXT:yeast"},{"id":"T136","span":{"begin":191,"end":196},"obj":"UBERON:0000955"},{"id":"T137","span":{"begin":197,"end":206},"obj":"GO:0010467"},{"id":"T138","span":{"begin":207,"end":215},"obj":"CHEBI_PR_EXT:protein"},{"id":"T139","span":{"begin":239,"end":249},"obj":"CHEBI_SO_EXT:C_terminus_or_C_terminal_region"},{"id":"T140","span":{"begin":250,"end":257},"obj":"CHEBI_SO_EXT:peptide_or_peptide_region"},{"id":"T141","span":{"begin":278,"end":282},"obj":"PR_EXT:000012318"},{"id":"T142","span":{"begin":283,"end":290},"obj":"CHEBI_SO_EXT:proline"},{"id":"T143","span":{"begin":291,"end":297},"obj":"CHEBI_SO_EXT:serine"},{"id":"T144","span":{"begin":298,"end":307},"obj":"CHEBI_SO_EXT:threonine"},{"id":"T145","span":{"begin":313,"end":319},"obj":"SO_EXT:0000417"},{"id":"T146","span":{"begin":333,"end":337},"obj":"PR_EXT:000012318"},{"id":"T147","span":{"begin":350,"end":358},"obj":"CHEBI_PR_EXT:protein"},{"id":"T148","span":{"begin":380,"end":401},"obj":"GO:0014069"},{"id":"T149","span":{"begin":403,"end":406},"obj":"GO:0014069"},{"id":"T150","span":{"begin":408,"end":415},"obj":"CHEBI_PR_EXT:protein"},{"id":"T151","span":{"begin":416,"end":422},"obj":"PR_EXT:000008680"},{"id":"T152","span":{"begin":428,"end":434},"obj":"GO:0030286"},{"id":"T153","span":{"begin":443,"end":448},"obj":"PR_EXT:000002325"},{"id":"T154","span":{"begin":469,"end":474},"obj":"SO_EXT:sequence_or_structure_motif"},{"id":"T155","span":{"begin":475,"end":482},"obj":"CHEBI_PR_EXT:protein"},{"id":"T156","span":{"begin":483,"end":489},"obj":"PR_EXT:000016642"},{"id":"T157","span":{"begin":497,"end":507},"obj":"CHEBI_SO_EXT:C_terminus_or_C_terminal_region"},{"id":"T158","span":{"begin":508,"end":512},"obj":"PR_EXT:000012318"},{"id":"T159","span":{"begin":513,"end":522},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T160","span":{"begin":563,"end":566},"obj":"UBERON:0000970"}],"text":"Results\nWe used bioinformatics techniques to characterise a highly conserved peptide at the C-terminus of the PAX6 protein. Yeast two-hybrid library screens were then carried out to identify brain-expressed proteins that interact with the C-terminal peptide and with the entire PAX6 proline-serine-threonine-rich domain. Three novel PAX6-interacting proteins were identified: the post-synaptic density (PSD) protein HOMER3, the dynein subunit DNCL1, and the tripartite motif protein TRIM11. Three C-terminal PAX6 mutations, previously identified in patients with eye malformations, all reduced or abolished the interactions."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T82","span":{"begin":278,"end":282},"obj":"PR:000012318"},{"id":"T83","span":{"begin":313,"end":319},"obj":"SO:0000417"},{"id":"T84","span":{"begin":333,"end":337},"obj":"PR:000012318"},{"id":"T85","span":{"begin":380,"end":401},"obj":"GO:0014069"},{"id":"T86","span":{"begin":403,"end":406},"obj":"GO:0014069"},{"id":"T87","span":{"begin":416,"end":422},"obj":"PR:000008680"},{"id":"T88","span":{"begin":428,"end":434},"obj":"GO:0030286"},{"id":"T89","span":{"begin":443,"end":448},"obj":"PR:000002325"},{"id":"T90","span":{"begin":483,"end":489},"obj":"PR:000016642"},{"id":"T91","span":{"begin":508,"end":512},"obj":"PR:000012318"},{"id":"T92","span":{"begin":563,"end":566},"obj":"UBERON:0000970"},{"id":"T79","span":{"begin":110,"end":114},"obj":"PR:000012318"},{"id":"T80","span":{"begin":191,"end":196},"obj":"UBERON:0000955"},{"id":"T81","span":{"begin":197,"end":206},"obj":"GO:0010467"}],"text":"Results\nWe used bioinformatics techniques to characterise a highly conserved peptide at the C-terminus of the PAX6 protein. Yeast two-hybrid library screens were then carried out to identify brain-expressed proteins that interact with the C-terminal peptide and with the entire PAX6 proline-serine-threonine-rich domain. Three novel PAX6-interacting proteins were identified: the post-synaptic density (PSD) protein HOMER3, the dynein subunit DNCL1, and the tripartite motif protein TRIM11. Three C-terminal PAX6 mutations, previously identified in patients with eye malformations, all reduced or abolished the interactions."}