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PMC:1208879 / 22713-23526 JSONTXT

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Id Subject Object Predicate Lexical cue
T6214 812-813 . denotes .
T6213 811-812 -RRB- denotes ]
T6212 809-811 CD denotes 28
T6211 808-809 -LRB- denotes [
T6210 790-791 HYPH denotes -
T6209 791-799 JJ denotes terminal
T6208 789-790 NN denotes C
T6207 800-807 NN denotes peptide
T6206 785-788 DT denotes the
T6205 782-784 IN denotes of
T6204 770-775 NN denotes amino
T6203 768-769 CD denotes 5
T6202 763-767 JJ denotes last
T6201 776-781 NNS denotes acids
T6200 759-762 DT denotes the
T6199 746-750 RB denotes also
T6198 751-758 VBZ denotes removes
T6197 727-736 NN denotes 1615del10
T6196 737-745 NN denotes mutation
T6195 723-726 DT denotes The
T6194 722-813 sentence denotes The 1615del10 mutation also removes the last 5 amino acids of the C-terminal peptide [28].
T6193 721-722 . denotes .
T6192 714-721 NN denotes protein
T6191 710-713 DT denotes the
T6190 707-709 IN denotes of
T6189 693-694 HYPH denotes -
T6188 694-702 JJ denotes terminal
T6187 692-693 NN denotes C
T6186 703-706 NN denotes end
T6185 688-691 DT denotes the
T6184 685-687 IN denotes of
T6183 672-684 NN denotes conformation
T6182 668-671 DT denotes the
T6181 660-667 VB denotes disrupt
T6180 657-659 TO denotes to
T6179 645-647 VB denotes be
T6178 639-644 MD denotes might
T6177 648-656 VBN denotes expected
T6176 634-638 WDT denotes that
T6175 623-633 NNS denotes extensions
T6174 614-622 JJ denotes abnormal
T6173 609-613 IN denotes with
T6172 600-608 NN denotes proteins
T6171 589-599 VBG denotes generating
T6170 584-588 RB denotes thus
T6169 582-584 , denotes ,
T6168 563-575 JJ denotes untranslated
T6167 561-562 SYM denotes '
T6166 560-561 CD denotes 3
T6165 576-582 NN denotes region
T6164 556-559 DT denotes the
T6163 551-555 IN denotes into
T6162 539-550 NN denotes translation
T6161 533-538 VB denotes cause
T6160 530-532 TO denotes to
T6159 507-516 NN denotes 1615del10
T6158 503-506 CC denotes and
T6157 497-502 NN denotes X423L
T6156 517-526 NNS denotes mutations
T6155 493-496 DT denotes the
T6154 490-492 IN denotes of
T6153 527-529 VBZ denotes is
T6152 473-482 VBN denotes predicted
T6151 483-489 NN denotes effect
T6150 469-472 DT denotes The
T6149 468-722 sentence denotes The predicted effect of the X423L and 1615del10 mutations is to cause translation into the 3' untranslated region, thus generating proteins with abnormal extensions that might be expected to disrupt the conformation of the C-terminal end of the protein.
T6148 467-468 . denotes .
T6147 462-467 NN denotes DNCL1
T6146 458-461 CC denotes and
T6145 451-457 NN denotes HOMER3
T6144 446-450 IN denotes with
T6143 434-445 NN denotes interaction
T6142 430-433 DT denotes the
T6141 420-429 VBD denotes abolished
T6140 409-419 RB denotes completely
T6139 406-408 CC denotes or
T6138 389-397 RB denotes severely
T6137 398-405 VBN denotes reduced
T6136 369-378 NN denotes 1615del10
T6135 365-368 CC denotes and
T6134 359-364 NN denotes X423L
T6133 379-388 NNS denotes mutations
T6132 355-358 DT denotes The
T6131 354-468 sentence denotes The X423L and 1615del10 mutations severely reduced or completely abolished the interaction with HOMER3 and DNCL1.
T6130 353-354 . denotes .
T6129 348-353 NN denotes DNCL1
T6128 344-347 CC denotes and
T6127 337-343 NN denotes HOMER3
T6126 332-336 IN denotes with
T6125 320-331 NN denotes interaction
T6124 316-319 DT denotes the
T6123 313-315 IN denotes in
T6122 303-312 NN denotes reduction
T6121 301-302 DT denotes a
T6120 292-294 , denotes ,
T6119 288-292 NN denotes PAX6
T6118 285-287 IN denotes of
T6117 271-275 NN denotes acid
T6116 265-270 NN denotes amino
T6115 260-264 JJ denotes last
T6114 276-284 NN denotes position
T6113 256-259 DT denotes the
T6112 253-255 IN denotes at
T6111 231-239 NN denotes arginine
T6110 228-230 IN denotes to
T6109 218-227 NN denotes glutamine
T6108 240-252 NN denotes substitution
T6107 216-217 DT denotes a
T6106 207-215 VBZ denotes involves
T6105 201-206 WDT denotes which
T6104 199-201 , denotes ,
T6103 294-300 VBD denotes caused
T6102 185-190 NN denotes Q422R
T6101 191-199 NN denotes mutation
T6100 181-184 DT denotes The
T6099 180-354 sentence denotes The Q422R mutation, which involves a glutamine to arginine substitution at the last amino acid position of PAX6, caused a reduction in the interaction with HOMER3 and DNCL1.
T6098 179-180 . denotes .
T6097 162-163 HYPH denotes -
T6096 163-171 JJ denotes terminal
T6095 161-162 NN denotes C
T6094 156-160 NN denotes PAX6
T6093 172-179 NN denotes peptide
T6092 152-155 DT denotes the
T6091 149-151 IN denotes in
T6090 137-140 VBP denotes are
T6089 141-148 VBN denotes located
T6088 132-136 WDT denotes that
T6087 112-121 VBG denotes occurring
T6086 102-111 RB denotes naturally
T6085 122-131 NNS denotes mutations
T6084 96-101 CD denotes three
T6083 93-95 IN denotes by
T6082 80-83 VBD denotes was
T6081 74-79 NN denotes DNCL1
T6080 71-73 CC denotes or
T6079 64-70 NN denotes HOMER3
T6078 60-63 CC denotes and
T6077 49-52 NN denotes PST
T6076 53-59 NN denotes domain
T6075 45-48 DT denotes the
T6074 37-44 IN denotes between
T6073 25-36 NN denotes interaction
T6072 21-24 DT denotes the
T6071 84-92 VBN denotes impaired
T6070 16-20 IN denotes that
T6069 3-15 VBD denotes demonstrated
T6068 0-2 PRP denotes We
R3709 T6172 T6171 dobj proteins,generating
R3711 T6068 T6069 nsubj We,demonstrated
R3712 T6173 T6172 prep with,proteins
R3713 T6070 T6071 mark that,impaired
R3714 T6071 T6069 ccomp impaired,demonstrated
R3715 T6072 T6073 det the,interaction
R3716 T6073 T6071 nsubjpass interaction,impaired
R3717 T6174 T6175 amod abnormal,extensions
R3718 T6074 T6073 prep between,interaction
R3719 T6075 T6076 det the,domain
R3720 T6175 T6173 pobj extensions,with
R3721 T6076 T6074 pobj domain,between
R3722 T6077 T6076 compound PST,domain
R3723 T6078 T6076 cc and,domain
R3724 T6176 T6177 dep that,expected
R3725 T6079 T6076 conj HOMER3,domain
R3726 T6080 T6079 cc or,HOMER3
R3727 T6081 T6079 conj DNCL1,HOMER3
R3728 T6177 T6172 relcl expected,proteins
R3729 T6082 T6071 auxpass was,impaired
R3730 T6083 T6071 agent by,impaired
R3731 T6084 T6085 nummod three,mutations
R3732 T6178 T6177 aux might,expected
R3733 T6085 T6083 pobj mutations,by
R3734 T6086 T6087 advmod naturally,occurring
R3735 T6087 T6085 amod occurring,mutations
R3736 T6179 T6177 auxpass be,expected
R3737 T6088 T6089 dep that,located
R3738 T6089 T6085 relcl located,mutations
R3739 T6090 T6089 auxpass are,located
R3740 T6091 T6089 prep in,located
R3741 T6180 T6181 aux to,disrupt
R3742 T6092 T6093 det the,peptide
R3743 T6093 T6091 pobj peptide,in
R3744 T6181 T6177 xcomp disrupt,expected
R3745 T6094 T6093 nmod PAX6,peptide
R3746 T6095 T6096 npadvmod C,terminal
R3747 T6096 T6093 amod terminal,peptide
R3748 T6182 T6183 det the,conformation
R3749 T6097 T6096 punct -,terminal
R3750 T6098 T6069 punct .,demonstrated
R3751 T6183 T6181 dobj conformation,disrupt
R3752 T6100 T6101 det The,mutation
R3753 T6101 T6103 nsubj mutation,caused
R3754 T6102 T6101 compound Q422R,mutation
R3755 T6104 T6101 punct ", ",mutation
R3756 T6105 T6106 dep which,involves
R3757 T6184 T6183 prep of,conformation
R3758 T6106 T6101 relcl involves,mutation
R3759 T6107 T6108 det a,substitution
R3760 T6108 T6106 dobj substitution,involves
R3761 T6185 T6186 det the,end
R3762 T6109 T6108 nmod glutamine,substitution
R3763 T6110 T6109 prep to,glutamine
R3764 T6186 T6184 pobj end,of
R3765 T6111 T6110 pobj arginine,to
R3766 T6112 T6108 prep at,substitution
R3767 T6113 T6114 det the,position
R3768 T6187 T6188 npadvmod C,terminal
R3769 T6114 T6112 pobj position,at
R3770 T6115 T6114 amod last,position
R3771 T6116 T6117 compound amino,acid
R3772 T6117 T6114 compound acid,position
R3773 T6188 T6186 amod terminal,end
R3774 T6118 T6114 prep of,position
R3775 T6119 T6118 pobj PAX6,of
R3776 T6189 T6188 punct -,terminal
R3777 T6120 T6103 punct ", ",caused
R3778 T6121 T6122 det a,reduction
R3779 T6122 T6103 dobj reduction,caused
R3780 T6123 T6122 prep in,reduction
R3781 T6190 T6186 prep of,end
R3782 T6124 T6125 det the,interaction
R3783 T6191 T6192 det the,protein
R3784 T6125 T6123 pobj interaction,in
R3785 T6126 T6125 prep with,interaction
R3786 T6127 T6126 pobj HOMER3,with
R3787 T6192 T6190 pobj protein,of
R3788 T6128 T6127 cc and,HOMER3
R3789 T6129 T6127 conj DNCL1,HOMER3
R3790 T6130 T6103 punct .,caused
R3791 T6193 T6153 punct .,is
R3792 T6132 T6133 det The,mutations
R3793 T6195 T6196 det The,mutation
R3794 T6133 T6137 nsubj mutations,reduced
R3795 T6134 T6133 nmod X423L,mutations
R3796 T6135 T6134 cc and,X423L
R3797 T6136 T6134 conj 1615del10,X423L
R3798 T6196 T6198 nsubj mutation,removes
R3799 T6138 T6137 advmod severely,reduced
R3800 T6139 T6137 cc or,reduced
R3801 T6197 T6196 compound 1615del10,mutation
R3802 T6140 T6141 advmod completely,abolished
R3803 T6141 T6137 conj abolished,reduced
R3804 T6142 T6143 det the,interaction
R3805 T6199 T6198 advmod also,removes
R3806 T6143 T6141 dobj interaction,abolished
R3807 T6144 T6143 prep with,interaction
R3808 T6145 T6144 pobj HOMER3,with
R3809 T6146 T6145 cc and,HOMER3
R3810 T6147 T6145 conj DNCL1,HOMER3
R3811 T6148 T6137 punct .,reduced
R3812 T6200 T6201 det the,acids
R3813 T6150 T6151 det The,effect
R3814 T6151 T6153 nsubj effect,is
R3815 T6152 T6151 amod predicted,effect
R3816 T6201 T6198 dobj acids,removes
R3817 T6154 T6151 prep of,effect
R3818 T6155 T6156 det the,mutations
R3819 T6202 T6201 amod last,acids
R3820 T6156 T6154 pobj mutations,of
R3821 T6157 T6156 nmod X423L,mutations
R3822 T6203 T6201 nummod 5,acids
R3823 T6158 T6157 cc and,X423L
R3824 T6159 T6157 conj 1615del10,X423L
R3825 T6160 T6161 aux to,cause
R3826 T6204 T6201 compound amino,acids
R3827 T6161 T6153 xcomp cause,is
R3828 T6162 T6161 dobj translation,cause
R3829 T6205 T6201 prep of,acids
R3830 T6163 T6162 prep into,translation
R3831 T6164 T6165 det the,region
R3832 T6165 T6163 pobj region,into
R3833 T6206 T6207 det the,peptide
R3834 T6166 T6165 nummod 3,region
R3835 T6167 T6166 punct ',3
R3836 T6168 T6165 amod untranslated,region
R3837 T6169 T6161 punct ", ",cause
R3838 T6207 T6205 pobj peptide,of
R3839 T6170 T6171 advmod thus,generating
R3840 T6171 T6161 advcl generating,cause
R3841 T6208 T6209 npadvmod C,terminal
R3842 T6209 T6207 amod terminal,peptide
R3843 T6210 T6209 punct -,terminal
R3846 T6211 T6212 punct [,28
R3850 T6212 T6198 parataxis 28,removes
R3853 T6213 T6212 punct ],28
R3856 T6214 T6198 punct .,removes

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T5035 800-807 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T5034 789-799 CHEBI_SO_EXT:C_terminus_or_C_terminal_region denotes C-terminal
T5033 770-781 CHEBI_SO_EXT:amino_acid denotes amino acids
T5032 737-745 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5031 714-721 CHEBI_PR_EXT:protein denotes protein
T5030 692-702 CHEBI_SO_EXT:C_terminus_or_C_terminal_region denotes C-terminal
T5029 600-608 CHEBI_PR_EXT:protein denotes proteins
T5028 565-575 GO:0006412 denotes translated
T5027 560-582 SO_EXT:0000205 denotes 3' untranslated region
T5026 539-550 GO:0006412 denotes translation
T5025 517-526 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T5024 462-467 PR_EXT:000002325 denotes DNCL1
T5023 451-457 PR_EXT:000008680 denotes HOMER3
T5022 379-388 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T5021 348-353 PR_EXT:000002325 denotes DNCL1
T5020 337-343 PR_EXT:000008680 denotes HOMER3
T5019 288-292 PR_EXT:000012318 denotes PAX6
T5018 265-275 CHEBI_SO_EXT:amino_acid denotes amino acid
T5017 240-252 SO_EXT:sequence_substitution_entity_or_process denotes substitution
T5016 231-239 CHEBI_SO_EXT:arginine denotes arginine
T5015 218-227 CHEBI_SO_EXT:glutamine denotes glutamine
T5014 191-199 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5013 172-179 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T5012 161-171 CHEBI_SO_EXT:C_terminus_or_C_terminal_region denotes C-terminal
T5011 156-160 PR_EXT:000012318 denotes PAX6
T5010 122-131 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T5009 74-79 PR_EXT:000002325 denotes DNCL1
T5008 64-70 PR_EXT:000008680 denotes HOMER3
T5007 53-59 SO_EXT:0000417 denotes domain

craft-ca-core-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T4730 64-70 PR:000008680 denotes HOMER3
T4729 53-59 SO:0000417 denotes domain
T4740 565-575 GO:0006412 denotes translated
T4739 560-582 SO:0000205 denotes 3' untranslated region
T4738 539-550 GO:0006412 denotes translation
T4737 462-467 PR:000002325 denotes DNCL1
T4736 451-457 PR:000008680 denotes HOMER3
T4735 348-353 PR:000002325 denotes DNCL1
T4734 337-343 PR:000008680 denotes HOMER3
T4733 288-292 PR:000012318 denotes PAX6
T4732 156-160 PR:000012318 denotes PAX6
T4731 74-79 PR:000002325 denotes DNCL1