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present our data must be considered preliminary because the interactions have not been confirmed by any other approach. However it is interesting to speculate that the interaction of PAX6 with HOMER3 and DNCL1 may be the basis of a mechanism by which synaptic signalling causes changes in gene expression. We propose that PAX6 is sequestered in the PSD by binding to HOMER3. Since receptor activation causes dissociation of HOMER proteins [35], PAX6 may be released as a result of synaptic activity, allowing it to interact with DNCL1. The PAX6/DNCL1 complex could then participate in myosin Va-mediated transport along the PSD-associated actin cytoskeleton followed by dynein-mediated transport along the microtubule network, eventually reaching the nucleus [36]. Since TRIM11 is implicated in protein degradation [46], it may play a role in PAX6 protein turnover."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T4932","span":{"begin":851,"end":858},"obj":"CHEBI_PR_EXT:protein"},{"id":"T4931","span":{"begin":846,"end":850},"obj":"PR_EXT:000012318"},{"id":"T4930","span":{"begin":798,"end":817},"obj":"GO:0030163"},{"id":"T4929","span":{"begin":798,"end":805},"obj":"CHEBI_PR_EXT:protein"},{"id":"T4928","span":{"begin":774,"end":780},"obj":"PR_EXT:000016642"},{"id":"T4927","span":{"begin":754,"end":761},"obj":"GO:0005634"},{"id":"T4926","span":{"begin":709,"end":720},"obj":"GO:0005874"},{"id":"T4925","span":{"begin":689,"end":698},"obj":"GO_EXT:biological_routing_or_transport"},{"id":"T4924","span":{"begin":673,"end":679},"obj":"GO:0030286"},{"id":"T4923","span":{"begin":642,"end":660},"obj":"GO:0015629"},{"id":"T4922","span":{"begin":627,"end":630},"obj":"GO:0014069"},{"id":"T4921","span":{"begin":607,"end":616},"obj":"GO_EXT:biological_routing_or_transport"},{"id":"T4920","span":{"begin":588,"end":597},"obj":"PR_EXT:000010865"},{"id":"T4919","span":{"begin":554,"end":561},"obj":"GO:0032991"},{"id":"T4918","span":{"begin":548,"end":553},"obj":"PR_EXT:000002325"},{"id":"T4917","span":{"begin":543,"end":547},"obj":"PR_EXT:000012318"},{"id":"T4916","span":{"begin":532,"end":537},"obj":"PR_EXT:000002325"},{"id":"T4915","span":{"begin":484,"end":492},"obj":"GO:0045202"},{"id":"T4914","span":{"begin":460,"end":468},"obj":"GO_EXT:biological_release"},{"id":"T4913","span":{"begin":448,"end":452},"obj":"PR_EXT:000012318"},{"id":"T4912","span":{"begin":433,"end":441},"obj":"CHEBI_PR_EXT:protein"},{"id":"T4911","span":{"begin":427,"end":432},"obj":"PR_EXT:HOMER"},{"id":"T4910","span":{"begin":384,"end":392},"obj":"GO_EXT:0004872"},{"id":"T4909","span":{"begin":370,"end":376},"obj":"PR_EXT:000008680"},{"id":"T4908","span":{"begin":359,"end":366},"obj":"CHEMINF_GO_EXT:chemical_binding_or_bond_formation"},{"id":"T4906","span":{"begin":352,"end":355},"obj":"GO:0014069"},{"id":"T4905","span":{"begin":333,"end":344},"obj":"GO:0051235"},{"id":"T4904","span":{"begin":325,"end":329},"obj":"PR_EXT:000012318"},{"id":"T4903","span":{"begin":292,"end":307},"obj":"GO:0010467"},{"id":"T4902","span":{"begin":292,"end":296},"obj":"SO_EXT:0000704"},{"id":"T4901","span":{"begin":254,"end":273},"obj":"GO:0099536"},{"id":"T4900","span":{"begin":254,"end":262},"obj":"GO:0045202"},{"id":"T4899","span":{"begin":207,"end":212},"obj":"PR_EXT:000002325"},{"id":"T4898","span":{"begin":196,"end":202},"obj":"PR_EXT:000008680"},{"id":"T4897","span":{"begin":186,"end":190},"obj":"PR_EXT:000012318"}],"text":"At present our data must be considered preliminary because the interactions have not been confirmed by any other approach. However it is interesting to speculate that the interaction of PAX6 with HOMER3 and DNCL1 may be the basis of a mechanism by which synaptic signalling causes changes in gene expression. We propose that PAX6 is sequestered in the PSD by binding to HOMER3. Since receptor activation causes dissociation of HOMER proteins [35], PAX6 may be released as a result of synaptic activity, allowing it to interact with DNCL1. The PAX6/DNCL1 complex could then participate in myosin Va-mediated transport along the PSD-associated actin cytoskeleton followed by dynein-mediated transport along the microtubule network, eventually reaching the nucleus [36]. Since TRIM11 is implicated in protein degradation [46], it may play a role in PAX6 protein turnover."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T4672","span":{"begin":846,"end":850},"obj":"PR:000012318"},{"id":"T4671","span":{"begin":798,"end":817},"obj":"GO:0030163"},{"id":"T4670","span":{"begin":774,"end":780},"obj":"PR:000016642"},{"id":"T4669","span":{"begin":754,"end":761},"obj":"GO:0005634"},{"id":"T4668","span":{"begin":709,"end":720},"obj":"GO:0005874"},{"id":"T4667","span":{"begin":673,"end":679},"obj":"GO:0030286"},{"id":"T4666","span":{"begin":642,"end":660},"obj":"GO:0015629"},{"id":"T4665","span":{"begin":627,"end":630},"obj":"GO:0014069"},{"id":"T4664","span":{"begin":588,"end":597},"obj":"PR:000010865"},{"id":"T4663","span":{"begin":554,"end":561},"obj":"GO:0032991"},{"id":"T4662","span":{"begin":548,"end":553},"obj":"PR:000002325"},{"id":"T4661","span":{"begin":543,"end":547},"obj":"PR:000012318"},{"id":"T4660","span":{"begin":532,"end":537},"obj":"PR:000002325"},{"id":"T4659","span":{"begin":484,"end":492},"obj":"GO:0045202"},{"id":"T4658","span":{"begin":448,"end":452},"obj":"PR:000012318"},{"id":"T4657","span":{"begin":370,"end":376},"obj":"PR:000008680"},{"id":"T4656","span":{"begin":352,"end":355},"obj":"GO:0014069"},{"id":"T4655","span":{"begin":333,"end":344},"obj":"GO:0051235"},{"id":"T4654","span":{"begin":325,"end":329},"obj":"PR:000012318"},{"id":"T4653","span":{"begin":292,"end":307},"obj":"GO:0010467"},{"id":"T4652","span":{"begin":292,"end":296},"obj":"SO:0000704"},{"id":"T4651","span":{"begin":254,"end":273},"obj":"GO:0099536"},{"id":"T4650","span":{"begin":254,"end":262},"obj":"GO:0045202"},{"id":"T4649","span":{"begin":207,"end":212},"obj":"PR:000002325"},{"id":"T4648","span":{"begin":196,"end":202},"obj":"PR:000008680"},{"id":"T4647","span":{"begin":186,"end":190},"obj":"PR:000012318"}],"text":"At present our data must be considered preliminary because the interactions have not been confirmed by any other approach. However it is interesting to speculate that the interaction of PAX6 with HOMER3 and DNCL1 may be the basis of a mechanism by which synaptic signalling causes changes in gene expression. We propose that PAX6 is sequestered in the PSD by binding to HOMER3. Since receptor activation causes dissociation of HOMER proteins [35], PAX6 may be released as a result of synaptic activity, allowing it to interact with DNCL1. The PAX6/DNCL1 complex could then participate in myosin Va-mediated transport along the PSD-associated actin cytoskeleton followed by dynein-mediated transport along the microtubule network, eventually reaching the nucleus [36]. Since TRIM11 is implicated in protein degradation [46], it may play a role in PAX6 protein turnover."}