PMC:1208879 / 16952-17472
Annnotations
craft-sa-dev
{"project":"craft-sa-dev","denotations":[{"id":"T4280","span":{"begin":519,"end":520},"obj":"."},{"id":"T4279","span":{"begin":518,"end":519},"obj":"-RRB-"},{"id":"T4278","span":{"begin":517,"end":518},"obj":"CD"},{"id":"T4277","span":{"begin":509,"end":511},"obj":","},{"id":"T4276","span":{"begin":508,"end":509},"obj":"CD"},{"id":"T4275","span":{"begin":501,"end":507},"obj":"NN"},{"id":"T4274","span":{"begin":511,"end":516},"obj":"NN"},{"id":"T4273","span":{"begin":500,"end":501},"obj":"-LRB-"},{"id":"T4272","span":{"begin":494,"end":499},"obj":"NN"},{"id":"T4271","span":{"begin":490,"end":493},"obj":"CC"},{"id":"T4270","span":{"begin":483,"end":489},"obj":"NN"},{"id":"T4269","span":{"begin":478,"end":482},"obj":"IN"},{"id":"T4268","span":{"begin":466,"end":477},"obj":"NN"},{"id":"T4267","span":{"begin":462,"end":465},"obj":"DT"},{"id":"T4266","span":{"begin":452,"end":461},"obj":"VBD"},{"id":"T4265","span":{"begin":449,"end":451},"obj":"CC"},{"id":"T4264","span":{"begin":428,"end":440},"obj":"RB"},{"id":"T4257","span":{"begin":374,"end":383},"obj":"NN"},{"id":"T4256","span":{"begin":364,"end":365},"obj":"HYPH"},{"id":"T4255","span":{"begin":365,"end":373},"obj":"JJ"},{"id":"T4254","span":{"begin":363,"end":364},"obj":"NN"},{"id":"T4253","span":{"begin":394,"end":399},"obj":"NN"},{"id":"T4252","span":{"begin":359,"end":362},"obj":"DT"},{"id":"T4251","span":{"begin":358,"end":520},"obj":"sentence"},{"id":"T4250","span":{"begin":357,"end":358},"obj":"."},{"id":"T4249","span":{"begin":356,"end":357},"obj":"-RRB-"},{"id":"T4248","span":{"begin":355,"end":356},"obj":"CD"},{"id":"T4247","span":{"begin":347,"end":349},"obj":","},{"id":"T4246","span":{"begin":346,"end":347},"obj":"CD"},{"id":"T4245","span":{"begin":339,"end":345},"obj":"NN"},{"id":"T4244","span":{"begin":349,"end":354},"obj":"NN"},{"id":"T4243","span":{"begin":338,"end":339},"obj":"-LRB-"},{"id":"T4242","span":{"begin":332,"end":337},"obj":"NN"},{"id":"T4241","span":{"begin":328,"end":331},"obj":"CC"},{"id":"T4240","span":{"begin":321,"end":327},"obj":"NN"},{"id":"T4239","span":{"begin":316,"end":320},"obj":"IN"},{"id":"T4238","span":{"begin":304,"end":315},"obj":"NN"},{"id":"T4237","span":{"begin":300,"end":303},"obj":"DT"},{"id":"T4236","span":{"begin":297,"end":299},"obj":"IN"},{"id":"T4235","span":{"begin":287,"end":296},"obj":"NN"},{"id":"T4234","span":{"begin":285,"end":286},"obj":"DT"},{"id":"T4233","span":{"begin":276,"end":277},"obj":"-RRB-"},{"id":"T4232","span":{"begin":271,"end":276},"obj":"NN"},{"id":"T4231","span":{"begin":270,"end":271},"obj":"-LRB-"},{"id":"T4230","span":{"begin":278,"end":284},"obj":"VBD"},{"id":"T4229","span":{"begin":254,"end":260},"obj":"JJ"},{"id":"T4228","span":{"begin":249,"end":253},"obj":"RBS"},{"id":"T4227","span":{"begin":261,"end":269},"obj":"NN"},{"id":"T4226","span":{"begin":245,"end":248},"obj":"DT"},{"id":"T4225","span":{"begin":244,"end":358},"obj":"sentence"},{"id":"T4224","span":{"begin":243,"end":244},"obj":"."},{"id":"T4223","span":{"begin":231,"end":243},"obj":"NNS"},{"id":"T4222","span":{"begin":227,"end":230},"obj":"DT"},{"id":"T4221","span":{"begin":224,"end":226},"obj":"IN"},{"id":"T4220","span":{"begin":211,"end":216},"obj":"JJ"},{"id":"T4219","span":{"begin":217,"end":223},"obj":"NN"},{"id":"T4218","span":{"begin":209,"end":210},"obj":"DT"},{"id":"T4217","span":{"begin":205,"end":208},"obj":"VBD"},{"id":"T4216","span":{"begin":189,"end":194},"obj":"CD"},{"id":"T4215","span":{"begin":195,"end":204},"obj":"NNS"},{"id":"T4214","span":{"begin":185,"end":188},"obj":"DT"},{"id":"T4213","span":{"begin":184,"end":244},"obj":"sentence"},{"id":"T4212","span":{"begin":183,"end":184},"obj":"."},{"id":"T4211","span":{"begin":177,"end":183},"obj":"NN"},{"id":"T4210","span":{"begin":173,"end":176},"obj":"CC"},{"id":"T4209","span":{"begin":167,"end":172},"obj":"NN"},{"id":"T4208","span":{"begin":165,"end":167},"obj":","},{"id":"T4207","span":{"begin":159,"end":165},"obj":"NN"},{"id":"T4206","span":{"begin":154,"end":158},"obj":"IN"},{"id":"T4205","span":{"begin":139,"end":145},"obj":"NN"},{"id":"T4204","span":{"begin":146,"end":153},"obj":"NN"},{"id":"T4203","span":{"begin":134,"end":138},"obj":"DT"},{"id":"T4202","span":{"begin":131,"end":133},"obj":"IN"},{"id":"T4201","span":{"begin":119,"end":130},"obj":"NN"},{"id":"T4200","span":{"begin":115,"end":118},"obj":"DT"},{"id":"T4199","span":{"begin":103,"end":114},"obj":"VB"},{"id":"T4198","span":{"begin":100,"end":102},"obj":"TO"},{"id":"T4197","span":{"begin":96,"end":99},"obj":"RP"},{"id":"T4196","span":{"begin":83,"end":87},"obj":"VBD"},{"id":"T4195","span":{"begin":88,"end":95},"obj":"VBN"},{"id":"T4194","span":{"begin":77,"end":82},"obj":"NNS"},{"id":"T4193","span":{"begin":68,"end":76},"obj":"JJ"},{"id":"T4192","span":{"begin":64,"end":67},"obj":"CC"},{"id":"T4191","span":{"begin":62,"end":64},"obj":","},{"id":"T4190","span":{"begin":45,"end":52},"obj":"NN"},{"id":"T4189","span":{"begin":53,"end":62},"obj":"NN"},{"id":"T4188","span":{"begin":41,"end":44},"obj":"DT"},{"id":"T4187","span":{"begin":36,"end":40},"obj":"IN"},{"id":"T4186","span":{"begin":20,"end":24},"obj":"VBD"},{"id":"T4185","span":{"begin":25,"end":35},"obj":"VBN"},{"id":"T4184","span":{"begin":4,"end":9},"obj":"CD"},{"id":"T4183","span":{"begin":10,"end":19},"obj":"NNS"},{"id":"T4182","span":{"begin":0,"end":3},"obj":"DT"},{"id":"T4263","span":{"begin":423,"end":427},"obj":"DT"},{"id":"T4262","span":{"begin":413,"end":422},"obj":"NNS"},{"id":"T4261","span":{"begin":403,"end":412},"obj":"NN"},{"id":"T4260","span":{"begin":400,"end":403},"obj":"CC"},{"id":"T4259","span":{"begin":441,"end":448},"obj":"VBD"},{"id":"T4258","span":{"begin":384,"end":393},"obj":"NNS"}],"relations":[{"id":"R2647","pred":"det","subj":"T4182","obj":"T4183"},{"id":"R2648","pred":"nsubjpass","subj":"T4183","obj":"T4185"},{"id":"R2649","pred":"nummod","subj":"T4184","obj":"T4183"},{"id":"R2650","pred":"auxpass","subj":"T4186","obj":"T4185"},{"id":"R2651","pred":"prep","subj":"T4187","obj":"T4185"},{"id":"R2652","pred":"det","subj":"T4188","obj":"T4189"},{"id":"R2653","pred":"pobj","subj":"T4189","obj":"T4187"},{"id":"R2654","pred":"compound","subj":"T4190","obj":"T4189"},{"id":"R2655","pred":"punct","subj":"T4191","obj":"T4185"},{"id":"R2656","pred":"cc","subj":"T4192","obj":"T4185"},{"id":"R2657","pred":"amod","subj":"T4193","obj":"T4194"},{"id":"R2658","pred":"nsubjpass","subj":"T4194","obj":"T4195"},{"id":"R2659","pred":"conj","subj":"T4195","obj":"T4185"},{"id":"R2660","pred":"auxpass","subj":"T4196","obj":"T4195"},{"id":"R2661","pred":"prt","subj":"T4197","obj":"T4195"},{"id":"R2662","pred":"aux","subj":"T4198","obj":"T4199"},{"id":"R2663","pred":"advcl","subj":"T4199","obj":"T4195"},{"id":"R2664","pred":"det","subj":"T4200","obj":"T4201"},{"id":"R2665","pred":"dobj","subj":"T4201","obj":"T4199"},{"id":"R2666","pred":"prep","subj":"T4202","obj":"T4201"},{"id":"R2667","pred":"det","subj":"T4203","obj":"T4204"},{"id":"R2668","pred":"pobj","subj":"T4204","obj":"T4202"},{"id":"R2669","pred":"compound","subj":"T4205","obj":"T4204"},{"id":"R2670","pred":"prep","subj":"T4206","obj":"T4201"},{"id":"R2671","pred":"pobj","subj":"T4207","obj":"T4206"},{"id":"R2672","pred":"punct","subj":"T4208","obj":"T4207"},{"id":"R2673","pred":"conj","subj":"T4209","obj":"T4207"},{"id":"R2674","pred":"cc","subj":"T4210","obj":"T4209"},{"id":"R2675","pred":"conj","subj":"T4211","obj":"T4209"},{"id":"R2676","pred":"punct","subj":"T4212","obj":"T4195"},{"id":"R2677","pred":"det","subj":"T4214","obj":"T4215"},{"id":"R2678","pred":"nsubj","subj":"T4215","obj":"T4217"},{"id":"R2679","pred":"nummod","subj":"T4216","obj":"T4215"},{"id":"R2680","pred":"det","subj":"T4218","obj":"T4219"},{"id":"R2681","pred":"dobj","subj":"T4219","obj":"T4217"},{"id":"R2682","pred":"amod","subj":"T4220","obj":"T4219"},{"id":"R2683","pred":"prep","subj":"T4221","obj":"T4219"},{"id":"R2684","pred":"det","subj":"T4222","obj":"T4223"},{"id":"R2685","pred":"pobj","subj":"T4223","obj":"T4221"},{"id":"R2686","pred":"punct","subj":"T4224","obj":"T4217"},{"id":"R2687","pred":"det","subj":"T4226","obj":"T4227"},{"id":"R2688","pred":"nsubj","subj":"T4227","obj":"T4230"},{"id":"R2689","pred":"advmod","subj":"T4228","obj":"T4229"},{"id":"R2690","pred":"amod","subj":"T4229","obj":"T4227"},{"id":"R2691","pred":"punct","subj":"T4231","obj":"T4227"},{"id":"R2692","pred":"appos","subj":"T4232","obj":"T4227"},{"id":"R2693","pred":"punct","subj":"T4233","obj":"T4227"},{"id":"R2694","pred":"det","subj":"T4234","obj":"T4235"},{"id":"R2695","pred":"dobj","subj":"T4235","obj":"T4230"},{"id":"R2696","pred":"prep","subj":"T4236","obj":"T4235"},{"id":"R2697","pred":"det","subj":"T4237","obj":"T4238"},{"id":"R2698","pred":"pobj","subj":"T4238","obj":"T4236"},{"id":"R2699","pred":"prep","subj":"T4239","obj":"T4238"},{"id":"R2700","pred":"pobj","subj":"T4240","obj":"T4239"},{"id":"R2701","pred":"cc","subj":"T4241","obj":"T4240"},{"id":"R2702","pred":"conj","subj":"T4242","obj":"T4240"},{"id":"R2703","pred":"punct","subj":"T4243","obj":"T4244"},{"id":"R2704","pred":"parataxis","subj":"T4244","obj":"T4230"},{"id":"R2705","pred":"dep","subj":"T4245","obj":"T4244"},{"id":"R2706","pred":"nummod","subj":"T4246","obj":"T4245"},{"id":"R2707","pred":"punct","subj":"T4247","obj":"T4244"},{"id":"R2708","pred":"nummod","subj":"T4248","obj":"T4244"},{"id":"R2709","pred":"punct","subj":"T4249","obj":"T4244"},{"id":"R2710","pred":"punct","subj":"T4250","obj":"T4230"},{"id":"R2711","pred":"det","subj":"T4252","obj":"T4253"},{"id":"R2712","pred":"nsubj","subj":"T4253","obj":"T4259"},{"id":"R2713","pred":"npadvmod","subj":"T4254","obj":"T4255"},{"id":"R2714","pred":"amod","subj":"T4255","obj":"T4253"},{"id":"R2715","pred":"punct","subj":"T4256","obj":"T4255"},{"id":"R2716","pred":"compound","subj":"T4257","obj":"T4253"},{"id":"R2717","pred":"compound","subj":"T4258","obj":"T4253"},{"id":"R2718","pred":"cc","subj":"T4260","obj":"T4253"},{"id":"R2719","pred":"compound","subj":"T4261","obj":"T4262"},{"id":"R2720","pred":"conj","subj":"T4262","obj":"T4253"},{"id":"R2721","pred":"appos","subj":"T4263","obj":"T4253"},{"id":"R2722","pred":"advmod","subj":"T4264","obj":"T4259"},{"id":"R2723","pred":"cc","subj":"T4265","obj":"T4259"},{"id":"R2724","pred":"conj","subj":"T4266","obj":"T4259"},{"id":"R2725","pred":"det","subj":"T4267","obj":"T4268"},{"id":"R2726","pred":"dobj","subj":"T4268","obj":"T4266"},{"id":"R2727","pred":"prep","subj":"T4269","obj":"T4268"},{"id":"R2728","pred":"pobj","subj":"T4270","obj":"T4269"},{"id":"R2729","pred":"cc","subj":"T4271","obj":"T4270"},{"id":"R2730","pred":"conj","subj":"T4272","obj":"T4270"},{"id":"R2731","pred":"punct","subj":"T4273","obj":"T4274"},{"id":"R2732","pred":"parataxis","subj":"T4274","obj":"T4266"},{"id":"R2733","pred":"dep","subj":"T4275","obj":"T4274"},{"id":"R2734","pred":"nummod","subj":"T4276","obj":"T4275"},{"id":"R2735","pred":"punct","subj":"T4277","obj":"T4274"},{"id":"R2736","pred":"nummod","subj":"T4278","obj":"T4274"},{"id":"R2737","pred":"punct","subj":"T4279","obj":"T4274"},{"id":"R2738","pred":"punct","subj":"T4280","obj":"T4259"}],"text":"The three mutations were introduced into the PAX6PST construct, and pairwise tests were carried out to investigate the interaction of each mutant protein with HOMER3, DNCL1 and TRIM11. All three mutations had a clear effect on the interactions. The most subtle mutation (Q422R) caused a reduction in the interaction with HOMER3 and DNCL1 (Figure 3, Table 1). The C-terminal extension mutations X423L and1615del10 mutations both dramatically reduced or abolished the interaction with HOMER3 and DNCL1 (Figure 3, Table 1)."}
craft-ca-core-ex-dev
{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T3376","span":{"begin":494,"end":499},"obj":"PR_EXT:000002325"},{"id":"T3375","span":{"begin":483,"end":489},"obj":"PR_EXT:000008680"},{"id":"T3374","span":{"begin":413,"end":422},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T3373","span":{"begin":384,"end":393},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T3372","span":{"begin":363,"end":373},"obj":"CHEBI_SO_EXT:C_terminus_or_C_terminal_region"},{"id":"T3371","span":{"begin":332,"end":337},"obj":"PR_EXT:000002325"},{"id":"T3370","span":{"begin":321,"end":327},"obj":"PR_EXT:000008680"},{"id":"T3369","span":{"begin":261,"end":269},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T3368","span":{"begin":195,"end":204},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T3367","span":{"begin":177,"end":183},"obj":"PR_EXT:000016642"},{"id":"T3366","span":{"begin":167,"end":172},"obj":"PR_EXT:000002325"},{"id":"T3365","span":{"begin":159,"end":165},"obj":"PR_EXT:000008680"},{"id":"T3364","span":{"begin":146,"end":153},"obj":"CHEBI_PR_EXT:protein"},{"id":"T3363","span":{"begin":139,"end":145},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T3362","span":{"begin":53,"end":62},"obj":"SO_EXT:engineered_biological_sequence"},{"id":"T3361","span":{"begin":10,"end":19},"obj":"SO_EXT:sequence_alteration_entity_or_process"}],"text":"The three mutations were introduced into the PAX6PST construct, and pairwise tests were carried out to investigate the interaction of each mutant protein with HOMER3, DNCL1 and TRIM11. All three mutations had a clear effect on the interactions. The most subtle mutation (Q422R) caused a reduction in the interaction with HOMER3 and DNCL1 (Figure 3, Table 1). The C-terminal extension mutations X423L and1615del10 mutations both dramatically reduced or abolished the interaction with HOMER3 and DNCL1 (Figure 3, Table 1)."}
craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T3218","span":{"begin":494,"end":499},"obj":"PR:000002325"},{"id":"T3217","span":{"begin":483,"end":489},"obj":"PR:000008680"},{"id":"T3216","span":{"begin":332,"end":337},"obj":"PR:000002325"},{"id":"T3215","span":{"begin":321,"end":327},"obj":"PR:000008680"},{"id":"T3214","span":{"begin":177,"end":183},"obj":"PR:000016642"},{"id":"T3213","span":{"begin":167,"end":172},"obj":"PR:000002325"},{"id":"T3212","span":{"begin":159,"end":165},"obj":"PR:000008680"}],"text":"The three mutations were introduced into the PAX6PST construct, and pairwise tests were carried out to investigate the interaction of each mutant protein with HOMER3, DNCL1 and TRIM11. All three mutations had a clear effect on the interactions. The most subtle mutation (Q422R) caused a reduction in the interaction with HOMER3 and DNCL1 (Figure 3, Table 1). The C-terminal extension mutations X423L and1615del10 mutations both dramatically reduced or abolished the interaction with HOMER3 and DNCL1 (Figure 3, Table 1)."}