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PMC:1208879 / 1529-2458 JSONTXT

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Id Subject Object Predicate Lexical cue
T834 0-3 DT denotes The
T835 9-16 NN denotes protein
T836 4-8 NN denotes PAX6
T837 17-19 VBZ denotes is
T838 20-21 DT denotes a
T839 22-28 NN denotes member
T840 29-31 IN denotes of
T841 32-35 DT denotes the
T842 53-59 NN denotes family
T843 36-39 NN denotes PAX
T844 40-41 -LRB- denotes (
T845 41-47 VBN denotes paired
T846 48-51 NN denotes box
T847 47-48 HYPH denotes -
T848 51-52 -RRB- denotes )
T849 60-62 IN denotes of
T850 63-78 JJ denotes transcriptional
T851 79-89 NNS denotes regulators
T852 90-93 CC denotes and
T853 94-96 VBZ denotes is
T854 97-106 JJ denotes essential
T855 107-110 IN denotes for
T856 111-117 JJ denotes normal
T857 136-147 NN denotes development
T858 118-124 JJ denotes ocular
T859 125-128 CC denotes and
T860 129-135 JJ denotes neural
T861 148-149 -LRB- denotes [
T862 149-150 CD denotes 1
T863 150-151 -RRB- denotes ]
T864 151-152 . denotes .
T865 152-290 sentence denotes Heterozygous mutations of the human PAX6 gene cause aniridia (absence of the iris) and a range of other congenital eye malformations [2].
T866 153-165 JJ denotes Heterozygous
T867 166-175 NNS denotes mutations
T868 199-204 VBP denotes cause
T869 176-178 IN denotes of
T870 179-182 DT denotes the
T871 194-198 NN denotes gene
T872 183-188 JJ denotes human
T873 189-193 NN denotes PAX6
T874 205-213 NN denotes aniridia
T875 214-215 -LRB- denotes (
T876 215-222 NN denotes absence
T877 223-225 IN denotes of
T878 226-229 DT denotes the
T879 230-234 NN denotes iris
T880 234-235 -RRB- denotes )
T881 236-239 CC denotes and
T882 240-241 DT denotes a
T883 242-247 NN denotes range
T884 248-250 IN denotes of
T885 251-256 JJ denotes other
T886 272-285 NNS denotes malformations
T887 257-267 JJ denotes congenital
T888 268-271 NN denotes eye
T889 286-287 -LRB- denotes [
T890 287-288 CD denotes 2
T891 288-289 -RRB- denotes ]
T892 289-290 . denotes .
T893 290-407 sentence denotes Neural defects such as foveal hypoplasia and optic nerve hypoplasia are common in PAX6-associated eye disease [3-5].
T894 291-297 JJ denotes Neural
T895 298-305 NNS denotes defects
T896 359-362 VBP denotes are
T897 306-310 JJ denotes such
T898 311-313 IN denotes as
T899 314-320 JJ denotes foveal
T900 321-331 NN denotes hypoplasia
T901 332-335 CC denotes and
T902 336-341 JJ denotes optic
T903 342-347 NN denotes nerve
T904 348-358 NN denotes hypoplasia
T905 363-369 JJ denotes common
T906 370-372 IN denotes in
T907 373-377 NN denotes PAX6
T908 378-388 VBN denotes associated
T909 377-378 HYPH denotes -
T910 393-400 NN denotes disease
T911 389-392 NN denotes eye
T912 401-402 -LRB- denotes [
T913 402-403 CD denotes 3
T914 403-404 SYM denotes -
T915 404-405 CD denotes 5
T916 405-406 -RRB- denotes ]
T917 406-407 . denotes .
T918 407-611 sentence denotes Homozygous mutations in man and mouse are lethal and result in severe developmental abnormalities including anophthalmia, severe reduction of the olfactory structures and gross brain malformations [2,6].
T919 408-418 JJ denotes Homozygous
T920 419-428 NNS denotes mutations
T921 446-449 VBP denotes are
T922 429-431 IN denotes in
T923 432-435 NN denotes man
T924 436-439 CC denotes and
T925 440-445 NN denotes mouse
T926 450-456 JJ denotes lethal
T927 457-460 CC denotes and
T928 461-467 VBP denotes result
T929 468-470 IN denotes in
T930 471-477 JJ denotes severe
T931 492-505 NNS denotes abnormalities
T932 478-491 JJ denotes developmental
T933 506-515 VBG denotes including
T934 516-528 NN denotes anophthalmia
T935 528-530 , denotes ,
T936 530-536 JJ denotes severe
T937 537-546 NN denotes reduction
T938 547-549 IN denotes of
T939 550-553 DT denotes the
T940 564-574 NNS denotes structures
T941 554-563 JJ denotes olfactory
T942 575-578 CC denotes and
T943 579-584 JJ denotes gross
T944 591-604 NNS denotes malformations
T945 585-590 NN denotes brain
T946 605-606 -LRB- denotes [
T947 608-609 CD denotes 6
T948 606-607 CD denotes 2
T949 607-608 , denotes ,
T950 609-610 -RRB- denotes ]
T951 610-611 . denotes .
T952 611-929 sentence denotes The roles of PAX6 in brain development have mainly been studied in homozygous mutant mice or rats and include arealisation of the cerebral cortex [7], formation of the prosencephalon-mesencephalon boundary [8], axon guidance [8], differentiation of neurons from glia [9] and neuronal migration in the cerebellum [10].
T953 612-615 DT denotes The
T954 616-621 NNS denotes roles
T955 668-675 VBN denotes studied
T956 622-624 IN denotes of
T957 625-629 NN denotes PAX6
T958 630-632 IN denotes in
T959 633-638 NN denotes brain
T960 639-650 NN denotes development
T961 651-655 VBP denotes have
T962 656-662 RB denotes mainly
T963 663-667 VBN denotes been
T964 676-678 IN denotes in
T965 679-689 JJ denotes homozygous
T966 697-701 NNS denotes mice
T967 690-696 NN denotes mutant
T968 702-704 CC denotes or
T969 705-709 NNS denotes rats
T970 710-713 CC denotes and
T971 714-721 VBP denotes include
T972 722-734 NN denotes arealisation
T973 735-737 IN denotes of
T974 738-741 DT denotes the
T975 751-757 NN denotes cortex
T976 742-750 JJ denotes cerebral
T977 758-759 -LRB- denotes [
T978 759-760 CD denotes 7
T979 760-761 -RRB- denotes ]
T980 761-763 , denotes ,
T981 763-772 NN denotes formation
T982 773-775 IN denotes of
T983 776-779 DT denotes the
T984 809-817 NN denotes boundary
T985 780-794 NN denotes prosencephalon
T986 795-808 NN denotes mesencephalon
T987 794-795 HYPH denotes -
T988 818-819 -LRB- denotes [
T989 819-820 CD denotes 8
T990 820-821 -RRB- denotes ]
T991 821-823 , denotes ,
T992 823-827 NN denotes axon
T993 828-836 NN denotes guidance
T994 837-838 -LRB- denotes [
T995 838-839 CD denotes 8
T996 839-840 -RRB- denotes ]
T997 840-842 , denotes ,
T998 842-857 NN denotes differentiation
T999 858-860 IN denotes of
T1000 861-868 NNS denotes neurons
T1001 869-873 IN denotes from
T1002 874-878 NNS denotes glia
T1003 879-880 -LRB- denotes [
T1004 880-881 CD denotes 9
T1005 881-882 -RRB- denotes ]
T1006 883-886 CC denotes and
T1007 887-895 JJ denotes neuronal
T1008 896-905 NN denotes migration
T1009 906-908 IN denotes in
T1010 909-912 DT denotes the
T1011 913-923 NN denotes cerebellum
T1012 924-925 -LRB- denotes [
T1013 925-927 CD denotes 10
T1014 927-928 -RRB- denotes ]
T1015 928-929 . denotes .
R257 T834 T835 det The,protein
R258 T835 T837 nsubj protein,is
R259 T836 T835 compound PAX6,protein
R260 T838 T839 det a,member
R261 T839 T837 attr member,is
R262 T840 T839 prep of,member
R263 T841 T842 det the,family
R264 T842 T840 pobj family,of
R265 T843 T842 nmod PAX,family
R266 T844 T843 punct (,PAX
R267 T845 T846 amod paired,box
R268 T846 T843 appos box,PAX
R269 T847 T846 punct -,box
R270 T848 T842 punct ),family
R271 T849 T842 prep of,family
R272 T850 T851 amod transcriptional,regulators
R273 T851 T849 pobj regulators,of
R274 T852 T837 cc and,is
R275 T853 T837 conj is,is
R276 T854 T853 acomp essential,is
R277 T855 T854 prep for,essential
R278 T856 T857 amod normal,development
R279 T857 T855 pobj development,for
R280 T858 T857 amod ocular,development
R281 T859 T858 cc and,ocular
R282 T860 T858 conj neural,ocular
R283 T861 T862 punct [,1
R284 T862 T853 parataxis 1,is
R285 T863 T862 punct ],1
R286 T864 T837 punct .,is
R287 T866 T867 amod Heterozygous,mutations
R288 T867 T868 nsubj mutations,cause
R289 T869 T867 prep of,mutations
R290 T870 T871 det the,gene
R291 T871 T869 pobj gene,of
R292 T872 T871 amod human,gene
R293 T873 T871 compound PAX6,gene
R294 T874 T868 dobj aniridia,cause
R295 T875 T874 punct (,aniridia
R296 T876 T874 appos absence,aniridia
R297 T877 T876 prep of,absence
R298 T878 T879 det the,iris
R299 T879 T877 pobj iris,of
R300 T880 T874 punct ),aniridia
R301 T881 T874 cc and,aniridia
R302 T882 T883 det a,range
R303 T883 T874 conj range,aniridia
R304 T884 T883 prep of,range
R305 T885 T886 amod other,malformations
R306 T886 T884 pobj malformations,of
R307 T887 T886 amod congenital,malformations
R308 T888 T886 compound eye,malformations
R309 T889 T890 punct [,2
R310 T890 T868 parataxis 2,cause
R311 T891 T890 punct ],2
R312 T892 T868 punct .,cause
R313 T894 T895 amod Neural,defects
R314 T895 T896 nsubj defects,are
R315 T897 T898 amod such,as
R316 T898 T895 prep as,defects
R317 T899 T900 amod foveal,hypoplasia
R318 T900 T898 pobj hypoplasia,as
R319 T901 T900 cc and,hypoplasia
R320 T902 T903 amod optic,nerve
R321 T903 T904 compound nerve,hypoplasia
R322 T904 T900 conj hypoplasia,hypoplasia
R323 T905 T896 acomp common,are
R324 T906 T896 prep in,are
R325 T907 T908 npadvmod PAX6,associated
R326 T908 T910 amod associated,disease
R327 T909 T908 punct -,associated
R328 T910 T906 pobj disease,in
R329 T911 T910 compound eye,disease
R330 T912 T913 punct [,3
R331 T913 T896 parataxis 3,are
R332 T914 T915 punct -,5
R333 T915 T913 prep 5,3
R334 T916 T913 punct ],3
R335 T917 T896 punct .,are
R336 T919 T920 amod Homozygous,mutations
R337 T920 T921 nsubj mutations,are
R338 T922 T920 prep in,mutations
R339 T923 T922 pobj man,in
R340 T924 T923 cc and,man
R341 T925 T923 conj mouse,man
R342 T926 T921 acomp lethal,are
R343 T927 T921 cc and,are
R344 T928 T921 conj result,are
R345 T929 T928 prep in,result
R346 T930 T931 amod severe,abnormalities
R347 T931 T929 pobj abnormalities,in
R348 T932 T931 amod developmental,abnormalities
R349 T933 T931 prep including,abnormalities
R350 T934 T933 pobj anophthalmia,including
R351 T935 T934 punct ", ",anophthalmia
R352 T936 T937 amod severe,reduction
R353 T937 T934 conj reduction,anophthalmia
R354 T938 T937 prep of,reduction
R355 T939 T940 det the,structures
R356 T940 T938 pobj structures,of
R357 T941 T940 amod olfactory,structures
R358 T942 T937 cc and,reduction
R359 T943 T944 amod gross,malformations
R360 T944 T937 conj malformations,reduction
R361 T945 T944 compound brain,malformations
R362 T946 T947 punct [,6
R363 T947 T928 parataxis 6,result
R364 T948 T947 nummod 2,6
R365 T949 T947 punct ",",6
R366 T950 T947 punct ],6
R367 T951 T921 punct .,are
R368 T953 T954 det The,roles
R369 T954 T955 nsubjpass roles,studied
R370 T956 T954 prep of,roles
R371 T957 T956 pobj PAX6,of
R372 T958 T954 prep in,roles
R373 T959 T960 compound brain,development
R374 T960 T958 pobj development,in
R375 T961 T955 aux have,studied
R376 T962 T955 advmod mainly,studied
R377 T963 T955 auxpass been,studied
R378 T964 T955 prep in,studied
R379 T965 T966 amod homozygous,mice
R380 T966 T964 pobj mice,in
R381 T967 T966 compound mutant,mice
R382 T968 T966 cc or,mice
R383 T969 T966 conj rats,mice
R384 T970 T955 cc and,studied
R385 T971 T955 conj include,studied
R386 T972 T971 dobj arealisation,include
R387 T973 T972 prep of,arealisation
R388 T974 T975 det the,cortex
R389 T975 T973 pobj cortex,of
R390 T976 T975 amod cerebral,cortex
R391 T977 T978 punct [,7
R392 T978 T972 parataxis 7,arealisation
R393 T979 T978 punct ],7
R394 T980 T972 punct ", ",arealisation
R395 T981 T972 conj formation,arealisation
R396 T982 T981 prep of,formation
R397 T983 T984 det the,boundary
R398 T984 T982 pobj boundary,of
R399 T985 T986 compound prosencephalon,mesencephalon
R400 T986 T984 compound mesencephalon,boundary
R401 T987 T986 punct -,mesencephalon
R402 T988 T989 punct [,8
R403 T989 T981 parataxis 8,formation
R404 T990 T989 punct ],8
R405 T991 T981 punct ", ",formation
R406 T992 T993 compound axon,guidance
R407 T993 T981 conj guidance,formation
R408 T994 T995 punct [,8
R409 T995 T993 parataxis 8,guidance
R410 T996 T995 punct ],8
R411 T997 T993 punct ", ",guidance
R412 T998 T993 conj differentiation,guidance
R413 T999 T998 prep of,differentiation
R414 T1000 T999 pobj neurons,of
R415 T1001 T998 prep from,differentiation
R416 T1002 T1001 pobj glia,from
R417 T1003 T1004 punct [,9
R418 T1004 T998 parataxis 9,differentiation
R419 T1005 T1004 punct ],9
R420 T1006 T998 cc and,differentiation
R421 T1007 T1008 amod neuronal,migration
R422 T1008 T998 conj migration,differentiation
R423 T1009 T1008 prep in,migration
R424 T1010 T1011 det the,cerebellum
R425 T1011 T1009 pobj cerebellum,in
R426 T1012 T1013 punct [,10
R427 T1013 T1008 parataxis 10,migration
R428 T1014 T1013 punct ],10
R429 T1015 T955 punct .,studied

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T665 4-8 PR_EXT:000012318 denotes PAX6
T666 9-16 CHEBI_PR_EXT:protein denotes protein
T667 36-39 PR_EXT:000037797 denotes PAX
T668 41-51 PR_EXT:000037797 denotes paired-box
T669 63-78 GO_EXT:transcription denotes transcriptional
T670 79-89 GO_EXT:regulator denotes regulators
T671 118-124 UBERON:0000970 denotes ocular
T672 118-124 _FRAGMENT denotes ocular
T673 136-147 GO:0001654 denotes development
T674 129-135 UBERON_EXT:neural_tissue_or_nerve_or_nervous_system denotes neural
T675 129-147 GO:0007399 denotes neural development
T676 166-175 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T677 183-188 NCBITaxon:9606 denotes human
T678 189-193 PR_EXT:000012318 denotes PAX6
T679 194-198 SO_EXT:0000704 denotes gene
T680 230-234 UBERON:0001769 denotes iris
T681 268-271 UBERON:0000970 denotes eye
T682 291-297 UBERON_EXT:neural_tissue_or_nerve_or_nervous_system denotes Neural
T683 314-320 UBERON:0001786 denotes foveal
T684 336-347 UBERON_EXT:optic_nerve denotes optic nerve
T685 373-377 PR_EXT:000012318 denotes PAX6
T686 389-392 UBERON:0000970 denotes eye
T687 419-428 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T688 432-435 NCBITaxon:9606 denotes man
T689 440-445 NCBITaxon:10088 denotes mouse
T690 450-456 GO_EXT:fatality_or_lethality denotes lethal
T691 554-563 GO:0007608 denotes olfactory
T692 585-590 UBERON:0000955 denotes brain
T693 625-629 PR_EXT:000012318 denotes PAX6
T694 633-638 UBERON:0000955 denotes brain
T695 633-650 GO:0007420 denotes brain development
T696 690-696 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T697 697-701 NCBITaxon:10088 denotes mice
T698 705-709 NCBITaxon:10114 denotes rats
T699 742-757 UBERON:0000956 denotes cerebral cortex
T700 763-775 _FRAGMENT denotes formation of
T701 780-817 GO:0021905 denotes prosencephalon-mesencephalon boundary
T702 780-794 UBERON:0001890 denotes prosencephalon
T703 795-808 UBERON:0001891 denotes mesencephalon
T704 823-827 GO:0030424 denotes axon
T705 823-836 GO:0007411 denotes axon guidance
T706 842-857 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T707 861-868 CL:0000540 denotes neurons
T708 874-878 CL:0000125 denotes glia
T709 887-895 CL:0000540 denotes neuronal
T710 887-905 GO:0001764 denotes neuronal migration
T711 913-923 UBERON:0002037 denotes cerebellum
R254 T673 T672 _lexicallyChainedTo development,ocular
R255 T701 T700 _lexicallyChainedTo prosencephalon-mesencephalon boundary,formation of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T550 4-8 PR:000012318 denotes PAX6
T551 36-39 PR:000037797 denotes PAX
T552 41-51 PR:000037797 denotes paired-box
T553 118-124 UBERON:0000970 denotes ocular
T554 118-124 _FRAGMENT denotes ocular
T555 136-147 GO:0001654 denotes development
T556 129-147 GO:0007399 denotes neural development
T557 183-188 NCBITaxon:9606 denotes human
T558 189-193 PR:000012318 denotes PAX6
T559 194-198 SO:0000704 denotes gene
T560 230-234 UBERON:0001769 denotes iris
T561 268-271 UBERON:0000970 denotes eye
T562 314-320 UBERON:0001786 denotes foveal
T563 336-341 UBERON:0000970 denotes optic
T564 373-377 PR:000012318 denotes PAX6
T565 389-392 UBERON:0000970 denotes eye
T566 432-435 NCBITaxon:9606 denotes man
T567 440-445 NCBITaxon:10088 denotes mouse
T568 554-563 GO:0007608 denotes olfactory
T569 585-590 UBERON:0000955 denotes brain
T570 625-629 PR:000012318 denotes PAX6
T571 633-638 UBERON:0000955 denotes brain
T572 633-650 GO:0007420 denotes brain development
T573 697-701 NCBITaxon:10088 denotes mice
T574 705-709 NCBITaxon:10114 denotes rats
T575 742-757 UBERON:0000956 denotes cerebral cortex
T576 763-775 _FRAGMENT denotes formation of
T577 780-817 GO:0021905 denotes prosencephalon-mesencephalon boundary
T578 780-794 UBERON:0001890 denotes prosencephalon
T579 795-808 UBERON:0001891 denotes mesencephalon
T581 823-836 GO:0007411 denotes axon guidance
T582 861-868 CL:0000540 denotes neurons
T583 874-878 CL:0000125 denotes glia
T584 887-895 CL:0000540 denotes neuronal
T585 887-905 GO:0001764 denotes neuronal migration
T586 913-923 UBERON:0002037 denotes cerebellum
T580 823-827 GO:0030424 denotes axon
R251 T555 T554 _lexicallyChainedTo development,ocular
R252 T577 T576 _lexicallyChainedTo prosencephalon-mesencephalon boundary,formation of