PMC:1208879 / 1518-31446 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T8267	29526-29527	.	denotes	.
T8266	29525-29526	-RRB-	denotes	)
T8265	29518-29525	NNP	denotes	Promega
T8264	29517-29518	-LRB-	denotes	(
T8263	29504-29508	NN	denotes	size
T8262	29509-29516	NNS	denotes	markers
T8261	29496-29497	HYPH	denotes	/
T8260	29497-29503	NN	denotes	HaeIII
T8259	29491-29496	NN	denotes	ΦX174
T8258	29486-29490	IN	denotes	with
T8257	29474-29481	NN	denotes	agarose
T8256	29472-29473	NN	denotes	%
T8255	29469-29472	CD	denotes	2.5
T8254	29482-29485	NN	denotes	gel
T8253	29467-29468	DT	denotes	a
T8252	29464-29466	IN	denotes	on
T8251	29450-29454	VBD	denotes	were
T8250	29455-29463	VBN	denotes	resolved
T8249	29441-29449	NNS	denotes	Products
T8248	29440-29527	sentence	denotes	Products were resolved on a 2.5% agarose gel with ΦX174/HaeIII size markers (Promega).
T8247	29439-29440	.	denotes	.
T8246	29438-29439	CD	denotes	1
T8245	29436-29437	SYM	denotes	×
T8244	29434-29435	-RRB-	denotes	)
T8243	29431-29434	NN	denotes	min
T8242	29429-29430	CD	denotes	2
T8241	29425-29428	IN	denotes	for
T8240	29420-29422	CD	denotes	72
T8239	29422-29424	NN	denotes	°C
T8238	29419-29420	-LRB-	denotes	(
T8237	29415-29418	CC	denotes	and
T8236	29412-29414	CD	denotes	32
T8235	29410-29411	SYM	denotes	×
T8234	29408-29409	-RRB-	denotes	)
T8233	29405-29408	NN	denotes	sec
T8232	29402-29404	CD	denotes	30
T8231	29398-29401	IN	denotes	for
T8230	29395-29397	NN	denotes	°C
T8229	29393-29395	CD	denotes	72
T8228	29391-29393	,	denotes	,
T8227	29388-29391	NN	denotes	sec
T8226	29385-29387	CD	denotes	30
T8225	29381-29384	IN	denotes	for
T8224	29378-29380	NN	denotes	°C
T8223	29376-29378	CD	denotes	55
T8222	29374-29376	,	denotes	,
T8221	29371-29374	NN	denotes	sec
T8220	29368-29370	CD	denotes	30
T8219	29364-29367	IN	denotes	for
T8218	29359-29361	CD	denotes	94
T8217	29361-29363	NN	denotes	°C
T8216	29358-29359	-LRB-	denotes	(
T8215	29356-29358	,	denotes	,
T8214	29355-29356	CD	denotes	1
T8213	29353-29354	SYM	denotes	×
T8212	29351-29352	-RRB-	denotes	)
T8211	29348-29351	NN	denotes	sec
T8210	29345-29347	CD	denotes	30
T8209	29341-29344	IN	denotes	for
T8208	29338-29340	NN	denotes	°C
T8207	29336-29338	CD	denotes	95
T8206	29335-29336	-LRB-	denotes	(
T8205	29330-29334	VBD	denotes	were
T8204	29319-29329	NNS	denotes	conditions
T8203	29315-29318	NN	denotes	PCR
T8202	29314-29440	sentence	denotes	PCR conditions were (95°C for 30 sec) × 1, (94°C for 30 sec, 55°C for 30 sec, 72°C for 30 sec) × 32 and (72°C for 2 min) × 1.
T8201	29313-29314	.	denotes	.
T8200	29312-29313	-RRB-	denotes	)
T8199	29300-29306	NNP	denotes	Perkin
T8198	29307-29312	NNP	denotes	Elmer
T8197	29299-29300	-LRB-	denotes	(
T8196	29288-29298	NN	denotes	polymerase
T8195	29279-29287	NNP	denotes	AmpliTaq
T8194	29276-29278	IN	denotes	of
T8193	29270-29275	NNS	denotes	units
T8192	29266-29269	CD	denotes	2.5
T8191	29262-29265	CC	denotes	and
T8190	29250-29254	DT	denotes	each
T8189	29255-29261	NN	denotes	primer
T8188	29244-29249	NN	denotes	200μM
T8187	29242-29244	,	denotes	,
T8186	29237-29242	NN	denotes	MgCl2
T8185	29234-29236	NN	denotes	mM
T8184	29230-29233	CD	denotes	1.5
T8183	29228-29230	,	denotes	,
T8182	29227-29228	-RRB-	denotes	)
T8181	29215-29221	NNP	denotes	Perkin
T8180	29222-29227	NNP	denotes	Elmer
T8179	29214-29215	-LRB-	denotes	(
T8178	29196-29206	NN	denotes	polymerase
T8177	29187-29195	NNP	denotes	AmpliTaq
T8176	29186-29187	SYM	denotes	x
T8175	29207-29213	NN	denotes	buffer
T8174	29185-29186	CD	denotes	1
T8173	29174-29184	VBG	denotes	containing
T8172	29165-29173	NN	denotes	reaction
T8171	29163-29164	DT	denotes	a
T8170	29160-29162	IN	denotes	in
T8169	29145-29149	VBD	denotes	were
T8168	29150-29159	VBN	denotes	amplified
T8167	29132-29139	NN	denotes	library
T8166	29140-29144	NN	denotes	cDNA
T8165	29129-29131	NN	denotes	ng
T8164	29126-29128	CD	denotes	10
T8163	29125-29314	sentence	denotes	10 ng library cDNA were amplified in a reaction containing 1xAmpliTaq polymerase buffer (Perkin Elmer), 1.5 mM MgCl2, 200μM each primer and 2.5 units of AmpliTaq polymerase (Perkin Elmer).
T8162	29124-29125	.	denotes	.
T8161	29119-29122	NN	denotes	ATA
T8160	29115-29118	NN	denotes	GGG
T8159	29111-29114	NN	denotes	TCG
T8158	29107-29110	NN	denotes	GAT
T8157	29103-29106	NN	denotes	AGA
T8156	29123-29124	NN	denotes	A
T8155	29099-29102	NN	denotes	CAC
T8154	29097-29099	:	denotes	:
T8153	29095-29096	HYPH	denotes	-
T8152	29096-29097	NN	denotes	R
T8151	29089-29095	NN	denotes	Atp5a1
T8150	29087-29088	:	denotes	;
T8149	29081-29084	NN	denotes	CTC
T8148	29077-29080	NN	denotes	GTC
T8147	29073-29076	NN	denotes	GAT
T8146	29069-29072	NN	denotes	TGA
T8145	29065-29068	NN	denotes	ACG
T8144	29085-29087	NN	denotes	CA
T8143	29061-29064	NN	denotes	CAC
T8142	29059-29061	:	denotes	:
T8141	29057-29058	HYPH	denotes	-
T8140	29058-29059	NN	denotes	F
T8139	29051-29057	NN	denotes	Atp5a1
T8138	29049-29050	:	denotes	;
T8137	29043-29046	NN	denotes	GCC
T8136	29039-29042	NN	denotes	ACA
T8135	29035-29038	NN	denotes	CCC
T8134	29031-29034	NN	denotes	TTG
T8133	29027-29030	NN	denotes	ACC
T8132	29047-29049	NN	denotes	TT
T8131	29023-29026	NN	denotes	ATG
T8130	29021-29023	:	denotes	:
T8120	29010-29012	NN	denotes	GC
T8119	28986-28989	NN	denotes	CAT
T8118	28984-28986	:	denotes	:
T8117	28982-28983	HYPH	denotes	-
T8116	28983-28984	NN	denotes	F
T8115	28977-28982	NN	denotes	Gapdh
T8114	28975-28976	:	denotes	;
T8113	28968-28971	NN	denotes	ATG
T8112	28964-28967	NN	denotes	AAA
T8111	28960-28963	NN	denotes	AAA
T8110	28956-28959	NN	denotes	GAG
T8109	28952-28955	NN	denotes	AGG
T8108	28948-28951	NN	denotes	CTA
T8107	28972-28975	NN	denotes	GGG
T8106	28946-28947	NN	denotes	R
T8105	28945-28946	HYPH	denotes	-
T8104	28940-28945	NN	denotes	Dncl1
T8103	28938-28939	:	denotes	;
T8102	28933-28936	NNP	denotes	GTC
T8101	28929-28932	NNP	denotes	CAT
T8100	28925-28928	NNP	denotes	AGA
T8099	28921-28924	NN	denotes	TGC
T8098	28917-28920	NN	denotes	AAA
T8097	28913-28916	NN	denotes	CAA
T8096	28937-28938	NN	denotes	G
T8095	28911-28912	NN	denotes	F
T8094	28910-28911	HYPH	denotes	-
T8093	28905-28910	NN	denotes	Dncl1
T8092	28903-28904	:	denotes	;
T8091	28897-28900	NN	denotes	TAG
T8090	28893-28896	NN	denotes	TCA
T8089	28889-28892	NN	denotes	TAG
T8088	28885-28888	NN	denotes	AGA
T8087	28881-28884	NN	denotes	TGC
T8086	28877-28880	NN	denotes	GCC
T8085	28901-28903	NN	denotes	GG
T8084	28875-28876	NN	denotes	R
T8083	28874-28875	HYPH	denotes	-
T8082	28868-28874	NN	denotes	Trim11
T8081	28866-28867	:	denotes	;
T8080	28859-28862	NN	denotes	AAG
T8079	28855-28858	NN	denotes	GTG
T8078	28851-28854	NN	denotes	GAT
T8077	28847-28850	NN	denotes	CAG
T8076	28843-28846	NN	denotes	GTG
T8075	28863-28866	NN	denotes	CTG
T8074	28841-28842	NN	denotes	F
T8073	28840-28841	HYPH	denotes	-
T8072	28834-28840	NN	denotes	Trim11
T8071	28832-28833	:	denotes	;
T8070	28827-28830	NN	denotes	TCA
T8069	28823-28826	NN	denotes	AGC
T8068	28819-28822	NN	denotes	CAA
T8067	28815-28818	NN	denotes	GTG
T8066	28811-28814	NN	denotes	ACA
T8065	28807-28810	NN	denotes	TAC
T8064	28803-28806	NN	denotes	CTC
T8063	28831-28832	NN	denotes	G
T8062	28801-28802	NN	denotes	R
T8061	28800-28801	HYPH	denotes	-
T8060	28794-28800	NN	denotes	Homer3
T8059	28792-28793	:	denotes	;
T8058	28785-28788	NN	denotes	TAG
T8057	28781-28784	NN	denotes	CTG
T8056	28777-28780	NN	denotes	TGG
T8055	28773-28776	NN	denotes	AGG
T8054	28769-28772	NN	denotes	CCC
T8053	28789-28792	NN	denotes	AGC
T8052	28767-28768	NN	denotes	F
T8051	28766-28767	HYPH	denotes	-
T8050	28760-28766	NN	denotes	Homer3
T8049	28758-28759	:	denotes	;
T8048	28752-28755	NN	denotes	TCC
T8047	28748-28751	NN	denotes	CTC
T8046	28744-28747	NN	denotes	GCT
T8045	28740-28743	NN	denotes	CAT
T8044	28736-28739	NN	denotes	TCA
T8043	28732-28735	NN	denotes	CGA
T8042	28756-28758	NN	denotes	TT
T8041	28730-28731	NN	denotes	R
T8040	28729-28730	HYPH	denotes	-
T8039	28725-28729	NN	denotes	Pax6
T8038	28723-28724	:	denotes	;
T8037	28716-28719	NN	denotes	TAC
T8036	28712-28715	NN	denotes	ATC
T8035	28708-28711	NN	denotes	TAG
T8034	28704-28707	NN	denotes	AAA
T8033	28700-28703	NN	denotes	CCA
T8032	28696-28699	NN	denotes	CAG
T8031	28720-28723	NN	denotes	CTG
T8030	28694-28695	NN	denotes	F
T8029	28693-28694	HYPH	denotes	-
T8028	28689-28693	NN	denotes	Pax6
T8027	28687-28689	:	denotes	:
T8026	28683-28687	VBD	denotes	were
T8025	28673-28682	NNS	denotes	sequences
T8024	28666-28672	NN	denotes	Primer
T8023	28665-29125	sentence	denotes	Primer sequences were: Pax6-F CAG CCA AAA TAG ATC TAC CTG; Pax6-R CGA TCA CAT GCT CTC TCC TT; Homer3-F CCC AGG TGG CTG TAG AGC; Homer3-R CTC TAC ACA GTG CAA AGC TCA G; Trim11-F GTG CAG GAT GTG AAG CTG; Trim11-R GCC TGC AGA TAG TCA TAG GG; Dncl1-F CAA AAA TGC AGA CAT GTC G; Dncl1-R CTA AGG GAG AAA AAA ATG GGG; Gapdh-F: CAT CAC CAT CTT CCA GGA GC; Gapdh-R: ATG ACC TTG CCC ACA GCC TT; Atp5a1-F: CAC ACG TGA GAT GTC CTC CA; Atp5a1-R: CAC AGA GAT TCG GGG ATA A.
T8022	28664-28665	.	denotes	.
T8021	28650-28654	VBD	denotes	were
T8020	28635-28642	VBN	denotes	spliced
T8019	28625-28634	RB	denotes	correctly
T8018	28643-28649	NNS	denotes	clones
T8017	28620-28624	RB	denotes	only
T8016	28615-28619	IN	denotes	that
T8015	28655-28664	VBN	denotes	amplified
T8014	28612-28614	IN	denotes	so
T8013	28610-28612	,	denotes	,
T8012	28604-28610	NN	denotes	intron
T8011	28594-28599	RBS	denotes	least
T8010	28600-28603	CD	denotes	one
T8009	28591-28593	RB	denotes	at
T8008	28585-28590	VB	denotes	cross
T8007	28582-28584	TO	denotes	to
T8006	28568-28572	VBD	denotes	were
T8005	28573-28581	VBN	denotes	designed
T8004	28560-28567	NNS	denotes	Primers
T8003	28559-28665	sentence	denotes	Primers were designed to cross at least one intron, so that only correctly spliced clones were amplified.
T8002	28558-28559	.	denotes	.
T8001	28557-28558	-RRB-	denotes	]
T8000	28554-28555	,	denotes	,
T7999	28552-28554	CD	denotes	29
T7998	28555-28557	CD	denotes	30
T7997	28551-28552	-LRB-	denotes	[
T7996	28544-28550	NN	denotes	Atp5a1
T7995	28540-28543	CC	denotes	and
T7994	28534-28539	NN	denotes	Gapdh
T7993	28518-28527	VBN	denotes	expressed
T7992	28503-28517	RB	denotes	constitutively
T7991	28528-28533	NNS	denotes	genes
T7990	28499-28502	DT	denotes	the
T7989	28495-28498	CC	denotes	and
T7988	28488-28494	NN	denotes	Trim11
T7987	28486-28488	,	denotes	,
T7986	28481-28486	NN	denotes	Dncl1
T7985	28479-28481	,	denotes	,
T7984	28473-28479	NN	denotes	Homer3
T7983	28471-28473	,	denotes	,
T7982	28467-28471	NN	denotes	Pax6
T7981	28464-28466	IN	denotes	on
T7980	28450-28453	VBD	denotes	was
T7979	28446-28449	NN	denotes	PCR
T7978	28428-28445	JJ	denotes	semi-quantitative
T7977	28426-28428	,	denotes	,
T7976	28414-28418	NN	denotes	cDNA
T7975	28419-28426	NN	denotes	library
T7974	28410-28413	DT	denotes	the
T7973	28407-28409	IN	denotes	in
T7972	28400-28406	NNS	denotes	clones
T7971	28397-28399	IN	denotes	of
T7970	28373-28381	JJ	denotes	relative
T7969	28382-28396	NN	denotes	representation
T7968	28369-28372	DT	denotes	the
T7967	28454-28463	VBN	denotes	performed
T7966	28363-28368	VB	denotes	check
T7965	28360-28362	TO	denotes	To
T7964	28359-28559	sentence	denotes	To check the relative representation of clones in the cDNA library, semi-quantitative PCR was performed on Pax6, Homer3, Dncl1, Trim11 and the constitutively expressed genes Gapdh and Atp5a1 [29,30].
T7963	28356-28359	NN	denotes	PCR
T7962	28338-28355	JJ	denotes	Semi-quantitative
T7843	28335-28336	.	denotes	.
T7842	28315-28325	NN	denotes	expression
T7841	28307-28308	HYPH	denotes	-
T7840	28308-28314	NN	denotes	length
T7839	28303-28307	JJ	denotes	full
T7838	28326-28335	NN	denotes	construct
T7837	28301-28302	DT	denotes	a
T7836	28294-28300	VB	denotes	create
T7835	28291-28293	TO	denotes	to
T7834	28275-28276	HYPH	denotes	-
T7833	28276-28282	NN	denotes	Homer3
T7832	28270-28275	NN	denotes	pPC86
T7831	28283-28290	NN	denotes	plasmid
T7830	28266-28269	DT	denotes	the
T7829	28261-28265	IN	denotes	into
T7828	28252-28260	VBN	denotes	inserted
T7827	28248-28251	CC	denotes	and
T7826	28244-28247	NN	denotes	PCR
T7825	28241-28243	IN	denotes	by
T7824	28229-28234	NN	denotes	IMAGE
T7823	28235-28240	NN	denotes	clone
T7822	28225-28228	DT	denotes	the
T7821	28220-28224	IN	denotes	from
T7820	28206-28209	VBD	denotes	was
T7819	28210-28219	VBN	denotes	amplified
T7818	28189-28196	JJ	denotes	missing
T7817	28197-28205	NN	denotes	fragment
T7816	28185-28188	DT	denotes	The
T7815	28184-28336	sentence	denotes	The missing fragment was amplified from the IMAGE clone by PCR and inserted into the pPC86-Homer3 plasmid to create a full-length expression construct.
T7814	28183-28184	.	denotes	.
T7813	28175-28183	NNP	denotes	Research
T7812	28166-28174	NNP	denotes	Genomics
T7811	28162-28165	IN	denotes	for
T7810	28146-28154	NNP	denotes	Franklin
T7809	28137-28145	NNP	denotes	Rosalind
T7808	28155-28161	NNP	denotes	Centre
T7807	28133-28136	DT	denotes	the
T7806	28128-28132	IN	denotes	from
T7805	28119-28127	VBN	denotes	obtained
T7804	28115-28118	CC	denotes	and
T7803	28097-28105	NN	denotes	sequence
T7802	28086-28096	NN	denotes	nucleotide
T7801	28082-28085	NN	denotes	EST
T7800	28106-28114	NN	denotes	database
T7799	28078-28081	DT	denotes	the
T7798	28075-28077	IN	denotes	of
T7797	28062-28067	NNP	denotes	BLAST
T7796	28068-28074	NN	denotes	search
T7795	28060-28061	DT	denotes	a
T7794	28057-28059	IN	denotes	by
T7793	28042-28045	VBD	denotes	was
T7792	28030-28035	NN	denotes	amino
T7791	28027-28029	CD	denotes	70
T7790	28017-28018	HYPH	denotes	-
T7789	28018-28026	JJ	denotes	terminal
T7788	28016-28017	NN	denotes	N
T7787	28008-28015	JJ	denotes	missing
T7786	28036-28041	NNS	denotes	acids
T7785	28004-28007	DT	denotes	the
T7784	27993-28003	VBG	denotes	containing
T7783	27991-27992	-RRB-	denotes	)
T7782	27976-27982	NN	denotes	number
T7781	27983-27991	NN	denotes	BE569374
T7780	27966-27975	NN	denotes	accession
T7779	27964-27966	,	denotes	,
T7778	27957-27964	CD	denotes	3602414
T8129	29019-29020	HYPH	denotes	-
T8128	29020-29021	NN	denotes	R
T8127	29014-29019	NN	denotes	Gapdh
T8126	29012-29013	:	denotes	;
T8125	29006-29009	NN	denotes	GGA
T8124	29002-29005	NN	denotes	CCA
T8123	28998-29001	NN	denotes	CTT
T8122	28994-28997	NN	denotes	CAT
T8121	28990-28993	NN	denotes	CAC
T7777	27945-27950	NN	denotes	IMAGE
T7776	27951-27956	NN	denotes	clone
T7775	27944-27945	-LRB-	denotes	(
T7774	27933-27937	NN	denotes	cDNA
T7773	27938-27943	NN	denotes	clone
T7772	27931-27932	DT	denotes	a
T7771	27929-27931	,	denotes	,
T7770	27924-27929	NNS	denotes	tests
T7769	27915-27923	JJ	denotes	pairwise
T7768	27911-27914	IN	denotes	for
T7767	27898-27904	NN	denotes	Homer3
T7766	27890-27891	HYPH	denotes	-
T7765	27891-27897	NN	denotes	length
T7764	27886-27890	JJ	denotes	full
T7763	27905-27910	NN	denotes	clone
T7762	27884-27885	DT	denotes	a
T7761	28046-28056	VBN	denotes	identified
T7760	27877-27883	VB	denotes	create
T7759	27874-27876	TO	denotes	To
T7758	27873-28184	sentence	denotes	To create a full-length Homer3 clone for pairwise tests, a cDNA clone (IMAGE clone 3602414, accession number BE569374) containing the missing N-terminal 70 amino acids was identified by a BLAST search of the EST nucleotide sequence database and obtained from the Rosalind Franklin Centre for Genomics Research.
T7757	27872-27873	.	denotes	.
T7756	27866-27872	RB	denotes	before
T7755	27863-27865	IN	denotes	as
T7754	27848-27852	NN	denotes	LacZ
T7753	27844-27847	CC	denotes	and
T7752	27839-27843	NN	denotes	URA3
T7751	27837-27839	,	denotes	,
T7750	27833-27837	NN	denotes	HIS3
T7749	27853-27862	NNS	denotes	reporters
T7748	27829-27832	DT	denotes	the
T7747	27826-27828	IN	denotes	of
T7746	27815-27825	NN	denotes	activation
T7745	27811-27814	IN	denotes	for
T7744	27792-27801	VBG	denotes	resulting
T7743	27802-27810	NNS	denotes	colonies
T7742	27788-27791	DT	denotes	the
T7741	27780-27787	VBG	denotes	testing
T7740	27776-27779	CC	denotes	and
T7739	27774-27775	-RRB-	denotes	)
T7738	27769-27774	NN	denotes	pPC86
T7737	27766-27768	IN	denotes	in
T7736	27765-27766	-LRB-	denotes	(
T7735	27755-27764	NN	denotes	construct
T7734	27750-27754	NN	denotes	prey
T7733	27746-27749	CD	denotes	one
T7732	27742-27745	CC	denotes	and
T7731	27740-27741	-RRB-	denotes	)
T7730	27734-27740	NN	denotes	pDBLeu
T7729	27731-27733	IN	denotes	in
T7728	27730-27731	-LRB-	denotes	(
T7727	27720-27729	NN	denotes	construct
T7726	27715-27719	NN	denotes	bait
T7725	27711-27714	CD	denotes	one
T7724	27706-27710	IN	denotes	with
T7723	27694-27699	NN	denotes	yeast
T7722	27687-27693	NN	denotes	MaV203
T7721	27700-27705	NNS	denotes	cells
T7720	27677-27686	JJ	denotes	competent
T7719	27664-27676	VBG	denotes	transforming
T7718	27661-27663	IN	denotes	by
T7717	27649-27653	VBD	denotes	were
T7716	27654-27660	VBN	denotes	tested
T7715	27636-27648	NNS	denotes	interactions
T7714	27627-27635	JJ	denotes	Specific
T7713	27626-27873	sentence	denotes	Specific interactions were tested by transforming competent MaV203 yeast cells with one bait construct (in pDBLeu) and one prey construct (in pPC86) and testing the resulting colonies for activation of the HIS3, URA3 and LacZ reporters as before.
T7712	27614-27626	NNS	denotes	interactions
T7711	27605-27613	JJ	denotes	Pairwise
T7663	27602-27603	.	denotes	.
T7662	27601-27602	-RRB-	denotes	]
T7661	27599-27601	CD	denotes	24
T7660	27598-27599	-LRB-	denotes	[
T7659	27586-27590	NN	denotes	cDNA
T7486	26698-26848	sentence	denotes	Weak URA3 activation suppresses growth on plates containing 5-fluro-orotic acid while strong URA3 activation permits growth on plates lacking uracil.
T7485	26697-26698	.	denotes	.
T7484	26688-26697	NN	denotes	histidine
T7483	26680-26687	VBG	denotes	lacking
T7482	26673-26679	NNS	denotes	plates
T7481	26670-26672	IN	denotes	on
T7480	26663-26669	NN	denotes	growth
T7479	26656-26662	VBZ	denotes	allows
T7478	26645-26655	NN	denotes	activation
T7477	26640-26644	NN	denotes	HIS3
T7476	26639-26698	sentence	denotes	HIS3 activation allows growth on plates lacking histidine.
T7475	26638-26639	.	denotes	.
T7474	26630-26638	NN	denotes	function
T7473	26625-26629	NN	denotes	GAL4
T7472	26610-26624	VBG	denotes	reconstituting
T7471	26605-26609	RB	denotes	thus
T7470	26603-26605	,	denotes	,
T7469	26602-26603	-RRB-	denotes	)
T7468	26597-26602	NN	denotes	pPC86
T7467	26596-26597	-LRB-	denotes	(
T7466	26578-26588	NN	denotes	activation
T7465	26573-26577	NN	denotes	GAL4
T7464	26589-26595	NN	denotes	domain
T7463	26569-26572	DT	denotes	the
T7462	26566-26568	IN	denotes	to
T7461	26560-26565	VBN	denotes	fused
T7460	26547-26551	NN	denotes	prey
T7459	26552-26559	NN	denotes	protein
T7458	26543-26546	DT	denotes	the
T7457	26538-26542	IN	denotes	with
T7456	26526-26527	-RRB-	denotes	)
T7455	26520-26526	NN	denotes	pDBLeu
T7454	26519-26520	-LRB-	denotes	(
T7453	26504-26511	NN	denotes	binding
T7452	26500-26503	NN	denotes	DNA
T7451	26495-26499	NN	denotes	GAL4
T7450	26512-26518	NN	denotes	domain
T7449	26491-26494	DT	denotes	the
T7448	26488-26490	IN	denotes	to
T7447	26482-26487	VBN	denotes	fused
T7446	26469-26473	NN	denotes	bait
T7445	26474-26481	NN	denotes	protein
T7444	26465-26468	DT	denotes	the
T7443	26528-26537	VBZ	denotes	interacts
T7442	26460-26464	WRB	denotes	when
T7441	26446-26449	VBP	denotes	are
T7440	26450-26459	VBN	denotes	activated
T7439	26436-26445	NNS	denotes	Reporters
T7438	26435-26639	sentence	denotes	Reporters are activated when the bait protein fused to the GAL4 DNA binding domain (pDBLeu) interacts with the prey protein fused to the GAL4 activation domain (pPC86), thus reconstituting GAL4 function.
T7437	26434-26435	.	denotes	.
T7436	26422-26434	NNS	denotes	interactions
T7435	26413-26421	JJ	denotes	positive
T7434	26404-26412	VB	denotes	identify
T7433	26401-26403	TO	denotes	to
T7432	26399-26401	,	denotes	,
T7431	26395-26399	NN	denotes	lacZ
T7430	26391-26394	CC	denotes	and
T7429	26386-26390	NN	denotes	URA3
T7428	26384-26386	,	denotes	,
T7427	26380-26384	NN	denotes	HIS3
T7426	26378-26380	,	denotes	,
T7425	26364-26372	NN	denotes	reporter
T7424	26353-26354	HYPH	denotes	-
T7423	26354-26363	VBN	denotes	activated
T7422	26349-26353	NN	denotes	GAL4
T7421	26373-26378	NNS	denotes	genes
T7420	26343-26348	CD	denotes	three
T7419	26338-26342	VBZ	denotes	uses
T7418	26331-26337	NN	denotes	system
T7417	26327-26330	DT	denotes	The
T7416	26326-26435	sentence	denotes	The system uses three GAL4-activated reporter genes, HIS3, URA3 and lacZ, to identify positive interactions.
T7415	26325-26326	.	denotes	.
T7414	26308-26318	NN	denotes	activation
T7413	26303-26307	NN	denotes	GAL4
T7412	26297-26302	NN	denotes	yeast
T7411	26319-26325	NN	denotes	domain
T7410	26293-26296	DT	denotes	the
T7409	26290-26292	IN	denotes	to
T7408	26284-26289	VBN	denotes	fused
T7407	26275-26283	NN	denotes	proteins
T7406	26266-26274	VBZ	denotes	produces
T7405	26260-26265	WDT	denotes	which
T7404	26258-26260	,	denotes	,
T7403	26246-26251	NN	denotes	pPC86
T7402	26252-26258	NN	denotes	vector
T7401	26242-26245	DT	denotes	the
T7400	26239-26241	IN	denotes	in
T7399	26223-26226	VBD	denotes	was
T7398	26227-26238	VBN	denotes	constructed
T7397	26215-26222	NN	denotes	library
T7396	26211-26214	DT	denotes	The
T7395	26210-26326	sentence	denotes	The library was constructed in the pPC86 vector, which produces proteins fused to the yeast GAL4 activation domain.
T7394	26209-26210	.	denotes	.
T7393	26192-26198	NN	denotes	pDBLeu
T7392	26184-26191	NN	denotes	PAX6CTP
T7391	26180-26183	CC	denotes	and
T7390	26172-26179	NN	denotes	PAX6PST
T7389	26199-26209	NNS	denotes	constructs
T7388	26168-26171	DT	denotes	the
T7387	26163-26167	IN	denotes	with
T7386	26150-26153	VBD	denotes	was
T7385	26148-26149	-RRB-	denotes	)
T7384	26138-26148	NNP	denotes	Invitrogen
T7383	26136-26138	,	denotes	,
T7382	26128-26136	NNP	denotes	ProQuest
T7381	26127-26128	-LRB-	denotes	(
T7380	26154-26162	VBN	denotes	screened
T7379	26114-26118	NN	denotes	cDNA
T7378	26108-26113	NN	denotes	brain
T7377	26102-26107	NN	denotes	mouse
T7376	26119-26126	NN	denotes	library
T7375	26100-26101	DT	denotes	A
T7374	26099-26210	sentence	denotes	A mouse brain cDNA library (ProQuest, Invitrogen) was screened with the PAX6PST and PAX6CTP pDBLeu constructs.
T7373	26084-26091	NN	denotes	library
T7372	26076-26077	HYPH	denotes	-
T7371	26077-26083	NN	denotes	hybrid
T7370	26073-26076	CD	denotes	two
T7369	26092-26099	NNS	denotes	screens
T7368	26067-26072	NN	denotes	Yeast
T6664	24179-24180	.	denotes	.
T6663	24178-24179	-RRB-	denotes	]
T6662	24175-24176	,	denotes	,
T6661	24173-24175	CD	denotes	25
T6660	24176-24178	CD	denotes	26
T6659	24172-24173	-LRB-	denotes	[
T6658	24155-24164	NN	denotes	consensus
T6657	24149-24154	NN	denotes	JPRED
T6656	24165-24171	NN	denotes	method
T6655	24145-24148	DT	denotes	the
T6654	24139-24144	VBG	denotes	using
T6653	24125-24128	VBD	denotes	was
T6652	24129-24138	VBN	denotes	performed
T6651	24114-24124	NN	denotes	prediction
T6650	24104-24113	NN	denotes	structure
T6649	24094-24103	JJ	denotes	Secondary
T6648	24093-24180	sentence	denotes	Secondary structure prediction was performed using the JPRED consensus method [25,26].
T6647	24092-24093	.	denotes	.
T6646	24091-24092	-RRB-	denotes	]
T6645	24089-24091	CD	denotes	24
T6644	24088-24089	-LRB-	denotes	[
T6643	24080-24087	NNP	denotes	CLUSTAL
T6642	24074-24079	VBG	denotes	using
T6641	24061-24065	VBD	denotes	were
T6640	24056-24060	NN	denotes	PAX6
T6639	24050-24055	JJ	denotes	human
T6638	24047-24049	IN	denotes	of
T6637	24037-24038	HYPH	denotes	-
T6636	24036-24037	NN	denotes	C
T6635	24038-24046	NN	denotes	terminus
T6634	24032-24035	DT	denotes	the
T6633	24029-24031	IN	denotes	to
T6632	24018-24028	JJ	denotes	homologous
T6631	24011-24017	RB	denotes	highly
T6630	24006-24010	VBD	denotes	were
T6629	24001-24005	WDT	denotes	that
T6628	24066-24073	VBN	denotes	aligned
T6627	23991-24000	NNS	denotes	sequences
T6626	23983-23990	NN	denotes	Protein
T6625	23982-24093	sentence	denotes	Protein sequences that were highly homologous to the C-terminus of human PAX6 were aligned using CLUSTAL [24].
T6624	23981-23982	.	denotes	.
T6623	23980-23981	-RRB-	denotes	]
T7658	27591-27597	NN	denotes	insert
T7657	27582-27585	DT	denotes	the
T7656	27573-27581	VB	denotes	identify
T7655	27570-27572	TO	denotes	to
T7654	27555-27559	VBD	denotes	were
T7653	27560-27569	VBN	denotes	performed
T7652	27546-27554	NNS	denotes	searches
T7651	27540-27545	NNP	denotes	BLAST
T7650	27539-27603	sentence	denotes	BLAST searches were performed to identify the cDNA insert [24].
T7649	27538-27539	.	denotes	.
T7648	27529-27538	VBN	denotes	sequenced
T7647	27517-27521	NN	denotes	cDNA
T7646	27522-27528	NN	denotes	insert
T7645	27513-27516	DT	denotes	the
T7644	27509-27512	CC	denotes	and
T7643	27493-27494	HYPH	denotes	/
T7642	27489-27493	NN	denotes	URA3
T7641	27488-27489	HYPH	denotes	/
T7640	27494-27498	NN	denotes	LacZ
T7639	27484-27488	NN	denotes	HIS3
T7638	27499-27508	NNS	denotes	positives
T7637	27480-27483	DT	denotes	all
T7636	27475-27479	IN	denotes	from
T7635	27462-27465	VBD	denotes	was
T7634	27466-27474	VBN	denotes	isolated
T7633	27449-27453	NN	denotes	prey
T7632	27443-27448	NN	denotes	pPC86
T7631	27454-27461	NN	denotes	plasmid
T7630	27439-27442	DT	denotes	The
T7629	27438-27539	sentence	denotes	The pPC86 prey plasmid was isolated from all HIS3/URA3/LacZ positives and the cDNA insert sequenced.
T7628	27437-27438	.	denotes	.
T7627	27426-27427	CD	denotes	3
T7626	27428-27437	NNS	denotes	reporters
T7625	27422-27425	DT	denotes	all
T7624	27418-27421	IN	denotes	for
T7623	27405-27409	RB	denotes	then
T7622	27400-27404	VBD	denotes	were
T7621	27410-27417	VBN	denotes	assayed
T7620	27390-27399	NNS	denotes	positives
T7619	27385-27389	NN	denotes	HIS3
T7618	27384-27438	sentence	denotes	HIS3 positives were then assayed for all 3 reporters.
T7617	27383-27384	.	denotes	.
T7616	27373-27383	NN	denotes	activation
T7615	27368-27372	NN	denotes	HIS3
T7614	27364-27367	IN	denotes	for
T7613	27358-27363	VB	denotes	check
T7612	27355-27357	TO	denotes	to
T7611	27345-27354	NN	denotes	histidine
T7610	27337-27344	VBG	denotes	lacking
T7609	27330-27336	NN	denotes	medium
T7608	27327-27329	IN	denotes	on
T7607	27315-27319	VBD	denotes	were
T7606	27313-27314	-RRB-	denotes	)
T7605	27308-27309	SYM	denotes	×
T7604	27306-27307	CD	denotes	5
T7603	27310-27313	CD	denotes	107
T7602	27305-27306	-LRB-	denotes	(
T7601	27320-27326	VBN	denotes	plated
T7600	27291-27304	NNS	denotes	Transformants
T7599	27290-27384	sentence	denotes	Transformants (5 × 107) were plated on medium lacking histidine to check for HIS3 activation.
T7598	27289-27290	.	denotes	.
T7597	27282-27289	NN	denotes	PAX6PST
T7596	27275-27281	NN	denotes	pDBLeu
T7595	27272-27274	CC	denotes	or
T7594	27264-27271	NN	denotes	PAX6CTP
T7593	27257-27263	NN	denotes	pDBLeu
T7592	27244-27248	NN	denotes	bait
T7591	27249-27256	NN	denotes	plasmid
T7590	27240-27243	DT	denotes	the
T7589	27236-27239	CC	denotes	and
T7588	27223-27227	NN	denotes	cDNA
T7587	27228-27235	NN	denotes	library
T7586	27219-27222	DT	denotes	the
T7585	27214-27218	IN	denotes	with
T7584	27194-27198	VBD	denotes	were
T7583	27182-27187	NN	denotes	yeast
T7582	27175-27181	NN	denotes	MaV203
T7581	27188-27193	NNS	denotes	cells
T7580	27165-27174	JJ	denotes	competent
T7579	27154-27164	RB	denotes	chemically
T7578	27152-27154	,	denotes	,
T7577	27199-27213	VBN	denotes	co-transformed
T7576	27145-27152	RB	denotes	Briefly
T7575	27144-27290	sentence	denotes	Briefly, chemically competent MaV203 yeast cells were co-transformed with the cDNA library and the bait plasmid pDBLeu PAX6CTP or pDBLeu PAX6PST.
T7574	27143-27144	.	denotes	.
T7573	27131-27133	POS	denotes	's
T7572	27134-27143	NNS	denotes	protocols
T7571	27123-27131	NN	denotes	supplier
T7570	27119-27122	DT	denotes	the
T7569	27116-27118	IN	denotes	to
T7568	27106-27115	VBG	denotes	according
T7567	27102-27105	RP	denotes	out
T7566	27089-27093	VBD	denotes	were
T7565	27094-27101	VBN	denotes	carried
T7564	27078-27088	NNS	denotes	procedures
T7563	27074-27077	DT	denotes	All
T7562	27073-27144	sentence	denotes	All procedures were carried out according to the supplier's protocols.
T7561	27072-27073	.	denotes	.
T7560	27071-27072	-RRB-	denotes	)
T7559	27070-27071	NN	denotes	E
T7558	27069-27070	-LRB-	denotes	(
T7557	27058-27068	NN	denotes	interactor
T7556	27051-27057	JJ	denotes	strong
T7555	27048-27050	IN	denotes	to
T7554	27046-27047	-RRB-	denotes	)
T7553	27045-27046	NN	denotes	A
T7552	27044-27045	-LRB-	denotes	(
T7551	27029-27043	NN	denotes	non-interactor
T7550	27024-27028	IN	denotes	from
T7549	27018-27023	VBP	denotes	range
T7548	27012-27017	WDT	denotes	which
T7547	27010-27012	,	denotes	,
T7546	27009-27010	NN	denotes	E
T7545	27008-27009	SYM	denotes	-
T7544	27007-27008	NN	denotes	A
T7543	26993-26998	NN	denotes	yeast
T7542	26985-26992	NN	denotes	control
T7541	26976-26984	NNP	denotes	ProQuest
T7540	26971-26975	CD	denotes	five
T7539	26999-27006	NNS	denotes	strains
T7538	26967-26970	DT	denotes	the
T7537	26962-26966	IN	denotes	with
T7536	26953-26961	NN	denotes	parallel
T7535	26950-26952	IN	denotes	in
T7534	26946-26949	RP	denotes	out
T7533	26933-26937	VBD	denotes	were
T7532	26938-26945	VBN	denotes	carried
T7531	26926-26932	NNS	denotes	assays
T7530	26922-26925	DT	denotes	All
T7529	26921-27073	sentence	denotes	All assays were carried out in parallel with the five ProQuest control yeast strains A-E, which range from non-interactor (A) to strong interactor (E).
T7528	26920-26921	.	denotes	.
T7527	26900-26901	HYPH	denotes	-
T7526	26901-26914	NN	denotes	galactosidase
T7525	26896-26900	NN	denotes	beta
T7524	26915-26920	NN	denotes	assay
T7523	26894-26895	DT	denotes	a
T7522	26891-26893	IN	denotes	in
T7521	26886-26890	JJ	denotes	blue
T7520	26878-26880	TO	denotes	to
T7519	26881-26885	VB	denotes	turn
T7518	26873-26874	HYPH	denotes	-
T7517	26874-26877	NN	denotes	gal
T7516	26872-26873	NN	denotes	X
T7515	26865-26871	VBZ	denotes	causes
T7514	26854-26864	NN	denotes	activation
T7513	26849-26853	NN	denotes	LacZ
T7512	26848-26921	sentence	denotes	LacZ activation causes X-gal to turn blue in a beta-galactosidase assay.
T7511	26847-26848	.	denotes	.
T7510	26841-26847	NN	denotes	uracil
T7509	26833-26840	VBG	denotes	lacking
T7508	26826-26832	NNS	denotes	plates
T7507	26823-26825	IN	denotes	on
T7506	26816-26822	NN	denotes	growth
T7505	26792-26796	NN	denotes	URA3
T7504	26797-26807	NN	denotes	activation
T7503	26785-26791	JJ	denotes	strong
T7502	26808-26815	VBZ	denotes	permits
T7501	26779-26784	IN	denotes	while
T7500	26774-26778	NN	denotes	acid
T7499	26766-26767	HYPH	denotes	-
T7498	26761-26766	JJ	denotes	fluro
T7497	26760-26761	HYPH	denotes	-
T7496	26767-26773	JJ	denotes	orotic
T7495	26759-26760	CD	denotes	5
T7494	26748-26758	VBG	denotes	containing
T7493	26741-26747	NNS	denotes	plates
T7492	26738-26740	IN	denotes	on
T7491	26731-26737	NN	denotes	growth
T7490	26720-26730	VBZ	denotes	suppresses
T7489	26704-26708	NN	denotes	URA3
T7488	26709-26719	NN	denotes	activation
T7487	26699-26703	JJ	denotes	Weak
T6622	23978-23980	CD	denotes	24
T6621	23977-23978	-LRB-	denotes	[
T6620	23968-23976	NNP	denotes	Research
T6619	23959-23967	NNP	denotes	Genomics
T6618	23955-23958	IN	denotes	for
T6617	23939-23947	NNP	denotes	Franklin
T6616	23930-23938	NNP	denotes	Rosalind
T6615	23948-23954	NNP	denotes	Centre
T6614	23926-23929	DT	denotes	the
T6613	23923-23925	IN	denotes	at
T6612	23895-23909	NNP	denotes	Bioinformatics
T6611	23910-23922	NNP	denotes	Applications
T6610	23891-23894	DT	denotes	the
T6609	23883-23890	IN	denotes	through
T6608	23873-23882	JJ	denotes	available
T6607	23859-23864	NNP	denotes	BLAST
T6606	23865-23872	NN	denotes	program
T6605	23855-23858	DT	denotes	the
T6604	23849-23854	VBG	denotes	using
T6603	23845-23848	RP	denotes	out
T6602	23832-23836	VBD	denotes	were
T6601	23837-23844	VBN	denotes	carried
T6600	23814-23822	NN	denotes	database
T6599	23823-23831	NNS	denotes	searches
T6598	23805-23813	NN	denotes	Sequence
T6597	23804-23982	sentence	denotes	Sequence database searches were carried out using the BLAST program available through the Bioinformatics Applications at the Rosalind Franklin Centre for Genomics Research [24].
T6596	23794-23804	NNS	denotes	techniques
T6595	23779-23793	NN	denotes	Bioinformatics
T6577	23767-23768	.	denotes	.
T6576	23746-23747	SYM	denotes	-
T6575	23747-23754	NN	denotes	protein
T6574	23739-23746	NN	denotes	protein
T6573	23755-23767	NNS	denotes	interactions
T6572	23730-23738	VBN	denotes	impaired
T6571	23727-23729	IN	denotes	by
T6570	23714-23716	VB	denotes	be
T6569	23710-23713	MD	denotes	may
T6568	23700-23709	NNS	denotes	mutations
T6567	23695-23699	NN	denotes	PAX6
T6566	23690-23694	IN	denotes	with
T6565	23681-23689	NNS	denotes	patients
T6564	23678-23680	IN	denotes	in
T6563	23661-23667	JJ	denotes	neural
T6562	23668-23677	NNS	denotes	anomalies
T6561	23657-23660	DT	denotes	the
T6560	23654-23656	IN	denotes	of
T6559	23649-23653	DT	denotes	some
T6558	23717-23726	VBN	denotes	explained
T6557	23644-23648	IN	denotes	that
T6556	23631-23635	RB	denotes	also
T6555	23636-23643	VBP	denotes	propose
T6554	23628-23630	PRP	denotes	We
T6553	23627-23768	sentence	denotes	We also propose that some of the neural anomalies in patients with PAX6 mutations may be explained by impaired protein-protein interactions.
T6552	23626-23627	.	denotes	.
T6551	23619-23626	NNS	denotes	neurons
T6550	23616-23618	IN	denotes	in
T6549	23605-23615	NN	denotes	expression
T6548	23600-23604	NN	denotes	gene
T6547	23597-23599	IN	denotes	in
T6546	23589-23596	NNS	denotes	changes
T6545	23579-23588	VBN	denotes	regulated
T6544	23576-23578	IN	denotes	to
T6543	23565-23570	MD	denotes	could
T6542	23554-23564	NN	denotes	signalling
T6541	23545-23553	JJ	denotes	synaptic
T6540	23539-23544	WDT	denotes	which
T6539	23571-23575	VB	denotes	lead
T6538	23536-23538	IN	denotes	by
T6537	23526-23535	NN	denotes	mechanism
T6536	23524-23525	DT	denotes	a
T6535	23515-23520	NN	denotes	DNCL1
T6534	23511-23514	CC	denotes	and
T6533	23504-23510	NN	denotes	HOMER3
T6532	23499-23503	IN	denotes	with
T6531	23494-23498	NN	denotes	PAX6
T6530	23491-23493	IN	denotes	of
T6529	23479-23490	NN	denotes	interaction
T6528	23475-23478	DT	denotes	the
T6527	23521-23523	VBZ	denotes	is
T6526	23470-23474	IN	denotes	that
T6525	23462-23469	VBP	denotes	suggest
T6524	23459-23461	PRP	denotes	We
T6523	23458-23627	sentence	denotes	We suggest that the interaction of PAX6 with HOMER3 and DNCL1 is a mechanism by which synaptic signalling could lead to regulated changes in gene expression in neurons.
T6522	23457-23458	.	denotes	.
T6521	23451-23457	NN	denotes	TRIM11
T6520	23447-23450	CC	denotes	and
T6519	23441-23446	NN	denotes	DNCL1
T6518	23439-23441	,	denotes	,
T6517	23433-23439	NN	denotes	HOMER3
T6516	23428-23432	IN	denotes	with
T6515	23413-23417	NN	denotes	PAX6
T6514	23387-23402	JJ	denotes	transcriptional
T6513	23368-23386	JJ	denotes	neurodevelopmental
T6512	23403-23412	NN	denotes	regulator
T6511	23364-23367	DT	denotes	the
T6510	23418-23427	VBZ	denotes	interacts
T6509	23359-23363	IN	denotes	that
T6508	23350-23358	NN	denotes	evidence
T6507	23338-23349	JJ	denotes	preliminary
T6506	23323-23327	VBP	denotes	have
T6505	23328-23337	VBN	denotes	presented
T6504	23320-23322	PRP	denotes	We
T6448	23306-23307	.	denotes	.
T6447	23305-23306	-RRB-	denotes	]
T6446	23302-23303	,	denotes	,
T6445	23300-23302	CD	denotes	53
T6444	23303-23305	CD	denotes	54
T6443	23299-23300	-LRB-	denotes	[
T6442	23289-23298	NNS	denotes	mutations
T6441	23284-23288	NN	denotes	PAX6
T6440	23279-23283	IN	denotes	with
T6439	23267-23278	NNS	denotes	individuals
T6438	23264-23266	IN	denotes	in
T6437	23255-23263	VBN	denotes	observed
T6436	23239-23246	JJ	denotes	retinal
T6435	23247-23254	NNS	denotes	defects
T6434	23235-23238	DT	denotes	the
T6433	23231-23234	IN	denotes	for
T6432	23218-23230	NNS	denotes	implications
T6431	23208-23212	RB	denotes	also
T6430	23204-23207	MD	denotes	may
T6429	23182-23183	SYM	denotes	-
T6428	23183-23190	NN	denotes	protein
T6427	23175-23182	NN	denotes	protein
T6426	23170-23174	NN	denotes	PAX6
T6425	23191-23203	NNS	denotes	interactions
T6383	22919-22922	MD	denotes	may
T6382	22913-22918	NN	denotes	X423L
T6381	22908-22912	IN	denotes	with
T6380	22897-22907	VBN	denotes	associated
T6379	22882-22896	NN	denotes	polymicrogyria
T6378	22878-22881	DT	denotes	the
T6377	22874-22877	CC	denotes	and
T7133	25585-25591	NN	denotes	mutant
T7132	25603-25615	NN	denotes	substitution
T7131	25581-25584	DT	denotes	the
T7130	25572-25580	VBZ	denotes	contains
T7129	25566-25571	WDT	denotes	which
T7128	25564-25566	,	denotes	,
T7127	25563-25564	SYM	denotes	'
T7126	25562-25563	CD	denotes	3
T7125	25561-25562	HYPH	denotes	-
T7124	25555-25558	NN	denotes	TTG
T7123	25551-25554	NN	denotes	GTA
T7122	25547-25550	NN	denotes	CCA
T7121	25543-25546	NN	denotes	TGG
T7120	25539-25542	NN	denotes	TCT
T7119	25535-25538	NN	denotes	TAA
T7118	25531-25534	NN	denotes	CCG
T7117	25527-25530	NN	denotes	TTA
T7116	25523-25526	NN	denotes	TTT
T7115	25519-25522	NN	denotes	CGC
T7114	25515-25518	NN	denotes	GGC
T7113	25511-25514	NN	denotes	TGC
T7112	25507-25510	NN	denotes	TTT
T7111	25506-25507	HYPH	denotes	-
T7110	25505-25506	SYM	denotes	'
T7109	25504-25505	CD	denotes	5
T7108	25559-25561	NN	denotes	AG
T7107	25498-25503	NN	denotes	ST006
T7106	25487-25490	NN	denotes	PCR
T7105	25479-25486	JJ	denotes	reverse
T7104	25491-25497	NN	denotes	primer
T7103	25475-25478	DT	denotes	the
T7102	25469-25474	VBG	denotes	using
T7101	25465-25468	CC	denotes	but
T7100	25463-25465	,	denotes	,
T7099	25446-25453	NN	denotes	PAX6PST
T7098	25454-25463	NN	denotes	construct
T7097	25442-25445	DT	denotes	the
T7096	25439-25441	IN	denotes	as
T7095	25430-25434	JJ	denotes	same
T7094	25435-25438	NN	denotes	way
T7093	25426-25429	DT	denotes	the
T7092	25423-25425	IN	denotes	in
T7091	25409-25412	VBD	denotes	was
T7090	25407-25408	-RRB-	denotes	)
T7089	25402-25407	NN	denotes	Q422R
T7088	25401-25402	-LRB-	denotes	(
T7087	25399-25400	NN	denotes	G
T7086	25398-25399	SYM	denotes	>
T7085	25393-25398	NN	denotes	1627A
T7084	25384-25392	NN	denotes	mutation
T7083	25380-25383	DT	denotes	the
T7082	25369-25379	VBG	denotes	containing
T7081	25413-25422	VBN	denotes	generated
T7080	25348-25351	NN	denotes	PST
T7079	25352-25358	NN	denotes	domain
T7078	25343-25347	NN	denotes	PAX6
T7077	25359-25368	NN	denotes	construct
T7076	25341-25342	DT	denotes	A
T7075	25340-25629	sentence	denotes	A PAX6 PST domain construct containing the mutation 1627A>G (Q422R) was generated in the same way as the PAX6PST construct, but using the reverse PCR primer ST006 5'-TTT TGC GGC CGC TTT TTA CCG TAA TCT TGG CCA GTA TTG AG-3', which contains the mutant nucleotide substitution (underlined).
T7074	25339-25340	.	denotes	.
T7073	25324-25328	VBN	denotes	been
T7072	25320-25323	VBD	denotes	had
T7071	25313-25319	NNS	denotes	errors
T7070	25310-25312	DT	denotes	no
T7069	25329-25339	VBN	denotes	introduced
T7068	25305-25309	IN	denotes	that
T7067	25299-25304	VB	denotes	check
T7066	25296-25298	TO	denotes	to
T7065	25281-25285	VBD	denotes	were
T7064	25273-25280	NNS	denotes	linkers
T7063	25268-25272	IN	denotes	with
T7062	25265-25267	CC	denotes	or
T7061	25261-25264	NN	denotes	PCR
T7060	25258-25260	IN	denotes	by
T7059	25248-25257	VBN	denotes	generated
T7058	25286-25295	VBN	denotes	sequenced
T7057	25238-25247	NNS	denotes	fragments
T7056	25234-25237	DT	denotes	All
T7055	25233-25340	sentence	denotes	All fragments generated by PCR or with linkers were sequenced to check that no errors had been introduced.
T7054	25232-25233	.	denotes	.
T7053	25215-25226	NN	denotes	restriction
T7052	25211-25214	CD	denotes	two
T7051	25227-25232	NNS	denotes	sites
T7050	25207-25210	DT	denotes	the
T7049	25199-25206	IN	denotes	between
T7048	25182-25191	JJ	denotes	synthetic
T7047	25192-25198	NN	denotes	linker
T7046	25180-25181	DT	denotes	a
T7045	25170-25179	VBG	denotes	inserting
T7044	25166-25169	CC	denotes	and
T7043	25164-25166	,	denotes	,
T7042	25147-25148	HYPH	denotes	-
T7041	25148-25156	JJ	denotes	terminal
T7040	25146-25147	NN	denotes	C
T7039	25157-25164	NN	denotes	peptide
T7038	25142-25145	DT	denotes	the
T7037	25138-25141	RP	denotes	out
T7036	25133-25137	VB	denotes	drop
T7035	25130-25132	TO	denotes	to
T7034	25125-25129	NN	denotes	NotI
T7033	25121-25124	CC	denotes	and
T7032	25116-25120	NN	denotes	NdeI
T7031	25111-25115	IN	denotes	with
T7030	25103-25110	NN	denotes	PAX6PST
T7029	25095-25102	VBG	denotes	cutting
T7028	25092-25094	IN	denotes	by
T7027	25083-25086	VBD	denotes	was
T7026	25087-25091	VBN	denotes	made
T7025	25078-25082	DT	denotes	This
T7024	25077-25233	sentence	denotes	This was made by cutting PAX6PST with NdeI and NotI to drop out the C-terminal peptide, and inserting a synthetic linker between the two restriction sites.
T7023	25076-25077	.	denotes	.
T7022	25075-25076	-RRB-	denotes	)
T7021	25072-25075	CD	denotes	390
T7020	25071-25072	SYM	denotes	–
T7019	25068-25071	CD	denotes	278
T7018	25067-25068	-LRB-	denotes	(
T7017	25049-25050	HYPH	denotes	-
T7016	25050-25058	JJ	denotes	terminal
T7015	25048-25049	NN	denotes	C
T7014	25059-25066	NN	denotes	peptide
T7013	25044-25047	DT	denotes	the
T7012	25038-25043	CC	denotes	minus
T7011	25027-25030	NN	denotes	PST
T7010	25031-25037	NN	denotes	domain
T7009	25023-25026	DT	denotes	the
T7008	25014-25022	VBZ	denotes	contains
T7007	25010-25011	HYPH	denotes	-
T7006	25011-25013	NN	denotes	CT
T7005	25003-25010	NN	denotes	PAX6PST
T7004	25002-25077	sentence	denotes	PAX6PST-CT contains the PST domain minus the C-terminal peptide (278–390).
T7003	25001-25002	.	denotes	.
T7002	25000-25001	-RRB-	denotes	)
T7001	24999-25000	NN	denotes	R
T7000	24998-24999	-LRB-	denotes	(
T6999	24992-24997	NN	denotes	ST005
T6998	24988-24991	CC	denotes	and
T6997	24986-24987	SYM	denotes	'
T6996	24985-24986	CD	denotes	3
T6995	24984-24985	HYPH	denotes	-
T6994	24978-24981	NN	denotes	TCA
T6993	24974-24977	NN	denotes	GAC
T6992	24970-24973	NN	denotes	CAG
T6991	24966-24969	NN	denotes	CAA
T6990	24962-24965	NN	denotes	CTT
T6989	24958-24961	NN	denotes	CCA
T6988	24954-24957	NN	denotes	CTA
T6987	24950-24953	NN	denotes	CGA
T6986	24946-24949	NN	denotes	AGT
T6985	24942-24945	NN	denotes	AAA
T6984	24941-24942	HYPH	denotes	-
T6983	24940-24941	SYM	denotes	'
T6982	24939-24940	CD	denotes	5
T6981	24937-24938	-RRB-	denotes	)
T6980	24936-24937	NN	denotes	F
T6979	24935-24936	-LRB-	denotes	(
T6978	24982-24984	NN	denotes	TT
T6977	24929-24934	NN	denotes	ST004
T6976	24924-24928	VBD	denotes	were
T6975	24916-24923	NNS	denotes	Primers
T6974	24915-25002	sentence	denotes	Primers were ST004 (F) 5'-AAA AGT CGA CTA CCA CTT CAA CAG GAC TCA TT-3' and ST005 (R).
T6973	24914-24915	.	denotes	.
T6972	24913-24914	-RRB-	denotes	)
T6971	24910-24913	CD	denotes	422
T6970	24909-24910	SYM	denotes	–
T6969	24906-24909	CD	denotes	391
T6968	24905-24906	-LRB-	denotes	(
T6967	24899-24904	JJ	denotes	alone
T6966	24881-24882	HYPH	denotes	-
T6965	24882-24890	JJ	denotes	terminal
T6964	24880-24881	NN	denotes	C
T6963	24872-24879	VBN	denotes	defined
T6962	24866-24871	RB	denotes	newly
T6961	24891-24898	NN	denotes	peptide
T6960	24862-24865	DT	denotes	the
T6959	24853-24861	VBZ	denotes	contains
T6958	24845-24852	NN	denotes	PAX6CTP
T6957	24844-24915	sentence	denotes	PAX6CTP contains the newly defined C-terminal peptide alone (391–422).
T6956	24843-24844	.	denotes	.
T6955	24842-24843	SYM	denotes	'
T6954	24841-24842	CD	denotes	3
T6953	24840-24841	HYPH	denotes	-
T6952	24833-24836	NN	denotes	GTA
T6951	24829-24832	NN	denotes	CCA
T6950	24825-24828	NN	denotes	TGG
T6949	24821-24824	NN	denotes	TCT
T6948	24817-24820	NN	denotes	TAA
T6947	24813-24816	NN	denotes	CTG
T6946	24809-24812	NN	denotes	TTA
T6945	24805-24808	NN	denotes	TTT
T6944	24801-24804	NN	denotes	GGC
T6943	24797-24800	NN	denotes	TGC
T6942	24793-24796	NN	denotes	TTT
T6941	24792-24793	HYPH	denotes	-
T6940	24791-24792	SYM	denotes	'
T6939	24790-24791	CD	denotes	5
T6938	24788-24789	-RRB-	denotes	)
T6937	24787-24788	NN	denotes	R
T6936	24786-24787	-LRB-	denotes	(
T6935	24837-24840	NN	denotes	TTG
T6934	24780-24785	NN	denotes	ST005
T6933	24776-24779	CC	denotes	and
T6932	24774-24775	SYM	denotes	'
T6931	24773-24774	CD	denotes	3
T6930	24772-24773	HYPH	denotes	-
T6928	24763-24766	NN	denotes	CCT
T6927	24759-24762	NN	denotes	ACA
T6926	24755-24758	NN	denotes	AAC
T6925	24751-24754	NN	denotes	AGC
T6924	24747-24750	NN	denotes	GCC
T6923	24743-24746	NN	denotes	ACT
T6922	24739-24742	NN	denotes	TCG
T6921	24735-24738	NN	denotes	AGT
T6920	24731-24734	NN	denotes	AAA
T6919	24730-24731	HYPH	denotes	-
T6918	24729-24730	SYM	denotes	'
T6909	24698-24844	sentence	denotes	Primers were ST001 (forward) 5'-AAA AGT TCG ACT GCC AGC AAC ACA CCT AGT C-3' and ST005 (R) 5'-TTT TGC GGC TTT TTA CTG TAA TCT TGG CCA GTA TTG-3'.
T6908	24697-24698	.	denotes	.
T6907	24696-24697	-RRB-	denotes	)
T6906	24684-24688	NN	denotes	PAX6
T6905	24676-24677	HYPH	denotes	-
T6904	24677-24683	NN	denotes	length
T6903	24672-24676	JJ	denotes	full
T6902	24689-24696	NN	denotes	protein
T6901	24668-24671	DT	denotes	the
T6900	24665-24667	IN	denotes	of
T6899	24661-24664	CD	denotes	422
T6898	24660-24661	SYM	denotes	–
T6897	24651-24656	NNS	denotes	acids
T6896	24645-24650	NN	denotes	amino
T6895	24657-24660	CD	denotes	278
T6894	24644-24645	-LRB-	denotes	(
T6893	24633-24636	NN	denotes	PST
T6892	24627-24632	JJ	denotes	whole
T6891	24637-24643	NN	denotes	domain
T6890	24623-24626	DT	denotes	the
T6889	24614-24622	VBZ	denotes	contains
T6888	24606-24613	NN	denotes	PAX6PST
T6887	24605-24698	sentence	denotes	PAX6PST contains the whole PST domain (amino acids 278–422 of the full-length PAX6 protein).
T6886	24604-24605	.	denotes	.
T6885	24590-24597	NN	denotes	binding
T6884	24586-24589	NN	denotes	DNA
T6883	24581-24585	NN	denotes	GAL4
T6882	24575-24580	NN	denotes	yeast
T6881	24598-24604	NN	denotes	domain
T6880	24571-24574	DT	denotes	the
T6879	24568-24570	IN	denotes	to
T6878	24562-24567	VBN	denotes	fused
T6877	24554-24561	NN	denotes	protein
T6876	24552-24553	DT	denotes	a
T6875	24542-24551	VBZ	denotes	generates
T6874	24536-24541	WDT	denotes	which
T6873	24534-24536	,	denotes	,
T6872	24533-24534	-RRB-	denotes	)
T6871	24523-24533	NNP	denotes	Invitrogen
T6870	24521-24523	,	denotes	,
T6869	24507-24508	HYPH	denotes	-
T6868	24508-24514	NN	denotes	Hybrid
T6867	24504-24507	CD	denotes	Two
T6866	24495-24503	NNP	denotes	ProQuest
T6865	24515-24521	NN	denotes	System
T6864	24494-24495	-LRB-	denotes	(
T6863	24476-24486	NN	denotes	expression
T6862	24469-24475	NN	denotes	pDBLeu
T6861	24487-24493	NN	denotes	vector
T6860	24465-24468	DT	denotes	the
T6859	24462-24464	IN	denotes	in
T6858	24446-24450	NN	denotes	cDNA
T6857	24441-24445	NN	denotes	PAX6
T6856	24451-24461	NNS	denotes	constructs
T6855	24435-24440	CD	denotes	three
T6854	24430-24434	VB	denotes	make
T6853	24427-24429	TO	denotes	to
T6852	24417-24421	VBD	denotes	were
T6851	24422-24426	VBN	denotes	used
T6850	24395-24405	NN	denotes	subcloning
T6849	24391-24394	CC	denotes	and
T6848	24387-24390	NN	denotes	PCR
T6847	24406-24416	NNS	denotes	techniques
T6846	24378-24386	JJ	denotes	Standard
T6845	24377-24605	sentence	denotes	Standard PCR and subcloning techniques were used to make three PAX6 cDNA constructs in the pDBLeu expression vector (ProQuest Two-Hybrid System, Invitrogen), which generates a protein fused to the yeast GAL4 DNA binding domain.
T6844	24376-24377	.	denotes	.
T6843	24375-24376	-RRB-	denotes	]
T6842	24373-24375	CD	denotes	27
T6841	24372-24373	-LRB-	denotes	[
T6840	24363-24366	NN	denotes	web
T6839	24346-24353	NN	denotes	Variant
T6838	24338-24345	JJ	denotes	Allelic
T6837	24354-24362	NN	denotes	Database
T6836	24333-24337	NN	denotes	PAX6
T6835	24327-24332	JJ	denotes	Human
T6834	24367-24371	NN	denotes	site
T6833	24323-24326	DT	denotes	the
T6832	24318-24322	IN	denotes	from
T6831	24308-24317	JJ	denotes	available
T6830	24288-24297	NN	denotes	reference
T6829	24280-24287	NN	denotes	protein
T6828	24276-24279	CC	denotes	and
T6827	24266-24270	NN	denotes	PAX6
T6826	24271-24275	NN	denotes	cDNA
T6825	24260-24265	JJ	denotes	human
T6824	24298-24307	NNS	denotes	sequences
T6823	24256-24259	DT	denotes	the
T6822	24253-24255	IN	denotes	on
T6821	24247-24252	VBN	denotes	based
T6820	24244-24246	VBZ	denotes	is
T6819	24229-24233	NN	denotes	acid
T6818	24223-24228	NN	denotes	amino
T6817	24219-24222	CC	denotes	and
T6816	24214-24218	NN	denotes	cDNA
T6815	24234-24243	NN	denotes	numbering
T6814	24210-24213	DT	denotes	All
T6813	24209-24377	sentence	denotes	All cDNA and amino acid numbering is based on the human PAX6 cDNA and protein reference sequences available from the Human PAX6 Allelic Variant Database web site [27].
T6812	24191-24192	HYPH	denotes	-
T6811	24192-24198	NN	denotes	hybrid
T6810	24188-24191	CD	denotes	two
T6809	24199-24209	NNS	denotes	constructs
T6808	24182-24187	NN	denotes	Yeast
T7154	25704-25705	-RRB-	denotes	)
T7247	26064-26065	.	denotes	.
T7246	26052-26055	VBD	denotes	was
T7245	26056-26064	VBN	denotes	inserted
T7244	26036-26042	NN	denotes	mutant
T7243	26043-26051	NN	denotes	sequence
T7242	26032-26035	DT	denotes	the
T7241	26028-26031	CC	denotes	and
T7240	26026-26028	,	denotes	,
T7239	26009-26010	HYPH	denotes	-
T7238	26010-26018	JJ	denotes	terminal
T7237	26008-26009	NN	denotes	C
T7236	26001-26007	JJ	denotes	normal
T7235	26019-26026	NN	denotes	peptide
T7234	25997-26000	DT	denotes	the
T7233	25989-25996	VB	denotes	release
T7232	25986-25988	TO	denotes	to
T7231	25981-25985	NN	denotes	NotI
T7230	25977-25980	CC	denotes	and
T7229	25972-25976	NN	denotes	NdeI
T7228	25967-25971	IN	denotes	with
T7227	25959-25962	VBD	denotes	was
T7226	25963-25966	VBN	denotes	cut
T7225	25941-25948	NN	denotes	PAX6PST
T7224	25949-25958	NN	denotes	construct
T7223	25937-25940	DT	denotes	The
T7222	25936-26065	sentence	denotes	The PAX6PST construct was cut with NdeI and NotI to release the normal C-terminal peptide, and the mutant sequence was inserted.
T7221	25935-25936	.	denotes	.
T7220	25934-25935	SYM	denotes	'
T7219	25933-25934	CD	denotes	3
T7218	25932-25933	HYPH	denotes	-
T7217	25926-25929	NN	denotes	TGT
T7216	25922-25925	NN	denotes	CAT
T7215	25918-25921	NN	denotes	CTA
T7214	25914-25917	NN	denotes	AGT
T7213	25910-25913	NN	denotes	TCC
T7212	25906-25909	NN	denotes	CCA
T7211	25902-25905	NN	denotes	CAT
T7210	25898-25901	NN	denotes	CCG
T7209	25894-25897	NN	denotes	CGG
T7208	25890-25893	NN	denotes	TTG
T7207	25889-25890	HYPH	denotes	-
T7206	25888-25889	SYM	denotes	'
T7205	25887-25888	CD	denotes	5
T7204	25885-25886	-RRB-	denotes	)
T7203	25884-25885	NN	denotes	R
T7202	25883-25884	-LRB-	denotes	(
T7201	25930-25932	NN	denotes	TC
T7200	25877-25882	NN	denotes	ST031
T7199	25873-25876	CC	denotes	and
T7198	25871-25872	SYM	denotes	'
T7197	25870-25871	CD	denotes	3
T7196	25869-25870	HYPH	denotes	-
T7195	25864-25867	NN	denotes	ACA
T7194	25860-25863	NN	denotes	GAC
T7193	25856-25859	NN	denotes	GCA
T7192	25852-25855	NN	denotes	TAT
T7191	25848-25851	NN	denotes	ACA
T7190	25844-25847	NN	denotes	CCC
T7189	25843-25844	HYPH	denotes	-
T7188	25842-25843	SYM	denotes	'
T7187	25841-25842	CD	denotes	5
T7186	25839-25840	-RRB-	denotes	)
T7185	25838-25839	NN	denotes	F
T7184	25837-25838	-LRB-	denotes	(
T7183	25868-25869	NN	denotes	C
T7182	25831-25836	NN	denotes	ST015
T7181	25826-25830	VBD	denotes	were
T7180	25818-25825	NNS	denotes	Primers
T7179	25817-25936	sentence	denotes	Primers were ST015 (F) 5'-CCC ACA TAT GCA GAC ACA C-3' and ST031 (R) 5'-TTG CGG CCG CAT CCA TCC AGT CTA CAT TGT TC-3'.
T7178	25816-25817	.	denotes	.
T7177	25815-25816	-RRB-	denotes	)
T7176	25802-25805	NNP	denotes	van
T7175	25800-25801	NNP	denotes	V
T7174	25806-25815	NNP	denotes	Heyningen
T7173	25795-25799	NNP	denotes	Prof
T7172	25791-25794	CC	denotes	and
T7171	25778-25779	NNP	denotes	K
T7170	25780-25790	NNP	denotes	Williamson
T7169	25775-25777	NNP	denotes	Dr
T7168	25770-25774	IN	denotes	from
T7167	25763-25764	DT	denotes	a
T7166	25765-25769	NN	denotes	gift
T7165	25762-25763	-LRB-	denotes	(
T7164	25758-25761	NN	denotes	RNA
T7163	25746-25757	VBN	denotes	transcribed
T7162	25738-25745	JJ	denotes	reverse
T7161	25733-25737	IN	denotes	from
T7160	25729-25732	NN	denotes	PCR
T7159	25726-25728	IN	denotes	by
T7158	25711-25715	VBD	denotes	were
T7157	25709-25710	-RRB-	denotes	]
T7156	25707-25709	CD	denotes	12
T7155	25706-25707	-LRB-	denotes	[
T7153	25699-25704	NN	denotes	X423L
T7152	25698-25699	-LRB-	denotes	(
T7151	25689-25697	NN	denotes	1629insT
T7150	25685-25688	CC	denotes	and
T7149	25683-25684	-RRB-	denotes	]
T7148	25681-25683	CD	denotes	28
T7147	25680-25681	-LRB-	denotes	[
T7146	25670-25679	NN	denotes	1615del10
T7145	25660-25669	NNS	denotes	mutations
T7144	25656-25659	DT	denotes	the
T7143	25645-25655	VBG	denotes	containing
T7142	25716-25725	VBN	denotes	generated
T7141	25635-25644	NNS	denotes	sequences
T7140	25630-25634	NN	denotes	cDNA
T7139	25629-25817	sentence	denotes	cDNA sequences containing the mutations 1615del10 [28] and 1629insT (X423L) [12] were generated by PCR from reverse transcribed RNA (a gift from Dr K Williamson and Prof V van Heyningen).
T7138	25628-25629	.	denotes	.
T7137	25627-25628	-RRB-	denotes	)
T7136	25617-25627	JJ	denotes	underlined
T7135	25616-25617	-LRB-	denotes	(
T7134	25592-25602	NN	denotes	nucleotide
T6376	22864-22873	NN	denotes	1615del10
T6375	22859-22863	IN	denotes	with
T6374	22848-22858	VBN	denotes	associated
T6373	22923-22929	VB	denotes	result
T6372	22821-22837	JJ	denotes	neurobehavioural
T6371	22838-22847	NN	denotes	phenotype
T6370	22817-22820	DT	denotes	The
T6369	22816-23001	sentence	denotes	The neurobehavioural phenotype associated with 1615del10 and the polymicrogyria associated with X423L may result from a specific effect of these unusual C-terminal extension mutations.
T6368	22815-22816	.	denotes	.
T6367	22809-22815	NN	denotes	TRIM11
T6366	22805-22808	CC	denotes	and
T6365	22799-22804	NN	denotes	DNCL1
T6364	22797-22799	,	denotes	,
T6363	22791-22797	NN	denotes	HOMER3
T6362	22787-22790	CC	denotes	and
T6361	22782-22786	NN	denotes	PAX6
T6360	22774-22781	IN	denotes	between
T6359	22762-22773	NN	denotes	interaction
T6358	22753-22761	VBN	denotes	impaired
T6357	22750-22752	IN	denotes	by
T6356	22733-22739	RB	denotes	partly
T6355	22730-22732	VB	denotes	be
T6354	22726-22729	MD	denotes	may
T6353	22717-22725	NNS	denotes	patients
T6352	22708-22716	NN	denotes	aniridia
T6351	22705-22707	IN	denotes	in
T6350	22691-22695	VBN	denotes	been
T6349	22686-22690	VBP	denotes	have
T6348	22696-22704	VBN	denotes	observed
T6347	22681-22685	WDT	denotes	that
T6346	22665-22670	NN	denotes	brain
T6345	22671-22680	NNS	denotes	anomalies
T6344	22661-22664	DT	denotes	the
T6343	22740-22749	VBN	denotes	explained
T6342	22656-22660	IN	denotes	that
T6341	22648-22655	VBP	denotes	propose
T6340	22645-22647	PRP	denotes	We
T6339	22644-22816	sentence	denotes	We propose that the brain anomalies that have been observed in aniridia patients may be partly explained by impaired interaction between PAX6 and HOMER3, DNCL1 and TRIM11.
T6338	22643-22644	.	denotes	.
T6337	22642-22643	-RRB-	denotes	]
T6336	22640-22642	CD	denotes	52
T6335	22639-22640	-LRB-	denotes	[
T6334	22633-22638	NN	denotes	decay
T6333	22623-22624	HYPH	denotes	-
T6332	22624-22632	VBN	denotes	mediated
T6331	22615-22623	NN	denotes	nonsense
T6330	22612-22614	IN	denotes	by
T6329	22600-22602	VBZ	denotes	is
T6328	22589-22595	NN	denotes	mutant
T6327	22596-22599	NN	denotes	RNA
T6326	22585-22588	DT	denotes	the
T6325	22603-22611	VBN	denotes	degraded
T6324	22582-22584	IN	denotes	if
T6323	22578-22581	RB	denotes	all
T6322	22575-22577	RB	denotes	at
T6321	22567-22574	NN	denotes	protein
T6320	22564-22566	DT	denotes	no
T6319	22561-22563	CC	denotes	or
T6318	22552-22560	NN	denotes	proteins
T6317	22542-22551	VBN	denotes	truncated
T6316	22535-22541	VB	denotes	encode
T6315	22532-22534	TO	denotes	to
T6314	22520-22522	VB	denotes	be
T6313	22514-22519	MD	denotes	would
T6312	22523-22531	VBN	denotes	expected
T6311	22506-22513	NNS	denotes	alleles
T6310	22500-22505	DT	denotes	These
T6309	22499-22644	sentence	denotes	These alleles would be expected to encode truncated proteins or no protein at all if the mutant RNA is degraded by nonsense-mediated decay [52].
T6308	22498-22499	.	denotes	.
T6307	22497-22498	-RRB-	denotes	]
T6306	22494-22495	,	denotes	,
T6305	22493-22494	CD	denotes	2
T6304	22495-22497	CD	denotes	52
T6303	22492-22493	-LRB-	denotes	[
T6302	22478-22485	NN	denotes	reading
T6301	22473-22477	JJ	denotes	open
T6300	22468-22472	NN	denotes	PAX6
T6299	22486-22491	NN	denotes	frame
T6298	22464-22467	DT	denotes	the
T6297	22459-22463	IN	denotes	into
T6296	22441-22452	NN	denotes	termination
T6295	22431-22440	JJ	denotes	premature
T6294	22453-22458	NN	denotes	codon
T6293	22429-22430	DT	denotes	a
T6292	22419-22428	VBP	denotes	introduce
T6291	22414-22418	WDT	denotes	that
T6290	22404-22413	NNS	denotes	mutations
T6289	22400-22403	IN	denotes	for
T6288	22387-22399	JJ	denotes	heterozygous
T6287	22383-22386	VBP	denotes	are
T6286	22365-22373	NN	denotes	aniridia
T6285	22374-22382	NNS	denotes	patients
T6284	22360-22364	JJS	denotes	Most
T6283	22359-22499	sentence	denotes	Most aniridia patients are heterozygous for mutations that introduce a premature termination codon into the PAX6 open reading frame [2,52].
T6282	22358-22359	.	denotes	.
T6281	22341-22342	HYPH	denotes	-
T6280	22342-22350	JJ	denotes	terminal
T6279	22340-22341	NN	denotes	C
T6278	22351-22358	NN	denotes	peptide
T6277	22336-22339	DT	denotes	the
T6276	22332-22335	CC	denotes	and
T6275	22320-22331	NN	denotes	homeodomain
T6274	22316-22319	DT	denotes	the
T6273	22308-22315	IN	denotes	between
T6272	22297-22300	NN	denotes	PST
T6271	22301-22307	NN	denotes	domain
T6270	22293-22296	DT	denotes	the
T6269	22288-22292	IN	denotes	with
T6268	22278-22287	VBZ	denotes	interacts
T6267	22274-22277	CC	denotes	but
T6266	22272-22274	,	denotes	,
T6265	22255-22256	HYPH	denotes	-
T6264	22256-22264	JJ	denotes	terminal
T6263	22254-22255	NN	denotes	C
T6262	22265-22272	NN	denotes	peptide
T6261	22250-22253	DT	denotes	the
T6260	22245-22249	IN	denotes	with
T6259	22232-22235	RB	denotes	not
T6258	22227-22231	VBZ	denotes	does
T6038	21087-21089	,	denotes	,
T6037	21083-21087	NN	denotes	PAX6
T6036	21080-21082	IN	denotes	of
T6035	21066-21079	NN	denotes	co-expression
T6034	21057-21065	VBD	denotes	detected
T6033	21054-21056	PRP	denotes	We
T6032	21053-21194	sentence	denotes	We detected co-expression of PAX6, HOMER3, DNCL1 and TRIM11 by RT-PCR in human adult brain RNA (IH, L Harrison and A Brown, data not shown).
T6031	21052-21053	.	denotes	.
T6030	21051-21052	-RRB-	denotes	]
T6029	21048-21049	,	denotes	,
T6028	21047-21048	CD	denotes	8
T6027	21046-21047	,	denotes	,
T6026	21045-21046	CD	denotes	7
T6025	21044-21045	,	denotes	,
T6024	21043-21044	CD	denotes	2
T6023	21049-21051	CD	denotes	10
T6022	21042-21043	-LRB-	denotes	[
T6021	21029-21035	NN	denotes	tissue
T6020	21036-21041	NN	denotes	level
T6019	21025-21028	DT	denotes	the
T6018	21022-21024	IN	denotes	at
T6017	21017-21021	NN	denotes	PAX6
T6016	21012-21016	IN	denotes	with
T6015	20985-20990	CD	denotes	three
T6014	20991-21002	NNS	denotes	interactors
T6013	20981-20984	DT	denotes	all
T6012	20978-20980	IN	denotes	of
T6011	20967-20977	NN	denotes	expression
T6010	20963-20966	DT	denotes	the
T6009	21003-21011	VBZ	denotes	overlaps
T6008	20958-20962	RB	denotes	Thus
T6007	20957-21053	sentence	denotes	Thus the expression of all three interactors overlaps with PAX6 at the tissue level [2,7,8,10].
T6006	20956-20957	.	denotes	.
T6005	20955-20956	-RRB-	denotes	]
T6004	20952-20953	,	denotes	,
T6003	20950-20952	CD	denotes	44
T6002	20953-20955	CD	denotes	38
T6001	20949-20950	-LRB-	denotes	[
T6000	20943-20948	NN	denotes	brain
T5999	20939-20942	DT	denotes	the
T5998	20931-20938	VBP	denotes	include
T5997	20926-20930	WDT	denotes	that
T5996	20907-20917	NN	denotes	expression
T5995	20918-20925	NNS	denotes	domains
T5994	20902-20906	JJ	denotes	wide
T5993	20892-20896	DT	denotes	both
T5992	20885-20891	NN	denotes	TRIM11
T5991	20881-20884	CC	denotes	and
T5990	20897-20901	VBP	denotes	have
T5989	20875-20880	NN	denotes	DNCL1
T5988	20874-20957	sentence	denotes	DNCL1 and TRIM11 both have wide expression domains that include the brain [44,38].
T5987	20873-20874	.	denotes	.
T5986	20872-20873	-RRB-	denotes	]
T5985	20870-20872	CD	denotes	39
T5984	20869-20870	-LRB-	denotes	[
T5983	20858-20868	NN	denotes	cerebellum
T5982	20854-20857	CC	denotes	and
T5981	20842-20853	NN	denotes	hippocampus
T5980	20840-20842	,	denotes	,
T5979	20831-20840	NN	denotes	forebrain
T5978	20827-20830	DT	denotes	the
T5977	20824-20826	IN	denotes	in
T5976	20815-20817	VBZ	denotes	is
T5975	20812-20814	PRP	denotes	it
T5974	20818-20823	VBN	denotes	found
T5973	20806-20811	WRB	denotes	where
T5972	20800-20805	NN	denotes	brain
T5971	20797-20799	IN	denotes	in
T5970	20784-20788	VBN	denotes	been
T5969	20777-20783	RB	denotes	mainly
T5968	20773-20776	VBZ	denotes	has
T5967	20789-20796	VBN	denotes	studied
T5966	20770-20772	PRP	denotes	it
T5965	20766-20769	CC	denotes	but
T5964	20761-20765	NN	denotes	lung
T5963	20757-20760	CC	denotes	and
T5962	20750-20756	NN	denotes	thymus
T5961	20747-20749	IN	denotes	in
T5960	20733-20737	VBN	denotes	been
T5959	20729-20732	VBZ	denotes	has
T5958	20718-20728	NN	denotes	expression
T5957	20711-20717	NN	denotes	HOMER3
T5956	20709-20711	,	denotes	,
T5955	20697-20703	NN	denotes	tissue
T5954	20704-20709	NN	denotes	level
T5953	20693-20696	DT	denotes	the
T5952	20738-20746	VBN	denotes	detected
T5951	20690-20692	IN	denotes	At
T5950	20689-20874	sentence	denotes	At the tissue level, HOMER3 expression has been detected in thymus and lung but it has mainly been studied in brain where it is found in the forebrain, hippocampus and cerebellum [39].
T5949	20688-20689	.	denotes	.
T5948	20683-20688	NN	denotes	DNCL1
T5947	20679-20682	CC	denotes	and
T5946	20672-20678	NN	denotes	TRIM11
T5945	20667-20671	IN	denotes	with
T5944	20652-20657	MD	denotes	could
T5943	20647-20651	NN	denotes	PAX6
T5942	20639-20646	JJ	denotes	nuclear
T6917	24728-24729	CD	denotes	5
T6916	24726-24727	-RRB-	denotes	)
T6915	24719-24726	JJ	denotes	forward
T6914	24718-24719	-LRB-	denotes	(
T6913	24771-24772	NN	denotes	C
T6912	24712-24717	NN	denotes	ST001
T6911	24707-24711	VBD	denotes	were
T6910	24699-24706	NNS	denotes	Primers
T5941	20658-20666	VB	denotes	interact
T5940	20633-20638	IN	denotes	while
T5939	20631-20633	,	denotes	,
T5938	20617-20622	CD	denotes	three
T5937	20623-20631	NN	denotes	proteins
T5936	20613-20616	DT	denotes	all
T5935	20608-20612	IN	denotes	with
T5934	20587-20598	RB	denotes	potentially
T5933	20581-20586	MD	denotes	could
T5932	20576-20580	NN	denotes	PAX6
T5931	20564-20575	JJ	denotes	cytoplasmic
T5930	20599-20607	VB	denotes	interact
T5929	20554-20563	RB	denotes	Therefore
T5928	20553-20689	sentence	denotes	Therefore cytoplasmic PAX6 could potentially interact with all three proteins, while nuclear PAX6 could interact with TRIM11 and DNCL1.
T5927	20552-20553	.	denotes	.
T5926	20551-20552	-RRB-	denotes	]
T5925	20549-20551	CD	denotes	38
T5924	20548-20549	-LRB-	denotes	[
T5923	20536-20547	JJ	denotes	cytoplasmic
T5922	20532-20535	CC	denotes	and
T5921	20524-20531	JJ	denotes	nuclear
T5920	20519-20523	CC	denotes	both
T5919	20516-20518	VBZ	denotes	is
T5918	20509-20515	NN	denotes	TRIM11
T5917	20505-20508	CC	denotes	and
T5916	20503-20505	,	denotes	,
T5915	20502-20503	-RRB-	denotes	]
T5914	20500-20502	CD	denotes	51
T5913	20499-20500	-LRB-	denotes	[
T5912	20485-20489	VBN	denotes	been
T5911	20481-20484	VBZ	denotes	has
T5910	20468-20480	NN	denotes	localisation
T5909	20460-20467	JJ	denotes	nuclear
T5908	20490-20498	VBN	denotes	reported
T5907	20451-20459	IN	denotes	although
T5906	20449-20451	,	denotes	,
T5905	20438-20449	JJ	denotes	cytoplasmic
T5904	20430-20437	RB	denotes	chiefly
T5903	20427-20429	VBZ	denotes	is
T5902	20421-20426	NN	denotes	DNCL1
T5901	20419-20421	,	denotes	,
T5900	20418-20419	-RRB-	denotes	]
T5899	20416-20418	CD	denotes	39
T5898	20415-20416	-LRB-	denotes	[
T5897	20405-20414	NN	denotes	cytoplasm
T5896	20401-20404	DT	denotes	the
T5895	20397-20400	CC	denotes	and
T5894	20393-20396	NN	denotes	PSD
T5893	20389-20392	DT	denotes	the
T5892	20381-20388	IN	denotes	between
T5891	20371-20380	NN	denotes	interface
T5890	20367-20370	DT	denotes	the
T5889	20364-20366	IN	denotes	at
T5888	20344-20357	RB	denotes	predominantly
T5887	20341-20343	VBZ	denotes	is
T5886	20334-20340	NN	denotes	HOMER3
T5885	20332-20334	,	denotes	,
T5884	20312-20323	VBG	denotes	interacting
T5883	20303-20311	JJ	denotes	putative
T5882	20324-20332	NN	denotes	proteins
T5881	20299-20302	DT	denotes	the
T5880	20296-20298	IN	denotes	of
T5879	20271-20282	JJ	denotes	subcellular
T5878	20283-20295	NN	denotes	localisation
T5877	20267-20270	DT	denotes	the
T5876	20358-20363	VBN	denotes	found
T5875	20257-20266	VBG	denotes	Regarding
T5874	20256-20553	sentence	denotes	Regarding the subcellular localisation of the putative interacting proteins, HOMER3 is predominantly found at the interface between the PSD and the cytoplasm [39], DNCL1 is chiefly cytoplasmic, although nuclear localisation has been reported [51], and TRIM11 is both nuclear and cytoplasmic [38].
T5873	20255-20256	.	denotes	.
T5872	20240-20242	VB	denotes	be
T5871	20243-20255	VBN	denotes	investigated
T5870	20237-20239	TO	denotes	to
T5869	20227-20229	,	denotes	,
T5868	20224-20227	NN	denotes	PSD
T5867	20220-20223	DT	denotes	the
T5866	20215-20219	IN	denotes	with
T5865	20203-20214	NN	denotes	association
T5864	20200-20202	DT	denotes	an
T5863	20197-20199	IN	denotes	of
T5862	20185-20196	NN	denotes	possibility
T5861	20181-20184	DT	denotes	the
T5860	20177-20180	CC	denotes	and
T5859	20175-20177	,	denotes	,
T5858	20167-20175	NNS	denotes	neurones
T5857	20164-20166	IN	denotes	in
T5856	20139-20150	JJ	denotes	subcellular
T5855	20151-20163	NN	denotes	localisation
T5854	20135-20138	PRP$	denotes	its
T5853	20127-20134	RB	denotes	however
T5852	20125-20126	:	denotes	;
T5851	20124-20125	-RRB-	denotes	]
T5850	20122-20124	CD	denotes	49
T5849	20121-20122	-LRB-	denotes	[
T5848	20115-20120	NN	denotes	brain
T5847	20112-20114	IN	denotes	in
T5846	20103-20111	JJ	denotes	abundant
T5845	20092-20102	RB	denotes	relatively
T5844	20089-20091	VBZ	denotes	is
T5843	20075-20076	HYPH	denotes	-
T5842	20076-20080	JJ	denotes	less
T5841	20069-20075	VBN	denotes	paired
T5840	20081-20088	NN	denotes	isoform
T5839	20065-20068	DT	denotes	the
T5838	20060-20064	NNS	denotes	mice
T5837	20229-20236	VBZ	denotes	remains
T5836	20057-20059	IN	denotes	In
T5835	20056-20256	sentence	denotes	In mice the paired-less isoform is relatively abundant in brain [49]; however its subcellular localisation in neurones, and the possibility of an association with the PSD, remains to be investigated.
T5834	20055-20056	.	denotes	.
T5833	20054-20055	-RRB-	denotes	]
T5832	20052-20054	CD	denotes	51
T5831	20051-20052	SYM	denotes	-
T5830	20049-20051	CD	denotes	49
T5829	20048-20049	-LRB-	denotes	[
T5828	20042-20047	RB	denotes	alone
T5827	20030-20041	NN	denotes	homeodomain
T5826	20026-20029	DT	denotes	the
T5825	20018-20025	IN	denotes	through
T5824	20014-20017	NN	denotes	DNA
T5823	20008-20013	VBZ	denotes	binds
T5822	20004-20007	CC	denotes	and
T5821	20002-20004	,	denotes	,
T5820	19991-20002	JJ	denotes	cytoplasmic
T5819	19987-19990	CC	denotes	and
T5818	19979-19986	JJ	denotes	nuclear
T5817	19974-19978	CC	denotes	both
T5816	19971-19973	VBZ	denotes	is
T5815	19969-19971	,	denotes	,
T5814	19956-19962	JJ	denotes	paired
T5813	19963-19969	NN	denotes	domain
T5812	19952-19955	DT	denotes	the
T5811	19946-19951	VBZ	denotes	lacks
T5810	19941-19945	WDT	denotes	that
T5809	19933-19940	NN	denotes	isoform
T5808	19930-19932	DT	denotes	an
T5807	19926-19929	IN	denotes	for
T5806	19917-19925	NN	denotes	nematode
T5805	19913-19916	CC	denotes	and
T5804	19907-19912	NN	denotes	quail
T5803	19905-19907	,	denotes	,
T5802	19900-19905	NN	denotes	mouse
T5801	19897-19899	IN	denotes	in
T5800	19888-19896	NN	denotes	evidence
T5799	19883-19887	JJ	denotes	good
T5798	19874-19879	EX	denotes	there
T5797	19872-19874	,	denotes	,
T5796	19865-19872	JJ	denotes	nuclear
T5795	19851-19864	RB	denotes	predominantly
T5794	19880-19882	VBZ	denotes	is
T5793	19835-19839	NN	denotes	PAX6
T5792	19827-19828	HYPH	denotes	-
T5791	19828-19834	NN	denotes	length
T5790	19823-19827	JJ	denotes	full
T5789	19840-19847	NN	denotes	protein
T5788	19819-19822	DT	denotes	the
T5787	19848-19850	VBZ	denotes	is
T5786	19810-19818	IN	denotes	Although
T5785	19809-20056	sentence	denotes	Although the full-length PAX6 protein is predominantly nuclear, there is good evidence in mouse, quail and nematode for an isoform that lacks the paired domain, is both nuclear and cytoplasmic, and binds DNA through the homeodomain alone [49-51].
T5784	19808-19809	.	denotes	.
T5783	19807-19808	-RRB-	denotes	]
T5782	19804-19805	,	denotes	,
T5781	19802-19804	CD	denotes	47
T5780	19805-19807	CD	denotes	48
T5779	19801-19802	-LRB-	denotes	[
T5778	19793-19800	NN	denotes	nucleus
T5777	19789-19792	DT	denotes	the
T5776	19785-19788	CC	denotes	and
T5775	19777-19784	NN	denotes	synapse
T5774	19773-19776	DT	denotes	the
T5773	19765-19772	IN	denotes	between
T5772	19754-19764	NNS	denotes	messengers
T5771	19751-19753	IN	denotes	as
T5770	19747-19750	VBP	denotes	act
T5769	19741-19746	WDT	denotes	which
T5768	19739-19741	,	denotes	,
T5767	19735-19739	NN	denotes	CREB
T5766	19731-19734	CC	denotes	and
T5765	19725-19730	NN	denotes	STAT3
T5764	19695-19708	JJ	denotes	post-synaptic
T5763	19709-19716	NN	denotes	density
T5762	19691-19694	DT	denotes	the
T5761	19686-19690	IN	denotes	with
T5760	19678-19685	NNS	denotes	factors
T5759	19664-19677	NN	denotes	transcription
T5758	19661-19663	IN	denotes	of
T5757	19649-19660	NN	denotes	association
T5756	19645-19648	IN	denotes	for
T5755	19717-19724	VBP	denotes	include
T5754	19634-19644	NNS	denotes	Precedents
T5753	19633-19809	sentence	denotes	Precedents for association of transcription factors with the post-synaptic density include STAT3 and CREB, which act as messengers between the synapse and the nucleus [47,48].
T5752	19632-19633	.	denotes	.
T5751	19624-19632	NN	denotes	turnover
T5750	19616-19623	NN	denotes	protein
T5749	19611-19615	NN	denotes	PAX6
T5748	19608-19610	IN	denotes	in
T5747	19603-19607	NN	denotes	role
T5746	19601-19602	DT	denotes	a
T5745	19592-19595	MD	denotes	may
T5744	19589-19591	PRP	denotes	it
T5743	19587-19589	,	denotes	,
T5742	19586-19587	-RRB-	denotes	]
T5741	19584-19586	CD	denotes	46
T5740	19583-19584	-LRB-	denotes	[
T5739	19571-19582	NN	denotes	degradation
T5738	19563-19570	NN	denotes	protein
T5737	19560-19562	IN	denotes	in
T5736	19596-19600	VB	denotes	play
T5735	19546-19548	VBZ	denotes	is
T5734	19539-19545	NN	denotes	TRIM11
T5733	19549-19559	VBN	denotes	implicated
T5732	19533-19538	IN	denotes	Since
T5731	19532-19633	sentence	denotes	Since TRIM11 is implicated in protein degradation [46], it may play a role in PAX6 protein turnover.
T5730	19531-19532	.	denotes	.
T5729	19530-19531	-RRB-	denotes	]
T5728	19528-19530	CD	denotes	36
T5727	19527-19528	-LRB-	denotes	[
T5726	19519-19526	NN	denotes	nucleus
T6228	22097-22102	VB	denotes	alter
T6227	22080-22084	IN	denotes	that
T6226	22069-22079	VBG	denotes	suggesting
T6225	22067-22069	,	denotes	,
T6224	22061-22067	NN	denotes	TRIM11
T6223	22056-22060	IN	denotes	with
T6222	22044-22055	NN	denotes	interaction
T6221	22040-22043	DT	denotes	the
T6220	22021-22030	NNS	denotes	mutations
T6219	22017-22020	DT	denotes	the
T6218	22014-22016	IN	denotes	of
T6217	22031-22039	VBD	denotes	affected
T6216	22009-22013	NN	denotes	None
T6215	22008-22166	sentence	denotes	None of the mutations affected the interaction with TRIM11, suggesting that they do not alter the conformation of the more N-terminal part of the PST domain.
T6214	22007-22008	.	denotes	.
T6213	22006-22007	-RRB-	denotes	]
T6212	22004-22006	CD	denotes	28
T6211	22003-22004	-LRB-	denotes	[
T6210	21985-21986	HYPH	denotes	-
T6209	21986-21994	JJ	denotes	terminal
T6208	21984-21985	NN	denotes	C
T6207	21995-22002	NN	denotes	peptide
T6206	21980-21983	DT	denotes	the
T6205	21977-21979	IN	denotes	of
T6204	21965-21970	NN	denotes	amino
T6203	21963-21964	CD	denotes	5
T6202	21958-21962	JJ	denotes	last
T6201	21971-21976	NNS	denotes	acids
T6200	21954-21957	DT	denotes	the
T6199	21941-21945	RB	denotes	also
T6198	21946-21953	VBZ	denotes	removes
T6197	21922-21931	NN	denotes	1615del10
T6196	21932-21940	NN	denotes	mutation
T6195	21918-21921	DT	denotes	The
T6194	21917-22008	sentence	denotes	The 1615del10 mutation also removes the last 5 amino acids of the C-terminal peptide [28].
T6193	21916-21917	.	denotes	.
T6192	21909-21916	NN	denotes	protein
T6191	21905-21908	DT	denotes	the
T6190	21902-21904	IN	denotes	of
T6189	21888-21889	HYPH	denotes	-
T6188	21889-21897	JJ	denotes	terminal
T6187	21887-21888	NN	denotes	C
T6186	21898-21901	NN	denotes	end
T6185	21883-21886	DT	denotes	the
T6184	21880-21882	IN	denotes	of
T6183	21867-21879	NN	denotes	conformation
T6182	21863-21866	DT	denotes	the
T6181	21855-21862	VB	denotes	disrupt
T6180	21852-21854	TO	denotes	to
T6179	21840-21842	VB	denotes	be
T6178	21834-21839	MD	denotes	might
T6177	21843-21851	VBN	denotes	expected
T6176	21829-21833	WDT	denotes	that
T6175	21818-21828	NNS	denotes	extensions
T6174	21809-21817	JJ	denotes	abnormal
T6173	21804-21808	IN	denotes	with
T6172	21795-21803	NN	denotes	proteins
T6171	21784-21794	VBG	denotes	generating
T6170	21779-21783	RB	denotes	thus
T6169	21777-21779	,	denotes	,
T6168	21758-21770	JJ	denotes	untranslated
T6167	21756-21757	SYM	denotes	'
T6166	21755-21756	CD	denotes	3
T6165	21771-21777	NN	denotes	region
T6164	21751-21754	DT	denotes	the
T6163	21746-21750	IN	denotes	into
T6162	21734-21745	NN	denotes	translation
T6161	21728-21733	VB	denotes	cause
T6160	21725-21727	TO	denotes	to
T6159	21702-21711	NN	denotes	1615del10
T6158	21698-21701	CC	denotes	and
T6157	21692-21697	NN	denotes	X423L
T6156	21712-21721	NNS	denotes	mutations
T6155	21688-21691	DT	denotes	the
T6154	21685-21687	IN	denotes	of
T6153	21722-21724	VBZ	denotes	is
T6152	21668-21677	VBN	denotes	predicted
T6151	21678-21684	NN	denotes	effect
T6150	21664-21667	DT	denotes	The
T6149	21663-21917	sentence	denotes	The predicted effect of the X423L and 1615del10 mutations is to cause translation into the 3' untranslated region, thus generating proteins with abnormal extensions that might be expected to disrupt the conformation of the C-terminal end of the protein.
T6148	21662-21663	.	denotes	.
T6147	21657-21662	NN	denotes	DNCL1
T6146	21653-21656	CC	denotes	and
T6145	21646-21652	NN	denotes	HOMER3
T6144	21641-21645	IN	denotes	with
T6143	21629-21640	NN	denotes	interaction
T6142	21625-21628	DT	denotes	the
T6141	21615-21624	VBD	denotes	abolished
T6140	21604-21614	RB	denotes	completely
T6139	21601-21603	CC	denotes	or
T6138	21584-21592	RB	denotes	severely
T6137	21593-21600	VBN	denotes	reduced
T6136	21564-21573	NN	denotes	1615del10
T6135	21560-21563	CC	denotes	and
T6134	21554-21559	NN	denotes	X423L
T6133	21574-21583	NNS	denotes	mutations
T6132	21550-21553	DT	denotes	The
T6131	21549-21663	sentence	denotes	The X423L and 1615del10 mutations severely reduced or completely abolished the interaction with HOMER3 and DNCL1.
T6130	21548-21549	.	denotes	.
T6129	21543-21548	NN	denotes	DNCL1
T6128	21539-21542	CC	denotes	and
T6127	21532-21538	NN	denotes	HOMER3
T6126	21527-21531	IN	denotes	with
T6125	21515-21526	NN	denotes	interaction
T6124	21511-21514	DT	denotes	the
T6123	21508-21510	IN	denotes	in
T6122	21498-21507	NN	denotes	reduction
T6121	21496-21497	DT	denotes	a
T6120	21487-21489	,	denotes	,
T6119	21483-21487	NN	denotes	PAX6
T6118	21480-21482	IN	denotes	of
T6117	21466-21470	NN	denotes	acid
T6116	21460-21465	NN	denotes	amino
T6115	21455-21459	JJ	denotes	last
T6114	21471-21479	NN	denotes	position
T6113	21451-21454	DT	denotes	the
T6112	21448-21450	IN	denotes	at
T6111	21426-21434	NN	denotes	arginine
T6110	21423-21425	IN	denotes	to
T6109	21413-21422	NN	denotes	glutamine
T6108	21435-21447	NN	denotes	substitution
T6107	21411-21412	DT	denotes	a
T6106	21402-21410	VBZ	denotes	involves
T6105	21396-21401	WDT	denotes	which
T6104	21394-21396	,	denotes	,
T6103	21489-21495	VBD	denotes	caused
T6102	21380-21385	NN	denotes	Q422R
T6101	21386-21394	NN	denotes	mutation
T6100	21376-21379	DT	denotes	The
T6099	21375-21549	sentence	denotes	The Q422R mutation, which involves a glutamine to arginine substitution at the last amino acid position of PAX6, caused a reduction in the interaction with HOMER3 and DNCL1.
T6098	21374-21375	.	denotes	.
T6097	21357-21358	HYPH	denotes	-
T6096	21358-21366	JJ	denotes	terminal
T6095	21356-21357	NN	denotes	C
T6094	21351-21355	NN	denotes	PAX6
T6093	21367-21374	NN	denotes	peptide
T6092	21347-21350	DT	denotes	the
T6091	21344-21346	IN	denotes	in
T6090	21332-21335	VBP	denotes	are
T6089	21336-21343	VBN	denotes	located
T6088	21327-21331	WDT	denotes	that
T6087	21307-21316	VBG	denotes	occurring
T6086	21297-21306	RB	denotes	naturally
T6085	21317-21326	NNS	denotes	mutations
T6084	21291-21296	CD	denotes	three
T6083	21288-21290	IN	denotes	by
T6082	21275-21278	VBD	denotes	was
T6081	21269-21274	NN	denotes	DNCL1
T6080	21266-21268	CC	denotes	or
T6079	21259-21265	NN	denotes	HOMER3
T6078	21255-21258	CC	denotes	and
T6077	21244-21247	NN	denotes	PST
T6076	21248-21254	NN	denotes	domain
T6075	21240-21243	DT	denotes	the
T6074	21232-21239	IN	denotes	between
T6073	21220-21231	NN	denotes	interaction
T6072	21216-21219	DT	denotes	the
T6071	21279-21287	VBN	denotes	impaired
T6070	21211-21215	IN	denotes	that
T6069	21198-21210	VBD	denotes	demonstrated
T6068	21195-21197	PRP	denotes	We
T6067	21194-21375	sentence	denotes	We demonstrated that the interaction between the PST domain and HOMER3 or DNCL1 was impaired by three naturally occurring mutations that are located in the PAX6 C-terminal peptide.
T6066	21193-21194	.	denotes	.
T6065	21192-21193	-RRB-	denotes	)
T6064	21183-21186	RB	denotes	not
T6063	21187-21192	VBN	denotes	shown
T6062	21178-21182	NNS	denotes	data
T6061	21176-21178	,	denotes	,
T6060	21171-21176	NNP	denotes	Brown
T6059	21169-21170	NNP	denotes	A
T6058	21165-21168	CC	denotes	and
T6057	21156-21164	NNP	denotes	Harrison
T6056	21154-21155	NNP	denotes	L
T6055	21152-21154	,	denotes	,
T6054	21150-21152	NNP	denotes	IH
T6053	21149-21150	-LRB-	denotes	(
T6052	21139-21144	NN	denotes	brain
T6051	21133-21138	JJ	denotes	adult
T6050	21145-21148	NN	denotes	RNA
T6049	21127-21132	JJ	denotes	human
T6048	21124-21126	IN	denotes	in
T6047	21119-21120	HYPH	denotes	-
T6046	21120-21123	NN	denotes	PCR
T6045	21117-21119	NN	denotes	RT
T6044	21114-21116	IN	denotes	by
T6043	21107-21113	NN	denotes	TRIM11
T6042	21103-21106	CC	denotes	and
T6041	21097-21102	NN	denotes	DNCL1
T6040	21095-21097	,	denotes	,
T6039	21089-21095	NN	denotes	HOMER3
T5725	19515-19518	DT	denotes	the
T5724	19506-19514	VBG	denotes	reaching
T5723	19495-19505	RB	denotes	eventually
T5722	19493-19495	,	denotes	,
T5721	19474-19485	NN	denotes	microtubule
T5720	19486-19493	NN	denotes	network
T5719	19470-19473	DT	denotes	the
T5718	19464-19469	IN	denotes	along
T5717	19454-19463	NN	denotes	transport
T5716	19444-19445	HYPH	denotes	-
T5715	19445-19453	VBN	denotes	mediated
T5714	19438-19444	NN	denotes	dynein
T5713	19435-19437	IN	denotes	by
T5712	19426-19434	VBN	denotes	followed
T5711	19407-19412	NN	denotes	actin
T5710	19395-19396	HYPH	denotes	-
T5709	19396-19406	VBN	denotes	associated
T5708	19392-19395	NN	denotes	PSD
T5707	19413-19425	NN	denotes	cytoskeleton
T5706	19388-19391	DT	denotes	the
T5705	19382-19387	IN	denotes	along
T5704	19372-19381	NN	denotes	transport
T5703	19362-19363	HYPH	denotes	-
T5702	19363-19371	VBN	denotes	mediated
T5701	19360-19362	NN	denotes	Va
T5700	19353-19359	NN	denotes	myosin
T5699	19350-19352	IN	denotes	in
T5698	19333-19337	RB	denotes	then
T5697	19327-19332	MD	denotes	could
T5696	19338-19349	VB	denotes	participate
T5695	19312-19313	HYPH	denotes	/
T5694	19313-19318	NN	denotes	DNCL1
T5693	19308-19312	NN	denotes	PAX6
T5692	19319-19326	NN	denotes	complex
T5691	19304-19307	DT	denotes	The
T5690	19303-19532	sentence	denotes	The PAX6/DNCL1 complex could then participate in myosin Va-mediated transport along the PSD-associated actin cytoskeleton followed by dynein-mediated transport along the microtubule network, eventually reaching the nucleus [36].
T5689	19302-19303	.	denotes	.
T5688	19297-19302	NN	denotes	DNCL1
T5687	19292-19296	IN	denotes	with
T5686	19280-19282	TO	denotes	to
T5685	19283-19291	VB	denotes	interact
T5684	19277-19279	PRP	denotes	it
T5683	19268-19276	VBG	denotes	allowing
T5682	19266-19268	,	denotes	,
T5681	19258-19266	NN	denotes	activity
T5680	19249-19257	JJ	denotes	synaptic
T5679	19246-19248	IN	denotes	of
T5678	19239-19245	NN	denotes	result
T5677	19237-19238	DT	denotes	a
T5676	19234-19236	IN	denotes	as
T5675	19222-19224	VB	denotes	be
T5674	19218-19221	MD	denotes	may
T5673	19213-19217	NN	denotes	PAX6
T5672	19211-19213	,	denotes	,
T5671	19210-19211	-RRB-	denotes	]
T5670	19208-19210	CD	denotes	35
T5669	19207-19208	-LRB-	denotes	[
T5668	19198-19206	NN	denotes	proteins
T5667	19192-19197	NN	denotes	HOMER
T5666	19189-19191	IN	denotes	of
T5665	19176-19188	NN	denotes	dissociation
T5664	19225-19233	VBN	denotes	released
T5663	19158-19168	NN	denotes	activation
T5662	19149-19157	NN	denotes	receptor
T5661	19169-19175	VBZ	denotes	causes
T5660	19143-19148	IN	denotes	Since
T5659	19142-19303	sentence	denotes	Since receptor activation causes dissociation of HOMER proteins [35], PAX6 may be released as a result of synaptic activity, allowing it to interact with DNCL1.
T5658	19141-19142	.	denotes	.
T5657	19135-19141	NN	denotes	HOMER3
T5656	19132-19134	IN	denotes	to
T5655	19124-19131	VBG	denotes	binding
T5654	19121-19123	IN	denotes	by
T5653	19117-19120	NN	denotes	PSD
T5652	19113-19116	DT	denotes	the
T5651	19110-19112	IN	denotes	in
T5650	19095-19097	VBZ	denotes	is
T5649	19090-19094	NN	denotes	PAX6
T5648	19098-19109	VBN	denotes	sequestered
T5647	19085-19089	IN	denotes	that
T5646	19077-19084	VBP	denotes	propose
T5645	19074-19076	PRP	denotes	We
T5644	19073-19142	sentence	denotes	We propose that PAX6 is sequestered in the PSD by binding to HOMER3.
T5643	19072-19073	.	denotes	.
T5642	19062-19072	NN	denotes	expression
T5641	19057-19061	NN	denotes	gene
T5640	19054-19056	IN	denotes	in
T5639	19046-19053	NNS	denotes	changes
T5638	19028-19038	NN	denotes	signalling
T5637	19019-19027	JJ	denotes	synaptic
T5636	19013-19018	WDT	denotes	which
T5635	19039-19045	VBZ	denotes	causes
T5634	19010-19012	IN	denotes	by
T5633	19000-19009	NN	denotes	mechanism
T5632	18998-18999	DT	denotes	a
T5631	18995-18997	IN	denotes	of
T5630	18989-18994	NN	denotes	basis
T5629	18985-18988	DT	denotes	the
T5628	18978-18981	MD	denotes	may
T5627	18972-18977	NN	denotes	DNCL1
T5626	18968-18971	CC	denotes	and
T5625	18961-18967	NN	denotes	HOMER3
T5624	18956-18960	IN	denotes	with
T5623	18951-18955	NN	denotes	PAX6
T5622	18948-18950	IN	denotes	of
T5621	18936-18947	NN	denotes	interaction
T5620	18932-18935	DT	denotes	the
T5619	18982-18984	VB	denotes	be
T5618	18927-18931	IN	denotes	that
T5617	18917-18926	VB	denotes	speculate
T5616	18914-18916	TO	denotes	to
T5615	18902-18913	JJ	denotes	interesting
T5614	18896-18898	PRP	denotes	it
T5613	18899-18901	VBZ	denotes	is
T5612	18888-18895	RB	denotes	However
T5611	18887-19073	sentence	denotes	However it is interesting to speculate that the interaction of PAX6 with HOMER3 and DNCL1 may be the basis of a mechanism by which synaptic signalling causes changes in gene expression.
T5610	18886-18887	.	denotes	.
T5609	18872-18877	JJ	denotes	other
T5608	18878-18886	NN	denotes	approach
T5607	18868-18871	DT	denotes	any
T5571	18656-18662	VBZ	denotes	lowers
T5570	18649-18655	NN	denotes	TRIM11
T5569	18648-18764	sentence	denotes	TRIM11 lowers Humanin levels by a mechanism that appears to involve ubiqutin-mediated proteasomal degradation [46].
T5568	18647-18648	.	denotes	.
T5567	18646-18647	-RRB-	denotes	]
T5566	18644-18646	CD	denotes	46
T5565	18643-18644	-LRB-	denotes	[
T5564	18632-18634	POS	denotes	's
T5563	18635-18642	NN	denotes	disease
T5562	18623-18632	NNP	denotes	Alzheimer
T5561	18618-18622	IN	denotes	with
T5560	18607-18617	VBN	denotes	associated
T5559	18593-18606	NN	denotes	neurotoxicity
T5558	18589-18592	DT	denotes	the
T5557	18578-18588	VBZ	denotes	suppresses
T5556	18573-18577	WDT	denotes	that
T5555	18565-18572	NN	denotes	protein
T5554	18563-18564	DT	denotes	a
T5553	18561-18563	,	denotes	,
T5552	18554-18561	NN	denotes	Humanin
T5551	18549-18553	IN	denotes	with
T5550	18539-18548	VBZ	denotes	interacts
T5549	18532-18538	NN	denotes	TRIM11
T5548	18531-18648	sentence	denotes	TRIM11 interacts with Humanin, a protein that suppresses the neurotoxicity associated with Alzheimer's disease [46].
T5547	18530-18531	.	denotes	.
T5546	18529-18530	-RRB-	denotes	]
T5545	18527-18529	CD	denotes	38
T5544	18526-18527	-LRB-	denotes	[
T5543	18512-18516	NN	denotes	TRIM
T5542	18517-18525	NN	denotes	proteins
T5541	18508-18511	DT	denotes	all
T5540	18504-18507	RB	denotes	not
T5539	18500-18503	CC	denotes	but
T5538	18495-18499	JJ	denotes	many
T5537	18492-18494	IN	denotes	in
T5536	18483-18485	VBZ	denotes	is
T5535	18486-18491	VBN	denotes	found
T5534	18478-18482	WDT	denotes	that
T5533	18465-18470	NN	denotes	B30.2
T5532	18471-18477	NN	denotes	domain
T5531	18463-18464	DT	denotes	a
T5530	18455-18459	RB	denotes	well
T5529	18460-18462	IN	denotes	as
T5528	18452-18454	RB	denotes	as
T5527	18450-18452	,	denotes	,
T5526	18439-18443	NN	denotes	coil
T5525	18432-18438	VBN	denotes	coiled
T5524	18444-18450	NN	denotes	domain
T5523	18430-18431	DT	denotes	a
T5522	18426-18429	CC	denotes	and
T5521	18424-18426	,	denotes	,
T5520	18413-18417	NN	denotes	zinc
T5519	18408-18409	HYPH	denotes	-
T5518	18409-18412	NN	denotes	box
T5517	18407-18408	NN	denotes	B
T5516	18418-18424	NN	denotes	finger
T5515	18405-18406	DT	denotes	a
T5514	18403-18405	,	denotes	,
T5513	18392-18396	NN	denotes	RING
T5512	18397-18403	NN	denotes	finger
T5511	18390-18391	DT	denotes	a
T5510	18388-18390	,	denotes	,
T5509	18374-18381	NN	denotes	protein
T5508	18382-18388	NN	denotes	family
T5507	18369-18373	DT	denotes	this
T5506	18366-18368	IN	denotes	of
T5505	18348-18358	JJ	denotes	structural
T5504	18333-18347	JJ	denotes	characteristic
T5503	18327-18332	CD	denotes	three
T5502	18359-18365	NNS	denotes	motifs
T5501	18323-18326	DT	denotes	the
T5500	18314-18322	VBZ	denotes	contains
T5499	18310-18313	CC	denotes	and
T5498	18308-18310	,	denotes	,
T5497	18307-18308	-RRB-	denotes	)
T5496	18296-18300	NN	denotes	RBCC
T5495	18301-18307	NN	denotes	family
T5494	18292-18295	DT	denotes	the
T5493	18289-18291	IN	denotes	as
T5492	18283-18288	VBN	denotes	known
T5491	18278-18282	RB	denotes	also
T5490	18277-18278	-LRB-	denotes	(
T5489	18262-18269	NN	denotes	protein
T5488	18256-18261	NN	denotes	motif
T5487	18245-18255	JJ	denotes	tripartite
T5486	18239-18244	NN	denotes	mouse
T5485	18270-18276	NN	denotes	family
T5484	18235-18238	DT	denotes	the
T5483	18232-18234	IN	denotes	of
T5482	18225-18231	NN	denotes	member
T5481	18223-18224	DT	denotes	a
T5480	18220-18222	VBZ	denotes	is
T5479	18213-18219	NN	denotes	TRIM11
T5478	18212-18531	sentence	denotes	TRIM11 is a member of the mouse tripartite motif protein family (also known as the RBCC family), and contains the three characteristic structural motifs of this protein family, a RING finger, a B-box zinc finger, and a coiled coil domain, as well as a B30.2 domain that is found in many but not all TRIM proteins [38].
T5477	18211-18212	.	denotes	.
T5476	18210-18211	-RRB-	denotes	]
T5475	18208-18210	CD	denotes	45
T6257	22220-22226	NN	denotes	TRIM11
T6256	22236-22244	VB	denotes	interact
T6255	22215-22219	IN	denotes	that
T6254	22204-22214	NN	denotes	hypothesis
T6253	22200-22203	DT	denotes	the
T6252	22195-22199	IN	denotes	with
T6251	22184-22194	JJ	denotes	consistent
T6250	22180-22183	VBP	denotes	are
T6249	22171-22174	PRP$	denotes	our
T6248	22175-22179	NNS	denotes	data
T6247	22167-22170	PDT	denotes	All
T6246	22166-22359	sentence	denotes	All our data are consistent with the hypothesis that TRIM11 does not interact with the C-terminal peptide, but interacts with the PST domain between the homeodomain and the C-terminal peptide.
T6245	22165-22166	.	denotes	.
T6244	22155-22158	NN	denotes	PST
T6243	22159-22165	NN	denotes	domain
T6242	22151-22154	DT	denotes	the
T6241	22148-22150	IN	denotes	of
T6240	22133-22134	HYPH	denotes	-
T6239	22132-22133	NN	denotes	N
T6238	22134-22142	JJ	denotes	terminal
T6237	22127-22131	RBR	denotes	more
T6236	22143-22147	NN	denotes	part
T6235	22123-22126	DT	denotes	the
T6234	22120-22122	IN	denotes	of
T6233	22107-22119	NN	denotes	conformation
T6232	22103-22106	DT	denotes	the
T6231	22093-22096	RB	denotes	not
T6230	22090-22092	VBP	denotes	do
T6229	22085-22089	PRP	denotes	they
T5474	18207-18208	-LRB-	denotes	[
T5473	18192-18197	NN	denotes	oxide
T5472	18185-18191	JJ	denotes	nitric
T5471	18198-18206	NN	denotes	synthase
T5470	18176-18184	JJ	denotes	neuronal
T5469	18172-18175	CC	denotes	and
T5468	18170-18171	-RRB-	denotes	]
T5467	18168-18170	CD	denotes	44
T5466	18167-18168	-LRB-	denotes	[
T5465	18147-18148	HYPH	denotes	-
T5464	18148-18158	VBN	denotes	associated
T5463	18141-18147	NN	denotes	domain
T5462	18134-18140	NN	denotes	kinase
T5461	18159-18166	NN	denotes	protein
T5460	18124-18133	NN	denotes	guanylate
T5459	18114-18123	VBG	denotes	including
T5458	18105-18113	NN	denotes	proteins
T5457	18101-18104	NN	denotes	PSD
T5456	18098-18100	IN	denotes	of
T5455	18090-18097	NN	denotes	variety
T5454	18088-18089	DT	denotes	a
T5453	18085-18087	IN	denotes	to
T5452	18079-18084	VBZ	denotes	binds
T5451	18073-18078	NN	denotes	DNCL1
T5450	18069-18072	CC	denotes	and
T5449	18067-18069	,	denotes	,
T5448	18066-18067	-RRB-	denotes	]
T5447	18064-18066	CD	denotes	43
T5446	18063-18064	-LRB-	denotes	[
T5445	18059-18062	NN	denotes	PSD
T5444	18055-18058	DT	denotes	the
T5443	18052-18054	IN	denotes	in
T5442	18040-18042	VBZ	denotes	is
T5441	18043-18051	VBN	denotes	enriched
T5440	18037-18039	NN	denotes	Va
T5439	18030-18036	NN	denotes	Myosin
T5438	18029-18212	sentence	denotes	Myosin Va is enriched in the PSD [43], and DNCL1 binds to a variety of PSD proteins including guanylate kinase domain-associated protein [44] and neuronal nitric oxide synthase [45].
T5437	18028-18029	.	denotes	.
T5436	18027-18028	-RRB-	denotes	]
T5435	18024-18025	,	denotes	,
T5434	18022-18024	CD	denotes	36
T5433	18025-18027	CD	denotes	37
T5432	18021-18022	-LRB-	denotes	[
T5431	18013-18020	NNS	denotes	neurons
T5430	18010-18012	IN	denotes	in
T5429	18001-18009	NNS	denotes	vesicles
T5428	17997-18000	CC	denotes	and
T5427	17986-17996	NNS	denotes	organelles
T5426	17984-17986	,	denotes	,
T5425	17976-17984	NN	denotes	proteins
T5424	17973-17975	IN	denotes	of
T5423	17960-17972	RB	denotes	respectively
T5422	17944-17945	HYPH	denotes	-
T5421	17945-17950	VBN	denotes	based
T5420	17939-17944	NN	denotes	actin
T5419	17935-17938	CC	denotes	and
T5418	17928-17929	HYPH	denotes	-
T5417	17929-17934	VBN	denotes	based
T5416	17917-17928	NN	denotes	microtubule
T5415	17951-17959	NN	denotes	movement
T5414	17913-17916	DT	denotes	the
T5413	17910-17912	IN	denotes	in
T5412	17897-17900	VBP	denotes	are
T5411	17894-17896	NN	denotes	Va
T5410	17887-17893	NN	denotes	myosin
T5409	17883-17886	CC	denotes	and
T5408	17901-17909	VBN	denotes	involved
T5407	17876-17882	NN	denotes	Dynein
T5406	17875-18029	sentence	denotes	Dynein and myosin Va are involved in the microtubule-based and actin-based movement respectively of proteins, organelles and vesicles in neurons [36,37].
T5405	17874-17875	.	denotes	.
T5404	17873-17874	-RRB-	denotes	]
T5403	17871-17873	CD	denotes	36
T5402	17870-17871	-LRB-	denotes	[
T5401	17867-17869	NN	denotes	Va
T5400	17860-17866	NN	denotes	myosin
T5399	17856-17859	CC	denotes	and
T5398	17849-17855	NN	denotes	dynein
T5397	17847-17849	,	denotes	,
T5396	17830-17837	NN	denotes	protein
T5395	17820-17829	NN	denotes	transport
T5394	17806-17819	JJ	denotes	intracellular
T5393	17838-17847	NNS	denotes	complexes
T5392	17802-17805	CD	denotes	two
T5391	17799-17801	IN	denotes	of
T5390	17791-17798	NN	denotes	subunit
T5389	17789-17790	DT	denotes	a
T5388	17786-17788	VBZ	denotes	is
T5387	17780-17785	NN	denotes	DNCL1
T5386	17779-17875	sentence	denotes	DNCL1 is a subunit of two intracellular transport protein complexes, dynein and myosin Va [36].
T5385	17778-17779	.	denotes	.
T5384	17777-17778	-RRB-	denotes	]
T5383	17775-17777	CD	denotes	42
T5382	17774-17775	-LRB-	denotes	[
T5381	17762-17773	NN	denotes	development
T5380	17756-17761	NN	denotes	brain
T5379	17749-17755	IN	denotes	during
T5378	17740-17748	NN	denotes	guidance
T5377	17735-17739	NN	denotes	axon
T5376	17732-17734	IN	denotes	in
T5375	17716-17720	VBN	denotes	been
T5374	17711-17715	RB	denotes	also
T5373	17706-17710	VBP	denotes	have
T5372	17721-17731	VBN	denotes	implicated
T5371	17697-17705	NN	denotes	proteins
T5370	17691-17696	NN	denotes	HOMER
T5369	17690-17779	sentence	denotes	HOMER proteins have also been implicated in axon guidance during brain development [42].
T5368	17689-17690	.	denotes	.
T5367	17688-17689	-RRB-	denotes	]
T5366	17686-17688	CD	denotes	41
T5365	17685-17686	SYM	denotes	-
T5364	17683-17685	CD	denotes	39
T5363	17682-17683	,	denotes	,
T5362	17680-17682	CD	denotes	35
T5361	17679-17680	-LRB-	denotes	[
T5360	17658-17669	NN	denotes	scaffolding
T5359	17670-17678	NN	denotes	proteins
T5358	17654-17657	NN	denotes	PSD
T5357	17650-17653	CC	denotes	and
T5356	17640-17649	NNS	denotes	receptors
T5281	17220-17430	sentence	denotes	HOMER3 is found in the PSD of neurons and directly binds to type I metabotropic glutamate receptors, which act via phospholipase C to stimulate IP3-mediated release of Ca2+ from intracellular vesicles [35,39].
T5280	17219-17220	.	denotes	.
T5279	17202-17203	HYPH	denotes	-
T5278	17203-17211	JJ	denotes	terminal
T5277	17201-17202	NN	denotes	C
T5276	17212-17219	NN	denotes	peptide
T5275	17197-17200	DT	denotes	the
T5274	17189-17196	VBG	denotes	lacking
T5273	17172-17178	NN	denotes	domain
T5272	17168-17171	NN	denotes	PST
T5271	17179-17188	NN	denotes	construct
T5270	17166-17167	DT	denotes	a
T5269	17161-17165	IN	denotes	with
T5268	17148-17151	RB	denotes	not
T5267	17144-17147	VBD	denotes	did
T5266	17138-17143	NN	denotes	DNCL1
T5265	17134-17137	CC	denotes	and
T5264	17127-17133	NN	denotes	HOMER3
T5263	17152-17160	VB	denotes	interact
T5262	17119-17126	IN	denotes	because
T5261	17100-17101	HYPH	denotes	/
T5260	17101-17106	NN	denotes	DNCL1
T5259	17096-17100	NN	denotes	PAX6
T5258	17093-17095	CC	denotes	or
T5257	17107-17118	NN	denotes	interaction
T5256	17085-17086	HYPH	denotes	/
T5255	17086-17092	NN	denotes	HOMER3
T5254	17081-17085	NN	denotes	PAX6
T5253	17077-17080	IN	denotes	for
T5252	17067-17076	JJ	denotes	important
T5251	17045-17046	HYPH	denotes	-
T5250	17046-17054	JJ	denotes	terminal
T5249	17044-17045	NN	denotes	C
T5248	17055-17062	NN	denotes	peptide
T5247	17040-17043	DT	denotes	the
T5246	17063-17066	VBD	denotes	was
T5245	17035-17039	IN	denotes	that
T5244	17028-17034	VBD	denotes	showed
T5243	17025-17027	PRP	denotes	we
T5242	17021-17024	CC	denotes	but
T5241	17019-17021	,	denotes	,
T5240	17014-17019	NNS	denotes	tests
T5239	17005-17013	JJ	denotes	pairwise
T5238	17002-17004	IN	denotes	in
T5237	16984-16991	NN	denotes	peptide
T5236	16974-16975	HYPH	denotes	-
T5235	16975-16983	JJ	denotes	terminal
T5234	16973-16974	NN	denotes	C
T5233	16992-17001	NN	denotes	construct
T5232	16969-16972	DT	denotes	the
T5231	16964-16968	IN	denotes	with
T5230	16958-16963	NN	denotes	DNCL1
T5229	16955-16957	CC	denotes	or
T5228	16948-16954	NN	denotes	HOMER3
T5227	16940-16947	IN	denotes	between
T5226	16928-16939	NN	denotes	interaction
T5225	16924-16927	DT	denotes	the
T5224	16916-16923	VB	denotes	confirm
T5223	16913-16915	TO	denotes	to
T5222	16908-16912	JJ	denotes	able
T5221	16904-16907	RB	denotes	not
T5220	16899-16903	VBD	denotes	were
T5219	16896-16898	PRP	denotes	We
T5218	16895-17220	sentence	denotes	We were not able to confirm the interaction between HOMER3 or DNCL1 with the C-terminal peptide construct in pairwise tests, but we showed that the C-terminal peptide was important for PAX6/HOMER3 or PAX6/DNCL1 interaction because HOMER3 and DNCL1 did not interact with a PST domain construct lacking the C-terminal peptide.
T5217	16894-16895	.	denotes	.
T5216	16889-16894	NNS	denotes	tests
T5215	16880-16888	JJ	denotes	pairwise
T5214	16877-16879	IN	denotes	in
T5213	16862-16866	VBD	denotes	were
T5212	16855-16861	NN	denotes	TRIM11
T5211	16851-16854	CC	denotes	and
T5210	16845-16850	NN	denotes	DNCL1
T5209	16843-16845	,	denotes	,
T5208	16837-16843	NN	denotes	HOMER3
T5207	16833-16836	CC	denotes	and
T5206	16822-16825	NN	denotes	PST
T5205	16826-16832	NN	denotes	domain
T5204	16818-16821	DT	denotes	the
T5203	16810-16817	IN	denotes	between
T5202	16867-16876	VBN	denotes	confirmed
T5201	16797-16809	NNS	denotes	interactions
T5200	16793-16796	DT	denotes	The
T5199	16792-16895	sentence	denotes	The interactions between the PST domain and HOMER3, DNCL1 and TRIM11 were confirmed in pairwise tests.
T5198	16791-16792	.	denotes	.
T5197	16781-16784	NN	denotes	PST
T5196	16785-16791	NN	denotes	domain
T5195	16777-16780	DT	denotes	the
T5194	16774-16776	IN	denotes	of
T5193	16759-16760	HYPH	denotes	-
T5192	16758-16759	NN	denotes	N
T5191	16760-16768	JJ	denotes	terminal
T5190	16753-16757	RBR	denotes	more
T5189	16769-16773	NN	denotes	part
T5188	16751-16752	DT	denotes	a
T5187	16746-16750	IN	denotes	with
T5186	16729-16735	NN	denotes	TRIM11
T5185	16736-16745	VBZ	denotes	interacts
T5606	18865-18867	IN	denotes	by
T5605	18850-18854	VBN	denotes	been
T5604	18846-18849	RB	denotes	not
T5603	18841-18845	VBP	denotes	have
T5602	18828-18840	NNS	denotes	interactions
T5601	18824-18827	DT	denotes	the
T5600	18855-18864	VBN	denotes	confirmed
T5599	18816-18823	IN	denotes	because
T5598	18804-18815	JJ	denotes	preliminary
T5597	18790-18792	VB	denotes	be
T5596	18785-18789	MD	denotes	must
T5595	18780-18784	NNS	denotes	data
T5594	18776-18779	PRP$	denotes	our
T5593	18768-18775	JJ	denotes	present
T5592	18793-18803	VBN	denotes	considered
T5591	18765-18767	IN	denotes	At
T5590	18764-18887	sentence	denotes	At present our data must be considered preliminary because the interactions have not been confirmed by any other approach.
T5589	18763-18764	.	denotes	.
T5588	18762-18763	-RRB-	denotes	]
T5587	18760-18762	CD	denotes	46
T5586	18759-18760	-LRB-	denotes	[
T5585	18735-18746	JJ	denotes	proteasomal
T5584	18747-18758	NN	denotes	degradation
T5583	18725-18726	HYPH	denotes	-
T5582	18726-18734	VBN	denotes	mediated
T5581	18717-18725	NN	denotes	ubiqutin
T5580	18709-18716	VB	denotes	involve
T5579	18706-18708	TO	denotes	to
T5578	18698-18705	VBZ	denotes	appears
T5577	18693-18697	WDT	denotes	that
T5576	18683-18692	NN	denotes	mechanism
T5575	18681-18682	DT	denotes	a
T5574	18678-18680	IN	denotes	by
T5573	18671-18677	NNS	denotes	levels
T5572	18663-18670	NN	denotes	Humanin
T5184	16723-16728	IN	denotes	while
T5183	16705-16706	HYPH	denotes	-
T5182	16706-16714	JJ	denotes	terminal
T5181	16704-16705	NN	denotes	C
T5180	16715-16722	NN	denotes	peptide
T5179	16700-16703	DT	denotes	the
T5178	16695-16699	IN	denotes	with
T5177	16673-16685	RB	denotes	specifically
T5176	16667-16672	NN	denotes	DNCL1
T5175	16663-16666	CC	denotes	and
T5174	16656-16662	NN	denotes	HOMER3
T5173	16686-16694	VBP	denotes	interact
T5172	16651-16655	IN	denotes	that
T5171	16640-16650	VBG	denotes	suggesting
T5170	16638-16640	,	denotes	,
T5169	16628-16631	NN	denotes	PST
T5168	16632-16638	NN	denotes	domain
T5167	16624-16627	DT	denotes	the
T5166	16619-16623	IN	denotes	with
T5165	16614-16618	RB	denotes	only
T5164	16596-16602	NN	denotes	TRIM11
T5163	16603-16613	VBD	denotes	interacted
T5162	16590-16595	IN	denotes	while
T5161	16579-16582	NN	denotes	PST
T5160	16583-16589	NN	denotes	domain
T5159	16575-16578	DT	denotes	the
T5158	16571-16574	CC	denotes	and
T5157	16553-16554	HYPH	denotes	-
T5156	16554-16562	JJ	denotes	terminal
T5155	16552-16553	NN	denotes	C
T5154	16563-16570	NN	denotes	peptide
T5153	16548-16551	DT	denotes	the
T5152	16543-16547	IN	denotes	with
T5151	16526-16531	NN	denotes	DNCL1
T5150	16522-16525	CC	denotes	and
T5149	16515-16521	NN	denotes	HOMER3
T5148	16513-16515	,	denotes	,
T5147	16506-16513	NNS	denotes	screens
T5146	16498-16505	NN	denotes	library
T5145	16532-16542	VBD	denotes	interacted
T5144	16495-16497	IN	denotes	In
T5143	16494-16792	sentence	denotes	In library screens, HOMER3 and DNCL1 interacted with the C-terminal peptide and the PST domain while TRIM11 interacted only with the PST domain, suggesting that HOMER3 and DNCL1 specifically interact with the C-terminal peptide while TRIM11 interacts with a more N-terminal part of the PST domain.
T5142	16493-16494	.	denotes	.
T5141	16487-16493	NN	denotes	TRIM11
T5140	16483-16486	CC	denotes	and
T5139	16477-16482	NN	denotes	DNCL1
T5138	16475-16477	,	denotes	,
T5137	16469-16475	NN	denotes	HOMER3
T5136	16467-16469	,	denotes	,
T5135	16447-16458	VBG	denotes	interacting
T5134	16441-16446	JJ	denotes	novel
T5133	16459-16467	NN	denotes	proteins
T5132	16435-16440	CD	denotes	three
T5131	16424-16434	VBD	denotes	identified
T5130	16421-16423	PRP	denotes	we
T5129	16417-16420	CC	denotes	and
T5128	16406-16409	NN	denotes	PST
T5127	16400-16405	JJ	denotes	whole
T5126	16410-16416	NN	denotes	domain
T5125	16396-16399	DT	denotes	the
T5124	16392-16395	CC	denotes	and
T5123	16374-16375	HYPH	denotes	-
T5122	16375-16383	JJ	denotes	terminal
T5121	16373-16374	NN	denotes	C
T5120	16384-16391	NN	denotes	peptide
T5119	16369-16372	DT	denotes	the
T5118	16364-16368	IN	denotes	with
T5117	16348-16355	NN	denotes	library
T5116	16340-16341	HYPH	denotes	-
T5115	16341-16347	NN	denotes	hybrid
T5114	16337-16340	CD	denotes	two
T5113	16356-16363	NNS	denotes	screens
T5112	16331-16336	NN	denotes	yeast
T5111	16321-16330	VBD	denotes	performed
T5110	16318-16320	PRP	denotes	We
T5109	16317-16494	sentence	denotes	We performed yeast two-hybrid library screens with the C-terminal peptide and the whole PST domain and we identified three novel interacting proteins, HOMER3, DNCL1 and TRIM11.
T5108	16316-16317	.	denotes	.
T5107	16299-16300	HYPH	denotes	-
T5106	16300-16308	JJ	denotes	terminal
T5105	16298-16299	NN	denotes	C
T5104	16309-16316	NN	denotes	peptide
T5103	16294-16297	DT	denotes	the
T5102	16282-16286	VBP	denotes	have
T5101	16279-16281	PRP	denotes	we
T5100	16287-16293	VBN	denotes	called
T5099	16273-16278	WDT	denotes	which
T5098	16271-16273	,	denotes	,
T5097	16257-16264	NN	denotes	protein
T5096	16252-16256	NN	denotes	PAX6
T5095	16246-16251	JJ	denotes	novel
T5094	16265-16271	NN	denotes	domain
T5093	16244-16245	DT	denotes	a
T5092	16233-16235	PRP	denotes	we
T5091	16231-16233	,	denotes	,
T5090	16210-16218	NN	denotes	sequence
T5089	16219-16231	NN	denotes	conservation
T5088	16205-16209	NN	denotes	acid
T5087	16199-16204	NN	denotes	amino
T5086	16195-16198	CC	denotes	and
T5085	16183-16194	NNS	denotes	predictions
T5084	16173-16182	NN	denotes	structure
T5083	16163-16172	JJ	denotes	secondary
T5082	16160-16162	IN	denotes	of
T5081	16154-16159	NN	denotes	basis
T5080	16150-16153	DT	denotes	the
T5079	16236-16243	VBD	denotes	defined
T5078	16147-16149	IN	denotes	On
T5355	17632-17639	JJ	denotes	various
T5354	17627-17631	IN	denotes	with
T5353	17621-17626	NNS	denotes	links
T5352	17609-17620	JJ	denotes	multivalent
T5351	17601-17608	VBG	denotes	forming
T5350	17598-17600	IN	denotes	by
T5349	17586-17597	NN	denotes	trafficking
T5348	17577-17585	NN	denotes	receptor
T5347	17573-17576	CC	denotes	and
T5346	17562-17572	NN	denotes	signalling
T5345	17548-17561	JJ	denotes	post-synaptic
T5344	17545-17547	IN	denotes	in
T5343	17540-17544	NN	denotes	role
T5342	17538-17539	DT	denotes	a
T5341	17533-17537	VBP	denotes	play
T5340	17529-17532	CC	denotes	and
T5339	17523-17528	NN	denotes	brain
T5338	17519-17522	DT	denotes	the
T5337	17516-17518	IN	denotes	in
T5336	17491-17505	RB	denotes	constitutively
T5335	17487-17490	VBP	denotes	are
T5334	17506-17515	VBN	denotes	expressed
T5333	17482-17486	WDT	denotes	that
T5332	17473-17481	NN	denotes	proteins
T5331	17470-17472	IN	denotes	of
T5330	17457-17462	NN	denotes	HOMER
T5329	17463-17469	NN	denotes	family
T5328	17453-17456	DT	denotes	the
T5327	17450-17452	IN	denotes	of
T5326	17443-17449	NN	denotes	member
T5325	17441-17442	DT	denotes	a
T5324	17438-17440	VBZ	denotes	is
T5323	17431-17437	NN	denotes	HOMER3
T5322	17430-17690	sentence	denotes	HOMER3 is a member of the HOMER family of proteins that are constitutively expressed in the brain and play a role in post-synaptic signalling and receptor trafficking by forming multivalent links with various receptors and PSD scaffolding proteins [35,39-41].
T5321	17429-17430	.	denotes	.
T5320	17428-17429	-RRB-	denotes	]
T5319	17425-17426	,	denotes	,
T5318	17423-17425	CD	denotes	35
T5317	17426-17428	CD	denotes	39
T5316	17422-17423	-LRB-	denotes	[
T5315	17413-17421	NNS	denotes	vesicles
T5314	17399-17412	JJ	denotes	intracellular
T5313	17394-17398	IN	denotes	from
T5312	17389-17393	NN	denotes	Ca2+
T5311	17386-17388	IN	denotes	of
T5310	17378-17385	NN	denotes	release
T5309	17368-17369	HYPH	denotes	-
T5308	17369-17377	VBN	denotes	mediated
T5307	17365-17368	NN	denotes	IP3
T5306	17355-17364	VB	denotes	stimulate
T5305	17352-17354	TO	denotes	to
T5304	17350-17351	NN	denotes	C
T5303	17336-17349	NN	denotes	phospholipase
T5302	17332-17335	IN	denotes	via
T5301	17328-17331	VBP	denotes	act
T5300	17322-17327	WDT	denotes	which
T5299	17320-17322	,	denotes	,
T5298	17301-17310	NN	denotes	glutamate
T5297	17288-17300	JJ	denotes	metabotropic
T5296	17286-17287	CD	denotes	I
T5295	17311-17320	NNS	denotes	receptors
T5294	17281-17285	NN	denotes	type
T5293	17278-17280	IN	denotes	to
T5292	17272-17277	VBZ	denotes	binds
T5291	17263-17271	RB	denotes	directly
T5290	17259-17262	CC	denotes	and
T5289	17251-17258	NNS	denotes	neurons
T5288	17248-17250	IN	denotes	of
T5287	17244-17247	NN	denotes	PSD
T5286	17240-17243	DT	denotes	the
T5285	17237-17239	IN	denotes	in
T5284	17228-17230	VBZ	denotes	is
T5283	17231-17236	VBN	denotes	found
T5282	17221-17227	NN	denotes	HOMER3
T4313	16133-16134	.	denotes	.
T4312	16123-16126	NN	denotes	PST
T4311	16127-16133	NN	denotes	domain
T4310	16119-16122	DT	denotes	the
T4309	16116-16118	IN	denotes	of
T4308	16101-16102	HYPH	denotes	-
T4307	16100-16101	NN	denotes	N
T4306	16102-16110	JJ	denotes	terminal
T4305	16095-16099	RBR	denotes	more
T4304	16111-16115	NN	denotes	part
T4303	16093-16094	DT	denotes	a
T4302	16088-16092	IN	denotes	with
T4301	16071-16077	NN	denotes	TRIM11
T4300	16078-16087	VBZ	denotes	interacts
T4299	16066-16070	IN	denotes	that
T4298	16055-16065	NN	denotes	hypothesis
T4297	16051-16054	DT	denotes	the
T4296	16046-16050	IN	denotes	with
T4295	16035-16045	JJ	denotes	consistent
T4294	16026-16031	RB	denotes	again
T4293	16032-16034	VBZ	denotes	is
T4292	16020-16025	WDT	denotes	which
T4291	16013-16019	NN	denotes	TRIM11
T4290	16008-16012	IN	denotes	with
T4289	15996-16007	NN	denotes	interaction
T4288	15992-15995	DT	denotes	the
T4287	15967-15972	CD	denotes	three
T4286	15973-15982	NNS	denotes	mutations
T4285	15963-15966	DT	denotes	the
T4284	15960-15962	IN	denotes	of
T4283	15983-15991	VBD	denotes	affected
T4282	15955-15959	NN	denotes	None
T4281	15954-16134	sentence	denotes	None of the three mutations affected the interaction with TRIM11 which again is consistent with the hypothesis that TRIM11 interacts with a more N-terminal part of the PST domain.
T4280	15953-15954	.	denotes	.
T4279	15952-15953	-RRB-	denotes	)
T4278	15951-15952	CD	denotes	1
T4277	15943-15945	,	denotes	,
T4276	15942-15943	CD	denotes	3
T4275	15935-15941	NN	denotes	Figure
T4274	15945-15950	NN	denotes	Table
T4273	15934-15935	-LRB-	denotes	(
T4067	14866-14870	VBN	denotes	been
T4066	14862-14865	VBZ	denotes	has
T4065	14860-14861	-RRB-	denotes	)
T4064	14855-14860	NN	denotes	X423L
T4063	14854-14855	-LRB-	denotes	(
T4062	14845-14853	NN	denotes	1629insT
T4061	14871-14879	VBN	denotes	reported
T4060	14830-14835	JJ	denotes	third
T4059	14836-14844	NN	denotes	mutation
T4058	14826-14829	DT	denotes	The
T4057	14825-14923	sentence	denotes	The third mutation 1629insT (X423L) has been reported in several aniridia patients [11,12,27,33].
T4056	14824-14825	.	denotes	.
T4055	14823-14824	-RRB-	denotes	]
T4054	14821-14823	CD	denotes	13
T4053	14820-14821	-LRB-	denotes	[
T4052	14804-14810	NN	denotes	corpus
T4051	14811-14819	NN	denotes	callosum
T4050	14800-14803	DT	denotes	the
T4049	14797-14799	IN	denotes	in
T4048	14788-14796	NNS	denotes	deficits
T4047	14781-14787	NN	denotes	matter
T4046	14775-14780	JJ	denotes	white
T4045	14771-14774	CC	denotes	and
T4044	14769-14771	,	denotes	,
T4043	14759-14769	NN	denotes	cerebellum
T4042	14755-14758	CC	denotes	and
T4041	14750-14754	NN	denotes	lobe
T4040	14741-14749	JJ	denotes	temporal
T4039	14739-14741	,	denotes	,
T4038	14727-14734	JJ	denotes	frontal
T4037	14735-14739	NN	denotes	lobe
T4036	14723-14726	DT	denotes	the
T4035	14720-14722	IN	denotes	in
T4034	14706-14719	NNS	denotes	abnormalities
T4033	14699-14705	NN	denotes	matter
T4032	14694-14698	JJ	denotes	grey
T4031	14685-14693	VBD	denotes	revealed
T4030	14676-14684	NN	denotes	analysis
T4029	14672-14675	NN	denotes	MRI
T4028	14671-14825	sentence	denotes	MRI analysis revealed grey matter abnormalities in the frontal lobe, temporal lobe and cerebellum, and white matter deficits in the corpus callosum [13].
T4027	14670-14671	.	denotes	.
T4026	14669-14670	-RRB-	denotes	]
T4025	14667-14669	CD	denotes	28
T4024	14666-14667	-LRB-	denotes	[
T4023	14648-14654	JJ	denotes	verbal
T4022	14655-14665	NN	denotes	inhibition
T4021	14643-14647	JJ	denotes	poor
T4020	14639-14642	CC	denotes	and
T4019	14622-14628	JJ	denotes	social
T4018	14629-14638	NN	denotes	cognition
T4017	14613-14621	VBN	denotes	impaired
T4016	14603-14612	VBG	denotes	including
T4015	14579-14595	JJ	denotes	neurobehavioural
T4014	14596-14602	NNS	denotes	traits
T4013	14571-14578	JJ	denotes	unusual
T4012	14557-14563	NN	denotes	family
T4011	14552-14556	DT	denotes	this
T4010	14549-14551	IN	denotes	in
T4009	14564-14570	VBD	denotes	showed
T4008	14537-14548	NNS	denotes	individuals
T4007	14528-14536	VBN	denotes	Affected
T4006	14527-14671	sentence	denotes	Affected individuals in this family showed unusual neurobehavioural traits including impaired social cognition and poor verbal inhibition [28].
T4005	14526-14527	.	denotes	.
T4004	14516-14517	HYPH	denotes	-
T4003	14506-14511	NN	denotes	amino
T4002	14512-14516	NN	denotes	acid
T4001	14502-14505	CD	denotes	103
T4000	14517-14526	NN	denotes	extension
T3999	14500-14501	DT	denotes	a
T3998	14497-14499	IN	denotes	by
T3997	14484-14487	VBP	denotes	are
T3996	14466-14467	HYPH	denotes	-
T3995	14467-14475	JJ	denotes	terminal
T3994	14465-14466	NN	denotes	C
T3993	14476-14483	NN	denotes	peptide
T3992	14461-14464	DT	denotes	the
T3991	14458-14460	IN	denotes	of
T3990	14446-14451	NN	denotes	amino
T3989	14444-14445	CD	denotes	5
T3988	14439-14443	JJ	denotes	last
T3987	14452-14457	NNS	denotes	acids
T3986	14435-14438	DT	denotes	the
T3985	14429-14434	WDT	denotes	which
T3984	14488-14496	VBN	denotes	replaced
T3983	14426-14428	IN	denotes	in
T3982	14418-14425	NN	denotes	protein
T3981	14416-14417	DT	denotes	a
T3980	14405-14415	VBG	denotes	generating
T3979	14403-14405	,	denotes	,
T3978	14384-14396	JJ	denotes	untranslated
T3977	14382-14383	SYM	denotes	'
T3976	14381-14382	CD	denotes	3
T3975	14397-14403	NN	denotes	region
T3974	14377-14380	DT	denotes	the
T3973	14372-14376	IN	denotes	into
T3972	14363-14364	HYPH	denotes	-
T3971	14359-14363	NN	denotes	read
T3970	14364-14371	NN	denotes	through
T3969	14345-14358	JJ	denotes	translational
T3968	14339-14344	VB	denotes	cause
T3967	14336-14338	TO	denotes	to
T3966	14326-14335	VBN	denotes	predicted
T3965	14323-14325	VBZ	denotes	is
T3964	14319-14322	CC	denotes	and
T3963	14308-14312	NN	denotes	stop
T3962	14303-14307	NN	denotes	PAX6
T3961	14313-14318	NN	denotes	codon
T3960	14299-14302	DT	denotes	the
T3959	14292-14298	IN	denotes	before
T3958	14287-14291	RB	denotes	just
T3957	14280-14286	VBZ	denotes	occurs
T3956	14261-14262	HYPH	denotes	-
T3955	14262-14270	VBG	denotes	shifting
T3954	14256-14261	NN	denotes	frame
T3953	14271-14279	NN	denotes	deletion
T3952	14251-14255	DT	denotes	This
T3951	14250-14527	sentence	denotes	This frame-shifting deletion occurs just before the PAX6 stop codon and is predicted to cause translational read-through into the 3' untranslated region, generating a protein in which the last 5 amino acids of the C-terminal peptide are replaced by a 103 amino acid-extension.
T3950	14249-14250	.	denotes	.
T3949	14248-14249	-RRB-	denotes	]
T3948	14246-14248	CD	denotes	28
T3947	14245-14246	-LRB-	denotes	[
T3946	14229-14237	NN	denotes	aniridia
T3945	14238-14244	NN	denotes	family
T3944	14226-14228	DT	denotes	an
T3943	14223-14225	IN	denotes	in
T3942	14213-14216	VBD	denotes	was
T3941	14211-14212	-RRB-	denotes	)
T3940	14202-14211	NN	denotes	1615del10
T3939	14201-14202	-LRB-	denotes	(
T3938	14217-14222	VBN	denotes	found
T3937	14185-14191	JJ	denotes	second
T3936	14192-14200	NN	denotes	mutation
T3935	14181-14184	DT	denotes	The
T3934	14180-14250	sentence	denotes	The second mutation (1615del10) was found in an aniridia family [28].
T3933	14179-14180	.	denotes	.
T3932	14178-14179	-RRB-	denotes	]
T3931	14175-14176	,	denotes	,
T3930	14173-14175	CD	denotes	27
T3929	14176-14178	CD	denotes	33
T3928	14172-14173	-LRB-	denotes	[
T3927	14161-14171	NN	denotes	hypoplasia
T3926	14154-14160	JJ	denotes	foveal
T3925	14150-14153	CC	denotes	and
T3924	14141-14149	NN	denotes	aniridia
T3923	14133-14140	JJ	denotes	typical
T3922	14128-14132	IN	denotes	with
T3921	14124-14127	CD	denotes	one
T3920	14120-14123	CC	denotes	and
T3919	14110-14119	NN	denotes	ectropion
T3918	14104-14109	JJ	denotes	uveal
T3917	14099-14103	IN	denotes	with
T3916	14080-14087	NN	denotes	segment
T3915	14088-14098	NN	denotes	dysgenesis
T3914	14071-14079	JJ	denotes	anterior
T3913	14068-14070	IN	denotes	by
T3912	14059-14067	VBN	denotes	affected
T3911	14055-14058	CD	denotes	one
T3910	14053-14055	,	denotes	,
T3909	14045-14053	NNS	denotes	patients
T3908	14041-14044	CD	denotes	two
T3907	14038-14040	IN	denotes	in
T3906	14024-14028	VBN	denotes	been
T3905	14020-14023	VBZ	denotes	has
T3904	14018-14019	-RRB-	denotes	)
T3903	14013-14018	NN	denotes	Q422R
T3902	14012-14013	-LRB-	denotes	(
T3901	14029-14037	VBN	denotes	reported
T3900	13994-14002	JJ	denotes	missense
T3899	14003-14011	NN	denotes	mutation
T3898	13989-13993	DT	denotes	This
T3897	13988-14180	sentence	denotes	This missense mutation (Q422R) has been reported in two patients, one affected by anterior segment dysgenesis with uveal ectropion and one with typical aniridia and foveal hypoplasia [27,33].
T3896	13987-13988	.	denotes	.
T3895	13983-13987	NN	denotes	PAX6
T3894	13980-13982	IN	denotes	of
T3893	13969-13973	JJ	denotes	last
T3892	13974-13979	NN	denotes	codon
T3891	13965-13968	DT	denotes	the
T3890	13962-13964	IN	denotes	in
T3889	13944-13948	NN	denotes	acid
T3888	13938-13943	NN	denotes	amino
T3887	13929-13937	NN	denotes	arginine
T3886	13926-13928	IN	denotes	to
T3885	13916-13925	NN	denotes	glutamine
T3884	13949-13961	NN	denotes	substitution
T3883	13914-13915	DT	denotes	a
T3882	13907-13913	VBZ	denotes	causes
T3881	13902-13906	WDT	denotes	that
T3880	13900-13901	NN	denotes	G
T3879	13899-13900	SYM	denotes	>
T3878	13894-13899	NN	denotes	1627A
T3877	13870-13880	NN	denotes	nucleotide
T3876	13863-13869	JJ	denotes	single
T3875	13881-13893	NN	denotes	substitution
T3874	13861-13862	DT	denotes	a
T3873	13858-13860	VBZ	denotes	is
T3872	13843-13848	JJ	denotes	first
T3871	13849-13857	NN	denotes	mutation
T3870	13839-13842	DT	denotes	The
T3869	13838-13988	sentence	denotes	The first mutation is a single nucleotide substitution 1627A>G that causes a glutamine to arginine amino acid substitution in the last codon of PAX6.
T3868	13837-13838	.	denotes	.
T3867	13828-13837	NNS	denotes	anomalies
T3866	13821-13827	JJ	denotes	ocular
T3865	13816-13820	IN	denotes	with
T3864	13807-13815	NNS	denotes	patients
T3863	13804-13806	IN	denotes	in
T3862	13783-13793	RB	denotes	previously
T3861	13778-13782	VBN	denotes	been
T3860	13773-13777	VBP	denotes	have
T3859	13794-13803	VBN	denotes	described
T3858	13768-13772	WDT	denotes	that
T3857	13753-13757	NN	denotes	PAX6
T3856	13743-13744	HYPH	denotes	-
T3855	13744-13752	JJ	denotes	terminal
T3854	13742-13743	NN	denotes	C
T3853	13758-13767	NNS	denotes	mutations
T3852	13736-13741	CD	denotes	three
T4272	15928-15933	NN	denotes	DNCL1
T4271	15924-15927	CC	denotes	and
T4270	15917-15923	NN	denotes	HOMER3
T4269	15912-15916	IN	denotes	with
T4268	15900-15911	NN	denotes	interaction
T4267	15896-15899	DT	denotes	the
T4266	15886-15895	VBD	denotes	abolished
T4265	15883-15885	CC	denotes	or
T4264	15862-15874	RB	denotes	dramatically
T4257	15808-15817	NN	denotes	extension
T4256	15798-15799	HYPH	denotes	-
T4255	15799-15807	JJ	denotes	terminal
T4254	15797-15798	NN	denotes	C
T4253	15828-15833	NN	denotes	X423L
T4252	15793-15796	DT	denotes	The
T4251	15792-15954	sentence	denotes	The C-terminal extension mutations X423L and1615del10 mutations both dramatically reduced or abolished the interaction with HOMER3 and DNCL1 (Figure 3, Table 1).
T4250	15791-15792	.	denotes	.
T4249	15790-15791	-RRB-	denotes	)
T4248	15789-15790	CD	denotes	1
T4247	15781-15783	,	denotes	,
T4246	15780-15781	CD	denotes	3
T4245	15773-15779	NN	denotes	Figure
T4244	15783-15788	NN	denotes	Table
T4243	15772-15773	-LRB-	denotes	(
T4242	15766-15771	NN	denotes	DNCL1
T4241	15762-15765	CC	denotes	and
T4240	15755-15761	NN	denotes	HOMER3
T4239	15750-15754	IN	denotes	with
T4238	15738-15749	NN	denotes	interaction
T4237	15734-15737	DT	denotes	the
T4236	15731-15733	IN	denotes	in
T4235	15721-15730	NN	denotes	reduction
T4234	15719-15720	DT	denotes	a
T4233	15710-15711	-RRB-	denotes	)
T4232	15705-15710	NN	denotes	Q422R
T4231	15704-15705	-LRB-	denotes	(
T4230	15712-15718	VBD	denotes	caused
T4229	15688-15694	JJ	denotes	subtle
T4228	15683-15687	RBS	denotes	most
T4227	15695-15703	NN	denotes	mutation
T4226	15679-15682	DT	denotes	The
T4225	15678-15792	sentence	denotes	The most subtle mutation (Q422R) caused a reduction in the interaction with HOMER3 and DNCL1 (Figure 3, Table 1).
T4224	15677-15678	.	denotes	.
T4223	15665-15677	NNS	denotes	interactions
T4222	15661-15664	DT	denotes	the
T4221	15658-15660	IN	denotes	on
T4220	15645-15650	JJ	denotes	clear
T4219	15651-15657	NN	denotes	effect
T4218	15643-15644	DT	denotes	a
T4217	15639-15642	VBD	denotes	had
T4216	15623-15628	CD	denotes	three
T4215	15629-15638	NNS	denotes	mutations
T4214	15619-15622	DT	denotes	All
T4213	15618-15678	sentence	denotes	All three mutations had a clear effect on the interactions.
T4212	15617-15618	.	denotes	.
T4211	15611-15617	NN	denotes	TRIM11
T4210	15607-15610	CC	denotes	and
T4209	15601-15606	NN	denotes	DNCL1
T4208	15599-15601	,	denotes	,
T4207	15593-15599	NN	denotes	HOMER3
T4206	15588-15592	IN	denotes	with
T4205	15573-15579	NN	denotes	mutant
T4204	15580-15587	NN	denotes	protein
T4203	15568-15572	DT	denotes	each
T4202	15565-15567	IN	denotes	of
T4201	15553-15564	NN	denotes	interaction
T4200	15549-15552	DT	denotes	the
T4199	15537-15548	VB	denotes	investigate
T4198	15534-15536	TO	denotes	to
T4197	15530-15533	RP	denotes	out
T4196	15517-15521	VBD	denotes	were
T4195	15522-15529	VBN	denotes	carried
T4194	15511-15516	NNS	denotes	tests
T4193	15502-15510	JJ	denotes	pairwise
T4192	15498-15501	CC	denotes	and
T4191	15496-15498	,	denotes	,
T4190	15479-15486	NN	denotes	PAX6PST
T4189	15487-15496	NN	denotes	construct
T4188	15475-15478	DT	denotes	the
T4187	15470-15474	IN	denotes	into
T4186	15454-15458	VBD	denotes	were
T4185	15459-15469	VBN	denotes	introduced
T4184	15438-15443	CD	denotes	three
T4183	15444-15453	NNS	denotes	mutations
T4182	15434-15437	DT	denotes	The
T4181	15433-15618	sentence	denotes	The three mutations were introduced into the PAX6PST construct, and pairwise tests were carried out to investigate the interaction of each mutant protein with HOMER3, DNCL1 and TRIM11.
T4180	15432-15433	.	denotes	.
T4179	15431-15432	-RRB-	denotes	]
T4178	15429-15431	CD	denotes	12
T4177	15428-15429	-LRB-	denotes	[
T4176	15419-15427	NN	denotes	epilepsy
T4175	15414-15418	IN	denotes	with
T4174	15402-15413	NN	denotes	association
T4173	15399-15401	IN	denotes	in
T4172	15393-15395	,	denotes	,
T4171	15379-15393	NN	denotes	polymicrogyria
T4170	15370-15378	JJ	denotes	temporal
T4169	15395-15398	CD	denotes	one
T4168	15366-15369	VBD	denotes	had
T4167	15357-15365	NNS	denotes	patients
T4166	15353-15356	CD	denotes	Two
T4165	15352-15433	sentence	denotes	Two patients had temporal polymicrogyria, one in association with epilepsy [12].
T4164	15351-15352	.	denotes	.
T4163	15350-15351	-RRB-	denotes	]
T4162	15348-15350	CD	denotes	12
T4161	15347-15348	-LRB-	denotes	[
T4160	15341-15346	NNS	denotes	bulbs
T4159	15331-15340	JJ	denotes	olfactory
T4158	15327-15330	CC	denotes	and
T4157	15321-15326	NN	denotes	gland
T4156	15314-15320	JJ	denotes	pineal
T4155	15312-15314	,	denotes	,
T4154	15293-15301	JJ	denotes	anterior
T4153	15302-15312	NN	denotes	commissure
T4152	15289-15292	DT	denotes	the
T4151	15286-15288	IN	denotes	of
T4150	15275-15285	NN	denotes	hypoplasia
T4149	15272-15274	CC	denotes	or
T4148	15264-15271	NN	denotes	absence
T4147	15254-15263	VBG	denotes	including
T4146	15240-15245	NN	denotes	brain
T4145	15246-15253	NNS	denotes	defects
T4144	15231-15239	JJ	denotes	variable
T4143	15213-15221	NN	denotes	mutation
T4142	15208-15212	DT	denotes	this
T4141	15203-15207	IN	denotes	with
T4140	15194-15202	NNS	denotes	patients
T4139	15190-15193	CD	denotes	six
T4138	15187-15189	IN	denotes	of
T4137	15222-15230	VBD	denotes	revealed
T4136	15178-15186	NN	denotes	analysis
T4135	15174-15177	NN	denotes	MRI
T4134	15173-15352	sentence	denotes	MRI analysis of six patients with this mutation revealed variable brain defects including absence or hypoplasia of the anterior commissure, pineal gland and olfactory bulbs [12].
T4133	15172-15173	.	denotes	.
T4132	15153-15165	JJ	denotes	untranslated
T4131	15151-15152	SYM	denotes	'
T4130	15150-15151	CD	denotes	3
T4129	15166-15172	NN	denotes	region
T4128	15146-15149	DT	denotes	the
T4127	15141-15145	IN	denotes	into
T4126	15129-15134	NN	denotes	amino
T4125	15126-15128	CD	denotes	35
T4124	15118-15125	JJ	denotes	further
T4123	15135-15140	NNS	denotes	acids
T4122	15116-15117	DT	denotes	a
T4121	15112-15115	IN	denotes	for
T4120	15104-15111	VBZ	denotes	extends
T4119	15099-15103	WDT	denotes	that
T4118	15079-15080	HYPH	denotes	-
T4117	15080-15088	JJ	denotes	terminal
T4116	15078-15079	NN	denotes	C
T4115	15089-15098	NN	denotes	extension
T4114	15076-15077	DT	denotes	a
T4113	15071-15075	IN	denotes	with
T4112	15058-15062	NN	denotes	PAX6
T4111	15051-15057	NN	denotes	length
T4110	15046-15050	JJ	denotes	full
T4109	15063-15070	NN	denotes	protein
T4108	15044-15045	DT	denotes	a
T4107	15034-15043	VBZ	denotes	generates
T4106	15030-15033	CC	denotes	and
T4105	15028-15029	-RRB-	denotes	)
T4104	15025-15028	NN	denotes	TTA
T4103	15024-15025	-LRB-	denotes	(
T4102	15010-15017	NN	denotes	leucine
T4101	15018-15023	NN	denotes	codon
T4100	15008-15009	DT	denotes	a
T4099	15005-15007	IN	denotes	to
T4098	15003-15004	-RRB-	denotes	)
T4097	15000-15003	NN	denotes	TAA
T4096	14999-15000	-LRB-	denotes	(
T4095	14988-14992	NN	denotes	stop
T4094	14993-14998	NN	denotes	codon
T4093	14984-14987	DT	denotes	the
T4092	14971-14975	CD	denotes	1629
T4091	14962-14970	NN	denotes	position
T4090	14959-14961	IN	denotes	at
T4089	14946-14947	NN	denotes	T
T4088	14939-14945	JJ	denotes	single
T4087	14948-14958	NN	denotes	nucleotide
T4086	14937-14938	DT	denotes	a
T4085	14934-14936	IN	denotes	of
T4084	14976-14983	VBZ	denotes	changes
T4083	14924-14933	NN	denotes	Insertion
T4082	14923-15173	sentence	denotes	Insertion of a single T nucleotide at position 1629 changes the stop codon (TAA) to a leucine codon (TTA) and generates a full length PAX6 protein with a C-terminal extension that extends for a further 35 amino acids into the 3' untranslated region.
T4081	14922-14923	.	denotes	.
T4080	14921-14922	-RRB-	denotes	]
T4079	14918-14919	,	denotes	,
T4078	14916-14918	CD	denotes	27
T4077	14915-14916	,	denotes	,
T4076	14913-14915	CD	denotes	12
T4075	14912-14913	,	denotes	,
T4074	14910-14912	CD	denotes	11
T4073	14919-14921	CD	denotes	33
T4072	14909-14910	-LRB-	denotes	[
T4071	14891-14899	NN	denotes	aniridia
T4070	14900-14908	NNS	denotes	patients
T4069	14883-14890	JJ	denotes	several
T4068	14880-14882	IN	denotes	in
T4263	15857-15861	DT	denotes	both
T4262	15847-15856	NNS	denotes	mutations
T4261	15837-15846	NN	denotes	1615del10
T4260	15834-15837	CC	denotes	and
T4259	15875-15882	VBD	denotes	reduced
T4258	15818-15827	NNS	denotes	mutations
T3851	13733-13735	IN	denotes	by
T3850	13719-13723	VBD	denotes	were
T3849	13706-13718	NNS	denotes	interactions
T3848	13702-13705	DT	denotes	the
T3847	13724-13732	VBN	denotes	affected
T3846	13698-13701	WRB	denotes	how
T3845	13680-13684	RB	denotes	next
T3844	13677-13679	PRP	denotes	we
T3843	13675-13677	,	denotes	,
T3842	13665-13668	NN	denotes	PST
T3841	13660-13664	NN	denotes	PAX6
T3840	13669-13675	NN	denotes	domain
T3839	13656-13659	DT	denotes	the
T3838	13651-13655	IN	denotes	with
T3837	13635-13641	NN	denotes	TRIM11
T3836	13631-13634	CC	denotes	and
T3835	13625-13630	NN	denotes	DNCL1
T834	11-14	DT	denotes	The
T835	20-27	NN	denotes	protein
T836	15-19	NN	denotes	PAX6
T837	28-30	VBZ	denotes	is
T838	31-32	DT	denotes	a
T839	33-39	NN	denotes	member
T840	40-42	IN	denotes	of
T841	43-46	DT	denotes	the
T842	64-70	NN	denotes	family
T843	47-50	NN	denotes	PAX
T844	51-52	-LRB-	denotes	(
T845	52-58	VBN	denotes	paired
T846	59-62	NN	denotes	box
T847	58-59	HYPH	denotes	-
T848	62-63	-RRB-	denotes	)
T849	71-73	IN	denotes	of
T850	74-89	JJ	denotes	transcriptional
T851	90-100	NNS	denotes	regulators
T852	101-104	CC	denotes	and
T853	105-107	VBZ	denotes	is
T854	108-117	JJ	denotes	essential
T855	118-121	IN	denotes	for
T856	122-128	JJ	denotes	normal
T857	147-158	NN	denotes	development
T858	129-135	JJ	denotes	ocular
T859	136-139	CC	denotes	and
T860	140-146	JJ	denotes	neural
T861	159-160	-LRB-	denotes	[
T862	160-161	CD	denotes	1
T863	161-162	-RRB-	denotes	]
T864	162-163	.	denotes	.
T865	163-301	sentence	denotes	Heterozygous mutations of the human PAX6 gene cause aniridia (absence of the iris) and a range of other congenital eye malformations [2].
T866	164-176	JJ	denotes	Heterozygous
T867	177-186	NNS	denotes	mutations
T868	210-215	VBP	denotes	cause
T869	187-189	IN	denotes	of
T870	190-193	DT	denotes	the
T871	205-209	NN	denotes	gene
T872	194-199	JJ	denotes	human
T873	200-204	NN	denotes	PAX6
T874	216-224	NN	denotes	aniridia
T875	225-226	-LRB-	denotes	(
T876	226-233	NN	denotes	absence
T877	234-236	IN	denotes	of
T878	237-240	DT	denotes	the
T879	241-245	NN	denotes	iris
T880	245-246	-RRB-	denotes	)
T881	247-250	CC	denotes	and
T882	251-252	DT	denotes	a
T883	253-258	NN	denotes	range
T884	259-261	IN	denotes	of
T885	262-267	JJ	denotes	other
T886	283-296	NNS	denotes	malformations
T887	268-278	JJ	denotes	congenital
T888	279-282	NN	denotes	eye
T889	297-298	-LRB-	denotes	[
T890	298-299	CD	denotes	2
T891	299-300	-RRB-	denotes	]
T892	300-301	.	denotes	.
T893	301-418	sentence	denotes	Neural defects such as foveal hypoplasia and optic nerve hypoplasia are common in PAX6-associated eye disease [3-5].
T894	302-308	JJ	denotes	Neural
T895	309-316	NNS	denotes	defects
T896	370-373	VBP	denotes	are
T897	317-321	JJ	denotes	such
T898	322-324	IN	denotes	as
T899	325-331	JJ	denotes	foveal
T900	332-342	NN	denotes	hypoplasia
T901	343-346	CC	denotes	and
T902	347-352	JJ	denotes	optic
T903	353-358	NN	denotes	nerve
T904	359-369	NN	denotes	hypoplasia
T905	374-380	JJ	denotes	common
T906	381-383	IN	denotes	in
T907	384-388	NN	denotes	PAX6
T908	389-399	VBN	denotes	associated
T909	388-389	HYPH	denotes	-
T910	404-411	NN	denotes	disease
T911	400-403	NN	denotes	eye
T912	412-413	-LRB-	denotes	[
T913	413-414	CD	denotes	3
T914	414-415	SYM	denotes	-
T915	415-416	CD	denotes	5
T916	416-417	-RRB-	denotes	]
T917	417-418	.	denotes	.
T918	418-622	sentence	denotes	Homozygous mutations in man and mouse are lethal and result in severe developmental abnormalities including anophthalmia, severe reduction of the olfactory structures and gross brain malformations [2,6].
T919	419-429	JJ	denotes	Homozygous
T920	430-439	NNS	denotes	mutations
T921	457-460	VBP	denotes	are
T922	440-442	IN	denotes	in
T923	443-446	NN	denotes	man
T924	447-450	CC	denotes	and
T925	451-456	NN	denotes	mouse
T926	461-467	JJ	denotes	lethal
T927	468-471	CC	denotes	and
T928	472-478	VBP	denotes	result
T929	479-481	IN	denotes	in
T930	482-488	JJ	denotes	severe
T931	503-516	NNS	denotes	abnormalities
T932	489-502	JJ	denotes	developmental
T933	517-526	VBG	denotes	including
T934	527-539	NN	denotes	anophthalmia
T935	539-541	,	denotes	,
T936	541-547	JJ	denotes	severe
T937	548-557	NN	denotes	reduction
T938	558-560	IN	denotes	of
T939	561-564	DT	denotes	the
T940	575-585	NNS	denotes	structures
T941	565-574	JJ	denotes	olfactory
T942	586-589	CC	denotes	and
T943	590-595	JJ	denotes	gross
T944	602-615	NNS	denotes	malformations
T945	596-601	NN	denotes	brain
T946	616-617	-LRB-	denotes	[
T947	619-620	CD	denotes	6
T948	617-618	CD	denotes	2
T949	618-619	,	denotes	,
T950	620-621	-RRB-	denotes	]
T951	621-622	.	denotes	.
T952	622-940	sentence	denotes	The roles of PAX6 in brain development have mainly been studied in homozygous mutant mice or rats and include arealisation of the cerebral cortex [7], formation of the prosencephalon-mesencephalon boundary [8], axon guidance [8], differentiation of neurons from glia [9] and neuronal migration in the cerebellum [10].
T953	623-626	DT	denotes	The
T954	627-632	NNS	denotes	roles
T955	679-686	VBN	denotes	studied
T956	633-635	IN	denotes	of
T957	636-640	NN	denotes	PAX6
T958	641-643	IN	denotes	in
T959	644-649	NN	denotes	brain
T960	650-661	NN	denotes	development
T961	662-666	VBP	denotes	have
T962	667-673	RB	denotes	mainly
T963	674-678	VBN	denotes	been
T964	687-689	IN	denotes	in
T965	690-700	JJ	denotes	homozygous
T966	708-712	NNS	denotes	mice
T967	701-707	NN	denotes	mutant
T968	713-715	CC	denotes	or
T969	716-720	NNS	denotes	rats
T970	721-724	CC	denotes	and
T971	725-732	VBP	denotes	include
T972	733-745	NN	denotes	arealisation
T973	746-748	IN	denotes	of
T974	749-752	DT	denotes	the
T975	762-768	NN	denotes	cortex
T976	753-761	JJ	denotes	cerebral
T977	769-770	-LRB-	denotes	[
T978	770-771	CD	denotes	7
T979	771-772	-RRB-	denotes	]
T980	772-774	,	denotes	,
T981	774-783	NN	denotes	formation
T982	784-786	IN	denotes	of
T983	787-790	DT	denotes	the
T984	820-828	NN	denotes	boundary
T985	791-805	NN	denotes	prosencephalon
T986	806-819	NN	denotes	mesencephalon
T987	805-806	HYPH	denotes	-
T988	829-830	-LRB-	denotes	[
T989	830-831	CD	denotes	8
T990	831-832	-RRB-	denotes	]
T991	832-834	,	denotes	,
T992	834-838	NN	denotes	axon
T993	839-847	NN	denotes	guidance
T994	848-849	-LRB-	denotes	[
T995	849-850	CD	denotes	8
T996	850-851	-RRB-	denotes	]
T997	851-853	,	denotes	,
T998	853-868	NN	denotes	differentiation
T999	869-871	IN	denotes	of
T1000	872-879	NNS	denotes	neurons
T1001	880-884	IN	denotes	from
T1002	885-889	NNS	denotes	glia
T1003	890-891	-LRB-	denotes	[
T1004	891-892	CD	denotes	9
T1005	892-893	-RRB-	denotes	]
T1006	894-897	CC	denotes	and
T1007	898-906	JJ	denotes	neuronal
T1008	907-916	NN	denotes	migration
T1009	917-919	IN	denotes	in
T1010	920-923	DT	denotes	the
T1011	924-934	NN	denotes	cerebellum
T1012	935-936	-LRB-	denotes	[
T1013	936-938	CD	denotes	10
T1014	938-939	-RRB-	denotes	]
T1015	939-940	.	denotes	.
T1016	940-1117	sentence	denotes	The discovery of multiple and diverse roles for PAX6 in brain development prompted MRI analyses of aniridia patients, and a range of distinctive brain anomalies were uncovered.
T1017	941-944	DT	denotes	The
T1018	945-954	NN	denotes	discovery
T1019	1015-1023	VBD	denotes	prompted
T1020	955-957	IN	denotes	of
T1021	958-966	JJ	denotes	multiple
T1022	979-984	NNS	denotes	roles
T1023	967-970	CC	denotes	and
T1024	971-978	JJ	denotes	diverse
T1025	985-988	IN	denotes	for
T1026	989-993	NN	denotes	PAX6
T1027	994-996	IN	denotes	in
T1028	997-1002	NN	denotes	brain
T1029	1003-1014	NN	denotes	development
T1030	1024-1027	NN	denotes	MRI
T1031	1028-1036	NNS	denotes	analyses
T1032	1037-1039	IN	denotes	of
T1033	1040-1048	NN	denotes	aniridia
T1034	1049-1057	NNS	denotes	patients
T1035	1057-1059	,	denotes	,
T1036	1059-1062	CC	denotes	and
T1037	1063-1064	DT	denotes	a
T1038	1065-1070	NN	denotes	range
T1039	1107-1116	VBN	denotes	uncovered
T1040	1071-1073	IN	denotes	of
T1041	1074-1085	JJ	denotes	distinctive
T1042	1092-1101	NNS	denotes	anomalies
T1043	1086-1091	NN	denotes	brain
T1044	1102-1106	VBD	denotes	were
T1045	1116-1117	.	denotes	.
T1046	1117-1214	sentence	denotes	The most common and striking of these was absence or hypoplasia of the anterior commissure [11].
T1047	1118-1121	DT	denotes	The
T1048	1127-1133	JJ	denotes	common
T1049	1122-1126	RBS	denotes	most
T1050	1156-1159	VBD	denotes	was
T1051	1134-1137	CC	denotes	and
T1052	1138-1146	JJ	denotes	striking
T1053	1147-1149	IN	denotes	of
T1054	1150-1155	DT	denotes	these
T1055	1160-1167	NN	denotes	absence
T1056	1168-1170	CC	denotes	or
T1057	1171-1181	NN	denotes	hypoplasia
T1058	1182-1184	IN	denotes	of
T1059	1185-1188	DT	denotes	the
T1060	1198-1208	NN	denotes	commissure
T1061	1189-1197	JJ	denotes	anterior
T1062	1209-1210	-LRB-	denotes	[
T1063	1210-1212	CD	denotes	11
T1064	1212-1213	-RRB-	denotes	]
T1065	1213-1214	.	denotes	.
T1066	1214-1400	sentence	denotes	Other defects included absence or hypoplasia of the pineal gland, cortical polymicrogyria, white matter changes in the corpus callosum and grey matter changes in the cerebellum [11-13].
T1067	1215-1220	JJ	denotes	Other
T1068	1221-1228	NNS	denotes	defects
T1069	1229-1237	VBD	denotes	included
T1070	1238-1245	NN	denotes	absence
T1071	1246-1248	CC	denotes	or
T1072	1249-1259	NN	denotes	hypoplasia
T1073	1260-1262	IN	denotes	of
T1074	1263-1266	DT	denotes	the
T1075	1274-1279	NN	denotes	gland
T1076	1267-1273	JJ	denotes	pineal
T1077	1279-1281	,	denotes	,
T1078	1281-1289	JJ	denotes	cortical
T1079	1290-1304	NN	denotes	polymicrogyria
T1080	1304-1306	,	denotes	,
T1081	1306-1311	JJ	denotes	white
T1082	1312-1318	NN	denotes	matter
T1083	1319-1326	NNS	denotes	changes
T1084	1327-1329	IN	denotes	in
T1085	1330-1333	DT	denotes	the
T1086	1341-1349	NN	denotes	callosum
T1087	1334-1340	NN	denotes	corpus
T1088	1350-1353	CC	denotes	and
T1089	1354-1358	JJ	denotes	grey
T1090	1359-1365	NN	denotes	matter
T1091	1366-1373	NNS	denotes	changes
T1092	1374-1376	IN	denotes	in
T1093	1377-1380	DT	denotes	the
T1094	1381-1391	NN	denotes	cerebellum
T1095	1392-1393	-LRB-	denotes	[
T1096	1393-1395	CD	denotes	11
T1097	1395-1396	SYM	denotes	-
T1098	1396-1398	CD	denotes	13
T1099	1398-1399	-RRB-	denotes	]
T1100	1399-1400	.	denotes	.
T1101	1400-1495	sentence	denotes	Functional changes included hyposmia and abnormal inter-hemispheric auditory transfer [11,14].
T1102	1401-1411	JJ	denotes	Functional
T1103	1412-1419	NNS	denotes	changes
T1104	1420-1428	VBD	denotes	included
T1105	1429-1437	NN	denotes	hyposmia
T1106	1438-1441	CC	denotes	and
T1107	1442-1450	JJ	denotes	abnormal
T1108	1478-1486	NN	denotes	transfer
T1109	1451-1468	JJ	denotes	inter-hemispheric
T1110	1469-1477	JJ	denotes	auditory
T1111	1487-1488	-LRB-	denotes	[
T1112	1491-1493	CD	denotes	14
T1113	1488-1490	CD	denotes	11
T1114	1490-1491	,	denotes	,
T1115	1493-1494	-RRB-	denotes	]
T1116	1494-1495	.	denotes	.
T1117	1495-1649	sentence	denotes	The defining feature of all PAX proteins is the presence of a 128 amino acid DNA-binding paired domain that has been highly conserved over evolution [1].
T1118	1496-1499	DT	denotes	The
T1119	1509-1516	NN	denotes	feature
T1120	1500-1508	VBG	denotes	defining
T1121	1537-1539	VBZ	denotes	is
T1122	1517-1519	IN	denotes	of
T1123	1520-1523	DT	denotes	all
T1124	1528-1536	NN	denotes	proteins
T1125	1524-1527	NN	denotes	PAX
T1126	1540-1543	DT	denotes	the
T1127	1544-1552	NN	denotes	presence
T1128	1553-1555	IN	denotes	of
T1129	1556-1557	DT	denotes	a
T1130	1592-1598	NN	denotes	domain
T1131	1558-1561	CD	denotes	128
T1132	1568-1572	NN	denotes	acid
T1133	1562-1567	NN	denotes	amino
T1134	1573-1576	NN	denotes	DNA
T1135	1577-1584	VBG	denotes	binding
T1136	1576-1577	HYPH	denotes	-
T1137	1585-1591	JJ	denotes	paired
T1138	1599-1603	WDT	denotes	that
T1139	1620-1629	VBN	denotes	conserved
T1140	1604-1607	VBZ	denotes	has
T1141	1608-1612	VBN	denotes	been
T1142	1613-1619	RB	denotes	highly
T1143	1630-1634	IN	denotes	over
T1144	1635-1644	NN	denotes	evolution
T1145	1645-1646	-LRB-	denotes	[
T1146	1646-1647	CD	denotes	1
T1147	1647-1648	-RRB-	denotes	]
T1148	1648-1649	.	denotes	.
T1149	1649-1807	sentence	denotes	In addition to the paired domain, PAX6 also contains a DNA-binding homeodomain and a proline, serine and threonine-rich (PST) domain at the C-terminus [1,6].
T1150	1650-1652	IN	denotes	In
T1151	1694-1702	VBZ	denotes	contains
T1152	1653-1661	NN	denotes	addition
T1153	1662-1664	IN	denotes	to
T1154	1665-1668	DT	denotes	the
T1155	1676-1682	NN	denotes	domain
T1156	1669-1675	JJ	denotes	paired
T1157	1682-1684	,	denotes	,
T1158	1684-1688	NN	denotes	PAX6
T1159	1689-1693	RB	denotes	also
T1160	1703-1704	DT	denotes	a
T1161	1717-1728	NN	denotes	homeodomain
T1162	1705-1708	NN	denotes	DNA
T1163	1709-1716	VBG	denotes	binding
T1164	1708-1709	HYPH	denotes	-
T1165	1729-1732	CC	denotes	and
T1166	1733-1734	DT	denotes	a
T1167	1776-1782	NN	denotes	domain
T1168	1735-1742	NN	denotes	proline
T1169	1765-1769	JJ	denotes	rich
T1170	1742-1744	,	denotes	,
T1171	1744-1750	NN	denotes	serine
T1172	1751-1754	CC	denotes	and
T1173	1755-1764	NN	denotes	threonine
T1174	1764-1765	HYPH	denotes	-
T1175	1770-1771	-LRB-	denotes	(
T1176	1771-1774	NN	denotes	PST
T1177	1774-1775	-RRB-	denotes	)
T1178	1783-1785	IN	denotes	at
T1179	1786-1789	DT	denotes	the
T1180	1792-1800	NN	denotes	terminus
T1181	1790-1791	NN	denotes	C
T1182	1791-1792	HYPH	denotes	-
T1183	1801-1802	-LRB-	denotes	[
T1184	1804-1805	CD	denotes	6
T1185	1802-1803	CD	denotes	1
T1186	1803-1804	,	denotes	,
T1187	1805-1806	-RRB-	denotes	]
T1188	1806-1807	.	denotes	.
T1189	1807-1939	sentence	denotes	The PST domain, which encompasses the C-terminal 145 amino acids of PAX6, has been shown to act as a transcriptional activator [6].
T1190	1808-1811	DT	denotes	The
T1191	1816-1822	NN	denotes	domain
T1192	1812-1815	NN	denotes	PST
T1193	1891-1896	VBN	denotes	shown
T1194	1822-1824	,	denotes	,
T1195	1824-1829	WDT	denotes	which
T1196	1830-1841	VBZ	denotes	encompasses
T1197	1842-1845	DT	denotes	the
T1198	1867-1872	NNS	denotes	acids
T1199	1846-1847	NN	denotes	C
T1200	1848-1856	JJ	denotes	terminal
T1201	1847-1848	HYPH	denotes	-
T1202	1857-1860	CD	denotes	145
T1203	1861-1866	NN	denotes	amino
T1204	1873-1875	IN	denotes	of
T1205	1876-1880	NN	denotes	PAX6
T1206	1880-1882	,	denotes	,
T1207	1882-1885	VBZ	denotes	has
T1208	1886-1890	VBN	denotes	been
T1209	1897-1899	TO	denotes	to
T1210	1900-1903	VB	denotes	act
T1211	1904-1906	IN	denotes	as
T1212	1907-1908	DT	denotes	a
T1213	1925-1934	NN	denotes	activator
T1214	1909-1924	JJ	denotes	transcriptional
T1215	1935-1936	-LRB-	denotes	[
T1216	1936-1937	CD	denotes	6
T1217	1937-1938	-RRB-	denotes	]
T1218	1938-1939	.	denotes	.
T1219	1939-2060	sentence	denotes	The PAX6 protein directly regulates a wide range of target genes [1,2] including Pax2 [15], Ngn2 [16] and glucagon [17].
T1220	1940-1943	DT	denotes	The
T1221	1949-1956	NN	denotes	protein
T1222	1944-1948	NN	denotes	PAX6
T1223	1966-1975	VBZ	denotes	regulates
T1224	1957-1965	RB	denotes	directly
T1225	1976-1977	DT	denotes	a
T1226	1983-1988	NN	denotes	range
T1227	1978-1982	JJ	denotes	wide
T1228	1989-1991	IN	denotes	of
T1229	1992-1998	NN	denotes	target
T1230	1999-2004	NNS	denotes	genes
T1231	2005-2006	-LRB-	denotes	[
T1232	2008-2009	CD	denotes	2
T1233	2006-2007	CD	denotes	1
T1234	2007-2008	,	denotes	,
T1235	2009-2010	-RRB-	denotes	]
T1236	2011-2020	VBG	denotes	including
T1237	2021-2025	NN	denotes	Pax2
T1238	2026-2027	-LRB-	denotes	[
T1239	2027-2029	CD	denotes	15
T1240	2029-2030	-RRB-	denotes	]
T1241	2030-2032	,	denotes	,
T1242	2032-2036	NN	denotes	Ngn2
T1243	2037-2038	-LRB-	denotes	[
T1244	2038-2040	CD	denotes	16
T1245	2040-2041	-RRB-	denotes	]
T1246	2042-2045	CC	denotes	and
T1247	2046-2054	NN	denotes	glucagon
T1248	2055-2056	-LRB-	denotes	[
T1249	2056-2058	CD	denotes	17
T1250	2058-2059	-RRB-	denotes	]
T1251	2059-2060	.	denotes	.
T1252	2060-2199	sentence	denotes	The Pax6 gene has a spatially and temporally complex expression pattern in the eye, brain, nasal structures, spinal cord and pancreas [1].
T1253	2061-2064	DT	denotes	The
T1254	2070-2074	NN	denotes	gene
T1255	2065-2069	NN	denotes	Pax6
T1256	2075-2078	VBZ	denotes	has
T1257	2079-2080	DT	denotes	a
T1258	2125-2132	NN	denotes	pattern
T1259	2081-2090	RB	denotes	spatially
T1260	2106-2113	JJ	denotes	complex
T1261	2091-2094	CC	denotes	and
T1262	2095-2105	RB	denotes	temporally
T1263	2114-2124	NN	denotes	expression
T1264	2133-2135	IN	denotes	in
T1265	2136-2139	DT	denotes	the
T1266	2140-2143	NN	denotes	eye
T1267	2143-2145	,	denotes	,
T1268	2145-2150	NN	denotes	brain
T1269	2150-2152	,	denotes	,
T1270	2152-2157	JJ	denotes	nasal
T1271	2158-2168	NNS	denotes	structures
T1272	2168-2170	,	denotes	,
T1273	2170-2176	JJ	denotes	spinal
T1274	2177-2181	NN	denotes	cord
T1275	2182-2185	CC	denotes	and
T1276	2186-2194	NN	denotes	pancreas
T1277	2195-2196	-LRB-	denotes	[
T1278	2196-2197	CD	denotes	1
T1279	2197-2198	-RRB-	denotes	]
T1280	2198-2199	.	denotes	.
T1281	2199-2348	sentence	denotes	Although PAX6 is clearly involved in multiple developmental processes, common themes are now emerging concerning the role of PAX6 in neural tissues.
T1282	2200-2208	IN	denotes	Although
T1283	2225-2233	VBN	denotes	involved
T1284	2209-2213	NN	denotes	PAX6
T1285	2214-2216	VBZ	denotes	is
T1286	2217-2224	RB	denotes	clearly
T1287	2293-2301	VBG	denotes	emerging
T1288	2234-2236	IN	denotes	in
T1289	2237-2245	JJ	denotes	multiple
T1290	2260-2269	NNS	denotes	processes
T1291	2246-2259	JJ	denotes	developmental
T1292	2269-2271	,	denotes	,
T1293	2271-2277	JJ	denotes	common
T1294	2278-2284	NNS	denotes	themes
T1295	2285-2288	VBP	denotes	are
T1296	2289-2292	RB	denotes	now
T1297	2302-2312	VBG	denotes	concerning
T1298	2313-2316	DT	denotes	the
T1299	2317-2321	NN	denotes	role
T1300	2322-2324	IN	denotes	of
T1301	2325-2329	NN	denotes	PAX6
T1302	2330-2332	IN	denotes	in
T1303	2333-2339	JJ	denotes	neural
T1304	2340-2347	NNS	denotes	tissues
T1305	2347-2348	.	denotes	.
T1306	2348-2476	sentence	denotes	Gradients of Pax6 expression are important for determining positional characteristics in the retina [18] and the neocortex [7].
T1307	2349-2358	NNS	denotes	Gradients
T1308	2378-2381	VBP	denotes	are
T1309	2359-2361	IN	denotes	of
T1310	2362-2366	NN	denotes	Pax6
T1311	2367-2377	NN	denotes	expression
T1312	2382-2391	JJ	denotes	important
T1313	2392-2395	IN	denotes	for
T1314	2396-2407	VBG	denotes	determining
T1315	2408-2418	JJ	denotes	positional
T1316	2419-2434	NNS	denotes	characteristics
T1317	2435-2437	IN	denotes	in
T1318	2438-2441	DT	denotes	the
T1319	2442-2448	NN	denotes	retina
T1320	2449-2450	-LRB-	denotes	[
T1321	2450-2452	CD	denotes	18
T1322	2452-2453	-RRB-	denotes	]
T1323	2454-2457	CC	denotes	and
T1324	2458-2461	DT	denotes	the
T1325	2462-2471	NN	denotes	neocortex
T1326	2472-2473	-LRB-	denotes	[
T1327	2473-2474	CD	denotes	7
T1328	2474-2475	-RRB-	denotes	]
T1329	2475-2476	.	denotes	.
T1330	2476-2611	sentence	denotes	PAX6 plays a role in development of specific axonal connections between the retina and the brain [18] and within the forebrain [8,19].
T1331	2477-2481	NN	denotes	PAX6
T1332	2482-2487	VBZ	denotes	plays
T1333	2488-2489	DT	denotes	a
T1334	2490-2494	NN	denotes	role
T1335	2495-2497	IN	denotes	in
T1336	2498-2509	NN	denotes	development
T1337	2510-2512	IN	denotes	of
T1338	2513-2521	JJ	denotes	specific
T1339	2529-2540	NNS	denotes	connections
T1340	2522-2528	JJ	denotes	axonal
T1341	2541-2548	IN	denotes	between
T1342	2549-2552	DT	denotes	the
T1343	2553-2559	NN	denotes	retina
T1344	2560-2563	CC	denotes	and
T1345	2564-2567	DT	denotes	the
T1346	2568-2573	NN	denotes	brain
T1347	2574-2575	-LRB-	denotes	[
T1348	2575-2577	CD	denotes	18
T1349	2577-2578	-RRB-	denotes	]
T1350	2579-2582	CC	denotes	and
T1351	2583-2589	IN	denotes	within
T1352	2590-2593	DT	denotes	the
T1353	2594-2603	NN	denotes	forebrain
T1354	2604-2605	-LRB-	denotes	[
T1355	2607-2609	CD	denotes	19
T1356	2605-2606	CD	denotes	8
T1357	2606-2607	,	denotes	,
T1358	2609-2610	-RRB-	denotes	]
T1359	2610-2611	.	denotes	.
T1360	2611-2807	sentence	denotes	It is also involved in the differentiation of neural cell types from multipotent precursors in the retina [16] and the cerebral cortex [9] through activation of bHLH genes such as Ngn2 and Mash1.
T1361	2612-2614	PRP	denotes	It
T1362	2623-2631	VBN	denotes	involved
T1363	2615-2617	VBZ	denotes	is
T1364	2618-2622	RB	denotes	also
T1365	2632-2634	IN	denotes	in
T1366	2635-2638	DT	denotes	the
T1367	2639-2654	NN	denotes	differentiation
T1368	2655-2657	IN	denotes	of
T1369	2658-2664	JJ	denotes	neural
T1370	2670-2675	NNS	denotes	types
T1371	2665-2669	NN	denotes	cell
T1372	2676-2680	IN	denotes	from
T1373	2681-2692	JJ	denotes	multipotent
T1374	2693-2703	NNS	denotes	precursors
T1375	2704-2706	IN	denotes	in
T1376	2707-2710	DT	denotes	the
T1377	2711-2717	NN	denotes	retina
T1378	2718-2719	-LRB-	denotes	[
T1379	2719-2721	CD	denotes	16
T1380	2721-2722	-RRB-	denotes	]
T1381	2723-2726	CC	denotes	and
T1382	2727-2730	DT	denotes	the
T1383	2740-2746	NN	denotes	cortex
T1384	2731-2739	JJ	denotes	cerebral
T1385	2747-2748	-LRB-	denotes	[
T1386	2748-2749	CD	denotes	9
T1387	2749-2750	-RRB-	denotes	]
T1388	2751-2758	IN	denotes	through
T1389	2759-2769	NN	denotes	activation
T1390	2770-2772	IN	denotes	of
T1391	2773-2777	NN	denotes	bHLH
T1392	2778-2783	NNS	denotes	genes
T1393	2784-2788	JJ	denotes	such
T1394	2789-2791	IN	denotes	as
T1395	2792-2796	NN	denotes	Ngn2
T1396	2797-2800	CC	denotes	and
T1397	2801-2806	NN	denotes	Mash1
T1398	2806-2807	.	denotes	.
T1399	2807-2992	sentence	denotes	These studies provide a clear link between PAX6 function in the retina and the brain, and are of particular relevance to the neurological phenotypes of individuals with PAX6 mutations.
T1400	2808-2813	DT	denotes	These
T1401	2814-2821	NNS	denotes	studies
T1402	2822-2829	VBP	denotes	provide
T1403	2830-2831	DT	denotes	a
T1404	2838-2842	NN	denotes	link
T1405	2832-2837	JJ	denotes	clear
T1406	2843-2850	IN	denotes	between
T1407	2851-2855	NN	denotes	PAX6
T1408	2856-2864	NN	denotes	function
T1409	2865-2867	IN	denotes	in
T1410	2868-2871	DT	denotes	the
T1411	2872-2878	NN	denotes	retina
T1412	2879-2882	CC	denotes	and
T1413	2883-2886	DT	denotes	the
T1414	2887-2892	NN	denotes	brain
T1415	2892-2894	,	denotes	,
T1416	2894-2897	CC	denotes	and
T1417	2898-2901	VBP	denotes	are
T1418	2902-2904	IN	denotes	of
T1419	2905-2915	JJ	denotes	particular
T1420	2916-2925	NN	denotes	relevance
T1421	2926-2928	IN	denotes	to
T1422	2929-2932	DT	denotes	the
T1423	2946-2956	NNS	denotes	phenotypes
T1424	2933-2945	JJ	denotes	neurological
T1425	2957-2959	IN	denotes	of
T1426	2960-2971	NNS	denotes	individuals
T1427	2972-2976	IN	denotes	with
T1428	2977-2981	NN	denotes	PAX6
T1429	2982-2991	NNS	denotes	mutations
T1430	2991-2992	.	denotes	.
T1431	2992-3158	sentence	denotes	It is becoming apparent that transcription factors do not act in isolation but are dependent on interactions with other proteins to carry out their function [20,21].
T1432	2993-2995	PRP	denotes	It
T1433	2999-3007	VBG	denotes	becoming
T1434	2996-2998	VBZ	denotes	is
T1435	3008-3016	JJ	denotes	apparent
T1436	3017-3021	IN	denotes	that
T1437	3051-3054	VB	denotes	act
T1438	3022-3035	NN	denotes	transcription
T1439	3036-3043	NNS	denotes	factors
T1440	3044-3046	VBP	denotes	do
T1441	3047-3050	RB	denotes	not
T1442	3055-3057	IN	denotes	in
T1443	3058-3067	NN	denotes	isolation
T1444	3068-3071	CC	denotes	but
T1445	3072-3075	VBP	denotes	are
T1446	3076-3085	JJ	denotes	dependent
T1447	3086-3088	IN	denotes	on
T1448	3089-3101	NNS	denotes	interactions
T1449	3102-3106	IN	denotes	with
T1450	3107-3112	JJ	denotes	other
T1451	3113-3121	NN	denotes	proteins
T1452	3122-3124	TO	denotes	to
T1453	3125-3130	VB	denotes	carry
T1454	3131-3134	RP	denotes	out
T1455	3135-3140	PRP$	denotes	their
T1456	3141-3149	NN	denotes	function
T1457	3150-3151	-LRB-	denotes	[
T1458	3154-3156	CD	denotes	21
T1459	3151-3153	CD	denotes	20
T1460	3153-3154	,	denotes	,
T1461	3156-3157	-RRB-	denotes	]
T1462	3157-3158	.	denotes	.
T1463	3158-3266	sentence	denotes	These interactions introduce more specificity into the regulatory function of a given transcription factor.
T1464	3159-3164	DT	denotes	These
T1465	3165-3177	NNS	denotes	interactions
T1466	3178-3187	VBP	denotes	introduce
T1467	3188-3192	JJR	denotes	more
T1468	3193-3204	NN	denotes	specificity
T1469	3205-3209	IN	denotes	into
T1470	3210-3213	DT	denotes	the
T1471	3225-3233	NN	denotes	function
T1472	3214-3224	JJ	denotes	regulatory
T1473	3234-3236	IN	denotes	of
T1474	3237-3238	DT	denotes	a
T1475	3259-3265	NN	denotes	factor
T1476	3239-3244	JJ	denotes	given
T1477	3245-3258	NN	denotes	transcription
T1478	3265-3266	.	denotes	.
T1479	3266-3616	sentence	denotes	To date only three PAX6 protein-protein interactions have been described: with SOX2 on the lens-specific enhancer element of the δ-crystallin gene [22]; with MDIA, which modulates PAX6 activity in early neuronal development [23], and with MAF proteins on the glucagon promoter, which causes increased expression of this pancreatic hormone gene [17].
T1480	3267-3269	IN	denotes	To
T1481	3330-3339	VBN	denotes	described
T1482	3270-3274	NN	denotes	date
T1483	3275-3279	RB	denotes	only
T1484	3307-3319	NNS	denotes	interactions
T1485	3280-3285	CD	denotes	three
T1486	3286-3290	NN	denotes	PAX6
T1487	3291-3298	NN	denotes	protein
T1488	3299-3306	NN	denotes	protein
T1489	3298-3299	SYM	denotes	-
T1490	3320-3324	VBP	denotes	have
T1491	3325-3329	VBN	denotes	been
T1492	3339-3341	:	denotes	:
T1493	3341-3345	IN	denotes	with
T1494	3346-3350	NN	denotes	SOX2
T1495	3351-3353	IN	denotes	on
T1496	3354-3357	DT	denotes	the
T1497	3381-3388	NN	denotes	element
T1498	3358-3362	NN	denotes	lens
T1499	3363-3371	JJ	denotes	specific
T1500	3362-3363	HYPH	denotes	-
T1501	3372-3380	NN	denotes	enhancer
T1502	3389-3391	IN	denotes	of
T1503	3392-3395	DT	denotes	the
T1504	3409-3413	NN	denotes	gene
T1505	3396-3397	SYM	denotes	δ
T1506	3398-3408	NN	denotes	crystallin
T1507	3397-3398	HYPH	denotes	-
T1508	3414-3415	-LRB-	denotes	[
T1509	3415-3417	CD	denotes	22
T1510	3417-3418	-RRB-	denotes	]
T1511	3418-3419	:	denotes	;
T1512	3420-3424	IN	denotes	with
T1513	3425-3429	NN	denotes	MDIA
T1514	3429-3431	,	denotes	,
T1515	3431-3436	WDT	denotes	which
T1516	3437-3446	VBZ	denotes	modulates
T1517	3447-3451	NN	denotes	PAX6
T1518	3452-3460	NN	denotes	activity
T1519	3461-3463	IN	denotes	in
T1520	3464-3469	JJ	denotes	early
T1521	3479-3490	NN	denotes	development
T1522	3470-3478	JJ	denotes	neuronal
T1523	3491-3492	-LRB-	denotes	[
T1524	3492-3494	CD	denotes	23
T1525	3494-3495	-RRB-	denotes	]
T1526	3495-3497	,	denotes	,
T1527	3497-3500	CC	denotes	and
T1528	3501-3505	IN	denotes	with
T1529	3506-3509	NN	denotes	MAF
T1530	3510-3518	NN	denotes	proteins
T1531	3519-3521	IN	denotes	on
T1532	3522-3525	DT	denotes	the
T1533	3535-3543	NN	denotes	promoter
T1534	3526-3534	NN	denotes	glucagon
T1535	3543-3545	,	denotes	,
T1536	3545-3550	WDT	denotes	which
T1537	3551-3557	VBZ	denotes	causes
T1538	3558-3567	VBN	denotes	increased
T1539	3568-3578	NN	denotes	expression
T1540	3579-3581	IN	denotes	of
T1541	3582-3586	DT	denotes	this
T1542	3606-3610	NN	denotes	gene
T1543	3587-3597	JJ	denotes	pancreatic
T1544	3598-3605	NN	denotes	hormone
T1545	3611-3612	-LRB-	denotes	[
T1546	3612-3614	CD	denotes	17
T1547	3614-3615	-RRB-	denotes	]
T1548	3615-3616	.	denotes	.
T1549	3616-3724	sentence	denotes	Here we report the preliminary results of the first systematic screen for proteins that interact with PAX6.
T1550	3617-3621	RB	denotes	Here
T1551	3625-3631	VBP	denotes	report
T1552	3622-3624	PRP	denotes	we
T1553	3632-3635	DT	denotes	the
T1554	3648-3655	NNS	denotes	results
T1555	3636-3647	JJ	denotes	preliminary
T1556	3656-3658	IN	denotes	of
T1557	3659-3662	DT	denotes	the
T1558	3680-3686	NN	denotes	screen
T1559	3663-3668	JJ	denotes	first
T1560	3669-3679	JJ	denotes	systematic
T1561	3687-3690	IN	denotes	for
T1562	3691-3699	NN	denotes	proteins
T1563	3700-3704	WDT	denotes	that
T1564	3705-3713	VBP	denotes	interact
T1565	3714-3718	IN	denotes	with
T1566	3719-3723	NN	denotes	PAX6
T1567	3723-3724	.	denotes	.
T1568	3724-3890	sentence	denotes	We used sequence alignment algorithms and secondary structure prediction programs to define a new domain of 32 amino acids at the C-terminal end of the PAX6 protein.
T1569	3725-3727	PRP	denotes	We
T1570	3728-3732	VBD	denotes	used
T1571	3733-3741	NN	denotes	sequence
T1572	3742-3751	NN	denotes	alignment
T1573	3752-3762	NNS	denotes	algorithms
T1574	3763-3766	CC	denotes	and
T1575	3767-3776	JJ	denotes	secondary
T1576	3777-3786	NN	denotes	structure
T1577	3787-3797	NN	denotes	prediction
T1578	3798-3806	NNS	denotes	programs
T1579	3807-3809	TO	denotes	to
T1580	3810-3816	VB	denotes	define
T1581	3817-3818	DT	denotes	a
T1582	3823-3829	NN	denotes	domain
T1583	3819-3822	JJ	denotes	new
T1584	3830-3832	IN	denotes	of
T1585	3833-3835	CD	denotes	32
T1586	3842-3847	NNS	denotes	acids
T1587	3836-3841	NN	denotes	amino
T1588	3848-3850	IN	denotes	at
T1589	3851-3854	DT	denotes	the
T1590	3866-3869	NN	denotes	end
T1591	3855-3856	NN	denotes	C
T1592	3857-3865	JJ	denotes	terminal
T1593	3856-3857	HYPH	denotes	-
T1594	3870-3872	IN	denotes	of
T1595	3873-3876	DT	denotes	the
T1596	3882-3889	NN	denotes	protein
T1597	3877-3881	NN	denotes	PAX6
T1598	3889-3890	.	denotes	.
T1599	3890-4053	sentence	denotes	We then screened a brain library with this peptide using the yeast two-hybrid technique and identified three novel interacting proteins, HOMER3, DNCL1 and TRIM11.
T1600	3891-3893	PRP	denotes	We
T1601	3899-3907	VBD	denotes	screened
T1602	3894-3898	RB	denotes	then
T1603	3908-3909	DT	denotes	a
T1604	3916-3923	NN	denotes	library
T1605	3910-3915	NN	denotes	brain
T1606	3924-3928	IN	denotes	with
T1607	3929-3933	DT	denotes	this
T1608	3934-3941	NN	denotes	peptide
T1609	3942-3947	VBG	denotes	using
T1610	3948-3951	DT	denotes	the
T1611	3969-3978	NN	denotes	technique
T1612	3952-3957	NN	denotes	yeast
T1613	3958-3961	CD	denotes	two
T1614	3962-3968	NN	denotes	hybrid
T1615	3961-3962	HYPH	denotes	-
T1616	3979-3982	CC	denotes	and
T1617	3983-3993	VBD	denotes	identified
T1618	3994-3999	CD	denotes	three
T1619	4018-4026	NN	denotes	proteins
T1620	4000-4005	JJ	denotes	novel
T1621	4006-4017	VBG	denotes	interacting
T1622	4026-4028	,	denotes	,
T1623	4028-4034	NN	denotes	HOMER3
T1624	4034-4036	,	denotes	,
T1625	4036-4041	NN	denotes	DNCL1
T1626	4042-4045	CC	denotes	and
T1627	4046-4052	NN	denotes	TRIM11
T1628	4052-4053	.	denotes	.
T1629	4053-4165	sentence	denotes	The interaction between PAX6 and these proteins was disrupted by naturally occurring C-terminal PAX6 mutations.
T1630	4054-4057	DT	denotes	The
T1631	4058-4069	NN	denotes	interaction
T1632	4106-4115	VBN	denotes	disrupted
T1633	4070-4077	IN	denotes	between
T1634	4078-4082	NN	denotes	PAX6
T1635	4083-4086	CC	denotes	and
T1636	4087-4092	DT	denotes	these
T1637	4093-4101	NN	denotes	proteins
T1638	4102-4105	VBD	denotes	was
T1639	4116-4118	IN	denotes	by
T1640	4119-4128	RB	denotes	naturally
T1641	4129-4138	VBG	denotes	occurring
T1642	4155-4164	NNS	denotes	mutations
T1643	4139-4140	NN	denotes	C
T1644	4141-4149	JJ	denotes	terminal
T1645	4140-4141	HYPH	denotes	-
T1646	4150-4154	NN	denotes	PAX6
T1647	4164-4165	.	denotes	.
T1765	4176-4177	DT	denotes	A
T1766	4211-4218	NN	denotes	peptide
T1767	4178-4184	RB	denotes	highly
T1768	4185-4194	JJ	denotes	conserved
T1769	4195-4196	NN	denotes	C
T1770	4197-4205	JJ	denotes	terminal
T1771	4196-4197	HYPH	denotes	-
T1772	4206-4210	NN	denotes	PAX6
T1773	4218-4337	sentence	denotes	We and others [31-33] noted that there is significant sequence conservation at the C-terminal end of the PAX6 protein.
T1774	4219-4221	PRP	denotes	We
T1775	4241-4246	VBD	denotes	noted
T1776	4222-4225	CC	denotes	and
T1777	4226-4232	NNS	denotes	others
T1778	4233-4234	-LRB-	denotes	[
T1779	4234-4236	CD	denotes	31
T1780	4236-4237	SYM	denotes	-
T1781	4237-4239	CD	denotes	33
T1782	4239-4240	-RRB-	denotes	]
T1783	4247-4251	IN	denotes	that
T1784	4258-4260	VBZ	denotes	is
T1785	4252-4257	EX	denotes	there
T1786	4261-4272	JJ	denotes	significant
T1787	4282-4294	NN	denotes	conservation
T1788	4273-4281	NN	denotes	sequence
T1789	4295-4297	IN	denotes	at
T1790	4298-4301	DT	denotes	the
T1791	4313-4316	NN	denotes	end
T1792	4302-4303	NN	denotes	C
T1793	4304-4312	JJ	denotes	terminal
T1794	4303-4304	HYPH	denotes	-
T1795	4317-4319	IN	denotes	of
T1796	4320-4323	DT	denotes	the
T1797	4329-4336	NN	denotes	protein
T1798	4324-4328	NN	denotes	PAX6
T1799	4336-4337	.	denotes	.
T1800	4337-4525	sentence	denotes	BLAST analysis of the amino acid sequence of the PAX6 PST domain (aa 278–422) revealed a highly conserved motif within the last 28 amino acids (beginning at the 'GLISP' motif, Figure 1a).
T1801	4338-4343	NN	denotes	BLAST
T1802	4344-4352	NN	denotes	analysis
T1803	4416-4424	VBD	denotes	revealed
T1804	4353-4355	IN	denotes	of
T1805	4356-4359	DT	denotes	the
T1806	4371-4379	NN	denotes	sequence
T1807	4360-4365	NN	denotes	amino
T1808	4366-4370	NN	denotes	acid
T1809	4380-4382	IN	denotes	of
T1810	4383-4386	DT	denotes	the
T1811	4396-4402	NN	denotes	domain
T1812	4387-4391	NN	denotes	PAX6
T1813	4392-4395	NN	denotes	PST
T1814	4403-4404	-LRB-	denotes	(
T1815	4407-4410	CD	denotes	278
T1816	4404-4406	NN	denotes	aa
T1817	4410-4411	SYM	denotes	–
T1818	4411-4414	CD	denotes	422
T1819	4414-4415	-RRB-	denotes	)
T1820	4425-4426	DT	denotes	a
T1821	4444-4449	NN	denotes	motif
T1822	4427-4433	RB	denotes	highly
T1823	4434-4443	JJ	denotes	conserved
T1824	4450-4456	IN	denotes	within
T1825	4457-4460	DT	denotes	the
T1826	4475-4480	NNS	denotes	acids
T1827	4461-4465	JJ	denotes	last
T1828	4466-4468	CD	denotes	28
T1829	4469-4474	NN	denotes	amino
T1830	4481-4482	-LRB-	denotes	(
T1831	4482-4491	VBG	denotes	beginning
T1832	4492-4494	IN	denotes	at
T1833	4495-4498	DT	denotes	the
T1834	4507-4512	NN	denotes	motif
T1835	4499-4500	``	denotes	'
T1836	4500-4505	NN	denotes	GLISP
T1837	4505-4506	''	denotes	'
T1838	4512-4514	,	denotes	,
T1839	4514-4520	NN	denotes	Figure
T1840	4521-4523	CD	denotes	1a
T1841	4523-4524	-RRB-	denotes	)
T1842	4524-4525	.	denotes	.
T1843	4525-4673	sentence	denotes	Strong conservation was seen in distantly related species such as axolotl (Ambystoma mexicanum) and sea urchin (Paracentrotus lividus) (Figure 1a).
T1844	4526-4532	JJ	denotes	Strong
T1845	4533-4545	NN	denotes	conservation
T1846	4550-4554	VBN	denotes	seen
T1847	4546-4549	VBD	denotes	was
T1848	4555-4557	IN	denotes	in
T1849	4558-4567	RB	denotes	distantly
T1850	4568-4575	VBN	denotes	related
T1851	4576-4583	NNS	denotes	species
T1852	4584-4588	JJ	denotes	such
T1853	4589-4591	IN	denotes	as
T1854	4592-4599	NN	denotes	axolotl
T1855	4600-4601	-LRB-	denotes	(
T1856	4601-4610	NNP	denotes	Ambystoma
T1857	4611-4620	NNP	denotes	mexicanum
T1858	4620-4621	-RRB-	denotes	)
T1859	4622-4625	CC	denotes	and
T1860	4626-4629	NN	denotes	sea
T1861	4630-4636	NN	denotes	urchin
T1862	4637-4638	-LRB-	denotes	(
T1863	4638-4651	NNP	denotes	Paracentrotus
T1880	5219-5228	JJ	denotes	secondary
T1881	5239-5247	NN	denotes	analysis
T1882	5229-5238	NN	denotes	structure
T1883	5248-5253	VBG	denotes	using
T1884	5254-5259	NNP	denotes	JPRED
T1885	5259-5261	,	denotes	,
T1886	5261-5262	DT	denotes	a
T1887	5263-5270	NN	denotes	program
T1888	5271-5275	WDT	denotes	that
T1889	5276-5280	VBZ	denotes	uses
T1890	5281-5282	DT	denotes	a
T1891	5283-5289	NN	denotes	number
T1892	5290-5292	IN	denotes	of
T1893	5293-5302	JJ	denotes	different
T1894	5332-5342	NNS	denotes	algorithms
T1895	5303-5310	NN	denotes	protein
T1896	5311-5320	NN	denotes	structure
T1897	5321-5331	NN	denotes	prediction
T1898	5343-5345	TO	denotes	to
T1899	5346-5354	VB	denotes	generate
T1900	5355-5356	DT	denotes	a
T1901	5377-5386	NN	denotes	structure
T1902	5357-5366	NN	denotes	consensus
T1903	5367-5376	JJ	denotes	secondary
T1904	5387-5388	-LRB-	denotes	(
T1905	5388-5394	NN	denotes	Figure
T1906	5395-5396	CD	denotes	1
T1907	5396-5397	-RRB-	denotes	)
T1908	5398-5399	-LRB-	denotes	[
T1909	5402-5404	CD	denotes	26
T1910	5399-5401	CD	denotes	25
T1911	5401-5402	,	denotes	,
T1912	5404-5405	-RRB-	denotes	]
T1913	5405-5406	.	denotes	.
T1914	5406-5686	sentence	denotes	The PST domain was largely devoid of predicted secondary structure except for the C-terminal region, which contained two predicted beta sheets within the highly conserved domain, one in the 'GLISP' motif and one in the 'SPVPQ' motif (identical to the pattern shown in Figure 1c).
T1915	5407-5410	DT	denotes	The
T1916	5415-5421	NN	denotes	domain
T1917	5411-5414	NN	denotes	PST
T1918	5422-5425	VBD	denotes	was
T1919	5426-5433	RB	denotes	largely
T1920	5434-5440	JJ	denotes	devoid
T1921	5441-5443	IN	denotes	of
T1922	5444-5453	VBN	denotes	predicted
T1923	5464-5473	NN	denotes	structure
T1924	5454-5463	JJ	denotes	secondary
T1925	5474-5480	IN	denotes	except
T1926	5481-5484	IN	denotes	for
T1927	5485-5488	DT	denotes	the
T1928	5500-5506	NN	denotes	region
T1929	5489-5490	NN	denotes	C
T1930	5491-5499	JJ	denotes	terminal
T1931	5490-5491	HYPH	denotes	-
T1932	5506-5508	,	denotes	,
T1933	5508-5513	WDT	denotes	which
T1934	5514-5523	VBD	denotes	contained
T1935	5524-5527	CD	denotes	two
T1936	5543-5549	NNS	denotes	sheets
T1937	5528-5537	VBN	denotes	predicted
T1938	5538-5542	NN	denotes	beta
T1939	5550-5556	IN	denotes	within
T1940	5557-5560	DT	denotes	the
T1941	5578-5584	NN	denotes	domain
T1942	5561-5567	RB	denotes	highly
T1943	5568-5577	JJ	denotes	conserved
T1944	5584-5586	,	denotes	,
T1945	5586-5589	CD	denotes	one
T1946	5590-5592	IN	denotes	in
T1947	5593-5596	DT	denotes	the
T1948	5598-5603	NN	denotes	GLISP
T1949	5597-5598	``	denotes	'
T1950	5605-5610	NN	denotes	motif
T1951	5603-5604	''	denotes	'
T1952	5611-5614	CC	denotes	and
T1953	5615-5618	CD	denotes	one
T1954	5619-5621	IN	denotes	in
T1955	5622-5625	DT	denotes	the
T1956	5627-5632	NN	denotes	SPVPQ
T1957	5626-5627	``	denotes	'
T1958	5634-5639	NN	denotes	motif
T1959	5632-5633	''	denotes	'
T1960	5640-5641	-LRB-	denotes	(
T1961	5641-5650	JJ	denotes	identical
T1962	5651-5653	IN	denotes	to
T1963	5654-5657	DT	denotes	the
T1964	5658-5665	NN	denotes	pattern
T1965	5666-5671	VBN	denotes	shown
T1966	5672-5674	IN	denotes	in
T1967	5675-5681	NN	denotes	Figure
T1968	5682-5684	CD	denotes	1c
T1969	5684-5685	-RRB-	denotes	)
T1970	5685-5686	.	denotes	.
T1971	5686-5892	sentence	denotes	Initially we defined the C-terminal domain as running from the 'GLISP' motif up to the stop codon, since this region was most highly conserved and contained strongly predicted secondary structure elements.
T1972	5687-5696	RB	denotes	Initially
T1973	5700-5707	VBD	denotes	defined
T1974	5697-5699	PRP	denotes	we
T1975	5708-5711	DT	denotes	the
T1976	5723-5729	NN	denotes	domain
T1977	5712-5713	NN	denotes	C
T1978	5714-5722	JJ	denotes	terminal
T1979	5713-5714	HYPH	denotes	-
T1980	5730-5732	IN	denotes	as
T1981	5733-5740	VBG	denotes	running
T1982	5741-5745	IN	denotes	from
T1983	5746-5749	DT	denotes	the
T1984	5751-5756	NN	denotes	GLISP
T1985	5750-5751	``	denotes	'
T1986	5758-5763	NN	denotes	motif
T1987	5756-5757	''	denotes	'
T1988	5764-5766	IN	denotes	up
T1989	5767-5769	IN	denotes	to
T1990	5770-5773	DT	denotes	the
T1991	5779-5784	NN	denotes	codon
T1992	5774-5778	NN	denotes	stop
T1993	5784-5786	,	denotes	,
T1994	5786-5791	IN	denotes	since
T1995	5820-5829	VBN	denotes	conserved
T1996	5792-5796	DT	denotes	this
T1997	5797-5803	NN	denotes	region
T1998	5804-5807	VBD	denotes	was
T1999	5808-5812	RBS	denotes	most
T2000	5813-5819	RB	denotes	highly
T2001	5830-5833	CC	denotes	and
T2002	5834-5843	VBD	denotes	contained
T2003	5844-5852	RB	denotes	strongly
T2004	5853-5862	VBN	denotes	predicted
T2005	5883-5891	NNS	denotes	elements
T2006	5863-5872	JJ	denotes	secondary
T2007	5873-5882	NN	denotes	structure
T2008	5891-5892	.	denotes	.
T2009	5892-6032	sentence	denotes	However when we performed secondary structure prediction analysis on this 28 amino acid peptide, the first beta sheet was lost (Figure 1b).
T2010	5893-5900	RB	denotes	However
T2011	6015-6019	VBN	denotes	lost
T2012	5901-5905	WRB	denotes	when
T2013	5909-5918	VBD	denotes	performed
T2014	5906-5908	PRP	denotes	we
T2015	5919-5928	JJ	denotes	secondary
T2016	5929-5938	NN	denotes	structure
T2017	5939-5949	NN	denotes	prediction
T2018	5950-5958	NN	denotes	analysis
T2019	5959-5961	IN	denotes	on
T2020	5962-5966	DT	denotes	this
T2021	5981-5988	NN	denotes	peptide
T2022	5967-5969	CD	denotes	28
T2023	5976-5980	NN	denotes	acid
T2024	5970-5975	NN	denotes	amino
T2025	5988-5990	,	denotes	,
T2026	5990-5993	DT	denotes	the
T2027	6005-6010	NN	denotes	sheet
T2028	5994-5999	JJ	denotes	first
T2029	6000-6004	NN	denotes	beta
T2030	6011-6014	VBD	denotes	was
T2031	6020-6021	-LRB-	denotes	(
T2032	6021-6027	NN	denotes	Figure
T2033	6028-6030	CD	denotes	1b
T2034	6030-6031	-RRB-	denotes	)
T2035	6031-6032	.	denotes	.
T2036	6032-6153	sentence	denotes	Addition of another 4 amino acids (TTST) immediately before 'GLISP' caused recovery of the first beta sheet (Figure 1c).
T2037	6033-6041	NN	denotes	Addition
T2038	6101-6107	VBN	denotes	caused
T2039	6042-6044	IN	denotes	of
T2040	6045-6052	DT	denotes	another
T2041	6061-6066	NNS	denotes	acids
T2042	6053-6054	CD	denotes	4
T2043	6055-6060	NN	denotes	amino
T2044	6067-6068	-LRB-	denotes	(
T2045	6068-6072	NN	denotes	TTST
T2046	6072-6073	-RRB-	denotes	)
T2047	6074-6085	RB	denotes	immediately
T2048	6086-6092	IN	denotes	before
T2049	6093-6094	``	denotes	'
T2050	6094-6099	NN	denotes	GLISP
T2051	6099-6100	''	denotes	'
T2052	6108-6116	NN	denotes	recovery
T2053	6117-6119	IN	denotes	of
T2054	6120-6123	DT	denotes	the
T2055	6135-6140	NN	denotes	sheet
T2056	6124-6129	JJ	denotes	first
T2057	6130-6134	NN	denotes	beta
T2058	6141-6142	-LRB-	denotes	(
T2059	6142-6148	NN	denotes	Figure
T2060	6149-6151	CD	denotes	1c
T2061	6151-6152	-RRB-	denotes	)
T2062	6152-6153	.	denotes	.
T2063	6153-6317	sentence	denotes	Although these 4 residues are not highly conserved (Figure 1a), they appear to be important for seeding the first beta sheet and therefore for secondary structure.
T2064	6154-6162	IN	denotes	Although
T2065	6180-6183	VBP	denotes	are
T2066	6163-6168	DT	denotes	these
T2067	6171-6179	NNS	denotes	residues
T2068	6169-6170	CD	denotes	4
T2069	6223-6229	VBP	denotes	appear
T2070	6184-6187	RB	denotes	not
T2071	6188-6194	RB	denotes	highly
T2072	6195-6204	VBN	denotes	conserved
T2073	6205-6206	-LRB-	denotes	(
T2074	6206-6212	NN	denotes	Figure
T2075	6213-6215	CD	denotes	1a
T2076	6215-6216	-RRB-	denotes	)
T2077	6216-6218	,	denotes	,
T2078	6218-6222	PRP	denotes	they
T2079	6230-6232	TO	denotes	to
T2080	6233-6235	VB	denotes	be
T2081	6236-6245	JJ	denotes	important
T2082	6246-6249	IN	denotes	for
T2083	6250-6257	VBG	denotes	seeding
T2084	6258-6261	DT	denotes	the
T2085	6273-6278	NN	denotes	sheet
T2086	6262-6267	JJ	denotes	first
T2087	6268-6272	NN	denotes	beta
T2088	6279-6282	CC	denotes	and
T2089	6283-6292	RB	denotes	therefore
T2090	6293-6296	IN	denotes	for
T2091	6297-6306	JJ	denotes	secondary
T2092	6307-6316	NN	denotes	structure
T2093	6316-6317	.	denotes	.
T2094	6317-6468	sentence	denotes	Thus we define the C-terminal peptide as being the final 32 amino acids of PAX6, running from threonine 391 to the stop codon (top line of Figure 1c).
T2095	6318-6322	RB	denotes	Thus
T2096	6326-6332	VBP	denotes	define
T2097	6323-6325	PRP	denotes	we
T2098	6333-6336	DT	denotes	the
T2099	6348-6355	NN	denotes	peptide
T2100	6337-6338	NN	denotes	C
T2101	6339-6347	JJ	denotes	terminal
T2102	6338-6339	HYPH	denotes	-
T2103	6356-6358	IN	denotes	as
T2104	6359-6364	VBG	denotes	being
T2105	6365-6368	DT	denotes	the
T2106	6384-6389	NNS	denotes	acids
T2107	6369-6374	JJ	denotes	final
T2108	6375-6377	CD	denotes	32
T2109	6378-6383	NN	denotes	amino
T2110	6390-6392	IN	denotes	of
T2111	6393-6397	NN	denotes	PAX6
T2112	6397-6399	,	denotes	,
T2113	6399-6406	VBG	denotes	running
T2114	6407-6411	IN	denotes	from
T2115	6412-6421	NN	denotes	threonine
T2116	6422-6425	CD	denotes	391
T2117	6426-6428	IN	denotes	to
T2118	6429-6432	DT	denotes	the
T2119	6438-6443	NN	denotes	codon
T2120	6433-6437	NN	denotes	stop
T2121	6444-6445	-LRB-	denotes	(
T2122	6449-6453	NN	denotes	line
T2123	6445-6448	NN	denotes	top
T2124	6454-6456	IN	denotes	of
T2125	6457-6463	NN	denotes	Figure
T2126	6464-6466	CD	denotes	1c
T2127	6466-6467	-RRB-	denotes	)
T2128	6467-6468	.	denotes	.
T2344	6470-6475	NN	denotes	Yeast
T2345	6487-6496	NN	denotes	screening
T2346	6476-6479	CD	denotes	two
T2347	6480-6486	NN	denotes	hybrid
T2348	6479-6480	HYPH	denotes	-
T2349	6496-6793	sentence	denotes	We hypothesised that the C-terminal peptide might be involved in protein-protein interactions, and we tested this by screening a cDNA library using the yeast two-hybrid system with a construct (PAX6CTP) in which the 32 amino acid C-terminal peptide was fused to the yeast GAL4 DNA binding domain.
T2350	6497-6499	PRP	denotes	We
T2351	6500-6512	VBD	denotes	hypothesised
T2352	6513-6517	IN	denotes	that
T2353	6550-6558	VBN	denotes	involved
T2354	6518-6521	DT	denotes	the
T2355	6533-6540	NN	denotes	peptide
T2356	6522-6523	NN	denotes	C
T2357	6524-6532	JJ	denotes	terminal
T2358	6523-6524	HYPH	denotes	-
T2359	6541-6546	MD	denotes	might
T2360	6547-6549	VB	denotes	be
T2361	6559-6561	IN	denotes	in
T2362	6562-6569	NN	denotes	protein
T2363	6570-6577	NN	denotes	protein
T2364	6569-6570	SYM	denotes	-
T2365	6578-6590	NNS	denotes	interactions
T2366	6590-6592	,	denotes	,
T2367	6592-6595	CC	denotes	and
T2368	6596-6598	PRP	denotes	we
T2369	6599-6605	VBD	denotes	tested
T2370	6606-6610	DT	denotes	this
T2371	6611-6613	IN	denotes	by
T2372	6614-6623	VBG	denotes	screening
T2373	6624-6625	DT	denotes	a
T2374	6631-6638	NN	denotes	library
T2375	6626-6630	NN	denotes	cDNA
T2376	6639-6644	VBG	denotes	using
T2377	6645-6648	DT	denotes	the
T2378	6666-6672	NN	denotes	system
T2379	6649-6654	NN	denotes	yeast
T2380	6655-6658	CD	denotes	two
T2381	6659-6665	NN	denotes	hybrid
T2382	6658-6659	HYPH	denotes	-
T2383	6673-6677	IN	denotes	with
T2384	6678-6679	DT	denotes	a
T2385	6680-6689	NN	denotes	construct
T2386	6690-6691	-LRB-	denotes	(
T2387	6691-6698	NN	denotes	PAX6CTP
T2388	6698-6699	-RRB-	denotes	)
T2389	6700-6702	IN	denotes	in
T2390	6750-6755	VBN	denotes	fused
T2391	6703-6708	WDT	denotes	which
T2392	6709-6712	DT	denotes	the
T2393	6738-6745	NN	denotes	peptide
T2394	6713-6715	CD	denotes	32
T2395	6722-6726	NN	denotes	acid
T2396	6716-6721	NN	denotes	amino
T2397	6727-6728	NN	denotes	C
T2398	6729-6737	JJ	denotes	terminal
T2399	6728-6729	HYPH	denotes	-
T2400	6746-6749	VBD	denotes	was
T2401	6756-6758	IN	denotes	to
T2402	6759-6762	DT	denotes	the
T2403	6786-6792	NN	denotes	domain
T2404	6763-6768	NN	denotes	yeast
T2405	6769-6773	NN	denotes	GAL4
T2406	6774-6777	NN	denotes	DNA
T2407	6778-6785	NN	denotes	binding
T2408	6792-6793	.	denotes	.
T2409	6793-6877	sentence	denotes	We chose to screen a mouse brain cDNA library as no human libraries were available.
T2410	6794-6796	PRP	denotes	We
T2411	6797-6802	VBD	denotes	chose
T2412	6803-6805	TO	denotes	to
T2413	6806-6812	VB	denotes	screen
T2414	6813-6814	DT	denotes	a
T2415	6832-6839	NN	denotes	library
T2416	6815-6820	NN	denotes	mouse
T2417	6821-6826	NN	denotes	brain
T2418	6827-6831	NN	denotes	cDNA
T2419	6840-6842	IN	denotes	as
T2420	6862-6866	VBD	denotes	were
T2421	6843-6845	DT	denotes	no
T2422	6852-6861	NNS	denotes	libraries
T2423	6846-6851	JJ	denotes	human
T2424	6867-6876	JJ	denotes	available
T2425	6876-6877	.	denotes	.
T2426	6877-7045	sentence	denotes	Given the fact that the amino acid sequence of the PAX6 protein is identical in man and mouse, we reasoned that a mouse brain library would yield relevant interactors.
T2427	6878-6883	VBN	denotes	Given
T2428	6976-6984	VBD	denotes	reasoned
T2429	6884-6887	DT	denotes	the
T2430	6888-6892	NN	denotes	fact
T2431	6893-6897	IN	denotes	that
T2432	6942-6944	VBZ	denotes	is
T2433	6898-6901	DT	denotes	the
T2434	6913-6921	NN	denotes	sequence
T2435	6902-6907	NN	denotes	amino
T2436	6908-6912	NN	denotes	acid
T2437	6922-6924	IN	denotes	of
T2438	6925-6928	DT	denotes	the
T2439	6934-6941	NN	denotes	protein
T2440	6929-6933	NN	denotes	PAX6
T2441	6945-6954	JJ	denotes	identical
T2442	6955-6957	IN	denotes	in
T2443	6958-6961	NN	denotes	man
T2444	6962-6965	CC	denotes	and
T2445	6966-6971	NN	denotes	mouse
T2446	6971-6973	,	denotes	,
T2447	6973-6975	PRP	denotes	we
T2448	6985-6989	IN	denotes	that
T2449	7018-7023	VB	denotes	yield
T2450	6990-6991	DT	denotes	a
T2451	7004-7011	NN	denotes	library
T2452	6992-6997	NN	denotes	mouse
T2453	6998-7003	NN	denotes	brain
T2454	7012-7017	MD	denotes	would
T2455	7024-7032	JJ	denotes	relevant
T2456	7033-7044	NNS	denotes	interactors
T2457	7044-7045	.	denotes	.
T2458	7045-7152	sentence	denotes	For comparison we also carried out the screen using a construct containing the whole PST domain (PAX6PST).
T2459	7046-7049	IN	denotes	For
T2460	7069-7076	VBD	denotes	carried
T2461	7050-7060	NN	denotes	comparison
T2462	7061-7063	PRP	denotes	we
T2463	7064-7068	RB	denotes	also
T2464	7077-7080	RP	denotes	out
T2465	7081-7084	DT	denotes	the
T2466	7085-7091	NN	denotes	screen
T2467	7092-7097	VBG	denotes	using
T2468	7098-7099	DT	denotes	a
T2469	7100-7109	NN	denotes	construct
T2470	7110-7120	VBG	denotes	containing
T2471	7121-7124	DT	denotes	the
T2472	7135-7141	NN	denotes	domain
T2473	7125-7130	JJ	denotes	whole
T2474	7131-7134	NN	denotes	PST
T2475	7142-7143	-LRB-	denotes	(
T2476	7143-7150	NN	denotes	PAX6PST
T2477	7150-7151	-RRB-	denotes	)
T2478	7151-7152	.	denotes	.
T2479	7152-7287	sentence	denotes	The C-terminal peptide screen gave 15 colonies that were positive with all three reporters and the PST domain screen gave 62 colonies.
T2480	7153-7156	DT	denotes	The
T2481	7176-7182	NN	denotes	screen
T2482	7157-7158	NN	denotes	C
T2483	7159-7167	JJ	denotes	terminal
T2484	7158-7159	HYPH	denotes	-
T2485	7168-7175	NN	denotes	peptide
T2486	7183-7187	VBD	denotes	gave
T2487	7188-7190	CD	denotes	15
T2488	7191-7199	NNS	denotes	colonies
T2489	7200-7204	WDT	denotes	that
T2490	7205-7209	VBD	denotes	were
T2491	7210-7218	JJ	denotes	positive
T2492	7219-7223	IN	denotes	with
T2493	7224-7227	DT	denotes	all
T2494	7234-7243	NNS	denotes	reporters
T2495	7228-7233	CD	denotes	three
T2496	7244-7247	CC	denotes	and
T2497	7248-7251	DT	denotes	the
T2498	7263-7269	NN	denotes	screen
T2499	7252-7255	NN	denotes	PST
T2500	7256-7262	NN	denotes	domain
T2501	7270-7274	VBD	denotes	gave
T2502	7275-7277	CD	denotes	62
T2503	7278-7286	NNS	denotes	colonies
T2504	7286-7287	.	denotes	.
T2505	7287-7358	sentence	denotes	The interacting plasmids were isolated and the cDNA inserts sequenced.
T2506	7288-7291	DT	denotes	The
T2507	7304-7312	NNS	denotes	plasmids
T2508	7292-7303	VBG	denotes	interacting
T2509	7318-7326	VBN	denotes	isolated
T2510	7313-7317	VBD	denotes	were
T2511	7327-7330	CC	denotes	and
T2512	7331-7334	DT	denotes	the
T2513	7340-7347	NNS	denotes	inserts
T2514	7335-7339	NN	denotes	cDNA
T2515	7348-7357	VBN	denotes	sequenced
T2516	7357-7358	.	denotes	.
T2517	7358-7569	sentence	denotes	Three cDNAs were identified 3 or more times, Homer3 (NM_011984), Dncl1 (Dynein cytoplasmic light chain 1, NM_019682, also known as Pin or Dlc8) and Trim11 (Tripartite motif protein family member 11, NM_053168).
T2518	7359-7364	CD	denotes	Three
T2519	7365-7370	NNS	denotes	cDNAs
T2520	7376-7386	VBN	denotes	identified
T2521	7371-7375	VBD	denotes	were
T2522	7387-7388	CD	denotes	3
T2523	7397-7402	NNS	denotes	times
T2524	7389-7391	CC	denotes	or
T2525	7392-7396	JJR	denotes	more
T2526	7402-7404	,	denotes	,
T2527	7404-7410	NN	denotes	Homer3
T2528	7411-7412	-LRB-	denotes	(
T2529	7412-7421	NN	denotes	NM_011984
T2530	7421-7422	-RRB-	denotes	)
T2531	7422-7424	,	denotes	,
T2532	7424-7429	NN	denotes	Dncl1
T2533	7430-7431	-LRB-	denotes	(
T2534	7431-7437	NNP	denotes	Dynein
T2535	7456-7461	NN	denotes	chain
T2536	7438-7449	JJ	denotes	cytoplasmic
T2537	7450-7455	JJ	denotes	light
T2538	7462-7463	CD	denotes	1
T2539	7463-7465	,	denotes	,
T2540	7465-7474	NN	denotes	NM_019682
T2541	7474-7476	,	denotes	,
T2542	7476-7480	RB	denotes	also
T2543	7481-7486	VBN	denotes	known
T2544	7487-7489	IN	denotes	as
T2545	7490-7493	NN	denotes	Pin
T2546	7494-7496	CC	denotes	or
T2547	7497-7501	NN	denotes	Dlc8
T2548	7501-7502	-RRB-	denotes	)
T2549	7503-7506	CC	denotes	and
T2550	7507-7513	NN	denotes	Trim11
T2551	7514-7515	-LRB-	denotes	(
T2552	7515-7525	JJ	denotes	Tripartite
T2553	7526-7531	NN	denotes	motif
T2554	7547-7553	NN	denotes	member
T2555	7532-7539	NN	denotes	protein
T2556	7540-7546	NN	denotes	family
T2557	7554-7556	CD	denotes	11
T2558	7556-7558	,	denotes	,
T2559	7558-7567	NN	denotes	NM_053168
T2560	7567-7568	-RRB-	denotes	)
T2561	7568-7569	.	denotes	.
T2562	7569-7658	sentence	denotes	Homer3 (6 clones) and Dncl1 (2 clones) were identified in the C-terminal peptide screen.
T2563	7570-7576	NN	denotes	Homer3
T2564	7614-7624	VBN	denotes	identified
T2565	7577-7578	-LRB-	denotes	(
T2566	7580-7586	NNS	denotes	clones
T2567	7578-7579	CD	denotes	6
T2568	7586-7587	-RRB-	denotes	)
T2569	7588-7591	CC	denotes	and
T2570	7592-7597	NN	denotes	Dncl1
T2571	7598-7599	-LRB-	denotes	(
T2572	7601-7607	NNS	denotes	clones
T2573	7599-7600	CD	denotes	2
T2574	7607-7608	-RRB-	denotes	)
T2575	7609-7613	VBD	denotes	were
T2576	7625-7627	IN	denotes	in
T2577	7628-7631	DT	denotes	the
T2578	7651-7657	NN	denotes	screen
T2579	7632-7633	NN	denotes	C
T2580	7634-7642	JJ	denotes	terminal
T2581	7633-7634	HYPH	denotes	-
T2582	7643-7650	NN	denotes	peptide
T2583	7657-7658	.	denotes	.
T2584	7658-7758	sentence	denotes	Homer3 (7 clones), Dncl1 (2 clones) and Trim11 (6 clones) were identified in the PST domain screen.
T2585	7659-7665	NN	denotes	Homer3
T2586	7722-7732	VBN	denotes	identified
T2587	7666-7667	-LRB-	denotes	(
T2588	7669-7675	NNS	denotes	clones
T2589	7667-7668	CD	denotes	7
T2590	7675-7676	-RRB-	denotes	)
T2591	7676-7678	,	denotes	,
T2592	7678-7683	NN	denotes	Dncl1
T2593	7684-7685	-LRB-	denotes	(
T2594	7687-7693	NNS	denotes	clones
T2595	7685-7686	CD	denotes	2
T2596	7693-7694	-RRB-	denotes	)
T2597	7695-7698	CC	denotes	and
T2598	7699-7705	NN	denotes	Trim11
T2599	7706-7707	-LRB-	denotes	(
T2600	7709-7715	NNS	denotes	clones
T2601	7707-7708	CD	denotes	6
T2602	7715-7716	-RRB-	denotes	)
T2603	7717-7721	VBD	denotes	were
T2604	7733-7735	IN	denotes	in
T2605	7736-7739	DT	denotes	the
T2606	7751-7757	NN	denotes	screen
T2607	7740-7743	NN	denotes	PST
T2608	7744-7750	NN	denotes	domain
T2609	7757-7758	.	denotes	.
T2610	7758-7849	sentence	denotes	All cDNA inserts were in-frame with the coding region of the pPC86 GAL4 activation domain.
T2611	7759-7762	DT	denotes	All
T2612	7768-7775	NNS	denotes	inserts
T2613	7763-7767	NN	denotes	cDNA
T2614	7776-7780	VBD	denotes	were
T2615	7781-7783	IN	denotes	in
T2616	7783-7784	HYPH	denotes	-
T2617	7784-7789	NN	denotes	frame
T2618	7790-7794	IN	denotes	with
T2619	7795-7798	DT	denotes	the
T2620	7806-7812	NN	denotes	region
T2621	7799-7805	NN	denotes	coding
T2622	7813-7815	IN	denotes	of
T2623	7816-7819	DT	denotes	the
T2624	7842-7848	NN	denotes	domain
T2625	7820-7825	NN	denotes	pPC86
T2626	7826-7830	NN	denotes	GAL4
T2627	7831-7841	NN	denotes	activation
T2628	7848-7849	.	denotes	.
T2629	7849-7920	sentence	denotes	None of the cDNAs was present in a list of known false positives [34].
T2630	7850-7854	NN	denotes	None
T2631	7868-7871	VBD	denotes	was
T2632	7855-7857	IN	denotes	of
T2633	7858-7861	DT	denotes	the
T2634	7862-7867	NNS	denotes	cDNAs
T2635	7872-7879	JJ	denotes	present
T2636	7880-7882	IN	denotes	in
T2637	7883-7884	DT	denotes	a
T2638	7885-7889	NN	denotes	list
T2639	7890-7892	IN	denotes	of
T2640	7893-7898	JJ	denotes	known
T2641	7905-7914	NNS	denotes	positives
T2642	7899-7904	JJ	denotes	false
T2643	7915-7916	-LRB-	denotes	[
T2644	7916-7918	CD	denotes	34
T2645	7918-7919	-RRB-	denotes	]
T2646	7919-7920	.	denotes	.
T2647	7920-8014	sentence	denotes	HOMER3 is a member of the HOMER family of neuronal post-synaptic density (PSD) proteins [35].
T2648	7921-7927	NN	denotes	HOMER3
T2649	7928-7930	VBZ	denotes	is
T2650	7931-7932	DT	denotes	a
T2651	7933-7939	NN	denotes	member
T2652	7940-7942	IN	denotes	of
T2653	7943-7946	DT	denotes	the
T2654	7953-7959	NN	denotes	family
T2655	7947-7952	NN	denotes	HOMER
T2656	7960-7962	IN	denotes	of
T2657	7963-7971	JJ	denotes	neuronal
T2658	8000-8008	NN	denotes	proteins
T2659	7972-7985	JJ	denotes	post-synaptic
T2660	7986-7993	NN	denotes	density
T2661	7994-7995	-LRB-	denotes	(
T2662	7995-7998	NN	denotes	PSD
T2663	7998-7999	-RRB-	denotes	)
T2664	8009-8010	-LRB-	denotes	[
T2665	8010-8012	CD	denotes	35
T2666	8012-8013	-RRB-	denotes	]
T2667	8013-8014	.	denotes	.
T2668	8014-8190	sentence	denotes	DNCL1 is a subunit of two motor protein complexes, dynein and myosin-Va, both of which are involved in intracellular trafficking of proteins and organelles in neurons [36,37].
T2669	8015-8020	NN	denotes	DNCL1
T2670	8021-8023	VBZ	denotes	is
T2671	8024-8025	DT	denotes	a
T2672	8026-8033	NN	denotes	subunit
T2673	8034-8036	IN	denotes	of
T2674	8037-8040	CD	denotes	two
T2675	8055-8064	NNS	denotes	complexes
T2676	8041-8046	NN	denotes	motor
T2677	8047-8054	NN	denotes	protein
T2678	8064-8066	,	denotes	,
T2679	8066-8072	NN	denotes	dynein
T2680	8073-8076	CC	denotes	and
T2681	8077-8083	NN	denotes	myosin
T2682	8084-8086	NN	denotes	Va
T2683	8083-8084	HYPH	denotes	-
T2684	8086-8088	,	denotes	,
T2685	8088-8092	DT	denotes	both
T2686	8106-8114	VBN	denotes	involved
T2687	8093-8095	IN	denotes	of
T2688	8096-8101	WDT	denotes	which
T2689	8102-8105	VBP	denotes	are
T2690	8115-8117	IN	denotes	in
T2691	8118-8131	JJ	denotes	intracellular
T2692	8132-8143	NN	denotes	trafficking
T2693	8144-8146	IN	denotes	of
T2694	8147-8155	NN	denotes	proteins
T2695	8156-8159	CC	denotes	and
T2696	8160-8170	NNS	denotes	organelles
T2697	8171-8173	IN	denotes	in
T2698	8174-8181	NNS	denotes	neurons
T2699	8182-8183	-LRB-	denotes	[
T2700	8186-8188	CD	denotes	37
T2701	8183-8185	CD	denotes	36
T2702	8185-8186	,	denotes	,
T2703	8188-8189	-RRB-	denotes	]
T2704	8189-8190	.	denotes	.
T2705	8190-8343	sentence	denotes	TRIM11 is a member of the tripartite motif protein family and contains a RING finger, a B-box zinc finger, a coiled coil domain and a B30.2 domain [38].
T2706	8191-8197	NN	denotes	TRIM11
T2707	8198-8200	VBZ	denotes	is
T2708	8201-8202	DT	denotes	a
T2709	8203-8209	NN	denotes	member
T2710	8210-8212	IN	denotes	of
T2711	8213-8216	DT	denotes	the
T2712	8242-8248	NN	denotes	family
T2713	8217-8227	JJ	denotes	tripartite
T2714	8228-8233	NN	denotes	motif
T2715	8234-8241	NN	denotes	protein
T2716	8249-8252	CC	denotes	and
T2717	8253-8261	VBZ	denotes	contains
T2718	8262-8263	DT	denotes	a
T2719	8269-8275	NN	denotes	finger
T2720	8264-8268	NN	denotes	RING
T2721	8275-8277	,	denotes	,
T2722	8277-8278	DT	denotes	a
T2723	8290-8296	NN	denotes	finger
T2724	8279-8280	NN	denotes	B
T2725	8281-8284	NN	denotes	box
T2726	8280-8281	HYPH	denotes	-
T2727	8285-8289	NN	denotes	zinc
T2728	8296-8298	,	denotes	,
T2729	8298-8299	DT	denotes	a
T2730	8312-8318	NN	denotes	domain
T2731	8300-8306	VBN	denotes	coiled
T2732	8307-8311	NN	denotes	coil
T2733	8319-8322	CC	denotes	and
T2734	8323-8324	DT	denotes	a
T2735	8331-8337	NN	denotes	domain
T2736	8325-8330	NN	denotes	B30.2
T2737	8338-8339	-LRB-	denotes	[
T2738	8339-8341	CD	denotes	38
T2739	8341-8342	-RRB-	denotes	]
T2740	8342-8343	.	denotes	.
T2741	8343-8441	sentence	denotes	The possible significance of the interactions between these proteins and PAX6 is discussed below.
T2742	8344-8347	DT	denotes	The
T2743	8357-8369	NN	denotes	significance
T2744	8348-8356	JJ	denotes	possible
T2745	8425-8434	VBN	denotes	discussed
T2746	8370-8372	IN	denotes	of
T2747	8373-8376	DT	denotes	the
T2748	8377-8389	NNS	denotes	interactions
T2749	8390-8397	IN	denotes	between
T2750	8398-8403	DT	denotes	these
T2751	8404-8412	NN	denotes	proteins
T2752	8413-8416	CC	denotes	and
T2753	8417-8421	NN	denotes	PAX6
T2754	8422-8424	VBZ	denotes	is
T2755	8435-8440	RB	denotes	below
T2756	8440-8441	.	denotes	.
T2839	8443-8460	JJ	denotes	Semi-quantitative
T2840	8461-8464	NN	denotes	PCR
T2841	8464-8649	sentence	denotes	To check that the Homer3, Dncl1 and Trim11 clones were not identified multiple times solely because they are highly abundant in the library, we performed a semi-quantitative PCR assay.
T2842	8465-8467	TO	denotes	To
T2843	8468-8473	VB	denotes	check
T2844	8609-8618	VBD	denotes	performed
T2845	8474-8478	IN	denotes	that
T2846	8524-8534	VBN	denotes	identified
T2847	8479-8482	DT	denotes	the
T2848	8508-8514	NNS	denotes	clones
T2849	8483-8489	NN	denotes	Homer3
T2850	8489-8491	,	denotes	,
T2851	8491-8496	NN	denotes	Dncl1
T2852	8497-8500	CC	denotes	and
T2853	8501-8507	NN	denotes	Trim11
T2854	8515-8519	VBD	denotes	were
T2855	8520-8523	RB	denotes	not
T2856	8535-8543	JJ	denotes	multiple
T2857	8544-8549	NNS	denotes	times
T2858	8550-8556	RB	denotes	solely
T2859	8570-8573	VBP	denotes	are
T2860	8557-8564	IN	denotes	because
T2861	8565-8569	PRP	denotes	they
T2862	8574-8580	RB	denotes	highly
T2863	8581-8589	JJ	denotes	abundant
T2864	8590-8592	IN	denotes	in
T2865	8593-8596	DT	denotes	the
T2866	8597-8604	NN	denotes	library
T2867	8604-8606	,	denotes	,
T2868	8606-8608	PRP	denotes	we
T2869	8619-8620	DT	denotes	a
T2870	8643-8648	NN	denotes	assay
T2871	8621-8638	JJ	denotes	semi-quantitative
T2872	8639-8642	NN	denotes	PCR
T2873	8648-8649	.	denotes	.
T2874	8649-8741	sentence	denotes	We compared the relative abundance of Homer3, Dncl1, Trim11 and Pax6 with Gapdh and Atp5a1.
T2875	8650-8652	PRP	denotes	We
T2876	8653-8661	VBD	denotes	compared
T2877	8662-8665	DT	denotes	the
T2878	8675-8684	NN	denotes	abundance
T2879	8666-8674	JJ	denotes	relative
T2880	8685-8687	IN	denotes	of
T2881	8688-8694	NN	denotes	Homer3
T2882	8694-8696	,	denotes	,
T2883	8696-8701	NN	denotes	Dncl1
T2884	8701-8703	,	denotes	,
T2885	8703-8709	NN	denotes	Trim11
T2886	8710-8713	CC	denotes	and
T2887	8714-8718	NN	denotes	Pax6
T2888	8719-8723	IN	denotes	with
T2889	8724-8729	NN	denotes	Gapdh
T2890	8730-8733	CC	denotes	and
T2891	8734-8740	NN	denotes	Atp5a1
T2892	8740-8741	.	denotes	.
T2893	8741-8852	sentence	denotes	Gapdh and Atp5a1 both show strong constitutive expression in a variety of tissues including the brain [29,30].
T2894	8742-8747	NN	denotes	Gapdh
T2895	8764-8768	VBP	denotes	show
T2896	8748-8751	CC	denotes	and
T2897	8752-8758	NN	denotes	Atp5a1
T2898	8759-8763	DT	denotes	both
T2899	8769-8775	JJ	denotes	strong
T2900	8789-8799	NN	denotes	expression
T2901	8776-8788	JJ	denotes	constitutive
T2902	8800-8802	IN	denotes	in
T2903	8803-8804	DT	denotes	a
T2904	8805-8812	NN	denotes	variety
T2905	8813-8815	IN	denotes	of
T2906	8816-8823	NNS	denotes	tissues
T2907	8824-8833	VBG	denotes	including
T2908	8834-8837	DT	denotes	the
T2909	8838-8843	NN	denotes	brain
T2910	8844-8845	-LRB-	denotes	[
T2911	8848-8850	CD	denotes	30
T2912	8845-8847	CD	denotes	29
T2913	8847-8848	,	denotes	,
T2914	8850-8851	-RRB-	denotes	]
T2915	8851-8852	.	denotes	.
T2916	8852-9112	sentence	denotes	Homer3, Dncl1, Trim11 and Pax6 were only amplified strongly after 35 cycles of PCR (Figure 2) and were therefore present at relatively low levels compared to Gapdh (amplified strongly after 25 cycles) and Atp5a1 (amplified strongly after 30 cycles; Figure 2).
T2917	8853-8859	NN	denotes	Homer3
T2918	8894-8903	VBN	denotes	amplified
T2919	8859-8861	,	denotes	,
T2920	8861-8866	NN	denotes	Dncl1
T2921	8866-8868	,	denotes	,
T2922	8868-8874	NN	denotes	Trim11
T2923	8875-8878	CC	denotes	and
T2924	8879-8883	NN	denotes	Pax6
T2925	8884-8888	VBD	denotes	were
T2926	8889-8893	RB	denotes	only
T2927	8904-8912	RB	denotes	strongly
T2928	8913-8918	IN	denotes	after
T2929	8919-8921	CD	denotes	35
T2930	8922-8928	NNS	denotes	cycles
T2931	8929-8931	IN	denotes	of
T2932	8932-8935	NN	denotes	PCR
T2933	8936-8937	-LRB-	denotes	(
T2934	8937-8943	NN	denotes	Figure
T2935	8944-8945	CD	denotes	2
T2936	8945-8946	-RRB-	denotes	)
T2937	8947-8950	CC	denotes	and
T2938	8951-8955	VBD	denotes	were
T2939	8956-8965	RB	denotes	therefore
T2940	8966-8973	JJ	denotes	present
T2941	8974-8976	IN	denotes	at
T2942	8977-8987	RB	denotes	relatively
T2943	8988-8991	JJ	denotes	low
T2944	8992-8998	NNS	denotes	levels
T2945	8999-9007	VBN	denotes	compared
T3000	9752-9755	DT	denotes	the
T3001	9764-9772	NN	denotes	proteins
T3002	9756-9763	VBN	denotes	encoded
T3003	9782-9794	RB	denotes	specifically
T3004	9795-9799	IN	denotes	with
T3005	9800-9803	DT	denotes	the
T3006	9815-9822	NN	denotes	peptide
T3007	9804-9805	NN	denotes	C
T3008	9806-9814	JJ	denotes	terminal
T3009	9805-9806	HYPH	denotes	-
T3010	9823-9825	CC	denotes	or
T3011	9826-9829	NN	denotes	PST
T3012	9830-9836	NN	denotes	domain
T3013	9837-9839	IN	denotes	of
T3014	9840-9844	NN	denotes	PAX6
T3015	9844-9845	.	denotes	.
T3382	9847-9852	NN	denotes	Yeast
T3383	9873-9885	NNS	denotes	interactions
T3384	9853-9856	CD	denotes	two
T3385	9857-9863	NN	denotes	hybrid
T3386	9856-9857	HYPH	denotes	-
T3387	9864-9872	JJ	denotes	pairwise
T3388	9885-10081	sentence	denotes	By library screening we identified two proteins (HOMER3 and DNCL1) that interact with the C-terminal peptide and three proteins (HOMER3, DNCL1 and TRIM11) that interact with the whole PST domain.
T3389	9886-9888	IN	denotes	By
T3390	9910-9920	VBD	denotes	identified
T3391	9889-9896	NN	denotes	library
T3392	9897-9906	NN	denotes	screening
T3393	9907-9909	PRP	denotes	we
T3394	9921-9924	CD	denotes	two
T3395	9925-9933	NN	denotes	proteins
T3396	9934-9935	-LRB-	denotes	(
T3397	9935-9941	NN	denotes	HOMER3
T3398	9942-9945	CC	denotes	and
T3399	9946-9951	NN	denotes	DNCL1
T3400	9951-9952	-RRB-	denotes	)
T3401	9953-9957	WDT	denotes	that
T3402	9958-9966	VBP	denotes	interact
T3403	9967-9971	IN	denotes	with
T3404	9972-9975	DT	denotes	the
T3405	9987-9994	NN	denotes	peptide
T3406	9976-9977	NN	denotes	C
T3407	9978-9986	JJ	denotes	terminal
T3408	9977-9978	HYPH	denotes	-
T3409	9995-9998	CC	denotes	and
T3410	9999-10004	CD	denotes	three
T3411	10005-10013	NN	denotes	proteins
T3412	10014-10015	-LRB-	denotes	(
T3413	10015-10021	NN	denotes	HOMER3
T3414	10021-10023	,	denotes	,
T3415	10023-10028	NN	denotes	DNCL1
T3416	10029-10032	CC	denotes	and
T3417	10033-10039	NN	denotes	TRIM11
T3418	10039-10040	-RRB-	denotes	)
T3419	10041-10045	WDT	denotes	that
T3420	10046-10054	VBP	denotes	interact
T3421	10055-10059	IN	denotes	with
T3422	10060-10063	DT	denotes	the
T3423	10074-10080	NN	denotes	domain
T3424	10064-10069	JJ	denotes	whole
T3425	10070-10073	NN	denotes	PST
T3426	10080-10081	.	denotes	.
T3427	10081-10237	sentence	denotes	This suggests that HOMER3 and DNCL1 interact specifically with the C-terminal peptide while TRIM11 interacts with a more N-terminal part of the PST domain.
T3428	10082-10086	DT	denotes	This
T3429	10087-10095	VBZ	denotes	suggests
T3430	10096-10100	IN	denotes	that
T3431	10118-10126	VBP	denotes	interact
T3432	10101-10107	NN	denotes	HOMER3
T3433	10108-10111	CC	denotes	and
T3434	10112-10117	NN	denotes	DNCL1
T3435	10127-10139	RB	denotes	specifically
T3436	10140-10144	IN	denotes	with
T3437	10145-10148	DT	denotes	the
T3438	10160-10167	NN	denotes	peptide
T3439	10149-10150	NN	denotes	C
T3440	10151-10159	JJ	denotes	terminal
T3441	10150-10151	HYPH	denotes	-
T3442	10168-10173	IN	denotes	while
T3443	10181-10190	VBZ	denotes	interacts
T3444	10174-10180	NN	denotes	TRIM11
T3445	10191-10195	IN	denotes	with
T3446	10196-10197	DT	denotes	a
T3447	10214-10218	NN	denotes	part
T3448	10198-10202	RBR	denotes	more
T3449	10205-10213	JJ	denotes	terminal
T3450	10203-10204	NN	denotes	N
T3451	10204-10205	HYPH	denotes	-
T3452	10219-10221	IN	denotes	of
T3453	10222-10225	DT	denotes	the
T3454	10230-10236	NN	denotes	domain
T3455	10226-10229	NN	denotes	PST
T3456	10236-10237	.	denotes	.
T3457	10237-10440	sentence	denotes	We conducted pairwise tests between specific constructs to confirm the interactions identified in the library screen and to further investigate the interaction between PAX6 and HOMER3, DNCL1 and TRIM11.
T3458	10238-10240	PRP	denotes	We
T3459	10241-10250	VBD	denotes	conducted
T3460	10251-10259	JJ	denotes	pairwise
T3461	10260-10265	NNS	denotes	tests
T3462	10266-10273	IN	denotes	between
T3463	10274-10282	JJ	denotes	specific
T3464	10283-10293	NNS	denotes	constructs
T3465	10294-10296	TO	denotes	to
T3466	10297-10304	VB	denotes	confirm
T3467	10305-10308	DT	denotes	the
T3468	10309-10321	NNS	denotes	interactions
T3469	10322-10332	VBN	denotes	identified
T3470	10333-10335	IN	denotes	in
T3471	10336-10339	DT	denotes	the
T3472	10348-10354	NN	denotes	screen
T3473	10340-10347	NN	denotes	library
T3474	10355-10358	CC	denotes	and
T3475	10359-10361	TO	denotes	to
T3476	10370-10381	VB	denotes	investigate
T3477	10362-10369	RB	denotes	further
T3478	10382-10385	DT	denotes	the
T3479	10386-10397	NN	denotes	interaction
T3480	10398-10405	IN	denotes	between
T3481	10406-10410	NN	denotes	PAX6
T3482	10411-10414	CC	denotes	and
T3483	10415-10421	NN	denotes	HOMER3
T3484	10421-10423	,	denotes	,
T3485	10423-10428	NN	denotes	DNCL1
T3486	10429-10432	CC	denotes	and
T3487	10433-10439	NN	denotes	TRIM11
T3488	10439-10440	.	denotes	.
T3489	10440-10581	sentence	denotes	The Dncl1 and Trim11 clones that were pulled out of the library were full-length, but the Homer3 cDNAs lacked the N-terminal 70 amino acids.
T3490	10441-10444	DT	denotes	The
T3491	10462-10468	NNS	denotes	clones
T3492	10445-10450	NN	denotes	Dncl1
T3493	10451-10454	CC	denotes	and
T3494	10455-10461	NN	denotes	Trim11
T3495	10505-10509	VBD	denotes	were
T3496	10469-10473	WDT	denotes	that
T3497	10479-10485	VBN	denotes	pulled
T3498	10474-10478	VBD	denotes	were
T3499	10486-10489	IN	denotes	out
T3500	10490-10492	IN	denotes	of
T3501	10493-10496	DT	denotes	the
T3502	10497-10504	NN	denotes	library
T3503	10510-10514	JJ	denotes	full
T3504	10515-10521	NN	denotes	length
T3505	10514-10515	HYPH	denotes	-
T3506	10521-10523	,	denotes	,
T3507	10523-10526	CC	denotes	but
T3508	10527-10530	DT	denotes	the
T3509	10538-10543	NNS	denotes	cDNAs
T3510	10531-10537	NN	denotes	Homer3
T3511	10544-10550	VBD	denotes	lacked
T3512	10551-10554	DT	denotes	the
T3513	10575-10580	NNS	denotes	acids
T3514	10555-10556	NN	denotes	N
T3515	10557-10565	JJ	denotes	terminal
T3516	10556-10557	HYPH	denotes	-
T3517	10566-10568	CD	denotes	70
T3518	10569-10574	NN	denotes	amino
T3519	10580-10581	.	denotes	.
T3520	10581-10709	sentence	denotes	The missing coding region was inserted into the truncated Homer3 cDNA to give a full-length expression construct (see Methods).
T3521	10582-10585	DT	denotes	The
T3522	10601-10607	NN	denotes	region
T3523	10586-10593	JJ	denotes	missing
T3524	10594-10600	NN	denotes	coding
T3525	10612-10620	VBN	denotes	inserted
T3526	10608-10611	VBD	denotes	was
T3527	10621-10625	IN	denotes	into
T3528	10626-10629	DT	denotes	the
T3529	10647-10651	NN	denotes	cDNA
T3530	10630-10639	VBN	denotes	truncated
T3531	10640-10646	NN	denotes	Homer3
T3532	10652-10654	TO	denotes	to
T3533	10655-10659	VB	denotes	give
T3534	10660-10661	DT	denotes	a
T3535	10685-10694	NN	denotes	construct
T3536	10662-10666	JJ	denotes	full
T3537	10667-10673	NN	denotes	length
T3538	10666-10667	HYPH	denotes	-
T3539	10674-10684	NN	denotes	expression
T3540	10695-10696	-LRB-	denotes	(
T3541	10696-10699	VB	denotes	see
T3542	10700-10707	NNS	denotes	Methods
T3543	10707-10708	-RRB-	denotes	)
T3544	10708-10709	.	denotes	.
T3545	10709-10803	sentence	denotes	Pairwise interactions were carried out with both the full-length and truncated Homer3 clones.
T3546	10710-10718	JJ	denotes	Pairwise
T3547	10719-10731	NNS	denotes	interactions
T3548	10737-10744	VBN	denotes	carried
T3549	10732-10736	VBD	denotes	were
T3550	10745-10748	RP	denotes	out
T3551	10749-10753	IN	denotes	with
T3552	10754-10758	CC	denotes	both
T3553	10796-10802	NNS	denotes	clones
T3554	10759-10762	DT	denotes	the
T3555	10763-10767	JJ	denotes	full
T3556	10768-10774	NN	denotes	length
T3557	10767-10768	HYPH	denotes	-
T3558	10775-10778	CC	denotes	and
T3559	10779-10788	VBN	denotes	truncated
T3560	10789-10795	NN	denotes	Homer3
T3561	10802-10803	.	denotes	.
T3562	10803-11018	sentence	denotes	We confirmed that the whole PAX6 PST domain interacts with HOMER3 (full-length and truncated constructs), TRIM11 and DNCL1, as all three reporter genes were strongly activated in pairwise tests (Figure 3; Table 1).
T3563	10804-10806	PRP	denotes	We
T3564	10807-10816	VBD	denotes	confirmed
T3565	10817-10821	IN	denotes	that
T3566	10848-10857	VBZ	denotes	interacts
T3567	10822-10825	DT	denotes	the
T3568	10841-10847	NN	denotes	domain
T3569	10826-10831	JJ	denotes	whole
T3570	10832-10836	NN	denotes	PAX6
T3571	10837-10840	NN	denotes	PST
T3572	10858-10862	IN	denotes	with
T3573	10863-10869	NN	denotes	HOMER3
T3574	10870-10871	-LRB-	denotes	(
T3575	10897-10907	NNS	denotes	constructs
T3576	10871-10875	JJ	denotes	full
T3577	10876-10882	NN	denotes	length
T3578	10875-10876	HYPH	denotes	-
T3579	10883-10886	CC	denotes	and
T3580	10887-10896	VBN	denotes	truncated
T3581	10907-10908	-RRB-	denotes	)
T3582	10908-10910	,	denotes	,
T3583	10910-10916	NN	denotes	TRIM11
T3584	10917-10920	CC	denotes	and
T3585	10921-10926	NN	denotes	DNCL1
T3586	10926-10928	,	denotes	,
T3587	10928-10930	IN	denotes	as
T3588	10970-10979	VBN	denotes	activated
T3589	10931-10934	DT	denotes	all
T3590	10950-10955	NNS	denotes	genes
T3591	10935-10940	CD	denotes	three
T3592	10941-10949	NN	denotes	reporter
T3593	10956-10960	VBD	denotes	were
T3594	10961-10969	RB	denotes	strongly
T3595	10980-10982	IN	denotes	in
T3596	10983-10991	JJ	denotes	pairwise
T3597	10992-10997	NNS	denotes	tests
T3598	10998-10999	-LRB-	denotes	(
T3599	11009-11014	NN	denotes	Table
T3600	10999-11005	NN	denotes	Figure
T3601	11006-11007	CD	denotes	3
T3602	11007-11008	:	denotes	;
T3603	11015-11016	CD	denotes	1
T3604	11016-11017	-RRB-	denotes	)
T3605	11017-11018	.	denotes	.
T3606	11018-11151	sentence	denotes	In contrast the interaction between the C-terminal peptide and HOMER3 or DNCL1 could not be confirmed with pairwise tests (Table 1).
T3607	11019-11021	IN	denotes	In
T3608	11111-11120	VBN	denotes	confirmed
T3609	11022-11030	NN	denotes	contrast
T3610	11031-11034	DT	denotes	the
T3611	11035-11046	NN	denotes	interaction
T3612	11047-11054	IN	denotes	between
T3613	11055-11058	DT	denotes	the
T3614	11070-11077	NN	denotes	peptide
T3615	11059-11060	NN	denotes	C
T3616	11061-11069	JJ	denotes	terminal
T3617	11060-11061	HYPH	denotes	-
T3618	11078-11081	CC	denotes	and
T3619	11082-11088	NN	denotes	HOMER3
T3620	11089-11091	CC	denotes	or
T3621	11092-11097	NN	denotes	DNCL1
T3622	11098-11103	MD	denotes	could
T3623	11104-11107	RB	denotes	not
T3624	11108-11110	VB	denotes	be
T3625	11121-11125	IN	denotes	with
T3626	11126-11134	JJ	denotes	pairwise
T3627	11135-11140	NNS	denotes	tests
T3628	11141-11142	-LRB-	denotes	(
T3629	11142-11147	NN	denotes	Table
T3630	11148-11149	CD	denotes	1
T3631	11149-11150	-RRB-	denotes	)
T3632	11150-11151	.	denotes	.
T3633	11151-11357	sentence	denotes	Occasionally, partial suppression of growth on plates containing 5-fluoro-orotic acid was observed, indicating low-level activation of the URA3 reporter; however HIS3 and LacZ activation were not observed.
T3634	11152-11164	RB	denotes	Occasionally
T3635	11242-11250	VBN	denotes	observed
T3636	11164-11166	,	denotes	,
T3637	11166-11173	JJ	denotes	partial
T3638	11174-11185	NN	denotes	suppression
T3639	11186-11188	IN	denotes	of
T3640	11189-11195	NN	denotes	growth
T3641	11196-11198	IN	denotes	on
T3642	11199-11205	NNS	denotes	plates
T3643	11206-11216	VBG	denotes	containing
T3644	11217-11218	CD	denotes	5
T3645	11226-11232	JJ	denotes	orotic
T3646	11218-11219	HYPH	denotes	-
T3647	11219-11225	JJ	denotes	fluoro
T3648	11225-11226	HYPH	denotes	-
T3649	11233-11237	NN	denotes	acid
T3650	11238-11241	VBD	denotes	was
T3651	11348-11356	VBN	denotes	observed
T3652	11250-11252	,	denotes	,
T3653	11252-11262	VBG	denotes	indicating
T3654	11263-11266	JJ	denotes	low
T3655	11267-11272	NN	denotes	level
T3656	11266-11267	HYPH	denotes	-
T3657	11273-11283	NN	denotes	activation
T3658	11284-11286	IN	denotes	of
T3659	11287-11290	DT	denotes	the
T3660	11296-11304	NN	denotes	reporter
T3661	11291-11295	NN	denotes	URA3
T3662	11304-11305	:	denotes	;
T3663	11306-11313	RB	denotes	however
T3664	11314-11318	NN	denotes	HIS3
T3665	11328-11338	NN	denotes	activation
T3666	11319-11322	CC	denotes	and
T3667	11323-11327	NN	denotes	LacZ
T3668	11339-11343	VBD	denotes	were
T3669	11344-11347	RB	denotes	not
T3670	11356-11357	.	denotes	.
T3671	11357-11500	sentence	denotes	The reasons for this are not clear, although it may be that the pairwise tests were of sub-optimal sensitivity compared to the library screen.
T3672	11358-11361	DT	denotes	The
T3673	11362-11369	NNS	denotes	reasons
T3674	11379-11382	VBP	denotes	are
T3675	11370-11373	IN	denotes	for
T3676	11374-11378	DT	denotes	this
T3677	11383-11386	RB	denotes	not
T3678	11387-11392	JJ	denotes	clear
T3679	11392-11394	,	denotes	,
T3680	11394-11402	IN	denotes	although
T3681	11410-11412	VB	denotes	be
T3682	11403-11405	PRP	denotes	it
T3683	11406-11409	MD	denotes	may
T3684	11413-11417	IN	denotes	that
T3685	11437-11441	VBD	denotes	were
T3686	11418-11421	DT	denotes	the
T3687	11431-11436	NNS	denotes	tests
T3688	11422-11430	JJ	denotes	pairwise
T3689	11442-11444	IN	denotes	of
T3690	11445-11456	JJ	denotes	sub-optimal
T3691	11457-11468	NN	denotes	sensitivity
T3692	11469-11477	VBN	denotes	compared
T3693	11478-11480	IN	denotes	to
T3694	11481-11484	DT	denotes	the
T3695	11493-11499	NN	denotes	screen
T3696	11485-11492	NN	denotes	library
T3697	11499-11500	.	denotes	.
T3698	11500-11750	sentence	denotes	However we were able to confirm that the C-terminal peptide is important for the interaction with HOMER3 and DNCL1 because interaction with the PAX6PST-CT construct, which lacks the final 32 amino acids, was completely abolished (Figure 3, Table 1).
T3699	11501-11508	RB	denotes	However
T3700	11512-11516	VBD	denotes	were
T3701	11509-11511	PRP	denotes	we
T3702	11517-11521	JJ	denotes	able
T3703	11522-11524	TO	denotes	to
T3704	11525-11532	VB	denotes	confirm
T3705	11533-11537	IN	denotes	that
T3706	11561-11563	VBZ	denotes	is
T3707	11538-11541	DT	denotes	the
T3708	11553-11560	NN	denotes	peptide
T3709	11542-11543	NN	denotes	C
T3710	11544-11552	JJ	denotes	terminal
T3711	11543-11544	HYPH	denotes	-
T3712	11564-11573	JJ	denotes	important
T3713	11574-11577	IN	denotes	for
T3714	11578-11581	DT	denotes	the
T3715	11582-11593	NN	denotes	interaction
T3716	11594-11598	IN	denotes	with
T3717	11599-11605	NN	denotes	HOMER3
T3718	11606-11609	CC	denotes	and
T3719	11610-11615	NN	denotes	DNCL1
T3720	11616-11623	IN	denotes	because
T3721	11720-11729	VBN	denotes	abolished
T3722	11624-11635	NN	denotes	interaction
T3723	11636-11640	IN	denotes	with
T3724	11641-11644	DT	denotes	the
T3725	11656-11665	NN	denotes	construct
T3726	11645-11652	NN	denotes	PAX6PST
T3727	11653-11655	NN	denotes	CT
T3728	11652-11653	HYPH	denotes	-
T3729	11665-11667	,	denotes	,
T3730	11667-11672	WDT	denotes	which
T3731	11673-11678	VBZ	denotes	lacks
T3732	11679-11682	DT	denotes	the
T3733	11698-11703	NNS	denotes	acids
T3734	11683-11688	JJ	denotes	final
T3735	11689-11691	CD	denotes	32
T3736	11692-11697	NN	denotes	amino
T3737	11703-11705	,	denotes	,
T3738	11705-11708	VBD	denotes	was
T3739	11709-11719	RB	denotes	completely
T3740	11730-11731	-LRB-	denotes	(
T3741	11741-11746	NN	denotes	Table
T3742	11731-11737	NN	denotes	Figure
T3743	11738-11739	CD	denotes	3
T3744	11739-11741	,	denotes	,
T3745	11747-11748	CD	denotes	1
T3746	11748-11749	-RRB-	denotes	)
T3747	11749-11750	.	denotes	.
T3748	11750-11830	sentence	denotes	TRIM11 interacted equally well with PAX6PST and PAX6PST-CT (Figure 3, Table 1).
T3749	11751-11757	NN	denotes	TRIM11
T3750	11758-11768	VBD	denotes	interacted
T3751	11769-11776	RB	denotes	equally
T3752	11777-11781	RB	denotes	well
T3753	11782-11786	IN	denotes	with
T3754	11787-11794	NN	denotes	PAX6PST
T3755	11795-11798	CC	denotes	and
T3756	11799-11806	NN	denotes	PAX6PST
T3757	11807-11809	NN	denotes	CT
T3758	11806-11807	HYPH	denotes	-
T3759	11810-11811	-LRB-	denotes	(
T3760	11821-11826	NN	denotes	Table
T3761	11811-11817	NN	denotes	Figure
T3762	11818-11819	CD	denotes	3
T3763	11819-11821	,	denotes	,
T3764	11827-11828	CD	denotes	1
T3765	11828-11829	-RRB-	denotes	)
T3766	11829-11830	.	denotes	.
T3767	11830-12071	sentence	denotes	This is consistent with the library screens in which TRIM11 was isolated with the PST domain but not with the C-terminal peptide and supports the idea that the C-terminal peptide is not important for the interaction between PAX6 and TRIM11.
T3768	11831-11835	DT	denotes	This
T3769	11836-11838	VBZ	denotes	is
T3770	11839-11849	JJ	denotes	consistent
T6929	24767-24770	NN	denotes	AGT
T8299	4684-4700	NN	denotes	Characterisation
T8300	4701-4703	IN	denotes	of
T8301	4704-4707	DT	denotes	the
T8302	4724-4731	NN	denotes	peptide
T8303	4708-4712	NN	denotes	PAX6
T8304	4713-4714	NN	denotes	C
T8305	4715-4723	JJ	denotes	terminal
T8306	4714-4715	HYPH	denotes	-
T8307	4731-4732	.	denotes	.
T8308	4732-4815	sentence	denotes	(a) CLUSTAL alignment of the terminal 42 amino acids of PAX6 from diverse species.
T8309	4733-4734	-LRB-	denotes	(
T8310	4734-4735	LS	denotes	a
T8311	4745-4754	NN	denotes	alignment
T8312	4735-4736	-RRB-	denotes	)
T8313	4737-4744	NNP	denotes	CLUSTAL
T8314	4755-4757	IN	denotes	of
T8315	4758-4761	DT	denotes	the
T8316	4780-4785	NNS	denotes	acids
T8317	4762-4770	JJ	denotes	terminal
T8318	4771-4773	CD	denotes	42
T8319	4774-4779	NN	denotes	amino
T8320	4786-4788	IN	denotes	of
T8321	4789-4793	NN	denotes	PAX6
T8322	4794-4798	IN	denotes	from
T8323	4799-4806	JJ	denotes	diverse
T8324	4807-4814	NNS	denotes	species
T8325	4814-4815	.	denotes	.
T8326	4815-4944	sentence	denotes	(*) indicates invariant residues, (:) indicates highly similar substitutions and (.) indicates moderately similar substitutions.
T8327	4816-4817	-LRB-	denotes	(
T8328	4820-4829	VBZ	denotes	indicates
T8329	4817-4818	SYM	denotes	*
T8330	4818-4819	-RRB-	denotes	)
T8331	4854-4863	VBZ	denotes	indicates
T8332	4830-4839	JJ	denotes	invariant
T8333	4840-4848	NNS	denotes	residues
T8334	4848-4850	,	denotes	,
T8335	4850-4851	-LRB-	denotes	(
T8336	4851-4852	SYM	denotes	:
T8337	4852-4853	-RRB-	denotes	)
T8338	4864-4870	RB	denotes	highly
T8339	4871-4878	JJ	denotes	similar
T8340	4879-4892	NNS	denotes	substitutions
T8341	4893-4896	CC	denotes	and
T8342	4897-4898	-LRB-	denotes	(
T8343	4901-4910	VBZ	denotes	indicates
T8344	4898-4899	SYM	denotes	.
T8345	4899-4900	-RRB-	denotes	)
T8346	4911-4921	RB	denotes	moderately
T8347	4922-4929	JJ	denotes	similar
T8348	4930-4943	NNS	denotes	substitutions
T8349	4943-4944	.	denotes	.
T8350	4944-5084	sentence	denotes	(b) Secondary structure analysis of the highly conserved terminal 28 amino acids predicts a single beta sheet (arrow) in the SVPVQ peptide.
T8351	4945-4946	-LRB-	denotes	(
T8352	4946-4947	LS	denotes	b
T8353	5026-5034	VBZ	denotes	predicts
T8354	4947-4948	-RRB-	denotes	)
T8355	4949-4958	JJ	denotes	Secondary
T8356	4969-4977	NN	denotes	analysis
T8357	4959-4968	NN	denotes	structure
T8358	4978-4980	IN	denotes	of
T8359	4981-4984	DT	denotes	the
T8360	5020-5025	NNS	denotes	acids
T8361	4985-4991	RB	denotes	highly
T8362	4992-5001	JJ	denotes	conserved
T8363	5002-5010	JJ	denotes	terminal
T8364	5011-5013	CD	denotes	28
T8365	5014-5019	NN	denotes	amino
T8366	5035-5036	DT	denotes	a
T8367	5049-5054	NN	denotes	sheet
T8368	5037-5043	JJ	denotes	single
T8369	5044-5048	NN	denotes	beta
T8370	5055-5056	-LRB-	denotes	(
T8371	5056-5061	NN	denotes	arrow
T8372	5061-5062	-RRB-	denotes	)
T8373	5063-5065	IN	denotes	in
T8374	5066-5069	DT	denotes	the
T8375	5076-5083	NN	denotes	peptide
T8376	5070-5075	NN	denotes	SVPVQ
T8377	5083-5084	.	denotes	.
T8378	5084-5176	sentence	denotes	(c) When 4 residues are added in the N-terminal direction, 2 beta sheets are now predicted.
T8379	5085-5086	-LRB-	denotes	(
T8380	5086-5087	LS	denotes	c
T8381	5166-5175	VBN	denotes	predicted
T8382	5087-5088	-RRB-	denotes	)
T8383	5089-5093	WRB	denotes	When
T8384	5109-5114	VBN	denotes	added
T8385	5094-5095	CD	denotes	4
T8386	5096-5104	NNS	denotes	residues
T8387	5105-5108	VBP	denotes	are
T8388	5115-5117	IN	denotes	in
T8389	5118-5121	DT	denotes	the
T8390	5133-5142	NN	denotes	direction
T8391	5122-5123	NN	denotes	N
T8392	5124-5132	JJ	denotes	terminal
T8393	5123-5124	HYPH	denotes	-
T8394	5142-5144	,	denotes	,
T8395	5144-5145	CD	denotes	2
T8396	5151-5157	NNS	denotes	sheets
T8397	5146-5150	NN	denotes	beta
T8398	5158-5161	VBP	denotes	are
T8399	5162-5165	RB	denotes	now
T8400	5175-5176	.	denotes	.
T8468	9123-9140	JJ	denotes	Semi-quantitative
T8469	9145-9153	NN	denotes	analysis
T8470	9141-9144	NN	denotes	PCR
T8471	9154-9156	IN	denotes	of
T8472	9157-9163	NN	denotes	Homer3
T8473	9163-9165	,	denotes	,
T8474	9165-9170	NN	denotes	Dncl1
T8475	9170-9172	,	denotes	,
T8476	9172-9178	NN	denotes	Trim11
T8477	9179-9182	CC	denotes	and
T8478	9183-9187	NN	denotes	Pax6
T8479	9188-9190	IN	denotes	in
T8480	9191-9194	DT	denotes	the
T8481	9212-9219	NN	denotes	library
T8482	9195-9200	NN	denotes	mouse
T8483	9201-9206	NN	denotes	brain
T8484	9207-9211	NN	denotes	cDNA
T8485	9219-9220	.	denotes	.
T8486	9220-9374	sentence	denotes	Library cDNA was amplified with primers specific for Pax6 (600 bp), Homer3 (485 bp band), Dncl1 (485 bp) and Trim11 (609 bp) for 20, 25, 30 or 35 cycles.
T8487	9221-9228	NN	denotes	Library
T8488	9229-9233	NN	denotes	cDNA
T8489	9238-9247	VBN	denotes	amplified
T8490	9234-9237	VBD	denotes	was
T8491	9248-9252	IN	denotes	with
T8492	9253-9260	NNS	denotes	primers
T8493	9261-9269	JJ	denotes	specific
T8494	9270-9273	IN	denotes	for
T8495	9274-9278	NN	denotes	Pax6
T8496	9279-9280	-LRB-	denotes	(
T8497	9284-9286	NN	denotes	bp
T8498	9280-9283	CD	denotes	600
T8499	9286-9287	-RRB-	denotes	)
T8500	9287-9289	,	denotes	,
T8501	9289-9295	NN	denotes	Homer3
T8502	9296-9297	-LRB-	denotes	(
T8503	9304-9308	NN	denotes	band
T8504	9297-9300	CD	denotes	485
T8505	9301-9303	NN	denotes	bp
T8506	9308-9309	-RRB-	denotes	)
T8507	9309-9311	,	denotes	,
T8508	9311-9316	NN	denotes	Dncl1
T8509	9317-9318	-LRB-	denotes	(
T8510	9322-9324	NN	denotes	bp
T8511	9318-9321	CD	denotes	485
T8512	9324-9325	-RRB-	denotes	)
T8513	9326-9329	CC	denotes	and
T8514	9330-9336	NN	denotes	Trim11
T8515	9337-9338	-LRB-	denotes	(
T8516	9342-9344	NN	denotes	bp
T8517	9338-9341	CD	denotes	609
T8518	9344-9345	-RRB-	denotes	)
T8519	9346-9349	IN	denotes	for
T8520	9350-9352	CD	denotes	20
T8521	9367-9373	NNS	denotes	cycles
T8522	9352-9354	,	denotes	,
T8523	9354-9356	CD	denotes	25
T8524	9356-9358	,	denotes	,
T8525	9358-9360	CD	denotes	30
T8526	9361-9363	CC	denotes	or
T8527	9364-9366	CD	denotes	35
T8528	9373-9374	.	denotes	.
T8529	9374-9480	sentence	denotes	Atp5a1 (415 bp) and Gapdh (450 bp), which are highly expressed in the brain, are included for comparison.
T8530	9375-9381	NN	denotes	Atp5a1
T8531	9456-9464	VBN	denotes	included
T8532	9382-9383	-LRB-	denotes	(
T8533	9387-9389	NN	denotes	bp
T8534	9383-9386	CD	denotes	415
T8535	9389-9390	-RRB-	denotes	)
T8536	9391-9394	CC	denotes	and
T8537	9395-9400	NN	denotes	Gapdh
T8538	9401-9402	-LRB-	denotes	(
T8539	9406-9408	NN	denotes	bp
T8540	9402-9405	CD	denotes	450
T8541	9408-9409	-RRB-	denotes	)
T8542	9409-9411	,	denotes	,
T8543	9411-9416	WDT	denotes	which
T8544	9428-9437	VBN	denotes	expressed
T8545	9417-9420	VBP	denotes	are
T8546	9421-9427	RB	denotes	highly
T8547	9438-9440	IN	denotes	in
T8548	9441-9444	DT	denotes	the
T8549	9445-9450	NN	denotes	brain
T8550	9450-9452	,	denotes	,
T8551	9452-9455	VBP	denotes	are
T8552	9465-9468	IN	denotes	for
T8553	9469-9479	NN	denotes	comparison
T8554	9479-9480	.	denotes	.
T8555	9480-9593	sentence	denotes	M indicates the Φ×174 HaeIII DNA size marker; the positions of the 603 bp and 310 bp marker bands are indicated.
T8556	9481-9482	NN	denotes	M
T8557	9483-9492	VBZ	denotes	indicates
T8558	9583-9592	VBN	denotes	indicated
T8559	9493-9496	DT	denotes	the
T8560	9519-9525	NN	denotes	marker
T8561	9497-9499	NN	denotes	Φ×
T8562	9503-9509	NN	denotes	HaeIII
T8563	9499-9502	CD	denotes	174
T8564	9510-9513	NN	denotes	DNA
T8565	9514-9518	NN	denotes	size
T8566	9525-9526	:	denotes	;
T8567	9527-9530	DT	denotes	the
T8568	9531-9540	NNS	denotes	positions
T8569	9541-9543	IN	denotes	of
T8570	9544-9547	DT	denotes	the
T8571	9573-9578	NNS	denotes	bands
T8572	9548-9551	CD	denotes	603
T8573	9552-9554	NN	denotes	bp
T8574	9555-9558	CC	denotes	and
T8575	9559-9562	CD	denotes	310
T8576	9563-9565	NN	denotes	bp
T8577	9566-9572	NN	denotes	marker
T8578	9579-9582	VBP	denotes	are
T8579	9592-9593	.	denotes	.
T8632	12082-12086	NN	denotes	LacZ
T8633	12101-12111	NN	denotes	activation
T8634	12087-12095	NN	denotes	reporter
T8635	12096-12100	NN	denotes	gene
T8636	12112-12114	IN	denotes	in
T8637	12115-12123	JJ	denotes	pairwise
T8638	12124-12129	NNS	denotes	tests
T8639	12129-12130	.	denotes	.
T8640	12130-12231	sentence	denotes	pPC86 constructs are shown across the top, and pDBLeu constructs are shown down the right hand side.
T8641	12131-12136	NN	denotes	pPC86
T8642	12137-12147	NNS	denotes	constructs
T8643	12152-12157	VBN	denotes	shown
T8644	12148-12151	VBP	denotes	are
T8645	12158-12164	IN	denotes	across
T8646	12165-12168	DT	denotes	the
T8647	12169-12172	NN	denotes	top
T8648	12172-12174	,	denotes	,
T8649	12174-12177	CC	denotes	and
T8650	12178-12184	NN	denotes	pDBLeu
T8651	12185-12195	NNS	denotes	constructs
T8652	12200-12205	VBN	denotes	shown
T8653	12196-12199	VBP	denotes	are
T8654	12206-12210	IN	denotes	down
T8655	12211-12214	DT	denotes	the
T8656	12226-12230	NN	denotes	side
T8657	12215-12220	JJ	denotes	right
T8658	12221-12225	NN	denotes	hand
T8659	12230-12231	.	denotes	.
T8660	12231-12492	sentence	denotes	PAX6PST, PAX6 PST domain; PAX6PST/Q422R, PAX6 PST domain with the Q422R mutation; PAX6PST/X423L, PAX6 PST domain with the X423L mutation, PAX6PST/1615del10, PAX6 PST domain with the 1615 del10 mutation; PAX6PST-CT, PAX6 PST domain minus the C-terminal peptide.
T8661	12232-12239	NN	denotes	PAX6PST
T8662	12239-12241	,	denotes	,
T8663	12241-12245	NN	denotes	PAX6
T8664	12250-12256	NN	denotes	domain
T8665	12246-12249	NN	denotes	PST
T8666	12256-12257	:	denotes	;
T8667	12258-12265	NN	denotes	PAX6PST
T8668	12266-12271	NN	denotes	Q422R
T8669	12265-12266	HYPH	denotes	/
T8670	12271-12273	,	denotes	,
T8671	12273-12277	NN	denotes	PAX6
T8672	12282-12288	NN	denotes	domain
T8673	12278-12281	NN	denotes	PST
T8674	12289-12293	IN	denotes	with
T8675	12294-12297	DT	denotes	the
T8676	12304-12312	NN	denotes	mutation
T8677	12298-12303	NN	denotes	Q422R
T8678	12312-12313	:	denotes	;
T8679	12314-12321	NN	denotes	PAX6PST
T8680	12322-12327	NN	denotes	X423L
T8681	12321-12322	HYPH	denotes	/
T8682	12327-12329	,	denotes	,
T8683	12329-12333	NN	denotes	PAX6
T8684	12338-12344	NN	denotes	domain
T8685	12334-12337	NN	denotes	PST
T8686	12345-12349	IN	denotes	with
T8687	12350-12353	DT	denotes	the
T8688	12360-12368	NN	denotes	mutation
T8689	12354-12359	NN	denotes	X423L
T8690	12368-12370	,	denotes	,
T8691	12370-12377	NN	denotes	PAX6PST
T8692	12378-12387	NN	denotes	1615del10
T8693	12377-12378	HYPH	denotes	/
T8694	12387-12389	,	denotes	,
T8695	12389-12393	NN	denotes	PAX6
T8696	12398-12404	NN	denotes	domain
T8697	12394-12397	NN	denotes	PST
T8698	12405-12409	IN	denotes	with
T8699	12410-12413	DT	denotes	the
T8700	12425-12433	NN	denotes	mutation
T8701	12414-12418	CD	denotes	1615
T8702	12419-12424	NN	denotes	del10
T8703	12433-12434	:	denotes	;
T8704	12435-12442	NN	denotes	PAX6PST
T8705	12443-12445	NN	denotes	CT
T8706	12442-12443	HYPH	denotes	-
T8707	12445-12447	,	denotes	,
T8708	12447-12451	NN	denotes	PAX6
T8709	12452-12455	NN	denotes	PST
T8710	12456-12462	NN	denotes	domain
T8711	12463-12468	CC	denotes	minus
T8712	12469-12472	DT	denotes	the
T8713	12484-12491	NN	denotes	peptide
T8714	12473-12474	NN	denotes	C
T8715	12475-12483	JJ	denotes	terminal
T8716	12474-12475	HYPH	denotes	-
T8717	12491-12492	.	denotes	.
T8718	12492-12560	sentence	denotes	'Truncated HOMER3' is HOMER3 lacking the N-terminal 70 amino acids.
T8719	12493-12494	``	denotes	'
T8720	12512-12514	VBZ	denotes	is
T8721	12494-12503	VBN	denotes	Truncated
T8722	12504-12510	NN	denotes	HOMER3
T8723	12510-12511	''	denotes	'
T8724	12515-12521	NN	denotes	HOMER3
T8725	12522-12529	VBG	denotes	lacking
T8726	12530-12533	DT	denotes	the
T8727	12554-12559	NNS	denotes	acids
T8728	12534-12535	NN	denotes	N
T8729	12536-12544	JJ	denotes	terminal
T8730	12535-12536	HYPH	denotes	-
T8731	12545-12547	CD	denotes	70
T8732	12548-12553	NN	denotes	amino
T8733	12559-12560	.	denotes	.
T8734	12560-12614	sentence	denotes	Five control strains are shown for comparison (left).
T8735	12561-12565	CD	denotes	Five
T8736	12574-12581	NNS	denotes	strains
T8737	12566-12573	NN	denotes	control
T8738	12586-12591	VBN	denotes	shown
T8739	12582-12585	VBP	denotes	are
T8740	12592-12595	IN	denotes	for
T8741	12596-12606	NN	denotes	comparison
T8742	12607-12608	-LRB-	denotes	(
T8743	12608-12612	JJ	denotes	left
T8744	12612-12613	-RRB-	denotes	)
T8745	12613-12614	.	denotes	.
T8746	12614-12676	sentence	denotes	These range from non-interactor (A) to strong interactor (E).
T8747	12615-12620	DT	denotes	These
T8748	12621-12626	VBP	denotes	range
T8749	12627-12631	IN	denotes	from
T8750	12632-12646	NN	denotes	non-interactor
T8751	12647-12648	-LRB-	denotes	(
T8752	12648-12649	NN	denotes	A
T8753	12649-12650	-RRB-	denotes	)
T8754	12651-12653	IN	denotes	to
T8755	12654-12660	JJ	denotes	strong
T8756	12661-12671	NN	denotes	interactor
T8757	12672-12673	-LRB-	denotes	(
T8758	12673-12674	NN	denotes	E
T8759	12674-12675	-RRB-	denotes	)
T8760	12675-12676	.	denotes	.
T8837	12686-12694	JJ	denotes	Pairwise
T8838	12707-12712	NNS	denotes	tests
T8839	12695-12706	NN	denotes	interaction
T8840	12713-12720	IN	denotes	between
T8841	12721-12727	JJ	denotes	normal
T8842	12744-12754	NNS	denotes	constructs
T8843	12728-12731	CC	denotes	and
T8844	12732-12738	JJ	denotes	mutant
T8845	12739-12743	NN	denotes	PAX6
T8846	12755-12758	CC	denotes	and
T8847	12759-12765	NN	denotes	HOMER3
T8848	12765-12767	,	denotes	,
T8849	12767-12772	NN	denotes	DNCL1
T8850	12773-12776	CC	denotes	and
T8851	12777-12783	NN	denotes	TRIM11
T8852	12783-12784	SYM	denotes	.
T8853	12784-12958	sentence	denotes	+++: strong interaction; ++: moderate interaction; +: weak interaction; (+) borderline interaction with one or two reporters activated at very low levels; 0: no interaction.
T8854	12785-12788	SYM	denotes	+++
T8855	12788-12790	:	denotes	:
T8856	12790-12796	JJ	denotes	strong
T8857	12797-12808	NN	denotes	interaction
T8858	12808-12809	,	denotes	;
T8859	12810-12812	SYM	denotes	++
T8860	12812-12814	:	denotes	:
T8861	12814-12822	JJ	denotes	moderate
T8862	12823-12834	NN	denotes	interaction
T8863	12834-12835	,	denotes	;
T8864	12836-12837	SYM	denotes	+
T8865	12837-12839	:	denotes	:
T8866	12839-12843	JJ	denotes	weak
T8867	12844-12855	NN	denotes	interaction
T8868	12855-12856	,	denotes	;
T8869	12857-12858	-LRB-	denotes	(
T8870	12859-12860	-RRB-	denotes	)
T8871	12858-12859	SYM	denotes	+
T8872	12861-12871	JJ	denotes	borderline
T8873	12872-12883	NN	denotes	interaction
T8874	12884-12888	IN	denotes	with
T8875	12889-12892	CD	denotes	one
T8876	12900-12909	NNS	denotes	reporters
T8877	12893-12895	CC	denotes	or
T8878	12896-12899	CD	denotes	two
T8879	12910-12919	VBN	denotes	activated
T8880	12920-12922	IN	denotes	at
T8881	12923-12927	RB	denotes	very
T8882	12928-12931	JJ	denotes	low
T8883	12932-12938	NNS	denotes	levels
T8884	12938-12939	,	denotes	;
T8885	12940-12941	CD	denotes	0
T8886	12941-12943	:	denotes	:
T8887	12943-12945	DT	denotes	no
T8888	12946-12957	NN	denotes	interaction
T8889	12957-12958	.	denotes	.
T8890	12958-13251	sentence	denotes	PAX6PST, PAX6 PST domain; PAX6CTP, PAX6 C-terminal peptide; PAX6PST-CT, PAX6 PST domain minus the C-terminal peptide; PAX6PST/Q422R, PAX6 PST domain with the Q422R mutation; PAX6PST/X423L, PAX6 PST domain with the X423L mutation, PAX6PST/1615del, PAX6 PST domain with the 1615 del10 mutation.
T8891	12959-12966	NN	denotes	PAX6PST
T8892	12966-12968	,	denotes	,
T8893	12968-12972	NN	denotes	PAX6
T8894	12977-12983	NN	denotes	domain
T8895	12973-12976	NN	denotes	PST
T8896	12983-12984	,	denotes	;
T8897	12985-12992	NN	denotes	PAX6CTP
T8898	12992-12994	,	denotes	,
T8899	12994-12998	NN	denotes	PAX6
T8900	13010-13017	NN	denotes	peptide
T8901	12999-13000	NN	denotes	C
T8902	13001-13009	JJ	denotes	terminal
T8903	13000-13001	HYPH	denotes	-
T8904	13017-13018	,	denotes	;
T8905	13019-13026	NN	denotes	PAX6PST
T8906	13027-13029	NN	denotes	CT
T8907	13026-13027	HYPH	denotes	-
T8908	13029-13031	,	denotes	,
T8909	13031-13035	NN	denotes	PAX6
T8910	13040-13046	NN	denotes	domain
T8911	13036-13039	NN	denotes	PST
T8912	13047-13052	CC	denotes	minus
T8913	13053-13056	DT	denotes	the
T8914	13068-13075	NN	denotes	peptide
T8915	13057-13058	NN	denotes	C
T8916	13059-13067	JJ	denotes	terminal
T8917	13058-13059	HYPH	denotes	-
T8918	13075-13076	,	denotes	;
T8919	13077-13084	NN	denotes	PAX6PST
T8920	13085-13090	NN	denotes	Q422R
T8921	13084-13085	HYPH	denotes	/
T8922	13090-13092	,	denotes	,
T8923	13092-13096	NN	denotes	PAX6
T8924	13101-13107	NN	denotes	domain
T8925	13097-13100	NN	denotes	PST
T8926	13108-13112	IN	denotes	with
T8927	13113-13116	DT	denotes	the
T8928	13123-13131	NN	denotes	mutation
T8929	13117-13122	NN	denotes	Q422R
T8930	13131-13132	,	denotes	;
T8931	13133-13140	NN	denotes	PAX6PST
T8932	13141-13146	NN	denotes	X423L
T8933	13140-13141	HYPH	denotes	/
T8934	13146-13148	,	denotes	,
T8935	13148-13152	NN	denotes	PAX6
T8936	13157-13163	NN	denotes	domain
T8937	13153-13156	NN	denotes	PST
T8938	13164-13168	IN	denotes	with
T8939	13169-13172	DT	denotes	the
T8940	13179-13187	NN	denotes	mutation
T8941	13173-13178	NN	denotes	X423L
T8942	13187-13189	,	denotes	,
T8943	13189-13196	NN	denotes	PAX6PST
T8944	13197-13204	NN	denotes	1615del
T8945	13196-13197	HYPH	denotes	/
T8946	13204-13206	,	denotes	,
T8947	13206-13210	NN	denotes	PAX6
T8948	13215-13221	NN	denotes	domain
T8949	13211-13214	NN	denotes	PST
T8950	13222-13226	IN	denotes	with
T8951	13227-13230	DT	denotes	the
T8952	13242-13250	NN	denotes	mutation
T8953	13231-13235	CD	denotes	1615
T8954	13236-13241	NN	denotes	del10
T8955	13250-13251	.	denotes	.
T8956	13251-13361	sentence	denotes	HOMER3-FL, HOMER3 full-length clone; HOMER3-Tr, truncated HOMER3 clone lacking the N-terminal 70 amino acids.
T8957	13252-13258	NN	denotes	HOMER3
T8958	13259-13261	NN	denotes	FL
T8959	13258-13259	HYPH	denotes	-
T8960	13261-13263	,	denotes	,
T8961	13263-13269	NN	denotes	HOMER3
T8962	13282-13287	NN	denotes	clone
T8963	13270-13274	JJ	denotes	full
T8964	13275-13281	NN	denotes	length
T8965	13274-13275	HYPH	denotes	-
T8966	13287-13288	,	denotes	;
T8967	13289-13295	NN	denotes	HOMER3
T8968	13296-13298	NN	denotes	Tr
T8969	13295-13296	HYPH	denotes	-
T8970	13298-13300	,	denotes	,
T8971	13300-13309	VBN	denotes	truncated
T8972	13317-13322	NN	denotes	clone
T8973	13310-13316	NN	denotes	HOMER3
T8974	13323-13330	VBG	denotes	lacking
T8975	13331-13334	DT	denotes	the
T8976	13355-13360	NNS	denotes	acids
T8977	13335-13336	NN	denotes	N
T8978	13337-13345	JJ	denotes	terminal
T8979	13336-13337	HYPH	denotes	-
T8980	13346-13348	CD	denotes	70
T8981	13349-13354	NN	denotes	amino
T8982	13360-13361	.	denotes	.
T3780	11904-11908	IN	denotes	with
T3781	11909-11912	DT	denotes	the
T3782	11917-11923	NN	denotes	domain
T3783	11913-11916	NN	denotes	PST
T3784	11924-11927	CC	denotes	but
T3785	11928-11931	RB	denotes	not
T3786	11932-11936	IN	denotes	with
T3787	11937-11940	DT	denotes	the
T3788	11952-11959	NN	denotes	peptide
T3789	11941-11942	NN	denotes	C
T3790	11943-11951	JJ	denotes	terminal
T3791	11942-11943	HYPH	denotes	-
T3792	11960-11963	CC	denotes	and
T3793	11964-11972	VBZ	denotes	supports
T3794	11973-11976	DT	denotes	the
T3795	11977-11981	NN	denotes	idea
T3796	11982-11986	IN	denotes	that
T3797	12010-12012	VBZ	denotes	is
T3798	11987-11990	DT	denotes	the
T3799	12002-12009	NN	denotes	peptide
T3800	11991-11992	NN	denotes	C
T3801	11993-12001	JJ	denotes	terminal
T3802	11992-11993	HYPH	denotes	-
T3803	12013-12016	RB	denotes	not
T3804	12017-12026	JJ	denotes	important
T3805	12027-12030	IN	denotes	for
T3806	12031-12034	DT	denotes	the
T3807	12035-12046	NN	denotes	interaction
T3808	12047-12054	IN	denotes	between
T3809	12055-12059	NN	denotes	PAX6
T3810	12060-12063	CC	denotes	and
T3811	12064-12070	NN	denotes	TRIM11
T2946	9008-9010	IN	denotes	to
T2947	9011-9016	NN	denotes	Gapdh
T2948	9017-9018	-LRB-	denotes	(
T2949	9018-9027	VBN	denotes	amplified
T2950	9028-9036	RB	denotes	strongly
T2951	9037-9042	IN	denotes	after
T2952	9043-9045	CD	denotes	25
T2953	9046-9052	NNS	denotes	cycles
T2954	9052-9053	-RRB-	denotes	)
T2955	9054-9057	CC	denotes	and
T2956	9058-9064	NN	denotes	Atp5a1
T2957	9065-9066	-LRB-	denotes	(
T2958	9066-9075	VBN	denotes	amplified
T2959	9076-9084	RB	denotes	strongly
T2960	9085-9090	IN	denotes	after
T2961	9091-9093	CD	denotes	30
T2962	9094-9100	NNS	denotes	cycles
T2963	9100-9101	:	denotes	;
T2964	9102-9108	NN	denotes	Figure
T2965	9109-9110	CD	denotes	2
T2966	9110-9111	-RRB-	denotes	)
T2967	9111-9112	.	denotes	.
T2968	9112-9684	sentence	denotes	Figure 2 Semi-quantitative PCR analysis of Homer3, Dncl1, Trim11 and Pax6 in the mouse brain cDNA library. Library cDNA was amplified with primers specific for Pax6 (600 bp), Homer3 (485 bp band), Dncl1 (485 bp) and Trim11 (609 bp) for 20, 25, 30 or 35 cycles. Atp5a1 (415 bp) and Gapdh (450 bp), which are highly expressed in the brain, are included for comparison. M indicates the Φ×174 HaeIII DNA size marker; the positions of the 603 bp and 310 bp marker bands are indicated. We concluded that Homer3, Dncl1 and Trim11 clones were not highly abundant in the library.
T2969	9594-9596	PRP	denotes	We
T2970	9597-9606	VBD	denotes	concluded
T2971	9607-9611	IN	denotes	that
T2972	9644-9648	VBD	denotes	were
T2973	9612-9618	NN	denotes	Homer3
T2974	9637-9643	NNS	denotes	clones
T2975	9618-9620	,	denotes	,
T2976	9620-9625	NN	denotes	Dncl1
T2977	9626-9629	CC	denotes	and
T2978	9630-9636	NN	denotes	Trim11
T2979	9649-9652	RB	denotes	not
T2980	9653-9659	RB	denotes	highly
T2981	9660-9668	JJ	denotes	abundant
T2982	9669-9671	IN	denotes	in
T2983	9672-9675	DT	denotes	the
T2984	9676-9683	NN	denotes	library
T2985	9683-9684	.	denotes	.
T2986	9684-9845	sentence	denotes	This is consistent with the idea that they were pulled out because the encoded proteins interact specifically with the C-terminal peptide or PST domain of PAX6.
T2987	9685-9689	DT	denotes	This
T2988	9690-9692	VBZ	denotes	is
T2989	9693-9703	JJ	denotes	consistent
T2990	9704-9708	IN	denotes	with
T2991	9709-9712	DT	denotes	the
T2992	9713-9717	NN	denotes	idea
T2993	9718-9722	IN	denotes	that
T2994	9733-9739	VBN	denotes	pulled
T2995	9723-9727	PRP	denotes	they
T2996	9728-9732	VBD	denotes	were
T2997	9740-9743	RP	denotes	out
T2998	9744-9751	IN	denotes	because
T2999	9773-9781	VBP	denotes	interact
T3812	12070-12071	.	denotes	.
T3813	12071-12072	sentence	denotes
T1864	4652-4659	NNP	denotes	lividus
T1865	4659-4660	-RRB-	denotes	)
T1866	4661-4662	-LRB-	denotes	(
T1867	4662-4668	NN	denotes	Figure
T1868	4669-4671	CD	denotes	1a
T1869	4671-4672	-RRB-	denotes	)
T1870	4672-4673	.	denotes	.
T1871	4673-5406	sentence	denotes	Figure 1 Characterisation of the PAX6 C-terminal peptide. (a) CLUSTAL alignment of the terminal 42 amino acids of PAX6 from diverse species. (*) indicates invariant residues, (:) indicates highly similar substitutions and (.) indicates moderately similar substitutions. (b) Secondary structure analysis of the highly conserved terminal 28 amino acids predicts a single beta sheet (arrow) in the SVPVQ peptide. (c) When 4 residues are added in the N-terminal direction, 2 beta sheets are now predicted. We subjected the whole PAX6 PST domain to secondary structure analysis using JPRED, a program that uses a number of different protein structure prediction algorithms to generate a consensus secondary structure (Figure 1) [25,26].
T1872	5177-5179	PRP	denotes	We
T1873	5180-5189	VBD	denotes	subjected
T1874	5190-5193	DT	denotes	the
T1875	5209-5215	NN	denotes	domain
T1876	5194-5199	JJ	denotes	whole
T1877	5200-5204	NN	denotes	PAX6
T1878	5205-5208	NN	denotes	PST
T1879	5216-5218	IN	denotes	to
T3823	13604-13605	JJ	denotes	n
T3822	13602-13604	NN	denotes	co
T3821	13600-13601	VBP	denotes	g
T3820	13600-13605	sentence	denotes	g con
T3819	13598-13600	NNS	denotes	in
T3771	11850-11854	IN	denotes	with
T3772	11855-11858	DT	denotes	the
T3773	11867-11874	NNS	denotes	screens
T3774	11859-11866	NN	denotes	library
T3775	11875-11877	IN	denotes	in
T3776	11895-11903	VBN	denotes	isolated
T3777	11878-11883	WDT	denotes	which
T3778	11884-11890	NN	denotes	TRIM11
T3779	11891-11894	VBD	denotes	was
T3818	13597-13598	CD	denotes	v
T3817	13597-13600	sentence	denotes	vin
T3816	13596-13597	VBG	denotes	a
T3815	13595-13596	NN	denotes	H
T3814	13595-13597	sentence	denotes	Ha
T3826	13606-13607	VBG	denotes	i
T3825	13605-13606	JJ	denotes	f
T3824	13605-13609	sentence	denotes	firm
T3834	13623-13625	,	denotes	,
T3833	13617-13623	NN	denotes	HOMER3
T3832	13642-13650	VBP	denotes	interact
T3831	13612-13616	IN	denotes	that
T3830	13685-13697	VBD	denotes	investigated
T3829	13609-13611	VBN	denotes	ed
T3828	13609-13838	sentence	denotes	ed that HOMER3, DNCL1 and TRIM11 interact with the PAX6 PST domain, we next investigated how the interactions were affected by three C-terminal PAX6 mutations that have been previously described in patients with ocular anomalies.
T3827	13607-13609	JJ	denotes	rm
T6413	23102-23107	NN	denotes	brain
T6412	23098-23101	DT	denotes	the
T6411	23095-23097	IN	denotes	in
T6410	23071-23080	RB	denotes	initially
T6409	23066-23070	VBD	denotes	were
T6424	23161-23169	VBN	denotes	impaired
T6423	23213-23217	VB	denotes	have
T6422	23156-23160	IN	denotes	that
T6421	23145-23155	VBG	denotes	suggesting
T6420	23143-23145	,	denotes	,
T6419	23137-23143	NN	denotes	retina
T6418	23133-23136	DT	denotes	the
T6417	23130-23132	IN	denotes	in
T6416	23117-23119	VB	denotes	be
T6415	23112-23116	RB	denotes	also
T6414	23108-23111	MD	denotes	may
T6408	23081-23094	VBN	denotes	characterized
T6407	23061-23065	WDT	denotes	that
T6406	23040-23049	NN	denotes	transport
T6405	23036-23039	CC	denotes	and
T6404	23050-23060	NNS	denotes	mechanisms
T6403	23025-23035	NN	denotes	signalling
T6402	23120-23129	VBN	denotes	conserved
T6401	23020-23024	IN	denotes	that
T6400	23011-23019	NN	denotes	evidence
T6399	23008-23010	VBZ	denotes	is
T6398	23002-23007	EX	denotes	There
T6397	23001-23307	sentence	denotes	There is evidence that signalling and transport mechanisms that were initially characterized in the brain may also be conserved in the retina, suggesting that impaired PAX6 protein-protein interactions may also have implications for the retinal defects observed in individuals with PAX6 mutations [53,54].
T6396	23000-23001	.	denotes	.
T6395	22981-22990	NN	denotes	extension
T6394	22971-22972	HYPH	denotes	-
T6393	22972-22980	JJ	denotes	terminal
T6392	22970-22971	NN	denotes	C
T6391	22962-22969	JJ	denotes	unusual
T6390	22991-23000	NNS	denotes	mutations
T6389	22956-22961	DT	denotes	these
T6388	22953-22955	IN	denotes	of
T6387	22937-22945	JJ	denotes	specific
T6386	22946-22952	NN	denotes	effect
T6385	22935-22936	DT	denotes	a
T6384	22930-22934	IN	denotes	from
R257	T834	T835	det	The,protein
R258	T835	T837	nsubj	protein,is
R259	T836	T835	compound	PAX6,protein
R260	T838	T839	det	a,member
R261	T839	T837	attr	member,is
R262	T840	T839	prep	of,member
R263	T841	T842	det	the,family
R264	T842	T840	pobj	family,of
R265	T843	T842	nmod	PAX,family
R266	T844	T843	punct	(,PAX
R267	T845	T846	amod	paired,box
R268	T846	T843	appos	box,PAX
R269	T847	T846	punct	-,box
R270	T848	T842	punct	),family
R271	T849	T842	prep	of,family
R272	T850	T851	amod	transcriptional,regulators
R273	T851	T849	pobj	regulators,of
R274	T852	T837	cc	and,is
R275	T853	T837	conj	is,is
R276	T854	T853	acomp	essential,is
R277	T855	T854	prep	for,essential
R278	T856	T857	amod	normal,development
R279	T857	T855	pobj	development,for
R280	T858	T857	amod	ocular,development
R281	T859	T858	cc	and,ocular
R282	T860	T858	conj	neural,ocular
R283	T861	T862	punct	[,1
R284	T862	T853	parataxis	1,is
R285	T863	T862	punct	],1
R286	T864	T837	punct	.,is
R287	T866	T867	amod	Heterozygous,mutations
R288	T867	T868	nsubj	mutations,cause
R289	T869	T867	prep	of,mutations
R290	T870	T871	det	the,gene
R291	T871	T869	pobj	gene,of
R292	T872	T871	amod	human,gene
R293	T873	T871	compound	PAX6,gene
R294	T874	T868	dobj	aniridia,cause
R295	T875	T874	punct	(,aniridia
R296	T876	T874	appos	absence,aniridia
R297	T877	T876	prep	of,absence
R298	T878	T879	det	the,iris
R299	T879	T877	pobj	iris,of
R300	T880	T874	punct	),aniridia
R301	T881	T874	cc	and,aniridia
R302	T882	T883	det	a,range
R303	T883	T874	conj	range,aniridia
R304	T884	T883	prep	of,range
R305	T885	T886	amod	other,malformations
R306	T886	T884	pobj	malformations,of
R307	T887	T886	amod	congenital,malformations
R308	T888	T886	compound	eye,malformations
R309	T889	T890	punct	[,2
R310	T890	T868	parataxis	2,cause
R311	T891	T890	punct	],2
R312	T892	T868	punct	.,cause
R313	T894	T895	amod	Neural,defects
R314	T895	T896	nsubj	defects,are
R315	T897	T898	amod	such,as
R316	T898	T895	prep	as,defects
R317	T899	T900	amod	foveal,hypoplasia
R318	T900	T898	pobj	hypoplasia,as
R319	T901	T900	cc	and,hypoplasia
R320	T902	T903	amod	optic,nerve
R321	T903	T904	compound	nerve,hypoplasia
R322	T904	T900	conj	hypoplasia,hypoplasia
R323	T905	T896	acomp	common,are
R324	T906	T896	prep	in,are
R325	T907	T908	npadvmod	PAX6,associated
R326	T908	T910	amod	associated,disease
R327	T909	T908	punct	-,associated
R328	T910	T906	pobj	disease,in
R329	T911	T910	compound	eye,disease
R330	T912	T913	punct	[,3
R331	T913	T896	parataxis	3,are
R332	T914	T915	punct	-,5
R333	T915	T913	prep	5,3
R334	T916	T913	punct	],3
R335	T917	T896	punct	.,are
R336	T919	T920	amod	Homozygous,mutations
R337	T920	T921	nsubj	mutations,are
R338	T922	T920	prep	in,mutations
R339	T923	T922	pobj	man,in
R340	T924	T923	cc	and,man
R341	T925	T923	conj	mouse,man
R342	T926	T921	acomp	lethal,are
R343	T927	T921	cc	and,are
R344	T928	T921	conj	result,are
R345	T929	T928	prep	in,result
R346	T930	T931	amod	severe,abnormalities
R347	T931	T929	pobj	abnormalities,in
R348	T932	T931	amod	developmental,abnormalities
R349	T933	T931	prep	including,abnormalities
R350	T934	T933	pobj	anophthalmia,including
R351	T935	T934	punct	", ",anophthalmia
R352	T936	T937	amod	severe,reduction
R353	T937	T934	conj	reduction,anophthalmia
R354	T938	T937	prep	of,reduction
R355	T939	T940	det	the,structures
R356	T940	T938	pobj	structures,of
R357	T941	T940	amod	olfactory,structures
R358	T942	T937	cc	and,reduction
R359	T943	T944	amod	gross,malformations
R360	T944	T937	conj	malformations,reduction
R361	T945	T944	compound	brain,malformations
R362	T946	T947	punct	[,6
R363	T947	T928	parataxis	6,result
R364	T948	T947	nummod	2,6
R365	T949	T947	punct	",",6
R366	T950	T947	punct	],6
R367	T951	T921	punct	.,are
R368	T953	T954	det	The,roles
R369	T954	T955	nsubjpass	roles,studied
R370	T956	T954	prep	of,roles
R371	T957	T956	pobj	PAX6,of
R372	T958	T954	prep	in,roles
R373	T959	T960	compound	brain,development
R374	T960	T958	pobj	development,in
R375	T961	T955	aux	have,studied
R376	T962	T955	advmod	mainly,studied
R377	T963	T955	auxpass	been,studied
R378	T964	T955	prep	in,studied
R379	T965	T966	amod	homozygous,mice
R380	T966	T964	pobj	mice,in
R381	T967	T966	compound	mutant,mice
R382	T968	T966	cc	or,mice
R383	T969	T966	conj	rats,mice
R384	T970	T955	cc	and,studied
R385	T971	T955	conj	include,studied
R386	T972	T971	dobj	arealisation,include
R387	T973	T972	prep	of,arealisation
R388	T974	T975	det	the,cortex
R389	T975	T973	pobj	cortex,of
R390	T976	T975	amod	cerebral,cortex
R391	T977	T978	punct	[,7
R392	T978	T972	parataxis	7,arealisation
R393	T979	T978	punct	],7
R394	T980	T972	punct	", ",arealisation
R395	T981	T972	conj	formation,arealisation
R396	T982	T981	prep	of,formation
R397	T983	T984	det	the,boundary
R398	T984	T982	pobj	boundary,of
R399	T985	T986	compound	prosencephalon,mesencephalon
R400	T986	T984	compound	mesencephalon,boundary
R401	T987	T986	punct	-,mesencephalon
R402	T988	T989	punct	[,8
R403	T989	T981	parataxis	8,formation
R404	T990	T989	punct	],8
R405	T991	T981	punct	", ",formation
R406	T992	T993	compound	axon,guidance
R407	T993	T981	conj	guidance,formation
R408	T994	T995	punct	[,8
R409	T995	T993	parataxis	8,guidance
R410	T996	T995	punct	],8
R411	T997	T993	punct	", ",guidance
R412	T998	T993	conj	differentiation,guidance
R413	T999	T998	prep	of,differentiation
R414	T1000	T999	pobj	neurons,of
R415	T1001	T998	prep	from,differentiation
R416	T1002	T1001	pobj	glia,from
R417	T1003	T1004	punct	[,9
R418	T1004	T998	parataxis	9,differentiation
R419	T1005	T1004	punct	],9
R420	T1006	T998	cc	and,differentiation
R421	T1007	T1008	amod	neuronal,migration
R422	T1008	T998	conj	migration,differentiation
R423	T1009	T1008	prep	in,migration
R424	T1010	T1011	det	the,cerebellum
R425	T1011	T1009	pobj	cerebellum,in
R426	T1012	T1013	punct	[,10
R427	T1013	T1008	parataxis	10,migration
R428	T1014	T1013	punct	],10
R429	T1015	T955	punct	.,studied
R430	T1017	T1018	det	The,discovery
R431	T1018	T1019	nsubj	discovery,prompted
R432	T1020	T1018	prep	of,discovery
R433	T1021	T1022	amod	multiple,roles
R434	T1022	T1020	pobj	roles,of
R435	T1023	T1021	cc	and,multiple
R436	T1024	T1021	conj	diverse,multiple
R437	T1025	T1022	prep	for,roles
R438	T1026	T1025	pobj	PAX6,for
R439	T1027	T1022	prep	in,roles
R440	T1028	T1029	compound	brain,development
R441	T1029	T1027	pobj	development,in
R442	T1030	T1031	compound	MRI,analyses
R443	T1031	T1019	dobj	analyses,prompted
R444	T1032	T1031	prep	of,analyses
R445	T1033	T1034	compound	aniridia,patients
R446	T1034	T1032	pobj	patients,of
R447	T1035	T1019	punct	", ",prompted
R448	T1036	T1019	cc	and,prompted
R449	T1037	T1038	det	a,range
R450	T1038	T1039	nsubjpass	range,uncovered
R451	T1039	T1019	conj	uncovered,prompted
R452	T1040	T1038	prep	of,range
R453	T1041	T1042	amod	distinctive,anomalies
R454	T1042	T1040	pobj	anomalies,of
R455	T1043	T1042	compound	brain,anomalies
R456	T1044	T1039	auxpass	were,uncovered
R457	T1045	T1039	punct	.,uncovered
R458	T1047	T1048	det	The,common
R459	T1048	T1050	nsubj	common,was
R460	T1049	T1048	advmod	most,common
R461	T1051	T1048	cc	and,common
R462	T1052	T1048	conj	striking,common
R463	T1053	T1048	prep	of,common
R464	T1054	T1053	pobj	these,of
R465	T1055	T1050	attr	absence,was
R466	T1056	T1055	cc	or,absence
R467	T1057	T1055	conj	hypoplasia,absence
R468	T1058	T1055	prep	of,absence
R469	T1059	T1060	det	the,commissure
R470	T1060	T1058	pobj	commissure,of
R471	T1061	T1060	amod	anterior,commissure
R472	T1062	T1063	punct	[,11
R473	T1063	T1050	parataxis	11,was
R474	T1064	T1063	punct	],11
R475	T1065	T1050	punct	.,was
R476	T1067	T1068	amod	Other,defects
R477	T1068	T1069	nsubj	defects,included
R478	T1070	T1069	dobj	absence,included
R479	T1071	T1070	cc	or,absence
R480	T1072	T1070	conj	hypoplasia,absence
R481	T1073	T1070	prep	of,absence
R482	T1074	T1075	det	the,gland
R483	T1075	T1073	pobj	gland,of
R484	T1076	T1075	amod	pineal,gland
R485	T1077	T1070	punct	", ",absence
R486	T1078	T1079	amod	cortical,polymicrogyria
R487	T1079	T1070	conj	polymicrogyria,absence
R488	T1080	T1079	punct	", ",polymicrogyria
R489	T1081	T1082	amod	white,matter
R490	T1082	T1083	compound	matter,changes
R491	T1083	T1079	conj	changes,polymicrogyria
R492	T1084	T1083	prep	in,changes
R493	T1085	T1086	det	the,callosum
R494	T1086	T1084	pobj	callosum,in
R495	T1087	T1086	compound	corpus,callosum
R496	T1088	T1083	cc	and,changes
R497	T1089	T1090	amod	grey,matter
R498	T1090	T1091	compound	matter,changes
R499	T1091	T1083	conj	changes,changes
R500	T1092	T1091	prep	in,changes
R501	T1093	T1094	det	the,cerebellum
R502	T1094	T1092	pobj	cerebellum,in
R503	T1095	T1096	punct	[,11
R504	T1096	T1069	parataxis	11,included
R505	T1097	T1098	punct	-,13
R506	T1098	T1096	prep	13,11
R507	T1099	T1096	punct	],11
R508	T1100	T1069	punct	.,included
R509	T1102	T1103	amod	Functional,changes
R510	T1103	T1104	nsubj	changes,included
R511	T1105	T1104	dobj	hyposmia,included
R512	T1106	T1105	cc	and,hyposmia
R513	T1107	T1108	amod	abnormal,transfer
R514	T1108	T1105	conj	transfer,hyposmia
R515	T1109	T1108	amod	inter-hemispheric,transfer
R516	T1110	T1108	amod	auditory,transfer
R517	T1111	T1112	punct	[,14
R518	T1112	T1104	parataxis	14,included
R519	T1113	T1112	nummod	11,14
R520	T1114	T1112	punct	",",14
R521	T1115	T1112	punct	],14
R522	T1116	T1104	punct	.,included
R523	T1118	T1119	det	The,feature
R524	T1119	T1121	nsubj	feature,is
R525	T1120	T1119	amod	defining,feature
R526	T1122	T1119	prep	of,feature
R527	T1123	T1124	det	all,proteins
R528	T1124	T1122	pobj	proteins,of
R529	T1125	T1124	compound	PAX,proteins
R530	T1126	T1127	det	the,presence
R531	T1127	T1121	attr	presence,is
R532	T1128	T1127	prep	of,presence
R533	T1129	T1130	det	a,domain
R534	T1130	T1128	pobj	domain,of
R535	T1131	T1132	nummod	128,acid
R536	T1132	T1130	nmod	acid,domain
R537	T1133	T1132	nmod	amino,acid
R538	T1134	T1135	npadvmod	DNA,binding
R539	T1135	T1130	amod	binding,domain
R540	T1136	T1135	punct	-,binding
R541	T1137	T1130	amod	paired,domain
R542	T1138	T1139	dep	that,conserved
R543	T1139	T1130	relcl	conserved,domain
R544	T1140	T1139	aux	has,conserved
R545	T1141	T1139	auxpass	been,conserved
R546	T1142	T1139	advmod	highly,conserved
R547	T1143	T1139	prep	over,conserved
R548	T1144	T1143	pobj	evolution,over
R549	T1145	T1146	punct	[,1
R550	T1146	T1127	parataxis	1,presence
R551	T1147	T1146	punct	],1
R552	T1148	T1121	punct	.,is
R553	T1150	T1151	prep	In,contains
R554	T1152	T1150	pobj	addition,In
R555	T1153	T1152	prep	to,addition
R556	T1154	T1155	det	the,domain
R557	T1155	T1153	pobj	domain,to
R558	T1156	T1155	amod	paired,domain
R559	T1157	T1151	punct	", ",contains
R560	T1158	T1151	nsubj	PAX6,contains
R561	T1159	T1151	advmod	also,contains
R562	T1160	T1161	det	a,homeodomain
R563	T1161	T1151	dobj	homeodomain,contains
R564	T1162	T1163	npadvmod	DNA,binding
R565	T1163	T1161	amod	binding,homeodomain
R566	T1164	T1163	punct	-,binding
R567	T1165	T1161	cc	and,homeodomain
R568	T1166	T1167	det	a,domain
R569	T1167	T1161	conj	domain,homeodomain
R570	T1168	T1169	npadvmod	proline,rich
R571	T1169	T1167	amod	rich,domain
R572	T1170	T1168	punct	", ",proline
R573	T1171	T1168	conj	serine,proline
R574	T1172	T1171	cc	and,serine
R575	T1173	T1171	conj	threonine,serine
R576	T1174	T1169	punct	-,rich
R577	T1175	T1176	punct	(,PST
R578	T1176	T1167	parataxis	PST,domain
R579	T1177	T1176	punct	),PST
R580	T1178	T1151	prep	at,contains
R581	T1179	T1180	det	the,terminus
R582	T1180	T1178	pobj	terminus,at
R583	T1181	T1180	compound	C,terminus
R584	T1182	T1180	punct	-,terminus
R585	T1183	T1184	punct	[,6
R586	T1184	T1151	parataxis	6,contains
R587	T1185	T1184	nummod	1,6
R588	T1186	T1184	punct	",",6
R589	T1187	T1184	punct	],6
R590	T1188	T1151	punct	.,contains
R591	T1190	T1191	det	The,domain
R592	T1191	T1193	nsubjpass	domain,shown
R593	T1192	T1191	compound	PST,domain
R594	T1194	T1191	punct	", ",domain
R595	T1195	T1196	dep	which,encompasses
R596	T1196	T1191	relcl	encompasses,domain
R597	T1197	T1198	det	the,acids
R598	T1198	T1196	dobj	acids,encompasses
R599	T1199	T1200	npadvmod	C,terminal
R600	T1200	T1198	amod	terminal,acids
R601	T1201	T1200	punct	-,terminal
R602	T1202	T1198	nummod	145,acids
R603	T1203	T1198	compound	amino,acids
R604	T1204	T1198	prep	of,acids
R605	T1205	T1204	pobj	PAX6,of
R606	T1206	T1193	punct	", ",shown
R607	T1207	T1193	aux	has,shown
R608	T1208	T1193	auxpass	been,shown
R609	T1209	T1210	aux	to,act
R610	T1210	T1193	xcomp	act,shown
R611	T1211	T1210	prep	as,act
R612	T1212	T1213	det	a,activator
R613	T1213	T1211	pobj	activator,as
R614	T1214	T1213	amod	transcriptional,activator
R615	T1215	T1216	punct	[,6
R616	T1216	T1193	parataxis	6,shown
R617	T1217	T1216	punct	],6
R618	T1218	T1193	punct	.,shown
R619	T1220	T1221	det	The,protein
R620	T1221	T1223	nsubj	protein,regulates
R621	T1222	T1221	compound	PAX6,protein
R622	T1224	T1223	advmod	directly,regulates
R623	T1225	T1226	det	a,range
R624	T1226	T1223	dobj	range,regulates
R625	T1227	T1226	amod	wide,range
R626	T1228	T1226	prep	of,range
R627	T1229	T1230	compound	target,genes
R628	T1230	T1228	pobj	genes,of
R629	T1231	T1232	punct	[,2
R630	T1232	T1230	parataxis	2,genes
R631	T1233	T1232	nummod	1,2
R632	T1234	T1232	punct	",",2
R633	T1235	T1232	punct	],2
R634	T1236	T1226	prep	including,range
R635	T1237	T1236	pobj	Pax2,including
R636	T1238	T1239	punct	[,15
R637	T1239	T1237	parataxis	15,Pax2
R638	T1240	T1239	punct	],15
R639	T1241	T1237	punct	", ",Pax2
R640	T1242	T1237	conj	Ngn2,Pax2
R641	T1243	T1244	punct	[,16
R642	T1244	T1242	parataxis	16,Ngn2
R643	T1245	T1244	punct	],16
R644	T1246	T1242	cc	and,Ngn2
R645	T1247	T1242	conj	glucagon,Ngn2
R646	T1248	T1249	punct	[,17
R647	T1249	T1247	parataxis	17,glucagon
R648	T1250	T1249	punct	],17
R649	T1251	T1223	punct	.,regulates
R650	T1253	T1254	det	The,gene
R651	T1254	T1256	nsubj	gene,has
R652	T1255	T1254	compound	Pax6,gene
R653	T1257	T1258	det	a,pattern
R654	T1258	T1256	dobj	pattern,has
R655	T1259	T1260	advmod	spatially,complex
R656	T1260	T1258	amod	complex,pattern
R657	T1261	T1259	cc	and,spatially
R658	T1262	T1259	conj	temporally,spatially
R659	T1263	T1258	compound	expression,pattern
R660	T1264	T1256	prep	in,has
R661	T1265	T1266	det	the,eye
R662	T1266	T1264	pobj	eye,in
R663	T1267	T1266	punct	", ",eye
R664	T1268	T1266	conj	brain,eye
R665	T1269	T1268	punct	", ",brain
R666	T1270	T1271	amod	nasal,structures
R667	T1271	T1268	conj	structures,brain
R668	T1272	T1271	punct	", ",structures
R669	T1273	T1274	amod	spinal,cord
R670	T1274	T1271	conj	cord,structures
R671	T1275	T1274	cc	and,cord
R672	T1276	T1274	conj	pancreas,cord
R673	T1277	T1278	punct	[,1
R674	T1278	T1256	parataxis	1,has
R675	T1279	T1278	punct	],1
R676	T1280	T1256	punct	.,has
R677	T1282	T1283	mark	Although,involved
R678	T1283	T1287	advcl	involved,emerging
R679	T1284	T1283	nsubjpass	PAX6,involved
R680	T1285	T1283	auxpass	is,involved
R681	T1286	T1283	advmod	clearly,involved
R682	T1288	T1283	prep	in,involved
R683	T1289	T1290	amod	multiple,processes
R684	T1290	T1288	pobj	processes,in
R685	T1291	T1290	amod	developmental,processes
R686	T1292	T1287	punct	", ",emerging
R687	T1293	T1294	amod	common,themes
R688	T1294	T1287	nsubj	themes,emerging
R689	T1295	T1287	aux	are,emerging
R690	T1296	T1287	advmod	now,emerging
R691	T1297	T1287	prep	concerning,emerging
R692	T1298	T1299	det	the,role
R693	T1299	T1297	pobj	role,concerning
R694	T1300	T1299	prep	of,role
R695	T1301	T1300	pobj	PAX6,of
R696	T1302	T1299	prep	in,role
R697	T1303	T1304	amod	neural,tissues
R698	T1304	T1302	pobj	tissues,in
R699	T1305	T1287	punct	.,emerging
R700	T1307	T1308	nsubj	Gradients,are
R701	T1309	T1307	prep	of,Gradients
R702	T1310	T1311	compound	Pax6,expression
R703	T1311	T1309	pobj	expression,of
R704	T1312	T1308	acomp	important,are
R705	T1313	T1312	prep	for,important
R706	T1314	T1313	pcomp	determining,for
R707	T1315	T1316	amod	positional,characteristics
R708	T1316	T1314	dobj	characteristics,determining
R709	T1317	T1314	prep	in,determining
R710	T1318	T1319	det	the,retina
R711	T1319	T1317	pobj	retina,in
R712	T1320	T1321	punct	[,18
R713	T1321	T1319	parataxis	18,retina
R714	T1322	T1321	punct	],18
R715	T1323	T1319	cc	and,retina
R716	T1324	T1325	det	the,neocortex
R717	T1325	T1319	conj	neocortex,retina
R718	T1326	T1327	punct	[,7
R719	T1327	T1325	parataxis	7,neocortex
R720	T1328	T1327	punct	],7
R721	T1329	T1308	punct	.,are
R722	T1331	T1332	nsubj	PAX6,plays
R723	T1333	T1334	det	a,role
R724	T1334	T1332	dobj	role,plays
R725	T1335	T1332	prep	in,plays
R726	T1336	T1335	pobj	development,in
R727	T1337	T1336	prep	of,development
R728	T1338	T1339	amod	specific,connections
R729	T1339	T1337	pobj	connections,of
R730	T1340	T1339	amod	axonal,connections
R731	T1341	T1339	prep	between,connections
R732	T1342	T1343	det	the,retina
R733	T1343	T1341	pobj	retina,between
R734	T1344	T1343	cc	and,retina
R735	T1345	T1346	det	the,brain
R736	T1346	T1343	conj	brain,retina
R737	T1347	T1348	punct	[,18
R738	T1348	T1346	parataxis	18,brain
R739	T1349	T1348	punct	],18
R740	T1350	T1341	cc	and,between
R741	T1351	T1341	conj	within,between
R742	T1352	T1353	det	the,forebrain
R743	T1353	T1351	pobj	forebrain,within
R744	T1354	T1355	punct	[,19
R745	T1355	T1353	parataxis	19,forebrain
R746	T1356	T1355	nummod	8,19
R747	T1357	T1355	punct	",",19
R748	T1358	T1355	punct	],19
R749	T1359	T1332	punct	.,plays
R750	T1361	T1362	nsubjpass	It,involved
R751	T1363	T1362	auxpass	is,involved
R752	T1364	T1362	advmod	also,involved
R753	T1365	T1362	prep	in,involved
R754	T1366	T1367	det	the,differentiation
R755	T1367	T1365	pobj	differentiation,in
R756	T1368	T1367	prep	of,differentiation
R757	T1369	T1370	amod	neural,types
R758	T1370	T1368	pobj	types,of
R759	T1371	T1370	compound	cell,types
R760	T1372	T1367	prep	from,differentiation
R761	T1373	T1374	amod	multipotent,precursors
R762	T1374	T1372	pobj	precursors,from
R763	T1375	T1367	prep	in,differentiation
R764	T1376	T1377	det	the,retina
R765	T1377	T1375	pobj	retina,in
R766	T1378	T1379	punct	[,16
R767	T1379	T1377	parataxis	16,retina
R768	T1380	T1379	punct	],16
R769	T1381	T1377	cc	and,retina
R770	T1382	T1383	det	the,cortex
R771	T1383	T1377	conj	cortex,retina
R772	T1384	T1383	amod	cerebral,cortex
R773	T1385	T1386	punct	[,9
R774	T1386	T1383	parataxis	9,cortex
R775	T1387	T1386	punct	],9
R776	T1388	T1362	prep	through,involved
R777	T1389	T1388	pobj	activation,through
R778	T1390	T1389	prep	of,activation
R779	T1391	T1392	compound	bHLH,genes
R780	T1392	T1390	pobj	genes,of
R781	T1393	T1394	amod	such,as
R782	T1394	T1392	prep	as,genes
R783	T1395	T1394	pobj	Ngn2,as
R784	T1396	T1395	cc	and,Ngn2
R785	T1397	T1395	conj	Mash1,Ngn2
R786	T1398	T1362	punct	.,involved
R787	T1400	T1401	det	These,studies
R788	T1401	T1402	nsubj	studies,provide
R789	T1403	T1404	det	a,link
R790	T1404	T1402	dobj	link,provide
R791	T1405	T1404	amod	clear,link
R792	T1406	T1404	prep	between,link
R793	T1407	T1408	compound	PAX6,function
R794	T1408	T1406	pobj	function,between
R795	T1409	T1408	prep	in,function
R796	T1410	T1411	det	the,retina
R797	T1411	T1409	pobj	retina,in
R798	T1412	T1411	cc	and,retina
R799	T1413	T1414	det	the,brain
R800	T1414	T1411	conj	brain,retina
R801	T1415	T1402	punct	", ",provide
R802	T1416	T1402	cc	and,provide
R803	T1417	T1402	conj	are,provide
R804	T1418	T1417	prep	of,are
R805	T1419	T1420	amod	particular,relevance
R806	T1420	T1418	pobj	relevance,of
R807	T1421	T1420	prep	to,relevance
R808	T1422	T1423	det	the,phenotypes
R809	T1423	T1421	pobj	phenotypes,to
R810	T1424	T1423	amod	neurological,phenotypes
R811	T1425	T1423	prep	of,phenotypes
R812	T1426	T1425	pobj	individuals,of
R813	T1427	T1426	prep	with,individuals
R814	T1428	T1429	compound	PAX6,mutations
R815	T1429	T1427	pobj	mutations,with
R816	T1430	T1402	punct	.,provide
R817	T1432	T1433	nsubj	It,becoming
R818	T1434	T1433	aux	is,becoming
R819	T1435	T1433	acomp	apparent,becoming
R820	T1436	T1437	mark	that,act
R821	T1437	T1433	ccomp	act,becoming
R822	T1438	T1439	compound	transcription,factors
R823	T1439	T1437	nsubj	factors,act
R824	T1440	T1437	aux	do,act
R825	T1441	T1437	neg	not,act
R826	T1442	T1437	prep	in,act
R827	T1443	T1442	pobj	isolation,in
R828	T1444	T1437	cc	but,act
R829	T1445	T1437	conj	are,act
R830	T1446	T1445	acomp	dependent,are
R831	T1447	T1446	prep	on,dependent
R832	T1448	T1447	pobj	interactions,on
R833	T1449	T1448	prep	with,interactions
R834	T1450	T1451	amod	other,proteins
R835	T1451	T1449	pobj	proteins,with
R836	T1452	T1453	aux	to,carry
R837	T1453	T1445	advcl	carry,are
R838	T1454	T1453	prt	out,carry
R839	T1455	T1456	poss	their,function
R840	T1456	T1453	dobj	function,carry
R841	T1457	T1458	punct	[,21
R842	T1458	T1445	parataxis	21,are
R843	T1459	T1458	nummod	20,21
R844	T1460	T1458	punct	",",21
R845	T1461	T1458	punct	],21
R846	T1462	T1433	punct	.,becoming
R847	T1464	T1465	det	These,interactions
R848	T1465	T1466	nsubj	interactions,introduce
R849	T1467	T1468	amod	more,specificity
R850	T1468	T1466	dobj	specificity,introduce
R851	T1469	T1466	prep	into,introduce
R852	T1470	T1471	det	the,function
R853	T1471	T1469	pobj	function,into
R854	T1472	T1471	amod	regulatory,function
R855	T1473	T1471	prep	of,function
R856	T1474	T1475	det	a,factor
R857	T1475	T1473	pobj	factor,of
R858	T1476	T1475	amod	given,factor
R859	T1477	T1475	compound	transcription,factor
R860	T1478	T1466	punct	.,introduce
R861	T1480	T1481	prep	To,described
R862	T1482	T1480	pobj	date,To
R863	T1483	T1484	advmod	only,interactions
R864	T1484	T1481	nsubjpass	interactions,described
R865	T1485	T1484	nummod	three,interactions
R866	T1486	T1484	nmod	PAX6,interactions
R867	T1487	T1488	nmod	protein,protein
R868	T1488	T1484	compound	protein,interactions
R869	T1489	T1488	punct	-,protein
R870	T1490	T1481	aux	have,described
R871	T1491	T1481	auxpass	been,described
R872	T1492	T1481	punct	: ,described
R873	T1493	T1481	prep	with,described
R874	T1494	T1493	pobj	SOX2,with
R875	T1495	T1494	prep	on,SOX2
R876	T1496	T1497	det	the,element
R877	T1497	T1495	pobj	element,on
R878	T1498	T1499	npadvmod	lens,specific
R879	T1499	T1497	amod	specific,element
R880	T1500	T1499	punct	-,specific
R881	T1501	T1497	compound	enhancer,element
R882	T1502	T1497	prep	of,element
R883	T1503	T1504	det	the,gene
R884	T1504	T1502	pobj	gene,of
R885	T1505	T1506	punct	δ,crystallin
R886	T1506	T1504	compound	crystallin,gene
R887	T1507	T1506	punct	-,crystallin
R888	T1508	T1509	punct	[,22
R889	T1509	T1493	parataxis	22,with
R890	T1510	T1509	punct	],22
R891	T1511	T1493	punct	;,with
R892	T1512	T1493	conj	with,with
R893	T1513	T1512	pobj	MDIA,with
R894	T1514	T1513	punct	", ",MDIA
R895	T1515	T1516	dep	which,modulates
R896	T1516	T1513	relcl	modulates,MDIA
R897	T1517	T1518	compound	PAX6,activity
R898	T1518	T1516	dobj	activity,modulates
R899	T1519	T1516	prep	in,modulates
R900	T1520	T1521	amod	early,development
R901	T1521	T1519	pobj	development,in
R902	T1522	T1521	amod	neuronal,development
R903	T1523	T1524	punct	[,23
R904	T1524	T1513	parataxis	23,MDIA
R905	T1525	T1524	punct	],23
R906	T1526	T1512	punct	", ",with
R907	T1527	T1512	cc	and,with
R908	T1528	T1512	conj	with,with
R909	T1529	T1530	compound	MAF,proteins
R910	T1530	T1528	pobj	proteins,with
R911	T1531	T1530	prep	on,proteins
R912	T1532	T1533	det	the,promoter
R913	T1613	T1614	nummod	two,hybrid
R914	T1533	T1531	pobj	promoter,on
R915	T1534	T1533	compound	glucagon,promoter
R916	T1614	T1611	compound	hybrid,technique
R917	T1615	T1614	punct	-,hybrid
R918	T1535	T1533	punct	", ",promoter
R919	T1616	T1601	cc	and,screened
R920	T1617	T1601	conj	identified,screened
R921	T1618	T1619	nummod	three,proteins
R922	T1536	T1537	dep	which,causes
R923	T1619	T1617	dobj	proteins,identified
R924	T1620	T1619	amod	novel,proteins
R925	T1537	T1533	relcl	causes,promoter
R926	T1621	T1619	amod	interacting,proteins
R927	T1622	T1619	punct	", ",proteins
R928	T1623	T1619	appos	HOMER3,proteins
R929	T1624	T1623	punct	", ",HOMER3
R930	T1625	T1623	conj	DNCL1,HOMER3
R931	T1626	T1625	cc	and,DNCL1
R932	T1538	T1539	amod	increased,expression
R933	T1627	T1625	conj	TRIM11,DNCL1
R934	T1628	T1601	punct	.,screened
R935	T1539	T1537	dobj	expression,causes
R936	T1630	T1631	det	The,interaction
R937	T1631	T1632	nsubjpass	interaction,disrupted
R938	T1540	T1539	prep	of,expression
R939	T1633	T1631	prep	between,interaction
R940	T1634	T1633	pobj	PAX6,between
R941	T1541	T1542	det	this,gene
R942	T1635	T1634	cc	and,PAX6
R943	T1636	T1637	det	these,proteins
R944	T1542	T1540	pobj	gene,of
R945	T1637	T1634	conj	proteins,PAX6
R946	T1638	T1632	auxpass	was,disrupted
R947	T1639	T1632	agent	by,disrupted
R948	T1543	T1542	amod	pancreatic,gene
R949	T1640	T1641	advmod	naturally,occurring
R950	T1641	T1642	amod	occurring,mutations
R951	T1544	T1542	compound	hormone,gene
R952	T1545	T1546	punct	[,17
R953	T1642	T1639	pobj	mutations,by
R954	T1643	T1644	npadvmod	C,terminal
R955	T1546	T1528	parataxis	17,with
R956	T1644	T1642	amod	terminal,mutations
R957	T1547	T1546	punct	],17
R958	T1645	T1644	punct	-,terminal
R959	T1646	T1642	compound	PAX6,mutations
R960	T1647	T1632	punct	.,disrupted
R961	T1548	T1481	punct	.,described
R962	T1550	T1551	advmod	Here,report
R963	T1552	T1551	nsubj	we,report
R964	T1553	T1554	det	the,results
R965	T1554	T1551	dobj	results,report
R966	T1555	T1554	amod	preliminary,results
R967	T1556	T1554	prep	of,results
R968	T1557	T1558	det	the,screen
R969	T1558	T1556	pobj	screen,of
R970	T1559	T1558	amod	first,screen
R971	T1560	T1558	amod	systematic,screen
R972	T1561	T1558	prep	for,screen
R973	T1562	T1561	pobj	proteins,for
R974	T1563	T1564	dep	that,interact
R975	T1564	T1562	relcl	interact,proteins
R976	T1565	T1564	prep	with,interact
R977	T1566	T1565	pobj	PAX6,with
R978	T1567	T1551	punct	.,report
R979	T1569	T1570	nsubj	We,used
R980	T1571	T1572	compound	sequence,alignment
R981	T1572	T1573	compound	alignment,algorithms
R982	T1573	T1570	dobj	algorithms,used
R983	T1574	T1573	cc	and,algorithms
R984	T1575	T1576	amod	secondary,structure
R985	T1576	T1577	compound	structure,prediction
R986	T1577	T1578	compound	prediction,programs
R987	T1578	T1573	conj	programs,algorithms
R988	T1579	T1580	aux	to,define
R989	T1580	T1570	advcl	define,used
R990	T1581	T1582	det	a,domain
R991	T1582	T1580	dobj	domain,define
R992	T1583	T1582	amod	new,domain
R993	T1584	T1582	prep	of,domain
R994	T1585	T1586	nummod	32,acids
R995	T1586	T1584	pobj	acids,of
R996	T1587	T1586	compound	amino,acids
R997	T1588	T1580	prep	at,define
R998	T1589	T1590	det	the,end
R999	T1590	T1588	pobj	end,at
R1000	T1591	T1592	npadvmod	C,terminal
R1001	T1592	T1590	amod	terminal,end
R1002	T1593	T1592	punct	-,terminal
R1003	T1594	T1590	prep	of,end
R1004	T1595	T1596	det	the,protein
R1005	T1596	T1594	pobj	protein,of
R1006	T1597	T1596	compound	PAX6,protein
R1007	T1598	T1570	punct	.,used
R1008	T1600	T1601	nsubj	We,screened
R1009	T1602	T1601	advmod	then,screened
R1010	T1603	T1604	det	a,library
R1011	T1604	T1601	dobj	library,screened
R1012	T1605	T1604	compound	brain,library
R1013	T1606	T1601	prep	with,screened
R1014	T1607	T1608	det	this,peptide
R1015	T1608	T1606	pobj	peptide,with
R1016	T1609	T1601	advcl	using,screened
R1017	T1610	T1611	det	the,technique
R1018	T1611	T1609	dobj	technique,using
R1019	T1612	T1611	nmod	yeast,technique
R1020	T1765	T1766	det	A,peptide
R1021	T1767	T1768	advmod	highly,conserved
R1022	T1768	T1766	amod	conserved,peptide
R1023	T1769	T1770	npadvmod	C,terminal
R1024	T1770	T1766	amod	terminal,peptide
R1025	T1771	T1770	punct	-,terminal
R1026	T1772	T1766	compound	PAX6,peptide
R1027	T1774	T1775	nsubj	We,noted
R1028	T1776	T1774	cc	and,We
R1029	T1777	T1774	conj	others,We
R1030	T1778	T1779	punct	[,31
R1031	T1779	T1777	parataxis	31,others
R1032	T1780	T1781	punct	-,33
R1033	T1781	T1779	prep	33,31
R1034	T1782	T1779	punct	],31
R1035	T1783	T1784	mark	that,is
R1036	T1784	T1775	ccomp	is,noted
R1037	T1785	T1784	expl	there,is
R1038	T1786	T1787	amod	significant,conservation
R1039	T1787	T1784	attr	conservation,is
R1040	T1788	T1787	compound	sequence,conservation
R1041	T1789	T1784	prep	at,is
R1042	T1790	T1791	det	the,end
R1043	T1791	T1789	pobj	end,at
R1044	T1792	T1793	npadvmod	C,terminal
R1045	T1793	T1791	amod	terminal,end
R1046	T1794	T1793	punct	-,terminal
R1047	T1795	T1791	prep	of,end
R1048	T1796	T1797	det	the,protein
R1049	T1797	T1795	pobj	protein,of
R1050	T1798	T1797	compound	PAX6,protein
R1051	T1799	T1775	punct	.,noted
R1052	T1801	T1802	compound	BLAST,analysis
R1053	T1802	T1803	nsubj	analysis,revealed
R1054	T1804	T1802	prep	of,analysis
R1055	T1805	T1806	det	the,sequence
R1056	T1806	T1804	pobj	sequence,of
R1057	T1807	T1808	compound	amino,acid
R1058	T1808	T1806	compound	acid,sequence
R1059	T1809	T1806	prep	of,sequence
R1060	T1810	T1811	det	the,domain
R1061	T1811	T1809	pobj	domain,of
R1062	T1812	T1811	compound	PAX6,domain
R1063	T1813	T1811	compound	PST,domain
R1064	T1814	T1815	punct	(,278
R1065	T1815	T1806	parataxis	278,sequence
R1066	T1816	T1815	nmod	aa,278
R1067	T1817	T1818	punct	–,422
R1068	T1818	T1815	prep	422,278
R1100	T1852	T1853	amod	such,as
R1101	T1853	T1851	prep	as,species
R1102	T1854	T1853	pobj	axolotl,as
R1103	T1855	T1854	punct	(,axolotl
R1104	T1856	T1857	compound	Ambystoma,mexicanum
R1105	T1857	T1854	appos	mexicanum,axolotl
R1106	T1858	T1854	punct	),axolotl
R1107	T1859	T1854	cc	and,axolotl
R1108	T1860	T1861	compound	sea,urchin
R1109	T1861	T1854	conj	urchin,axolotl
R1110	T1862	T1861	punct	(,urchin
R1111	T1863	T1864	compound	Paracentrotus,lividus
R1112	T1864	T1861	appos	lividus,urchin
R1113	T1865	T1846	punct	),seen
R1114	T1866	T1867	punct	(,Figure
R1115	T1867	T1846	parataxis	Figure,seen
R1116	T1868	T1867	nummod	1a,Figure
R1117	T1869	T1867	punct	),Figure
R1118	T1870	T1846	punct	.,seen
R1137	T1891	T1889	dobj	number,uses
R1138	T1892	T1891	prep	of,number
R1139	T1893	T1894	amod	different,algorithms
R1140	T1894	T1892	pobj	algorithms,of
R1141	T1895	T1896	compound	protein,structure
R1142	T1896	T1897	compound	structure,prediction
R1143	T1897	T1894	compound	prediction,algorithms
R1144	T1898	T1899	aux	to,generate
R1145	T1899	T1889	advcl	generate,uses
R1146	T1900	T1901	det	a,structure
R1147	T1901	T1899	dobj	structure,generate
R1148	T1902	T1901	nmod	consensus,structure
R1149	T1903	T1901	amod	secondary,structure
R1150	T1904	T1905	punct	(,Figure
R1151	T1905	T1873	parataxis	Figure,subjected
R1152	T1906	T1905	nummod	1,Figure
R1153	T1907	T1905	punct	),Figure
R1154	T1908	T1909	punct	[,26
R1155	T1909	T1873	parataxis	26,subjected
R1156	T1910	T1909	nummod	25,26
R1157	T1911	T1909	punct	",",26
R1158	T1912	T1909	punct	],26
R1159	T1913	T1873	punct	.,subjected
R1160	T1915	T1916	det	The,domain
R1161	T1916	T1918	nsubj	domain,was
R1162	T1917	T1916	compound	PST,domain
R1163	T1919	T1918	advmod	largely,was
R1164	T1920	T1918	acomp	devoid,was
R1165	T1921	T1920	prep	of,devoid
R1166	T1922	T1923	amod	predicted,structure
R1167	T1923	T1921	pobj	structure,of
R1168	T1924	T1923	amod	secondary,structure
R1169	T1925	T1918	prep	except,was
R1170	T1926	T1925	prep	for,except
R1171	T1927	T1928	det	the,region
R1172	T1928	T1926	pobj	region,for
R1173	T1929	T1930	npadvmod	C,terminal
R1174	T1930	T1928	amod	terminal,region
R1175	T1931	T1930	punct	-,terminal
R1176	T1932	T1928	punct	", ",region
R1177	T1933	T1934	dep	which,contained
R1178	T1934	T1928	relcl	contained,region
R1179	T1935	T1936	nummod	two,sheets
R1180	T1936	T1934	dobj	sheets,contained
R1181	T1937	T1936	amod	predicted,sheets
R1182	T1938	T1936	compound	beta,sheets
R1183	T1939	T1936	prep	within,sheets
R1184	T1940	T1941	det	the,domain
R1185	T1941	T1939	pobj	domain,within
R1186	T1942	T1941	advmod	highly,domain
R1187	T1943	T1941	amod	conserved,domain
R1188	T1944	T1936	punct	", ",sheets
R1189	T1945	T1936	appos	one,sheets
R1190	T1946	T1945	prep	in,one
R1191	T1947	T1948	det	the,GLISP
R1192	T1948	T1950	nmod	GLISP,motif
R1193	T1949	T1948	punct	',GLISP
R1194	T1950	T1946	pobj	motif,in
R1195	T1951	T1950	punct	',motif
R1196	T1952	T1945	cc	and,one
R1197	T1953	T1945	conj	one,one
R1198	T1954	T1953	prep	in,one
R1199	T1955	T1956	det	the,SPVPQ
R1200	T1956	T1958	nmod	SPVPQ,motif
R1201	T1957	T1956	punct	',SPVPQ
R1202	T1958	T1954	pobj	motif,in
R1203	T1959	T1958	punct	',motif
R1204	T1960	T1961	punct	(,identical
R1205	T1961	T1918	parataxis	identical,was
R1206	T1962	T1961	prep	to,identical
R1207	T1963	T1964	det	the,pattern
R1208	T1964	T1962	pobj	pattern,to
R1209	T1965	T1964	acl	shown,pattern
R1210	T1966	T1965	prep	in,shown
R1211	T1967	T1966	pobj	Figure,in
R1212	T1968	T1967	nummod	1c,Figure
R1213	T1969	T1961	punct	),identical
R1214	T1970	T1918	punct	.,was
R1215	T1972	T1973	advmod	Initially,defined
R1216	T1974	T1973	nsubj	we,defined
R1217	T1975	T1976	det	the,domain
R1218	T1976	T1973	dobj	domain,defined
R1219	T1977	T1978	npadvmod	C,terminal
R1220	T1978	T1976	amod	terminal,domain
R1221	T1979	T1978	punct	-,terminal
R1222	T1980	T1973	prep	as,defined
R1223	T1981	T1980	pcomp	running,as
R1224	T1982	T1981	prep	from,running
R1225	T1983	T1984	det	the,GLISP
R1226	T1984	T1986	nmod	GLISP,motif
R1227	T1985	T1984	punct	',GLISP
R1228	T1986	T1982	pobj	motif,from
R1229	T1987	T1984	punct	',GLISP
R1230	T1988	T1981	prep	up,running
R1231	T1989	T1988	prep	to,up
R1232	T1990	T1991	det	the,codon
R1233	T1991	T1989	pobj	codon,to
R1234	T1992	T1991	compound	stop,codon
R1235	T1993	T1973	punct	", ",defined
R1236	T1994	T1995	mark	since,conserved
R1237	T1995	T1973	advcl	conserved,defined
R1238	T1996	T1997	det	this,region
R1239	T1997	T1995	nsubjpass	region,conserved
R1240	T1998	T1995	auxpass	was,conserved
R1241	T1999	T2000	advmod	most,highly
R1242	T2000	T1995	advmod	highly,conserved
R1243	T2001	T1995	cc	and,conserved
R1244	T2002	T1995	conj	contained,conserved
R1245	T2003	T2004	advmod	strongly,predicted
R1246	T2004	T2005	amod	predicted,elements
R1247	T2005	T2002	dobj	elements,contained
R1248	T2006	T2007	amod	secondary,structure
R1249	T2007	T2005	compound	structure,elements
R1250	T2008	T1973	punct	.,defined
R1251	T2010	T2011	advmod	However,lost
R1252	T2012	T2013	advmod	when,performed
R1253	T2013	T2011	advcl	performed,lost
R1254	T2014	T2013	nsubj	we,performed
R1255	T2015	T2016	amod	secondary,structure
R1256	T2016	T2017	compound	structure,prediction
R1257	T2017	T2018	compound	prediction,analysis
R1258	T2018	T2013	dobj	analysis,performed
R1259	T2019	T2013	prep	on,performed
R1260	T2020	T2021	det	this,peptide
R1261	T2021	T2019	pobj	peptide,on
R1262	T2022	T2023	nummod	28,acid
R1263	T2023	T2021	compound	acid,peptide
R1264	T2024	T2023	compound	amino,acid
R1265	T2025	T2011	punct	", ",lost
R1266	T2026	T2027	det	the,sheet
R1267	T2027	T2011	nsubjpass	sheet,lost
R1268	T2028	T2027	amod	first,sheet
R1269	T2029	T2027	compound	beta,sheet
R1270	T2030	T2011	auxpass	was,lost
R1271	T2031	T2032	punct	(,Figure
R1272	T2032	T2011	parataxis	Figure,lost
R1273	T2033	T2032	nummod	1b,Figure
R1274	T2034	T2032	punct	),Figure
R1275	T2035	T2011	punct	.,lost
R1276	T2037	T2038	nsubj	Addition,caused
R1277	T2039	T2037	prep	of,Addition
R1278	T2040	T2041	det	another,acids
R1279	T2041	T2039	pobj	acids,of
R1280	T2042	T2041	nummod	4,acids
R1281	T2043	T2041	compound	amino,acids
R1282	T2044	T2045	punct	(,TTST
R1283	T2045	T2037	parataxis	TTST,Addition
R1284	T2046	T2045	punct	),TTST
R1285	T2047	T2048	advmod	immediately,before
R1286	T2048	T2037	prep	before,Addition
R1287	T2049	T2050	punct	',GLISP
R1288	T2050	T2048	pobj	GLISP,before
R1289	T2051	T2050	punct	',GLISP
R1290	T2052	T2038	dobj	recovery,caused
R1291	T2053	T2052	prep	of,recovery
R1292	T2054	T2055	det	the,sheet
R1293	T2055	T2053	pobj	sheet,of
R1294	T2056	T2055	amod	first,sheet
R1295	T2057	T2055	compound	beta,sheet
R1296	T2058	T2059	punct	(,Figure
R1297	T2059	T2038	parataxis	Figure,caused
R1298	T2060	T2059	nummod	1c,Figure
R1299	T2061	T2059	punct	),Figure
R1300	T2062	T2038	punct	.,caused
R1301	T2064	T2065	mark	Although,are
R1302	T2065	T2069	advcl	are,appear
R1303	T2066	T2067	det	these,residues
R1304	T2067	T2065	nsubj	residues,are
R1305	T2068	T2067	nummod	4,residues
R1306	T2070	T2065	neg	not,are
R1307	T2071	T2072	advmod	highly,conserved
R1308	T2072	T2065	acomp	conserved,are
R1309	T2073	T2074	punct	(,Figure
R1310	T2074	T2065	parataxis	Figure,are
R1311	T2075	T2074	nummod	1a,Figure
R1312	T2076	T2074	punct	),Figure
R1313	T2077	T2069	punct	", ",appear
R1314	T2078	T2069	nsubj	they,appear
R1315	T2079	T2080	aux	to,be
R1316	T2080	T2069	xcomp	be,appear
R1317	T2081	T2080	acomp	important,be
R1318	T2082	T2081	prep	for,important
R1319	T2083	T2082	pcomp	seeding,for
R1320	T2084	T2085	det	the,sheet
R1321	T2085	T2083	dobj	sheet,seeding
R1322	T2086	T2085	amod	first,sheet
R1323	T2087	T2085	compound	beta,sheet
R1324	T2088	T2082	cc	and,for
R1325	T2089	T2090	advmod	therefore,for
R1326	T2090	T2082	conj	for,for
R1327	T2091	T2092	amod	secondary,structure
R1328	T2092	T2090	pobj	structure,for
R1329	T2093	T2069	punct	.,appear
R1330	T2095	T2096	advmod	Thus,define
R1331	T2097	T2096	nsubj	we,define
R1332	T2098	T2099	det	the,peptide
R1333	T2099	T2096	dobj	peptide,define
R1334	T2100	T2101	npadvmod	C,terminal
R1335	T2101	T2099	amod	terminal,peptide
R1336	T2102	T2101	punct	-,terminal
R1337	T2103	T2096	prep	as,define
R1338	T2104	T2103	pcomp	being,as
R1339	T2105	T2106	det	the,acids
R1340	T2106	T2104	attr	acids,being
R1341	T2107	T2106	amod	final,acids
R1342	T2108	T2106	nummod	32,acids
R1343	T2109	T2106	compound	amino,acids
R1344	T2110	T2106	prep	of,acids
R1345	T2111	T2110	pobj	PAX6,of
R1346	T2112	T2106	punct	", ",acids
R1347	T2113	T2106	acl	running,acids
R1348	T2114	T2113	prep	from,running
R1349	T2115	T2114	pobj	threonine,from
R1350	T2116	T2115	nummod	391,threonine
R1351	T2117	T2113	prep	to,running
R1352	T2118	T2119	det	the,codon
R1353	T2119	T2117	pobj	codon,to
R1354	T2120	T2119	compound	stop,codon
R1355	T2121	T2122	punct	(,line
R1356	T2122	T2096	parataxis	line,define
R1357	T2123	T2122	compound	top,line
R1358	T2124	T2122	prep	of,line
R1359	T2125	T2124	pobj	Figure,of
R1360	T2126	T2125	nummod	1c,Figure
R1361	T2127	T2122	punct	),line
R1362	T2128	T2096	punct	.,define
R1365	T2344	T2345	nmod	Yeast,screening
R1366	T2346	T2347	nummod	two,hybrid
R1367	T2347	T2345	compound	hybrid,screening
R1368	T2348	T2347	punct	-,hybrid
R1369	T2350	T2351	nsubj	We,hypothesised
R1370	T2352	T2353	mark	that,involved
R1371	T2353	T2351	ccomp	involved,hypothesised
R1372	T2354	T2355	det	the,peptide
R1373	T2355	T2353	nsubjpass	peptide,involved
R1374	T2356	T2357	npadvmod	C,terminal
R1375	T2357	T2355	amod	terminal,peptide
R1376	T2358	T2357	punct	-,terminal
R1377	T2359	T2353	aux	might,involved
R1378	T2360	T2353	auxpass	be,involved
R1379	T2361	T2353	prep	in,involved
R1380	T2362	T2363	nmod	protein,protein
R1381	T2363	T2365	compound	protein,interactions
R1382	T2364	T2363	punct	-,protein
R1383	T2365	T2361	pobj	interactions,in
R1384	T2366	T2351	punct	", ",hypothesised
R1385	T2367	T2351	cc	and,hypothesised
R1386	T2368	T2369	nsubj	we,tested
R1387	T2369	T2351	conj	tested,hypothesised
R1388	T2370	T2369	dobj	this,tested
R1389	T2371	T2369	prep	by,tested
R1390	T2372	T2371	pcomp	screening,by
R1391	T2373	T2374	det	a,library
R1392	T2374	T2372	dobj	library,screening
R1393	T2375	T2374	compound	cDNA,library
R1394	T2376	T2372	advcl	using,screening
R1395	T2377	T2378	det	the,system
R1396	T2378	T2376	dobj	system,using
R1397	T2379	T2378	nmod	yeast,system
R1398	T2380	T2381	nummod	two,hybrid
R1399	T2381	T2378	compound	hybrid,system
R1400	T2382	T2381	punct	-,hybrid
R1401	T2383	T2378	prep	with,system
R1402	T2384	T2385	det	a,construct
R1403	T2385	T2383	pobj	construct,with
R1404	T2386	T2387	punct	(,PAX6CTP
R1405	T2387	T2385	parataxis	PAX6CTP,construct
R1406	T2388	T2387	punct	),PAX6CTP
R1407	T2389	T2390	prep	in,fused
R1408	T2390	T2385	relcl	fused,construct
R1409	T2391	T2389	pobj	which,in
R1410	T2392	T2393	det	the,peptide
R1411	T2393	T2390	nsubjpass	peptide,fused
R1412	T2394	T2395	nummod	32,acid
R1413	T2395	T2393	nmod	acid,peptide
R1414	T2396	T2395	nmod	amino,acid
R1415	T2397	T2398	npadvmod	C,terminal
R1416	T2398	T2393	amod	terminal,peptide
R1417	T2399	T2398	punct	-,terminal
R1418	T2400	T2390	auxpass	was,fused
R1419	T2401	T2390	prep	to,fused
R1420	T2402	T2403	det	the,domain
R1421	T2403	T2401	pobj	domain,to
R1422	T2404	T2403	compound	yeast,domain
R1423	T2405	T2403	compound	GAL4,domain
R1424	T2406	T2407	compound	DNA,binding
R1425	T2407	T2403	compound	binding,domain
R1426	T2408	T2369	punct	.,tested
R1427	T2410	T2411	nsubj	We,chose
R1428	T2412	T2413	aux	to,screen
R1429	T2413	T2411	xcomp	screen,chose
R1430	T2414	T2415	det	a,library
R1431	T2415	T2413	dobj	library,screen
R1432	T2416	T2417	compound	mouse,brain
R1433	T2417	T2415	compound	brain,library
R1434	T2418	T2415	compound	cDNA,library
R1435	T2419	T2420	mark	as,were
R1436	T2420	T2411	advcl	were,chose
R1437	T2421	T2422	det	no,libraries
R1438	T2422	T2420	nsubj	libraries,were
R1439	T2423	T2422	amod	human,libraries
R1440	T2424	T2420	acomp	available,were
R1441	T2425	T2411	punct	.,chose
R1442	T2427	T2428	prep	Given,reasoned
R1443	T2429	T2430	det	the,fact
R1444	T2430	T2427	pobj	fact,Given
R1445	T2431	T2432	mark	that,is
R1446	T2432	T2430	acl	is,fact
R1447	T2433	T2434	det	the,sequence
R1448	T2434	T2432	nsubj	sequence,is
R1449	T2435	T2436	compound	amino,acid
R1450	T2436	T2434	compound	acid,sequence
R1451	T2437	T2434	prep	of,sequence
R1452	T2438	T2439	det	the,protein
R1453	T2439	T2437	pobj	protein,of
R1454	T2440	T2439	compound	PAX6,protein
R1455	T2441	T2432	acomp	identical,is
R1456	T2442	T2432	prep	in,is
R1457	T2443	T2442	pobj	man,in
R1458	T2444	T2443	cc	and,man
R1459	T2445	T2443	conj	mouse,man
R1460	T2446	T2428	punct	", ",reasoned
R1461	T2447	T2428	nsubj	we,reasoned
R1462	T2448	T2449	mark	that,yield
R1463	T2449	T2428	ccomp	yield,reasoned
R1464	T2450	T2451	det	a,library
R1465	T2451	T2449	nsubj	library,yield
R1466	T2452	T2453	compound	mouse,brain
R1467	T2453	T2451	compound	brain,library
R1468	T2454	T2449	aux	would,yield
R1469	T2455	T2456	amod	relevant,interactors
R1470	T2456	T2449	dobj	interactors,yield
R1471	T2457	T2428	punct	.,reasoned
R1472	T2459	T2460	prep	For,carried
R1473	T2461	T2459	pobj	comparison,For
R1474	T2462	T2460	nsubj	we,carried
R1475	T2463	T2460	advmod	also,carried
R1476	T2464	T2460	prt	out,carried
R1477	T2465	T2466	det	the,screen
R1478	T2466	T2460	dobj	screen,carried
R1479	T2467	T2460	advcl	using,carried
R1480	T2468	T2469	det	a,construct
R1481	T2469	T2467	dobj	construct,using
R1482	T2470	T2469	acl	containing,construct
R1483	T2471	T2472	det	the,domain
R1484	T2472	T2470	dobj	domain,containing
R1485	T2473	T2472	amod	whole,domain
R1486	T2474	T2472	compound	PST,domain
R1487	T2475	T2469	punct	(,construct
R1488	T2476	T2469	appos	PAX6PST,construct
R1489	T2477	T2469	punct	),construct
R1490	T2478	T2460	punct	.,carried
R1491	T2480	T2481	det	The,screen
R1492	T2481	T2486	nsubj	screen,gave
R1493	T2482	T2483	npadvmod	C,terminal
R1494	T2483	T2481	amod	terminal,screen
R1495	T2484	T2483	punct	-,terminal
R1496	T2485	T2481	compound	peptide,screen
R1497	T2487	T2488	nummod	15,colonies
R1498	T2488	T2486	dobj	colonies,gave
R1499	T2489	T2490	dep	that,were
R1500	T2490	T2488	relcl	were,colonies
R1501	T2491	T2490	acomp	positive,were
R1502	T2492	T2491	prep	with,positive
R1503	T2493	T2494	det	all,reporters
R1504	T2494	T2492	pobj	reporters,with
R1505	T2495	T2494	nummod	three,reporters
R1506	T2496	T2486	cc	and,gave
R1507	T2497	T2498	det	the,screen
R1508	T2498	T2501	nsubj	screen,gave
R1509	T2499	T2498	compound	PST,screen
R1510	T2500	T2498	compound	domain,screen
R1511	T2501	T2486	conj	gave,gave
R1512	T2502	T2503	nummod	62,colonies
R1513	T2503	T2501	dobj	colonies,gave
R1514	T2504	T2501	punct	.,gave
R1515	T2506	T2507	det	The,plasmids
R1516	T2507	T2509	nsubjpass	plasmids,isolated
R1517	T2508	T2507	amod	interacting,plasmids
R1518	T2510	T2509	auxpass	were,isolated
R1519	T2511	T2509	cc	and,isolated
R1520	T2512	T2513	det	the,inserts
R1521	T2513	T2515	nsubj	inserts,sequenced
R1522	T2514	T2513	compound	cDNA,inserts
R1523	T2515	T2509	conj	sequenced,isolated
R1524	T2516	T2515	punct	.,sequenced
R1525	T2518	T2519	nummod	Three,cDNAs
R1526	T2519	T2520	nsubjpass	cDNAs,identified
R1527	T2521	T2520	auxpass	were,identified
R1528	T2522	T2523	nummod	3,times
R1529	T2523	T2520	npadvmod	times,identified
R1530	T2524	T2522	cc	or,3
R1531	T2525	T2522	conj	more,3
R1532	T2526	T2520	punct	", ",identified
R1533	T2527	T2520	dep	Homer3,identified
R1534	T2528	T2527	punct	(,Homer3
R1535	T2529	T2527	appos	NM_011984,Homer3
R1536	T2530	T2527	punct	),Homer3
R1537	T2531	T2527	punct	", ",Homer3
R1538	T2532	T2527	conj	Dncl1,Homer3
R1539	T2533	T2532	punct	(,Dncl1
R1540	T2534	T2535	nmod	Dynein,chain
R1541	T2535	T2532	appos	chain,Dncl1
R1542	T2536	T2535	amod	cytoplasmic,chain
R1543	T2537	T2535	amod	light,chain
R1544	T2538	T2535	nummod	1,chain
R1545	T2539	T2535	punct	", ",chain
R1546	T2540	T2535	appos	NM_019682,chain
R1547	T2541	T2535	punct	", ",chain
R1548	T2542	T2543	advmod	also,known
R1549	T2543	T2535	acl	known,chain
R1550	T2544	T2543	prep	as,known
R1551	T2545	T2544	pobj	Pin,as
R1552	T2546	T2545	cc	or,Pin
R1553	T2547	T2545	conj	Dlc8,Pin
R1554	T2548	T2532	punct	),Dncl1
R1555	T2549	T2532	cc	and,Dncl1
R1556	T2550	T2532	conj	Trim11,Dncl1
R1557	T2551	T2550	punct	(,Trim11
R1558	T2552	T2553	amod	Tripartite,motif
R1559	T2553	T2554	compound	motif,member
R1560	T2554	T2550	appos	member,Trim11
R1561	T2555	T2554	compound	protein,member
R1562	T2556	T2554	compound	family,member
R1563	T2557	T2554	nummod	11,member
R1564	T2558	T2554	punct	", ",member
R1565	T2559	T2554	appos	NM_053168,member
R1566	T2560	T2550	punct	),Trim11
R1567	T2561	T2520	punct	.,identified
R1568	T2563	T2564	nsubjpass	Homer3,identified
R1569	T2565	T2566	punct	(,clones
R1570	T2566	T2563	parataxis	clones,Homer3
R1571	T2567	T2566	nummod	6,clones
R1572	T2568	T2566	punct	),clones
R1573	T2569	T2563	cc	and,Homer3
R1574	T2570	T2563	conj	Dncl1,Homer3
R1575	T2571	T2572	punct	(,clones
R1576	T2572	T2570	parataxis	clones,Dncl1
R1577	T2573	T2572	nummod	2,clones
R1578	T2574	T2572	punct	),clones
R1579	T2575	T2564	auxpass	were,identified
R1580	T2576	T2564	prep	in,identified
R1581	T2577	T2578	det	the,screen
R1582	T2578	T2576	pobj	screen,in
R1583	T2579	T2580	npadvmod	C,terminal
R1584	T2580	T2578	amod	terminal,screen
R1585	T2581	T2580	punct	-,terminal
R1586	T2582	T2578	compound	peptide,screen
R1587	T2583	T2564	punct	.,identified
R1588	T2585	T2586	nsubjpass	Homer3,identified
R1589	T2587	T2588	punct	(,clones
R1590	T2588	T2585	parataxis	clones,Homer3
R1591	T2589	T2588	nummod	7,clones
R1592	T2590	T2588	punct	),clones
R1593	T2591	T2585	punct	", ",Homer3
R1594	T2592	T2585	conj	Dncl1,Homer3
R1595	T2593	T2594	punct	(,clones
R1596	T2594	T2592	parataxis	clones,Dncl1
R1597	T2595	T2594	nummod	2,clones
R1598	T2596	T2594	punct	),clones
R1599	T2597	T2592	cc	and,Dncl1
R1600	T2598	T2592	conj	Trim11,Dncl1
R1601	T2599	T2600	punct	(,clones
R1602	T2600	T2598	parataxis	clones,Trim11
R1603	T2601	T2600	nummod	6,clones
R1604	T2602	T2600	punct	),clones
R1605	T2603	T2586	auxpass	were,identified
R1606	T2604	T2586	prep	in,identified
R1607	T2605	T2606	det	the,screen
R1608	T2606	T2604	pobj	screen,in
R1609	T2607	T2606	compound	PST,screen
R1610	T2608	T2606	compound	domain,screen
R1611	T2609	T2586	punct	.,identified
R1612	T2611	T2612	det	All,inserts
R1613	T2612	T2614	nsubj	inserts,were
R1614	T2613	T2612	compound	cDNA,inserts
R1615	T2615	T2614	prep	in,were
R1616	T2616	T2615	punct	-,in
R1617	T2617	T2615	pobj	frame,in
R1618	T2618	T2617	prep	with,frame
R1619	T2619	T2620	det	the,region
R1620	T2620	T2618	pobj	region,with
R1621	T2621	T2620	compound	coding,region
R1622	T2622	T2620	prep	of,region
R1623	T2623	T2624	det	the,domain
R1624	T2624	T2622	pobj	domain,of
R1625	T2625	T2624	compound	pPC86,domain
R1626	T2626	T2624	compound	GAL4,domain
R1627	T2627	T2624	compound	activation,domain
R1628	T2628	T2614	punct	.,were
R1629	T2630	T2631	nsubj	None,was
R1630	T2632	T2630	prep	of,None
R1631	T2633	T2634	det	the,cDNAs
R1632	T2634	T2632	pobj	cDNAs,of
R1633	T2635	T2631	acomp	present,was
R1634	T2636	T2631	prep	in,was
R1635	T2637	T2638	det	a,list
R1636	T2638	T2636	pobj	list,in
R1637	T2639	T2638	prep	of,list
R1638	T2640	T2641	amod	known,positives
R1639	T2641	T2639	pobj	positives,of
R1640	T2642	T2641	amod	false,positives
R1641	T2643	T2644	punct	[,34
R1642	T2644	T2631	parataxis	34,was
R1643	T2645	T2644	punct	],34
R1644	T2646	T2631	punct	.,was
R1645	T2648	T2649	nsubj	HOMER3,is
R1646	T2650	T2651	det	a,member
R1647	T2651	T2649	attr	member,is
R1648	T2652	T2651	prep	of,member
R1649	T2653	T2654	det	the,family
R1650	T2654	T2652	pobj	family,of
R1651	T2655	T2654	compound	HOMER,family
R1652	T2656	T2654	prep	of,family
R1653	T2657	T2658	amod	neuronal,proteins
R1654	T2658	T2656	pobj	proteins,of
R1655	T2659	T2660	amod	post-synaptic,density
R1656	T2660	T2658	nmod	density,proteins
R1657	T2661	T2660	punct	(,density
R1658	T2662	T2660	appos	PSD,density
R1659	T2663	T2658	punct	),proteins
R1660	T2664	T2665	punct	[,35
R1661	T2665	T2649	parataxis	35,is
R1662	T2666	T2665	punct	],35
R1663	T2667	T2649	punct	.,is
R1664	T2669	T2670	nsubj	DNCL1,is
R1665	T2671	T2672	det	a,subunit
R1666	T2672	T2670	attr	subunit,is
R1667	T2673	T2672	prep	of,subunit
R1668	T2674	T2675	nummod	two,complexes
R1669	T2675	T2673	pobj	complexes,of
R1670	T2676	T2675	compound	motor,complexes
R1671	T2677	T2675	compound	protein,complexes
R1672	T2678	T2675	punct	", ",complexes
R1673	T2679	T2675	appos	dynein,complexes
R1674	T2680	T2679	cc	and,dynein
R1675	T2681	T2682	compound	myosin,Va
R1676	T2682	T2679	conj	Va,dynein
R1677	T2683	T2682	punct	-,Va
R1678	T2684	T2679	punct	", ",dynein
R1679	T2685	T2686	dep	both,involved
R1680	T2686	T2679	relcl	involved,dynein
R1681	T2687	T2685	prep	of,both
R1682	T2688	T2687	pobj	which,of
R1683	T2689	T2686	auxpass	are,involved
R1684	T2690	T2686	prep	in,involved
R1685	T2691	T2692	amod	intracellular,trafficking
R1686	T2692	T2690	pobj	trafficking,in
R1687	T2693	T2692	prep	of,trafficking
R1688	T2694	T2693	pobj	proteins,of
R1689	T2695	T2694	cc	and,proteins
R1690	T2696	T2694	conj	organelles,proteins
R1691	T2697	T2686	prep	in,involved
R1692	T2698	T2697	pobj	neurons,in
R1693	T2699	T2700	punct	[,37
R1694	T2700	T2670	parataxis	37,is
R1695	T2701	T2700	nummod	36,37
R1696	T2702	T2700	punct	",",37
R1697	T2703	T2700	punct	],37
R1698	T2704	T2670	punct	.,is
R1699	T2706	T2707	nsubj	TRIM11,is
R1700	T2708	T2709	det	a,member
R1701	T2709	T2707	attr	member,is
R1702	T2710	T2709	prep	of,member
R1703	T2711	T2712	det	the,family
R1704	T2712	T2710	pobj	family,of
R1705	T2713	T2714	amod	tripartite,motif
R1706	T2714	T2712	compound	motif,family
R1707	T2715	T2712	compound	protein,family
R1708	T2716	T2707	cc	and,is
R1709	T2717	T2707	conj	contains,is
R1710	T2718	T2719	det	a,finger
R1711	T2719	T2717	dobj	finger,contains
R1712	T2720	T2719	compound	RING,finger
R1713	T2721	T2719	punct	", ",finger
R1714	T2722	T2723	det	a,finger
R1715	T2723	T2719	conj	finger,finger
R1716	T2724	T2725	compound	B,box
R1717	T2725	T2723	compound	box,finger
R1718	T2726	T2725	punct	-,box
R1719	T2727	T2723	compound	zinc,finger
R1720	T2728	T2723	punct	", ",finger
R1721	T2729	T2730	det	a,domain
R1722	T2730	T2723	conj	domain,finger
R1723	T2731	T2732	amod	coiled,coil
R1724	T2732	T2730	compound	coil,domain
R1725	T2733	T2730	cc	and,domain
R1726	T2734	T2735	det	a,domain
R1727	T2735	T2730	conj	domain,domain
R1728	T2736	T2735	compound	B30.2,domain
R1729	T2737	T2738	punct	[,38
R1730	T2738	T2717	parataxis	38,contains
R1731	T2739	T2738	punct	],38
R1732	T2740	T2707	punct	.,is
R1733	T2742	T2743	det	The,significance
R1734	T2743	T2745	nsubjpass	significance,discussed
R1735	T2744	T2743	amod	possible,significance
R1736	T2746	T2743	prep	of,significance
R1737	T2747	T2748	det	the,interactions
R1738	T2748	T2746	pobj	interactions,of
R1739	T2749	T2748	prep	between,interactions
R1740	T2750	T2751	det	these,proteins
R1741	T2751	T2749	pobj	proteins,between
R1742	T2752	T2751	cc	and,proteins
R1743	T2753	T2751	conj	PAX6,proteins
R1744	T2754	T2745	auxpass	is,discussed
R1745	T2755	T2745	advmod	below,discussed
R1746	T2756	T2745	punct	.,discussed
R1747	T2839	T2840	amod	Semi-quantitative,PCR
R1748	T2842	T2843	aux	To,check
R1749	T2843	T2844	advcl	check,performed
R1750	T2845	T2846	mark	that,identified
R1751	T2846	T2843	ccomp	identified,check
R1752	T2847	T2848	det	the,clones
R1753	T2848	T2846	nsubjpass	clones,identified
R1754	T2849	T2848	nmod	Homer3,clones
R1755	T2850	T2849	punct	", ",Homer3
R1756	T2851	T2849	conj	Dncl1,Homer3
R1757	T2852	T2851	cc	and,Dncl1
R1758	T2853	T2851	conj	Trim11,Dncl1
R1759	T2854	T2846	auxpass	were,identified
R1760	T2855	T2846	neg	not,identified
R1761	T2856	T2857	amod	multiple,times
R1762	T2857	T2846	npadvmod	times,identified
R1763	T2858	T2859	advmod	solely,are
R1764	T2859	T2846	advcl	are,identified
R1765	T2860	T2859	mark	because,are
R1766	T2861	T2859	nsubj	they,are
R1767	T2862	T2863	advmod	highly,abundant
R1768	T2863	T2859	acomp	abundant,are
R1769	T2864	T2859	prep	in,are
R1770	T2865	T2866	det	the,library
R1771	T2866	T2864	pobj	library,in
R1772	T2867	T2844	punct	", ",performed
R1773	T2868	T2844	nsubj	we,performed
R1774	T2869	T2870	det	a,assay
R1775	T2870	T2844	dobj	assay,performed
R1776	T2871	T2870	amod	semi-quantitative,assay
R1777	T2872	T2870	compound	PCR,assay
R1778	T2873	T2844	punct	.,performed
R1779	T2875	T2876	nsubj	We,compared
R1780	T2877	T2878	det	the,abundance
R1781	T2878	T2876	dobj	abundance,compared
R1782	T2879	T2878	amod	relative,abundance
R1783	T2880	T2878	prep	of,abundance
R1784	T2881	T2880	pobj	Homer3,of
R1785	T2882	T2881	punct	", ",Homer3
R1786	T2883	T2881	conj	Dncl1,Homer3
R1787	T2884	T2883	punct	", ",Dncl1
R1788	T2885	T2883	conj	Trim11,Dncl1
R1789	T2886	T2885	cc	and,Trim11
R1790	T2887	T2885	conj	Pax6,Trim11
R1791	T2888	T2876	prep	with,compared
R1792	T2889	T2888	pobj	Gapdh,with
R1793	T2890	T2889	cc	and,Gapdh
R1794	T2891	T2889	conj	Atp5a1,Gapdh
R1795	T2892	T2876	punct	.,compared
R1796	T2894	T2895	nsubj	Gapdh,show
R1797	T2896	T2894	cc	and,Gapdh
R1798	T2897	T2894	conj	Atp5a1,Gapdh
R1799	T2898	T2894	appos	both,Gapdh
R1800	T2899	T2900	amod	strong,expression
R1801	T2900	T2895	dobj	expression,show
R1802	T2901	T2900	amod	constitutive,expression
R1803	T2902	T2895	prep	in,show
R1804	T2903	T2904	det	a,variety
R1805	T2904	T2902	pobj	variety,in
R1806	T2905	T2904	prep	of,variety
R1807	T2906	T2905	pobj	tissues,of
R1808	T2907	T2906	prep	including,tissues
R1809	T2908	T2909	det	the,brain
R1810	T2909	T2907	pobj	brain,including
R1811	T2910	T2911	punct	[,30
R1812	T2911	T2895	parataxis	30,show
R1813	T2912	T2911	nummod	29,30
R1814	T2913	T2911	punct	",",30
R1844	T2945	T2938	prep	compared,were
R1845	T2946	T2945	prep	to,compared
R1846	T2947	T2946	pobj	Gapdh,to
R1847	T2948	T2947	punct	(,Gapdh
R1848	T2949	T2947	acl	amplified,Gapdh
R1849	T2950	T2949	advmod	strongly,amplified
R1850	T2951	T2949	prep	after,amplified
R1851	T2952	T2953	nummod	25,cycles
R1852	T2953	T2951	pobj	cycles,after
R1853	T2954	T2947	punct	),Gapdh
R1854	T2955	T2947	cc	and,Gapdh
R1855	T2956	T2947	conj	Atp5a1,Gapdh
R1856	T2957	T2956	punct	(,Atp5a1
R1857	T2958	T2956	acl	amplified,Atp5a1
R1858	T2959	T2958	advmod	strongly,amplified
R1859	T2960	T2958	prep	after,amplified
R1860	T2961	T2962	nummod	30,cycles
R1861	T2962	T2960	pobj	cycles,after
R1862	T2963	T2964	punct	;,Figure
R1863	T2964	T2938	parataxis	Figure,were
R1864	T2965	T2964	nummod	2,Figure
R1865	T2966	T2964	punct	),Figure
R1866	T2967	T2918	punct	.,amplified
R1869	T2972	T2970	ccomp	were,concluded
R1871	T2974	T2972	nsubj	clones,were
R1873	T2976	T2973	conj	Dncl1,Homer3
R1874	T2977	T2976	cc	and,Dncl1
R1875	T2978	T2976	conj	Trim11,Dncl1
R1876	T2979	T2972	neg	not,were
R1877	T2980	T2981	advmod	highly,abundant
R1878	T2981	T2972	acomp	abundant,were
R1879	T2982	T2972	prep	in,were
R1880	T2983	T2984	det	the,library
R1881	T2984	T2982	pobj	library,in
R1882	T2985	T2970	punct	.,concluded
R1883	T2987	T2988	nsubj	This,is
R1884	T2989	T2988	acomp	consistent,is
R1885	T2990	T2989	prep	with,consistent
R1886	T2991	T2992	det	the,idea
R1887	T2992	T2990	pobj	idea,with
R1888	T2993	T2994	mark	that,pulled
R1889	T2994	T2992	acl	pulled,idea
R1890	T2995	T2994	nsubjpass	they,pulled
R1891	T2996	T2994	auxpass	were,pulled
R1892	T2997	T2994	prt	out,pulled
R1893	T2998	T2999	mark	because,interact
R1894	T2999	T2994	advcl	interact,pulled
R1895	T3000	T3001	det	the,proteins
R1896	T3001	T2999	nsubj	proteins,interact
R1897	T3002	T3001	amod	encoded,proteins
R1898	T3003	T2999	advmod	specifically,interact
R1899	T3004	T2999	prep	with,interact
R1900	T3005	T3006	det	the,peptide
R1901	T3006	T3004	pobj	peptide,with
R1902	T3007	T3008	npadvmod	C,terminal
R1903	T3008	T3006	amod	terminal,peptide
R1904	T3009	T3008	punct	-,terminal
R1905	T3010	T3006	cc	or,peptide
R1906	T3011	T3012	compound	PST,domain
R1907	T3012	T3006	conj	domain,peptide
R1908	T3013	T3012	prep	of,domain
R1909	T3014	T3013	pobj	PAX6,of
R1910	T3015	T2988	punct	.,is
R1911	T3382	T3383	nmod	Yeast,interactions
R1912	T3384	T3385	nummod	two,hybrid
R1913	T3385	T3383	nmod	hybrid,interactions
R1914	T3386	T3385	punct	-,hybrid
R1915	T3387	T3383	amod	pairwise,interactions
R1916	T3389	T3390	prep	By,identified
R1917	T3391	T3392	compound	library,screening
R1918	T3392	T3389	pobj	screening,By
R1919	T3393	T3390	nsubj	we,identified
R1920	T3394	T3395	nummod	two,proteins
R1921	T3395	T3390	dobj	proteins,identified
R1922	T3396	T3395	punct	(,proteins
R1923	T3397	T3395	appos	HOMER3,proteins
R1924	T3398	T3397	cc	and,HOMER3
R1925	T3399	T3397	conj	DNCL1,HOMER3
R1926	T3400	T3395	punct	),proteins
R1927	T3401	T3402	dep	that,interact
R1928	T3402	T3395	relcl	interact,proteins
R1929	T3403	T3402	prep	with,interact
R1930	T3404	T3405	det	the,peptide
R1931	T3405	T3403	pobj	peptide,with
R1932	T3406	T3407	npadvmod	C,terminal
R1933	T3407	T3405	amod	terminal,peptide
R1934	T3408	T3407	punct	-,terminal
R1935	T3409	T3405	cc	and,peptide
R1936	T3410	T3411	nummod	three,proteins
R1937	T3411	T3405	conj	proteins,peptide
R1938	T3412	T3411	punct	(,proteins
R1939	T3413	T3411	appos	HOMER3,proteins
R1940	T3414	T3413	punct	", ",HOMER3
R1941	T3415	T3413	conj	DNCL1,HOMER3
R1942	T3416	T3415	cc	and,DNCL1
R1943	T3417	T3415	conj	TRIM11,DNCL1
R1944	T3418	T3411	punct	),proteins
R1945	T3419	T3420	dep	that,interact
R1946	T3420	T3411	relcl	interact,proteins
R1947	T3421	T3420	prep	with,interact
R1948	T3422	T3423	det	the,domain
R1949	T3423	T3421	pobj	domain,with
R1950	T3424	T3423	amod	whole,domain
R1951	T3425	T3423	compound	PST,domain
R1952	T3426	T3390	punct	.,identified
R1953	T3428	T3429	nsubj	This,suggests
R1954	T3430	T3431	mark	that,interact
R1955	T3431	T3429	ccomp	interact,suggests
R1956	T3432	T3431	nsubj	HOMER3,interact
R1957	T3433	T3432	cc	and,HOMER3
R1958	T3434	T3432	conj	DNCL1,HOMER3
R1959	T3435	T3436	advmod	specifically,with
R1960	T3436	T3431	prep	with,interact
R1961	T3437	T3438	det	the,peptide
R1962	T3438	T3436	pobj	peptide,with
R1963	T3439	T3440	npadvmod	C,terminal
R1964	T3440	T3438	amod	terminal,peptide
R1965	T3441	T3440	punct	-,terminal
R1966	T3442	T3443	mark	while,interacts
R1967	T3443	T3431	advcl	interacts,interact
R1968	T3444	T3443	nsubj	TRIM11,interacts
R1969	T3445	T3443	prep	with,interacts
R1970	T3446	T3447	det	a,part
R1971	T3447	T3445	pobj	part,with
R1972	T3448	T3449	advmod	more,terminal
R1973	T3449	T3447	amod	terminal,part
R1974	T3450	T3449	npadvmod	N,terminal
R1975	T3451	T3449	punct	-,terminal
R1976	T3452	T3447	prep	of,part
R1977	T3453	T3454	det	the,domain
R1978	T3454	T3452	pobj	domain,of
R1979	T3455	T3454	compound	PST,domain
R1980	T3456	T3429	punct	.,suggests
R1981	T3458	T3459	nsubj	We,conducted
R1982	T3460	T3461	amod	pairwise,tests
R1983	T3461	T3459	dobj	tests,conducted
R1984	T3462	T3461	prep	between,tests
R1985	T3463	T3464	amod	specific,constructs
R1986	T3464	T3462	pobj	constructs,between
R1987	T3465	T3466	aux	to,confirm
R1988	T3466	T3459	advcl	confirm,conducted
R1989	T3467	T3468	det	the,interactions
R1990	T3468	T3466	dobj	interactions,confirm
R1991	T3469	T3468	acl	identified,interactions
R1992	T3470	T3469	prep	in,identified
R1993	T3471	T3472	det	the,screen
R1994	T3472	T3470	pobj	screen,in
R1995	T3473	T3472	compound	library,screen
R1996	T3474	T3466	cc	and,confirm
R1997	T3475	T3476	aux	to,investigate
R1998	T3476	T3466	conj	investigate,confirm
R1999	T3477	T3476	advmod	further,investigate
R2000	T3478	T3479	det	the,interaction
R2001	T3479	T3476	dobj	interaction,investigate
R2002	T3480	T3479	prep	between,interaction
R2003	T3481	T3480	pobj	PAX6,between
R2004	T3482	T3481	cc	and,PAX6
R2005	T3483	T3481	conj	HOMER3,PAX6
R2006	T3484	T3481	punct	", ",PAX6
R2007	T3485	T3481	appos	DNCL1,PAX6
R2008	T3486	T3485	cc	and,DNCL1
R2009	T3487	T3485	conj	TRIM11,DNCL1
R2010	T3488	T3459	punct	.,conducted
R2011	T3490	T3491	det	The,clones
R2012	T3491	T3495	nsubj	clones,were
R2013	T3492	T3491	nmod	Dncl1,clones
R2014	T3493	T3492	cc	and,Dncl1
R2015	T3494	T3492	conj	Trim11,Dncl1
R2016	T3496	T3497	dep	that,pulled
R2017	T3497	T3491	relcl	pulled,clones
R2018	T3498	T3497	auxpass	were,pulled
R2019	T3499	T3497	prep	out,pulled
R2020	T3500	T3499	prep	of,out
R2021	T3501	T3502	det	the,library
R2022	T3502	T3500	pobj	library,of
R2023	T3503	T3504	amod	full,length
R2024	T3504	T3495	attr	length,were
R2025	T3505	T3504	punct	-,length
R2026	T3506	T3495	punct	", ",were
R2027	T3507	T3495	cc	but,were
R2028	T3508	T3509	det	the,cDNAs
R2029	T3509	T3511	nsubj	cDNAs,lacked
R2030	T3510	T3509	compound	Homer3,cDNAs
R2031	T3511	T3495	conj	lacked,were
R2032	T3512	T3513	det	the,acids
R2033	T3513	T3511	dobj	acids,lacked
R2034	T3514	T3515	npadvmod	N,terminal
R2035	T3515	T3513	amod	terminal,acids
R2036	T3516	T3515	punct	-,terminal
R2037	T3517	T3513	nummod	70,acids
R2038	T3518	T3513	compound	amino,acids
R2039	T3519	T3511	punct	.,lacked
R2040	T3521	T3522	det	The,region
R2041	T3522	T3525	nsubjpass	region,inserted
R2042	T3523	T3522	amod	missing,region
R2043	T3524	T3522	compound	coding,region
R2044	T3526	T3525	auxpass	was,inserted
R2045	T3527	T3525	prep	into,inserted
R2046	T3528	T3529	det	the,cDNA
R2047	T3529	T3527	pobj	cDNA,into
R2048	T3530	T3529	amod	truncated,cDNA
R2049	T3531	T3529	compound	Homer3,cDNA
R2050	T3532	T3533	aux	to,give
R2051	T3533	T3525	advcl	give,inserted
R2052	T3534	T3535	det	a,construct
R2053	T3535	T3533	dobj	construct,give
R2054	T3536	T3537	amod	full,length
R2055	T3537	T3535	compound	length,construct
R2056	T3538	T3537	punct	-,length
R2057	T3539	T3535	compound	expression,construct
R2058	T3540	T3541	punct	(,see
R2059	T3541	T3525	parataxis	see,inserted
R2060	T3542	T3541	dobj	Methods,see
R2061	T3543	T3541	punct	),see
R2062	T3544	T3525	punct	.,inserted
R2063	T3546	T3547	amod	Pairwise,interactions
R2064	T3547	T3548	nsubjpass	interactions,carried
R2065	T3549	T3548	auxpass	were,carried
R2066	T3550	T3548	prt	out,carried
R2067	T3551	T3548	prep	with,carried
R2068	T3552	T3553	preconj	both,clones
R2069	T3553	T3551	pobj	clones,with
R2070	T3554	T3553	det	the,clones
R2071	T3555	T3556	amod	full,length
R2072	T3556	T3553	nmod	length,clones
R2073	T3557	T3556	punct	-,length
R2074	T3558	T3556	cc	and,length
R2075	T3559	T3556	conj	truncated,length
R2076	T3560	T3553	compound	Homer3,clones
R2077	T3561	T3548	punct	.,carried
R2078	T3563	T3564	nsubj	We,confirmed
R2079	T3565	T3566	mark	that,interacts
R2080	T3566	T3564	ccomp	interacts,confirmed
R2081	T3567	T3568	det	the,domain
R2082	T3568	T3566	nsubj	domain,interacts
R2083	T3569	T3568	amod	whole,domain
R2084	T3570	T3571	compound	PAX6,PST
R2085	T3571	T3568	compound	PST,domain
R2086	T3572	T3566	prep	with,interacts
R2087	T3573	T3572	pobj	HOMER3,with
R2088	T3574	T3575	punct	(,constructs
R2089	T3575	T3573	parataxis	constructs,HOMER3
R2090	T3576	T3577	amod	full,length
R2091	T3577	T3575	nmod	length,constructs
R2092	T3578	T3577	punct	-,length
R2093	T3579	T3577	cc	and,length
R2094	T3580	T3577	conj	truncated,length
R2095	T3581	T3575	punct	),constructs
R2096	T3582	T3573	punct	", ",HOMER3
R2097	T3583	T3573	conj	TRIM11,HOMER3
R2098	T3584	T3583	cc	and,TRIM11
R2099	T3585	T3583	conj	DNCL1,TRIM11
R2100	T3586	T3566	punct	", ",interacts
R2101	T3587	T3588	mark	as,activated
R2102	T3588	T3566	advcl	activated,interacts
R2103	T3589	T3590	det	all,genes
R2104	T3590	T3588	nsubjpass	genes,activated
R2105	T3591	T3590	nummod	three,genes
R2106	T3592	T3590	compound	reporter,genes
R2107	T3593	T3588	auxpass	were,activated
R2108	T3594	T3588	advmod	strongly,activated
R2109	T3595	T3588	prep	in,activated
R2110	T3596	T3597	amod	pairwise,tests
R2111	T3597	T3595	pobj	tests,in
R2112	T3598	T3599	punct	(,Table
R2113	T3599	T3564	parataxis	Table,confirmed
R2114	T3600	T3599	dep	Figure,Table
R2115	T3601	T3600	nummod	3,Figure
R2116	T3602	T3599	punct	;,Table
R2117	T3603	T3599	nummod	1,Table
R2118	T3604	T3599	punct	),Table
R2119	T3605	T3564	punct	.,confirmed
R2120	T3607	T3608	prep	In,confirmed
R2121	T3609	T3607	pobj	contrast,In
R2122	T3610	T3611	det	the,interaction
R2123	T3611	T3608	nsubjpass	interaction,confirmed
R2124	T3612	T3611	prep	between,interaction
R2125	T3613	T3614	det	the,peptide
R2126	T3614	T3612	pobj	peptide,between
R2127	T3615	T3616	npadvmod	C,terminal
R2128	T3616	T3614	amod	terminal,peptide
R2129	T3617	T3616	punct	-,terminal
R2130	T3618	T3614	cc	and,peptide
R2131	T3619	T3614	conj	HOMER3,peptide
R2132	T3620	T3619	cc	or,HOMER3
R2133	T3621	T3619	conj	DNCL1,HOMER3
R2134	T3622	T3608	aux	could,confirmed
R2135	T3623	T3608	neg	not,confirmed
R2136	T3624	T3608	auxpass	be,confirmed
R2137	T3625	T3608	prep	with,confirmed
R2138	T3626	T3627	amod	pairwise,tests
R2139	T3627	T3625	pobj	tests,with
R2140	T3628	T3629	punct	(,Table
R2141	T3629	T3608	parataxis	Table,confirmed
R2142	T3630	T3629	nummod	1,Table
R2143	T3631	T3629	punct	),Table
R2144	T3632	T3608	punct	.,confirmed
R2145	T3634	T3635	advmod	Occasionally,observed
R2146	T3635	T3651	ccomp	observed,observed
R2147	T3636	T3635	punct	", ",observed
R2148	T3637	T3638	amod	partial,suppression
R2149	T3638	T3635	nsubjpass	suppression,observed
R2150	T3639	T3638	prep	of,suppression
R2151	T3640	T3639	pobj	growth,of
R2152	T3641	T3638	prep	on,suppression
R2153	T3642	T3641	pobj	plates,on
R2154	T3643	T3642	acl	containing,plates
R2155	T3644	T3645	advmod	5,orotic
R2156	T3645	T3649	amod	orotic,acid
R2157	T3646	T3645	punct	-,orotic
R2158	T3647	T3645	amod	fluoro,orotic
R2159	T3648	T3645	punct	-,orotic
R2160	T3649	T3643	dobj	acid,containing
R2161	T3650	T3635	auxpass	was,observed
R2162	T3652	T3635	punct	", ",observed
R2163	T3653	T3635	advcl	indicating,observed
R2164	T3654	T3655	amod	low,level
R2165	T3655	T3657	compound	level,activation
R2166	T3656	T3655	punct	-,level
R2167	T3657	T3653	dobj	activation,indicating
R2168	T3658	T3657	prep	of,activation
R2169	T3659	T3660	det	the,reporter
R2170	T3660	T3658	pobj	reporter,of
R2171	T3661	T3660	compound	URA3,reporter
R2172	T3662	T3651	punct	;,observed
R2173	T3663	T3651	advmod	however,observed
R2174	T3664	T3665	nmod	HIS3,activation
R2175	T3665	T3651	nsubjpass	activation,observed
R2176	T3666	T3664	cc	and,HIS3
R2177	T3667	T3664	conj	LacZ,HIS3
R2178	T3668	T3651	auxpass	were,observed
R2179	T3669	T3651	neg	not,observed
R2180	T3670	T3651	punct	.,observed
R2181	T3672	T3673	det	The,reasons
R2182	T3673	T3674	nsubj	reasons,are
R2183	T3675	T3673	prep	for,reasons
R2184	T3676	T3675	pobj	this,for
R2185	T3677	T3674	neg	not,are
R2186	T3678	T3674	acomp	clear,are
R2187	T3679	T3674	punct	", ",are
R2188	T3680	T3681	mark	although,be
R2189	T3681	T3674	advcl	be,are
R2190	T3682	T3681	nsubj	it,be
R2191	T3683	T3681	aux	may,be
R2192	T3684	T3685	mark	that,were
R2193	T3685	T3681	ccomp	were,be
R2194	T3686	T3687	det	the,tests
R2195	T3687	T3685	nsubj	tests,were
R2196	T3688	T3687	amod	pairwise,tests
R2197	T3689	T3685	prep	of,were
R2198	T3690	T3691	amod	sub-optimal,sensitivity
R2199	T3691	T3689	pobj	sensitivity,of
R2200	T3692	T3685	prep	compared,were
R2201	T3693	T3692	prep	to,compared
R2202	T3694	T3695	det	the,screen
R2203	T3695	T3693	pobj	screen,to
R2204	T3696	T3695	compound	library,screen
R2205	T3697	T3674	punct	.,are
R2206	T3699	T3700	advmod	However,were
R2207	T3701	T3700	nsubj	we,were
R2208	T3702	T3700	acomp	able,were
R2209	T3703	T3704	aux	to,confirm
R2210	T3704	T3702	xcomp	confirm,able
R2211	T3705	T3706	mark	that,is
R2212	T3706	T3704	ccomp	is,confirm
R2213	T3707	T3708	det	the,peptide
R2214	T3708	T3706	nsubj	peptide,is
R2215	T3709	T3710	npadvmod	C,terminal
R2216	T3710	T3708	amod	terminal,peptide
R2217	T3711	T3710	punct	-,terminal
R2218	T3712	T3706	acomp	important,is
R2219	T3713	T3712	prep	for,important
R2220	T3714	T3715	det	the,interaction
R2221	T3715	T3713	pobj	interaction,for
R2222	T3716	T3715	prep	with,interaction
R2223	T3717	T3716	pobj	HOMER3,with
R2224	T3718	T3717	cc	and,HOMER3
R2225	T3719	T3717	conj	DNCL1,HOMER3
R2226	T3720	T3721	mark	because,abolished
R2227	T3721	T3706	advcl	abolished,is
R2228	T3722	T3721	nsubjpass	interaction,abolished
R2229	T3723	T3722	prep	with,interaction
R2230	T3724	T3725	det	the,construct
R2231	T3725	T3723	pobj	construct,with
R2232	T3726	T3727	compound	PAX6PST,CT
R2233	T3727	T3725	compound	CT,construct
R2234	T3728	T3727	punct	-,CT
R2235	T3729	T3725	punct	", ",construct
R2236	T3730	T3731	dep	which,lacks
R2237	T3731	T3725	relcl	lacks,construct
R2238	T3732	T3733	det	the,acids
R2239	T3733	T3731	dobj	acids,lacks
R2240	T3734	T3733	amod	final,acids
R2241	T3735	T3733	nummod	32,acids
R2242	T3736	T3733	compound	amino,acids
R2243	T3737	T3721	punct	", ",abolished
R2244	T3738	T3721	auxpass	was,abolished
R2245	T3739	T3721	advmod	completely,abolished
R2246	T3740	T3741	punct	(,Table
R2247	T3741	T3700	parataxis	Table,were
R2248	T3742	T3741	dep	Figure,Table
R2249	T3743	T3742	nummod	3,Figure
R2250	T3744	T3741	punct	", ",Table
R2251	T3745	T3741	nummod	1,Table
R2252	T3746	T3741	punct	),Table
R2253	T3747	T3700	punct	.,were
R2254	T3749	T3750	nsubj	TRIM11,interacted
R2255	T3751	T3752	advmod	equally,well
R2256	T3752	T3750	advmod	well,interacted
R2257	T3753	T3750	prep	with,interacted
R2258	T3754	T3753	pobj	PAX6PST,with
R2259	T3755	T3754	cc	and,PAX6PST
R2260	T3756	T3757	compound	PAX6PST,CT
R2261	T3757	T3754	conj	CT,PAX6PST
R2262	T3758	T3757	punct	-,CT
R2263	T3759	T3760	punct	(,Table
R2264	T3760	T3750	parataxis	Table,interacted
R2265	T3761	T3760	dep	Figure,Table
R2266	T3762	T3761	nummod	3,Figure
R2267	T3763	T3760	punct	", ",Table
R2268	T3764	T3760	nummod	1,Table
R2269	T3765	T3760	punct	),Table
R2270	T3766	T3750	punct	.,interacted
R2271	T3768	T3769	nsubj	This,is
R2272	T3770	T3769	acomp	consistent,is
R2273	T3771	T3770	prep	with,consistent
R2274	T3772	T3773	det	the,screens
R2275	T3773	T3771	pobj	screens,with
R2276	T3774	T3773	compound	library,screens
R2277	T3775	T3776	prep	in,isolated
R2278	T3776	T3773	relcl	isolated,screens
R2279	T3777	T3775	pobj	which,in
R2280	T3778	T3776	nsubjpass	TRIM11,isolated
R2281	T3779	T3776	auxpass	was,isolated
R2282	T3780	T3776	prep	with,isolated
R2283	T3781	T3782	det	the,domain
R2284	T3782	T3780	pobj	domain,with
R2285	T3783	T3782	compound	PST,domain
R2286	T3784	T3780	cc	but,with
R2287	T3785	T3784	neg	not,but
R2288	T3786	T3780	conj	with,with
R2289	T3787	T3788	det	the,peptide
R2290	T3788	T3786	pobj	peptide,with
R2291	T3789	T3790	npadvmod	C,terminal
R2292	T3790	T3788	amod	terminal,peptide
R2293	T3791	T3790	punct	-,terminal
R2294	T3792	T3769	cc	and,is
R2295	T3793	T3769	conj	supports,is
R2296	T3794	T3795	det	the,idea
R2297	T3795	T3793	dobj	idea,supports
R2298	T3796	T3797	mark	that,is
R2299	T3797	T3795	acl	is,idea
R2300	T3798	T3799	det	the,peptide
R2301	T3799	T3797	nsubj	peptide,is
R2302	T3800	T3801	npadvmod	C,terminal
R2303	T3801	T3799	amod	terminal,peptide
R2304	T3802	T3801	punct	-,terminal
R2305	T3803	T3797	neg	not,is
R2306	T3804	T3797	acomp	important,is
R2307	T3805	T3804	prep	for,important
R2308	T3806	T3807	det	the,interaction
R2309	T3807	T3805	pobj	interaction,for
R2310	T3808	T3807	prep	between,interaction
R2311	T3809	T3808	pobj	PAX6,between
R2312	T3810	T3809	cc	and,PAX6
R2313	T3811	T3809	conj	TRIM11,PAX6
R2334	T3848	T3849	det	the,interactions
R2335	T3849	T3847	nsubjpass	interactions,affected
R2336	T3850	T3847	auxpass	were,affected
R2337	T3851	T3847	agent	by,affected
R2338	T3852	T3853	nummod	three,mutations
R2339	T3853	T3851	pobj	mutations,by
R2340	T3854	T3855	npadvmod	C,terminal
R2341	T3855	T3853	amod	terminal,mutations
R2342	T3856	T3855	punct	-,terminal
R2343	T3857	T3853	compound	PAX6,mutations
R2344	T3858	T3859	dep	that,described
R2345	T3859	T3853	relcl	described,mutations
R2346	T3860	T3859	aux	have,described
R2347	T3861	T3859	auxpass	been,described
R2348	T3862	T3859	advmod	previously,described
R2349	T3863	T3859	prep	in,described
R2350	T3864	T3863	pobj	patients,in
R2351	T3865	T3864	prep	with,patients
R2352	T3866	T3867	amod	ocular,anomalies
R2353	T3867	T3865	pobj	anomalies,with
R2354	T3868	T3830	punct	.,investigated
R2355	T3870	T3871	det	The,mutation
R2356	T3871	T3873	nsubj	mutation,is
R2357	T3872	T3871	amod	first,mutation
R2358	T3874	T3875	det	a,substitution
R2359	T3875	T3873	attr	substitution,is
R2360	T3876	T3875	amod	single,substitution
R2361	T3877	T3875	compound	nucleotide,substitution
R2362	T3878	T3875	appos	1627A,substitution
R2363	T3879	T3880	punct	>,G
R2364	T3880	T3878	prep	G,1627A
R2365	T3881	T3882	dep	that,causes
R2366	T3882	T3875	relcl	causes,substitution
R2367	T3883	T3884	det	a,substitution
R2368	T3884	T3882	dobj	substitution,causes
R2369	T3885	T3884	nmod	glutamine,substitution
R2370	T3886	T3885	prep	to,glutamine
R2371	T3887	T3886	pobj	arginine,to
R2372	T3888	T3889	compound	amino,acid
R2373	T3889	T3884	compound	acid,substitution
R2374	T3890	T3882	prep	in,causes
R2375	T3891	T3892	det	the,codon
R2376	T3892	T3890	pobj	codon,in
R2377	T3893	T3892	amod	last,codon
R2378	T3894	T3892	prep	of,codon
R2379	T3895	T3894	pobj	PAX6,of
R2380	T3896	T3873	punct	.,is
R2381	T3898	T3899	det	This,mutation
R2382	T3899	T3901	nsubjpass	mutation,reported
R2383	T3900	T3899	amod	missense,mutation
R2384	T3902	T3899	punct	(,mutation
R2385	T3903	T3899	appos	Q422R,mutation
R2386	T3904	T3899	punct	),mutation
R2387	T3905	T3901	aux	has,reported
R2388	T3906	T3901	auxpass	been,reported
R2389	T3907	T3901	prep	in,reported
R2390	T3908	T3909	nummod	two,patients
R2391	T3909	T3907	pobj	patients,in
R2392	T3910	T3909	punct	", ",patients
R2393	T3911	T3909	appos	one,patients
R2394	T3912	T3911	acl	affected,one
R2395	T3913	T3912	agent	by,affected
R2396	T3914	T3915	amod	anterior,dysgenesis
R2397	T3915	T3913	pobj	dysgenesis,by
R2398	T3916	T3915	compound	segment,dysgenesis
R2399	T3917	T3915	prep	with,dysgenesis
R2400	T3918	T3919	amod	uveal,ectropion
R2401	T3919	T3917	pobj	ectropion,with
R2402	T3920	T3911	cc	and,one
R2403	T3921	T3911	conj	one,one
R2404	T3922	T3921	prep	with,one
R2405	T3923	T3924	amod	typical,aniridia
R2406	T3924	T3922	pobj	aniridia,with
R2407	T3925	T3924	cc	and,aniridia
R2408	T3926	T3927	amod	foveal,hypoplasia
R2409	T3927	T3924	conj	hypoplasia,aniridia
R2410	T3928	T3929	punct	[,33
R2411	T3929	T3901	parataxis	33,reported
R2412	T3930	T3929	nummod	27,33
R2413	T3931	T3929	punct	",",33
R2414	T3932	T3929	punct	],33
R2415	T3933	T3901	punct	.,reported
R2416	T3935	T3936	det	The,mutation
R2417	T3936	T3938	nsubjpass	mutation,found
R2418	T3937	T3936	amod	second,mutation
R2419	T3939	T3936	punct	(,mutation
R2420	T3940	T3936	appos	1615del10,mutation
R2421	T3941	T3936	punct	),mutation
R2422	T3942	T3938	auxpass	was,found
R2423	T3943	T3938	prep	in,found
R2424	T3944	T3945	det	an,family
R2425	T3945	T3943	pobj	family,in
R2426	T3946	T3945	compound	aniridia,family
R2427	T3947	T3948	punct	[,28
R2428	T3948	T3938	parataxis	28,found
R2429	T3949	T3948	punct	],28
R2430	T3950	T3938	punct	.,found
R2431	T3952	T3953	det	This,deletion
R2432	T3953	T3957	nsubj	deletion,occurs
R2433	T3954	T3955	npadvmod	frame,shifting
R2434	T3955	T3953	amod	shifting,deletion
R2435	T3956	T3955	punct	-,shifting
R2436	T3958	T3959	advmod	just,before
R2437	T3959	T3957	prep	before,occurs
R2438	T3960	T3961	det	the,codon
R2439	T3961	T3959	pobj	codon,before
R2440	T3962	T3961	compound	PAX6,codon
R2441	T3963	T3961	compound	stop,codon
R2442	T3964	T3957	cc	and,occurs
R2443	T3965	T3966	auxpass	is,predicted
R2444	T3966	T3957	conj	predicted,occurs
R2445	T3967	T3968	aux	to,cause
R2446	T3968	T3966	xcomp	cause,predicted
R2447	T3969	T3970	amod	translational,through
R2448	T3970	T3968	dobj	through,cause
R2449	T3971	T3970	compound	read,through
R2450	T3972	T3970	punct	-,through
R2451	T3973	T3970	prep	into,through
R2452	T3974	T3975	det	the,region
R2453	T3975	T3973	pobj	region,into
R2454	T3976	T3975	nummod	3,region
R2455	T3977	T3976	punct	',3
R2456	T3978	T3975	amod	untranslated,region
R2457	T3979	T3968	punct	", ",cause
R2458	T3980	T3968	advcl	generating,cause
R2459	T3981	T3982	det	a,protein
R2460	T3982	T3980	dobj	protein,generating
R2461	T3983	T3984	prep	in,replaced
R2462	T3984	T3982	relcl	replaced,protein
R2463	T3985	T3983	pobj	which,in
R2464	T3986	T3987	det	the,acids
R2465	T3987	T3984	nsubjpass	acids,replaced
R2466	T3988	T3987	amod	last,acids
R2467	T3989	T3987	nummod	5,acids
R2468	T3990	T3987	compound	amino,acids
R2469	T3991	T3987	prep	of,acids
R2470	T3992	T3993	det	the,peptide
R2471	T3993	T3991	pobj	peptide,of
R2472	T3994	T3995	npadvmod	C,terminal
R2473	T3995	T3993	amod	terminal,peptide
R2474	T3996	T3995	punct	-,terminal
R2475	T3997	T3984	auxpass	are,replaced
R2476	T3998	T3984	agent	by,replaced
R2477	T3999	T4000	det	a,extension
R2478	T4000	T3998	pobj	extension,by
R2479	T4001	T4002	nummod	103,acid
R2480	T4002	T4000	compound	acid,extension
R2481	T4003	T4002	compound	amino,acid
R2482	T4004	T4000	punct	-,extension
R2483	T4005	T3957	punct	.,occurs
R2484	T4007	T4008	amod	Affected,individuals
R2485	T4008	T4009	nsubj	individuals,showed
R2486	T4010	T4008	prep	in,individuals
R2487	T4011	T4012	det	this,family
R2488	T4012	T4010	pobj	family,in
R2489	T4013	T4014	amod	unusual,traits
R2490	T4014	T4009	dobj	traits,showed
R2491	T4015	T4014	amod	neurobehavioural,traits
R2492	T4016	T4014	prep	including,traits
R2493	T4017	T4018	amod	impaired,cognition
R2494	T4018	T4016	pobj	cognition,including
R2495	T4019	T4018	amod	social,cognition
R2496	T4020	T4018	cc	and,cognition
R2497	T4021	T4022	amod	poor,inhibition
R2498	T4022	T4018	conj	inhibition,cognition
R2499	T4023	T4022	amod	verbal,inhibition
R2500	T4024	T4025	punct	[,28
R2501	T4025	T4009	parataxis	28,showed
R2502	T4026	T4025	punct	],28
R2503	T4027	T4009	punct	.,showed
R2504	T4029	T4030	compound	MRI,analysis
R2505	T4030	T4031	nsubj	analysis,revealed
R2506	T4032	T4033	amod	grey,matter
R2507	T4033	T4034	compound	matter,abnormalities
R2508	T4034	T4031	dobj	abnormalities,revealed
R2509	T4035	T4034	prep	in,abnormalities
R2510	T4036	T4037	det	the,lobe
R2511	T4037	T4035	pobj	lobe,in
R2512	T4038	T4037	amod	frontal,lobe
R2513	T4039	T4037	punct	", ",lobe
R2514	T4040	T4041	amod	temporal,lobe
R2515	T4041	T4037	conj	lobe,lobe
R2516	T4042	T4041	cc	and,lobe
R2517	T4043	T4041	conj	cerebellum,lobe
R2518	T4044	T4034	punct	", ",abnormalities
R2519	T4045	T4034	cc	and,abnormalities
R2520	T4046	T4047	amod	white,matter
R2521	T4047	T4048	compound	matter,deficits
R2522	T4048	T4034	conj	deficits,abnormalities
R2523	T4049	T4048	prep	in,deficits
R2524	T4050	T4051	det	the,callosum
R2525	T4051	T4049	pobj	callosum,in
R2526	T4052	T4051	compound	corpus,callosum
R2527	T4053	T4054	punct	[,13
R2528	T4054	T4031	parataxis	13,revealed
R2529	T4055	T4054	punct	],13
R2530	T4056	T4031	punct	.,revealed
R2531	T4058	T4059	det	The,mutation
R2532	T4059	T4061	nsubjpass	mutation,reported
R2533	T4060	T4059	amod	third,mutation
R2534	T4062	T4059	appos	1629insT,mutation
R2535	T4063	T4062	punct	(,1629insT
R2536	T4064	T4062	appos	X423L,1629insT
R2537	T4065	T4059	punct	),mutation
R2538	T4066	T4061	aux	has,reported
R2539	T4067	T4061	auxpass	been,reported
R2540	T4068	T4061	prep	in,reported
R2541	T4069	T4070	amod	several,patients
R2542	T4070	T4068	pobj	patients,in
R2543	T4071	T4070	compound	aniridia,patients
R2544	T4072	T4073	punct	[,33
R2545	T4073	T4061	parataxis	33,reported
R2546	T4074	T4073	nummod	11,33
R2547	T4075	T4073	punct	",",33
R2548	T4076	T4073	nummod	12,33
R2549	T4077	T4073	punct	",",33
R2550	T4078	T4073	nummod	27,33
R2551	T4079	T4073	punct	",",33
R2552	T4080	T4073	punct	],33
R2553	T4081	T4061	punct	.,reported
R2554	T4083	T4084	nsubj	Insertion,changes
R2555	T4085	T4083	prep	of,Insertion
R2556	T4086	T4087	det	a,nucleotide
R2557	T4087	T4085	pobj	nucleotide,of
R2558	T4088	T4087	amod	single,nucleotide
R2559	T4089	T4087	compound	T,nucleotide
R2560	T4090	T4083	prep	at,Insertion
R2561	T4091	T4090	pobj	position,at
R2562	T4092	T4091	nummod	1629,position
R2563	T4093	T4094	det	the,codon
R2564	T4094	T4084	dobj	codon,changes
R2565	T4095	T4094	compound	stop,codon
R2566	T4096	T4094	punct	(,codon
R2567	T4097	T4094	appos	TAA,codon
R2568	T4098	T4094	punct	),codon
R2569	T4099	T4084	prep	to,changes
R2570	T4100	T4101	det	a,codon
R2571	T4101	T4099	pobj	codon,to
R2572	T4102	T4101	compound	leucine,codon
R2573	T4103	T4101	punct	(,codon
R2574	T4104	T4101	appos	TTA,codon
R2575	T4105	T4101	punct	),codon
R2576	T4106	T4084	cc	and,changes
R2577	T4107	T4084	conj	generates,changes
R2578	T4108	T4109	det	a,protein
R2579	T4109	T4107	dobj	protein,generates
R2580	T4110	T4111	amod	full,length
R2581	T4111	T4109	compound	length,protein
R2582	T4112	T4109	compound	PAX6,protein
R2583	T4113	T4109	prep	with,protein
R2584	T4114	T4115	det	a,extension
R2585	T4115	T4113	pobj	extension,with
R2586	T4116	T4117	npadvmod	C,terminal
R2587	T4117	T4115	amod	terminal,extension
R2588	T4118	T4117	punct	-,terminal
R2589	T4119	T4120	dep	that,extends
R2590	T4120	T4115	relcl	extends,extension
R2591	T4121	T4120	prep	for,extends
R2592	T4122	T4123	det	a,acids
R2593	T4123	T4121	pobj	acids,for
R2594	T4124	T4123	amod	further,acids
R2595	T4125	T4123	nummod	35,acids
R2596	T4126	T4123	compound	amino,acids
R2597	T4127	T4120	prep	into,extends
R2598	T4128	T4129	det	the,region
R2599	T4129	T4127	pobj	region,into
R2600	T4130	T4129	nummod	3,region
R2601	T4131	T4130	punct	',3
R2602	T4132	T4129	amod	untranslated,region
R2603	T4133	T4084	punct	.,changes
R2604	T4135	T4136	compound	MRI,analysis
R2605	T4136	T4137	nsubj	analysis,revealed
R2606	T4138	T4136	prep	of,analysis
R2607	T4139	T4140	nummod	six,patients
R2608	T4140	T4138	pobj	patients,of
R2609	T4141	T4140	prep	with,patients
R2610	T4142	T4143	det	this,mutation
R2611	T4143	T4141	pobj	mutation,with
R2612	T4144	T4145	amod	variable,defects
R2613	T4145	T4137	dobj	defects,revealed
R2614	T4146	T4145	compound	brain,defects
R2615	T4147	T4145	prep	including,defects
R2616	T4148	T4147	pobj	absence,including
R2617	T4149	T4148	cc	or,absence
R2618	T4150	T4148	conj	hypoplasia,absence
R2619	T4151	T4148	prep	of,absence
R2620	T4152	T4153	det	the,commissure
R2621	T4153	T4151	pobj	commissure,of
R2622	T4154	T4153	amod	anterior,commissure
R2623	T4155	T4153	punct	", ",commissure
R2624	T4156	T4157	amod	pineal,gland
R2625	T4157	T4153	conj	gland,commissure
R2626	T4158	T4157	cc	and,gland
R2627	T4159	T4160	amod	olfactory,bulbs
R2628	T4160	T4157	conj	bulbs,gland
R2629	T4161	T4162	punct	[,12
R2630	T4162	T4137	parataxis	12,revealed
R2631	T4163	T4162	punct	],12
R2632	T4164	T4137	punct	.,revealed
R2633	T4166	T4167	nummod	Two,patients
R2634	T4167	T4168	nsubj	patients,had
R2635	T4168	T4169	ccomp	had,one
R2636	T4170	T4171	amod	temporal,polymicrogyria
R2637	T4171	T4168	dobj	polymicrogyria,had
R2638	T4172	T4169	punct	", ",one
R2639	T4173	T4169	prep	in,one
R2640	T4174	T4173	pobj	association,in
R2641	T4175	T4174	prep	with,association
R2642	T4176	T4175	pobj	epilepsy,with
R2643	T4177	T4178	punct	[,12
R2644	T4178	T4169	parataxis	12,one
R2645	T4179	T4178	punct	],12
R2646	T4180	T4169	punct	.,one
R2647	T4182	T4183	det	The,mutations
R2648	T4183	T4185	nsubjpass	mutations,introduced
R2649	T4184	T4183	nummod	three,mutations
R2650	T4186	T4185	auxpass	were,introduced
R2651	T4187	T4185	prep	into,introduced
R2652	T4188	T4189	det	the,construct
R2653	T4189	T4187	pobj	construct,into
R2654	T4190	T4189	compound	PAX6PST,construct
R2655	T4191	T4185	punct	", ",introduced
R2656	T4192	T4185	cc	and,introduced
R2657	T4193	T4194	amod	pairwise,tests
R2658	T4194	T4195	nsubjpass	tests,carried
R2659	T4195	T4185	conj	carried,introduced
R2660	T4196	T4195	auxpass	were,carried
R2661	T4197	T4195	prt	out,carried
R2662	T4198	T4199	aux	to,investigate
R2663	T4199	T4195	advcl	investigate,carried
R2664	T4200	T4201	det	the,interaction
R2665	T4201	T4199	dobj	interaction,investigate
R2666	T4202	T4201	prep	of,interaction
R2667	T4203	T4204	det	each,protein
R2668	T4204	T4202	pobj	protein,of
R2669	T4205	T4204	compound	mutant,protein
R2670	T4206	T4201	prep	with,interaction
R2671	T4207	T4206	pobj	HOMER3,with
R2672	T4208	T4207	punct	", ",HOMER3
R2673	T4209	T4207	conj	DNCL1,HOMER3
R2674	T4210	T4209	cc	and,DNCL1
R2675	T4211	T4209	conj	TRIM11,DNCL1
R2676	T4212	T4195	punct	.,carried
R2677	T4214	T4215	det	All,mutations
R2678	T4215	T4217	nsubj	mutations,had
R2679	T4216	T4215	nummod	three,mutations
R2680	T4218	T4219	det	a,effect
R2681	T4219	T4217	dobj	effect,had
R2682	T4220	T4219	amod	clear,effect
R2683	T4221	T4219	prep	on,effect
R2684	T4222	T4223	det	the,interactions
R2685	T4223	T4221	pobj	interactions,on
R2686	T4224	T4217	punct	.,had
R2687	T4226	T4227	det	The,mutation
R2688	T4227	T4230	nsubj	mutation,caused
R2689	T4228	T4229	advmod	most,subtle
R2690	T4229	T4227	amod	subtle,mutation
R2691	T4231	T4227	punct	(,mutation
R2692	T4232	T4227	appos	Q422R,mutation
R2693	T4233	T4227	punct	),mutation
R2694	T4234	T4235	det	a,reduction
R2695	T4235	T4230	dobj	reduction,caused
R2696	T4236	T4235	prep	in,reduction
R2697	T4237	T4238	det	the,interaction
R2698	T4238	T4236	pobj	interaction,in
R2699	T4239	T4238	prep	with,interaction
R2700	T4240	T4239	pobj	HOMER3,with
R2701	T4241	T4240	cc	and,HOMER3
R2702	T4242	T4240	conj	DNCL1,HOMER3
R2703	T4243	T4244	punct	(,Table
R2704	T4244	T4230	parataxis	Table,caused
R2705	T4245	T4244	dep	Figure,Table
R2706	T4246	T4245	nummod	3,Figure
R2707	T4247	T4244	punct	", ",Table
R2708	T4248	T4244	nummod	1,Table
R2709	T4249	T4244	punct	),Table
R2710	T4250	T4230	punct	.,caused
R2711	T4252	T4253	det	The,X423L
R2712	T4253	T4259	nsubj	X423L,reduced
R2713	T4254	T4255	npadvmod	C,terminal
R2714	T4255	T4253	amod	terminal,X423L
R2715	T4256	T4255	punct	-,terminal
R2716	T4257	T4253	compound	extension,X423L
R2717	T4258	T4253	compound	mutations,X423L
R2718	T4260	T4253	cc	and,X423L
R2719	T4261	T4262	compound	1615del10,mutations
R2720	T4262	T4253	conj	mutations,X423L
R2721	T4263	T4253	appos	both,X423L
R2722	T4264	T4259	advmod	dramatically,reduced
R2723	T4265	T4259	cc	or,reduced
R2724	T4266	T4259	conj	abolished,reduced
R2725	T4267	T4268	det	the,interaction
R2726	T4268	T4266	dobj	interaction,abolished
R2727	T4269	T4268	prep	with,interaction
R2728	T4270	T4269	pobj	HOMER3,with
R2729	T4271	T4270	cc	and,HOMER3
R2730	T4272	T4270	conj	DNCL1,HOMER3
R2731	T4273	T4274	punct	(,Table
R2732	T4274	T4266	parataxis	Table,abolished
R2733	T4275	T4274	dep	Figure,Table
R2734	T4276	T4275	nummod	3,Figure
R2735	T4277	T4274	punct	", ",Table
R2736	T4278	T4274	nummod	1,Table
R2737	T4279	T4274	punct	),Table
R2738	T4280	T4259	punct	.,reduced
R2739	T4282	T4283	nsubj	None,affected
R2740	T4284	T4282	prep	of,None
R2741	T4285	T4286	det	the,mutations
R2742	T4286	T4284	pobj	mutations,of
R2743	T4287	T4286	nummod	three,mutations
R2744	T4288	T4289	det	the,interaction
R2745	T4289	T4283	dobj	interaction,affected
R2746	T4290	T4289	prep	with,interaction
R2747	T4291	T4290	pobj	TRIM11,with
R2748	T4292	T4293	dep	which,is
R2749	T4293	T4283	advcl	is,affected
R2750	T4294	T4293	advmod	again,is
R2751	T4295	T4293	acomp	consistent,is
R2752	T4296	T4295	prep	with,consistent
R2753	T4297	T4298	det	the,hypothesis
R2754	T4298	T4296	pobj	hypothesis,with
R2755	T4299	T4300	mark	that,interacts
R2756	T4300	T4298	acl	interacts,hypothesis
R2757	T4301	T4300	nsubj	TRIM11,interacts
R2758	T4302	T4300	prep	with,interacts
R2759	T4303	T4304	det	a,part
R2760	T4304	T4302	pobj	part,with
R2761	T4305	T4306	advmod	more,terminal
R2762	T4306	T4304	amod	terminal,part
R2763	T4307	T4306	npadvmod	N,terminal
R2764	T4308	T4306	punct	-,terminal
R2765	T4309	T4304	prep	of,part
R2766	T4310	T4311	det	the,domain
R2767	T4311	T4309	pobj	domain,of
R2768	T4312	T4311	compound	PST,domain
R2769	T4313	T4283	punct	.,affected
R2778	T5078	T5079	prep	On,defined
R2779	T5080	T5081	det	the,basis
R2780	T5081	T5078	pobj	basis,On
R2781	T5082	T5081	prep	of,basis
R2782	T5083	T5084	amod	secondary,structure
R2783	T5084	T5085	compound	structure,predictions
R2784	T5085	T5082	pobj	predictions,of
R2785	T5086	T5085	cc	and,predictions
R2786	T5087	T5088	compound	amino,acid
R2787	T5088	T5089	compound	acid,conservation
R2788	T5089	T5085	conj	conservation,predictions
R2789	T5090	T5089	compound	sequence,conservation
R2790	T5091	T5079	punct	", ",defined
R2791	T5092	T5079	nsubj	we,defined
R2792	T5093	T5094	det	a,domain
R2793	T5094	T5079	dobj	domain,defined
R2794	T5095	T5094	amod	novel,domain
R2795	T5096	T5094	compound	PAX6,domain
R2796	T5097	T5094	compound	protein,domain
R2797	T5098	T5094	punct	", ",domain
R2798	T5099	T5100	dep	which,called
R2799	T5100	T5094	relcl	called,domain
R2800	T5101	T5100	nsubj	we,called
R2801	T5102	T5100	aux	have,called
R2802	T5103	T5104	det	the,peptide
R2803	T5104	T5100	oprd	peptide,called
R2804	T5105	T5106	npadvmod	C,terminal
R2805	T5106	T5104	amod	terminal,peptide
R2806	T5107	T5106	punct	-,terminal
R2807	T5108	T5079	punct	.,defined
R2808	T5110	T5111	nsubj	We,performed
R2809	T5112	T5113	nmod	yeast,screens
R2810	T5113	T5111	dobj	screens,performed
R2811	T5114	T5115	nummod	two,hybrid
R2812	T5115	T5113	compound	hybrid,screens
R2813	T5116	T5115	punct	-,hybrid
R2814	T5117	T5113	compound	library,screens
R2815	T5118	T5111	prep	with,performed
R2816	T5119	T5120	det	the,peptide
R2817	T5120	T5118	pobj	peptide,with
R2818	T5121	T5122	npadvmod	C,terminal
R2819	T5122	T5120	amod	terminal,peptide
R2820	T5123	T5122	punct	-,terminal
R2821	T5124	T5120	cc	and,peptide
R2822	T5125	T5126	det	the,domain
R2823	T5126	T5120	conj	domain,peptide
R2824	T5127	T5126	amod	whole,domain
R2825	T5128	T5126	compound	PST,domain
R2826	T5129	T5111	cc	and,performed
R2827	T5130	T5131	nsubj	we,identified
R2828	T5131	T5111	conj	identified,performed
R2829	T5132	T5133	nummod	three,proteins
R2830	T5133	T5131	dobj	proteins,identified
R2831	T5134	T5133	amod	novel,proteins
R2832	T5135	T5133	amod	interacting,proteins
R2833	T5136	T5133	punct	", ",proteins
R2834	T5137	T5133	appos	HOMER3,proteins
R2835	T5138	T5137	punct	", ",HOMER3
R2836	T5139	T5137	conj	DNCL1,HOMER3
R2837	T5140	T5139	cc	and,DNCL1
R2838	T5141	T5139	conj	TRIM11,DNCL1
R2839	T5142	T5131	punct	.,identified
R2840	T5144	T5145	prep	In,interacted
R2841	T5146	T5147	compound	library,screens
R2842	T5147	T5144	pobj	screens,In
R2843	T5148	T5145	punct	", ",interacted
R2844	T5149	T5145	nsubj	HOMER3,interacted
R2845	T5150	T5149	cc	and,HOMER3
R2846	T5151	T5149	conj	DNCL1,HOMER3
R2847	T5152	T5145	prep	with,interacted
R2848	T5153	T5154	det	the,peptide
R2849	T5154	T5152	pobj	peptide,with
R2850	T5155	T5156	npadvmod	C,terminal
R2851	T5156	T5154	amod	terminal,peptide
R2852	T5157	T5156	punct	-,terminal
R2853	T5158	T5154	cc	and,peptide
R2854	T5159	T5160	det	the,domain
R2855	T5160	T5154	conj	domain,peptide
R2856	T5161	T5160	compound	PST,domain
R2857	T5162	T5163	mark	while,interacted
R2858	T5163	T5145	advcl	interacted,interacted
R2859	T5164	T5163	nsubj	TRIM11,interacted
R2860	T5165	T5166	advmod	only,with
R2861	T5166	T5163	prep	with,interacted
R2862	T5167	T5168	det	the,domain
R2863	T5168	T5166	pobj	domain,with
R2864	T5169	T5168	compound	PST,domain
R2865	T5170	T5145	punct	", ",interacted
R2866	T5171	T5145	advcl	suggesting,interacted
R2867	T5172	T5173	mark	that,interact
R2868	T5173	T5171	ccomp	interact,suggesting
R2869	T5174	T5173	nsubj	HOMER3,interact
R2870	T5175	T5174	cc	and,HOMER3
R2871	T5176	T5174	conj	DNCL1,HOMER3
R2872	T5177	T5173	advmod	specifically,interact
R2873	T5178	T5173	prep	with,interact
R2874	T5179	T5180	det	the,peptide
R2875	T5180	T5178	pobj	peptide,with
R2876	T5181	T5182	npadvmod	C,terminal
R2877	T5182	T5180	amod	terminal,peptide
R2878	T5183	T5182	punct	-,terminal
R2879	T5184	T5185	mark	while,interacts
R2880	T5185	T5173	advcl	interacts,interact
R2881	T5186	T5185	nsubj	TRIM11,interacts
R2882	T5187	T5185	prep	with,interacts
R2883	T5188	T5189	det	a,part
R2884	T5189	T5187	pobj	part,with
R2885	T5190	T5191	advmod	more,terminal
R2886	T5191	T5189	amod	terminal,part
R2887	T5192	T5191	npadvmod	N,terminal
R2888	T5193	T5191	punct	-,terminal
R2889	T5194	T5189	prep	of,part
R2890	T5195	T5196	det	the,domain
R2891	T5196	T5194	pobj	domain,of
R2892	T5197	T5196	compound	PST,domain
R2893	T5198	T5145	punct	.,interacted
R2894	T5200	T5201	det	The,interactions
R2895	T5201	T5202	nsubjpass	interactions,confirmed
R2896	T5203	T5201	prep	between,interactions
R2897	T5204	T5205	det	the,domain
R2898	T5205	T5203	pobj	domain,between
R2899	T5206	T5205	compound	PST,domain
R2900	T5207	T5205	cc	and,domain
R2901	T5208	T5205	conj	HOMER3,domain
R2902	T5209	T5208	punct	", ",HOMER3
R2903	T5210	T5208	conj	DNCL1,HOMER3
R2904	T5211	T5210	cc	and,DNCL1
R2905	T5212	T5210	conj	TRIM11,DNCL1
R2906	T5213	T5202	auxpass	were,confirmed
R2907	T5214	T5202	prep	in,confirmed
R2908	T5215	T5216	amod	pairwise,tests
R2909	T5216	T5214	pobj	tests,in
R2910	T5217	T5202	punct	.,confirmed
R2911	T5219	T5220	nsubj	We,were
R2912	T5221	T5220	neg	not,were
R2913	T5222	T5220	acomp	able,were
R2914	T5223	T5224	aux	to,confirm
R2915	T5224	T5222	xcomp	confirm,able
R2916	T5225	T5226	det	the,interaction
R2917	T5226	T5224	dobj	interaction,confirm
R2918	T5227	T5226	prep	between,interaction
R2919	T5228	T5227	pobj	HOMER3,between
R2920	T5229	T5228	cc	or,HOMER3
R2921	T5230	T5228	conj	DNCL1,HOMER3
R2922	T5231	T5224	prep	with,confirm
R2923	T5232	T5233	det	the,construct
R2924	T5233	T5231	pobj	construct,with
R2925	T5234	T5235	npadvmod	C,terminal
R2926	T5235	T5233	amod	terminal,construct
R2927	T5236	T5235	punct	-,terminal
R2928	T5237	T5233	compound	peptide,construct
R2929	T5238	T5224	prep	in,confirm
R2930	T5239	T5240	amod	pairwise,tests
R2931	T5240	T5238	pobj	tests,in
R2932	T5241	T5220	punct	", ",were
R2933	T5242	T5220	cc	but,were
R2934	T5243	T5244	nsubj	we,showed
R2935	T5244	T5220	conj	showed,were
R2936	T5245	T5246	mark	that,was
R2937	T5246	T5244	ccomp	was,showed
R2938	T5247	T5248	det	the,peptide
R2939	T5248	T5246	nsubj	peptide,was
R2940	T5249	T5250	npadvmod	C,terminal
R2941	T5250	T5248	amod	terminal,peptide
R2942	T5251	T5250	punct	-,terminal
R2943	T5252	T5246	acomp	important,was
R2944	T5253	T5252	prep	for,important
R2945	T5254	T5255	nmod	PAX6,HOMER3
R2946	T5255	T5257	nmod	HOMER3,interaction
R2947	T5256	T5255	punct	/,HOMER3
R2948	T5257	T5253	pobj	interaction,for
R2949	T5258	T5255	cc	or,HOMER3
R2950	T5259	T5260	compound	PAX6,DNCL1
R2951	T5260	T5255	conj	DNCL1,HOMER3
R2952	T5261	T5260	punct	/,DNCL1
R2953	T5262	T5263	mark	because,interact
R2954	T5263	T5246	advcl	interact,was
R2955	T5264	T5263	nsubj	HOMER3,interact
R2956	T5265	T5264	cc	and,HOMER3
R2957	T5266	T5264	conj	DNCL1,HOMER3
R2958	T5267	T5263	aux	did,interact
R2959	T5268	T5263	neg	not,interact
R2960	T5269	T5263	prep	with,interact
R2961	T5270	T5271	det	a,construct
R2962	T5271	T5269	pobj	construct,with
R2963	T5272	T5271	compound	PST,construct
R2964	T5273	T5271	compound	domain,construct
R2965	T5274	T5271	acl	lacking,construct
R2966	T5275	T5276	det	the,peptide
R2967	T5276	T5274	dobj	peptide,lacking
R2968	T5277	T5278	npadvmod	C,terminal
R2969	T5278	T5276	amod	terminal,peptide
R2970	T5279	T5278	punct	-,terminal
R2971	T5280	T5244	punct	.,showed
R2972	T5282	T5283	nsubjpass	HOMER3,found
R2973	T5284	T5283	auxpass	is,found
R2974	T5285	T5283	prep	in,found
R2975	T5286	T5287	det	the,PSD
R2976	T5287	T5285	pobj	PSD,in
R2977	T5288	T5287	prep	of,PSD
R2978	T5289	T5288	pobj	neurons,of
R2979	T5290	T5283	cc	and,found
R2980	T5291	T5292	advmod	directly,binds
R2981	T5292	T5283	conj	binds,found
R2982	T5293	T5292	prep	to,binds
R2983	T5294	T5295	nmod	type,receptors
R2984	T5295	T5293	pobj	receptors,to
R2985	T5296	T5294	nummod	I,type
R2986	T5297	T5298	amod	metabotropic,glutamate
R2987	T5298	T5295	compound	glutamate,receptors
R2988	T5299	T5295	punct	", ",receptors
R2989	T5300	T5301	dep	which,act
R2990	T5301	T5295	relcl	act,receptors
R2991	T5302	T5301	prep	via,act
R2992	T5303	T5304	compound	phospholipase,C
R2993	T5304	T5302	pobj	C,via
R2994	T5305	T5306	aux	to,stimulate
R2995	T5306	T5301	advcl	stimulate,act
R2996	T5307	T5308	npadvmod	IP3,mediated
R2997	T5308	T5310	amod	mediated,release
R2998	T5309	T5308	punct	-,mediated
R2999	T5310	T5306	dobj	release,stimulate
R3000	T5311	T5310	prep	of,release
R3001	T5312	T5311	pobj	Ca2+,of
R3002	T5313	T5310	prep	from,release
R3003	T5314	T5315	amod	intracellular,vesicles
R3004	T5315	T5313	pobj	vesicles,from
R3005	T5316	T5317	punct	[,39
R3006	T5317	T5292	parataxis	39,binds
R3007	T5318	T5317	nummod	35,39
R3008	T5319	T5317	punct	",",39
R3009	T5320	T5317	punct	],39
R3010	T5321	T5283	punct	.,found
R3011	T5323	T5324	nsubj	HOMER3,is
R3012	T5325	T5326	det	a,member
R3013	T5326	T5324	attr	member,is
R3014	T5327	T5326	prep	of,member
R3015	T5328	T5329	det	the,family
R3016	T5329	T5327	pobj	family,of
R3017	T5330	T5329	compound	HOMER,family
R3018	T5331	T5329	prep	of,family
R3019	T5332	T5331	pobj	proteins,of
R3020	T5333	T5334	dep	that,expressed
R3021	T5334	T5329	relcl	expressed,family
R3022	T5335	T5334	auxpass	are,expressed
R3023	T5336	T5334	advmod	constitutively,expressed
R3024	T5337	T5334	prep	in,expressed
R3025	T5338	T5339	det	the,brain
R3026	T5339	T5337	pobj	brain,in
R3027	T5340	T5334	cc	and,expressed
R3028	T5341	T5334	conj	play,expressed
R3029	T5342	T5343	det	a,role
R3030	T5343	T5341	dobj	role,play
R3031	T5344	T5341	prep	in,play
R3032	T5345	T5346	amod	post-synaptic,signalling
R3033	T5346	T5344	pobj	signalling,in
R3034	T5347	T5346	cc	and,signalling
R3035	T5348	T5349	compound	receptor,trafficking
R3036	T5349	T5346	conj	trafficking,signalling
R3037	T5350	T5341	prep	by,play
R3038	T5351	T5350	pcomp	forming,by
R3039	T5352	T5353	amod	multivalent,links
R3040	T5353	T5351	dobj	links,forming
R3041	T5354	T5353	prep	with,links
R3042	T5355	T5356	amod	various,receptors
R3043	T5356	T5354	pobj	receptors,with
R3044	T5357	T5356	cc	and,receptors
R3045	T5358	T5359	compound	PSD,proteins
R3046	T5359	T5356	conj	proteins,receptors
R3047	T5360	T5359	compound	scaffolding,proteins
R3048	T5361	T5362	punct	[,35
R3049	T5362	T5324	parataxis	35,is
R3050	T5363	T5362	punct	",",35
R3051	T5364	T5362	appos	39,35
R3052	T5365	T5366	punct	-,41
R3053	T5366	T5364	prep	41,39
R3054	T5367	T5362	punct	],35
R3055	T5368	T5324	punct	.,is
R3056	T5370	T5371	compound	HOMER,proteins
R3057	T5371	T5372	nsubjpass	proteins,implicated
R3058	T5373	T5372	aux	have,implicated
R3059	T5374	T5372	advmod	also,implicated
R3060	T5375	T5372	auxpass	been,implicated
R3061	T5376	T5372	prep	in,implicated
R3062	T5377	T5378	compound	axon,guidance
R3063	T5378	T5376	pobj	guidance,in
R3064	T5379	T5372	prep	during,implicated
R3065	T5380	T5381	compound	brain,development
R3066	T5381	T5379	pobj	development,during
R3067	T5382	T5383	punct	[,42
R3068	T5383	T5372	parataxis	42,implicated
R3069	T5384	T5383	punct	],42
R3070	T5385	T5372	punct	.,implicated
R3071	T5387	T5388	nsubj	DNCL1,is
R3072	T5389	T5390	det	a,subunit
R3073	T5390	T5388	attr	subunit,is
R3074	T5391	T5390	prep	of,subunit
R3075	T5392	T5393	nummod	two,complexes
R3076	T5393	T5391	pobj	complexes,of
R3077	T5394	T5395	amod	intracellular,transport
R3078	T5395	T5393	compound	transport,complexes
R3079	T5396	T5393	compound	protein,complexes
R3080	T5397	T5393	punct	", ",complexes
R3081	T5398	T5393	appos	dynein,complexes
R3082	T5399	T5398	cc	and,dynein
R3083	T5400	T5401	compound	myosin,Va
R3084	T5401	T5398	conj	Va,dynein
R3085	T5402	T5403	punct	[,36
R3086	T5403	T5388	parataxis	36,is
R3087	T5404	T5403	punct	],36
R3088	T5405	T5388	punct	.,is
R3089	T5407	T5408	nsubjpass	Dynein,involved
R3090	T5409	T5407	cc	and,Dynein
R3091	T5410	T5411	compound	myosin,Va
R3092	T5411	T5407	conj	Va,Dynein
R3093	T5412	T5408	auxpass	are,involved
R3094	T5413	T5408	prep	in,involved
R3095	T5414	T5415	det	the,movement
R3096	T5415	T5413	pobj	movement,in
R3097	T5416	T5417	npadvmod	microtubule,based
R3098	T5417	T5415	amod	based,movement
R3099	T5418	T5417	punct	-,based
R3100	T5419	T5417	cc	and,based
R3101	T5420	T5421	npadvmod	actin,based
R3102	T5421	T5417	conj	based,based
R3103	T5422	T5421	punct	-,based
R3104	T5423	T5408	advmod	respectively,involved
R3105	T5424	T5408	prep	of,involved
R3106	T5425	T5424	pobj	proteins,of
R3107	T5426	T5425	punct	", ",proteins
R3108	T5427	T5425	conj	organelles,proteins
R3109	T5428	T5427	cc	and,organelles
R3110	T5429	T5427	conj	vesicles,organelles
R3111	T5430	T5425	prep	in,proteins
R3112	T5431	T5430	pobj	neurons,in
R3113	T5432	T5433	punct	[,37
R3114	T5433	T5408	parataxis	37,involved
R3115	T5434	T5433	nummod	36,37
R3116	T5435	T5433	punct	",",37
R3117	T5436	T5433	punct	],37
R3118	T5437	T5408	punct	.,involved
R3119	T5439	T5440	compound	Myosin,Va
R3120	T5440	T5441	nsubjpass	Va,enriched
R3121	T5442	T5441	auxpass	is,enriched
R3122	T5443	T5441	prep	in,enriched
R3123	T5444	T5445	det	the,PSD
R3124	T5445	T5443	pobj	PSD,in
R3125	T5446	T5447	punct	[,43
R3126	T5447	T5441	parataxis	43,enriched
R3127	T5448	T5447	punct	],43
R3128	T5449	T5441	punct	", ",enriched
R3129	T5450	T5441	cc	and,enriched
R3130	T5451	T5452	nsubj	DNCL1,binds
R3131	T5452	T5441	conj	binds,enriched
R3132	T5453	T5452	prep	to,binds
R3133	T5454	T5455	det	a,variety
R3134	T5455	T5453	pobj	variety,to
R3135	T5456	T5455	prep	of,variety
R3136	T5457	T5458	compound	PSD,proteins
R3137	T5458	T5456	pobj	proteins,of
R3138	T5459	T5458	prep	including,proteins
R3139	T5460	T5461	nmod	guanylate,protein
R3140	T5461	T5459	pobj	protein,including
R3141	T5462	T5461	nmod	kinase,protein
R3142	T5463	T5464	npadvmod	domain,associated
R3143	T5464	T5461	amod	associated,protein
R3144	T5465	T5464	punct	-,associated
R3145	T5466	T5467	punct	[,44
R3146	T5467	T5461	parataxis	44,protein
R3147	T5468	T5467	punct	],44
R3148	T5469	T5461	cc	and,protein
R3149	T5470	T5471	amod	neuronal,synthase
R3150	T5471	T5461	conj	synthase,protein
R3151	T5472	T5473	amod	nitric,oxide
R3152	T5473	T5471	compound	oxide,synthase
R3153	T5474	T5475	punct	[,45
R3154	T5475	T5471	parataxis	45,synthase
R3155	T5476	T5475	punct	],45
R3156	T5477	T5452	punct	.,binds
R3157	T5479	T5480	nsubj	TRIM11,is
R3158	T5481	T5482	det	a,member
R3159	T5482	T5480	attr	member,is
R3160	T5483	T5482	prep	of,member
R3161	T5484	T5485	det	the,family
R3162	T5485	T5483	pobj	family,of
R3163	T5486	T5485	nmod	mouse,family
R3164	T5487	T5488	amod	tripartite,motif
R3165	T5488	T5485	compound	motif,family
R3166	T5489	T5485	compound	protein,family
R3167	T5490	T5485	punct	(,family
R3168	T5491	T5492	advmod	also,known
R3169	T5492	T5485	acl	known,family
R3170	T5493	T5492	prep	as,known
R3171	T5494	T5495	det	the,family
R3172	T5495	T5493	pobj	family,as
R3173	T5496	T5495	compound	RBCC,family
R3174	T5497	T5480	punct	),is
R3175	T5498	T5480	punct	", ",is
R3176	T5499	T5480	cc	and,is
R3177	T5500	T5480	conj	contains,is
R3178	T5501	T5502	det	the,motifs
R3179	T5502	T5500	dobj	motifs,contains
R3180	T5503	T5502	nummod	three,motifs
R3181	T5504	T5502	amod	characteristic,motifs
R3182	T5505	T5502	amod	structural,motifs
R3183	T5506	T5502	prep	of,motifs
R3184	T5507	T5508	det	this,family
R3185	T5508	T5506	pobj	family,of
R3186	T5509	T5508	compound	protein,family
R3187	T5510	T5502	punct	", ",motifs
R3188	T5511	T5512	det	a,finger
R3189	T5512	T5502	appos	finger,motifs
R3190	T5513	T5512	compound	RING,finger
R3191	T5514	T5512	punct	", ",finger
R3192	T5515	T5516	det	a,finger
R3193	T5516	T5512	conj	finger,finger
R3194	T5517	T5518	compound	B,box
R3195	T5518	T5516	compound	box,finger
R3196	T5519	T5518	punct	-,box
R3197	T5520	T5516	compound	zinc,finger
R3198	T5521	T5516	punct	", ",finger
R3199	T5522	T5516	cc	and,finger
R3200	T5523	T5524	det	a,domain
R3201	T5524	T5516	conj	domain,finger
R3202	T5525	T5526	amod	coiled,coil
R3203	T5526	T5524	compound	coil,domain
R3204	T5527	T5502	punct	", ",motifs
R3205	T5528	T5529	advmod	as,as
R3206	T5529	T5502	cc	as,motifs
R3207	T5530	T5529	advmod	well,as
R3208	T5531	T5532	det	a,domain
R3209	T5532	T5502	conj	domain,motifs
R3210	T5533	T5532	compound	B30.2,domain
R3211	T5534	T5535	dep	that,found
R3212	T5535	T5532	relcl	found,domain
R3213	T5536	T5535	auxpass	is,found
R3214	T5537	T5535	prep	in,found
R3215	T5538	T5537	pobj	many,in
R3216	T5539	T5538	cc	but,many
R3217	T5540	T5539	neg	not,but
R3218	T5541	T5542	nmod	all,proteins
R3219	T5542	T5538	conj	proteins,many
R3220	T5543	T5542	compound	TRIM,proteins
R3221	T5544	T5545	punct	[,38
R3222	T5545	T5500	parataxis	38,contains
R3223	T5546	T5545	punct	],38
R3224	T5547	T5480	punct	.,is
R3225	T5549	T5550	nsubj	TRIM11,interacts
R3226	T5551	T5550	prep	with,interacts
R3227	T5552	T5551	pobj	Humanin,with
R3228	T5553	T5552	punct	", ",Humanin
R3229	T5554	T5555	det	a,protein
R3230	T5555	T5552	appos	protein,Humanin
R3231	T5556	T5557	dep	that,suppresses
R3232	T5557	T5555	relcl	suppresses,protein
R3233	T5558	T5559	det	the,neurotoxicity
R3234	T5559	T5557	dobj	neurotoxicity,suppresses
R3235	T5560	T5559	acl	associated,neurotoxicity
R3236	T5561	T5560	prep	with,associated
R3237	T5562	T5563	poss	Alzheimer,disease
R3238	T5563	T5561	pobj	disease,with
R3239	T5564	T5562	case	's,Alzheimer
R3240	T5565	T5566	punct	[,46
R3241	T5566	T5550	parataxis	46,interacts
R3242	T5567	T5566	punct	],46
R3243	T5568	T5550	punct	.,interacts
R3244	T5570	T5571	nsubj	TRIM11,lowers
R3245	T5572	T5573	compound	Humanin,levels
R3246	T5573	T5571	dobj	levels,lowers
R3247	T5574	T5571	prep	by,lowers
R3248	T5575	T5576	det	a,mechanism
R3249	T5576	T5574	pobj	mechanism,by
R3250	T5577	T5578	dep	that,appears
R3251	T5578	T5576	relcl	appears,mechanism
R3252	T5579	T5580	aux	to,involve
R3253	T5580	T5578	xcomp	involve,appears
R3254	T5581	T5582	npadvmod	ubiqutin,mediated
R3255	T5582	T5584	amod	mediated,degradation
R3256	T5583	T5582	punct	-,mediated
R3257	T5584	T5580	dobj	degradation,involve
R3258	T5585	T5584	amod	proteasomal,degradation
R3259	T5586	T5587	punct	[,46
R3260	T5587	T5571	parataxis	46,lowers
R3261	T5588	T5587	punct	],46
R3262	T5589	T5571	punct	.,lowers
R3263	T5591	T5592	prep	At,considered
R3264	T5593	T5591	amod	present,At
R3265	T5594	T5595	poss	our,data
R3266	T5595	T5592	nsubjpass	data,considered
R3267	T5596	T5592	aux	must,considered
R3268	T5597	T5592	auxpass	be,considered
R3269	T5598	T5592	oprd	preliminary,considered
R3270	T5599	T5600	mark	because,confirmed
R3271	T5600	T5592	advcl	confirmed,considered
R3272	T5601	T5602	det	the,interactions
R3273	T5602	T5600	nsubjpass	interactions,confirmed
R3274	T5603	T5600	aux	have,confirmed
R3275	T5604	T5600	neg	not,confirmed
R3276	T5605	T5600	auxpass	been,confirmed
R3277	T5606	T5600	prep	by,confirmed
R3278	T5607	T5608	det	any,approach
R3279	T5608	T5606	pobj	approach,by
R3280	T5609	T5608	amod	other,approach
R3281	T5610	T5592	punct	.,considered
R3282	T5612	T5613	advmod	However,is
R3283	T5614	T5613	nsubj	it,is
R3284	T5615	T5613	acomp	interesting,is
R3285	T5616	T5617	aux	to,speculate
R3286	T5617	T5613	xcomp	speculate,is
R3287	T5618	T5619	mark	that,be
R3288	T5619	T5617	ccomp	be,speculate
R3289	T5620	T5621	det	the,interaction
R3290	T5621	T5619	nsubj	interaction,be
R3291	T5622	T5621	prep	of,interaction
R3292	T5623	T5622	pobj	PAX6,of
R3293	T5624	T5621	prep	with,interaction
R3294	T5625	T5624	pobj	HOMER3,with
R3295	T5626	T5625	cc	and,HOMER3
R3296	T5627	T5625	conj	DNCL1,HOMER3
R3297	T5628	T5619	aux	may,be
R3298	T5629	T5630	det	the,basis
R3299	T5630	T5619	attr	basis,be
R3300	T5631	T5630	prep	of,basis
R3301	T5632	T5633	det	a,mechanism
R3302	T5633	T5631	pobj	mechanism,of
R3303	T5634	T5635	prep	by,causes
R3304	T5635	T5633	relcl	causes,mechanism
R3305	T5636	T5634	pobj	which,by
R3306	T5637	T5638	amod	synaptic,signalling
R3307	T5638	T5635	nsubj	signalling,causes
R3308	T5639	T5635	dobj	changes,causes
R3309	T5640	T5639	prep	in,changes
R3310	T5641	T5642	compound	gene,expression
R3311	T5642	T5640	pobj	expression,in
R3312	T5643	T5613	punct	.,is
R3313	T5645	T5646	nsubj	We,propose
R3314	T5647	T5648	mark	that,sequestered
R3315	T5648	T5646	ccomp	sequestered,propose
R3316	T5649	T5648	nsubjpass	PAX6,sequestered
R3317	T5650	T5648	auxpass	is,sequestered
R3318	T5651	T5648	prep	in,sequestered
R3319	T5652	T5653	det	the,PSD
R3320	T5653	T5651	pobj	PSD,in
R3321	T5654	T5648	prep	by,sequestered
R3322	T5655	T5654	pcomp	binding,by
R3323	T5656	T5655	prep	to,binding
R3324	T5657	T5656	pobj	HOMER3,to
R3325	T5658	T5646	punct	.,propose
R3326	T5660	T5661	mark	Since,causes
R3327	T5661	T5664	advcl	causes,released
R3328	T5662	T5663	compound	receptor,activation
R3329	T5663	T5661	nsubj	activation,causes
R3330	T5665	T5661	dobj	dissociation,causes
R3331	T5666	T5665	prep	of,dissociation
R3332	T5667	T5668	compound	HOMER,proteins
R3333	T5668	T5666	pobj	proteins,of
R3334	T5669	T5670	punct	[,35
R3335	T5670	T5661	parataxis	35,causes
R3336	T5671	T5670	punct	],35
R3337	T5672	T5664	punct	", ",released
R3338	T5673	T5664	nsubjpass	PAX6,released
R3339	T5674	T5664	aux	may,released
R3340	T5675	T5664	auxpass	be,released
R3341	T5676	T5664	prep	as,released
R3342	T5677	T5678	det	a,result
R3343	T5678	T5676	pobj	result,as
R3344	T5679	T5678	prep	of,result
R3345	T5680	T5681	amod	synaptic,activity
R3346	T5681	T5679	pobj	activity,of
R3347	T5682	T5664	punct	", ",released
R3348	T5683	T5664	advcl	allowing,released
R3349	T5684	T5685	nsubj	it,interact
R3350	T5685	T5683	ccomp	interact,allowing
R3351	T5686	T5685	aux	to,interact
R3352	T5687	T5685	prep	with,interact
R3353	T5688	T5687	pobj	DNCL1,with
R3354	T5689	T5664	punct	.,released
R3355	T5691	T5692	det	The,complex
R3356	T5692	T5696	nsubj	complex,participate
R3357	T5693	T5694	compound	PAX6,DNCL1
R3358	T5694	T5692	compound	DNCL1,complex
R3359	T5695	T5694	punct	/,DNCL1
R3360	T5697	T5696	aux	could,participate
R3361	T5698	T5696	advmod	then,participate
R3362	T5699	T5696	prep	in,participate
R3363	T5700	T5701	compound	myosin,Va
R3364	T5701	T5702	npadvmod	Va,mediated
R3365	T5702	T5704	amod	mediated,transport
R3366	T5703	T5702	punct	-,mediated
R3367	T5704	T5699	pobj	transport,in
R3368	T5705	T5704	prep	along,transport
R3369	T5706	T5707	det	the,cytoskeleton
R3370	T5707	T5705	pobj	cytoskeleton,along
R3371	T5708	T5709	npadvmod	PSD,associated
R3372	T5709	T5707	amod	associated,cytoskeleton
R3373	T5710	T5709	punct	-,associated
R3374	T5711	T5707	compound	actin,cytoskeleton
R3375	T5712	T5704	acl	followed,transport
R3376	T5713	T5712	agent	by,followed
R3377	T5714	T5715	npadvmod	dynein,mediated
R3378	T5715	T5717	amod	mediated,transport
R3379	T5716	T5715	punct	-,mediated
R3380	T5717	T5713	pobj	transport,by
R3381	T5718	T5717	prep	along,transport
R3382	T5719	T5720	det	the,network
R3383	T5720	T5718	pobj	network,along
R3384	T5721	T5720	compound	microtubule,network
R3385	T5722	T5696	punct	", ",participate
R3386	T5723	T5724	advmod	eventually,reaching
R3387	T5724	T5696	advcl	reaching,participate
R3388	T5725	T5726	det	the,nucleus
R3389	T5726	T5724	dobj	nucleus,reaching
R3390	T5727	T5728	punct	[,36
R3391	T5728	T5696	parataxis	36,participate
R3392	T5729	T5728	punct	],36
R3393	T5730	T5696	punct	.,participate
R3394	T5732	T5733	mark	Since,implicated
R3395	T5733	T5736	advcl	implicated,play
R3396	T5734	T5733	nsubjpass	TRIM11,implicated
R3397	T5735	T5733	auxpass	is,implicated
R3398	T5737	T5733	prep	in,implicated
R3399	T5738	T5739	compound	protein,degradation
R3400	T5739	T5737	pobj	degradation,in
R3401	T5740	T5741	punct	[,46
R3402	T5741	T5733	parataxis	46,implicated
R3403	T5742	T5741	punct	],46
R3404	T5743	T5736	punct	", ",play
R3405	T5744	T5736	nsubj	it,play
R3406	T5745	T5736	aux	may,play
R3407	T5746	T5747	det	a,role
R3408	T5747	T5736	dobj	role,play
R3409	T5748	T5736	prep	in,play
R3410	T5749	T5750	compound	PAX6,protein
R3411	T5750	T5751	compound	protein,turnover
R3412	T5751	T5748	pobj	turnover,in
R3413	T5752	T5736	punct	.,play
R3414	T5754	T5755	nsubj	Precedents,include
R3415	T5756	T5754	prep	for,Precedents
R3416	T5757	T5756	pobj	association,for
R3417	T5758	T5757	prep	of,association
R3418	T5759	T5760	compound	transcription,factors
R3419	T5760	T5758	pobj	factors,of
R3420	T5761	T5757	prep	with,association
R3421	T5762	T5763	det	the,density
R3422	T5763	T5761	pobj	density,with
R3423	T5764	T5763	amod	post-synaptic,density
R3424	T5765	T5755	dobj	STAT3,include
R3425	T5766	T5765	cc	and,STAT3
R3426	T5767	T5765	conj	CREB,STAT3
R3427	T5768	T5765	punct	", ",STAT3
R3428	T5769	T5770	dep	which,act
R3429	T5770	T5765	relcl	act,STAT3
R3430	T5771	T5770	prep	as,act
R3431	T5772	T5771	pobj	messengers,as
R3432	T5773	T5772	prep	between,messengers
R3433	T5774	T5775	det	the,synapse
R3434	T5775	T5773	pobj	synapse,between
R3435	T5776	T5775	cc	and,synapse
R3436	T5777	T5778	det	the,nucleus
R3437	T5778	T5775	conj	nucleus,synapse
R3438	T5779	T5780	punct	[,48
R3439	T5780	T5755	parataxis	48,include
R3440	T5781	T5780	nummod	47,48
R3441	T5782	T5780	punct	",",48
R3442	T5783	T5780	punct	],48
R3443	T5784	T5755	punct	.,include
R3444	T5786	T5787	mark	Although,is
R3445	T5787	T5794	advcl	is,is
R3446	T5788	T5789	det	the,protein
R3447	T5789	T5787	nsubj	protein,is
R3448	T5790	T5791	amod	full,length
R3449	T5791	T5789	compound	length,protein
R3450	T5792	T5791	punct	-,length
R3451	T5793	T5789	compound	PAX6,protein
R3452	T5795	T5796	advmod	predominantly,nuclear
R3453	T5796	T5787	acomp	nuclear,is
R3454	T5797	T5794	punct	", ",is
R3455	T5798	T5794	expl	there,is
R3456	T5799	T5800	amod	good,evidence
R3457	T5800	T5794	attr	evidence,is
R3458	T5801	T5800	prep	in,evidence
R3459	T5802	T5801	pobj	mouse,in
R3460	T5803	T5802	punct	", ",mouse
R3461	T5804	T5802	conj	quail,mouse
R3462	T5805	T5804	cc	and,quail
R3463	T5806	T5804	conj	nematode,quail
R3464	T5807	T5800	prep	for,evidence
R3465	T5808	T5809	det	an,isoform
R3466	T5809	T5807	pobj	isoform,for
R3467	T5810	T5811	dep	that,lacks
R3468	T5811	T5809	relcl	lacks,isoform
R3469	T5812	T5813	det	the,domain
R3470	T5813	T5811	dobj	domain,lacks
R3471	T5814	T5813	amod	paired,domain
R3472	T5815	T5811	punct	", ",lacks
R3473	T5816	T5811	conj	is,lacks
R3474	T5817	T5818	preconj	both,nuclear
R3475	T5818	T5816	acomp	nuclear,is
R3476	T5819	T5818	cc	and,nuclear
R3477	T5820	T5818	conj	cytoplasmic,nuclear
R3478	T5821	T5816	punct	", ",is
R3479	T5822	T5816	cc	and,is
R3480	T5823	T5816	conj	binds,is
R3481	T5824	T5823	dobj	DNA,binds
R3482	T5825	T5823	prep	through,binds
R3483	T5826	T5827	det	the,homeodomain
R3484	T5827	T5825	pobj	homeodomain,through
R3485	T5828	T5827	advmod	alone,homeodomain
R3486	T5829	T5830	punct	[,49
R3487	T5830	T5794	parataxis	49,is
R3488	T5831	T5832	punct	-,51
R3489	T5832	T5830	prep	51,49
R3490	T5833	T5830	punct	],49
R3491	T5834	T5794	punct	.,is
R3492	T5836	T5837	prep	In,remains
R3493	T5838	T5836	pobj	mice,In
R3494	T5839	T5840	det	the,isoform
R3495	T5840	T5844	nsubj	isoform,is
R3496	T5841	T5842	advmod	paired,less
R3497	T5842	T5840	amod	less,isoform
R3498	T5843	T5842	punct	-,less
R3499	T5844	T5837	ccomp	is,remains
R3500	T5845	T5846	advmod	relatively,abundant
R3501	T5846	T5844	acomp	abundant,is
R3502	T5847	T5844	prep	in,is
R3503	T5848	T5847	pobj	brain,in
R3504	T5849	T5850	punct	[,49
R3505	T5850	T5844	parataxis	49,is
R3506	T5851	T5850	punct	],49
R3507	T5852	T5837	punct	;,remains
R3508	T5853	T5837	advmod	however,remains
R3509	T5854	T5855	poss	its,localisation
R3510	T5855	T5837	nsubj	localisation,remains
R3511	T5856	T5855	amod	subcellular,localisation
R3512	T5857	T5855	prep	in,localisation
R3513	T5858	T5857	pobj	neurones,in
R3514	T5859	T5855	punct	", ",localisation
R3515	T5860	T5855	cc	and,localisation
R3516	T5861	T5862	det	the,possibility
R3517	T5862	T5855	conj	possibility,localisation
R3518	T5863	T5862	prep	of,possibility
R3519	T5864	T5865	det	an,association
R3520	T5865	T5863	pobj	association,of
R3521	T5866	T5865	prep	with,association
R3522	T5867	T5868	det	the,PSD
R3523	T5868	T5866	pobj	PSD,with
R3524	T5869	T5837	punct	", ",remains
R3525	T5870	T5871	aux	to,investigated
R3526	T5871	T5837	xcomp	investigated,remains
R3527	T5872	T5871	auxpass	be,investigated
R3528	T5873	T5837	punct	.,remains
R3529	T5875	T5876	prep	Regarding,found
R3530	T5877	T5878	det	the,localisation
R3531	T5878	T5875	pobj	localisation,Regarding
R3532	T5879	T5878	amod	subcellular,localisation
R3533	T5880	T5878	prep	of,localisation
R3534	T5881	T5882	det	the,proteins
R3535	T5882	T5880	pobj	proteins,of
R3536	T5883	T5882	amod	putative,proteins
R3537	T5884	T5882	amod	interacting,proteins
R3538	T5885	T5876	punct	", ",found
R3539	T5886	T5876	nsubjpass	HOMER3,found
R3540	T5887	T5876	auxpass	is,found
R3541	T5888	T5876	advmod	predominantly,found
R3542	T5889	T5876	prep	at,found
R3543	T5890	T5891	det	the,interface
R3544	T5891	T5889	pobj	interface,at
R3545	T5892	T5891	prep	between,interface
R3546	T5893	T5894	det	the,PSD
R3547	T5894	T5892	pobj	PSD,between
R3548	T5895	T5894	cc	and,PSD
R3549	T5896	T5897	det	the,cytoplasm
R3550	T5897	T5894	conj	cytoplasm,PSD
R3551	T5898	T5899	punct	[,39
R3552	T5899	T5876	parataxis	39,found
R3553	T5900	T5899	punct	],39
R3554	T5901	T5876	punct	", ",found
R3555	T5902	T5903	nsubj	DNCL1,is
R3556	T5903	T5876	conj	is,found
R3557	T5904	T5905	advmod	chiefly,cytoplasmic
R3558	T5905	T5903	acomp	cytoplasmic,is
R3559	T5906	T5903	punct	", ",is
R3560	T5907	T5908	mark	although,reported
R3561	T5908	T5903	advcl	reported,is
R3562	T5909	T5910	amod	nuclear,localisation
R3563	T5910	T5908	nsubjpass	localisation,reported
R3564	T5911	T5908	aux	has,reported
R3565	T5912	T5908	auxpass	been,reported
R3566	T5913	T5914	punct	[,51
R3567	T5914	T5903	parataxis	51,is
R3568	T5960	T5952	auxpass	been,detected
R3569	T5915	T5914	punct	],51
R3570	T5961	T5952	prep	in,detected
R3571	T5916	T5903	punct	", ",is
R3572	T5962	T5961	pobj	thymus,in
R3573	T5917	T5903	cc	and,is
R3574	T5963	T5962	cc	and,thymus
R3575	T5964	T5962	conj	lung,thymus
R3576	T5918	T5919	nsubj	TRIM11,is
R3577	T5965	T5952	cc	but,detected
R3578	T5919	T5903	conj	is,is
R3579	T5920	T5921	preconj	both,nuclear
R3580	T5966	T5967	nsubjpass	it,studied
R3581	T5921	T5919	acomp	nuclear,is
R3582	T5967	T5952	conj	studied,detected
R3583	T5968	T5967	aux	has,studied
R3584	T5969	T5967	advmod	mainly,studied
R3585	T5922	T5921	cc	and,nuclear
R3586	T5970	T5967	auxpass	been,studied
R3587	T5971	T5967	prep	in,studied
R3588	T5923	T5921	conj	cytoplasmic,nuclear
R3589	T5972	T5971	pobj	brain,in
R3590	T5973	T5974	advmod	where,found
R3591	T5974	T5972	relcl	found,brain
R3592	T5924	T5925	punct	[,38
R3593	T5975	T5974	nsubjpass	it,found
R3594	T5976	T5974	auxpass	is,found
R3595	T5925	T5919	parataxis	38,is
R3596	T5977	T5974	prep	in,found
R3597	T5978	T5979	det	the,forebrain
R3598	T5979	T5977	pobj	forebrain,in
R3599	T5980	T5979	punct	", ",forebrain
R3600	T5981	T5979	conj	hippocampus,forebrain
R3601	T5982	T5981	cc	and,hippocampus
R3602	T5926	T5925	punct	],38
R3603	T5983	T5981	conj	cerebellum,hippocampus
R3604	T5984	T5985	punct	[,39
R3605	T5985	T5967	parataxis	39,studied
R3606	T5927	T5876	punct	.,found
R3607	T5986	T5985	punct	],39
R3608	T5987	T5967	punct	.,studied
R3609	T5929	T5930	advmod	Therefore,interact
R3610	T5989	T5990	nsubj	DNCL1,have
R3611	T5991	T5989	cc	and,DNCL1
R3612	T5931	T5932	amod	cytoplasmic,PAX6
R3613	T5992	T5989	conj	TRIM11,DNCL1
R3614	T5993	T5989	appos	both,DNCL1
R3615	T5994	T5995	amod	wide,domains
R3616	T5995	T5990	dobj	domains,have
R3617	T5996	T5995	compound	expression,domains
R3618	T5932	T5930	nsubj	PAX6,interact
R3619	T5997	T5998	dep	that,include
R3620	T5998	T5995	relcl	include,domains
R3621	T5999	T6000	det	the,brain
R3622	T5933	T5930	aux	could,interact
R3623	T6000	T5998	dobj	brain,include
R3624	T6001	T6002	punct	[,38
R3625	T5934	T5930	advmod	potentially,interact
R3626	T6002	T5990	parataxis	38,have
R3627	T6003	T6002	nummod	44,38
R3628	T6004	T6002	punct	",",38
R3629	T6005	T6002	punct	],38
R3630	T5935	T5930	prep	with,interact
R3631	T6006	T5990	punct	.,have
R3632	T5936	T5937	det	all,proteins
R3633	T6008	T6009	advmod	Thus,overlaps
R3634	T6010	T6011	det	the,expression
R3635	T5937	T5935	pobj	proteins,with
R3636	T6011	T6009	nsubj	expression,overlaps
R3637	T6012	T6011	prep	of,expression
R3638	T6013	T6014	det	all,interactors
R3639	T5938	T5937	nummod	three,proteins
R3640	T6014	T6012	pobj	interactors,of
R3641	T6015	T6014	nummod	three,interactors
R3642	T6016	T6009	prep	with,overlaps
R3643	T6017	T6016	pobj	PAX6,with
R3644	T5939	T5930	punct	", ",interact
R3645	T6018	T6009	prep	at,overlaps
R3646	T6019	T6020	det	the,level
R3647	T5940	T5941	mark	while,interact
R3648	T6020	T6018	pobj	level,at
R3649	T6021	T6020	compound	tissue,level
R3650	T6022	T6023	punct	[,10
R3651	T6023	T6009	parataxis	10,overlaps
R3652	T6024	T6023	nummod	2,10
R3653	T6025	T6023	punct	",",10
R3654	T5941	T5930	advcl	interact,interact
R3655	T6026	T6023	nummod	7,10
R3656	T6027	T6023	punct	",",10
R3657	T6028	T6023	nummod	8,10
R3658	T5942	T5943	amod	nuclear,PAX6
R3659	T6029	T6023	punct	",",10
R3660	T6030	T6023	punct	],10
R3661	T6031	T6009	punct	.,overlaps
R3662	T5943	T5941	nsubj	PAX6,interact
R3663	T6033	T6034	nsubj	We,detected
R3664	T5944	T5941	aux	could,interact
R3665	T6035	T6034	dobj	co-expression,detected
R3666	T5945	T5941	prep	with,interact
R3667	T6036	T6035	prep	of,co-expression
R3668	T6037	T6036	pobj	PAX6,of
R3669	T6038	T6037	punct	", ",PAX6
R3670	T5946	T5945	pobj	TRIM11,with
R3671	T6039	T6037	conj	HOMER3,PAX6
R3672	T5947	T5946	cc	and,TRIM11
R3673	T6040	T6039	punct	", ",HOMER3
R3674	T5948	T5946	conj	DNCL1,TRIM11
R3675	T6041	T6039	conj	DNCL1,HOMER3
R3676	T6042	T6041	cc	and,DNCL1
R3677	T5949	T5930	punct	.,interact
R3678	T6043	T6041	conj	TRIM11,DNCL1
R3679	T6044	T6034	prep	by,detected
R3680	T6045	T6046	compound	RT,PCR
R3681	T5951	T5952	prep	At,detected
R3682	T6046	T6044	pobj	PCR,by
R3683	T6047	T6046	punct	-,PCR
R3684	T6048	T6034	prep	in,detected
R3685	T5953	T5954	det	the,level
R3686	T6049	T6050	amod	human,RNA
R3687	T6050	T6048	pobj	RNA,in
R3688	T6051	T6050	amod	adult,RNA
R3689	T6052	T6050	compound	brain,RNA
R3690	T5954	T5951	pobj	level,At
R3691	T6053	T6054	punct	(,IH
R3692	T6054	T6034	parataxis	IH,detected
R3693	T6055	T6054	punct	", ",IH
R3694	T5955	T5954	compound	tissue,level
R3695	T6056	T6057	compound	L,Harrison
R3696	T6057	T6054	conj	Harrison,IH
R3697	T5956	T5952	punct	", ",detected
R3698	T6058	T6057	cc	and,Harrison
R3699	T6059	T6060	compound	A,Brown
R3700	T6060	T6057	conj	Brown,Harrison
R3701	T5957	T5958	compound	HOMER3,expression
R3702	T6061	T6054	punct	", ",IH
R3703	T6062	T6063	nsubj	data,shown
R3704	T6063	T6054	ccomp	shown,IH
R3705	T6064	T6063	neg	not,shown
R3706	T6065	T6054	punct	),IH
R3707	T5958	T5952	nsubjpass	expression,detected
R3708	T5959	T5952	aux	has,detected
R3709	T6172	T6171	dobj	proteins,generating
R3710	T6066	T6034	punct	.,detected
R3711	T6068	T6069	nsubj	We,demonstrated
R3712	T6173	T6172	prep	with,proteins
R3713	T6070	T6071	mark	that,impaired
R3714	T6071	T6069	ccomp	impaired,demonstrated
R3715	T6072	T6073	det	the,interaction
R3716	T6073	T6071	nsubjpass	interaction,impaired
R3717	T6174	T6175	amod	abnormal,extensions
R3718	T6074	T6073	prep	between,interaction
R3719	T6075	T6076	det	the,domain
R3720	T6175	T6173	pobj	extensions,with
R3721	T6076	T6074	pobj	domain,between
R3722	T6077	T6076	compound	PST,domain
R3723	T6078	T6076	cc	and,domain
R3724	T6176	T6177	dep	that,expected
R3725	T6079	T6076	conj	HOMER3,domain
R3726	T6080	T6079	cc	or,HOMER3
R3727	T6081	T6079	conj	DNCL1,HOMER3
R3728	T6177	T6172	relcl	expected,proteins
R3729	T6082	T6071	auxpass	was,impaired
R3730	T6083	T6071	agent	by,impaired
R3731	T6084	T6085	nummod	three,mutations
R3732	T6178	T6177	aux	might,expected
R3733	T6085	T6083	pobj	mutations,by
R3734	T6086	T6087	advmod	naturally,occurring
R3735	T6087	T6085	amod	occurring,mutations
R3736	T6179	T6177	auxpass	be,expected
R3737	T6088	T6089	dep	that,located
R3738	T6089	T6085	relcl	located,mutations
R3739	T6090	T6089	auxpass	are,located
R3740	T6091	T6089	prep	in,located
R3741	T6180	T6181	aux	to,disrupt
R3742	T6092	T6093	det	the,peptide
R3743	T6093	T6091	pobj	peptide,in
R3744	T6181	T6177	xcomp	disrupt,expected
R3745	T6094	T6093	nmod	PAX6,peptide
R3746	T6095	T6096	npadvmod	C,terminal
R3747	T6096	T6093	amod	terminal,peptide
R3748	T6182	T6183	det	the,conformation
R3749	T6097	T6096	punct	-,terminal
R3750	T6098	T6069	punct	.,demonstrated
R3751	T6183	T6181	dobj	conformation,disrupt
R3752	T6100	T6101	det	The,mutation
R3753	T6101	T6103	nsubj	mutation,caused
R3754	T6102	T6101	compound	Q422R,mutation
R3755	T6104	T6101	punct	", ",mutation
R3756	T6105	T6106	dep	which,involves
R3757	T6184	T6183	prep	of,conformation
R3758	T6106	T6101	relcl	involves,mutation
R3759	T6107	T6108	det	a,substitution
R3760	T6108	T6106	dobj	substitution,involves
R3761	T6185	T6186	det	the,end
R3762	T6109	T6108	nmod	glutamine,substitution
R3763	T6110	T6109	prep	to,glutamine
R3764	T6186	T6184	pobj	end,of
R3765	T6111	T6110	pobj	arginine,to
R3766	T6112	T6108	prep	at,substitution
R3767	T6113	T6114	det	the,position
R3768	T6187	T6188	npadvmod	C,terminal
R3769	T6114	T6112	pobj	position,at
R3770	T6115	T6114	amod	last,position
R3771	T6116	T6117	compound	amino,acid
R3772	T6117	T6114	compound	acid,position
R3773	T6188	T6186	amod	terminal,end
R3774	T6118	T6114	prep	of,position
R3775	T6119	T6118	pobj	PAX6,of
R3776	T6189	T6188	punct	-,terminal
R3777	T6120	T6103	punct	", ",caused
R3778	T6121	T6122	det	a,reduction
R3779	T6122	T6103	dobj	reduction,caused
R3780	T6123	T6122	prep	in,reduction
R3781	T6190	T6186	prep	of,end
R3782	T6124	T6125	det	the,interaction
R3783	T6191	T6192	det	the,protein
R3784	T6125	T6123	pobj	interaction,in
R3785	T6126	T6125	prep	with,interaction
R3786	T6127	T6126	pobj	HOMER3,with
R3787	T6192	T6190	pobj	protein,of
R3788	T6128	T6127	cc	and,HOMER3
R3789	T6129	T6127	conj	DNCL1,HOMER3
R3790	T6130	T6103	punct	.,caused
R3791	T6193	T6153	punct	.,is
R3792	T6132	T6133	det	The,mutations
R3793	T6195	T6196	det	The,mutation
R3794	T6133	T6137	nsubj	mutations,reduced
R3795	T6134	T6133	nmod	X423L,mutations
R3796	T6135	T6134	cc	and,X423L
R3797	T6136	T6134	conj	1615del10,X423L
R3798	T6196	T6198	nsubj	mutation,removes
R3799	T6138	T6137	advmod	severely,reduced
R3800	T6139	T6137	cc	or,reduced
R3801	T6197	T6196	compound	1615del10,mutation
R3802	T6140	T6141	advmod	completely,abolished
R3803	T6141	T6137	conj	abolished,reduced
R3804	T6142	T6143	det	the,interaction
R3805	T6199	T6198	advmod	also,removes
R3806	T6143	T6141	dobj	interaction,abolished
R3807	T6144	T6143	prep	with,interaction
R3808	T6145	T6144	pobj	HOMER3,with
R3809	T6146	T6145	cc	and,HOMER3
R3810	T6147	T6145	conj	DNCL1,HOMER3
R3811	T6148	T6137	punct	.,reduced
R3812	T6200	T6201	det	the,acids
R3813	T6150	T6151	det	The,effect
R3814	T6151	T6153	nsubj	effect,is
R3815	T6152	T6151	amod	predicted,effect
R3816	T6201	T6198	dobj	acids,removes
R3817	T6154	T6151	prep	of,effect
R3818	T6155	T6156	det	the,mutations
R3819	T6202	T6201	amod	last,acids
R3820	T6156	T6154	pobj	mutations,of
R3821	T6157	T6156	nmod	X423L,mutations
R3822	T6203	T6201	nummod	5,acids
R3823	T6158	T6157	cc	and,X423L
R3824	T6159	T6157	conj	1615del10,X423L
R3825	T6160	T6161	aux	to,cause
R3826	T6204	T6201	compound	amino,acids
R3827	T6161	T6153	xcomp	cause,is
R3828	T6162	T6161	dobj	translation,cause
R3829	T6205	T6201	prep	of,acids
R3830	T6163	T6162	prep	into,translation
R3831	T6164	T6165	det	the,region
R3832	T6165	T6163	pobj	region,into
R3833	T6206	T6207	det	the,peptide
R3834	T6166	T6165	nummod	3,region
R3835	T6167	T6166	punct	',3
R3836	T6168	T6165	amod	untranslated,region
R3837	T6169	T6161	punct	", ",cause
R3838	T6207	T6205	pobj	peptide,of
R3839	T6170	T6171	advmod	thus,generating
R3840	T6171	T6161	advcl	generating,cause
R3841	T6208	T6209	npadvmod	C,terminal
R3842	T6209	T6207	amod	terminal,peptide
R3843	T6210	T6209	punct	-,terminal
R3844	T6278	T6275	conj	peptide,homeodomain
R3845	T6279	T6280	npadvmod	C,terminal
R3846	T6211	T6212	punct	[,28
R3847	T6280	T6278	amod	terminal,peptide
R3848	T6281	T6280	punct	-,terminal
R3849	T6282	T6250	punct	.,are
R3850	T6212	T6198	parataxis	28,removes
R3851	T6284	T6285	amod	Most,patients
R3852	T6285	T6287	nsubj	patients,are
R3853	T6213	T6212	punct	],28
R3854	T6286	T6285	compound	aniridia,patients
R3855	T6288	T6287	acomp	heterozygous,are
R3856	T6214	T6198	punct	.,removes
R3857	T6289	T6288	prep	for,heterozygous
R3858	T6290	T6289	pobj	mutations,for
R3859	T6291	T6292	dep	that,introduce
R3860	T6292	T6290	relcl	introduce,mutations
R3861	T6293	T6294	det	a,codon
R3862	T6294	T6292	dobj	codon,introduce
R3863	T6216	T6217	nsubj	None,affected
R3864	T6295	T6296	amod	premature,termination
R3865	T6296	T6294	compound	termination,codon
R3866	T6297	T6292	prep	into,introduce
R3867	T6298	T6299	det	the,frame
R3868	T6218	T6216	prep	of,None
R3869	T6299	T6297	pobj	frame,into
R3870	T6219	T6220	det	the,mutations
R3871	T6300	T6299	nmod	PAX6,frame
R3872	T6220	T6218	pobj	mutations,of
R3873	T6301	T6302	amod	open,reading
R3874	T6302	T6299	compound	reading,frame
R3875	T6303	T6304	punct	[,52
R3876	T6221	T6222	det	the,interaction
R3877	T6304	T6287	parataxis	52,are
R3878	T6305	T6304	nummod	2,52
R3879	T6306	T6304	punct	",",52
R3880	T6222	T6217	dobj	interaction,affected
R3881	T6307	T6304	punct	],52
R3882	T6223	T6222	prep	with,interaction
R3883	T6308	T6287	punct	.,are
R3884	T6310	T6311	det	These,alleles
R3885	T6224	T6223	pobj	TRIM11,with
R3886	T6311	T6312	nsubjpass	alleles,expected
R3887	T6313	T6312	aux	would,expected
R3888	T6225	T6217	punct	", ",affected
R3889	T6314	T6312	auxpass	be,expected
R3890	T6315	T6316	aux	to,encode
R3891	T6316	T6312	xcomp	encode,expected
R3892	T6226	T6217	advcl	suggesting,affected
R3893	T6317	T6318	amod	truncated,proteins
R3894	T6318	T6316	dobj	proteins,encode
R3895	T6319	T6318	cc	or,proteins
R3896	T6227	T6228	mark	that,alter
R3897	T6320	T6321	det	no,protein
R3898	T6321	T6318	conj	protein,proteins
R3899	T6322	T6323	advmod	at,all
R3900	T6228	T6226	ccomp	alter,suggesting
R3901	T6323	T6321	advmod	all,protein
R3902	T6324	T6325	mark	if,degraded
R3903	T6229	T6228	nsubj	they,alter
R3904	T6325	T6316	advcl	degraded,encode
R3905	T6326	T6327	det	the,RNA
R3906	T6230	T6228	aux	do,alter
R3907	T6327	T6325	nsubjpass	RNA,degraded
R3908	T6328	T6327	compound	mutant,RNA
R3909	T6329	T6325	auxpass	is,degraded
R3910	T6330	T6325	agent	by,degraded
R3911	T6331	T6332	npadvmod	nonsense,mediated
R3912	T6332	T6334	amod	mediated,decay
R3913	T6333	T6332	punct	-,mediated
R3914	T6231	T6228	neg	not,alter
R3915	T6334	T6330	pobj	decay,by
R3916	T6335	T6336	punct	[,52
R3917	T6336	T6312	parataxis	52,expected
R3918	T6337	T6336	punct	],52
R3919	T6232	T6233	det	the,conformation
R3920	T6338	T6312	punct	.,expected
R3921	T6233	T6228	dobj	conformation,alter
R3922	T6340	T6341	nsubj	We,propose
R3923	T6342	T6343	mark	that,explained
R3924	T6234	T6233	prep	of,conformation
R3925	T6343	T6341	ccomp	explained,propose
R3926	T6344	T6345	det	the,anomalies
R3927	T6235	T6236	det	the,part
R3928	T6345	T6343	nsubjpass	anomalies,explained
R3929	T6346	T6345	compound	brain,anomalies
R3930	T6347	T6348	dep	that,observed
R3931	T6236	T6234	pobj	part,of
R3932	T6348	T6345	relcl	observed,anomalies
R3933	T6349	T6348	aux	have,observed
R3934	T6350	T6348	auxpass	been,observed
R3935	T6237	T6238	advmod	more,terminal
R3936	T6351	T6348	prep	in,observed
R3937	T6352	T6353	compound	aniridia,patients
R3938	T6238	T6236	amod	terminal,part
R3939	T6353	T6351	pobj	patients,in
R3940	T6354	T6343	aux	may,explained
R3941	T6355	T6343	auxpass	be,explained
R3942	T6356	T6343	advmod	partly,explained
R3943	T6239	T6238	npadvmod	N,terminal
R3944	T6357	T6343	agent	by,explained
R3945	T6240	T6238	punct	-,terminal
R3946	T6241	T6236	prep	of,part
R3947	T6358	T6359	amod	impaired,interaction
R3948	T6242	T6243	det	the,domain
R3949	T6359	T6357	pobj	interaction,by
R3950	T6360	T6359	prep	between,interaction
R3951	T6361	T6360	pobj	PAX6,between
R3952	T6243	T6241	pobj	domain,of
R3953	T6362	T6361	cc	and,PAX6
R3954	T6363	T6361	conj	HOMER3,PAX6
R3955	T6364	T6361	punct	", ",PAX6
R3956	T6244	T6243	compound	PST,domain
R3957	T6365	T6361	appos	DNCL1,PAX6
R3958	T6366	T6365	cc	and,DNCL1
R3959	T6367	T6365	conj	TRIM11,DNCL1
R3960	T6245	T6217	punct	.,affected
R3961	T6368	T6341	punct	.,propose
R3962	T6247	T6248	predet	All,data
R3963	T6370	T6371	det	The,phenotype
R3964	T6371	T6373	nsubj	phenotype,result
R3965	T6372	T6371	amod	neurobehavioural,phenotype
R3966	T6374	T6371	acl	associated,phenotype
R3967	T6375	T6374	prep	with,associated
R3968	T6376	T6375	pobj	1615del10,with
R3969	T6248	T6250	nsubj	data,are
R3970	T6377	T6371	cc	and,phenotype
R3971	T6378	T6379	det	the,polymicrogyria
R3972	T6379	T6371	conj	polymicrogyria,phenotype
R3973	T6249	T6248	poss	our,data
R3974	T6380	T6379	acl	associated,polymicrogyria
R3975	T6381	T6380	prep	with,associated
R3976	T6382	T6381	pobj	X423L,with
R3977	T6251	T6250	acomp	consistent,are
R3978	T6383	T6373	aux	may,result
R3979	T6252	T6251	prep	with,consistent
R3980	T6253	T6254	det	the,hypothesis
R3981	T6254	T6252	pobj	hypothesis,with
R3982	T6384	T6373	prep	from,result
R3983	T6385	T6386	det	a,effect
R3984	T6255	T6256	mark	that,interact
R3985	T6256	T6254	acl	interact,hypothesis
R3987	T6257	T6256	nsubj	TRIM11,interact
R3990	T6258	T6256	aux	does,interact
R3993	T6259	T6256	neg	not,interact
R3996	T6260	T6256	prep	with,interact
R3999	T6261	T6262	det	the,peptide
R4002	T6262	T6260	pobj	peptide,with
R4005	T6263	T6264	npadvmod	C,terminal
R4008	T6264	T6262	amod	terminal,peptide
R4012	T6265	T6264	punct	-,terminal
R4015	T6408	T6404	relcl	characterized,mechanisms
R4016	T6409	T6408	auxpass	were,characterized
R4017	T6410	T6408	advmod	initially,characterized
R4018	T6411	T6408	prep	in,characterized
R4019	T6266	T6256	punct	", ",interact
R4020	T6412	T6413	det	the,brain
R4021	T6413	T6411	pobj	brain,in
R4022	T6414	T6402	aux	may,conserved
R4023	T6267	T6256	cc	but,interact
R4024	T6415	T6402	advmod	also,conserved
R4025	T6416	T6402	auxpass	be,conserved
R4026	T6268	T6256	conj	interacts,interact
R4027	T6417	T6402	prep	in,conserved
R4028	T6418	T6419	det	the,retina
R4029	T6419	T6417	pobj	retina,in
R4030	T6269	T6268	prep	with,interacts
R4031	T6420	T6402	punct	", ",conserved
R4032	T6421	T6402	advcl	suggesting,conserved
R4033	T6422	T6423	mark	that,have
R4034	T6270	T6271	det	the,domain
R4035	T6423	T6421	ccomp	have,suggesting
R4036	T6424	T6425	amod	impaired,interactions
R4037	T6425	T6423	nsubj	interactions,have
R4038	T6271	T6269	pobj	domain,with
R4039	T6426	T6425	nmod	PAX6,interactions
R4040	T6427	T6428	nmod	protein,protein
R4041	T6272	T6271	compound	PST,domain
R4042	T6428	T6425	compound	protein,interactions
R4043	T6429	T6428	punct	-,protein
R4044	T6430	T6423	aux	may,have
R4045	T6273	T6271	prep	between,domain
R4046	T6431	T6423	advmod	also,have
R4047	T6432	T6423	dobj	implications,have
R4048	T6433	T6432	prep	for,implications
R4049	T6274	T6275	det	the,homeodomain
R4050	T6434	T6435	det	the,defects
R4051	T6435	T6433	pobj	defects,for
R4052	T6436	T6435	amod	retinal,defects
R4053	T6275	T6273	pobj	homeodomain,between
R4054	T6437	T6435	acl	observed,defects
R4055	T6438	T6437	prep	in,observed
R4056	T6439	T6438	pobj	individuals,in
R4057	T6276	T6275	cc	and,homeodomain
R4058	T6440	T6439	prep	with,individuals
R4059	T6441	T6442	compound	PAX6,mutations
R4060	T6277	T6278	det	the,peptide
R4061	T6442	T6440	pobj	mutations,with
R4062	T6443	T6444	punct	[,54
R4063	T6444	T6399	parataxis	54,is
R4064	T6445	T6444	nummod	53,54
R4065	T6446	T6444	punct	",",54
R4066	T6447	T6444	punct	],54
R4067	T6448	T6399	punct	.,is
R4068	T6504	T6505	nsubj	We,presented
R4069	T6506	T6505	aux	have,presented
R4070	T6507	T6508	amod	preliminary,evidence
R4071	T6508	T6505	dobj	evidence,presented
R4072	T6509	T6510	mark	that,interacts
R4073	T6510	T6508	acl	interacts,evidence
R4074	T6511	T6512	det	the,regulator
R4075	T6512	T6510	nsubj	regulator,interacts
R4076	T6513	T6512	amod	neurodevelopmental,regulator
R4077	T6514	T6512	amod	transcriptional,regulator
R4078	T6515	T6512	appos	PAX6,regulator
R4079	T6516	T6510	prep	with,interacts
R4080	T6517	T6516	pobj	HOMER3,with
R4081	T6518	T6517	punct	", ",HOMER3
R4082	T6519	T6517	conj	DNCL1,HOMER3
R4083	T6520	T6519	cc	and,DNCL1
R4084	T6521	T6519	conj	TRIM11,DNCL1
R4085	T6522	T6505	punct	.,presented
R4086	T6524	T6525	nsubj	We,suggest
R4087	T6526	T6527	mark	that,is
R4088	T6527	T6525	ccomp	is,suggest
R4089	T6528	T6529	det	the,interaction
R4090	T6529	T6527	nsubj	interaction,is
R4091	T6530	T6529	prep	of,interaction
R4092	T6531	T6530	pobj	PAX6,of
R4093	T6532	T6529	prep	with,interaction
R4094	T6533	T6532	pobj	HOMER3,with
R4095	T6534	T6533	cc	and,HOMER3
R4096	T6535	T6533	conj	DNCL1,HOMER3
R4097	T6536	T6537	det	a,mechanism
R4098	T6537	T6527	attr	mechanism,is
R4099	T6538	T6539	prep	by,lead
R4100	T6539	T6537	relcl	lead,mechanism
R4101	T6540	T6538	pobj	which,by
R4102	T6541	T6542	amod	synaptic,signalling
R4103	T6542	T6539	nsubj	signalling,lead
R4104	T6543	T6539	aux	could,lead
R4105	T6544	T6539	prep	to,lead
R4106	T6545	T6546	amod	regulated,changes
R4107	T6546	T6544	pobj	changes,to
R4108	T6547	T6546	prep	in,changes
R4109	T6548	T6549	compound	gene,expression
R4110	T6549	T6547	pobj	expression,in
R4111	T6550	T6539	prep	in,lead
R4112	T6551	T6550	pobj	neurons,in
R4113	T6552	T6525	punct	.,suggest
R4114	T6554	T6555	nsubj	We,propose
R4115	T6556	T6555	advmod	also,propose
R4116	T6557	T6558	mark	that,explained
R4117	T6558	T6555	ccomp	explained,propose
R4118	T6559	T6558	nsubjpass	some,explained
R4119	T6560	T6559	prep	of,some
R4120	T6561	T6562	det	the,anomalies
R4121	T6562	T6560	pobj	anomalies,of
R4122	T6563	T6562	amod	neural,anomalies
R4123	T6564	T6562	prep	in,anomalies
R4124	T6565	T6564	pobj	patients,in
R4125	T6566	T6565	prep	with,patients
R4126	T6567	T6568	compound	PAX6,mutations
R4127	T6568	T6566	pobj	mutations,with
R4128	T6569	T6558	aux	may,explained
R4129	T6570	T6558	auxpass	be,explained
R4130	T6571	T6558	agent	by,explained
R4131	T6572	T6573	amod	impaired,interactions
R4132	T6573	T6571	pobj	interactions,by
R4133	T6574	T6575	nmod	protein,protein
R4134	T6575	T6573	compound	protein,interactions
R4135	T6576	T6575	punct	-,protein
R4136	T6577	T6555	punct	.,propose
R4137	T6595	T6596	compound	Bioinformatics,techniques
R4138	T6598	T6599	compound	Sequence,searches
R4139	T6599	T6601	nsubjpass	searches,carried
R4140	T6600	T6599	compound	database,searches
R4141	T6602	T6601	auxpass	were,carried
R4142	T6603	T6601	prt	out,carried
R4143	T6604	T6601	advcl	using,carried
R4144	T6605	T6606	det	the,program
R4145	T6606	T6604	dobj	program,using
R4146	T6607	T6606	compound	BLAST,program
R4147	T6608	T6606	amod	available,program
R4148	T6609	T6608	prep	through,available
R4149	T6610	T6611	det	the,Applications
R4150	T6611	T6609	pobj	Applications,through
R4151	T6612	T6611	compound	Bioinformatics,Applications
R4152	T6613	T6611	prep	at,Applications
R4153	T6614	T6615	det	the,Centre
R4154	T6615	T6613	pobj	Centre,at
R4155	T6616	T6617	compound	Rosalind,Franklin
R4156	T6617	T6615	compound	Franklin,Centre
R4157	T6618	T6615	prep	for,Centre
R4158	T6619	T6620	compound	Genomics,Research
R4159	T6620	T6618	pobj	Research,for
R4160	T6621	T6622	punct	[,24
R4161	T6622	T6601	parataxis	24,carried
R4162	T6623	T6622	punct	],24
R4163	T6624	T6601	punct	.,carried
R4164	T6626	T6627	compound	Protein,sequences
R4165	T6627	T6628	nsubjpass	sequences,aligned
R4166	T6629	T6630	dep	that,were
R4167	T6630	T6627	relcl	were,sequences
R4168	T6631	T6632	advmod	highly,homologous
R4169	T6632	T6630	acomp	homologous,were
R4170	T6633	T6632	prep	to,homologous
R4171	T6634	T6635	det	the,terminus
R4172	T6635	T6633	pobj	terminus,to
R4173	T6636	T6635	compound	C,terminus
R4174	T6637	T6635	punct	-,terminus
R4175	T6638	T6635	prep	of,terminus
R4176	T6639	T6640	amod	human,PAX6
R4177	T6640	T6638	pobj	PAX6,of
R4178	T6641	T6628	auxpass	were,aligned
R4179	T6642	T6628	advcl	using,aligned
R4180	T6643	T6642	dobj	CLUSTAL,using
R4181	T6644	T6645	punct	[,24
R4182	T6645	T6628	parataxis	24,aligned
R4183	T6646	T6645	punct	],24
R4184	T6647	T6628	punct	.,aligned
R4185	T6649	T6650	amod	Secondary,structure
R4186	T6650	T6651	compound	structure,prediction
R4187	T6651	T6652	nsubjpass	prediction,performed
R4188	T6653	T6652	auxpass	was,performed
R4189	T6654	T6652	advcl	using,performed
R4190	T6655	T6656	det	the,method
R4191	T6656	T6654	dobj	method,using
R4192	T6657	T6656	compound	JPRED,method
R4193	T6658	T6656	compound	consensus,method
R4194	T6659	T6660	punct	[,26
R4195	T6660	T6652	parataxis	26,performed
R4196	T6661	T6660	nummod	25,26
R4197	T6662	T6660	punct	",",26
R4198	T6663	T6660	punct	],26
R4199	T6664	T6652	punct	.,performed
R4202	T6808	T6809	nmod	Yeast,constructs
R4203	T6810	T6811	nummod	two,hybrid
R4204	T6811	T6809	compound	hybrid,constructs
R4205	T6812	T6811	punct	-,hybrid
R4206	T6814	T6815	det	All,numbering
R4207	T6815	T6820	nsubj	numbering,is
R4208	T6816	T6815	nmod	cDNA,numbering
R4209	T6817	T6816	cc	and,cDNA
R4210	T6818	T6819	compound	amino,acid
R4211	T6819	T6816	conj	acid,cDNA
R4212	T6821	T6820	prep	based,is
R4213	T6822	T6821	prep	on,based
R4214	T6823	T6824	det	the,sequences
R4215	T6824	T6822	pobj	sequences,on
R4216	T6825	T6826	amod	human,cDNA
R4217	T6826	T6824	nmod	cDNA,sequences
R4218	T6827	T6826	nmod	PAX6,cDNA
R4219	T6828	T6826	cc	and,cDNA
R4220	T6829	T6830	compound	protein,reference
R4221	T6830	T6826	conj	reference,cDNA
R4222	T6831	T6824	amod	available,sequences
R4223	T6832	T6831	prep	from,available
R4224	T6833	T6834	det	the,site
R4225	T6834	T6832	pobj	site,from
R4226	T6835	T6836	amod	Human,PAX6
R4227	T6836	T6837	nmod	PAX6,Database
R4228	T6837	T6834	compound	Database,site
R4229	T6838	T6839	amod	Allelic,Variant
R4230	T6839	T6837	compound	Variant,Database
R4231	T6840	T6834	compound	web,site
R4232	T6841	T6842	punct	[,27
R4233	T6842	T6821	parataxis	27,based
R4234	T6843	T6842	punct	],27
R4235	T6844	T6820	punct	.,is
R4236	T6846	T6847	amod	Standard,techniques
R4237	T6847	T6851	nsubjpass	techniques,used
R4238	T6848	T6847	nmod	PCR,techniques
R4239	T6849	T6848	cc	and,PCR
R4240	T6850	T6848	conj	subcloning,PCR
R4241	T6852	T6851	auxpass	were,used
R4242	T6853	T6854	aux	to,make
R4243	T6854	T6851	advcl	make,used
R4244	T6855	T6856	nummod	three,constructs
R4245	T6856	T6854	dobj	constructs,make
R4246	T6857	T6858	compound	PAX6,cDNA
R4247	T6858	T6856	compound	cDNA,constructs
R4248	T6859	T6854	prep	in,make
R4249	T6860	T6861	det	the,vector
R4250	T6861	T6859	pobj	vector,in
R4251	T6862	T6861	compound	pDBLeu,vector
R4252	T6863	T6861	compound	expression,vector
R4253	T6864	T6865	punct	(,System
R4254	T6865	T6861	parataxis	System,vector
R4255	T6866	T6865	nmod	ProQuest,System
R4256	T6867	T6868	nummod	Two,Hybrid
R4257	T6868	T6865	compound	Hybrid,System
R4258	T6869	T6868	punct	-,Hybrid
R4259	T6870	T6865	punct	", ",System
R4260	T6871	T6865	npadvmod	Invitrogen,System
R4261	T6872	T6865	punct	),System
R4262	T6873	T6861	punct	", ",vector
R4263	T6874	T6875	dep	which,generates
R4264	T6875	T6861	relcl	generates,vector
R4265	T6876	T6877	det	a,protein
R4266	T6877	T6875	dobj	protein,generates
R4267	T6878	T6877	acl	fused,protein
R4268	T6879	T6878	prep	to,fused
R4269	T6880	T6881	det	the,domain
R4270	T6881	T6879	pobj	domain,to
R4271	T6882	T6881	compound	yeast,domain
R4272	T6883	T6881	compound	GAL4,domain
R4273	T6884	T6885	compound	DNA,binding
R4274	T6885	T6881	compound	binding,domain
R4275	T6886	T6851	punct	.,used
R4276	T6888	T6889	nsubj	PAX6PST,contains
R4277	T6890	T6891	det	the,domain
R4278	T6891	T6889	dobj	domain,contains
R4279	T6892	T6891	amod	whole,domain
R4280	T6893	T6891	compound	PST,domain
R4281	T6894	T6895	punct	(,278
R4282	T6895	T6889	parataxis	278,contains
R4283	T6896	T6895	nmod	amino,278
R4284	T6897	T6895	nmod	acids,278
R4285	T6898	T6899	punct	–,422
R4286	T6899	T6895	prep	422,278
R4287	T6900	T6895	prep	of,278
R4288	T6901	T6902	det	the,protein
R4289	T6902	T6900	pobj	protein,of
R4290	T6903	T6904	amod	full,length
R4291	T6904	T6902	compound	length,protein
R4292	T6905	T6904	punct	-,length
R4293	T6906	T6902	compound	PAX6,protein
R4294	T6907	T6895	punct	),278
R4295	T6908	T6889	punct	.,contains
R4296	T6910	T6911	nsubj	Primers,were
R4297	T6912	T6913	nmod	ST001,C
R4298	T6913	T6911	attr	C,were
R4299	T6914	T6915	punct	(,forward
R4300	T6915	T6913	parataxis	forward,C
R4301	T6916	T6915	punct	),forward
R4302	T6917	T6913	nummod	5,C
R4303	T6918	T6917	punct	',5
R4304	T6919	T6913	punct	-,C
R4305	T6920	T6913	compound	AAA,C
R4306	T6921	T6913	compound	AGT,C
R4307	T6922	T6913	compound	TCG,C
R4308	T6923	T6913	compound	ACT,C
R4309	T6924	T6913	compound	GCC,C
R4310	T6925	T6913	compound	AGC,C
R4311	T6926	T6913	compound	AAC,C
R4312	T6927	T6913	compound	ACA,C
R4313	T6928	T6913	compound	CCT,C
R4314	T6929	T6913	compound	AGT,C
R4315	T6930	T6913	punct	-,C
R4316	T6931	T6913	nummod	3,C
R4317	T6932	T6913	punct	',C
R4318	T6933	T6913	cc	and,C
R4319	T6934	T6935	nmod	ST005,TTG
R4320	T6935	T6913	conj	TTG,C
R4321	T6936	T6937	punct	(,R
R4322	T6937	T6935	parataxis	R,TTG
R4323	T6938	T6937	punct	),R
R4324	T6939	T6935	nummod	5,TTG
R4325	T6940	T6939	punct	',5
R4326	T6941	T6935	punct	-,TTG
R4327	T6942	T6935	compound	TTT,TTG
R4328	T6943	T6935	compound	TGC,TTG
R4329	T6944	T6935	compound	GGC,TTG
R4330	T6945	T6935	compound	TTT,TTG
R4331	T6946	T6935	compound	TTA,TTG
R4332	T6947	T6935	compound	CTG,TTG
R4333	T6948	T6935	compound	TAA,TTG
R4334	T6949	T6935	compound	TCT,TTG
R4335	T6950	T6935	compound	TGG,TTG
R4336	T6951	T6935	compound	CCA,TTG
R4337	T6952	T6935	compound	GTA,TTG
R4338	T6953	T6935	punct	-,TTG
R4339	T6954	T6935	nummod	3,TTG
R4340	T6955	T6935	punct	',TTG
R4341	T6956	T6911	punct	.,were
R4342	T6958	T6959	nsubj	PAX6CTP,contains
R4343	T6960	T6961	det	the,peptide
R4344	T6961	T6959	dobj	peptide,contains
R4345	T6962	T6963	advmod	newly,defined
R4346	T6963	T6961	amod	defined,peptide
R4347	T6964	T6965	npadvmod	C,terminal
R4348	T6965	T6961	amod	terminal,peptide
R4349	T6966	T6965	punct	-,terminal
R4350	T6967	T6961	amod	alone,peptide
R4351	T6968	T6969	punct	(,391
R4352	T6969	T6959	parataxis	391,contains
R4353	T6970	T6971	punct	–,422
R4354	T6971	T6969	prep	422,391
R4355	T6972	T6969	punct	),391
R4356	T6973	T6959	punct	.,contains
R4357	T6975	T6976	nsubj	Primers,were
R4358	T6977	T6978	nmod	ST004,TT
R4359	T6978	T6976	attr	TT,were
R4360	T6979	T6980	punct	(,F
R4361	T6980	T6978	parataxis	F,TT
R4362	T6981	T6980	punct	),F
R4363	T6982	T6978	nummod	5,TT
R4364	T6983	T6982	punct	',5
R4365	T6984	T6978	punct	-,TT
R4366	T6985	T6978	compound	AAA,TT
R4367	T6986	T6978	compound	AGT,TT
R4368	T6987	T6978	compound	CGA,TT
R4369	T6988	T6978	compound	CTA,TT
R4370	T6989	T6978	compound	CCA,TT
R4371	T6990	T6978	compound	CTT,TT
R4372	T6991	T6978	compound	CAA,TT
R4373	T6992	T6978	compound	CAG,TT
R4374	T6993	T6978	compound	GAC,TT
R4375	T6994	T6978	compound	TCA,TT
R4376	T6995	T6978	punct	-,TT
R4377	T6996	T6978	nummod	3,TT
R4378	T6997	T6978	punct	',TT
R4379	T6998	T6978	cc	and,TT
R4380	T6999	T6978	conj	ST005,TT
R4381	T7000	T7001	punct	(,R
R4382	T7001	T6999	parataxis	R,ST005
R4383	T7002	T7001	punct	),R
R4384	T7003	T6976	punct	.,were
R4385	T7005	T7006	compound	PAX6PST,CT
R4386	T7006	T7008	nsubj	CT,contains
R4387	T7007	T7006	punct	-,CT
R4388	T7009	T7010	det	the,domain
R4389	T7010	T7008	dobj	domain,contains
R4390	T7011	T7010	compound	PST,domain
R4391	T7012	T7010	cc	minus,domain
R4392	T7013	T7014	det	the,peptide
R4393	T7014	T7010	conj	peptide,domain
R4394	T7015	T7016	npadvmod	C,terminal
R4395	T7016	T7014	amod	terminal,peptide
R4396	T7017	T7016	punct	-,terminal
R4397	T7018	T7019	punct	(,278
R4398	T7019	T7008	parataxis	278,contains
R4399	T7020	T7021	punct	–,390
R4400	T7021	T7019	prep	390,278
R4401	T7022	T7019	punct	),278
R4402	T7023	T7008	punct	.,contains
R4403	T7025	T7026	nsubjpass	This,made
R4404	T7027	T7026	auxpass	was,made
R4405	T7028	T7026	prep	by,made
R4406	T7029	T7028	pcomp	cutting,by
R4407	T7030	T7029	dobj	PAX6PST,cutting
R4408	T7031	T7029	prep	with,cutting
R4409	T7032	T7031	pobj	NdeI,with
R4410	T7033	T7032	cc	and,NdeI
R4411	T7034	T7032	conj	NotI,NdeI
R4412	T7035	T7036	aux	to,drop
R4413	T7036	T7029	advcl	drop,cutting
R4414	T7037	T7036	prt	out,drop
R4415	T7038	T7039	det	the,peptide
R4416	T7039	T7036	dobj	peptide,drop
R4417	T7040	T7041	npadvmod	C,terminal
R4418	T7041	T7039	amod	terminal,peptide
R4419	T7042	T7041	punct	-,terminal
R4420	T7043	T7029	punct	", ",cutting
R4421	T7044	T7029	cc	and,cutting
R4422	T7045	T7029	conj	inserting,cutting
R4423	T7046	T7047	det	a,linker
R4424	T7047	T7045	dobj	linker,inserting
R4425	T7048	T7047	amod	synthetic,linker
R4426	T7049	T7047	prep	between,linker
R4427	T7050	T7051	det	the,sites
R4428	T7051	T7049	pobj	sites,between
R4429	T7052	T7051	nummod	two,sites
R4430	T7053	T7051	compound	restriction,sites
R4431	T7054	T7026	punct	.,made
R4432	T7056	T7057	det	All,fragments
R4433	T7057	T7058	nsubjpass	fragments,sequenced
R4434	T7059	T7057	acl	generated,fragments
R4435	T7060	T7059	prep	by,generated
R4436	T7061	T7060	pobj	PCR,by
R4437	T7062	T7060	cc	or,by
R4438	T7063	T7060	conj	with,by
R4439	T7064	T7063	pobj	linkers,with
R4440	T7065	T7058	auxpass	were,sequenced
R4441	T7066	T7067	aux	to,check
R4442	T7067	T7058	advcl	check,sequenced
R4443	T7068	T7069	mark	that,introduced
R4444	T7069	T7067	ccomp	introduced,check
R4445	T7070	T7071	det	no,errors
R4446	T7071	T7069	nsubjpass	errors,introduced
R4447	T7072	T7069	aux	had,introduced
R4448	T7073	T7069	auxpass	been,introduced
R4449	T7074	T7058	punct	.,sequenced
R4450	T7076	T7077	det	A,construct
R4451	T7077	T7081	nsubjpass	construct,generated
R4452	T7078	T7079	compound	PAX6,domain
R4453	T7079	T7077	compound	domain,construct
R4454	T7080	T7079	compound	PST,domain
R4455	T7082	T7077	acl	containing,construct
R4456	T7083	T7084	det	the,mutation
R4457	T7084	T7082	dobj	mutation,containing
R4458	T7085	T7084	appos	1627A,mutation
R4459	T7086	T7087	punct	>,G
R4460	T7087	T7085	prep	G,1627A
R4461	T7088	T7084	punct	(,mutation
R4462	T7089	T7084	appos	Q422R,mutation
R4463	T7090	T7084	punct	),mutation
R4464	T7091	T7081	auxpass	was,generated
R4465	T7092	T7081	prep	in,generated
R4466	T7093	T7094	det	the,way
R4467	T7094	T7092	pobj	way,in
R4468	T7095	T7094	amod	same,way
R4469	T7096	T7094	prep	as,way
R4470	T7097	T7098	det	the,construct
R4471	T7098	T7096	pobj	construct,as
R4472	T7099	T7098	compound	PAX6PST,construct
R4473	T7100	T7092	punct	", ",in
R4474	T7101	T7092	cc	but,in
R4475	T7102	T7092	conj	using,in
R4476	T7103	T7104	det	the,primer
R4477	T7104	T7102	dobj	primer,using
R4478	T7105	T7104	amod	reverse,primer
R4479	T7106	T7104	compound	PCR,primer
R4480	T7107	T7108	nmod	ST006,AG
R4481	T7108	T7104	appos	AG,primer
R4482	T7109	T7108	nummod	5,AG
R4483	T7110	T7109	punct	',5
R4484	T7111	T7108	punct	-,AG
R4485	T7112	T7108	compound	TTT,AG
R4486	T7113	T7108	compound	TGC,AG
R4487	T7114	T7108	compound	GGC,AG
R4488	T7115	T7108	compound	CGC,AG
R4489	T7116	T7108	compound	TTT,AG
R4490	T7117	T7108	compound	TTA,AG
R4491	T7118	T7108	compound	CCG,AG
R4492	T7119	T7108	compound	TAA,AG
R4493	T7120	T7108	compound	TCT,AG
R4494	T7121	T7108	compound	TGG,AG
R4495	T7122	T7108	compound	CCA,AG
R4496	T7123	T7108	compound	GTA,AG
R4497	T7124	T7108	compound	TTG,AG
R4498	T7125	T7108	punct	-,AG
R4499	T7126	T7108	nummod	3,AG
R4500	T7127	T7108	punct	',AG
R4501	T7128	T7104	punct	", ",primer
R4502	T7129	T7130	dep	which,contains
R4503	T7130	T7104	relcl	contains,primer
R4504	T7131	T7132	det	the,substitution
R4505	T7132	T7130	dobj	substitution,contains
R4506	T7133	T7132	compound	mutant,substitution
R4507	T7134	T7132	compound	nucleotide,substitution
R4508	T7135	T7136	punct	(,underlined
R4509	T7136	T7104	parataxis	underlined,primer
R4510	T7137	T7136	punct	),underlined
R4511	T7138	T7081	punct	.,generated
R4512	T7140	T7141	compound	cDNA,sequences
R4513	T7141	T7142	nsubjpass	sequences,generated
R4514	T7143	T7141	acl	containing,sequences
R4515	T7144	T7145	det	the,mutations
R4516	T7145	T7143	dobj	mutations,containing
R4517	T7146	T7145	appos	1615del10,mutations
R4518	T7147	T7148	punct	[,28
R4519	T7148	T7146	parataxis	28,1615del10
R4520	T7149	T7148	punct	],28
R4521	T7150	T7146	cc	and,1615del10
R4522	T7151	T7146	conj	1629insT,1615del10
R4523	T7152	T7151	punct	(,1629insT
R4524	T7153	T7151	appos	X423L,1629insT
R4525	T7154	T7151	punct	),1629insT
R4526	T7155	T7156	punct	[,12
R4527	T7156	T7151	parataxis	12,1629insT
R4528	T7157	T7156	punct	],12
R4529	T7158	T7142	auxpass	were,generated
R4530	T7159	T7142	prep	by,generated
R4531	T7160	T7159	pobj	PCR,by
R4532	T7161	T7160	prep	from,PCR
R4533	T7162	T7163	amod	reverse,transcribed
R4534	T7163	T7164	amod	transcribed,RNA
R4535	T7164	T7161	pobj	RNA,from
R4536	T7165	T7166	punct	(,gift
R4537	T7166	T7164	parataxis	gift,RNA
R4538	T7167	T7166	det	a,gift
R4539	T7168	T7166	prep	from,gift
R4540	T7169	T7170	compound	Dr,Williamson
R4541	T7170	T7168	pobj	Williamson,from
R4542	T7171	T7170	compound	K,Williamson
R4543	T7172	T7170	cc	and,Williamson
R4544	T7173	T7174	compound	Prof,Heyningen
R4545	T7174	T7170	conj	Heyningen,Williamson
R4546	T7175	T7174	compound	V,Heyningen
R4547	T7176	T7174	compound	van,Heyningen
R4548	T7177	T7166	punct	),gift
R4549	T7178	T7142	punct	.,generated
R4550	T7180	T7181	nsubj	Primers,were
R4551	T7182	T7183	nmod	ST015,C
R4552	T7183	T7181	attr	C,were
R4553	T7184	T7185	punct	(,F
R4554	T7185	T7183	parataxis	F,C
R4555	T7186	T7185	punct	),F
R4556	T7187	T7183	nummod	5,C
R4557	T7188	T7187	punct	',5
R4558	T7189	T7183	punct	-,C
R4559	T7190	T7183	compound	CCC,C
R4560	T7191	T7183	compound	ACA,C
R4561	T7192	T7183	compound	TAT,C
R4562	T7193	T7183	compound	GCA,C
R4563	T7194	T7183	compound	GAC,C
R4564	T7195	T7183	compound	ACA,C
R4565	T7196	T7183	punct	-,C
R4566	T7197	T7183	nummod	3,C
R4567	T7198	T7183	punct	',C
R4568	T7199	T7183	cc	and,C
R4569	T7200	T7201	nmod	ST031,TC
R4570	T7201	T7183	conj	TC,C
R4571	T7202	T7203	punct	(,R
R4572	T7203	T7201	parataxis	R,TC
R4573	T7204	T7203	punct	),R
R4574	T7205	T7201	nummod	5,TC
R4575	T7206	T7205	punct	',5
R4576	T7207	T7201	punct	-,TC
R4577	T7208	T7201	compound	TTG,TC
R4578	T7209	T7201	compound	CGG,TC
R4579	T7210	T7201	compound	CCG,TC
R4580	T7211	T7201	compound	CAT,TC
R4581	T7212	T7201	compound	CCA,TC
R4582	T7213	T7201	compound	TCC,TC
R4583	T7214	T7201	compound	AGT,TC
R4584	T7215	T7201	compound	CTA,TC
R4585	T7216	T7201	compound	CAT,TC
R4586	T7217	T7201	compound	TGT,TC
R4587	T7218	T7201	punct	-,TC
R4588	T7219	T7201	nummod	3,TC
R4589	T7220	T7201	punct	',TC
R4590	T7221	T7181	punct	.,were
R4591	T7223	T7224	det	The,construct
R4592	T7224	T7226	nsubjpass	construct,cut
R4593	T7225	T7224	compound	PAX6PST,construct
R4594	T7227	T7226	auxpass	was,cut
R4595	T7228	T7226	prep	with,cut
R4596	T7229	T7228	pobj	NdeI,with
R4597	T7230	T7229	cc	and,NdeI
R4598	T7231	T7229	conj	NotI,NdeI
R4599	T7232	T7233	aux	to,release
R4600	T7233	T7226	advcl	release,cut
R4601	T7234	T7235	det	the,peptide
R4602	T7235	T7233	dobj	peptide,release
R4603	T7236	T7235	amod	normal,peptide
R4604	T7237	T7238	npadvmod	C,terminal
R4605	T7238	T7235	amod	terminal,peptide
R4606	T7239	T7238	punct	-,terminal
R4607	T7240	T7226	punct	", ",cut
R4608	T7241	T7226	cc	and,cut
R4609	T7242	T7243	det	the,sequence
R4610	T7243	T7245	nsubjpass	sequence,inserted
R4611	T7244	T7243	compound	mutant,sequence
R4612	T7245	T7226	conj	inserted,cut
R4613	T7246	T7245	auxpass	was,inserted
R4614	T7247	T7245	punct	.,inserted
R4615	T7368	T7369	nmod	Yeast,screens
R4616	T7370	T7371	nummod	two,hybrid
R4617	T7371	T7369	compound	hybrid,screens
R4618	T7372	T7371	punct	-,hybrid
R4619	T7373	T7369	compound	library,screens
R4620	T7375	T7376	det	A,library
R4621	T7376	T7380	nsubjpass	library,screened
R4622	T7377	T7378	compound	mouse,brain
R4623	T7378	T7376	compound	brain,library
R4624	T7379	T7376	compound	cDNA,library
R4625	T7381	T7382	punct	(,ProQuest
R4626	T7382	T7376	parataxis	ProQuest,library
R4627	T7383	T7382	punct	", ",ProQuest
R4628	T7384	T7382	npadvmod	Invitrogen,ProQuest
R4629	T7385	T7382	punct	),ProQuest
R4630	T7386	T7380	auxpass	was,screened
R4631	T7387	T7380	prep	with,screened
R4632	T7388	T7389	det	the,constructs
R4633	T7389	T7387	pobj	constructs,with
R4634	T7390	T7389	nmod	PAX6PST,constructs
R4635	T7391	T7390	cc	and,PAX6PST
R4636	T7392	T7390	conj	PAX6CTP,PAX6PST
R4637	T7393	T7389	compound	pDBLeu,constructs
R4638	T7394	T7380	punct	.,screened
R4639	T7396	T7397	det	The,library
R4640	T7397	T7398	nsubjpass	library,constructed
R4641	T7399	T7398	auxpass	was,constructed
R4642	T7400	T7398	prep	in,constructed
R4643	T7401	T7402	det	the,vector
R4644	T7402	T7400	pobj	vector,in
R4645	T7403	T7402	compound	pPC86,vector
R4646	T7404	T7402	punct	", ",vector
R4647	T7405	T7406	dep	which,produces
R4648	T7406	T7402	relcl	produces,vector
R4649	T7407	T7406	dobj	proteins,produces
R4650	T7408	T7407	acl	fused,proteins
R4651	T7409	T7408	prep	to,fused
R4652	T7410	T7411	det	the,domain
R4653	T7411	T7409	pobj	domain,to
R4654	T7412	T7411	compound	yeast,domain
R4655	T7413	T7411	compound	GAL4,domain
R4656	T7414	T7411	compound	activation,domain
R4657	T7415	T7398	punct	.,constructed
R4658	T7417	T7418	det	The,system
R4659	T7418	T7419	nsubj	system,uses
R4660	T7420	T7421	nummod	three,genes
R4661	T7421	T7419	dobj	genes,uses
R4662	T7422	T7423	npadvmod	GAL4,activated
R4663	T7423	T7421	amod	activated,genes
R4664	T7424	T7423	punct	-,activated
R4665	T7425	T7421	compound	reporter,genes
R4666	T7426	T7421	punct	", ",genes
R4667	T7427	T7421	appos	HIS3,genes
R4668	T7428	T7427	punct	", ",HIS3
R4669	T7429	T7427	conj	URA3,HIS3
R4670	T7430	T7429	cc	and,URA3
R4671	T7431	T7429	conj	lacZ,URA3
R4672	T7432	T7419	punct	", ",uses
R4673	T7433	T7434	aux	to,identify
R4674	T7434	T7419	advcl	identify,uses
R4675	T7435	T7436	amod	positive,interactions
R4676	T7436	T7434	dobj	interactions,identify
R4677	T7437	T7419	punct	.,uses
R4678	T7439	T7440	nsubjpass	Reporters,activated
R4679	T7441	T7440	auxpass	are,activated
R4680	T7442	T7443	advmod	when,interacts
R4681	T7443	T7440	advcl	interacts,activated
R4682	T7444	T7445	det	the,protein
R4683	T7445	T7443	nsubj	protein,interacts
R4684	T7446	T7445	compound	bait,protein
R4685	T7447	T7445	acl	fused,protein
R4686	T7448	T7447	prep	to,fused
R4687	T7449	T7450	det	the,domain
R4688	T7450	T7448	pobj	domain,to
R4689	T7451	T7450	compound	GAL4,domain
R4690	T7452	T7450	compound	DNA,domain
R4691	T7453	T7450	compound	binding,domain
R4692	T7454	T7450	punct	(,domain
R4693	T7455	T7450	appos	pDBLeu,domain
R4694	T7456	T7450	punct	),domain
R4695	T7457	T7443	prep	with,interacts
R4696	T7458	T7459	det	the,protein
R4697	T7459	T7457	pobj	protein,with
R4698	T7460	T7459	compound	prey,protein
R4699	T7461	T7459	acl	fused,protein
R4700	T7462	T7461	prep	to,fused
R4701	T7463	T7464	det	the,domain
R4702	T7464	T7462	pobj	domain,to
R4703	T7465	T7464	compound	GAL4,domain
R4704	T7466	T7464	compound	activation,domain
R4705	T7467	T7464	punct	(,domain
R4706	T7468	T7464	appos	pPC86,domain
R4707	T7469	T7464	punct	),domain
R4708	T7470	T7440	punct	", ",activated
R4709	T7471	T7472	advmod	thus,reconstituting
R4710	T7472	T7440	advcl	reconstituting,activated
R4711	T7473	T7474	compound	GAL4,function
R4712	T7474	T7472	dobj	function,reconstituting
R4713	T7475	T7440	punct	.,activated
R4714	T7477	T7478	compound	HIS3,activation
R4715	T7478	T7479	nsubj	activation,allows
R4716	T7480	T7479	dobj	growth,allows
R4717	T7481	T7479	prep	on,allows
R4718	T7482	T7481	pobj	plates,on
R4719	T7483	T7482	acl	lacking,plates
R4720	T7484	T7483	dobj	histidine,lacking
R4721	T7485	T7479	punct	.,allows
R4722	T7487	T7488	amod	Weak,activation
R4723	T7488	T7490	nsubj	activation,suppresses
R4724	T7489	T7488	compound	URA3,activation
R4725	T7491	T7490	dobj	growth,suppresses
R4726	T7492	T7490	prep	on,suppresses
R4727	T7493	T7492	pobj	plates,on
R4728	T7494	T7493	acl	containing,plates
R4729	T7495	T7496	advmod	5,orotic
R4730	T7496	T7500	amod	orotic,acid
R4731	T7497	T7496	punct	-,orotic
R4732	T7498	T7496	amod	fluro,orotic
R4733	T7499	T7496	punct	-,orotic
R4734	T7500	T7494	dobj	acid,containing
R4735	T7501	T7502	mark	while,permits
R4736	T7502	T7490	advcl	permits,suppresses
R4737	T7503	T7504	amod	strong,activation
R4738	T7504	T7502	nsubj	activation,permits
R4739	T7505	T7504	compound	URA3,activation
R4740	T7506	T7502	dobj	growth,permits
R4741	T7507	T7502	prep	on,permits
R4742	T7508	T7507	pobj	plates,on
R4743	T7509	T7508	acl	lacking,plates
R4744	T7510	T7509	dobj	uracil,lacking
R4745	T7511	T7490	punct	.,suppresses
R4746	T7513	T7514	compound	LacZ,activation
R4747	T7514	T7515	nsubj	activation,causes
R4748	T7516	T7517	compound	X,gal
R4749	T7517	T7519	nsubj	gal,turn
R4750	T7518	T7517	punct	-,gal
R4751	T7519	T7515	ccomp	turn,causes
R4752	T7520	T7519	aux	to,turn
R4753	T7521	T7519	oprd	blue,turn
R4754	T7522	T7521	prep	in,blue
R4755	T7523	T7524	det	a,assay
R4756	T7524	T7522	pobj	assay,in
R4757	T7525	T7526	compound	beta,galactosidase
R4758	T7526	T7524	compound	galactosidase,assay
R4759	T7527	T7526	punct	-,galactosidase
R4760	T7528	T7515	punct	.,causes
R4761	T7530	T7531	det	All,assays
R4762	T7531	T7532	nsubjpass	assays,carried
R4763	T7533	T7532	auxpass	were,carried
R4764	T7534	T7532	prt	out,carried
R4765	T7535	T7532	prep	in,carried
R4766	T7536	T7535	pobj	parallel,in
R4767	T7537	T7536	prep	with,parallel
R4768	T7538	T7539	det	the,strains
R4769	T7539	T7537	pobj	strains,with
R4770	T7540	T7539	nummod	five,strains
R4771	T7541	T7539	compound	ProQuest,strains
R4772	T7542	T7539	compound	control,strains
R4773	T7543	T7539	compound	yeast,strains
R4774	T7544	T7539	appos	A,strains
R4775	T7545	T7546	punct	-,E
R4776	T7546	T7544	prep	E,A
R4777	T7547	T7539	punct	", ",strains
R4778	T7548	T7549	dep	which,range
R4779	T7549	T7539	relcl	range,strains
R4780	T7550	T7549	prep	from,range
R4781	T7551	T7550	pobj	non-interactor,from
R4782	T7552	T7553	punct	(,A
R4783	T7553	T7551	parataxis	A,non-interactor
R4784	T7554	T7553	punct	),A
R4785	T7555	T7550	prep	to,from
R4786	T7556	T7557	amod	strong,interactor
R4787	T7557	T7555	pobj	interactor,to
R4788	T7558	T7559	punct	(,E
R4789	T7559	T7557	parataxis	E,interactor
R4790	T7560	T7559	punct	),E
R4791	T7561	T7532	punct	.,carried
R4792	T7563	T7564	det	All,procedures
R4793	T7564	T7565	nsubjpass	procedures,carried
R4794	T7566	T7565	auxpass	were,carried
R4795	T7567	T7565	prt	out,carried
R4796	T7568	T7565	prep	according,carried
R4797	T7569	T7568	prep	to,according
R4798	T7570	T7571	det	the,supplier
R4799	T7571	T7572	poss	supplier,protocols
R4800	T7572	T7569	pobj	protocols,to
R4801	T7573	T7571	case	's,supplier
R4802	T7574	T7565	punct	.,carried
R4803	T7576	T7577	advmod	Briefly,co-transformed
R4804	T7578	T7577	punct	", ",co-transformed
R4805	T7579	T7580	advmod	chemically,competent
R4806	T7580	T7581	amod	competent,cells
R4807	T7581	T7577	nsubjpass	cells,co-transformed
R4808	T7582	T7581	compound	MaV203,cells
R4809	T7583	T7581	compound	yeast,cells
R4810	T7584	T7577	auxpass	were,co-transformed
R4811	T7585	T7577	prep	with,co-transformed
R4812	T7586	T7587	det	the,library
R4813	T7587	T7585	pobj	library,with
R4814	T7588	T7587	compound	cDNA,library
R4815	T7589	T7587	cc	and,library
R4816	T7590	T7591	det	the,plasmid
R4817	T7591	T7587	conj	plasmid,library
R4818	T7592	T7591	compound	bait,plasmid
R4819	T7593	T7594	compound	pDBLeu,PAX6CTP
R4820	T7594	T7591	appos	PAX6CTP,plasmid
R4821	T7595	T7594	cc	or,PAX6CTP
R4822	T7596	T7597	compound	pDBLeu,PAX6PST
R4823	T7597	T7594	conj	PAX6PST,PAX6CTP
R4824	T7598	T7577	punct	.,co-transformed
R4825	T7600	T7601	nsubjpass	Transformants,plated
R4826	T7602	T7603	punct	(,107
R4827	T7603	T7600	parataxis	107,Transformants
R4828	T7604	T7603	nummod	5,107
R4829	T7605	T7603	punct	×,107
R4830	T7606	T7603	punct	),107
R4831	T7607	T7601	auxpass	were,plated
R4832	T7608	T7601	prep	on,plated
R4833	T7609	T7608	pobj	medium,on
R4834	T7610	T7609	acl	lacking,medium
R4835	T7611	T7610	dobj	histidine,lacking
R4836	T7612	T7613	aux	to,check
R4837	T7613	T7601	advcl	check,plated
R4838	T7614	T7613	prep	for,check
R4839	T7615	T7616	compound	HIS3,activation
R4840	T7616	T7614	pobj	activation,for
R4841	T7617	T7601	punct	.,plated
R4842	T7619	T7620	compound	HIS3,positives
R4843	T7620	T7621	nsubjpass	positives,assayed
R4844	T7622	T7621	auxpass	were,assayed
R4845	T7623	T7621	advmod	then,assayed
R4846	T7624	T7621	prep	for,assayed
R4847	T7625	T7626	det	all,reporters
R4848	T7626	T7624	pobj	reporters,for
R4849	T7627	T7626	nummod	3,reporters
R4850	T7628	T7621	punct	.,assayed
R4851	T7630	T7631	det	The,plasmid
R4852	T7631	T7634	nsubjpass	plasmid,isolated
R4853	T7632	T7631	compound	pPC86,plasmid
R4854	T7633	T7631	compound	prey,plasmid
R4855	T7635	T7634	auxpass	was,isolated
R4856	T7636	T7634	prep	from,isolated
R4857	T7637	T7638	det	all,positives
R4858	T7638	T7636	pobj	positives,from
R4859	T7639	T7640	compound	HIS3,LacZ
R4860	T7640	T7638	compound	LacZ,positives
R4861	T7641	T7640	punct	/,LacZ
R4862	T7642	T7640	compound	URA3,LacZ
R4863	T7643	T7640	punct	/,LacZ
R4864	T7644	T7634	cc	and,isolated
R4865	T7645	T7646	det	the,insert
R4866	T7646	T7648	nsubj	insert,sequenced
R4867	T7647	T7646	compound	cDNA,insert
R4868	T7648	T7634	conj	sequenced,isolated
R4869	T7649	T7648	punct	.,sequenced
R4870	T7651	T7652	compound	BLAST,searches
R4871	T7652	T7653	nsubjpass	searches,performed
R4872	T7654	T7653	auxpass	were,performed
R4873	T7655	T7656	aux	to,identify
R4874	T7656	T7653	advcl	identify,performed
R4875	T7657	T7658	det	the,insert
R4876	T7658	T7656	dobj	insert,identify
R4877	T7659	T7658	compound	cDNA,insert
R4878	T7660	T7661	punct	[,24
R4879	T7661	T7653	parataxis	24,performed
R4880	T7662	T7661	punct	],24
R4881	T7663	T7653	punct	.,performed
R4882	T7711	T7712	amod	Pairwise,interactions
R4883	T7714	T7715	amod	Specific,interactions
R4884	T7715	T7716	nsubjpass	interactions,tested
R4885	T7717	T7716	auxpass	were,tested
R4886	T7718	T7716	prep	by,tested
R4887	T7719	T7718	pcomp	transforming,by
R4888	T7720	T7721	amod	competent,cells
R4889	T7721	T7719	dobj	cells,transforming
R4890	T7722	T7721	compound	MaV203,cells
R4891	T7723	T7721	compound	yeast,cells
R4892	T7724	T7721	prep	with,cells
R4893	T7725	T7726	nummod	one,bait
R4894	T7726	T7727	compound	bait,construct
R4895	T7727	T7724	pobj	construct,with
R4896	T7728	T7727	punct	(,construct
R4897	T7729	T7727	prep	in,construct
R4898	T7730	T7729	pobj	pDBLeu,in
R4899	T7731	T7727	punct	),construct
R4900	T7732	T7727	cc	and,construct
R4901	T7733	T7734	nummod	one,prey
R4902	T7734	T7735	compound	prey,construct
R4903	T7735	T7727	conj	construct,construct
R4904	T7736	T7735	punct	(,construct
R4905	T7737	T7735	prep	in,construct
R4906	T7738	T7737	pobj	pPC86,in
R4907	T7739	T7719	punct	),transforming
R4908	T7740	T7719	cc	and,transforming
R4909	T7741	T7719	conj	testing,transforming
R4910	T7742	T7743	det	the,colonies
R4911	T7743	T7741	dobj	colonies,testing
R4912	T7744	T7743	amod	resulting,colonies
R4913	T7745	T7741	prep	for,testing
R4914	T7746	T7745	pobj	activation,for
R4915	T7747	T7746	prep	of,activation
R4916	T7748	T7749	det	the,reporters
R4917	T7749	T7747	pobj	reporters,of
R4918	T7750	T7749	nmod	HIS3,reporters
R4919	T7751	T7750	punct	", ",HIS3
R4920	T7752	T7750	conj	URA3,HIS3
R4921	T7753	T7752	cc	and,URA3
R4922	T7754	T7752	conj	LacZ,URA3
R4923	T7755	T7741	prep	as,testing
R4924	T7756	T7755	pcomp	before,as
R4925	T7757	T7716	punct	.,tested
R4926	T7759	T7760	aux	To,create
R4927	T7760	T7761	advcl	create,identified
R4928	T7762	T7763	det	a,clone
R4929	T7763	T7760	dobj	clone,create
R4930	T7764	T7765	amod	full,length
R4931	T7765	T7763	compound	length,clone
R4932	T7766	T7765	punct	-,length
R4933	T7767	T7763	compound	Homer3,clone
R4934	T7768	T7760	prep	for,create
R4935	T7769	T7770	amod	pairwise,tests
R4936	T7770	T7768	pobj	tests,for
R4937	T7771	T7761	punct	", ",identified
R4938	T7772	T7773	det	a,clone
R4939	T7773	T7761	nsubjpass	clone,identified
R4940	T7774	T7773	compound	cDNA,clone
R4941	T7775	T7776	punct	(,clone
R4942	T7776	T7773	parataxis	clone,clone
R4943	T7777	T7776	compound	IMAGE,clone
R4944	T7778	T7776	nummod	3602414,clone
R4945	T7779	T7776	punct	", ",clone
R4946	T7780	T7781	compound	accession,BE569374
R4947	T7781	T7776	appos	BE569374,clone
R4948	T7782	T7781	compound	number,BE569374
R4949	T7783	T7776	punct	),clone
R4950	T7784	T7773	acl	containing,clone
R4951	T7785	T7786	det	the,acids
R4952	T7786	T7784	dobj	acids,containing
R4953	T7787	T7786	amod	missing,acids
R4954	T7788	T7789	npadvmod	N,terminal
R4955	T7789	T7786	amod	terminal,acids
R4956	T7790	T7789	punct	-,terminal
R4957	T7791	T7786	nummod	70,acids
R4958	T7792	T7786	compound	amino,acids
R4959	T7793	T7761	auxpass	was,identified
R4960	T7794	T7761	prep	by,identified
R4961	T7795	T7796	det	a,search
R4962	T7796	T7794	pobj	search,by
R4963	T7797	T7796	compound	BLAST,search
R4964	T7798	T7796	prep	of,search
R4965	T7799	T7800	det	the,database
R4966	T7800	T7798	pobj	database,of
R4967	T7801	T7800	compound	EST,database
R4968	T7802	T7803	compound	nucleotide,sequence
R4969	T7803	T7800	compound	sequence,database
R4970	T7804	T7761	cc	and,identified
R4971	T7805	T7761	conj	obtained,identified
R4972	T7806	T7805	prep	from,obtained
R4973	T7807	T7808	det	the,Centre
R4974	T7808	T7806	pobj	Centre,from
R4975	T7809	T7810	compound	Rosalind,Franklin
R4976	T7810	T7808	compound	Franklin,Centre
R4977	T7811	T7808	prep	for,Centre
R4978	T7812	T7813	compound	Genomics,Research
R4979	T7813	T7811	pobj	Research,for
R4980	T7814	T7761	punct	.,identified
R4981	T7816	T7817	det	The,fragment
R4982	T7817	T7819	nsubj	fragment,amplified
R4983	T7818	T7817	amod	missing,fragment
R4984	T7820	T7819	aux	was,amplified
R4985	T7821	T7819	prep	from,amplified
R4986	T7822	T7823	det	the,clone
R4987	T7823	T7821	pobj	clone,from
R4988	T7824	T7823	compound	IMAGE,clone
R4989	T7825	T7819	prep	by,amplified
R4990	T7826	T7825	pobj	PCR,by
R4991	T7827	T7819	cc	and,amplified
R4992	T7828	T7819	conj	inserted,amplified
R4993	T7829	T7828	prep	into,inserted
R4994	T7830	T7831	det	the,plasmid
R4995	T7831	T7829	pobj	plasmid,into
R4996	T7832	T7833	compound	pPC86,Homer3
R4997	T7833	T7831	compound	Homer3,plasmid
R4998	T7834	T7833	punct	-,Homer3
R4999	T7835	T7836	aux	to,create
R5000	T7836	T7819	advcl	create,amplified
R5001	T7837	T7838	det	a,construct
R5002	T7838	T7836	dobj	construct,create
R5003	T7839	T7840	amod	full,length
R5004	T7840	T7838	compound	length,construct
R5005	T7841	T7840	punct	-,length
R5006	T7842	T7838	compound	expression,construct
R5007	T7843	T7819	punct	.,amplified
R5008	T7962	T7963	amod	Semi-quantitative,PCR
R5009	T7965	T7966	aux	To,check
R5010	T7966	T7967	advcl	check,performed
R5011	T7968	T7969	det	the,representation
R5012	T7969	T7966	dobj	representation,check
R5013	T7970	T7969	amod	relative,representation
R5014	T7971	T7969	prep	of,representation
R5015	T7972	T7971	pobj	clones,of
R5016	T7973	T7969	prep	in,representation
R5017	T7974	T7975	det	the,library
R5018	T7975	T7973	pobj	library,in
R5019	T7976	T7975	compound	cDNA,library
R5020	T7977	T7967	punct	", ",performed
R5021	T7978	T7979	amod	semi-quantitative,PCR
R5022	T7979	T7967	nsubjpass	PCR,performed
R5023	T7980	T7967	auxpass	was,performed
R5024	T7981	T7967	prep	on,performed
R5025	T7982	T7981	pobj	Pax6,on
R5026	T7983	T7982	punct	", ",Pax6
R5027	T7984	T7982	conj	Homer3,Pax6
R5028	T7985	T7984	punct	", ",Homer3
R5029	T7986	T7984	conj	Dncl1,Homer3
R5030	T7987	T7986	punct	", ",Dncl1
R5031	T7988	T7986	conj	Trim11,Dncl1
R5032	T7989	T7988	cc	and,Trim11
R5033	T7990	T7991	det	the,genes
R5034	T7991	T7988	conj	genes,Trim11
R5035	T7992	T7993	advmod	constitutively,expressed
R5036	T7993	T7991	amod	expressed,genes
R5037	T7994	T7991	appos	Gapdh,genes
R5038	T7995	T7994	cc	and,Gapdh
R5039	T7996	T7994	conj	Atp5a1,Gapdh
R5040	T7997	T7998	punct	[,30
R5041	T7998	T7967	parataxis	30,performed
R5042	T7999	T7998	nummod	29,30
R5043	T8000	T7998	punct	",",30
R5044	T8001	T7998	punct	],30
R5045	T8002	T7967	punct	.,performed
R5046	T8004	T8005	nsubjpass	Primers,designed
R5047	T8006	T8005	auxpass	were,designed
R5048	T8007	T8008	aux	to,cross
R5049	T8008	T8005	advcl	cross,designed
R5050	T8009	T8010	advmod	at,one
R5051	T8010	T8012	nummod	one,intron
R5052	T8011	T8010	advmod	least,one
R5053	T8012	T8008	dobj	intron,cross
R5054	T8013	T8005	punct	", ",designed
R5055	T8014	T8015	mark	so,amplified
R5056	T8015	T8005	advcl	amplified,designed
R5057	T8016	T8015	mark	that,amplified
R5058	T8017	T8018	advmod	only,clones
R5059	T8018	T8015	nsubjpass	clones,amplified
R5060	T8019	T8020	advmod	correctly,spliced
R5061	T8020	T8018	amod	spliced,clones
R5062	T8021	T8015	auxpass	were,amplified
R5063	T8022	T8005	punct	.,designed
R5064	T8024	T8025	compound	Primer,sequences
R5065	T8025	T8026	nsubj	sequences,were
R5066	T8027	T8026	punct	: ,were
R5067	T8028	T8026	attr	Pax6,were
R5068	T8029	T8028	punct	-,Pax6
R5069	T8030	T8031	compound	F,CTG
R5070	T8031	T8028	appos	CTG,Pax6
R5071	T8032	T8031	compound	CAG,CTG
R5072	T8033	T8031	compound	CCA,CTG
R5073	T8034	T8031	compound	AAA,CTG
R5074	T8035	T8031	compound	TAG,CTG
R5075	T8036	T8031	compound	ATC,CTG
R5076	T8037	T8031	compound	TAC,CTG
R5077	T8038	T8028	punct	;,Pax6
R5078	T8039	T8028	appos	Pax6,Pax6
R5079	T8040	T8039	punct	-,Pax6
R5080	T8041	T8042	compound	R,TT
R5081	T8042	T8039	appos	TT,Pax6
R5082	T8043	T8042	compound	CGA,TT
R5083	T8044	T8042	compound	TCA,TT
R5084	T8045	T8042	compound	CAT,TT
R5085	T8046	T8042	compound	GCT,TT
R5086	T8047	T8042	compound	CTC,TT
R5087	T8048	T8042	compound	TCC,TT
R5088	T8049	T8028	punct	;,Pax6
R5089	T8050	T8028	appos	Homer3,Pax6
R5090	T8051	T8050	punct	-,Homer3
R5091	T8052	T8053	compound	F,AGC
R5092	T8053	T8050	appos	AGC,Homer3
R5093	T8054	T8053	compound	CCC,AGC
R5094	T8055	T8053	compound	AGG,AGC
R5095	T8056	T8053	compound	TGG,AGC
R5096	T8057	T8053	compound	CTG,AGC
R5097	T8058	T8053	compound	TAG,AGC
R5098	T8059	T8028	punct	;,Pax6
R5099	T8060	T8028	appos	Homer3,Pax6
R5100	T8061	T8060	punct	-,Homer3
R5101	T8062	T8063	compound	R,G
R5102	T8063	T8060	appos	G,Homer3
R5103	T8064	T8063	compound	CTC,G
R5104	T8065	T8063	compound	TAC,G
R5105	T8066	T8063	compound	ACA,G
R5106	T8067	T8063	compound	GTG,G
R5107	T8068	T8063	compound	CAA,G
R5108	T8069	T8063	compound	AGC,G
R5109	T8070	T8063	compound	TCA,G
R5110	T8071	T8028	punct	;,Pax6
R5111	T8072	T8028	appos	Trim11,Pax6
R5112	T8073	T8072	punct	-,Trim11
R5113	T8074	T8075	compound	F,CTG
R5114	T8075	T8072	appos	CTG,Trim11
R5115	T8076	T8075	compound	GTG,CTG
R5116	T8077	T8075	compound	CAG,CTG
R5117	T8078	T8075	compound	GAT,CTG
R5118	T8079	T8075	compound	GTG,CTG
R5119	T8080	T8075	compound	AAG,CTG
R5120	T8081	T8028	punct	;,Pax6
R5121	T8082	T8028	appos	Trim11,Pax6
R5122	T8083	T8082	punct	-,Trim11
R5123	T8084	T8085	compound	R,GG
R5124	T8085	T8082	appos	GG,Trim11
R5125	T8086	T8085	compound	GCC,GG
R5126	T8087	T8085	compound	TGC,GG
R5127	T8088	T8085	compound	AGA,GG
R5128	T8089	T8085	compound	TAG,GG
R5129	T8090	T8085	compound	TCA,GG
R5130	T8091	T8085	compound	TAG,GG
R5131	T8092	T8028	punct	;,Pax6
R5132	T8093	T8028	appos	Dncl1,Pax6
R5133	T8094	T8093	punct	-,Dncl1
R5134	T8095	T8096	compound	F,G
R5135	T8096	T8093	appos	G,Dncl1
R5136	T8097	T8096	compound	CAA,G
R5137	T8098	T8096	compound	AAA,G
R5138	T8099	T8096	compound	TGC,G
R5139	T8100	T8096	compound	AGA,G
R5140	T8101	T8096	compound	CAT,G
R5141	T8102	T8096	compound	GTC,G
R5142	T8103	T8028	punct	;,Pax6
R5143	T8104	T8028	appos	Dncl1,Pax6
R5144	T8105	T8104	punct	-,Dncl1
R5145	T8106	T8107	compound	R,GGG
R5146	T8107	T8104	appos	GGG,Dncl1
R5147	T8108	T8107	compound	CTA,GGG
R5148	T8109	T8107	compound	AGG,GGG
R5149	T8110	T8107	compound	GAG,GGG
R5150	T8111	T8107	compound	AAA,GGG
R5151	T8112	T8107	compound	AAA,GGG
R5152	T8113	T8107	compound	ATG,GGG
R5153	T8114	T8028	punct	;,Pax6
R5154	T8115	T8116	compound	Gapdh,F
R5155	T8116	T8028	appos	F,Pax6
R5156	T8117	T8116	punct	-,F
R5157	T8118	T8116	punct	: ,F
R5158	T8119	T8120	compound	CAT,GC
R5159	T8120	T8116	appos	GC,F
R5160	T8121	T8120	compound	CAC,GC
R5161	T8122	T8120	compound	CAT,GC
R5162	T8123	T8120	compound	CTT,GC
R5163	T8124	T8120	compound	CCA,GC
R5164	T8125	T8120	compound	GGA,GC
R5165	T8126	T8028	punct	;,Pax6
R5166	T8127	T8128	compound	Gapdh,R
R5167	T8128	T8028	appos	R,Pax6
R5168	T8129	T8128	punct	-,R
R5169	T8130	T8128	punct	: ,R
R5170	T8131	T8132	compound	ATG,TT
R5171	T8132	T8128	appos	TT,R
R5172	T8133	T8132	compound	ACC,TT
R5173	T8134	T8132	compound	TTG,TT
R5174	T8135	T8132	compound	CCC,TT
R5175	T8136	T8132	compound	ACA,TT
R5176	T8137	T8132	compound	GCC,TT
R5177	T8138	T8028	punct	;,Pax6
R5178	T8139	T8140	compound	Atp5a1,F
R5179	T8140	T8028	appos	F,Pax6
R5180	T8141	T8140	punct	-,F
R5181	T8142	T8140	punct	: ,F
R5182	T8143	T8144	compound	CAC,CA
R5183	T8144	T8140	appos	CA,F
R5184	T8145	T8144	compound	ACG,CA
R5185	T8146	T8144	compound	TGA,CA
R5186	T8147	T8144	compound	GAT,CA
R5187	T8148	T8144	compound	GTC,CA
R5188	T8149	T8144	compound	CTC,CA
R5189	T8150	T8028	punct	;,Pax6
R5190	T8151	T8152	compound	Atp5a1,R
R5191	T8152	T8028	appos	R,Pax6
R5192	T8153	T8152	punct	-,R
R5193	T8154	T8152	punct	: ,R
R5194	T8155	T8156	compound	CAC,A
R5195	T8156	T8152	appos	A,R
R5196	T8157	T8156	compound	AGA,A
R5197	T8158	T8156	compound	GAT,A
R5198	T8159	T8156	compound	TCG,A
R5199	T8160	T8156	compound	GGG,A
R5200	T8161	T8156	compound	ATA,A
R5201	T8162	T8026	punct	.,were
R5202	T8164	T8165	nummod	10,ng
R5203	T8165	T8166	compound	ng,cDNA
R5204	T8166	T8168	nsubjpass	cDNA,amplified
R5205	T8167	T8166	compound	library,cDNA
R5206	T8169	T8168	auxpass	were,amplified
R5207	T8170	T8168	prep	in,amplified
R5208	T8171	T8172	det	a,reaction
R5209	T8172	T8170	pobj	reaction,in
R5210	T8173	T8172	acl	containing,reaction
R5211	T8174	T8175	nummod	1,buffer
R5212	T8175	T8173	dobj	buffer,containing
R5213	T8176	T8174	punct	x,1
R5214	T8177	T8175	compound	AmpliTaq,buffer
R5215	T8178	T8175	compound	polymerase,buffer
R5216	T8179	T8180	punct	(,Elmer
R5217	T8180	T8175	parataxis	Elmer,buffer
R5218	T8181	T8180	compound	Perkin,Elmer
R5219	T8182	T8180	punct	),Elmer
R5220	T8183	T8175	punct	", ",buffer
R5221	T8184	T8185	nummod	1.5,mM
R5222	T8185	T8186	compound	mM,MgCl2
R5223	T8186	T8175	conj	MgCl2,buffer
R5224	T8187	T8186	punct	", ",MgCl2
R5225	T8188	T8189	nmod	200μM,primer
R5226	T8189	T8186	conj	primer,MgCl2
R5227	T8190	T8189	det	each,primer
R5228	T8191	T8189	cc	and,primer
R5229	T8192	T8193	nummod	2.5,units
R5230	T8193	T8189	conj	units,primer
R5231	T8194	T8193	prep	of,units
R5232	T8195	T8196	compound	AmpliTaq,polymerase
R5233	T8196	T8194	pobj	polymerase,of
R5234	T8197	T8198	punct	(,Elmer
R5235	T8198	T8196	parataxis	Elmer,polymerase
R5236	T8199	T8198	compound	Perkin,Elmer
R5237	T8200	T8198	punct	),Elmer
R5238	T8201	T8168	punct	.,amplified
R5239	T8203	T8204	compound	PCR,conditions
R5240	T8204	T8205	nsubj	conditions,were
R5241	T8206	T8205	punct	(,were
R5242	T8207	T8208	nummod	95,°C
R5243	T8208	T8205	attr	°C,were
R5244	T8209	T8208	prep	for,°C
R5245	T8210	T8211	nummod	30,sec
R5246	T8211	T8209	pobj	sec,for
R5247	T8212	T8208	punct	),°C
R5248	T8213	T8208	punct	×,°C
R5249	T8214	T8208	appos	1,°C
R5250	T8215	T8208	punct	", ",°C
R5251	T8216	T8217	punct	(,°C
R5252	T8217	T8208	conj	°C,°C
R5253	T8218	T8217	nummod	94,°C
R5254	T8219	T8217	prep	for,°C
R5255	T8220	T8221	nummod	30,sec
R5256	T8221	T8219	pobj	sec,for
R5257	T8222	T8217	punct	", ",°C
R5258	T8223	T8224	nummod	55,°C
R5259	T8224	T8217	appos	°C,°C
R5260	T8225	T8224	prep	for,°C
R5261	T8226	T8227	nummod	30,sec
R5262	T8227	T8225	pobj	sec,for
R5263	T8228	T8217	punct	", ",°C
R5264	T8229	T8230	nummod	72,°C
R5265	T8230	T8217	appos	°C,°C
R5266	T8231	T8230	prep	for,°C
R5267	T8232	T8233	nummod	30,sec
R5268	T8233	T8231	pobj	sec,for
R5269	T8234	T8217	punct	),°C
R5270	T8235	T8217	punct	×,°C
R5271	T8236	T8217	appos	32,°C
R5272	T8237	T8217	cc	and,°C
R5273	T8238	T8239	punct	(,°C
R5274	T8239	T8217	conj	°C,°C
R5275	T8240	T8239	nummod	72,°C
R5276	T8241	T8239	prep	for,°C
R5277	T8242	T8243	nummod	2,min
R5278	T8243	T8241	pobj	min,for
R5279	T8244	T8239	punct	),°C
R5280	T8245	T8239	punct	×,°C
R5281	T8246	T8239	appos	1,°C
R5282	T8247	T8205	punct	.,were
R5283	T8249	T8250	nsubjpass	Products,resolved
R5284	T8251	T8250	auxpass	were,resolved
R5285	T8252	T8250	prep	on,resolved
R5286	T8253	T8254	det	a,gel
R5287	T8254	T8252	pobj	gel,on
R5288	T8255	T8256	nummod	2.5,%
R5289	T8256	T8254	compound	%,gel
R5290	T8257	T8254	compound	agarose,gel
R5291	T8258	T8250	prep	with,resolved
R5292	T8259	T8260	compound	ΦX174,HaeIII
R5293	T8260	T8262	compound	HaeIII,markers
R5294	T8261	T8260	punct	/,HaeIII
R5295	T8262	T8258	pobj	markers,with
R5296	T8263	T8262	compound	size,markers
R5297	T8264	T8265	punct	(,Promega
R5298	T8265	T8262	parataxis	Promega,markers
R5299	T8266	T8265	punct	),Promega
R5300	T8267	T8250	punct	.,resolved
R5301	T8300	T8299	prep	of,Characterisation
R5302	T8301	T8302	det	the,peptide
R5303	T8302	T8300	pobj	peptide,of
R5304	T8303	T8302	nmod	PAX6,peptide
R5305	T8304	T8305	npadvmod	C,terminal
R5306	T8305	T8302	amod	terminal,peptide
R5307	T8306	T8305	punct	-,terminal
R5308	T8307	T8299	punct	.,Characterisation
R5309	T8309	T8310	punct	(,a
R5310	T8310	T8311	meta	a,alignment
R5311	T8312	T8310	punct	),a
R5312	T8313	T8311	compound	CLUSTAL,alignment
R5313	T8314	T8311	prep	of,alignment
R5314	T8315	T8316	det	the,acids
R5315	T8316	T8314	pobj	acids,of
R5316	T8317	T8316	amod	terminal,acids
R5317	T8318	T8316	nummod	42,acids
R5318	T8319	T8316	compound	amino,acids
R5319	T8320	T8316	prep	of,acids
R5320	T8321	T8320	pobj	PAX6,of
R5321	T8322	T8316	prep	from,acids
R5322	T8323	T8324	amod	diverse,species
R5323	T8324	T8322	pobj	species,from
R5324	T8325	T8311	punct	.,alignment
R5325	T8327	T8328	punct	(,indicates
R5326	T8328	T8331	ccomp	indicates,indicates
R5327	T8329	T8328	nsubj	*,indicates
R5328	T8330	T8328	punct	),indicates
R5329	T8332	T8333	amod	invariant,residues
R5330	T8333	T8328	dobj	residues,indicates
R5331	T8334	T8328	punct	", ",indicates
R5332	T8335	T8328	punct	(,indicates
R5333	T8336	T8331	nsubj	:,indicates
R5334	T8337	T8331	punct	),indicates
R5335	T8338	T8339	advmod	highly,similar
R5336	T8339	T8340	amod	similar,substitutions
R5337	T8340	T8331	dobj	substitutions,indicates
R5338	T8341	T8331	cc	and,indicates
R5339	T8342	T8343	punct	(,indicates
R5340	T8343	T8331	conj	indicates,indicates
R5341	T8344	T8343	nsubj	.,indicates
R5342	T8345	T8343	punct	),indicates
R5343	T8346	T8347	advmod	moderately,similar
R5344	T8347	T8348	amod	similar,substitutions
R5345	T8348	T8343	dobj	substitutions,indicates
R5346	T8349	T8343	punct	.,indicates
R5347	T8351	T8352	punct	(,b
R5348	T8352	T8353	meta	b,predicts
R5349	T8354	T8352	punct	),b
R5350	T8355	T8356	amod	Secondary,analysis
R5351	T8356	T8353	nsubj	analysis,predicts
R5352	T8357	T8356	compound	structure,analysis
R5353	T8358	T8356	prep	of,analysis
R5354	T8359	T8360	det	the,acids
R5355	T8360	T8358	pobj	acids,of
R5356	T8361	T8362	advmod	highly,conserved
R5357	T8362	T8360	amod	conserved,acids
R5358	T8363	T8360	amod	terminal,acids
R5359	T8364	T8360	nummod	28,acids
R5360	T8365	T8360	compound	amino,acids
R5361	T8366	T8367	det	a,sheet
R5362	T8367	T8353	dobj	sheet,predicts
R5363	T8368	T8367	amod	single,sheet
R5364	T8369	T8367	compound	beta,sheet
R5365	T8370	T8371	punct	(,arrow
R5366	T8371	T8367	parataxis	arrow,sheet
R5367	T8372	T8371	punct	),arrow
R5368	T8373	T8353	prep	in,predicts
R5369	T8374	T8375	det	the,peptide
R5370	T8375	T8373	pobj	peptide,in
R5371	T8376	T8375	compound	SVPVQ,peptide
R5372	T8377	T8353	punct	.,predicts
R5373	T8379	T8380	punct	(,c
R5374	T8380	T8381	meta	c,predicted
R5375	T8382	T8380	punct	),c
R5376	T8383	T8384	advmod	When,added
R5377	T8384	T8381	advcl	added,predicted
R5378	T8385	T8386	nummod	4,residues
R5379	T8386	T8384	nsubjpass	residues,added
R5380	T8387	T8384	auxpass	are,added
R5381	T8388	T8384	prep	in,added
R5382	T8389	T8390	det	the,direction
R5383	T8390	T8388	pobj	direction,in
R5384	T8391	T8392	npadvmod	N,terminal
R5385	T8392	T8390	amod	terminal,direction
R5386	T8393	T8392	punct	-,terminal
R5387	T8394	T8381	punct	", ",predicted
R5388	T8395	T8396	nummod	2,sheets
R5389	T8396	T8381	nsubjpass	sheets,predicted
R5390	T8397	T8396	compound	beta,sheets
R5391	T8398	T8381	auxpass	are,predicted
R5392	T8399	T8381	advmod	now,predicted
R5393	T8400	T8381	punct	.,predicted
R5394	T8468	T8469	amod	Semi-quantitative,analysis
R5395	T8470	T8469	compound	PCR,analysis
R5396	T8471	T8469	prep	of,analysis
R5397	T8472	T8471	pobj	Homer3,of
R5398	T8473	T8472	punct	", ",Homer3
R5399	T8474	T8472	conj	Dncl1,Homer3
R5400	T8475	T8474	punct	", ",Dncl1
R5401	T8476	T8474	conj	Trim11,Dncl1
R5402	T8477	T8476	cc	and,Trim11
R5403	T8478	T8476	conj	Pax6,Trim11
R5404	T8479	T8469	prep	in,analysis
R5405	T8480	T8481	det	the,library
R5406	T8481	T8479	pobj	library,in
R5407	T8482	T8483	compound	mouse,brain
R5408	T8483	T8481	compound	brain,library
R5409	T8484	T8481	compound	cDNA,library
R5410	T8485	T8469	punct	.,analysis
R5411	T8487	T8488	compound	Library,cDNA
R5412	T8488	T8489	nsubjpass	cDNA,amplified
R5413	T8490	T8489	auxpass	was,amplified
R5414	T8491	T8489	prep	with,amplified
R5415	T8492	T8491	pobj	primers,with
R5416	T8493	T8492	amod	specific,primers
R5417	T8494	T8493	prep	for,specific
R5418	T8495	T8494	pobj	Pax6,for
R5419	T8496	T8497	punct	(,bp
R5420	T8497	T8495	parataxis	bp,Pax6
R5421	T8498	T8497	nummod	600,bp
R5422	T8499	T8497	punct	),bp
R5423	T8500	T8495	punct	", ",Pax6
R5424	T8501	T8495	conj	Homer3,Pax6
R5425	T8502	T8503	punct	(,band
R5426	T8503	T8501	parataxis	band,Homer3
R5427	T8504	T8505	nummod	485,bp
R5428	T8505	T8503	compound	bp,band
R5429	T8506	T8503	punct	),band
R5430	T8507	T8501	punct	", ",Homer3
R5431	T8508	T8501	conj	Dncl1,Homer3
R5432	T8509	T8510	punct	(,bp
R5433	T8510	T8508	parataxis	bp,Dncl1
R5434	T8511	T8510	nummod	485,bp
R5435	T8512	T8510	punct	),bp
R5436	T8513	T8508	cc	and,Dncl1
R5437	T8514	T8508	conj	Trim11,Dncl1
R5438	T8515	T8516	punct	(,bp
R5439	T8516	T8514	parataxis	bp,Trim11
R5440	T8517	T8516	nummod	609,bp
R5441	T8518	T8516	punct	),bp
R5442	T8519	T8489	prep	for,amplified
R5443	T8520	T8521	nummod	20,cycles
R5444	T8521	T8519	pobj	cycles,for
R5445	T8522	T8520	punct	", ",20
R5446	T8523	T8520	conj	25,20
R5447	T8524	T8523	punct	", ",25
R5448	T8525	T8523	conj	30,25
R5449	T8526	T8525	cc	or,30
R5450	T8527	T8525	conj	35,30
R5451	T8528	T8489	punct	.,amplified
R5452	T8530	T8531	nsubjpass	Atp5a1,included
R5453	T8532	T8533	punct	(,bp
R5454	T8533	T8530	parataxis	bp,Atp5a1
R5455	T8534	T8533	nummod	415,bp
R5456	T8535	T8533	punct	),bp
R5457	T8536	T8530	cc	and,Atp5a1
R5458	T8537	T8530	conj	Gapdh,Atp5a1
R5459	T8538	T8539	punct	(,bp
R5460	T8539	T8537	parataxis	bp,Gapdh
R5461	T8540	T8539	nummod	450,bp
R5462	T8541	T8539	punct	),bp
R5463	T8542	T8530	punct	", ",Atp5a1
R5464	T8543	T8544	dep	which,expressed
R5465	T8544	T8530	relcl	expressed,Atp5a1
R5466	T8545	T8544	auxpass	are,expressed
R5467	T8546	T8544	advmod	highly,expressed
R5468	T8547	T8544	prep	in,expressed
R5469	T8548	T8549	det	the,brain
R5470	T8549	T8547	pobj	brain,in
R5471	T8550	T8531	punct	", ",included
R5472	T8551	T8531	auxpass	are,included
R5473	T8552	T8531	prep	for,included
R5474	T8553	T8552	pobj	comparison,for
R5475	T8554	T8531	punct	.,included
R5476	T8556	T8557	nsubj	M,indicates
R5477	T8557	T8558	ccomp	indicates,indicated
R5478	T8559	T8560	det	the,marker
R5479	T8560	T8557	dobj	marker,indicates
R5480	T8561	T8562	nmod	Φ×,HaeIII
R5481	T8562	T8560	compound	HaeIII,marker
R5482	T8563	T8562	nummod	174,HaeIII
R5483	T8564	T8565	compound	DNA,size
R5484	T8565	T8560	compound	size,marker
R5485	T8566	T8558	punct	;,indicated
R5486	T8567	T8568	det	the,positions
R5487	T8568	T8558	nsubjpass	positions,indicated
R5488	T8569	T8568	prep	of,positions
R5489	T8570	T8571	det	the,bands
R5490	T8571	T8569	pobj	bands,of
R5491	T8572	T8573	nummod	603,bp
R5492	T8573	T8571	nmod	bp,bands
R5493	T8574	T8573	cc	and,bp
R5494	T8575	T8576	nummod	310,bp
R5495	T8576	T8573	conj	bp,bp
R5496	T8577	T8571	compound	marker,bands
R5497	T8578	T8558	auxpass	are,indicated
R5498	T8579	T8558	punct	.,indicated
R5499	T8632	T8633	compound	LacZ,activation
R5500	T8634	T8635	compound	reporter,gene
R5501	T8635	T8633	compound	gene,activation
R5502	T8636	T8633	prep	in,activation
R5503	T8637	T8638	amod	pairwise,tests
R5504	T8638	T8636	pobj	tests,in
R5505	T8639	T8633	punct	.,activation
R5506	T8641	T8642	compound	pPC86,constructs
R5507	T8642	T8643	nsubjpass	constructs,shown
R5508	T8644	T8643	auxpass	are,shown
R5509	T8645	T8643	prep	across,shown
R5510	T8646	T8647	det	the,top
R5511	T8647	T8645	pobj	top,across
R5512	T8648	T8643	punct	", ",shown
R5513	T8649	T8643	cc	and,shown
R5514	T8650	T8651	compound	pDBLeu,constructs
R5515	T8651	T8652	nsubjpass	constructs,shown
R5516	T8652	T8643	conj	shown,shown
R5517	T8653	T8652	auxpass	are,shown
R5518	T8654	T8652	prep	down,shown
R5519	T8655	T8656	det	the,side
R5520	T8656	T8654	pobj	side,down
R5521	T8657	T8658	amod	right,hand
R5522	T8658	T8656	compound	hand,side
R5523	T8659	T8652	punct	.,shown
R5524	T8662	T8661	punct	", ",PAX6PST
R5525	T8663	T8664	compound	PAX6,domain
R5526	T8664	T8661	appos	domain,PAX6PST
R5527	T8665	T8664	compound	PST,domain
R5528	T8666	T8661	punct	;,PAX6PST
R5529	T8667	T8668	compound	PAX6PST,Q422R
R5530	T8668	T8661	appos	Q422R,PAX6PST
R5531	T8669	T8668	punct	/,Q422R
R5532	T8670	T8668	punct	", ",Q422R
R5533	T8671	T8672	compound	PAX6,domain
R5534	T8672	T8668	appos	domain,Q422R
R5535	T8673	T8672	compound	PST,domain
R5536	T8674	T8672	prep	with,domain
R5537	T8675	T8676	det	the,mutation
R5538	T8676	T8674	pobj	mutation,with
R5539	T8677	T8676	compound	Q422R,mutation
R5540	T8678	T8661	punct	;,PAX6PST
R5541	T8679	T8680	compound	PAX6PST,X423L
R5542	T8680	T8661	appos	X423L,PAX6PST
R5543	T8681	T8680	punct	/,X423L
R5544	T8682	T8680	punct	", ",X423L
R5545	T8683	T8684	compound	PAX6,domain
R5546	T8684	T8680	appos	domain,X423L
R5547	T8685	T8684	compound	PST,domain
R5548	T8686	T8684	prep	with,domain
R5549	T8687	T8688	det	the,mutation
R5550	T8688	T8686	pobj	mutation,with
R5551	T8689	T8688	compound	X423L,mutation
R5552	T8690	T8661	punct	", ",PAX6PST
R5553	T8691	T8692	compound	PAX6PST,1615del10
R5554	T8692	T8661	appos	1615del10,PAX6PST
R5555	T8693	T8692	punct	/,1615del10
R5556	T8694	T8692	punct	", ",1615del10
R5557	T8695	T8696	compound	PAX6,domain
R5558	T8696	T8692	appos	domain,1615del10
R5559	T8697	T8696	compound	PST,domain
R5560	T8698	T8696	prep	with,domain
R5561	T8699	T8700	det	the,mutation
R5562	T8700	T8698	pobj	mutation,with
R5563	T8701	T8700	nummod	1615,mutation
R5564	T8702	T8700	compound	del10,mutation
R5565	T8703	T8661	punct	;,PAX6PST
R5566	T8704	T8705	compound	PAX6PST,CT
R5567	T8705	T8661	appos	CT,PAX6PST
R5568	T8706	T8705	punct	-,CT
R5569	T8707	T8705	punct	", ",CT
R5570	T8708	T8709	compound	PAX6,PST
R5571	T8709	T8710	compound	PST,domain
R5572	T8710	T8705	appos	domain,CT
R5573	T8711	T8710	cc	minus,domain
R5574	T8712	T8713	det	the,peptide
R5575	T8713	T8710	conj	peptide,domain
R5576	T8714	T8715	npadvmod	C,terminal
R5577	T8715	T8713	amod	terminal,peptide
R5578	T8716	T8715	punct	-,terminal
R5579	T8717	T8661	punct	.,PAX6PST
R5580	T8719	T8720	punct	',is
R5581	T8721	T8722	amod	Truncated,HOMER3
R5582	T8722	T8720	nsubj	HOMER3,is
R5583	T8723	T8720	punct	',is
R5584	T8724	T8720	attr	HOMER3,is
R5585	T8725	T8724	acl	lacking,HOMER3
R5586	T8726	T8727	det	the,acids
R5587	T8727	T8725	dobj	acids,lacking
R5588	T8728	T8729	npadvmod	N,terminal
R5589	T8729	T8727	amod	terminal,acids
R5590	T8730	T8729	punct	-,terminal
R5591	T8731	T8727	nummod	70,acids
R5592	T8732	T8727	compound	amino,acids
R5593	T8733	T8720	punct	.,is
R5594	T8735	T8736	nummod	Five,strains
R5595	T8736	T8738	nsubjpass	strains,shown
R5596	T8737	T8736	compound	control,strains
R5597	T8739	T8738	auxpass	are,shown
R5598	T8740	T8738	prep	for,shown
R5599	T8741	T8740	pobj	comparison,for
R5600	T8742	T8743	punct	(,left
R5601	T8743	T8738	parataxis	left,shown
R5602	T8744	T8743	punct	),left
R5603	T8745	T8738	punct	.,shown
R5604	T8747	T8748	nsubj	These,range
R5605	T8749	T8748	prep	from,range
R5606	T8750	T8749	pobj	non-interactor,from
R5607	T8751	T8752	punct	(,A
R5608	T8752	T8750	parataxis	A,non-interactor
R5609	T8753	T8752	punct	),A
R5610	T8754	T8749	prep	to,from
R5611	T8755	T8756	amod	strong,interactor
R5612	T8756	T8754	pobj	interactor,to
R5613	T8757	T8758	punct	(,E
R5614	T8758	T8756	parataxis	E,interactor
R5615	T8759	T8758	punct	),E
R5616	T8760	T8748	punct	.,range
R5617	T8837	T8838	amod	Pairwise,tests
R5618	T8839	T8838	compound	interaction,tests
R5619	T8840	T8838	prep	between,tests
R5620	T8841	T8842	amod	normal,constructs
R5621	T8842	T8840	pobj	constructs,between
R5622	T8843	T8841	cc	and,normal
R5623	T8844	T8841	conj	mutant,normal
R5624	T8845	T8842	compound	PAX6,constructs
R5625	T8846	T8842	cc	and,constructs
R5626	T8847	T8842	conj	HOMER3,constructs
R5627	T8848	T8847	punct	", ",HOMER3
R5628	T8849	T8847	conj	DNCL1,HOMER3
R5629	T8850	T8849	cc	and,DNCL1
R5630	T8851	T8849	conj	TRIM11,DNCL1
R5631	T8852	T8838	punct	.,tests
R5632	T8855	T8854	punct	: ,+++
R5633	T8856	T8857	amod	strong,interaction
R5634	T8857	T8854	appos	interaction,+++
R5635	T8858	T8854	punct	;,+++
R5636	T8859	T8854	appos	++,+++
R5637	T8860	T8859	punct	: ,++
R5638	T8861	T8862	amod	moderate,interaction
R5639	T8862	T8859	appos	interaction,++
R5640	T8863	T8854	punct	;,+++
R5641	T8864	T8854	appos	+,+++
R5642	T8865	T8864	punct	: ,+
R5643	T8866	T8867	amod	weak,interaction
R5644	T8867	T8864	appos	interaction,+
R5645	T8868	T8854	punct	;,+++
R5646	T8869	T8870	punct	(,)
R5647	T8870	T8854	appos	),+++
R5648	T8871	T8870	punct	+,)
R5649	T8872	T8873	amod	borderline,interaction
R5650	T8873	T8870	appos	interaction,)
R5651	T8874	T8873	prep	with,interaction
R5652	T8875	T8876	nummod	one,reporters
R5653	T8876	T8874	pobj	reporters,with
R5654	T8877	T8875	cc	or,one
R5655	T8878	T8875	conj	two,one
R5656	T8879	T8876	acl	activated,reporters
R5657	T8880	T8879	prep	at,activated
R5658	T8881	T8882	advmod	very,low
R5659	T8882	T8883	amod	low,levels
R5660	T8883	T8880	pobj	levels,at
R5661	T8884	T8854	punct	;,+++
R5662	T8885	T8854	appos	0,+++
R5663	T8886	T8885	punct	: ,0
R5664	T8887	T8888	det	no,interaction
R5665	T8888	T8885	appos	interaction,0
R5666	T8889	T8854	punct	.,+++
R5667	T8892	T8891	punct	", ",PAX6PST
R5668	T8893	T8894	compound	PAX6,domain
R5669	T8894	T8891	appos	domain,PAX6PST
R5670	T8895	T8894	compound	PST,domain
R5671	T8896	T8891	punct	;,PAX6PST
R5672	T8897	T8891	appos	PAX6CTP,PAX6PST
R5673	T8898	T8897	punct	", ",PAX6CTP
R5674	T8899	T8900	nmod	PAX6,peptide
R5675	T8900	T8897	appos	peptide,PAX6CTP
R5676	T8901	T8902	npadvmod	C,terminal
R5677	T8902	T8900	amod	terminal,peptide
R5678	T8903	T8902	punct	-,terminal
R5679	T8904	T8891	punct	;,PAX6PST
R5680	T8905	T8906	compound	PAX6PST,CT
R5681	T8906	T8891	appos	CT,PAX6PST
R5682	T8907	T8906	punct	-,CT
R5683	T8908	T8906	punct	", ",CT
R5684	T8909	T8910	compound	PAX6,domain
R5685	T8910	T8906	appos	domain,CT
R5686	T8911	T8910	compound	PST,domain
R5687	T8912	T8910	cc	minus,domain
R5688	T8913	T8914	det	the,peptide
R5689	T8914	T8910	conj	peptide,domain
R5690	T8915	T8916	npadvmod	C,terminal
R5691	T8916	T8914	amod	terminal,peptide
R5692	T8917	T8916	punct	-,terminal
R5693	T8918	T8891	punct	;,PAX6PST
R5694	T8919	T8920	compound	PAX6PST,Q422R
R5695	T8920	T8891	appos	Q422R,PAX6PST
R5696	T8921	T8920	punct	/,Q422R
R5697	T8922	T8920	punct	", ",Q422R
R5698	T8923	T8924	compound	PAX6,domain
R5699	T8924	T8920	appos	domain,Q422R
R5700	T8925	T8924	compound	PST,domain
R5701	T8926	T8924	prep	with,domain
R5702	T8927	T8928	det	the,mutation
R5703	T8928	T8926	pobj	mutation,with
R5704	T8929	T8928	compound	Q422R,mutation
R5705	T8930	T8891	punct	;,PAX6PST
R5706	T8931	T8932	compound	PAX6PST,X423L
R5707	T8932	T8891	appos	X423L,PAX6PST
R5708	T8933	T8932	punct	/,X423L
R5709	T8934	T8932	punct	", ",X423L
R5710	T8935	T8936	compound	PAX6,domain
R5711	T8936	T8932	appos	domain,X423L
R5712	T8937	T8936	compound	PST,domain
R5713	T8938	T8936	prep	with,domain
R5714	T8939	T8940	det	the,mutation
R5715	T8940	T8938	pobj	mutation,with
R5716	T8941	T8940	compound	X423L,mutation
R5717	T8942	T8891	punct	", ",PAX6PST
R5718	T8943	T8944	compound	PAX6PST,1615del
R5719	T8944	T8891	appos	1615del,PAX6PST
R5720	T8945	T8944	punct	/,1615del
R5721	T8946	T8944	punct	", ",1615del
R5722	T8947	T8948	compound	PAX6,domain
R5723	T8948	T8944	appos	domain,1615del
R5724	T8949	T8948	compound	PST,domain
R5725	T8950	T8948	prep	with,domain
R5726	T8951	T8952	det	the,mutation
R5727	T8952	T8950	pobj	mutation,with
R5728	T8953	T8952	nummod	1615,mutation
R5729	T8954	T8952	compound	del10,mutation
R5730	T8955	T8891	punct	.,PAX6PST
R5731	T8957	T8958	compound	HOMER3,FL
R5732	T8959	T8958	punct	-,FL
R5733	T8960	T8958	punct	", ",FL
R5734	T8961	T8962	nmod	HOMER3,clone
R5735	T8962	T8958	appos	clone,FL
R5736	T8963	T8964	amod	full,length
R5737	T8964	T8962	compound	length,clone
R5738	T8965	T8964	punct	-,length
R5739	T8966	T8958	punct	;,FL
R5740	T8967	T8968	compound	HOMER3,Tr
R5741	T8968	T8958	appos	Tr,FL
R5742	T8969	T8968	punct	-,Tr
R5743	T8970	T8968	punct	", ",Tr
R5744	T8971	T8972	amod	truncated,clone
R5745	T8972	T8968	appos	clone,Tr
R5746	T8973	T8972	compound	HOMER3,clone
R5747	T8974	T8972	acl	lacking,clone
R5748	T8975	T8976	det	the,acids
R5749	T8976	T8974	dobj	acids,lacking
R5750	T8977	T8978	npadvmod	N,terminal
R5751	T8978	T8976	amod	terminal,acids
R5752	T8979	T8978	punct	-,terminal
R5753	T8980	T8976	nummod	70,acids
R5754	T8981	T8976	compound	amino,acids
R5755	T8982	T8958	punct	.,FL
R1815	T2914	T2911	punct	],30
R1816	T2915	T2895	punct	.,show
R1817	T2917	T2918	nsubjpass	Homer3,amplified
R1818	T2919	T2917	punct	", ",Homer3
R1819	T2920	T2917	conj	Dncl1,Homer3
R1820	T2921	T2920	punct	", ",Dncl1
R1821	T2922	T2920	conj	Trim11,Dncl1
R1822	T2923	T2922	cc	and,Trim11
R1823	T2924	T2922	conj	Pax6,Trim11
R1824	T2925	T2918	auxpass	were,amplified
R1825	T2926	T2918	advmod	only,amplified
R1826	T2927	T2918	advmod	strongly,amplified
R1827	T2928	T2918	prep	after,amplified
R1828	T2929	T2930	nummod	35,cycles
R1829	T2930	T2928	pobj	cycles,after
R1830	T2931	T2930	prep	of,cycles
R1831	T2932	T2931	pobj	PCR,of
R1832	T2933	T2934	punct	(,Figure
R1833	T2934	T2918	parataxis	Figure,amplified
R1834	T2935	T2934	nummod	2,Figure
R1835	T2936	T2934	punct	),Figure
R1836	T2937	T2918	cc	and,amplified
R1837	T2938	T2918	conj	were,amplified
R1838	T2939	T2938	advmod	therefore,were
R1839	T2940	T2938	acomp	present,were
R1840	T2941	T2940	prep	at,present
R1841	T2942	T2943	advmod	relatively,low
R1842	T2943	T2944	amod	low,levels
R1843	T2944	T2941	pobj	levels,at
R1867	T2969	T2970	nsubj	We,concluded
R1868	T2971	T2972	mark	that,were
R1870	T2973	T2974	nmod	Homer3,clones
R1872	T2975	T2973	punct	", ",Homer3
R1069	T1819	T1815	punct	),278
R1070	T1820	T1821	det	a,motif
R1071	T1821	T1803	dobj	motif,revealed
R1072	T1822	T1823	advmod	highly,conserved
R1073	T1823	T1821	amod	conserved,motif
R1074	T1824	T1821	prep	within,motif
R1075	T1825	T1826	det	the,acids
R1076	T1826	T1824	pobj	acids,within
R1077	T1827	T1826	amod	last,acids
R1078	T1828	T1826	nummod	28,acids
R1079	T1829	T1826	compound	amino,acids
R1080	T1830	T1821	punct	(,motif
R1081	T1831	T1821	acl	beginning,motif
R1082	T1832	T1831	prep	at,beginning
R1083	T1833	T1834	det	the,motif
R1084	T1834	T1832	pobj	motif,at
R1085	T1835	T1834	punct	',motif
R1086	T1836	T1834	nmod	GLISP,motif
R1087	T1837	T1834	punct	',motif
R1088	T1838	T1839	punct	", ",Figure
R1089	T1839	T1803	parataxis	Figure,revealed
R1090	T1840	T1839	nummod	1a,Figure
R1091	T1841	T1839	punct	),Figure
R1092	T1842	T1803	punct	.,revealed
R1093	T1844	T1845	amod	Strong,conservation
R1094	T1845	T1846	nsubjpass	conservation,seen
R1095	T1847	T1846	auxpass	was,seen
R1096	T1848	T1846	prep	in,seen
R1097	T1849	T1850	advmod	distantly,related
R1098	T1850	T1851	amod	related,species
R1099	T1851	T1848	pobj	species,in
R1119	T1872	T1873	nsubj	We,subjected
R1120	T1874	T1875	det	the,domain
R1121	T1875	T1873	dobj	domain,subjected
R1122	T1876	T1875	amod	whole,domain
R1123	T1877	T1875	compound	PAX6,domain
R1124	T1878	T1875	compound	PST,domain
R1125	T1879	T1873	prep	to,subjected
R1126	T1880	T1881	amod	secondary,analysis
R1127	T1881	T1879	pobj	analysis,to
R1128	T1882	T1881	compound	structure,analysis
R1129	T1883	T1873	advcl	using,subjected
R1130	T1884	T1883	dobj	JPRED,using
R1131	T1885	T1884	punct	", ",JPRED
R1132	T1886	T1887	det	a,program
R1133	T1887	T1884	appos	program,JPRED
R1134	T1888	T1889	dep	that,uses
R1135	T1889	T1887	relcl	uses,program
R1136	T1890	T1891	det	a,number
R2314	T3812	T3769	punct	.,is
R2315	T3818	T3819	nummod	v,in
R2316	T3829	T3830	advcl	ed,investigated
R2317	T3831	T3832	mark	that,interact
R2318	T3832	T3829	ccomp	interact,ed
R2319	T3833	T3832	nsubj	HOMER3,interact
R2320	T3834	T3833	punct	", ",HOMER3
R2321	T3835	T3833	conj	DNCL1,HOMER3
R2322	T3836	T3835	cc	and,DNCL1
R2323	T3837	T3835	conj	TRIM11,DNCL1
R2324	T3838	T3832	prep	with,interact
R2325	T3839	T3840	det	the,domain
R2326	T3840	T3838	pobj	domain,with
R2327	T3841	T3840	compound	PAX6,domain
R2328	T3842	T3840	compound	PST,domain
R2329	T3843	T3830	punct	", ",investigated
R2330	T3844	T3830	nsubj	we,investigated
R2331	T3845	T3830	advmod	next,investigated
R2332	T3846	T3847	advmod	how,affected
R2333	T3847	T3830	ccomp	affected,investigated
R3986	T6386	T6384	pobj	effect,from
R3988	T6387	T6386	amod	specific,effect
R3989	T6388	T6386	prep	of,effect
R3991	T6389	T6390	det	these,mutations
R3992	T6390	T6388	pobj	mutations,of
R3994	T6391	T6390	amod	unusual,mutations
R3995	T6392	T6393	npadvmod	C,terminal
R3997	T6393	T6390	amod	terminal,mutations
R3998	T6394	T6393	punct	-,terminal
R4000	T6395	T6390	compound	extension,mutations
R4001	T6396	T6373	punct	.,result
R4003	T6398	T6399	expl	There,is
R4004	T6400	T6399	attr	evidence,is
R4006	T6401	T6402	mark	that,conserved
R4007	T6402	T6400	acl	conserved,evidence
R4009	T6403	T6404	nmod	signalling,mechanisms
R4010	T6404	T6402	nsubjpass	mechanisms,conserved
R4011	T6405	T6403	cc	and,signalling
R4013	T6406	T6403	conj	transport,signalling
R4014	T6407	T6408	dep	that,characterized

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T7961	29509-29516	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T7960	29491-29496	NCBITaxon:1910954	denotes	ΦX174
T7959	29474-29481	CHEBI:2511	denotes	agarose
T7958	29288-29298	GO_EXT:polymerase	denotes	polymerase
T7957	29255-29261	SO_EXT:0000112	denotes	primer
T7956	29237-29242	CHEBI:6636	denotes	MgCl2
T7955	29207-29213	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T7954	29196-29206	GO_EXT:polymerase	denotes	polymerase
T7953	29140-29144	SO_EXT:cDNA	denotes	cDNA
T7952	29096-29097	SO:0001031	denotes	R
T7951	29089-29095	PR_EXT:000004453	denotes	Atp5a1
T7950	29058-29059	SO:0001030	denotes	F
T7949	29051-29057	PR_EXT:000004453	denotes	Atp5a1
T7948	29020-29021	SO:0001031	denotes	R
T7947	29014-29019	GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase	denotes	Gapdh
T7946	28983-28984	SO:0001030	denotes	F
T7945	28977-28982	GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase	denotes	Gapdh
T7944	28946-28947	SO:0001031	denotes	R
T7943	28940-28945	PR_EXT:000002325	denotes	Dncl1
T7942	28911-28912	SO:0001030	denotes	F
T7941	28905-28910	PR_EXT:000002325	denotes	Dncl1
T7940	28875-28876	SO:0001031	denotes	R
T7939	28868-28874	PR_EXT:000016642	denotes	Trim11
T7938	28841-28842	SO:0001030	denotes	F
T7937	28834-28840	PR_EXT:000016642	denotes	Trim11
T7936	28801-28802	SO:0001031	denotes	R
T7935	28794-28800	PR_EXT:000008680	denotes	Homer3
T7934	28767-28768	SO:0001030	denotes	F
T7933	28760-28766	PR_EXT:000008680	denotes	Homer3
T7932	28730-28731	SO:0001031	denotes	R
T7931	28725-28729	PR_EXT:000012318	denotes	Pax6
T7930	28694-28695	SO:0001030	denotes	F
T7929	28689-28693	PR_EXT:000012318	denotes	Pax6
T7928	28673-28682	SO_EXT:biological_sequence	denotes	sequences
T7927	28666-28672	SO_EXT:0000112	denotes	Primer
T7926	28643-28649	SO_EXT:sequence_cloned_entity	denotes	clones
T7925	28635-28642	GO:0008380	denotes	spliced
T7924	28604-28610	SO_EXT:0000188	denotes	intron
T7923	28560-28567	SO_EXT:0000112	denotes	Primers
T7922	28544-28550	PR_EXT:000004453	denotes	Atp5a1
T7921	28534-28539	GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase	denotes	Gapdh
T7920	28528-28533	SO_EXT:0000704	denotes	genes
T7918	28488-28494	PR_EXT:000016642	denotes	Trim11
T7917	28481-28486	PR_EXT:000002325	denotes	Dncl1
T7916	28473-28479	PR_EXT:000008680	denotes	Homer3
T7710	28326-28335	SO_EXT:engineered_biological_sequence	denotes	construct
T7709	28315-28325	GO:0010467	denotes	expression
T7708	28283-28290	SO_EXT:0000155	denotes	plasmid
T7707	28276-28282	PR_EXT:000008680	denotes	Homer3
T7706	28252-28260	SO_EXT:sequence_insertion_process	denotes	inserted
T7705	28235-28240	SO_EXT:sequence_cloned_entity	denotes	clone
T7704	28097-28105	SO_EXT:biological_sequence	denotes	sequence
T7703	28086-28096	CHEBI_SO_EXT:nucleotide	denotes	nucleotide
T7702	28082-28085	SO_EXT:0000345	denotes	EST
T7701	28030-28041	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T7700	28016-28026	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T7699	27951-27956	SO_EXT:sequence_cloned_entity	denotes	clone
T7698	27933-27943	SO_EXT:0000317	denotes	cDNA clone
T7697	27905-27910	SO_EXT:sequence_cloned_entity	denotes	clone
T7696	27898-27904	PR_EXT:000008680	denotes	Homer3
T7695	27848-27852	PR_EXT:000033987	denotes	LacZ
T7694	27839-27843	PR_EXT:P03962	denotes	URA3
T7693	27833-27837	PR_EXT:P06633	denotes	HIS3
T7692	27755-27764	SO_EXT:engineered_biological_sequence	denotes	construct
T7691	27720-27729	SO_EXT:engineered_biological_sequence	denotes	construct
T7690	27700-27705	CL_GO_EXT:cell	denotes	cells
T7689	27694-27699	NCBITaxon_EXT:yeast	denotes	yeast
T7688	27664-27676	GO:0009294	denotes	transforming
T7367	27591-27597	SO_EXT:0000667	denotes	insert
T7366	27586-27590	SO_EXT:cDNA	denotes	cDNA
T7365	27522-27528	SO_EXT:0000667	denotes	insert
T7364	27517-27521	SO_EXT:cDNA	denotes	cDNA
T7363	27494-27498	PR_EXT:000033987	denotes	LacZ
T7362	27489-27493	PR_EXT:P03962	denotes	URA3
T7361	27484-27488	PR_EXT:P06633	denotes	HIS3
T7360	27454-27461	SO_EXT:0000155	denotes	plasmid
T7359	27385-27389	PR_EXT:P06633	denotes	HIS3
T7358	27368-27372	PR_EXT:P06633	denotes	HIS3
T7357	27345-27354	CHEBI_SO_EXT:histidine	denotes	histidine
T7356	27291-27304	GO_EXT:transfectant_or_tranformant	denotes	Transformants
T7355	27249-27256	SO_EXT:0000155	denotes	plasmid
T7354	27223-27227	SO_EXT:cDNA	denotes	cDNA
T7353	27202-27213	GO:0009294	denotes	transformed
T7352	27188-27193	CL_GO_EXT:cell	denotes	cells
T7351	27182-27187	NCBITaxon_EXT:yeast	denotes	yeast
T7350	27154-27164	CHEBI_EXT:chemical_substance_or_polyatomic_entity	denotes	chemically
T7349	26993-26998	NCBITaxon_EXT:yeast	denotes	yeast
T7348	26896-26914	GO_EXT:0004565	denotes	beta-galactosidase
T7347	26872-26877	CHEBI:75055	denotes	X-gal
T7346	26849-26853	PR_EXT:000033987	denotes	LacZ
T7345	26841-26847	CHEBI_EXT:uracil_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group	denotes	uracil
T7344	26816-26822	GO_EXT:biological_growth_entity_or_process	denotes	growth
T7343	26792-26796	PR_EXT:P03962	denotes	URA3
T7342	26759-26778	CHEBI:74498	denotes	5-fluro-orotic acid
T7341	26731-26737	GO_EXT:biological_growth_entity_or_process	denotes	growth
T7340	26704-26708	PR_EXT:P03962	denotes	URA3
T7339	26688-26697	CHEBI_SO_EXT:histidine	denotes	histidine
T7338	26663-26669	GO_EXT:biological_growth_entity_or_process	denotes	growth
T7337	26640-26644	PR_EXT:P06633	denotes	HIS3
T7336	26625-26629	PR_EXT:P04386	denotes	GAL4
T7335	26589-26595	SO_EXT:0000417	denotes	domain
T7334	26573-26577	PR_EXT:P04386	denotes	GAL4
T7333	26560-26565	SO_EXT:sequence_fusion_process	denotes	fused
T7332	26552-26559	CHEBI_PR_EXT:protein	denotes	protein
T7331	26512-26518	SO_EXT:0000417	denotes	domain
T7330	26504-26511	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T7329	26500-26503	CHEBI_SO_EXT:DNA	denotes	DNA
T7328	26495-26499	PR_EXT:P04386	denotes	GAL4
T7327	26482-26487	SO_EXT:sequence_fusion_process	denotes	fused
T7326	26474-26481	CHEBI_PR_EXT:protein	denotes	protein
T7325	26395-26399	PR_EXT:000033987	denotes	lacZ
T7324	26386-26390	PR_EXT:P03962	denotes	URA3
T7323	26380-26384	PR_EXT:P06633	denotes	HIS3
T7322	26373-26378	SO_EXT:0000704	denotes	genes
T7321	26349-26353	PR_EXT:P04386	denotes	GAL4
T7320	26319-26325	SO_EXT:0000417	denotes	domain
T7319	26303-26307	PR_EXT:P04386	denotes	GAL4
T7318	26297-26302	NCBITaxon_EXT:yeast	denotes	yeast
T7317	26284-26289	SO_EXT:sequence_fusion_process	denotes	fused
T7316	26275-26283	CHEBI_PR_EXT:protein	denotes	proteins
T7315	26252-26258	SO_EXT:0000440	denotes	vector
T7314	26199-26209	SO_EXT:engineered_biological_sequence	denotes	constructs
T7313	26114-26118	SO_EXT:cDNA	denotes	cDNA
T7312	26108-26113	UBERON:0000955	denotes	brain
T7311	26102-26107	NCBITaxon:10088	denotes	mouse
T7310	26067-26072	NCBITaxon_EXT:yeast	denotes	Yeast
T6594	24155-24164	SO:0000993	denotes	consensus
T6593	24056-24060	PR_EXT:000012318	denotes	PAX6
T6592	24050-24055	NCBITaxon:9606	denotes	human
T6591	24036-24046	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminus
T6590	24018-24028	SO:0000857	denotes	homologous
T6589	23991-24000	SO_EXT:biological_sequence	denotes	sequences
T6588	23983-23990	CHEBI_PR_EXT:protein	denotes	Protein
T6587	23805-23813	SO_EXT:biological_sequence	denotes	Sequence
T6807	26056-26064	SO_EXT:sequence_insertion_process	denotes	inserted
T6806	26043-26051	SO_EXT:biological_sequence	denotes	sequence
T6805	26036-26042	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T6804	26019-26026	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T6803	26008-26018	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T6802	25989-25996	GO_EXT:biological_release	denotes	release
T6801	25963-25966	MOP:0000780	denotes	cut
T6800	25949-25958	SO_EXT:engineered_biological_sequence	denotes	construct
T6799	25884-25885	SO:0001031	denotes	R
T6798	25838-25839	SO:0001030	denotes	F
T6797	25818-25825	SO_EXT:0000112	denotes	Primers
T6796	25758-25761	CHEBI_SO_EXT:RNA	denotes	RNA
T6795	25738-25757	GO:0001171	denotes	reverse transcribed
T6794	25660-25669	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T6793	25635-25644	SO_EXT:biological_sequence	denotes	sequences
T6792	25630-25634	SO_EXT:cDNA	denotes	cDNA
T6791	25603-25615	SO_EXT:sequence_substitution_entity_or_process	denotes	substitution
T6790	25592-25602	CHEBI_SO_EXT:nucleotide	denotes	nucleotide
T6789	25585-25591	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T6788	25491-25497	SO_EXT:0000132	denotes	primer
T6787	25479-25486	_FRAGMENT	denotes	reverse
T6786	25454-25463	SO_EXT:engineered_biological_sequence	denotes	construct
T6785	25399-25400	CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group	denotes	G
T6784	25384-25392	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T6783	25359-25368	SO_EXT:engineered_biological_sequence	denotes	construct
T6782	25352-25358	SO_EXT:0000417	denotes	domain
T6781	25343-25347	PR_EXT:000012318	denotes	PAX6
T6780	25215-25232	SO_EXT:0000061	denotes	restriction sites
T6779	25170-25179	SO_EXT:sequence_insertion_process	denotes	inserting
T6778	25157-25164	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T6777	25146-25156	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T6776	25095-25102	MOP:0000780	denotes	cutting
T6775	25059-25066	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T6774	25048-25058	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T6773	25031-25037	SO_EXT:0000417	denotes	domain
T6772	24999-25000	SO:0001031	denotes	R
T6771	24936-24937	SO:0001030	denotes	F
T6770	24916-24923	SO_EXT:0000112	denotes	Primers
T6769	24891-24898	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T6768	24880-24890	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T6767	24787-24788	SO:0001031	denotes	R
T6766	24719-24726	SO:0001030	denotes	forward
T6765	24699-24706	SO_EXT:0000112	denotes	Primers
T6764	24689-24696	CHEBI_PR_EXT:protein	denotes	protein
T6763	24684-24688	PR_EXT:000012318	denotes	PAX6
T6762	24645-24656	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T6761	24637-24643	SO_EXT:0000417	denotes	domain
T6760	24598-24604	SO_EXT:0000417	denotes	domain
T6759	24590-24597	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T6758	24586-24589	CHEBI_SO_EXT:DNA	denotes	DNA
T6757	24581-24585	PR_EXT:P04386	denotes	GAL4
T6756	24575-24580	NCBITaxon_EXT:yeast	denotes	yeast
T6755	24562-24567	SO_EXT:sequence_fusion_process	denotes	fused
T6754	24554-24561	CHEBI_PR_EXT:protein	denotes	protein
T6753	24487-24493	SO_EXT:0000440	denotes	vector
T6752	24476-24486	GO:0010467	denotes	expression
T6751	24451-24461	SO_EXT:engineered_biological_sequence	denotes	constructs
T6750	24446-24450	SO_EXT:cDNA	denotes	cDNA
T6749	24441-24445	PR_EXT:000012318	denotes	PAX6
T6748	24346-24353	SO_EXT:sequence_variant_or_variation	denotes	Variant
T6747	24338-24345	SO_EXT:0001023	denotes	Allelic
T6746	24333-24337	PR_EXT:000012318	denotes	PAX6
T6745	24327-24332	NCBITaxon:9606	denotes	Human
T6744	24298-24307	SO_EXT:biological_sequence	denotes	sequences
T6743	24280-24287	CHEBI_PR_EXT:protein	denotes	protein
T6742	24271-24275	SO_EXT:cDNA	denotes	cDNA
T6741	24266-24270	PR_EXT:000012318	denotes	PAX6
T6740	24260-24265	NCBITaxon:9606	denotes	human
T6739	24223-24233	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T6738	24214-24218	SO_EXT:cDNA	denotes	cDNA
T6737	24199-24209	SO_EXT:engineered_biological_sequence	denotes	constructs
T6736	24182-24187	NCBITaxon_EXT:yeast	denotes	Yeast
T6503	23747-23754	CHEBI_PR_EXT:protein	denotes	protein
T6502	23739-23746	CHEBI_PR_EXT:protein	denotes	protein
T6501	23700-23709	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T6500	23695-23699	PR_EXT:000012318	denotes	PAX6
T6499	23661-23667	UBERON_EXT:neural_tissue_or_nerve_or_nervous_system	denotes	neural
T6498	23619-23626	CL:0000540	denotes	neurons
T6497	23600-23615	GO:0010467	denotes	gene expression
T6496	23600-23604	SO_EXT:0000704	denotes	gene
T6495	23579-23588	GO:0065007	denotes	regulated
T6494	23545-23564	GO:0099536	denotes	synaptic signalling
T6493	23545-23553	GO:0045202	denotes	synaptic
T6492	23515-23520	PR_EXT:000002325	denotes	DNCL1
T6491	23504-23510	PR_EXT:000008680	denotes	HOMER3
T6490	23494-23498	PR_EXT:000012318	denotes	PAX6
T6489	23451-23457	PR_EXT:000016642	denotes	TRIM11
T6488	23441-23446	PR_EXT:000002325	denotes	DNCL1
T6487	23433-23439	PR_EXT:000008680	denotes	HOMER3
T6486	23413-23417	PR_EXT:000012318	denotes	PAX6
T6485	23403-23412	GO_EXT:regulator	denotes	regulator
T6484	23387-23402	GO_EXT:transcription	denotes	transcriptional
T6483	23368-23386	GO:0007399	denotes	neurodevelopmental
T5072	23175-23182	CHEBI_PR_EXT:protein	denotes	protein
T5071	23170-23174	PR_EXT:000012318	denotes	PAX6
T5070	23137-23143	UBERON:0000966	denotes	retina
T5069	23120-23129	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T5068	23102-23107	UBERON:0000955	denotes	brain
T5067	23040-23049	GO_EXT:biological_routing_or_transport	denotes	transport
T5066	23025-23035	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signalling
T5003	21127-21132	NCBITaxon:9606	denotes	human
T5002	21117-21119	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T5001	21107-21113	PR_EXT:000016642	denotes	TRIM11
T5000	21097-21102	PR_EXT:000002325	denotes	DNCL1
T4999	21089-21095	PR_EXT:000008680	denotes	HOMER3
T4998	21083-21087	PR_EXT:000012318	denotes	PAX6
T4997	21069-21079	GO:0010467	denotes	expression
T4996	21029-21035	UBERON:0000479	denotes	tissue
T4995	21017-21021	PR_EXT:000012318	denotes	PAX6
T4994	20967-20977	GO:0010467	denotes	expression
T4993	20907-20917	GO:0010467	denotes	expression
T4992	20885-20891	PR_EXT:000016642	denotes	TRIM11
T4991	20875-20880	PR_EXT:000002325	denotes	DNCL1
T4990	20858-20868	UBERON:0002037	denotes	cerebellum
T4989	20842-20853	UBERON_EXT:hippocampus_proper_or_hippocampal_formation	denotes	hippocampus
T4988	20831-20840	UBERON:0001890	denotes	forebrain
T4987	20800-20805	UBERON:0000955	denotes	brain
T4986	20761-20765	UBERON:0002048	denotes	lung
T4985	20750-20756	UBERON:0002370	denotes	thymus
T4984	20718-20728	GO:0010467	denotes	expression
T4983	20711-20717	PR_EXT:000008680	denotes	HOMER3
T4982	20697-20703	UBERON:0000479	denotes	tissue
T4981	20683-20688	PR_EXT:000002325	denotes	DNCL1
T4980	20672-20678	PR_EXT:000016642	denotes	TRIM11
T4979	20647-20651	PR_EXT:000012318	denotes	PAX6
T4978	20639-20646	GO:0005634	denotes	nuclear
T4977	20623-20631	CHEBI_PR_EXT:protein	denotes	proteins
T4976	20576-20580	PR_EXT:000012318	denotes	PAX6
T4975	20564-20575	GO:0005737	denotes	cytoplasmic
T4974	20536-20547	GO:0005737	denotes	cytoplasmic
T4973	20524-20531	GO:0005634	denotes	nuclear
T4972	20509-20515	PR_EXT:000016642	denotes	TRIM11
T4971	20468-20480	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localisation
T4970	20460-20467	GO:0005634	denotes	nuclear
T4969	20438-20449	GO:0005737	denotes	cytoplasmic
T4968	20421-20426	PR_EXT:000002325	denotes	DNCL1
T4967	20405-20414	GO:0005737	denotes	cytoplasm
T4966	20393-20396	GO:0014069	denotes	PSD
T4965	20334-20340	PR_EXT:000008680	denotes	HOMER3
T4964	20324-20332	CHEBI_PR_EXT:protein	denotes	proteins
T4963	20283-20295	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localisation
T4962	20274-20282	CL_GO_EXT:cell	denotes	cellular
T4961	20271-20282	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T4960	20224-20227	GO:0014069	denotes	PSD
T4959	20167-20175	CL:0000540	denotes	neurones
T4958	20151-20163	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localisation
T4957	20142-20150	CL_GO_EXT:cell	denotes	cellular
T4956	20139-20150	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T4955	20115-20120	UBERON:0000955	denotes	brain
T4954	20081-20088	SO_EXT:0001060	denotes	isoform
T4953	20060-20064	NCBITaxon:10088	denotes	mice
T4952	20014-20017	CHEBI_SO_EXT:DNA	denotes	DNA
T4951	20008-20013	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T4950	19991-20002	GO:0005737	denotes	cytoplasmic
T4949	19979-19986	GO:0005634	denotes	nuclear
T4948	19963-19969	SO_EXT:0000417	denotes	domain
T4947	19933-19940	SO_EXT:0001060	denotes	isoform
T4946	19917-19925	NCBITaxon:6231	denotes	nematode
T4945	19907-19912	NCBITaxon_EXT:quail	denotes	quail
T4944	19900-19905	NCBITaxon:10088	denotes	mouse
T4943	19865-19872	GO:0005634	denotes	nuclear
T4942	19840-19847	CHEBI_PR_EXT:protein	denotes	protein
T4941	19835-19839	PR_EXT:000012318	denotes	PAX6
T4940	19793-19800	GO:0005634	denotes	nucleus
T4939	19777-19784	GO:0045202	denotes	synapse
T4938	19754-19764	CHEBI_EXT:33280	denotes	messengers
T4937	19735-19739	PR_EXT:CREB	denotes	CREB
T4936	19725-19730	PR_EXT:000002089	denotes	STAT3
T4935	19695-19716	GO:0014069	denotes	post-synaptic density
T4934	19664-19685	GO_EXT:transcription_factor	denotes	transcription factors
T4933	19664-19677	GO_EXT:transcription	denotes	transcription
T4932	19616-19623	CHEBI_PR_EXT:protein	denotes	protein
T4931	19611-19615	PR_EXT:000012318	denotes	PAX6
T4930	19563-19582	GO:0030163	denotes	protein degradation
T4929	19563-19570	CHEBI_PR_EXT:protein	denotes	protein
T4928	19539-19545	PR_EXT:000016642	denotes	TRIM11
T4927	19519-19526	GO:0005634	denotes	nucleus
T4926	19474-19485	GO:0005874	denotes	microtubule
T4925	19454-19463	GO_EXT:biological_routing_or_transport	denotes	transport
T4924	19438-19444	GO:0030286	denotes	dynein
T4923	19407-19425	GO:0015629	denotes	actin cytoskeleton
T4922	19392-19395	GO:0014069	denotes	PSD
T4921	19372-19381	GO_EXT:biological_routing_or_transport	denotes	transport
T4920	19353-19362	PR_EXT:000010865	denotes	myosin Va
T4919	19319-19326	GO:0032991	denotes	complex
T4918	19313-19318	PR_EXT:000002325	denotes	DNCL1
T4917	19308-19312	PR_EXT:000012318	denotes	PAX6
T4916	19297-19302	PR_EXT:000002325	denotes	DNCL1
T4915	19249-19257	GO:0045202	denotes	synaptic
T4914	19225-19233	GO_EXT:biological_release	denotes	released
T4913	19213-19217	PR_EXT:000012318	denotes	PAX6
T4912	19198-19206	CHEBI_PR_EXT:protein	denotes	proteins
T4911	19192-19197	PR_EXT:HOMER	denotes	HOMER
T4910	19149-19157	GO_EXT:0004872	denotes	receptor
T4909	19135-19141	PR_EXT:000008680	denotes	HOMER3
T4908	19124-19131	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T4907	20943-20948	UBERON:0000955	denotes	brain
T4906	19117-19120	GO:0014069	denotes	PSD
T4905	19098-19109	GO:0051235	denotes	sequestered
T4904	19090-19094	PR_EXT:000012318	denotes	PAX6
T4903	19057-19072	GO:0010467	denotes	gene expression
T4902	19057-19061	SO_EXT:0000704	denotes	gene
T4901	19019-19038	GO:0099536	denotes	synaptic signalling
T4900	19019-19027	GO:0045202	denotes	synaptic
T4899	18972-18977	PR_EXT:000002325	denotes	DNCL1
T4898	18961-18967	PR_EXT:000008680	denotes	HOMER3
T4897	18951-18955	PR_EXT:000012318	denotes	PAX6
T4896	18735-18746	GO:0000502	denotes	proteasomal
T4895	18717-18758	GO:0043161	denotes	ubiqutin-mediated proteasomal degradation
T4894	18717-18725	PR_EXT:ubiquitin	denotes	ubiqutin
T4893	18663-18670	PR_EXT:000008649	denotes	Humanin
T4892	18649-18655	PR_EXT:000016642	denotes	TRIM11
T4891	18565-18572	CHEBI_PR_EXT:protein	denotes	protein
T4890	18554-18561	PR_EXT:000008649	denotes	Humanin
T4889	18532-18538	PR_EXT:000016642	denotes	TRIM11
T4888	18517-18525	CHEBI_PR_EXT:protein	denotes	proteins
T4887	18471-18477	SO_EXT:0000417	denotes	domain
T4886	18444-18450	SO_EXT:0000417	denotes	domain
T4885	18432-18443	SO_EXT:0001080	denotes	coiled coil
T4884	18413-18417	CHEBI_EXT:zinc	denotes	zinc
T4883	18374-18381	CHEBI_PR_EXT:protein	denotes	protein
T4882	18359-18365	SO_EXT:sequence_or_structure_motif	denotes	motifs
T4881	18262-18269	CHEBI_PR_EXT:protein	denotes	protein
T4880	18256-18261	SO_EXT:sequence_or_structure_motif	denotes	motif
T4879	18239-18244	NCBITaxon:10088	denotes	mouse
T4878	18213-18219	PR_EXT:000016642	denotes	TRIM11
T4877	18185-18206	GO_EXT:0004517	denotes	nitric oxide synthase
T4876	18185-18197	CHEBI:16480	denotes	nitric oxide
T4875	18176-18206	PR_EXT:000011326	denotes	neuronal nitric oxide synthase
T4874	18176-18184	CL:0000540	denotes	neuronal
T4873	18159-18166	CHEBI_PR_EXT:protein	denotes	protein
T4872	18141-18147	SO_EXT:0000417	denotes	domain
T4871	18124-18166	PR_EXT:000006516	denotes	guanylate kinase domain-associated protein
T4870	18124-18140	GO_PR_EXT:guanylate_kinase	denotes	guanylate kinase
T4869	18105-18113	CHEBI_PR_EXT:protein	denotes	proteins
T4868	18101-18104	GO:0014069	denotes	PSD
T4867	18079-18084	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T4866	18073-18078	PR_EXT:000002325	denotes	DNCL1
T4865	18059-18062	GO:0014069	denotes	PSD
T4864	18030-18039	PR_EXT:000010865	denotes	Myosin Va
T4863	18013-18020	CL:0000540	denotes	neurons
T4862	18001-18009	GO:0031982	denotes	vesicles
T4861	17986-17996	GO:0043226	denotes	organelles
T4860	17976-17984	CHEBI_PR_EXT:protein	denotes	proteins
T4859	18001-18009	GO:0051650	denotes	vesicles
T4858	17973-17975	_FRAGMENT	denotes	of
T4857	17973-17984	GO:0015031	denotes	of proteins
T4856	17951-17959	_FRAGMENT	denotes	movement
T4855	17951-17959	GO:0007018	denotes	movement
T4854	17917-17934	_FRAGMENT	denotes	microtubule-based
T4853	17917-17928	GO:0005874	denotes	microtubule
T4852	17887-17896	PR_EXT:000010865	denotes	myosin Va
T4851	17876-17882	GO:0030286	denotes	Dynein
T4850	17860-17869	PR_EXT:000010865	denotes	myosin Va
T4849	17849-17855	GO:0030286	denotes	dynein
T4848	17830-17837	CHEBI_PR_EXT:protein	denotes	protein
T4847	17820-17847	GO:1990351	denotes	transport protein complexes
T4846	17811-17819	CL_GO_EXT:cell	denotes	cellular
T4845	17806-17829	GO:0046907	denotes	intracellular transport
T4844	17806-17819	GO:0005622	denotes	intracellular
T4843	17780-17785	PR_EXT:000002325	denotes	DNCL1
T4842	17756-17773	GO:0007420	denotes	brain development
T4841	17756-17761	UBERON:0000955	denotes	brain
T4840	17735-17748	GO:0007411	denotes	axon guidance
T4839	17735-17739	GO:0030424	denotes	axon
T4838	17697-17705	CHEBI_PR_EXT:protein	denotes	proteins
T4837	17691-17696	PR_EXT:HOMER	denotes	HOMER
T4836	17670-17678	CHEBI_PR_EXT:protein	denotes	proteins
T4835	17658-17669	GO_EXT:0032947	denotes	scaffolding
T4834	17654-17657	GO:0014069	denotes	PSD
T4833	17640-17649	GO_EXT:0004872	denotes	receptors
T4832	17586-17597	GO_EXT:biological_routing_or_transport	denotes	trafficking
T4831	17577-17585	GO_EXT:0004872	denotes	receptor
T4830	17562-17572	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signalling
T4829	17548-17561	GO:0098794	denotes	post-synaptic
T4828	17523-17528	UBERON:0000955	denotes	brain
T4827	17506-17515	GO:0010467	denotes	expressed
T4826	17473-17481	CHEBI_PR_EXT:protein	denotes	proteins
T4825	17457-17462	PR_EXT:HOMER	denotes	HOMER
T4824	17431-17437	PR_EXT:000008680	denotes	HOMER3
T4823	17413-17421	GO:0031982	denotes	vesicles
T4822	17404-17412	CL_GO_EXT:cell	denotes	cellular
T4821	17399-17412	GO:0005622	denotes	intracellular
T4820	17389-17393	CHEBI:29108	denotes	Ca2+
T4819	17378-17385	GO_EXT:biological_release	denotes	release
T4818	17336-17351	GO_EXT:0004629	denotes	phospholipase C
T4817	17301-17320	GO_EXT:0008066	denotes	glutamate receptors
T4816	17301-17310	CHEBI_EXT:glutamate	denotes	glutamate
T4815	17272-17277	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T4814	17251-17258	CL:0000540	denotes	neurons
T4813	17244-17247	GO:0014069	denotes	PSD
T4812	17221-17227	PR_EXT:000008680	denotes	HOMER3
T4811	17212-17219	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T4810	17201-17211	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T4809	17179-17188	SO_EXT:engineered_biological_sequence	denotes	construct
T4808	17172-17178	SO_EXT:0000417	denotes	domain
T4807	17138-17143	PR_EXT:000002325	denotes	DNCL1
T4806	17127-17133	PR_EXT:000008680	denotes	HOMER3
T4805	17101-17106	PR_EXT:000002325	denotes	DNCL1
T4804	17096-17100	PR_EXT:000012318	denotes	PAX6
T4803	17086-17092	PR_EXT:000008680	denotes	HOMER3
T4802	17081-17085	PR_EXT:000012318	denotes	PAX6
T4801	17055-17062	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T4800	17044-17054	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T4799	16992-17001	SO_EXT:engineered_biological_sequence	denotes	construct
T4798	16984-16991	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T4797	16973-16983	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T4796	16958-16963	PR_EXT:000002325	denotes	DNCL1
T4795	16948-16954	PR_EXT:000008680	denotes	HOMER3
T4794	16855-16861	PR_EXT:000016642	denotes	TRIM11
T4793	16845-16850	PR_EXT:000002325	denotes	DNCL1
T4792	16837-16843	PR_EXT:000008680	denotes	HOMER3
T4791	16826-16832	SO_EXT:0000417	denotes	domain
T4790	16785-16791	SO_EXT:0000417	denotes	domain
T4789	16758-16768	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T4788	16729-16735	PR_EXT:000016642	denotes	TRIM11
T5065	22991-23000	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T5064	22970-22980	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T5063	22809-22815	PR_EXT:000016642	denotes	TRIM11
T5062	22799-22804	PR_EXT:000002325	denotes	DNCL1
T5061	22791-22797	PR_EXT:000008680	denotes	HOMER3
T5060	22782-22786	PR_EXT:000012318	denotes	PAX6
T5059	22665-22670	UBERON:0000955	denotes	brain
T5058	22615-22638	GO:0000184	denotes	nonsense-mediated decay
T5057	22615-22623	SO_EXT:nonsense_quality_or_entity	denotes	nonsense
T5056	22596-22599	CHEBI_SO_EXT:RNA	denotes	RNA
T5055	22589-22595	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5054	22567-22574	CHEBI_PR_EXT:protein	denotes	protein
T5053	22552-22560	CHEBI_PR_EXT:protein	denotes	proteins
T5052	22542-22551	SO_EXT:sequence_truncation_process	denotes	truncated
T5051	22535-22541	SO_EXT:sequence_coding_function	denotes	encode
T5050	22506-22513	SO_EXT:0001023	denotes	alleles
T5049	22473-22491	SO_EXT:0000236	denotes	open reading frame
T5048	22468-22472	PR_EXT:000012318	denotes	PAX6
T5047	22431-22458	SO_EXT:0001587	denotes	premature termination codon
T5046	22404-22413	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T5045	22351-22358	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T5044	22340-22350	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T5043	22301-22307	SO_EXT:0000417	denotes	domain
T5042	22265-22272	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T5041	22254-22264	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T5040	22220-22226	PR_EXT:000016642	denotes	TRIM11
T5039	22159-22165	SO_EXT:0000417	denotes	domain
T5038	22132-22142	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T5037	22061-22067	PR_EXT:000016642	denotes	TRIM11
T5036	22021-22030	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T5035	21995-22002	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T5034	21984-21994	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T5033	21965-21976	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T5032	21932-21940	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T5031	21909-21916	CHEBI_PR_EXT:protein	denotes	protein
T5030	21887-21897	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T5029	21795-21803	CHEBI_PR_EXT:protein	denotes	proteins
T5028	21760-21770	GO:0006412	denotes	translated
T5027	21755-21777	SO_EXT:0000205	denotes	3' untranslated region
T5026	21734-21745	GO:0006412	denotes	translation
T5025	21712-21721	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T5024	21657-21662	PR_EXT:000002325	denotes	DNCL1
T5023	21646-21652	PR_EXT:000008680	denotes	HOMER3
T5022	21574-21583	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T5021	21543-21548	PR_EXT:000002325	denotes	DNCL1
T5020	21532-21538	PR_EXT:000008680	denotes	HOMER3
T5019	21483-21487	PR_EXT:000012318	denotes	PAX6
T5018	21460-21470	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T5017	21435-21447	SO_EXT:sequence_substitution_entity_or_process	denotes	substitution
T5016	21426-21434	CHEBI_SO_EXT:arginine	denotes	arginine
T5015	21413-21422	CHEBI_SO_EXT:glutamine	denotes	glutamine
T5014	21386-21394	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T5013	21367-21374	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T5012	21356-21366	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T5011	21351-21355	PR_EXT:000012318	denotes	PAX6
T5010	21317-21326	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T5009	21269-21274	PR_EXT:000002325	denotes	DNCL1
T5008	21259-21265	PR_EXT:000008680	denotes	HOMER3
T5007	21248-21254	SO_EXT:0000417	denotes	domain
T5006	21145-21148	CHEBI_SO_EXT:RNA	denotes	RNA
T5005	21139-21144	UBERON:0000955	denotes	brain
T5004	21133-21138	UBERON:0007023	denotes	adult
T4787	16715-16722	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T4786	16704-16714	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T4785	16667-16672	PR_EXT:000002325	denotes	DNCL1
T4784	16656-16662	PR_EXT:000008680	denotes	HOMER3
T4783	16632-16638	SO_EXT:0000417	denotes	domain
T4782	16596-16602	PR_EXT:000016642	denotes	TRIM11
T4781	16583-16589	SO_EXT:0000417	denotes	domain
T4780	16563-16570	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T4779	16552-16562	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T4778	16526-16531	PR_EXT:000002325	denotes	DNCL1
T4777	16515-16521	PR_EXT:000008680	denotes	HOMER3
T4776	16487-16493	PR_EXT:000016642	denotes	TRIM11
T4775	16477-16482	PR_EXT:000002325	denotes	DNCL1
T4774	16469-16475	PR_EXT:000008680	denotes	HOMER3
T4773	16459-16467	CHEBI_PR_EXT:protein	denotes	proteins
T4772	16410-16416	SO_EXT:0000417	denotes	domain
T4771	16384-16391	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T4770	16373-16383	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T4769	16331-16336	NCBITaxon_EXT:yeast	denotes	yeast
T4768	16309-16316	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T4767	16298-16308	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T4766	16265-16271	SO_EXT:0000417	denotes	domain
T4765	16257-16264	CHEBI_PR_EXT:protein	denotes	protein
T4764	16252-16256	PR_EXT:000012318	denotes	PAX6
T4763	16219-16231	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T4762	16210-16218	SO_EXT:biological_sequence	denotes	sequence
T4761	16199-16209	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T3381	16127-16133	SO_EXT:0000417	denotes	domain
T3380	16100-16110	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T3379	16071-16077	PR_EXT:000016642	denotes	TRIM11
T3378	16013-16019	PR_EXT:000016642	denotes	TRIM11
T3377	15973-15982	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T3376	15928-15933	PR_EXT:000002325	denotes	DNCL1
T3375	15917-15923	PR_EXT:000008680	denotes	HOMER3
T3374	15847-15856	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T3373	15818-15827	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T3372	15797-15807	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T3371	15766-15771	PR_EXT:000002325	denotes	DNCL1
T3370	15755-15761	PR_EXT:000008680	denotes	HOMER3
T3369	15695-15703	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3368	15629-15638	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T3367	15611-15617	PR_EXT:000016642	denotes	TRIM11
T3366	15601-15606	PR_EXT:000002325	denotes	DNCL1
T3365	15593-15599	PR_EXT:000008680	denotes	HOMER3
T3364	15580-15587	CHEBI_PR_EXT:protein	denotes	protein
T3363	15573-15579	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3362	15487-15496	SO_EXT:engineered_biological_sequence	denotes	construct
T3361	15444-15453	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T3360	15331-15346	UBERON:0002264	denotes	olfactory bulbs
T3359	15331-15340	GO:0007608	denotes	olfactory
T3358	15314-15326	UBERON:0001905	denotes	pineal gland
T3357	15293-15312	UBERON:0000935	denotes	anterior commissure
T3356	15240-15245	UBERON:0000955	denotes	brain
T3355	15213-15221	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3354	15155-15165	GO:0006412	denotes	translated
T3353	15150-15172	SO_EXT:0000205	denotes	3' untranslated region
T3352	15129-15140	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T3351	15078-15088	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T3350	15063-15070	CHEBI_PR_EXT:protein	denotes	protein
T3349	15058-15062	PR_EXT:000012318	denotes	PAX6
T3348	15018-15023	SO_EXT:0000360	denotes	codon
T3347	15010-15017	CHEBI_SO_EXT:leucine	denotes	leucine
T3346	14988-14998	SO_EXT:0000319	denotes	stop codon
T3345	14976-14983	SO_EXT:sequence_alteration_process	denotes	changes
T3344	14948-14958	CHEBI_SO_EXT:nucleotide	denotes	nucleotide
T3343	14946-14958	CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group	denotes	T nucleotide
T3342	14924-14933	SO_EXT:sequence_insertion_entity_or_process	denotes	Insertion
T3341	14836-14844	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3340	14804-14819	UBERON:0002336	denotes	corpus callosum
T3339	14775-14787	UBERON:0002316	denotes	white matter
T3338	14759-14769	UBERON:0002037	denotes	cerebellum
T3337	14741-14754	UBERON:0001871	denotes	temporal lobe
T3336	14727-14739	UBERON:0016525	denotes	frontal lobe
T3335	14694-14705	UBERON:0002020	denotes	grey matter
T3334	14629-14638	GO:0050890	denotes	cognition
T3333	14537-14548	NCBITaxon:1	denotes	individuals
T3332	14506-14516	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T3331	14488-14496	SO_EXT:sequence_substitution_process	denotes	replaced
T3330	14476-14483	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T3329	14465-14475	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T3328	14446-14457	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T3327	14418-14425	CHEBI_PR_EXT:protein	denotes	protein
T3326	14386-14396	GO:0006412	denotes	translated
T3325	14381-14403	SO_EXT:0000205	denotes	3' untranslated region
T3324	14345-14371	GO:0006451	denotes	translational read-through
T3323	14308-14318	SO_EXT:0000319	denotes	stop codon
T3322	14303-14307	PR_EXT:000012318	denotes	PAX6
T3321	14271-14279	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T3320	14256-14270	GO_SO_EXT:frameshift_entity_or_process	denotes	frame-shifting
T3319	14192-14200	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3318	14154-14160	UBERON:0001786	denotes	foveal
T3317	14104-14109	UBERON:0001768	denotes	uveal
T3316	14003-14011	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3315	13994-14002	SO_EXT:missense_quality_or_entity	denotes	missense
T3314	13983-13987	PR_EXT:000012318	denotes	PAX6
T3313	13974-13979	SO_EXT:0000360	denotes	codon
T3312	13949-13961	SO_EXT:sequence_substitution_entity_or_process	denotes	substitution
T3311	13938-13948	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T3310	13929-13937	CHEBI_SO_EXT:arginine	denotes	arginine
T3308	13900-13901	CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group	denotes	G
T3307	13881-13893	SO_EXT:sequence_substitution_entity_or_process	denotes	substitution
T665	15-19	PR_EXT:000012318	denotes	PAX6
T666	20-27	CHEBI_PR_EXT:protein	denotes	protein
T667	47-50	PR_EXT:000037797	denotes	PAX
T668	52-62	PR_EXT:000037797	denotes	paired-box
T669	74-89	GO_EXT:transcription	denotes	transcriptional
T670	90-100	GO_EXT:regulator	denotes	regulators
T671	129-135	UBERON:0000970	denotes	ocular
T672	129-135	_FRAGMENT	denotes	ocular
T673	147-158	GO:0001654	denotes	development
T674	140-146	UBERON_EXT:neural_tissue_or_nerve_or_nervous_system	denotes	neural
T675	140-158	GO:0007399	denotes	neural development
T676	177-186	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T677	194-199	NCBITaxon:9606	denotes	human
T678	200-204	PR_EXT:000012318	denotes	PAX6
T679	205-209	SO_EXT:0000704	denotes	gene
T680	241-245	UBERON:0001769	denotes	iris
T681	279-282	UBERON:0000970	denotes	eye
T682	302-308	UBERON_EXT:neural_tissue_or_nerve_or_nervous_system	denotes	Neural
T683	325-331	UBERON:0001786	denotes	foveal
T684	347-358	UBERON_EXT:optic_nerve	denotes	optic nerve
T685	384-388	PR_EXT:000012318	denotes	PAX6
T686	400-403	UBERON:0000970	denotes	eye
T687	430-439	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T688	443-446	NCBITaxon:9606	denotes	man
T689	451-456	NCBITaxon:10088	denotes	mouse
T690	461-467	GO_EXT:fatality_or_lethality	denotes	lethal
T691	565-574	GO:0007608	denotes	olfactory
T692	596-601	UBERON:0000955	denotes	brain
T693	636-640	PR_EXT:000012318	denotes	PAX6
T694	644-649	UBERON:0000955	denotes	brain
T695	644-661	GO:0007420	denotes	brain development
T696	701-707	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T697	708-712	NCBITaxon:10088	denotes	mice
T698	716-720	NCBITaxon:10114	denotes	rats
T699	753-768	UBERON:0000956	denotes	cerebral cortex
T700	774-786	_FRAGMENT	denotes	formation of
T701	791-828	GO:0021905	denotes	prosencephalon-mesencephalon boundary
T702	791-805	UBERON:0001890	denotes	prosencephalon
T703	806-819	UBERON:0001891	denotes	mesencephalon
T704	834-838	GO:0030424	denotes	axon
T705	834-847	GO:0007411	denotes	axon guidance
T706	853-868	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T707	872-879	CL:0000540	denotes	neurons
T708	885-889	CL:0000125	denotes	glia
T709	898-906	CL:0000540	denotes	neuronal
T710	898-916	GO:0001764	denotes	neuronal migration
T711	924-934	UBERON:0002037	denotes	cerebellum
T712	989-993	PR_EXT:000012318	denotes	PAX6
T713	997-1002	UBERON:0000955	denotes	brain
T714	997-1014	GO:0007420	denotes	brain development
T715	1086-1091	UBERON:0000955	denotes	brain
T716	1189-1208	UBERON:0000935	denotes	anterior commissure
T717	1267-1279	UBERON:0011768	denotes	pineal gland
T718	1281-1289	UBERON:0001851	denotes	cortical
T719	1306-1318	UBERON:0002316	denotes	white matter
T720	1334-1349	UBERON:0002336	denotes	corpus callosum
T721	1354-1365	UBERON:0002020	denotes	grey matter
T722	1381-1391	UBERON:0002037	denotes	cerebellum
T723	1469-1477	GO:0007605	denotes	auditory
T724	1478-1486	GO_EXT:biological_movement_or_translocation_process	denotes	transfer
T725	1524-1527	PR_EXT:000037797	denotes	PAX
T726	1528-1536	CHEBI_PR_EXT:protein	denotes	proteins
T727	1562-1572	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T728	1573-1576	CHEBI_SO_EXT:DNA	denotes	DNA
T729	1577-1584	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T730	1592-1598	SO_EXT:0000417	denotes	domain
T731	1620-1629	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T732	1676-1682	SO_EXT:0000417	denotes	domain
T733	1684-1688	PR_EXT:000012318	denotes	PAX6
T734	1705-1708	CHEBI_SO_EXT:DNA	denotes	DNA
T735	1709-1716	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T736	1735-1742	CHEBI_SO_EXT:proline	denotes	proline
T737	1744-1750	CHEBI_SO_EXT:serine	denotes	serine
T738	1755-1764	CHEBI_SO_EXT:threonine	denotes	threonine
T739	1776-1782	SO_EXT:0000417	denotes	domain
T740	1790-1800	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminus
T741	1816-1822	SO_EXT:0000417	denotes	domain
T742	1846-1856	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T743	1861-1872	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T744	1876-1880	PR_EXT:000012318	denotes	PAX6
T745	1909-1924	GO_EXT:transcription	denotes	transcriptional
T746	1944-1948	PR_EXT:000012318	denotes	PAX6
T747	1949-1956	CHEBI_PR_EXT:protein	denotes	protein
T748	1966-1975	GO:0065007	denotes	regulates
T749	1999-2004	SO_EXT:0000704	denotes	genes
T750	2021-2025	PR_EXT:000012315	denotes	Pax2
T751	2032-2036	PR_EXT:000011157	denotes	Ngn2
T752	2046-2054	CHEBI_PR_EXT:glucagon	denotes	glucagon
T753	2065-2069	PR_EXT:000012318	denotes	Pax6
T754	2070-2074	SO_EXT:0000704	denotes	gene
T755	2114-2124	GO:0010467	denotes	expression
T756	2140-2143	UBERON:0000970	denotes	eye
T757	2145-2150	UBERON:0000955	denotes	brain
T758	2152-2157	UBERON:0000004	denotes	nasal
T759	2170-2181	UBERON:0002240	denotes	spinal cord
T760	2186-2194	UBERON:0001264	denotes	pancreas
T761	2209-2213	PR_EXT:000012318	denotes	PAX6
T762	2325-2329	PR_EXT:000012318	denotes	PAX6
T763	2333-2347	UBERON:0003714	denotes	neural tissues
T764	2362-2366	PR_EXT:000012318	denotes	Pax6
T765	2367-2377	GO:0010467	denotes	expression
T766	2442-2448	UBERON:0000966	denotes	retina
T767	2462-2471	UBERON:0001950	denotes	neocortex
T768	2477-2481	PR_EXT:000012318	denotes	PAX6
T769	2522-2528	GO:0030424	denotes	axonal
T770	2553-2559	UBERON:0000966	denotes	retina
T771	2568-2573	UBERON:0000955	denotes	brain
T772	2594-2603	UBERON:0001890	denotes	forebrain
T773	2639-2654	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T774	2658-2664	UBERON_EXT:neural_tissue_or_nerve_or_nervous_system	denotes	neural
T775	2658-2669	CL:0002319	denotes	neural cell
T776	2665-2669	CL_GO_EXT:cell	denotes	cell
T777	2711-2717	UBERON:0000966	denotes	retina
T778	2731-2746	UBERON:0000956	denotes	cerebral cortex
T779	2778-2783	SO_EXT:0000704	denotes	genes
T780	2792-2796	PR_EXT:000011157	denotes	Ngn2
T781	2801-2806	PR_EXT:000004362	denotes	Mash1
T782	2851-2855	PR_EXT:000012318	denotes	PAX6
T783	2872-2878	UBERON:0000966	denotes	retina
T784	2887-2892	UBERON:0000955	denotes	brain
T785	2933-2945	UBERON:0001016	denotes	neurological
T786	2960-2971	NCBITaxon:1	denotes	individuals
T787	2977-2981	PR_EXT:000012318	denotes	PAX6
T788	2982-2991	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T790	3022-3043	GO_EXT:transcription_factor	denotes	transcription factors
T791	3113-3121	CHEBI_PR_EXT:protein	denotes	proteins
T792	3214-3224	GO:0065007	denotes	regulatory
T793	3245-3258	GO_EXT:transcription	denotes	transcription
T794	3245-3265	GO_EXT:transcription_factor	denotes	transcription factor
T795	3286-3290	PR_EXT:000012318	denotes	PAX6
T796	3291-3298	CHEBI_PR_EXT:protein	denotes	protein
T797	3299-3306	CHEBI_PR_EXT:protein	denotes	protein
T798	3346-3350	PR_EXT:000015426	denotes	SOX2
T799	3358-3362	UBERON_EXT:lens	denotes	lens
T800	3372-3380	SO_EXT:0000165	denotes	enhancer
T801	3409-3413	SO_EXT:0000704	denotes	gene
T802	3437-3446	GO:0065007	denotes	modulates
T803	3447-3451	PR_EXT:000012318	denotes	PAX6
T804	3470-3478	CL:0000540	denotes	neuronal
T805	3470-3490	GO_EXT:neuron_development_or_generation	denotes	neuronal development
T806	3510-3518	CHEBI_PR_EXT:protein	denotes	proteins
T807	3526-3534	CHEBI_PR_EXT:glucagon	denotes	glucagon
T808	3535-3543	SO_EXT:0000167	denotes	promoter
T809	3568-3581	_FRAGMENT	denotes	expression of
T810	3606-3610	GO:0010467	denotes	gene
T811	3587-3597	UBERON:0001264	denotes	pancreatic
T812	3598-3605	CHEBI_GO_EXT:hormone	denotes	hormone
T813	3606-3610	SO_EXT:0000704	denotes	gene
T814	3691-3699	CHEBI_PR_EXT:protein	denotes	proteins
T815	3719-3723	PR_EXT:000012318	denotes	PAX6
T816	3733-3741	SO_EXT:biological_sequence	denotes	sequence
T817	3823-3829	SO_EXT:0000417	denotes	domain
T818	3836-3847	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T819	3855-3865	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T820	3877-3881	PR_EXT:000012318	denotes	PAX6
T821	3882-3889	CHEBI_PR_EXT:protein	denotes	protein
T822	3910-3915	UBERON:0000955	denotes	brain
T823	3934-3941	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T824	3952-3957	NCBITaxon_EXT:yeast	denotes	yeast
T825	4018-4026	CHEBI_PR_EXT:protein	denotes	proteins
T826	4028-4034	PR_EXT:000008680	denotes	HOMER3
T827	4036-4041	PR_EXT:000002325	denotes	DNCL1
T828	4046-4052	PR_EXT:000016642	denotes	TRIM11
T829	4078-4082	PR_EXT:000012318	denotes	PAX6
T830	4093-4101	CHEBI_PR_EXT:protein	denotes	proteins
T831	4139-4149	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T832	4150-4154	PR_EXT:000012318	denotes	PAX6
T833	4155-4164	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T1715	4185-4194	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T1716	4195-4205	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T1717	4206-4210	PR_EXT:000012318	denotes	PAX6
T1718	4211-4218	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T1719	4273-4281	SO_EXT:biological_sequence	denotes	sequence
T1720	4282-4294	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T1721	4302-4312	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T1722	4324-4328	PR_EXT:000012318	denotes	PAX6
T1723	4329-4336	CHEBI_PR_EXT:protein	denotes	protein
T1724	4360-4370	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T1725	4371-4379	SO_EXT:biological_sequence	denotes	sequence
T1726	4387-4391	PR_EXT:000012318	denotes	PAX6
T1727	4396-4402	SO_EXT:0000417	denotes	domain
T1728	4404-4406	CHEBI_SO_EXT:amino_acid	denotes	aa
T1729	4434-4443	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T1730	4444-4449	SO_EXT:sequence_or_structure_motif	denotes	motif
T1731	4469-4480	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T1732	4507-4512	SO_EXT:sequence_or_structure_motif	denotes	motif
T1733	4533-4545	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T1734	4576-4583	NCBITaxon:species	denotes	species
T1735	4592-4599	NCBITaxon:8296	denotes	axolotl
T1736	4601-4620	NCBITaxon:8296	denotes	Ambystoma mexicanum
T1737	4626-4636	NCBITaxon:7625	denotes	sea urchin
T1738	4638-4659	NCBITaxon:7656	denotes	Paracentrotus lividus
T1753	5820-5829	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T1754	5970-5980	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T1755	5981-5988	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T1756	6055-6066	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T1757	6171-6179	CHEBI_EXT:residue	denotes	residues
T1758	6195-6204	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T1759	6337-6347	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T1760	6348-6355	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T1761	6378-6389	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T1762	6393-6397	PR_EXT:000012318	denotes	PAX6
T1763	6412-6421	CHEBI_SO_EXT:threonine	denotes	threonine
T1764	6433-6443	SO_EXT:0000319	denotes	stop codon
T2247	6522-6532	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T2248	6533-6540	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T2249	6562-6569	CHEBI_PR_EXT:protein	denotes	protein
T2250	6570-6577	CHEBI_PR_EXT:protein	denotes	protein
T2251	6626-6630	SO_EXT:cDNA	denotes	cDNA
T2252	6649-6654	NCBITaxon_EXT:yeast	denotes	yeast
T2253	6680-6689	SO_EXT:engineered_biological_sequence	denotes	construct
T2254	6716-6726	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T2255	6727-6737	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T2256	6738-6745	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T2257	6750-6755	SO_EXT:sequence_fusion_process	denotes	fused
T2258	6763-6768	NCBITaxon_EXT:yeast	denotes	yeast
T2259	6769-6773	PR_EXT:P04386	denotes	GAL4
T2260	6774-6777	CHEBI_SO_EXT:DNA	denotes	DNA
T2261	6778-6785	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T2262	6786-6792	SO_EXT:0000417	denotes	domain
T2263	6815-6820	NCBITaxon:10088	denotes	mouse
T2264	6821-6826	UBERON:0000955	denotes	brain
T2265	6827-6831	SO_EXT:cDNA	denotes	cDNA
T2266	6846-6851	NCBITaxon:9606	denotes	human
T2267	6902-6912	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T2268	6913-6921	SO_EXT:biological_sequence	denotes	sequence
T2269	6929-6933	PR_EXT:000012318	denotes	PAX6
T2270	6934-6941	CHEBI_PR_EXT:protein	denotes	protein
T2271	6958-6961	NCBITaxon:9606	denotes	man
T2272	6966-6971	NCBITaxon:10088	denotes	mouse
T2273	6992-6997	NCBITaxon:10088	denotes	mouse
T2274	6998-7003	UBERON:0000955	denotes	brain
T2275	7100-7109	SO_EXT:engineered_biological_sequence	denotes	construct
T2276	7135-7141	SO_EXT:0000417	denotes	domain
T2277	7157-7167	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T2278	7168-7175	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T2279	7256-7262	SO_EXT:0000417	denotes	domain
T2280	7304-7312	SO_EXT:0000155	denotes	plasmids
T2281	7335-7339	SO_EXT:cDNA	denotes	cDNA
T2282	7340-7347	SO_EXT:0000667	denotes	inserts
T2283	7365-7370	SO_EXT:cDNA	denotes	cDNAs
T2284	7404-7410	PR_EXT:000008680	denotes	Homer3
T2285	7424-7429	PR_EXT:000002325	denotes	Dncl1
T2286	7431-7437	GO:0030286	denotes	Dynein
T2287	7431-7463	PR_EXT:000002325	denotes	Dynein cytoplasmic light chain 1
T2288	7438-7449	GO:0005737	denotes	cytoplasmic
T2289	7490-7493	PR_EXT:000002325	denotes	Pin
T2290	7497-7501	PR_EXT:000002325	denotes	Dlc8
T2291	7507-7513	PR_EXT:000016642	denotes	Trim11
T2292	7515-7556	PR_EXT:000016642	denotes	Tripartite motif protein family member 11
T2293	7526-7531	SO_EXT:sequence_or_structure_motif	denotes	motif
T2294	7532-7539	CHEBI_PR_EXT:protein	denotes	protein
T2295	7570-7576	PR_EXT:000008680	denotes	Homer3
T2296	7580-7586	SO_EXT:sequence_cloned_entity	denotes	clones
T2297	7592-7597	PR_EXT:000002325	denotes	Dncl1
T2298	7601-7607	SO_EXT:sequence_cloned_entity	denotes	clones
T2299	7632-7642	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T2300	7643-7650	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T2301	7659-7665	PR_EXT:000008680	denotes	Homer3
T2302	7669-7675	SO_EXT:sequence_cloned_entity	denotes	clones
T2303	7678-7683	PR_EXT:000002325	denotes	Dncl1
T2304	7687-7693	SO_EXT:sequence_cloned_entity	denotes	clones
T2305	7699-7705	PR_EXT:000016642	denotes	Trim11
T2306	7709-7715	SO_EXT:sequence_cloned_entity	denotes	clones
T2307	7744-7750	SO_EXT:0000417	denotes	domain
T2308	7763-7767	SO_EXT:cDNA	denotes	cDNA
T2309	7768-7775	SO_EXT:0000667	denotes	inserts
T2310	7781-7789	SO:0001817	denotes	in-frame
T2311	7799-7812	SO_EXT:coding_sequence	denotes	coding region
T2312	7826-7830	PR_EXT:P04386	denotes	GAL4
T2313	7842-7848	SO_EXT:0000417	denotes	domain
T2314	7862-7867	SO_EXT:cDNA	denotes	cDNAs
T2315	7921-7927	PR_EXT:000008680	denotes	HOMER3
T2316	7947-7952	PR_EXT:HOMER	denotes	HOMER
T2317	7963-7971	CL:0000540	denotes	neuronal
T2318	7972-7993	GO:0014069	denotes	post-synaptic density
T2319	7995-7998	GO:0014069	denotes	PSD
T2320	8000-8008	CHEBI_PR_EXT:protein	denotes	proteins
T2321	8015-8020	PR_EXT:000002325	denotes	DNCL1
T2322	8041-8046	GO_EXT:biological_movement_or_translocation_process	denotes	motor
T2323	8047-8054	CHEBI_PR_EXT:protein	denotes	protein
T2324	8047-8064	GO:0043234	denotes	protein complexes
T2325	8066-8072	GO:0030286	denotes	dynein
T2326	8077-8086	PR_EXT:000010865	denotes	myosin-Va
T2327	8118-8131	GO:0005622	denotes	intracellular
T2328	8118-8155	GO:0006886	denotes	intracellular trafficking of proteins
T2329	8123-8131	CL_GO_EXT:cell	denotes	cellular
T2330	8132-8146	_FRAGMENT	denotes	trafficking of
T2331	8160-8170	GO:0051656	denotes	organelles
T2332	8147-8155	CHEBI_PR_EXT:protein	denotes	proteins
T2333	8160-8170	GO:0043226	denotes	organelles
T2334	8174-8181	CL:0000540	denotes	neurons
T2335	8191-8197	PR_EXT:000016642	denotes	TRIM11
T2336	8228-8233	SO_EXT:sequence_or_structure_motif	denotes	motif
T2337	8234-8241	CHEBI_PR_EXT:protein	denotes	protein
T2338	8285-8289	CHEBI_EXT:zinc	denotes	zinc
T2339	8300-8311	SO_EXT:0001080	denotes	coiled coil
T2340	8312-8318	SO_EXT:0000417	denotes	domain
T2341	8331-8337	SO_EXT:0000417	denotes	domain
T2342	8404-8412	CHEBI_PR_EXT:protein	denotes	proteins
T2343	8417-8421	PR_EXT:000012318	denotes	PAX6
T2808	8483-8489	PR_EXT:000008680	denotes	Homer3
T2809	8491-8496	PR_EXT:000002325	denotes	Dncl1
T2810	8501-8507	PR_EXT:000016642	denotes	Trim11
T2811	8508-8514	SO_EXT:sequence_cloned_entity	denotes	clones
T2812	8688-8694	PR_EXT:000008680	denotes	Homer3
T2813	8696-8701	PR_EXT:000002325	denotes	Dncl1
T2814	8703-8709	PR_EXT:000016642	denotes	Trim11
T2815	8714-8718	PR_EXT:000012318	denotes	Pax6
T2816	8724-8729	GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase	denotes	Gapdh
T3222	9847-9852	NCBITaxon_EXT:yeast	denotes	Yeast
T3223	9925-9933	CHEBI_PR_EXT:protein	denotes	proteins
T3224	9935-9941	PR_EXT:000008680	denotes	HOMER3
T3225	9946-9951	PR_EXT:000002325	denotes	DNCL1
T3226	9976-9986	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T3227	9987-9994	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T3228	10005-10013	CHEBI_PR_EXT:protein	denotes	proteins
T3229	10015-10021	PR_EXT:000008680	denotes	HOMER3
T3230	10023-10028	PR_EXT:000002325	denotes	DNCL1
T3231	10033-10039	PR_EXT:000016642	denotes	TRIM11
T3232	10074-10080	SO_EXT:0000417	denotes	domain
T3233	10101-10107	PR_EXT:000008680	denotes	HOMER3
T3234	10112-10117	PR_EXT:000002325	denotes	DNCL1
T3235	10149-10159	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T3236	10160-10167	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T3237	10174-10180	PR_EXT:000016642	denotes	TRIM11
T3238	10203-10213	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T3239	10230-10236	SO_EXT:0000417	denotes	domain
T3240	10283-10293	SO_EXT:engineered_biological_sequence	denotes	constructs
T3241	10406-10410	PR_EXT:000012318	denotes	PAX6
T3242	10415-10421	PR_EXT:000008680	denotes	HOMER3
T3243	10423-10428	PR_EXT:000002325	denotes	DNCL1
T3244	10433-10439	PR_EXT:000016642	denotes	TRIM11
T3245	10445-10450	PR_EXT:000002325	denotes	Dncl1
T3246	10455-10461	PR_EXT:000016642	denotes	Trim11
T3247	10462-10468	SO_EXT:sequence_cloned_entity	denotes	clones
T3248	10531-10537	PR_EXT:000008680	denotes	Homer3
T3249	10538-10543	SO_EXT:cDNA	denotes	cDNAs
T3250	10555-10565	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T3251	10569-10580	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T3252	10594-10607	SO_EXT:coding_sequence	denotes	coding region
T3253	10612-10620	SO_EXT:sequence_insertion_process	denotes	inserted
T3254	10630-10639	SO_EXT:sequence_truncation_process	denotes	truncated
T3255	10640-10646	PR_EXT:000008680	denotes	Homer3
T3256	10647-10651	SO_EXT:cDNA	denotes	cDNA
T3257	10674-10684	GO:0010467	denotes	expression
T8285	4708-4712	PR_EXT:000012318	denotes	PAX6
T8286	4713-4723	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T8287	4724-4731	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T8288	4774-4785	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T8289	4789-4793	PR_EXT:000012318	denotes	PAX6
T8290	4807-4814	NCBITaxon:species	denotes	species
T8291	4840-4848	CHEBI_EXT:residue	denotes	residues
T8292	4879-4892	SO_EXT:sequence_substitution_entity_or_process	denotes	substitutions
T8293	4930-4943	SO_EXT:sequence_substitution_entity_or_process	denotes	substitutions
T8294	4992-5001	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T8295	5014-5025	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T8296	5076-5083	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T8297	5096-5104	CHEBI_EXT:residue	denotes	residues
T8298	5122-5132	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T8439	9157-9163	PR_EXT:000008680	denotes	Homer3
T8440	9165-9170	PR_EXT:000002325	denotes	Dncl1
T8441	9172-9178	PR_EXT:000016642	denotes	Trim11
T8442	9183-9187	PR_EXT:000012318	denotes	Pax6
T8443	9195-9200	NCBITaxon:10088	denotes	mouse
T8444	9201-9206	UBERON:0000955	denotes	brain
T8445	9207-9211	SO_EXT:cDNA	denotes	cDNA
T8446	9229-9233	SO_EXT:cDNA	denotes	cDNA
T8447	9253-9260	SO_EXT:0000112	denotes	primers
T8448	9274-9278	PR_EXT:000012318	denotes	Pax6
T8449	9284-9286	SO_EXT:0000028	denotes	bp
T8450	9289-9295	PR_EXT:000008680	denotes	Homer3
T8451	9301-9303	SO_EXT:0000028	denotes	bp
T8452	9311-9316	PR_EXT:000002325	denotes	Dncl1
T8453	9322-9324	SO_EXT:0000028	denotes	bp
T8454	9330-9336	PR_EXT:000016642	denotes	Trim11
T8455	9342-9344	SO_EXT:0000028	denotes	bp
T8456	9375-9381	PR_EXT:000004453	denotes	Atp5a1
T8457	9387-9389	SO_EXT:0000028	denotes	bp
T8458	9395-9400	GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase	denotes	Gapdh
T8459	9406-9408	SO_EXT:0000028	denotes	bp
T8460	9428-9437	GO:0010467	denotes	expressed
T8461	9445-9450	UBERON:0000955	denotes	brain
T8462	9497-9502	NCBITaxon:1910954	denotes	Φ×174
T8463	9510-9513	CHEBI_SO_EXT:DNA	denotes	DNA
T8464	9519-9525	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T8465	9552-9554	SO_EXT:0000028	denotes	bp
T8466	9563-9565	SO_EXT:0000028	denotes	bp
T8467	9566-9572	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T8608	12082-12086	PR_EXT:000033987	denotes	LacZ
T8609	12096-12100	SO_EXT:0000704	denotes	gene
T8610	12137-12147	SO_EXT:engineered_biological_sequence	denotes	constructs
T8611	12185-12195	SO_EXT:engineered_biological_sequence	denotes	constructs
T8612	12241-12245	PR_EXT:000012318	denotes	PAX6
T8613	12250-12256	SO_EXT:0000417	denotes	domain
T8614	12273-12277	PR_EXT:000012318	denotes	PAX6
T8615	12282-12288	SO_EXT:0000417	denotes	domain
T8616	12304-12312	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T8617	12329-12333	PR_EXT:000012318	denotes	PAX6
T8618	12338-12344	SO_EXT:0000417	denotes	domain
T8619	12360-12368	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T8620	12389-12393	PR_EXT:000012318	denotes	PAX6
T8621	12398-12404	SO_EXT:0000417	denotes	domain
T8622	12425-12433	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T8623	12447-12451	PR_EXT:000012318	denotes	PAX6
T8624	12456-12462	SO_EXT:0000417	denotes	domain
T8625	12473-12483	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T8626	12484-12491	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T8627	12494-12503	SO_EXT:sequence_truncation_process	denotes	Truncated
T8628	12504-12510	PR_EXT:000008680	denotes	HOMER3
T8629	12515-12521	PR_EXT:000008680	denotes	HOMER3
T8630	12534-12544	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T8631	12548-12559	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T8803	12732-12738	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T8804	12739-12743	PR_EXT:000012318	denotes	PAX6
T8805	12744-12754	SO_EXT:engineered_biological_sequence	denotes	constructs
T8806	12759-12765	PR_EXT:000008680	denotes	HOMER3
T8807	12767-12772	PR_EXT:000002325	denotes	DNCL1
T8808	12777-12783	PR_EXT:000016642	denotes	TRIM11
T8809	12968-12972	PR_EXT:000012318	denotes	PAX6
T8810	12977-12983	SO_EXT:0000417	denotes	domain
T8811	12994-12998	PR_EXT:000012318	denotes	PAX6
T8812	12999-13009	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T8813	13010-13017	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T8814	13031-13035	PR_EXT:000012318	denotes	PAX6
T8815	13040-13046	SO_EXT:0000417	denotes	domain
T8816	13057-13067	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T8817	13068-13075	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T8818	13092-13096	PR_EXT:000012318	denotes	PAX6
T8819	13101-13107	SO_EXT:0000417	denotes	domain
T8820	13123-13131	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T8821	13148-13152	PR_EXT:000012318	denotes	PAX6
T8822	13157-13163	SO_EXT:0000417	denotes	domain
T8823	13179-13187	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T8824	13206-13210	PR_EXT:000012318	denotes	PAX6
T8825	13215-13221	SO_EXT:0000417	denotes	domain
T8826	13242-13250	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T8827	13252-13258	PR_EXT:000008680	denotes	HOMER3
T8828	13263-13269	PR_EXT:000008680	denotes	HOMER3
T8829	13282-13287	SO_EXT:sequence_cloned_entity	denotes	clone
T8830	13289-13295	PR_EXT:000008680	denotes	HOMER3
T8831	13296-13298	SO_EXT:sequence_truncation_entity_or_process	denotes	Tr
T8832	13300-13309	SO_EXT:sequence_truncation_process	denotes	truncated
T8833	13310-13316	PR_EXT:000008680	denotes	HOMER3
T8834	13317-13322	SO_EXT:sequence_cloned_entity	denotes	clone
T8835	13335-13345	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T8836	13349-13360	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T7919	28518-28527	GO:0010467	denotes	expressed
T7915	28467-28471	PR_EXT:000012318	denotes	Pax6
T7914	28414-28418	SO_EXT:cDNA	denotes	cDNA
T7913	28400-28406	SO_EXT:sequence_cloned_entity	denotes	clones
T2817	8734-8740	PR_EXT:000004453	denotes	Atp5a1
T2818	8742-8747	GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase	denotes	Gapdh
T2819	8752-8758	PR_EXT:000004453	denotes	Atp5a1
T2820	8789-8799	GO:0010467	denotes	expression
T2821	8816-8823	UBERON:0000479	denotes	tissues
T2822	8838-8843	UBERON:0000955	denotes	brain
T2823	8853-8859	PR_EXT:000008680	denotes	Homer3
T2824	8861-8866	PR_EXT:000002325	denotes	Dncl1
T2825	8868-8874	PR_EXT:000016642	denotes	Trim11
T2826	8879-8883	PR_EXT:000012318	denotes	Pax6
T2827	9011-9016	GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase	denotes	Gapdh
T2828	9058-9064	PR_EXT:000004453	denotes	Atp5a1
T2829	9612-9618	PR_EXT:000008680	denotes	Homer3
T2830	9620-9625	PR_EXT:000002325	denotes	Dncl1
T2831	9630-9636	PR_EXT:000016642	denotes	Trim11
T2832	9637-9643	SO_EXT:sequence_cloned_entity	denotes	clones
T2833	9756-9763	SO_EXT:sequence_coding_function	denotes	encoded
T2834	9764-9772	CHEBI_PR_EXT:protein	denotes	proteins
T2835	9804-9814	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T2836	9815-9822	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T2837	9830-9836	SO_EXT:0000417	denotes	domain
T2838	9840-9844	PR_EXT:000012318	denotes	PAX6
T1739	5200-5204	PR_EXT:000012318	denotes	PAX6
T1740	5209-5215	SO_EXT:0000417	denotes	domain
T1741	5303-5310	CHEBI_PR_EXT:protein	denotes	protein
T1742	5357-5366	SO:0000993	denotes	consensus
T1743	5415-5421	SO_EXT:0000417	denotes	domain
T1744	5489-5499	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T1745	5568-5577	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T1746	5578-5584	SO_EXT:0000417	denotes	domain
T1747	5605-5610	SO_EXT:sequence_or_structure_motif	denotes	motif
T1748	5634-5639	SO_EXT:sequence_or_structure_motif	denotes	motif
T1749	5712-5722	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T1750	5723-5729	SO_EXT:0000417	denotes	domain
T1751	5758-5763	SO_EXT:sequence_or_structure_motif	denotes	motif
T1752	5774-5784	SO_EXT:0000319	denotes	stop codon
T2246	6470-6475	NCBITaxon_EXT:yeast	denotes	Yeast
T789	3022-3035	GO_EXT:transcription	denotes	transcription
T3294	13595-13596	PR_EXT:000008680	denotes	H
T3258	10685-10694	SO_EXT:engineered_biological_sequence	denotes	construct
T3259	10779-10788	SO_EXT:sequence_truncation_process	denotes	truncated
T3260	10789-10795	PR_EXT:000008680	denotes	Homer3
T3261	10796-10802	SO_EXT:sequence_cloned_entity	denotes	clones
T3262	10832-10836	PR_EXT:000012318	denotes	PAX6
T3263	10841-10847	SO_EXT:0000417	denotes	domain
T3264	10863-10869	PR_EXT:000008680	denotes	HOMER3
T3265	10887-10896	SO_EXT:sequence_truncation_process	denotes	truncated
T3266	10897-10907	SO_EXT:engineered_biological_sequence	denotes	constructs
T3267	10910-10916	PR_EXT:000016642	denotes	TRIM11
T3268	10921-10926	PR_EXT:000002325	denotes	DNCL1
T3269	10950-10955	SO_EXT:0000704	denotes	genes
T3270	11059-11069	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T3271	11070-11077	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T3272	11082-11088	PR_EXT:000008680	denotes	HOMER3
T3273	11092-11097	PR_EXT:000002325	denotes	DNCL1
T3274	11189-11195	GO_EXT:biological_growth_entity_or_process	denotes	growth
T3275	11217-11237	CHEBI:74498	denotes	5-fluoro-orotic acid
T3276	11291-11295	PR_EXT:P03962	denotes	URA3
T3277	11314-11318	PR_EXT:P06633	denotes	HIS3
T3278	11323-11327	PR_EXT:000033987	denotes	LacZ
T3279	11542-11552	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T3280	11553-11560	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T3281	11599-11605	PR_EXT:000008680	denotes	HOMER3
T3282	11610-11615	PR_EXT:000002325	denotes	DNCL1
T3283	11656-11665	SO_EXT:engineered_biological_sequence	denotes	construct
T3284	11692-11703	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T3285	11751-11757	PR_EXT:000016642	denotes	TRIM11
T3286	11884-11890	PR_EXT:000016642	denotes	TRIM11
T3287	11917-11923	SO_EXT:0000417	denotes	domain
T3288	11941-11951	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T3289	11952-11959	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T3290	11991-12001	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T3291	12002-12009	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T3292	12055-12059	PR_EXT:000012318	denotes	PAX6
T3293	12064-12070	PR_EXT:000016642	denotes	TRIM11
T3309	13916-13925	CHEBI_SO_EXT:glutamine	denotes	glutamine
T3306	13870-13880	CHEBI_SO_EXT:nucleotide	denotes	nucleotide
T3305	13849-13857	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3304	13821-13827	UBERON:0000970	denotes	ocular
T3303	13758-13767	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T3302	13753-13757	PR_EXT:000012318	denotes	PAX6
T3301	13742-13752	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T3300	13669-13675	SO_EXT:0000417	denotes	domain
T3299	13660-13664	PR_EXT:000012318	denotes	PAX6
T3298	13635-13641	PR_EXT:000016642	denotes	TRIM11
T3297	13625-13630	PR_EXT:000002325	denotes	DNCL1
T3296	13617-13623	PR_EXT:000008680	denotes	HOMER3
T3295	13607-13609	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	rm
T5077	23289-23298	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T5076	23284-23288	PR_EXT:000012318	denotes	PAX6
T5075	23267-23278	NCBITaxon:1	denotes	individuals
T5074	23239-23246	UBERON:0000966	denotes	retinal
T5073	23183-23190	CHEBI_PR_EXT:protein	denotes	protein
R254	T673	T672	_lexicallyChainedTo	development,ocular
R255	T701	T700	_lexicallyChainedTo	prosencephalon-mesencephalon boundary,formation of
R256	T810	T809	_lexicallyChainedTo	gene,expression of
R1364	T2331	T2330	_lexicallyChainedTo	organelles,trafficking of
R2774	T4855	T4854	_lexicallyChainedTo	movement,microtubule-based
R2775	T4857	T4856	_lexicallyChainedTo	of proteins,movement
R2776	T4858	T4856	_lexicallyChainedTo	of,movement
R2777	T4859	T4858	_lexicallyChainedTo	vesicles,of
R4201	T6788	T6787	_lexicallyChainedTo	primer,reverse

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T7912	29491-29496	NCBITaxon:1910954	denotes	ΦX174
T7911	29474-29481	CHEBI:2511	denotes	agarose
T7910	29255-29261	SO:0000112	denotes	primer
T7909	29237-29242	CHEBI:6636	denotes	MgCl2
T7908	29096-29097	SO:0001031	denotes	R
T7907	29089-29095	PR:000004453	denotes	Atp5a1
T7906	29058-29059	SO:0001030	denotes	F
T7905	29051-29057	PR:000004453	denotes	Atp5a1
T7687	28315-28325	GO:0010467	denotes	expression
T7686	28283-28290	SO:0000155	denotes	plasmid
T7685	28276-28282	PR:000008680	denotes	Homer3
T7684	28082-28085	SO:0000345	denotes	EST
T7683	27933-27943	SO:0000317	denotes	cDNA clone
T7682	27898-27904	PR:000008680	denotes	Homer3
T7681	27848-27852	PR:000033987	denotes	LacZ
T7680	27839-27843	PR:P03962	denotes	URA3
T7679	27833-27837	PR:P06633	denotes	HIS3
T7678	27664-27676	GO:0009294	denotes	transforming
T7904	29020-29021	SO:0001031	denotes	R
T7903	28983-28984	SO:0001030	denotes	F
T7902	28946-28947	SO:0001031	denotes	R
T7901	28940-28945	PR:000002325	denotes	Dncl1
T7900	28911-28912	SO:0001030	denotes	F
T7899	28905-28910	PR:000002325	denotes	Dncl1
T7898	28875-28876	SO:0001031	denotes	R
T7897	28868-28874	PR:000016642	denotes	Trim11
T7896	28841-28842	SO:0001030	denotes	F
T7895	28834-28840	PR:000016642	denotes	Trim11
T7894	28801-28802	SO:0001031	denotes	R
T7893	28794-28800	PR:000008680	denotes	Homer3
T7892	28767-28768	SO:0001030	denotes	F
T7891	28760-28766	PR:000008680	denotes	Homer3
T7890	28730-28731	SO:0001031	denotes	R
T7889	28725-28729	PR:000012318	denotes	Pax6
T7888	28694-28695	SO:0001030	denotes	F
T7887	28689-28693	PR:000012318	denotes	Pax6
T7886	28666-28672	SO:0000112	denotes	Primer
T7885	28635-28642	GO:0008380	denotes	spliced
T7884	28604-28610	SO:0000188	denotes	intron
T7883	28560-28567	SO:0000112	denotes	Primers
T7882	28544-28550	PR:000004453	denotes	Atp5a1
T7881	28528-28533	SO:0000704	denotes	genes
T7880	28518-28527	GO:0010467	denotes	expressed
T7879	28488-28494	PR:000016642	denotes	Trim11
T7878	28481-28486	PR:000002325	denotes	Dncl1
T7877	28473-28479	PR:000008680	denotes	Homer3
T7876	28467-28471	PR:000012318	denotes	Pax6
T7309	27591-27597	SO:0000667	denotes	insert
T7308	27522-27528	SO:0000667	denotes	insert
T7307	27494-27498	PR:000033987	denotes	LacZ
T7306	27489-27493	PR:P03962	denotes	URA3
T7305	27484-27488	PR:P06633	denotes	HIS3
T7304	27454-27461	SO:0000155	denotes	plasmid
T7303	27385-27389	PR:P06633	denotes	HIS3
T7302	27368-27372	PR:P06633	denotes	HIS3
T7301	27249-27256	SO:0000155	denotes	plasmid
T7300	27202-27213	GO:0009294	denotes	transformed
T7299	26872-26877	CHEBI:75055	denotes	X-gal
T7298	26849-26853	PR:000033987	denotes	LacZ
T7297	26792-26796	PR:P03962	denotes	URA3
T7296	26759-26778	CHEBI:74498	denotes	5-fluro-orotic acid
T7295	26704-26708	PR:P03962	denotes	URA3
T7294	26640-26644	PR:P06633	denotes	HIS3
T7293	26625-26629	PR:P04386	denotes	GAL4
T7292	26589-26595	SO:0000417	denotes	domain
T7291	26573-26577	PR:P04386	denotes	GAL4
T7290	26512-26518	SO:0000417	denotes	domain
T7289	26495-26499	PR:P04386	denotes	GAL4
T7288	26395-26399	PR:000033987	denotes	lacZ
T7287	26386-26390	PR:P03962	denotes	URA3
T7286	26380-26384	PR:P06633	denotes	HIS3
T7285	26373-26378	SO:0000704	denotes	genes
T7284	26349-26353	PR:P04386	denotes	GAL4
T7283	26319-26325	SO:0000417	denotes	domain
T7282	26303-26307	PR:P04386	denotes	GAL4
T7281	26252-26258	SO:0000440	denotes	vector
T7280	26108-26113	UBERON:0000955	denotes	brain
T7279	26102-26107	NCBITaxon:10088	denotes	mouse
T6719	24719-24726	SO:0001030	denotes	forward
T6718	24699-24706	SO:0000112	denotes	Primers
T6717	24684-24688	PR:000012318	denotes	PAX6
T6716	24637-24643	SO:0000417	denotes	domain
T6715	24598-24604	SO:0000417	denotes	domain
T6714	24581-24585	PR:P04386	denotes	GAL4
T6713	24487-24493	SO:0000440	denotes	vector
T6712	24476-24486	GO:0010467	denotes	expression
T6711	24441-24445	PR:000012318	denotes	PAX6
T6710	24338-24345	SO:0001023	denotes	Allelic
T6709	24333-24337	PR:000012318	denotes	PAX6
T6708	24327-24332	NCBITaxon:9606	denotes	Human
T6707	24266-24270	PR:000012318	denotes	PAX6
T6706	24260-24265	NCBITaxon:9606	denotes	human
T6586	24155-24164	SO:0000993	denotes	consensus
T6585	24056-24060	PR:000012318	denotes	PAX6
T6584	24050-24055	NCBITaxon:9606	denotes	human
T6583	24018-24028	SO:0000857	denotes	homologous
T6473	23494-23498	PR:000012318	denotes	PAX6
T6472	23451-23457	PR:000016642	denotes	TRIM11
T6471	23441-23446	PR:000002325	denotes	DNCL1
T6470	23433-23439	PR:000008680	denotes	HOMER3
T6469	23413-23417	PR:000012318	denotes	PAX6
T6735	25963-25966	MOP:0000780	denotes	cut
T6734	25884-25885	SO:0001031	denotes	R
T6733	25838-25839	SO:0001030	denotes	F
T6732	25818-25825	SO:0000112	denotes	Primers
T6731	25738-25757	GO:0001171	denotes	reverse transcribed
T6730	25491-25497	SO:0000132	denotes	primer
T6729	25479-25486	_FRAGMENT	denotes	reverse
T6728	25352-25358	SO:0000417	denotes	domain
T6727	25343-25347	PR:000012318	denotes	PAX6
T6726	25215-25232	SO:0000061	denotes	restriction sites
T6725	25095-25102	MOP:0000780	denotes	cutting
T6724	25031-25037	SO:0000417	denotes	domain
T6723	24999-25000	SO:0001031	denotes	R
T6722	24936-24937	SO:0001030	denotes	F
T6721	24916-24923	SO:0000112	denotes	Primers
T6720	24787-24788	SO:0001031	denotes	R
T6482	23695-23699	PR:000012318	denotes	PAX6
T6481	23619-23626	CL:0000540	denotes	neurons
T6480	23600-23615	GO:0010467	denotes	gene expression
T6479	23600-23604	SO:0000704	denotes	gene
T6478	23579-23588	GO:0065007	denotes	regulated
T6477	23545-23564	GO:0099536	denotes	synaptic signalling
T6476	23545-23553	GO:0045202	denotes	synaptic
T6475	23515-23520	PR:000002325	denotes	DNCL1
T6474	23504-23510	PR:000008680	denotes	HOMER3
T4730	21259-21265	PR:000008680	denotes	HOMER3
T4729	21248-21254	SO:0000417	denotes	domain
T4728	21139-21144	UBERON:0000955	denotes	brain
T4727	21133-21138	UBERON:0007023	denotes	adult
T4726	21127-21132	NCBITaxon:9606	denotes	human
T4725	21107-21113	PR:000016642	denotes	TRIM11
T4724	21097-21102	PR:000002325	denotes	DNCL1
T4723	21089-21095	PR:000008680	denotes	HOMER3
T4722	21083-21087	PR:000012318	denotes	PAX6
T4721	21069-21079	GO:0010467	denotes	expression
T4720	21029-21035	UBERON:0000479	denotes	tissue
T4719	21017-21021	PR:000012318	denotes	PAX6
T4718	20967-20977	GO:0010467	denotes	expression
T4717	20943-20948	UBERON:0000955	denotes	brain
T4716	20907-20917	GO:0010467	denotes	expression
T4715	20885-20891	PR:000016642	denotes	TRIM11
T4714	20875-20880	PR:000002325	denotes	DNCL1
T4713	20858-20868	UBERON:0002037	denotes	cerebellum
T4712	20831-20840	UBERON:0001890	denotes	forebrain
T4711	20800-20805	UBERON:0000955	denotes	brain
T4710	20761-20765	UBERON:0002048	denotes	lung
T4709	20750-20756	UBERON:0002370	denotes	thymus
T4708	20718-20728	GO:0010467	denotes	expression
T4707	20711-20717	PR:000008680	denotes	HOMER3
T4706	20697-20703	UBERON:0000479	denotes	tissue
T4705	20683-20688	PR:000002325	denotes	DNCL1
T4704	20672-20678	PR:000016642	denotes	TRIM11
T4703	20647-20651	PR:000012318	denotes	PAX6
T4702	20639-20646	GO:0005634	denotes	nuclear
T4701	20576-20580	PR:000012318	denotes	PAX6
T4700	20564-20575	GO:0005737	denotes	cytoplasmic
T4699	20536-20547	GO:0005737	denotes	cytoplasmic
T4698	20524-20531	GO:0005634	denotes	nuclear
T4697	20509-20515	PR:000016642	denotes	TRIM11
T4696	20460-20467	GO:0005634	denotes	nuclear
T4695	20438-20449	GO:0005737	denotes	cytoplasmic
T4694	20421-20426	PR:000002325	denotes	DNCL1
T4693	20405-20414	GO:0005737	denotes	cytoplasm
T4692	20393-20396	GO:0014069	denotes	PSD
T4691	20334-20340	PR:000008680	denotes	HOMER3
T4690	20224-20227	GO:0014069	denotes	PSD
T4689	20167-20175	CL:0000540	denotes	neurones
T4688	20115-20120	UBERON:0000955	denotes	brain
T4687	20081-20088	SO:0001060	denotes	isoform
T4686	20060-20064	NCBITaxon:10088	denotes	mice
T4685	19991-20002	GO:0005737	denotes	cytoplasmic
T4684	19979-19986	GO:0005634	denotes	nuclear
T4683	19963-19969	SO:0000417	denotes	domain
T4682	19933-19940	SO:0001060	denotes	isoform
T4681	19917-19925	NCBITaxon:6231	denotes	nematode
T4680	19900-19905	NCBITaxon:10088	denotes	mouse
T4679	19865-19872	GO:0005634	denotes	nuclear
T4678	19835-19839	PR:000012318	denotes	PAX6
T4677	19793-19800	GO:0005634	denotes	nucleus
T4676	19777-19784	GO:0045202	denotes	synapse
T4675	19754-19764	CHEBI:33280	denotes	messengers
T4674	19725-19730	PR:000002089	denotes	STAT3
T4673	19695-19716	GO:0014069	denotes	post-synaptic density
T4672	19611-19615	PR:000012318	denotes	PAX6
T4671	19563-19582	GO:0030163	denotes	protein degradation
T4670	19539-19545	PR:000016642	denotes	TRIM11
T4669	19519-19526	GO:0005634	denotes	nucleus
T4668	19474-19485	GO:0005874	denotes	microtubule
T4667	19438-19444	GO:0030286	denotes	dynein
T4666	19407-19425	GO:0015629	denotes	actin cytoskeleton
T4665	19392-19395	GO:0014069	denotes	PSD
T4664	19353-19362	PR:000010865	denotes	myosin Va
T4663	19319-19326	GO:0032991	denotes	complex
T4662	19313-19318	PR:000002325	denotes	DNCL1
T4661	19308-19312	PR:000012318	denotes	PAX6
T4660	19297-19302	PR:000002325	denotes	DNCL1
T4659	19249-19257	GO:0045202	denotes	synaptic
T4658	19213-19217	PR:000012318	denotes	PAX6
T4657	19135-19141	PR:000008680	denotes	HOMER3
T4656	19117-19120	GO:0014069	denotes	PSD
T4655	19098-19109	GO:0051235	denotes	sequestered
T4654	19090-19094	PR:000012318	denotes	PAX6
T4653	19057-19072	GO:0010467	denotes	gene expression
T4652	19057-19061	SO:0000704	denotes	gene
T4651	19019-19038	GO:0099536	denotes	synaptic signalling
T4650	19019-19027	GO:0045202	denotes	synaptic
T4649	18972-18977	PR:000002325	denotes	DNCL1
T4648	18961-18967	PR:000008680	denotes	HOMER3
T4647	18951-18955	PR:000012318	denotes	PAX6
T4646	18735-18746	GO:0000502	denotes	proteasomal
T4645	18717-18758	GO:0043161	denotes	ubiqutin-mediated proteasomal degradation
T4644	18663-18670	PR:000008649	denotes	Humanin
T4643	18649-18655	PR:000016642	denotes	TRIM11
T4642	18554-18561	PR:000008649	denotes	Humanin
T4641	18532-18538	PR:000016642	denotes	TRIM11
T4640	18471-18477	SO:0000417	denotes	domain
T4639	18444-18450	SO:0000417	denotes	domain
T4638	18432-18443	SO:0001080	denotes	coiled coil
T4637	18239-18244	NCBITaxon:10088	denotes	mouse
T4636	18213-18219	PR:000016642	denotes	TRIM11
T4635	18185-18197	CHEBI:16480	denotes	nitric oxide
T4634	18176-18206	PR:000011326	denotes	neuronal nitric oxide synthase
T4633	18176-18184	CL:0000540	denotes	neuronal
T4632	18141-18147	SO:0000417	denotes	domain
T4631	18124-18166	PR:000006516	denotes	guanylate kinase domain-associated protein
T4630	18101-18104	GO:0014069	denotes	PSD
T4629	18073-18078	PR:000002325	denotes	DNCL1
T4628	18059-18062	GO:0014069	denotes	PSD
T4627	18030-18039	PR:000010865	denotes	Myosin Va
T4626	18013-18020	CL:0000540	denotes	neurons
T4625	18001-18009	GO:0031982	denotes	vesicles
T4624	17986-17996	GO:0043226	denotes	organelles
T4623	18001-18009	GO:0051650	denotes	vesicles
T4622	17973-17975	_FRAGMENT	denotes	of
T4621	17973-17984	GO:0015031	denotes	of proteins
T4620	17951-17959	_FRAGMENT	denotes	movement
T4619	17951-17959	GO:0007018	denotes	movement
T4618	17917-17934	_FRAGMENT	denotes	microtubule-based
T4617	17917-17928	GO:0005874	denotes	microtubule
T4616	17887-17896	PR:000010865	denotes	myosin Va
T4615	17876-17882	GO:0030286	denotes	Dynein
T4614	17860-17869	PR:000010865	denotes	myosin Va
T4613	17849-17855	GO:0030286	denotes	dynein
T4612	17820-17847	GO:1990351	denotes	transport protein complexes
T4611	17806-17829	GO:0046907	denotes	intracellular transport
T4610	17806-17819	GO:0005622	denotes	intracellular
T4609	17780-17785	PR:000002325	denotes	DNCL1
T4608	17756-17773	GO:0007420	denotes	brain development
T4607	17756-17761	UBERON:0000955	denotes	brain
T4606	17735-17748	GO:0007411	denotes	axon guidance
T4605	17735-17739	GO:0030424	denotes	axon
T4604	17654-17657	GO:0014069	denotes	PSD
T4603	17548-17561	GO:0098794	denotes	post-synaptic
T4602	17523-17528	UBERON:0000955	denotes	brain
T4601	17506-17515	GO:0010467	denotes	expressed
T4600	17431-17437	PR:000008680	denotes	HOMER3
T4599	17413-17421	GO:0031982	denotes	vesicles
T4598	17399-17412	GO:0005622	denotes	intracellular
T4597	17389-17393	CHEBI:29108	denotes	Ca2+
T4596	17251-17258	CL:0000540	denotes	neurons
T4595	17244-17247	GO:0014069	denotes	PSD
T4594	17221-17227	PR:000008680	denotes	HOMER3
T4593	17172-17178	SO:0000417	denotes	domain
T4592	17138-17143	PR:000002325	denotes	DNCL1
T4591	17127-17133	PR:000008680	denotes	HOMER3
T4590	17101-17106	PR:000002325	denotes	DNCL1
T4589	17096-17100	PR:000012318	denotes	PAX6
T4588	17086-17092	PR:000008680	denotes	HOMER3
T4587	17081-17085	PR:000012318	denotes	PAX6
T4586	16958-16963	PR:000002325	denotes	DNCL1
T4585	16948-16954	PR:000008680	denotes	HOMER3
T4584	16855-16861	PR:000016642	denotes	TRIM11
T4583	16845-16850	PR:000002325	denotes	DNCL1
T4582	16837-16843	PR:000008680	denotes	HOMER3
T4581	16826-16832	SO:0000417	denotes	domain
T4580	16785-16791	SO:0000417	denotes	domain
T4579	16729-16735	PR:000016642	denotes	TRIM11
T4578	16667-16672	PR:000002325	denotes	DNCL1
T4577	16656-16662	PR:000008680	denotes	HOMER3
T4576	16632-16638	SO:0000417	denotes	domain
T4575	16596-16602	PR:000016642	denotes	TRIM11
T4574	16583-16589	SO:0000417	denotes	domain
T4573	16526-16531	PR:000002325	denotes	DNCL1
T4572	16515-16521	PR:000008680	denotes	HOMER3
T4571	16487-16493	PR:000016642	denotes	TRIM11
T4570	16477-16482	PR:000002325	denotes	DNCL1
T4569	16469-16475	PR:000008680	denotes	HOMER3
T4568	16410-16416	SO:0000417	denotes	domain
T4567	16265-16271	SO:0000417	denotes	domain
T4566	16252-16256	PR:000012318	denotes	PAX6
T3221	16127-16133	SO:0000417	denotes	domain
T3220	16071-16077	PR:000016642	denotes	TRIM11
T3219	16013-16019	PR:000016642	denotes	TRIM11
T3218	15928-15933	PR:000002325	denotes	DNCL1
T3217	15917-15923	PR:000008680	denotes	HOMER3
T3216	15766-15771	PR:000002325	denotes	DNCL1
T3215	15755-15761	PR:000008680	denotes	HOMER3
T3214	15611-15617	PR:000016642	denotes	TRIM11
T3213	15601-15606	PR:000002325	denotes	DNCL1
T3212	15593-15599	PR:000008680	denotes	HOMER3
T3211	15331-15346	UBERON:0002264	denotes	olfactory bulbs
T3210	15331-15340	GO:0007608	denotes	olfactory
T3209	15314-15326	UBERON:0001905	denotes	pineal gland
T3208	15293-15312	UBERON:0000935	denotes	anterior commissure
T3207	15240-15245	UBERON:0000955	denotes	brain
T3206	15155-15165	GO:0006412	denotes	translated
T3205	15150-15172	SO:0000205	denotes	3' untranslated region
T3204	15058-15062	PR:000012318	denotes	PAX6
T3203	15018-15023	SO:0000360	denotes	codon
T3202	14988-14998	SO:0000319	denotes	stop codon
T3201	14804-14819	UBERON:0002336	denotes	corpus callosum
T3200	14775-14787	UBERON:0002316	denotes	white matter
T3199	14759-14769	UBERON:0002037	denotes	cerebellum
T3198	14741-14754	UBERON:0001871	denotes	temporal lobe
T3197	14727-14739	UBERON:0016525	denotes	frontal lobe
T3196	14694-14705	UBERON:0002020	denotes	grey matter
T3195	14629-14638	GO:0050890	denotes	cognition
T3194	14537-14548	NCBITaxon:1	denotes	individuals
T3193	14386-14396	GO:0006412	denotes	translated
T3192	14381-14403	SO:0000205	denotes	3' untranslated region
T3191	14345-14371	GO:0006451	denotes	translational read-through
T3190	14308-14318	SO:0000319	denotes	stop codon
T3189	14303-14307	PR:000012318	denotes	PAX6
T3188	14154-14160	UBERON:0001786	denotes	foveal
T3187	14104-14109	UBERON:0001768	denotes	uveal
T3186	13983-13987	PR:000012318	denotes	PAX6
T3185	13974-13979	SO:0000360	denotes	codon
T3184	13821-13827	UBERON:0000970	denotes	ocular
T3183	13753-13757	PR:000012318	denotes	PAX6
T3182	13669-13675	SO:0000417	denotes	domain
T3181	13660-13664	PR:000012318	denotes	PAX6
T3180	13635-13641	PR:000016642	denotes	TRIM11
T3179	13625-13630	PR:000002325	denotes	DNCL1
T3178	13617-13623	PR:000008680	denotes	HOMER3
T3177	13595-13596	PR:000008680	denotes	H
T550	15-19	PR:000012318	denotes	PAX6
T551	47-50	PR:000037797	denotes	PAX
T552	52-62	PR:000037797	denotes	paired-box
T553	129-135	UBERON:0000970	denotes	ocular
T554	129-135	_FRAGMENT	denotes	ocular
T555	147-158	GO:0001654	denotes	development
T556	140-158	GO:0007399	denotes	neural development
T557	194-199	NCBITaxon:9606	denotes	human
T558	200-204	PR:000012318	denotes	PAX6
T559	205-209	SO:0000704	denotes	gene
T560	241-245	UBERON:0001769	denotes	iris
T561	279-282	UBERON:0000970	denotes	eye
T562	325-331	UBERON:0001786	denotes	foveal
T563	347-352	UBERON:0000970	denotes	optic
T564	384-388	PR:000012318	denotes	PAX6
T565	400-403	UBERON:0000970	denotes	eye
T566	443-446	NCBITaxon:9606	denotes	man
T567	451-456	NCBITaxon:10088	denotes	mouse
T568	565-574	GO:0007608	denotes	olfactory
T569	596-601	UBERON:0000955	denotes	brain
T570	636-640	PR:000012318	denotes	PAX6
T571	644-649	UBERON:0000955	denotes	brain
T572	644-661	GO:0007420	denotes	brain development
T573	708-712	NCBITaxon:10088	denotes	mice
T574	716-720	NCBITaxon:10114	denotes	rats
T575	753-768	UBERON:0000956	denotes	cerebral cortex
T576	774-786	_FRAGMENT	denotes	formation of
T577	791-828	GO:0021905	denotes	prosencephalon-mesencephalon boundary
T578	791-805	UBERON:0001890	denotes	prosencephalon
T579	806-819	UBERON:0001891	denotes	mesencephalon
T581	834-847	GO:0007411	denotes	axon guidance
T582	872-879	CL:0000540	denotes	neurons
T583	885-889	CL:0000125	denotes	glia
T584	898-906	CL:0000540	denotes	neuronal
T585	898-916	GO:0001764	denotes	neuronal migration
T586	924-934	UBERON:0002037	denotes	cerebellum
T587	989-993	PR:000012318	denotes	PAX6
T588	997-1002	UBERON:0000955	denotes	brain
T589	997-1014	GO:0007420	denotes	brain development
T590	1086-1091	UBERON:0000955	denotes	brain
T591	1189-1208	UBERON:0000935	denotes	anterior commissure
T592	1267-1279	UBERON:0011768	denotes	pineal gland
T593	1281-1289	UBERON:0001851	denotes	cortical
T594	1306-1318	UBERON:0002316	denotes	white matter
T595	1334-1349	UBERON:0002336	denotes	corpus callosum
T596	1354-1365	UBERON:0002020	denotes	grey matter
T597	1381-1391	UBERON:0002037	denotes	cerebellum
T598	1469-1477	GO:0007605	denotes	auditory
T599	1524-1527	PR:000037797	denotes	PAX
T600	1592-1598	SO:0000417	denotes	domain
T601	1676-1682	SO:0000417	denotes	domain
T602	1684-1688	PR:000012318	denotes	PAX6
T603	1776-1782	SO:0000417	denotes	domain
T604	1816-1822	SO:0000417	denotes	domain
T605	1876-1880	PR:000012318	denotes	PAX6
T606	1944-1948	PR:000012318	denotes	PAX6
T607	1966-1975	GO:0065007	denotes	regulates
T608	1999-2004	SO:0000704	denotes	genes
T609	2021-2025	PR:000012315	denotes	Pax2
T610	2032-2036	PR:000011157	denotes	Ngn2
T611	2065-2069	PR:000012318	denotes	Pax6
T612	2070-2074	SO:0000704	denotes	gene
T613	2114-2124	GO:0010467	denotes	expression
T614	2140-2143	UBERON:0000970	denotes	eye
T615	2145-2150	UBERON:0000955	denotes	brain
T616	2152-2157	UBERON:0000004	denotes	nasal
T617	2170-2181	UBERON:0002240	denotes	spinal cord
T618	2186-2194	UBERON:0001264	denotes	pancreas
T619	2209-2213	PR:000012318	denotes	PAX6
T620	2325-2329	PR:000012318	denotes	PAX6
T621	2333-2347	UBERON:0003714	denotes	neural tissues
T622	2362-2366	PR:000012318	denotes	Pax6
T623	2367-2377	GO:0010467	denotes	expression
T624	2442-2448	UBERON:0000966	denotes	retina
T625	2462-2471	UBERON:0001950	denotes	neocortex
T626	2477-2481	PR:000012318	denotes	PAX6
T627	2522-2528	GO:0030424	denotes	axonal
T628	2553-2559	UBERON:0000966	denotes	retina
T629	2568-2573	UBERON:0000955	denotes	brain
T630	2594-2603	UBERON:0001890	denotes	forebrain
T631	2658-2669	CL:0002319	denotes	neural cell
T632	2711-2717	UBERON:0000966	denotes	retina
T633	2731-2746	UBERON:0000956	denotes	cerebral cortex
T634	2778-2783	SO:0000704	denotes	genes
T635	2792-2796	PR:000011157	denotes	Ngn2
T636	2801-2806	PR:000004362	denotes	Mash1
T637	2851-2855	PR:000012318	denotes	PAX6
T638	2872-2878	UBERON:0000966	denotes	retina
T639	2887-2892	UBERON:0000955	denotes	brain
T640	2933-2945	UBERON:0001016	denotes	neurological
T641	2960-2971	NCBITaxon:1	denotes	individuals
T642	2977-2981	PR:000012318	denotes	PAX6
T643	3214-3224	GO:0065007	denotes	regulatory
T644	3286-3290	PR:000012318	denotes	PAX6
T645	3346-3350	PR:000015426	denotes	SOX2
T646	3372-3380	SO:0000165	denotes	enhancer
T647	3409-3413	SO:0000704	denotes	gene
T648	3437-3446	GO:0065007	denotes	modulates
T649	3447-3451	PR:000012318	denotes	PAX6
T650	3470-3478	CL:0000540	denotes	neuronal
T651	3535-3543	SO:0000167	denotes	promoter
T652	3568-3581	_FRAGMENT	denotes	expression of
T653	3606-3610	GO:0010467	denotes	gene
T654	3587-3597	UBERON:0001264	denotes	pancreatic
T655	3606-3610	SO:0000704	denotes	gene
T656	3719-3723	PR:000012318	denotes	PAX6
T657	3823-3829	SO:0000417	denotes	domain
T658	3877-3881	PR:000012318	denotes	PAX6
T659	3910-3915	UBERON:0000955	denotes	brain
T660	4028-4034	PR:000008680	denotes	HOMER3
T661	4036-4041	PR:000002325	denotes	DNCL1
T662	4046-4052	PR:000016642	denotes	TRIM11
T663	4078-4082	PR:000012318	denotes	PAX6
T664	4150-4154	PR:000012318	denotes	PAX6
T1697	4206-4210	PR:000012318	denotes	PAX6
T1698	4324-4328	PR:000012318	denotes	PAX6
T1699	4387-4391	PR:000012318	denotes	PAX6
T1700	4396-4402	SO:0000417	denotes	domain
T1701	4576-4583	NCBITaxon:species	denotes	species
T1702	4592-4599	NCBITaxon:8296	denotes	axolotl
T1703	4601-4620	NCBITaxon:8296	denotes	Ambystoma mexicanum
T1704	4626-4636	NCBITaxon:7625	denotes	sea urchin
T1705	4638-4659	NCBITaxon:7656	denotes	Paracentrotus lividus
T1706	5200-5204	PR:000012318	denotes	PAX6
T1707	5209-5215	SO:0000417	denotes	domain
T1708	5357-5366	SO:0000993	denotes	consensus
T1709	5415-5421	SO:0000417	denotes	domain
T1710	5578-5584	SO:0000417	denotes	domain
T1711	5723-5729	SO:0000417	denotes	domain
T1712	5774-5784	SO:0000319	denotes	stop codon
T1713	6393-6397	PR:000012318	denotes	PAX6
T1714	6433-6443	SO:0000319	denotes	stop codon
T2194	6769-6773	PR:P04386	denotes	GAL4
T2195	6786-6792	SO:0000417	denotes	domain
T2196	6815-6820	NCBITaxon:10088	denotes	mouse
T2197	6821-6826	UBERON:0000955	denotes	brain
T2198	6846-6851	NCBITaxon:9606	denotes	human
T2199	6929-6933	PR:000012318	denotes	PAX6
T2200	6958-6961	NCBITaxon:9606	denotes	man
T2201	6966-6971	NCBITaxon:10088	denotes	mouse
T2202	6992-6997	NCBITaxon:10088	denotes	mouse
T2203	6998-7003	UBERON:0000955	denotes	brain
T2204	7135-7141	SO:0000417	denotes	domain
T2205	7256-7262	SO:0000417	denotes	domain
T2206	7304-7312	SO:0000155	denotes	plasmids
T2207	7340-7347	SO:0000667	denotes	inserts
T2208	7404-7410	PR:000008680	denotes	Homer3
T2209	7424-7429	PR:000002325	denotes	Dncl1
T2210	7431-7437	GO:0030286	denotes	Dynein
T2211	7431-7463	PR:000002325	denotes	Dynein cytoplasmic light chain 1
T2212	7438-7449	GO:0005737	denotes	cytoplasmic
T2213	7490-7493	PR:000002325	denotes	Pin
T2214	7497-7501	PR:000002325	denotes	Dlc8
T2215	7507-7513	PR:000016642	denotes	Trim11
T2216	7515-7556	PR:000016642	denotes	Tripartite motif protein family member 11
T2217	7570-7576	PR:000008680	denotes	Homer3
T2218	7592-7597	PR:000002325	denotes	Dncl1
T2219	7659-7665	PR:000008680	denotes	Homer3
T2220	7678-7683	PR:000002325	denotes	Dncl1
T2221	7699-7705	PR:000016642	denotes	Trim11
T2222	7744-7750	SO:0000417	denotes	domain
T2223	7768-7775	SO:0000667	denotes	inserts
T2224	7781-7789	SO:0001817	denotes	in-frame
T2225	7826-7830	PR:P04386	denotes	GAL4
T2226	7842-7848	SO:0000417	denotes	domain
T2227	7921-7927	PR:000008680	denotes	HOMER3
T2228	7963-7971	CL:0000540	denotes	neuronal
T2229	7972-7993	GO:0014069	denotes	post-synaptic density
T2230	7995-7998	GO:0014069	denotes	PSD
T2231	8015-8020	PR:000002325	denotes	DNCL1
T2232	8047-8064	GO:0043234	denotes	protein complexes
T2233	8066-8072	GO:0030286	denotes	dynein
T2234	8077-8086	PR:000010865	denotes	myosin-Va
T2235	8118-8131	GO:0005622	denotes	intracellular
T2236	8118-8155	GO:0006886	denotes	intracellular trafficking of proteins
T2237	8132-8146	_FRAGMENT	denotes	trafficking of
T2238	8160-8170	GO:0051656	denotes	organelles
T2239	8160-8170	GO:0043226	denotes	organelles
T2240	8174-8181	CL:0000540	denotes	neurons
T2241	8191-8197	PR:000016642	denotes	TRIM11
T2242	8300-8311	SO:0001080	denotes	coiled coil
T2243	8312-8318	SO:0000417	denotes	domain
T2244	8331-8337	SO:0000417	denotes	domain
T2245	8417-8421	PR:000012318	denotes	PAX6
T2786	8483-8489	PR:000008680	denotes	Homer3
T2787	8491-8496	PR:000002325	denotes	Dncl1
T2788	8501-8507	PR:000016642	denotes	Trim11
T2789	8688-8694	PR:000008680	denotes	Homer3
T2790	8696-8701	PR:000002325	denotes	Dncl1
T2797	8838-8843	UBERON:0000955	denotes	brain
T2798	8853-8859	PR:000008680	denotes	Homer3
T2799	8861-8866	PR:000002325	denotes	Dncl1
T2800	8868-8874	PR:000016642	denotes	Trim11
T2801	8879-8883	PR:000012318	denotes	Pax6
T2802	9058-9064	PR:000004453	denotes	Atp5a1
T2803	9612-9618	PR:000008680	denotes	Homer3
T2804	9620-9625	PR:000002325	denotes	Dncl1
T2805	9630-9636	PR:000016642	denotes	Trim11
T2806	9830-9836	SO:0000417	denotes	domain
T2807	9840-9844	PR:000012318	denotes	PAX6
T3138	9935-9941	PR:000008680	denotes	HOMER3
T3139	9946-9951	PR:000002325	denotes	DNCL1
T3140	10015-10021	PR:000008680	denotes	HOMER3
T3141	10023-10028	PR:000002325	denotes	DNCL1
T3142	10033-10039	PR:000016642	denotes	TRIM11
T3143	10074-10080	SO:0000417	denotes	domain
T3174	11917-11923	SO:0000417	denotes	domain
T3175	12055-12059	PR:000012318	denotes	PAX6
T3176	12064-12070	PR:000016642	denotes	TRIM11
T8282	4708-4712	PR:000012318	denotes	PAX6
T8283	4789-4793	PR:000012318	denotes	PAX6
T8284	4807-4814	NCBITaxon:species	denotes	species
T8416	9157-9163	PR:000008680	denotes	Homer3
T8417	9165-9170	PR:000002325	denotes	Dncl1
T8418	9172-9178	PR:000016642	denotes	Trim11
T8419	9183-9187	PR:000012318	denotes	Pax6
T8420	9195-9200	NCBITaxon:10088	denotes	mouse
T8421	9201-9206	UBERON:0000955	denotes	brain
T8422	9253-9260	SO:0000112	denotes	primers
T8423	9274-9278	PR:000012318	denotes	Pax6
T8424	9284-9286	SO:0000028	denotes	bp
T8425	9289-9295	PR:000008680	denotes	Homer3
T8426	9301-9303	SO:0000028	denotes	bp
T8427	9311-9316	PR:000002325	denotes	Dncl1
T8428	9322-9324	SO:0000028	denotes	bp
T8429	9330-9336	PR:000016642	denotes	Trim11
T8430	9342-9344	SO:0000028	denotes	bp
T8431	9375-9381	PR:000004453	denotes	Atp5a1
T8432	9387-9389	SO:0000028	denotes	bp
T8433	9406-9408	SO:0000028	denotes	bp
T8434	9428-9437	GO:0010467	denotes	expressed
T8435	9445-9450	UBERON:0000955	denotes	brain
T8436	9497-9502	NCBITaxon:1910954	denotes	Φ×174
T8437	9552-9554	SO:0000028	denotes	bp
T8438	9563-9565	SO:0000028	denotes	bp
T8594	12082-12086	PR:000033987	denotes	LacZ
T8595	12096-12100	SO:0000704	denotes	gene
T8596	12241-12245	PR:000012318	denotes	PAX6
T8597	12250-12256	SO:0000417	denotes	domain
T8598	12273-12277	PR:000012318	denotes	PAX6
T8599	12282-12288	SO:0000417	denotes	domain
T8600	12329-12333	PR:000012318	denotes	PAX6
T8601	12338-12344	SO:0000417	denotes	domain
T8602	12389-12393	PR:000012318	denotes	PAX6
T8603	12398-12404	SO:0000417	denotes	domain
T8604	12447-12451	PR:000012318	denotes	PAX6
T8605	12456-12462	SO:0000417	denotes	domain
T8606	12504-12510	PR:000008680	denotes	HOMER3
T8607	12515-12521	PR:000008680	denotes	HOMER3
T8784	12739-12743	PR:000012318	denotes	PAX6
T8785	12759-12765	PR:000008680	denotes	HOMER3
T8786	12767-12772	PR:000002325	denotes	DNCL1
T8787	12777-12783	PR:000016642	denotes	TRIM11
T8788	12968-12972	PR:000012318	denotes	PAX6
T8789	12977-12983	SO:0000417	denotes	domain
T8790	12994-12998	PR:000012318	denotes	PAX6
T8791	13031-13035	PR:000012318	denotes	PAX6
T8792	13040-13046	SO:0000417	denotes	domain
T8793	13092-13096	PR:000012318	denotes	PAX6
T8794	13101-13107	SO:0000417	denotes	domain
T8795	13148-13152	PR:000012318	denotes	PAX6
T8796	13157-13163	SO:0000417	denotes	domain
T8797	13206-13210	PR:000012318	denotes	PAX6
T8798	13215-13221	SO:0000417	denotes	domain
T8799	13252-13258	PR:000008680	denotes	HOMER3
T8800	13263-13269	PR:000008680	denotes	HOMER3
T8801	13289-13295	PR:000008680	denotes	HOMER3
T8802	13310-13316	PR:000008680	denotes	HOMER3
T6468	23368-23386	GO:0007399	denotes	neurodevelopmental
T2791	8703-8709	PR:000016642	denotes	Trim11
T2792	8714-8718	PR:000012318	denotes	Pax6
T2793	8734-8740	PR:000004453	denotes	Atp5a1
T2794	8752-8758	PR:000004453	denotes	Atp5a1
T2795	8789-8799	GO:0010467	denotes	expression
T2796	8816-8823	UBERON:0000479	denotes	tissues
T580	834-838	GO:0030424	denotes	axon
T3144	10101-10107	PR:000008680	denotes	HOMER3
T3145	10112-10117	PR:000002325	denotes	DNCL1
T3146	10174-10180	PR:000016642	denotes	TRIM11
T3147	10230-10236	SO:0000417	denotes	domain
T3148	10406-10410	PR:000012318	denotes	PAX6
T3149	10415-10421	PR:000008680	denotes	HOMER3
T3150	10423-10428	PR:000002325	denotes	DNCL1
T3151	10433-10439	PR:000016642	denotes	TRIM11
T3152	10445-10450	PR:000002325	denotes	Dncl1
T3153	10455-10461	PR:000016642	denotes	Trim11
T3154	10531-10537	PR:000008680	denotes	Homer3
T3155	10640-10646	PR:000008680	denotes	Homer3
T3156	10674-10684	GO:0010467	denotes	expression
T3157	10789-10795	PR:000008680	denotes	Homer3
T3158	10832-10836	PR:000012318	denotes	PAX6
T3159	10841-10847	SO:0000417	denotes	domain
T3160	10863-10869	PR:000008680	denotes	HOMER3
T3161	10910-10916	PR:000016642	denotes	TRIM11
T3162	10921-10926	PR:000002325	denotes	DNCL1
T3163	10950-10955	SO:0000704	denotes	genes
T3164	11082-11088	PR:000008680	denotes	HOMER3
T3165	11092-11097	PR:000002325	denotes	DNCL1
T3166	11217-11237	CHEBI:74498	denotes	5-fluoro-orotic acid
T3167	11291-11295	PR:P03962	denotes	URA3
T3168	11314-11318	PR:P06633	denotes	HIS3
T3169	11323-11327	PR:000033987	denotes	LacZ
T3170	11599-11605	PR:000008680	denotes	HOMER3
T3171	11610-11615	PR:000002325	denotes	DNCL1
T3172	11751-11757	PR:000016642	denotes	TRIM11
T3173	11884-11890	PR:000016642	denotes	TRIM11
T4755	23102-23107	UBERON:0000955	denotes	brain
T4754	22809-22815	PR:000016642	denotes	TRIM11
T4753	22799-22804	PR:000002325	denotes	DNCL1
T4752	22791-22797	PR:000008680	denotes	HOMER3
T4751	22782-22786	PR:000012318	denotes	PAX6
T4750	22665-22670	UBERON:0000955	denotes	brain
T4749	22615-22638	GO:0000184	denotes	nonsense-mediated decay
T4748	22506-22513	SO:0001023	denotes	alleles
T4747	22473-22491	SO:0000236	denotes	open reading frame
T4746	22468-22472	PR:000012318	denotes	PAX6
T4745	22431-22458	SO:0001587	denotes	premature termination codon
T4744	22301-22307	SO:0000417	denotes	domain
T4743	22220-22226	PR:000016642	denotes	TRIM11
T4742	22159-22165	SO:0000417	denotes	domain
T4741	22061-22067	PR:000016642	denotes	TRIM11
T4740	21760-21770	GO:0006412	denotes	translated
T4739	21755-21777	SO:0000205	denotes	3' untranslated region
T4738	21734-21745	GO:0006412	denotes	translation
T4737	21657-21662	PR:000002325	denotes	DNCL1
T4736	21646-21652	PR:000008680	denotes	HOMER3
T4735	21543-21548	PR:000002325	denotes	DNCL1
T4734	21532-21538	PR:000008680	denotes	HOMER3
T4733	21483-21487	PR:000012318	denotes	PAX6
T4732	21351-21355	PR:000012318	denotes	PAX6
T4731	21269-21274	PR:000002325	denotes	DNCL1
T4760	23284-23288	PR:000012318	denotes	PAX6
T4759	23267-23278	NCBITaxon:1	denotes	individuals
T4758	23239-23246	UBERON:0000966	denotes	retinal
T4757	23170-23174	PR:000012318	denotes	PAX6
T4756	23137-23143	UBERON:0000966	denotes	retina
R251	T555	T554	_lexicallyChainedTo	development,ocular
R252	T577	T576	_lexicallyChainedTo	prosencephalon-mesencephalon boundary,formation of
R253	T653	T652	_lexicallyChainedTo	gene,expression of
R1363	T2238	T2237	_lexicallyChainedTo	organelles,trafficking of
R2770	T4619	T4618	_lexicallyChainedTo	movement,microtubule-based
R2771	T4621	T4620	_lexicallyChainedTo	of proteins,movement
R2772	T4622	T4620	_lexicallyChainedTo	of,movement
R2773	T4623	T4622	_lexicallyChainedTo	vesicles,of
R4200	T6730	T6729	_lexicallyChainedTo	primer,reverse

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PMC:1208879 / 1518-31446 JSON TXT