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PMC:1208879 / 15113-15698 JSONTXT

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Id Subject Object Predicate Lexical cue
T3933 584-585 . denotes .
T3932 583-584 -RRB- denotes ]
T3931 580-581 , denotes ,
T3930 578-580 CD denotes 27
T3929 581-583 CD denotes 33
T3928 577-578 -LRB- denotes [
T3927 566-576 NN denotes hypoplasia
T3926 559-565 JJ denotes foveal
T3925 555-558 CC denotes and
T3924 546-554 NN denotes aniridia
T3923 538-545 JJ denotes typical
T3922 533-537 IN denotes with
T3921 529-532 CD denotes one
T3920 525-528 CC denotes and
T3919 515-524 NN denotes ectropion
T3918 509-514 JJ denotes uveal
T3917 504-508 IN denotes with
T3916 485-492 NN denotes segment
T3915 493-503 NN denotes dysgenesis
T3914 476-484 JJ denotes anterior
T3913 473-475 IN denotes by
T3912 464-472 VBN denotes affected
T3911 460-463 CD denotes one
T3910 458-460 , denotes ,
T3909 450-458 NNS denotes patients
T3908 446-449 CD denotes two
T3907 443-445 IN denotes in
T3906 429-433 VBN denotes been
T3905 425-428 VBZ denotes has
T3904 423-424 -RRB- denotes )
T3903 418-423 NN denotes Q422R
T3902 417-418 -LRB- denotes (
T3901 434-442 VBN denotes reported
T3900 399-407 JJ denotes missense
T3899 408-416 NN denotes mutation
T3898 394-398 DT denotes This
T3897 393-585 sentence denotes This missense mutation (Q422R) has been reported in two patients, one affected by anterior segment dysgenesis with uveal ectropion and one with typical aniridia and foveal hypoplasia [27,33].
T3896 392-393 . denotes .
T3895 388-392 NN denotes PAX6
T3894 385-387 IN denotes of
T3893 374-378 JJ denotes last
T3892 379-384 NN denotes codon
T3891 370-373 DT denotes the
T3890 367-369 IN denotes in
T3889 349-353 NN denotes acid
T3888 343-348 NN denotes amino
T3887 334-342 NN denotes arginine
T3886 331-333 IN denotes to
T3885 321-330 NN denotes glutamine
T3884 354-366 NN denotes substitution
T3883 319-320 DT denotes a
T3882 312-318 VBZ denotes causes
T3881 307-311 WDT denotes that
T3880 305-306 NN denotes G
T3879 304-305 SYM denotes >
T3878 299-304 NN denotes 1627A
T3877 275-285 NN denotes nucleotide
T3876 268-274 JJ denotes single
T3875 286-298 NN denotes substitution
T3874 266-267 DT denotes a
T3873 263-265 VBZ denotes is
T3872 248-253 JJ denotes first
T3871 254-262 NN denotes mutation
T3870 244-247 DT denotes The
T3869 243-393 sentence denotes The first mutation is a single nucleotide substitution 1627A>G that causes a glutamine to arginine amino acid substitution in the last codon of PAX6.
T3868 242-243 . denotes .
T3867 233-242 NNS denotes anomalies
T3866 226-232 JJ denotes ocular
T3865 221-225 IN denotes with
T3864 212-220 NNS denotes patients
T3863 209-211 IN denotes in
T3862 188-198 RB denotes previously
T3861 183-187 VBN denotes been
T3860 178-182 VBP denotes have
T3859 199-208 VBN denotes described
T3858 173-177 WDT denotes that
T3857 158-162 NN denotes PAX6
T3856 148-149 HYPH denotes -
T3855 149-157 JJ denotes terminal
T3854 147-148 NN denotes C
T3853 163-172 NNS denotes mutations
T3852 141-146 CD denotes three
T3851 138-140 IN denotes by
T3850 124-128 VBD denotes were
T3849 111-123 NNS denotes interactions
T3848 107-110 DT denotes the
T3847 129-137 VBN denotes affected
T3846 103-106 WRB denotes how
T3845 85-89 RB denotes next
T3844 82-84 PRP denotes we
T3843 80-82 , denotes ,
T3842 70-73 NN denotes PST
T3841 65-69 NN denotes PAX6
T3840 74-80 NN denotes domain
T3839 61-64 DT denotes the
T3838 56-60 IN denotes with
T3837 40-46 NN denotes TRIM11
T3836 36-39 CC denotes and
T3835 30-35 NN denotes DNCL1
T3823 9-10 JJ denotes n
T3822 7-9 NN denotes co
T3821 5-6 VBP denotes g
T3820 5-10 sentence denotes g con
T3819 3-5 NNS denotes in
T3818 2-3 CD denotes v
T3817 2-5 sentence denotes vin
T3816 1-2 VBG denotes a
T3815 0-1 NN denotes H
T3814 0-2 sentence denotes Ha
T3826 11-12 VBG denotes i
T3825 10-11 JJ denotes f
T3824 10-14 sentence denotes firm
T3834 28-30 , denotes ,
T3833 22-28 NN denotes HOMER3
T3832 47-55 VBP denotes interact
T3831 17-21 IN denotes that
T3830 90-102 VBD denotes investigated
T3829 14-16 VBN denotes ed
T3828 14-243 sentence denotes ed that HOMER3, DNCL1 and TRIM11 interact with the PAX6 PST domain, we next investigated how the interactions were affected by three C-terminal PAX6 mutations that have been previously described in patients with ocular anomalies.
T3827 12-14 JJ denotes rm
R2334 T3848 T3849 det the,interactions
R2335 T3849 T3847 nsubjpass interactions,affected
R2336 T3850 T3847 auxpass were,affected
R2337 T3851 T3847 agent by,affected
R2338 T3852 T3853 nummod three,mutations
R2339 T3853 T3851 pobj mutations,by
R2340 T3854 T3855 npadvmod C,terminal
R2341 T3855 T3853 amod terminal,mutations
R2342 T3856 T3855 punct -,terminal
R2343 T3857 T3853 compound PAX6,mutations
R2344 T3858 T3859 dep that,described
R2345 T3859 T3853 relcl described,mutations
R2346 T3860 T3859 aux have,described
R2347 T3861 T3859 auxpass been,described
R2348 T3862 T3859 advmod previously,described
R2349 T3863 T3859 prep in,described
R2350 T3864 T3863 pobj patients,in
R2351 T3865 T3864 prep with,patients
R2352 T3866 T3867 amod ocular,anomalies
R2353 T3867 T3865 pobj anomalies,with
R2354 T3868 T3830 punct .,investigated
R2355 T3870 T3871 det The,mutation
R2356 T3871 T3873 nsubj mutation,is
R2357 T3872 T3871 amod first,mutation
R2358 T3874 T3875 det a,substitution
R2359 T3875 T3873 attr substitution,is
R2360 T3876 T3875 amod single,substitution
R2361 T3877 T3875 compound nucleotide,substitution
R2362 T3878 T3875 appos 1627A,substitution
R2363 T3879 T3880 punct >,G
R2364 T3880 T3878 prep G,1627A
R2365 T3881 T3882 dep that,causes
R2366 T3882 T3875 relcl causes,substitution
R2367 T3883 T3884 det a,substitution
R2368 T3884 T3882 dobj substitution,causes
R2369 T3885 T3884 nmod glutamine,substitution
R2370 T3886 T3885 prep to,glutamine
R2371 T3887 T3886 pobj arginine,to
R2372 T3888 T3889 compound amino,acid
R2373 T3889 T3884 compound acid,substitution
R2374 T3890 T3882 prep in,causes
R2375 T3891 T3892 det the,codon
R2376 T3892 T3890 pobj codon,in
R2377 T3893 T3892 amod last,codon
R2378 T3894 T3892 prep of,codon
R2379 T3895 T3894 pobj PAX6,of
R2380 T3896 T3873 punct .,is
R2381 T3898 T3899 det This,mutation
R2382 T3899 T3901 nsubjpass mutation,reported
R2383 T3900 T3899 amod missense,mutation
R2384 T3902 T3899 punct (,mutation
R2385 T3903 T3899 appos Q422R,mutation
R2386 T3904 T3899 punct ),mutation
R2387 T3905 T3901 aux has,reported
R2388 T3906 T3901 auxpass been,reported
R2389 T3907 T3901 prep in,reported
R2390 T3908 T3909 nummod two,patients
R2391 T3909 T3907 pobj patients,in
R2392 T3910 T3909 punct ", ",patients
R2393 T3911 T3909 appos one,patients
R2394 T3912 T3911 acl affected,one
R2395 T3913 T3912 agent by,affected
R2396 T3914 T3915 amod anterior,dysgenesis
R2397 T3915 T3913 pobj dysgenesis,by
R2398 T3916 T3915 compound segment,dysgenesis
R2399 T3917 T3915 prep with,dysgenesis
R2400 T3918 T3919 amod uveal,ectropion
R2401 T3919 T3917 pobj ectropion,with
R2402 T3920 T3911 cc and,one
R2403 T3921 T3911 conj one,one
R2404 T3922 T3921 prep with,one
R2405 T3923 T3924 amod typical,aniridia
R2406 T3924 T3922 pobj aniridia,with
R2407 T3925 T3924 cc and,aniridia
R2408 T3926 T3927 amod foveal,hypoplasia
R2409 T3927 T3924 conj hypoplasia,aniridia
R2410 T3928 T3929 punct [,33
R2411 T3929 T3901 parataxis 33,reported
R2412 T3930 T3929 nummod 27,33
R2413 T3931 T3929 punct ",",33
R2414 T3932 T3929 punct ],33
R2415 T3933 T3901 punct .,reported
R2315 T3818 T3819 nummod v,in
R2316 T3829 T3830 advcl ed,investigated
R2317 T3831 T3832 mark that,interact
R2318 T3832 T3829 ccomp interact,ed
R2319 T3833 T3832 nsubj HOMER3,interact
R2320 T3834 T3833 punct ", ",HOMER3
R2321 T3835 T3833 conj DNCL1,HOMER3
R2322 T3836 T3835 cc and,DNCL1
R2323 T3837 T3835 conj TRIM11,DNCL1
R2324 T3838 T3832 prep with,interact
R2325 T3839 T3840 det the,domain
R2326 T3840 T3838 pobj domain,with
R2327 T3841 T3840 compound PAX6,domain
R2328 T3842 T3840 compound PST,domain
R2329 T3843 T3830 punct ", ",investigated
R2330 T3844 T3830 nsubj we,investigated
R2331 T3845 T3830 advmod next,investigated
R2332 T3846 T3847 advmod how,affected
R2333 T3847 T3830 ccomp affected,investigated

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3318 559-565 UBERON:0001786 denotes foveal
T3317 509-514 UBERON:0001768 denotes uveal
T3316 408-416 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3315 399-407 SO_EXT:missense_quality_or_entity denotes missense
T3314 388-392 PR_EXT:000012318 denotes PAX6
T3313 379-384 SO_EXT:0000360 denotes codon
T3312 354-366 SO_EXT:sequence_substitution_entity_or_process denotes substitution
T3311 343-353 CHEBI_SO_EXT:amino_acid denotes amino acid
T3310 334-342 CHEBI_SO_EXT:arginine denotes arginine
T3308 305-306 CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes G
T3307 286-298 SO_EXT:sequence_substitution_entity_or_process denotes substitution
T3294 0-1 PR_EXT:000008680 denotes H
T3309 321-330 CHEBI_SO_EXT:glutamine denotes glutamine
T3306 275-285 CHEBI_SO_EXT:nucleotide denotes nucleotide
T3305 254-262 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3304 226-232 UBERON:0000970 denotes ocular
T3303 163-172 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T3302 158-162 PR_EXT:000012318 denotes PAX6
T3301 147-157 CHEBI_SO_EXT:C_terminus_or_C_terminal_region denotes C-terminal
T3300 74-80 SO_EXT:0000417 denotes domain
T3299 65-69 PR_EXT:000012318 denotes PAX6
T3298 40-46 PR_EXT:000016642 denotes TRIM11
T3297 30-35 PR_EXT:000002325 denotes DNCL1
T3296 22-28 PR_EXT:000008680 denotes HOMER3
T3295 12-14 CHEBI_SO_EXT:N_terminus_or_N_terminal_region denotes rm

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3188 559-565 UBERON:0001786 denotes foveal
T3187 509-514 UBERON:0001768 denotes uveal
T3186 388-392 PR:000012318 denotes PAX6
T3185 379-384 SO:0000360 denotes codon
T3184 226-232 UBERON:0000970 denotes ocular
T3183 158-162 PR:000012318 denotes PAX6
T3182 74-80 SO:0000417 denotes domain
T3181 65-69 PR:000012318 denotes PAX6
T3180 40-46 PR:000016642 denotes TRIM11
T3179 30-35 PR:000002325 denotes DNCL1
T3178 22-28 PR:000008680 denotes HOMER3
T3177 0-1 PR:000008680 denotes H