PMC:1208879 / 1129-1516 JSONTXT

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    craft-sa-dev

    {"project":"craft-sa-dev","denotations":[{"id":"T384","span":{"begin":0,"end":10},"obj":"NN"},{"id":"T385","span":{"begin":10,"end":90},"obj":"sentence"},{"id":"T386","span":{"begin":11,"end":14},"obj":"PRP$"},{"id":"T387","span":{"begin":27,"end":31},"obj":"NNS"},{"id":"T388","span":{"begin":15,"end":26},"obj":"JJ"},{"id":"T389","span":{"begin":32,"end":39},"obj":"VBP"},{"id":"T390","span":{"begin":40,"end":44},"obj":"IN"},{"id":"T391","span":{"begin":50,"end":59},"obj":"VBZ"},{"id":"T392","span":{"begin":45,"end":49},"obj":"NN"},{"id":"T393","span":{"begin":60,"end":64},"obj":"IN"},{"id":"T394","span":{"begin":65,"end":71},"obj":"NN"},{"id":"T395","span":{"begin":71,"end":73},"obj":","},{"id":"T396","span":{"begin":73,"end":78},"obj":"NN"},{"id":"T397","span":{"begin":79,"end":82},"obj":"CC"},{"id":"T398","span":{"begin":83,"end":89},"obj":"NN"},{"id":"T399","span":{"begin":89,"end":90},"obj":"."},{"id":"T400","span":{"begin":90,"end":387},"obj":"sentence"},{"id":"T401","span":{"begin":91,"end":93},"obj":"PRP"},{"id":"T402","span":{"begin":94,"end":101},"obj":"VBP"},{"id":"T403","span":{"begin":102,"end":106},"obj":"IN"},{"id":"T404","span":{"begin":153,"end":155},"obj":"VBZ"},{"id":"T405","span":{"begin":107,"end":110},"obj":"DT"},{"id":"T406","span":{"begin":111,"end":122},"obj":"NN"},{"id":"T407","span":{"begin":123,"end":125},"obj":"IN"},{"id":"T408","span":{"begin":126,"end":130},"obj":"NN"},{"id":"T409","span":{"begin":131,"end":135},"obj":"IN"},{"id":"T410","span":{"begin":136,"end":142},"obj":"NN"},{"id":"T411","span":{"begin":143,"end":146},"obj":"CC"},{"id":"T412","span":{"begin":147,"end":152},"obj":"NN"},{"id":"T413","span":{"begin":156,"end":157},"obj":"DT"},{"id":"T414","span":{"begin":158,"end":167},"obj":"NN"},{"id":"T415","span":{"begin":168,"end":170},"obj":"IN"},{"id":"T416","span":{"begin":203,"end":207},"obj":"VB"},{"id":"T417","span":{"begin":171,"end":176},"obj":"WDT"},{"id":"T418","span":{"begin":177,"end":185},"obj":"JJ"},{"id":"T419","span":{"begin":186,"end":196},"obj":"NN"},{"id":"T420","span":{"begin":197,"end":202},"obj":"MD"},{"id":"T421","span":{"begin":208,"end":210},"obj":"IN"},{"id":"T422","span":{"begin":211,"end":218},"obj":"NNS"},{"id":"T423","span":{"begin":219,"end":221},"obj":"IN"},{"id":"T424","span":{"begin":222,"end":230},"obj":"JJ"},{"id":"T425","span":{"begin":247,"end":255},"obj":"NN"},{"id":"T426","span":{"begin":231,"end":246},"obj":"JJ"},{"id":"T427","span":{"begin":255,"end":257},"obj":","},{"id":"T428","span":{"begin":257,"end":260},"obj":"CC"},{"id":"T429","span":{"begin":261,"end":265},"obj":"IN"},{"id":"T430","span":{"begin":336,"end":345},"obj":"VBN"},{"id":"T431","span":{"begin":266,"end":270},"obj":"DT"},{"id":"T432","span":{"begin":271,"end":273},"obj":"IN"},{"id":"T433","span":{"begin":274,"end":277},"obj":"DT"},{"id":"T434","span":{"begin":285,"end":294},"obj":"NNS"},{"id":"T435","span":{"begin":278,"end":284},"obj":"JJ"},{"id":"T436","span":{"begin":295,"end":297},"obj":"IN"},{"id":"T437","span":{"begin":298,"end":306},"obj":"NNS"},{"id":"T438","span":{"begin":307,"end":311},"obj":"IN"},{"id":"T439","span":{"begin":312,"end":316},"obj":"NN"},{"id":"T440","span":{"begin":317,"end":326},"obj":"NNS"},{"id":"T441","span":{"begin":327,"end":332},"obj":"MD"},{"id":"T442","span":{"begin":333,"end":335},"obj":"VB"},{"id":"T443","span":{"begin":346,"end":348},"obj":"IN"},{"id":"T444","span":{"begin":349,"end":357},"obj":"JJ"},{"id":"T445","span":{"begin":374,"end":386},"obj":"NNS"},{"id":"T446","span":{"begin":358,"end":365},"obj":"NN"},{"id":"T447","span":{"begin":366,"end":373},"obj":"NN"},{"id":"T448","span":{"begin":365,"end":366},"obj":"SYM"},{"id":"T449","span":{"begin":386,"end":387},"obj":"."}],"relations":[{"id":"R189","pred":"nsubj","subj":"T387","obj":"T389"},{"id":"R190","pred":"amod","subj":"T388","obj":"T387"},{"id":"R192","pred":"ccomp","subj":"T391","obj":"T389"},{"id":"R193","pred":"nsubj","subj":"T392","obj":"T391"},{"id":"R203","pred":"advcl","subj":"T404","obj":"T402"},{"id":"R204","pred":"det","subj":"T405","obj":"T406"},{"id":"R205","pred":"nsubj","subj":"T406","obj":"T404"},{"id":"R206","pred":"prep","subj":"T407","obj":"T406"},{"id":"R207","pred":"pobj","subj":"T408","obj":"T407"},{"id":"R208","pred":"prep","subj":"T409","obj":"T406"},{"id":"R209","pred":"pobj","subj":"T410","obj":"T409"},{"id":"R210","pred":"cc","subj":"T411","obj":"T410"},{"id":"R211","pred":"conj","subj":"T412","obj":"T410"},{"id":"R215","pred":"relcl","subj":"T416","obj":"T414"},{"id":"R216","pred":"pobj","subj":"T417","obj":"T415"},{"id":"R217","pred":"amod","subj":"T418","obj":"T419"},{"id":"R218","pred":"nsubj","subj":"T419","obj":"T416"},{"id":"R219","pred":"aux","subj":"T420","obj":"T416"},{"id":"R224","pred":"pobj","subj":"T425","obj":"T423"},{"id":"R225","pred":"amod","subj":"T426","obj":"T425"},{"id":"R229","pred":"conj","subj":"T430","obj":"T404"},{"id":"R230","pred":"nsubjpass","subj":"T431","obj":"T430"},{"id":"R231","pred":"prep","subj":"T432","ob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preliminary data suggest that PAX6 interacts with HOMER3, DNCL1 and TRIM11. We propose that the interaction of PAX6 with HOMER3 and DNCL1 is a mechanism by which synaptic activation could lead to changes in neuronal transcriptional activity, and that some of the neural anomalies in patients with PAX6 mutations could be explained by impaired protein-protein interactions."}

    craft-ca-core-ex-dev

    {"project":"craft-ca-core-ex-dev","denotations":[{"id":"T161","span":{"begin":45,"end":49},"obj":"PR_EXT:000012318"},{"id":"T162","span":{"begin":65,"end":71},"obj":"PR_EXT:000008680"},{"id":"T163","span":{"begin":73,"end":78},"obj":"PR_EXT:000002325"},{"id":"T164","span":{"begin":83,"end":89},"obj":"PR_EXT:000016642"},{"id":"T165","span":{"begin":126,"end":130},"obj":"PR_EXT:000012318"},{"id":"T166","span":{"begin":136,"end":142},"obj":"PR_EXT:000008680"},{"id":"T167","span":{"begin":147,"end":152},"obj":"PR_EXT:000002325"},{"id":"T168","span":{"begin":177,"end":185},"obj":"GO:0045202"},{"id":"T169","span":{"begin":222,"end":230},"obj":"CL:0000540"},{"id":"T170","span":{"begin":231,"end":246},"obj":"GO_EXT:transcription"},{"id":"T171","span":{"begin":278,"end":284},"obj":"UBERON_EXT:neural_tissue_or_nerve_or_nervous_system"},{"id":"T172","span":{"begin":312,"end":316},"obj":"PR_EXT:000012318"},{"id":"T173","span":{"begin":317,"end":326},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T174","span":{"begin":358,"end":365},"obj":"CHEBI_PR_EXT:protein"},{"id":"T103","span":{"begin":366,"end":373},"obj":"CHEBI_PR_EXT:protein"}],"text":"Conclusion\nOur preliminary data suggest that PAX6 interacts with HOMER3, DNCL1 and TRIM11. We propose that the interaction of PAX6 with HOMER3 and DNCL1 is a mechanism by which synaptic activation could lead to changes in neuronal transcriptional activity, and that some of the neural anomalies in patients with PAX6 mutations could be explained by impaired protein-protein interactions."}

    craft-ca-core-dev

    {"project":"craft-ca-core-dev","denotations":[{"id":"T93","span":{"begin":45,"end":49},"obj":"PR:000012318"},{"id":"T94","span":{"begin":65,"end":71},"obj":"PR:000008680"},{"id":"T95","span":{"begin":73,"end":78},"obj":"PR:000002325"},{"id":"T96","span":{"begin":83,"end":89},"obj":"PR:000016642"},{"id":"T97","span":{"begin":126,"end":130},"obj":"PR:000012318"},{"id":"T98","span":{"begin":136,"end":142},"obj":"PR:000008680"},{"id":"T99","span":{"begin":147,"end":152},"obj":"PR:000002325"},{"id":"T100","span":{"begin":177,"end":185},"obj":"GO:0045202"},{"id":"T101","span":{"begin":222,"end":230},"obj":"CL:0000540"},{"id":"T102","span":{"begin":312,"end":316},"obj":"PR:000012318"}],"text":"Conclusion\nOur preliminary data suggest that PAX6 interacts with HOMER3, DNCL1 and TRIM11. We propose that the interaction of PAX6 with HOMER3 and DNCL1 is a mechanism by which synaptic activation could lead to changes in neuronal transcriptional activity, and that some of the neural anomalies in patients with PAX6 mutations could be explained by impaired protein-protein interactions."}