PMC:1208873 / 4267-4863 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T1301","span":{"begin":0,"end":8},"obj":"NN"},{"id":"T1302","span":{"begin":59,"end":66},"obj":"VBZ"},{"id":"T1303","span":{"begin":9,"end":11},"obj":"IN"},{"id":"T1304","span":{"begin":12,"end":22},"obj":"NN"},{"id":"T1305","span":{"begin":23,"end":32},"obj":"JJ"},{"id":"T1306","span":{"begin":51,"end":58},"obj":"NNS"},{"id":"T1307","span":{"begin":33,"end":39},"obj":"NN"},{"id":"T1308","span":{"begin":39,"end":40},"obj":"HYPH"},{"id":"T1309","span":{"begin":40,"end":41},"obj":"CD"},{"id":"T1310","span":{"begin":41,"end":42},"obj":"HYPH"},{"id":"T1311","span":{"begin":42,"end":48},"obj":"NN"},{"id":"T1312","span":{"begin":48,"end":49},"obj":"HYPH"},{"id":"T1313","span":{"begin":49,"end":50},"obj":"CD"},{"id":"T1314","span":{"begin":67,"end":71},"obj":"IN"},{"id":"T1315","span":{"begin":134,"end":140},"obj":"VB"},{"id":"T1316","span":{"begin":72,"end":82},"obj":"JJ"},{"id":"T1317","span":{"begin":83,"end":95},"obj":"NN"},{"id":"T1318","span":{"begin":96,"end":98},"obj":"IN"},{"id":"T1319","span":{"begin":99,"end":102},"obj":"DT"},{"id":"T1320","span":{"begin":112,"end":116},"obj":"NN"},{"id":"T1321","span":{"begin":103,"end":108},"obj":"NN"},{"id":"T1322","span":{"begin":109,"end":111},"obj":"NN"},{"id":"T1323","span":{"begin":117,"end":121},"obj":"VBZ"},{"id":"T1324","span":{"begin":122,"end":125},"obj":"RB"},{"id":"T1325","span":{"begin":126,"end":133},"obj":"RB"},{"id":"T1326","span":{"begin":141,"end":152},"obj":"NN"},{"id":"T1327","span":{"begin":153,"end":158},"obj":"IN"},{"id":"T1328","span":{"begin":159,"end":163},"obj":"NN"},{"id":"T1329","span":{"begin":163,"end":164},"obj":"."},{"id":"T1330","span":{"begin":164,"end":287},"obj":"sentence"},{"id":"T1331","span":{"begin":165,"end":167},"obj":"IN"},{"id":"T1332","span":{"begin":189,"end":196},"obj":"VBP"},{"id":"T1333","span":{"begin":168,"end":172},"obj":"NN"},{"id":"T1334","span":{"begin":172,"end":174},"obj":","},{"id":"T1335","span":{"begin":174,"end":180},"obj":"NN"},{"id":"T1336","span":{"begin":181,"end":188},"obj":"NNS"},{"id":"T1337","span":{"begin":197,"end":198},"obj":"DT"},{"id":"T1338","span":{"begin":219,"end":225},"obj":"NN"},{"id":"T1339","span":{"begin":199,"end":208},"obj":"VBN"},{"id":"T1340","span":{"begin":209,"end":218},"obj":"JJ"},{"id":"T1341","span":{"begin":225,"end":227},"obj":","},{"id":"T1342","span":{"begin":227,"end":234},"obj":"VBN"},{"id":"T1343","span":{"begin":235,"end":239},"obj":"NN"},{"id":"T1344","span":{"begin":240,"end":243},"obj":"CC"},{"id":"T1345","span":{"begin":243,"end":245},"obj":","},{"id":"T1346","span":{"begin":245,"end":247},"obj":"IN"},{"id":"T1347","span":{"begin":260,"end":264},"obj":"VBP"},{"id":"T1348","span":{"begin":248,"end":258},"obj":"NN"},{"id":"T1349","span":{"begin":258,"end":260},"obj":","},{"id":"T1350","span":{"begin":265,"end":266},"obj":"DT"},{"id":"T1351","span":{"begin":267,"end":271},"obj":"NN"},{"id":"T1352","span":{"begin":272,"end":275},"obj":"CC"},{"id":"T1353","span":{"begin":276,"end":280},"obj":"NN"},{"id":"T1354","span":{"begin":281,"end":286},"obj":"NNS"},{"id":"T1355","span":{"begin":286,"end":287},"obj":"."},{"id":"T1356","span":{"begin":287,"end":330},"obj":"sentence"},{"id":"T1357","span":{"begin":288,"end":295},"obj":"NNS"},{"id":"T1358","span":{"begin":308,"end":316},"obj":"VBN"},{"id":"T1359","span":{"begin":296,"end":299},"obj":"VBP"},{"id":"T1360","span":{"begin":300,"end":307},"obj":"RB"},{"id":"T1361","span":{"begin":317,"end":319},"obj":"IN"},{"id":"T1362","span":{"begin":320,"end":324},"obj":"NN"},{"id":"T1363","span":{"begin":325,"end":326},"obj":"-LRB-"},{"id":"T1364","span":{"begin":326,"end":328},"obj":"CD"},{"id":"T1365","span":{"begin":328,"end":329},"obj":"-RRB-"},{"id":"T1366","span":{"begin":329,"end":330},"obj":"."},{"id":"T1367","span":{"begin":330,"end":596},"obj":"sentence"},{"id":"T1368","span":{"begin":331,"end":342},"obj":"RB"},{"id":"T1369","span":{"begin":416,"end":423},"obj":"VBZ"},{"id":"T1370","span":{"begin":342,"end":344},"obj":","},{"id":"T1371","span":{"begin":344,"end":347},"obj":"DT"},{"id":"T1372","span":{"begin":348,"end":358},"obj":"NN"},{"id":"T1373","span":{"begin":359,"end":361},"obj":"IN"},{"id":"T1374","span":{"begin":362,"end":372},"obj":"NN"},{"id":"T1375","span":{"begin":373,"end":377},"obj":"RB"},{"id":"T1376","span":{"begin":378,"end":380},"obj":"IN"},{"id":"T1377","span":{"begin":381,"end":395},"obj":"JJ"},{"id":"T1378","span":{"begin":396,"end":403},"obj":"NNS"},{"id":"T1379","span":{"begin":404,"end":406},"obj":"IN"},{"id":"T1380","span":{"begin":407,"end":415},"obj":"NNS"},{"id":"T1381","span":{"begin":424,"end":428},"obj":"DT"},{"id":"T1382","span":{"begin":442,"end":451},"obj":"NN"},{"id":"T1383","span":{"begin":429,"end":441},"obj":"NN"},{"id":"T1384","span":{"begin":451,"end":453},"obj":","},{"id":"T1385","span":{"begin":453,"end":463},"obj":"VBG"},{"id":"T1386","span":{"begin":464,"end":468},"obj":"IN"},{"id":"T1387","span":{"begin":483,"end":491},"obj":"VBN"},{"id":"T1388","span":{"begin":469,"end":479},"obj":"NN"},{"id":"T1389","span":{"begin":480,"end":482},"obj":"VBZ"},{"id":"T1390","span":{"begin":492,"end":496},"obj":"RB"},{"id":"T1391","span":{"begin":497,"end":499},"obj":"IN"},{"id":"T1392","span":{"begin":500,"end":505},"obj":"NNS"},{"id":"T1393","span":{"begin":506,"end":508},"obj":"IN"},{"id":"T1394","span":{"begin":509,"end":512},"obj":"DT"},{"id":"T1395","span":{"begin":528,"end":535},"obj":"NN"},{"id":"T1396","span":{"begin":513,"end":527},"obj":"JJ"},{"id":"T1397","span":{"begin":536,"end":539},"obj":"CC"},{"id":"T1398","span":{"begin":540,"end":544},"obj":"VBZ"},{"id":"T1399","span":{"begin":545,"end":547},"obj":"IN"},{"id":"T1400","span":{"begin":548,"end":549},"obj":"DT"},{"id":"T1401","span":{"begin":570,"end":576},"obj":"NN"},{"id":"T1402","span":{"begin":550,"end":554},"obj":"NN"},{"id":"T1403","span":{"begin":555,"end":569},"obj":"JJ"},{"id":"T1404","span":{"begin":577,"end":579},"obj":"IN"},{"id":"T1405","span":{"begin":580,"end":584},"obj":"DT"},{"id":"T1406","span":{"begin":585,"end":590},"obj":"NN"},{"id":"T1407","span":{"begin":591,"end":592},"obj":"-LRB-"},{"id":"T1408","span":{"begin":592,"end":594},"obj":"CD"},{"id":"T1409","span":{"begin":594,"end":595},"obj":"-RRB-"},{"id":"T1410","span":{"begin":595,"end":596},"obj":"."}],"relations":[{"id":"R689","pred":"nsubj","subj":"T1301","obj":"T1302"},{"id":"R690","pred":"prep","subj":"T1303","obj":"T1301"},{"id":"R691","pred":"npadvmod","subj":"T1304","obj":"T1305"},{"id":"R692","pred":"amod","subj":"T1305","obj":"T1306"},{"id":"R693","pred":"pobj","subj":"T1306","obj":"T1303"},{"id":"R694","pred":"nmod","subj":"T1307","obj":"T1306"},{"id":"R695","pred":"punct","subj":"T1308","obj":"T1307"},{"id":"R696","pred":"nummod","subj":"T1309","obj":"T1307"},{"id":"R697","pred":"punct","subj":"T1310","obj":"T1307"},{"id":"R698","pred":"appos","subj":"T1311","obj":"T1307"},{"id":"R699","pred":"punct","subj":"T1312","obj":"T1311"},{"id":"R700","pred":"nummod","subj":"T1313","obj":"T1311"},{"id":"R701","pred":"mark","subj":"T1314","obj":"T1315"},{"id":"R702","pred":"ccomp","subj":"T1315","obj":"T1302"},{"id":"R703","pred":"amod","subj":"T1316","obj":"T1317"},{"id":"R704","pred":"nsubj","subj":"T1317","obj":"T1315"},{"id":"R705","pred":"prep","subj":"T1318","obj":"T1317"},{"id":"R706","pred":"det","subj":"T1319","obj":"T1320"},{"id":"R707","pred":"pobj","subj":"T1320","obj":"T1318"},{"id":"R708","pred":"compound","subj":"T1321","obj":"T1320"},{"id":"R709","pred":"compound","subj":"T1322","obj":"T1320"},{"id":"R710","pred":"aux","subj":"T1323","obj":"T1315"},{"id":"R711","pred":"neg","subj":"T1324","obj":"T1315"},{"id":"R712","pred":"advmod","subj":"T1325","obj":"T1315"},{"id":"R713","pred":"dobj","subj":"T1326","obj":"T1315"},{"id":"R714","pred":"prep","subj":"T1327","obj":"T1315"},{"id":"R715","pred":"pobj","subj":"T1328","obj":"T1327"},{"id":"R716","pred":"punct","subj":"T1329","obj":"T1302"},{"id":"R717","pred":"prep","subj":"T1331","obj":"T1332"},{"id":"R718","pred":"pobj","subj":"T1333","obj":"T1331"},{"id":"R719","pred":"punct","subj":"T1334","obj":"T1332"},{"id":"R720","pred":"compound","subj":"T1335","obj":"T1336"},{"id":"R721","pred":"nsubj","subj":"T1336","obj":"T1332"},{"id":"R722","pred":"det","subj":"T1337","obj":"T1338"},{"id":"R723","pred":"dobj","subj":"T1338","obj":"T1332"},{"id":"R724","pred":"amod","subj":"T1339","obj":"T1338"},{"id":"R725","pred":"amod","subj":"T1340","obj":"T1338"},{"id":"R726","pred":"punct","subj":"T1341","obj":"T1338"},{"id":"R727","pred":"amod","subj":"T1342","obj":"T1343"},{"id":"R728","pred":"appos","subj":"T1343","obj":"T1338"},{"id":"R729","pred":"cc","subj":"T1344","obj":"T1332"},{"id":"R730","pred":"punct","subj":"T1345","obj":"T1332"},{"id":"R731","pred":"prep","subj":"T1346","obj":"T1347"},{"id":"R732","pred":"conj","subj":"T1347","obj":"T1332"},{"id":"R733","pred":"pobj","subj":"T1348","obj":"T1346"},{"id":"R734","pred":"punct","subj":"T1349","obj":"T1347"},{"id":"R735","pred":"det","subj":"T1350","obj":"T1351"},{"id":"R736","pred":"dobj","subj":"T1351","obj":"T1347"},{"id":"R737","pred":"cc","subj":"T1352","obj":"T1351"},{"id":"R738","pred":"compound","subj":"T1353","obj":"T1354"},{"id":"R739","pred":"conj","subj":"T1354","obj":"T1351"},{"id":"R740","pred":"punct","subj":"T1355","obj":"T1332"},{"id":"R741","pred":"nsubjpass","subj":"T1357","obj":"T1358"},{"id":"R742","pred":"auxpass","subj":"T1359","obj":"T1358"},{"id":"R743","pred":"advmod","subj":"T1360","obj":"T1358"},{"id":"R744","pred":"prep","subj":"T1361","obj":"T1358"},{"id":"R745","pred":"pobj","subj":"T1362","obj":"T1361"},{"id":"R746","pred":"punct","subj":"T1363","obj":"T1364"},{"id":"R747","pred":"parataxis","subj":"T1364","obj":"T1358"},{"id":"R748","pred":"punct","subj":"T1365","obj":"T1364"},{"id":"R749","pred":"punct","subj":"T1366","obj":"T1358"},{"id":"R750","pred":"advmod","subj":"T1368","obj":"T1369"},{"id":"R751","pred":"punct","subj":"T1370","obj":"T1369"},{"id":"R752","pred":"det","subj":"T1371","obj":"T1372"},{"id":"R753","pred":"nsubj","subj":"T1372","obj":"T1369"},{"id":"R754","pred":"prep","subj":"T1373","obj":"T1372"},{"id":"R755","pred":"pobj","subj":"T1374","obj":"T1373"},{"id":"R756","pred":"advmod","subj":"T1375","obj":"T1376"},{"id":"R757","pred":"prep","subj":"T1376","obj":"T1372"},{"id":"R758","pred":"amod","subj":"T1377","obj":"T1378"},{"id":"R759","pred":"pobj","subj":"T1378","obj":"T1376"},{"id":"R760","pred":"prep","subj":"T1379","obj":"T1372"},{"id":"R761","pred":"pobj","subj":"T1380","obj":"T1379"},{"id":"R762","pred":"det","subj":"T1381","obj":"T1382"},{"id":"R763","pred":"dobj","subj":"T1382","obj":"T1369"},{"id":"R764","pred":"compound","subj":"T1383","obj":"T1382"},{"id":"R765","pred":"punct","subj":"T1384","obj":"T1369"},{"id":"R766","pred":"advcl","subj":"T1385","obj":"T1369"},{"id":"R767","pred":"mark","subj":"T1386","obj":"T1387"},{"id":"R768","pred":"ccomp","subj":"T1387","obj":"T1385"},{"id":"R769","pred":"nsubjpass","subj":"T1388","obj":"T1387"},{"id":"R770","pred":"auxpass","subj":"T1389","obj":"T1387"},{"id":"R771","pred":"advmod","subj":"T1390","obj":"T1391"},{"id":"R772","pred":"prep","subj":"T1391","obj":"T1387"},{"id":"R773","pred":"pobj","subj":"T1392","obj":"T1391"},{"id":"R774","pred":"prep","subj":"T1393","obj":"T1392"},{"id":"R775","pred":"det","subj":"T1394","obj":"T1395"},{"id":"R776","pred":"pobj","subj":"T1395","obj":"T1393"},{"id":"R777","pred":"amod","subj":"T1396","obj":"T1395"},{"id":"R778","pred":"cc","subj":"T1397","obj":"T1387"},{"id":"R779","pred":"conj","subj":"T1398","obj":"T1387"},{"id":"R780","pred":"prep","subj":"T1399","obj":"T1398"},{"id":"R781","pred":"det","subj":"T1400","obj":"T1401"},{"id":"R782","pred":"pobj","subj":"T1401","obj":"T1399"},{"id":"R783","pred":"npadvmod","subj":"T1402","obj":"T1403"},{"id":"R784","pred":"amod","subj":"T1403","obj":"T1401"},{"id":"R785","pred":"prep","subj":"T1404","obj":"T1398"},{"id":"R786","pred":"det","subj":"T1405","obj":"T1406"},{"id":"R787","pred":"pobj","subj":"T1406","obj":"T1404"},{"id":"R788","pred":"punct","subj":"T1407","obj":"T1408"},{"id":"R789","pred":"parataxis","subj":"T1408","obj":"T1398"},{"id":"R790","pred":"punct","subj":"T1409","obj":"T1408"},{"id":"R791","pred":"punct","subj":"T1410","obj":"T1369"}],"text":"Analysis of huntingtin deficient Hdhex4/5/Hdhex4/5 embryos reveals that homozygous inactivation of the mouse HD gene does not overtly affect development until E7.0. By E7.5, mutant embryos exhibit a shortened primitive streak, reduced size and, by morphology, lack a node and head folds. Mutants are rapidly resorbed by E8.0 [10]. Importantly, the expression of huntingtin only in extraembryonic tissues in chimeras rescues this gastrulation phenotype, suggesting that huntingtin is required only in cells of the extraembryonic lineage and acts in a cell non-autonomous manner at this stage [16]."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T852","span":{"begin":12,"end":22},"obj":"PR_EXT:000008840"},{"id":"T853","span":{"begin":33,"end":36},"obj":"PR_EXT:000008840"},{"id":"T854","span":{"begin":42,"end":45},"obj":"PR_EXT:000008840"},{"id":"T855","span":{"begin":51,"end":58},"obj":"UBERON:0000922"},{"id":"T856","span":{"begin":103,"end":108},"obj":"NCBITaxon:10088"},{"id":"T857","span":{"begin":109,"end":111},"obj":"PR_EXT:000008840"},{"id":"T858","span":{"begin":112,"end":116},"obj":"SO_EXT:0000704"},{"id":"T859","span":{"begin":174,"end":180},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T860","span":{"begin":181,"end":188},"obj":"UBERON:0000922"},{"id":"T861","span":{"begin":209,"end":225},"obj":"UBERON:0004341"},{"id":"T862","span":{"begin":267,"end":271},"obj":"UBERON:0003062"},{"id":"T863","span":{"begin":276,"end":286},"obj":"UBERON:0009746"},{"id":"T864","span":{"begin":288,"end":295},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T865","span":{"begin":348,"end":358},"obj":"GO:0010467"},{"id":"T866","span":{"begin":362,"end":372},"obj":"PR_EXT:000008840"},{"id":"T867","span":{"begin":381,"end":403},"obj":"UBERON:0005292"},{"id":"T868","span":{"begin":416,"end":423},"obj":"SO_EXT:sequence_rescue_process"},{"id":"T869","span":{"begin":429,"end":441},"obj":"GO:0007369"},{"id":"T870","span":{"begin":469,"end":479},"obj":"PR_EXT:000008840"},{"id":"T871","span":{"begin":500,"end":505},"obj":"CL_GO_EXT:cell"},{"id":"T872","span":{"begin":518,"end":527},"obj":"UBERON:0000922"},{"id":"T873","span":{"begin":550,"end":554},"obj":"CL_GO_EXT:cell"}],"text":"Analysis of huntingtin deficient Hdhex4/5/Hdhex4/5 embryos reveals that homozygous inactivation of the mouse HD gene does not overtly affect development until E7.0. By E7.5, mutant embryos exhibit a shortened primitive streak, reduced size and, by morphology, lack a node and head folds. Mutants are rapidly resorbed by E8.0 [10]. Importantly, the expression of huntingtin only in extraembryonic tissues in chimeras rescues this gastrulation phenotype, suggesting that huntingtin is required only in cells of the extraembryonic lineage and acts in a cell non-autonomous manner at this stage [16]."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T719","span":{"begin":12,"end":22},"obj":"PR:000008840"},{"id":"T720","span":{"begin":33,"end":36},"obj":"PR:000008840"},{"id":"T721","span":{"begin":42,"end":45},"obj":"PR:000008840"},{"id":"T722","span":{"begin":51,"end":58},"obj":"UBERON:0000922"},{"id":"T723","span":{"begin":103,"end":108},"obj":"NCBITaxon:10088"},{"id":"T724","span":{"begin":109,"end":111},"obj":"PR:000008840"},{"id":"T725","span":{"begin":112,"end":116},"obj":"SO:0000704"},{"id":"T726","span":{"begin":181,"end":188},"obj":"UBERON:0000922"},{"id":"T727","span":{"begin":209,"end":225},"obj":"UBERON:0004341"},{"id":"T728","span":{"begin":267,"end":271},"obj":"UBERON:0003062"},{"id":"T729","span":{"begin":276,"end":286},"obj":"UBERON:0009746"},{"id":"T730","span":{"begin":348,"end":358},"obj":"GO:0010467"},{"id":"T731","span":{"begin":362,"end":372},"obj":"PR:000008840"},{"id":"T732","span":{"begin":381,"end":403},"obj":"UBERON:0005292"},{"id":"T733","span":{"begin":429,"end":441},"obj":"GO:0007369"},{"id":"T734","span":{"begin":469,"end":479},"obj":"PR:000008840"},{"id":"T735","span":{"begin":518,"end":527},"obj":"UBERON:0000922"}],"text":"Analysis of huntingtin deficient Hdhex4/5/Hdhex4/5 embryos reveals that homozygous inactivation of the mouse HD gene does not overtly affect development until E7.0. By E7.5, mutant embryos exhibit a shortened primitive streak, reduced size and, by morphology, lack a node and head folds. Mutants are rapidly resorbed by E8.0 [10]. Importantly, the expression of huntingtin only in extraembryonic tissues in chimeras rescues this gastrulation phenotype, suggesting that huntingtin is required only in cells of the extraembryonic lineage and acts in a cell non-autonomous manner at this stage [16]."}