PMC:1208873 / 3618-4266 JSONTXT

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    craft-sa-dev

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we, and others, set out to discover huntingtin's essential activities by studying the effects of huntingtin deficiency in the mouse. Inactivation of the mouse HD gene (Hdh) has shown that huntingtin is not required for cell viability, as evidenced by the survival of mouse embryonic stem cells and neurons that lack huntingtin [10-12]. However, huntingtin is needed at the level of the organism for proper mammalian embryonic development [10,13,14]. Complete lack of huntingtin results in developmental arrest during gastrulation, while severe reduction of huntingtin levels results in abnormal neurogenesis and perinatal lethality [15]."}

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    craft-ca-core-dev

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