PMC:1208873 / 24635-25410 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1208873","sourcedb":"PMC","sourceid":"1208873","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1208873","text":"We have investigated the embryonic processes that require huntingtin in order to more precisely delineate huntingtin's essential molecular and cellular activities and to provide clues to the mechanism by which the dominant polyglutamine expansion mutation in huntingtin leads to HD pathogenesis. In pursuing the finding that huntingtin is needed only in extraembryonic tissues for normal gastrulation, our data fail to provide evidence of abnormal nutritive gene expression in Hdhex4/5/Hdhex4/5 embryos. Instead, our results reveal that huntingtin is required for normal anterior streak formation and the consequent production of paraxial mesoderm, with a previously unrecognized role for huntingtin in the proper extinction of transiently and/or dynamically expressed genes.","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T6261","span":{"begin":0,"end":2},"obj":"PRP"},{"id":"T6262","span":{"begin":8,"end":20},"obj":"VBN"},{"id":"T6263","span":{"begin":3,"end":7},"obj":"VBP"},{"id":"T6264","span":{"begin":21,"end":24},"obj":"DT"},{"id":"T6265","span":{"begin":35,"end":44},"obj":"NNS"},{"id":"T6266","span":{"begin":25,"end":34},"obj":"JJ"},{"id":"T6267","span":{"begin":45,"end":49},"obj":"WDT"},{"id":"T6268","span":{"begin":50,"end":57},"obj":"VBP"},{"id":"T6269","span":{"begin":58,"end":68},"obj":"NN"},{"id":"T6270","span":{"begin":69,"end":71},"obj":"IN"},{"id":"T6271","span":{"begin":72,"end":77},"obj":"NN"},{"id":"T6272","span":{"begin":78,"end":80},"obj":"TO"},{"id":"T6273","span":{"begin":96,"end":105},"obj":"VB"},{"id":"T6274","span":{"begin":81,"end":85},"obj":"RBR"},{"id":"T6275","span":{"begin":86,"end":95},"obj":"RB"},{"id":"T6276","span":{"begin":106,"end":116},"obj":"NN"},{"id":"T6277","span":{"begin":152,"end":162},"obj":"NNS"},{"id":"T6278","span":{"begin":116,"end":118},"obj":"POS"},{"id":"T6279","span":{"begin":119,"end":128},"obj":"JJ"},{"id":"T6280","span":{"begin":129,"end":138},"obj":"JJ"},{"id":"T6281","span":{"begin":139,"end":142},"obj":"CC"},{"id":"T6282","span":{"begin":143,"end":151},"obj":"JJ"},{"id":"T6283","span":{"begin":163,"end":166},"obj":"CC"},{"id":"T6284","span":{"begin":167,"end":169},"obj":"TO"},{"id":"T6285","span":{"begin":170,"end":177},"obj":"VB"},{"id":"T6286","span":{"begin":178,"end":183},"obj":"NNS"},{"id":"T6287","span":{"begin":184,"end":186},"obj":"IN"},{"id":"T6288","span":{"begin":187,"end":190},"obj":"DT"},{"id":"T6289","span":{"begin":191,"end":200},"obj":"NN"},{"id":"T6290","span":{"begin":201,"end":203},"obj":"IN"},{"id":"T6291","span":{"begin":270,"end":275},"obj":"VBZ"},{"id":"T6292","span":{"begin":204,"end":209},"obj":"WDT"},{"id":"T6293","span":{"begin":210,"end":213},"obj":"DT"},{"id":"T6294","span":{"begin":247,"end":255},"obj":"NN"},{"id":"T6295","span":{"begin":214,"end":222},"obj":"JJ"},{"id":"T6296","span":{"begin":223,"end":236},"obj":"NN"},{"id":"T6297","span":{"begin":237,"end":246},"obj":"NN"},{"id":"T6298","span":{"begin":256,"end":258},"obj":"IN"},{"id":"T6299","span":{"begin":259,"end":269},"obj":"NN"},{"id":"T6300","span":{"begin":276,"end":278},"obj":"IN"},{"id":"T6301","span":{"begin":279,"end":281},"obj":"NN"},{"id":"T6302","span":{"begin":282,"end":294},"obj":"NN"},{"id":"T6303","span":{"begin":294,"end":295},"obj":"."},{"id":"T6304","span":{"begin":295,"end":503},"obj":"sentence"},{"id":"T6305","span":{"begin":296,"end":298},"obj":"IN"},{"id":"T6306","span":{"begin":411,"end":415},"obj":"VBP"},{"id":"T6307","span":{"begin":299,"end":307},"obj":"VBG"},{"id":"T6308","span":{"begin":308,"end":311},"obj":"DT"},{"id":"T6309","span":{"begin":312,"end":319},"obj":"NN"},{"id":"T6310","span":{"begin":320,"end":324},"obj":"IN"},{"id":"T6311","span":{"begin":339,"end":345},"obj":"VBN"},{"id":"T6312","span":{"begin":325,"end":335},"obj":"NN"},{"id":"T6313","span":{"begin":336,"end":338},"obj":"VBZ"},{"id":"T6314","span":{"begin":346,"end":350},"obj":"RB"},{"id":"T6315","span":{"begin":351,"end":353},"obj":"IN"},{"id":"T6316","span":{"begin":354,"end":368},"obj":"JJ"},{"id":"T6317","span":{"begin":369,"end":376},"obj":"NNS"},{"id":"T6318","span":{"begin":377,"end":380},"obj":"IN"},{"id":"T6319","span":{"begin":381,"end":387},"obj":"JJ"},{"id":"T6320","span":{"begin":388,"end":400},"obj":"NN"},{"id":"T6321","span":{"begin":400,"end":402},"obj":","},{"id":"T6322","span":{"begin":402,"end":405},"obj":"PRP$"},{"id":"T6323","span":{"begin":406,"end":410},"obj":"NNS"},{"id":"T6324","span":{"begin":416,"end":418},"obj":"TO"},{"id":"T6325","span":{"begin":419,"end":426},"obj":"VB"},{"id":"T6326","span":{"begin":427,"end":435},"obj":"NN"},{"id":"T6327","span":{"begin":436,"end":438},"obj":"IN"},{"id":"T6328","span":{"begin":439,"end":447},"obj":"JJ"},{"id":"T6329","span":{"begin":463,"end":473},"obj":"NN"},{"id":"T6330","span":{"begin":448,"end":457},"obj":"NN"},{"id":"T6331","span":{"begin":458,"end":462},"obj":"NN"},{"id":"T6332","span":{"begin":474,"end":476},"obj":"IN"},{"id":"T6333","span":{"begin":477,"end":483},"obj":"NN"},{"id":"T6334","span":{"begin":495,"end":502},"obj":"NNS"},{"id":"T6335","span":{"begin":483,"end":484},"obj":"HYPH"},{"id":"T6336","span":{"begin":484,"end":485},"obj":"CD"},{"id":"T6337","span":{"begin":485,"end":486},"obj":"HYPH"},{"id":"T6338","span":{"begin":486,"end":492},"obj":"NN"},{"id":"T6339","span":{"begin":492,"end":493},"obj":"HYPH"},{"id":"T6340","span":{"begin":493,"end":494},"obj":"CD"},{"id":"T6341","span":{"begin":502,"end":503},"obj":"."},{"id":"T6342","span":{"begin":503,"end":775},"obj":"sentence"},{"id":"T6343","span":{"begin":504,"end":511},"obj":"RB"},{"id":"T6344","span":{"begin":525,"end":531},"obj":"VBP"},{"id":"T6345","span":{"begin":511,"end":513},"obj":","},{"id":"T6346","span":{"begin":513,"end":516},"obj":"PRP$"},{"id":"T6347","span":{"begin":517,"end":524},"obj":"NNS"},{"id":"T6348","span":{"begin":532,"end":536},"obj":"IN"},{"id":"T6349","span":{"begin":551,"end":559},"obj":"VBN"},{"id":"T6350","span":{"begin":537,"end":547},"obj":"NN"},{"id":"T6351","span":{"begin":548,"end":550},"obj":"VBZ"},{"id":"T6352","span":{"begin":560,"end":563},"obj":"IN"},{"id":"T6353","span":{"begin":564,"end":570},"obj":"JJ"},{"id":"T6354","span":{"begin":587,"end":596},"obj":"NN"},{"id":"T6355","span":{"begin":571,"end":579},"obj":"JJ"},{"id":"T6356","span":{"begin":580,"end":586},"obj":"NN"},{"id":"T6357","span":{"begin":597,"end":600},"obj":"CC"},{"id":"T6358","span":{"begin":601,"end":604},"obj":"DT"},{"id":"T6359","span":{"begin":616,"end":626},"obj":"NN"},{"id":"T6360","span":{"begin":605,"end":615},"obj":"JJ"},{"id":"T6361","span":{"begin":627,"end":629},"obj":"IN"},{"id":"T6362","span":{"begin":630,"end":638},"obj":"JJ"},{"id":"T6363","span":{"begin":639,"end":647},"obj":"NN"},{"id":"T6364","span":{"begin":647,"end":649},"obj":","},{"id":"T6365","span":{"begin":649,"end":653},"obj":"IN"},{"id":"T6366","span":{"begin":654,"end":655},"obj":"DT"},{"id":"T6367","span":{"begin":680,"end":684},"obj":"NN"},{"id":"T6368","span":{"begin":656,"end":666},"obj":"RB"},{"id":"T6369","span":{"begin":667,"end":679},"obj":"JJ"},{"id":"T6370","span":{"begin":685,"end":688},"obj":"IN"},{"id":"T6371","span":{"begin":689,"end":699},"obj":"NN"},{"id":"T6372","span":{"begin":700,"end":702},"obj":"IN"},{"id":"T6373","span":{"begin":703,"end":706},"obj":"DT"},{"id":"T6374","span":{"begin":714,"end":724},"obj":"NN"},{"id":"T6375","span":{"begin":707,"end":713},"obj":"JJ"},{"id":"T6376","span":{"begin":725,"end":727},"obj":"IN"},{"id":"T6377","span":{"begin":728,"end":739},"obj":"RB"},{"id":"T6378","span":{"begin":759,"end":768},"obj":"VBN"},{"id":"T6379","span":{"begin":740,"end":743},"obj":"CC"},{"id":"T6380","span":{"begin":743,"end":744},"obj":"HYPH"},{"id":"T6381","span":{"begin":744,"end":746},"obj":"CC"},{"id":"T6382","span":{"begin":747,"end":758},"obj":"RB"},{"id":"T6383","span":{"begin":769,"end":774},"obj":"NNS"},{"id":"T6384","span":{"begin":774,"end":775},"obj":"."}],"relations":[{"id":"R3408","pred":"nsubj","subj":"T6261","obj":"T6262"},{"id":"R3409","pred":"aux","subj":"T6263","obj":"T6262"},{"id":"R3410","pred":"det","subj":"T6264","obj":"T6265"},{"id":"R3411","pred":"dobj","subj":"T6265","obj":"T6262"},{"id":"R3412","pred":"amod","subj":"T6266","obj":"T6265"},{"id":"R3413","pred":"dep","subj":"T6267","obj":"T6268"},{"id":"R3414","pred":"relcl","subj":"T6268","obj":"T6265"},{"id":"R3415","pred":"dobj","subj":"T6269","obj":"T6268"},{"id":"R3416","pred":"prep","subj":"T6270","obj":"T6268"},{"id":"R3417","pred":"pobj","subj":"T6271","obj":"T6270"},{"id":"R3418","pred":"aux","subj":"T6272","obj":"T6273"},{"id":"R3419","pred":"acl","subj":"T6273","obj":"T6271"},{"id":"R3420","pred":"advmod","subj":"T6274","obj":"T6275"},{"id":"R3421","pred":"advmod","subj":"T6275","obj":"T6273"},{"id":"R3422","pred":"poss","subj":"T6276","obj":"T6277"},{"id":"R3423","pred":"dobj","subj":"T6277","obj":"T6273"},{"id":"R3424","pred":"case","subj":"T6278","obj":"T6276"},{"id":"R3425","pred":"amod","subj":"T6279","obj":"T6277"},{"id":"R3426","pred":"amod","subj":"T6280","obj":"T6277"},{"id":"R3427","pred":"cc","subj":"T6281","obj":"T6280"},{"id":"R3428","pred":"conj","subj":"T6282","obj":"T6280"},{"id":"R3429","pred":"cc","subj":"T6283","obj":"T6273"},{"id":"R3430","pred":"aux","subj":"T6284","obj":"T6285"},{"id":"R3431","pred":"conj","subj":"T6285","obj":"T6273"},{"id":"R3432","pred":"dobj","subj":"T6286","obj":"T6285"},{"id":"R3433","pred":"prep","subj":"T6287","obj":"T6286"},{"id":"R3434","pred":"det","subj":"T6288","obj":"T6289"},{"id":"R3435","pred":"pobj","subj":"T6289","obj":"T6287"},{"id":"R3436","pred":"prep","subj":"T6290","obj":"T6291"},{"id":"R3437","pred":"relcl","subj":"T6291","obj":"T6289"},{"id":"R3438","pred":"pobj","subj":"T6292","obj":"T6290"},{"id":"R3439","pred":"det","subj":"T6293","obj":"T6294"},{"id":"R3440","pred":"nsubj","subj":"T6294","obj":"T6291"},{"id":"R3441","pred":"amod","subj":"T6295","obj":"T6294"},{"id":"R3442","pred":"compound","subj":"T6296","obj":"T6297"},{"id":"R3443","pred":"compound","subj":"T6297","obj":"T6294"},{"id":"R3444","pred":"prep","subj":"T6298","obj":"T6294"},{"id":"R3445","pred":"pobj","subj":"T6299","obj":"T6298"},{"id":"R3446","pred":"prep","subj":"T6300","obj":"T6291"},{"id":"R3447","pred":"compound","subj":"T6301","obj":"T6302"},{"id":"R3448","pred":"pobj","subj":"T6302","obj":"T6300"},{"id":"R3449","pred":"punct","subj":"T6303","obj":"T6262"},{"id":"R3450","pred":"prep","subj":"T6305","obj":"T6306"},{"id":"R3451","pred":"pcomp","subj":"T6307","obj":"T6305"},{"id":"R3452","pred":"det","subj":"T6308","obj":"T6309"},{"id":"R3453","pred":"dobj","subj":"T6309","obj":"T6307"},{"id":"R3454","pred":"mark","subj":"T6310","obj":"T6311"},{"id":"R3455","pred":"acl","subj":"T6311","obj":"T6309"},{"id":"R3456","pred":"nsubjpass","subj":"T6312","obj":"T6311"},{"id":"R3457","pred":"auxpass","subj":"T6313","obj":"T6311"},{"id":"R3458","pred":"advmod","subj":"T6314","obj":"T6315"},{"id":"R3459","pred":"prep","subj":"T6315","obj":"T6311"},{"id":"R3460","pred":"amod","subj":"T6316","obj":"T6317"},{"id":"R3461","pred":"pobj","subj":"T6317","obj":"T6315"},{"id":"R3462","pred":"prep","subj":"T6318","obj":"T6311"},{"id":"R3463","pred":"amod","subj":"T6319","obj":"T6320"},{"id":"R3464","pred":"pobj","subj":"T6320","obj":"T6318"},{"id":"R3465","pred":"punct","subj":"T6321","obj":"T6306"},{"id":"R3466","pred":"poss","subj":"T6322","obj":"T6323"},{"id":"R3467","pred":"nsubj","subj":"T6323","obj":"T6306"},{"id":"R3468","pred":"aux","subj":"T6324","obj":"T6325"},{"id":"R3469","pred":"xcomp","subj":"T6325","obj":"T6306"},{"id":"R3470","pred":"dobj","subj":"T6326","obj":"T6325"},{"id":"R3471","pred":"prep","subj":"T6327","obj":"T6326"},{"id":"R3472","pred":"amod","subj":"T6328","obj":"T6329"},{"id":"R3473","pred":"pobj","subj":"T6329","obj":"T6327"},{"id":"R3474","pred":"compound","subj":"T6330","obj":"T6331"},{"id":"R3475","pred":"compound","subj":"T6331","obj":"T6329"},{"id":"R3476","pred":"prep","subj":"T6332","obj":"T6329"},{"id":"R3477","pred":"nmod","subj":"T6333","obj":"T6334"},{"id":"R3478","pred":"pobj","subj":"T6334","obj":"T6332"},{"id":"R3479","pred":"punct","subj":"T6335","obj":"T6333"},{"id":"R3480","pred":"nummod","subj":"T6336","obj":"T6333"},{"id":"R3481","pred":"punct","subj":"T6337","obj":"T6333"},{"id":"R3482","pred":"appos","subj":"T6338","obj":"T6333"},{"id":"R3483","pred":"punct","subj":"T6339","obj":"T6338"},{"id":"R3484","pred":"nummod","subj":"T6340","obj":"T6338"},{"id":"R3485","pred":"punct","subj":"T6341","obj":"T6306"},{"id":"R3486","pred":"advmod","subj":"T6343","obj":"T6344"},{"id":"R3487","pred":"punct","subj":"T6345","obj":"T6344"},{"id":"R3488","pred":"poss","subj":"T6346","obj":"T6347"},{"id":"R3489","pred":"nsubj","subj":"T6347","obj":"T6344"},{"id":"R3490","pred":"mark","subj":"T6348","obj":"T6349"},{"id":"R3491","pred":"ccomp","subj":"T6349","obj":"T6344"},{"id":"R3492","pred":"nsubjpass","subj":"T6350","obj":"T6349"},{"id":"R3493","pred":"auxpass","subj":"T6351","obj":"T6349"},{"id":"R3494","pred":"prep","subj":"T6352","obj":"T6349"},{"id":"R3495","pred":"amod","subj":"T6353","obj":"T6354"},{"id":"R3496","pred":"pobj","subj":"T6354","obj":"T6352"},{"id":"R3497","pred":"amod","subj":"T6355","obj":"T6356"},{"id":"R3498","pred":"compound","subj":"T6356","obj":"T6354"},{"id":"R3499","pred":"cc","subj":"T6357","obj":"T6354"},{"id":"R3500","pred":"det","subj":"T6358","obj":"T6359"},{"id":"R3501","pred":"conj","subj":"T6359","obj":"T6354"},{"id":"R3502","pred":"amod","subj":"T6360","obj":"T6359"},{"id":"R3503","pred":"prep","subj":"T6361","obj":"T6359"},{"id":"R3504","pred":"amod","subj":"T6362","obj":"T6363"},{"id":"R3505","pred":"pobj","subj":"T6363","obj":"T6361"},{"id":"R3506","pred":"punct","subj":"T6364","obj":"T6349"},{"id":"R3507","pred":"prep","subj":"T6365","obj":"T6349"},{"id":"R3508","pred":"det","subj":"T6366","obj":"T6367"},{"id":"R3509","pred":"pobj","subj":"T6367","obj":"T6365"},{"id":"R3510","pred":"advmod","subj":"T6368","obj":"T6369"},{"id":"R3511","pred":"amod","subj":"T6369","obj":"T6367"},{"id":"R3512","pred":"prep","subj":"T6370","obj":"T6367"},{"id":"R3513","pred":"pobj","subj":"T6371","obj":"T6370"},{"id":"R3514","pred":"prep","subj":"T6372","obj":"T6367"},{"id":"R3515","pred":"det","subj":"T6373","obj":"T6374"},{"id":"R3516","pred":"pobj","subj":"T6374","obj":"T6372"},{"id":"R3517","pred":"amod","subj":"T6375","obj":"T6374"},{"id":"R3518","pred":"prep","subj":"T6376","obj":"T6374"},{"id":"R3519","pred":"advmod","subj":"T6377","obj":"T6378"},{"id":"R3520","pred":"amod","subj":"T6378","obj":"T6383"},{"id":"R3521","pred":"cc","subj":"T6379","obj":"T6377"},{"id":"R3522","pred":"punct","subj":"T6380","obj":"T6379"},{"id":"R3523","pred":"cc","subj":"T6381","obj":"T6379"},{"id":"R3524","pred":"conj","subj":"T6382","obj":"T6377"},{"id":"R3525","pred":"pobj","subj":"T6383","obj":"T6376"},{"id":"R3526","pred":"punct","subj":"T6384","obj":"T6344"}],"attributes":[{"subj":"T6261","pred":"source","obj":"craft-sa-dev"},{"subj":"T6262","pred":"source","obj":"craft-sa-dev"},{"subj":"T6263","pred":"source","obj":"craft-sa-dev"},{"subj":"T6264","pred":"source","obj":"craft-sa-dev"},{"subj":"T6265","pred":"source","obj":"craft-sa-dev"},{"subj":"T6266","pred":"source","obj":"craft-sa-dev"},{"subj":"T6267","pred":"source","obj":"craft-sa-dev"},{"subj":"T6268","pred":"source","obj":"craft-sa-dev"},{"subj":"T6269","pred":"source","obj":"craft-sa-dev"},{"subj":"T6270","pred":"source","obj":"craft-sa-dev"},{"subj":"T6271","pred":"source","obj":"craft-sa-dev"},{"subj":"T6272","pred":"source","obj":"craft-sa-dev"},{"subj":"T6273","pred":"source","obj":"craft-sa-dev"},{"subj":"T6274","pred":"source","obj":"craft-sa-dev"},{"subj":"T6275","pred":"source","obj":"craft-sa-dev"},{"subj":"T6276","pred":"source","obj":"craft-sa-dev"},{"subj":"T6277","pred":"source","obj":"craft-sa-dev"},{"subj":"T6278","pred":"source","obj":"craft-sa-dev"},{"subj":"T6279","pred":"source","obj":"craft-sa-dev"},{"subj":"T6280","pred":"source","obj":"craft-sa-dev"},{"subj":"T6281","pred":"source","obj":"craft-sa-dev"},{"subj":"T6282","pred":"source","obj":"craft-sa-dev"},{"subj":"T6283","pred":"source","obj":"craft-sa-dev"},{"subj":"T6284","pred":"source","obj":"craft-sa-dev"},{"subj":"T6285","pred":"source","obj":"craft-sa-dev"},{"subj":"T6286","pred":"source","obj":"craft-sa-dev"},{"subj":"T6287","pred":"source","obj":"craft-sa-dev"},{"subj":"T6288","pred":"source","obj":"craft-sa-dev"},{"subj":"T6289","pred":"source","obj":"craft-sa-dev"},{"subj":"T6290","pred":"source","obj":"craft-sa-dev"},{"subj":"T6291","pred":"source","obj":"craft-sa-dev"},{"subj":"T6292","pred":"source","obj":"craft-sa-dev"},{"subj":"T6293","pred":"source","obj":"craft-sa-dev"},{"subj":"T6294","pred":"source","obj":"craft-sa-dev"},{"subj":"T6295","pred":"source","obj":"craft-sa-dev"},{"subj":"T6296","pred":"source","obj":"craft-sa-dev"},{"subj":"T6297","pred":"source","obj":"craft-sa-dev"},{"subj":"T6298","pred":"source","obj":"craft-sa-dev"},{"subj":"T6299","pred":"source","obj":"craft-sa-dev"},{"subj":"T6300","pred":"source","obj":"craft-sa-dev"},{"subj":"T6301","pred":"source","obj":"craft-sa-dev"},{"subj":"T6302","pred":"source","obj":"craft-sa-dev"},{"subj":"T6303","pred":"source","obj":"craft-sa-dev"},{"subj":"T6304","pred":"source","obj":"craft-sa-dev"},{"subj":"T6305","pred":"source","obj":"craft-sa-dev"},{"subj":"T6306","pred":"source","obj":"craft-sa-dev"},{"subj":"T6307","pred":"source","obj":"craft-sa-dev"},{"subj":"T6308","pred":"source","obj":"craft-sa-dev"},{"subj":"T6309","pred":"source","obj":"craft-sa-dev"},{"subj":"T6310","pred":"source","obj":"craft-sa-dev"},{"subj":"T6311","pred":"source","obj":"craft-sa-dev"},{"subj":"T6312","pred":"source","obj":"craft-sa-dev"},{"subj":"T6313","pred":"source","obj":"craft-sa-dev"},{"subj":"T6314","pred":"source","obj":"craft-sa-dev"},{"subj":"T6315","pred":"source","obj":"craft-sa-dev"},{"subj":"T6316","pred":"source","obj":"craft-sa-dev"},{"subj":"T6317","pred":"source","obj":"craft-sa-dev"},{"subj":"T6318","pred":"source","obj":"craft-sa-dev"},{"subj":"T6319","pred":"source","obj":"craft-sa-dev"},{"subj":"T6320","pred":"source","obj":"craft-sa-dev"},{"subj":"T6321","pred":"source","obj":"craft-sa-dev"},{"subj":"T6322","pred":"source","obj":"craft-sa-dev"},{"subj":"T6323","pred":"source","obj":"craft-sa-dev"},{"subj":"T6324","pred":"source","obj":"craft-sa-dev"},{"subj":"T6325","pred":"source","obj":"craft-sa-dev"},{"subj":"T6326","pred":"source","obj":"craft-sa-dev"},{"subj":"T6327","pred":"source","obj":"craft-sa-dev"},{"subj":"T6328","pred":"source","obj":"craft-sa-dev"},{"subj":"T6329","pred":"source","obj":"craft-sa-dev"},{"subj":"T6330","pred":"source","obj":"craft-sa-dev"},{"subj":"T6331","pred":"source","obj":"craft-sa-dev"},{"subj":"T6332","pred":"source","obj":"craft-sa-dev"},{"subj":"T6333","pred":"source","obj":"craft-sa-dev"},{"subj":"T6334","pred":"source","obj":"craft-sa-dev"},{"subj":"T6335","pred":"source","obj":"craft-sa-dev"},{"subj":"T6336","pred":"source","obj":"craft-sa-dev"},{"subj":"T6337","pred":"source","obj":"craft-sa-dev"},{"subj":"T6338","pred":"source","obj":"craft-sa-dev"},{"subj":"T6339","pred":"source","obj":"craft-sa-dev"},{"subj":"T6340","pred":"source","obj":"craft-sa-dev"},{"subj":"T6341","pred":"source","obj":"craft-sa-dev"},{"subj":"T6342","pred":"source","obj":"craft-sa-dev"},{"subj":"T6343","pred":"source","obj":"craft-sa-dev"},{"subj":"T6344","pred":"source","obj":"craft-sa-dev"},{"subj":"T6345","pred":"source","obj":"craft-sa-dev"},{"subj":"T6346","pred":"source","obj":"craft-sa-dev"},{"subj":"T6347","pred":"source","obj":"craft-sa-dev"},{"subj":"T6348","pred":"source","obj":"craft-sa-dev"},{"subj":"T6349","pred":"source","obj":"craft-sa-dev"},{"subj":"T6350","pred":"source","obj":"craft-sa-dev"},{"subj":"T6351","pred":"source","obj":"craft-sa-dev"},{"subj":"T6352","pred":"source","obj":"craft-sa-dev"},{"subj":"T6353","pred":"source","obj":"craft-sa-dev"},{"subj":"T6354","pred":"source","obj":"craft-sa-dev"},{"subj":"T6355","pred":"source","obj":"craft-sa-dev"},{"subj":"T6356","pred":"source","obj":"craft-sa-dev"},{"subj":"T6357","pred":"source","obj":"craft-sa-dev"},{"subj":"T6358","pred":"source","obj":"craft-sa-dev"},{"subj":"T6359","pred":"source","obj":"craft-sa-dev"},{"subj":"T6360","pred":"source","obj":"craft-sa-dev"},{"subj":"T6361","pred":"source","obj":"craft-sa-dev"},{"subj":"T6362","pred":"source","obj":"craft-sa-dev"},{"subj":"T6363","pred":"source","obj":"craft-sa-dev"},{"subj":"T6364","pred":"source","obj":"craft-sa-dev"},{"subj":"T6365","pred":"source","obj":"craft-sa-dev"},{"subj":"T6366","pred":"source","obj":"craft-sa-dev"},{"subj":"T6367","pred":"source","obj":"craft-sa-dev"},{"subj":"T6368","pred":"source","obj":"craft-sa-dev"},{"subj":"T6369","pred":"source","obj":"craft-sa-dev"},{"subj":"T6370","pred":"source","obj":"craft-sa-dev"},{"subj":"T6371","pred":"source","obj":"craft-sa-dev"},{"subj":"T6372","pred":"source","obj":"craft-sa-dev"},{"subj":"T6373","pred":"source","obj":"craft-sa-dev"},{"subj":"T6374","pred":"source","obj":"craft-sa-dev"},{"subj":"T6375","pred":"source","obj":"craft-sa-dev"},{"subj":"T6376","pred":"source","obj":"craft-sa-dev"},{"subj":"T6377","pred":"source","obj":"craft-sa-dev"},{"subj":"T6378","pred":"source","obj":"craft-sa-dev"},{"subj":"T6379","pred":"source","obj":"craft-sa-dev"},{"subj":"T6380","pred":"source","obj":"craft-sa-dev"},{"subj":"T6381","pred":"source","obj":"craft-sa-dev"},{"subj":"T6382","pred":"source","obj":"craft-sa-dev"},{"subj":"T6383","pred":"source","obj":"craft-sa-dev"},{"subj":"T6384","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T6007","span":{"begin":25,"end":34},"obj":"UBERON:0000922"},{"id":"T6008","span":{"begin":58,"end":68},"obj":"PR_EXT:000008840"},{"id":"T6009","span":{"begin":106,"end":116},"obj":"PR_EXT:000008840"},{"id":"T6010","span":{"begin":129,"end":138},"obj":"CHEBI_EXT:polyatomic_entity_or_group"},{"id":"T6011","span":{"begin":143,"end":151},"obj":"CL_GO_EXT:cell"},{"id":"T6012","span":{"begin":227,"end":236},"obj":"CHEBI_SO_EXT:glutamine"},{"id":"T6013","span":{"begin":247,"end":255},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T6014","span":{"begin":259,"end":269},"obj":"PR_EXT:000008840"},{"id":"T6015","span":{"begin":325,"end":335},"obj":"PR_EXT:000008840"},{"id":"T6016","span":{"begin":354,"end":376},"obj":"UBERON:0005292"},{"id":"T6017","span":{"begin":388,"end":400},"obj":"GO:0007369"},{"id":"T6018","span":{"begin":458,"end":462},"obj":"SO_EXT:0000704"},{"id":"T6019","span":{"begin":458,"end":473},"obj":"GO:0010467"},{"id":"T6020","span":{"begin":477,"end":480},"obj":"PR_EXT:000008840"},{"id":"T6021","span":{"begin":486,"end":489},"obj":"PR_EXT:000008840"},{"id":"T6022","span":{"begin":495,"end":502},"obj":"UBERON:0000922"},{"id":"T6023","span":{"begin":537,"end":547},"obj":"PR_EXT:000008840"},{"id":"T6024","span":{"begin":580,"end":586},"obj":"UBERON:0004341"},{"id":"T6025","span":{"begin":580,"end":596},"obj":"GO:0090009"},{"id":"T6026","span":{"begin":616,"end":647},"obj":"GO:0048339"},{"id":"T6027","span":{"begin":630,"end":647},"obj":"UBERON:0003077"},{"id":"T6028","span":{"begin":689,"end":699},"obj":"PR_EXT:000008840"},{"id":"T6029","span":{"begin":759,"end":768},"obj":"GO:0010467"},{"id":"T6030","span":{"begin":769,"end":774},"obj":"SO_EXT:0000704"}],"attributes":[{"subj":"T6007","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6008","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6009","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6010","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6011","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6012","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6013","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6014","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6015","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6016","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6017","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6018","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6019","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6020","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6021","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6022","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6023","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6024","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6025","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6026","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6027","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6028","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6029","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T6030","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T5795","span":{"begin":25,"end":34},"obj":"UBERON:0000922"},{"id":"T5796","span":{"begin":58,"end":68},"obj":"PR:000008840"},{"id":"T5797","span":{"begin":106,"end":116},"obj":"PR:000008840"},{"id":"T5798","span":{"begin":259,"end":269},"obj":"PR:000008840"},{"id":"T5799","span":{"begin":325,"end":335},"obj":"PR:000008840"},{"id":"T5800","span":{"begin":354,"end":376},"obj":"UBERON:0005292"},{"id":"T5801","span":{"begin":388,"end":400},"obj":"GO:0007369"},{"id":"T5802","span":{"begin":458,"end":462},"obj":"SO:0000704"},{"id":"T5803","span":{"begin":458,"end":473},"obj":"GO:0010467"},{"id":"T5804","span":{"begin":477,"end":480},"obj":"PR:000008840"},{"id":"T5805","span":{"begin":486,"end":489},"obj":"PR:000008840"},{"id":"T5806","span":{"begin":495,"end":502},"obj":"UBERON:0000922"},{"id":"T5807","span":{"begin":537,"end":547},"obj":"PR:000008840"},{"id":"T5808","span":{"begin":580,"end":586},"obj":"UBERON:0004341"},{"id":"T5809","span":{"begin":580,"end":596},"obj":"GO:0090009"},{"id":"T5810","span":{"begin":616,"end":647},"obj":"GO:0048339"},{"id":"T5811","span":{"begin":630,"end":647},"obj":"UBERON:0003077"},{"id":"T5812","span":{"begin":689,"end":699},"obj":"PR:000008840"},{"id":"T5813","span":{"begin":759,"end":768},"obj":"GO:0010467"},{"id":"T5814","span":{"begin":769,"end":774},"obj":"SO:0000704"}],"attributes":[{"subj":"T5795","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5796","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5797","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5798","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5799","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5800","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5801","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5802","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5803","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5804","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5805","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5806","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5807","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5808","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5809","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5810","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5811","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5812","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5813","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5814","pred":"source","obj":"craft-ca-core-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#93a4ec","default":true},{"id":"craft-ca-core-ex-dev","color":"#beec93"},{"id":"craft-ca-core-dev","color":"#ec93d8"}]}]}}