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PMC:1208873 / 2123-6184 JSONTXT

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Id Subject Object Predicate Lexical cue
T927 11-21 NNP denotes Huntington
T928 24-31 NN denotes disease
T929 21-23 POS denotes 's
T930 37-39 VBZ denotes is
T931 32-33 -LRB- denotes (
T932 33-35 NN denotes HD
T933 35-36 -RRB- denotes )
T934 40-41 DT denotes a
T935 81-89 NN denotes disorder
T936 42-52 RB denotes dominantly
T937 53-62 VBN denotes inherited
T938 63-80 JJ denotes neurodegenerative
T939 90-94 WDT denotes that
T940 98-104 VBN denotes caused
T941 95-97 VBZ denotes is
T942 105-107 IN denotes by
T943 108-111 NN denotes CAG
T944 112-119 NNS denotes repeats
T945 120-122 IN denotes in
T946 123-126 DT denotes the
T947 130-135 NN denotes locus
T948 127-129 NN denotes HD
T949 136-140 WDT denotes that
T950 141-147 VBP denotes extend
T951 148-149 DT denotes a
T952 164-169 NN denotes tract
T953 150-163 NN denotes polyglutamine
T954 170-172 IN denotes in
T955 173-174 DT denotes a
T956 198-205 NN denotes protein
T957 175-185 JJ denotes ubiquitous
T958 186-190 NN denotes HEAT
T959 191-197 NN denotes domain
T960 206-212 VBN denotes called
T961 213-223 NN denotes huntingtin
T962 224-225 -LRB- denotes [
T963 225-226 CD denotes 1
T964 226-227 -RRB- denotes ]
T965 227-228 . denotes .
T966 228-408 sentence denotes The molecular mechanism by which the new property that is conferred on huntingtin by the polyglutamine expansion leads to the hallmark loss of striatal neurons in HD is not known.
T967 229-232 DT denotes The
T968 243-252 NN denotes mechanism
T969 233-242 JJ denotes molecular
T970 402-407 VBN denotes known
T971 253-255 IN denotes by
T972 342-347 VBZ denotes leads
T973 256-261 WDT denotes which
T974 262-265 DT denotes the
T975 270-278 NN denotes property
T976 266-269 JJ denotes new
T977 279-283 WDT denotes that
T978 287-296 VBN denotes conferred
T979 284-286 VBZ denotes is
T980 297-299 IN denotes on
T981 300-310 NN denotes huntingtin
T982 311-313 IN denotes by
T983 314-317 DT denotes the
T984 332-341 NN denotes expansion
T985 318-331 NN denotes polyglutamine
T986 348-350 IN denotes to
T987 351-354 DT denotes the
T988 364-368 NN denotes loss
T989 355-363 NN denotes hallmark
T990 369-371 IN denotes of
T991 372-380 JJ denotes striatal
T992 381-388 NNS denotes neurons
T993 389-391 IN denotes in
T994 392-394 NN denotes HD
T995 395-397 VBZ denotes is
T996 398-401 RB denotes not
T997 407-408 . denotes .
T998 408-571 sentence denotes However, polyglutamine expansions in unrelated proteins that target distinct neuronal cell populations cause distinct 'polyglutamine' neurodegenerative disorders.
T999 409-416 RB denotes However
T1000 512-517 VBP denotes cause
T1001 416-418 , denotes ,
T1002 418-431 NN denotes polyglutamine
T1003 432-442 NNS denotes expansions
T1004 443-445 IN denotes in
T1005 446-455 JJ denotes unrelated
T1006 456-464 NN denotes proteins
T1007 465-469 WDT denotes that
T1008 470-476 VBP denotes target
T1009 477-485 JJ denotes distinct
T1010 500-511 NNS denotes populations
T1011 486-494 JJ denotes neuronal
T1012 495-499 NN denotes cell
T1013 518-526 JJ denotes distinct
T1014 561-570 NNS denotes disorders
T1015 527-528 NN denotes '
T1016 528-541 NN denotes polyglutamine
T1017 541-542 '' denotes '
T1018 543-560 JJ denotes neurodegenerative
T1019 570-571 . denotes .
T1020 571-802 sentence denotes This observation strongly suggests that the striatal cell specificity of the polyglutamine expansion in the context of huntingtin must be determined by some aspect of huntingtin's structure, subcellular location or activities [2].
T1021 572-576 DT denotes This
T1022 577-588 NN denotes observation
T1023 598-606 VBZ denotes suggests
T1024 589-597 RB denotes strongly
T1025 607-611 IN denotes that
T1026 710-720 VBN denotes determined
T1027 612-615 DT denotes the
T1028 630-641 NN denotes specificity
T1029 616-624 JJ denotes striatal
T1030 625-629 NN denotes cell
T1031 642-644 IN denotes of
T1032 645-648 DT denotes the
T1033 663-672 NN denotes expansion
T1034 649-662 NN denotes polyglutamine
T1035 673-675 IN denotes in
T1036 676-679 DT denotes the
T1037 680-687 NN denotes context
T1038 688-690 IN denotes of
T1039 691-701 NN denotes huntingtin
T1040 702-706 MD denotes must
T1041 707-709 VB denotes be
T1042 721-723 IN denotes by
T1043 724-728 DT denotes some
T1044 729-735 NN denotes aspect
T1045 736-738 IN denotes of
T1046 739-749 NN denotes huntingtin
T1047 752-761 NN denotes structure
T1048 749-751 POS denotes 's
T1049 761-763 , denotes ,
T1050 763-774 JJ denotes subcellular
T1051 775-783 NN denotes location
T1052 784-786 CC denotes or
T1053 787-797 NNS denotes activities
T1054 798-799 -LRB- denotes [
T1055 799-800 CD denotes 2
T1056 800-801 -RRB- denotes ]
T1057 801-802 . denotes .
T1058 802-988 sentence denotes Huntingtin is postulated to function as a flexible ~350 kDa HEAT domain scaffold that may facilitate the assembly and possibly the subcellular location of large protein complexes [3-7].
T1059 803-813 NN denotes Huntingtin
T1060 817-827 VBN denotes postulated
T1061 814-816 VBZ denotes is
T1062 828-830 TO denotes to
T1063 831-839 VB denotes function
T1064 840-842 IN denotes as
T1065 843-844 DT denotes a
T1066 875-883 NN denotes scaffold
T1067 845-853 JJ denotes flexible
T1068 854-855 SYM denotes ~
T1069 855-858 CD denotes 350
T1070 859-862 NN denotes kDa
T1071 863-867 NN denotes HEAT
T1072 868-874 NN denotes domain
T1073 884-888 WDT denotes that
T1074 893-903 VB denotes facilitate
T1075 889-892 MD denotes may
T1076 904-907 DT denotes the
T1077 908-916 NN denotes assembly
T1078 917-920 CC denotes and
T1079 921-929 RB denotes possibly
T1080 946-954 NN denotes location
T1081 930-933 DT denotes the
T1082 934-945 JJ denotes subcellular
T1083 955-957 IN denotes of
T1084 958-963 JJ denotes large
T1085 972-981 NNS denotes complexes
T1086 964-971 NN denotes protein
T1087 982-983 -LRB- denotes [
T1088 983-984 CD denotes 3
T1089 984-985 SYM denotes -
T1090 985-986 CD denotes 7
T1091 986-987 -RRB- denotes ]
T1092 987-988 . denotes .
T1093 988-1257 sentence denotes Huntingtin's large number of diverse cytoplasmic and nuclear protein binding partners strongly suggest that huntingtin may participate in a variety of cellular processes that range from trafficking of growth factor complexes to gene transcription (reviewed in [5,8,9].
T1094 989-999 NNP denotes Huntingtin
T1095 1008-1014 NN denotes number
T1096 999-1001 POS denotes 's
T1097 1002-1007 JJ denotes large
T1098 1084-1091 VBP denotes suggest
T1099 1015-1017 IN denotes of
T1100 1018-1025 JJ denotes diverse
T1101 1066-1074 NNS denotes partners
T1102 1026-1037 JJ denotes cytoplasmic
T1103 1038-1041 CC denotes and
T1104 1042-1049 JJ denotes nuclear
T1105 1050-1057 NN denotes protein
T1106 1058-1065 NN denotes binding
T1107 1075-1083 RB denotes strongly
T1108 1092-1096 IN denotes that
T1109 1112-1123 VB denotes participate
T1110 1097-1107 NN denotes huntingtin
T1111 1108-1111 MD denotes may
T1112 1124-1126 IN denotes in
T1113 1127-1128 DT denotes a
T1114 1129-1136 NN denotes variety
T1115 1137-1139 IN denotes of
T1116 1140-1148 JJ denotes cellular
T1117 1149-1158 NNS denotes processes
T1118 1159-1163 WDT denotes that
T1119 1164-1169 VBP denotes range
T1120 1170-1174 IN denotes from
T1121 1175-1186 NN denotes trafficking
T1122 1187-1189 IN denotes of
T1123 1190-1196 NN denotes growth
T1124 1204-1213 NNS denotes complexes
T1125 1197-1203 NN denotes factor
T1126 1214-1216 IN denotes to
T1127 1217-1221 NN denotes gene
T1128 1222-1235 NN denotes transcription
T1129 1236-1237 -LRB- denotes (
T1130 1237-1245 VBN denotes reviewed
T1131 1246-1248 IN denotes in
T1132 1249-1250 -LRB- denotes [
T1133 1250-1251 CD denotes 5
T1134 1254-1255 CD denotes 9
T1135 1251-1252 , denotes ,
T1136 1252-1253 CD denotes 8
T1137 1253-1254 , denotes ,
T1138 1255-1256 -RRB- denotes ]
T1139 1256-1257 . denotes .
T1140 1257-1494 sentence denotes However, despite the potential importance of huntingtin's normal function to our understanding of how the dominant polyglutamine mutation causes HD pathology, huntingtin's precise molecular and cellular activities have not been defined.
T1141 1258-1265 RB denotes However
T1142 1486-1493 VBN denotes defined
T1143 1265-1267 , denotes ,
T1144 1267-1274 IN denotes despite
T1145 1275-1278 DT denotes the
T1146 1289-1299 NN denotes importance
T1147 1279-1288 JJ denotes potential
T1148 1300-1302 IN denotes of
T1149 1303-1313 NN denotes huntingtin
T1150 1323-1331 NN denotes function
T1151 1313-1315 POS denotes 's
T1152 1316-1322 JJ denotes normal
T1153 1332-1334 IN denotes to
T1154 1335-1338 PRP$ denotes our
T1155 1339-1352 NN denotes understanding
T1156 1353-1355 IN denotes of
T1157 1356-1359 WRB denotes how
T1158 1396-1402 VBZ denotes causes
T1159 1360-1363 DT denotes the
T1160 1387-1395 NN denotes mutation
T1161 1364-1372 JJ denotes dominant
T1162 1373-1386 NN denotes polyglutamine
T1163 1403-1405 NN denotes HD
T1164 1406-1415 NN denotes pathology
T1165 1415-1417 , denotes ,
T1166 1417-1427 NN denotes huntingtin
T1167 1461-1471 NNS denotes activities
T1168 1427-1429 POS denotes 's
T1169 1430-1437 JJ denotes precise
T1170 1438-1447 JJ denotes molecular
T1171 1448-1451 CC denotes and
T1172 1452-1460 JJ denotes cellular
T1173 1472-1476 VBP denotes have
T1174 1477-1480 RB denotes not
T1175 1481-1485 VBN denotes been
T1176 1493-1494 . denotes .
T1177 1494-1638 sentence denotes Therefore, we, and others, set out to discover huntingtin's essential activities by studying the effects of huntingtin deficiency in the mouse.
T1178 1495-1504 RB denotes Therefore
T1179 1522-1525 VBN denotes set
T1180 1504-1506 , denotes ,
T1181 1506-1508 PRP denotes we
T1182 1508-1510 , denotes ,
T1183 1510-1513 CC denotes and
T1184 1514-1520 NNS denotes others
T1185 1520-1522 , denotes ,
T1186 1526-1529 RP denotes out
T1187 1530-1532 TO denotes to
T1188 1533-1541 VB denotes discover
T1189 1542-1552 NN denotes huntingtin
T1190 1565-1575 NNS denotes activities
T1191 1552-1554 POS denotes 's
T1192 1555-1564 JJ denotes essential
T1193 1576-1578 IN denotes by
T1194 1579-1587 VBG denotes studying
T1195 1588-1591 DT denotes the
T1196 1592-1599 NNS denotes effects
T1197 1600-1602 IN denotes of
T1198 1603-1613 NN denotes huntingtin
T1199 1614-1624 NN denotes deficiency
T1200 1625-1627 IN denotes in
T1201 1628-1631 DT denotes the
T1202 1632-1637 NN denotes mouse
T1203 1637-1638 . denotes .
T1204 1638-1841 sentence denotes Inactivation of the mouse HD gene (Hdh) has shown that huntingtin is not required for cell viability, as evidenced by the survival of mouse embryonic stem cells and neurons that lack huntingtin [10-12].
T1205 1639-1651 NN denotes Inactivation
T1206 1683-1688 VBN denotes shown
T1207 1652-1654 IN denotes of
T1208 1655-1658 DT denotes the
T1209 1668-1672 NN denotes gene
T1210 1659-1664 NN denotes mouse
T1211 1665-1667 NN denotes HD
T1212 1673-1674 -LRB- denotes (
T1213 1674-1677 NN denotes Hdh
T1214 1677-1678 -RRB- denotes )
T1215 1679-1682 VBZ denotes has
T1216 1689-1693 IN denotes that
T1217 1712-1720 VBN denotes required
T1218 1694-1704 NN denotes huntingtin
T1219 1705-1707 VBZ denotes is
T1220 1708-1711 RB denotes not
T1221 1721-1724 IN denotes for
T1222 1725-1729 NN denotes cell
T1223 1730-1739 NN denotes viability
T1224 1739-1741 , denotes ,
T1225 1741-1743 IN denotes as
T1226 1744-1753 VBN denotes evidenced
T1227 1754-1756 IN denotes by
T1228 1757-1760 DT denotes the
T1229 1761-1769 NN denotes survival
T1230 1770-1772 IN denotes of
T1231 1773-1778 NN denotes mouse
T1232 1794-1799 NNS denotes cells
T1233 1779-1788 JJ denotes embryonic
T1234 1789-1793 NN denotes stem
T1235 1800-1803 CC denotes and
T1236 1804-1811 NNS denotes neurons
T1237 1812-1816 WDT denotes that
T1238 1817-1821 VBP denotes lack
T1239 1822-1832 NN denotes huntingtin
T1240 1833-1834 -LRB- denotes [
T1241 1834-1836 CD denotes 10
T1242 1836-1837 SYM denotes -
T1243 1837-1839 CD denotes 12
T1244 1839-1840 -RRB- denotes ]
T1245 1840-1841 . denotes .
T1246 1841-1955 sentence denotes However, huntingtin is needed at the level of the organism for proper mammalian embryonic development [10,13,14].
T1247 1842-1849 RB denotes However
T1248 1865-1871 VBN denotes needed
T1249 1849-1851 , denotes ,
T1250 1851-1861 NN denotes huntingtin
T1251 1862-1864 VBZ denotes is
T1252 1872-1874 IN denotes at
T1253 1875-1878 DT denotes the
T1254 1879-1884 NN denotes level
T1255 1885-1887 IN denotes of
T1256 1888-1891 DT denotes the
T1257 1892-1900 NN denotes organism
T1258 1901-1904 IN denotes for
T1259 1905-1911 JJ denotes proper
T1260 1932-1943 NN denotes development
T1261 1912-1921 JJ denotes mammalian
T1262 1922-1931 JJ denotes embryonic
T1263 1944-1945 -LRB- denotes [
T1264 1951-1953 CD denotes 14
T1265 1945-1947 CD denotes 10
T1266 1947-1948 , denotes ,
T1267 1948-1950 CD denotes 13
T1268 1950-1951 , denotes ,
T1269 1953-1954 -RRB- denotes ]
T1270 1954-1955 . denotes .
T1271 1955-2143 sentence denotes Complete lack of huntingtin results in developmental arrest during gastrulation, while severe reduction of huntingtin levels results in abnormal neurogenesis and perinatal lethality [15].
T1272 1956-1964 JJ denotes Complete
T1273 1965-1969 NN denotes lack
T1274 1984-1991 VBZ denotes results
T1275 1970-1972 IN denotes of
T1276 1973-1983 NN denotes huntingtin
T1277 1992-1994 IN denotes in
T1278 1995-2008 JJ denotes developmental
T1279 2009-2015 NN denotes arrest
T1280 2016-2022 IN denotes during
T1281 2023-2035 NN denotes gastrulation
T1282 2035-2037 , denotes ,
T1283 2037-2042 IN denotes while
T1284 2081-2088 VBZ denotes results
T1285 2043-2049 JJ denotes severe
T1286 2050-2059 NN denotes reduction
T1287 2060-2062 IN denotes of
T1288 2063-2073 NN denotes huntingtin
T1289 2074-2080 NNS denotes levels
T1290 2089-2091 IN denotes in
T1291 2092-2100 JJ denotes abnormal
T1292 2101-2113 NN denotes neurogenesis
T1293 2114-2117 CC denotes and
T1294 2118-2127 JJ denotes perinatal
T1295 2128-2137 NN denotes lethality
T1296 2138-2139 -LRB- denotes [
T1297 2139-2141 CD denotes 15
T1298 2141-2142 -RRB- denotes ]
T1299 2142-2143 . denotes .
T1300 2143-2308 sentence denotes Analysis of huntingtin deficient Hdhex4/5/Hdhex4/5 embryos reveals that homozygous inactivation of the mouse HD gene does not overtly affect development until E7.0.
T1301 2144-2152 NN denotes Analysis
T1302 2203-2210 VBZ denotes reveals
T1303 2153-2155 IN denotes of
T1304 2156-2166 NN denotes huntingtin
T1305 2167-2176 JJ denotes deficient
T1306 2195-2202 NNS denotes embryos
T1307 2177-2183 NN denotes Hdhex4
T1308 2183-2184 HYPH denotes /
T1309 2184-2185 CD denotes 5
T1310 2185-2186 HYPH denotes /
T1311 2186-2192 NN denotes Hdhex4
T1312 2192-2193 HYPH denotes /
T1313 2193-2194 CD denotes 5
T1314 2211-2215 IN denotes that
T1315 2278-2284 VB denotes affect
T1316 2216-2226 JJ denotes homozygous
T1317 2227-2239 NN denotes inactivation
T1318 2240-2242 IN denotes of
T1319 2243-2246 DT denotes the
T1320 2256-2260 NN denotes gene
T1321 2247-2252 NN denotes mouse
T1322 2253-2255 NN denotes HD
T1323 2261-2265 VBZ denotes does
T1324 2266-2269 RB denotes not
T1325 2270-2277 RB denotes overtly
T1326 2285-2296 NN denotes development
T1327 2297-2302 IN denotes until
T1328 2303-2307 NN denotes E7.0
T1329 2307-2308 . denotes .
T1330 2308-2431 sentence denotes By E7.5, mutant embryos exhibit a shortened primitive streak, reduced size and, by morphology, lack a node and head folds.
T1331 2309-2311 IN denotes By
T1332 2333-2340 VBP denotes exhibit
T1333 2312-2316 NN denotes E7.5
T1334 2316-2318 , denotes ,
T1335 2318-2324 NN denotes mutant
T1336 2325-2332 NNS denotes embryos
T1337 2341-2342 DT denotes a
T1338 2363-2369 NN denotes streak
T1339 2343-2352 VBN denotes shortened
T1340 2353-2362 JJ denotes primitive
T1341 2369-2371 , denotes ,
T1342 2371-2378 VBN denotes reduced
T1343 2379-2383 NN denotes size
T1344 2384-2387 CC denotes and
T1345 2387-2389 , denotes ,
T1346 2389-2391 IN denotes by
T1347 2404-2408 VBP denotes lack
T1348 2392-2402 NN denotes morphology
T1349 2402-2404 , denotes ,
T1350 2409-2410 DT denotes a
T1351 2411-2415 NN denotes node
T1352 2416-2419 CC denotes and
T1353 2420-2424 NN denotes head
T1354 2425-2430 NNS denotes folds
T1355 2430-2431 . denotes .
T1356 2431-2474 sentence denotes Mutants are rapidly resorbed by E8.0 [10].
T1357 2432-2439 NNS denotes Mutants
T1358 2452-2460 VBN denotes resorbed
T1359 2440-2443 VBP denotes are
T1360 2444-2451 RB denotes rapidly
T1361 2461-2463 IN denotes by
T1362 2464-2468 NN denotes E8.0
T1363 2469-2470 -LRB- denotes [
T1364 2470-2472 CD denotes 10
T1365 2472-2473 -RRB- denotes ]
T1366 2473-2474 . denotes .
T1367 2474-2740 sentence denotes Importantly, the expression of huntingtin only in extraembryonic tissues in chimeras rescues this gastrulation phenotype, suggesting that huntingtin is required only in cells of the extraembryonic lineage and acts in a cell non-autonomous manner at this stage [16].
T1368 2475-2486 RB denotes Importantly
T1369 2560-2567 VBZ denotes rescues
T1370 2486-2488 , denotes ,
T1371 2488-2491 DT denotes the
T1372 2492-2502 NN denotes expression
T1373 2503-2505 IN denotes of
T1374 2506-2516 NN denotes huntingtin
T1375 2517-2521 RB denotes only
T1376 2522-2524 IN denotes in
T1377 2525-2539 JJ denotes extraembryonic
T1378 2540-2547 NNS denotes tissues
T1379 2548-2550 IN denotes in
T1380 2551-2559 NNS denotes chimeras
T1381 2568-2572 DT denotes this
T1382 2586-2595 NN denotes phenotype
T1383 2573-2585 NN denotes gastrulation
T1384 2595-2597 , denotes ,
T1385 2597-2607 VBG denotes suggesting
T1386 2608-2612 IN denotes that
T1387 2627-2635 VBN denotes required
T1388 2613-2623 NN denotes huntingtin
T1389 2624-2626 VBZ denotes is
T1390 2636-2640 RB denotes only
T1391 2641-2643 IN denotes in
T1392 2644-2649 NNS denotes cells
T1393 2650-2652 IN denotes of
T1394 2653-2656 DT denotes the
T1395 2672-2679 NN denotes lineage
T1396 2657-2671 JJ denotes extraembryonic
T1397 2680-2683 CC denotes and
T1398 2684-2688 VBZ denotes acts
T1399 2689-2691 IN denotes in
T1400 2692-2693 DT denotes a
T1401 2714-2720 NN denotes manner
T1402 2694-2698 NN denotes cell
T1403 2699-2713 JJ denotes non-autonomous
T1404 2721-2723 IN denotes at
T1405 2724-2728 DT denotes this
T1406 2729-2734 NN denotes stage
T1407 2735-2736 -LRB- denotes [
T1408 2736-2738 CD denotes 16
T1409 2738-2739 -RRB- denotes ]
T1410 2739-2740 . denotes .
T1411 2740-2980 sentence denotes Extraembryonic tissues are essential for supplying nutrients and signals that direct anterior/posterior axis formation and patterning in the developing embryo (reviewed in [17]), implicating huntingtin in either or both of these processes.
T1412 2741-2755 JJ denotes Extraembryonic
T1413 2756-2763 NNS denotes tissues
T1414 2764-2767 VBP denotes are
T1415 2768-2777 JJ denotes essential
T1416 2778-2781 IN denotes for
T1417 2782-2791 VBG denotes supplying
T1418 2792-2801 NNS denotes nutrients
T1419 2802-2805 CC denotes and
T1420 2806-2813 NNS denotes signals
T1421 2814-2818 WDT denotes that
T1422 2819-2825 VBP denotes direct
T1423 2826-2834 JJ denotes anterior
T1424 2835-2844 JJ denotes posterior
T1425 2834-2835 HYPH denotes /
T1426 2850-2859 NN denotes formation
T1427 2845-2849 NN denotes axis
T1428 2860-2863 CC denotes and
T1429 2864-2874 NN denotes patterning
T1430 2875-2877 IN denotes in
T1431 2878-2881 DT denotes the
T1432 2893-2899 NN denotes embryo
T1433 2882-2892 VBG denotes developing
T1434 2900-2901 -LRB- denotes (
T1435 2901-2909 VBN denotes reviewed
T1436 2910-2912 IN denotes in
T1437 2913-2914 -LRB- denotes [
T1438 2914-2916 CD denotes 17
T1439 2916-2917 -RRB- denotes ]
T1440 2917-2918 -RRB- denotes )
T1441 2918-2920 , denotes ,
T1442 2920-2931 VBG denotes implicating
T1443 2932-2942 NN denotes huntingtin
T1444 2943-2945 IN denotes in
T1445 2946-2952 DT denotes either
T1446 2953-2955 CC denotes or
T1447 2956-2960 DT denotes both
T1448 2961-2963 IN denotes of
T1449 2964-2969 DT denotes these
T1450 2970-2979 NNS denotes processes
T1451 2979-2980 . denotes .
T1452 2980-3063 sentence denotes Of these possibilities, the nutritive role has been more extensively investigated.
T1453 2981-2983 IN denotes Of
T1454 3050-3062 VBN denotes investigated
T1455 2984-2989 DT denotes these
T1456 2990-3003 NNS denotes possibilities
T1457 3003-3005 , denotes ,
T1458 3005-3008 DT denotes the
T1459 3019-3023 NN denotes role
T1460 3009-3018 JJ denotes nutritive
T1461 3024-3027 VBZ denotes has
T1462 3028-3032 VBN denotes been
T1463 3033-3037 RBR denotes more
T1464 3038-3049 RB denotes extensively
T1465 3062-3063 . denotes .
T1466 3063-3370 sentence denotes However, huntingtin deficient embryos do not display obvious visceral endoderm defects, with the notable exception of compromised iron transport in later stage mutants, although iron uptake is undisturbed [16] and endocytosis is not impaired in huntingtin deficient embryos or embryonic stem cells [16,18].
T1467 3064-3071 RB denotes However
T1468 3109-3116 VB denotes display
T1469 3071-3073 , denotes ,
T1470 3073-3083 NN denotes huntingtin
T1471 3084-3093 JJ denotes deficient
T1472 3094-3101 NNS denotes embryos
T1473 3102-3104 VBP denotes do
T1474 3105-3108 RB denotes not
T1475 3117-3124 JJ denotes obvious
T1476 3143-3150 NNS denotes defects
T1477 3125-3133 JJ denotes visceral
T1478 3134-3142 NN denotes endoderm
T1479 3150-3152 , denotes ,
T1480 3152-3156 IN denotes with
T1481 3157-3160 DT denotes the
T1482 3169-3178 NN denotes exception
T1483 3161-3168 JJ denotes notable
T1484 3179-3181 IN denotes of
T1485 3182-3193 VBN denotes compromised
T1486 3199-3208 NN denotes transport
T1487 3194-3198 NN denotes iron
T1488 3209-3211 IN denotes in
T1489 3212-3217 JJ denotes later
T1490 3224-3231 NNS denotes mutants
T1491 3218-3223 NN denotes stage
T1492 3231-3233 , denotes ,
T1493 3233-3241 IN denotes although
T1494 3254-3256 VBZ denotes is
T1495 3242-3246 NN denotes iron
T1496 3247-3253 NN denotes uptake
T1497 3257-3268 JJ denotes undisturbed
T1498 3269-3270 -LRB- denotes [
T1499 3270-3272 CD denotes 16
T1500 3272-3273 -RRB- denotes ]
T1501 3274-3277 CC denotes and
T1502 3278-3289 NN denotes endocytosis
T1503 3297-3305 VBN denotes impaired
T1504 3290-3292 VBZ denotes is
T1505 3293-3296 RB denotes not
T1506 3306-3308 IN denotes in
T1507 3309-3319 NN denotes huntingtin
T1508 3320-3329 JJ denotes deficient
T1509 3330-3337 NNS denotes embryos
T1510 3338-3340 CC denotes or
T1511 3341-3350 JJ denotes embryonic
T1512 3356-3361 NNS denotes cells
T1513 3351-3355 NN denotes stem
T1514 3362-3363 -LRB- denotes [
T1515 3366-3368 CD denotes 18
T1516 3363-3365 CD denotes 16
T1517 3365-3366 , denotes ,
T1518 3368-3369 -RRB- denotes ]
T1519 3369-3370 . denotes .
T1520 3370-3646 sentence denotes By the same token, huntingtin shuttles through the nucleus, where it is required for proper nuclear localization of its transcription factor partners, suggesting that huntingtin may play a role in transcription cascades in extraembryonic tissues that pattern the embryo [18].
T1521 3371-3373 IN denotes By
T1522 3401-3409 VBZ denotes shuttles
T1523 3374-3377 DT denotes the
T1524 3383-3388 NN denotes token
T1525 3378-3382 JJ denotes same
T1526 3388-3390 , denotes ,
T1527 3390-3400 NN denotes huntingtin
T1528 3410-3417 IN denotes through
T1529 3418-3421 DT denotes the
T1530 3422-3429 NN denotes nucleus
T1531 3429-3431 , denotes ,
T1532 3431-3436 WRB denotes where
T1533 3443-3451 VBN denotes required
T1534 3437-3439 PRP denotes it
T1535 3440-3442 VBZ denotes is
T1536 3452-3455 IN denotes for
T1537 3456-3462 JJ denotes proper
T1538 3471-3483 NN denotes localization
T1539 3463-3470 JJ denotes nuclear
T1540 3484-3486 IN denotes of
T1541 3487-3490 PRP$ denotes its
T1542 3512-3520 NNS denotes partners
T1543 3491-3504 NN denotes transcription
T1544 3505-3511 NN denotes factor
T1545 3520-3522 , denotes ,
T1546 3522-3532 VBG denotes suggesting
T1547 3533-3537 IN denotes that
T1548 3553-3557 VB denotes play
T1549 3538-3548 NN denotes huntingtin
T1550 3549-3552 MD denotes may
T1551 3558-3559 DT denotes a
T1552 3560-3564 NN denotes role
T1553 3565-3567 IN denotes in
T1554 3568-3581 NN denotes transcription
T1555 3582-3590 NNS denotes cascades
T1556 3591-3593 IN denotes in
T1557 3594-3608 JJ denotes extraembryonic
T1558 3609-3616 NNS denotes tissues
T1559 3617-3621 WDT denotes that
T1560 3622-3629 VBP denotes pattern
T1561 3630-3633 DT denotes the
T1562 3634-3640 NN denotes embryo
T1563 3641-3642 -LRB- denotes [
T1564 3642-3644 CD denotes 18
T1565 3644-3645 -RRB- denotes ]
T1566 3645-3646 . denotes .
T1567 3646-3841 sentence denotes Therefore, we have examined this hypothesis, by monitoring the expression of genes that determine normal embryonic patterning and morphogenesis in Hdhex4/5/Hdhex4/5 huntingtin deficient embryos.
T1568 3647-3656 RB denotes Therefore
T1569 3666-3674 VBN denotes examined
T1570 3656-3658 , denotes ,
T1571 3658-3660 PRP denotes we
T1572 3661-3665 VBP denotes have
T1573 3675-3679 DT denotes this
T1574 3680-3690 NN denotes hypothesis
T1575 3690-3692 , denotes ,
T1576 3692-3694 IN denotes by
T1577 3695-3705 VBG denotes monitoring
T1578 3706-3709 DT denotes the
T1579 3710-3720 NN denotes expression
T1580 3721-3723 IN denotes of
T1581 3724-3729 NNS denotes genes
T1582 3730-3734 WDT denotes that
T1583 3735-3744 VBP denotes determine
T1584 3745-3751 JJ denotes normal
T1585 3762-3772 NN denotes patterning
T1586 3752-3761 JJ denotes embryonic
T1587 3773-3776 CC denotes and
T1588 3777-3790 NN denotes morphogenesis
T1589 3791-3793 IN denotes in
T1590 3794-3800 NN denotes Hdhex4
T1591 3833-3840 NNS denotes embryos
T1592 3800-3801 HYPH denotes /
T1593 3801-3802 CD denotes 5
T1594 3802-3803 HYPH denotes /
T1595 3803-3809 NN denotes Hdhex4
T1596 3809-3810 HYPH denotes /
T1597 3810-3811 CD denotes 5
T1598 3812-3822 NN denotes huntingtin
T1599 3823-3832 JJ denotes deficient
T1600 3840-3841 . denotes .
T1601 3841-4061 sentence denotes Our results support and refine the hypothesis, indicating that huntingtin is required for proper mesoderm patterning and for normal regional restriction of the expression of a subset of growth and transcription factors.
T1602 3842-3845 PRP$ denotes Our
T1603 3846-3853 NNS denotes results
T1604 3854-3861 VBP denotes support
T1605 3862-3865 CC denotes and
T1606 3866-3872 VBP denotes refine
T1607 3873-3876 DT denotes the
T1608 3877-3887 NN denotes hypothesis
T1609 3887-3889 , denotes ,
T1610 3889-3899 VBG denotes indicating
T1611 3900-3904 IN denotes that
T1612 3919-3927 VBN denotes required
T1613 3905-3915 NN denotes huntingtin
T1614 3916-3918 VBZ denotes is
T1615 3928-3931 IN denotes for
T1616 3932-3938 JJ denotes proper
T1617 3948-3958 NN denotes patterning
T1618 3939-3947 NN denotes mesoderm
T1619 3959-3962 CC denotes and
T1620 3963-3966 IN denotes for
T1621 3967-3973 JJ denotes normal
T1622 3983-3994 NN denotes restriction
T1623 3974-3982 JJ denotes regional
T1624 3995-3997 IN denotes of
T1625 3998-4001 DT denotes the
T1626 4002-4012 NN denotes expression
T1627 4013-4015 IN denotes of
T1628 4016-4017 DT denotes a
T1629 4018-4024 NN denotes subset
T1630 4025-4027 IN denotes of
T1631 4028-4034 NN denotes growth
T1632 4053-4060 NNS denotes factors
T1633 4035-4038 CC denotes and
T1634 4039-4052 NN denotes transcription
T1635 4060-4061 . denotes .
R337 T927 T928 poss Huntington,disease
R338 T928 T930 nsubj disease,is
R339 T929 T927 case 's,Huntington
R340 T931 T928 punct (,disease
R341 T932 T928 appos HD,disease
R342 T933 T930 punct ),is
R343 T934 T935 det a,disorder
R344 T935 T930 attr disorder,is
R345 T936 T937 advmod dominantly,inherited
R346 T937 T935 amod inherited,disorder
R347 T938 T935 amod neurodegenerative,disorder
R348 T939 T940 dep that,caused
R349 T940 T935 relcl caused,disorder
R350 T941 T940 auxpass is,caused
R351 T942 T940 agent by,caused
R352 T943 T944 compound CAG,repeats
R353 T944 T942 pobj repeats,by
R354 T945 T944 prep in,repeats
R355 T946 T947 det the,locus
R356 T947 T945 pobj locus,in
R357 T948 T947 compound HD,locus
R358 T949 T950 dep that,extend
R359 T950 T944 relcl extend,repeats
R360 T951 T952 det a,tract
R361 T952 T950 dobj tract,extend
R362 T953 T952 compound polyglutamine,tract
R363 T954 T950 prep in,extend
R364 T955 T956 det a,protein
R365 T956 T954 pobj protein,in
R366 T957 T956 amod ubiquitous,protein
R367 T958 T959 compound HEAT,domain
R368 T959 T956 compound domain,protein
R369 T960 T956 acl called,protein
R370 T961 T960 oprd huntingtin,called
R371 T962 T963 punct [,1
R372 T963 T950 parataxis 1,extend
R373 T964 T963 punct ],1
R374 T965 T930 punct .,is
R375 T967 T968 det The,mechanism
R376 T968 T970 nsubjpass mechanism,known
R377 T969 T968 amod molecular,mechanism
R378 T971 T972 prep by,leads
R379 T972 T968 relcl leads,mechanism
R380 T973 T971 pobj which,by
R381 T974 T975 det the,property
R382 T975 T972 nsubj property,leads
R383 T976 T975 amod new,property
R384 T977 T978 dep that,conferred
R385 T978 T975 relcl conferred,property
R386 T979 T978 auxpass is,conferred
R387 T980 T978 prep on,conferred
R388 T981 T980 pobj huntingtin,on
R389 T982 T978 agent by,conferred
R390 T983 T984 det the,expansion
R391 T984 T982 pobj expansion,by
R392 T985 T984 compound polyglutamine,expansion
R393 T986 T972 prep to,leads
R394 T987 T988 det the,loss
R395 T988 T986 pobj loss,to
R396 T989 T988 compound hallmark,loss
R397 T990 T988 prep of,loss
R398 T991 T992 amod striatal,neurons
R399 T992 T990 pobj neurons,of
R400 T993 T972 prep in,leads
R401 T994 T993 pobj HD,in
R402 T995 T970 auxpass is,known
R403 T996 T970 neg not,known
R404 T997 T970 punct .,known
R405 T999 T1000 advmod However,cause
R406 T1001 T1000 punct ", ",cause
R407 T1002 T1003 compound polyglutamine,expansions
R408 T1003 T1000 nsubj expansions,cause
R409 T1004 T1003 prep in,expansions
R410 T1005 T1006 amod unrelated,proteins
R411 T1006 T1004 pobj proteins,in
R412 T1007 T1008 dep that,target
R413 T1008 T1006 relcl target,proteins
R414 T1009 T1010 amod distinct,populations
R415 T1010 T1008 dobj populations,target
R416 T1011 T1010 amod neuronal,populations
R417 T1012 T1010 compound cell,populations
R418 T1013 T1014 amod distinct,disorders
R419 T1014 T1000 dobj disorders,cause
R420 T1015 T1014 nmod ',disorders
R421 T1016 T1014 nmod polyglutamine,disorders
R422 T1017 T1014 punct ',disorders
R423 T1018 T1014 amod neurodegenerative,disorders
R424 T1019 T1000 punct .,cause
R425 T1021 T1022 det This,observation
R426 T1022 T1023 nsubj observation,suggests
R427 T1024 T1023 advmod strongly,suggests
R428 T1025 T1026 mark that,determined
R429 T1026 T1023 ccomp determined,suggests
R430 T1027 T1028 det the,specificity
R431 T1028 T1026 nsubjpass specificity,determined
R432 T1029 T1030 amod striatal,cell
R433 T1030 T1028 compound cell,specificity
R434 T1031 T1028 prep of,specificity
R435 T1032 T1033 det the,expansion
R436 T1033 T1031 pobj expansion,of
R437 T1034 T1033 compound polyglutamine,expansion
R438 T1035 T1028 prep in,specificity
R439 T1036 T1037 det the,context
R440 T1037 T1035 pobj context,in
R441 T1038 T1037 prep of,context
R442 T1039 T1038 pobj huntingtin,of
R443 T1040 T1026 aux must,determined
R444 T1041 T1026 auxpass be,determined
R445 T1042 T1026 agent by,determined
R446 T1043 T1044 det some,aspect
R447 T1044 T1042 pobj aspect,by
R448 T1045 T1044 prep of,aspect
R449 T1046 T1047 poss huntingtin,structure
R450 T1047 T1045 pobj structure,of
R451 T1048 T1046 case 's,huntingtin
R452 T1049 T1047 punct ", ",structure
R453 T1050 T1051 amod subcellular,location
R454 T1051 T1047 conj location,structure
R455 T1052 T1051 cc or,location
R456 T1053 T1051 conj activities,location
R457 T1054 T1055 punct [,2
R458 T1055 T1026 parataxis 2,determined
R459 T1056 T1055 punct ],2
R460 T1057 T1023 punct .,suggests
R461 T1059 T1060 nsubjpass Huntingtin,postulated
R462 T1061 T1060 auxpass is,postulated
R463 T1062 T1063 aux to,function
R464 T1063 T1060 xcomp function,postulated
R465 T1064 T1063 prep as,function
R466 T1065 T1066 det a,scaffold
R467 T1066 T1064 pobj scaffold,as
R468 T1067 T1066 amod flexible,scaffold
R469 T1068 T1069 punct ~,350
R470 T1069 T1070 nummod 350,kDa
R471 T1070 T1066 compound kDa,scaffold
R472 T1071 T1072 compound HEAT,domain
R473 T1072 T1066 compound domain,scaffold
R474 T1073 T1074 dep that,facilitate
R475 T1074 T1066 relcl facilitate,scaffold
R476 T1075 T1074 aux may,facilitate
R477 T1076 T1077 det the,assembly
R478 T1077 T1074 dobj assembly,facilitate
R479 T1078 T1077 cc and,assembly
R480 T1079 T1080 advmod possibly,location
R481 T1080 T1077 conj location,assembly
R482 T1081 T1080 det the,location
R483 T1082 T1080 amod subcellular,location
R484 T1083 T1077 prep of,assembly
R485 T1084 T1085 amod large,complexes
R486 T1085 T1083 pobj complexes,of
R487 T1086 T1085 compound protein,complexes
R488 T1087 T1088 punct [,3
R489 T1088 T1060 parataxis 3,postulated
R490 T1089 T1090 punct -,7
R491 T1090 T1088 prep 7,3
R492 T1091 T1088 punct ],3
R493 T1092 T1060 punct .,postulated
R494 T1094 T1095 poss Huntingtin,number
R495 T1095 T1098 nsubj number,suggest
R496 T1096 T1094 case 's,Huntingtin
R497 T1097 T1095 amod large,number
R498 T1099 T1095 prep of,number
R499 T1100 T1101 amod diverse,partners
R500 T1101 T1099 pobj partners,of
R501 T1102 T1101 amod cytoplasmic,partners
R502 T1103 T1102 cc and,cytoplasmic
R503 T1104 T1102 conj nuclear,cytoplasmic
R504 T1105 T1101 compound protein,partners
R505 T1106 T1101 compound binding,partners
R506 T1107 T1098 advmod strongly,suggest
R507 T1108 T1109 mark that,participate
R508 T1109 T1098 ccomp participate,suggest
R509 T1110 T1109 nsubj huntingtin,participate
R510 T1111 T1109 aux may,participate
R511 T1112 T1109 prep in,participate
R512 T1113 T1114 det a,variety
R513 T1114 T1112 pobj variety,in
R514 T1115 T1114 prep of,variety
R515 T1116 T1117 amod cellular,processes
R516 T1117 T1115 pobj processes,of
R517 T1118 T1119 dep that,range
R518 T1119 T1117 relcl range,processes
R519 T1120 T1119 prep from,range
R520 T1121 T1120 pobj trafficking,from
R521 T1122 T1121 prep of,trafficking
R522 T1123 T1124 compound growth,complexes
R523 T1124 T1122 pobj complexes,of
R524 T1125 T1124 compound factor,complexes
R525 T1126 T1120 prep to,from
R526 T1127 T1128 compound gene,transcription
R527 T1128 T1126 pobj transcription,to
R528 T1129 T1130 punct (,reviewed
R529 T1130 T1109 parataxis reviewed,participate
R530 T1131 T1130 prep in,reviewed
R531 T1132 T1131 punct [,in
R532 T1133 T1134 nummod 5,9
R533 T1134 T1131 pobj 9,in
R534 T1135 T1134 punct ",",9
R535 T1136 T1134 nummod 8,9
R536 T1137 T1134 punct ",",9
R537 T1138 T1130 punct ],reviewed
R538 T1139 T1098 punct .,suggest
R539 T1141 T1142 advmod However,defined
R540 T1143 T1142 punct ", ",defined
R541 T1144 T1142 prep despite,defined
R542 T1145 T1146 det the,importance
R543 T1146 T1144 pobj importance,despite
R544 T1147 T1146 amod potential,importance
R545 T1148 T1146 prep of,importance
R546 T1149 T1150 poss huntingtin,function
R547 T1150 T1148 pobj function,of
R548 T1151 T1149 case 's,huntingtin
R549 T1152 T1150 amod normal,function
R550 T1153 T1146 prep to,importance
R551 T1154 T1155 poss our,understanding
R552 T1155 T1153 pobj understanding,to
R553 T1156 T1155 prep of,understanding
R554 T1157 T1158 advmod how,causes
R555 T1158 T1156 pcomp causes,of
R556 T1159 T1160 det the,mutation
R557 T1160 T1158 nsubj mutation,causes
R558 T1161 T1160 amod dominant,mutation
R559 T1162 T1160 compound polyglutamine,mutation
R560 T1163 T1164 compound HD,pathology
R561 T1164 T1158 dobj pathology,causes
R562 T1165 T1142 punct ", ",defined
R563 T1166 T1167 poss huntingtin,activities
R564 T1167 T1142 nsubjpass activities,defined
R565 T1168 T1166 case 's,huntingtin
R566 T1169 T1167 amod precise,activities
R567 T1170 T1167 amod molecular,activities
R568 T1171 T1170 cc and,molecular
R569 T1172 T1170 conj cellular,molecular
R570 T1173 T1142 aux have,defined
R571 T1174 T1142 neg not,defined
R572 T1175 T1142 auxpass been,defined
R573 T1176 T1142 punct .,defined
R574 T1178 T1179 advmod Therefore,set
R575 T1180 T1179 punct ", ",set
R576 T1181 T1179 nsubj we,set
R577 T1182 T1181 punct ", ",we
R578 T1183 T1181 cc and,we
R579 T1184 T1181 conj others,we
R580 T1185 T1179 punct ", ",set
R581 T1186 T1179 prt out,set
R582 T1187 T1188 aux to,discover
R583 T1188 T1179 xcomp discover,set
R584 T1189 T1190 poss huntingtin,activities
R585 T1190 T1188 dobj activities,discover
R586 T1191 T1189 case 's,huntingtin
R587 T1192 T1190 amod essential,activities
R588 T1193 T1188 prep by,discover
R589 T1194 T1193 pcomp studying,by
R590 T1195 T1196 det the,effects
R591 T1196 T1194 dobj effects,studying
R592 T1197 T1196 prep of,effects
R593 T1198 T1199 compound huntingtin,deficiency
R594 T1199 T1197 pobj deficiency,of
R595 T1200 T1194 prep in,studying
R596 T1201 T1202 det the,mouse
R597 T1202 T1200 pobj mouse,in
R598 T1203 T1179 punct .,set
R599 T1205 T1206 nsubj Inactivation,shown
R600 T1207 T1205 prep of,Inactivation
R601 T1208 T1209 det the,gene
R602 T1209 T1207 pobj gene,of
R603 T1210 T1209 compound mouse,gene
R604 T1211 T1209 compound HD,gene
R605 T1212 T1209 punct (,gene
R606 T1213 T1209 appos Hdh,gene
R607 T1214 T1206 punct ),shown
R608 T1215 T1206 aux has,shown
R609 T1216 T1217 mark that,required
R610 T1217 T1206 ccomp required,shown
R611 T1218 T1217 nsubjpass huntingtin,required
R612 T1219 T1217 auxpass is,required
R613 T1220 T1217 neg not,required
R614 T1221 T1217 prep for,required
R615 T1222 T1223 compound cell,viability
R616 T1223 T1221 pobj viability,for
R617 T1224 T1217 punct ", ",required
R618 T1225 T1226 mark as,evidenced
R619 T1226 T1217 advcl evidenced,required
R620 T1227 T1226 agent by,evidenced
R621 T1228 T1229 det the,survival
R622 T1229 T1227 pobj survival,by
R623 T1230 T1229 prep of,survival
R624 T1231 T1232 nmod mouse,cells
R625 T1232 T1230 pobj cells,of
R626 T1233 T1232 amod embryonic,cells
R627 T1234 T1232 compound stem,cells
R628 T1235 T1232 cc and,cells
R629 T1236 T1232 conj neurons,cells
R630 T1237 T1238 dep that,lack
R631 T1238 T1236 relcl lack,neurons
R632 T1239 T1238 dobj huntingtin,lack
R633 T1240 T1241 punct [,10
R634 T1241 T1226 parataxis 10,evidenced
R635 T1242 T1243 punct -,12
R636 T1243 T1241 prep 12,10
R637 T1244 T1241 punct ],10
R638 T1245 T1206 punct .,shown
R639 T1247 T1248 advmod However,needed
R640 T1249 T1248 punct ", ",needed
R641 T1250 T1248 nsubjpass huntingtin,needed
R642 T1251 T1248 auxpass is,needed
R643 T1252 T1248 prep at,needed
R644 T1253 T1254 det the,level
R645 T1254 T1252 pobj level,at
R646 T1255 T1254 prep of,level
R647 T1256 T1257 det the,organism
R648 T1257 T1255 pobj organism,of
R649 T1258 T1248 prep for,needed
R650 T1259 T1260 amod proper,development
R651 T1260 T1258 pobj development,for
R652 T1261 T1260 amod mammalian,development
R653 T1262 T1260 amod embryonic,development
R654 T1263 T1264 punct [,14
R655 T1264 T1248 parataxis 14,needed
R656 T1265 T1264 nummod 10,14
R657 T1266 T1264 punct ",",14
R658 T1267 T1264 nummod 13,14
R659 T1268 T1264 punct ",",14
R660 T1269 T1264 punct ],14
R661 T1270 T1248 punct .,needed
R662 T1272 T1273 amod Complete,lack
R663 T1273 T1274 nsubj lack,results
R664 T1275 T1273 prep of,lack
R665 T1276 T1275 pobj huntingtin,of
R666 T1277 T1274 prep in,results
R667 T1278 T1279 amod developmental,arrest
R668 T1279 T1277 pobj arrest,in
R669 T1280 T1274 prep during,results
R670 T1281 T1280 pobj gastrulation,during
R671 T1282 T1274 punct ", ",results
R672 T1283 T1284 mark while,results
R673 T1284 T1274 advcl results,results
R674 T1285 T1286 amod severe,reduction
R675 T1286 T1284 nsubj reduction,results
R676 T1287 T1286 prep of,reduction
R677 T1288 T1289 compound huntingtin,levels
R678 T1289 T1287 pobj levels,of
R679 T1290 T1284 prep in,results
R680 T1291 T1292 amod abnormal,neurogenesis
R681 T1292 T1290 pobj neurogenesis,in
R682 T1293 T1292 cc and,neurogenesis
R683 T1294 T1295 amod perinatal,lethality
R684 T1295 T1292 conj lethality,neurogenesis
R685 T1296 T1297 punct [,15
R686 T1297 T1284 parataxis 15,results
R687 T1298 T1297 punct ],15
R688 T1299 T1274 punct .,results
R689 T1301 T1302 nsubj Analysis,reveals
R690 T1303 T1301 prep of,Analysis
R691 T1304 T1305 npadvmod huntingtin,deficient
R692 T1305 T1306 amod deficient,embryos
R693 T1306 T1303 pobj embryos,of
R694 T1307 T1306 nmod Hdhex4,embryos
R695 T1308 T1307 punct /,Hdhex4
R696 T1309 T1307 nummod 5,Hdhex4
R697 T1310 T1307 punct /,Hdhex4
R698 T1311 T1307 appos Hdhex4,Hdhex4
R699 T1312 T1311 punct /,Hdhex4
R700 T1313 T1311 nummod 5,Hdhex4
R701 T1314 T1315 mark that,affect
R702 T1315 T1302 ccomp affect,reveals
R703 T1316 T1317 amod homozygous,inactivation
R704 T1317 T1315 nsubj inactivation,affect
R705 T1318 T1317 prep of,inactivation
R706 T1319 T1320 det the,gene
R707 T1320 T1318 pobj gene,of
R708 T1321 T1320 compound mouse,gene
R709 T1322 T1320 compound HD,gene
R710 T1323 T1315 aux does,affect
R711 T1324 T1315 neg not,affect
R712 T1325 T1315 advmod overtly,affect
R713 T1326 T1315 dobj development,affect
R714 T1327 T1315 prep until,affect
R715 T1328 T1327 pobj E7.0,until
R716 T1329 T1302 punct .,reveals
R717 T1331 T1332 prep By,exhibit
R718 T1333 T1331 pobj E7.5,By
R719 T1334 T1332 punct ", ",exhibit
R720 T1335 T1336 compound mutant,embryos
R721 T1336 T1332 nsubj embryos,exhibit
R722 T1337 T1338 det a,streak
R723 T1338 T1332 dobj streak,exhibit
R724 T1339 T1338 amod shortened,streak
R725 T1340 T1338 amod primitive,streak
R726 T1341 T1338 punct ", ",streak
R727 T1342 T1343 amod reduced,size
R728 T1343 T1338 appos size,streak
R729 T1344 T1332 cc and,exhibit
R730 T1345 T1332 punct ", ",exhibit
R731 T1346 T1347 prep by,lack
R732 T1347 T1332 conj lack,exhibit
R733 T1348 T1346 pobj morphology,by
R734 T1349 T1347 punct ", ",lack
R735 T1350 T1351 det a,node
R736 T1351 T1347 dobj node,lack
R737 T1352 T1351 cc and,node
R738 T1353 T1354 compound head,folds
R739 T1354 T1351 conj folds,node
R740 T1355 T1332 punct .,exhibit
R741 T1357 T1358 nsubjpass Mutants,resorbed
R742 T1359 T1358 auxpass are,resorbed
R743 T1360 T1358 advmod rapidly,resorbed
R744 T1361 T1358 prep by,resorbed
R745 T1362 T1361 pobj E8.0,by
R746 T1363 T1364 punct [,10
R747 T1364 T1358 parataxis 10,resorbed
R748 T1365 T1364 punct ],10
R749 T1366 T1358 punct .,resorbed
R750 T1368 T1369 advmod Importantly,rescues
R751 T1370 T1369 punct ", ",rescues
R752 T1371 T1372 det the,expression
R753 T1372 T1369 nsubj expression,rescues
R754 T1373 T1372 prep of,expression
R755 T1374 T1373 pobj huntingtin,of
R756 T1375 T1376 advmod only,in
R757 T1376 T1372 prep in,expression
R758 T1377 T1378 amod extraembryonic,tissues
R759 T1378 T1376 pobj tissues,in
R760 T1379 T1372 prep in,expression
R761 T1380 T1379 pobj chimeras,in
R762 T1381 T1382 det this,phenotype
R763 T1382 T1369 dobj phenotype,rescues
R764 T1383 T1382 compound gastrulation,phenotype
R765 T1384 T1369 punct ", ",rescues
R766 T1385 T1369 advcl suggesting,rescues
R767 T1386 T1387 mark that,required
R768 T1387 T1385 ccomp required,suggesting
R769 T1388 T1387 nsubjpass huntingtin,required
R770 T1389 T1387 auxpass is,required
R771 T1390 T1391 advmod only,in
R772 T1391 T1387 prep in,required
R773 T1392 T1391 pobj cells,in
R774 T1393 T1392 prep of,cells
R775 T1394 T1395 det the,lineage
R776 T1395 T1393 pobj lineage,of
R777 T1396 T1395 amod extraembryonic,lineage
R778 T1397 T1387 cc and,required
R779 T1398 T1387 conj acts,required
R780 T1399 T1398 prep in,acts
R781 T1400 T1401 det a,manner
R782 T1401 T1399 pobj manner,in
R783 T1402 T1403 npadvmod cell,non-autonomous
R784 T1403 T1401 amod non-autonomous,manner
R785 T1404 T1398 prep at,acts
R786 T1405 T1406 det this,stage
R787 T1406 T1404 pobj stage,at
R788 T1407 T1408 punct [,16
R789 T1408 T1398 parataxis 16,acts
R790 T1409 T1408 punct ],16
R791 T1410 T1369 punct .,rescues
R792 T1412 T1413 amod Extraembryonic,tissues
R793 T1413 T1414 nsubj tissues,are
R794 T1415 T1414 acomp essential,are
R795 T1416 T1415 prep for,essential
R796 T1417 T1416 pcomp supplying,for
R797 T1418 T1417 dobj nutrients,supplying
R798 T1419 T1418 cc and,nutrients
R799 T1420 T1418 conj signals,nutrients
R800 T1421 T1422 dep that,direct
R801 T1422 T1418 relcl direct,nutrients
R802 T1423 T1424 amod anterior,posterior
R803 T1424 T1426 amod posterior,formation
R804 T1425 T1424 punct /,posterior
R805 T1426 T1422 dobj formation,direct
R806 T1427 T1426 compound axis,formation
R807 T1428 T1426 cc and,formation
R808 T1429 T1426 conj patterning,formation
R809 T1430 T1422 prep in,direct
R810 T1431 T1432 det the,embryo
R811 T1432 T1430 pobj embryo,in
R812 T1433 T1432 amod developing,embryo
R813 T1434 T1435 punct (,reviewed
R814 T1435 T1422 parataxis reviewed,direct
R815 T1436 T1435 prep in,reviewed
R816 T1437 T1436 punct [,in
R817 T1438 T1436 pobj 17,in
R818 T1439 T1435 punct ],reviewed
R819 T1440 T1435 punct ),reviewed
R820 T1441 T1422 punct ", ",direct
R821 T1442 T1422 advcl implicating,direct
R822 T1443 T1442 dobj huntingtin,implicating
R823 T1444 T1442 prep in,implicating
R824 T1445 T1444 pobj either,in
R825 T1446 T1445 cc or,either
R826 T1447 T1445 conj both,either
R827 T1448 T1445 prep of,either
R828 T1449 T1450 det these,processes
R829 T1450 T1448 pobj processes,of
R830 T1451 T1414 punct .,are
R831 T1453 T1454 prep Of,investigated
R832 T1455 T1456 det these,possibilities
R833 T1456 T1453 pobj possibilities,Of
R834 T1457 T1454 punct ", ",investigated
R835 T1458 T1459 det the,role
R836 T1459 T1454 nsubjpass role,investigated
R837 T1460 T1459 amod nutritive,role
R838 T1461 T1454 aux has,investigated
R839 T1462 T1454 auxpass been,investigated
R840 T1463 T1464 advmod more,extensively
R841 T1464 T1454 advmod extensively,investigated
R842 T1465 T1454 punct .,investigated
R843 T1467 T1468 advmod However,display
R844 T1469 T1468 punct ", ",display
R845 T1470 T1471 npadvmod huntingtin,deficient
R846 T1471 T1472 amod deficient,embryos
R847 T1472 T1468 nsubj embryos,display
R848 T1473 T1468 aux do,display
R849 T1474 T1468 neg not,display
R850 T1475 T1476 amod obvious,defects
R851 T1476 T1468 dobj defects,display
R852 T1477 T1476 amod visceral,defects
R853 T1478 T1476 compound endoderm,defects
R854 T1479 T1468 punct ", ",display
R855 T1480 T1468 prep with,display
R856 T1481 T1482 det the,exception
R857 T1482 T1480 pobj exception,with
R858 T1483 T1482 amod notable,exception
R859 T1484 T1482 prep of,exception
R860 T1485 T1486 amod compromised,transport
R861 T1486 T1484 pobj transport,of
R862 T1487 T1486 compound iron,transport
R863 T1488 T1486 prep in,transport
R864 T1489 T1490 amod later,mutants
R865 T1490 T1488 pobj mutants,in
R866 T1491 T1490 compound stage,mutants
R867 T1492 T1468 punct ", ",display
R868 T1493 T1494 mark although,is
R869 T1494 T1468 advcl is,display
R870 T1495 T1496 compound iron,uptake
R871 T1496 T1494 nsubj uptake,is
R872 T1497 T1494 acomp undisturbed,is
R873 T1498 T1499 punct [,16
R874 T1499 T1494 parataxis 16,is
R875 T1500 T1499 punct ],16
R876 T1501 T1494 cc and,is
R877 T1502 T1503 nsubjpass endocytosis,impaired
R878 T1503 T1494 conj impaired,is
R879 T1504 T1503 auxpass is,impaired
R880 T1505 T1503 neg not,impaired
R881 T1506 T1503 prep in,impaired
R882 T1507 T1508 npadvmod huntingtin,deficient
R883 T1508 T1509 amod deficient,embryos
R884 T1509 T1506 pobj embryos,in
R885 T1510 T1509 cc or,embryos
R886 T1511 T1512 amod embryonic,cells
R887 T1512 T1509 conj cells,embryos
R888 T1513 T1512 compound stem,cells
R889 T1514 T1515 punct [,18
R890 T1515 T1503 parataxis 18,impaired
R891 T1516 T1515 nummod 16,18
R892 T1517 T1515 punct ",",18
R893 T1518 T1515 punct ],18
R894 T1519 T1468 punct .,display
R895 T1521 T1522 prep By,shuttles
R896 T1523 T1524 det the,token
R897 T1524 T1521 pobj token,By
R898 T1525 T1524 amod same,token
R899 T1526 T1522 punct ", ",shuttles
R900 T1527 T1522 nsubj huntingtin,shuttles
R901 T1528 T1522 prep through,shuttles
R902 T1529 T1530 det the,nucleus
R903 T1530 T1528 pobj nucleus,through
R904 T1531 T1530 punct ", ",nucleus
R905 T1532 T1533 advmod where,required
R906 T1533 T1530 relcl required,nucleus
R907 T1534 T1533 nsubjpass it,required
R908 T1535 T1533 auxpass is,required
R909 T1536 T1533 prep for,required
R910 T1537 T1538 amod proper,localization
R911 T1538 T1536 pobj localization,for
R912 T1539 T1538 amod nuclear,localization
R913 T1540 T1538 prep of,localization
R914 T1541 T1542 poss its,partners
R915 T1542 T1540 pobj partners,of
R916 T1543 T1544 compound transcription,factor
R917 T1544 T1542 compound factor,partners
R918 T1545 T1533 punct ", ",required
R919 T1546 T1533 advcl suggesting,required
R920 T1547 T1548 mark that,play
R921 T1548 T1546 ccomp play,suggesting
R922 T1549 T1548 nsubj huntingtin,play
R923 T1550 T1548 aux may,play
R924 T1551 T1552 det a,role
R925 T1552 T1548 dobj role,play
R926 T1553 T1548 prep in,play
R927 T1554 T1555 compound transcription,cascades
R928 T1555 T1553 pobj cascades,in
R929 T1556 T1548 prep in,play
R930 T1557 T1558 amod extraembryonic,tissues
R931 T1558 T1556 pobj tissues,in
R932 T1559 T1560 dep that,pattern
R933 T1560 T1558 relcl pattern,tissues
R934 T1561 T1562 det the,embryo
R935 T1562 T1560 dobj embryo,pattern
R936 T1563 T1564 punct [,18
R937 T1564 T1546 parataxis 18,suggesting
R938 T1565 T1564 punct ],18
R939 T1566 T1522 punct .,shuttles
R940 T1568 T1569 advmod Therefore,examined
R941 T1570 T1569 punct ", ",examined
R942 T1571 T1569 nsubj we,examined
R943 T1572 T1569 aux have,examined
R944 T1573 T1574 det this,hypothesis
R945 T1574 T1569 dobj hypothesis,examined
R946 T1575 T1569 punct ", ",examined
R947 T1576 T1569 prep by,examined
R948 T1577 T1576 pcomp monitoring,by
R949 T1578 T1579 det the,expression
R950 T1579 T1577 dobj expression,monitoring
R951 T1580 T1579 prep of,expression
R952 T1581 T1580 pobj genes,of
R953 T1582 T1583 dep that,determine
R954 T1583 T1581 relcl determine,genes
R955 T1584 T1585 amod normal,patterning
R956 T1585 T1583 dobj patterning,determine
R957 T1586 T1585 amod embryonic,patterning
R958 T1587 T1585 cc and,patterning
R959 T1588 T1585 conj morphogenesis,patterning
R960 T1589 T1583 prep in,determine
R961 T1590 T1591 nmod Hdhex4,embryos
R962 T1591 T1589 pobj embryos,in
R963 T1592 T1590 punct /,Hdhex4
R964 T1593 T1590 nummod 5,Hdhex4
R965 T1594 T1590 punct /,Hdhex4
R966 T1595 T1590 appos Hdhex4,Hdhex4
R967 T1596 T1595 punct /,Hdhex4
R968 T1597 T1595 nummod 5,Hdhex4
R969 T1598 T1599 npadvmod huntingtin,deficient
R970 T1599 T1591 amod deficient,embryos
R971 T1600 T1569 punct .,examined
R972 T1602 T1603 poss Our,results
R973 T1603 T1604 nsubj results,support
R974 T1605 T1604 cc and,support
R975 T1606 T1604 conj refine,support
R976 T1607 T1608 det the,hypothesis
R977 T1608 T1606 dobj hypothesis,refine
R978 T1609 T1606 punct ", ",refine
R979 T1610 T1606 conj indicating,refine
R980 T1611 T1612 mark that,required
R981 T1612 T1610 ccomp required,indicating
R982 T1613 T1612 nsubjpass huntingtin,required
R983 T1614 T1612 auxpass is,required
R984 T1615 T1612 prep for,required
R985 T1616 T1617 amod proper,patterning
R986 T1617 T1615 pobj patterning,for
R987 T1618 T1617 compound mesoderm,patterning
R988 T1619 T1615 cc and,for
R989 T1620 T1615 conj for,for
R990 T1621 T1622 amod normal,restriction
R991 T1622 T1620 pobj restriction,for
R992 T1623 T1622 amod regional,restriction
R993 T1624 T1622 prep of,restriction
R994 T1625 T1626 det the,expression
R995 T1626 T1624 pobj expression,of
R996 T1627 T1626 prep of,expression
R997 T1628 T1629 det a,subset
R998 T1629 T1627 pobj subset,of
R999 T1630 T1629 prep of,subset
R1000 T1631 T1632 nmod growth,factors
R1001 T1632 T1630 pobj factors,of
R1002 T1633 T1631 cc and,growth
R1003 T1634 T1631 conj transcription,growth
R1004 T1635 T1604 punct .,support

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T770 112-119 SO_EXT:sequence_repeat_unit_or_region denotes repeats
T771 127-129 PR_EXT:000008840 denotes HD
T772 154-163 CHEBI_SO_EXT:glutamine denotes glutamine
T773 191-197 SO_EXT:0000417 denotes domain
T774 198-205 CHEBI_PR_EXT:protein denotes protein
T775 213-223 PR_EXT:000008840 denotes huntingtin
T776 233-242 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T777 300-310 PR_EXT:000008840 denotes huntingtin
T778 322-331 CHEBI_SO_EXT:glutamine denotes glutamine
T779 372-380 UBERON:0002435 denotes striatal
T780 372-388 CL:0002613 denotes striatal neurons
T781 422-431 CHEBI_SO_EXT:glutamine denotes glutamine
T782 456-464 CHEBI_PR_EXT:protein denotes proteins
T783 486-499 CL:0000540 denotes neuronal cell
T784 495-499 CL_GO_EXT:cell denotes cell
T785 495-511 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes cell populations
T786 532-541 CHEBI_SO_EXT:glutamine denotes glutamine
T787 616-624 UBERON:0002435 denotes striatal
T788 625-629 CL_GO_EXT:cell denotes cell
T789 653-662 CHEBI_SO_EXT:glutamine denotes glutamine
T790 691-701 PR_EXT:000008840 denotes huntingtin
T791 739-749 PR_EXT:000008840 denotes huntingtin
T792 763-774 GO_UBERON_EXT:cellular_component_or_cell_part denotes subcellular
T793 766-774 CL_GO_EXT:cell denotes cellular
T794 803-813 PR_EXT:000008840 denotes Huntingtin
T795 868-874 SO_EXT:0000417 denotes domain
T796 875-883 GO_EXT:0032947 denotes scaffold
T797 908-916 _FRAGMENT denotes assembly
T798 955-957 _FRAGMENT denotes of
T799 964-981 GO:0006461 denotes protein complexes
T800 934-945 GO_UBERON_EXT:cellular_component_or_cell_part denotes subcellular
T801 937-945 CL_GO_EXT:cell denotes cellular
T802 946-957 _FRAGMENT denotes location of
T803 964-981 GO:0031503 denotes protein complexes
T804 964-971 CHEBI_PR_EXT:protein denotes protein
T805 964-981 GO:0043234 denotes protein complexes
T806 989-999 PR_EXT:000008840 denotes Huntingtin
T807 1026-1037 GO:0005737 denotes cytoplasmic
T808 1042-1049 GO:0005634 denotes nuclear
T809 1050-1057 CHEBI_PR_EXT:protein denotes protein
T810 1058-1065 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T811 1097-1107 PR_EXT:000008840 denotes huntingtin
T812 1140-1148 CL_GO_EXT:cell denotes cellular
T813 1140-1158 GO:0009987 denotes cellular processes
T814 1175-1186 GO_EXT:biological_routing_or_transport denotes trafficking
T815 1190-1196 GO_EXT:biological_growth_entity_or_process denotes growth
T816 1190-1203 GO_EXT:0008083 denotes growth factor
T817 1190-1213 GO:0036454 denotes growth factor complexes
T818 1217-1221 SO_EXT:0000704 denotes gene
T819 1222-1235 GO_EXT:transcription denotes transcription
T820 1303-1313 PR_EXT:000008840 denotes huntingtin
T821 1377-1386 CHEBI_SO_EXT:glutamine denotes glutamine
T822 1387-1395 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T823 1417-1427 PR_EXT:000008840 denotes huntingtin
T824 1438-1447 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T825 1452-1460 CL_GO_EXT:cell denotes cellular
T826 1542-1552 PR_EXT:000008840 denotes huntingtin
T827 1603-1613 PR_EXT:000008840 denotes huntingtin
T828 1632-1637 NCBITaxon:10088 denotes mouse
T829 1659-1664 NCBITaxon:10088 denotes mouse
T830 1668-1672 SO_EXT:0000704 denotes gene
T831 1674-1677 PR_EXT:000008840 denotes Hdh
T832 1694-1704 PR_EXT:000008840 denotes huntingtin
T833 1725-1729 CL_GO_EXT:cell denotes cell
T834 1773-1778 NCBITaxon:10088 denotes mouse
T835 1779-1788 UBERON:0000922 denotes embryonic
T836 1779-1799 CL:0002322 denotes embryonic stem cells
T837 1794-1799 CL_GO_EXT:cell denotes cells
T838 1804-1811 CL:0000540 denotes neurons
T839 1822-1832 PR_EXT:000008840 denotes huntingtin
T840 1851-1861 PR_EXT:000008840 denotes huntingtin
T841 1892-1900 NCBITaxon:1 denotes organism
T842 1912-1921 NCBITaxon:40674 denotes mammalian
T843 1922-1931 UBERON:0000922 denotes embryonic
T844 1922-1943 GO:0009790 denotes embryonic development
T845 1973-1983 PR_EXT:000008840 denotes huntingtin
T846 2023-2035 GO:0007369 denotes gastrulation
T847 2063-2073 PR_EXT:000008840 denotes huntingtin
T848 2101-2113 GO:0022008 denotes neurogenesis
T849 2118-2127 UBERON:0012101 denotes perinatal
T850 2122-2127 GO:0007567 denotes natal
T851 2128-2137 GO_EXT:fatality_or_lethality denotes lethality
T852 2156-2166 PR_EXT:000008840 denotes huntingtin
T853 2177-2180 PR_EXT:000008840 denotes Hdh
T854 2186-2189 PR_EXT:000008840 denotes Hdh
T855 2195-2202 UBERON:0000922 denotes embryos
T856 2247-2252 NCBITaxon:10088 denotes mouse
T857 2253-2255 PR_EXT:000008840 denotes HD
T858 2256-2260 SO_EXT:0000704 denotes gene
T859 2318-2324 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T860 2325-2332 UBERON:0000922 denotes embryos
T861 2353-2369 UBERON:0004341 denotes primitive streak
T862 2411-2415 UBERON:0003062 denotes node
T863 2420-2430 UBERON:0009746 denotes head folds
T864 2432-2439 SO_EXT:sequence_altered_entity denotes Mutants
T865 2492-2502 GO:0010467 denotes expression
T866 2506-2516 PR_EXT:000008840 denotes huntingtin
T867 2525-2547 UBERON:0005292 denotes extraembryonic tissues
T868 2560-2567 SO_EXT:sequence_rescue_process denotes rescues
T869 2573-2585 GO:0007369 denotes gastrulation
T870 2613-2623 PR_EXT:000008840 denotes huntingtin
T871 2644-2649 CL_GO_EXT:cell denotes cells
T872 2662-2671 UBERON:0000922 denotes embryonic
T873 2694-2698 CL_GO_EXT:cell denotes cell
T874 2741-2763 UBERON:0005292 denotes Extraembryonic tissues
T875 2792-2801 CHEBI_EXT:33284 denotes nutrients
T876 2819-2825 GO_EXT:biological_direction_or_guidance denotes direct
T877 2826-2859 _FRAGMENT denotes anterior/posterior axis formation
T878 2875-2877 _FRAGMENT denotes in
T879 2893-2899 GO:0008595 denotes embryo
T880 2864-2874 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterning
T881 2893-2899 UBERON:0000922 denotes embryo
T882 2932-2942 PR_EXT:000008840 denotes huntingtin
T883 3073-3083 PR_EXT:000008840 denotes huntingtin
T884 3094-3101 UBERON:0000922 denotes embryos
T885 3125-3142 UBERON:0004877 denotes visceral endoderm
T886 3194-3198 CHEBI_EXT:iron denotes iron
T887 3194-3208 GO:0006826 denotes iron transport
T888 3224-3231 SO_EXT:sequence_altered_entity denotes mutants
T889 3242-3246 CHEBI_EXT:iron denotes iron
T890 3278-3289 GO:0006897 denotes endocytosis
T891 3309-3319 PR_EXT:000008840 denotes huntingtin
T892 3330-3337 UBERON:0000922 denotes embryos
T893 3341-3350 UBERON:0000922 denotes embryonic
T894 3341-3361 CL:0002322 denotes embryonic stem cells
T895 3356-3361 CL_GO_EXT:cell denotes cells
T896 3390-3400 PR_EXT:000008840 denotes huntingtin
T897 3401-3409 GO_EXT:biological_movement_or_translocation_process denotes shuttles
T898 3422-3429 GO:0005634 denotes nucleus
T899 3463-3470 GO:0005634 denotes nuclear
T900 3471-3483 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T901 3491-3504 GO_EXT:transcription denotes transcription
T902 3491-3511 GO_EXT:transcription_factor denotes transcription factor
T903 3538-3548 PR_EXT:000008840 denotes huntingtin
T904 3568-3581 GO_EXT:transcription denotes transcription
T905 3594-3616 UBERON:0005292 denotes extraembryonic tissues
T906 3622-3629 GO_PATO_EXT:biological_patterning_process_or_quality denotes pattern
T907 3634-3640 UBERON:0000922 denotes embryo
T908 3710-3720 GO:0010467 denotes expression
T909 3724-3729 SO_EXT:0000704 denotes genes
T910 3752-3761 UBERON:0000922 denotes embryonic
T911 3752-3761 _FRAGMENT denotes embryonic
T912 3777-3790 GO:0048598 denotes morphogenesis
T913 3762-3772 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterning
T914 3794-3797 PR_EXT:000008840 denotes Hdh
T915 3803-3806 PR_EXT:000008840 denotes Hdh
T916 3812-3822 PR_EXT:000008840 denotes huntingtin
T917 3833-3840 UBERON:0000922 denotes embryos
T918 3905-3915 PR_EXT:000008840 denotes huntingtin
T919 3939-3947 UBERON:0000926 denotes mesoderm
T920 3948-3958 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterning
T921 4002-4012 GO:0010467 denotes expression
T922 4028-4034 GO_EXT:biological_growth_entity_or_process denotes growth
T923 4028-4034 _FRAGMENT denotes growth
T924 4053-4060 GO_EXT:0008083 denotes factors
T925 4039-4052 GO_EXT:transcription denotes transcription
T926 4039-4060 GO_EXT:transcription_factor denotes transcription factors
R330 T798 T797 _lexicallyChainedTo of,assembly
R331 T799 T798 _lexicallyChainedTo protein complexes,of
R332 T803 T802 _lexicallyChainedTo protein complexes,location of
R333 T878 T877 _lexicallyChainedTo in,anterior/posterior axis formation
R334 T879 T878 _lexicallyChainedTo embryo,in
R335 T912 T911 _lexicallyChainedTo morphogenesis,embryonic
R336 T924 T923 _lexicallyChainedTo factors,growth

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T672 300-310 PR:000008840 denotes huntingtin
T673 372-380 UBERON:0002435 denotes striatal
T674 372-388 CL:0002613 denotes striatal neurons
T675 486-499 CL:0000540 denotes neuronal cell
T676 616-624 UBERON:0002435 denotes striatal
T677 691-701 PR:000008840 denotes huntingtin
T678 739-749 PR:000008840 denotes huntingtin
T679 803-813 PR:000008840 denotes Huntingtin
T680 868-874 SO:0000417 denotes domain
T681 908-916 _FRAGMENT denotes assembly
T682 955-957 _FRAGMENT denotes of
T683 964-981 GO:0006461 denotes protein complexes
T684 946-957 _FRAGMENT denotes location of
T685 964-981 GO:0031503 denotes protein complexes
T686 964-981 GO:0043234 denotes protein complexes
T687 989-999 PR:000008840 denotes Huntingtin
T688 1026-1037 GO:0005737 denotes cytoplasmic
T689 1042-1049 GO:0005634 denotes nuclear
T690 1097-1107 PR:000008840 denotes huntingtin
T691 1140-1158 GO:0009987 denotes cellular processes
T692 1190-1213 GO:0036454 denotes growth factor complexes
T693 1217-1221 SO:0000704 denotes gene
T694 1303-1313 PR:000008840 denotes huntingtin
T695 1417-1427 PR:000008840 denotes huntingtin
T696 1542-1552 PR:000008840 denotes huntingtin
T697 1603-1613 PR:000008840 denotes huntingtin
T698 1632-1637 NCBITaxon:10088 denotes mouse
T699 1659-1664 NCBITaxon:10088 denotes mouse
T700 1668-1672 SO:0000704 denotes gene
T701 1674-1677 PR:000008840 denotes Hdh
T702 1694-1704 PR:000008840 denotes huntingtin
T703 1773-1778 NCBITaxon:10088 denotes mouse
T704 1779-1788 UBERON:0000922 denotes embryonic
T705 1779-1799 CL:0002322 denotes embryonic stem cells
T706 1804-1811 CL:0000540 denotes neurons
T707 1822-1832 PR:000008840 denotes huntingtin
T708 1851-1861 PR:000008840 denotes huntingtin
T709 1892-1900 NCBITaxon:1 denotes organism
T710 1912-1921 NCBITaxon:40674 denotes mammalian
T711 1922-1931 UBERON:0000922 denotes embryonic
T712 1922-1943 GO:0009790 denotes embryonic development
T713 1973-1983 PR:000008840 denotes huntingtin
T714 2023-2035 GO:0007369 denotes gastrulation
T715 2063-2073 PR:000008840 denotes huntingtin
T716 2101-2113 GO:0022008 denotes neurogenesis
T717 2118-2127 UBERON:0012101 denotes perinatal
T718 2122-2127 GO:0007567 denotes natal
T719 2156-2166 PR:000008840 denotes huntingtin
T720 2177-2180 PR:000008840 denotes Hdh
T721 2186-2189 PR:000008840 denotes Hdh
T722 2195-2202 UBERON:0000922 denotes embryos
T723 2247-2252 NCBITaxon:10088 denotes mouse
T724 2253-2255 PR:000008840 denotes HD
T725 2256-2260 SO:0000704 denotes gene
T726 2325-2332 UBERON:0000922 denotes embryos
T727 2353-2369 UBERON:0004341 denotes primitive streak
T728 2411-2415 UBERON:0003062 denotes node
T729 2420-2430 UBERON:0009746 denotes head folds
T730 2492-2502 GO:0010467 denotes expression
T731 2506-2516 PR:000008840 denotes huntingtin
T732 2525-2547 UBERON:0005292 denotes extraembryonic tissues
T733 2573-2585 GO:0007369 denotes gastrulation
T734 2613-2623 PR:000008840 denotes huntingtin
T735 2662-2671 UBERON:0000922 denotes embryonic
T736 2741-2763 UBERON:0005292 denotes Extraembryonic tissues
T737 2792-2801 CHEBI:33284 denotes nutrients
T738 2826-2859 _FRAGMENT denotes anterior/posterior axis formation
T739 2875-2877 _FRAGMENT denotes in
T740 2893-2899 GO:0008595 denotes embryo
T741 2893-2899 UBERON:0000922 denotes embryo
T742 2932-2942 PR:000008840 denotes huntingtin
T743 3073-3083 PR:000008840 denotes huntingtin
T744 3094-3101 UBERON:0000922 denotes embryos
T745 3125-3142 UBERON:0004877 denotes visceral endoderm
T746 3194-3208 GO:0006826 denotes iron transport
T747 3278-3289 GO:0006897 denotes endocytosis
T748 3309-3319 PR:000008840 denotes huntingtin
T749 3330-3337 UBERON:0000922 denotes embryos
T750 3341-3350 UBERON:0000922 denotes embryonic
T751 3341-3361 CL:0002322 denotes embryonic stem cells
T752 3390-3400 PR:000008840 denotes huntingtin
T753 3422-3429 GO:0005634 denotes nucleus
T754 3463-3470 GO:0005634 denotes nuclear
T755 3538-3548 PR:000008840 denotes huntingtin
T756 3594-3616 UBERON:0005292 denotes extraembryonic tissues
T757 3634-3640 UBERON:0000922 denotes embryo
T758 3710-3720 GO:0010467 denotes expression
T759 3724-3729 SO:0000704 denotes genes
T760 3752-3761 UBERON:0000922 denotes embryonic
T761 3752-3761 _FRAGMENT denotes embryonic
T762 3777-3790 GO:0048598 denotes morphogenesis
T763 3794-3797 PR:000008840 denotes Hdh
T764 3803-3806 PR:000008840 denotes Hdh
T669 127-129 PR:000008840 denotes HD
T670 191-197 SO:0000417 denotes domain
T671 213-223 PR:000008840 denotes huntingtin
T765 3812-3822 PR:000008840 denotes huntingtin
T766 3833-3840 UBERON:0000922 denotes embryos
T767 3905-3915 PR:000008840 denotes huntingtin
T768 3939-3947 UBERON:0000926 denotes mesoderm
T769 4002-4012 GO:0010467 denotes expression
R324 T682 T681 _lexicallyChainedTo of,assembly
R325 T683 T682 _lexicallyChainedTo protein complexes,of
R326 T685 T684 _lexicallyChainedTo protein complexes,location of
R327 T739 T738 _lexicallyChainedTo in,anterior/posterior axis formation
R328 T740 T739 _lexicallyChainedTo embryo,in
R329 T762 T761 _lexicallyChainedTo morphogenesis,embryonic