
PMC:1189074 / 4977-5703
Annnotations
craft-sa-dev
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1088 | 11-17 | VBZ | denotes | arises |
T1091 | 5-10 | NN | denotes | codon |
T1094 | 0-4 | NN | denotes | stop |
T1095 | 18-23 | IN | denotes | after |
T1096 | 24-35 | NN | denotes | translation |
T1097 | 36-38 | IN | denotes | of |
T1098 | 39-43 | RB | denotes | only |
T1099 | 44-49 | CD | denotes | seven |
T1100 | 56-61 | NNS | denotes | acids |
T1101 | 50-55 | NN | denotes | amino |
T1102 | 62-66 | IN | denotes | from |
T1103 | 67-70 | DT | denotes | the |
T1104 | 82-86 | NN | denotes | exon |
T1105 | 71-81 | VBN | denotes | duplicated |
T1106 | 87-88 | CD | denotes | 8 |
T1107 | 88-89 | . | denotes | . |
T1108 | 89-259 | sentence | denotes | The resulting MCAD monomer is missing the C-terminal domain α-helixes that are responsible for making intersubunit contacts to generate the functional MCAD homotetramer. |
T1109 | 90-93 | DT | denotes | The |
T1110 | 109-116 | NN | denotes | monomer |
T1111 | 94-103 | VBG | denotes | resulting |
T1112 | 104-108 | NN | denotes | MCAD |
T1113 | 120-127 | VBG | denotes | missing |
T1114 | 117-119 | VBZ | denotes | is |
T1115 | 128-131 | DT | denotes | the |
T1116 | 152-159 | NNS | denotes | helixes |
T1117 | 132-133 | NN | denotes | C |
T1118 | 134-142 | JJ | denotes | terminal |
T1119 | 133-134 | HYPH | denotes | - |
T1120 | 143-149 | NN | denotes | domain |
T1121 | 150-151 | NN | denotes | α |
T1122 | 151-152 | HYPH | denotes | - |
T1123 | 160-164 | WDT | denotes | that |
T1124 | 165-168 | VBP | denotes | are |
T1125 | 169-180 | JJ | denotes | responsible |
T1126 | 181-184 | IN | denotes | for |
T1127 | 185-191 | VBG | denotes | making |
T1128 | 192-204 | NN | denotes | intersubunit |
T1129 | 205-213 | NNS | denotes | contacts |
T1130 | 214-216 | TO | denotes | to |
T1131 | 217-225 | VB | denotes | generate |
T1132 | 226-229 | DT | denotes | the |
T1133 | 246-258 | NN | denotes | homotetramer |
T1134 | 230-240 | JJ | denotes | functional |
T1135 | 241-245 | NN | denotes | MCAD |
T1136 | 258-259 | . | denotes | . |
T7247 | 270-278 | NN | denotes | Strategy |
T7248 | 279-282 | IN | denotes | for |
T7249 | 283-293 | NN | denotes | Disruption |
T7250 | 294-296 | IN | denotes | of |
T7251 | 297-300 | DT | denotes | the |
T7252 | 313-317 | NN | denotes | Gene |
T7253 | 301-306 | NN | denotes | Mouse |
T7254 | 307-312 | NN | denotes | Acadm |
T7255 | 317-435 | sentence | denotes | (A) The MCAD IV2 insertion targeting vector with a deleted 1.3-kb region encompassing exon 10 and flanking sequences. |
T7256 | 318-319 | -LRB- | denotes | ( |
T7257 | 319-320 | LS | denotes | A |
T7258 | 355-361 | NN | denotes | vector |
T7259 | 320-321 | -RRB- | denotes | ) |
T7260 | 322-325 | DT | denotes | The |
T7261 | 326-330 | NN | denotes | MCAD |
T7262 | 335-344 | NN | denotes | insertion |
T7263 | 331-334 | NN | denotes | IV2 |
T7264 | 345-354 | NN | denotes | targeting |
T7265 | 362-366 | IN | denotes | with |
T7266 | 367-368 | DT | denotes | a |
T7267 | 384-390 | NN | denotes | region |
T7268 | 369-376 | VBN | denotes | deleted |
T7269 | 377-380 | CD | denotes | 1.3 |
T7270 | 381-383 | NN | denotes | kb |
T7271 | 380-381 | HYPH | denotes | - |
T7272 | 391-403 | VBG | denotes | encompassing |
T7273 | 404-408 | NN | denotes | exon |
T7274 | 409-411 | CD | denotes | 10 |
T7275 | 412-415 | CC | denotes | and |
T7276 | 416-424 | VBG | denotes | flanking |
T7277 | 425-434 | NNS | denotes | sequences |
T7278 | 434-435 | . | denotes | . |
T7279 | 435-599 | sentence | denotes | MCAD IV2 undergoes gap repair upon homologous recombination at the endogenous Acadm locus resulting in a duplication of exons 8, 9, and 10 at the disrupted allele. |
T7280 | 436-440 | NN | denotes | MCAD |
T7281 | 441-444 | NN | denotes | IV2 |
T7282 | 445-454 | VBZ | denotes | undergoes |
T7283 | 455-458 | NN | denotes | gap |
T7284 | 459-465 | NN | denotes | repair |
T7285 | 466-470 | IN | denotes | upon |
T7286 | 471-481 | JJ | denotes | homologous |
T7287 | 482-495 | NN | denotes | recombination |
T7288 | 496-498 | IN | denotes | at |
T7289 | 499-502 | DT | denotes | the |
T7290 | 520-525 | NN | denotes | locus |
T7291 | 503-513 | JJ | denotes | endogenous |
T7292 | 514-519 | NN | denotes | Acadm |
T7293 | 526-535 | VBG | denotes | resulting |
T7294 | 536-538 | IN | denotes | in |
T7295 | 539-540 | DT | denotes | a |
T7296 | 541-552 | NN | denotes | duplication |
T7297 | 553-555 | IN | denotes | of |
T7298 | 556-561 | NNS | denotes | exons |
T7299 | 562-563 | CD | denotes | 8 |
T7300 | 563-565 | , | denotes | , |
T7301 | 565-566 | CD | denotes | 9 |
T7302 | 566-568 | , | denotes | , |
T7303 | 568-571 | CC | denotes | and |
T7304 | 572-574 | CD | denotes | 10 |
T7305 | 575-577 | IN | denotes | at |
T7306 | 578-581 | DT | denotes | the |
T7307 | 592-598 | NN | denotes | allele |
T7308 | 582-591 | VBN | denotes | disrupted |
T7309 | 598-599 | . | denotes | . |
T7310 | 599-687 | sentence | denotes | (B) Southern blot analysis of EcoRI-digested genomic DNA from ES cells screened by PCR. |
T7311 | 600-601 | -LRB- | denotes | ( |
T7312 | 601-602 | LS | denotes | B |
T7313 | 618-626 | NN | denotes | analysis |
T7314 | 602-603 | -RRB- | denotes | ) |
T7315 | 604-612 | NNP | denotes | Southern |
T7316 | 613-617 | NN | denotes | blot |
T7317 | 627-629 | IN | denotes | of |
T7318 | 630-635 | NN | denotes | EcoRI |
T7319 | 636-644 | VBN | denotes | digested |
T7320 | 635-636 | HYPH | denotes | - |
T7321 | 653-656 | NN | denotes | DNA |
T7322 | 645-652 | JJ | denotes | genomic |
T7323 | 657-661 | IN | denotes | from |
T7324 | 662-664 | NN | denotes | ES |
T7325 | 665-670 | NNS | denotes | cells |
T7326 | 671-679 | VBN | denotes | screened |
T7327 | 680-682 | IN | denotes | by |
T7328 | 683-686 | NN | denotes | PCR |
T7329 | 686-687 | . | denotes | . |
T7331 | 688-693 | NN | denotes | Probe |
T7332 | 694-695 | NN | denotes | A |
T7334 | 695-697 | , | denotes | , |
T7335 | 697-698 | DT | denotes | a |
T7336 | 703-711 | NN | denotes | fragment |
T7337 | 699-702 | NN | denotes | DNA |
T7338 | 712-722 | VBG | denotes | consisting |
T7339 | 723-725 | IN | denotes | of |
R695 | T1091 | T1088 | nsubj | codon,arises |
R698 | T1094 | T1091 | compound | stop,codon |
R699 | T1095 | T1088 | prep | after,arises |
R700 | T1096 | T1095 | pobj | translation,after |
R701 | T1097 | T1096 | prep | of,translation |
R702 | T1098 | T1099 | advmod | only,seven |
R703 | T1099 | T1100 | nummod | seven,acids |
R704 | T1100 | T1097 | pobj | acids,of |
R705 | T1101 | T1100 | compound | amino,acids |
R706 | T1102 | T1100 | prep | from,acids |
R707 | T1103 | T1104 | det | the,exon |
R708 | T1104 | T1102 | pobj | exon,from |
R709 | T1105 | T1104 | amod | duplicated,exon |
R710 | T1106 | T1104 | nummod | 8,exon |
R711 | T1107 | T1088 | punct | .,arises |
R712 | T1109 | T1110 | det | The,monomer |
R713 | T1110 | T1113 | nsubj | monomer,missing |
R714 | T1111 | T1110 | amod | resulting,monomer |
R715 | T1112 | T1110 | compound | MCAD,monomer |
R716 | T1114 | T1113 | aux | is,missing |
R717 | T1115 | T1116 | det | the,helixes |
R718 | T1116 | T1113 | dobj | helixes,missing |
R719 | T1117 | T1118 | npadvmod | C,terminal |
R720 | T1118 | T1120 | amod | terminal,domain |
R721 | T1119 | T1118 | punct | -,terminal |
R722 | T1120 | T1116 | compound | domain,helixes |
R723 | T1121 | T1116 | compound | α,helixes |
R724 | T1122 | T1116 | punct | -,helixes |
R725 | T1123 | T1124 | dep | that,are |
R726 | T1124 | T1116 | relcl | are,helixes |
R727 | T1125 | T1124 | acomp | responsible,are |
R728 | T1126 | T1125 | prep | for,responsible |
R729 | T1127 | T1126 | pcomp | making,for |
R730 | T1128 | T1129 | compound | intersubunit,contacts |
R731 | T1129 | T1127 | dobj | contacts,making |
R732 | T1130 | T1131 | aux | to,generate |
R733 | T1131 | T1127 | advcl | generate,making |
R734 | T1132 | T1133 | det | the,homotetramer |
R735 | T1133 | T1131 | dobj | homotetramer,generate |
R736 | T1134 | T1133 | amod | functional,homotetramer |
R737 | T1135 | T1133 | compound | MCAD,homotetramer |
R738 | T1136 | T1113 | punct | .,missing |
R4678 | T7248 | T7247 | prep | for,Strategy |
R4679 | T7249 | T7248 | pobj | Disruption,for |
R4680 | T7250 | T7249 | prep | of,Disruption |
R4681 | T7251 | T7252 | det | the,Gene |
R4682 | T7252 | T7250 | pobj | Gene,of |
R4683 | T7253 | T7252 | compound | Mouse,Gene |
R4684 | T7254 | T7252 | compound | Acadm,Gene |
R4685 | T7256 | T7257 | punct | (,A |
R4686 | T7257 | T7258 | meta | A,vector |
R4687 | T7259 | T7257 | punct | ),A |
R4688 | T7260 | T7258 | det | The,vector |
R4689 | T7261 | T7262 | compound | MCAD,insertion |
R4690 | T7262 | T7258 | compound | insertion,vector |
R4691 | T7263 | T7262 | compound | IV2,insertion |
R4692 | T7264 | T7258 | compound | targeting,vector |
R4693 | T7265 | T7258 | prep | with,vector |
R4694 | T7266 | T7267 | det | a,region |
R4695 | T7267 | T7265 | pobj | region,with |
R4696 | T7268 | T7267 | amod | deleted,region |
R4697 | T7269 | T7270 | nummod | 1.3,kb |
R4698 | T7270 | T7267 | compound | kb,region |
R4699 | T7271 | T7270 | punct | -,kb |
R4700 | T7272 | T7267 | acl | encompassing,region |
R4701 | T7273 | T7272 | dobj | exon,encompassing |
R4702 | T7274 | T7273 | nummod | 10,exon |
R4703 | T7275 | T7273 | cc | and,exon |
R4704 | T7276 | T7277 | amod | flanking,sequences |
R4705 | T7277 | T7273 | conj | sequences,exon |
R4706 | T7278 | T7258 | punct | .,vector |
R4707 | T7280 | T7281 | compound | MCAD,IV2 |
R4708 | T7281 | T7282 | nsubj | IV2,undergoes |
R4709 | T7283 | T7284 | compound | gap,repair |
R4710 | T7284 | T7282 | dobj | repair,undergoes |
R4711 | T7285 | T7282 | prep | upon,undergoes |
R4712 | T7286 | T7287 | amod | homologous,recombination |
R4713 | T7287 | T7285 | pobj | recombination,upon |
R4714 | T7288 | T7282 | prep | at,undergoes |
R4715 | T7289 | T7290 | det | the,locus |
R4716 | T7290 | T7288 | pobj | locus,at |
R4717 | T7291 | T7290 | amod | endogenous,locus |
R4718 | T7292 | T7290 | compound | Acadm,locus |
R4719 | T7293 | T7282 | advcl | resulting,undergoes |
R4720 | T7294 | T7293 | prep | in,resulting |
R4721 | T7295 | T7296 | det | a,duplication |
R4722 | T7296 | T7294 | pobj | duplication,in |
R4723 | T7297 | T7296 | prep | of,duplication |
R4724 | T7298 | T7299 | nmod | exons,8 |
R4725 | T7299 | T7297 | pobj | 8,of |
R4726 | T7300 | T7299 | punct | ", ",8 |
R4727 | T7301 | T7299 | conj | 9,8 |
R4728 | T7302 | T7301 | punct | ", ",9 |
R4729 | T7303 | T7301 | cc | and,9 |
R4730 | T7304 | T7301 | conj | 10,9 |
R4731 | T7305 | T7296 | prep | at,duplication |
R4732 | T7306 | T7307 | det | the,allele |
R4733 | T7307 | T7305 | pobj | allele,at |
R4734 | T7308 | T7307 | amod | disrupted,allele |
R4735 | T7309 | T7282 | punct | .,undergoes |
R4736 | T7311 | T7312 | punct | (,B |
R4737 | T7312 | T7313 | meta | B,analysis |
R4738 | T7314 | T7312 | punct | ),B |
R4739 | T7315 | T7316 | compound | Southern,blot |
R4740 | T7316 | T7313 | compound | blot,analysis |
R4741 | T7317 | T7313 | prep | of,analysis |
R4742 | T7318 | T7319 | npadvmod | EcoRI,digested |
R4743 | T7319 | T7321 | amod | digested,DNA |
R4744 | T7320 | T7319 | punct | -,digested |
R4745 | T7321 | T7317 | pobj | DNA,of |
R4746 | T7322 | T7321 | amod | genomic,DNA |
R4747 | T7323 | T7321 | prep | from,DNA |
R4748 | T7324 | T7325 | compound | ES,cells |
R4749 | T7325 | T7323 | pobj | cells,from |
R4750 | T7326 | T7325 | acl | screened,cells |
R4751 | T7327 | T7326 | prep | by,screened |
R4752 | T7328 | T7327 | pobj | PCR,by |
R4753 | T7329 | T7313 | punct | .,analysis |
R4754 | T7331 | T7332 | compound | Probe,A |
R4756 | T7334 | T7332 | punct | ", ",A |
R4757 | T7335 | T7336 | det | a,fragment |
R4758 | T7336 | T7332 | appos | fragment,A |
R4759 | T7337 | T7336 | compound | DNA,fragment |
R4760 | T7338 | T7336 | acl | consisting,fragment |
R4761 | T7339 | T7338 | prep | of,consisting |
craft-ca-core-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1456 | 24-35 | GO:0006412 | denotes | translation |
T1457 | 82-86 | SO:0000147 | denotes | exon |
T1458 | 143-149 | SO:0000417 | denotes | domain |
T1459 | 150-159 | SO:0001117 | denotes | α-helixes |
T7397 | 301-306 | NCBITaxon:10088 | denotes | Mouse |
T7398 | 313-317 | SO:0000704 | denotes | Gene |
T7399 | 345-361 | SO:0001644 | denotes | targeting vector |
T7400 | 404-408 | SO:0000147 | denotes | exon |
T7401 | 416-424 | SO:0000357 | denotes | flanking |
T7402 | 556-561 | SO:0000147 | denotes | exons |
T7403 | 592-598 | SO:0001023 | denotes | allele |
T7404 | 645-652 | SO:0001026 | denotes | genomic |
T7405 | 662-670 | CL:0002322 | denotes | ES cells |
craft-ca-core-ex-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1510 | 24-35 | GO:0006412 | denotes | translation |
T1511 | 50-61 | CHEBI_SO_EXT:amino_acid | denotes | amino acids |
T1512 | 71-81 | SO_EXT:sequence_duplication_process | denotes | duplicated |
T1513 | 82-86 | SO_EXT:0000147 | denotes | exon |
T1514 | 104-108 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
T1515 | 132-142 | CHEBI_SO_EXT:C_terminus_or_C_terminal_region | denotes | C-terminal |
T1516 | 143-149 | SO_EXT:0000417 | denotes | domain |
T1517 | 150-159 | SO_EXT:0001117 | denotes | α-helixes |
T1518 | 241-245 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
T1519 | 250-258 | GO_EXT:tetrameric_macromolecular_complex | denotes | tetramer |
T7411 | 301-306 | NCBITaxon:10088 | denotes | Mouse |
T7412 | 307-312 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | Acadm |
T7413 | 313-317 | SO_EXT:0000704 | denotes | Gene |
T7414 | 326-330 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
T7415 | 335-344 | SO_EXT:sequence_insertion_entity_or_process | denotes | insertion |
T7416 | 345-361 | SO_EXT:0001644 | denotes | targeting vector |
T7417 | 369-376 | SO_EXT:sequence_deletion_process | denotes | deleted |
T7418 | 382-383 | CHEBI_SO_EXT:base | denotes | b |
T7419 | 404-408 | SO_EXT:0000147 | denotes | exon |
T7420 | 416-424 | SO:0000357 | denotes | flanking |
T7421 | 425-434 | SO_EXT:biological_sequence | denotes | sequences |
T7422 | 436-440 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
T7423 | 455-465 | GO_EXT:DNA_gap_repair | denotes | gap repair |
T7424 | 482-495 | GO_SO_EXT:sequence_rearrangement_process | denotes | recombination |
T7425 | 514-519 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | Acadm |
T7426 | 541-552 | SO_EXT:sequence_duplication_entity_or_process | denotes | duplication |
T7427 | 556-561 | SO_EXT:0000147 | denotes | exons |
T7428 | 592-598 | SO_EXT:0001023 | denotes | allele |
T7429 | 645-656 | SO_EXT:genomic_DNA | denotes | genomic DNA |
T7430 | 653-656 | CHEBI_SO_EXT:DNA | denotes | DNA |
T7431 | 662-670 | CL:0002322 | denotes | ES cells |
T7432 | 665-670 | CL_GO_EXT:cell | denotes | cells |
T7433 | 688-693 | CHEBI_SO_EXT:molecular_probe | denotes | Probe |
T7434 | 699-702 | CHEBI_SO_EXT:DNA | denotes | DNA |