PMC:1189074 / 4340-16229 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T964	9-13	NN	denotes	Gene
T965	14-23	NN	denotes	Targeting
T966	24-27	CC	denotes	and
T967	28-38	NN	denotes	Generation
T968	39-41	IN	denotes	of
T969	42-46	NN	denotes	MCAD
T970	47-56	JJ	denotes	Deficient
T971	46-47	HYPH	denotes	-
T972	57-61	NNS	denotes	Mice
T973	61-228	sentence	denotes	MCAD insertion vector (MCAD IV2) was designed to undergo gap repair of the 1.3-kb deleted region upon homologous recombination in 129P2 (129P2/OlaHsd) ES cells E14–1.
T974	62-66	NN	denotes	MCAD
T975	77-83	NN	denotes	vector
T976	67-76	NN	denotes	insertion
T977	99-107	VBN	denotes	designed
T978	84-85	-LRB-	denotes	(
T979	85-89	NN	denotes	MCAD
T980	90-93	NN	denotes	IV2
T981	93-94	-RRB-	denotes	)
T982	95-98	VBD	denotes	was
T983	108-110	TO	denotes	to
T984	111-118	VB	denotes	undergo
T985	119-122	NN	denotes	gap
T986	123-129	NN	denotes	repair
T987	130-132	IN	denotes	of
T988	133-136	DT	denotes	the
T989	152-158	NN	denotes	region
T990	137-140	CD	denotes	1.3
T991	141-143	NN	denotes	kb
T992	140-141	HYPH	denotes	-
T993	144-151	VBN	denotes	deleted
T994	159-163	IN	denotes	upon
T995	164-174	JJ	denotes	homologous
T996	175-188	NN	denotes	recombination
T997	189-191	IN	denotes	in
T998	192-197	NN	denotes	129P2
T999	216-221	NNS	denotes	cells
T1000	198-199	-LRB-	denotes	(
T1001	205-211	NN	denotes	OlaHsd
T1002	199-204	NN	denotes	129P2
T1003	204-205	HYPH	denotes	/
T1004	211-212	-RRB-	denotes	)
T1005	213-215	NN	denotes	ES
T1006	222-225	NN	denotes	E14
T1007	225-226	HYPH	denotes	–
T1008	226-227	CD	denotes	1
T1009	227-228	.	denotes	.
T1010	228-379	sentence	denotes	Correct targeting of the MCAD locus resulted in a duplication of exons 8, 9, and 10 and integration of flanking plasmid and Neo sequences (Figure 1A).
T1011	229-236	JJ	denotes	Correct
T1012	237-246	NN	denotes	targeting
T1013	265-273	VBD	denotes	resulted
T1014	247-249	IN	denotes	of
T1015	250-253	DT	denotes	the
T1016	259-264	NN	denotes	locus
T1017	254-258	NN	denotes	MCAD
T1018	274-276	IN	denotes	in
T1019	277-278	DT	denotes	a
T1020	279-290	NN	denotes	duplication
T1021	291-293	IN	denotes	of
T1022	294-299	NNS	denotes	exons
T1023	300-301	CD	denotes	8
T1024	301-303	,	denotes	,
T1025	303-304	CD	denotes	9
T1026	304-306	,	denotes	,
T1027	306-309	CC	denotes	and
T1028	310-312	CD	denotes	10
T1029	313-316	CC	denotes	and
T1030	317-328	NN	denotes	integration
T1031	329-331	IN	denotes	of
T1032	332-340	VBG	denotes	flanking
T1033	341-348	NN	denotes	plasmid
T1034	349-352	CC	denotes	and
T1035	353-356	NN	denotes	Neo
T1036	357-366	NNS	denotes	sequences
T1037	367-368	-LRB-	denotes	(
T1038	368-374	NN	denotes	Figure
T1039	375-377	CD	denotes	1A
T1040	377-378	-RRB-	denotes	)
T1041	378-379	.	denotes	.
T1042	379-463	sentence	denotes	The insertion vector was designed to duplicate exon 8, 9, and 10 at the MCAD locus.
T1043	380-383	DT	denotes	The
T1044	394-400	NN	denotes	vector
T1045	384-393	NN	denotes	insertion
T1046	405-413	VBN	denotes	designed
T1047	401-404	VBD	denotes	was
T1048	414-416	TO	denotes	to
T1049	417-426	VB	denotes	duplicate
T1050	427-431	NN	denotes	exon
T1051	432-433	CD	denotes	8
T1052	433-435	,	denotes	,
T1053	435-436	CD	denotes	9
T1054	436-438	,	denotes	,
T1055	438-441	CC	denotes	and
T1056	442-444	CD	denotes	10
T1057	445-447	IN	denotes	at
T1058	448-451	DT	denotes	the
T1059	457-462	NN	denotes	locus
T1060	452-456	NN	denotes	MCAD
T1061	462-463	.	denotes	.
T1062	463-602	sentence	denotes	Translation of the duplicated exon 8 region results in the formation of premature stop codons resulting in truncation of the MCAD monomer.
T1063	464-475	NN	denotes	Translation
T1064	508-515	VBZ	denotes	results
T1065	476-478	IN	denotes	of
T1066	479-482	DT	denotes	the
T1067	501-507	NN	denotes	region
T1068	483-493	VBN	denotes	duplicated
T1069	494-498	NN	denotes	exon
T1070	499-500	CD	denotes	8
T1071	516-518	IN	denotes	in
T1072	519-522	DT	denotes	the
T1073	523-532	NN	denotes	formation
T1074	533-535	IN	denotes	of
T1075	536-545	JJ	denotes	premature
T1076	551-557	NNS	denotes	codons
T1077	546-550	NN	denotes	stop
T1078	558-567	VBG	denotes	resulting
T1079	568-570	IN	denotes	in
T1080	571-581	NN	denotes	truncation
T1081	582-584	IN	denotes	of
T1082	585-588	DT	denotes	the
T1083	594-601	NN	denotes	monomer
T1084	589-593	NN	denotes	MCAD
T1085	601-602	.	denotes	.
T1086	602-726	sentence	denotes	Specifically, the first premature stop codon arises after translation of only seven amino acids from the duplicated exon 8.
T1087	603-615	RB	denotes	Specifically
T1088	648-654	VBZ	denotes	arises
T1089	615-617	,	denotes	,
T1090	617-620	DT	denotes	the
T1091	642-647	NN	denotes	codon
T1092	621-626	JJ	denotes	first
T1093	627-636	JJ	denotes	premature
T1094	637-641	NN	denotes	stop
T1095	655-660	IN	denotes	after
T1096	661-672	NN	denotes	translation
T1097	673-675	IN	denotes	of
T1098	676-680	RB	denotes	only
T1099	681-686	CD	denotes	seven
T1100	693-698	NNS	denotes	acids
T1101	687-692	NN	denotes	amino
T1102	699-703	IN	denotes	from
T1103	704-707	DT	denotes	the
T1104	719-723	NN	denotes	exon
T1105	708-718	VBN	denotes	duplicated
T1106	724-725	CD	denotes	8
T1107	725-726	.	denotes	.
T1108	726-896	sentence	denotes	The resulting MCAD monomer is missing the C-terminal domain α-helixes that are responsible for making intersubunit contacts to generate the functional MCAD homotetramer.
T1109	727-730	DT	denotes	The
T1110	746-753	NN	denotes	monomer
T1111	731-740	VBG	denotes	resulting
T1112	741-745	NN	denotes	MCAD
T1113	757-764	VBG	denotes	missing
T1114	754-756	VBZ	denotes	is
T1115	765-768	DT	denotes	the
T1116	789-796	NNS	denotes	helixes
T1117	769-770	NN	denotes	C
T1118	771-779	JJ	denotes	terminal
T1119	770-771	HYPH	denotes	-
T1120	780-786	NN	denotes	domain
T1121	787-788	NN	denotes	α
T1122	788-789	HYPH	denotes	-
T1123	797-801	WDT	denotes	that
T1124	802-805	VBP	denotes	are
T1125	806-817	JJ	denotes	responsible
T1126	818-821	IN	denotes	for
T1127	822-828	VBG	denotes	making
T1128	829-841	NN	denotes	intersubunit
T1129	842-850	NNS	denotes	contacts
T1130	851-853	TO	denotes	to
T1131	854-862	VB	denotes	generate
T1132	863-866	DT	denotes	the
T1133	883-895	NN	denotes	homotetramer
T1134	867-877	JJ	denotes	functional
T1135	878-882	NN	denotes	MCAD
T1136	895-896	.	denotes	.
T1137	896-1720	sentence	denotes	Figure 1 Strategy for Disruption of the Mouse Acadm Gene (A) The MCAD IV2 insertion targeting vector with a deleted 1.3-kb region encompassing exon 10 and flanking sequences. MCAD IV2 undergoes gap repair upon homologous recombination at the endogenous Acadm locus resulting in a duplication of exons 8, 9, and 10 at the disrupted allele. (B) Southern blot analysis of EcoRI-digested genomic DNA from ES cells screened by PCR. Probe A, a DNA fragment consisting of a portion of exon 10 that is not present in the targeting vector, hybridizes to an endogenous 3.1-kb fragment and, upon homologous recombination, to a 13.2-kb fragment. Lane 1 represents a wild-type ES cell line, and Lane 2 and 3 represent targeted ES cell lines. ES cell clones were screened by PCR (data not shown) and confirmed by Southern blot analysis.
T1138	1627-1629	NN	denotes	ES
T1139	1630-1634	NN	denotes	cell
T1140	1635-1641	NNS	denotes	clones
T1141	1647-1655	VBN	denotes	screened
T1142	1642-1646	VBD	denotes	were
T1143	1656-1658	IN	denotes	by
T1144	1659-1662	NN	denotes	PCR
T1145	1663-1664	-LRB-	denotes	(
T1146	1673-1678	VBN	denotes	shown
T1147	1664-1668	NNS	denotes	data
T1148	1669-1672	RB	denotes	not
T1149	1678-1679	-RRB-	denotes	)
T1150	1680-1683	CC	denotes	and
T1151	1684-1693	VBN	denotes	confirmed
T1152	1694-1696	IN	denotes	by
T1153	1697-1705	NNP	denotes	Southern
T1154	1706-1710	NN	denotes	blot
T1155	1711-1719	NN	denotes	analysis
T1156	1719-1720	.	denotes	.
T1157	1720-1960	sentence	denotes	Southern blot analysis used an exon 10 probe (probe A), not present in the targeting vector, hybridized to a 13.2-kb band in addition to the 3.1-kb endogenous band indicating targeted insertion of the vector at the Acadm locus (Figure 1B).
T1158	1721-1729	NNP	denotes	Southern
T1159	1730-1734	NN	denotes	blot
T1160	1735-1743	NN	denotes	analysis
T1161	1744-1748	VBD	denotes	used
T1162	1749-1751	DT	denotes	an
T1163	1760-1765	NN	denotes	probe
T1164	1752-1756	NN	denotes	exon
T1165	1757-1759	CD	denotes	10
T1166	1766-1767	-LRB-	denotes	(
T1167	1773-1774	NN	denotes	A
T1168	1767-1772	NN	denotes	probe
T1169	1774-1775	-RRB-	denotes	)
T1170	1775-1777	,	denotes	,
T1171	1777-1780	RB	denotes	not
T1172	1781-1788	JJ	denotes	present
T1173	1789-1791	IN	denotes	in
T1174	1792-1795	DT	denotes	the
T1175	1806-1812	NN	denotes	vector
T1176	1796-1805	NN	denotes	targeting
T1177	1812-1814	,	denotes	,
T1178	1814-1824	VBN	denotes	hybridized
T1179	1825-1827	IN	denotes	to
T1180	1828-1829	DT	denotes	a
T1181	1838-1842	NN	denotes	band
T1182	1830-1834	CD	denotes	13.2
T1183	1835-1837	NN	denotes	kb
T1184	1834-1835	HYPH	denotes	-
T1185	1843-1845	IN	denotes	in
T1186	1846-1854	NN	denotes	addition
T1187	1855-1857	IN	denotes	to
T1188	1858-1861	DT	denotes	the
T1189	1880-1884	NN	denotes	band
T1190	1862-1865	CD	denotes	3.1
T1191	1866-1868	NN	denotes	kb
T1192	1865-1866	HYPH	denotes	-
T1193	1869-1879	JJ	denotes	endogenous
T1194	1885-1895	VBG	denotes	indicating
T1195	1896-1904	VBN	denotes	targeted
T1196	1905-1914	NN	denotes	insertion
T1197	1915-1917	IN	denotes	of
T1198	1918-1921	DT	denotes	the
T1199	1922-1928	NN	denotes	vector
T1200	1929-1931	IN	denotes	at
T1201	1932-1935	DT	denotes	the
T1202	1942-1947	NN	denotes	locus
T1203	1936-1941	NN	denotes	Acadm
T1204	1948-1949	-LRB-	denotes	(
T1205	1949-1955	NN	denotes	Figure
T1206	1956-1958	CD	denotes	1B
T1207	1958-1959	-RRB-	denotes	)
T1208	1959-1960	.	denotes	.
T1209	1960-2074	sentence	denotes	Correctly targeted ES cell clones were microinjected into B6 (C57BL/6NTac) blastocysts to generate chimeric mice.
T1210	1961-1970	RB	denotes	Correctly
T1211	1971-1979	VBN	denotes	targeted
T1212	1988-1994	NNS	denotes	clones
T1213	1980-1982	NN	denotes	ES
T1214	1983-1987	NN	denotes	cell
T1215	2000-2013	VBN	denotes	microinjected
T1216	1995-1999	VBD	denotes	were
T1217	2014-2018	IN	denotes	into
T1218	2019-2021	NN	denotes	B6
T1219	2036-2047	NNS	denotes	blastocysts
T1220	2022-2023	-LRB-	denotes	(
T1221	2023-2028	NN	denotes	C57BL
T1222	2029-2034	NN	denotes	6NTac
T1223	2028-2029	HYPH	denotes	/
T1224	2034-2035	-RRB-	denotes	)
T1225	2048-2050	TO	denotes	to
T1226	2051-2059	VB	denotes	generate
T1227	2060-2068	JJ	denotes	chimeric
T1228	2069-2073	NNS	denotes	mice
T1229	2073-2074	.	denotes	.
T1230	2074-2215	sentence	denotes	Chimeric mice were backcrossed to both 129P2 and B6 inbred mice to produce MCAD+/− and eventually MCAD−/− mice on a B6/129 mixed background.
T1231	2075-2083	JJ	denotes	Chimeric
T1232	2084-2088	NNS	denotes	mice
T1233	2094-2105	VBN	denotes	backcrossed
T1234	2089-2093	VBD	denotes	were
T1235	2106-2108	IN	denotes	to
T1236	2109-2113	CC	denotes	both
T1237	2114-2119	NN	denotes	129P2
T1238	2127-2133	VBN	denotes	inbred
T1239	2120-2123	CC	denotes	and
T1240	2124-2126	NN	denotes	B6
T1241	2134-2138	NNS	denotes	mice
T1242	2139-2141	TO	denotes	to
T1243	2142-2149	VB	denotes	produce
T1244	2150-2154	NN	denotes	MCAD
T1245	2181-2185	NNS	denotes	mice
T1246	2154-2155	SYM	denotes	+
T1247	2155-2156	HYPH	denotes	/
T1248	2156-2157	SYM	denotes	−
T1249	2158-2161	CC	denotes	and
T1250	2162-2172	RB	denotes	eventually
T1251	2173-2177	NN	denotes	MCAD
T1252	2177-2178	SYM	denotes	−
T1253	2178-2179	HYPH	denotes	/
T1254	2179-2180	SYM	denotes	−
T1255	2186-2188	IN	denotes	on
T1256	2189-2190	DT	denotes	a
T1257	2204-2214	NN	denotes	background
T1258	2191-2193	NN	denotes	B6
T1259	2193-2194	HYPH	denotes	/
T1260	2194-2197	CD	denotes	129
T1261	2198-2203	JJ	denotes	mixed
T1262	2214-2215	.	denotes	.
T1263	2215-2407	sentence	denotes	The studies described here were conducted exclusively on the B6/129 mixed background compared with littermate controls or B6/129 control groups maintained by intercrosses as were the mutants.
T1264	2216-2219	DT	denotes	The
T1265	2220-2227	NNS	denotes	studies
T1266	2248-2257	VBN	denotes	conducted
T1267	2228-2237	VBN	denotes	described
T1268	2238-2242	RB	denotes	here
T1269	2243-2247	VBD	denotes	were
T1270	2258-2269	RB	denotes	exclusively
T1271	2270-2272	IN	denotes	on
T1272	2273-2276	DT	denotes	the
T1273	2290-2300	NN	denotes	background
T1274	2277-2279	NN	denotes	B6
T1275	2279-2280	HYPH	denotes	/
T1276	2280-2283	CD	denotes	129
T1277	2284-2289	JJ	denotes	mixed
T1278	2301-2309	VBN	denotes	compared
T1279	2310-2314	IN	denotes	with
T1280	2315-2325	NN	denotes	littermate
T1281	2326-2334	NNS	denotes	controls
T1282	2335-2337	CC	denotes	or
T1283	2338-2340	NN	denotes	B6
T1284	2353-2359	NNS	denotes	groups
T1285	2340-2341	HYPH	denotes	/
T1286	2341-2344	CD	denotes	129
T1287	2345-2352	NN	denotes	control
T1288	2360-2370	VBN	denotes	maintained
T1289	2371-2373	IN	denotes	by
T1290	2374-2386	NNS	denotes	intercrosses
T1291	2387-2389	IN	denotes	as
T1292	2390-2394	VBD	denotes	were
T1293	2395-2398	DT	denotes	the
T1294	2399-2406	NNS	denotes	mutants
T1295	2406-2407	.	denotes	.
T1296	2407-2504	sentence	denotes	Perpetuating this mutation as a congenic mutant line on the 129P2 background proved impractical.
T1297	2408-2420	VBG	denotes	Perpetuating
T1298	2485-2491	VBD	denotes	proved
T1299	2421-2425	DT	denotes	this
T1300	2426-2434	NN	denotes	mutation
T1301	2435-2437	IN	denotes	as
T1302	2438-2439	DT	denotes	a
T1303	2456-2460	NN	denotes	line
T1304	2440-2448	JJ	denotes	congenic
T1305	2449-2455	NN	denotes	mutant
T1306	2461-2463	IN	denotes	on
T1307	2464-2467	DT	denotes	the
T1308	2474-2484	NN	denotes	background
T1309	2468-2473	NN	denotes	129P2
T1310	2492-2503	JJ	denotes	impractical
T1311	2503-2504	.	denotes	.
T1312	2504-2672	sentence	denotes	The 129P2 mice were poor breeders as wild-types, and when introduced, the Acadm mutation was nearly lost on this background because of the high rate of neonatal death.
T1313	2505-2508	DT	denotes	The
T1314	2515-2519	NNS	denotes	mice
T1315	2509-2514	NN	denotes	129P2
T1316	2520-2524	VBD	denotes	were
T1317	2525-2529	JJ	denotes	poor
T1318	2530-2538	NNS	denotes	breeders
T1319	2539-2541	IN	denotes	as
T1320	2542-2546	JJ	denotes	wild
T1321	2547-2552	NNS	denotes	types
T1322	2546-2547	HYPH	denotes	-
T1323	2552-2554	,	denotes	,
T1324	2554-2557	CC	denotes	and
T1325	2558-2562	WRB	denotes	when
T1326	2563-2573	VBN	denotes	introduced
T1327	2605-2609	VBN	denotes	lost
T1328	2573-2575	,	denotes	,
T1329	2575-2578	DT	denotes	the
T1330	2585-2593	NN	denotes	mutation
T1331	2579-2584	NN	denotes	Acadm
T1332	2594-2597	VBD	denotes	was
T1333	2598-2604	RB	denotes	nearly
T1334	2610-2612	IN	denotes	on
T1335	2613-2617	DT	denotes	this
T1336	2618-2628	NN	denotes	background
T1337	2629-2636	IN	denotes	because
T1338	2637-2639	IN	denotes	of
T1339	2640-2643	DT	denotes	the
T1340	2649-2653	NN	denotes	rate
T1341	2644-2648	JJ	denotes	high
T1342	2654-2656	IN	denotes	of
T1343	2657-2665	JJ	denotes	neonatal
T1344	2666-2671	NN	denotes	death
T1345	2671-2672	.	denotes	.
T1346	2672-2808	sentence	denotes	Because of the molecular structure of the targeted allele, it proved virtually impossible to distinguish all three potential genotypes.
T1347	2673-2680	IN	denotes	Because
T1348	2735-2741	VBD	denotes	proved
T1349	2681-2683	IN	denotes	of
T1350	2684-2687	DT	denotes	the
T1351	2698-2707	NN	denotes	structure
T1352	2688-2697	JJ	denotes	molecular
T1353	2708-2710	IN	denotes	of
T1354	2711-2714	DT	denotes	the
T1355	2724-2730	NN	denotes	allele
T1356	2715-2723	VBN	denotes	targeted
T1357	2730-2732	,	denotes	,
T1358	2732-2734	PRP	denotes	it
T1359	2742-2751	RB	denotes	virtually
T1360	2752-2762	JJ	denotes	impossible
T1361	2763-2765	TO	denotes	to
T1362	2766-2777	VB	denotes	distinguish
T1363	2778-2781	DT	denotes	all
T1364	2798-2807	NNS	denotes	genotypes
T1365	2782-2787	CD	denotes	three
T1366	2788-2797	JJ	denotes	potential
T1367	2807-2808	.	denotes	.
T1368	2808-3003	sentence	denotes	We could clearly detect the presence or absence of the targeted allele, however, whether a particular mouse was MCAD−/− or MCAD+/− could not be determined by Southern blot or PCR of genomic DNA.
T1369	2809-2811	PRP	denotes	We
T1370	2826-2832	VB	denotes	detect
T1371	2812-2817	MD	denotes	could
T1372	2818-2825	RB	denotes	clearly
T1373	2953-2963	VBN	denotes	determined
T1374	2833-2836	DT	denotes	the
T1375	2837-2845	NN	denotes	presence
T1376	2846-2848	CC	denotes	or
T1377	2849-2856	NN	denotes	absence
T1378	2857-2859	IN	denotes	of
T1379	2860-2863	DT	denotes	the
T1380	2873-2879	NN	denotes	allele
T1381	2864-2872	VBN	denotes	targeted
T1382	2879-2881	,	denotes	,
T1383	2881-2888	RB	denotes	however
T1384	2888-2890	,	denotes	,
T1385	2890-2897	IN	denotes	whether
T1386	2917-2920	VBD	denotes	was
T1387	2898-2899	DT	denotes	a
T1388	2911-2916	NN	denotes	mouse
T1389	2900-2910	JJ	denotes	particular
T1390	2921-2925	NN	denotes	MCAD
T1391	2925-2926	SYM	denotes	−
T1392	2926-2927	HYPH	denotes	/
T1393	2927-2928	SYM	denotes	−
T1394	2929-2931	CC	denotes	or
T1395	2932-2936	NN	denotes	MCAD
T1396	2936-2937	SYM	denotes	+
T1397	2937-2938	HYPH	denotes	/
T1398	2938-2939	SYM	denotes	−
T1399	2940-2945	MD	denotes	could
T1400	2946-2949	RB	denotes	not
T1401	2950-2952	VB	denotes	be
T1402	2964-2966	IN	denotes	by
T1403	2967-2975	NNP	denotes	Southern
T1404	2976-2980	NN	denotes	blot
T1405	2981-2983	CC	denotes	or
T1406	2984-2987	NN	denotes	PCR
T1407	2988-2990	IN	denotes	of
T1408	2991-2998	JJ	denotes	genomic
T1409	2999-3002	NN	denotes	DNA
T1410	3002-3003	.	denotes	.
T1411	3003-3157	sentence	denotes	Ultimately MCAD−/− mice were ascertained by immunoblot analysis of offspring with subsequent perpetuation of MCAD−/− and MCAD+/+ mice as separate groups.
T1412	3004-3014	RB	denotes	Ultimately
T1413	3033-3044	VBN	denotes	ascertained
T1414	3015-3019	NN	denotes	MCAD
T1415	3023-3027	NNS	denotes	mice
T1416	3019-3020	SYM	denotes	−
T1417	3020-3021	HYPH	denotes	/
T1418	3021-3022	SYM	denotes	−
T1419	3028-3032	VBD	denotes	were
T1420	3045-3047	IN	denotes	by
T1421	3048-3058	NN	denotes	immunoblot
T1422	3059-3067	NN	denotes	analysis
T1423	3068-3070	IN	denotes	of
T1424	3071-3080	NN	denotes	offspring
T1425	3081-3085	IN	denotes	with
T1426	3086-3096	JJ	denotes	subsequent
T1427	3097-3109	NN	denotes	perpetuation
T1428	3110-3112	IN	denotes	of
T1429	3113-3117	NN	denotes	MCAD
T1430	3133-3137	NNS	denotes	mice
T1431	3117-3118	SYM	denotes	−
T1432	3118-3119	HYPH	denotes	/
T1433	3119-3120	SYM	denotes	−
T1434	3121-3124	CC	denotes	and
T1435	3125-3129	NN	denotes	MCAD
T1436	3129-3130	SYM	denotes	+
T1437	3130-3131	HYPH	denotes	/
T1438	3131-3132	SYM	denotes	+
T1439	3138-3140	IN	denotes	as
T1440	3141-3149	JJ	denotes	separate
T1441	3150-3156	NNS	denotes	groups
T1442	3156-3157	.	denotes	.
T1606	3159-3162	NN	denotes	RNA
T1607	3163-3171	NN	denotes	Analysis
T1608	3171-3367	sentence	denotes	RT-PCR amplification from exon 7 to 11 from total heart RNA amplified the expected 600-base pair (bp) fragment in MCAD+/+ and MCAD+/− mice, and a 1.5-kb fragment in MCAD−/− mice (data not shown).
T1609	3172-3174	NN	denotes	RT
T1610	3175-3178	NN	denotes	PCR
T1611	3174-3175	HYPH	denotes	-
T1612	3179-3192	NN	denotes	amplification
T1613	3232-3241	VBD	denotes	amplified
T1614	3193-3197	IN	denotes	from
T1615	3198-3202	NN	denotes	exon
T1616	3203-3204	CD	denotes	7
T1617	3205-3207	IN	denotes	to
T1618	3208-3210	CD	denotes	11
T1619	3211-3215	IN	denotes	from
T1620	3216-3221	JJ	denotes	total
T1621	3228-3231	NN	denotes	RNA
T1622	3222-3227	NN	denotes	heart
T1623	3242-3245	DT	denotes	the
T1624	3274-3282	NN	denotes	fragment
T1625	3246-3254	VBN	denotes	expected
T1626	3255-3258	CD	denotes	600
T1627	3264-3268	NN	denotes	pair
T1628	3258-3259	HYPH	denotes	-
T1629	3259-3263	NN	denotes	base
T1630	3269-3270	-LRB-	denotes	(
T1631	3270-3272	NN	denotes	bp
T1632	3272-3273	-RRB-	denotes	)
T1633	3283-3285	IN	denotes	in
T1634	3286-3290	NN	denotes	MCAD
T1635	3306-3310	NNS	denotes	mice
T1636	3290-3291	SYM	denotes	+
T1637	3291-3292	HYPH	denotes	/
T1638	3292-3293	SYM	denotes	+
T1639	3294-3297	CC	denotes	and
T1640	3298-3302	NN	denotes	MCAD
T1641	3302-3303	SYM	denotes	+
T1642	3303-3304	HYPH	denotes	/
T1643	3304-3305	SYM	denotes	−
T1644	3310-3312	,	denotes	,
T1645	3312-3315	CC	denotes	and
T1646	3316-3317	DT	denotes	a
T1647	3325-3333	NN	denotes	fragment
T1648	3318-3321	CD	denotes	1.5
T1649	3322-3324	NN	denotes	kb
T1650	3321-3322	HYPH	denotes	-
T1651	3334-3336	IN	denotes	in
T1652	3337-3341	NN	denotes	MCAD
T1653	3345-3349	NNS	denotes	mice
T1654	3341-3342	SYM	denotes	−
T1655	3342-3343	HYPH	denotes	/
T1656	3343-3344	SYM	denotes	−
T1657	3350-3351	-LRB-	denotes	(
T1658	3360-3365	VBN	denotes	shown
T1659	3351-3355	NNS	denotes	data
T1660	3356-3359	RB	denotes	not
T1661	3365-3366	-RRB-	denotes	)
T1662	3366-3367	.	denotes	.
T1663	3367-3537	sentence	denotes	Sequence analysis of the 1.5-kb fragment revealed that the amplified fragment consisted of exon 7 to exon 10 with 280 bp of pGEM plasmid sequence followed by exons 8–11.
T1664	3368-3376	NN	denotes	Sequence
T1665	3377-3385	NN	denotes	analysis
T1666	3409-3417	VBD	denotes	revealed
T1667	3386-3388	IN	denotes	of
T1668	3389-3392	DT	denotes	the
T1669	3400-3408	NN	denotes	fragment
T1670	3393-3396	CD	denotes	1.5
T1671	3397-3399	NN	denotes	kb
T1672	3396-3397	HYPH	denotes	-
T1673	3418-3422	IN	denotes	that
T1674	3446-3455	VBD	denotes	consisted
T1675	3423-3426	DT	denotes	the
T1676	3437-3445	NN	denotes	fragment
T1677	3427-3436	VBN	denotes	amplified
T1678	3456-3458	IN	denotes	of
T1679	3459-3463	NN	denotes	exon
T1680	3464-3465	CD	denotes	7
T1681	3466-3468	IN	denotes	to
T1682	3469-3473	NN	denotes	exon
T1683	3474-3476	CD	denotes	10
T1684	3477-3481	IN	denotes	with
T1685	3482-3485	CD	denotes	280
T1686	3486-3488	NN	denotes	bp
T1687	3489-3491	IN	denotes	of
T1688	3492-3496	NN	denotes	pGEM
T1689	3505-3513	NN	denotes	sequence
T1690	3497-3504	NN	denotes	plasmid
T1691	3514-3522	VBN	denotes	followed
T1692	3523-3525	IN	denotes	by
T1693	3526-3531	NNS	denotes	exons
T1694	3532-3533	CD	denotes	8
T1695	3533-3534	SYM	denotes	–
T1696	3534-3536	CD	denotes	11
T1697	3536-3537	.	denotes	.
T1698	3537-3640	sentence	denotes	Some of the plasmid sequences, along with the pPGKNEOpA sequence, were deleted from this spliced mRNA.
T1699	3538-3542	DT	denotes	Some
T1700	3609-3616	VBN	denotes	deleted
T1701	3543-3545	IN	denotes	of
T1702	3546-3549	DT	denotes	the
T1703	3558-3567	NNS	denotes	sequences
T1704	3550-3557	NN	denotes	plasmid
T1705	3567-3569	,	denotes	,
T1706	3569-3574	IN	denotes	along
T1707	3575-3579	IN	denotes	with
T1708	3580-3583	DT	denotes	the
T1709	3594-3602	NN	denotes	sequence
T1710	3584-3593	NN	denotes	pPGKNEOpA
T1711	3602-3604	,	denotes	,
T1712	3604-3608	VBD	denotes	were
T1713	3617-3621	IN	denotes	from
T1714	3622-3626	DT	denotes	this
T1715	3635-3639	NN	denotes	mRNA
T1716	3627-3634	VBN	denotes	spliced
T1717	3639-3640	.	denotes	.
T1718	3640-3913	sentence	denotes	Northern blot analysis revealed Acadm was normally expressed in all tissues analyzed from MCAD+/+ mice with the most robust expression occurring in brown fat, kidney, heart, skeletal muscle, and liver with minimal expression in the brain, white fat, and testes (Figure 2).
T1719	3641-3649	NNP	denotes	Northern
T1720	3650-3654	NN	denotes	blot
T1721	3655-3663	NN	denotes	analysis
T1722	3664-3672	VBD	denotes	revealed
T1723	3673-3678	NN	denotes	Acadm
T1724	3692-3701	VBN	denotes	expressed
T1725	3679-3682	VBD	denotes	was
T1726	3683-3691	RB	denotes	normally
T1727	3702-3704	IN	denotes	in
T1728	3705-3708	DT	denotes	all
T1729	3709-3716	NNS	denotes	tissues
T1730	3717-3725	VBN	denotes	analyzed
T1731	3726-3730	IN	denotes	from
T1732	3731-3735	NN	denotes	MCAD
T1733	3739-3743	NNS	denotes	mice
T1734	3735-3736	SYM	denotes	+
T1735	3736-3737	HYPH	denotes	/
T1736	3737-3738	SYM	denotes	+
T1737	3744-3748	IN	denotes	with
T1738	3749-3752	DT	denotes	the
T1739	3765-3775	NN	denotes	expression
T1740	3753-3757	RBS	denotes	most
T1741	3758-3764	JJ	denotes	robust
T1742	3776-3785	VBG	denotes	occurring
T1743	3786-3788	IN	denotes	in
T1744	3789-3794	JJ	denotes	brown
T1745	3795-3798	NN	denotes	fat
T1746	3798-3800	,	denotes	,
T1747	3800-3806	NN	denotes	kidney
T1748	3806-3808	,	denotes	,
T1749	3808-3813	NN	denotes	heart
T1750	3813-3815	,	denotes	,
T1751	3815-3823	JJ	denotes	skeletal
T1752	3824-3830	NN	denotes	muscle
T1753	3830-3832	,	denotes	,
T1754	3832-3835	CC	denotes	and
T1755	3836-3841	NN	denotes	liver
T1756	3842-3846	IN	denotes	with
T1757	3847-3854	JJ	denotes	minimal
T1758	3855-3865	NN	denotes	expression
T1759	3866-3868	IN	denotes	in
T1760	3869-3872	DT	denotes	the
T1761	3873-3878	NN	denotes	brain
T1762	3878-3880	,	denotes	,
T1763	3880-3885	JJ	denotes	white
T1764	3886-3889	NN	denotes	fat
T1765	3889-3891	,	denotes	,
T1766	3891-3894	CC	denotes	and
T1767	3895-3901	NNS	denotes	testes
T1768	3902-3903	-LRB-	denotes	(
T1769	3903-3909	NN	denotes	Figure
T1770	3910-3911	CD	denotes	2
T1771	3911-3912	-RRB-	denotes	)
T1772	3912-3913	.	denotes	.
T1773	3913-4075	sentence	denotes	Interestingly, although RT-PCR amplified an incorrectly spliced Acadm transcript, no Acadm transcripts were detected by northern blot analysis from MCAD−/− mice.
T1774	3914-3927	RB	denotes	Interestingly
T1775	4022-4030	VBN	denotes	detected
T1776	3927-3929	,	denotes	,
T1777	3929-3937	IN	denotes	although
T1778	3945-3954	VBD	denotes	amplified
T1779	3938-3940	NN	denotes	RT
T1780	3941-3944	NN	denotes	PCR
T1781	3940-3941	HYPH	denotes	-
T1782	3955-3957	DT	denotes	an
T1783	3984-3994	NN	denotes	transcript
T1784	3958-3969	RB	denotes	incorrectly
T1785	3970-3977	VBN	denotes	spliced
T1786	3978-3983	NN	denotes	Acadm
T1787	3994-3996	,	denotes	,
T1788	3996-3998	DT	denotes	no
T1789	4005-4016	NNS	denotes	transcripts
T1790	3999-4004	NN	denotes	Acadm
T1791	4017-4021	VBD	denotes	were
T1792	4031-4033	IN	denotes	by
T1793	4034-4042	NNP	denotes	northern
T1794	4043-4047	NN	denotes	blot
T1795	4048-4056	NN	denotes	analysis
T1796	4057-4061	IN	denotes	from
T1797	4062-4066	NN	denotes	MCAD
T1798	4070-4074	NNS	denotes	mice
T1799	4066-4067	SYM	denotes	−
T1800	4067-4068	HYPH	denotes	/
T1801	4068-4069	SYM	denotes	−
T1802	4074-4075	.	denotes	.
T1803	4075-4217	sentence	denotes	These results strongly suggest that the mutant RNA is unstable and degraded rapidly or, alternatively, undergoes nonsense mediated RNA decay.
T1804	4076-4081	DT	denotes	These
T1805	4082-4089	NNS	denotes	results
T1806	4099-4106	VBP	denotes	suggest
T1807	4090-4098	RB	denotes	strongly
T1808	4107-4111	IN	denotes	that
T1809	4127-4129	VBZ	denotes	is
T1810	4112-4115	DT	denotes	the
T1811	4123-4126	NN	denotes	RNA
T1812	4116-4122	NN	denotes	mutant
T1813	4130-4138	JJ	denotes	unstable
T1814	4139-4142	CC	denotes	and
T1815	4143-4151	VBN	denotes	degraded
T1816	4152-4159	RB	denotes	rapidly
T1817	4160-4162	CC	denotes	or
T1818	4162-4164	,	denotes	,
T1819	4164-4177	RB	denotes	alternatively
T1820	4179-4188	VBZ	denotes	undergoes
T1821	4177-4179	,	denotes	,
T1822	4189-4197	NN	denotes	nonsense
T1823	4198-4206	VBN	denotes	mediated
T1824	4211-4216	NN	denotes	decay
T1825	4207-4210	NN	denotes	RNA
T1826	4216-4217	.	denotes	.
T1979	4596-4601	NN	denotes	Liver
T1980	4602-4608	NN	denotes	Enzyme
T1981	4609-4617	NNS	denotes	Analyses
T1982	4617-4789	sentence	denotes	Immunoblot analyses of liver homogenates with anti-MCAD antisera demonstrated that the 42 kDa MCAD monomer was present in MCAD+/+ mice, but not in MCAD−/− mice (Figure 3).
T1983	4618-4628	NN	denotes	Immunoblot
T1984	4629-4637	NNS	denotes	analyses
T1985	4683-4695	VBD	denotes	demonstrated
T1986	4638-4640	IN	denotes	of
T1987	4641-4646	NN	denotes	liver
T1988	4647-4658	NNS	denotes	homogenates
T1989	4659-4663	IN	denotes	with
T1990	4664-4673	JJ	denotes	anti-MCAD
T1991	4674-4682	NNS	denotes	antisera
T1992	4696-4700	IN	denotes	that
T1993	4725-4728	VBD	denotes	was
T1994	4701-4704	DT	denotes	the
T1995	4717-4724	NN	denotes	monomer
T1996	4705-4707	CD	denotes	42
T1997	4708-4711	NN	denotes	kDa
T1998	4712-4716	NN	denotes	MCAD
T1999	4729-4736	JJ	denotes	present
T2000	4737-4739	IN	denotes	in
T2001	4740-4744	NN	denotes	MCAD
T2002	4748-4752	NNS	denotes	mice
T2003	4744-4745	SYM	denotes	+
T2004	4745-4746	HYPH	denotes	/
T2005	4746-4747	SYM	denotes	+
T2006	4752-4754	,	denotes	,
T2007	4754-4757	CC	denotes	but
T2008	4758-4761	RB	denotes	not
T2009	4762-4764	IN	denotes	in
T2010	4765-4769	NN	denotes	MCAD
T2011	4773-4777	NNS	denotes	mice
T2012	4769-4770	SYM	denotes	−
T2013	4770-4771	HYPH	denotes	/
T2014	4771-4772	SYM	denotes	−
T2015	4778-4779	-LRB-	denotes	(
T2016	4779-4785	NN	denotes	Figure
T2017	4786-4787	CD	denotes	3
T2018	4787-4788	-RRB-	denotes	)
T2019	4788-4789	.	denotes	.
T2020	4789-4977	sentence	denotes	As a control analysis, anti–short-chain acyl-CoA dehydrogenase (SCAD) antisera revealed no differences in levels of expression of SCAD protein between MCAD+/+ and MCAD−/− mice (Figure 3).
T2021	4790-4792	IN	denotes	As
T2022	4869-4877	VBD	denotes	revealed
T2023	4793-4794	DT	denotes	a
T2024	4803-4811	NN	denotes	analysis
T2025	4795-4802	NN	denotes	control
T2026	4811-4813	,	denotes	,
T2027	4813-4823	JJ	denotes	anti–short
T2028	4824-4829	NN	denotes	chain
T2029	4823-4824	HYPH	denotes	-
T2030	4839-4852	NN	denotes	dehydrogenase
T2031	4830-4834	NN	denotes	acyl
T2032	4835-4838	NN	denotes	CoA
T2033	4834-4835	HYPH	denotes	-
T2034	4854-4858	NN	denotes	SCAD
T2035	4853-4854	-LRB-	denotes	(
T2036	4860-4868	NNS	denotes	antisera
T2037	4858-4859	-RRB-	denotes	)
T2038	4878-4880	DT	denotes	no
T2039	4881-4892	NNS	denotes	differences
T2040	4893-4895	IN	denotes	in
T2041	4896-4902	NNS	denotes	levels
T2042	4903-4905	IN	denotes	of
T2043	4906-4916	NN	denotes	expression
T2044	4917-4919	IN	denotes	of
T2045	4920-4924	NN	denotes	SCAD
T2046	4925-4932	NN	denotes	protein
T2047	4933-4940	IN	denotes	between
T2048	4941-4945	NN	denotes	MCAD
T2049	4961-4965	NNS	denotes	mice
T2050	4945-4946	SYM	denotes	+
T2051	4946-4947	HYPH	denotes	/
T2052	4947-4948	SYM	denotes	+
T2053	4949-4952	CC	denotes	and
T2054	4953-4957	NN	denotes	MCAD
T2055	4957-4958	SYM	denotes	−
T2056	4958-4959	HYPH	denotes	/
T2057	4959-4960	SYM	denotes	−
T2058	4966-4967	-LRB-	denotes	(
T2059	4967-4973	NN	denotes	Figure
T2060	4974-4975	CD	denotes	3
T2061	4975-4976	-RRB-	denotes	)
T2062	4976-4977	.	denotes	.
T2063	4977-5703	sentence	denotes	Figure 3 Immunoblots of Liver Homogenates from MCAD+/+ and MCAD−/− Mice These were probed with anti-MCAD antibody or anti-SCAD antibody. Homozygous MCAD−/− mice had no detectable MCAD protein. MCAD protein is only detectable under the MCAD protein–spiked (positive control) lane. As a control analysis, liver homogenates probed with anti-SCAD antibody revealed that SCAD protein was present in both MCAD+/+ and MCAD−/− mice. No MCAD positive-control protein is detected by anti-SCAD antibodies (MCAD lane). mw, molecular weight standards. Enzyme activity was analyzed in mouse liver homogenates using the electron transport flavoprotein (ETF) reduction assay with octanoyl-CoA (C8:0) and palmitoyl-CoA (C16:0) as substrates.
T2064	5518-5524	NN	denotes	Enzyme
T2065	5525-5533	NN	denotes	activity
T2066	5538-5546	VBN	denotes	analyzed
T2067	5534-5537	VBD	denotes	was
T2068	5547-5549	IN	denotes	in
T2069	5550-5555	NN	denotes	mouse
T2070	5562-5573	NNS	denotes	homogenates
T2071	5556-5561	NN	denotes	liver
T2072	5574-5579	VBG	denotes	using
T2073	5580-5583	DT	denotes	the
T2074	5632-5637	NN	denotes	assay
T2075	5584-5592	NN	denotes	electron
T2076	5603-5615	NN	denotes	flavoprotein
T2077	5593-5602	NN	denotes	transport
T2078	5616-5617	-LRB-	denotes	(
T2079	5617-5620	NN	denotes	ETF
T2080	5620-5621	-RRB-	denotes	)
T2081	5622-5631	NN	denotes	reduction
T2082	5638-5642	IN	denotes	with
T2083	5643-5651	NN	denotes	octanoyl
T2084	5652-5655	NN	denotes	CoA
T2085	5651-5652	HYPH	denotes	-
T2086	5656-5657	-LRB-	denotes	(
T2087	5657-5659	NN	denotes	C8
T2088	5659-5660	:	denotes	:
T2089	5660-5661	CD	denotes	0
T2090	5661-5662	-RRB-	denotes	)
T2091	5663-5666	CC	denotes	and
T2092	5667-5676	NN	denotes	palmitoyl
T2093	5677-5680	NN	denotes	CoA
T2094	5676-5677	HYPH	denotes	-
T2095	5681-5682	-LRB-	denotes	(
T2096	5682-5685	NN	denotes	C16
T2097	5685-5686	:	denotes	:
T2098	5686-5687	CD	denotes	0
T2099	5687-5688	-RRB-	denotes	)
T2100	5689-5691	IN	denotes	as
T2101	5692-5702	NNS	denotes	substrates
T2102	5702-5703	.	denotes	.
T2103	5703-5877	sentence	denotes	MCAD−/− mice had a significant reduction in ability to dehydrogenate octanoyl-CoA and a modest reduction in activity toward palmitoyl-CoA compared to MCAD+/+ mice (Table 1).
T2104	5704-5708	NN	denotes	MCAD
T2105	5712-5716	NNS	denotes	mice
T2106	5708-5709	SYM	denotes	−
T2107	5709-5710	HYPH	denotes	/
T2108	5710-5711	SYM	denotes	−
T2109	5717-5720	VBD	denotes	had
T2110	5721-5722	DT	denotes	a
T2111	5735-5744	NN	denotes	reduction
T2112	5723-5734	JJ	denotes	significant
T2113	5745-5747	IN	denotes	in
T2114	5748-5755	NN	denotes	ability
T2115	5756-5758	TO	denotes	to
T2116	5759-5772	VB	denotes	dehydrogenate
T2117	5773-5781	NN	denotes	octanoyl
T2118	5782-5785	NN	denotes	CoA
T2119	5781-5782	HYPH	denotes	-
T2120	5786-5789	CC	denotes	and
T2121	5790-5791	DT	denotes	a
T2122	5799-5808	NN	denotes	reduction
T2123	5792-5798	JJ	denotes	modest
T2124	5809-5811	IN	denotes	in
T2125	5812-5820	NN	denotes	activity
T2126	5821-5827	IN	denotes	toward
T2127	5828-5837	NN	denotes	palmitoyl
T2128	5838-5841	NN	denotes	CoA
T2129	5837-5838	HYPH	denotes	-
T2130	5842-5850	VBN	denotes	compared
T2131	5851-5853	IN	denotes	to
T2132	5854-5858	NN	denotes	MCAD
T2133	5862-5866	NNS	denotes	mice
T2134	5858-5859	SYM	denotes	+
T2135	5859-5860	HYPH	denotes	/
T2136	5860-5861	SYM	denotes	+
T2137	5867-5868	-LRB-	denotes	(
T2138	5868-5873	NN	denotes	Table
T2139	5874-5875	CD	denotes	1
T2140	5875-5876	-RRB-	denotes	)
T2141	5876-5877	.	denotes	.
T2142	5877-6051	sentence	denotes	Specifically, the dehydrogenation of octanoyl-CoA and palmitoyl-CoA substrates were reduced by 75% and by 30%, respectively, in MCAD−/− mice as compared to MCAD+/+ controls.
T2143	5878-5890	RB	denotes	Specifically
T2144	5962-5969	VBN	denotes	reduced
T2145	5890-5892	,	denotes	,
T2146	5892-5895	DT	denotes	the
T2147	5896-5911	NN	denotes	dehydrogenation
T2148	5912-5914	IN	denotes	of
T2149	5915-5923	NN	denotes	octanoyl
T2150	5924-5927	NN	denotes	CoA
T2151	5923-5924	HYPH	denotes	-
T2152	5946-5956	NNS	denotes	substrates
T2153	5928-5931	CC	denotes	and
T2155	5942-5945	NN	denotes	CoA
T2156	5941-5942	HYPH	denotes	-
T2157	5957-5961	VBD	denotes	were
T2158	5970-5972	IN	denotes	by
T2159	5973-5975	CD	denotes	75
T2160	5975-5976	NN	denotes	%
T2161	5977-5980	CC	denotes	and
T2162	5981-5983	IN	denotes	by
T2163	5984-5986	CD	denotes	30
T2164	5986-5987	NN	denotes	%
T2165	5987-5989	,	denotes	,
T2437	6949-6950	SYM	denotes	+
T7247	907-915	NN	denotes	Strategy
T7248	916-919	IN	denotes	for
T7249	920-930	NN	denotes	Disruption
T7250	931-933	IN	denotes	of
T7251	934-937	DT	denotes	the
T7252	950-954	NN	denotes	Gene
T7253	938-943	NN	denotes	Mouse
T7254	944-949	NN	denotes	Acadm
T7255	954-1072	sentence	denotes	(A) The MCAD IV2 insertion targeting vector with a deleted 1.3-kb region encompassing exon 10 and flanking sequences.
T7256	955-956	-LRB-	denotes	(
T7257	956-957	LS	denotes	A
T7258	992-998	NN	denotes	vector
T7259	957-958	-RRB-	denotes	)
T7260	959-962	DT	denotes	The
T7261	963-967	NN	denotes	MCAD
T7262	972-981	NN	denotes	insertion
T7263	968-971	NN	denotes	IV2
T7264	982-991	NN	denotes	targeting
T7265	999-1003	IN	denotes	with
T7266	1004-1005	DT	denotes	a
T7267	1021-1027	NN	denotes	region
T7268	1006-1013	VBN	denotes	deleted
T7269	1014-1017	CD	denotes	1.3
T7270	1018-1020	NN	denotes	kb
T7271	1017-1018	HYPH	denotes	-
T7272	1028-1040	VBG	denotes	encompassing
T7273	1041-1045	NN	denotes	exon
T7274	1046-1048	CD	denotes	10
T7275	1049-1052	CC	denotes	and
T7276	1053-1061	VBG	denotes	flanking
T7277	1062-1071	NNS	denotes	sequences
T7278	1071-1072	.	denotes	.
T7279	1072-1236	sentence	denotes	MCAD IV2 undergoes gap repair upon homologous recombination at the endogenous Acadm locus resulting in a duplication of exons 8, 9, and 10 at the disrupted allele.
T7280	1073-1077	NN	denotes	MCAD
T7281	1078-1081	NN	denotes	IV2
T7282	1082-1091	VBZ	denotes	undergoes
T7283	1092-1095	NN	denotes	gap
T7284	1096-1102	NN	denotes	repair
T7285	1103-1107	IN	denotes	upon
T7286	1108-1118	JJ	denotes	homologous
T7287	1119-1132	NN	denotes	recombination
T7288	1133-1135	IN	denotes	at
T7289	1136-1139	DT	denotes	the
T7290	1157-1162	NN	denotes	locus
T7291	1140-1150	JJ	denotes	endogenous
T7292	1151-1156	NN	denotes	Acadm
T7293	1163-1172	VBG	denotes	resulting
T7294	1173-1175	IN	denotes	in
T7295	1176-1177	DT	denotes	a
T7296	1178-1189	NN	denotes	duplication
T7297	1190-1192	IN	denotes	of
T7298	1193-1198	NNS	denotes	exons
T7299	1199-1200	CD	denotes	8
T7300	1200-1202	,	denotes	,
T7301	1202-1203	CD	denotes	9
T7302	1203-1205	,	denotes	,
T7303	1205-1208	CC	denotes	and
T7304	1209-1211	CD	denotes	10
T7305	1212-1214	IN	denotes	at
T7306	1215-1218	DT	denotes	the
T7307	1229-1235	NN	denotes	allele
T7308	1219-1228	VBN	denotes	disrupted
T7309	1235-1236	.	denotes	.
T7310	1236-1324	sentence	denotes	(B) Southern blot analysis of EcoRI-digested genomic DNA from ES cells screened by PCR.
T7311	1237-1238	-LRB-	denotes	(
T7312	1238-1239	LS	denotes	B
T7313	1255-1263	NN	denotes	analysis
T7314	1239-1240	-RRB-	denotes	)
T7315	1241-1249	NNP	denotes	Southern
T7316	1250-1254	NN	denotes	blot
T7317	1264-1266	IN	denotes	of
T7318	1267-1272	NN	denotes	EcoRI
T7319	1273-1281	VBN	denotes	digested
T7320	1272-1273	HYPH	denotes	-
T7321	1290-1293	NN	denotes	DNA
T7322	1282-1289	JJ	denotes	genomic
T7323	1294-1298	IN	denotes	from
T7324	1299-1301	NN	denotes	ES
T7325	1302-1307	NNS	denotes	cells
T7326	1308-1316	VBN	denotes	screened
T7327	1317-1319	IN	denotes	by
T7328	1320-1323	NN	denotes	PCR
T7329	1323-1324	.	denotes	.
T7330	1324-1531	sentence	denotes	Probe A, a DNA fragment consisting of a portion of exon 10 that is not present in the targeting vector, hybridizes to an endogenous 3.1-kb fragment and, upon homologous recombination, to a 13.2-kb fragment.
T7331	1325-1330	NN	denotes	Probe
T7332	1331-1332	NN	denotes	A
T7333	1429-1439	VBZ	denotes	hybridizes
T7334	1332-1334	,	denotes	,
T7335	1334-1335	DT	denotes	a
T7336	1340-1348	NN	denotes	fragment
T7337	1336-1339	NN	denotes	DNA
T7338	1349-1359	VBG	denotes	consisting
T7339	1360-1362	IN	denotes	of
T7340	1363-1364	DT	denotes	a
T7341	1365-1372	NN	denotes	portion
T7342	1373-1375	IN	denotes	of
T7343	1376-1380	NN	denotes	exon
T7344	1381-1383	CD	denotes	10
T7345	1384-1388	WDT	denotes	that
T7346	1389-1391	VBZ	denotes	is
T7347	1392-1395	RB	denotes	not
T7348	1396-1403	JJ	denotes	present
T7349	1404-1406	IN	denotes	in
T7350	1407-1410	DT	denotes	the
T7351	1421-1427	NN	denotes	vector
T7352	1411-1420	NN	denotes	targeting
T7353	1427-1429	,	denotes	,
T7354	1440-1442	IN	denotes	to
T7355	1443-1445	DT	denotes	an
T7356	1464-1472	NN	denotes	fragment
T7357	1446-1456	JJ	denotes	endogenous
T7358	1457-1460	CD	denotes	3.1
T7359	1461-1463	NN	denotes	kb
T7360	1460-1461	HYPH	denotes	-
T7361	1473-1476	CC	denotes	and
T7362	1476-1478	,	denotes	,
T7363	1478-1482	IN	denotes	upon
T7364	1509-1511	IN	denotes	to
T7365	1483-1493	JJ	denotes	homologous
T7366	1494-1507	NN	denotes	recombination
T7367	1507-1509	,	denotes	,
T7368	1512-1513	DT	denotes	a
T7369	1522-1530	NN	denotes	fragment
T7370	1514-1518	CD	denotes	13.2
T7371	1519-1521	NN	denotes	kb
T7372	1518-1519	HYPH	denotes	-
T7373	1530-1531	.	denotes	.
T7374	1531-1626	sentence	denotes	Lane 1 represents a wild-type ES cell line, and Lane 2 and 3 represent targeted ES cell lines.
T7375	1532-1536	NN	denotes	Lane
T7376	1539-1549	VBZ	denotes	represents
T7377	1537-1538	CD	denotes	1
T7378	1550-1551	DT	denotes	a
T7379	1570-1574	NN	denotes	line
T7380	1552-1556	JJ	denotes	wild
T7381	1557-1561	NN	denotes	type
T7382	1556-1557	HYPH	denotes	-
T7383	1562-1564	NN	denotes	ES
T7384	1565-1569	NN	denotes	cell
T7385	1574-1576	,	denotes	,
T7386	1576-1579	CC	denotes	and
T7387	1580-1584	NN	denotes	Lane
T7388	1585-1586	CD	denotes	2
T7389	1593-1602	VBP	denotes	represent
T7390	1587-1590	CC	denotes	and
T7391	1591-1592	CD	denotes	3
T7392	1603-1611	VBN	denotes	targeted
T7393	1620-1625	NNS	denotes	lines
T7394	1612-1614	NN	denotes	ES
T7395	1615-1619	NN	denotes	cell
T7396	1625-1626	.	denotes	.
T7455	4228-4236	NNP	denotes	Northern
T7456	4237-4241	NN	denotes	Blot
T7457	4242-4250	NN	denotes	Analysis
T7458	4251-4255	IN	denotes	from
T7459	4256-4260	NN	denotes	MCAD
T7460	4292-4296	NNS	denotes	Mice
T7461	4260-4261	SYM	denotes	−
T7462	4261-4262	HYPH	denotes	/
T7463	4262-4263	SYM	denotes	−
T7464	4264-4265	-LRB-	denotes	(
T7465	4269-4270	CD	denotes	2
T7466	4265-4266	NN	denotes	n
T7467	4267-4268	SYM	denotes	=
T7468	4270-4271	-RRB-	denotes	)
T7469	4272-4275	CC	denotes	and
T7470	4276-4280	NN	denotes	MCAD
T7471	4280-4281	SYM	denotes	+
T7472	4281-4282	HYPH	denotes	/
T7473	4282-4283	SYM	denotes	+
T7474	4284-4285	-LRB-	denotes	(
T7475	4289-4290	CD	denotes	2
T7476	4285-4286	NN	denotes	n
T7477	4287-4288	SYM	denotes	=
T7478	4290-4291	-RRB-	denotes	)
T7479	4296-4448	sentence	denotes	Acadm message was detected from the heart, liver, brown fat, brain, kidney, and muscle (and white fat and testes, data not shown) of only MCAD+/+ mice.
T7480	4297-4302	NN	denotes	Acadm
T7481	4303-4310	NN	denotes	message
T7482	4315-4323	VBN	denotes	detected
T7483	4311-4314	VBD	denotes	was
T7484	4324-4328	IN	denotes	from
T7485	4329-4332	DT	denotes	the
T7486	4333-4338	NN	denotes	heart
T7487	4338-4340	,	denotes	,
T7488	4340-4345	NN	denotes	liver
T7489	4345-4347	,	denotes	,
T7490	4347-4352	JJ	denotes	brown
T7491	4353-4356	NN	denotes	fat
T7492	4356-4358	,	denotes	,
T7493	4358-4363	NN	denotes	brain
T7494	4363-4365	,	denotes	,
T7495	4365-4371	NN	denotes	kidney
T7496	4371-4373	,	denotes	,
T7497	4373-4376	CC	denotes	and
T7498	4377-4383	NN	denotes	muscle
T7499	4384-4385	-LRB-	denotes	(
T7500	4385-4388	CC	denotes	and
T7501	4389-4394	JJ	denotes	white
T7502	4395-4398	NN	denotes	fat
T7503	4399-4402	CC	denotes	and
T7504	4403-4409	NNS	denotes	testes
T7505	4409-4411	,	denotes	,
T7506	4420-4425	VBN	denotes	shown
T7507	4411-4415	NNS	denotes	data
T7508	4416-4419	RB	denotes	not
T7509	4425-4426	-RRB-	denotes	)
T7510	4427-4429	IN	denotes	of
T7511	4430-4434	JJ	denotes	only
T7512	4443-4447	NNS	denotes	mice
T7513	4435-4439	NN	denotes	MCAD
T7514	4439-4440	SYM	denotes	+
T7515	4440-4441	HYPH	denotes	/
T7516	4441-4442	SYM	denotes	+
T7517	4447-4448	.	denotes	.
T7518	4448-4530	sentence	denotes	Most robust expression occurred in brown fat, kidney, heart, and skeletal muscle.
T7519	4449-4453	RBS	denotes	Most
T7520	4461-4471	NN	denotes	expression
T7521	4454-4460	JJ	denotes	robust
T7522	4472-4480	VBD	denotes	occurred
T7523	4481-4483	IN	denotes	in
T7524	4484-4489	JJ	denotes	brown
T7525	4490-4493	NN	denotes	fat
T7526	4493-4495	,	denotes	,
T7527	4495-4501	NN	denotes	kidney
T7528	4501-4503	,	denotes	,
T7529	4503-4508	NN	denotes	heart
T7530	4508-4510	,	denotes	,
T7531	4510-4513	CC	denotes	and
T7532	4514-4522	JJ	denotes	skeletal
T7533	4523-4529	NN	denotes	muscle
T7534	4529-4530	.	denotes	.
T7535	4530-4594	sentence	denotes	MCAD−/− mice had no detectable message in all tissues examined.
T7536	4531-4535	NN	denotes	MCAD
T7537	4539-4543	NNS	denotes	mice
T7538	4535-4536	SYM	denotes	−
T7539	4536-4537	HYPH	denotes	/
T7540	4537-4538	SYM	denotes	−
T7541	4544-4547	VBD	denotes	had
T7542	4548-4550	DT	denotes	no
T7543	4562-4569	NN	denotes	message
T7544	4551-4561	JJ	denotes	detectable
T7545	4570-4572	IN	denotes	in
T7546	4573-4576	DT	denotes	all
T7547	4577-4584	NNS	denotes	tissues
T7548	4585-4593	VBN	denotes	examined
T7549	4593-4594	.	denotes	.
T7638	4988-4999	NNS	denotes	Immunoblots
T7639	5000-5002	IN	denotes	of
T7640	5003-5008	NN	denotes	Liver
T7641	5009-5020	NNS	denotes	Homogenates
T7642	5021-5025	IN	denotes	from
T7643	5026-5030	NN	denotes	MCAD
T7644	5046-5050	NNS	denotes	Mice
T7645	5030-5031	SYM	denotes	+
T7646	5031-5032	HYPH	denotes	/
T7647	5032-5033	SYM	denotes	+
T7648	5034-5037	CC	denotes	and
T7649	5038-5042	NN	denotes	MCAD
T7650	5042-5043	SYM	denotes	−
T7651	5043-5044	HYPH	denotes	/
T7652	5044-5045	SYM	denotes	−
T7653	5050-5115	sentence	denotes	These were probed with anti-MCAD antibody or anti-SCAD antibody.
T7654	5051-5056	DT	denotes	These
T7655	5062-5068	VBN	denotes	probed
T7656	5057-5061	VBD	denotes	were
T7657	5069-5073	IN	denotes	with
T7658	5074-5083	JJ	denotes	anti-MCAD
T7659	5084-5092	NN	denotes	antibody
T7660	5093-5095	CC	denotes	or
T7661	5096-5105	JJ	denotes	anti-SCAD
T7662	5106-5114	NN	denotes	antibody
T7663	5114-5115	.	denotes	.
T7664	5115-5171	sentence	denotes	Homozygous MCAD−/− mice had no detectable MCAD protein.
T7665	5116-5126	JJ	denotes	Homozygous
T7666	5135-5139	NNS	denotes	mice
T7667	5127-5131	NN	denotes	MCAD
T7668	5131-5132	SYM	denotes	−
T7669	5132-5133	HYPH	denotes	/
T7670	5133-5134	SYM	denotes	−
T7671	5140-5143	VBD	denotes	had
T7672	5144-5146	DT	denotes	no
T7673	5163-5170	NN	denotes	protein
T7674	5147-5157	JJ	denotes	detectable
T7675	5158-5162	NN	denotes	MCAD
T7676	5170-5171	.	denotes	.
T7677	5171-5258	sentence	denotes	MCAD protein is only detectable under the MCAD protein–spiked (positive control) lane.
T7678	5172-5176	NN	denotes	MCAD
T7679	5177-5184	NN	denotes	protein
T7680	5185-5187	VBZ	denotes	is
T7681	5188-5192	RB	denotes	only
T7682	5193-5203	JJ	denotes	detectable
T7683	5204-5209	IN	denotes	under
T7684	5210-5213	DT	denotes	the
T7685	5253-5257	NN	denotes	lane
T7686	5214-5218	NN	denotes	MCAD
T7687	5219-5226	NN	denotes	protein
T7688	5227-5233	VBN	denotes	spiked
T7689	5226-5227	HYPH	denotes	–
T7690	5234-5235	-LRB-	denotes	(
T7691	5244-5251	NN	denotes	control
T7692	5235-5243	JJ	denotes	positive
T7693	5251-5252	-RRB-	denotes	)
T7694	5257-5258	.	denotes	.
T7695	5258-5403	sentence	denotes	As a control analysis, liver homogenates probed with anti-SCAD antibody revealed that SCAD protein was present in both MCAD+/+ and MCAD−/− mice.
T7696	5259-5261	IN	denotes	As
T7697	5331-5339	VBD	denotes	revealed
T7698	5262-5263	DT	denotes	a
T7699	5272-5280	NN	denotes	analysis
T7700	5264-5271	NN	denotes	control
T7701	5280-5282	,	denotes	,
T7702	5282-5287	NN	denotes	liver
T7703	5288-5299	NNS	denotes	homogenates
T7704	5300-5306	VBN	denotes	probed
T7705	5307-5311	IN	denotes	with
T7706	5312-5321	JJ	denotes	anti-SCAD
T7707	5322-5330	NN	denotes	antibody
T7708	5340-5344	IN	denotes	that
T7709	5358-5361	VBD	denotes	was
T7710	5345-5349	NN	denotes	SCAD
T7711	5350-5357	NN	denotes	protein
T7712	5362-5369	JJ	denotes	present
T7713	5370-5372	IN	denotes	in
T7714	5373-5377	CC	denotes	both
T7715	5378-5382	NN	denotes	MCAD
T7716	5398-5402	NNS	denotes	mice
T7717	5382-5383	SYM	denotes	+
T7718	5383-5384	HYPH	denotes	/
T7719	5384-5385	SYM	denotes	+
T7720	5386-5389	CC	denotes	and
T7721	5390-5394	NN	denotes	MCAD
T7722	5394-5395	SYM	denotes	−
T7723	5395-5396	HYPH	denotes	/
T7724	5396-5397	SYM	denotes	−
T7725	5402-5403	.	denotes	.
T7726	5403-5485	sentence	denotes	No MCAD positive-control protein is detected by anti-SCAD antibodies (MCAD lane).
T7727	5404-5406	DT	denotes	No
T7728	5429-5436	NN	denotes	protein
T7729	5407-5411	NN	denotes	MCAD
T7730	5412-5420	JJ	denotes	positive
T7731	5421-5428	NN	denotes	control
T7732	5420-5421	HYPH	denotes	-
T7733	5440-5448	VBN	denotes	detected
T7734	5437-5439	VBZ	denotes	is
T7735	5449-5451	IN	denotes	by
T7736	5452-5461	JJ	denotes	anti-SCAD
T7737	5462-5472	NNS	denotes	antibodies
T7738	5473-5474	-LRB-	denotes	(
T7739	5479-5483	NN	denotes	lane
T7740	5474-5478	NN	denotes	MCAD
T7741	5483-5484	-RRB-	denotes	)
T7742	5484-5485	.	denotes	.
T7743	5485-5517	sentence	denotes	mw, molecular weight standards.
T7744	5486-5488	NN	denotes	mw
T7745	5488-5490	,	denotes	,
T7746	5490-5499	JJ	denotes	molecular
T7747	5507-5516	NNS	denotes	standards
T7748	5500-5506	NN	denotes	weight
T7749	5516-5517	.	denotes	.
T8117	11102-11103	.	denotes	.
T8161	6061-6076	NNS	denotes	Characteristics
T8162	6077-6079	IN	denotes	of
T8163	6080-6084	NN	denotes	MCAD
T8164	6085-6094	JJ	denotes	Deficient
T8165	6084-6085	HYPH	denotes	-
T8166	6095-6099	NNS	denotes	Mice
T8116	11096-11097	SYM	denotes	−
T8115	11095-11096	HYPH	denotes	/
T8114	11094-11095	SYM	denotes	−
T8113	11098-11102	NNS	denotes	mice
T8112	11090-11094	NN	denotes	MCAD
T8111	11087-11089	IN	denotes	in
T8110	11078-11086	NN	denotes	necrosis
T8109	11074-11077	CC	denotes	and
T8108	11053-11060	NN	denotes	myocyte
T8107	11042-11052	JJ	denotes	multifocal
T8106	11035-11041	JJ	denotes	active
T8105	11061-11073	NN	denotes	degeneration
T8104	11027-11034	JJ	denotes	chronic
T8103	11022-11026	IN	denotes	with
T8102	10999-11006	JJ	denotes	Diffuse
T8101	10997-10998	-RRB-	denotes	)
T8100	10996-10997	LS	denotes	D
T8099	10992-10995	CC	denotes	and
T8098	11007-11021	NN	denotes	cardiomyopathy
T8097	10990-10991	LS	denotes	C
T8096	10989-10990	-LRB-	denotes	(
T8095	10988-11103	sentence	denotes	(C and D) Diffuse cardiomyopathy with chronic active multifocal myocyte degeneration and necrosis in MCAD−/− mice.
T8042	10761-10762	.	denotes	.
T8041	10754-10755	HYPH	denotes	-
T8040	10755-10756	NN	denotes	h
T8039	10752-10754	CD	denotes	24
T8038	10757-10761	NN	denotes	fast
T8037	10750-10751	DT	denotes	a
T8036	10740-10749	VBG	denotes	following
T8035	10730-10739	NN	denotes	steatosis
T8034	10722-10729	JJ	denotes	hepatic
T8033	10719-10721	IN	denotes	of
T8032	10710-10718	NN	denotes	evidence
T8031	10707-10709	DT	denotes	no
T8030	10696-10697	SYM	denotes	+
T8029	10695-10696	HYPH	denotes	/
T8028	10694-10695	SYM	denotes	+
T8027	10698-10702	NNS	denotes	mice
T8026	10690-10694	NN	denotes	MCAD
T8025	10688-10689	-RRB-	denotes	)
T8024	10703-10706	VBD	denotes	had
T8023	10687-10688	LS	denotes	A
T8022	10686-10687	-LRB-	denotes	(
T8021	10685-10762	sentence	denotes	(A) MCAD+/+ mice had no evidence of hepatic steatosis following a 24-h fast.
T8020	10679-10680	SYM	denotes	−
T8019	10678-10679	HYPH	denotes	/
T8018	10677-10678	SYM	denotes	−
T8017	10673-10677	NN	denotes	MCAD
T8016	10669-10672	CC	denotes	and
T8015	10667-10668	SYM	denotes	+
T8014	10666-10667	HYPH	denotes	/
T8013	10665-10666	SYM	denotes	+
T8012	10681-10685	NNS	denotes	Mice
T8011	10661-10665	NN	denotes	MCAD
T8010	10658-10660	IN	denotes	of
T8009	10643-10657	NN	denotes	Histopathology
T7957	10065-10066	.	denotes	.
T7956	10057-10065	NN	denotes	asterisk
T7955	10054-10056	DT	denotes	an
T7954	10051-10053	IN	denotes	by
T7953	10037-10040	VBP	denotes	are
T7952	10041-10050	VBN	denotes	indicated
T7951	10027-10036	NNS	denotes	standards
T7950	10018-10026	JJ	denotes	Internal
T7949	10017-10066	sentence	denotes	Internal standards are indicated by an asterisk.
T7948	10016-10017	.	denotes	.
T7947	10006-10016	NN	denotes	deficiency
T7946	10001-10005	NN	denotes	MCAD
T7945	9996-10000	IN	denotes	with
T7944	9982-9987	JJ	denotes	human
T7943	9988-9995	NN	denotes	patient
T7942	9980-9981	DT	denotes	a
T7941	9977-9979	IN	denotes	to
T7940	9968-9976	VBN	denotes	compared
T7939	9960-9961	SYM	denotes	−
T7938	9959-9960	HYPH	denotes	/
T7937	9958-9959	SYM	denotes	−
T7936	9954-9958	NN	denotes	MCAD
T7935	9962-9967	NN	denotes	mouse
T7934	9951-9953	DT	denotes	an
T7933	9948-9950	IN	denotes	of
T7932	9926-9939	NN	denotes	acylcarnitine
T7931	9921-9925	NN	denotes	Bile
T7930	9919-9920	-RRB-	denotes	)
T7929	9940-9947	NN	denotes	profile
T7928	9918-9919	LS	denotes	C
T7927	9917-9918	-LRB-	denotes	(
T7926	9916-10017	sentence	denotes	(C) Bile acylcarnitine profile of an MCAD−/− mouse compared to a human patient with MCAD deficiency.
T7925	9915-9916	.	denotes	.
T7924	9910-9915	CD	denotes	0.001
T7923	9908-9909	SYM	denotes	<
T7922	9906-9907	NN	denotes	p
T7921	9896-9905	VBZ	denotes	indicates
T7920	9887-9895	NN	denotes	Asterisk
T7919	9886-9916	sentence	denotes	Asterisk indicates p < 0.001.
T7918	9885-9886	.	denotes	.
T7917	9883-9885	NN	denotes	SD
T7916	9881-9882	SYM	denotes	±
T7915	9874-9880	NNS	denotes	values
T7914	9869-9873	NN	denotes	mean
T7913	9859-9864	VBN	denotes	shown
T7912	9865-9868	VBP	denotes	are
T7911	9852-9858	NNS	denotes	Values
T7910	9851-9886	sentence	denotes	Values shown are mean values ± SD.
T7909	9850-9851	.	denotes	.
T7908	9841-9850	VBN	denotes	indicated
T7907	9838-9840	IN	denotes	as
T7906	9836-9837	-RRB-	denotes	)
T7905	9835-9836	NN	denotes	A
T7904	9834-9835	-LRB-	denotes	(
T7903	9831-9833	IN	denotes	in
T7902	9825-9830	VBN	denotes	shown
T7901	9815-9819	JJ	denotes	same
T7900	9820-9824	NNS	denotes	mice
T7899	9811-9814	DT	denotes	the
T7898	9808-9810	IN	denotes	of
T7897	9793-9807	NNS	denotes	acylcarnitines
T7896	9788-9792	NN	denotes	bile
T7895	9785-9787	IN	denotes	in
T7894	9774-9784	NNS	denotes	elevations
T7893	9762-9773	JJ	denotes	significant
T7892	9752-9757	EX	denotes	There
T7891	9750-9751	-RRB-	denotes	)
T7890	9758-9761	VBP	denotes	are
T7889	9749-9750	LS	denotes	B
T7888	9748-9749	-LRB-	denotes	(
T7887	9747-9851	sentence	denotes	(B) There are significant elevations in bile acylcarnitines of the same mice shown in (A) as indicated.
T7886	9746-9747	.	denotes	.
T7885	9742-9746	CD	denotes	0.01
T7884	9740-9741	SYM	denotes	<
T7883	9738-9739	NN	denotes	p
T7882	9728-9737	VBZ	denotes	indicates
T7881	9726-9727	SYM	denotes	‡
T7880	9722-9725	CC	denotes	and
T7879	9716-9721	CD	denotes	0.002
T7878	9714-9715	SYM	denotes	<
T7877	9712-9713	NN	denotes	p
T7876	9702-9711	VBZ	denotes	indicates
T7875	9693-9701	NN	denotes	Asterisk
T7874	9692-9747	sentence	denotes	Asterisk indicates p < 0.002 and ‡ indicates p < 0.01.
T7873	9691-9692	.	denotes	.
T7872	9690-9691	-RRB-	denotes	)
T7871	9688-9690	NN	denotes	SD
T7870	9687-9688	-LRB-	denotes	(
T7869	9677-9686	NN	denotes	deviation
T7868	9668-9676	JJ	denotes	standard
T7867	9666-9667	SYM	denotes	±
T7866	9659-9665	NNS	denotes	values
T7865	9654-9658	NN	denotes	mean
T7864	9644-9649	VBN	denotes	shown
T7863	9650-9653	VBP	denotes	are
T7862	9637-9643	NNS	denotes	Values
T7861	9636-9692	sentence	denotes	Values shown are mean values ± standard deviation (SD).
T7860	9635-9636	.	denotes	.
T7859	9629-9630	SYM	denotes	−
T7858	9628-9629	HYPH	denotes	/
T7857	9627-9628	SYM	denotes	−
T7856	9631-9635	NNS	denotes	mice
T7855	9623-9627	NN	denotes	MCAD
T7854	9620-9622	IN	denotes	in
T7853	9610-9619	VBN	denotes	indicated
T7852	9607-9609	IN	denotes	as
T7851	9599-9606	NNS	denotes	species
T7850	9585-9598	NN	denotes	acylcarnitine
T7849	9582-9584	IN	denotes	in
T7848	9571-9581	NNS	denotes	elevations
T7847	9559-9570	JJ	denotes	significant
T7846	9555-9558	VBP	denotes	are
T7845	9549-9554	EX	denotes	There
T7844	9548-9636	sentence	denotes	There are significant elevations in acylcarnitine species as indicated in MCAD−/− mice.
T7843	9547-9548	-RRB-	denotes	)
T7842	9544-9545	SYM	denotes	=
T7841	9542-9543	NN	denotes	n
T7840	9546-9547	CD	denotes	4
T7839	9541-9542	-LRB-	denotes	(
T7838	9534-9535	SYM	denotes	−
T7837	9533-9534	HYPH	denotes	/
T7836	9532-9533	SYM	denotes	−
T7835	9528-9532	NN	denotes	MCAD
T7834	9524-9527	CC	denotes	and
T7833	9522-9523	-RRB-	denotes	)
T7832	9519-9520	SYM	denotes	=
T7831	9517-9518	NN	denotes	n
T7830	9521-9522	CD	denotes	4
T7829	9516-9517	-LRB-	denotes	(
T7828	9514-9515	SYM	denotes	+
T7827	9513-9514	HYPH	denotes	/
T8094	10987-10988	.	denotes	.
T8093	10981-10982	SYM	denotes	−
T8092	10980-10981	HYPH	denotes	/
T8091	10979-10980	SYM	denotes	−
T8090	10983-10987	NNS	denotes	mice
T8089	10975-10979	NN	denotes	MCAD
T8088	10972-10974	IN	denotes	in
T8087	10954-10961	JJ	denotes	hepatic
T8086	10939-10953	JJ	denotes	macrovesicular
T8085	10935-10938	CC	denotes	and
T8084	10920-10934	JJ	denotes	microvesicular
T8083	10912-10919	JJ	denotes	diffuse
T8082	10908-10911	CC	denotes	and
T8081	10962-10971	NN	denotes	steatosis
T8080	10901-10907	JJ	denotes	severe
T8079	10892-10900	VBD	denotes	revealed
T8078	10877-10882	NN	denotes	liver
T8077	10883-10891	NNS	denotes	sections
T8076	10869-10876	VBN	denotes	stained
T8075	10863-10866	JJ	denotes	Red
T8074	10862-10863	HYPH	denotes	-
T8073	10867-10868	NN	denotes	O
T8072	10859-10862	NN	denotes	Oil
T8071	10858-10988	sentence	denotes	Oil-Red O stained liver sections revealed severe and diffuse microvesicular and macrovesicular hepatic steatosis in MCAD−/− mice.
T8070	10857-10858	.	denotes	.
T8069	10850-10851	HYPH	denotes	-
T8068	10851-10852	NN	denotes	h
T8067	10848-10850	CD	denotes	24
T8066	10853-10857	NN	denotes	fast
T8065	10846-10847	DT	denotes	a
T8064	10836-10845	VBG	denotes	following
T8063	10830-10835	NN	denotes	mouse
T8062	10827-10828	HYPH	denotes	/
T8061	10826-10827	NN	denotes	−
T8060	10828-10829	NN	denotes	−
T8059	10822-10826	NN	denotes	MCAD
T8058	10819-10821	IN	denotes	in
T8057	10801-10802	-RRB-	denotes	)
T8056	10803-10818	NN	denotes	Hepatosteatosis
T8055	10800-10801	LS	denotes	B
T8054	10799-10800	-LRB-	denotes	(
T8053	10798-10858	sentence	denotes	(B) Hepatosteatosis in MCAD−/− mouse following a 24-h fast.
T8052	10797-10798	.	denotes	.
T8051	10792-10797	NN	denotes	stain
T8050	10786-10789	JJ	denotes	Red
T8049	10785-10786	HYPH	denotes	-
T8048	10790-10791	NN	denotes	O
T8047	10782-10785	NN	denotes	Oil
T8046	10777-10781	IN	denotes	with
T8045	10769-10776	NN	denotes	section
T8044	10763-10768	NN	denotes	Liver
T8043	10762-10798	sentence	denotes	Liver section with Oil-Red O stain.
T7826	9512-9513	SYM	denotes	+
T7825	9536-9540	NNS	denotes	mice
T7824	9508-9512	NN	denotes	MCAD
T7823	9505-9507	IN	denotes	of
T7822	9482-9495	NN	denotes	acylcarnitine
T7821	9476-9481	NN	denotes	Serum
T7820	9474-9475	-RRB-	denotes	)
T7819	9496-9504	NN	denotes	analysis
T7818	9473-9474	LS	denotes	A
T7817	9472-9473	-LRB-	denotes	(
T7816	9471-9548	sentence	denotes	(A) Serum acylcarnitine analysis of MCAD+/+ (n = 4) and MCAD−/− mice (n = 4)
T7815	9463-9471	NNS	denotes	Analyses
T7814	9449-9462	NN	denotes	Acylcarnitine
T3587	11888-11889	.	denotes	.
T3586	11874-11881	NN	denotes	adipose
T3585	11882-11888	NN	denotes	tissue
T3584	11865-11873	JJ	denotes	adjacent
T3583	11858-11864	IN	denotes	within
T3582	11843-11847	VBD	denotes	were
T3581	11848-11857	VBN	denotes	scattered
T3506	11450-11454	VBD	denotes	were
T3505	11422-11428	NNS	denotes	Nuclei
T3504	11421-11509	sentence	denotes	Nuclei of affected myocytes were large, pale, and vesicular and had prominent nucleoli.
T3503	11420-11421	.	denotes	.
T3502	11399-11411	JJ	denotes	eosinophilic
T3501	11412-11420	NN	denotes	material
T3500	11390-11398	JJ	denotes	granular
T3499	11383-11389	RB	denotes	finely
T3498	11378-11382	IN	denotes	with
T3497	11367-11377	NNS	denotes	myofibrils
T3496	11364-11366	IN	denotes	of
T3495	11350-11352	,	denotes	,
T3494	11340-11350	NN	denotes	sarcoplasm
T3493	11336-11339	DT	denotes	the
T3492	11333-11335	IN	denotes	of
T3491	11324-11332	NNS	denotes	portions
T3490	11352-11363	NN	denotes	replacement
T3489	11321-11323	IN	denotes	in
T3488	11319-11321	,	denotes	,
T3487	11316-11319	CC	denotes	and
T3486	11314-11316	,	denotes	,
T3485	11306-11314	NN	denotes	staining
T3484	11301-11305	JJ	denotes	pale
T3483	11299-11301	,	denotes	,
T3482	11291-11299	VBG	denotes	swelling
T3481	11273-11281	NNS	denotes	myocytes
T3480	11260-11272	VBG	denotes	degenerating
T3479	11257-11259	IN	denotes	in
T3478	11282-11290	VBD	denotes	included
T3477	11249-11256	NNS	denotes	Changes
T3476	11248-11421	sentence	denotes	Changes in degenerating myocytes included swelling, pale staining, and, in portions of the sarcoplasm, replacement of myofibrils with finely granular eosinophilic material.
T3475	11247-11248	.	denotes	.
T3474	11246-11247	-RRB-	denotes	)
T3473	11244-11246	CD	denotes	5D
T3472	11240-11243	CC	denotes	and
T3471	11230-11236	NN	denotes	Figure
T3470	11237-11239	CD	denotes	5C
T3469	11229-11230	-LRB-	denotes	(
T3468	11220-11228	NN	denotes	necrosis
T3467	11216-11219	CC	denotes	and
T3466	11195-11202	NN	denotes	myocyte
T3465	11184-11194	JJ	denotes	multifocal
T3464	11177-11183	JJ	denotes	active
T3463	11203-11215	NN	denotes	degeneration
T3462	11169-11176	JJ	denotes	chronic
T3461	11164-11168	IN	denotes	with
T3460	11149-11163	NN	denotes	cardiomyopathy
T3459	11141-11148	JJ	denotes	diffuse
T3458	11129-11130	SYM	denotes	−
T3457	11128-11129	HYPH	denotes	/
T3456	11127-11128	SYM	denotes	−
T3455	11123-11127	NN	denotes	MCAD
T3454	11131-11136	NN	denotes	mouse
T3453	11120-11122	DT	denotes	an
T3452	11118-11120	,	denotes	,
T3451	11111-11118	NN	denotes	example
T3450	11107-11110	CD	denotes	one
T3449	11137-11140	VBD	denotes	had
T3448	11104-11106	IN	denotes	In
T3447	10632-11248	sentence	denotes	Figure 5 Histopathology of MCAD+/+ and MCAD−/− Mice (A) MCAD+/+ mice had no evidence of hepatic steatosis following a 24-h fast. Liver section with Oil-Red O stain. (B) Hepatosteatosis in MCAD−/− mouse following a 24-h fast. Oil-Red O stained liver sections revealed severe and diffuse microvesicular and macrovesicular hepatic steatosis in MCAD−/− mice. (C and D) Diffuse cardiomyopathy with chronic active multifocal myocyte degeneration and necrosis in MCAD−/− mice. In one example, an MCAD−/− mouse had diffuse cardiomyopathy with chronic active multifocal myocyte degeneration and necrosis (Figure 5C and 5D).
T3446	10631-10632	.	denotes	.
T3445	10625-10626	SYM	denotes	−
T3444	10624-10625	HYPH	denotes	/
T3443	10623-10624	SYM	denotes	−
T3442	10619-10623	NN	denotes	MCAD
T3441	10627-10631	NNS	denotes	mice
T3440	10610-10618	JJ	denotes	multiple
T3439	10607-10609	IN	denotes	in
T3438	10591-10598	JJ	denotes	cardiac
T3437	10599-10606	NNS	denotes	lesions
T3436	10582-10590	JJ	denotes	sporadic
T3435	10573-10575	PRP	denotes	we
T3434	10571-10573	,	denotes	,
T3433	10563-10571	NN	denotes	addition
T3432	10576-10581	VBD	denotes	found
T3431	10560-10562	IN	denotes	In
T3430	10559-10632	sentence	denotes	In addition, we found sporadic cardiac lesions in multiple MCAD−/− mice.
T3429	10558-10559	.	denotes	.
T3428	10549-10558	NN	denotes	steatosis
T3427	10541-10548	JJ	denotes	hepatic
T3426	10526-10528	,	denotes	,
T3425	10517-10526	RB	denotes	therefore
T3424	10515-10517	,	denotes	,
T3423	10528-10540	VBD	denotes	demonstrated
T3422	10509-10510	SYM	denotes	−
T3421	10508-10509	HYPH	denotes	/
T3420	10507-10508	SYM	denotes	−
T3419	10503-10507	NN	denotes	MCAD
T3418	10497-10502	JJR	denotes	older
T3417	10493-10496	DT	denotes	the
T3416	10511-10515	NNS	denotes	mice
T3415	10488-10492	RB	denotes	Only
T3414	10487-10559	sentence	denotes	Only the older MCAD−/− mice, therefore, demonstrated hepatic steatosis.
T3413	10486-10487	.	denotes	.
T3412	10477-10486	VBN	denotes	evaluated
T3411	10470-10476	NNS	denotes	organs
T3410	10466-10469	DT	denotes	all
T3409	10463-10465	IN	denotes	in
T3408	10449-10462	NNS	denotes	abnormalities
T3407	10446-10448	DT	denotes	no
T3406	10443-10445	IN	denotes	to
T3405	10435-10442	JJ	denotes	minimal
T3404	10424-10429	EX	denotes	there
T3403	10422-10424	,	denotes	,
T3402	10420-10421	HYPH	denotes	-
T3401	10421-10422	NN	denotes	h
T3400	10418-10420	CD	denotes	24
T3399	10414-10417	IN	denotes	for
T3398	10407-10413	VBN	denotes	fasted
T3397	10400-10401	SYM	denotes	−
T3396	10399-10400	HYPH	denotes	/
T3395	10398-10399	SYM	denotes	−
T3394	10394-10398	NN	denotes	MCAD
T3393	10390-10393	CC	denotes	and
T3392	10388-10389	SYM	denotes	+
T3391	10387-10388	HYPH	denotes	/
T3390	10386-10387	SYM	denotes	+
T3389	10382-10386	NN	denotes	MCAD
T3388	10402-10406	NNS	denotes	mice
T3387	10377-10378	HYPH	denotes	-
T3386	10378-10381	JJ	denotes	old
T3385	10374-10375	HYPH	denotes	-
T3384	10375-10377	NN	denotes	wk
T3383	10373-10374	CD	denotes	4
T3382	10370-10372	IN	denotes	of
T3381	10364-10369	NN	denotes	group
T3380	10356-10363	DT	denotes	another
T3379	10430-10434	VBD	denotes	were
T3378	10353-10355	IN	denotes	In
T3377	10352-10487	sentence	denotes	In another group of 4-wk-old MCAD+/+ and MCAD−/− mice fasted for 24-h, there were minimal to no abnormalities in all organs evaluated.
T3376	10351-10352	.	denotes	.
T3375	10350-10351	-RRB-	denotes	)
T3374	10348-10350	CD	denotes	5B
T3373	10344-10347	CC	denotes	and
T3372	10334-10340	NN	denotes	Figure
T3371	10341-10343	CD	denotes	5A
T3370	10333-10334	-LRB-	denotes	(
T3369	10314-10324	JJ	denotes	histologic
T3368	10325-10332	NNS	denotes	changes
T3367	10311-10313	DT	denotes	no
T3366	10300-10301	SYM	denotes	+
T3365	10299-10300	HYPH	denotes	/
T3364	10298-10299	SYM	denotes	+
T3363	10302-10306	NNS	denotes	mice
T3362	10294-10298	NN	denotes	MCAD
T3361	10307-10310	VBD	denotes	had
T3360	10286-10293	IN	denotes	whereas
T3359	10279-10280	SYM	denotes	−
T3358	10278-10279	HYPH	denotes	/
T3357	10277-10278	SYM	denotes	−
T3356	10273-10277	NN	denotes	MCAD
T3355	10281-10285	NNS	denotes	mice
T3354	10268-10269	HYPH	denotes	-
T3353	10269-10272	JJ	denotes	old
T3352	10265-10266	HYPH	denotes	-
T3351	10266-10268	NN	denotes	wk
T3350	10263-10264	SYM	denotes	–
T3349	10264-10265	CD	denotes	8
T3348	10262-10263	CD	denotes	6
T3347	10259-10261	IN	denotes	in
T3346	10241-10248	JJ	denotes	hepatic
T3345	10226-10240	JJ	denotes	macrovesicular
T3344	10222-10225	CC	denotes	and
T3343	10207-10221	JJ	denotes	microvesicular
T3342	10249-10258	NN	denotes	steatosis
T3341	10199-10206	JJ	denotes	diffuse
T3340	10178-10179	HYPH	denotes	-
T3339	10179-10180	NN	denotes	h
T3338	10176-10178	CD	denotes	24
T3337	10181-10185	NN	denotes	fast
T3336	10174-10175	DT	denotes	a
T3335	10168-10173	IN	denotes	after
T3334	10155-10162	NN	denotes	control
T3333	10153-10154	SYM	denotes	+
T3332	10152-10153	HYPH	denotes	/
T3331	10151-10152	SYM	denotes	+
T3330	10147-10151	NN	denotes	MCAD
T3329	10143-10146	CC	denotes	and
T3328	10163-10167	NNS	denotes	mice
T3327	10136-10142	NN	denotes	mutant
T3326	10133-10135	IN	denotes	of
T3325	10127-10132	NN	denotes	group
T3324	10123-10126	CD	denotes	one
T3323	10120-10122	IN	denotes	of
T3322	10186-10198	VBD	denotes	demonstrated
T3321	10092-10107	JJ	denotes	histopathologic
T3320	10108-10119	NN	denotes	examination
T3319	10083-10091	JJ	denotes	Complete
T3318	10082-10352	sentence	denotes	Complete histopathologic examination of one group of mutant and MCAD+/+ control mice after a 24-h fast demonstrated diffuse microvesicular and macrovesicular hepatic steatosis in 6–8-wk-old MCAD−/− mice whereas MCAD+/+ mice had no histologic changes (Figure 5A and 5B).
T3317	10068-10082	NN	denotes	Histopathology
T3078	8934-8951	NN	denotes	decenoylcarnitine
T3077	8928-8933	NN	denotes	serum
T3076	8925-8927	IN	denotes	of
T3075	8952-8959	JJ	denotes	evident
T3074	8909-8910	HYPH	denotes	-
T3073	8910-8914	JJ	denotes	fold
T3072	8905-8907	IN	denotes	to
T3071	8903-8904	HYPH	denotes	-
T3070	8908-8909	CD	denotes	6
T3069	8902-8903	CD	denotes	5
T3068	8915-8924	NN	denotes	elevation
T3067	8900-8901	DT	denotes	a
T3066	8896-8899	VBD	denotes	had
T3065	8889-8890	SYM	denotes	−
T3064	8888-8889	HYPH	denotes	/
T3063	8887-8888	SYM	denotes	−
T3062	8891-8895	NNS	denotes	mice
T3061	8883-8887	NN	denotes	MCAD
T3060	8879-8882	CC	denotes	but
T3059	8877-8879	,	denotes	,
T3058	8871-8872	SYM	denotes	−
T3057	8870-8871	HYPH	denotes	/
T3056	8869-8870	SYM	denotes	−
T3055	8865-8869	NN	denotes	MCAD
T3054	8861-8864	CC	denotes	and
T3053	8859-8860	SYM	denotes	+
T3052	8858-8859	HYPH	denotes	/
T3051	8857-8858	SYM	denotes	+
T3050	8873-8877	NNS	denotes	mice
T3049	8853-8857	NN	denotes	MCAD
T3048	8845-8852	IN	denotes	between
T3047	8820-8829	NN	denotes	carnitine
T3046	8814-8819	NN	denotes	serum
T3045	8830-8844	NNS	denotes	concentrations
T3044	8808-8813	JJ	denotes	total
T3043	8805-8807	IN	denotes	in
T3042	8781-8792	JJ	denotes	significant
T3041	8793-8804	NNS	denotes	differences
T3040	8778-8780	DT	denotes	no
T3039	8762-8763	SYM	denotes	−
T3038	8761-8762	HYPH	denotes	/
T3037	8760-8761	SYM	denotes	−
T3036	8756-8760	NN	denotes	MCAD
T3035	8752-8755	CC	denotes	and
T3034	8750-8751	SYM	denotes	+
T3033	8749-8750	HYPH	denotes	/
T3032	8748-8749	SYM	denotes	+
T3031	8764-8768	NNS	denotes	mice
T3030	8744-8748	NN	denotes	MCAD
T3029	8741-8743	IN	denotes	of
T3028	8769-8777	VBD	denotes	revealed
T3027	8730-8740	NN	denotes	Comparison
T3026	8729-9001	sentence	denotes	Comparison of MCAD+/+ and MCAD−/− mice revealed no significant differences in total serum carnitine concentrations between MCAD+/+ and MCAD−/− mice, but MCAD−/− mice had a 5- to 6-fold elevation of serum decenoylcarnitine evident in the acylcarnitine profile (Figure 4A).
T3025	8728-8729	.	denotes	.
T3024	8727-8728	-RRB-	denotes	)
T3023	8718-8721	RB	denotes	not
T3022	8713-8717	NNS	denotes	data
T3021	8722-8727	VBN	denotes	shown
T3020	8712-8713	-LRB-	denotes	(
T3019	8702-8711	NNS	denotes	genotypes
T3018	8697-8701	NN	denotes	MCAD
T3017	8689-8696	IN	denotes	between
T3016	8665-8676	JJ	denotes	significant
T3015	8677-8688	NNS	denotes	differences
T3014	8662-8664	DT	denotes	no
T3013	8656-8661	VBD	denotes	found
T3012	8652-8655	CC	denotes	and
T3011	8625-8636	JJ	denotes	acetoacetic
T3010	8621-8624	CC	denotes	and
T3009	8637-8651	NNS	denotes	concentrations
T3008	8605-8606	HYPH	denotes	-
T3007	8606-8620	JJ	denotes	hydroxybutyric
T3006	8604-8605	NN	denotes	β
T3005	8589-8593	RB	denotes	also
T3004	8594-8603	VBD	denotes	evaluated
T3003	8586-8588	PRP	denotes	We
T3002	8585-8729	sentence	denotes	We also evaluated β-hydroxybutyric and acetoacetic concentrations and found no significant differences between MCAD genotypes (data not shown).
T3001	8584-8585	.	denotes	.
T3000	8574-8584	NN	denotes	deficiency
T2999	8569-8573	NN	denotes	MCAD
T2998	8566-8568	IN	denotes	to
T2997	8557-8565	JJ	denotes	specific
T2996	8553-8556	RB	denotes	not
T2995	8550-8552	VBZ	denotes	is
T2994	8545-8549	NN	denotes	acid
T2993	8538-8544	JJ	denotes	Adipic
T2992	8537-8585	sentence	denotes	Adipic acid is not specific to MCAD deficiency.
T2991	8536-8537	.	denotes	.
T2990	8535-8536	-RRB-	denotes	)
T2989	8534-8535	CD	denotes	1
T2988	8528-8533	NN	denotes	Table
T2987	8527-8528	-LRB-	denotes	(
T2986	8513-8520	JJ	denotes	organic
T2985	8508-8512	JJ	denotes	same
T2984	8521-8526	NNS	denotes	acids
T2983	8504-8507	DT	denotes	the
T2982	8501-8503	IN	denotes	of
T2981	8482-8492	JJ	denotes	detectable
T2980	8493-8500	NNS	denotes	amounts
T2979	8479-8481	DT	denotes	no
T2978	8476-8478	IN	denotes	to
T2977	8470-8475	NN	denotes	trace
T2976	8463-8469	VBD	denotes	showed
T2975	8457-8462	WDT	denotes	which
T2974	8455-8457	,	denotes	,
T2973	8445-8446	SYM	denotes	+
T2972	8444-8445	HYPH	denotes	/
T2971	8443-8444	SYM	denotes	+
T2970	8447-8455	NNS	denotes	controls
T2969	8439-8443	NN	denotes	MCAD
T2968	8436-8438	IN	denotes	to
T2967	8427-8435	VBN	denotes	compared
T2966	8424-8426	IN	denotes	as
T2965	8408-8423	NN	denotes	hexanoylglycine
T2964	8404-8407	CC	denotes	and
T2963	8390-8397	JJ	denotes	sebacic
T2962	8386-8389	CC	denotes	and
T2961	8384-8386	,	denotes	,
T2960	8377-8384	JJ	denotes	suberic
T2959	8375-8377	,	denotes	,
T2958	8398-8403	NNS	denotes	acids
T2957	8369-8375	JJ	denotes	adipic
T2956	8366-8368	IN	denotes	of
T2955	8351-8365	NNS	denotes	concentrations
T2954	8342-8350	VBN	denotes	elevated
T2953	8328-8341	RB	denotes	significantly
T2952	8311-8312	SYM	denotes	−
T2951	8310-8311	HYPH	denotes	/
T2950	8309-8310	SYM	denotes	−
T2949	8313-8317	NNS	denotes	mice
T2948	8305-8309	NN	denotes	MCAD
T2947	8303-8305	,	denotes	,
T2946	8302-8303	NN	denotes	h
T2945	8299-8301	CD	denotes	18
T2944	8295-8298	IN	denotes	for
T2943	8288-8294	VBN	denotes	fasted
T2942	8283-8287	WRB	denotes	when
T2941	8281-8283	,	denotes	,
T2940	8318-8327	VBD	denotes	developed
T2939	8269-8281	RB	denotes	Specifically
T2938	8268-8537	sentence	denotes	Specifically, when fasted for 18 h, MCAD−/− mice developed significantly elevated concentrations of adipic, suberic, and sebacic acids and hexanoylglycine as compared to MCAD+/+ controls, which showed trace to no detectable amounts of the same organic acids (Table 1).
T2937	8267-8268	.	denotes	.
T2936	8253-8258	JJ	denotes	human
T2935	8259-8267	NNS	denotes	patients
T2934	8242-8243	HYPH	denotes	-
T2933	8243-8252	JJ	denotes	deficient
T2932	8238-8242	NN	denotes	MCAD
T2931	8235-8237	IN	denotes	to
T2930	8227-8234	JJ	denotes	similar
T2929	8214-8218	NN	denotes	acid
T2928	8206-8213	JJ	denotes	organic
T2927	8219-8226	NN	denotes	profile
T2926	8203-8205	DT	denotes	an
T2925	8186-8187	SYM	denotes	−
T2924	8185-8186	HYPH	denotes	/
T2923	8184-8185	SYM	denotes	−
T2922	8188-8192	NNS	denotes	mice
T2921	8180-8184	NN	denotes	MCAD
T2920	8193-8202	VBD	denotes	developed
T2919	8175-8179	IN	denotes	that
T2918	8166-8174	VBD	denotes	revealed
T2917	8157-8165	NN	denotes	analysis
T2916	8144-8151	JJ	denotes	organic
T2915	8152-8156	NN	denotes	acid
T2914	8138-8143	NN	denotes	Urine
T2913	8137-8268	sentence	denotes	Urine organic acid analysis revealed that MCAD−/− mice developed an organic acid profile similar to MCAD-deficient human patients.
T2912	8129-8137	NN	denotes	Analysis
T2911	8115-8128	NN	denotes	Acylcarnitine
T2910	8111-8114	CC	denotes	and
T2909	8106-8110	NN	denotes	Acid
T2908	8098-8105	JJ	denotes	Organic
T2718	7767-7771	NN	denotes	MCAD
T3580	11834-11842	NNS	denotes	deposits
T3579	11826-11833	JJ	denotes	Similar
T3578	11825-11889	sentence	denotes	Similar deposits were scattered within adjacent adipose tissue.
T3577	11824-11825	.	denotes	.
T3576	11813-11814	HYPH	denotes	/
T3575	11814-11824	NN	denotes	lipofuscin
T3574	11807-11813	NN	denotes	ceroid
T3573	11804-11806	VB	denotes	be
T3572	11801-11803	TO	denotes	to
T3571	11789-11800	VBN	denotes	interpreted
T3570	11774-11775	HYPH	denotes	-
T3569	11775-11780	JJ	denotes	brown
T3568	11768-11774	JJ	denotes	yellow
T3567	11756-11767	JJ	denotes	translucent
T3566	11781-11788	NN	denotes	pigment
T3565	11747-11755	JJ	denotes	globular
T3564	11744-11746	IN	denotes	of
T3563	11732-11743	NNS	denotes	collections
T3562	11721-11731	JJ	denotes	multifocal
T3561	11718-11720	IN	denotes	by
T3560	11706-11717	VBN	denotes	accompanied
T3559	11704-11706	,	denotes	,
T3558	11690-11697	JJ	denotes	elastic
T3557	11698-11704	NN	denotes	tissue
T3556	11686-11689	DT	denotes	the
T3555	11683-11685	IN	denotes	of
T3554	11670-11682	NN	denotes	degeneration
T3553	11659-11669	JJ	denotes	multifocal
T3552	11649-11654	EX	denotes	there
T3551	11643-11648	NN	denotes	heart
T3550	11639-11642	DT	denotes	the
T3549	11636-11638	IN	denotes	of
T3548	11631-11635	NN	denotes	base
T3547	11627-11630	DT	denotes	the
T3546	11624-11626	IN	denotes	at
T3545	11618-11623	NN	denotes	aorta
T3544	11614-11617	DT	denotes	the
T3543	11611-11613	IN	denotes	of
T3542	11606-11610	NN	denotes	wall
T3541	11602-11605	DT	denotes	the
T3540	11655-11658	VBD	denotes	was
T3539	11599-11601	IN	denotes	In
T3538	11598-11825	sentence	denotes	In the wall of the aorta at the base of the heart there was multifocal degeneration of the elastic tissue, accompanied by multifocal collections of globular translucent yellow-brown pigment interpreted to be ceroid/lipofuscin.
T3537	11597-11598	.	denotes	.
T3536	11589-11597	NN	denotes	fibrosis
T3535	11586-11588	IN	denotes	by
T3534	11574-11585	VBN	denotes	accompanied
T3533	11565-11573	NNS	denotes	myocytes
T3532	11562-11564	IN	denotes	of
T3531	11557-11561	NN	denotes	loss
T3530	11547-11552	EX	denotes	there
T3529	11545-11547	,	denotes	,
T3528	11531-11539	VBN	denotes	affected
T3527	11522-11530	RB	denotes	severely
T3526	11517-11521	RBS	denotes	most
T3525	11540-11545	NNS	denotes	areas
T3524	11513-11516	DT	denotes	the
T3523	11553-11556	VBD	denotes	was
T3522	11510-11512	IN	denotes	In
T3521	11509-11598	sentence	denotes	In the most severely affected areas, there was loss of myocytes accompanied by fibrosis.
T3520	11508-11509	.	denotes	.
T3519	11500-11508	NNS	denotes	nucleoli
T3518	11490-11499	JJ	denotes	prominent
T3517	11486-11489	VBD	denotes	had
T3516	11482-11485	CC	denotes	and
T3515	11472-11481	JJ	denotes	vesicular
T3514	11468-11471	CC	denotes	and
T3513	11466-11468	,	denotes	,
T3512	11462-11466	JJ	denotes	pale
T3511	11460-11462	,	denotes	,
T3510	11455-11460	JJ	denotes	large
T3509	11441-11449	NNS	denotes	myocytes
T3508	11432-11440	VBN	denotes	affected
T3507	11429-11431	IN	denotes	of
T2783	8000-8004	NN	denotes	MCAD
T2782	7995-7999	CD	denotes	four
T2781	8008-8012	NNS	denotes	mice
T2780	7991-7994	DT	denotes	all
T2779	7989-7991	,	denotes	,
T2778	7981-7989	NN	denotes	contrast
T2777	8013-8021	VBD	denotes	survived
T2776	7978-7980	IN	denotes	In
T2775	7977-8096	sentence	denotes	In contrast, all four MCAD+/+ mice survived the 3-h cold stress, ending with an average rectal temperature of 33.6 °C.
T2774	7976-7977	.	denotes	.
T2773	7974-7976	NN	denotes	°C
T2772	7969-7973	CD	denotes	22.7
T2771	7953-7954	SYM	denotes	−
T2770	7952-7953	HYPH	denotes	/
T2769	7951-7952	SYM	denotes	−
T2768	7947-7951	NN	denotes	MCAD
T2767	7937-7946	VBG	denotes	surviving
T2766	7933-7936	CD	denotes	two
T2765	7955-7959	NNS	denotes	mice
T2764	7929-7932	DT	denotes	the
T2763	7927-7929	,	denotes	,
T2762	7920-7921	HYPH	denotes	-
T2761	7921-7922	NN	denotes	h
T2760	7917-7920	CD	denotes	1.5
T2759	7923-7927	NN	denotes	mark
T2758	7913-7916	DT	denotes	the
T2757	7910-7912	IN	denotes	of
T2756	7906-7909	NN	denotes	end
T2755	7902-7905	DT	denotes	the
T2754	7960-7968	VBD	denotes	averaged
T2753	7899-7901	IN	denotes	By
T2752	7898-7977	sentence	denotes	By the end of the 1.5-h mark, the two surviving MCAD−/− mice averaged 22.7 °C.
T2751	7897-7898	.	denotes	.
T2750	7891-7892	SYM	denotes	−
T2749	7890-7891	HYPH	denotes	/
T2748	7889-7890	SYM	denotes	−
T2747	7885-7889	NN	denotes	MCAD
T2746	7893-7897	NNS	denotes	mice
T2745	7876-7879	DT	denotes	the
T2744	7873-7875	IN	denotes	of
T2743	7880-7884	CD	denotes	five
T2742	7867-7872	CD	denotes	three
T2741	7864-7866	IN	denotes	in
T2740	7861-7863	NN	denotes	°C
T2739	7855-7856	SYM	denotes	–
T2738	7856-7860	CD	denotes	19.2
T2737	7851-7855	CD	denotes	16.7
T2736	7848-7850	IN	denotes	of
T2735	7835-7847	NNS	denotes	temperatures
T2734	7821-7834	JJ	denotes	unrecoverable
T2733	7818-7820	IN	denotes	to
T2732	7809-7817	VBD	denotes	declined
T2731	7796-7808	NNS	denotes	temperatures
T2730	7789-7795	JJ	denotes	Rectal
T2729	7788-7898	sentence	denotes	Rectal temperatures declined to unrecoverable temperatures of 16.7–19.2 °C in three of the five MCAD−/− mice.
T2728	7787-7788	.	denotes	.
T2727	7786-7787	-RRB-	denotes	)
T2726	7783-7784	SYM	denotes	=
T2725	7781-7782	NN	denotes	n
T2724	7785-7786	CD	denotes	4
T2723	7780-7781	-LRB-	denotes	(
T2722	7773-7774	SYM	denotes	+
T2721	7772-7773	HYPH	denotes	/
T2720	7771-7772	SYM	denotes	+
T2719	7775-7779	NNS	denotes	mice
T2717	7763-7766	IN	denotes	for
T2716	7760-7762	NN	denotes	°C
T2715	7757-7759	CD	denotes	35
T2714	7752-7756	IN	denotes	with
T2713	7743-7751	VBN	denotes	compared
T2712	7740-7742	IN	denotes	as
T2711	7737-7739	NN	denotes	°C
T2710	7732-7736	CD	denotes	23.4
T2709	7726-7727	-RRB-	denotes	)
T2708	7723-7724	SYM	denotes	=
T2707	7721-7722	NN	denotes	n
T2706	7725-7726	CD	denotes	5
T2705	7720-7721	-LRB-	denotes	(
T2704	7713-7714	SYM	denotes	−
T2703	7712-7713	HYPH	denotes	/
T2702	7711-7712	SYM	denotes	−
T2701	7715-7719	NNS	denotes	mice
T2700	7707-7711	NN	denotes	MCAD
T2699	7704-7706	IN	denotes	of
T2698	7685-7691	JJ	denotes	rectal
T2697	7677-7684	JJ	denotes	average
T2696	7692-7703	NN	denotes	temperature
T2695	7673-7676	DT	denotes	the
T2694	7671-7673	,	denotes	,
T2693	7657-7661	NN	denotes	cold
T2692	7662-7671	NN	denotes	challenge
T2691	7653-7656	DT	denotes	the
T2690	7650-7652	IN	denotes	of
T2689	7648-7649	NN	denotes	h
T2688	7646-7647	CD	denotes	1
T2687	7728-7731	VBD	denotes	was
T2686	7640-7645	IN	denotes	After
T2685	7639-7788	sentence	denotes	After 1 h of the cold challenge, the average rectal temperature of MCAD−/− mice (n = 5) was 23.4 °C as compared with 35 °C for MCAD+/+ mice (n = 4).
T2684	7638-7639	.	denotes	.
T2683	7628-7638	NNS	denotes	fatalities
T2682	7625-7627	IN	denotes	in
T2681	7618-7624	VB	denotes	result
T2680	7615-7617	TO	denotes	to
T2679	7608-7614	RB	denotes	enough
T2678	7601-7607	JJ	denotes	severe
T2677	7596-7600	DT	denotes	some
T2676	7594-7596	,	denotes	,
T2675	7588-7594	NN	denotes	stress
T2674	7583-7587	NN	denotes	cold
T2673	7580-7582	IN	denotes	of
T2672	7567-7572	JJ	denotes	short
T2671	7573-7579	NN	denotes	period
T2670	7562-7566	DT	denotes	this
T2669	7555-7561	IN	denotes	within
T2668	7529-7542	RB	denotes	significantly
T2667	7524-7528	VBD	denotes	were
T2666	7543-7554	VBN	denotes	compromised
T2665	7517-7518	SYM	denotes	−
T2664	7516-7517	HYPH	denotes	/
T2663	7515-7516	SYM	denotes	−
T2662	7511-7515	NN	denotes	MCAD
T2661	7519-7523	NNS	denotes	mice
T2660	7507-7510	DT	denotes	The
T2659	7506-7639	sentence	denotes	The MCAD−/− mice were significantly compromised within this short period of cold stress, some severe enough to result in fatalities.
T2658	7505-7506	.	denotes	.
T2657	7496-7497	HYPH	denotes	-
T2656	7497-7498	NN	denotes	h
T2655	7495-7496	CD	denotes	3
T2654	7499-7505	NN	denotes	period
T2653	7493-7494	DT	denotes	a
T2652	7489-7492	IN	denotes	for
T2651	7477-7488	NN	denotes	environment
T2650	7474-7476	NN	denotes	°C
T2649	7472-7473	CD	denotes	4
T2648	7469-7471	IN	denotes	in
T2647	7462-7468	VBN	denotes	placed
T2646	7458-7461	CC	denotes	and
T2645	7456-7457	NN	denotes	h
T2644	7453-7455	CD	denotes	18
T2643	7449-7452	IN	denotes	for
T2642	7437-7441	VBD	denotes	were
T2641	7432-7436	NNS	denotes	mice
T2640	7430-7432	,	denotes	,
T2639	7424-7430	NN	denotes	stress
T2638	7419-7423	NN	denotes	cold
T2637	7416-7418	IN	denotes	of
T2636	7408-7415	NNS	denotes	effects
T2635	7404-7407	DT	denotes	the
T2634	7442-7448	VBN	denotes	fasted
T2633	7394-7403	VB	denotes	determine
T2632	7391-7393	TO	denotes	To
T2631	7390-7506	sentence	denotes	To determine the effects of cold stress, mice were fasted for 18 h and placed in 4 °C environment for a 3-h period.
T2630	7389-7390	.	denotes	.
T2629	7388-7389	-RRB-	denotes	)
T2628	7387-7388	CD	denotes	1
T2627	7381-7386	NN	denotes	Table
T2626	7380-7381	-LRB-	denotes	(
T2625	7373-7374	SYM	denotes	+
T2624	7372-7373	HYPH	denotes	/
T2623	7371-7372	SYM	denotes	+
T2622	7375-7379	NNS	denotes	mice
T2621	7367-7371	NN	denotes	MCAD
T2620	7364-7366	IN	denotes	to
T2619	7355-7363	VBN	denotes	compared
T2618	7352-7354	IN	denotes	as
T2617	7350-7352	,	denotes	,
T2616	7339-7350	JJ	denotes	significant
T2615	7328-7334	NN	denotes	result
T2614	7320-7327	DT	denotes	neither
T2613	7335-7338	VBD	denotes	was
T2612	7311-7319	IN	denotes	although
T2611	7293-7298	JJ	denotes	fatty
T2610	7299-7303	NN	denotes	acid
T2609	7288-7292	JJ	denotes	free
T2608	7282-7287	NN	denotes	serum
T2607	7304-7310	NNS	denotes	levels
T2606	7273-7281	VBN	denotes	elevated
T2605	7269-7272	CC	denotes	and
T2604	7255-7260	NN	denotes	serum
T2603	7261-7268	NN	denotes	glucose
T2602	7249-7254	JJR	denotes	lower
T2601	7239-7248	VBD	denotes	displayed
T2600	7232-7233	SYM	denotes	−
T2599	7231-7232	HYPH	denotes	/
T2598	7230-7231	SYM	denotes	−
T2597	7234-7238	NNS	denotes	mice
T2596	7226-7230	NN	denotes	MCAD
T2595	7225-7390	sentence	denotes	MCAD−/− mice displayed lower serum glucose and elevated serum free fatty acid levels although neither result was significant, as compared to MCAD+/+ mice (Table 1).
T2594	7224-7225	.	denotes	.
T3178	9437-9438	.	denotes	.
T3177	9422-9423	CD	denotes	1
T3176	9421-9422	:	denotes	:
T3175	9424-9437	NN	denotes	acylcarnitine
T3174	9418-9421	NN	denotes	C10
T3173	9411-9413	PRP	denotes	it
T3172	9405-9410	NN	denotes	mouse
T3171	9401-9404	DT	denotes	the
T3170	9398-9400	IN	denotes	in
T3169	9414-9417	VBD	denotes	was
T3168	9390-9397	IN	denotes	whereas
T3167	9388-9390	,	denotes	,
T3166	9382-9388	NNS	denotes	humans
T3165	9379-9381	IN	denotes	in
T3164	9365-9378	NN	denotes	acylcarnitine
T3163	9362-9364	NN	denotes	C8
T3162	9341-9352	JJ	denotes	predominant
T3161	9353-9357	NN	denotes	peak
T3160	9337-9340	DT	denotes	the
T3159	9335-9337	,	denotes	,
T3158	9328-9335	RB	denotes	however
T3157	9326-9327	:	denotes	;
T3156	9315-9321	NN	denotes	mutant
T3155	9322-9326	NNS	denotes	mice
T3154	9311-9314	DT	denotes	the
T3153	9307-9310	VBD	denotes	did
T3152	9304-9306	IN	denotes	as
T3151	9302-9304	,	denotes	,
T3150	9288-9302	NNS	denotes	acylcarnitines
T3149	9286-9287	CD	denotes	1
T3148	9285-9286	:	denotes	:
T3147	9282-9285	NN	denotes	C10
T3146	9278-9281	CC	denotes	and
T3145	9276-9278	,	denotes	,
T3144	9274-9276	NN	denotes	C8
T3143	9272-9274	,	denotes	,
T3142	9270-9272	NN	denotes	C6
T3141	9267-9269	IN	denotes	of
T3140	9260-9266	NNS	denotes	levels
T3139	9251-9259	VBN	denotes	elevated
T3138	9246-9250	IN	denotes	with
T3137	9358-9361	VBD	denotes	was
T3136	9238-9245	VBP	denotes	present
T3135	9229-9237	NNS	denotes	patients
T3134	9223-9228	JJ	denotes	Human
T3133	9222-9438	sentence	denotes	Human patients present with elevated levels of C6, C8, and C10:1 acylcarnitines, as did the mutant mice; however, the predominant peak was C8 acylcarnitine in humans, whereas in the mouse it was C10:1 acylcarnitine.
T3132	9221-9222	.	denotes	.
T3131	9220-9221	-RRB-	denotes	)
T3130	9218-9220	CD	denotes	4C
T3129	9211-9217	NN	denotes	Figure
T3128	9210-9211	-LRB-	denotes	(
T3127	9190-9191	HYPH	denotes	-
T3126	9191-9200	JJ	denotes	deficient
T3125	9186-9190	NN	denotes	MCAD
T3124	9201-9209	NNS	denotes	patients
T3123	9180-9185	JJ	denotes	human
T3122	9177-9179	IN	denotes	of
T3121	9171-9176	DT	denotes	those
T3120	9166-9170	IN	denotes	from
T3119	9156-9165	JJ	denotes	different
T3118	9145-9146	SYM	denotes	−
T3117	9144-9145	HYPH	denotes	/
T3116	9143-9144	SYM	denotes	−
T3115	9139-9143	NN	denotes	MCAD
T3114	9147-9151	NNS	denotes	mice
T3113	9135-9138	DT	denotes	the
T3112	9132-9134	IN	denotes	of
T3111	9109-9122	NN	denotes	acylcarnitine
T3110	9123-9131	NNS	denotes	profiles
T3109	9105-9108	DT	denotes	the
T3108	9103-9105	,	denotes	,
T3107	9152-9155	VBP	denotes	are
T3106	9096-9103	RB	denotes	However
T3105	9095-9222	sentence	denotes	However, the acylcarnitine profiles of the MCAD−/− mice are different from those of human MCAD-deficient patients (Figure 4C).
T3104	9094-9095	.	denotes	.
T3103	9093-9094	-RRB-	denotes	)
T3102	9091-9093	CD	denotes	4B
T3101	9084-9090	NN	denotes	Figure
T3100	9083-9084	-LRB-	denotes	(
T3099	9077-9082	NN	denotes	serum
T3098	9074-9076	IN	denotes	in
T3097	9071-9073	IN	denotes	as
T3096	9049-9062	NN	denotes	acylcarnitine
T3095	9041-9048	JJ	denotes	similar
T3094	9063-9070	NN	denotes	pattern
T3093	9039-9040	DT	denotes	a
T3092	9030-9038	VBD	denotes	revealed
T3091	9021-9029	NN	denotes	analysis
T3090	9007-9020	NN	denotes	acylcarnitine
T3089	9002-9006	NN	denotes	Bile
T3088	9001-9095	sentence	denotes	Bile acylcarnitine analysis revealed a similar acylcarnitine pattern as in serum (Figure 4B).
T3087	9000-9001	.	denotes	.
T3086	8999-9000	-RRB-	denotes	)
T3085	8997-8999	CD	denotes	4A
T3084	8990-8996	NN	denotes	Figure
T3083	8989-8990	-LRB-	denotes	(
T3082	8967-8980	NN	denotes	acylcarnitine
T3081	8981-8988	NN	denotes	profile
T3080	8963-8966	DT	denotes	the
T3079	8960-8962	IN	denotes	in
T2593	7216-7224	NN	denotes	analysis
T2592	7213-7215	IN	denotes	to
T2591	7207-7212	JJ	denotes	prior
T2590	7205-7206	NN	denotes	h
T2589	7202-7204	CD	denotes	24
T2588	7198-7201	IN	denotes	for
T2587	7186-7190	VBD	denotes	were
T2586	7181-7185	PRP	denotes	they
T2585	7179-7181	,	denotes	,
T2584	7175-7179	NNS	denotes	mice
T2583	7164-7165	HYPH	denotes	-
T2582	7165-7174	JJ	denotes	deficient
T2581	7160-7164	NN	denotes	MCAD
T2580	7157-7159	IN	denotes	on
T2579	7149-7156	NN	denotes	fasting
T2578	7146-7148	IN	denotes	of
T2577	7131-7137	NN	denotes	stress
T2576	7138-7145	NNS	denotes	effects
T2575	7127-7130	DT	denotes	the
T2574	7119-7126	VB	denotes	examine
T2573	7116-7118	TO	denotes	to
T2572	7110-7115	NN	denotes	order
T2571	7191-7197	VBN	denotes	fasted
T2570	7107-7109	IN	denotes	In
T2569	7106-7225	sentence	denotes	In order to examine the stress effects of fasting on MCAD-deficient mice, they were fasted for 24 h prior to analysis.
T2568	7095-7106	NN	denotes	Intolerance
T2470	7075-7076	.	denotes	.
T2469	7068-7075	NNS	denotes	matings
T2468	7055-7067	JJ	denotes	heterozygous
T2467	7050-7054	IN	denotes	from
T2466	7040-7049	NNS	denotes	pedigrees
T2465	7036-7039	DT	denotes	the
T2464	7027-7035	VB	denotes	evaluate
T2463	7024-7026	TO	denotes	to
T2462	7017-7023	JJ	denotes	unable
T2461	7009-7011	PRP	denotes	we
T2460	7007-7009	,	denotes	,
T2459	7012-7016	VBD	denotes	were
T2458	7003-7007	RB	denotes	Thus
T2457	7002-7076	sentence	denotes	Thus, we were unable to evaluate the pedigrees from heterozygous matings.
T2456	7001-7002	.	denotes	.
T2455	6992-6993	SYM	denotes	−
T2454	6991-6992	HYPH	denotes	/
T2453	6990-6991	SYM	denotes	−
T2452	6986-6990	NN	denotes	MCAD
T2451	6984-6985	SYM	denotes	×
T2450	6982-6983	SYM	denotes	−
T2449	6981-6982	HYPH	denotes	/
T2448	6980-6981	SYM	denotes	−
T2447	6994-7001	NNS	denotes	matings
T2446	6976-6980	NN	denotes	MCAD
T2445	6971-6975	IN	denotes	with
T2444	6961-6962	SYM	denotes	+
T2443	6960-6961	HYPH	denotes	/
T2442	6959-6960	SYM	denotes	+
T2441	6955-6959	NN	denotes	MCAD
T2440	6953-6954	SYM	denotes	×
T2439	6951-6952	SYM	denotes	+
T2438	6950-6951	HYPH	denotes	/
T2436	6963-6970	NNS	denotes	matings
T2435	6945-6949	NN	denotes	MCAD
T2434	6932-6936	RB	denotes	only
T2433	6926-6931	MD	denotes	could
T2432	6923-6925	PRP	denotes	we
T2431	6921-6923	,	denotes	,
T2430	6903-6912	NN	denotes	insertion
T2429	6913-6921	NN	denotes	mutation
T2428	6899-6902	DT	denotes	the
T2427	6896-6898	IN	denotes	to
T2426	6892-6895	IN	denotes	due
T2425	6883-6891	NN	denotes	analysis
T2424	6873-6882	JJ	denotes	molecular
T2423	6870-6872	IN	denotes	by
T2422	6852-6864	JJ	denotes	heterozygous
T2421	6850-6851	SYM	denotes	−
T2420	6849-6850	HYPH	denotes	/
T2419	6848-6849	SYM	denotes	+
T2418	6844-6848	NN	denotes	MCAD
T2417	6865-6869	NNS	denotes	pups
T2416	6840-6843	DT	denotes	the
T2415	6835-6839	IN	denotes	from
T2414	6825-6826	SYM	denotes	−
T2413	6824-6825	HYPH	denotes	/
T2412	6823-6824	SYM	denotes	−
T2411	6819-6823	NN	denotes	MCAD
T2410	6827-6834	NNS	denotes	mutants
T2409	6815-6818	DT	denotes	the
T2408	6800-6814	VBG	denotes	distinguishing
T2407	6797-6799	IN	denotes	of
T2406	6786-6796	NN	denotes	difficulty
T2405	6782-6785	DT	denotes	the
T2404	6779-6781	IN	denotes	of
T2403	6937-6944	VB	denotes	compare
T2402	6771-6778	IN	denotes	Because
T2401	6770-7002	sentence	denotes	Because of the difficulty of distinguishing the MCAD−/− mutants from the MCAD+/− heterozygous pups by molecular analysis due to the insertion mutation, we could only compare MCAD+/+ × MCAD+/+ matings with MCAD−/− × MCAD−/− matings.
T2400	6769-6770	.	denotes	.
T2399	6768-6769	SYM	denotes	+
T2398	6767-6768	HYPH	denotes	/
T2397	6766-6767	SYM	denotes	+
T2396	6762-6766	NN	denotes	MCAD
T2395	6757-6761	IN	denotes	than
T2394	6745-6756	NN	denotes	hypothermia
T2393	6742-6744	IN	denotes	to
T2392	6736-6741	JJ	denotes	prone
T2391	6731-6735	RBR	denotes	more
T2390	6724-6730	RB	denotes	likely
T2389	6720-6723	VBP	denotes	are
T2388	6715-6719	PRP	denotes	They
T2387	6714-6770	sentence	denotes	They are likely more prone to hypothermia than MCAD+/+.
T2386	6713-6714	.	denotes	.
T2385	6706-6713	NNS	denotes	reasons
T2384	6698-6705	JJ	denotes	unknown
T2383	6694-6697	IN	denotes	for
T2382	6687-6688	SYM	denotes	+
T2381	6686-6687	HYPH	denotes	/
T2380	6685-6686	SYM	denotes	+
T2379	6689-6693	NNS	denotes	pups
T2378	6681-6685	NN	denotes	MCAD
T2377	6676-6680	IN	denotes	than
T2376	6665-6675	RB	denotes	frequently
T2375	6660-6664	RBR	denotes	more
T2374	6646-6649	VBP	denotes	are
T2373	6650-6659	VBN	denotes	abandoned
T2372	6639-6640	SYM	denotes	−
T2371	6638-6639	HYPH	denotes	/
T2370	6637-6638	SYM	denotes	−
T2369	6633-6637	NN	denotes	MCAD
T2368	6641-6645	NNS	denotes	pups
T2367	6629-6632	DT	denotes	The
T2366	6628-6714	sentence	denotes	The MCAD−/− pups are abandoned more frequently than MCAD+/+ pups for unknown reasons.
T2365	6627-6628	.	denotes	.
T2364	6615-6627	JJ	denotes	undetermined
T2363	6602-6606	NN	denotes	loss
T2362	6593-6601	JJ	denotes	neonatal
T2361	6590-6592	IN	denotes	of
T2360	6607-6614	VBZ	denotes	remains
T2359	6580-6589	NN	denotes	mechanism
T2358	6576-6579	DT	denotes	The
T2357	6575-6628	sentence	denotes	The mechanism of neonatal loss remains undetermined.
T2356	6574-6575	.	denotes	.
T2355	6573-6574	-RRB-	denotes	)
T2354	6572-6573	CD	denotes	1
T2353	6566-6571	NN	denotes	Table
T2352	6565-6566	-LRB-	denotes	(
T2351	6558-6559	SYM	denotes	+
T2350	6557-6558	HYPH	denotes	/
T2349	6556-6557	SYM	denotes	+
T2348	6560-6564	NNS	denotes	mice
T2347	6552-6556	NN	denotes	MCAD
T2346	6549-6551	IN	denotes	of
T2345	6547-6548	NN	denotes	%
T2344	6545-6547	CD	denotes	98
T2343	6542-6544	IN	denotes	to
T2342	6533-6541	VBN	denotes	compared
T2341	6530-6532	IN	denotes	as
T2340	6522-6529	NN	denotes	weaning
T2339	6519-6521	IN	denotes	to
T2338	6503-6504	SYM	denotes	−
T2337	6502-6503	HYPH	denotes	/
T2336	6501-6502	SYM	denotes	−
T2335	6505-6509	NNS	denotes	mice
T2334	6497-6501	NN	denotes	MCAD
T2333	6494-6496	IN	denotes	of
T2332	6490-6492	CD	denotes	41
T2331	6492-6493	NN	denotes	%
T2330	6485-6489	RB	denotes	only
T2329	6483-6485	,	denotes	,
T2328	6477-6478	SYM	denotes	−
T2327	6476-6477	HYPH	denotes	/
T2326	6475-6476	SYM	denotes	−
T2325	6471-6475	NN	denotes	MCAD
T2324	6467-6470	CC	denotes	and
T2323	6465-6466	SYM	denotes	+
T2322	6464-6465	HYPH	denotes	/
T2321	6463-6464	SYM	denotes	+
T2320	6479-6483	NNS	denotes	mice
T2319	6459-6463	NN	denotes	MCAD
T2318	6454-6458	IN	denotes	from
T2803	8095-8096	.	denotes	.
T2802	8093-8095	NN	denotes	°C
T2801	8088-8092	CD	denotes	33.6
T2800	8085-8087	IN	denotes	of
T2799	8066-8072	JJ	denotes	rectal
T2798	8058-8065	JJ	denotes	average
T2797	8073-8084	NN	denotes	temperature
T2796	8055-8057	DT	denotes	an
T2795	8050-8054	IN	denotes	with
T2794	8043-8049	VBG	denotes	ending
T2793	8041-8043	,	denotes	,
T2792	8030-8034	NN	denotes	cold
T2791	8027-8028	HYPH	denotes	-
T2790	8028-8029	NN	denotes	h
T2789	8026-8027	CD	denotes	3
T2788	8035-8041	NN	denotes	stress
T2787	8022-8025	DT	denotes	the
T2786	8006-8007	SYM	denotes	+
T2785	8005-8006	HYPH	denotes	/
T2784	8004-8005	SYM	denotes	+
T2317	6510-6518	VBD	denotes	survived
T2316	6444-6448	VBD	denotes	were
T2315	6439-6443	NNS	denotes	pups
T2314	6436-6438	IN	denotes	of
T2313	6428-6435	NNS	denotes	numbers
T2312	6422-6427	JJ	denotes	equal
T2311	6449-6453	VBN	denotes	born
T2310	6413-6421	IN	denotes	Although
T2309	6412-6575	sentence	denotes	Although equal numbers of pups were born from MCAD+/+ and MCAD−/− mice, only 41% of MCAD−/− mice survived to weaning as compared to 98% of MCAD+/+ mice (Table 1).
T2308	6411-6412	.	denotes	.
T2307	6405-6406	SYM	denotes	−
T2306	6404-6405	HYPH	denotes	/
T2305	6403-6404	SYM	denotes	−
T2304	6407-6411	NNS	denotes	pups
T2303	6399-6403	NN	denotes	MCAD
T2302	6396-6398	IN	denotes	in
T2301	6386-6389	VBD	denotes	was
T2300	6390-6395	VBN	denotes	noted
T2299	6367-6375	JJ	denotes	neonatal
T2298	6376-6385	NN	denotes	mortality
T2297	6355-6366	JJ	denotes	Significant
T2296	6354-6412	sentence	denotes	Significant neonatal mortality was noted in MCAD−/− pups.
T2295	6348-6354	NNS	denotes	Deaths
T2294	6339-6347	JJ	denotes	Neonatal
T2567	7090-7094	NN	denotes	Cold
T2566	7086-7089	CC	denotes	and
T2565	7078-7085	NN	denotes	Fasting
T2154	5932-5941	NN	denotes	palmitoyl
T2166	5989-6001	RB	denotes	respectively
T2167	6001-6003	,	denotes	,
T2168	6003-6005	IN	denotes	in
T2169	6006-6010	NN	denotes	MCAD
T2170	6014-6018	NNS	denotes	mice
T2171	6010-6011	SYM	denotes	−
T2172	6011-6012	HYPH	denotes	/
T2173	6012-6013	SYM	denotes	−
T2174	6019-6021	IN	denotes	as
T2175	6022-6030	VBN	denotes	compared
T2176	6031-6033	IN	denotes	to
T2177	6034-6038	NN	denotes	MCAD
T2178	6042-6050	NNS	denotes	controls
T2179	6038-6039	SYM	denotes	+
T2180	6039-6040	HYPH	denotes	/
T2181	6040-6041	SYM	denotes	+
T2182	6050-6051	.	denotes	.
R579	T964	T965	compound	Gene,Targeting
R580	T966	T965	cc	and,Targeting
R581	T967	T965	conj	Generation,Targeting
R582	T968	T967	prep	of,Generation
R583	T969	T970	npadvmod	MCAD,Deficient
R584	T970	T972	amod	Deficient,Mice
R585	T971	T970	punct	-,Deficient
R586	T972	T968	pobj	Mice,of
R587	T974	T975	compound	MCAD,vector
R588	T975	T977	nsubjpass	vector,designed
R589	T976	T975	compound	insertion,vector
R590	T978	T975	punct	(,vector
R591	T979	T980	compound	MCAD,IV2
R592	T980	T975	appos	IV2,vector
R593	T981	T977	punct	),designed
R594	T982	T977	auxpass	was,designed
R595	T983	T984	aux	to,undergo
R596	T984	T977	advcl	undergo,designed
R597	T985	T986	compound	gap,repair
R598	T986	T984	dobj	repair,undergo
R599	T987	T986	prep	of,repair
R600	T988	T989	det	the,region
R601	T989	T987	pobj	region,of
R602	T990	T991	nummod	1.3,kb
R603	T991	T989	nmod	kb,region
R604	T992	T991	punct	-,kb
R605	T993	T989	amod	deleted,region
R606	T994	T984	prep	upon,undergo
R607	T995	T996	amod	homologous,recombination
R608	T996	T994	pobj	recombination,upon
R609	T997	T984	prep	in,undergo
R610	T998	T999	nmod	129P2,cells
R611	T999	T997	pobj	cells,in
R612	T1000	T1001	punct	(,OlaHsd
R613	T1001	T999	parataxis	OlaHsd,cells
R614	T1002	T1001	compound	129P2,OlaHsd
R615	T1003	T1001	punct	/,OlaHsd
R616	T1004	T1001	punct	),OlaHsd
R617	T1005	T999	compound	ES,cells
R618	T1006	T999	appos	E14,cells
R619	T1007	T1006	punct	–,E14
R620	T1008	T1006	nummod	1,E14
R621	T1009	T977	punct	.,designed
R622	T1011	T1012	amod	Correct,targeting
R623	T1012	T1013	nsubj	targeting,resulted
R624	T1014	T1012	prep	of,targeting
R625	T1015	T1016	det	the,locus
R626	T1016	T1014	pobj	locus,of
R627	T1017	T1016	compound	MCAD,locus
R628	T1018	T1013	prep	in,resulted
R629	T1019	T1020	det	a,duplication
R630	T1020	T1018	pobj	duplication,in
R631	T1021	T1020	prep	of,duplication
R632	T1022	T1023	nmod	exons,8
R633	T1023	T1021	pobj	8,of
R634	T1024	T1023	punct	", ",8
R635	T1025	T1023	conj	9,8
R636	T1026	T1025	punct	", ",9
R637	T1027	T1025	cc	and,9
R638	T1028	T1025	conj	10,9
R639	T1029	T1020	cc	and,duplication
R640	T1030	T1020	conj	integration,duplication
R641	T1031	T1030	prep	of,integration
R642	T1032	T1033	amod	flanking,plasmid
R643	T1033	T1031	pobj	plasmid,of
R644	T1034	T1033	cc	and,plasmid
R645	T1035	T1036	compound	Neo,sequences
R646	T1036	T1033	conj	sequences,plasmid
R647	T1037	T1038	punct	(,Figure
R648	T1038	T1013	parataxis	Figure,resulted
R649	T1039	T1038	nummod	1A,Figure
R650	T1040	T1038	punct	),Figure
R651	T1041	T1013	punct	.,resulted
R652	T1043	T1044	det	The,vector
R653	T1044	T1046	nsubjpass	vector,designed
R654	T1045	T1044	compound	insertion,vector
R655	T1047	T1046	auxpass	was,designed
R656	T1048	T1049	aux	to,duplicate
R657	T1049	T1046	advcl	duplicate,designed
R658	T1050	T1051	nmod	exon,8
R659	T1051	T1049	dobj	8,duplicate
R660	T1052	T1051	punct	", ",8
R661	T1053	T1051	conj	9,8
R662	T1054	T1053	punct	", ",9
R663	T1055	T1053	cc	and,9
R664	T1056	T1053	conj	10,9
R665	T1057	T1049	prep	at,duplicate
R666	T1058	T1059	det	the,locus
R667	T1059	T1057	pobj	locus,at
R668	T1060	T1059	compound	MCAD,locus
R669	T1061	T1046	punct	.,designed
R670	T1063	T1064	nsubj	Translation,results
R671	T1065	T1063	prep	of,Translation
R672	T1066	T1067	det	the,region
R674	T1068	T1067	amod	duplicated,region
R690	T1084	T1083	compound	MCAD,monomer
R691	T1085	T1064	punct	.,results
R692	T1087	T1088	advmod	Specifically,arises
R693	T1089	T1088	punct	", ",arises
R694	T1090	T1091	det	the,codon
R695	T1091	T1088	nsubj	codon,arises
R696	T1092	T1091	amod	first,codon
R697	T1093	T1091	amod	premature,codon
R698	T1094	T1091	compound	stop,codon
R699	T1095	T1088	prep	after,arises
R700	T1096	T1095	pobj	translation,after
R701	T1097	T1096	prep	of,translation
R702	T1098	T1099	advmod	only,seven
R703	T1099	T1100	nummod	seven,acids
R704	T1100	T1097	pobj	acids,of
R705	T1101	T1100	compound	amino,acids
R706	T1102	T1100	prep	from,acids
R707	T1103	T1104	det	the,exon
R708	T1104	T1102	pobj	exon,from
R709	T1105	T1104	amod	duplicated,exon
R710	T1106	T1104	nummod	8,exon
R711	T1107	T1088	punct	.,arises
R712	T1109	T1110	det	The,monomer
R713	T1110	T1113	nsubj	monomer,missing
R714	T1111	T1110	amod	resulting,monomer
R715	T1112	T1110	compound	MCAD,monomer
R716	T1114	T1113	aux	is,missing
R717	T1115	T1116	det	the,helixes
R718	T1116	T1113	dobj	helixes,missing
R719	T1117	T1118	npadvmod	C,terminal
R720	T1118	T1120	amod	terminal,domain
R721	T1119	T1118	punct	-,terminal
R722	T1120	T1116	compound	domain,helixes
R723	T1121	T1116	compound	α,helixes
R724	T1122	T1116	punct	-,helixes
R725	T1123	T1124	dep	that,are
R726	T1124	T1116	relcl	are,helixes
R727	T1125	T1124	acomp	responsible,are
R728	T1126	T1125	prep	for,responsible
R729	T1127	T1126	pcomp	making,for
R730	T1128	T1129	compound	intersubunit,contacts
R731	T1129	T1127	dobj	contacts,making
R732	T1130	T1131	aux	to,generate
R733	T1131	T1127	advcl	generate,making
R734	T1132	T1133	det	the,homotetramer
R735	T1133	T1131	dobj	homotetramer,generate
R736	T1134	T1133	amod	functional,homotetramer
R737	T1135	T1133	compound	MCAD,homotetramer
R738	T1136	T1113	punct	.,missing
R775	T1177	T1163	punct	", ",probe
R776	T1178	T1163	acl	hybridized,probe
R777	T1179	T1178	prep	to,hybridized
R778	T1180	T1181	det	a,band
R779	T1181	T1179	pobj	band,to
R780	T1182	T1183	nummod	13.2,kb
R781	T1183	T1181	compound	kb,band
R782	T1184	T1183	punct	-,kb
R783	T1185	T1178	prep	in,hybridized
R784	T1186	T1185	pobj	addition,in
R785	T1187	T1186	prep	to,addition
R786	T1188	T1189	det	the,band
R787	T1189	T1187	pobj	band,to
R788	T1190	T1191	nummod	3.1,kb
R789	T1191	T1189	nmod	kb,band
R790	T1192	T1191	punct	-,kb
R791	T1193	T1189	amod	endogenous,band
R792	T1194	T1189	acl	indicating,band
R793	T1195	T1196	amod	targeted,insertion
R794	T1196	T1194	dobj	insertion,indicating
R795	T1197	T1196	prep	of,insertion
R796	T1198	T1199	det	the,vector
R797	T1199	T1197	pobj	vector,of
R798	T1200	T1196	prep	at,insertion
R799	T1201	T1202	det	the,locus
R800	T1202	T1200	pobj	locus,at
R801	T1203	T1202	compound	Acadm,locus
R802	T1204	T1205	punct	(,Figure
R803	T1205	T1161	parataxis	Figure,used
R804	T1206	T1205	nummod	1B,Figure
R805	T1207	T1205	punct	),Figure
R806	T1208	T1161	punct	.,used
R807	T1210	T1211	advmod	Correctly,targeted
R808	T1211	T1212	amod	targeted,clones
R809	T1212	T1215	nsubjpass	clones,microinjected
R810	T1213	T1214	compound	ES,cell
R811	T1214	T1212	compound	cell,clones
R812	T1216	T1215	auxpass	were,microinjected
R813	T1217	T1215	prep	into,microinjected
R814	T1218	T1219	nmod	B6,blastocysts
R815	T1219	T1217	pobj	blastocysts,into
R816	T1220	T1219	punct	(,blastocysts
R817	T1221	T1222	nmod	C57BL,6NTac
R818	T1222	T1219	nmod	6NTac,blastocysts
R819	T1223	T1222	punct	/,6NTac
R820	T1224	T1219	punct	),blastocysts
R821	T1225	T1226	aux	to,generate
R822	T1226	T1215	advcl	generate,microinjected
R823	T1227	T1228	amod	chimeric,mice
R824	T1228	T1226	dobj	mice,generate
R825	T1229	T1215	punct	.,microinjected
R826	T1231	T1232	amod	Chimeric,mice
R827	T1232	T1233	nsubjpass	mice,backcrossed
R828	T1234	T1233	auxpass	were,backcrossed
R829	T1235	T1233	prep	to,backcrossed
R830	T1236	T1237	preconj	both,129P2
R831	T1237	T1238	npadvmod	129P2,inbred
R832	T1238	T1241	amod	inbred,mice
R833	T1239	T1237	cc	and,129P2
R834	T1240	T1237	conj	B6,129P2
R835	T1241	T1235	pobj	mice,to
R836	T1242	T1243	aux	to,produce
R837	T1243	T1233	advcl	produce,backcrossed
R838	T1244	T1245	nmod	MCAD,mice
R839	T1245	T1243	dobj	mice,produce
R840	T1246	T1244	punct	+,MCAD
R841	T1247	T1244	punct	/,MCAD
R842	T1248	T1244	punct	−,MCAD
R843	T1249	T1244	cc	and,MCAD
R844	T1250	T1251	advmod	eventually,MCAD
R845	T1251	T1244	conj	MCAD,MCAD
R846	T1252	T1251	punct	−,MCAD
R847	T1253	T1251	punct	/,MCAD
R848	T1254	T1251	punct	−,MCAD
R849	T1255	T1243	prep	on,produce
R850	T1256	T1257	det	a,background
R851	T1257	T1255	pobj	background,on
R852	T1258	T1257	nmod	B6,background
R853	T1259	T1258	punct	/,B6
R854	T1260	T1258	nummod	129,B6
R855	T1261	T1257	amod	mixed,background
R856	T1262	T1233	punct	.,backcrossed
R857	T1264	T1265	det	The,studies
R858	T1265	T1266	nsubjpass	studies,conducted
R859	T1267	T1265	acl	described,studies
R860	T1268	T1267	advmod	here,described
R861	T1269	T1266	auxpass	were,conducted
R862	T1270	T1266	advmod	exclusively,conducted
R863	T1271	T1266	prep	on,conducted
R864	T1272	T1273	det	the,background
R865	T1273	T1271	pobj	background,on
R866	T1274	T1273	nmod	B6,background
R867	T1275	T1274	punct	/,B6
R868	T1276	T1274	nummod	129,B6
R869	T1277	T1273	amod	mixed,background
R870	T1278	T1273	prep	compared,background
R871	T1279	T1278	prep	with,compared
R872	T1280	T1281	compound	littermate,controls
R873	T1281	T1279	pobj	controls,with
R874	T1282	T1281	cc	or,controls
R875	T1283	T1284	nmod	B6,groups
R876	T1284	T1281	conj	groups,controls
R877	T1285	T1283	punct	/,B6
R878	T1286	T1283	nummod	129,B6
R879	T1287	T1284	compound	control,groups
R880	T1288	T1281	acl	maintained,controls
R881	T1289	T1288	prep	by,maintained
R882	T1290	T1289	pobj	intercrosses,by
R883	T1291	T1292	mark	as,were
R884	T1292	T1288	advcl	were,maintained
R885	T1293	T1294	det	the,mutants
R886	T1294	T1292	nsubj	mutants,were
R887	T1295	T1266	punct	.,conducted
R888	T1297	T1298	csubj	Perpetuating,proved
R889	T1299	T1300	det	this,mutation
R890	T1300	T1297	dobj	mutation,Perpetuating
R891	T1301	T1297	prep	as,Perpetuating
R892	T1302	T1303	det	a,line
R893	T1303	T1301	pobj	line,as
R894	T1304	T1303	amod	congenic,line
R895	T1305	T1303	compound	mutant,line
R896	T1306	T1303	prep	on,line
R897	T1307	T1308	det	the,background
R898	T1308	T1306	pobj	background,on
R899	T1309	T1308	compound	129P2,background
R900	T1310	T1298	oprd	impractical,proved
R901	T1311	T1298	punct	.,proved
R902	T1313	T1314	det	The,mice
R903	T1314	T1316	nsubj	mice,were
R904	T1315	T1314	compound	129P2,mice
R905	T1317	T1318	amod	poor,breeders
R906	T1318	T1316	attr	breeders,were
R907	T1319	T1316	prep	as,were
R908	T1320	T1321	amod	wild,types
R909	T1321	T1319	pobj	types,as
R910	T1322	T1321	punct	-,types
R911	T1323	T1316	punct	", ",were
R912	T1324	T1316	cc	and,were
R913	T1325	T1326	advmod	when,introduced
R914	T1326	T1327	advcl	introduced,lost
R915	T1327	T1316	conj	lost,were
R916	T1328	T1327	punct	", ",lost
R917	T1329	T1330	det	the,mutation
R918	T1330	T1327	nsubjpass	mutation,lost
R919	T1331	T1330	compound	Acadm,mutation
R920	T1332	T1327	auxpass	was,lost
R921	T1333	T1327	advmod	nearly,lost
R922	T1334	T1327	prep	on,lost
R923	T1335	T1336	det	this,background
R924	T1336	T1334	pobj	background,on
R925	T1337	T1327	prep	because,lost
R926	T1338	T1337	pcomp	of,because
R927	T1339	T1340	det	the,rate
R928	T1340	T1337	pobj	rate,because
R929	T1341	T1340	amod	high,rate
R930	T1342	T1340	prep	of,rate
R931	T1343	T1344	amod	neonatal,death
R932	T1344	T1342	pobj	death,of
R933	T1345	T1327	punct	.,lost
R934	T1347	T1348	prep	Because,proved
R935	T1349	T1347	pcomp	of,Because
R936	T1350	T1351	det	the,structure
R937	T1351	T1347	pobj	structure,Because
R938	T1352	T1351	amod	molecular,structure
R939	T1353	T1351	prep	of,structure
R940	T1354	T1355	det	the,allele
R941	T1355	T1353	pobj	allele,of
R942	T1356	T1355	amod	targeted,allele
R943	T1357	T1348	punct	", ",proved
R944	T1358	T1348	nsubj	it,proved
R945	T1359	T1360	advmod	virtually,impossible
R946	T1360	T1348	oprd	impossible,proved
R947	T1361	T1362	aux	to,distinguish
R948	T1362	T1348	xcomp	distinguish,proved
R949	T1363	T1364	det	all,genotypes
R950	T1364	T1362	dobj	genotypes,distinguish
R951	T1365	T1364	nummod	three,genotypes
R952	T1366	T1364	amod	potential,genotypes
R953	T1367	T1348	punct	.,proved
R954	T1369	T1370	nsubj	We,detect
R955	T1370	T1373	ccomp	detect,determined
R956	T1371	T1370	aux	could,detect
R957	T1372	T1370	advmod	clearly,detect
R958	T1374	T1375	det	the,presence
R959	T1375	T1370	dobj	presence,detect
R960	T1376	T1375	cc	or,presence
R961	T1377	T1375	conj	absence,presence
R962	T1378	T1375	prep	of,presence
R963	T1379	T1380	det	the,allele
R964	T1380	T1378	pobj	allele,of
R965	T1381	T1380	amod	targeted,allele
R966	T1382	T1373	punct	", ",determined
R967	T1383	T1373	advmod	however,determined
R968	T1384	T1373	punct	", ",determined
R969	T1385	T1386	mark	whether,was
R970	T1386	T1373	csubjpass	was,determined
R971	T1387	T1388	det	a,mouse
R972	T1388	T1386	nsubj	mouse,was
R973	T1389	T1388	amod	particular,mouse
R974	T1390	T1386	attr	MCAD,was
R975	T1391	T1390	punct	−,MCAD
R976	T1392	T1390	punct	/,MCAD
R977	T1393	T1390	punct	−,MCAD
R978	T1394	T1390	cc	or,MCAD
R979	T1395	T1390	conj	MCAD,MCAD
R980	T1396	T1395	punct	+,MCAD
R981	T1397	T1395	punct	/,MCAD
R982	T1398	T1395	punct	−,MCAD
R983	T1399	T1373	aux	could,determined
R984	T1400	T1373	neg	not,determined
R985	T1401	T1373	auxpass	be,determined
R986	T1402	T1373	prep	by,determined
R987	T1403	T1404	compound	Southern,blot
R988	T1404	T1402	pobj	blot,by
R989	T1405	T1404	cc	or,blot
R990	T1406	T1404	conj	PCR,blot
R991	T1407	T1404	prep	of,blot
R992	T1408	T1409	amod	genomic,DNA
R993	T1409	T1407	pobj	DNA,of
R994	T1410	T1373	punct	.,determined
R995	T1412	T1413	advmod	Ultimately,ascertained
R996	T1414	T1415	nmod	MCAD,mice
R997	T1415	T1413	nsubjpass	mice,ascertained
R998	T1416	T1414	punct	−,MCAD
R999	T1417	T1414	punct	/,MCAD
R1000	T1418	T1414	punct	−,MCAD
R1001	T1419	T1413	auxpass	were,ascertained
R1002	T1420	T1413	prep	by,ascertained
R1003	T1421	T1422	compound	immunoblot,analysis
R1004	T1422	T1420	pobj	analysis,by
R1005	T1423	T1422	prep	of,analysis
R1006	T1424	T1423	pobj	offspring,of
R1007	T1425	T1422	prep	with,analysis
R1008	T1426	T1427	amod	subsequent,perpetuation
R1009	T1427	T1425	pobj	perpetuation,with
R1010	T1428	T1427	prep	of,perpetuation
R1011	T1429	T1430	nmod	MCAD,mice
R1012	T1430	T1428	pobj	mice,of
R1013	T1431	T1429	punct	−,MCAD
R1014	T1432	T1429	punct	/,MCAD
R1015	T1433	T1429	punct	−,MCAD
R1016	T1434	T1429	cc	and,MCAD
R1017	T1435	T1429	conj	MCAD,MCAD
R1018	T1436	T1435	punct	+,MCAD
R1019	T1437	T1435	punct	/,MCAD
R1020	T1438	T1435	punct	+,MCAD
R1021	T1439	T1427	prep	as,perpetuation
R1022	T1440	T1441	amod	separate,groups
R1023	T1441	T1439	pobj	groups,as
R1024	T1442	T1413	punct	.,ascertained
R1025	T1606	T1607	compound	RNA,Analysis
R1026	T1609	T1610	compound	RT,PCR
R1027	T1610	T1612	compound	PCR,amplification
R1028	T1611	T1610	punct	-,PCR
R1029	T1612	T1613	nsubj	amplification,amplified
R1030	T1614	T1612	prep	from,amplification
R1031	T1615	T1616	nmod	exon,7
R1032	T1616	T1614	pobj	7,from
R1033	T1617	T1616	prep	to,7
R1034	T1618	T1617	pobj	11,to
R1035	T1619	T1612	prep	from,amplification
R1036	T1620	T1621	amod	total,RNA
R1037	T1621	T1619	pobj	RNA,from
R1038	T1622	T1621	compound	heart,RNA
R1039	T1623	T1624	det	the,fragment
R1040	T1624	T1613	dobj	fragment,amplified
R1041	T1625	T1624	amod	expected,fragment
R1042	T1626	T1627	nummod	600,pair
R1043	T1627	T1624	nmod	pair,fragment
R1044	T1628	T1627	punct	-,pair
R1045	T1629	T1627	nmod	base,pair
R1046	T1630	T1627	punct	(,pair
R1047	T1631	T1627	appos	bp,pair
R1048	T1632	T1624	punct	),fragment
R1049	T1633	T1624	prep	in,fragment
R1050	T1634	T1635	nmod	MCAD,mice
R1051	T1635	T1633	pobj	mice,in
R1052	T1636	T1634	punct	+,MCAD
R1053	T1637	T1634	punct	/,MCAD
R1054	T1638	T1634	punct	+,MCAD
R1055	T1639	T1634	cc	and,MCAD
R1056	T1640	T1634	conj	MCAD,MCAD
R1057	T1641	T1640	punct	+,MCAD
R1058	T1642	T1640	punct	/,MCAD
R1059	T1643	T1640	punct	−,MCAD
R1060	T1644	T1624	punct	", ",fragment
R1061	T1645	T1624	cc	and,fragment
R1062	T1646	T1647	det	a,fragment
R1063	T1647	T1624	conj	fragment,fragment
R1064	T1648	T1649	nummod	1.5,kb
R1065	T1649	T1647	compound	kb,fragment
R1066	T1650	T1649	punct	-,kb
R1067	T1651	T1647	prep	in,fragment
R1068	T1652	T1653	nmod	MCAD,mice
R1069	T1653	T1651	pobj	mice,in
R1070	T1654	T1652	punct	−,MCAD
R1071	T1655	T1652	punct	/,MCAD
R1072	T1656	T1652	punct	−,MCAD
R1073	T1657	T1658	punct	(,shown
R1074	T1658	T1613	parataxis	shown,amplified
R1075	T1659	T1658	nsubj	data,shown
R1076	T1660	T1658	neg	not,shown
R1077	T1661	T1658	punct	),shown
R1078	T1662	T1613	punct	.,amplified
R1079	T1664	T1665	compound	Sequence,analysis
R1080	T1665	T1666	nsubj	analysis,revealed
R1081	T1667	T1665	prep	of,analysis
R1082	T1668	T1669	det	the,fragment
R1083	T1669	T1667	pobj	fragment,of
R1084	T1670	T1671	nummod	1.5,kb
R1085	T1671	T1669	compound	kb,fragment
R1086	T1672	T1671	punct	-,kb
R1087	T1673	T1674	mark	that,consisted
R1088	T1674	T1666	ccomp	consisted,revealed
R1089	T1675	T1676	det	the,fragment
R1090	T1676	T1674	nsubj	fragment,consisted
R1091	T1677	T1676	amod	amplified,fragment
R1092	T1678	T1674	prep	of,consisted
R1093	T1679	T1678	pobj	exon,of
R1094	T1680	T1679	nummod	7,exon
R1095	T1681	T1679	prep	to,exon
R1096	T1682	T1681	pobj	exon,to
R1097	T1683	T1682	nummod	10,exon
R1098	T1684	T1674	prep	with,consisted
R1099	T1685	T1686	nummod	280,bp
R1100	T1686	T1684	pobj	bp,with
R1101	T1687	T1686	prep	of,bp
R1102	T1688	T1689	compound	pGEM,sequence
R1103	T1689	T1687	pobj	sequence,of
R1104	T1690	T1689	compound	plasmid,sequence
R1105	T1691	T1689	acl	followed,sequence
R1106	T1692	T1691	agent	by,followed
R1107	T1693	T1694	nmod	exons,8
R1108	T1694	T1692	pobj	8,by
R1109	T1695	T1696	punct	–,11
R1110	T1696	T1694	prep	11,8
R1111	T1697	T1666	punct	.,revealed
R1112	T1699	T1700	nsubjpass	Some,deleted
R1113	T1701	T1699	prep	of,Some
R1114	T1702	T1703	det	the,sequences
R1115	T1703	T1701	pobj	sequences,of
R1116	T1704	T1703	compound	plasmid,sequences
R1117	T1705	T1699	punct	", ",Some
R1118	T1706	T1699	cc	along,Some
R1119	T1707	T1706	dep	with,along
R1120	T1708	T1709	det	the,sequence
R1121	T1709	T1699	conj	sequence,Some
R1122	T1710	T1709	compound	pPGKNEOpA,sequence
R1123	T1711	T1700	punct	", ",deleted
R1124	T1712	T1700	auxpass	were,deleted
R1125	T1713	T1700	prep	from,deleted
R1126	T1714	T1715	det	this,mRNA
R1127	T1715	T1713	pobj	mRNA,from
R1128	T1716	T1715	amod	spliced,mRNA
R1129	T1717	T1700	punct	.,deleted
R1130	T1719	T1720	compound	Northern,blot
R1131	T1720	T1721	compound	blot,analysis
R1132	T1721	T1722	nsubj	analysis,revealed
R1133	T1723	T1724	nsubjpass	Acadm,expressed
R1134	T1724	T1722	advcl	expressed,revealed
R1135	T1725	T1724	auxpass	was,expressed
R1136	T1726	T1724	advmod	normally,expressed
R1137	T1727	T1724	prep	in,expressed
R1138	T1728	T1729	det	all,tissues
R1139	T1729	T1727	pobj	tissues,in
R1140	T1730	T1729	acl	analyzed,tissues
R1141	T1731	T1729	prep	from,tissues
R1142	T1732	T1733	nmod	MCAD,mice
R1143	T1733	T1731	pobj	mice,from
R1144	T1734	T1732	punct	+,MCAD
R1145	T1735	T1732	punct	/,MCAD
R1146	T1736	T1732	punct	+,MCAD
R1147	T1737	T1724	prep	with,expressed
R1148	T1738	T1739	det	the,expression
R1149	T1739	T1742	nsubj	expression,occurring
R1150	T1740	T1741	advmod	most,robust
R1151	T1741	T1739	amod	robust,expression
R1152	T1742	T1737	pcomp	occurring,with
R1153	T1743	T1742	prep	in,occurring
R1154	T1744	T1745	amod	brown,fat
R1155	T1745	T1743	pobj	fat,in
R1156	T1746	T1745	punct	", ",fat
R1157	T1747	T1745	conj	kidney,fat
R1158	T1748	T1747	punct	", ",kidney
R1159	T1749	T1747	conj	heart,kidney
R1160	T1750	T1749	punct	", ",heart
R1161	T1751	T1752	amod	skeletal,muscle
R1162	T1752	T1749	conj	muscle,heart
R1163	T1753	T1752	punct	", ",muscle
R1164	T1754	T1752	cc	and,muscle
R1165	T1755	T1752	conj	liver,muscle
R1166	T1756	T1724	prep	with,expressed
R1167	T1757	T1758	amod	minimal,expression
R1168	T1758	T1756	pobj	expression,with
R1169	T1759	T1758	prep	in,expression
R1170	T1760	T1761	det	the,brain
R1171	T1761	T1759	pobj	brain,in
R1172	T1762	T1761	punct	", ",brain
R1173	T1763	T1764	amod	white,fat
R1174	T1764	T1761	conj	fat,brain
R1175	T1765	T1764	punct	", ",fat
R1176	T1766	T1764	cc	and,fat
R1177	T1767	T1764	conj	testes,fat
R1178	T1768	T1769	punct	(,Figure
R1179	T1769	T1722	parataxis	Figure,revealed
R1180	T1770	T1769	nummod	2,Figure
R1181	T1771	T1769	punct	),Figure
R1182	T1772	T1722	punct	.,revealed
R1183	T1774	T1775	advmod	Interestingly,detected
R1184	T1776	T1775	punct	", ",detected
R1185	T1777	T1778	mark	although,amplified
R1186	T1778	T1775	advcl	amplified,detected
R1187	T1779	T1780	compound	RT,PCR
R1188	T1780	T1778	nsubj	PCR,amplified
R1189	T1781	T1780	punct	-,PCR
R1190	T1782	T1783	det	an,transcript
R1191	T1783	T1778	dobj	transcript,amplified
R1192	T1784	T1785	advmod	incorrectly,spliced
R1193	T1785	T1783	amod	spliced,transcript
R1194	T1786	T1783	compound	Acadm,transcript
R1195	T1787	T1775	punct	", ",detected
R1196	T1788	T1789	det	no,transcripts
R1197	T1789	T1775	nsubjpass	transcripts,detected
R1198	T1790	T1789	compound	Acadm,transcripts
R1199	T1791	T1775	auxpass	were,detected
R1200	T1792	T1775	prep	by,detected
R1201	T1793	T1794	compound	northern,blot
R1202	T1794	T1795	compound	blot,analysis
R1203	T1795	T1792	pobj	analysis,by
R1204	T1796	T1775	prep	from,detected
R1205	T1797	T1798	nmod	MCAD,mice
R1206	T1798	T1796	pobj	mice,from
R1207	T1799	T1797	punct	−,MCAD
R1208	T1800	T1797	punct	/,MCAD
R1209	T1801	T1797	punct	−,MCAD
R1210	T1802	T1775	punct	.,detected
R1211	T1804	T1805	det	These,results
R1212	T1805	T1806	nsubj	results,suggest
R1213	T1807	T1806	advmod	strongly,suggest
R1214	T1808	T1809	mark	that,is
R1215	T1809	T1806	ccomp	is,suggest
R1216	T1810	T1811	det	the,RNA
R1217	T1811	T1809	nsubj	RNA,is
R1218	T1812	T1811	compound	mutant,RNA
R1219	T1813	T1809	acomp	unstable,is
R1220	T1814	T1809	cc	and,is
R1221	T1815	T1809	conj	degraded,is
R1222	T1816	T1815	advmod	rapidly,degraded
R1223	T1817	T1809	cc	or,is
R1224	T1818	T1809	punct	", ",is
R1225	T1819	T1820	advmod	alternatively,undergoes
R1226	T1820	T1809	conj	undergoes,is
R1227	T1821	T1820	punct	", ",undergoes
R1228	T1822	T1823	npadvmod	nonsense,mediated
R1229	T1823	T1824	amod	mediated,decay
R1230	T1824	T1820	dobj	decay,undergoes
R1231	T1825	T1824	compound	RNA,decay
R1232	T1826	T1806	punct	.,suggest
R1235	T1979	T1980	compound	Liver,Enzyme
R1236	T1980	T1981	compound	Enzyme,Analyses
R1237	T1983	T1984	compound	Immunoblot,analyses
R1238	T1984	T1985	nsubj	analyses,demonstrated
R1239	T1986	T1984	prep	of,analyses
R1240	T1987	T1988	compound	liver,homogenates
R1241	T1988	T1986	pobj	homogenates,of
R1242	T1989	T1984	prep	with,analyses
R1243	T1990	T1991	amod	anti-MCAD,antisera
R1244	T1991	T1989	pobj	antisera,with
R1245	T1992	T1993	mark	that,was
R1246	T1993	T1985	ccomp	was,demonstrated
R1247	T1994	T1995	det	the,monomer
R1248	T1995	T1993	nsubj	monomer,was
R1249	T1996	T1997	nummod	42,kDa
R1250	T1997	T1995	compound	kDa,monomer
R1251	T1998	T1995	compound	MCAD,monomer
R1252	T1999	T1993	acomp	present,was
R1253	T2000	T1993	prep	in,was
R1254	T2001	T2002	nmod	MCAD,mice
R1255	T2002	T2000	pobj	mice,in
R1256	T2003	T2001	punct	+,MCAD
R1257	T2004	T2001	punct	/,MCAD
R1258	T2005	T2001	punct	+,MCAD
R1259	T2006	T2000	punct	", ",in
R1260	T2007	T2000	cc	but,in
R1261	T2008	T2007	neg	not,but
R1262	T2009	T2000	conj	in,in
R1263	T2010	T2011	nmod	MCAD,mice
R1264	T2011	T2009	pobj	mice,in
R1265	T2012	T2010	punct	−,MCAD
R1266	T2013	T2010	punct	/,MCAD
R1267	T2014	T2010	punct	−,MCAD
R1268	T2015	T2016	punct	(,Figure
R1269	T2016	T1985	parataxis	Figure,demonstrated
R1270	T2017	T2016	nummod	3,Figure
R1271	T2018	T2016	punct	),Figure
R1272	T2019	T1985	punct	.,demonstrated
R1273	T2021	T2022	prep	As,revealed
R1274	T2023	T2024	det	a,analysis
R1275	T2024	T2021	pobj	analysis,As
R1276	T2025	T2024	compound	control,analysis
R1277	T2026	T2022	punct	", ",revealed
R1278	T2027	T2028	amod	anti–short,chain
R1279	T2028	T2030	nmod	chain,dehydrogenase
R1280	T2029	T2028	punct	-,chain
R1281	T2030	T2034	nmod	dehydrogenase,SCAD
R1282	T2031	T2032	nmod	acyl,CoA
R1283	T2032	T2030	nmod	CoA,dehydrogenase
R1284	T2033	T2032	punct	-,CoA
R1285	T2034	T2036	nmod	SCAD,antisera
R1286	T2035	T2034	punct	(,SCAD
R1287	T2036	T2022	nsubj	antisera,revealed
R1288	T2037	T2034	punct	),SCAD
R1289	T2038	T2039	det	no,differences
R1290	T2039	T2022	dobj	differences,revealed
R1291	T2040	T2039	prep	in,differences
R1292	T2041	T2040	pobj	levels,in
R1293	T2042	T2041	prep	of,levels
R1294	T2043	T2042	pobj	expression,of
R1295	T2044	T2043	prep	of,expression
R1296	T2045	T2046	compound	SCAD,protein
R1297	T2046	T2044	pobj	protein,of
R1298	T2047	T2039	prep	between,differences
R1299	T2048	T2049	nmod	MCAD,mice
R1301	T2050	T2048	punct	+,MCAD
R1302	T2051	T2048	punct	/,MCAD
R1303	T2052	T2048	punct	+,MCAD
R1304	T2053	T2048	cc	and,MCAD
R1305	T2054	T2048	conj	MCAD,MCAD
R1306	T2055	T2054	punct	−,MCAD
R1307	T2056	T2054	punct	/,MCAD
R1340	T2091	T2084	cc	and,CoA
R1341	T2092	T2093	compound	palmitoyl,CoA
R1342	T2093	T2084	conj	CoA,CoA
R1343	T2094	T2093	punct	-,CoA
R1344	T2095	T2096	punct	(,C16
R1345	T2096	T2093	parataxis	C16,CoA
R1346	T2097	T2096	punct	:,C16
R1347	T2098	T2096	nummod	0,C16
R1348	T2099	T2096	punct	),C16
R1349	T2100	T2084	prep	as,CoA
R1350	T2101	T2100	pobj	substrates,as
R1351	T2102	T2066	punct	.,analyzed
R1352	T2104	T2105	nmod	MCAD,mice
R1353	T2105	T2109	nsubj	mice,had
R1354	T2106	T2104	punct	−,MCAD
R1355	T2107	T2104	punct	/,MCAD
R1356	T2108	T2104	punct	−,MCAD
R1357	T2110	T2111	det	a,reduction
R1358	T2111	T2109	dobj	reduction,had
R1359	T2112	T2111	amod	significant,reduction
R1360	T2113	T2111	prep	in,reduction
R1361	T2114	T2113	pobj	ability,in
R1362	T2115	T2116	aux	to,dehydrogenate
R1363	T2116	T2114	acl	dehydrogenate,ability
R1364	T2117	T2118	compound	octanoyl,CoA
R1365	T2118	T2116	dobj	CoA,dehydrogenate
R1366	T2119	T2118	punct	-,CoA
R1367	T2120	T2111	cc	and,reduction
R1368	T2121	T2122	det	a,reduction
R1369	T2122	T2111	conj	reduction,reduction
R1370	T2123	T2122	amod	modest,reduction
R1371	T2124	T2122	prep	in,reduction
R1372	T2125	T2124	pobj	activity,in
R1373	T2126	T2125	prep	toward,activity
R1374	T2127	T2128	compound	palmitoyl,CoA
R1375	T2128	T2126	pobj	CoA,toward
R1376	T2129	T2128	punct	-,CoA
R1377	T2130	T2109	prep	compared,had
R1378	T2131	T2130	prep	to,compared
R1379	T2132	T2133	nmod	MCAD,mice
R1380	T2133	T2131	pobj	mice,to
R1381	T2134	T2132	punct	+,MCAD
R1382	T2135	T2132	punct	/,MCAD
R1383	T2136	T2132	punct	+,MCAD
R1384	T2137	T2138	punct	(,Table
R1385	T2138	T2109	parataxis	Table,had
R1386	T2139	T2138	nummod	1,Table
R1387	T2140	T2138	punct	),Table
R1388	T2141	T2109	punct	.,had
R1389	T2143	T2144	advmod	Specifically,reduced
R1390	T2145	T2144	punct	", ",reduced
R1391	T2146	T2147	det	the,dehydrogenation
R1392	T2147	T2144	nsubjpass	dehydrogenation,reduced
R1393	T2148	T2147	prep	of,dehydrogenation
R1394	T2149	T2150	nmod	octanoyl,CoA
R1395	T2150	T2152	nmod	CoA,substrates
R1396	T2151	T2150	punct	-,CoA
R1397	T2152	T2148	pobj	substrates,of
R1398	T2153	T2150	cc	and,CoA
R1399	T2154	T2155	compound	palmitoyl,CoA
R1400	T2155	T2150	conj	CoA,CoA
R1401	T2156	T2155	punct	-,CoA
R1402	T2157	T2144	auxpass	were,reduced
R1403	T2158	T2144	prep	by,reduced
R1404	T2159	T2160	nummod	75,%
R1405	T2160	T2158	pobj	%,by
R1406	T2161	T2158	cc	and,by
R1407	T2162	T2158	conj	by,by
R1408	T2163	T2164	nummod	30,%
R1409	T2164	T2162	pobj	%,by
R1410	T2165	T2144	punct	", ",reduced
R1411	T2166	T2144	advmod	respectively,reduced
R1412	T2167	T2144	punct	", ",reduced
R1413	T2168	T2144	prep	in,reduced
R1414	T2169	T2170	nmod	MCAD,mice
R1415	T2170	T2168	pobj	mice,in
R1416	T2171	T2169	punct	−,MCAD
R1417	T2172	T2169	punct	/,MCAD
R1418	T2173	T2169	punct	−,MCAD
R1419	T2174	T2175	mark	as,compared
R1420	T2175	T2144	advcl	compared,reduced
R1421	T2176	T2175	prep	to,compared
R1422	T2177	T2178	nmod	MCAD,controls
R1423	T2178	T2176	pobj	controls,to
R1424	T2179	T2177	punct	+,MCAD
R1425	T2180	T2177	punct	/,MCAD
R1426	T2181	T2177	punct	+,MCAD
R1427	T2182	T2144	punct	.,reduced
R1428	T2294	T2295	amod	Neonatal,Deaths
R1429	T2297	T2298	amod	Significant,mortality
R1430	T2298	T2300	nsubjpass	mortality,noted
R1431	T2299	T2298	amod	neonatal,mortality
R1432	T2301	T2300	auxpass	was,noted
R1433	T2302	T2300	prep	in,noted
R1434	T2303	T2304	nmod	MCAD,pups
R1435	T2304	T2302	pobj	pups,in
R1436	T2305	T2303	punct	−,MCAD
R1437	T2306	T2303	punct	/,MCAD
R1438	T2307	T2303	punct	−,MCAD
R1439	T2308	T2300	punct	.,noted
R1440	T2310	T2311	mark	Although,born
R1441	T2311	T2317	advcl	born,survived
R1442	T2312	T2313	amod	equal,numbers
R1443	T2313	T2311	nsubjpass	numbers,born
R1444	T2314	T2313	prep	of,numbers
R1445	T2315	T2314	pobj	pups,of
R1446	T2316	T2311	auxpass	were,born
R1447	T2318	T2311	prep	from,born
R1448	T2319	T2320	nmod	MCAD,mice
R1449	T2320	T2318	pobj	mice,from
R1450	T2321	T2319	punct	+,MCAD
R1451	T2322	T2319	punct	/,MCAD
R1452	T2323	T2319	punct	+,MCAD
R1453	T2324	T2319	cc	and,MCAD
R1454	T2325	T2319	conj	MCAD,MCAD
R1455	T2326	T2325	punct	−,MCAD
R1456	T2327	T2325	punct	/,MCAD
R1457	T2328	T2325	punct	−,MCAD
R1458	T2329	T2317	punct	", ",survived
R1459	T2330	T2331	advmod	only,%
R1460	T2331	T2317	nsubj	%,survived
R1461	T2332	T2331	nummod	41,%
R1462	T2333	T2331	prep	of,%
R1463	T2334	T2335	nmod	MCAD,mice
R1464	T2335	T2333	pobj	mice,of
R1465	T2336	T2334	punct	−,MCAD
R1466	T2337	T2334	punct	/,MCAD
R1467	T2338	T2334	punct	−,MCAD
R1468	T2339	T2317	prep	to,survived
R1469	T2340	T2339	pobj	weaning,to
R1470	T2341	T2342	mark	as,compared
R1471	T2342	T2317	advcl	compared,survived
R1472	T2343	T2342	prep	to,compared
R1473	T2344	T2345	nummod	98,%
R1474	T2345	T2343	pobj	%,to
R1475	T2346	T2345	prep	of,%
R1476	T2347	T2348	nmod	MCAD,mice
R1477	T2348	T2346	pobj	mice,of
R1478	T2349	T2347	punct	+,MCAD
R1479	T2350	T2347	punct	/,MCAD
R1480	T2351	T2347	punct	+,MCAD
R1481	T2352	T2353	punct	(,Table
R1482	T2353	T2317	parataxis	Table,survived
R1483	T2354	T2353	nummod	1,Table
R1484	T2355	T2353	punct	),Table
R1485	T2356	T2317	punct	.,survived
R1486	T2358	T2359	det	The,mechanism
R1487	T2359	T2360	nsubj	mechanism,remains
R1488	T2361	T2359	prep	of,mechanism
R1489	T2362	T2363	amod	neonatal,loss
R1490	T2363	T2361	pobj	loss,of
R1491	T2364	T2360	acomp	undetermined,remains
R1492	T2365	T2360	punct	.,remains
R1493	T2367	T2368	det	The,pups
R1494	T2368	T2373	nsubjpass	pups,abandoned
R1495	T2369	T2368	nmod	MCAD,pups
R1496	T2370	T2369	punct	−,MCAD
R1497	T2371	T2369	punct	/,MCAD
R1498	T2372	T2369	punct	−,MCAD
R1499	T2374	T2373	auxpass	are,abandoned
R1500	T2375	T2376	advmod	more,frequently
R1501	T2376	T2373	advmod	frequently,abandoned
R1502	T2377	T2376	prep	than,frequently
R1503	T2378	T2379	nmod	MCAD,pups
R1504	T2379	T2377	pobj	pups,than
R1505	T2380	T2378	punct	+,MCAD
R1506	T2381	T2378	punct	/,MCAD
R1507	T2382	T2378	punct	+,MCAD
R1508	T2383	T2373	prep	for,abandoned
R1509	T2384	T2385	amod	unknown,reasons
R1510	T2385	T2383	pobj	reasons,for
R1511	T2386	T2373	punct	.,abandoned
R1512	T2388	T2389	nsubj	They,are
R1513	T2390	T2389	advmod	likely,are
R1514	T2391	T2392	advmod	more,prone
R1515	T2392	T2389	acomp	prone,are
R1516	T2393	T2392	prep	to,prone
R1517	T2394	T2393	pobj	hypothermia,to
R1518	T2395	T2392	prep	than,prone
R1519	T2396	T2395	pobj	MCAD,than
R1520	T2397	T2396	punct	+,MCAD
R1521	T2398	T2396	punct	/,MCAD
R1522	T2399	T2396	punct	+,MCAD
R1523	T2400	T2389	punct	.,are
R1524	T2402	T2403	prep	Because,compare
R1525	T2404	T2402	pcomp	of,Because
R1526	T2405	T2406	det	the,difficulty
R1527	T2406	T2402	pobj	difficulty,Because
R1528	T2407	T2406	prep	of,difficulty
R1529	T2408	T2407	pcomp	distinguishing,of
R1530	T2409	T2410	det	the,mutants
R1531	T2410	T2408	dobj	mutants,distinguishing
R1532	T2411	T2410	nmod	MCAD,mutants
R1533	T2412	T2411	punct	−,MCAD
R1534	T2413	T2411	punct	/,MCAD
R1535	T2414	T2411	punct	−,MCAD
R1536	T2415	T2408	prep	from,distinguishing
R1537	T2416	T2417	det	the,pups
R1538	T2417	T2415	pobj	pups,from
R1539	T2418	T2417	nmod	MCAD,pups
R1540	T2419	T2418	punct	+,MCAD
R1541	T2420	T2418	punct	/,MCAD
R1542	T2421	T2418	punct	−,MCAD
R1543	T2422	T2417	amod	heterozygous,pups
R1544	T2423	T2408	prep	by,distinguishing
R1545	T2424	T2425	amod	molecular,analysis
R1546	T2425	T2423	pobj	analysis,by
R1547	T2426	T2406	prep	due,difficulty
R1548	T2427	T2426	pcomp	to,due
R1549	T2428	T2429	det	the,mutation
R1550	T2429	T2426	pobj	mutation,due
R1551	T2430	T2429	compound	insertion,mutation
R1552	T2431	T2403	punct	", ",compare
R1553	T2432	T2403	nsubj	we,compare
R1554	T2433	T2403	aux	could,compare
R1555	T2434	T2403	advmod	only,compare
R1556	T2435	T2436	nmod	MCAD,matings
R1557	T2436	T2403	dobj	matings,compare
R1558	T2437	T2435	punct	+,MCAD
R1559	T2438	T2435	punct	/,MCAD
R1560	T2439	T2435	punct	+,MCAD
R1561	T2440	T2435	punct	×,MCAD
R1562	T2441	T2435	appos	MCAD,MCAD
R1563	T2442	T2441	punct	+,MCAD
R1564	T2443	T2441	punct	/,MCAD
R1565	T2444	T2441	punct	+,MCAD
R1566	T2445	T2403	prep	with,compare
R1567	T2446	T2447	nmod	MCAD,matings
R1568	T2447	T2445	pobj	matings,with
R1569	T2448	T2446	punct	−,MCAD
R1570	T2449	T2446	punct	/,MCAD
R1571	T2450	T2446	punct	−,MCAD
R1572	T2451	T2446	punct	×,MCAD
R1573	T2452	T2446	appos	MCAD,MCAD
R1574	T2453	T2452	punct	−,MCAD
R1575	T2454	T2452	punct	/,MCAD
R1576	T2455	T2452	punct	−,MCAD
R1577	T2456	T2403	punct	.,compare
R1578	T2458	T2459	advmod	Thus,were
R1579	T2460	T2459	punct	", ",were
R1580	T2461	T2459	nsubj	we,were
R1581	T2462	T2459	acomp	unable,were
R1582	T2463	T2464	aux	to,evaluate
R1583	T2464	T2462	xcomp	evaluate,unable
R1584	T2465	T2466	det	the,pedigrees
R1585	T2466	T2464	dobj	pedigrees,evaluate
R1586	T2467	T2464	prep	from,evaluate
R1587	T2468	T2469	amod	heterozygous,matings
R1588	T2469	T2467	pobj	matings,from
R1589	T2470	T2459	punct	.,were
R1590	T2566	T2565	cc	and,Fasting
R1591	T2567	T2568	compound	Cold,Intolerance
R1592	T2568	T2565	conj	Intolerance,Fasting
R1593	T2570	T2571	prep	In,fasted
R1594	T2572	T2570	pobj	order,In
R1595	T2573	T2574	aux	to,examine
R1596	T2574	T2572	acl	examine,order
R1597	T2575	T2576	det	the,effects
R1598	T2576	T2574	dobj	effects,examine
R1599	T2577	T2576	compound	stress,effects
R1600	T2578	T2576	prep	of,effects
R1601	T2579	T2578	pobj	fasting,of
R1602	T2580	T2576	prep	on,effects
R1603	T2581	T2582	npadvmod	MCAD,deficient
R1604	T2582	T2584	amod	deficient,mice
R1605	T2583	T2582	punct	-,deficient
R1606	T2584	T2580	pobj	mice,on
R1607	T2585	T2571	punct	", ",fasted
R1608	T2586	T2571	nsubjpass	they,fasted
R1609	T2587	T2571	auxpass	were,fasted
R1610	T2588	T2571	prep	for,fasted
R1611	T2589	T2590	nummod	24,h
R1612	T2590	T2588	pobj	h,for
R1613	T2591	T2592	amod	prior,to
R1614	T2592	T2571	prep	to,fasted
R1615	T2593	T2592	pobj	analysis,to
R1616	T2594	T2571	punct	.,fasted
R1617	T2596	T2597	nmod	MCAD,mice
R1618	T2597	T2601	nsubj	mice,displayed
R1619	T2598	T2596	punct	−,MCAD
R1620	T2599	T2596	punct	/,MCAD
R1621	T2600	T2596	punct	−,MCAD
R1622	T2602	T2603	amod	lower,glucose
R1623	T2603	T2601	dobj	glucose,displayed
R1624	T2604	T2603	compound	serum,glucose
R1625	T2605	T2603	cc	and,glucose
R1626	T2606	T2607	amod	elevated,levels
R1627	T2607	T2603	conj	levels,glucose
R1628	T2608	T2609	npadvmod	serum,free
R1629	T2609	T2610	amod	free,acid
R1630	T2610	T2607	compound	acid,levels
R1631	T2611	T2610	amod	fatty,acid
R1632	T2612	T2613	mark	although,was
R1633	T2613	T2601	advcl	was,displayed
R1634	T2614	T2615	det	neither,result
R1635	T2615	T2613	nsubj	result,was
R1636	T2616	T2613	acomp	significant,was
R1637	T2617	T2613	punct	", ",was
R1638	T2618	T2619	mark	as,compared
R1639	T2619	T2613	advcl	compared,was
R1640	T2620	T2619	prep	to,compared
R1641	T2621	T2622	nmod	MCAD,mice
R1642	T2622	T2620	pobj	mice,to
R1643	T2623	T2621	punct	+,MCAD
R1644	T2624	T2621	punct	/,MCAD
R1645	T2625	T2621	punct	+,MCAD
R1646	T2626	T2627	punct	(,Table
R1647	T2627	T2601	parataxis	Table,displayed
R1648	T2628	T2627	nummod	1,Table
R1649	T2629	T2627	punct	),Table
R1650	T2630	T2601	punct	.,displayed
R1651	T2632	T2633	aux	To,determine
R1652	T2633	T2634	advcl	determine,fasted
R1653	T2635	T2636	det	the,effects
R1654	T2636	T2633	dobj	effects,determine
R1655	T2637	T2636	prep	of,effects
R1656	T2638	T2639	compound	cold,stress
R1657	T2639	T2637	pobj	stress,of
R1658	T2640	T2634	punct	", ",fasted
R1659	T2641	T2634	nsubjpass	mice,fasted
R1660	T2642	T2634	auxpass	were,fasted
R1661	T2643	T2634	prep	for,fasted
R1662	T2644	T2645	nummod	18,h
R1663	T2645	T2643	pobj	h,for
R1664	T2646	T2634	cc	and,fasted
R1665	T2647	T2634	conj	placed,fasted
R1666	T2648	T2647	prep	in,placed
R1667	T2649	T2650	nummod	4,°C
R1668	T2650	T2651	compound	°C,environment
R1669	T2651	T2648	pobj	environment,in
R1670	T2652	T2647	prep	for,placed
R1671	T2653	T2654	det	a,period
R1672	T2654	T2652	pobj	period,for
R1673	T2655	T2656	nummod	3,h
R1674	T2656	T2654	compound	h,period
R1675	T2657	T2656	punct	-,h
R1676	T2658	T2634	punct	.,fasted
R1677	T2660	T2661	det	The,mice
R1678	T2661	T2666	nsubjpass	mice,compromised
R1679	T2662	T2661	nmod	MCAD,mice
R1680	T2663	T2662	punct	−,MCAD
R1681	T2664	T2662	punct	/,MCAD
R1682	T2665	T2662	punct	−,MCAD
R1683	T2667	T2666	auxpass	were,compromised
R1684	T2668	T2666	advmod	significantly,compromised
R1685	T2669	T2666	prep	within,compromised
R1686	T2670	T2671	det	this,period
R1687	T2671	T2669	pobj	period,within
R1688	T2672	T2671	amod	short,period
R1689	T2673	T2671	prep	of,period
R1690	T2674	T2675	compound	cold,stress
R1691	T2675	T2673	pobj	stress,of
R1692	T2676	T2666	punct	", ",compromised
R1693	T2677	T2678	nsubj	some,severe
R1694	T2678	T2666	amod	severe,compromised
R1695	T2679	T2678	advmod	enough,severe
R1696	T2680	T2681	aux	to,result
R1697	T2681	T2678	xcomp	result,severe
R1698	T2682	T2681	prep	in,result
R1699	T2683	T2682	pobj	fatalities,in
R1700	T2684	T2666	punct	.,compromised
R1701	T2686	T2687	prep	After,was
R1702	T2688	T2689	nummod	1,h
R1703	T2689	T2686	pobj	h,After
R1704	T2690	T2689	prep	of,h
R1705	T2691	T2692	det	the,challenge
R1706	T2692	T2690	pobj	challenge,of
R1707	T2693	T2692	compound	cold,challenge
R1708	T2694	T2687	punct	", ",was
R1709	T2695	T2696	det	the,temperature
R1710	T2696	T2687	nsubj	temperature,was
R1711	T2697	T2696	amod	average,temperature
R1712	T2698	T2696	amod	rectal,temperature
R1713	T2699	T2696	prep	of,temperature
R1714	T2700	T2701	nmod	MCAD,mice
R1715	T2701	T2699	pobj	mice,of
R1716	T2702	T2700	punct	−,MCAD
R1717	T2703	T2700	punct	/,MCAD
R1718	T2704	T2700	punct	−,MCAD
R1719	T2705	T2706	punct	(,5
R1720	T2706	T2701	parataxis	5,mice
R1721	T2707	T2706	nsubj	n,5
R1722	T2708	T2706	punct	=,5
R1723	T2709	T2706	punct	),5
R1724	T2710	T2711	nummod	23.4,°C
R1725	T2711	T2687	attr	°C,was
R1726	T2712	T2713	mark	as,compared
R1727	T2713	T2687	advcl	compared,was
R1728	T2714	T2713	prep	with,compared
R1729	T2715	T2716	nummod	35,°C
R1730	T2716	T2714	pobj	°C,with
R1731	T2717	T2716	prep	for,°C
R1732	T2718	T2719	nmod	MCAD,mice
R1733	T2719	T2717	pobj	mice,for
R1734	T2720	T2718	punct	+,MCAD
R1735	T2721	T2718	punct	/,MCAD
R1736	T2722	T2718	punct	+,MCAD
R1737	T2723	T2724	punct	(,4
R1738	T2724	T2719	parataxis	4,mice
R1739	T2725	T2724	nsubj	n,4
R1740	T2726	T2724	punct	=,4
R1741	T2727	T2724	punct	),4
R1742	T2728	T2687	punct	.,was
R1743	T2730	T2731	amod	Rectal,temperatures
R1744	T2731	T2732	nsubj	temperatures,declined
R1745	T2733	T2732	prep	to,declined
R1746	T2734	T2735	amod	unrecoverable,temperatures
R1747	T2735	T2733	pobj	temperatures,to
R1748	T2736	T2735	prep	of,temperatures
R1749	T2737	T2738	quantmod	16.7,19.2
R1750	T2738	T2740	nummod	19.2,°C
R1751	T2739	T2738	punct	–,19.2
R1752	T2740	T2736	pobj	°C,of
R1753	T2741	T2732	prep	in,declined
R1754	T2742	T2743	quantmod	three,five
R1755	T2743	T2746	nummod	five,mice
R1756	T2744	T2743	quantmod	of,five
R1757	T2745	T2743	quantmod	the,five
R1758	T2746	T2741	pobj	mice,in
R1759	T2747	T2746	nmod	MCAD,mice
R1760	T2748	T2747	punct	−,MCAD
R1761	T2749	T2747	punct	/,MCAD
R1762	T2750	T2747	punct	−,MCAD
R1763	T2751	T2732	punct	.,declined
R1764	T2753	T2754	prep	By,averaged
R1765	T2755	T2756	det	the,end
R1766	T2756	T2753	pobj	end,By
R1767	T2757	T2756	prep	of,end
R1768	T2758	T2759	det	the,mark
R1769	T2759	T2757	pobj	mark,of
R1770	T2760	T2761	nummod	1.5,h
R1771	T2761	T2759	compound	h,mark
R1772	T2762	T2761	punct	-,h
R1773	T2763	T2754	punct	", ",averaged
R1774	T2764	T2765	det	the,mice
R1775	T2765	T2754	nsubj	mice,averaged
R1776	T2766	T2765	nummod	two,mice
R1777	T2767	T2765	amod	surviving,mice
R1778	T2768	T2765	nmod	MCAD,mice
R1779	T2769	T2768	punct	−,MCAD
R1780	T2770	T2768	punct	/,MCAD
R1781	T2771	T2768	punct	−,MCAD
R1782	T2772	T2773	nummod	22.7,°C
R1783	T2773	T2754	dobj	°C,averaged
R1784	T2774	T2754	punct	.,averaged
R1785	T2776	T2777	prep	In,survived
R1786	T2778	T2776	pobj	contrast,In
R1787	T2779	T2777	punct	", ",survived
R1788	T2780	T2781	det	all,mice
R1789	T2781	T2777	nsubj	mice,survived
R1790	T2782	T2781	nummod	four,mice
R1791	T2783	T2781	nmod	MCAD,mice
R1792	T2784	T2783	punct	+,MCAD
R1793	T2785	T2783	punct	/,MCAD
R1794	T2786	T2783	punct	+,MCAD
R1795	T2787	T2788	det	the,stress
R1796	T2788	T2777	dobj	stress,survived
R1797	T2789	T2790	nummod	3,h
R1798	T2790	T2788	compound	h,stress
R1799	T2791	T2790	punct	-,h
R1800	T2792	T2788	compound	cold,stress
R1801	T2793	T2777	punct	", ",survived
R1802	T2794	T2777	advcl	ending,survived
R1803	T2795	T2794	prep	with,ending
R1804	T2796	T2797	det	an,temperature
R1805	T2797	T2795	pobj	temperature,with
R1806	T2798	T2797	amod	average,temperature
R1807	T2799	T2797	amod	rectal,temperature
R1808	T2800	T2797	prep	of,temperature
R1809	T2801	T2802	nummod	33.6,°C
R1810	T2802	T2800	pobj	°C,of
R1811	T2803	T2777	punct	.,survived
R1812	T2908	T2909	amod	Organic,Acid
R1813	T2910	T2909	cc	and,Acid
R1814	T2911	T2912	compound	Acylcarnitine,Analysis
R1815	T2912	T2909	conj	Analysis,Acid
R1816	T2914	T2915	nmod	Urine,acid
R1817	T2915	T2917	compound	acid,analysis
R1818	T2916	T2915	amod	organic,acid
R1819	T2917	T2918	nsubj	analysis,revealed
R1820	T2919	T2920	mark	that,developed
R1821	T2920	T2918	ccomp	developed,revealed
R1822	T2921	T2922	nmod	MCAD,mice
R1823	T2922	T2920	nsubj	mice,developed
R1824	T2923	T2921	punct	−,MCAD
R1825	T2924	T2921	punct	/,MCAD
R1826	T2925	T2921	punct	−,MCAD
R1827	T2926	T2927	det	an,profile
R1828	T2927	T2920	dobj	profile,developed
R1829	T2928	T2929	amod	organic,acid
R1830	T2929	T2927	compound	acid,profile
R1831	T2930	T2927	amod	similar,profile
R1832	T2931	T2930	prep	to,similar
R1833	T2932	T2933	npadvmod	MCAD,deficient
R1834	T2933	T2935	amod	deficient,patients
R1835	T2934	T2933	punct	-,deficient
R1836	T2935	T2931	pobj	patients,to
R1837	T2936	T2935	amod	human,patients
R1838	T2937	T2918	punct	.,revealed
R1839	T2939	T2940	advmod	Specifically,developed
R1840	T2941	T2940	punct	", ",developed
R1841	T2942	T2943	advmod	when,fasted
R1842	T2943	T2940	advcl	fasted,developed
R1843	T2944	T2943	prep	for,fasted
R1844	T2945	T2946	nummod	18,h
R1845	T2946	T2944	pobj	h,for
R1846	T2947	T2940	punct	", ",developed
R1847	T2948	T2949	nmod	MCAD,mice
R1848	T2949	T2940	nsubj	mice,developed
R1849	T2950	T2948	punct	−,MCAD
R1850	T2951	T2948	punct	/,MCAD
R1851	T2952	T2948	punct	−,MCAD
R1852	T2953	T2954	advmod	significantly,elevated
R1853	T2954	T2955	amod	elevated,concentrations
R1854	T2955	T2940	dobj	concentrations,developed
R1855	T2956	T2955	prep	of,concentrations
R1856	T2957	T2958	amod	adipic,acids
R1857	T2958	T2956	pobj	acids,of
R1858	T2959	T2957	punct	", ",adipic
R1859	T2960	T2957	conj	suberic,adipic
R1860	T2961	T2960	punct	", ",suberic
R1861	T2962	T2960	cc	and,suberic
R1862	T2963	T2960	conj	sebacic,suberic
R1863	T2964	T2958	cc	and,acids
R1864	T2965	T2958	conj	hexanoylglycine,acids
R1865	T2966	T2967	mark	as,compared
R1866	T2967	T2940	advcl	compared,developed
R1867	T2968	T2967	prep	to,compared
R1868	T2969	T2970	nmod	MCAD,controls
R1869	T2970	T2968	pobj	controls,to
R1870	T2971	T2969	punct	+,MCAD
R1871	T2972	T2969	punct	/,MCAD
R1872	T2973	T2969	punct	+,MCAD
R1873	T2974	T2970	punct	", ",controls
R1874	T2975	T2976	dep	which,showed
R1875	T2976	T2970	relcl	showed,controls
R1876	T2977	T2976	dobj	trace,showed
R1877	T2978	T2977	prep	to,trace
R1878	T2979	T2980	det	no,amounts
R1879	T2980	T2978	pobj	amounts,to
R1880	T2981	T2980	amod	detectable,amounts
R1881	T2982	T2977	prep	of,trace
R1882	T2983	T2984	det	the,acids
R1883	T2984	T2982	pobj	acids,of
R1884	T2985	T2984	amod	same,acids
R1885	T2986	T2984	amod	organic,acids
R1886	T2987	T2988	punct	(,Table
R1887	T2988	T2940	parataxis	Table,developed
R1888	T2989	T2988	nummod	1,Table
R1889	T2990	T2988	punct	),Table
R1890	T2991	T2940	punct	.,developed
R1891	T2993	T2994	amod	Adipic,acid
R1892	T2994	T2995	nsubj	acid,is
R1893	T2996	T2995	neg	not,is
R1894	T2997	T2995	acomp	specific,is
R1895	T2998	T2997	prep	to,specific
R1896	T2999	T3000	compound	MCAD,deficiency
R1897	T3000	T2998	pobj	deficiency,to
R1898	T3001	T2995	punct	.,is
R1899	T3003	T3004	nsubj	We,evaluated
R1900	T3005	T3004	advmod	also,evaluated
R1901	T3006	T3007	npadvmod	β,hydroxybutyric
R1902	T3007	T3009	amod	hydroxybutyric,concentrations
R1903	T3008	T3007	punct	-,hydroxybutyric
R1904	T3009	T3004	dobj	concentrations,evaluated
R1905	T3010	T3007	cc	and,hydroxybutyric
R1906	T3011	T3007	conj	acetoacetic,hydroxybutyric
R1907	T3012	T3004	cc	and,evaluated
R1908	T3013	T3004	conj	found,evaluated
R1909	T3014	T3015	det	no,differences
R1910	T3015	T3013	dobj	differences,found
R1911	T3016	T3015	amod	significant,differences
R1912	T3017	T3015	prep	between,differences
R1913	T3018	T3019	compound	MCAD,genotypes
R1914	T3019	T3017	pobj	genotypes,between
R1915	T3020	T3021	punct	(,shown
R1916	T3021	T3013	parataxis	shown,found
R1917	T3022	T3021	nsubj	data,shown
R1918	T3023	T3021	neg	not,shown
R1919	T3024	T3021	punct	),shown
R1920	T3025	T3004	punct	.,evaluated
R1921	T3027	T3028	nsubj	Comparison,revealed
R1922	T3029	T3027	prep	of,Comparison
R1923	T3030	T3031	nmod	MCAD,mice
R1924	T3031	T3029	pobj	mice,of
R1925	T3032	T3030	punct	+,MCAD
R1926	T3033	T3030	punct	/,MCAD
R1927	T3034	T3030	punct	+,MCAD
R1928	T3035	T3030	cc	and,MCAD
R1929	T3036	T3030	conj	MCAD,MCAD
R1930	T3037	T3036	punct	−,MCAD
R1931	T3038	T3036	punct	/,MCAD
R1932	T3039	T3036	punct	−,MCAD
R1933	T3040	T3041	det	no,differences
R1934	T3041	T3028	dobj	differences,revealed
R1935	T3042	T3041	amod	significant,differences
R1936	T3043	T3041	prep	in,differences
R1937	T3044	T3045	amod	total,concentrations
R1938	T3045	T3043	pobj	concentrations,in
R1939	T3046	T3045	compound	serum,concentrations
R1940	T3047	T3045	compound	carnitine,concentrations
R1941	T3048	T3041	prep	between,differences
R1942	T3049	T3050	nmod	MCAD,mice
R1943	T3050	T3048	pobj	mice,between
R1944	T3051	T3049	punct	+,MCAD
R1945	T3052	T3049	punct	/,MCAD
R1946	T3053	T3049	punct	+,MCAD
R1947	T3054	T3049	cc	and,MCAD
R1948	T3055	T3049	conj	MCAD,MCAD
R1949	T3056	T3055	punct	−,MCAD
R1950	T3057	T3055	punct	/,MCAD
R1951	T3058	T3055	punct	−,MCAD
R1952	T3059	T3028	punct	", ",revealed
R1953	T3060	T3028	cc	but,revealed
R1954	T3061	T3062	nmod	MCAD,mice
R1955	T3062	T3066	nsubj	mice,had
R1956	T3063	T3061	punct	−,MCAD
R1957	T3064	T3061	punct	/,MCAD
R1958	T3065	T3061	punct	−,MCAD
R1959	T3066	T3028	conj	had,revealed
R1960	T3067	T3068	det	a,elevation
R1961	T3068	T3075	nsubj	elevation,evident
R1962	T3069	T3070	quantmod	5,6
R1963	T3070	T3073	quantmod	6,fold
R1964	T3071	T3070	punct	-,6
R1965	T3072	T3070	quantmod	to,6
R1966	T3073	T3068	nummod	fold,elevation
R1967	T3074	T3073	punct	-,fold
R1968	T3075	T3066	ccomp	evident,had
R1969	T3076	T3068	prep	of,elevation
R1970	T3077	T3078	compound	serum,decenoylcarnitine
R1971	T3078	T3076	pobj	decenoylcarnitine,of
R1972	T3079	T3075	prep	in,evident
R1973	T3080	T3081	det	the,profile
R1974	T3081	T3079	pobj	profile,in
R1975	T3082	T3081	compound	acylcarnitine,profile
R1976	T3083	T3084	punct	(,Figure
R1977	T3084	T3066	parataxis	Figure,had
R1978	T3085	T3084	nummod	4A,Figure
R1979	T3086	T3084	punct	),Figure
R1980	T3087	T3066	punct	.,had
R1981	T3089	T3090	compound	Bile,acylcarnitine
R1982	T3090	T3091	compound	acylcarnitine,analysis
R1983	T3091	T3092	nsubj	analysis,revealed
R1984	T3093	T3094	det	a,pattern
R1985	T3094	T3092	dobj	pattern,revealed
R1986	T3095	T3094	amod	similar,pattern
R1987	T3096	T3094	compound	acylcarnitine,pattern
R1988	T3097	T3094	prep	as,pattern
R1989	T3098	T3097	prep	in,as
R1990	T3099	T3098	pobj	serum,in
R1991	T3100	T3101	punct	(,Figure
R1992	T3101	T3092	parataxis	Figure,revealed
R1993	T3102	T3101	nummod	4B,Figure
R1994	T3103	T3101	punct	),Figure
R1995	T3104	T3092	punct	.,revealed
R1996	T3106	T3107	advmod	However,are
R1997	T3108	T3107	punct	", ",are
R1998	T3109	T3110	det	the,profiles
R1999	T3110	T3107	nsubj	profiles,are
R2000	T3111	T3110	compound	acylcarnitine,profiles
R2001	T3112	T3110	prep	of,profiles
R2002	T3113	T3114	det	the,mice
R2003	T3114	T3112	pobj	mice,of
R2004	T3115	T3114	nmod	MCAD,mice
R2005	T3116	T3115	punct	−,MCAD
R2006	T3117	T3115	punct	/,MCAD
R2007	T3118	T3115	punct	−,MCAD
R2008	T3119	T3107	acomp	different,are
R2009	T3120	T3119	prep	from,different
R2010	T3121	T3120	pobj	those,from
R2011	T3122	T3121	prep	of,those
R2012	T3123	T3124	amod	human,patients
R2013	T3124	T3122	pobj	patients,of
R2014	T3125	T3126	npadvmod	MCAD,deficient
R2015	T3126	T3124	amod	deficient,patients
R2016	T3127	T3126	punct	-,deficient
R2017	T3128	T3129	punct	(,Figure
R2018	T3129	T3107	parataxis	Figure,are
R2019	T3130	T3129	nummod	4C,Figure
R2020	T3131	T3129	punct	),Figure
R2021	T3132	T3107	punct	.,are
R2022	T3134	T3135	amod	Human,patients
R2023	T3135	T3136	nsubj	patients,present
R2024	T3136	T3137	ccomp	present,was
R2025	T3138	T3136	prep	with,present
R2026	T3139	T3140	amod	elevated,levels
R2027	T3140	T3138	pobj	levels,with
R2028	T3141	T3140	prep	of,levels
R2029	T3142	T3141	pobj	C6,of
R2030	T3143	T3142	punct	", ",C6
R2031	T3144	T3142	conj	C8,C6
R2032	T3145	T3144	punct	", ",C8
R2033	T3146	T3144	cc	and,C8
R2034	T3147	T3144	conj	C10,C8
R2035	T3148	T3147	punct	:,C10
R2036	T3149	T3147	nummod	1,C10
R2037	T3150	T3142	appos	acylcarnitines,C6
R2038	T3151	T3136	punct	", ",present
R2039	T3152	T3153	mark	as,did
R2040	T3153	T3136	advcl	did,present
R2041	T3154	T3155	det	the,mice
R2042	T3155	T3153	nsubj	mice,did
R2043	T3156	T3155	compound	mutant,mice
R2044	T3157	T3137	punct	;,was
R2045	T3158	T3137	advmod	however,was
R2046	T3159	T3137	punct	", ",was
R2047	T3160	T3161	det	the,peak
R2048	T3161	T3137	nsubj	peak,was
R2049	T3162	T3161	amod	predominant,peak
R2050	T3163	T3164	compound	C8,acylcarnitine
R2051	T3164	T3137	attr	acylcarnitine,was
R2052	T3165	T3137	prep	in,was
R2053	T3166	T3165	pobj	humans,in
R2054	T3167	T3137	punct	", ",was
R2055	T3168	T3169	mark	whereas,was
R2056	T3169	T3137	advcl	was,was
R2057	T3170	T3169	prep	in,was
R2058	T3171	T3172	det	the,mouse
R2059	T3172	T3170	pobj	mouse,in
R2060	T3173	T3169	nsubj	it,was
R2061	T3174	T3175	nmod	C10,acylcarnitine
R2062	T3175	T3169	attr	acylcarnitine,was
R2063	T3176	T3174	punct	:,C10
R2064	T3177	T3174	nummod	1,C10
R2065	T3178	T3137	punct	.,was
R2070	T3319	T3320	amod	Complete,examination
R2071	T3320	T3322	nsubj	examination,demonstrated
R2072	T3321	T3320	amod	histopathologic,examination
R2073	T3323	T3320	prep	of,examination
R2074	T3324	T3325	nummod	one,group
R2075	T3325	T3323	pobj	group,of
R2076	T3326	T3325	prep	of,group
R2077	T3327	T3328	nmod	mutant,mice
R2078	T3328	T3326	pobj	mice,of
R2079	T3329	T3327	cc	and,mutant
R2080	T3330	T3327	conj	MCAD,mutant
R2081	T3331	T3330	punct	+,MCAD
R2082	T3332	T3330	punct	/,MCAD
R2083	T3333	T3330	punct	+,MCAD
R2084	T3334	T3328	compound	control,mice
R2085	T3335	T3320	prep	after,examination
R2086	T3336	T3337	det	a,fast
R2087	T3337	T3335	pobj	fast,after
R2088	T3338	T3339	nummod	24,h
R2089	T3339	T3337	compound	h,fast
R2090	T3340	T3339	punct	-,h
R2091	T3341	T3342	amod	diffuse,steatosis
R2092	T3342	T3322	dobj	steatosis,demonstrated
R2093	T3343	T3342	amod	microvesicular,steatosis
R2094	T3344	T3343	cc	and,microvesicular
R2095	T3345	T3343	conj	macrovesicular,microvesicular
R2096	T3346	T3342	amod	hepatic,steatosis
R2097	T3347	T3322	prep	in,demonstrated
R2098	T3348	T3349	quantmod	6,8
R2099	T3349	T3351	nummod	8,wk
R2100	T3350	T3349	punct	–,8
R2101	T3351	T3353	npadvmod	wk,old
R2102	T3352	T3351	punct	-,wk
R2103	T3353	T3355	amod	old,mice
R2104	T3354	T3353	punct	-,old
R2105	T3355	T3347	pobj	mice,in
R2106	T3356	T3355	nmod	MCAD,mice
R2107	T3357	T3356	punct	−,MCAD
R2108	T3358	T3356	punct	/,MCAD
R2109	T3359	T3356	punct	−,MCAD
R2110	T3360	T3361	mark	whereas,had
R2111	T3361	T3322	advcl	had,demonstrated
R2112	T3362	T3363	nmod	MCAD,mice
R2113	T3363	T3361	nsubj	mice,had
R2114	T3364	T3362	punct	+,MCAD
R2115	T3365	T3362	punct	/,MCAD
R2116	T3366	T3362	punct	+,MCAD
R2117	T3367	T3368	det	no,changes
R2118	T3368	T3361	dobj	changes,had
R2119	T3369	T3368	amod	histologic,changes
R2120	T3370	T3371	punct	(,5A
R2121	T3371	T3322	parataxis	5A,demonstrated
R2122	T3372	T3371	nmod	Figure,5A
R2123	T3373	T3371	cc	and,5A
R2124	T3374	T3371	conj	5B,5A
R2125	T3375	T3371	punct	),5A
R2126	T3376	T3322	punct	.,demonstrated
R2127	T3378	T3379	prep	In,were
R2128	T3380	T3381	det	another,group
R2129	T3381	T3378	pobj	group,In
R2130	T3382	T3381	prep	of,group
R2131	T3383	T3384	nummod	4,wk
R2132	T3384	T3386	npadvmod	wk,old
R2133	T3385	T3384	punct	-,wk
R2134	T3386	T3388	amod	old,mice
R2135	T3387	T3386	punct	-,old
R2136	T3388	T3382	pobj	mice,of
R2137	T3389	T3388	nmod	MCAD,mice
R2138	T3390	T3389	punct	+,MCAD
R2139	T3391	T3389	punct	/,MCAD
R2140	T3392	T3389	punct	+,MCAD
R2141	T3393	T3389	cc	and,MCAD
R2142	T3394	T3389	conj	MCAD,MCAD
R2143	T3395	T3394	punct	−,MCAD
R2144	T3396	T3394	punct	/,MCAD
R2145	T3397	T3394	punct	−,MCAD
R2146	T3398	T3388	acl	fasted,mice
R2147	T3399	T3398	prep	for,fasted
R2148	T3400	T3401	nummod	24,h
R2187	T3443	T3442	punct	−,MCAD
R2188	T3444	T3442	punct	/,MCAD
R2189	T3445	T3442	punct	−,MCAD
R2190	T3446	T3432	punct	.,found
R2211	T3469	T3470	punct	(,5C
R2212	T3470	T3449	parataxis	5C,had
R2213	T3471	T3470	nmod	Figure,5C
R2214	T3472	T3470	cc	and,5C
R2215	T3473	T3470	conj	5D,5C
R2216	T3474	T3470	punct	),5C
R2217	T3475	T3449	punct	.,had
R2218	T3477	T3478	nsubj	Changes,included
R2219	T3479	T3477	prep	in,Changes
R2220	T3480	T3481	amod	degenerating,myocytes
R2221	T3481	T3479	pobj	myocytes,in
R2222	T3482	T3478	dobj	swelling,included
R2223	T3483	T3482	punct	", ",swelling
R2224	T3484	T3485	amod	pale,staining
R2225	T3485	T3482	conj	staining,swelling
R2226	T3486	T3485	punct	", ",staining
R2227	T3487	T3485	cc	and,staining
R2228	T3488	T3485	punct	", ",staining
R2229	T3489	T3490	prep	in,replacement
R2230	T3490	T3485	conj	replacement,staining
R2231	T3491	T3489	pobj	portions,in
R2232	T3492	T3491	prep	of,portions
R2233	T3493	T3494	det	the,sarcoplasm
R2234	T3494	T3492	pobj	sarcoplasm,of
R2235	T3495	T3490	punct	", ",replacement
R2236	T3496	T3490	prep	of,replacement
R2237	T3497	T3496	pobj	myofibrils,of
R2238	T3498	T3490	prep	with,replacement
R2239	T3499	T3500	advmod	finely,granular
R2240	T3500	T3501	amod	granular,material
R2241	T3501	T3498	pobj	material,with
R2242	T3502	T3501	amod	eosinophilic,material
R2243	T3503	T3478	punct	.,included
R2244	T3505	T3506	nsubj	Nuclei,were
R2245	T3507	T3505	prep	of,Nuclei
R2246	T3508	T3509	amod	affected,myocytes
R2247	T3509	T3507	pobj	myocytes,of
R2248	T3510	T3506	acomp	large,were
R2249	T3511	T3510	punct	", ",large
R2250	T3512	T3510	conj	pale,large
R2251	T3513	T3512	punct	", ",pale
R2252	T3514	T3512	cc	and,pale
R2253	T3515	T3512	conj	vesicular,pale
R2254	T3516	T3506	cc	and,were
R2255	T3517	T3506	conj	had,were
R2256	T3518	T3519	amod	prominent,nucleoli
R2257	T3519	T3517	dobj	nucleoli,had
R2258	T3520	T3506	punct	.,were
R2259	T3522	T3523	prep	In,was
R2260	T3524	T3525	det	the,areas
R2261	T3525	T3522	pobj	areas,In
R2262	T3526	T3527	advmod	most,severely
R2263	T3527	T3528	advmod	severely,affected
R2264	T3528	T3525	amod	affected,areas
R2265	T3529	T3523	punct	", ",was
R2266	T3530	T3523	expl	there,was
R2267	T3531	T3523	attr	loss,was
R2268	T3532	T3531	prep	of,loss
R2269	T3533	T3532	pobj	myocytes,of
R2270	T3534	T3531	acl	accompanied,loss
R2271	T3535	T3534	agent	by,accompanied
R2272	T3536	T3535	pobj	fibrosis,by
R2273	T3537	T3523	punct	.,was
R2274	T3539	T3540	prep	In,was
R2275	T3541	T3542	det	the,wall
R2276	T3542	T3539	pobj	wall,In
R2277	T3543	T3542	prep	of,wall
R2278	T3544	T3545	det	the,aorta
R2279	T3545	T3543	pobj	aorta,of
R2280	T3546	T3545	prep	at,aorta
R2281	T3547	T3548	det	the,base
R2282	T3548	T3546	pobj	base,at
R2283	T3549	T3548	prep	of,base
R2284	T3550	T3551	det	the,heart
R2285	T3551	T3549	pobj	heart,of
R2286	T3552	T3540	expl	there,was
R2287	T3553	T3554	amod	multifocal,degeneration
R2288	T3554	T3540	attr	degeneration,was
R2289	T3555	T3554	prep	of,degeneration
R2290	T3556	T3557	det	the,tissue
R2291	T3557	T3555	pobj	tissue,of
R2292	T3558	T3557	amod	elastic,tissue
R2293	T3559	T3554	punct	", ",degeneration
R2294	T3560	T3554	acl	accompanied,degeneration
R2295	T3561	T3560	agent	by,accompanied
R2296	T3562	T3563	amod	multifocal,collections
R2297	T3563	T3561	pobj	collections,by
R2298	T3564	T3563	prep	of,collections
R2299	T3565	T3566	amod	globular,pigment
R2300	T3566	T3564	pobj	pigment,of
R2301	T3567	T3566	amod	translucent,pigment
R2302	T3568	T3569	amod	yellow,brown
R2303	T3569	T3566	amod	brown,pigment
R2304	T3570	T3569	punct	-,brown
R2305	T3571	T3563	acl	interpreted,collections
R2306	T3572	T3573	aux	to,be
R2307	T3573	T3571	xcomp	be,interpreted
R2308	T3574	T3575	compound	ceroid,lipofuscin
R2309	T3575	T3573	attr	lipofuscin,be
R2310	T3576	T3575	punct	/,lipofuscin
R2311	T3577	T3540	punct	.,was
R2312	T3579	T3580	amod	Similar,deposits
R2313	T3580	T3581	nsubjpass	deposits,scattered
R2314	T3582	T3581	auxpass	were,scattered
R2315	T3583	T3581	prep	within,scattered
R2316	T3584	T3585	amod	adjacent,tissue
R2317	T3585	T3583	pobj	tissue,within
R2318	T3586	T3585	compound	adipose,tissue
R2319	T3587	T3581	punct	.,scattered
R4678	T7248	T7247	prep	for,Strategy
R4679	T7249	T7248	pobj	Disruption,for
R4680	T7250	T7249	prep	of,Disruption
R4681	T7251	T7252	det	the,Gene
R4682	T7252	T7250	pobj	Gene,of
R4683	T7253	T7252	compound	Mouse,Gene
R4684	T7254	T7252	compound	Acadm,Gene
R4685	T7256	T7257	punct	(,A
R4686	T7257	T7258	meta	A,vector
R4687	T7259	T7257	punct	),A
R4688	T7260	T7258	det	The,vector
R4689	T7261	T7262	compound	MCAD,insertion
R4690	T7262	T7258	compound	insertion,vector
R4691	T7263	T7262	compound	IV2,insertion
R4692	T7264	T7258	compound	targeting,vector
R4693	T7265	T7258	prep	with,vector
R4694	T7266	T7267	det	a,region
R4695	T7267	T7265	pobj	region,with
R4696	T7268	T7267	amod	deleted,region
R4697	T7269	T7270	nummod	1.3,kb
R4698	T7270	T7267	compound	kb,region
R4699	T7271	T7270	punct	-,kb
R4700	T7272	T7267	acl	encompassing,region
R4701	T7273	T7272	dobj	exon,encompassing
R4702	T7274	T7273	nummod	10,exon
R4703	T7275	T7273	cc	and,exon
R4704	T7276	T7277	amod	flanking,sequences
R4705	T7277	T7273	conj	sequences,exon
R4706	T7278	T7258	punct	.,vector
R4707	T7280	T7281	compound	MCAD,IV2
R4708	T7281	T7282	nsubj	IV2,undergoes
R4709	T7283	T7284	compound	gap,repair
R4710	T7284	T7282	dobj	repair,undergoes
R4711	T7285	T7282	prep	upon,undergoes
R4712	T7286	T7287	amod	homologous,recombination
R4713	T7287	T7285	pobj	recombination,upon
R4714	T7288	T7282	prep	at,undergoes
R4715	T7289	T7290	det	the,locus
R4716	T7290	T7288	pobj	locus,at
R4717	T7291	T7290	amod	endogenous,locus
R4718	T7292	T7290	compound	Acadm,locus
R4719	T7293	T7282	advcl	resulting,undergoes
R4720	T7294	T7293	prep	in,resulting
R4721	T7295	T7296	det	a,duplication
R4722	T7296	T7294	pobj	duplication,in
R4723	T7297	T7296	prep	of,duplication
R4724	T7298	T7299	nmod	exons,8
R4725	T7299	T7297	pobj	8,of
R4726	T7300	T7299	punct	", ",8
R4727	T7301	T7299	conj	9,8
R4728	T7302	T7301	punct	", ",9
R4729	T7303	T7301	cc	and,9
R4730	T7304	T7301	conj	10,9
R4731	T7305	T7296	prep	at,duplication
R4732	T7306	T7307	det	the,allele
R4733	T7307	T7305	pobj	allele,at
R4734	T7308	T7307	amod	disrupted,allele
R4735	T7309	T7282	punct	.,undergoes
R4736	T7311	T7312	punct	(,B
R4737	T7312	T7313	meta	B,analysis
R4738	T7314	T7312	punct	),B
R4739	T7315	T7316	compound	Southern,blot
R4740	T7316	T7313	compound	blot,analysis
R4741	T7317	T7313	prep	of,analysis
R4742	T7318	T7319	npadvmod	EcoRI,digested
R4743	T7319	T7321	amod	digested,DNA
R4744	T7320	T7319	punct	-,digested
R4745	T7321	T7317	pobj	DNA,of
R4746	T7322	T7321	amod	genomic,DNA
R4747	T7323	T7321	prep	from,DNA
R4748	T7324	T7325	compound	ES,cells
R4749	T7325	T7323	pobj	cells,from
R4750	T7326	T7325	acl	screened,cells
R4751	T7327	T7326	prep	by,screened
R4752	T7328	T7327	pobj	PCR,by
R4753	T7329	T7313	punct	.,analysis
R4754	T7331	T7332	compound	Probe,A
R4755	T7332	T7333	nsubj	A,hybridizes
R4756	T7334	T7332	punct	", ",A
R4757	T7335	T7336	det	a,fragment
R4758	T7336	T7332	appos	fragment,A
R4759	T7337	T7336	compound	DNA,fragment
R4760	T7338	T7336	acl	consisting,fragment
R4761	T7339	T7338	prep	of,consisting
R4762	T7340	T7341	det	a,portion
R4763	T7341	T7339	pobj	portion,of
R4764	T7342	T7341	prep	of,portion
R4765	T7343	T7342	pobj	exon,of
R4766	T7344	T7343	nummod	10,exon
R4767	T7345	T7346	dep	that,is
R4768	T7346	T7341	relcl	is,portion
R4769	T7347	T7346	neg	not,is
R4770	T7348	T7346	acomp	present,is
R4771	T7349	T7346	prep	in,is
R4772	T7350	T7351	det	the,vector
R4773	T7351	T7349	pobj	vector,in
R4774	T7352	T7351	compound	targeting,vector
R4775	T7353	T7333	punct	", ",hybridizes
R4776	T7354	T7333	prep	to,hybridizes
R4777	T7355	T7356	det	an,fragment
R4778	T7356	T7354	pobj	fragment,to
R4779	T7357	T7356	amod	endogenous,fragment
R4780	T7358	T7359	nummod	3.1,kb
R4781	T7359	T7356	compound	kb,fragment
R4782	T7360	T7359	punct	-,kb
R4783	T7361	T7333	cc	and,hybridizes
R4784	T7362	T7333	punct	", ",hybridizes
R4785	T7363	T7364	prep	upon,to
R4786	T7364	T7333	conj	to,hybridizes
R4787	T7365	T7366	amod	homologous,recombination
R4788	T7366	T7363	pobj	recombination,upon
R4789	T7367	T7364	punct	", ",to
R4790	T7368	T7369	det	a,fragment
R4791	T7369	T7364	pobj	fragment,to
R4792	T7370	T7371	nummod	13.2,kb
R4793	T7371	T7369	compound	kb,fragment
R4794	T7372	T7371	punct	-,kb
R4795	T7373	T7333	punct	.,hybridizes
R4796	T7375	T7376	nsubj	Lane,represents
R4797	T7377	T7375	nummod	1,Lane
R4798	T7378	T7379	det	a,line
R4799	T7379	T7376	dobj	line,represents
R4800	T7380	T7381	amod	wild,type
R4801	T7381	T7379	compound	type,line
R4802	T7382	T7381	punct	-,type
R4803	T7383	T7379	compound	ES,line
R4804	T7384	T7379	compound	cell,line
R4805	T7385	T7376	punct	", ",represents
R4806	T7386	T7376	cc	and,represents
R4807	T7387	T7388	nmod	Lane,2
R4808	T7388	T7389	nsubj	2,represent
R4809	T7389	T7376	conj	represent,represents
R4810	T7390	T7388	cc	and,2
R4811	T7391	T7388	conj	3,2
R4812	T7392	T7393	amod	targeted,lines
R4813	T7393	T7389	dobj	lines,represent
R4814	T7394	T7393	compound	ES,lines
R4815	T7395	T7393	compound	cell,lines
R4816	T7396	T7389	punct	.,represent
R4817	T7455	T7456	compound	Northern,Blot
R4818	T7456	T7457	compound	Blot,Analysis
R4819	T7458	T7457	prep	from,Analysis
R4820	T7459	T7460	nmod	MCAD,Mice
R4821	T7460	T7458	pobj	Mice,from
R4822	T7461	T7459	punct	−,MCAD
R4823	T7462	T7459	punct	/,MCAD
R4824	T7463	T7459	punct	−,MCAD
R4825	T7464	T7465	punct	(,2
R4826	T7465	T7459	parataxis	2,MCAD
R4827	T7466	T7465	nsubj	n,2
R4828	T7467	T7465	punct	=,2
R4829	T7468	T7465	punct	),2
R4830	T7469	T7459	cc	and,MCAD
R4831	T7470	T7459	conj	MCAD,MCAD
R4832	T7471	T7470	punct	+,MCAD
R4833	T7472	T7470	punct	/,MCAD
R4834	T7473	T7470	punct	+,MCAD
R4835	T7474	T7475	punct	(,2
R4836	T7475	T7470	parataxis	2,MCAD
R4837	T7476	T7475	nsubj	n,2
R4838	T7477	T7475	punct	=,2
R4839	T7478	T7475	punct	),2
R4840	T7480	T7481	compound	Acadm,message
R4841	T7481	T7482	nsubjpass	message,detected
R4842	T7483	T7482	auxpass	was,detected
R4843	T7484	T7482	prep	from,detected
R4844	T7485	T7486	det	the,heart
R4845	T7486	T7484	pobj	heart,from
R4846	T7487	T7486	punct	", ",heart
R4847	T7488	T7486	conj	liver,heart
R4848	T7489	T7488	punct	", ",liver
R4849	T7490	T7491	amod	brown,fat
R4850	T7491	T7488	conj	fat,liver
R4851	T7492	T7491	punct	", ",fat
R4852	T7493	T7491	conj	brain,fat
R4853	T7494	T7493	punct	", ",brain
R4854	T7495	T7493	conj	kidney,brain
R4855	T7496	T7495	punct	", ",kidney
R4856	T7497	T7495	cc	and,kidney
R4857	T7498	T7495	conj	muscle,kidney
R4858	T7499	T7486	punct	(,heart
R4859	T7500	T7486	cc	and,heart
R4860	T7501	T7502	amod	white,fat
R4861	T7502	T7486	conj	fat,heart
R4862	T7503	T7502	cc	and,fat
R4863	T7504	T7502	conj	testes,fat
R4864	T7505	T7506	punct	", ",shown
R4865	T7506	T7486	parataxis	shown,heart
R4866	T7507	T7506	nsubj	data,shown
R4867	T7508	T7506	neg	not,shown
R4868	T7509	T7506	punct	),shown
R4869	T7510	T7486	prep	of,heart
R4870	T7511	T7512	amod	only,mice
R4871	T7512	T7510	pobj	mice,of
R4872	T7513	T7512	nmod	MCAD,mice
R4873	T7514	T7513	punct	+,MCAD
R4874	T7515	T7513	punct	/,MCAD
R4875	T7516	T7513	punct	+,MCAD
R4876	T7517	T7482	punct	.,detected
R4877	T7519	T7520	advmod	Most,expression
R4878	T7520	T7522	nsubj	expression,occurred
R4879	T7521	T7520	amod	robust,expression
R4880	T7523	T7522	prep	in,occurred
R4881	T7524	T7525	amod	brown,fat
R4882	T7525	T7523	pobj	fat,in
R4883	T7526	T7525	punct	", ",fat
R4884	T7527	T7525	conj	kidney,fat
R4885	T7528	T7527	punct	", ",kidney
R4886	T7529	T7527	conj	heart,kidney
R4887	T7530	T7529	punct	", ",heart
R4888	T7531	T7529	cc	and,heart
R4889	T7532	T7533	amod	skeletal,muscle
R4890	T7533	T7529	conj	muscle,heart
R4891	T7534	T7522	punct	.,occurred
R4892	T7536	T7537	nmod	MCAD,mice
R4893	T7537	T7541	nsubj	mice,had
R4894	T7538	T7536	punct	−,MCAD
R4895	T7539	T7536	punct	/,MCAD
R4896	T7540	T7536	punct	−,MCAD
R4897	T7542	T7543	det	no,message
R4898	T7543	T7541	dobj	message,had
R4899	T7544	T7543	amod	detectable,message
R4900	T7545	T7541	prep	in,had
R4901	T7546	T7547	det	all,tissues
R4902	T7547	T7545	pobj	tissues,in
R4903	T7548	T7547	acl	examined,tissues
R4904	T7549	T7541	punct	.,had
R4905	T7639	T7638	prep	of,Immunoblots
R4906	T7640	T7641	compound	Liver,Homogenates
R4907	T7641	T7639	pobj	Homogenates,of
R4908	T7642	T7638	prep	from,Immunoblots
R4909	T7643	T7644	nmod	MCAD,Mice
R4910	T7644	T7642	pobj	Mice,from
R4911	T7645	T7643	punct	+,MCAD
R4912	T7646	T7643	punct	/,MCAD
R4913	T7647	T7643	punct	+,MCAD
R4914	T7648	T7643	cc	and,MCAD
R4915	T7649	T7643	conj	MCAD,MCAD
R4916	T7650	T7649	punct	−,MCAD
R4917	T7651	T7649	punct	/,MCAD
R4918	T7652	T7649	punct	−,MCAD
R4919	T7654	T7655	nsubjpass	These,probed
R4920	T7656	T7655	auxpass	were,probed
R4921	T7657	T7655	prep	with,probed
R4922	T7658	T7659	amod	anti-MCAD,antibody
R4923	T7659	T7657	pobj	antibody,with
R4924	T7660	T7659	cc	or,antibody
R4925	T7661	T7662	amod	anti-SCAD,antibody
R4926	T7662	T7659	conj	antibody,antibody
R4927	T7663	T7655	punct	.,probed
R4928	T7665	T7666	amod	Homozygous,mice
R4929	T7666	T7671	nsubj	mice,had
R4930	T7667	T7666	nmod	MCAD,mice
R4931	T7668	T7667	punct	−,MCAD
R4932	T7669	T7667	punct	/,MCAD
R4933	T7670	T7667	punct	−,MCAD
R4934	T7672	T7673	det	no,protein
R4935	T7673	T7671	dobj	protein,had
R4936	T7674	T7673	amod	detectable,protein
R4937	T7675	T7673	compound	MCAD,protein
R4938	T7676	T7671	punct	.,had
R4939	T7678	T7679	compound	MCAD,protein
R4940	T7679	T7680	nsubj	protein,is
R4941	T7681	T7682	advmod	only,detectable
R4942	T7682	T7680	acomp	detectable,is
R4943	T7683	T7680	prep	under,is
R4944	T7684	T7685	det	the,lane
R4945	T7685	T7683	pobj	lane,under
R4946	T7686	T7685	nmod	MCAD,lane
R4947	T7687	T7688	npadvmod	protein,spiked
R4948	T7688	T7685	amod	spiked,lane
R4949	T7689	T7688	punct	–,spiked
R4950	T7690	T7691	punct	(,control
R4951	T7691	T7685	parataxis	control,lane
R4952	T7692	T7691	amod	positive,control
R4953	T7693	T7691	punct	),control
R4954	T7694	T7680	punct	.,is
R4955	T7696	T7697	prep	As,revealed
R4956	T7698	T7699	det	a,analysis
R4957	T7699	T7696	pobj	analysis,As
R4958	T7700	T7699	compound	control,analysis
R4959	T7701	T7697	punct	", ",revealed
R4960	T7702	T7703	compound	liver,homogenates
R4961	T7703	T7697	nsubj	homogenates,revealed
R4962	T7704	T7703	acl	probed,homogenates
R4963	T7705	T7704	prep	with,probed
R4964	T7706	T7707	amod	anti-SCAD,antibody
R4965	T7707	T7705	pobj	antibody,with
R4966	T7708	T7709	mark	that,was
R4967	T7709	T7697	ccomp	was,revealed
R4968	T7710	T7711	compound	SCAD,protein
R4969	T7711	T7709	nsubj	protein,was
R4970	T7712	T7709	acomp	present,was
R4971	T7713	T7709	prep	in,was
R4972	T7714	T7715	preconj	both,MCAD
R4973	T7715	T7716	nmod	MCAD,mice
R4974	T7716	T7713	pobj	mice,in
R4975	T7717	T7715	punct	+,MCAD
R4976	T7718	T7715	punct	/,MCAD
R4977	T7719	T7715	punct	+,MCAD
R4978	T7720	T7715	cc	and,MCAD
R4979	T7721	T7715	conj	MCAD,MCAD
R4980	T7722	T7721	punct	−,MCAD
R4981	T7723	T7721	punct	/,MCAD
R4982	T7724	T7721	punct	−,MCAD
R4983	T7725	T7697	punct	.,revealed
R4984	T7727	T7728	det	No,protein
R4985	T7728	T7733	nsubjpass	protein,detected
R4986	T7729	T7728	nmod	MCAD,protein
R4987	T7730	T7731	amod	positive,control
R4988	T7731	T7728	compound	control,protein
R4989	T7732	T7731	punct	-,control
R4990	T7734	T7733	auxpass	is,detected
R4991	T7735	T7733	prep	by,detected
R4992	T7736	T7737	amod	anti-SCAD,antibodies
R4993	T7737	T7735	pobj	antibodies,by
R4994	T7738	T7739	punct	(,lane
R4995	T7739	T7733	parataxis	lane,detected
R4996	T7740	T7739	compound	MCAD,lane
R4997	T7741	T7739	punct	),lane
R4998	T7742	T7733	punct	.,detected
R4999	T7745	T7744	punct	", ",mw
R5000	T7746	T7747	amod	molecular,standards
R5001	T7747	T7744	appos	standards,mw
R5002	T7748	T7747	compound	weight,standards
R5003	T7749	T7744	punct	.,mw
R5004	T7814	T7815	compound	Acylcarnitine,Analyses
R5005	T7817	T7818	punct	(,A
R5006	T7818	T7819	meta	A,analysis
R5007	T7820	T7818	punct	),A
R5008	T7821	T7822	compound	Serum,acylcarnitine
R5009	T7822	T7819	compound	acylcarnitine,analysis
R5010	T7823	T7819	prep	of,analysis
R5011	T7824	T7825	nmod	MCAD,mice
R5012	T7825	T7823	pobj	mice,of
R5013	T7826	T7824	punct	+,MCAD
R5014	T7827	T7824	punct	/,MCAD
R5015	T7828	T7824	punct	+,MCAD
R5016	T7829	T7830	punct	(,4
R5017	T7830	T7824	parataxis	4,MCAD
R5018	T7831	T7830	nsubj	n,4
R5019	T7832	T7830	punct	=,4
R5020	T7833	T7830	punct	),4
R5021	T7834	T7824	cc	and,MCAD
R5022	T7835	T7824	conj	MCAD,MCAD
R5023	T7836	T7835	punct	−,MCAD
R5024	T7837	T7835	punct	/,MCAD
R5025	T7838	T7835	punct	−,MCAD
R5026	T7839	T7840	punct	(,4
R5027	T7840	T7825	parataxis	4,mice
R5028	T7841	T7840	nsubj	n,4
R5029	T7842	T7840	punct	=,4
R5030	T7843	T7840	punct	),4
R5031	T7845	T7846	expl	There,are
R5032	T7847	T7848	amod	significant,elevations
R5033	T7848	T7846	attr	elevations,are
R5034	T7849	T7846	prep	in,are
R5035	T7850	T7851	compound	acylcarnitine,species
R5036	T7851	T7849	pobj	species,in
R5037	T7852	T7853	mark	as,indicated
R5038	T7853	T7846	advcl	indicated,are
R5039	T7854	T7853	prep	in,indicated
R5040	T7855	T7856	nmod	MCAD,mice
R5041	T7856	T7854	pobj	mice,in
R5042	T7857	T7855	punct	−,MCAD
R5043	T7858	T7855	punct	/,MCAD
R5044	T7859	T7855	punct	−,MCAD
R5045	T7860	T7846	punct	.,are
R5046	T7862	T7863	nsubj	Values,are
R5047	T7864	T7862	acl	shown,Values
R5048	T7865	T7866	compound	mean,values
R5049	T7866	T7863	attr	values,are
R5050	T7867	T7866	punct	±,values
R5051	T7868	T7869	amod	standard,deviation
R5052	T7869	T7866	appos	deviation,values
R5053	T7870	T7869	punct	(,deviation
R5054	T7871	T7869	appos	SD,deviation
R5055	T7872	T7863	punct	),are
R5056	T7873	T7863	punct	.,are
R5057	T7875	T7876	nsubj	Asterisk,indicates
R5058	T7877	T7876	dobj	p,indicates
R5059	T7878	T7879	punct	<,0.002
R5060	T7879	T7877	amod	0.002,p
R5061	T7880	T7876	cc	and,indicates
R5062	T7881	T7882	nsubj	‡,indicates
R5063	T7882	T7876	conj	indicates,indicates
R5064	T7883	T7882	dobj	p,indicates
R5065	T7884	T7885	punct	<,0.01
R5066	T7885	T7883	amod	0.01,p
R5067	T7886	T7882	punct	.,indicates
R5068	T7888	T7889	punct	(,B
R5069	T7889	T7890	meta	B,are
R5070	T7891	T7889	punct	),B
R5071	T7892	T7890	expl	There,are
R5072	T7893	T7894	amod	significant,elevations
R5073	T7894	T7890	attr	elevations,are
R5074	T7895	T7894	prep	in,elevations
R5075	T7896	T7897	compound	bile,acylcarnitines
R5076	T7897	T7895	pobj	acylcarnitines,in
R5077	T7898	T7897	prep	of,acylcarnitines
R5078	T7899	T7900	det	the,mice
R5079	T7900	T7898	pobj	mice,of
R5080	T7901	T7900	amod	same,mice
R5081	T7902	T7900	acl	shown,mice
R5082	T7903	T7902	prep	in,shown
R5083	T7904	T7903	punct	(,in
R5084	T7905	T7903	pobj	A,in
R5085	T7906	T7902	punct	),shown
R5086	T7907	T7908	mark	as,indicated
R5087	T7908	T7902	advcl	indicated,shown
R5088	T7909	T7890	punct	.,are
R5089	T7911	T7912	nsubj	Values,are
R5090	T7913	T7911	acl	shown,Values
R5091	T7914	T7915	compound	mean,values
R5092	T7915	T7912	attr	values,are
R5093	T7916	T7915	punct	±,values
R5094	T7917	T7915	appos	SD,values
R5095	T7918	T7912	punct	.,are
R5096	T7920	T7921	nsubj	Asterisk,indicates
R5097	T7922	T7921	dobj	p,indicates
R5098	T7923	T7924	punct	<,0.001
R5099	T7924	T7922	amod	0.001,p
R5100	T7925	T7921	punct	.,indicates
R5101	T7927	T7928	punct	(,C
R5102	T7928	T7929	meta	C,profile
R5103	T7930	T7928	punct	),C
R5104	T7931	T7932	compound	Bile,acylcarnitine
R5105	T7932	T7929	compound	acylcarnitine,profile
R5106	T7933	T7929	prep	of,profile
R5107	T7934	T7935	det	an,mouse
R5108	T7935	T7933	pobj	mouse,of
R5109	T7936	T7935	nmod	MCAD,mouse
R5110	T7937	T7936	punct	−,MCAD
R5111	T7938	T7936	punct	/,MCAD
R5112	T7939	T7936	punct	−,MCAD
R5113	T7940	T7929	prep	compared,profile
R5114	T7941	T7940	prep	to,compared
R5115	T7942	T7943	det	a,patient
R5116	T7943	T7941	pobj	patient,to
R5117	T7944	T7943	amod	human,patient
R5118	T7945	T7943	prep	with,patient
R5119	T7946	T7947	compound	MCAD,deficiency
R5120	T7947	T7945	pobj	deficiency,with
R5121	T7948	T7929	punct	.,profile
R5122	T7950	T7951	amod	Internal,standards
R5123	T7951	T7952	nsubjpass	standards,indicated
R5124	T7953	T7952	auxpass	are,indicated
R5125	T7954	T7952	prep	by,indicated
R5126	T7955	T7956	det	an,asterisk
R5127	T7956	T7954	pobj	asterisk,by
R5128	T7957	T7952	punct	.,indicated
R5129	T8010	T8009	prep	of,Histopathology
R5130	T8011	T8012	nmod	MCAD,Mice
R5131	T8012	T8010	pobj	Mice,of
R5132	T8013	T8011	punct	+,MCAD
R5133	T8014	T8011	punct	/,MCAD
R5134	T8015	T8011	punct	+,MCAD
R5135	T8016	T8011	cc	and,MCAD
R5136	T8017	T8011	conj	MCAD,MCAD
R5137	T8018	T8017	punct	−,MCAD
R5138	T8019	T8017	punct	/,MCAD
R5139	T8020	T8017	punct	−,MCAD
R5140	T8022	T8023	punct	(,A
R5141	T8023	T8024	meta	A,had
R5142	T8025	T8023	punct	),A
R5143	T8026	T8027	nmod	MCAD,mice
R5144	T8027	T8024	nsubj	mice,had
R5145	T8028	T8026	punct	+,MCAD
R5146	T8029	T8026	punct	/,MCAD
R5147	T8030	T8026	punct	+,MCAD
R5148	T8031	T8032	det	no,evidence
R5149	T8032	T8024	dobj	evidence,had
R5150	T8033	T8032	prep	of,evidence
R5151	T8034	T8035	amod	hepatic,steatosis
R5152	T8035	T8033	pobj	steatosis,of
R5153	T8036	T8024	prep	following,had
R5154	T8037	T8038	det	a,fast
R5155	T8038	T8036	pobj	fast,following
R5156	T8039	T8040	nummod	24,h
R5157	T8040	T8038	compound	h,fast
R5158	T8041	T8040	punct	-,h
R5159	T8042	T8024	punct	.,had
R5160	T8044	T8045	compound	Liver,section
R5161	T8046	T8045	prep	with,section
R5162	T8047	T8048	nmod	Oil,O
R5163	T8048	T8051	compound	O,stain
R5164	T8049	T8048	punct	-,O
R5165	T8050	T8048	amod	Red,O
R5166	T8051	T8046	pobj	stain,with
R5167	T8052	T8045	punct	.,section
R5168	T8054	T8055	punct	(,B
R5169	T8055	T8056	meta	B,Hepatosteatosis
R5170	T8057	T8055	punct	),B
R5171	T8058	T8056	prep	in,Hepatosteatosis
R5172	T8059	T8060	compound	MCAD,−
R5173	T8060	T8063	compound	−,mouse
R5174	T8061	T8060	compound	−,−
R5175	T8062	T8060	punct	/,−
R5176	T8063	T8058	pobj	mouse,in
R5177	T8064	T8056	prep	following,Hepatosteatosis
R5178	T8065	T8066	det	a,fast
R5179	T8066	T8064	pobj	fast,following
R5180	T8067	T8068	nummod	24,h
R5181	T8068	T8066	compound	h,fast
R5182	T8069	T8068	punct	-,h
R5183	T8070	T8056	punct	.,Hepatosteatosis
R5184	T8072	T8073	nmod	Oil,O
R5185	T8073	T8076	npadvmod	O,stained
R5186	T8074	T8073	punct	-,O
R5187	T8075	T8073	amod	Red,O
R5188	T8076	T8077	amod	stained,sections
R5189	T8077	T8079	nsubj	sections,revealed
R5190	T8078	T8077	compound	liver,sections
R5191	T8080	T8081	amod	severe,steatosis
R5192	T8081	T8079	dobj	steatosis,revealed
R5193	T8082	T8080	cc	and,severe
R5194	T8083	T8080	conj	diffuse,severe
R5195	T8084	T8081	amod	microvesicular,steatosis
R5196	T8085	T8084	cc	and,microvesicular
R5197	T8086	T8084	conj	macrovesicular,microvesicular
R5198	T8087	T8081	amod	hepatic,steatosis
R5199	T8088	T8079	prep	in,revealed
R5200	T8089	T8090	nmod	MCAD,mice
R5201	T8090	T8088	pobj	mice,in
R5202	T8091	T8089	punct	−,MCAD
R5203	T8092	T8089	punct	/,MCAD
R5204	T8093	T8089	punct	−,MCAD
R5205	T8094	T8079	punct	.,revealed
R5206	T8096	T8097	punct	(,C
R5207	T8097	T8098	meta	C,cardiomyopathy
R5208	T8099	T8097	cc	and,C
R5209	T8100	T8097	conj	D,C
R5210	T8101	T8100	punct	),D
R5211	T8102	T8098	amod	Diffuse,cardiomyopathy
R5212	T8103	T8098	prep	with,cardiomyopathy
R5213	T8104	T8105	amod	chronic,degeneration
R5214	T8105	T8103	pobj	degeneration,with
R5215	T8106	T8105	amod	active,degeneration
R5216	T8107	T8105	amod	multifocal,degeneration
R5217	T8108	T8105	compound	myocyte,degeneration
R5218	T8109	T8105	cc	and,degeneration
R5219	T8110	T8105	conj	necrosis,degeneration
R5220	T8111	T8098	prep	in,cardiomyopathy
R5221	T8112	T8113	nmod	MCAD,mice
R5222	T8113	T8111	pobj	mice,in
R5223	T8114	T8112	punct	−,MCAD
R5224	T8115	T8112	punct	/,MCAD
R5225	T8116	T8112	punct	−,MCAD
R5226	T8117	T8098	punct	.,cardiomyopathy
R5227	T8162	T8161	prep	of,Characteristics
R5228	T8163	T8164	npadvmod	MCAD,Deficient
R5229	T8164	T8166	amod	Deficient,Mice
R5230	T8165	T8164	punct	-,Deficient
R5231	T8166	T8162	pobj	Mice,of
R1300	T2049	T2047	pobj	mice,between
R1308	T2057	T2054	punct	−,MCAD
R1309	T2058	T2059	punct	(,Figure
R1310	T2059	T2022	parataxis	Figure,revealed
R1311	T2060	T2059	nummod	3,Figure
R1312	T2061	T2059	punct	),Figure
R1313	T2062	T2022	punct	.,revealed
R1314	T2064	T2065	compound	Enzyme,activity
R1315	T2065	T2066	nsubjpass	activity,analyzed
R1316	T2067	T2066	auxpass	was,analyzed
R1317	T2068	T2066	prep	in,analyzed
R1318	T2069	T2070	compound	mouse,homogenates
R1319	T2070	T2068	pobj	homogenates,in
R1320	T2071	T2070	compound	liver,homogenates
R1321	T2072	T2066	advcl	using,analyzed
R1322	T2073	T2074	det	the,assay
R1323	T2074	T2072	dobj	assay,using
R1324	T2075	T2076	nmod	electron,flavoprotein
R1325	T2076	T2074	nmod	flavoprotein,assay
R1326	T2077	T2076	nmod	transport,flavoprotein
R1327	T2078	T2076	punct	(,flavoprotein
R1328	T2079	T2076	appos	ETF,flavoprotein
R1329	T2080	T2074	punct	),assay
R1330	T2081	T2074	compound	reduction,assay
R1331	T2082	T2072	prep	with,using
R1332	T2083	T2084	compound	octanoyl,CoA
R1333	T2084	T2082	pobj	CoA,with
R1334	T2085	T2084	punct	-,CoA
R1335	T2086	T2087	punct	(,C8
R1336	T2087	T2084	parataxis	C8,CoA
R1337	T2088	T2087	punct	:,C8
R1338	T2089	T2087	nummod	0,C8
R1339	T2090	T2087	punct	),C8
R2149	T3401	T3399	pobj	h,for
R2150	T3402	T3401	punct	-,h
R2151	T3403	T3379	punct	", ",were
R2152	T3404	T3379	expl	there,were
R2153	T3405	T3379	attr	minimal,were
R2154	T3406	T3405	prep	to,minimal
R2155	T3407	T3406	pobj	no,to
R2156	T3408	T3405	appos	abnormalities,minimal
R2157	T3409	T3379	prep	in,were
R2158	T3410	T3411	det	all,organs
R2159	T3411	T3409	pobj	organs,in
R2160	T3412	T3411	acl	evaluated,organs
R2161	T3413	T3379	punct	.,were
R2162	T3415	T3416	advmod	Only,mice
R2163	T3416	T3423	nsubj	mice,demonstrated
R2164	T3417	T3416	det	the,mice
R2165	T3418	T3416	amod	older,mice
R2166	T3419	T3416	nmod	MCAD,mice
R2167	T3420	T3419	punct	−,MCAD
R2168	T3421	T3419	punct	/,MCAD
R2169	T3422	T3419	punct	−,MCAD
R2170	T3424	T3423	punct	", ",demonstrated
R2171	T3425	T3423	advmod	therefore,demonstrated
R2172	T3426	T3423	punct	", ",demonstrated
R2173	T3427	T3428	amod	hepatic,steatosis
R2174	T3428	T3423	dobj	steatosis,demonstrated
R2175	T3429	T3423	punct	.,demonstrated
R2176	T3431	T3432	prep	In,found
R2177	T3433	T3431	pobj	addition,In
R2178	T3434	T3432	punct	", ",found
R2179	T3435	T3432	nsubj	we,found
R2180	T3436	T3437	amod	sporadic,lesions
R2181	T3437	T3432	dobj	lesions,found
R2182	T3438	T3437	amod	cardiac,lesions
R2183	T3439	T3432	prep	in,found
R2184	T3440	T3441	amod	multiple,mice
R2185	T3441	T3439	pobj	mice,in
R2186	T3442	T3441	nmod	MCAD,mice
R2191	T3448	T3449	prep	In,had
R2192	T3450	T3451	nummod	one,example
R2193	T3451	T3448	pobj	example,In
R2194	T3452	T3449	punct	", ",had
R2195	T3453	T3454	det	an,mouse
R2196	T3454	T3449	nsubj	mouse,had
R2197	T3455	T3454	nmod	MCAD,mouse
R2198	T3456	T3455	punct	−,MCAD
R2199	T3457	T3455	punct	/,MCAD
R2200	T3458	T3455	punct	−,MCAD
R2201	T3459	T3460	amod	diffuse,cardiomyopathy
R2202	T3460	T3449	dobj	cardiomyopathy,had
R2203	T3461	T3460	prep	with,cardiomyopathy
R2204	T3462	T3463	amod	chronic,degeneration
R2205	T3463	T3461	pobj	degeneration,with
R2206	T3464	T3463	amod	active,degeneration
R2207	T3465	T3463	amod	multifocal,degeneration
R2208	T3466	T3463	compound	myocyte,degeneration
R2209	T3467	T3463	cc	and,degeneration
R2210	T3468	T3463	conj	necrosis,degeneration
R673	T1067	T1065	pobj	region,of
R675	T1069	T1067	nmod	exon,region
R676	T1070	T1069	nummod	8,exon
R677	T1071	T1064	prep	in,results
R678	T1072	T1073	det	the,formation
R679	T1073	T1071	pobj	formation,in
R680	T1074	T1073	prep	of,formation
R681	T1075	T1076	amod	premature,codons
R682	T1076	T1074	pobj	codons,of
R683	T1077	T1076	compound	stop,codons
R684	T1078	T1073	acl	resulting,formation
R685	T1079	T1078	prep	in,resulting
R686	T1080	T1079	pobj	truncation,in
R687	T1081	T1080	prep	of,truncation
R688	T1082	T1083	det	the,monomer
R689	T1083	T1081	pobj	monomer,of
R739	T1138	T1139	compound	ES,cell
R740	T1139	T1140	compound	cell,clones
R741	T1140	T1141	nsubjpass	clones,screened
R742	T1142	T1141	auxpass	were,screened
R743	T1143	T1141	prep	by,screened
R744	T1144	T1143	pobj	PCR,by
R745	T1145	T1146	punct	(,shown
R746	T1146	T1141	parataxis	shown,screened
R747	T1147	T1146	nsubj	data,shown
R748	T1148	T1146	neg	not,shown
R749	T1149	T1146	punct	),shown
R750	T1150	T1141	cc	and,screened
R751	T1151	T1141	conj	confirmed,screened
R752	T1152	T1151	prep	by,confirmed
R753	T1153	T1154	compound	Southern,blot
R754	T1154	T1155	compound	blot,analysis
R755	T1155	T1152	pobj	analysis,by
R756	T1156	T1141	punct	.,screened
R757	T1158	T1159	compound	Southern,blot
R758	T1159	T1160	compound	blot,analysis
R759	T1160	T1161	nsubj	analysis,used
R760	T1162	T1163	det	an,probe
R761	T1163	T1161	dobj	probe,used
R762	T1164	T1163	nmod	exon,probe
R763	T1165	T1164	nummod	10,exon
R764	T1166	T1167	punct	(,A
R765	T1167	T1163	parataxis	A,probe
R766	T1168	T1167	compound	probe,A
R767	T1169	T1167	punct	),A
R768	T1170	T1163	punct	", ",probe
R769	T1171	T1172	neg	not,present
R770	T1172	T1163	relcl	present,probe
R771	T1173	T1172	prep	in,present
R772	T1174	T1175	det	the,vector
R773	T1175	T1173	pobj	vector,in
R774	T1176	T1175	compound	targeting,vector

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T1450	394-400	SO:0000440	denotes	vector
T1451	427-431	SO:0000147	denotes	exon
T1452	464-475	GO:0006412	denotes	Translation
T1453	494-498	SO:0000147	denotes	exon
T1454	536-557	SO:0001587	denotes	premature stop codons
T1455	627-647	SO:0001587	denotes	premature stop codon
T1456	661-672	GO:0006412	denotes	translation
T1457	719-723	SO:0000147	denotes	exon
T1458	780-786	SO:0000417	denotes	domain
T1459	787-796	SO:0001117	denotes	α-helixes
T1460	1627-1634	CL:0002322	denotes	ES cell
T1461	1752-1756	SO:0000147	denotes	exon
T1462	1796-1812	SO:0001644	denotes	targeting vector
T1463	1814-1824	GO:0097617	denotes	hybridized
T1464	1922-1928	SO:0000440	denotes	vector
T1465	1980-1987	CL:0002322	denotes	ES cell
T1466	2069-2073	NCBITaxon:10088	denotes	mice
T1467	2084-2088	NCBITaxon:10088	denotes	mice
T1468	2134-2138	NCBITaxon:10088	denotes	mice
T1469	2181-2185	NCBITaxon:10088	denotes	mice
T1470	2515-2519	NCBITaxon:10088	denotes	mice
T1471	2666-2671	GO:0016265	denotes	death
T1472	2724-2730	SO:0001023	denotes	allele
T1473	2873-2879	SO:0001023	denotes	allele
T1474	2911-2916	NCBITaxon:10088	denotes	mouse
T1475	2991-2998	SO:0001026	denotes	genomic
T1476	3023-3027	NCBITaxon:10088	denotes	mice
T1477	3133-3137	NCBITaxon:10088	denotes	mice
T1827	3198-3202	SO:0000147	denotes	exon
T1828	3222-3227	UBERON:0000948	denotes	heart
T1829	3259-3268	SO:0000028	denotes	base pair
T1830	3270-3272	SO:0000028	denotes	bp
T1831	3306-3310	NCBITaxon:10088	denotes	mice
T1832	3345-3349	NCBITaxon:10088	denotes	mice
T1833	3459-3463	SO:0000147	denotes	exon
T1834	3469-3473	SO:0000147	denotes	exon
T1835	3486-3488	SO:0000028	denotes	bp
T1836	3497-3504	SO:0000155	denotes	plasmid
T1837	3526-3531	SO:0000147	denotes	exons
T1838	3550-3557	SO:0000155	denotes	plasmid
T1839	3627-3634	GO:0008380	denotes	spliced
T1840	3692-3701	GO:0010467	denotes	expressed
T1841	3709-3716	UBERON:0000479	denotes	tissues
T1842	3739-3743	NCBITaxon:10088	denotes	mice
T1843	3765-3775	GO:0010467	denotes	expression
T1844	3789-3798	UBERON:0001348	denotes	brown fat
T1845	3800-3806	UBERON:0002113	denotes	kidney
T1846	3808-3813	UBERON:0000948	denotes	heart
T1847	3815-3823	UBERON:0004288	denotes	skeletal
T1848	3836-3841	UBERON:0002107	denotes	liver
T1849	3855-3865	GO:0010467	denotes	expression
T1850	3873-3878	UBERON:0000955	denotes	brain
T1851	3880-3889	UBERON:0001347	denotes	white fat
T1852	3895-3901	UBERON:0000473	denotes	testes
T1853	3970-3977	GO:0008380	denotes	spliced
T1854	3970-3977	_FRAGMENT	denotes	spliced
T1855	3984-3994	SO:1001187	denotes	transcript
T1856	4005-4016	SO:0000673	denotes	transcripts
T1857	4070-4074	NCBITaxon:10088	denotes	mice
T1858	4189-4216	GO:0000184	denotes	nonsense mediated RNA decay
T2183	4596-4601	UBERON:0002107	denotes	Liver
T2184	4641-4646	UBERON:0002107	denotes	liver
T2185	4678-4682	UBERON:0001977	denotes	sera
T2186	4748-4752	NCBITaxon:10088	denotes	mice
T2187	4773-4777	NCBITaxon:10088	denotes	mice
T2188	4818-4838	CHEBI:61905	denotes	short-chain acyl-CoA
T2189	4906-4916	GO:0010467	denotes	expression
T2190	4961-4965	NCBITaxon:10088	denotes	mice
T2191	5550-5555	NCBITaxon:10088	denotes	mouse
T2192	5556-5561	UBERON:0002107	denotes	liver
T2193	5584-5592	CHEBI:10545	denotes	electron
T2194	5584-5602	MOP:0000615	denotes	electron transport
T2195	5584-5615	GO:0045251	denotes	electron transport flavoprotein
T2196	5603-5615	CHEBI:5086	denotes	flavoprotein
T2197	5617-5620	GO:0045251	denotes	ETF
T2198	5622-5631	MOP:0000569	denotes	reduction
T2199	5643-5655	CHEBI:15533	denotes	octanoyl-CoA
T2200	5667-5680	CHEBI:15525	denotes	palmitoyl-CoA
T2201	5712-5716	NCBITaxon:10088	denotes	mice
T2202	5759-5772	MOP:0000590	denotes	dehydrogenate
T2203	5773-5785	CHEBI:15533	denotes	octanoyl-CoA
T2204	5828-5841	CHEBI:15525	denotes	palmitoyl-CoA
T2205	5862-5866	NCBITaxon:10088	denotes	mice
T2206	5896-5911	MOP:0000590	denotes	dehydrogenation
T2207	5915-5927	CHEBI:15533	denotes	octanoyl-CoA
T2208	5932-5945	CHEBI:15525	denotes	palmitoyl-CoA
T2209	6014-6018	NCBITaxon:10088	denotes	mice
T7397	938-943	NCBITaxon:10088	denotes	Mouse
T7398	950-954	SO:0000704	denotes	Gene
T7399	982-998	SO:0001644	denotes	targeting vector
T7400	1041-1045	SO:0000147	denotes	exon
T7401	1053-1061	SO:0000357	denotes	flanking
T7402	1193-1198	SO:0000147	denotes	exons
T7403	1229-1235	SO:0001023	denotes	allele
T7404	1282-1289	SO:0001026	denotes	genomic
T7405	1299-1307	CL:0002322	denotes	ES cells
T7406	1365-1380	SO:0000852	denotes	portion of exon
T7407	1411-1427	SO:0001644	denotes	targeting vector
T7408	1429-1439	GO:0097617	denotes	hybridizes
T7409	1562-1569	CL:0002322	denotes	ES cell
T7410	1612-1619	CL:0002322	denotes	ES cell
T7550	4292-4296	NCBITaxon:10088	denotes	Mice
T7551	4303-4310	SO:0000673	denotes	message
T7552	4303-4310	CHEBI:33695	denotes	message
T7553	4333-4338	UBERON:0000948	denotes	heart
T7554	4340-4345	UBERON:0002107	denotes	liver
T7555	4347-4356	UBERON:0001348	denotes	brown fat
T7556	4358-4363	UBERON:0000955	denotes	brain
T7557	4365-4371	UBERON:0002113	denotes	kidney
T7558	4389-4398	UBERON:0001347	denotes	white fat
T7559	4403-4409	UBERON:0000473	denotes	testes
T7560	4443-4447	NCBITaxon:10088	denotes	mice
T7561	4461-4471	GO:0010467	denotes	expression
T7562	4484-4493	UBERON:0001348	denotes	brown fat
T7563	4495-4501	UBERON:0002113	denotes	kidney
T7564	4503-4508	UBERON:0000948	denotes	heart
T7565	4514-4522	UBERON:0004288	denotes	skeletal
T7566	4539-4543	NCBITaxon:10088	denotes	mice
T7567	4562-4569	SO:0000673	denotes	message
T7568	4562-4569	CHEBI:33695	denotes	message
T7569	4577-4584	UBERON:0000479	denotes	tissues
T7750	5003-5008	UBERON:0002107	denotes	Liver
T7751	5046-5050	NCBITaxon:10088	denotes	Mice
T7752	5084-5092	GO:0042571	denotes	antibody
T7753	5106-5114	GO:0042571	denotes	antibody
T7754	5135-5139	NCBITaxon:10088	denotes	mice
T7755	5282-5287	UBERON:0002107	denotes	liver
T7756	5322-5330	GO:0042571	denotes	antibody
T7757	5398-5402	NCBITaxon:10088	denotes	mice
T7758	5462-5472	GO:0042571	denotes	antibodies
T8129	11098-11102	NCBITaxon:10088	denotes	mice
T8128	11053-11060	CL:0000187	denotes	myocyte
T8127	10983-10987	NCBITaxon:10088	denotes	mice
T8126	10954-10961	UBERON:0002107	denotes	hepatic
T8125	10944-10953	GO:0031982	denotes	vesicular
T8124	10925-10934	GO:0031982	denotes	vesicular
T8123	10877-10882	UBERON:0002107	denotes	liver
T8122	10830-10835	NCBITaxon:10088	denotes	mouse
T8121	10763-10768	UBERON:0002107	denotes	Liver
T8120	10722-10729	UBERON:0002107	denotes	hepatic
T8119	10698-10702	NCBITaxon:10088	denotes	mice
T8118	10681-10685	NCBITaxon:10088	denotes	Mice
T7970	9982-9987	NCBITaxon:9606	denotes	human
T7969	9962-9967	NCBITaxon:10088	denotes	mouse
T7968	9926-9939	CHEBI:17387	denotes	acylcarnitine
T7967	9921-9925	UBERON:0001970	denotes	Bile
T7966	9820-9824	NCBITaxon:10088	denotes	mice
T7965	9793-9807	CHEBI:17387	denotes	acylcarnitines
T7964	9788-9792	UBERON:0001970	denotes	bile
T7963	9631-9635	NCBITaxon:10088	denotes	mice
T7962	9585-9598	CHEBI:17387	denotes	acylcarnitine
T7961	9536-9540	NCBITaxon:10088	denotes	mice
T7960	9482-9495	CHEBI:17387	denotes	acylcarnitine
T7959	9476-9481	UBERON:0001977	denotes	Serum
T7958	9449-9462	CHEBI:17387	denotes	Acylcarnitine
T3606	11422-11428	GO:0005634	denotes	Nuclei
T3616	11874-11888	UBERON:0001013	denotes	adipose tissue
T3615	11781-11788	CHEBI:26130	denotes	pigment
T3614	11698-11704	UBERON:0000479	denotes	tissue
T3613	11643-11648	UBERON:0000948	denotes	heart
T3612	11618-11623	UBERON:0004663	denotes	aorta
T3611	11606-11613	_FRAGMENT	denotes	wall of
T3610	11565-11573	CL:0000187	denotes	myocytes
T3609	11500-11508	GO:0005730	denotes	nucleoli
T3608	11472-11481	GO:0031982	denotes	vesicular
T3607	11441-11449	CL:0000187	denotes	myocytes
T3605	11399-11411	CL:0000771	denotes	eosinophilic
T3604	11367-11377	GO:0030016	denotes	myofibrils
T3603	11340-11350	GO:0016528	denotes	sarcoplasm
T3602	11273-11281	CL:0000187	denotes	myocytes
T3601	11195-11202	CL:0000187	denotes	myocyte
T3600	11131-11136	NCBITaxon:10088	denotes	mouse
T3599	10627-10631	NCBITaxon:10088	denotes	mice
T3598	10591-10598	UBERON:0000948	denotes	cardiac
T3597	10541-10548	UBERON:0002107	denotes	hepatic
T3596	10511-10515	NCBITaxon:10088	denotes	mice
T3595	10470-10476	UBERON:0000062	denotes	organs
T3594	10402-10406	NCBITaxon:10088	denotes	mice
T3593	10302-10306	NCBITaxon:10088	denotes	mice
T3592	10281-10285	NCBITaxon:10088	denotes	mice
T3591	10241-10248	UBERON:0002107	denotes	hepatic
T3590	10231-10240	GO:0031982	denotes	vesicular
T3589	10212-10221	GO:0031982	denotes	vesicular
T3588	10163-10167	NCBITaxon:10088	denotes	mice
T3218	9424-9437	CHEBI:17387	denotes	acylcarnitine
T3217	9405-9410	NCBITaxon:10088	denotes	mouse
T3216	9382-9388	NCBITaxon:9606	denotes	humans
T3215	9365-9378	CHEBI:17387	denotes	acylcarnitine
T3214	9322-9326	NCBITaxon:10088	denotes	mice
T3213	9288-9302	CHEBI:17387	denotes	acylcarnitines
T3212	9223-9228	NCBITaxon:9606	denotes	Human
T3211	9180-9185	NCBITaxon:9606	denotes	human
T3210	9147-9151	NCBITaxon:10088	denotes	mice
T3209	9109-9122	CHEBI:17387	denotes	acylcarnitine
T3208	9077-9082	UBERON:0001977	denotes	serum
T3207	9049-9062	CHEBI:17387	denotes	acylcarnitine
T3206	9007-9020	CHEBI:17387	denotes	acylcarnitine
T3205	9002-9006	UBERON:0001970	denotes	Bile
T3204	8967-8980	CHEBI:17387	denotes	acylcarnitine
T3203	8934-8951	CHEBI:86063	denotes	decenoylcarnitine
T3202	8928-8933	UBERON:0001977	denotes	serum
T3201	8891-8895	NCBITaxon:10088	denotes	mice
T3200	8873-8877	NCBITaxon:10088	denotes	mice
T3199	8820-8829	CHEBI:17126	denotes	carnitine
T3198	8814-8819	UBERON:0001977	denotes	serum
T3197	8764-8768	NCBITaxon:10088	denotes	mice
T3196	8625-8636	CHEBI:15344	denotes	acetoacetic
T3195	8604-8620	CHEBI:20067	denotes	β-hydroxybutyric
T3194	8538-8549	CHEBI:30832	denotes	Adipic acid
T3193	8513-8526	CHEBI:64709	denotes	organic acids
T3192	8408-8423	CHEBI:64390	denotes	hexanoylglycine
T3191	8390-8403	CHEBI:41865	denotes	sebacic acids
T3190	8398-8403	CHEBI:9300	denotes	acids
T3189	8377-8384	_FRAGMENT	denotes	suberic
T3188	8398-8403	CHEBI:30832	denotes	acids
T3187	8369-8375	_FRAGMENT	denotes	adipic
T3186	8313-8317	NCBITaxon:10088	denotes	mice
T3185	8253-8258	NCBITaxon:9606	denotes	human
T3184	8206-8218	CHEBI:64709	denotes	organic acid
T2479	7068-7075	GO:0007618	denotes	matings
T2478	6994-7001	GO:0007618	denotes	matings
T2477	6963-6970	GO:0007618	denotes	matings
T2476	6602-6606	GO:0016265	denotes	loss
T2475	6560-6564	NCBITaxon:10088	denotes	mice
T2474	6505-6509	NCBITaxon:10088	denotes	mice
T2473	6479-6483	NCBITaxon:10088	denotes	mice
T2472	6449-6453	GO:0007567	denotes	born
T2471	6348-6354	GO:0016265	denotes	Deaths
T2820	8066-8072	UBERON:0001052	denotes	rectal
T2819	8008-8012	NCBITaxon:10088	denotes	mice
T2818	7955-7959	NCBITaxon:10088	denotes	mice
T2817	7893-7897	NCBITaxon:10088	denotes	mice
T2816	7789-7795	UBERON:0001052	denotes	Rectal
T2815	7775-7779	NCBITaxon:10088	denotes	mice
T2814	7715-7719	NCBITaxon:10088	denotes	mice
T2813	7685-7691	UBERON:0001052	denotes	rectal
T2812	7519-7523	NCBITaxon:10088	denotes	mice
T2811	7432-7436	NCBITaxon:10088	denotes	mice
T2810	7375-7379	NCBITaxon:10088	denotes	mice
T2809	7293-7303	CHEBI:35366	denotes	fatty acid
T2808	7282-7287	UBERON:0001977	denotes	serum
T2807	7261-7268	CHEBI:17234	denotes	glucose
T2806	7255-7260	UBERON:0001977	denotes	serum
T2805	7234-7238	NCBITaxon:10088	denotes	mice
T2804	7175-7179	NCBITaxon:10088	denotes	mice
T8169	6095-6099	NCBITaxon:10088	denotes	Mice
T3183	8188-8192	NCBITaxon:10088	denotes	mice
T3182	8144-8156	CHEBI:64709	denotes	organic acid
T3181	8138-8143	UBERON:0001088	denotes	Urine
T3180	8115-8128	CHEBI:17387	denotes	Acylcarnitine
T3179	8098-8110	CHEBI:64709	denotes	Organic Acid
T1443	9-13	SO:0000704	denotes	Gene
T1444	57-61	NCBITaxon:10088	denotes	Mice
T1445	77-83	SO:0000440	denotes	vector
T1446	213-221	CL:0002322	denotes	ES cells
T1447	294-299	SO:0000147	denotes	exons
T1448	332-340	SO:0000357	denotes	flanking
T1449	341-348	SO:0000155	denotes	plasmid
R1233	T1855	T1854	_lexicallyChainedTo	transcript,spliced
R2066	T3188	T3187	_lexicallyChainedTo	acids,adipic
R2067	T3190	T3189	_lexicallyChainedTo	acids,suberic
R2320	T3612	T3611	_lexicallyChainedTo	aorta,wall of

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T1482	67-76	SO_EXT:sequence_insertion_entity_or_process	denotes	insertion
T1484	85-89	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1485	119-129	GO_EXT:DNA_gap_repair	denotes	gap repair
T1486	142-143	CHEBI_SO_EXT:base	denotes	b
T1487	144-151	SO_EXT:sequence_deletion_process	denotes	deleted
T1488	175-188	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T1489	213-221	CL:0002322	denotes	ES cells
T1490	216-221	CL_GO_EXT:cell	denotes	cells
T1491	254-258	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1492	279-290	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1493	294-299	SO_EXT:0000147	denotes	exons
T1494	332-340	SO:0000357	denotes	flanking
T1495	341-348	SO_EXT:0000155	denotes	plasmid
T1496	353-356	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	Neo
T1497	357-366	SO_EXT:biological_sequence	denotes	sequences
T1498	384-393	SO_EXT:sequence_insertion_entity_or_process	denotes	insertion
T1499	394-400	SO_EXT:0000440	denotes	vector
T1500	417-426	SO_EXT:sequence_duplication_process	denotes	duplicate
T1501	427-431	SO_EXT:0000147	denotes	exon
T1502	452-456	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1503	464-475	GO:0006412	denotes	Translation
T1504	483-493	SO_EXT:sequence_duplication_process	denotes	duplicated
T1505	494-498	SO_EXT:0000147	denotes	exon
T1506	536-557	SO_EXT:0001587	denotes	premature stop codons
T1507	571-581	SO_EXT:sequence_truncation_entity_or_process	denotes	truncation
T1508	589-593	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1509	627-647	SO_EXT:0001587	denotes	premature stop codon
T1510	661-672	GO:0006412	denotes	translation
T1511	687-698	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T1512	708-718	SO_EXT:sequence_duplication_process	denotes	duplicated
T1513	719-723	SO_EXT:0000147	denotes	exon
T1514	741-745	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1515	769-779	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T1516	780-786	SO_EXT:0000417	denotes	domain
T1517	787-796	SO_EXT:0001117	denotes	α-helixes
T1518	878-882	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1519	887-895	GO_EXT:tetrameric_macromolecular_complex	denotes	tetramer
T1534	1983-1987	CL_GO_EXT:cell	denotes	cell
T1535	1988-1994	SO_EXT:sequence_cloned_entity	denotes	clones
T1536	2069-2073	NCBITaxon:10088	denotes	mice
T1537	2084-2088	NCBITaxon:10088	denotes	mice
T1538	2134-2138	NCBITaxon:10088	denotes	mice
T1539	2150-2154	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1540	2154-2155	SO_EXT:normal_or_wild_type_or_present	denotes	+
T1541	2156-2157	SO_EXT:sequence_nullness_or_absence	denotes	−
T1542	2173-2177	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1543	2177-2178	SO_EXT:sequence_nullness_or_absence	denotes	−
T1544	2179-2180	SO_EXT:sequence_nullness_or_absence	denotes	−
T1545	2181-2185	NCBITaxon:10088	denotes	mice
T1546	2399-2406	SO_EXT:sequence_altered_entity	denotes	mutants
T1547	2426-2434	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T1548	2449-2455	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T1549	2515-2519	NCBITaxon:10088	denotes	mice
T1550	2530-2538	GO_EXT:breeder	denotes	breeders
T1551	2542-2552	SO_EXT:wild_type_entity_or_quality	denotes	wild-types
T1552	2579-2584	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	Acadm
T1553	2585-2593	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T1554	2657-2665	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonatal
T1555	2666-2671	GO:0016265	denotes	death
T1556	2688-2697	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T1557	2724-2730	SO_EXT:0001023	denotes	allele
T1558	2798-2807	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T1559	2873-2879	SO_EXT:0001023	denotes	allele
T1560	2911-2916	NCBITaxon:10088	denotes	mouse
T1561	2921-2925	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1562	2925-2926	SO_EXT:sequence_nullness_or_absence	denotes	−
T1563	2927-2928	SO_EXT:sequence_nullness_or_absence	denotes	−
T1564	2932-2936	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1565	2936-2937	SO_EXT:normal_or_wild_type_or_present	denotes	+
T1566	2938-2939	SO_EXT:sequence_nullness_or_absence	denotes	−
T1567	2991-3002	SO_EXT:genomic_DNA	denotes	genomic DNA
T1568	2999-3002	CHEBI_SO_EXT:DNA	denotes	DNA
T1569	3015-3019	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1570	3019-3020	SO_EXT:sequence_nullness_or_absence	denotes	−
T1571	3021-3022	SO_EXT:sequence_nullness_or_absence	denotes	−
T1572	3023-3027	NCBITaxon:10088	denotes	mice
T1573	3113-3117	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1574	3117-3118	SO_EXT:sequence_nullness_or_absence	denotes	−
T1575	3119-3120	SO_EXT:sequence_nullness_or_absence	denotes	−
T1576	3125-3129	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1577	3129-3130	SO_EXT:normal_or_wild_type_or_present	denotes	+
T1578	3131-3132	SO_EXT:normal_or_wild_type_or_present	denotes	+
T1579	3133-3137	NCBITaxon:10088	denotes	mice
T1859	3159-3162	CHEBI_SO_EXT:RNA	denotes	RNA
T1860	3172-3174	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T1861	3198-3202	SO_EXT:0000147	denotes	exon
T1862	3222-3227	UBERON:0000948	denotes	heart
T1863	3228-3231	CHEBI_SO_EXT:RNA	denotes	RNA
T1864	3259-3263	CHEBI_SO_EXT:base	denotes	base
T1865	3259-3268	SO_EXT:0000028	denotes	base pair
T1866	3270-3272	SO_EXT:0000028	denotes	bp
T1867	3286-3290	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1868	3290-3291	SO_EXT:normal_or_wild_type_or_present	denotes	+
T1869	3292-3293	SO_EXT:normal_or_wild_type_or_present	denotes	+
T1870	3298-3302	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1871	3302-3303	SO_EXT:normal_or_wild_type_or_present	denotes	+
T1872	3304-3305	SO_EXT:sequence_nullness_or_absence	denotes	−
T1873	3306-3310	NCBITaxon:10088	denotes	mice
T1874	3323-3324	CHEBI_SO_EXT:base	denotes	b
T1875	3337-3341	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1876	3341-3342	SO_EXT:sequence_nullness_or_absence	denotes	−
T1877	3343-3344	SO_EXT:sequence_nullness_or_absence	denotes	−
T1878	3345-3349	NCBITaxon:10088	denotes	mice
T1879	3368-3376	SO_EXT:biological_sequence	denotes	Sequence
T1880	3398-3399	CHEBI_SO_EXT:base	denotes	b
T1881	3459-3463	SO_EXT:0000147	denotes	exon
T1882	3469-3473	SO_EXT:0000147	denotes	exon
T1883	3486-3488	SO_EXT:0000028	denotes	bp
T1884	3497-3504	SO_EXT:0000155	denotes	plasmid
T1885	3505-3513	SO_EXT:biological_sequence	denotes	sequence
T1886	3526-3531	SO_EXT:0000147	denotes	exons
T1887	3550-3557	SO_EXT:0000155	denotes	plasmid
T1888	3558-3567	SO_EXT:biological_sequence	denotes	sequences
T1889	3594-3602	SO_EXT:biological_sequence	denotes	sequence
T1890	3609-3616	SO_EXT:sequence_deletion_process	denotes	deleted
T1891	3627-3634	GO:0008380	denotes	spliced
T1892	3635-3639	CHEBI_SO_EXT:mRNA	denotes	mRNA
T1893	3673-3678	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	Acadm
T1894	3692-3701	GO:0010467	denotes	expressed
T1895	3709-3716	UBERON:0000479	denotes	tissues
T1896	3731-3735	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1897	3735-3736	SO_EXT:normal_or_wild_type_or_present	denotes	+
T1898	3737-3738	SO_EXT:normal_or_wild_type_or_present	denotes	+
T1899	3739-3743	NCBITaxon:10088	denotes	mice
T1900	3765-3775	GO:0010467	denotes	expression
T1901	3789-3798	UBERON:0001348	denotes	brown fat
T1902	3795-3798	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T1903	3800-3806	UBERON:0002113	denotes	kidney
T1904	3808-3813	UBERON:0000948	denotes	heart
T1905	3815-3830	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T1906	3836-3841	UBERON:0002107	denotes	liver
T1907	3855-3865	GO:0010467	denotes	expression
T1908	3873-3878	UBERON:0000955	denotes	brain
T1909	3880-3889	UBERON:0001347	denotes	white fat
T1910	3886-3889	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T1911	3895-3901	UBERON:0000473	denotes	testes
T1912	3938-3940	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T1913	3970-3977	GO:0008380	denotes	spliced
T1914	3970-3977	_FRAGMENT	denotes	spliced
T1915	3984-3994	SO_EXT:1001187	denotes	transcript
T1916	3978-3983	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	Acadm
T1917	3999-4004	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	Acadm
T1918	4005-4016	SO_EXT:0000673	denotes	transcripts
T1919	4062-4066	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1920	4066-4067	SO_EXT:sequence_nullness_or_absence	denotes	−
T1921	4068-4069	SO_EXT:sequence_nullness_or_absence	denotes	−
T1922	4070-4074	NCBITaxon:10088	denotes	mice
T1923	4116-4122	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T1924	4123-4126	CHEBI_SO_EXT:RNA	denotes	RNA
T1925	4189-4197	SO_EXT:nonsense_quality_or_entity	denotes	nonsense
T1926	4189-4216	GO:0000184	denotes	nonsense mediated RNA decay
T1927	4207-4210	CHEBI_SO_EXT:RNA	denotes	RNA
T2210	4596-4601	UBERON:0002107	denotes	Liver
T2211	4602-4608	CHEBI_GO_SO_EXT:enzyme	denotes	Enzyme
T2212	4641-4646	UBERON:0002107	denotes	liver
T2213	4669-4673	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2214	4678-4682	UBERON:0001977	denotes	sera
T2215	4712-4716	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2216	4740-4744	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2254	5773-5785	CHEBI:15533	denotes	octanoyl-CoA
T2255	5828-5841	CHEBI:15525	denotes	palmitoyl-CoA
T2256	5854-5858	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2257	5858-5859	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2258	5860-5861	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2259	5862-5866	NCBITaxon:10088	denotes	mice
T2260	5896-5911	MOP:0000590	denotes	dehydrogenation
T2261	5915-5927	CHEBI:15533	denotes	octanoyl-CoA
T2262	5932-5945	CHEBI:15525	denotes	palmitoyl-CoA
T2263	6006-6010	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2264	6010-6011	SO_EXT:sequence_nullness_or_absence	denotes	−
T2265	6012-6013	SO_EXT:sequence_nullness_or_absence	denotes	−
T2266	6014-6018	NCBITaxon:10088	denotes	mice
T2267	6034-6038	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2268	6038-6039	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2269	6040-6041	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7411	938-943	NCBITaxon:10088	denotes	Mouse
T7412	944-949	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	Acadm
T7413	950-954	SO_EXT:0000704	denotes	Gene
T7414	963-967	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7415	972-981	SO_EXT:sequence_insertion_entity_or_process	denotes	insertion
T7416	982-998	SO_EXT:0001644	denotes	targeting vector
T7417	1006-1013	SO_EXT:sequence_deletion_process	denotes	deleted
T7418	1019-1020	CHEBI_SO_EXT:base	denotes	b
T7419	1041-1045	SO_EXT:0000147	denotes	exon
T7420	1053-1061	SO:0000357	denotes	flanking
T7421	1062-1071	SO_EXT:biological_sequence	denotes	sequences
T7422	1073-1077	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7423	1092-1102	GO_EXT:DNA_gap_repair	denotes	gap repair
T7424	1119-1132	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T7425	1151-1156	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	Acadm
T7426	1178-1189	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T7427	1193-1198	SO_EXT:0000147	denotes	exons
T7428	1229-1235	SO_EXT:0001023	denotes	allele
T7429	1282-1293	SO_EXT:genomic_DNA	denotes	genomic DNA
T7430	1290-1293	CHEBI_SO_EXT:DNA	denotes	DNA
T7431	1299-1307	CL:0002322	denotes	ES cells
T7432	1302-1307	CL_GO_EXT:cell	denotes	cells
T7433	1325-1330	CHEBI_SO_EXT:molecular_probe	denotes	Probe
T7434	1336-1339	CHEBI_SO_EXT:DNA	denotes	DNA
T7435	1365-1380	SO_EXT:0000852	denotes	portion of exon
T7436	1411-1427	SO_EXT:0001644	denotes	targeting vector
T7437	1429-1439	GO:0097617	denotes	hybridizes
T7438	1462-1463	CHEBI_SO_EXT:base	denotes	b
T7439	1494-1507	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T7440	1520-1521	CHEBI_SO_EXT:base	denotes	b
T7441	1552-1561	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T7442	1562-1569	CL:0002322	denotes	ES cell
T7443	1565-1569	CL_GO_EXT:cell	denotes	cell
T7444	1612-1619	CL:0002322	denotes	ES cell
T7445	1615-1619	CL_GO_EXT:cell	denotes	cell
T7570	4256-4260	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7571	4260-4261	SO_EXT:sequence_nullness_or_absence	denotes	−
T7572	4262-4263	SO_EXT:sequence_nullness_or_absence	denotes	−
T7573	4276-4280	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7574	4280-4281	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7575	4282-4283	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7576	4292-4296	NCBITaxon:10088	denotes	Mice
T7577	4297-4302	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	Acadm
T7578	4303-4310	SO_EXT:0000673	denotes	message
T7579	4303-4310	CHEBI:33695	denotes	message
T7580	4333-4338	UBERON:0000948	denotes	heart
T7581	4340-4345	UBERON:0002107	denotes	liver
T7582	4347-4356	UBERON:0001348	denotes	brown fat
T7583	4353-4356	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T7584	4358-4363	UBERON:0000955	denotes	brain
T7585	4365-4371	UBERON:0002113	denotes	kidney
T7586	4377-4383	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T7587	4389-4398	UBERON:0001347	denotes	white fat
T7588	4395-4398	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T7589	4403-4409	UBERON:0000473	denotes	testes
T7590	4435-4439	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7591	4439-4440	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7592	4441-4442	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7593	4443-4447	NCBITaxon:10088	denotes	mice
T7594	4461-4471	GO:0010467	denotes	expression
T7595	4484-4493	UBERON:0001348	denotes	brown fat
T7596	4490-4493	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T7597	4495-4501	UBERON:0002113	denotes	kidney
T7598	4503-4508	UBERON:0000948	denotes	heart
T7599	4514-4529	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T7600	4531-4535	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7601	4535-4536	SO_EXT:sequence_nullness_or_absence	denotes	−
T7602	4537-4538	SO_EXT:sequence_nullness_or_absence	denotes	−
T7603	4539-4543	NCBITaxon:10088	denotes	mice
T7604	4562-4569	SO_EXT:0000673	denotes	message
T7605	4562-4569	CHEBI:33695	denotes	message
T7606	4577-4584	UBERON:0000479	denotes	tissues
T7759	5003-5008	UBERON:0002107	denotes	Liver
T7760	5026-5030	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7761	5030-5031	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7762	5032-5033	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7763	5038-5042	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7764	5042-5043	SO_EXT:sequence_nullness_or_absence	denotes	−
T7765	5044-5045	SO_EXT:sequence_nullness_or_absence	denotes	−
T7766	5046-5050	NCBITaxon:10088	denotes	Mice
T7767	5079-5083	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7768	5084-5092	GO:0042571	denotes	antibody
T7769	5101-5105	GO_PR_EXT:short_chain_acyl_CoA_dehydrogenase	denotes	SCAD
T7770	5106-5114	GO:0042571	denotes	antibody
T7771	5127-5131	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7772	5131-5132	SO_EXT:sequence_nullness_or_absence	denotes	−
T7773	5133-5134	SO_EXT:sequence_nullness_or_absence	denotes	−
T7774	5135-5139	NCBITaxon:10088	denotes	mice
T7775	5158-5162	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7776	5163-5170	CHEBI_PR_EXT:protein	denotes	protein
T7777	5172-5176	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7778	5177-5184	CHEBI_PR_EXT:protein	denotes	protein
T7779	5214-5218	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7780	5219-5226	CHEBI_PR_EXT:protein	denotes	protein
T7781	5282-5287	UBERON:0002107	denotes	liver
T7782	5317-5321	GO_PR_EXT:short_chain_acyl_CoA_dehydrogenase	denotes	SCAD
T7783	5322-5330	GO:0042571	denotes	antibody
T7784	5345-5349	GO_PR_EXT:short_chain_acyl_CoA_dehydrogenase	denotes	SCAD
T7785	5350-5357	CHEBI_PR_EXT:protein	denotes	protein
T7786	5378-5382	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7787	5382-5383	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7788	5384-5385	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7789	5390-5394	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7790	5394-5395	SO_EXT:sequence_nullness_or_absence	denotes	−
T7791	5396-5397	SO_EXT:sequence_nullness_or_absence	denotes	−
T7792	5398-5402	NCBITaxon:10088	denotes	mice
T7793	5407-5411	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7794	5429-5436	CHEBI_PR_EXT:protein	denotes	protein
T7795	5457-5461	GO_PR_EXT:short_chain_acyl_CoA_dehydrogenase	denotes	SCAD
T7796	5462-5472	GO:0042571	denotes	antibodies
T7797	5474-5478	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7798	5490-5499	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T8170	6080-6084	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T8171	6095-6099	NCBITaxon:10088	denotes	Mice
T8160	11098-11102	NCBITaxon:10088	denotes	mice
T8159	11096-11097	SO_EXT:sequence_nullness_or_absence	denotes	−
T8158	11094-11095	SO_EXT:sequence_nullness_or_absence	denotes	−
T8157	11090-11094	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T8156	11078-11086	GO_PATO_EXT:necrosis	denotes	necrosis
T8155	11053-11060	CL:0000187	denotes	myocyte
T8154	10983-10987	NCBITaxon:10088	denotes	mice
T8153	10981-10982	SO_EXT:sequence_nullness_or_absence	denotes	−
T8152	10979-10980	SO_EXT:sequence_nullness_or_absence	denotes	−
T8151	10975-10979	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T8150	10954-10961	UBERON:0002107	denotes	hepatic
T8149	10944-10953	GO:0031982	denotes	vesicular
T8148	10925-10934	GO:0031982	denotes	vesicular
T8147	10877-10882	UBERON:0002107	denotes	liver
T8146	10830-10835	NCBITaxon:10088	denotes	mouse
T8145	10828-10829	SO_EXT:sequence_nullness_or_absence	denotes	−
T8144	10826-10827	SO_EXT:sequence_nullness_or_absence	denotes	−
T8143	10822-10826	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T8142	10763-10768	UBERON:0002107	denotes	Liver
T8141	10722-10729	UBERON:0002107	denotes	hepatic
T8140	10698-10702	NCBITaxon:10088	denotes	mice
T8139	10696-10697	SO_EXT:normal_or_wild_type_or_present	denotes	+
T8138	10694-10695	SO_EXT:normal_or_wild_type_or_present	denotes	+
T8137	10690-10694	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T8136	10681-10685	NCBITaxon:10088	denotes	Mice
T8135	10679-10680	SO_EXT:sequence_nullness_or_absence	denotes	−
T8134	10677-10678	SO_EXT:sequence_nullness_or_absence	denotes	−
T8133	10673-10677	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T8132	10667-10668	SO_EXT:normal_or_wild_type_or_present	denotes	+
T8131	10665-10666	SO_EXT:normal_or_wild_type_or_present	denotes	+
T8130	10661-10665	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7996	10001-10005	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7995	9982-9987	NCBITaxon:9606	denotes	human
T7994	9962-9967	NCBITaxon:10088	denotes	mouse
T7993	9960-9961	SO_EXT:sequence_nullness_or_absence	denotes	−
T7992	9958-9959	SO_EXT:sequence_nullness_or_absence	denotes	−
T7991	9954-9958	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7990	9926-9939	CHEBI:17387	denotes	acylcarnitine
T7989	9921-9925	UBERON:0001970	denotes	Bile
T7988	9820-9824	NCBITaxon:10088	denotes	mice
T7987	9793-9807	CHEBI:17387	denotes	acylcarnitines
T7986	9788-9792	UBERON:0001970	denotes	bile
T7985	9631-9635	NCBITaxon:10088	denotes	mice
T7984	9629-9630	SO_EXT:sequence_nullness_or_absence	denotes	−
T7983	9627-9628	SO_EXT:sequence_nullness_or_absence	denotes	−
T7982	9623-9627	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7981	9585-9598	CHEBI:17387	denotes	acylcarnitine
T7980	9536-9540	NCBITaxon:10088	denotes	mice
T7979	9534-9535	SO_EXT:sequence_nullness_or_absence	denotes	−
T7978	9532-9533	SO_EXT:sequence_nullness_or_absence	denotes	−
T7977	9528-9532	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7976	9514-9515	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7975	9512-9513	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7974	9508-9512	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T7973	9482-9495	CHEBI:17387	denotes	acylcarnitine
T7972	9476-9481	UBERON:0001977	denotes	Serum
T7971	9449-9462	CHEBI:17387	denotes	Acylcarnitine
T3671	11874-11888	UBERON:0001013	denotes	adipose tissue
T3670	11781-11788	CHEBI_EXT:26130	denotes	pigment
T3669	11698-11704	UBERON:0000479	denotes	tissue
T3650	10627-10631	NCBITaxon:10088	denotes	mice
T3649	10625-10626	SO_EXT:sequence_nullness_or_absence	denotes	−
T3648	10623-10624	SO_EXT:sequence_nullness_or_absence	denotes	−
T3647	10619-10623	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3646	10591-10598	UBERON:0000948	denotes	cardiac
T3645	10541-10548	UBERON:0002107	denotes	hepatic
T3644	10511-10515	NCBITaxon:10088	denotes	mice
T3643	10509-10510	SO_EXT:sequence_nullness_or_absence	denotes	−
T3642	10507-10508	SO_EXT:sequence_nullness_or_absence	denotes	−
T3641	10503-10507	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3640	10470-10476	UBERON:0000062	denotes	organs
T3639	10402-10406	NCBITaxon:10088	denotes	mice
T3638	10400-10401	SO_EXT:sequence_nullness_or_absence	denotes	−
T3637	10398-10399	SO_EXT:sequence_nullness_or_absence	denotes	−
T3636	10394-10398	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3635	10388-10389	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3634	10386-10387	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3633	10382-10386	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3632	10302-10306	NCBITaxon:10088	denotes	mice
T3631	10300-10301	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3630	10298-10299	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3629	10294-10298	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3628	10281-10285	NCBITaxon:10088	denotes	mice
T3627	10279-10280	SO_EXT:sequence_nullness_or_absence	denotes	−
T3626	10277-10278	SO_EXT:sequence_nullness_or_absence	denotes	−
T3625	10273-10277	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3624	10241-10248	UBERON:0002107	denotes	hepatic
T3623	10231-10240	GO:0031982	denotes	vesicular
T3622	10212-10221	GO:0031982	denotes	vesicular
T3621	10163-10167	NCBITaxon:10088	denotes	mice
T3620	10153-10154	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3619	10151-10152	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3618	10147-10151	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3617	10136-10142	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3291	9424-9437	CHEBI:17387	denotes	acylcarnitine
T2864	8066-8072	UBERON:0001052	denotes	rectal
T2863	8008-8012	NCBITaxon:10088	denotes	mice
T3290	9405-9410	NCBITaxon:10088	denotes	mouse
T3262	8865-8869	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3261	8859-8860	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3260	8857-8858	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3259	8853-8857	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3258	8820-8829	CHEBI:17126	denotes	carnitine
T3257	8814-8819	UBERON:0001977	denotes	serum
T3256	8764-8768	NCBITaxon:10088	denotes	mice
T3255	8762-8763	SO_EXT:sequence_nullness_or_absence	denotes	−
T3254	8760-8761	SO_EXT:sequence_nullness_or_absence	denotes	−
T3253	8756-8760	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3252	8750-8751	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3251	8748-8749	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3250	8744-8748	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3249	8702-8711	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T3248	8697-8701	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3247	8625-8636	CHEBI:15344	denotes	acetoacetic
T3246	8604-8620	CHEBI:20067	denotes	β-hydroxybutyric
T3245	8569-8573	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3244	8538-8549	CHEBI:30832	denotes	Adipic acid
T3243	8513-8526	CHEBI:64709	denotes	organic acids
T3242	8445-8446	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3241	8443-8444	SO_EXT:normal_or_wild_type_or_present	denotes	+
T3240	8439-8443	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3239	8408-8423	CHEBI:64390	denotes	hexanoylglycine
T3238	8390-8403	CHEBI:41865	denotes	sebacic acids
T3237	8398-8403	CHEBI:9300	denotes	acids
T3236	8377-8384	_FRAGMENT	denotes	suberic
T3235	8398-8403	CHEBI:30832	denotes	acids
T3234	8369-8375	_FRAGMENT	denotes	adipic
T3233	8313-8317	NCBITaxon:10088	denotes	mice
T3232	8311-8312	SO_EXT:sequence_nullness_or_absence	denotes	−
T3231	8309-8310	SO_EXT:sequence_nullness_or_absence	denotes	−
T3230	8305-8309	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3229	8253-8258	NCBITaxon:9606	denotes	human
T3228	8238-8242	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3227	8206-8218	CHEBI:64709	denotes	organic acid
T3226	8188-8192	NCBITaxon:10088	denotes	mice
T3225	8186-8187	SO_EXT:sequence_nullness_or_absence	denotes	−
T3224	8184-8185	SO_EXT:sequence_nullness_or_absence	denotes	−
T3223	8180-8184	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3222	8144-8156	CHEBI:64709	denotes	organic acid
T3221	8138-8143	UBERON:0001088	denotes	Urine
T3220	8115-8128	CHEBI:17387	denotes	Acylcarnitine
T3219	8098-8110	CHEBI:64709	denotes	Organic Acid
T2507	6637-6638	SO_EXT:sequence_nullness_or_absence	denotes	−
T2506	6633-6637	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2505	6602-6606	GO:0016265	denotes	loss
T2504	6593-6601	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonatal
T2503	6560-6564	NCBITaxon:10088	denotes	mice
T2502	6558-6559	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2501	6556-6557	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2500	6552-6556	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2499	6505-6509	NCBITaxon:10088	denotes	mice
T2498	6503-6504	SO_EXT:sequence_nullness_or_absence	denotes	−
T2497	6501-6502	SO_EXT:sequence_nullness_or_absence	denotes	−
T2496	6497-6501	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2495	6479-6483	NCBITaxon:10088	denotes	mice
T2494	6477-6478	SO_EXT:sequence_nullness_or_absence	denotes	−
T2493	6475-6476	SO_EXT:sequence_nullness_or_absence	denotes	−
T2492	6471-6475	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2491	6465-6466	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2490	6463-6464	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2489	6459-6463	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2488	6449-6453	GO:0007567	denotes	born
T2487	6439-6443	NCBITaxon_UBERON_EXT:pup	denotes	pups
T2486	6407-6411	NCBITaxon_UBERON_EXT:pup	denotes	pups
T2485	6405-6406	SO_EXT:sequence_nullness_or_absence	denotes	−
T2484	6403-6404	SO_EXT:sequence_nullness_or_absence	denotes	−
T2483	6399-6403	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2482	6367-6375	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonatal
T2481	6348-6354	GO:0016265	denotes	Deaths
T3289	9382-9388	NCBITaxon:9606	denotes	humans
T3288	9365-9378	CHEBI:17387	denotes	acylcarnitine
T3287	9322-9326	NCBITaxon:10088	denotes	mice
T3286	9315-9321	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3285	9288-9302	CHEBI:17387	denotes	acylcarnitines
T3284	9223-9228	NCBITaxon:9606	denotes	Human
T3283	9186-9190	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3282	9180-9185	NCBITaxon:9606	denotes	human
T3281	9147-9151	NCBITaxon:10088	denotes	mice
T3280	9145-9146	SO_EXT:sequence_nullness_or_absence	denotes	−
T2862	8006-8007	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2861	8004-8005	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2860	8000-8004	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2859	7955-7959	NCBITaxon:10088	denotes	mice
T2858	7953-7954	SO_EXT:sequence_nullness_or_absence	denotes	−
T2857	7951-7952	SO_EXT:sequence_nullness_or_absence	denotes	−
T2856	7947-7951	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2855	7893-7897	NCBITaxon:10088	denotes	mice
T2854	7891-7892	SO_EXT:sequence_nullness_or_absence	denotes	−
T2853	7889-7890	SO_EXT:sequence_nullness_or_absence	denotes	−
T2852	7885-7889	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2851	7789-7795	UBERON:0001052	denotes	Rectal
T2850	7775-7779	NCBITaxon:10088	denotes	mice
T2849	7773-7774	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2848	7771-7772	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2847	7767-7771	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2846	7715-7719	NCBITaxon:10088	denotes	mice
T2845	7713-7714	SO_EXT:sequence_nullness_or_absence	denotes	−
T2844	7711-7712	SO_EXT:sequence_nullness_or_absence	denotes	−
T2843	7707-7711	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2842	7685-7691	UBERON:0001052	denotes	rectal
T2841	7628-7638	GO_EXT:fatality_or_lethality	denotes	fatalities
T2840	7519-7523	NCBITaxon:10088	denotes	mice
T2839	7517-7518	SO_EXT:sequence_nullness_or_absence	denotes	−
T2838	7515-7516	SO_EXT:sequence_nullness_or_absence	denotes	−
T2837	7511-7515	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2836	7432-7436	NCBITaxon:10088	denotes	mice
T2835	7375-7379	NCBITaxon:10088	denotes	mice
T2834	7373-7374	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2833	7371-7372	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2832	7367-7371	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2831	7293-7303	CHEBI:35366	denotes	fatty acid
T2830	7293-7298	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T2829	7282-7287	UBERON:0001977	denotes	serum
T2828	7261-7268	CHEBI:17234	denotes	glucose
T2827	7255-7260	UBERON:0001977	denotes	serum
T2826	7234-7238	NCBITaxon:10088	denotes	mice
T2825	7232-7233	SO_EXT:sequence_nullness_or_absence	denotes	−
T2824	7230-7231	SO_EXT:sequence_nullness_or_absence	denotes	−
T2823	7226-7230	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2822	7175-7179	NCBITaxon:10088	denotes	mice
T2821	7160-7164	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2542	7068-7075	GO:0007618	denotes	matings
T2541	6994-7001	GO:0007618	denotes	matings
T2540	6992-6993	SO_EXT:sequence_nullness_or_absence	denotes	−
T2539	6990-6991	SO_EXT:sequence_nullness_or_absence	denotes	−
T2538	6986-6990	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2537	6982-6983	SO_EXT:sequence_nullness_or_absence	denotes	−
T2536	6980-6981	SO_EXT:sequence_nullness_or_absence	denotes	−
T2535	6976-6980	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2534	6963-6970	GO:0007618	denotes	matings
T2533	6961-6962	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2532	6959-6960	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2531	6955-6959	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2530	6951-6952	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2529	6949-6950	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2528	6945-6949	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2527	6913-6921	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T2526	6903-6912	SO_EXT:sequence_insertion_entity_or_process	denotes	insertion
T2525	6873-6882	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T2524	6865-6869	NCBITaxon_UBERON_EXT:pup	denotes	pups
T2523	6850-6851	SO_EXT:sequence_nullness_or_absence	denotes	−
T2522	6848-6849	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2521	6844-6848	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2520	6827-6834	SO_EXT:sequence_altered_entity	denotes	mutants
T2519	6825-6826	SO_EXT:sequence_nullness_or_absence	denotes	−
T2518	6823-6824	SO_EXT:sequence_nullness_or_absence	denotes	−
T2517	6819-6823	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2516	6768-6769	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2515	6766-6767	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2514	6762-6766	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2513	6689-6693	NCBITaxon_UBERON_EXT:pup	denotes	pups
T2512	6687-6688	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2511	6685-6686	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2510	6681-6685	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2509	6641-6645	NCBITaxon_UBERON_EXT:pup	denotes	pups
T2508	6639-6640	SO_EXT:sequence_nullness_or_absence	denotes	−
T2480	6339-6347	PATO_UBERON_EXT:neonate_or_newborn	denotes	Neonatal
T2217	4744-4745	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2218	4746-4747	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2219	4748-4752	NCBITaxon:10088	denotes	mice
T2220	4765-4769	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2221	4769-4770	SO_EXT:sequence_nullness_or_absence	denotes	−
T2222	4771-4772	SO_EXT:sequence_nullness_or_absence	denotes	−
T2223	4773-4777	NCBITaxon:10088	denotes	mice
T2224	4818-4838	CHEBI:61905	denotes	short-chain acyl-CoA
T2225	4818-4852	GO_PR_EXT:short_chain_acyl_CoA_dehydrogenase	denotes	short-chain acyl-CoA dehydrogenase
T2226	4854-4858	GO_PR_EXT:short_chain_acyl_CoA_dehydrogenase	denotes	SCAD
T2227	4906-4916	GO:0010467	denotes	expression
T2228	4920-4924	GO_PR_EXT:short_chain_acyl_CoA_dehydrogenase	denotes	SCAD
T2229	4925-4932	CHEBI_PR_EXT:protein	denotes	protein
T2230	4941-4945	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2231	4945-4946	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2232	4947-4948	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2233	4953-4957	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2234	4957-4958	SO_EXT:sequence_nullness_or_absence	denotes	−
T2235	4959-4960	SO_EXT:sequence_nullness_or_absence	denotes	−
T2236	4961-4965	NCBITaxon:10088	denotes	mice
T2237	5518-5524	CHEBI_GO_SO_EXT:enzyme	denotes	Enzyme
T2238	5550-5555	NCBITaxon:10088	denotes	mouse
T2239	5556-5561	UBERON:0002107	denotes	liver
T2240	5584-5592	CHEBI:10545	denotes	electron
T2241	5584-5602	MOP:0000615	denotes	electron transport
T2242	5584-5615	GO:0045251	denotes	electron transport flavoprotein
T2243	5593-5602	GO_EXT:biological_routing_or_transport	denotes	transport
T2244	5603-5615	CHEBI:5086	denotes	flavoprotein
T2245	5617-5620	GO:0045251	denotes	ETF
T2246	5622-5631	MOP:0000569	denotes	reduction
T2247	5643-5655	CHEBI:15533	denotes	octanoyl-CoA
T2248	5667-5680	CHEBI:15525	denotes	palmitoyl-CoA
T2249	5704-5708	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T2250	5708-5709	SO_EXT:sequence_nullness_or_absence	denotes	−
T2251	5710-5711	SO_EXT:sequence_nullness_or_absence	denotes	−
T2252	5712-5716	NCBITaxon:10088	denotes	mice
T2253	5759-5772	MOP:0000590	denotes	dehydrogenate
T3268	8889-8890	SO_EXT:sequence_nullness_or_absence	denotes	−
T3267	8887-8888	SO_EXT:sequence_nullness_or_absence	denotes	−
T3266	8883-8887	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3265	8873-8877	NCBITaxon:10088	denotes	mice
T3264	8871-8872	SO_EXT:sequence_nullness_or_absence	denotes	−
T3263	8869-8870	SO_EXT:sequence_nullness_or_absence	denotes	−
T3279	9143-9144	SO_EXT:sequence_nullness_or_absence	denotes	−
T3278	9139-9143	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T3277	9109-9122	CHEBI:17387	denotes	acylcarnitine
T3276	9077-9082	UBERON:0001977	denotes	serum
T3275	9049-9062	CHEBI:17387	denotes	acylcarnitine
T3274	9007-9020	CHEBI:17387	denotes	acylcarnitine
T3273	9002-9006	UBERON:0001970	denotes	Bile
T3272	8967-8980	CHEBI:17387	denotes	acylcarnitine
T3271	8934-8951	CHEBI:86063	denotes	decenoylcarnitine
T3270	8928-8933	UBERON:0001977	denotes	serum
T3269	8891-8895	NCBITaxon:10088	denotes	mice
T3668	11643-11648	UBERON:0000948	denotes	heart
T3667	11618-11623	UBERON:0004663	denotes	aorta
T3666	11606-11613	_FRAGMENT	denotes	wall of
T3665	11565-11573	CL:0000187	denotes	myocytes
T3664	11500-11508	GO:0005730	denotes	nucleoli
T3663	11472-11481	GO:0031982	denotes	vesicular
T3662	11441-11449	CL:0000187	denotes	myocytes
T3661	11422-11428	GO:0005634	denotes	Nuclei
T3660	11399-11411	CL:0000771	denotes	eosinophilic
T3659	11367-11377	GO:0030016	denotes	myofibrils
T3658	11340-11350	GO:0016528	denotes	sarcoplasm
T3657	11273-11281	CL:0000187	denotes	myocytes
T3656	11220-11228	GO_PATO_EXT:necrosis	denotes	necrosis
T3655	11195-11202	CL:0000187	denotes	myocyte
T3654	11131-11136	NCBITaxon:10088	denotes	mouse
T3653	11129-11130	SO_EXT:sequence_nullness_or_absence	denotes	−
T3652	11127-11128	SO_EXT:sequence_nullness_or_absence	denotes	−
T3651	11123-11127	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1478	9-13	SO_EXT:0000704	denotes	Gene
T1479	42-46	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1480	57-61	NCBITaxon:10088	denotes	Mice
T1481	62-66	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T1483	77-83	SO_EXT:0000440	denotes	vector
T1520	1627-1634	CL:0002322	denotes	ES cell
T1521	1630-1634	CL_GO_EXT:cell	denotes	cell
T1522	1635-1641	SO_EXT:sequence_cloned_entity	denotes	clones
T1523	1752-1756	SO_EXT:0000147	denotes	exon
T1524	1760-1765	CHEBI_SO_EXT:molecular_probe	denotes	probe
T1525	1767-1772	CHEBI_SO_EXT:molecular_probe	denotes	probe
T1526	1796-1812	SO_EXT:0001644	denotes	targeting vector
T1527	1814-1824	GO:0097617	denotes	hybridized
T1528	1836-1837	CHEBI_SO_EXT:base	denotes	b
T1529	1867-1868	CHEBI_SO_EXT:base	denotes	b
T1530	1905-1914	SO_EXT:sequence_insertion_entity_or_process	denotes	insertion
T1531	1922-1928	SO_EXT:0000440	denotes	vector
T1532	1936-1941	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	Acadm
T1533	1980-1987	CL:0002322	denotes	ES cell
R1234	T1915	T1914	_lexicallyChainedTo	transcript,spliced
R2068	T3235	T3234	_lexicallyChainedTo	acids,adipic
R2069	T3237	T3236	_lexicallyChainedTo	acids,suberic
R2321	T3667	T3666	_lexicallyChainedTo	aorta,wall of

PMC:1189074 / 4340-16229 JSONTXT

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PMC:1189074 / 4340-16229 JSON TXT